diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..04183139c1dd7bf3d9dc848b024a55f975895c9c --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Ubiquitin-conjugating enzyme, active site [IPR023313]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ca8387b8f49e54ef8b67b3bbd5f75aeee29293dc --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fb9329798cfcded5140cf5470e640bef03a7216f80919386bb885280da8a8689 +size 142629 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..2852b34ca3038973d791085de61aee3c70478d5e --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8611e97563581282e428a5cdb2cd755a5ae30c39983744e2f835790c37db367a +size 72979 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c7e3785c40c13de3efdcbfeebeb7ce727aebcb2c --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 57, + "title": "Average number of proteins per term", + "value": 2.5789473684210527 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..23f3e4c7bcc573972376832a1d41ea475596de98 --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8d3b72c340c3b3a592e0a1e8c3381651e386aa48 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.9572564612326092 1.4702587155488924 0.1414916977903373 0.9998327229103778 0.2949503267686009 3 Q9HB40,P10619 2 +Histidine acid phosphatase active site [IPR033379] 0.8665120900960632 1.186751413881484 0.235325688497556 0.999999771881482 0.456373439942523 2 Q9NPH0 1 +Protein-tyrosine phosphatase, active site [IPR016130] 0.5783099811711483 1.059245842407062 0.2894878323694287 0.99999999653601 0.5322840788728206 7 P10586,Q9Y217 2 +ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440] 0.70486916197417 0.589495224046485 0.5555291150153883 1.0 0.7536185801370007 2 P53597 1 +Ubiquitin-conjugating enzyme, active site [IPR023313] 0.4278606965174062 0.4232451732208883 0.6721163914189239 1.0 0.7662126862175732 6 Q16763,P49427,P61086,P61081,P61088 5 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7fdc946005b25a466f919ceedbaf8dd4b1ec6ce2 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CASP7", "CDC34", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLK2", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP11", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LONP2", "LYN", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "MTMR6", "NCEH1", "NEK9", "NME1", "NME2", "NME6", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKG1", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRC", "SRPK1", "SUCLG1", "TALDO1", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "WNK2"], "leading_proteins": ["ACP6", "CDC34", "CTSA", "MTMR6", "PTPRF", "SCPEP1", "SUCLG1", "UBE2K", "UBE2M", "UBE2N", "UBE2S"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e8085172482fa2f0c787badbafde4720b1ecbf3d --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Beta tubulin, autoregulation binding site [IPR013838]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..eff192a9b6cc5b1eb7e6f771991e00af08228dec --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ba3d05614a40ecea7bba70e4420b4bcdffe81955117bba6ed446b8de0280ddf5 +size 171356 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e8085172482fa2f0c787badbafde4720b1ecbf3d --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Beta tubulin, autoregulation binding site [IPR013838]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..b8fd2a7330fd0bdaddb8ef74595d38e14dddae74 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d1734365195030809f159d5f0249a3aa25a991aa000deb41081d40035490559a +size 146393 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..193f82e86b38bc3576ce49a1d9c22fc1da17e673 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e962d043066fe36885e25db5a4d2606e846a84f26edc0ef3ab7fd2cbdeb6cd8b +size 68849 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f9fd333c36307d1799f84cf41118317ceafe674d --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Beta tubulin, autoregulation binding site [IPR013838] 6 7 2.730276917747799 0.0063281145339988 3.5533980582524274 5.54126213592233 0.5823511994709325 0.3808337519133083 1.5578062452886454 0.9632803779920796 1.1906256051626651 0.3058955364405814 3.40260461815712e-08 5.354324033305364e-08 2.1615500006651521e-13 1.5998774522859254e-10 2.1037423825620157e-08 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..923ad53e207df65a23d8c260798ea6c8a491bdd4 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 30, + "title": "Average number of proteins per term", + "value": 4.733333333333333 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b0c6c71f03067ea5a21302460718a0e9c05f4575 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3331e4e55ee7ce3f2893bf2b8d1801f455034264 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Beta tubulin, autoregulation binding site [IPR013838] 0.9721300597212992 2.730276917747799 0.0063281145339988 0.1734101512491168 0.088606426565484 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +EF-Hand 1, calcium-binding site [IPR018247] 0.289541153783392 0.1414671420082124 0.8875009158361984 1.0 1.0 34 Q9BPX6,Q96AY3,Q02818,P80303 4 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ab2e5c18375fa1ab758b203c0ffcafad751a0747 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHEK1", "CHUK", "CLK2", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EHD1", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCSH", "PRKG1", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRC", "SRI", "SRPK1", "STK26", "STK4", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["FKBP10", "MICU1", "NUCB1", "NUCB2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c93cc64b00f56d60bbfc4ef509c4066c2cda4450 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tubulin, conserved site [IPR017975]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..031b95f403d7fe8b97213aba09b3bd717c5bbcd8 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:727f9cf58d0004491ce37399dc642da10817d870d1cff7cd17008f36ed88079a +size 181463 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..dc08cac12917073e564fbed0258f561d220c8116 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tubulin, conserved site [IPR017975]", "1": "Ubiquitin specific protease, conserved site [IPR018200]", "2": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "3": "Tr-type G domain, conserved site [IPR031157]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1a7da4032919fb5b3e0ca63bffc45e434ca6b228 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:eaca74675340e4b06cbeb5bb9482cbc2f2cc7ed639efa2c44bf105ac8718a539 +size 140861 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..b9ed6d4a15d1d66e1a2680541c3f91d21ee9fa87 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6db987f619a7bb871004e37f42fcc4589efa98cf866e3c61d1c8516a472aad1c +size 140189 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..cf1f96e14cfcb729d1d52d33ca891f7c5d9e9fce --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:54d160f4b2b231c2cdfb29d6dbd150b7cb6ce04f09ee2d752da00a7b852db702 +size 154633 diff --git a/interpro_conserved_site/basic/plot_3.png b/interpro_conserved_site/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..52ce9d8104281ecbc8edeb0a56dbfbf2cbbc57a0 --- /dev/null +++ b/interpro_conserved_site/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1e7e3ef14e3318f25bdd000b68c60309431b90b28905a4608abaffd5025b5a53 +size 150230 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..432e8f21a59fa36bb2b543097f6e506fdcbfe624 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:aab977e9807945e6956d53e1c21e0e6226fe667cf91c92ec2920d41f192cca6e +size 93611 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e725d2766756dd60d0364d6883f5891fed7a0f09 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tubulin, conserved site [IPR017975] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +Proteasome beta-type subunit, conserved site [IPR016050] 4 7 2.117372091843419 0.0342282808333131 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.0 0.0921025797166938 6.393058955734768e-05 5.5966724052351854e-05 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..51ff64ca2cd91bb775b7139148bc340b87e49150 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 270, + "title": "Average number of proteins per term", + "value": 2.6555555555555554 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8634265706f51d825bd7aa2cd190a7b917fc9da5 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6d0776e9e10a7ec3fb77e0edcf0ef961d1fc968c --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,37 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tubulin, conserved site [IPR017975] 0.972130059721299 2.730276917747799 0.0063281145339988 0.8198598138680202 0.1177460454772605 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Proteasome beta-type subunit, conserved site [IPR016050] 0.8204426325088174 2.117372091843419 0.0342282808333131 0.9999175651958632 0.17772376586528 7 P20618,P28070,P49720,P49721 4 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892] 0.6353649651013786 1.7670075573676882 0.0772269626584178 0.999999999623624 0.2673241015099081 12 Q6UX04,Q9H2H8 2 +Haem oxygenase conserved site [IPR018207] 0.9963564094070884 1.7009111707539326 0.0889596686751463 0.9999999999881108 0.2797738075000446 2 P30519 1 +Ubiquitin specific protease, conserved site [IPR018200] 0.6043696244196511 1.5619219267965423 0.1183063823070285 0.9999999999999982 0.3275990699359794 11 Q86UV5,Q96K76,P51784,O94966,Q9Y4E8 5 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.8893673401788673 1.2766848589950823 0.2017135290397012 1.0 0.4488118474646156 2 P04066 1 +Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.6369016625745769 1.188332727875096 0.2347023485532442 1.0 0.4881268567125728 5 Q13315,O00443 2 +D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753] 0.6937354988399022 1.1303572986290813 0.2583256995547058 1.0 0.5166513991094117 4 P56545,Q13363,O43175 3 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.8402632326013523 1.0499294164348274 0.2937505657564587 1.0 0.5432373476318073 3 Q9BXS5 1 +Mrp, conserved site [IPR000808] 0.7989400463729739 0.9259802618540276 0.3544562379933971 1.0 0.6100698488053375 2 Q8TB37 1 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.7948972829688546 0.8911684266015916 0.3728388200400827 1.0 0.6248469703841244 3 P09429,P26583 2 +Sterol reductase, conserved site [IPR018083] 0.7880092745942409 0.8848904261737482 0.3762157320848436 1.0 0.6248469703841244 2 Q14739 1 +F-actin capping protein, alpha subunit, conserved site [IPR017865] 0.7853593905266676 0.8749898831754436 0.381579410394762 1.0 0.6248469703841244 2 P47755 1 +Dynein light chain, type 1/2, conserved site [IPR019763] 0.757204372308716 0.771471057957619 0.4404277708767039 1.0 0.6718389725237857 2 P63167 1 +Profilin conserved site [IPR027310] 0.7366677707850333 0.698221034814921 0.4850389736363212 1.0 0.7125268675710342 2 P07737 1 +DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.7273931765485318 0.6658741551209958 0.5054915412877263 1.0 0.7337780438047641 2 P28340 1 +ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847] 0.70486916197417 0.589495224046485 0.5555291150153883 1.0 0.7652696992558919 2 P53597 1 +D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752] 0.7018880423981517 0.5796378390717081 0.562158870246825 1.0 0.7664058843066708 2 Q13363 1 +Macrophage migration inhibitory factor, conserved site [IPR019829] 0.7005631003643656 0.575276865750702 0.565104064848112 1.0 0.7664058843066708 2 P14174 1 +Cullin, conserved site [IPR016157] 0.4841424576741173 0.561837070345592 0.574227032515368 1.0 0.7675311820749968 5 Q13616,Q13617 2 +4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900] 0.6740642596886461 0.4908366987524925 0.6235419515181102 1.0 0.7802125625651452 2 P21912 1 +14-3-3 protein, conserved site [IPR023409] 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 0.7859967698425546 5 P62258,P31946,P63104,Q04917 4 +Oxysterol-binding protein, conserved site [IPR018494] 0.5105420624235573 0.4534930880290335 0.6501937193845961 1.0 0.7987664721403637 4 P22059 1 +Phosphofructokinase, conserved site [IPR015912] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.850540972604233 3 P17858 1 +Guanylate kinase, conserved site [IPR020590] 0.3921234365630869 0.3013665075627859 0.7631350309033911 1.0 0.8548514257820318 6 Q14168 1 +DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.3392328103348196 0.2762001880572153 0.7823943128015536 1.0 0.8647704309638918 13 Q92620,Q8IX18,Q9H2U1,Q86WJ1,Q14562 5 +Ribosomal protein L7Ae conserved site [IPR004037] 0.5604504802914994 0.2061061627179438 0.8367079849686241 1.0 0.9109320804093892 2 P55769 1 +Tr-type G domain, conserved site [IPR031157] 0.3446102819237104 0.1675678316744465 0.8669232799138085 1.0 0.9261110543187836 6 Q05639,P13639,Q96RP9,Q8N442,P49411 5 +Chromo domain, conserved site [IPR023779] 0.3246021220159139 0.1071859005812753 0.9146415006930956 1.0 0.9633735476554568 5 P45973,Q13185,O14646,P83916 4 +Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.4614110632659981 0.0809287808068452 0.9354985912561082 1.0 0.9752301916569468 2 P11216 1 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.304112054279709 0.0762365870004693 0.939230875157212 1.0 0.9753551395863356 7 Q02252 1 +Ubiquitin-activating enzyme E1, conserved site [IPR018074] 0.3935077840344648 0.0495886535799265 0.9604501886403124 1.0 0.9817187441952888 2 Q9UBT2 1 +Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.3895329579331004 0.0486342125972713 0.9612108045052106 1.0 0.9817187441952888 2 P15880 1 +S100/Calbindin-D9k, conserved site [IPR001751] 0.3888704869162101 0.0484821489062244 0.9613319908197676 1.0 0.9817187441952888 2 P31949 1 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.3749585955614539 0.045713294447204 0.9635387674509316 1.0 0.9817187441952888 2 P13473 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.3595096090125849 0.0375038787499685 0.9700832475289528 1.0 0.9846709655369073 3 Q08426,Q16836 2 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2b90e7ee37ef6342c5e78c22acf158465a911ef4 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycerate/sugar phosphate transporter, conserved site [IPR021159]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP3M1", "AP3S1", "APEX1", "APP", "ARIH2", "ATAD1", "ATAD2", "ATAD2B", "ATM", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF7", "DCP2", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E2", "ENO1", "EP300", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCDH7", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRKG1", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS24", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RSF1", "RTCA", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A3", "SLC27A4", "SLC37A4", "SLC4A2", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STX12", "STX18", "STX3", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ALDH6A1", "AP1M1", "ATM", "CAPZA2", "CBX1", "CBX3", "CBX5", "CHD1", "CHD1L", "CTBP1", "CTBP2", "CUL1", "CUL2", "CWC27", "DHX36", "DHX38", "DHX40", "DHX8", "DYNLL1", "EEF1A2", "EEF2", "EHHADH", "FUCA1", "GFM1", "GUF1", "HADH", "HMGB1", "HMGB2", "HMOX2", "LAMP2", "LBR", "MIF", "MPP2", "NUBPL", "OSBP", "PFKL", "PFN1", "PHGDH", "PIK3C2A", "POLD1", "PPIL3", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PYGB", "RPS2", "S100A11", "SDHB", "SNU13", "SUCLG1", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "UBA2", "USP11", "USP15", "USP19", "USP47", "USP48", "YWHAB", "YWHAE", "YWHAH", "YWHAZ"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new 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b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7e70ee5ec108a66d23e3456131243cc5657356ab7027b7441062b95ce70d3162 +size 292579 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d7cf6ce62837fe70ff8506865ee87b9f39cbde7f --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tubulin/FtsZ, GTPase domain [IPR003008] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 6.27148000065891e-07 9.8377873283803e-07 1.0966940165838888e-10 7.31307507873348e-08 8.061508148359063e-06 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..af3492fbd0a6acc402c8cbb01bd84189c81347bb --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 2546, + "title": "Average number of proteins per term", + "value": 2.1661429693637078 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3b0130fde4475f10096873dc7eb9477d65fc2160 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1245a2258d1b2f305993679774a23c60af79f02d --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,188 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tubulin/FtsZ, GTPase domain [IPR003008] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9999999043502752 0.1671913637701073 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9999999043502752 0.1671913637701073 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.7723912696713852 1.892332818537432 0.0584466509133423 1.0 0.2489382106668773 6 O15173,O43169 2 +Phox homology [IPR001683] 0.648405527230551 1.739644527305115 0.0819214554754546 1.0 0.2974392440321658 10 Q9Y5X1 1 +THIF-type NAD/FAD binding fold [IPR000594] 0.7275526756901377 1.700058098886973 0.089119997763325 1.0 0.3094618681995511 6 Q9UBE0 1 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.725769803238549 1.692347613683864 0.0905797144251179 1.0 0.3124877410926154 6 Q9NZ08,Q9UIQ6,P09960 3 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.725769803238549 1.692347613683864 0.0905797144251179 1.0 0.3124877410926154 6 Q9NZ08,Q9UIQ6,P09960 3 +ERAP1-like C-terminal domain [IPR024571] 0.8046787980931807 1.570062029025894 0.1164006812335762 1.0 0.3527123825176207 4 Q9UIQ6 1 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9698475811795904 1.5157372499191637 0.1295858046217408 1.0 0.3752300609587531 3 Q15629,Q96G23 2 +Ubiquitin specific protease domain [IPR028889] 0.5809052696807513 1.483933981813931 0.1378264356300342 1.0 0.3847504891874658 12 Q86UV5,Q96K76,P51784,O94966,Q9Y4E8 5 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.5809052696807513 1.483933981813931 0.1378264356300342 1.0 0.3847504891874658 12 Q86UV5,Q96K76,P51784,O94966,Q9Y4E8 5 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130] 0.5531514309059261 1.426440946247985 0.1537411015284056 1.0 0.4075374077171889 14 Q6UX04,Q9H2H8,Q13356 3 +Isochorismatase-like [IPR000868] 0.9108976482278908 1.3618294656280514 0.1732517102032318 1.0 0.4350087319304025 2 Q96AB3 1 +Potentiating neddylation domain [IPR005176] 0.8999668764491562 1.3185620529008295 0.1873155670096644 1.0 0.4549375294061174 2 Q96GG9 1 +Mu homology domain [IPR028565] 0.7408554385804069 1.3172128978640294 0.187767271769931 1.0 0.4552909275488041 4 Q9BXS5 1 +Major facilitator superfamily domain [IPR020846] 0.9078860172299544 1.291978316582096 0.1963646538628007 1.0 0.4703145895904899 3 Q14728,O43826 2 +Morc, S5 domain 2-like [IPR041006] 0.891685988737994 1.2858378110900095 0.1984996711725091 1.0 0.4723179091637459 2 Q9Y6X9 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.7310795732339761 1.2783920439798189 0.2011112278942441 1.0 0.476306219738368 4 Q9UKA9 1 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.8893673401788673 1.2766848589950823 0.2017135290397012 1.0 0.4772887034712632 2 P04066 1 +Peptidase M28 [IPR007484] 0.7208989660754576 1.23797785573417 0.2157242718612684 1.0 0.4912647550615289 4 Q969V3,P02786 2 +Zinc finger, CW-type [IPR011124] 0.8919814446653467 1.234705414931728 0.2169401598840821 1.0 0.4931514705936367 3 Q9Y6X9,Q8NB78 2 +Far upstream element-binding protein, C-terminal [IPR015096] 0.873799271281883 1.2153625255049345 0.2242278542261968 1.0 0.4970472739184011 2 Q92945 1 +MPN domain [IPR037518] 0.5595932688965403 1.1914686479126906 0.2334696575363875 1.0 0.5089158802120227 9 O95630,P51665,Q7L5N1,O00487,Q92905,O15372,Q15018 7 +Marvel domain [IPR008253] 0.8572374958595583 1.1504396254195848 0.2499628474069495 1.0 0.5294456322477425 2 O43760 1 +Bicarbonate transporter, C-terminal [IPR011531] 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.5336517125824778 2 Q9Y6M7 1 +Band 3 cytoplasmic domain [IPR013769] 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.5336517125824778 2 Q9Y6M7 1 +D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139] 0.6937354988399022 1.1303572986290813 0.2583256995547058 1.0 0.5351482758879423 4 P56545,Q13363,O43175 3 +D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140] 0.6937354988399022 1.1303572986290813 0.2583256995547058 1.0 0.5351482758879423 4 P56545,Q13363,O43175 3 +Pre-PUA domain [IPR041366] 0.8393507784034476 1.0807949157816572 0.2797883505595075 1.0 0.5571665936250104 2 P41214 1 +NADP-dependent oxidoreductase domain [IPR023210] 0.6800897154644401 1.076504339871702 0.2817017610207872 1.0 0.5590122241301047 4 P48507 1 +Pleckstrin homology domain [IPR001849] 0.4649998457014141 1.0698954742749538 0.2846663604487653 1.0 0.5622657515147841 18 P22059,Q96TA1,Q96AC1,Q9Y5P4,Q96P47 5 +Ubiquitin-like domain, USP-type [IPR028135] 0.8350447167936439 1.0641161449725245 0.2872760878698881 1.0 0.563743967036162 2 Q9Y4E8 1 +Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120] 0.8310698906922842 1.0487540891863134 0.2942913127436362 1.0 0.5706517001106609 2 O00154 1 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.8353214049039126 1.0324469566622918 0.3018627842214285 1.0 0.5804702784197561 3 Q86UV5,Q9Y4E8 2 +Rpn11/EIF3F, C-terminal [IPR024969] 0.6652303612860418 1.0181130427299283 0.3086242377086234 1.0 0.5885822540870077 4 O00487,Q7L5N1,P51665 3 +Bromo adjacent homology (BAH) domain [IPR001025] 0.5906979132491521 0.9923347469540552 0.3210342586468933 1.0 0.6058956430800522 5 P26358,Q13330,Q9BTC8 3 +NECAP, PHear domain [IPR012466] 0.814508115269962 0.9851317034676944 0.3245593824134976 1.0 0.6080413448305849 2 Q8NC96 1 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.5367089724596636 0.9730628993415782 0.3305220417887589 1.0 0.6175206052153018 8 O95630,P51665,Q7L5N1,O00487,Q92905,O15372 6 +Glutamine amidotransferase [IPR017926] 0.6515446294661171 0.9646375271849256 0.3347263961724176 1.0 0.6225079654163442 4 Q9NRF8 1 +Immunoglobulin subtype 2 [IPR003598] 0.5116278597127388 0.9585021627715422 0.3378096014216898 1.0 0.6268682545332523 9 P10586,Q9BY67 2 +CTP synthase GATase domain [IPR033828] 0.8015899304405496 0.935998825249121 0.3492737925583768 1.0 0.6366978067289157 2 Q9NRF8 1 +CTP synthase, N-terminal [IPR017456] 0.8015899304405496 0.935998825249121 0.3492737925583768 1.0 0.6366978067289157 2 Q9NRF8 1 +Reticulon [IPR003388] 0.8077856674584645 0.935834243880318 0.3493585373135488 1.0 0.6366978067289157 3 Q9NQC3 1 +Peptidase M20, dimerisation domain [IPR011650] 0.7966213978138501 0.9172318496872116 0.3590211604308266 1.0 0.6425244473164492 2 Q96KP4 1 +Protein-tyrosine phosphatase, catalytic [IPR003595] 0.5713321701339811 0.9110866786080364 0.3622497048508792 1.0 0.6445931961970376 5 P10586 1 +Zinc finger, B-box, chordata [IPR020457] 0.794965220271616 0.9109934084873338 0.3622988467234724 1.0 0.6445931961970376 2 P19474 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.6338926182135486 0.896220366081247 0.3701350805227705 1.0 0.650803808709236 4 P23634,P16615 2 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.6338926182135486 0.896220366081247 0.3701350805227705 1.0 0.650803808709236 4 P23634,P16615 2 +BTB/POZ domain [IPR000210] 0.7952161320287912 0.8922685103386546 0.3722490284106821 1.0 0.6528590504452626 3 Q08380 1 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.7943746429330882 0.8893657937633932 0.3738065222626348 1.0 0.6549975262771288 3 Q14919 1 +Guanine nucleotide exchange factor, N-terminal [IPR032691] 0.7870155680689003 0.8811748388403322 0.3782231955532547 1.0 0.660917128262585 2 Q7Z3U7 1 +FAD linked oxidase, N-terminal [IPR006094] 0.7850281550182248 0.873754056842416 0.3822522053310391 1.0 0.6657115452848678 2 Q15392 1 +FAD-binding domain, PCMH-type [IPR016166] 0.7850281550182248 0.873754056842416 0.3822522053310391 1.0 0.6657115452848678 2 Q15392 1 +PIK-related kinase [IPR014009] 0.6263093988617539 0.8670615455151746 0.3859082889087633 1.0 0.6657115452848678 4 Q13315 1 +PIK-related kinase, FAT [IPR003151] 0.6263093988617539 0.8670615455151746 0.3859082889087633 1.0 0.6657115452848678 4 Q13315 1 +FATC domain [IPR003152] 0.6263093988617539 0.8670615455151746 0.3859082889087633 1.0 0.6657115452848678 4 Q13315 1 +Cold-shock (CSD) domain [IPR019844] 0.6253990435015642 0.8635716554626135 0.3878232404978781 1.0 0.6657115452848678 4 P16989,Q9Y2V2 2 +Cold shock domain [IPR011129] 0.5563707440519898 0.8489299125545986 0.3959202930565189 1.0 0.6711138922249646 5 P16989,Q9Y2V2 2 +Cold-shock protein, DNA-binding [IPR002059] 0.5563707440519898 0.8489299125545986 0.3959202930565189 1.0 0.6711138922249646 5 P16989,Q9Y2V2 2 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.7806494367130623 0.8422899869797725 0.3996256544094498 1.0 0.674135983009601 3 P51784,Q9Y4E8 2 +SPRY-associated [IPR006574] 0.6197341872895494 0.8419094120499324 0.3998386615686113 1.0 0.674135983009601 4 P19474 1 +Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 0.5266576324975156 0.8315465370469503 0.4056649499833384 1.0 0.6817313284868514 7 Q13315,O00443 2 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.7721099701888081 0.8258747071169702 0.4088751697070618 1.0 0.6844156358147137 2 P52701 1 +Immunoglobulin subtype [IPR003599] 0.4598715021593534 0.7887063677560906 0.4302836453013965 1.0 0.6956618319184297 10 P10586,Q9BY67 2 +L27 domain [IPR004172] 0.5189792978068051 0.7870345290190804 0.4312616534689697 1.0 0.6958617175222663 6 Q8NI35,Q14168 2 +Dbl homology (DH) domain [IPR000219] 0.7578668433256087 0.7738682224073508 0.4390087233027411 1.0 0.7003234395543727 2 Q9H8V3 1 +Zinc finger, CHHC-type [IPR012996] 0.7584650542313279 0.7674095211791669 0.4428380693946441 1.0 0.7040943591739782 3 P31943 1 +Immunoglobulin-like domain [IPR007110] 0.4503917582232413 0.7663762773944622 0.4434524439134233 1.0 0.7043230955730354 11 P10586,Q9BY67 2 +Class II aldolase/adducin N-terminal [IPR001303] 0.7545544882411439 0.7619027391594492 0.4461180550565102 1.0 0.7059145855648695 2 P35611 1 +Dynamin, N-terminal [IPR045063] 0.5105907392306426 0.7514589913289987 0.4523764718486491 1.0 0.7098956736128084 6 O95140,Q8IWA4,Q9H4M9 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.5105907392306426 0.7514589913289987 0.4523764718486491 1.0 0.7098956736128084 6 O95140,Q8IWA4,Q9H4M9 3 +Tim44-like domain [IPR007379] 0.7512421331566792 0.7499889841716204 0.4532613393376858 1.0 0.7100789676024315 2 Q9BRJ2 1 +Legume-like lectin [IPR005052] 0.7472673070553223 0.7357628490773417 0.4618750338955708 1.0 0.7182513832520495 2 P49257 1 +Zinc finger, RanBP2-type [IPR001876] 0.5022527604889276 0.7264688149266251 0.4675514183895739 1.0 0.7231992170229983 7 Q01844 1 +NOPS [IPR012975] 0.7382372432074418 0.7006764736330385 0.4835049413819019 1.0 0.7323043312066164 3 Q15233,Q8WXF1 2 +PIN domain [IPR002716] 0.7310367671414431 0.678523529591846 0.4974398101534152 1.0 0.7381553312869381 2 Q9ULX3 1 +DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133] 0.7276341948310205 0.6663779743528068 0.5051695372093903 1.0 0.7415329510109097 3 Q07864,P28340 2 +DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134] 0.7276341948310205 0.6663779743528068 0.5051695372093903 1.0 0.7415329510109097 3 Q07864,P28340 2 +Helicase/UvrB, N-terminal [IPR006935] 0.7239024921588296 0.6544289125911383 0.512835512167733 1.0 0.7449416011875035 3 Q9UPY3 1 +DNA mismatch repair protein MutS, core [IPR007696] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.7449928392582443 3 P52701 1 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.7449928392582443 3 P52701 1 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.7449928392582443 3 P52701 1 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.7449928392582443 3 P52701 1 +Glutamine amidotransferase type 2 domain [IPR017932] 0.7157057654075522 0.6284191129262178 0.529729419631165 1.0 0.7530827020394287 3 Q06203,Q06210 2 +Fibronectin type II domain [IPR000562] 0.7161311692613508 0.6272791400245415 0.5304762746803622 1.0 0.7530827020394287 2 Q9UBV2 1 +Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038] 0.5608220086178235 0.6239021409520012 0.5326918541928074 1.0 0.7530827020394287 4 P55769,Q9NX24,P62888 3 +CS domain [IPR007052] 0.4400338852799452 0.6208394602205863 0.5347052571210056 1.0 0.7536324124910591 9 Q8WVJ2,Q9UHD1,Q15185,Q9HB71,O94966 5 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.7088439880755281 0.6027339213780821 0.5466857115968258 1.0 0.7622463426755304 2 Q9NVE7 1 +CoA-binding [IPR003781] 0.70486916197417 0.589495224046485 0.5555291150153883 1.0 0.7691012108913423 2 P53597 1 +PUA domain [IPR002478] 0.5493527739963815 0.5834804315372268 0.5595699264649459 1.0 0.7728439854392263 4 P41214 1 +BRO1 domain [IPR004328] 0.6965882742630076 0.5622695107285408 0.5739324081623507 1.0 0.7785493615868982 2 Q8WUM4 1 +Cullin protein, neddylation domain [IPR019559] 0.4841424576741173 0.561837070345592 0.574227032515368 1.0 0.7785493615868982 5 Q13616,Q13617 2 +Cullin, N-terminal [IPR001373] 0.4604634256478264 0.5465011638267864 0.5847214879336222 1.0 0.7827028960457425 6 Q13616,Q93034,Q13617 3 +Cullin homology domain [IPR016158] 0.4604634256478264 0.5465011638267864 0.5847214879336222 1.0 0.7827028960457425 6 Q13616,Q93034,Q13617 3 +PDZ domain [IPR001478] 0.3696322815552751 0.5269486071236212 0.5982292780019574 1.0 0.7896434398606794 19 O00560,Q9Y4G8 2 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.6769724442500832 0.5104835152455626 0.609712760643192 1.0 0.7960964280001323 3 P31689 1 +Fzo/mitofusin HR2 domain [IPR006884] 0.6763829082477717 0.4980022353832314 0.6184824666122921 1.0 0.7998723312049206 2 Q8IWA4 1 +4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896] 0.6712114918714747 0.493731298212867 0.621495958283129 1.0 0.7998723312049206 3 P21912 1 +Ubiquitin-conjugating enzyme E2 [IPR000608] 0.4281447062728243 0.4929554726531612 0.6220440499131974 1.0 0.7998723312049206 8 Q9NR09,Q16763,P49427,P61086,P61081,P61088,Q9C0C9 7 +CARG-binding factor, N-terminal [IPR012956] 0.6727393176548602 0.4867624029551629 0.626426716809307 1.0 0.7998723312049206 2 Q99729 1 +Ribosomal protein L18e/L15P [IPR021131] 0.666132590149018 0.4791499731827136 0.631831940650164 1.0 0.8004018914370753 3 P46776 1 +14-3-3 domain [IPR023410] 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 0.801981644319574 5 P62258,P31946,P63104,Q04917 4 +Nucleotidyl transferase domain [IPR005835] 0.6640915667648528 0.4733410454273843 0.6359698830935725 1.0 0.8020855430524173 3 Q9Y5P6 1 +L27 domain, C-terminal [IPR014775] 0.4569038414663634 0.4623091600854661 0.6438596316844487 1.0 0.8075205035805942 5 Q14168 1 +Ubiquitin-like domain [IPR000626] 0.3754975654454221 0.4599540048100729 0.6455492353041408 1.0 0.8092409419420692 14 P46379,Q86UV5,Q8NCF5 3 +K Homology domain, type 1 [IPR004088] 0.3483831760218937 0.4567643312495028 0.6478404459140439 1.0 0.8105168428978652 21 Q96PU8,Q15366,Q06787,Q07666,Q9NQT5,Q92945,Q96AE4 7 +tRNA-binding domain [IPR002547] 0.6608148393507864 0.4507780311622947 0.6521495364050862 1.0 0.8108721180637205 2 Q12904 1 +Gelsolin-like domain [IPR007123] 0.4302463500010182 0.4319155491657216 0.6658027931889259 1.0 0.8173258975212175 6 Q15436 1 +Butyrophylin-like, SPRY domain [IPR003879] 0.4479872572012717 0.4311867864414783 0.6663325608960431 1.0 0.8175761762883205 5 P19474 1 +Poly(ADP-ribose) polymerase, catalytic domain [IPR012317] 0.6477799867461974 0.4280100012275449 0.6686438389945053 1.0 0.8176050658213219 3 Q9UGN5,Q7Z2W4 2 +Tyrosine-specific protein phosphatases domain [IPR000387] 0.4113517413323152 0.4258062461020268 0.6702490351901644 1.0 0.8183666613822026 8 P10586 1 +Metastasis-associated protein MTA1, R1 domain [IPR035170] 0.6315440689198109 0.3849410301843258 0.7002811061408951 1.0 0.8381509450704393 3 Q9BTC8,Q13330 2 +ERM family, FERM domain C-lobe [IPR041789] 0.6298873426109969 0.380668018434702 0.703449602854402 1.0 0.8392952697011385 3 P35241,P26038 2 +Ubiquitin system component CUE [IPR003892] 0.6293743191354688 0.3793495387850076 0.7044283172025203 1.0 0.8392952697011385 3 Q9H4L7 1 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.6292246520874796 0.3789653124724069 0.7047136226066901 1.0 0.8392952697011385 3 Q01968,Q6L8Q7 2 +Domain of unknown function DUF1747 [IPR013719] 0.6339847631666207 0.3746504492637723 0.7079204481319348 1.0 0.8397804835711654 2 Q08945 1 +TRASH domain [IPR011017] 0.42782623469113 0.3639087306601269 0.7159261649020738 1.0 0.8434743247758816 5 Q5SVZ6 1 +Zinc finger, UBR-type [IPR003126] 0.6139827700463842 0.3408546842341527 0.73321298076428 1.0 0.853181101017302 3 Q5T4S7,Q8IWV8 2 +Methyltransferase type 11 [IPR013216] 0.607687210072892 0.3257198633136924 0.7446363143591113 1.0 0.856646337978978 3 Q6UX53,Q8N6R0 2 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.6151043391851706 0.3254742589812061 0.7448221613598482 1.0 0.856646337978978 2 O43390 1 +Phosphofructokinase domain [IPR000023] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.8601576619937219 3 P17858 1 +GINS subunit, domain A [IPR021151] 0.6061609804571152 0.3035425206854407 0.7614764481724359 1.0 0.8665934194419476 2 Q9BRX5 1 +KOW [IPR005824] 0.3927537053710157 0.303373246641807 0.7616054316434231 1.0 0.8665934194419476 6 P62701 1 +EF-hand domain [IPR002048] 0.3139391212380915 0.2947885711143061 0.768155397616354 1.0 0.8688403518670068 40 Q9BPX6,Q66K14,Q96AY3,Q02818,P80303,P60660 6 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.8688403518670068 3 Q9UL46,P61289 2 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.8688403518670068 3 Q9UL46,P61289 2 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.5918575922027021 0.2893066197504811 0.7723467469923386 1.0 0.8720154402849197 3 Q9NUQ9 1 +Proteasome alpha-subunit, N-terminal domain [IPR000426] 0.3867301755768978 0.284521332677951 0.7760108881596492 1.0 0.8749883619373193 7 P60900 1 +Immunoglobulin V-set domain [IPR013106] 0.4503645339268245 0.2793248332623064 0.779995550232548 1.0 0.8771504730088635 4 Q9BY67 1 +Ricin B, lectin domain [IPR000772] 0.4477958236658833 0.2727954467981927 0.7850104597972378 1.0 0.8808447027958429 4 Q10471,Q86SF2,Q10472 3 +Dual specificity phosphatase, catalytic domain [IPR000340] 0.394577163866985 0.2638049375976081 0.7919302296651909 1.0 0.884875113305032 5 Q8WUK0 1 +Dual specificity protein phosphatase domain [IPR020422] 0.394577163866985 0.2638049375976081 0.7919302296651909 1.0 0.884875113305032 5 Q8WUK0 1 +Glycosyl transferase, family 1 [IPR001296] 0.4441744415814729 0.2637298198494227 0.7919881158580195 1.0 0.884875113305032 4 P37287,Q2TAA5 2 +SH3 domain [IPR001452] 0.3073079110621162 0.2474399235711085 0.804567780023834 1.0 0.8929509886402273 35 Q9Y5X1 1 +Translation initiation factor, beta propellor-like domain [IPR013979] 0.575687313680038 0.2357852447507314 0.8135993183714496 1.0 0.8990554967767842 2 Q9BY44 1 +Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099] 0.573699900629359 0.2317526501890879 0.8167301354784426 1.0 0.9020301960994548 2 O60256 1 +Dilute domain [IPR002710] 0.5710500165617871 0.2264509037189957 0.8208507405494574 1.0 0.9054965274865332 2 P55196 1 +Domain of unknown function DUF4749 [IPR031847] 0.5703875455448941 0.2251388963915357 0.8218712226735521 1.0 0.9057769119298624 2 O00151 1 +Phosphoribosyltransferase domain [IPR000836] 0.375663129973476 0.2137844056248546 0.8307151863340685 1.0 0.912298879100718 5 O60256,Q06203,P00492,P07741 4 +Amidohydrolase-related [IPR006680] 0.4219423268147076 0.2117758536224031 0.8322819072721237 1.0 0.9133576447908736 4 Q9BPU6,Q14195,Q16555 3 +Citron homology (CNH) domain [IPR001180] 0.5624378933421783 0.2098153777236103 0.8338117705152164 1.0 0.9138548289848216 2 Q8WUH2 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.3270444002530258 0.1784129653502132 0.8583986677806523 1.0 0.9351660283138814 9 Q96AY3,Q9Y680 2 +CD80-like, immunoglobulin C2-set [IPR013162] 0.5312513440885066 0.1733151754996637 0.8624036958760055 1.0 0.9379238828279838 3 Q9BY67 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.3547745358090211 0.1650065223011296 0.8689388483755855 1.0 0.9422139301380924 5 P35580,Q9Y4I1,P35579,Q9UM54 4 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059] 0.5322954620735476 0.1588022079834807 0.8738247091689828 1.0 0.9463027263054998 2 P47897 1 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.5289831069890826 0.1538780299043946 0.8777059073617921 1.0 0.9488913970883748 2 P51114 1 +Zinc finger, GATA-type [IPR000679] 0.3470599181959217 0.1487838531382537 0.881724192144923 1.0 0.95242672600805 5 Q9BTC8,Q86YP4,Q13330 3 +THUMP domain [IPR004114] 0.5220271613117062 0.1439705357331528 0.8855237362864528 1.0 0.956125289476382 2 Q9NXG2 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.5106030483764036 0.1426984325431272 0.8865283546985985 1.0 0.956804235295732 3 Q10471,Q86SF2 2 +Proteasomal ATPase OB C-terminal domain [IPR032501] 0.342175066312999 0.1390211430779049 0.8894334415225289 1.0 0.9587203819290256 5 P62191,P17980,P62333,P43686 4 +Histone deacetylase domain [IPR023801] 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9798250061621964 2 Q13547 1 +MoaB/Mog domain [IPR001453] 0.4862537263994851 0.1019668654044547 0.9187829755402912 1.0 0.9803945749059436 2 Q8NFF5 1 +Kinesin-like [IPR022164] 0.4836038423319085 0.0994233481138994 0.9208021454909724 1.0 0.9814658957342076 2 Q12756 1 +MHC class I-like antigen recognition-like [IPR011161] 0.4789665452136601 0.0951496629877462 0.924195951620701 1.0 0.9820629258842902 2 Q9UNN8 1 +TGS [IPR004095] 0.309121061359863 0.0927202568823657 0.9261258036701516 1.0 0.9820629258842902 6 P55039,P26639,Q9NTK5,Q9NYK5,Q9Y295 5 +EB1, C-terminal [IPR004953] 0.4756541901291953 0.092232869229562 0.9265130234693066 1.0 0.9820629258842902 2 Q15555 1 +CAP Gly-rich domain [IPR000938] 0.4746604836038557 0.0913795586404393 0.927191003627216 1.0 0.982367164059464 2 Q15813 1 +Ran binding domain [IPR000156] 0.3496851176665523 0.0897129974439354 0.9285152871266196 1.0 0.9833610320400888 4 Q9H6Z4,P43487,P49792 3 +Hyaluronan-mediated motility receptor, C-terminal [IPR031794] 0.4670420669095824 0.0851633056638809 0.9321315624006848 1.0 0.9851139860101056 2 O75330 1 +ENTH domain [IPR013809] 0.4562624254473102 0.0832304034042804 0.933668338180922 1.0 0.9855388014131956 3 Q14677,O00291 2 +AP180 N-terminal homology (ANTH) domain [IPR011417] 0.4561112951308498 0.077212079231851 0.938454832497448 1.0 0.9889511604050092 2 O00291 1 +Cyclin-like [IPR013763] 0.4393638170974094 0.0704516544375636 0.9438341790524738 1.0 0.9928486931010032 3 P14635,O95067 2 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.3290858814189643 0.0678784566647638 0.9458823882830948 1.0 0.9936379678048632 4 Q9UNH7 1 +Septin-type guanine nucleotide-binding (G) domain [IPR030379] 0.2952589262982491 0.065323056751693 0.947916784914356 1.0 0.9936379678048632 5 Q9NVA2,Q15019 2 +NIPSNAP [IPR012577] 0.4264413518886639 0.0622812804466003 0.9503388355724174 1.0 0.9947935771357268 3 Q9BPW8,Q9UFN0 2 +B3/B4 tRNA-binding domain [IPR005146] 0.4166942696257167 0.0567807476662403 0.9547198503286008 1.0 0.9947935771357268 2 Q8N1G4 1 +Dynamin, GTPase domain [IPR001401] 0.4125248508946282 0.054893360444271 0.9562234215030412 1.0 0.9947935771357268 3 P50570,O60313 2 +Beta-adaptin appendage, C-terminal subdomain [IPR015151] 0.4088800530152371 0.0531823558010725 0.9575866137494852 1.0 0.9947935771357268 3 Q10567,O00203 2 +Phospholipid/glycerol acyltransferase [IPR002123] 0.2814986737400558 0.0503141227792396 0.9598720696738134 1.0 0.9947935771357268 5 Q99943,Q8NF37,Q92604,O15228 4 +Exosome complex component, N-terminal domain [IPR025721] 0.3915203709837784 0.0491023117015131 0.9608377611601742 1.0 0.9947935771357268 2 Q9Y3B2 1 +Ribosomal protein S5, C-terminal [IPR005324] 0.3895329579331004 0.0486342125972713 0.9612108045052106 1.0 0.9947935771357268 2 P15880 1 +Ribosomal protein S5, N-terminal [IPR013810] 0.3895329579331004 0.0486342125972713 0.9612108045052106 1.0 0.9947935771357268 2 P15880 1 +S100/CaBP-9k-type, calcium binding, subdomain [IPR013787] 0.3888704869162101 0.0484821489062244 0.9613319908197676 1.0 0.9947935771357268 2 P31949 1 +PABP, RNA recognition motif 2 [IPR045305] 0.3746273600530085 0.0456565537010718 0.9635839927964118 1.0 0.9947935771357268 2 Q13310 1 +U-box domain [IPR003613] 0.2846968791428895 0.0450795861398123 0.9640438727789442 1.0 0.9947935771357268 7 Q13356 1 +FAST kinase-like protein, subdomain 2 [IPR013579] 0.3504471679364127 0.0424597304937264 0.9661322131919168 1.0 0.9947935771357268 2 Q969Z0 1 +FAST kinase leucine-rich [IPR010622] 0.3504471679364127 0.0424597304937264 0.9661322131919168 1.0 0.9947935771357268 2 Q969Z0 1 +RAP domain [IPR013584] 0.3504471679364127 0.0424597304937264 0.9661322131919168 1.0 0.9947935771357268 2 Q969Z0 1 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.3747514910536738 0.041039602650297 0.9672643240931678 1.0 0.9947935771357268 3 Q13310,O95071 2 +Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346] 0.3252732692944794 0.0406249482662086 0.967594894731004 1.0 0.9947935771357268 2 Q86YP4 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.3232858562438003 0.0405260447358496 0.9676737433970564 1.0 0.9947935771357268 2 Q5T9A4 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.3595096090125849 0.0375038787499685 0.9700832475289528 1.0 0.9950974811477497 3 Q08426,Q16836 2 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.3595096090125849 0.0375038787499685 0.9700832475289528 1.0 0.9950974811477497 3 Q08426,Q16836 2 +Myosin tail [IPR002928] 0.3545394300861448 0.0365529751679351 0.9708414388293998 1.0 0.9952137831036274 3 P35580,P35579 2 +GOLD domain [IPR009038] 0.2721314067595617 0.0320257338586456 0.974451528768598 1.0 0.9963669045160044 4 Q9H3P7,P49755 2 +HECT domain [IPR000569] 0.2742611962721371 0.0311125989205617 0.9751797420487678 1.0 0.9967112096572311 7 Q15386 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.2788434031474142 0.0298960861489292 0.9761499272565526 1.0 0.9972106215934144 3 P08670 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9b8e8198923e83d346937a06d35b93e84aec26f1 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal [IPR039148]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA lid domain [IPR041083]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADD domain [IPR025766]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATM, catalytic domain [IPR044107]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "ATRX, ADD domain [IPR041430]", "AWS domain [IPR006560]", "Abl Interactor 1, SH3 domain [IPR035725]", "Abl-interactor, homeo-domain homologous domain [IPR012849]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein Cbl, EF hand-like [IPR014741]", "Adaptor protein Cbl, N-terminal helical [IPR003153]", "Adaptor protein Cbl, PTB domain [IPR024159]", "Adaptor protein Cbl, SH2-like domain [IPR014742]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Alpha/beta hydrolase fold-3 [IPR013094]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCL-6 corepressor, PCGF1 binding domain [IPR032365]", "BCL-6 corepressor, non-ankyrin-repeat domain [IPR031628]", "BCL10, CARD domain [IPR042143]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-lactamase-related [IPR001466]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARD domain [IPR001315]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBP/p300-type histone acetyltransferase domain [IPR031162]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCD97-like, C-terminal [IPR040233]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CKK domain [IPR014797]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COQ9 [IPR013718]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CREB-binding protein/p300, atypical RING domain [IPR010303]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, N-terminal [IPR013164]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calmodulin-regulated spectrin-associated protein, CH domain [IPR022613]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cdc6, C-terminal [IPR015163]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Chaperone DnaJ, C-terminal [IPR002939]", "Checkpoint kinase 1, catalytic domain [IPR034670]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Citron homology (CNH) domain [IPR001180]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class V myosin, motor domain [IPR036103]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coactivator CBP, KIX domain [IPR003101]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dienelactone hydrolase [IPR002925]", "Dihydrofolate reductase domain [IPR001796]", "Dihydroorotate dehydrogenase domain [IPR005720]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DM14 [IPR006608]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4371 [IPR025398]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass [IPR039520]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXOG, C-terminal [IPR041003]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "EngB-type guanine nucleotide-binding (G) domain [IPR030393]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exostosin, GT47 domain [IPR040911]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM69, protein-kinase domain [IPR022049]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FOX1, RNA recognition motif [IPR034237]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Focadhesin/RST, DUF3730 [IPR022542]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fox-1 C-terminal domain [IPR025670]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Freud, C2 domain [IPR037772]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fungal lipase-like domain [IPR002921]", "Furin-like cysteine-rich domain [IPR006211]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPI ethanolamine phosphate transferase 2, C-terminal [IPR045687]", "GPI ethanolamine phosphate transferase 2, N-terminal [IPR037674]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galactosyltransferase, C-terminal [IPR027791]", "Galactosyltransferase, N-terminal [IPR027995]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin subgroup [IPR014025]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutaredoxin, eukaryotic/virial [IPR011899]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase 64 domain [IPR015338]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycosyltransferase subfamily 4-like, N-terminal domain [IPR028098]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAT, C-terminal dimerisation domain [IPR008906]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock factor (HSF)-type, DNA-binding [IPR000232]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "Hpc2-related domain [IPR014840]", "HuR, RNA recognition motif 2 [IPR034996]", "Huntingtin-interacting protein 1, clathrin-binding domain [IPR032422]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxyacylglutathione hydrolase, C-terminal domain [IPR032282]", "Hydroxyacylglutathione hydrolase, MBL domain [IPR035680]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KAP family P-loop domain [IPR011646]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Knl1, C-terminal RWD domain [IPR040850]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "L27-2 [IPR015132]", "L27-N [IPR015145]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M28 Zn-Peptidase Glutaminyl Cyclase [IPR037457]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIR motif [IPR016093]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP5, SH3 domain [IPR035601]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MST4, kinase domain [IPR035056]", "MTMR6, PH-GRAM domain [IPR035998]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Mediator complex, subunit Med12 [IPR019035]", "Mediator complex, subunit Med12, LCEWAV-domain [IPR021990]", "Mediator complex, subunit Med12, catenin-binding [IPR021989]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin 5a, cargo-binding domain [IPR037988]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, C-terminal [IPR001075]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neogenin, C-terminal [IPR010560]", "Neurexin/syndecan/glycophorin C [IPR003585]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear protein 96 [IPR021967]", "Nuclear receptor coactivator, CREB-bp-like, interlocking [IPR014744]", "Nuclear speckle splicing regulatory protein 1, N-terminal [IPR018612]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, C-terminal [IPR032630]", "P-type ATPase, N-terminal [IPR032631]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIGA, GPI anchor biosynthesis [IPR013234]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKAA2, UBA-like autoinhibitory domain [IPR028783]", "PRKCBP1, PHD finger [IPR044075]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Patatin-like phospholipase domain [IPR002641]", "Patatin-like phospholipase domain containing protein 8-like [IPR045217]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C14, p20 domain [IPR001309]", "Peptidase C14, caspase non-catalytic subunit p10 [IPR002138]", "Peptidase C14A, caspase catalytic domain [IPR015917]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S54, rhomboid domain [IPR022764]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase like 2, U-box domain [IPR026951]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein FAM210A/B-like domain [IPR009688]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein disulfide-isomerase A5, N-terminal TRX-like b domain [IPR041865]", "Protein furry, C-terminal [IPR045842]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Protocadherin [IPR013585]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative RNA-binding protein 47, RNA recognition motif 2 [IPR034440]", "Putative RNA-binding protein 47, RNA recognition motif 3 [IPR034445]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM15B, RNA recognition motif 1 [IPR034475]", "RBM15B, RNA recognition motif 2 [IPR034535]", "RBM15B, RNA recognition motif 3 [IPR034536]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM7, RNA recognition motif [IPR034500]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase II elongation factor ELL, N-terminal [IPR019464]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Receptor L-domain [IPR000494]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-activating protein, FF domain [IPR032835]", "Rho GTPase-activating protein, pG1 and pG2 domain [IPR045786]", "Rho GTPase-activating protein, pG1 domain [IPR039007]", "Rho GTPase-activating protein, pG2 domain [IPR039006]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "Rubisco LSMT, substrate-binding domain [IPR015353]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SETD3, SET domain [IPR044428]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD11, START domain [IPR041952]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Scaffold protein Nfu/NifU, N-terminal [IPR014824]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfatase-modifying factor enzyme [IPR005532]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFIIH p62 subunit, N-terminal [IPR013876]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM27, PRY/SPRY domain [IPR035791]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TUP1-like enhancer of split [IPR011494]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere repeat-binding factor, dimerisation domain [IPR013867]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Telomere-length maintenance and DNA damage repair [IPR021668]", "Telomeric repeat-binding factor 2, Rap1-binding domain [IPR031902]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tex protein, YqgF-like domain [IPR032639]", "Tex, S1 domain [IPR044146]", "Tex-like protein, N-terminal [IPR018974]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine synthase, N-terminal [IPR029144]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIIC, triple barrel domain [IPR019481]", "Transcription factor Tfb2, C-terminal domain [IPR040662]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-specific chaperone C, N-terminal [IPR031925]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Lyn, SH2 domain [IPR035852]", "Tyrosine-protein kinase Lyn, SH3 domain [IPR035748]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-N-acetylglucosamine 2-epimerase domain [IPR003331]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glycosyltransferase family, conserved site [IPR035595]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubinuclein middle domain [IPR026947]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Unconventional myosin-Ie/If, SH3 domain [IPR035507]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Upstream-binding protein 1, SAM domain [IPR037600]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting protein 36, GLUE domain [IPR021648]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 [IPR019452]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 [IPR019453]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate heat shock transcription factor, C-terminal domain [IPR010542]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZMYND8/11, PWWP domain [IPR035505]", "ZN598/Hel2, RING finger [IPR041888]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, A20-type [IPR002653]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TAZ-type [IPR000197]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, N-terminal coiled-coil domain [IPR031831]", "cGMP-dependent protein kinase, catalytic domain [IPR035014]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA decapping enzyme 2 , NUDIX hydrolase domain [IPR044099]", "mRNA decapping protein 2, Box A domain [IPR007722]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANO6", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMCX3", "ARMT1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "BAG5", "BAG6", "BAIAP2", "BAP18", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCKDK", "BCL10", "BCOR", "BCS1L", "BIRC6", "BLVRA", "BMS1", "BOP1", "BPHL", "BPTF", "BRD2", "BRD4", "BRIX1", "BROX", "BSDC1", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C1orf35", "C2CD5", "C3orf58", "CACYBP", "CAD", "CADM1", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CBL", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC97", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CDC23", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHP1", "CHRAC1", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLPB", "CLPX", "CLTC", "CLUH", "CMBL", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT2", "COA3", "COASY", "COIL", "COL4A3BP", "COMMD2", "COMMD8", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CWC27", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "CYFIP2", "DAGLB", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCP1A", "DCP2", "DCTN1", "DCUN1D1", "DCUN1D5", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHODH", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC2H1", "EARS2", "ECE1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAM208A", "FAM210B", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPS1", "GPT2", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HMBS", "HMG20A", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPBP1", "HSPH1", "HTATIP2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISOC2", "ISYNA1", "ITCH", "ITGB1", "ITPRIP", "IVD", "IWS1", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KMT2A", "KNL1", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LENG8", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRCH2", "LRIG2", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8A", "LRRC8C", "LRSAM1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED12", "MEPCE", "METAP1", "METAP2", "METTL13", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL24", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCEH1", "NCKIPSD", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFE", "NEMF", "NENF", "NEO1", "NES", "NFATC2IP", "NFS1", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIPSNAP3A", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OXCT1", "OXSR1", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDXK", "PDZD8", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF3", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPWD1", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PVR", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOX2", "RNASEH2A", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS2", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTCA", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A3", "SLC27A4", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STOML2", "STRBP", "STRIP1", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAGLN2", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TECR", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFIP11", "TFRC", "TGFBRAP1", "THNSL1", "THOC1", "THOC2", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLCD1", "TLK2", "TLN1", "TMED10", "TMED7", "TMED9", "TMEM201", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSR1", "TST", "TTC4", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXN2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBLCP1", "UBN2", "UBP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VCP", "VEZT", "VIM", "VIPAS39", "VIRMA", "VPS13C", "VPS16", "VPS18", "VPS29", "VPS36", "VPS37B", "VPS37C", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WASHC4", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WDR62", "WFS1", "WIZ", "WNK2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YBX3", "YKT6", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H13", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZFYVE26", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF148", "ZNF207", "ZNF281", "ZNF326", "ZNF512B", "ZNF598", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZYX"], "leading_proteins": ["ABRAXAS2", "ACBD3", "ACOT7", "ADD1", "AFDN", "AGAP3", "AGPAT1", "AIMP1", "ALG11", "AP1B1", "AP1M1", "AP3B1", "APRT", "ATAD3B", "ATM", "ATP2A2", "ATP2B4", "BAG6", "BIRC6", "CACYBP", "CADM1", "CARHSP1", "CCNB1", "CCNB2", "CDC34", "CERS2", "CHORDC1", "CLINT1", "CNDP2", "COL4A3BP", "COPS5", "COPS6", "CTBP1", "CTBP2", "CTPS2", "CUL1", "CUL2", "CUL5", "CWC27", "CYB5B", "DCUN1D1", "DHCR24", "DICER1", "DNAJA1", "DNM2", "DNMT1", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "ECT2", "EHD1", "EHHADH", "EIF2A", "EIF2D", "EIF3H", "ERAP1", "EWSR1", "EXOSC1", "EXOSC3", "FAM129B", "FAM49B", "FERMT2", "FKBP10", "FKBP7", "FLAD1", "FMR1", "FUBP1", "FUCA1", "FXR1", "GALNT1", "GALNT2", "GALNT7", "GATAD2A", "GCLM", "GFPT1", "GINS3", "GMPPB", "GNPAT", "HADH", "HDAC1", "HIP1", "HMMR", "HNRNPAB", "HNRNPH1", "HNRNPR", "HPRT1", "ISOC2", "KDM1B", "KHDRBS1", "KHSRP", "KIF1A", "LGALS3BP", "LMAN1", "LNPEP", "LPCAT1", "LPGAT1", "LRRC47", "LTA4H", "MAPRE2", "METTL13", "METTL7B", "MFN1", "MFN2", "MFSD10", "MICU1", "MON2", "MORC2", "MPP2", "MRPL39", "MRPL45", "MSH6", "MSN", "MTA1", "MTA3", "MYH10", "MYH9", "MYL6", "MYO5A", "MYO6", "NCLN", "NECAP1", "NFATC2IP", "NHP2", "NIPSNAP1", "NIPSNAP3A", "NOB1", "NONO", "NUCB1", "NUCB2", "NUDCD2", "OCRL", "OLA1", "OPA1", "OSBP", "PABPC4", "PANK4", "PARP2", "PATJ", "PCBP2", "PDCD6IP", "PDE12", "PDLIM1", "PFKL", "PGRMC2", "PHGDH", "PIGA", "PIK3C2A", "POLD1", "POLE", "PPAT", "PPIL2", "PPIL3", "PROCR", "PRPSAP2", "PSMA6", "PSMC1", "PSMC3", "PSMC4", "PSMC6", "PSMD14", "PSMD7", "PSME2", "PSME3", "PSPC1", "PTBP2", "PTGES3", "PTPMT1", "PTPRF", "QARS", "QKI", "RANBP1", "RANBP2", "RANBP3", "RAPGEF2", "RDX", "RPL27A", "RPL30", "RPS2", "RPS4X", "RTN4", "S100A11", "SAE1", "SDCBP", "SDHB", "SEC23A", "SEL1L", "SEPT11", "SEPT2", "SLC37A4", "SLC4A7", "SMARCAD1", "SNU13", "SNX6", "SNX9", "SSRP1", "STAMBP", "SUCLG1", "SYNGR2", "TARS", "TBC1D9B", "TBCE", "TBRG4", "TFRC", "TGFBRAP1", "THUMPD1", "TMED10", "TRAM1", "TRIM21", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE2K", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBR2", "UBR4", "UBR5", "USP11", "USP15", "USP19", "USP47", "USP48", "VIM", "YBX3", "YWHAB", "YWHAE", "YWHAH", "YWHAZ", "ZC3HAV1", "ZMYM1"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..804961ded8809585d7eb1834ceff02fd83c43c45 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tubulin [IPR000217]", "1": "Beta tubulin [IPR002453]", "2": "Proteasome, subunit alpha/beta [IPR001353]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c080abf194769ba27e3cee39af2df7a49af08562 --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7db96e87d3a2ff5de10155d3f1ebbce86174e557c2c15e3df867d5f03098bc64 +size 176319 diff --git a/interpro_family/advanced/plot_1.png b/interpro_family/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..37fdc5046eb9e5894f8ff088214b417acfc005e5 --- /dev/null +++ b/interpro_family/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:350a767b9946003909465f94641a6ee1fa614b6f60d8122c131555013a10e197 +size 177318 diff --git a/interpro_family/advanced/plot_2.png b/interpro_family/advanced/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..f79b3c4ec0932232336261e4de80d61bef13d01a --- /dev/null +++ b/interpro_family/advanced/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:58fcbe7e8ea41a19f6876572aac79b1a5c4b950e96c1e94a40aa3de547b8478a +size 188200 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f990eedc58b4f54d014a7b769c4767faf31d0e45 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tubulin [IPR000217]", "1": "Beta tubulin [IPR002453]", "2": "Proteasome, subunit alpha/beta [IPR001353]", "3": "26S proteasome regulatory subunit P45-like [IPR005937]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..0a5e049d537d4e05d6f672461418a5f220b93f7a --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:478279d2c2a75935cf7878de064d40641217cf9927856331925357a312fb7fa7 +size 132717 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..b23c16d1e4a5e3057a730a3a8e8fc0866b3e68ea --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:81063740dfa36845ba0340a4d2b0af8457e8798f1879370f1b9b9701b9f17b6f +size 135338 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..2c9ac683a7eae5e863daf723f97be7d61b84fde3 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e865368c85fb40c034594e6384174164d2122ba6cb46f39583a468c28d0693a6 +size 140682 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..aee13582a41407fbf826a01e8245b4aa8579103d --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:53a34ce80e89d9a7f2f6826d63cab14c0e55263b2239ff8843e42ccbd3b728cc +size 145676 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..e631497027d3c31306b0c5a05de4581e1545f7b1 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c8521a00291e3316be2220a5b90fb0e3bc38f19f31f97aa5377128178bb5409a +size 360414 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f98a7893ecc1531db7628d79578f1cb6b6638ad8 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tubulin [IPR000217] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +Beta tubulin [IPR002453] 6 7 2.730276917747799 0.0063281145339988 3.5533980582524274 5.54126213592233 0.5823511994709325 0.3808337519133083 1.5578062452886454 0.9632803779920796 1.1906256051626651 0.3058955364405814 3.40260461815712e-08 5.354324033305364e-08 2.1615500006651521e-13 1.5998774522859254e-10 2.1037423825620157e-08 +Proteasome B-type subunit [IPR023333] 4 6 2.2610148952796805 0.0237583347066459 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 1.0 0.0832836732680532 3.9104524570814734e-05 2.915330495677531e-05 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666] 2 5 2.1514158334855265 0.0314433925552211 1.3015075376884422 2.7839195979899496 -0.0337335374461129 0.5032440164750671 1.077195194068414 1.2793460615854924 1.1768089916697049 0.3292544364711594 1.0 1.0 1.0 0.0001371292862649 0.0010757702174933 +Proteasome, subunit alpha/beta [IPR001353] 6 13 2.086750253104653 0.0369107160862447 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 1.0 1.0 0.1432798584585485 2.867880480409346e-05 4.949573022786166e-06 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d32558f16a17fc7af61dab5032e6466ccb60a67e --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 2341, + "title": "Average number of proteins per term", + "value": 1.2785134557881248 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..08698d38813db10dcc6585373e14c4a791fbcf70 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..336c512d97d193f86da159e1e4a371042920fa48 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,105 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tubulin [IPR000217] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9999996485461832 0.1139679417552191 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Beta tubulin [IPR002453] 0.9721300597212992 2.730276917747799 0.0063281145339988 0.9999996485461832 0.1139679417552191 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Proteasome B-type subunit [IPR023333] 0.8607724193811946 2.2610148952796805 0.0237583347066459 1.0 0.1255535372105877 6 P20618,P49720,P49721,P28070 4 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666] 0.8677158765585119 2.1514158334855265 0.0314433925552211 1.0 0.1381031556693669 5 Q6UX04,Q9H2H8 2 +Eukaryotic porin/Tom40 [IPR027246] 0.940392357563118 2.095861531619454 0.0360944760523147 1.0 0.1459669395654072 4 P21796 1 +Proteasome, subunit alpha/beta [IPR001353] 0.6875809506975922 2.086750253104653 0.0369107160862447 1.0 0.1472260343054537 13 P60900,P49720,P28070,P28074,P20618,P49721 6 +Major facilitator superfamily [IPR011701] 0.908186940669538 1.9730840566193424 0.0484859864158662 1.0 0.1669201385287394 4 Q14728,O43826,Q96ES6 3 +Haem oxygenase [IPR002051] 0.9963564094070884 1.7009111707539326 0.0889596686751463 1.0 0.2324269914827205 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.9963564094070884 1.7009111707539326 0.0889596686751463 1.0 0.2324269914827205 2 P30519 1 +ThiF/MoeB/HesA family [IPR045886] 0.7275526756901377 1.700058098886973 0.089119997763325 1.0 0.2325786689090356 6 Q9UBE0 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.725769803238549 1.692347613683864 0.0905797144251179 1.0 0.2343112036114021 6 Q9NZ08,Q9UIQ6,P09960 3 +CD36 family [IPR002159] 0.9940377608479628 1.6917268973984696 0.0906980574917213 1.0 0.2343533693025603 2 Q14108 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9887379927128191 1.6707259831448285 0.0947758142064552 1.0 0.2416886503892283 2 Q99595 1 +Protein arginine N-methyltransferase [IPR025799] 0.7486737400530581 1.662408513361148 0.0964308930882471 1.0 0.243784795593506 5 Q86X55,O60678,Q6P2P2,Q99873 4 +Nucleobindin [IPR040250] 0.9751573368665124 1.6168660824883845 0.1059071911665048 1.0 0.2590686881094961 2 P80303 1 +Aminopeptidase N-type [IPR034016] 0.8046787980931807 1.570062029025894 0.1164006812335762 1.0 0.2719652254970749 4 Q9UIQ6 1 +Mpv17/PMP22 [IPR007248] 0.9632328585624388 1.5695349927470004 0.1165233324107501 1.0 0.2719652254970749 2 Q9NR77 1 +Sulfotransferase [IPR005331] 0.9582643259357404 1.5498069084979356 0.1211878683763387 1.0 0.2786844792426415 2 Q8NCH0 1 +Mitochondrial carrier UCP-like [IPR002030] 0.955614441868169 1.5392843027372507 0.1237349044231135 1.0 0.2823230129186245 2 Q9H2D1 1 +Porin, eukaryotic type [IPR001925] 0.9603715355755243 1.4815122487598895 0.1384701233636356 1.0 0.3028662767872001 3 P21796 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9572564612326092 1.4702587155488924 0.1414916977903373 1.0 0.307610380247256 3 Q9HB40,P10619 2 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9307717787346826 1.440643679448076 0.1496853737090848 1.0 0.31952116461938 2 Q5VW38 1 +Cytochrome c oxidase subunit VII [IPR039297] 0.9105664127194448 1.3605173160821844 0.1736662770177723 1.0 0.3486730313024057 2 P14406 1 +Cytochrome c oxidase subunit VIIa, metazoa [IPR003177] 0.9105664127194448 1.3605173160821844 0.1736662770177723 1.0 0.3486730313024057 2 P14406 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9082477641603188 1.351333914348577 0.1765884927826686 1.0 0.3512265604114081 2 Q93050 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9082477641603188 1.351333914348577 0.1765884927826686 1.0 0.3512265604114081 2 Q93050 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.9032792315336238 1.3316656051490767 0.1829700963156184 1.0 0.3590385544634222 2 Q96KA5 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.9032792315336238 1.3316656051490767 0.1829700963156184 1.0 0.3590385544634222 2 Q96KA5 1 +Defective-in-cullin neddylation protein [IPR014764] 0.8999668764491562 1.3185620529008295 0.1873155670096644 1.0 0.3641524367897465 2 Q96GG9 1 +HnRNP-L/PTB [IPR006536] 0.7310795732339761 1.2783920439798189 0.2011112278942441 1.0 0.3821439809256702 4 Q9UKA9 1 +Glycoside hydrolase, family 29 [IPR000933] 0.8893673401788673 1.2766848589950823 0.2017135290397012 1.0 0.3825890418268336 2 P04066 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.8893673401788673 1.2766848589950823 0.2017135290397012 1.0 0.3825890418268336 2 P04066 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.8804239814508111 1.2414267316192065 0.2144481491200389 1.0 0.3949827829189702 2 O75915 1 +Derlin [IPR007599] 0.8698244451805275 1.1997482685817362 0.2302371206723097 1.0 0.4121752042433076 2 Q9GZP9 1 +Bicarbonate transporter, eukaryotic [IPR003020] 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.4376458497630998 2 Q9Y6M7 1 +Clathrin adaptor, mu subunit [IPR001392] 0.8402632326013523 1.0499294164348274 0.2937505657564587 1.0 0.48325374169773 3 Q9BXS5 1 +Cytochrome P450 [IPR001128] 0.8261013580655895 1.0295996305404629 0.3031979887749032 1.0 0.4929072859180892 2 Q16850 1 +C-terminal binding protein [IPR043322] 0.8254388870486933 1.02704990173493 0.3043969670459703 1.0 0.4936968870704152 2 Q13363 1 +Ribosomal protein L22/L17 [IPR001063] 0.8171579993375331 0.99526638859114 0.3196067204636836 1.0 0.5081764365744288 2 Q9NWU5 1 +CTP synthase [IPR004468] 0.8015899304405496 0.935998825249121 0.3492737925583768 1.0 0.5352153399596395 2 Q9NRF8 1 +Mrp/NBP35 ATP-binding protein [IPR019591] 0.7989400463729739 0.9259802618540276 0.3544562379933971 1.0 0.5402226908480094 2 Q8TB37 1 +Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756] 0.7989400463729739 0.9259802618540276 0.3544562379933971 1.0 0.5402226908480094 2 Q8TB37 1 +Peptidase M20 [IPR002933] 0.7966213978138501 0.9172318496872116 0.3590211604308266 1.0 0.5453752404459171 2 Q96KP4 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.7880092745942409 0.8848904261737482 0.3762157320848436 1.0 0.5616843295986089 2 Q14739 1 +F-actin-capping protein subunit alpha [IPR002189] 0.7853593905266676 0.8749898831754436 0.381579410394762 1.0 0.5668003805419657 2 P47755 1 +Nonaspanin (TM9SF) [IPR004240] 0.7748404710327714 0.8225293056935726 0.4107757147647572 1.0 0.5921342045962419 3 Q9HD45 1 +Adaptor protein complex, sigma subunit [IPR016635] 0.759854256376288 0.7810717330714503 0.4347603060245943 1.0 0.6123789870057614 2 Q92572 1 +Dynein light chain, type 1/2 [IPR001372] 0.757204372308716 0.771471057957619 0.4404277708767039 1.0 0.6162829716810304 2 P63167 1 +TB2/DP1/HVA22-related protein [IPR004345] 0.7425447316103356 0.7147499405143948 0.4747635726792332 1.0 0.6412949281874069 3 Q00765,Q96HR9 2 +Profilin [IPR005455] 0.7366677707850333 0.698221034814921 0.4850389736363212 1.0 0.6491881317448602 2 P07737 1 +Profilin1/2/3, vertebrate [IPR005454] 0.7366677707850333 0.698221034814921 0.4850389736363212 1.0 0.6491881317448602 2 P07737 1 +DNA-directed DNA polymerase, family B [IPR006172] 0.7276341948310205 0.6663779743528068 0.5051695372093903 1.0 0.6625220653261528 3 Q07864,P28340 2 +DNA mismatch repair MutS family [IPR045076] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.6690667057637767 3 P52701 1 +Prefoldin beta-like [IPR002777] 0.7220934084133879 0.6476149615467616 0.5172340179402077 1.0 0.6690667057637767 2 O15212 1 +TAF15/EWS/TLS family [IPR034870] 0.7151981111108227 0.6268192484521398 0.5307777246443701 1.0 0.6792422201422179 3 Q01844 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.7045379264657236 0.5883968966707179 0.5562659202707398 1.0 0.695765612503376 2 P31689 1 +Macrophage migration inhibitory factor [IPR001398] 0.7005631003643656 0.575276865750702 0.565104064848112 1.0 0.7029270009614401 2 P14174 1 +Cullin [IPR045093] 0.4841424576741173 0.561837070345592 0.574227032515368 1.0 0.7078807178085711 5 Q13616,Q13617 2 +Microtubule associated protein 1 [IPR026074] 0.6899688013130085 0.5490670364363708 0.5829594459321632 1.0 0.7130136169943543 3 P78559 1 +Chaperone DnaJ [IPR012724] 0.6769724442500832 0.5104835152455626 0.609712760643192 1.0 0.7271205158765728 3 P31689 1 +Mitofusin family [IPR027094] 0.6763829082477717 0.4980022353832314 0.6184824666122921 1.0 0.7319855684223336 2 Q8IWA4 1 +14-3-3 protein [IPR000308] 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 0.740600457013976 5 P62258,P31946,P63104,Q04917 4 +Oxysterol-binding protein [IPR000648] 0.5105420624235573 0.4534930880290335 0.6501937193845961 1.0 0.7512850429809178 4 P22059 1 +Dephospho-CoA kinase [IPR001977] 0.6439218284200154 0.4020268579544018 0.6876642602749423 1.0 0.7691949636743074 2 Q8WVC6 1 +Mesoderm induction early response protein/metastasis-associated protein [IPR040138] 0.6315440689198109 0.3849410301843258 0.7002811061408951 1.0 0.7778198329391647 3 Q9BTC8,Q13330 2 +Ezrin/radixin/moesin [IPR011174] 0.6298873426109969 0.380668018434702 0.703449602854402 1.0 0.7791385209208361 3 P35241,P26038 2 +NudC family [IPR037898] 0.6349784696919603 0.3773429838610443 0.7059187325536365 1.0 0.7802435093994632 2 Q8WVJ2 1 +Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309] 0.6306724080821559 0.3657491145468312 0.7145522934423241 1.0 0.7838645355897286 2 P62241 1 +ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.8062702443683639 3 P17858 1 +ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.8062702443683639 3 P17858 1 +ATP-dependent 6-phosphofructokinase [IPR022953] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.8062702443683639 3 P17858 1 +Proteasome activator PA28 [IPR009077] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.8168224045787973 3 Q9UL46,P61289 2 +Proteasome alpha-type subunit [IPR023332] 0.3867301755768978 0.284521332677951 0.7760108881596492 1.0 0.8212664960134444 7 P60900 1 +Ribose-phosphate pyrophosphokinase [IPR005946] 0.573699900629359 0.2317526501890879 0.8167301354784426 1.0 0.8527944902564828 2 O60256 1 +Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492] 0.5606361829025798 0.2247600592149869 0.8221659392118719 1.0 0.8572100750861013 3 P55769,Q9NX24 2 +H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415] 0.5687313680026617 0.2218824217853709 0.8244054148578532 1.0 0.8585111548853356 2 P55769 1 +Haloacid dehalogenase-like hydrolase [IPR041492] 0.5664127194435363 0.2173799483961534 0.8279122564550092 1.0 0.8610140348117177 2 Q9BSH5 1 +HAD hydrolase, subfamily IA [IPR006439] 0.5664127194435363 0.2173799483961534 0.8279122564550092 1.0 0.8610140348117177 2 Q9BSH5 1 +KH domain-containing BBP-like [IPR045071] 0.5551080513850001 0.2143801442304279 0.8302506243403724 1.0 0.8630624829399698 3 Q07666 1 +26S proteasome regulatory subunit P45-like [IPR005937] 0.3422885572139268 0.1619843362830769 0.8713181887979979 1.0 0.9013503667592192 6 P62191,P35998,P17980,P43686,P62333 5 +Cytoplasmic FMR1-interacting [IPR008081] 0.5021530308049167 0.1188322778361046 0.9054082358458097 1.0 0.9320847318008092 2 Q7L576 1 +Tumour protein D52 [IPR007327] 0.4968532626697729 0.112899204400297 0.9101104670955728 1.0 0.9361021983614832 2 P55327 1 +Histone deacetylase [IPR003084] 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9408275047072124 2 Q13547 1 +Histone deacetylase family [IPR000286] 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9408275047072124 2 Q13547 1 +Microtubule-associated protein RP/EB [IPR027328] 0.4756541901291953 0.092232869229562 0.9265130234693066 1.0 0.9483895880811748 2 Q15555 1 +Ran binding protein RanBP1-like [IPR045255] 0.3496851176665523 0.0897129974439354 0.9285152871266196 1.0 0.9491598879843924 4 Q9H6Z4,P43487,P49792 3 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.2820674688642571 0.0892448061330866 0.9288873572713554 1.0 0.9491598879843924 19 Q96LJ7,Q3SXM5 2 +Glycogen/starch/alpha-glucan phosphorylase [IPR011833] 0.4614110632659981 0.0809287808068452 0.9354985912561082 1.0 0.9542493255470804 2 P11216 1 +Glycosyl transferase, family 35 [IPR000811] 0.4614110632659981 0.0809287808068452 0.9354985912561082 1.0 0.9542493255470804 2 P11216 1 +Prefoldin alpha-like [IPR004127] 0.4547863530970683 0.076322497592878 0.939162527554074 1.0 0.9575694586254736 2 Q99471 1 +Septin [IPR016491] 0.2952589262982491 0.065323056751693 0.947916784914356 1.0 0.9652942869575022 5 Q9NVA2,Q15019 2 +Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060] 0.4166942696257167 0.0567807476662403 0.9547198503286008 1.0 0.969630876190566 2 Q8N1G4 1 +Dynamin [IPR022812] 0.4125248508946282 0.054893360444271 0.9562234215030412 1.0 0.9701726200116716 3 P50570,O60313 2 +AP-1/2/4 complex subunit beta [IPR016342] 0.408744617422999 0.0539770220092467 0.956953471327457 1.0 0.9702157108607956 2 Q10567 1 +AP complex subunit beta [IPR026739] 0.4088800530152371 0.0531823558010725 0.9575866137494852 1.0 0.9704373431980716 3 Q10567,O00203 2 +Ribosomal protein S5 [IPR000851] 0.3895329579331004 0.0486342125972713 0.9612108045052106 1.0 0.9730226473814456 2 P15880 1 +Ribosomal protein S15 [IPR000589] 0.3786021861543666 0.0463641985133989 0.9630199712579748 1.0 0.9739853744112262 2 P62277 1 +Lysosome-associated membrane glycoprotein [IPR002000] 0.3749585955614539 0.045713294447204 0.9635387674509316 1.0 0.9739853744112262 2 P13473 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.3746273600530085 0.0456565537010718 0.9635839927964118 1.0 0.9739853744112262 2 Q13310 1 +Exportin-1/5 [IPR045065] 0.3421662802252503 0.0417208650804789 0.9667212205124532 1.0 0.9760121642794092 2 Q9HAV4 1 +ATPase family AAA domain-containing protein ATAD2-like [IPR045199] 0.3279231533620512 0.0407656590517479 0.9674827166957018 1.0 0.9760121642794092 2 Q9ULI0 1 +Transcriptional repressor p66 [IPR040386] 0.3252732692944794 0.0406249482662086 0.967594894731004 1.0 0.9760121642794092 2 Q86YP4 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.3232858562438003 0.0405260447358496 0.9676737433970564 1.0 0.9760121642794092 2 Q5T9A4 1 +ADF/Cofilin [IPR017904] 0.2978793903247135 0.0306146233445394 0.9755768798740818 1.0 0.98271319956335 3 Q9Y281,P23528 2 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..90044edb78fac022052885179c03224fdf62297a --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 [IPR039210]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S26 [IPR026140]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5'-deoxynucleotidase YfbR/HDDC2 [IPR039356]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ABI family [IPR028457]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor 6 [IPR041838]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1 complex subunit sigma [IPR044733]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP synthase-coupling factor 6, mitochondrial [IPR008387]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "Abl interactor 1 [IPR028456]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-histidine N-methyltransferase SETD3 [IPR025785]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein Cbl [IPR024162]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Anion exchange protein 2 [IPR002978]", "Anion exchange protein [IPR001717]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylacetamide deacetylase [IPR017157]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2 [IPR033093]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell lymphoma/leukemia 10/E10 [IPR033238]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-galactosyltransferase [IPR003859]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biorientation of chromosomes in cell division protein 1-like 1 [IPR043244]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 11 [IPR019312]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD166 antigen [IPR039810]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC50/LEM3 family [IPR005045]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 2 [IPR037354]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "CPSF complex subunit CPSF4-like [IPR045348]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calmodulin-regulated spectrin-associated protein [IPR032940]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Carboxymethylenebutenolidase homolog [IPR042946]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Caspase-3/7 [IPR015471]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Ccdc97-like [IPR018613]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc42-interacting protein 4 [IPR028498]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle control protein 50A [IPR030351]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein Cdc6/18 [IPR016314]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein U [IPR025214]", "Ceramide glucosyltransferase [IPR025993]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin modification-related protein Eaf6 [IPR015418]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil and C2 domain-containing protein 1 [IPR039725]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 1 [IPR033370]", "Conserved oligomeric Golgi complex subunit 8 [IPR007255]", "Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae [IPR016632]", "Conserved oligomeric Golgi complex, subunit 3 [IPR007265]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cys/Met metabolism, pyridoxal phosphate-dependent enzyme [IPR000277]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase assembly protein COX14 [IPR029208]", "Cytochrome c oxidase assembly protein CtaG/Cox11 [IPR007533]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIa-related, mitochondrial [IPR017267]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Dehydrogenase/reductase SDR member 4-like [IPR029511]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxyhypusine synthase [IPR002773]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydroorotate dehydrogenase, class 2 [IPR005719]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dim1 family [IPR004123]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "Divalent ion tolerance protein, CutA [IPR004323]", "Divergent protein kinase domain 2A/B [IPR020519]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 3 [IPR008568]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelial protein C receptor [IPR015669]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin receptor type-A /type-B [IPR016257]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Erbin [IPR032927]", "Erg28 [IPR005352]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exostosin-2 [IPR027673]", "Exostosin-like [IPR004263]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Focadhesin [IPR021392]", "Focadhesin/RST1 [IPR045163]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein alpha subunit, group Q [IPR000654]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPI ethanolamine phosphate transferase 2 [IPR039527]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI-anchor transamidase [IPR028361]", "GPN-loop GTPase 1 [IPR030230]", "GPN-loop GTPase [IPR004130]", "GRIM-19 [IPR009346]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein, ribosome biogenesis, YsxC [IPR019987]", "Galactokinase [IPR000705]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glu-tRNAGln amidotransferase C subunit [IPR003837]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutaminyl-peptide cyclotransferase-like [IPR040234]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor Ect2 [IPR026817]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "H/ACA ribonucleoprotein complex, subunit Nop10 [IPR007264]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Heat shock transcription factor family [IPR027725]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group nucleosome-binding domain-containing protein 5 [IPR040164]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase Rtt109/CBP [IPR013178]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase EHMT2 [IPR038034]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Huntingtin-interacting protein 1 [IPR030554]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxyacylglutathione hydrolase [IPR017782]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol 1,4,5-trisphosphate receptor-interacting protein [IPR024797]", "Inositol 1,4,5-trisphosphate receptor-interacting protein family [IPR026250]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 2 [IPR029321]", "Integrator complex subunit 2, metazoa [IPR026236]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrator complex subunit 9 [IPR027074]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intermembrane space protein MIX23 [IPR019171]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isochorismatase domain-containing protein 2 [IPR040318]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF15/KIN-12E [IPR044986]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF20B [IPR028828]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore scaffold 1 [IPR037388]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "L-type amino acid transporter [IPR004760]", "LAMTOR1/MEH1 [IPR028209]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Leo1-like protein [IPR007149]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat-containing 41 [IPR026137]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lon protease [IPR027065]", "Lon protease homologue 2, peroxisomal [IPR027501]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "METTL16/RlmF family [IPR010286]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MICRORCHIDIA ATPase family [IPR045261]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannosyltransferase ALG2 [IPR027054]", "Mediator complex, subunit Med17 [IPR019313]", "Mediator complex, subunit Med21 [IPR021384]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylmalonic aciduria and homocystinuria type C family [IPR032037]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase METTL16/PsiM [IPR017182]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate kinase [IPR006205]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microtubule associated protein 1 [IPR026074]", "Microtubule associated protein 1A [IPR015656]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase 1, beta subcomplex, subunit 6 [IPR019174]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Nck-associated protein 1 [IPR019137]", "Negative elongation factor E [IPR033102]", "Neogenin [IPR033024]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Non-specific endonuclease [IPR040255]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear pore protein POM121 [IPR026090]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear speckle splicing regulatory protein 1 [IPR042816]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase 6 [IPR037994]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "Nurim-like [IPR033580]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "P-type ATPase, subfamily IV [IPR006539]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PDZ domain-containing protein 8 [IPR039275]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PEX5/PEX5L [IPR024111]", "PH-interacting protein [IPR028738]", "PHD finger protein 10 [IPR038045]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C14 family [IPR002398]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisomal targeting signal 1 receptor PEX5, animals [IPR024113]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 [IPR042165]", "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like [IPR044596]", "Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3 [IPR039507]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phospholipid-transporting ATPase IG [IPR030363]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polycomb protein EED [IPR037352]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor Isy1 [IPR009360]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Pre-rRNA-processing protein TSR2 [IPR019398]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase 3 [IPR039839]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein C10 [IPR026317]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM210A/B-like [IPR045866]", "Protein FAM8A1 [IPR039871]", "Protein Hgh1 [IPR039717]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG1 [IPR030693]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein suppressor of sable-like [IPR045124]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA-binding protein 47 [IPR034442]", "Putative ribosome-binding factor A, mitochondrial [IPR039212]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein Fox-1 [IPR017325]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II elongation factor ELL [IPR031184]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "ROK family [IPR000600]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab11-family interacting protein class I [IPR037789]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab39 [IPR041818]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Refilin family [IPR028215]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein 3 [IPR013970]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulophagy receptor 1/3 [IPR043384]", "Reticulophagy regulator 3 [IPR033361]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rhotekin [IPR030471]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease P protein subunit Rpp29/RNP1 [IPR002730]", "Ribonuclease P/MRP subunit Rpp29 [IPR016848]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22, bacterial/chloroplast-type [IPR005727]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding factor A [IPR000238]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Root UVB sensitive family [IPR006968]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SIN3-HDAC complex-associated factor [IPR026065]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "SPRY domain-containing protein 7 [IPR035766]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sdc1/DPY30 [IPR037856]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 6 [IPR030644]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 2-like [IPR034893]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase ATM/Tel1 [IPR015519]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase TOUSLED-like 2 [IPR027086]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shikimate kinase/Threonine synthase-like 1 [IPR000623]", "Shikimate kinase/gluconokinase [IPR031322]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sla2 family [IPR030224]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Snf8/Vps36 family [IPR040608]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 27 member 3 [IPR030307]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermatogenesis-defective protein 39 [IPR040057]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Spindle and kinetochore-associated protein 1 [IPR009829]", "Spindle and kinetochore-associated protein 3 [IPR033341]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar phosphate transporter [IPR000849]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntaxin-3 [IPR031186]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TEL2-interacting protein 1 [IPR016441]", "TFIIH subunit Tfb1/GTF2H1 [IPR027079]", "TFIIIC subunit GTF3C6-like [IPR042771]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM70 family [IPR009724]", "TMEM70/TMEM186/TMEM223 protein family [IPR045325]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPMT family [IPR008854]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Telomeric repeat-binding factor 1/2 [IPR017357]", "Telomeric repeat-binding factor 2 [IPR030657]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thiopurine S-methyltransferase [IPR025835]", "Thioredoxin [IPR005746]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine synthase-like [IPR004450]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Spt20 [IPR021950]", "Transcription factor TFIIB [IPR000812]", "Transcription factor TFIIH subunit p52/Tfb2 [IPR004598]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor TAFII31 [IPR003162]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription termination factor, mitochondrial/chloroplastic [IPR003690]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulator TACO1-like [IPR002876]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translation machinery-associated protein 16 [IPR021346]", "Translational activator Gcn1 [IPR033173]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone C [IPR027684]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase [IPR002591]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-protein kinase, insulin-like receptor [IPR016246]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing [IPR020004]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronosyl/UDP-glucosyltransferase [IPR002213]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubinuclein-2 [IPR026943]", "Ubiquinol-cytochrome c chaperone, CBP3 [IPR007129]", "Ubiquinol-cytochrome c chaperone/UPF0174 [IPR021150]", "Ubiquinone biosynthesis O-methyltransferase [IPR010233]", "Ubiquinone biosynthesis protein COQ9 [IPR012762]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised protein family UPF0687 [IPR026794]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting protein 36 [IPR037855]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vam6/VPS39/TRAP1 family [IPR032914]", "Vang-like protein [IPR009539]", "Vasodilator-stimulated phosphoprotein [IPR034367]", "Vasodilator-stimulated phosphoprotein/ENA/VASP-like [IPR017354]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WASH complex subunit 7 [IPR027307]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat HIR1 [IPR031120]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat and coiled-coil-containing protein family [IPR028041]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YIP1 family member 3 [IPR026637]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein 26 [IPR028730]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 638 [IPR033096]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "cGMP-dependent kinase [IPR002374]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor GLE1-like [IPR012476]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA splicing factor Cwf18-like [IPR013169]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB [IPR006463]", "tRNA-specific 2-thiouridylase [IPR004506]", "von Willebrand factor A domain-containing protein 8 [IPR039891]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFIP1", "ARFIP2", "ARHGAP5", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2", "ATXN2L", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BUD31", "BYSL", "C12orf43", "C12orf57", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C2orf49", "C3orf58", "C5orf15", "C5orf51", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASP7", "CAST", "CBL", "CBR1", "CBX3", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC134", "CCDC138", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC97", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC37", "CDC40", "CDC42", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDKAL1", "CDV3", "CEBPZ", "CELF2", "CENPB", "CENPF", "CENPU", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHD8", "CHERP", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COA7", "COASY", "COG1", "COG3", "COG8", "COIL", "COLGALT1", "COMMD2", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF2", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC27", "CWF19L1", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPH2", "DPH5", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "ENDOD1", "ENO1", "ENSA", "EP300", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM120B", "FAM129B", "FAM162A", "FAM210B", "FAM213A", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOCAD", "FOXC1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GCAT", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRIPAP1", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDHD2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTT", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS7", "INTS9", "IPO4", "IPO5", "IRS4", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNL1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD3", "LENG8", "LEO1", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LNPEP", "LNPK", "LONP1", "LONP2", "LRPAP1", "LRPPRC", "LRRC41", "LRRC47", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL16", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MON2", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA25", "NAA40", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "ND1", "NDC1", "NDRG1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF1", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NELFB", "NELFCD", "NELFE", "NEO1", "NES", "NFS1", "NGDN", "NHP2", "NIP7", "NIPBL", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRM", "NRP1", "NSA2", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PATL1", "PBDC1", "PBRM1", "PC", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PKP2", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIE", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP5C", "PPT1", "PPT2", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTRH2", "PUDP", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM47", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETREG3", "REXO4", "RFC1", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTFDC1", "RTKN", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC37A4", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPCS2", "SPCS3", "SPECC1L", "SPR", "SPRYD7", "SPTBN1", "SPTBN2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF2", "SRSF6", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAT1", "STIP1", "STMN1", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", 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b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 6 8 2.866298653686689 0.0041530224738759 3.7524271844660193 6.847087378640777 0.510735400099038 0.3891602594566672 2.000453572849188 1.1755668998633355 1.2190917823770269 0.3170422836523225 1.0151156465336615e-06 1.591115842977297e-06 2.7972155330238156e-10 1.8173396906145925e-07 1.9173699754060086e-05 +Tubulin/FtsZ, C-terminal [IPR008280] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 4.810555546747278e-07 7.549066083823834e-07 6.501934887842643e-11 4.3925099726703824e-08 4.949573022786166e-06 +Tubulin, C-terminal [IPR023123] 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +Mitochondrial carrier domain superfamily [IPR023395] 9 21 2.10722706689928 0.035097901800964 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 1.0 0.0513963234576887 0.0021298798430701 0.0004087345815453 +Glycoside hydrolase superfamily [IPR017853] 7 15 2.022148859610936 0.0431609756766182 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 0.1041819332558558 0.1155957163384056 0.0255840399150975 2.981587410190768e-05 2.182274869409074e-06 +Ubiquitin-like domain superfamily [IPR029071] 5 35 1.9792706749672972 0.0477855394194686 11.74757281553398 41.27427184466019 -0.211476259581958 0.623848045693968 5.827984791515399 5.973649110308603 0.7649250476398386 0.2908772909022708 0.113401922728827 0.1357968236714454 0.1449031461986719 0.1171170078758993 0.5067511948792562 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..05008782517fd8d10392250306c9182ff18c2a04 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 959, + "title": "Average number of proteins per term", + "value": 4.747653806047967 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..93d0f75c27c5d721166ad2a54ecdc0e3506999c8 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..087ce0620a7525b0f4c42df337bff2819e4b0975 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,138 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.9672026180181742 2.8662986536866892 0.0041530224738759 0.9815195478068344 0.1743047447718957 8 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Tubulin/FtsZ, C-terminal [IPR008280] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9977299304852154 0.1743047447718957 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9977299304852154 0.1743047447718957 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Tubulin, C-terminal [IPR023123] 0.972130059721299 2.730276917747799 0.0063281145339988 0.9977299304852154 0.1743047447718957 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Mitochondrial carrier domain superfamily [IPR023395] 0.6061638159259657 2.10722706689928 0.035097901800964 0.9999999999999988 0.2530743445648461 21 Q9BSK2,Q9UBX3,Q9NZJ7,Q9H2D1,Q9Y6C9,Q9BQT8,Q70HW3,Q9Y619,O43772 9 +Porin domain superfamily [IPR023614] 0.940392357563118 2.095861531619454 0.0360944760523147 0.9999999999999996 0.2583179293594764 4 P21796 1 +Glycoside hydrolase superfamily [IPR017853] 0.6525346104423778 2.022148859610936 0.0431609756766182 1.0 0.2913590601216229 15 P10253,O60502,P04062,P16278,P04066,P54802,P08236 7 +Ubiquitin-like domain superfamily [IPR029071] 0.5370173171506355 1.9792706749672977 0.0477855394194686 1.0 0.2996599573498155 35 P46379,O00443,Q96K76,Q9NZ01,Q9Y4G8 5 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.6258370796134941 1.9234728481517345 0.0544206932291777 1.0 0.3143942458239847 16 P60900,P49720,P49721,P28070 4 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.7723912696713852 1.892332818537432 0.0584466509133423 1.0 0.3247218683914501 6 O15173,O43169 2 +Alpha/Beta hydrolase fold [IPR029058] 0.5247119549638396 1.8199274811774189 0.0687700492617076 1.0 0.3484207922805305 27 P50897,Q9HB40,P07099,P42785,Q8NCC3,Q9NUJ1,Q86WA6,P10619 8 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5678957268193727 1.8043057943823344 0.0711833819303158 1.0 0.3563123950664996 20 Q8NB78,Q14534,Q9UHG3,Q96CU9 4 +PX domain superfamily [IPR036871] 0.648405527230551 1.739644527305115 0.0819214554754546 1.0 0.3625147887550818 10 Q9Y5X1 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.9963564094070884 1.7009111707539326 0.0889596686751463 1.0 0.3625147887550818 2 P30519 1 +Ubiquitin-activating enzyme [IPR035985] 0.7275526756901377 1.700058098886973 0.089119997763325 1.0 0.3625147887550818 6 Q9UBE0 1 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.725769803238549 1.692347613683864 0.0905797144251179 1.0 0.3625147887550818 6 Q9NZ08,Q9UIQ6,P09960 3 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.725769803238549 1.692347613683864 0.0905797144251179 1.0 0.3625147887550818 6 Q9NZ08,Q9UIQ6,P09960 3 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.8315008755231978 1.6755637520298008 0.0938236738593416 1.0 0.3645047010107652 4 P42892 1 +Galactose-binding-like domain superfamily [IPR008979] 0.6328668779478737 1.6626488661148209 0.096382743360657 1.0 0.3682511987365341 10 P16278,O43396,P08236,Q9Y375 4 +MFS transporter superfamily [IPR036259] 0.6620065825232028 1.5543381195289552 0.1201037852901674 1.0 0.4107112020944647 8 Q96ES6,Q14728,Q99808,O43826,P53985 5 +PH-like domain superfamily [IPR011993] 0.4462233860659963 1.510564153481963 0.1308995327510815 1.0 0.4336894240085071 48 Q8NC96,P50552,Q9Y217,Q66K14,P50851,Q86X55,Q9NVZ3,P22059,P05067,Q96TA1,Q96AC1,Q96SU4,P32780,Q9Y5P4,Q96P47 15 +Cyclophilin-like domain superfamily [IPR029000] 0.5531514309059261 1.426440946247985 0.1537411015284056 1.0 0.4879543428719087 14 Q6UX04,Q9H2H8,Q13356 3 +Isochorismatase-like superfamily [IPR036380] 0.9108976482278908 1.3618294656280514 0.1732517102032318 1.0 0.5188347652960863 2 Q96AB3 1 +Cytochrome c oxidase, subunit VIIa superfamily [IPR036539] 0.9105664127194448 1.3605173160821844 0.1736662770177723 1.0 0.5188347652960863 2 P14406 1 +DCN1-like, PONY binding domain [IPR042460] 0.8999668764491562 1.3185620529008295 0.1873155670096644 1.0 0.5327479693117273 2 Q96GG9 1 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.7408554385804069 1.3172128978640294 0.187767271769931 1.0 0.5327479693117273 4 Q9BXS5 1 +DNA/RNA polymerase superfamily [IPR043502] 0.7185946304275725 1.2288340488870793 0.2191340326693585 1.0 0.5835473570133333 4 P09884,Q07864,P28340 3 +Ribosomal protein L23/L15e core domain superfamily [IPR012678] 0.7179665122225031 1.226341932682066 0.2200700276847564 1.0 0.5835473570133333 4 P61313 1 +AH/BAR domain superfamily [IPR027267] 0.5126880731519204 1.202176480242657 0.2292951597716053 1.0 0.5975382016874171 14 Q15642,Q9Y5X1,Q9UQB8 3 +Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940] 0.6369016625745769 1.188332727875096 0.2347023485532442 1.0 0.6065604707019342 5 Q13315,O00443 2 +Ribokinase-like [IPR029056] 0.8776576812864444 1.1832644366774987 0.2367043625295937 1.0 0.6069504910852416 3 Q9BRR6 1 +Phosphotransferase/anion transporter [IPR016152] 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.6372421271258063 2 Q9Y6M7 1 +START-like domain superfamily [IPR023393] 0.8588469184890835 1.1159862185277396 0.2644280337867175 1.0 0.643267779453312 3 Q9Y5P4,O95433 2 +NADP-dependent oxidoreductase domain superfamily [IPR036812] 0.6800897154644401 1.076504339871702 0.2817017610207872 1.0 0.654121038302506 4 P48507 1 +Rhomboid-like superfamily [IPR035952] 0.842611000662711 1.0582482001646207 0.2899423018502098 1.0 0.6620450548016513 3 Q9BUN8,Q9GZP9 2 +DUSP-like superfamily [IPR035927] 0.8353214049039126 1.0324469566622918 0.3018627842214285 1.0 0.6843650356225768 3 Q86UV5,Q9Y4E8 2 +Cytochrome P450 superfamily [IPR036396] 0.8261013580655895 1.0295996305404629 0.3031979887749032 1.0 0.6857709227243683 2 Q16850 1 +Ribosomal protein L22/L17 superfamily [IPR036394] 0.8171579993375331 0.99526638859114 0.3196067204636836 1.0 0.7055013638720335 2 Q9NWU5 1 +Bromo adjacent homology (BAH) domain superfamily [IPR043151] 0.5906979132491521 0.9923347469540552 0.3210342586468933 1.0 0.7055013638720335 5 P26358,Q13330,Q9BTC8 3 +Prefoldin [IPR009053] 0.6358717670945349 0.9038552707383368 0.3660721496633341 1.0 0.761525361230233 4 Q99471,O15212 2 +RmlC-like jelly roll fold [IPR014710] 0.4995929955846226 0.900500099321659 0.3678541724826372 1.0 0.7635760853048681 9 O00625,Q9Y4G8 2 +F-actin capping protein, alpha subunit, domain 1 [IPR042489] 0.7853593905266676 0.8749898831754436 0.381579410394762 1.0 0.7693560773611494 2 P47755 1 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.7850281550182248 0.873754056842416 0.3822522053310391 1.0 0.7693560773611494 2 Q15392 1 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.7850281550182248 0.873754056842416 0.3822522053310391 1.0 0.7693560773611494 2 Q15392 1 +Papain-like cysteine peptidase superfamily [IPR038765] 0.4128677239160118 0.8633730963650132 0.3879323664950145 1.0 0.7693560773611494 21 Q96FW1,Q86UV5,Q96K76,P51784,Q93009,O94966,Q9Y4E8 7 +L27 domain superfamily [IPR036892] 0.5189792978068051 0.7870345290190804 0.4312616534689697 1.0 0.8151107049689134 6 Q8NI35,Q14168 2 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.5180654203696244 0.7831452452320826 0.4335418242961326 1.0 0.815228646078414 6 P49366 1 +Dbl homology (DH) domain superfamily [IPR035899] 0.7578668433256087 0.7738682224073508 0.4390087233027411 1.0 0.8222839172799389 2 Q9H8V3 1 +Dynein light chain superfamily [IPR037177] 0.757204372308716 0.771471057957619 0.4404277708767039 1.0 0.8233337861028441 2 P63167 1 +Immunoglobulin-like domain superfamily [IPR036179] 0.4503917582232413 0.7663762773944622 0.4434524439134233 1.0 0.8257687256562581 11 P10586,Q9BY67 2 +Protein-tyrosine phosphatase-like [IPR029021] 0.4501010815548705 0.7649055341650943 0.4443277982513103 1.0 0.825795268455439 11 P10586,Q9Y217 2 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.7545544882411439 0.7619027391594492 0.4461180550565102 1.0 0.8259212640911068 2 P35611 1 +HotDog domain superfamily [IPR029069] 0.5331646169397061 0.7539550003823232 0.4508762429408401 1.0 0.829923832975558 5 O00154 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.5022527604889276 0.7264688149266251 0.4675514183895739 1.0 0.8349754380551236 7 Q01844 1 +Acyl-CoA N-acyltransferase [IPR016181] 0.4423119459151972 0.7022398847180159 0.4825295760374009 1.0 0.8448133760406934 10 O60502 1 +Profilin superfamily [IPR036140] 0.7366677707850333 0.698221034814921 0.4850389736363212 1.0 0.8448133760406934 2 P07737 1 +DNA polymerase family B, thumb domain [IPR042087] 0.7276341948310205 0.6663779743528068 0.5051695372093903 1.0 0.8448133760406934 3 Q07864,P28340 2 +DNA polymerase, palm domain superfamily [IPR023211] 0.7276341948310205 0.6663779743528068 0.5051695372093903 1.0 0.8448133760406934 3 Q07864,P28340 2 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.8448133760406934 3 P52701 1 +MutS, connector domain superfamily [IPR036678] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.8448133760406934 3 P52701 1 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.8448133760406934 3 P52701 1 +Ubiquitin-conjugating enzyme/RWD-like [IPR016135] 0.4284290933244605 0.6350757220793478 0.5253790302373553 1.0 0.8522319775755541 10 Q9NR09,Q9Y3C8,Q16763,P49427,Q99816,P61081,P61086,P61088,Q9C0C9 9 +Kringle-like fold [IPR013806] 0.7161311692613508 0.6272791400245415 0.5304762746803622 1.0 0.8526962968842488 2 Q9UBV2 1 +Fibronectin type II domain superfamily [IPR036943] 0.7161311692613508 0.6272791400245415 0.5304762746803622 1.0 0.8526962968842488 2 Q9UBV2 1 +Translation protein SH3-like domain superfamily [IPR008991] 0.4254925967803184 0.6210316791080011 0.5345787798119697 1.0 0.8526962968842488 10 P46778,P62917,P63241,Q02878 4 +HSP20-like chaperone [IPR008978] 0.4400338852799452 0.6208394602205863 0.5347052571210056 1.0 0.8526962968842488 9 Q8WVJ2,Q9UHD1,Q15185,Q9HB71,O94966 5 +AF1104-like superfamily [IPR036075] 0.7088439880755281 0.6027339213780821 0.5466857115968258 1.0 0.8550806757169744 2 Q9NVE7 1 +Glycosyl hydrolase, all-beta [IPR013780] 0.4482842341594472 0.5769379188428662 0.563981394035201 1.0 0.8550806757169744 8 P10253,P04066 2 +Tautomerase/MIF superfamily [IPR014347] 0.7005631003643656 0.575276865750702 0.565104064848112 1.0 0.8550806757169744 2 P14174 1 +BRO1 domain superfamily [IPR038499] 0.6965882742630076 0.5622695107285408 0.5739324081623507 1.0 0.8550806757169744 2 Q8WUM4 1 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.5399996777351953 0.5511392767421068 0.5815382025972518 1.0 0.8550806757169744 4 Q08380 1 +Cullin homology domain superfamily [IPR036317] 0.4604634256478264 0.5465011638267864 0.5847214879336222 1.0 0.8550806757169744 6 Q13616,Q93034,Q13617 3 +RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792] 0.6829592834900468 0.5281242481412645 0.5974131019437445 1.0 0.8614142306364521 3 Q9Y4E8 1 +PDZ superfamily [IPR036034] 0.3696322815552751 0.5269486071236212 0.5982292780019574 1.0 0.8614142306364521 19 O00560,Q9Y4G8 2 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.6769724442500832 0.5104835152455626 0.609712760643192 1.0 0.8682173112813327 3 P31689 1 +PUA-like superfamily [IPR015947] 0.4145056795951767 0.5074491912949538 0.6118396779069863 1.0 0.8682173112813327 9 O43252,P41214 2 +F-actin-capping protein subunit alpha/beta [IPR037282] 0.6672739129976212 0.4824110615779989 0.6295139647293129 1.0 0.8682173112813327 3 P47755 1 +F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276] 0.6672739129976212 0.4824110615779989 0.6295139647293129 1.0 0.8682173112813327 3 P47755 1 +Ribosomal L18e/L15P superfamily [IPR036227] 0.666132590149018 0.4791499731827136 0.631831940650164 1.0 0.8682173112813327 3 P46776 1 +KA1 domain/Ssp2, C-terminal [IPR028375] 0.6700894335872882 0.4786586358561811 0.6321814970370325 1.0 0.8682173112813327 2 P54646 1 +14-3-3 domain superfamily [IPR036815] 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 0.8682173112813327 5 P62258,P31946,P63104,Q04917 4 +SH3-like domain superfamily [IPR036028] 0.3387128427731694 0.4642869034319785 0.6424422058172388 1.0 0.868973308009495 32 Q9Y5X1 1 +50S ribosomal protein L30e-like [IPR029064] 0.4559018567639218 0.4587730219355272 0.6463971698938837 1.0 0.8694177923257146 5 P55769,P62424,P62888,Q9NX24 4 +Oxysterol-binding protein superfamily [IPR037239] 0.5105420624235573 0.4534930880290335 0.6501937193845961 1.0 0.8714930058715726 4 P22059 1 +Ribosomal protein L2, domain 2 [IPR014722] 0.3739204898460498 0.4000932432296625 0.6890878406656353 1.0 0.8906870056173205 11 P62917,P63241,Q02878,P62701 4 +Moesin tail domain superfamily [IPR008954] 0.6298873426109969 0.380668018434702 0.703449602854402 1.0 0.8931088820587729 3 P35241,P26038 2 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.6292246520874796 0.3789653124724069 0.7047136226066901 1.0 0.8931088820587729 3 Q01968,Q6L8Q7 2 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.3472869208725636 0.3656312958979014 0.7146402190027761 1.0 0.8970985473036138 17 P78417 1 +Ribosomal protein L37ae/L37e [IPR011331] 0.6286849950314768 0.3604632738718229 0.7185007164369595 1.0 0.8971903477383387 2 P61513 1 +Homeobox-like domain superfamily [IPR009057] 0.3354247625664214 0.3569544970654407 0.7211258706880992 1.0 0.8990537627540235 20 Q96G23 1 +Phosphofructokinase superfamily [IPR035966] 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.9185978770231966 3 P17858 1 +GINS, helical bundle-like domain superfamily [IPR036224] 0.6061609804571152 0.3035425206854407 0.7614764481724359 1.0 0.9197939590408984 2 Q9BRX5 1 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.9197939590408984 3 Q9UL46,P61289 2 +Proteasome activator superfamily [IPR036252] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.9197939590408984 3 Q9UL46,P61289 2 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.5941020543406241 0.2943234040415197 0.7685107904181065 1.0 0.9197939590408984 3 Q9UL46,P61289 2 +Nucleic acid-binding, OB-fold [IPR012340] 0.3127909436337135 0.2867381905387156 0.7743127930582865 1.0 0.9197939590408984 40 P27694,Q9Y3B2,P16989,Q9Y2L1,P33992,P62917,Q12904,P35244,P63241,P62266,P15927,O43776,P05198,P62280,P49736,Q14566,Q9Y2V2,Q9NQT5,Q14562 19 +Phosphoribosyltransferase-like [IPR029057] 0.3757877280265242 0.2513581464868533 0.8015372233562721 1.0 0.9346103539386376 6 Q14558,P00492,O60256,P07741,Q06203 5 +Metal-dependent hydrolase, composite domain superfamily [IPR011059] 0.4219423268147076 0.2117758536224031 0.8322819072721237 1.0 0.9513210358450138 4 Q9BPU6,Q14195,Q16555 3 +Metal-dependent hydrolase [IPR032466] 0.4219423268147076 0.2117758536224031 0.8322819072721237 1.0 0.9513210358450138 4 Q9BPU6,Q14195,Q16555 3 +EF-hand domain pair [IPR011992] 0.2924061833292183 0.1651840288492707 0.8687991357106508 1.0 0.9744776270719464 45 Q9BPX6,Q66K14,Q96AY3,Q02818,P80303,P60660 6 +Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056] 0.5322954620735476 0.1588022079834807 0.8738247091689828 1.0 0.9766875245839796 2 P47897 1 +Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035] 0.5322954620735476 0.1588022079834807 0.8738247091689828 1.0 0.9766875245839796 2 P47897 1 +Ricin B-like lectins [IPR035992] 0.5106030483764036 0.1426984325431272 0.8865283546985985 1.0 0.988582200181344 3 Q10471,Q86SF2 2 +RmlC-like cupin domain superfamily [IPR011051] 0.3849313877496187 0.1401722234694215 0.8885239176664954 1.0 0.9896567213033324 4 O00625 1 +Arp2/3 complex subunit 2/4 [IPR034666] 0.4991719112288981 0.1154559794558798 0.9080837103812912 1.0 0.9990743510994384 2 O15144 1 +Ureohydrolase domain superfamily [IPR023696] 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9990743510994384 2 Q13547 1 +Histone deacetylase domain superfamily [IPR037138] 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9990743510994384 2 Q13547 1 +MoaB/Mog-like domain superfamily [IPR036425] 0.4862537263994851 0.1019668654044547 0.9187829755402912 1.0 0.9990743510994384 2 Q8NFF5 1 +Beta-grasp domain superfamily [IPR012675] 0.3154643251003689 0.0976596304142531 0.9222025725286348 1.0 0.9990743510994384 7 P55039 1 +Myosin S1 fragment, N-terminal [IPR008989] 0.3546569439840834 0.095804212184856 0.9236760719112392 1.0 0.9990743510994384 4 P35580,P35579,Q9UM54 3 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.4789665452136601 0.0951496629877462 0.924195951620701 1.0 0.9990743510994384 2 Q9UNN8 1 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.4789665452136601 0.0951496629877462 0.924195951620701 1.0 0.9990743510994384 2 Q9UNN8 1 +TGS-like [IPR012676] 0.309121061359863 0.0927202568823657 0.9261258036701516 1.0 0.9990743510994384 6 P55039,P26639,Q9NTK5,Q9NYK5,Q9Y295 5 +EB1, C-terminal domain superfamily [IPR036133] 0.4756541901291953 0.092232869229562 0.9265130234693066 1.0 0.9990743510994384 2 Q15555 1 +CAP Gly-rich domain superfamily [IPR036859] 0.4746604836038557 0.0913795586404393 0.927191003627216 1.0 0.9990743510994384 2 Q15813 1 +Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001] 0.3020557029177709 0.0737955658886562 0.941173055315116 1.0 1.0 5 P49411,Q05639,Q9Y450,P15170 4 +Cyclin-like superfamily [IPR036915] 0.4393638170974094 0.0704516544375636 0.9438341790524738 1.0 1.0 3 P14635,O95067 2 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.2750300927122618 0.0693090201683028 0.9447436459497168 1.0 1.0 20 Q9NR50,P46976,Q9Y5P6,P15291,Q16739 5 +Dimeric alpha-beta barrel [IPR011008] 0.4264413518886639 0.0622812804466003 0.9503388355724174 1.0 1.0 3 Q9BPW8,Q9UFN0 2 +Pyruvate kinase-like, insert domain superfamily [IPR011037] 0.4206690957270746 0.0583292274595697 0.953486386995508 1.0 1.0 2 Q5VT66 1 +Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825] 0.4166942696257167 0.0567807476662403 0.9547198503286008 1.0 1.0 2 Q8N1G4 1 +Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037] 0.408744617422999 0.0539770220092467 0.956953471327457 1.0 1.0 2 Q10567 1 +p53-like tetramerisation domain superfamily [IPR036674] 0.3945014905598043 0.0498388196655778 0.9602508314869056 1.0 1.0 2 Q13043 1 +Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866] 0.2870120147348675 0.0484372414745456 0.9613677797191972 1.0 1.0 7 Q16775 1 +Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449] 0.3936381709741499 0.0469451571900389 0.9625569375135216 1.0 1.0 3 A0AVT1,Q9UBT2 2 +PABC (PABP) domain [IPR036053] 0.3747514910536738 0.041039602650297 0.9672643240931678 1.0 1.0 3 Q13310,O95071 2 +K homology domain superfamily, prokaryotic type [IPR009019] 0.3315667439549626 0.0409766684043137 0.967314496152282 1.0 1.0 2 P23396 1 +K Homology domain, type 1 superfamily [IPR036612] 0.2599615428137244 0.0390037685532904 0.9688873840306016 1.0 1.0 23 Q9NQT5,Q92945,Q96AE4,Q07666 4 +K homology domain-like, alpha/beta [IPR015946] 0.3316766070245138 0.0332287870259959 0.9734921420661562 1.0 1.0 3 Q8N0V3,P23396 2 +HECT, E3 ligase catalytic domain [IPR035983] 0.2742611962721371 0.0311125989205617 0.9751797420487678 1.0 1.0 7 Q15386 1 +HAD superfamily [IPR023214] 0.260898064887893 0.0239160742959396 0.9809195525162302 1.0 1.0 21 Q9HD20 1 +HAD-like superfamily [IPR036412] 0.260898064887893 0.0239160742959396 0.9809195525162302 1.0 1.0 21 Q9HD20 1 +ADF-H/Gelsolin-like domain superfamily [IPR029006] 0.2637107806213726 0.0216024711063061 0.9827650623349268 1.0 1.0 14 Q14019,Q15436,Q13045,Q6IBS0 4 +Immunoglobulin-like fold [IPR013783] 0.2594881739400504 0.0209945040387884 0.9832500398525308 1.0 1.0 28 P10586,Q8IZA0,P08236,Q9BY67 4 +Longin-like domain superfamily [IPR011012] 0.2615337822881224 0.0208031546948241 0.9834026812020272 1.0 1.0 12 Q92572,Q9BXS5,Q9Y296 3 +NTF2-like domain superfamily [IPR032710] 0.2641008626410138 0.0192937505841938 0.9846067693134531 1.0 1.0 7 Q9UBU9,Q9UN86,Q13283,Q9BRJ2,O43615,P61970 6 +Cullin repeat-like-containing domain superfamily [IPR016159] 0.2561380225613853 0.0111992214176771 0.9910645009237418 1.0 1.0 7 Q13616,Q93034,Q13620,Q9UPT5,Q13618,Q13617 6 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..23068a7650d94150f5e97f3b04c706c7f2bd158d --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP synthase-coupling factor 6 superfamily, mitochondrial [IPR036204]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adaptor protein Cbl, N-terminal domain superfamily [IPR036537]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CBP/p300, atypical RING domain superfamily [IPR038547]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CKK domain superfamily [IPR038209]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Caspase-like domain superfamily [IPR029030]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coactivator CBP, KIX domain superfamily [IPR036529]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily [IPR023471]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Fe-S cluster assembly domain superfamily [IPR034904]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GLE1-like superfamily [IPR038506]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glu-tRNAGln amidotransferase superfamily, subunit C [IPR036113]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "H/ACA ribonucleoprotein complex, subunit Nop10 superfamily [IPR036756]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Helix hairpin bin domain superfamily [IPR029012]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrase-like, N-terminal [IPR017856]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTERF superfamily, mitochondrial/chloroplastic [IPR038538]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Mediator complex, subunit Med7/Med21-like [IPR037212]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "Mir domain superfamily [IPR036300]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily [IPR037073]", "Nuclear receptor coactivator, interlocking [IPR009110]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PCGF Ub-like fold discriminator superfamily [IPR038227]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRC-barrel-like superfamily [IPR011033]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Pre-mRNA-splicing factor Isy1 superfamily [IPR037200]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Receptor L-domain superfamily [IPR036941]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease P/MRP subunit Rpp29 superfamily [IPR036980]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribosome-binding factor A domain superfamily [IPR023799]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rof/RNase P-like [IPR023534]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rubisco LSMT, substrate-binding domain superfamily [IPR036464]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKA1 microtubule binding domain [IPR042031]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scaffold protein Nfu/NifU, N-terminal domain superfamily [IPR036498]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfatase-modifying factor enzyme superfamily [IPR042095]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TAZ domain superfamily [IPR035898]", "TBCC, N-terminal domain superfamily [IPR038397]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Telomere repeat-binding factor, dimerisation domain superfamily [IPR036507]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonine synthase, N-terminal domain superfamily [IPR037158]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transcriptional regulator TACO1-like, domain 3 [IPR026564]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tryptophan synthase beta subunit-like PLP-dependent enzyme [IPR036052]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YebC-like [IPR029072]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "mRNA decapping protein 2, Box A domain superfamily [IPR036189]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALKBH5", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG4B", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5J", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATRX", "ATXN10", "ATXN2", "B4GALT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCKDK", "BCL10", "BCL2L13", "BCOR", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOP1", "BPHL", "BPTF", "BRAT1", "BRD2", "BRD4", "BROX", "BSDC1", "BSG", "BTF3", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACYBP", "CAD", "CADM1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPV", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHP1", "CHRAC1", "CHTF18", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNN3", "CNOT1", "CNOT2", "CNOT9", "CNP", "COA7", "COASY", "COG8", "COL4A3BP", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPZ1", "COQ3", "COQ8A", "CORO1B", "CORO1C", "COTL1", "COX11", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCP1A", "DCP2", "DCTN1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELL", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM129B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HMBS", "HMG20A", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INTS1", "INTS11", "INTS12", "INTS14", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LACTB", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LONP2", "LPCAT1", "LRBA", "LRCH2", "LRIG2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MEPCE", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTCH2", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKIPSD", "NCL", "NCOA5", "NDRG1", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEK9", "NELFE", "NENF", "NEO1", "NFATC2IP", "NFS1", "NFU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIPSNAP3A", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF3", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PICALM", "PIGG", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSME1", "PSME2", "PSME3", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPUSD3", "RREB1", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTKN", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC37A4", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAT1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STUB1", "STX12", "STX3", "STX7", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCP1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFRC", "THNSL1", "THOC1", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMA16", "TMED7", "TMEM14C", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPMT", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTF2", "TTI1", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXN2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBLCP1", "UBP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UGCG", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIPAS39", "VIRMA", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS36", "VPS37B", "VPS37C", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR62", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK2", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H13", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZFYVE26", "ZMYM1", "ZMYND8", "ZNF148", "ZNF281", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2"], "leading_proteins": ["ABHD10", "ACOT7", "ADD1", "ADPGK", "AGAP3", "AHSA1", "AIMP1", "AP1B1", "AP1M1", "AP3S1", "APP", "APRT", "ARPC2", "ATM", "ATP13A1", "B4GALT1", "BAG6", "BAIAP2", "BIRC6", "BPHL", "CACYBP", "CADM1", "CAPZA2", "CARHSP1", "CARM1", "CCNB1", "CCNB2", "CDC34", "CERS2", "CHORDC1", "COL4A3BP", "COTL1", "COX7A2", "CTSA", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CYB5B", "CYP51A1", "DCUN1D1", "DERL1", "DERL2", "DHCR24", "DHPS", "DHX8", "DIS3", "DNAJA1", "DNMT1", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DYNLL1", "ECE1", "ECT2", "EEF1A2", "EIF2B3", "EIF2D", "EIF2S1", "EIF5A", "EPHX1", "ERAP1", "EWSR1", "EXOC7", "EXOSC1", "EXOSC3", "FAM129B", "FERMT2", "FKBP10", "FLAD1", "FLII", "FOXRED1", "FUBP1", "FUCA1", "G3BP1", "G3BP2", "GAA", "GALNT2", "GALNT7", "GBA", "GCLM", "GINS3", "GLB1", "GMPPB", "GSPT1", "GSTO1", "GTF2H1", "GUSB", "GYG1", "HAGH", "HBS1L", "HDAC1", "HMOX2", "HPRT1", "ISOC2", "KDM1B", "KHDRBS1", "KHSRP", "KIAA0319L", "LGALS3BP", "LNPEP", "LRBA", "LRRC47", "LTA4H", "MAPRE2", "MARC1", "MCM2", "MCM5", "MCM6", "MFSD10", "MFSD3", "MGEA5", "MICU1", "MIF", "MPP2", "MRPL22", "MRPL39", "MRPL45", "MSH6", "MSN", "MTA1", "MTA3", "MTCH1", "MTCH2", "MTMR6", "MYH10", "MYH9", "MYL6", "MYO6", "NAGLU", "NARS", "NDUFAF1", "NECAP1", "NECAP2", "NHP2", "NIPSNAP1", "NIPSNAP3A", "NUCB1", "NUCB2", "NUDCD2", "NUTF2", "NXF1", "OCRL", "OLA1", "OSBP", "OSBPL9", "OTUB1", "PABPC4", "PANK4", "PAPSS1", "PATJ", "PCYOX1", "PDCD6IP", "PDE12", "PFDN5", "PFDN6", "PFKL", "PFN1", "PGRMC2", "PIK3C2A", "PIR", "PLA2G15", "POLA1", "POLD1", "POLE", "PPAT", "PPIL2", "PPIL3", "PPT1", "PRCP", "PRKAA2", "PROCR", "PRPSAP1", "PRPSAP2", "PSMA6", "PSMB2", "PSMB3", "PSMB4", "PSME2", "PSME3", "PTGES3", "PTPRF", "QARS", "RAPGEF2", "RBFA", "RDX", "RPA1", "RPA2", "RPA3", "RPL15", "RPL21", "RPL27A", "RPL30", "RPL37A", "RPL6", "RPL7A", "RPL8", "RPS11", "RPS23", "RPS3", "RPS4X", "SAE1", "SCPEP1", "SDCBP", "SEC23A", "SEL1L", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A33", "SLC29A1", "SLC37A4", "SLC4A7", "SNU13", "SNX9", "SQLE", "STK4", "TARS", "TBC1D9B", "TBCE", "TECR", "TIMM44", "TRAPPC4", "TRIP10", "TSG101", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TWF2", "TXNL1", "UBA2", "UBA6", "UBE2K", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBR5", "UFC1", "UGCG", "USP11", "USP15", "USP19", "USP47", "USP48", "USP7", "VASP", "VDAC1", "YBX3", "YWHAB", "YWHAE", "YWHAH", "YWHAZ"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..72c1e8238a25d4eb36d1bf0b2fbb1c20d6a86ffe --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:399f7f4b607d030a37cabb4d980dc4009f5385a4d031495bb19a80e88ab7384c +size 67154 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3dddaf2e8fb26b82cff026bc3c6d04b892b40c3d --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8de2bcf3f2fc97fa631103d71fbd8b1aa20c2e4d --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..911c0f98110fcfc0055bf4e7c9370c039a6363c6 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b3d862c47a5f31b75f18b2c748543308fc3fdefc --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "EIF5A", "FASN", "SLIT2"], "leading_proteins": []} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..709afce78fc2ed51cc088cdfcbbcb2ddcd0b996b --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b381871c3fe050e2284b0f053dfb17e0a803c4b3733aed6cacc3db0734c16218 +size 187288 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8581674daa78a350ab2ba3751bda219c3f411df0 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7721a6eee01076d393ef09fbe368707e3adf3c4494eceb23ae7b48427cb67a37 +size 142661 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5b7b05751379f6234e03e55ddcf0f664a838316b --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fdf3c554f00b68beb389b1287e97aeb29f6c74480cca1bc76e526f7dbd097fca +size 70979 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bd6f07f47e6042b45130194ffa9ef84ded1baaea --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 9 21 2.10722706689928 0.035097901800964 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 1.0 0.0513963234576887 0.0021298798430701 0.0004087345815453 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0c103e2c3f4ada997395ab66b4f381cbab552c49 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 74, + "title": "Average number of proteins per term", + "value": 5.202702702702703 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7c451b200e58cf1c9a00ebb9523e83927951b18a --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..52026a4204b83021284669453e485b8a3c2a6db9 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.6061638159259657 2.10722706689928 0.035097901800964 0.9289178495393694 0.2740636833992643 21 Q9BSK2,Q9UBX3,Q9NZJ7,Q9H2D1,Q9Y6C9,Q9BQT8,Q70HW3,Q9Y619,O43772 9 +HEAT repeat [IPR000357] 0.5998452989920551 1.1394780355299634 0.2545038243572324 0.9999999996361176 0.5707055455283393 6 Q6PJG6,P30153,P30154,Q8TEX9 4 +Leucine rich repeat 4 [IPR025875] 0.7340178867174614 0.6889295487801271 0.4908676033874459 1.0 0.6835814561085025 2 Q13045 1 +Hexapeptide repeat [IPR001451] 0.658127352053123 0.4565373937608263 0.6480035874658305 1.0 0.7734236366527655 3 Q9Y5P6 1 +Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547] 0.5947647448641442 0.2958140047051814 0.7673721271968976 1.0 0.8643128790542343 3 Q8WUH2,Q9P253 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c430d31d24591c69e53f0d79cc75a2f29a0e9b91 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "Furin-like repeat [IPR006212]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "KNL1 MELT repeat [IPR043651]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AGAP3", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ARVCF", "ASPH", "BCOR", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CDC16", "CDC23", "CDC27", "CDC40", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN3", "COA7", "COPA", "COPB2", "CORO1B", "CORO1C", "CRNKL1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DSP", "EDC4", "EED", "EHMT1", "EHMT2", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EML4", "EPPK1", "ERBIN", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GMPPB", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HIRA", "HTT", "HUWE1", "IFIT5", "IGF1R", "IGF2R", "ILK", "INTS4", "IPO4", "IPO5", "JUP", "KAT7", "KDELC1", "KDELC2", "KDM2A", "KIDINS220", "KLC1", "KNL1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRCH2", "LRIG2", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MRPS27", "MTCH1", "MTCH2", "NAA15", "NASP", "NEK9", "NHLRC2", "NIPBL", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUP214", "NUP43", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PEX5", "PHIP", "PIK3R4", "PKP2", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP4R1", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP5", "RCC1", "RCC2", "RPAP3", "RSU1", "SART3", "SCML2", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHCBP1", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STUB1", "SUGT1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TEX10", "TGFBRAP1", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TPBG", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", 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0000000000000000000000000000000000000000..89796040e668fecdca63a40f40cb36cc274ed388 --- /dev/null +++ b/msigdb_gobp/df_merge.tsv @@ -0,0 +1,147 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Anion transport 23 63 3.648760934054199 0.0002635081729034 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 0.206194193840509 0.2424540817316537 0.012510098203701 0.0003718061622029 1.3898754363978491e-05 +Lipid localization 17 63 3.638568067877941 0.0002741581703469 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.0136899199067385 0.0036684023597506 0.0012667041047781 7.113996302245242e-06 0.0026614616007854 +Anion transmembrane transport 15 43 2.985778945850043 0.0028285703083237 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.0807340326369145 0.0974060227674832 0.0044166793623189 0.0003886147726859 2.812293441458397e-05 +Cell recognition 5 23 2.9228083340255027 0.0034688997621861 5.29126213592233 22.859223300970875 0.9056944851933356 0.3618031966115522 2.859598274322472 2.538937048941188 0.9847101891513528 0.3060121099700091 0.0271700598866728 0.0333019544595367 0.0207328276809773 0.0035372417514602 0.0092276396306031 +Sphingolipid metabolic process 13 27 2.871892763030835 0.0040802139958167 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 0.0071738165736294 0.0097273770857752 0.0002783591093982 1.6415388153324415e-05 4.557155110007454e-05 +Inorganic anion transport 9 24 2.7640195588194527 0.0057094116891807 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.0341033930185741 0.0416950911647941 0.0285769937968429 0.0002540391317245 0.0004696858209301 +Membrane lipid metabolic process 16 36 2.7568481036948835 0.0058361455399413 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 0.0139355050062102 0.0023813804946987 0.0001498589333904 3.383899756310029e-05 1.9390166381822235e-05 +Regulation of stress activated protein kinase signaling cascade 13 26 2.6464035973310227 0.0081352689459595 6.951456310679611 27.381067961165048 0.2313650341297954 0.6911021636242265 4.675651952415842 3.759509731675893 0.7215171740138203 0.3097912587256555 1.0 1.0 0.317502679856318 0.1640234719188354 0.0307820491245205 +Organophosphate ester transport 11 29 2.6193034276717717 0.00881095369058 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0436242991075366 0.0531691841805127 0.0009512079801521 1.994495517635176e-05 2.436728238140036e-05 +Phospholipid transport 6 14 2.5705898231032696 0.0101525494750107 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0194375447241864 0.0238997911322505 0.0128487417044244 0.0002149097959721 0.0007141638201065 +Protein transmembrane transport 5 23 2.551094071609833 0.0107385336433865 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0014132660261148 0.0019447965050573 0.0016384890204764 0.0017183337360303 0.0433996585313532 +Phosphatidylcholine metabolic process 3 13 2.5477968750421427 0.0108405571138421 3.75 12.592233009708735 0.9144963280277142 0.2812959412325629 1.879404212556404 2.4412987678409657 1.1545250012369797 0.2602001877022786 0.0005744502579039 0.0007945346802546 0.0061250241039257 0.0144174128758978 0.120966113106861 +Negative regulation of calcium ion transmembrane transport 1 6 2.5333355312191874 0.0112982746608938 2.1067961165048543 7.601941747572815 0.9433101814663925 0.3101119054926485 1.594362771690279 1.170758660555987 1.028728108691548 0.2750664841729511 0.0772251634861832 0.0858288536093336 0.014058804472369 0.0768284795296569 0.2369865842622187 +Regulation of blood pressure 5 17 2.5229756689552607 0.0116366452152159 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0018344506398269 0.0025198212347625 0.0002266749410996 0.0027389701542927 0.0626099192975905 +Lytic vacuole organization 7 19 2.504321047408207 0.0122686651430206 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 0.224551409798482 0.2471994937249445 0.1132051672598368 9.383361651678993e-05 0.0005873508489337 +Transition metal ion transport 2 10 2.4904289363462717 0.0127589008162583 4.70873786407767 14.08980582524272 0.8861898222657586 0.2678437025860737 2.4756329698054333 2.718007722894407 1.3738160036140448 0.271065502827487 1.0 1.0 0.4353012614103685 0.1728856135395864 0.5555158130103539 +Transition metal ion homeostasis 4 19 2.477564690812315 0.0132282426176797 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 0.0446254269650129 0.0543724481878489 0.1793408912067547 0.1301968517658698 0.352469032819341 +Neutral lipid biosynthetic process 1 6 2.4729321507973228 0.0134009582425906 2.1067961165048543 6.288834951456311 1.1186547336258812 0.1821371148552785 1.2515048910859687 1.3298556757746482 1.2887117600293918 0.213034599641239 0.0057036049754646 0.0070670490819082 0.0274603336438859 0.1392702662277763 0.3827254031641982 +Lipid homeostasis 9 22 2.459748126739062 0.0139034552556431 7.665048543689321 25.939320388349515 0.8425417577103904 0.3366972259521467 2.992619034719237 3.7336969269092393 1.1648658675422845 0.295769208633365 0.2968609783252757 0.058039929090825 0.0011889754911147 0.0039935546580918 0.0069719244140722 +Negative regulation of calcium ion transport 1 8 2.4487155618781498 0.0143366614309816 2.378640776699029 8.815533980582524 0.865801675063994 0.3348216966365627 1.767376998119782 1.5264501163101216 0.996781239251156 0.2731835761958332 0.1192388354082917 0.1321770275159086 0.0334071197556988 0.1648346062433529 0.4346340509927128 +Protein insertion into membrane 4 23 2.4478283273545745 0.0143720115020229 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 0.1943215284903705 0.2143583684675494 0.0014189260290535 0.007721883439699 0.0369035419304253 +Glycerolipid biosynthetic process 11 41 2.4439182549811145 0.014528718045367 13.466019417475728 44.71844660194175 0.9430872689732808 0.3767257192898063 6.88753698417372 8.249645447783736 1.3199493331746477 0.3584243730449019 0.0069111448363323 0.0101766101005315 0.0965212586027388 0.1524051912460338 0.1055140624314031 +Pigment metabolic process 2 25 2.420912525020789 0.0154816022067489 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0015734849900554 0.0021637050259114 0.0157478410048603 0.0443488880214379 0.2808769591781639 +Leukocyte apoptotic process 1 15 2.4131159063254786 0.0158167888329059 4.094660194174757 20.116504854368937 0.319607386113788 0.5151581496278227 2.552035287340865 3.1105862803108337 0.939636459151083 0.2990440433897824 0.0288434566891126 0.0353307530420815 0.1226746045160812 0.4556449680966442 0.8202778956166314 +Establishment of protein localization to membrane 15 76 2.39344711568475 0.0166908873093565 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 0.581414427520013 0.249454442152862 0.0034462087166857 0.0111383980714153 0.0219683780231214 +Mitochondrial transmembrane transport 12 54 2.3792816488051787 0.0173464164697738 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 0.005426540837187 0.0006619831437869 1.6342529313586228e-05 3.812521632033891e-05 0.0002252023491574 +Neuromuscular process 9 27 2.373789801802089 0.0176065703673968 6.682038834951456 25.487864077669904 0.5107907507501308 0.3958015985368521 2.5973040014911133 3.0533044809467955 1.2106508695866462 0.3144907539964949 1.0 1.0 0.1323300889211223 0.0001857911938182 0.0003156996925404 +Intracellular protein transmembrane transport 4 20 2.3669285847422388 0.0179363934749929 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0153347588201295 0.018891152845815 0.0091243340822671 0.0045172618985585 0.066946879618907 +Protein lipid complex subunit organization 1 5 2.366825395889485 0.0179413948663094 1.1310679611650485 5.281553398058253 0.8340606377827192 0.3186795511043827 1.091585568626531 0.8580569122292387 0.9998971723912514 0.2555622550899711 0.0028386769140382 0.0035263772514821 0.014058804472369 0.0768284795296569 0.2369865842622187 +Inflammatory response 21 60 2.3615819133811837 0.018197151310582 13.228155339805824 68.3883495145631 0.4116983048649594 0.5194837377797665 5.6022172704029956 8.769134982645609 1.0984550499812151 0.3566163019943059 0.3299038019802844 0.3797064675037163 0.2804956905008622 0.2393874199350416 0.2890085840315519 +Neuron projection guidance 10 24 2.352549319625921 0.0186452169852784 5.662621359223301 23.189320388349515 0.4437647002001748 0.5678522712486597 2.931294310088859 4.519975354803488 0.8912373776728286 0.311775964869191 0.4345043850978324 0.4708564934485306 0.3700525131557232 0.2274335351905349 0.2081348839731603 +Regeneration 4 29 2.345542889923906 0.0189993925099589 6.191747572815534 31.563106796116504 0.5380382799076718 0.5740012495882397 3.277553825936591 3.489707203654107 0.7812061797301654 0.3285807753592402 0.0722204468338396 0.087320023469893 0.0801526286479979 0.0427349298488789 0.2527645926964074 +Regulation of monooxygenase activity 2 9 2.338186311789136 0.0193775852769528 2.8932038834951457 9.66019417475728 0.7817888300341583 0.3389498053111844 1.538582258508953 1.1621322724229128 0.9599177691687591 0.2497120029370768 0.0057036049754646 0.0070670490819082 0.0274603336438859 0.0270423729706739 0.009006759688013 +Regulation of nitric oxide synthase activity 1 6 2.3338238856634046 0.0196049455586311 1.8980582524271843 6.400485436893204 0.8861714382596724 0.3064882013314778 1.014121704509923 0.9815283096291466 0.998778670456744 0.2492245557560045 0.0028386769140382 0.0035263772514821 0.014058804472369 0.0768284795296569 0.0627230635966129 +Vitamin transmembrane transport 2 6 2.3085439303928417 0.020968902395718 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0614672516091427 0.0683810764565047 0.0088504827764808 0.005208827916976 0.004988841333209 +Vitamin transport 2 6 2.3085439303928417 0.020968902395718 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0965594926942356 0.1071891284628969 0.0219975904219434 0.0197332243190265 0.0274602362801676 +Protein import into mitochondrial matrix 2 9 2.3054242143638826 0.0211428266536681 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.001761795183682 0.0021914548918381 0.0088504827764808 0.005208827916976 0.0339846578092061 +Axon development 14 76 2.2997225140700985 0.0214639457696521 15.014563106796116 75.88349514563107 0.4221802741874887 0.6742105443551618 6.65661081388802 8.797672872875632 0.8036898770047755 0.340363217999487 0.3516096859852021 0.4032284169243677 0.151199283707238 0.1772119868320016 0.2653477960234573 +Leukocyte mediated cytotoxicity 2 14 2.295333410828456 0.0217140242837172 4.351941747572815 13.985436893203884 0.4021439577883799 0.5004679143122512 2.4135380942775657 1.8380502421368885 0.9762325275008988 0.3133102965191064 0.1770329207061845 0.1955113655682517 0.0720571885403784 0.100752004546059 0.1856866108969999 +Mitochondrial transport 13 76 2.2933333066919195 0.0218288230921108 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 0.0054346078268654 0.0011348652495957 0.0002139788138078 6.286150926410408e-05 0.0036786287352893 +Aminoglycan catabolic process 4 5 2.288720818790478 0.0220955786106407 2.6893203883495147 4.728155339805825 0.5164809724591738 0.1764823388548578 1.1619294817897845 0.7656988020633148 1.69808407883546 0.2279588459746903 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.0001450038876457 0.0001620848202149 +Glycosaminoglycan catabolic process 4 5 2.288720818790478 0.0220955786106407 2.6432038834951457 4.665048543689321 0.5167433573606753 0.1777854895826483 1.1305026922003756 0.6751064263980151 1.6910244329591049 0.2288538535307848 0.0454466093947272 0.0506073598520519 0.1008375048293403 9.854683287521486e-05 9.8492817269125e-05 +Positive regulation of oxidoreductase activity 2 8 2.286499177300986 0.0222250722000987 2.179611650485437 8.660194174757281 0.9323097289205834 0.3351781724420858 1.467039765796201 1.084340415669104 0.8660275673035036 0.2662046996688798 0.0089475442467942 0.0110614955842043 0.0420348553288257 0.0489147892655661 0.0821355875685036 +Protein targeting 20 100 2.2851107831723354 0.0223063326833869 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 0.0208725254902399 0.0299401836570304 0.0006716226852438 0.0004134455197126 0.0012521149425258 +Regulation of jnk cascade 7 12 2.2758910468904143 0.0228525314914855 3.745145631067961 12.730582524271844 0.0342722637181126 0.5856074037040684 2.335999552831812 2.800439745372428 0.865405433051665 0.3027772361459041 1.0 1.0 0.552858073626208 0.3284623958158804 0.218869806801983 +Cell cell recognition 1 13 2.2743083133442945 0.0229474556773652 3.0024271844660193 13.21359223300971 0.2975896784004073 0.5899504458400457 3.268337948212673 0.8966007590364411 0.7692763436039676 0.2944005804236999 0.0965594926942356 0.1071891284628969 0.0219975904219434 0.1147066696002357 0.1098061730973064 +Sperm egg recognition 1 12 2.271702137397257 0.023104507011477 2.516990291262136 11.101941747572816 0.2976828055471704 0.5549281700618328 2.928302246771912 0.4507772322461607 0.804421007566121 0.2870759373714208 0.0654311950523822 0.0727733471903131 0.0100519320580488 0.0565188023636715 0.0403506671570748 +Binding of sperm to zona pellucida 1 12 2.271702137397257 0.023104507011477 2.516990291262136 11.101941747572816 0.2976828055471704 0.5549281700618328 2.928302246771912 0.4507772322461607 0.804421007566121 0.2870759373714208 0.0574868878492186 0.0639684350193291 0.0077184558590264 0.0442367692127036 0.0281854945142632 +Positive regulation of monooxygenase activity 2 5 2.259928471897548 0.0238256905063782 1.6844660194174756 5.415048543689321 1.0370130759472405 0.2898065983925483 1.0180179945339054 0.878583782950111 0.884976405150879 0.2417237008540366 0.001761795183682 0.0021914548918381 0.0088504827764808 0.005208827916976 0.004988841333209 +Purine ribonucleoside salvage 0 5 2.2574154579772863 0.0239821267097777 1.194174757281553 5.087378640776699 0.7525597745497481 0.4015392353821809 1.3351720912111715 0.2990858602087254 0.9698061350109142 0.3038187137036782 0.0250448237277202 0.0279227766388577 0.0563150378970086 0.1373795195898598 0.2595746201812825 +Nucleoside salvage 0 5 2.2574154579772863 0.0239821267097777 1.194174757281553 5.087378640776699 0.7525597745497481 0.4015392353821809 1.3351720912111715 0.2990858602087254 0.9698061350109142 0.3038187137036782 0.0332561421167613 0.0370595951599339 0.0743799864466655 0.1788587842302525 0.3301808657155594 +Purine nucleoside biosynthetic process 0 5 2.2574154579772863 0.0239821267097777 1.4611650485436891 5.742718446601942 0.8935109670252933 0.3592786141720023 1.2698698816998135 0.508968486969168 1.0201063575252725 0.3098922359465458 0.0413998977907473 0.0461123069087121 0.0921025797166938 0.2183511668733661 0.3940663935801297 +Regulation of oxidoreductase activity 2 15 2.255859558510604 0.0240794279495528 4.745145631067961 16.524271844660195 0.8435277245089666 0.3527293456818395 2.542951562396442 1.641953963820047 1.0033906386071183 0.2899852749738094 0.0216431235145122 0.0265864003984115 0.0949012099695084 0.1435696883620607 0.1224012932705566 +Iron ion homeostasis 1 14 2.248751001530957 0.0245283423529421 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0194375447241864 0.0238997911322505 0.08610744549237 0.3532043826100663 0.4573123863891611 +Glycoside metabolic process 4 9 2.2435939262013824 0.0248585404150352 3.283980582524272 8.611650485436893 0.5062828222010527 0.3204164092287125 1.4990079825210394 0.6824144700308834 1.298018080705215 0.2868097664691992 1.0 1.0 0.1349531130589082 0.005208827916976 0.000543833852376 +Negative regulation of transport 12 65 2.242624851007806 0.0249210163316622 15.611650485436892 75.64320388349515 0.3645955382320408 0.672265905834044 6.305311383653456 9.610692741829228 0.7092161069595118 0.3277694528833091 0.2608767881158667 0.3037962454943535 0.1898130826550857 0.3470189493865518 0.259025136789845 +Intracellular lipid transport 3 9 2.236051732086389 0.0253483826796345 3.2475728155339807 12.529126213592232 1.0333463606041455 0.2805251274605093 1.854375285913986 2.478377603832177 1.0146678848168829 0.2521579143644115 1.0 0.1444128696349771 0.0038117145357013 0.0080316637526189 0.0208457080812305 +Triglyceride metabolic process 1 10 2.2352257575864933 0.0254025312928762 3.4805825242718447 10.771844660194176 0.9779567044833 0.270555786798488 1.9834538010888536 2.3392770219831345 1.099054194056709 0.249087443977639 0.1908924307713893 0.2106238865638343 0.3837329617110586 0.344328227558065 0.7090070314070043 +Natural killer cell mediated immunity 2 9 2.230060961857165 0.0257433960261901 3.0266990291262137 9.79611650485437 0.3581391067116419 0.5074304089326694 1.9300298746867943 1.587935236879548 0.9456543485669218 0.3100992296137194 0.1229642662659278 0.1362745587685063 0.0354914601129098 0.0387286577629364 0.0623633603808868 +Tetrahydrofolate biosynthetic process 0 5 2.2297858733265663 0.0257616616791898 1.7936893203883495 4.983009708737864 0.1605580267226933 0.4510199931505445 1.7386689978430927 0.1292347525434382 1.0823232133771 0.2967084841927126 0.0250448237277202 0.0279227766388577 0.0563150378970086 0.1373795195898598 0.2595746201812825 +Folic acid containing compound biosynthetic process 0 5 2.2297858733265663 0.0257616616791898 2.0364077669902914 5.548543689320389 0.1185786473734218 0.460967837187085 1.9007241105446349 0.5306826667147115 1.0747056928647158 0.3004314837246528 0.0332561421167613 0.0370595951599339 0.0743799864466655 0.1788587842302525 0.3301808657155594 +Positive regulation of pattern recognition receptor signaling pathway 3 9 2.2283136325467465 0.0258596078905579 2.2111650485436893 8.881067961165048 0.9294615798342404 0.3761478315320766 1.5785490455680595 1.1095047549274055 0.7380925067462184 0.2772941348424764 1.0 1.0 1.0 0.0197332243190265 0.0274602362801676 +Sterol homeostasis 1 8 2.224460742338925 0.0261174609767913 3.2597087378640777 11.594660194174756 0.7425754872590924 0.2773502445350785 1.6018884221780605 1.6170423171351411 1.3033948892752858 0.2615762483252933 0.1486147431852646 0.0136970422924113 0.0513963234576887 0.2359805031570881 0.2832795756669947 +Negative regulation of stress activated protein kinase signaling cascade 5 9 2.224333013762857 0.0261260470837538 3.83495145631068 9.41019417475728 -0.0607437870152996 0.5896640946176641 2.283741978601781 1.2204539029748132 0.8395438390397254 0.2953024296785091 1.0 1.0 0.2802926639431586 0.5676800659750835 0.0234894970885714 +Regulation of endothelial cell migration 4 24 2.2217131700088486 0.0263026959401992 5.495145631067961 27.978155339805824 0.5955926179251096 0.4502618340992453 2.841693008322481 3.167187428757454 1.0132828172462562 0.3207559953771818 0.0092199681595976 0.0124618639443786 0.0766374872717975 0.1060195586833045 0.3895255812818475 +Response to reactive oxygen species 2 31 2.2180835555719303 0.026549135837353 6.643203883495145 34.40291262135922 0.3370560023195971 0.5582061055009889 4.209487369013932 4.78801003135187 0.9361306406896482 0.3200560676091487 0.0186814577262946 0.0249752776964441 0.1382318498722026 0.6371884239133168 0.7901154801464116 +Protein transmembrane import into intracellular organelle 3 14 2.2166558679781927 0.0266466167028784 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0070122547776667 0.0086801325315587 0.0334071197556988 0.0056932223374956 0.0564014374232863 +Regulation of response to reactive oxygen species 0 7 2.2050872176853726 0.027447974869172 2.179611650485437 7.944174757281553 -0.0623480553155879 0.4810439073108864 1.7381420290822969 1.2692364681879964 0.9814591255351324 0.2740586473575921 0.0965594926942356 0.1071891284628969 0.2070995190727305 0.4465871194719102 0.6997715576731252 +Sarcoplasmic reticulum calcium ion transport 1 6 2.204930367719726 0.0274589811542349 1.9563106796116505 7.322815533980583 0.6468881172758483 0.4186906915304785 1.3230715882937036 1.363591714565082 0.9330202288701288 0.2915813242092217 1.0 1.0 0.0126574737404708 0.0698282842903305 0.2186430557746356 +Ceramide transport 3 6 2.2022408232582107 0.0276483018129238 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 1.0 1.0 0.1180585699575878 0.0002054625318554 0.0002528551610256 +Phenol containing compound metabolic process 1 10 2.2009066352111724 0.0277426341144837 3.2014563106796117 11.03640776699029 -0.2758593249178785 0.5030165882525587 2.155529762905364 1.5426413827159666 0.9331170228768186 0.291923054465156 0.1700164788689393 0.1878492321971458 0.3467918934582977 0.2903927816552063 0.6406568642020245 +Cellular response to camp 1 5 2.1963320928814745 0.0280681822627939 1.6019417475728157 5.065533980582524 -0.1953998899771133 0.4214681310513395 1.2034723695122669 0.805368188314036 1.1508648793217675 0.2996934524264009 0.1041819332558558 0.1155957163384056 0.2223047329091382 0.1309570889500886 0.3649620055651655 +Skeletal muscle contraction 1 5 2.195798700872189 0.0281063546997648 1.3325242718446602 4.036407766990291 0.2151702392185859 0.4949936055010072 1.1631938108689743 0.9735006937421118 0.9803634833264944 0.2996383957272171 1.0 1.0 0.1094892401774078 0.0331187861076589 0.1137231346556503 +Regulation of transmembrane transport 12 60 2.189972704992258 0.0285262164164881 15.57766990291262 71.15776699029126 0.1836301063318308 0.6755370701476794 5.89110621485687 8.420205867930298 0.7166360905555917 0.3069957102248473 0.6226186290129978 0.6631385801607901 0.375786201091113 0.1045213172312255 0.2248880640130311 +Glycerophospholipid catabolic process 1 8 2.1889824733158703 0.0285981139297424 2.216019417475728 7.563106796116505 0.8419758607208171 0.2558936783676348 1.405411068501889 1.391164232085279 1.2384126210044872 0.2497846504551273 0.0020080999837554 0.0024970154667983 0.0100519320580488 0.0565188023636715 0.0403506671570748 +Aminoglycan metabolic process 7 15 2.184172837415984 0.0289495500760195 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 0.2311171554709545 0.2543128795765555 0.4515227909961177 0.0038382700604267 0.0101560616848899 +Plasma membrane organization 8 26 2.162728484825796 0.0305620688902286 7.099514563106796 28.24514563106796 0.6737258386983643 0.4958528160030953 3.5234718862626195 4.368421626063976 0.8695791931528731 0.3271220115282837 0.290844094699813 0.3186897272236745 0.0428883183388871 0.0007608631417027 0.0168825081458745 +Positive regulation of cation channel activity 2 7 2.162556526226876 0.0305753050318857 2.4684466019417477 7.276699029126213 0.0438926340617352 0.528833901866312 1.6769350551489708 1.3710391412692278 0.9471475366324456 0.3019789925380542 1.0 1.0 0.2445730022705269 0.1562190614045352 0.1665994534041104 +Regulation of ion transmembrane transport 12 53 2.159246572657276 0.0308310426552627 12.769417475728156 58.17718446601942 0.1848604344463112 0.6511851783870115 5.216919510135131 6.419415621934549 0.7476579878822972 0.307649164549728 0.531816297206107 0.5714502484543804 0.2445662454721797 0.029814348284621 0.095803634609447 +Protein targeting to membrane 9 31 2.1564323136461643 0.0310499237421086 9.03640776699029 34.86407766990291 0.8678999397376299 0.4369909067843477 3.776027437978551 4.807050937156168 0.9685770296783628 0.3476738150633759 1.0 1.0 0.0570724957906687 0.0233302597099157 0.0046461548698049 +Glycoside catabolic process 4 6 2.1506864489835578 0.0315009566634327 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 1.0 1.0 0.0743799864466655 0.0007272762906085 1.349938957136589e-05 +T cell apoptotic process 0 7 2.149223797201473 0.0316166637417973 2.145631067961165 10.701456310679612 0.7461760702030203 0.3927793123326719 1.654107960636956 1.7995948345334825 0.9259723405034824 0.2877845742037807 0.1079695612646594 0.1197698958477507 0.2297987482657219 0.4860897569734319 0.7417475603012252 +Cellular hormone metabolic process 6 16 2.1458843243046424 0.0318822087535235 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.1943215284903705 0.2143583684675494 0.3896854720293997 0.034999603504981 0.0114047225139018 +Organic cation transport 2 5 2.1432095737118195 0.0320962738869736 2.191747572815534 5.524271844660194 1.626219676916526 0.1372808582950073 1.481153399412497 1.209546654977186 0.871004228766265 0.1892257790071234 1.0 1.0 0.1837383274168749 0.0914454637274335 0.0801939864225387 +Purine containing compound salvage 0 6 2.1346599089045712 0.0327888000232956 1.8737864077669903 7.233009708737864 0.7743343410521683 0.3736672462346809 1.748395167894324 0.8238423298008908 1.0837559690437977 0.3116170205148165 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.2559514735144251 0.451869757084416 +Blood vessel endothelial cell migration 3 20 2.126741259084403 0.0334415873565208 4.536407766990291 22.449029126213592 0.7681724367497832 0.3963490094539818 2.4704338498615206 2.406468634828595 1.0319905271466427 0.3120666413936225 0.0031421406678005 0.0042974194252635 0.029653655190088 0.0904947271532713 0.1260437200975292 +Cytosolic calcium ion transport 3 23 2.1231282617781035 0.0337431053447736 6.567961165048544 23.944174757281555 0.4634706877593821 0.4616211122842976 3.323605294530572 2.8902732844456565 1.0331628024603872 0.3216839736311487 0.3028279886490784 0.3315322885250054 0.0483217377147592 0.152340992243069 0.6018900187848713 +Ceramide metabolic process 8 18 2.119394350736702 0.0340571538394389 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 0.2145999915509279 0.236404668572991 0.0173242512102645 0.0025056010914147 0.0016290145146394 +Calcium ion import 2 14 2.1179662100047976 0.0341779294744737 4.516990291262136 12.686893203883496 1.0417029373125424 0.2391249176108038 2.3196506830054986 1.9148178088324157 1.3383409214307818 0.27915846054651 0.1449957667029796 0.1604648724397155 0.0052800410185589 0.0602711275874904 0.2698089294696847 +Neuron projection regeneration 2 11 2.1082208386181627 0.0350118915763795 2.3058252427184467 9.79611650485437 0.887202443720293 0.3987106095324453 1.3505356896696743 1.5461145996848544 0.8042022398095918 0.2932545495700766 0.1377126811078632 0.1524760813950871 0.0443091130960601 0.0525727870350727 0.2431148013647541 +Neuron migration 2 27 2.107417299997263 0.0350814233189107 6.468446601941747 23.691747572815533 -0.3904795271907602 0.5630056174351626 3.2859622749495108 3.435908304659496 0.8402411534291746 0.3090181374266468 0.0087388663131837 0.011820001819681 0.0731929968318565 0.2311533630783868 0.5526582721292626 +Regulation of membrane lipid distribution 4 7 2.107349271242315 0.0350873153865267 2.2475728155339807 5.5 0.9490281853542848 0.2470521989607894 1.5110816970578842 2.070950253254846 1.235309366119274 0.2447223644308076 1.0 1.0 0.2297987482657219 0.0004258249435971 0.009006759688013 +Circulatory system process 10 68 2.1059990123537693 0.0352044381401441 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.0815041572971108 0.1050127227394533 0.008632132186118 0.0343575425967005 0.083947483300893 +Glucosamine containing compound metabolic process 1 5 2.100343477645463 0.0356986372566354 1.0631067961165048 4.043689320388349 0.3888966696826618 0.521842041001074 1.1970424955561958 1.0465078221995192 0.9423128491171514 0.3121597137993275 1.0 1.0 0.1432798584585485 0.0565188023636715 0.1824124195300006 +Organic acid transmembrane transport 9 29 2.0896653858691847 0.0366478684507318 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 1.0 1.0 0.1793408912067547 0.0450659748291681 0.0053731990090933 +Positive regulation of inflammatory response 1 10 2.086749674945993 0.0369107683756759 3.71116504854369 12.604368932038836 -0.2371758915201458 0.5181114568213592 2.0280967216986476 2.002736075028172 0.9629686677278052 0.3077182349956747 1.0 1.0 0.3777229935777695 0.3354134477865137 0.6984217718540238 +Protein targeting to mitochondrion 8 41 2.076552646376925 0.0378428673002255 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 0.0059765039357199 0.008121261283644 0.0015449109291633 0.0013144682510841 0.0035818354208013 +Vesicle transport along microtubule 4 11 2.074391378198439 0.0380429773976624 4.514563106796117 11.58980582524272 -0.102125747194735 0.5711972684164484 2.4921783572738394 1.5404554115317726 0.8762002857901487 0.2964402233799867 1.0 1.0 1.0 0.6179297811879729 0.120966113106861 +Negative regulation of protein polymerization 11 24 2.067308912540785 0.0387050549785925 6.514563106796117 25.76456310679612 0.3577422649109862 0.6236942072656753 4.320562885096777 2.176754186789784 0.8134255649148494 0.326257475817155 0.0280016517596001 0.0343104139968933 0.1194965359594502 0.447448107055433 0.1847572156688234 +Lipoprotein catabolic process 3 5 2.0660173168303944 0.0388268445069672 1.529126213592233 5.211165048543689 0.7074087979902727 0.279320898549559 1.1111204061152251 0.9407555329409328 1.2623530327786678 0.2599848817817885 1.0 1.0 0.0088504827764808 0.050241067872642 0.004988841333209 +Central nervous system neuron differentiation 6 16 2.063880615049503 0.0390290371350789 3.7645631067961167 16.932038834951456 -0.0525887127304744 0.597954206262858 2.8353535341281972 2.872744825675142 0.8162287944142489 0.2953166164243903 0.3488164050891373 0.3805737292783386 0.2533609509960167 0.4470347519884879 0.7337991673264309 +Peptide catabolic process 3 10 2.058431086685117 0.0395487701730987 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 1.0 1.0 0.014058804472369 0.0009927961558234 0.0017902696143218 +Negative regulation of proteasomal protein catabolic process 7 21 2.057619133107083 0.0396267085308001 5.640776699029126 21.189320388349515 -0.0165502410140291 0.6606879359480108 3.3366292185931727 2.2507997552265735 0.7665554170772628 0.2921426084583799 1.0 1.0 0.327507803675052 0.0771340965144245 0.0480087672890962 +Tetrapyrrole metabolic process 1 18 2.053588278623528 0.0400155575708052 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.0146921641380013 0.0181053013145446 0.0666692325567911 0.0909853548684221 0.3646272656082709 +Fatty acid transmembrane transport 1 5 2.053565519032483 0.0400177623034425 2.3519417475728157 6.720873786407767 1.487456141723218 0.1763040127694548 1.5547987465385102 1.1092073674791965 0.7935702169981724 0.2103298472796338 1.0 1.0 0.1094892401774078 0.0331187861076589 0.1137231346556503 +Sterol metabolic process 10 34 2.053416352676555 0.0400322146718448 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 0.3028279886490784 0.0605318649589048 0.0089732445190698 3.812521632033891e-05 0.0027222229885513 +Nucleobase containing small molecule biosynthetic process 0 6 2.049247892388763 0.0404378811106105 1.7135922330097086 6.725728155339806 0.7645590390237343 0.3868941709719335 1.5487262880443011 0.5167281344531495 1.0510813905138674 0.3156372982117756 0.0534900373740109 0.0595353304203936 0.1180585699575878 0.2740704871267072 0.4786734551421467 +Glycosyl compound biosynthetic process 0 6 2.049247892388763 0.0404378811106105 1.7621359223300972 6.927184466019417 0.7674599123201137 0.3848892158216302 1.5816678247150102 0.68587612099484 1.0539983320068638 0.3161304697180149 0.0693787843053731 0.0771453392642774 0.1515272625734178 0.3422564852890665 0.5734281396877692 +Microvillus assembly 0 6 2.047483936353104 0.0406105924971162 2.0024271844660193 5.398058252427185 -0.487897024331676 0.4405691056004866 1.389102501351504 1.2254565689700707 1.0171086814511006 0.307614349725875 0.0772251634861832 0.0858288536093336 0.1677870330809631 0.373917962138579 0.6141484764039431 +Chemokine production 2 8 2.047370630122828 0.0406217078085329 1.8810679611650485 8.337378640776699 0.9152793985046536 0.327029475914965 1.2820382835273771 1.4780796128991345 0.9350060766690576 0.2657366976150246 0.1266743042911767 0.1403531442218371 0.266209970857853 0.182300940685854 0.2040147905672061 +Organic anion transport 14 45 2.0452135413072536 0.0408338100514491 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 1.0 1.0 0.1608702453512187 0.0617533503296385 0.0017458649915946 +Mitochondrial calcium ion transmembrane transport 1 10 2.045111088653977 0.0408439073202755 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.0654311950523822 0.0727733471903131 0.0100519320580488 0.0565188023636715 0.1824124195300006 +Regulation of protein polymerization 19 60 2.04444899646198 0.0409092111578754 15.08980582524272 61.50728155339806 -0.0207642183528564 0.65203344430875 8.472639744149449 5.267361066990573 0.8559732965794926 0.3312375746436992 0.0268417318415177 0.0356350322701865 0.060852486256099 0.3205939982050357 0.0381834100887964 +Receptor mediated endocytosis 7 49 2.043205125233842 0.0410321366084136 10.939320388349516 54.74514563106796 0.2974076350556154 0.559708876603857 5.491273529430237 7.364675641797722 1.1085365989015756 0.3550743208777513 0.0259522941433995 0.0344781882608123 0.0585479504824452 0.0775429941700972 0.3249512392944268 +Positive regulation of release of sequestered calcium ion into cytosol 1 6 2.042430835884767 0.0411088136024124 2.2985436893203883 6.393203883495145 -0.0768098245406624 0.505909583507104 1.550351609206413 0.9832344223557812 0.9755496629465316 0.3017713651491867 1.0 1.0 0.1349531130589082 0.050241067872642 0.1646547004840289 +Positive regulation of calcium ion transport into cytosol 1 6 2.042430835884767 0.0411088136024124 2.4150485436893203 6.754854368932039 -0.1252435055298218 0.4951723805807685 1.6175814223208935 0.9682336676145236 0.993285888866281 0.3039119708047215 1.0 1.0 0.1596960736798767 0.0698282842903305 0.2186430557746356 +Negative regulation of leukocyte migration 0 5 2.0418426576292217 0.0411671413254699 1.5655339805825244 6.388349514563107 1.0839414642274992 0.2862432737648586 1.19995002173864 1.2770035444730965 0.9459956297737524 0.2624453160295969 0.0654311950523822 0.0727733471903131 0.1432798584585485 0.3258327648280404 0.5514871371697274 +Long chain fatty acyl coa biosynthetic process 0 7 2.041634741642307 0.0411877764414412 2.6067961165048543 6.645631067961165 0.2459085958317533 0.3937710552533847 1.6983008147735923 0.8926100812185768 1.1931980478816402 0.3084504867564762 0.0614672516091427 0.0683810764565047 0.1349531130589082 0.3090006421698555 0.5284199673110125 +Protein localization to endoplasmic reticulum 6 31 2.036605862956092 0.0416895547895057 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 0.2145999915509279 0.236404668572991 0.0173242512102645 0.0494987487524972 0.0202989209094577 +Locomotory behavior 9 26 2.0341231761104663 0.0419391777818403 7.186893203883495 29.01456310679612 0.367578136549174 0.4129867938447028 2.855164467106169 2.964970497634466 1.254834886476281 0.3178953925587394 1.0 0.3626106066392318 0.0632956597671369 0.028105003735856 0.0172768083770872 +Triglyceride biosynthetic process 0 5 2.0297194021773044 0.0423850695620153 1.4757281553398058 5.274271844660194 0.8957176915704722 0.2655240444557116 1.2274740041869927 1.2502497629633054 1.1422343750332298 0.2371147384530898 0.0927245527266703 0.1029565435856987 0.1993869387044997 0.4327587673805496 0.6843179386047307 +Chemical synaptic transmission postsynaptic 5 9 2.029417959064176 0.0424157374300711 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 1.0 1.0 0.2872333566147377 0.2089591760219589 0.0063839064386904 +Regulation of postsynaptic membrane potential 5 9 2.029417959064176 0.0424157374300711 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 1.0 1.0 0.2941077913158182 0.2179356607727124 0.0073521738882127 +Positive regulation of chemokine production 2 7 2.017146824366421 0.0436801934057893 1.703883495145631 7.002427184466019 1.1308330497685224 0.261365768238967 1.2206493839204828 0.948936007151574 0.9251734036107908 0.2478284645013121 0.0927245527266703 0.1029565435856987 0.1993869387044997 0.1067922158236129 0.0995129309927173 +Outer mitochondrial membrane organization 1 5 2.012305445928272 0.0441877487185138 1.4296116504854368 4.956310679611651 1.1531610290328034 0.2630141305877053 0.9963023114429655 0.2044029443827893 0.89744850896642 0.2676384061848394 0.0209136577273216 0.0233225886554715 0.0008973897437505 0.0056136137273067 0.0215767580713982 +Cellular transition metal ion homeostasis 3 15 2.0094889496468813 0.0444853054263472 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 0.2408640795463657 0.2648597161900051 0.4672829604777532 0.2100263434971256 0.3928956555746815 +Adult locomotory behavior 5 15 2.0070869096237183 0.0447404098172152 3.95873786407767 14.822815533980584 0.7389907423501648 0.3383620981823156 1.833016072372531 1.4878680371825237 1.1254592435779416 0.2897204029443448 1.0 0.1723099894081314 0.0065760397653667 0.0157211013123339 0.0122973883017787 +Endothelial cell migration 6 31 2.00704595476712 0.0447447700315586 6.412621359223301 35.5752427184466 0.4082848327362888 0.5352947559852537 3.4640505952618645 3.829708687407978 0.952730213605329 0.3344080805283456 0.0179550094378735 0.0240209396081081 0.1338452366906126 0.2185755644614827 0.4673315768782965 +Protein localization to lysosome 2 12 2.0055379667829336 0.0449055660826496 3.5364077669902914 14.37621359223301 0.6191344010889903 0.3619681772746835 2.0811532251007954 2.18038858944462 1.1869570048706093 0.3022181269423334 0.1449957667029796 0.1604648724397155 0.3009165941166509 0.0602711275874904 0.2698089294696847 +Positive regulation of epithelial cell migration 8 26 2.005482049777575 0.0449115378444651 5.648058252427185 28.92718446601942 0.4281502818361513 0.5649469814193326 3.094768701695654 4.042197186207753 0.7930122889691048 0.3121124271075066 0.0651781855143487 0.0789500483462739 0.2462273560384733 0.0334844539109541 0.0523654791856842 +Modified amino acid transport 1 5 2.004169175460723 0.045051941305606 2.029126213592233 5.587378640776699 1.6181581718562612 0.1578136127091599 1.2124460606928238 1.444653995706506 0.7704353439327314 0.2037484924456972 1.0 1.0 0.1758008751515455 0.0840389641709933 0.255405515221392 +Regulation of calcium ion transmembrane transport 3 19 2.003725413118686 0.0450994824458412 4.381067961165049 20.16747572815534 0.2677941306629663 0.6112981843507423 2.9466009420832906 2.782331640226771 0.7439672131804326 0.2863165715464626 0.2662696416305189 0.2922756805728106 0.1554832015057707 0.1017129224833184 0.4808642038976582 +Hormone metabolic process 8 26 2.001690848983059 0.0453179912109262 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.3376050929686426 0.3686542667077518 0.2391023108138102 0.0307176441592968 0.0470195984383086 +Lipoprotein metabolic process 8 18 1.9988561935179816 0.0456239156841402 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 1.0 1.0 0.1967082241040804 0.152340992243069 0.0224811621274596 +Central nervous system neuron development 2 12 1.9977528796200248 0.045743458171763 2.3640776699029127 11.609223300970871 0.0190214721993429 0.5388327448827857 2.176322469008906 1.840803006141132 0.915363202324922 0.298877761777515 0.1839914155887378 0.2031027035797352 0.0775813155228076 0.3264636262265684 0.4181534738954689 +Acute inflammatory response 3 5 1.993604222964147 0.0461953235093672 1.4466019417475728 4.689320388349515 0.9285034691739726 0.2315648833934721 0.949993922717463 0.5957637867345709 1.213201626775504 0.2269795845272838 0.0965594926942356 0.1071891284628969 0.2070995190727305 0.1147066696002357 0.1098061730973064 +Purine ribonucleoside metabolic process 1 7 1.9913772895305897 0.0464394240837293 2.063106796116505 7.834951456310679 1.2047777662844132 0.2574288772305114 1.199068432200366 0.6246876870736083 0.9870596763535292 0.2611531847589775 0.0693787843053731 0.0771453392642774 0.0113213926532688 0.0630532374058985 0.2004310968060411 +Ribonucleoside metabolic process 1 7 1.9913772895305897 0.0464394240837293 2.1189320388349513 8.12621359223301 1.1914157696469383 0.2635896161542528 1.2648845164842024 0.7462477223524518 0.9827848183963048 0.2624193088278075 0.0965594926942356 0.1071891284628969 0.0219975904219434 0.1147066696002357 0.3288847005661894 +Organic hydroxy compound biosynthetic process 11 48 1.9911054633728829 0.04646929395381 12.42233009708738 52.37135922330097 0.7934054609743442 0.424605725297311 4.713262264354627 5.1877801804871915 1.1130427360157376 0.3580104692277669 0.1052720139031065 0.1262869582908406 0.1316707557608008 0.0046371283427721 0.011572597953305 +Endoplasmic reticulum organization 10 39 1.989561414956343 0.046639270154271 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 1.0 1.0 0.0365585180593606 0.0024265102629424 0.0010841221766638 +Amino sugar metabolic process 1 9 1.9679630453219628 0.0490722898625408 2.366504854368932 7.844660194174757 0.0085981072516753 0.5583631064251566 2.142755783346253 1.3293350520649434 0.8362630845517884 0.2816860310761288 1.0 1.0 0.2297987482657219 0.1392702662277763 0.3827254031641982 +Response to toxic substance 7 47 1.9678736528330836 0.0490825769966172 10.449029126213592 47.61893203883495 0.2471625961982644 0.5593010307435107 5.121800353706628 3.557152076914045 0.9585220287488015 0.3332680862055938 0.0960066164215175 0.1154136911829446 0.006774840164175 0.0106977091616719 0.152186664829996 +Protein insertion into er membrane 3 11 1.9650330803715368 0.0494104089276017 4.451456310679611 12.691747572815531 0.9645901040516046 0.3077872373135509 2.16101217194965 1.431147904526304 1.1733171268605926 0.305304417896891 1.0 1.0 0.018640880521655 0.0155574138143109 0.0204068190514482 +Behavior 13 72 1.964993021164664 0.0494150452850918 16.990291262135923 75.04126213592232 0.2909440827671418 0.5405324846032677 5.526186812971979 8.403983472903677 1.109438409605415 0.3578193814797769 0.6853976969814264 0.364396393169234 0.1182369000459649 0.1229163582002179 0.1700468672785751 +Negative regulation of autophagy 3 20 1.9649411402961148 0.0494210503960579 5.063106796116505 24.313106796116504 0.449887145270975 0.5377284095479077 2.9855473971181983 2.929018368027943 0.8516059018543028 0.3205218740462018 0.0323108840780153 0.0037980660192356 0.0264876267470493 0.0799112808441097 0.2285487004354137 +Pteridine containing compound biosynthetic process 0 7 1.9626772284048688 0.0496836907241455 2.6067961165048543 8.104368932038835 0.160338473204254 0.4909996134440021 2.2749698444996973 0.914436714412676 1.0072278525407212 0.3042349018536225 0.0534900373740109 0.0595353304203936 0.1180585699575878 0.2740704871267072 0.1302253804689002 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8b69f7da19324aed4a9b0eae84ca36db8ca52b39 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 6362, + "title": "Average number of proteins per term", + "value": 18.2643822697265 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d1d834297e24e2a7e15865f05ffaa86785890694 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c434d591f1be59fa2464f6d46b33830da69178f3 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1990 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Anion transport 0.616809724412905 3.648760934054199 0.0002635081729034 0.8130024778050658 0.4662834071511374 63 P08183,Q14728,P21796,P45880,Q9UBX3,Q15042,Q9C0H2,P53985,Q9BQT8,O43826,Q96NB2,Q9UHG3,O43681,Q9Y5P4,O43865,Q99808,Q8TB61,Q9H2D1,Q4KMQ2,P07602,Q9Y6M7,Q9NZJ7,O75915 23 +Lipid localization 0.6156466162558912 3.6385680678779417 0.0002741581703469 0.8252560319414901 0.4662834071511374 63 P08183,P07602,Q14534,P04062,Q9NZJ7,P35790,O15118,Q14108,O43772,P23786,Q8WTV0,Q16739,Q4KMQ2,Q99720,Q9Y5P4,O15260,Q7Z3C6 17 +Anion transmembrane transport 0.6488962370121982 2.985778945850043 0.0028285703083237 0.9999999850844712 0.4662834071511374 43 P08183,Q14728,P21796,P45880,Q9UBX3,Q9Y6M7,O75915,Q8TB61,Q9H2D1,Q9BQT8,O43826,Q96NB2,Q9UHG3,P53985,Q4KMQ2 15 +Cell recognition 0.7128732480841535 2.9228083340255027 0.0034688997621861 0.9999999997494862 0.4662834071511374 23 P45880,Q9BY67,P78371,P05067,Q8WTV0 5 +Sphingolipid metabolic process 0.682743553449988 2.871892763030835 0.0040802139958167 0.9999999999949488 0.4662834071511374 27 P07602,P50897,P04062,Q9NZJ7,P16278,Q8NCC3,Q9NZ01,O95470,Q16739,Q99805,Q96G23,Q9Y5P4,Q13510 13 +Inorganic anion transport 0.6698668305770736 2.7640195588194527 0.0057094116891807 1.0 0.4662834071511374 24 P08183,P21796,P45880,Q9UBX3,Q9Y6M7,O43826,Q9C0H2,Q9UHG3,Q4KMQ2 9 +Membrane lipid metabolic process 0.6432271071169587 2.7568481036948835 0.0058361455399413 1.0 0.4662834071511374 36 P07602,P50897,P04062,Q9NZJ7,P16278,P04066,Q8NBX0,Q8NCC3,Q9NZ01,O95470,Q16880,Q16739,Q99805,Q96G23,Q9Y5P4,Q13510 16 +Regulation of stress activated protein kinase signaling cascade 0.6487100840730085 2.6464035973310227 0.0081352689459595 1.0 0.4662834071511374 26 Q96J02,P09429,Q96KB5,Q99873,O75915,P31689,P05067,P29372,P78318,P43034,O00560,Q53EL6,O75844 13 +Organophosphate ester transport 0.6398386941431226 2.6193034276717713 0.00881095369058 1.0 0.4662834071511374 29 P08183,Q9BSK2,Q96GC9,Q8TB61,Q9H2D1,Q14108,O43826,Q8WTV0,Q4KMQ2,Q9Y5P4,Q7Z3C6 11 +Phospholipid transport 0.772115047784419 2.5705898231032696 0.0101525494750107 1.0 0.4662834071511374 14 P08183,Q14108,Q8WTV0,Q4KMQ2,Q9Y5P4,Q7Z3C6 6 +Protein transmembrane transport 0.6513412892309325 2.551094071609833 0.0107385336433865 1.0 0.4662834071511374 23 Q15629,O60830,Q99595,Q9NS69,O14925 5 +Phosphatidylcholine metabolic process 0.7808486057873235 2.5477968750421427 0.0108405571138421 1.0 0.4662834071511374 13 P35790,Q8WTV0,Q8NCC3 3 +Negative regulation of calcium ion transmembrane transport 0.928423038980582 2.5333355312191874 0.0112982746608938 1.0 0.4662834071511374 6 P21796 1 +Regulation of blood pressure 0.7266318969760203 2.5229756689552607 0.0116366452152159 1.0 0.4662834071511374 17 Q9NZ08,Q9HB40,Q9UIQ6,P42785,P09601 5 +Lytic vacuole organization 0.6988299314848387 2.504321047408207 0.0122686651430206 1.0 0.4723887982540996 19 P10253,P50897,P04062,O14773,Q14108,O75503,Q96AX1 7 +Transition metal ion transport 0.8065839831240437 2.4904289363462713 0.0127589008162583 1.0 0.4803084437457711 10 O15173,Q9HD20 2 +Transition metal ion homeostasis 0.6940242885510368 2.477564690812315 0.0132282426176797 1.0 0.4911880584675403 19 P30519,P05067,P09601,O75880 4 +Neutral lipid biosynthetic process 0.9132301691427442 2.4729321507973228 0.0134009582425906 1.0 0.4928144297072946 6 Q8NCC3 1 +Lipid homeostasis 0.6509822558240544 2.459748126739062 0.0139034552556431 1.0 0.4969279194340759 22 P28340,O15118,Q8WTV0,Q96CP7,Q9NQC3,Q9BWH2,Q9H4M9,Q9Y5P4,O15260 9 +Negative regulation of calcium ion transport 0.8650741960537363 2.4487155618781498 0.0143366614309816 1.0 0.4969279194340759 8 P21796 1 +Protein insertion into membrane 0.634718776725643 2.4478283273545745 0.0143720115020229 1.0 0.4969279194340759 23 P46379,Q15629,Q9Y512,Q9NS69 4 +Glycerolipid biosynthetic process 0.5834222667598843 2.4439182549811145 0.014528718045367 1.0 0.4969446462614253 41 O00443,P37287,Q9Y217,Q96N66,P35790,Q8NCC3,Q99943,Q9NPH0,Q8WTV0,Q8TBX8,Q8WUK0 11 +Pigment metabolic process 0.6148855411514313 2.420912525020789 0.0154816022067489 1.0 0.504919643122657 25 P30519,P09601 2 +Leukocyte apoptotic process 0.7272599863593215 2.4131159063254786 0.0158167888329059 1.0 0.504919643122657 15 P24390 1 +Establishment of protein localization to membrane 0.4975476525913714 2.39344711568475 0.0166908873093565 1.0 0.504919643122657 76 P46379,P43307,A5D8V6,Q15629,Q8N4V1,P49458,Q12955,Q15042,O15118,P50542,O60725,Q9HD20,Q9Y512,O00560,Q9NS69 15 +Mitochondrial transmembrane transport 0.5189374253839288 2.3792816488051787 0.0173464164697738 1.0 0.504919643122657 54 Q9BPX6,Q9BSK2,P21796,O60830,Q99595,Q9H2D1,Q9BQT8,P23786,P00846,O75964,O43772,O14925 12 +Neuromuscular process 0.6056386289774635 2.373789801802089 0.0176065703673968 1.0 0.504919643122657 27 P10253,P04062,O14773,Q15334,P50542,P05067,P78417,O43251,O75844 9 +Intracellular protein transmembrane transport 0.6619898509427384 2.3669285847422388 0.0179363934749929 1.0 0.504919643122657 20 Q99595,Q15629,O60830,O14925 4 +Protein lipid complex subunit organization 0.9220312105239872 2.366825395889485 0.0179413948663094 1.0 0.504919643122657 5 Q9Y5X1 1 +Inflammatory response 0.4828853259353422 2.3615819133811833 0.018197151310582 1.0 0.504919643122657 60 Q96J02,P02786,P42785,P09601,Q13315,Q9UNH7,P60900,P28070,Q8N2K0,P15291,P05067,Q53EL6,Q12904,Q8IV08,P42345,Q96KB5,O15111,P09429,Q4KMQ2,P04062,Q9Y263 21 +Neuron projection guidance 0.6051822949921191 2.352549319625921 0.0186452169852784 1.0 0.504919643122657 24 P33176,P35613,P50552,Q13509,Q9BVA1,P42892,Q96TA1,P05067,Q9BPU6,P83731 10 +Regeneration 0.5988085645364022 2.345542889923906 0.0189993925099589 1.0 0.504919643122657 29 P00374,Q15648,P09601,Q96G23 4 +Regulation of monooxygenase activity 0.8041812826119977 2.338186311789136 0.0193775852769528 1.0 0.504919643122657 9 P00374,Q8WTV0 2 +Regulation of nitric oxide synthase activity 0.8786504863303073 2.3338238856634046 0.0196049455586311 1.0 0.504919643122657 6 P00374 1 +Vitamin transmembrane transport 0.8724261906635664 2.3085439303928417 0.020968902395718 1.0 0.504919643122657 6 Q8WTV0,Q9H2D1 2 +Vitamin transport 0.8724261906635664 2.3085439303928417 0.020968902395718 1.0 0.504919643122657 6 Q8WTV0,Q9H2D1 2 +Protein import into mitochondrial matrix 0.7968008550870681 2.3054242143638826 0.0211428266536681 1.0 0.504919643122657 9 Q99595,O60830 2 +Axon development 0.4881161448710072 2.2997225140700985 0.0214639457696521 1.0 0.504919643122657 76 P00374,Q9BVA1,Q12955,P42892,Q15334,P10586,P05067,Q96TA1,Q9NQC3,Q9UQB8,P43034,Q13509,P83731,Q96G23 14 +Leukocyte mediated cytotoxicity 0.7169098521080527 2.295333410828456 0.0217140242837172 1.0 0.504919643122657 14 P07437,P68371 2 +Mitochondrial transport 0.4874761684120571 2.2933333066919195 0.0218288230921108 1.0 0.504919643122657 76 O60830,P45880,Q9UBX3,Q99595,O43772,P23786,Q8N4H5,Q9Y512,P00846,O75964,O14925,Q9NS69,Q9UBE0 13 +Aminoglycan catabolic process 0.90218832891247 2.288720818790478 0.0220955786106407 1.0 0.504919643122657 5 P15586,P16278,P54802,P08236 4 +Glycosaminoglycan catabolic process 0.90218832891247 2.288720818790478 0.0220955786106407 1.0 0.504919643122657 5 P15586,P16278,P54802,P08236 4 +Positive regulation of oxidoreductase activity 0.8267763769930584 2.286499177300986 0.0222250722000987 1.0 0.504919643122657 8 P00374,Q8WTV0 2 +Protein targeting 0.5126314780370983 2.2851107831723354 0.0223063326833869 1.0 0.504919643122657 100 A5D8V6,Q99595,Q14108,Q8N4H5,P49257,Q9NS69,O60830,P49458,Q12955,O14925,P46379,P43307,Q15629,Q5JRX3,O60725,Q9Y512,O00560,Q9UBE0,P20645,P50542 20 +Regulation of jnk cascade 0.7371052452170487 2.2758910468904143 0.0228525314914855 1.0 0.504919643122657 12 Q96J02,P43034,P31689,P05067,P09429,O00560,Q53EL6 7 +Cell cell recognition 0.7249137386619846 2.2743083133442945 0.0229474556773652 1.0 0.504919643122657 13 P45880 1 +Sperm egg recognition 0.7362440601432385 2.2717021373972575 0.023104507011477 1.0 0.504919643122657 12 P45880 1 +Binding of sperm to zona pellucida 0.7362440601432385 2.2717021373972575 0.023104507011477 1.0 0.504919643122657 12 P45880 1 +Positive regulation of monooxygenase activity 0.8949168674476545 2.2599284718975476 0.0238256905063782 1.0 0.5068913293275944 5 P00374,Q8WTV0 2 +Regulation of oxidoreductase activity 0.6967962773624009 2.2558595585106036 0.0240794279495528 1.0 0.5072626510432297 15 P00374,Q8WTV0 2 +Iron ion homeostasis 0.7077453773485326 2.2487510015309575 0.0245283423529421 1.0 0.5078315061140778 14 P30519 1 +Glycoside metabolic process 0.7829493269952513 2.2435939262013824 0.0248585404150352 1.0 0.5078315061140778 9 Q9NUJ1,P04066,P08236,P04062 4 +Negative regulation of transport 0.4696355473315706 2.242624851007806 0.0249210163316622 1.0 0.5078315061140778 65 P21796,P78417,Q12955,O75915,P09601,Q9GZP9,Q15334,Q16850,P05067,P09429,O00560,P49257 12 +Intracellular lipid transport 0.781266508308205 2.2360517320863895 0.0253483826796345 1.0 0.5078315061140778 9 P23786,Q9Y5P4,O15118 3 +Triglyceride metabolic process 0.7513117763199839 2.2352257575864933 0.0254025312928762 1.0 0.5078315061140778 10 Q8WTV0 1 +Natural killer cell mediated immunity 0.7799308912091755 2.230060961857165 0.0257433960261901 1.0 0.5078315061140778 9 P07437,P68371 2 +Positive regulation of pattern recognition receptor signaling pathway 0.7795415057382271 2.2283136325467465 0.0258596078905579 1.0 0.5078315061140778 9 Q9Y4E8,Q9NUD5,Q9NQC3 3 +Sterol homeostasis 0.8123207229355246 2.224460742338925 0.0261174609767913 1.0 0.5078315061140778 8 Q8WTV0 1 +Negative regulation of stress activated protein kinase signaling cascade 0.7786547339142152 2.224333013762857 0.0261260470837538 1.0 0.5078315061140778 9 P43034,Q96KB5,P78318,Q53EL6,P31689 5 +Regulation of endothelial cell migration 0.5852429002569534 2.2217131700088486 0.0263026959401992 1.0 0.5078315061140778 24 Q8WTV0,O00443,P42785,P09601 4 +Response to reactive oxygen species 0.5772271648134812 2.2180835555719303 0.026549135837353 1.0 0.5078315061140778 31 P00374,P09601 2 +Protein transmembrane import into intracellular organelle 0.7014599836257098 2.2166558679781927 0.0266466167028784 1.0 0.5078315061140778 14 Q99595,O60830,O14925 3 +Sarcoplasmic reticulum calcium ion transport 0.8471011030267541 2.204930367719726 0.0274589811542349 1.0 0.5078315061140778 6 P78417 1 +Ceramide transport 0.8464476420446341 2.2022408232582107 0.0276483018129238 1.0 0.5083771564561322 6 P08183,P07602,Q9Y5P4 3 +Phenol containing compound metabolic process 0.7440050190199242 2.2009066352111724 0.0277426341144837 1.0 0.5086416087502754 10 Q9Y4G8 1 +Cellular response to camp 0.8789365814509782 2.1963320928814745 0.0280681822627939 1.0 0.5123571020054557 5 Q9Y4G8 1 +Skeletal muscle contraction 0.8788030168385687 2.1957987008721895 0.0281063546997648 1.0 0.5123571020054557 5 P78417 1 +Regulation of transmembrane transport 0.4655447996320145 2.189972704992258 0.0285262164164881 1.0 0.5183509994900893 60 P08183,P21796,Q12955,O75915,Q96GC9,Q15334,P05067,O43865,P78417,Q4KMQ2,P42858,O75844 12 +Glycerophospholipid catabolic process 0.8040999060138342 2.1889824733158703 0.0285981139297424 1.0 0.5183509994900893 8 Q8NCC3 1 +Aminoglycan metabolic process 0.6830945882208502 2.184172837415984 0.0289495500760195 1.0 0.5232302204080572 15 P16278,P04066,P54802,P08236,Q8NCH0,P15586,Q7LGA3 7 +Plasma membrane organization 0.5751001397254496 2.162728484825796 0.0305620688902286 1.0 0.5348389865731379 26 Q96GC9,Q9Y5X1,Q9UQB8,Q8WUX9,Q16739,Q4KMQ2,Q96CP7,Q7Z3C6 8 +Positive regulation of cation channel activity 0.8312612588492808 2.162556526226876 0.0305753050318857 1.0 0.5348389865731379 7 P78417,P42858 2 +Regulation of ion transmembrane transport 0.4993536156060188 2.159246572657276 0.0308310426552627 1.0 0.5348389865731379 53 P08183,P21796,Q12955,O75915,Q96GC9,Q15334,P05067,O43865,P78417,Q4KMQ2,P42858,O75844 12 +Protein targeting to membrane 0.568427586357735 2.1564323136461643 0.0310499237421086 1.0 0.5353377096132669 31 P46379,P43307,A5D8V6,Q15629,P49458,Q12955,P50542,O60725,O00560 9 +Glycoside catabolic process 0.8339592285242934 2.1506864489835578 0.0315009566634327 1.0 0.5384908306030934 6 Q9NUJ1,P04066,P08236,P04062 4 +Cellular hormone metabolic process 0.6665704066604984 2.1458843243046424 0.0318822087535235 1.0 0.5384908306030934 16 Q15648,Q9HB40,P42892,O95470,Q6NUM9,O60678 6 +Organic cation transport 0.865671605185723 2.1432095737118195 0.0320962738869736 1.0 0.5384908306030934 5 Q70HW3,O43772 2 +Blood vessel endothelial cell migration 0.6211213714842663 2.126741259084403 0.0334415873565208 1.0 0.54413140348385 20 Q8WTV0,P42785,P09601 3 +Cytosolic calcium ion transport 0.5837041106003622 2.1231282617781035 0.0337431053447736 1.0 0.5444524402172763 23 Q9BPX6,P78417,P21796 3 +Ceramide metabolic process 0.6418157785441857 2.119394350736702 0.0340571538394389 1.0 0.5444524402172763 18 P04062,Q8NCC3,O95470,Q9Y5P4,Q16739,Q96G23,Q99805,Q13510 8 +Calcium ion import 0.6822775216558012 2.1179662100047976 0.0341779294744737 1.0 0.5444524402172763 14 P21796,O75844 2 +Neuron projection regeneration 0.7138246143191419 2.1082208386181627 0.0350118915763795 1.0 0.5444524402172763 11 P00374,Q96G23 2 +Neuron migration 0.5661385692712542 2.107417299997263 0.0350814233189107 1.0 0.5444524402172763 27 Q9Y4G8,Q9BVA1 2 +Regulation of membrane lipid distribution 0.8180500763266293 2.107349271242315 0.0350873153865267 1.0 0.5444524402172763 7 P08183,Q4KMQ2,Q96CP7,Q7Z3C6 4 +Circulatory system process 0.4596863859301675 2.1059990123537693 0.0352044381401441 1.0 0.5449407188506017 68 P08183,Q9NZ08,P10253,Q9HB40,Q9UIQ6,P42785,P09601,P42892,P78417,O75844 10 +Glucosamine containing compound metabolic process 0.855021658212404 2.100343477645463 0.0356986372566354 1.0 0.5474453737397129 5 O60502 1 +Organic acid transmembrane transport 0.5615527524271501 2.0896653858691847 0.0366478684507318 1.0 0.5523963131188799 29 P08183,Q9UBX3,O75915,Q9H2D1,Q9BQT8,Q96NB2,P23786,P53985,O43772 9 +Positive regulation of inflammatory response 0.719904921784237 2.086749674945993 0.0369107683756759 1.0 0.5523963131188799 10 Q53EL6 1 +Protein targeting to mitochondrion 0.5354280691797603 2.076552646376925 0.0378428673002255 1.0 0.561770891975956 41 O60830,Q99595,Q5JRX3,Q8N4H5,Q9Y512,Q9NS69,O14925,Q9UBE0 8 +Vesicle transport along microtubule 0.7068685968952534 2.074391378198439 0.0380429773976624 1.0 0.561770891975956 11 P33176,P43034,Q92572,P42858 4 +Negative regulation of protein polymerization 0.5620754194334286 2.067308912540785 0.0387050549785925 1.0 0.561770891975956 24 P47755,P45880,Q9UEY8,P52907,P04350,P07737,Q6IBS0,Q13045,P35241,P35611,P35080 11 +Lipoprotein catabolic process 0.8465273610965041 2.0660173168303944 0.0388268445069672 1.0 0.561770891975956 5 Q9NUJ1,Q13315,P50897 3 +Central nervous system neuron differentiation 0.6514370035820618 2.063880615049503 0.0390290371350789 1.0 0.561770891975956 16 Q8NCM8,O14786,P50542,Q9Y4G8,P43034,O14949 6 +Peptide catabolic process 0.713973951415365 2.0584310866851174 0.0395487701730987 1.0 0.5623103727906632 10 Q9NZ08,Q9UIQ6,P42892 3 +Negative regulation of proteasomal protein catabolic process 0.5980943320572968 2.057619133107083 0.0396267085308001 1.0 0.5623103727906632 21 P46379,O00560,Q86UE8,Q96KB5,P78559,Q93009,O94966 7 +Tetrapyrrole metabolic process 0.6302475806400076 2.0535882786235273 0.0400155575708052 1.0 0.5623103727906632 18 P30519 1 +Fatty acid transmembrane transport 0.8434533893760103 2.053565519032483 0.0400177623034425 1.0 0.5623103727906632 5 P23786 1 +Sterol metabolic process 0.5489760482148479 2.053416352676555 0.0400322146718448 1.0 0.5623103727906632 34 Q14534,P04062,O15118,P16435,Q15800,Q16850,P05067,Q8WTV0,Q15392,P49748 10 +Chemokine production 0.7716087983204577 2.0473706301228276 0.0406217078085329 1.0 0.5623103727906632 8 P05067,P09601 2 +Organic anion transport 0.518819189985961 2.0452135413072536 0.0408338100514491 1.0 0.5623103727906632 45 Q14728,P07602,Q99808,Q9UBX3,Q9Y6M7,Q9NZJ7,O75915,Q8TB61,Q15042,Q9H2D1,Q9BQT8,Q96NB2,P53985,Q9Y5P4 14 +Mitochondrial calcium ion transmembrane transport 0.7111906123619919 2.045111088653977 0.0408439073202755 1.0 0.5623103727906632 10 P21796 1 +Regulation of protein polymerization 0.4510547282476511 2.0444489964619796 0.0409092111578754 1.0 0.5623103727906632 60 P45880,P52907,Q9Y5X1,P07900,Q14019,Q13045,P63000,O15145,P47755,P50552,P04350,Q7Z460,P46821,P07737,Q16625,Q9UQB8,P42345,Q6IBS0,P35611 19 +Receptor mediated endocytosis 0.503681035478255 2.043205125233842 0.0410321366084136 1.0 0.5623103727906632 49 Q5VW38,P20645,P50897,Q9Y5X1,Q14108,P05067,O00560 7 +Positive regulation of release of sequestered calcium ion into cytosol 0.8079611008097801 2.042430835884767 0.0411088136024124 1.0 0.5623103727906632 6 P78417 1 +Positive regulation of calcium ion transport into cytosol 0.8079611008097801 2.042430835884767 0.0411088136024124 1.0 0.5623103727906632 6 P78417 1 +Protein localization to endoplasmic reticulum 0.551483293541352 2.0366058629560917 0.0416895547895057 1.0 0.5665983641481819 31 P46379,Q15629,P49458,P24390,Q15042,Q9NQC3 6 +Locomotory behavior 0.5561744135040411 2.0341231761104663 0.0419391777818403 1.0 0.5676958490384426 26 P10253,P50897,Q8N2K0,O15118,P54802,Q15334,P05067,P43034,O75844 9 +Chemical synaptic transmission postsynaptic 0.7357181200135958 2.0294179590641757 0.0424157374300711 1.0 0.5681029926949733 9 Q99808,Q15042,Q15334,P05067,Q9UQB8 5 +Regulation of postsynaptic membrane potential 0.7357181200135958 2.0294179590641757 0.0424157374300711 1.0 0.5681029926949733 9 Q99808,Q15042,Q15334,P05067,Q9UQB8 5 +Positive regulation of chemokine production 0.7966330611445162 2.0171468243664212 0.0436801934057893 1.0 0.5775612503839992 7 P05067,P09601 2 +Outer mitochondrial membrane organization 0.8332949169222714 2.0123054459282717 0.0441877487185138 1.0 0.5820340731825777 5 Q9NS69 1 +Cellular transition metal ion homeostasis 0.6501697916579071 2.0094889496468813 0.0444853054263472 1.0 0.5847427957074813 15 P05067,P09601,O75880 3 +Adult locomotory behavior 0.6497214666808114 2.0070869096237183 0.0447404098172152 1.0 0.5855065650952603 15 P50897,O15118,P05067,P43034,O75844 5 +Endothelial cell migration 0.5473345814933299 2.0070459547671193 0.0447447700315586 1.0 0.5855065650952603 31 O00443,P42785,P09601,Q4VCS5,Q13685,Q8WTV0 6 +Protein localization to lysosome 0.6823614093710124 2.0055379667829336 0.0449055660826496 1.0 0.5855065650952603 12 Q14108,Q9NQC3 2 +Positive regulation of epithelial cell migration 0.5519936909268455 2.005482049777575 0.0449115378444651 1.0 0.5855065650952603 26 O00443,Q7Z460,P09601,Q13685,P07737,Q8WTV0,Q9NQC3,P09429 8 +Modified amino acid transport 0.8312966206680884 2.004169175460723 0.045051941305606 1.0 0.5855168719603321 5 Q9H2D1 1 +Regulation of calcium ion transmembrane transport 0.6113261403295154 2.003725413118686 0.0450994824458412 1.0 0.5855168719603321 19 P78417,P21796,P42858 3 +Hormone metabolic process 0.5514412011791513 2.001690848983059 0.0453179912109262 1.0 0.5860021546420995 26 Q15648,Q9HB40,P42892,P16435,O95470,Q6NUM9,O60678,O75844 8 +Lipoprotein metabolic process 0.6206885404589401 1.9988561935179816 0.0456239156841402 1.0 0.588761362236309 18 P37287,P50897,P04062,Q15042,Q9NUJ1,Q13315,Q16739,Q9Y4P8 8 +Central nervous system neuron development 0.6808092255547533 1.9977528796200248 0.045743458171763 1.0 0.5891090706250134 12 O14949,Q9Y4G8 2 +Acute inflammatory response 0.8287042090566907 1.993604222964147 0.0461953235093672 1.0 0.5897183986789991 5 P42785,P15291,Q4KMQ2 3 +Purine ribonucleoside metabolic process 0.7905517630463066 1.9913772895305897 0.0464394240837293 1.0 0.5897183986789991 7 Q13126 1 +Ribonucleoside metabolic process 0.7905517630463066 1.9913772895305897 0.0464394240837293 1.0 0.5897183986789991 7 Q13126 1 +Organic hydroxy compound biosynthetic process 0.5014937619937806 1.9911054633728829 0.04646929395381 1.0 0.5897183986789991 48 P00374,Q14534,P04062,P35270,P16435,Q15800,Q16850,Q9Y4G8,Q15392,Q14739,O00764 11 +Endoplasmic reticulum organization 0.5295925238656932 1.989561414956343 0.046639270154271 1.0 0.5898986813548159 39 P46379,Q15629,Q8N4V1,O95197,Q15042,P50542,Q9NQC3,O43681,P49257,Q9Y5P4 10 +Amino sugar metabolic process 0.722369811530496 1.9679630453219628 0.0490722898625408 1.0 0.5928083603732731 9 O60502 1 +Response to toxic substance 0.502455703132997 1.9678736528330831 0.0490825769966172 1.0 0.5928083603732731 47 P08183,P00374,Q15165,P07099,Q86WA6,P78417,Q6DKJ4 7 +Protein insertion into er membrane 0.6845573642419146 1.9650330803715368 0.0494104089276017 1.0 0.5928083603732731 11 P46379,Q15629,Q8N4V1 3 +Behavior 0.4505394699593173 1.9649930211646636 0.0494150452850918 1.0 0.5928083603732731 72 P53985,P10253,Q09472,P50897,P04062,O15118,P54802,Q9GZP9,Q15334,P05067,Q13641,P42858,O75844 13 +Negative regulation of autophagy 0.5941922196407471 1.9649411402961148 0.0494210503960579 1.0 0.5928083603732731 20 P09601,O15118,P10619 3 +Regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.751572016899306 1.958949955494219 0.0501186478413018 1.0 0.5928083603732731 8 P09601 1 +Porphyrin containing compound metabolic process 0.6400532099442495 1.9551348747256223 0.0505671529047471 1.0 0.5928083603732731 15 P30519 1 +Peptidyl arginine modification 0.7487034490966846 1.9462244365617167 0.0516277857827089 1.0 0.5928083603732731 8 Q9ULX3,Q99873,Q7L592,Q6P2P2,Q86X55,O60678 6 +Phosphatidylethanolamine metabolic process 0.9011132392899136 1.9459340503435971 0.0516626621090188 1.0 0.5928083603732731 4 P35790 1 +Macromolecule depalmitoylation 0.8152212474598752 1.9384821259922829 0.0525644294165885 1.0 0.5928083603732731 5 Q9NUJ1 1 +T cell differentiation 0.5893565744315272 1.9355943240554565 0.0529174060912396 1.0 0.5928083603732731 20 O96005,P04062,P24390,Q00534,P09429 5 +Smad protein signal transduction 0.7152630180251489 1.9350809932284148 0.0529803575085667 1.0 0.5928083603732731 9 Q9UIQ6,Q6PIU2,P08670,Q93062 4 +Lipid translocation 0.7824108568036537 1.9348402092793004 0.0530099071746725 1.0 0.5928083603732731 6 P08183,Q4KMQ2,Q7Z3C6 3 +Regulation of camp dependent protein kinase activity 0.7812492800020421 1.929921266927897 0.0536165939047585 1.0 0.5928083603732731 6 Q9Y4G8 1 +Regulation of response to osmotic stress 0.8130743838758401 1.929678443823508 0.053646692488712 1.0 0.5928083603732731 5 Q9BPX6,P08183 2 +Negative regulation of cell projection organization 0.5398270319346202 1.92576207991442 0.0541340883292913 1.0 0.5928083603732731 27 Q9NR77,Q96G23,Q9Y4G8,Q9NQC3 4 +Lysosomal transport 0.5297596843664456 1.925342669069747 0.0541865028501975 1.0 0.5928083603732731 35 P07602,P20645,O15118,Q14108,Q96AX1,Q8WUX9 6 +Membrane protein ectodomain proteolysis 0.684099207152977 1.9144600839715369 0.0555613946927424 1.0 0.5928083603732731 10 Q9Y5X1 1 +Iron ion transport 0.7400045190316059 1.907533643984129 0.0564515186147511 1.0 0.5928083603732731 8 O15173,Q8N4V1 2 +Cellular modified amino acid metabolic process 0.4670700100381955 1.9064590895749929 0.0565906686239743 1.0 0.5928083603732731 54 P00374,Q15648,P00390,Q9H2D1,Q8NCC3,P16435,Q16775,P23786,O60725,Q9UHG3,P78417,P48507 12 +Negative regulation of transmembrane transport 0.6522068837039355 1.9053569277901556 0.056733690114298 1.0 0.5928083603732731 13 Q12955,P78417,P21796 3 +Negative regulation of proteasomal ubiquitin dependent protein catabolic process 0.5946159436055416 1.904921833161872 0.0567902327055871 1.0 0.5928083603732731 19 P46379,Q86UE8,Q96KB5,P78559,Q93009,O00560 6 +Multicellular organismal movement 0.6817884154243694 1.90323312562555 0.0570101325476812 1.0 0.5928083603732731 10 P10253,P78417,P42345 3 +Grooming behavior 0.888980594651826 1.89921929687318 0.057535648588763 1.0 0.5928083603732731 4 P50897 1 +Negative regulation of ion transport 0.62791793825422 1.8895208016589384 0.0588220781407595 1.0 0.5928083603732731 15 Q12955,O75915,P78417,P21796 4 +Positive regulation of endothelial cell migration 0.6196008019786232 1.8889525121908324 0.0588981921261788 1.0 0.5928083603732731 16 O00443,Q8WTV0,P09601,Q13685 4 +Body morphogenesis 0.7351999504413338 1.8860997700541309 0.0592815113074425 1.0 0.5928083603732731 8 O95470,Q7Z460,Q15042 3 +Regulation of cell migration involved in sprouting angiogenesis 0.8018846305464664 1.8836758611336544 0.0596088335071618 1.0 0.5928083603732731 5 P09601 1 +Negative regulation of jnk cascade 0.8016285372965454 1.882620762066099 0.0597517806495271 1.0 0.5928083603732731 5 Q53EL6,P31689,P43034 3 +Regulation of defense response 0.4513125906662651 1.8803242072042432 0.0600639061160042 1.0 0.5928083603732731 80 Q96J02,Q8WXF1,Q13315,Q9UNH7,Q9Y3Z3,P60900,P28070,Q09472,Q9BY67,Q8N2K0,P19474,P05067,Q53EL6,O43657,P26583,O75844,Q96KB5,P09429,Q9Y4E8,Q9NUD5,Q9NZ08,Q15648,Q15233,P04062 24 +Establishment of protein localization to mitochondrial membrane 0.6458031909304308 1.87214664482594 0.0611863182844285 1.0 0.5928083603732731 13 Q9NS69 1 +Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.7668329366604616 1.8686772962099023 0.0616677245628318 1.0 0.5928083603732731 6 P09601 1 +Autophagy of mitochondrion 0.528659401733073 1.8649064870055465 0.062194513008591 1.0 0.5928083603732731 30 Q9BWH2,P21796,P42858,P04062 4 +Negative regulation of ion transmembrane transport 0.6536297815654274 1.8603916264336904 0.0628301385221581 1.0 0.5928083603732731 12 Q12955,P78417,P21796 3 +Response to wounding 0.4437888826311149 1.8601094021911857 0.0628700492281559 1.0 0.5928083603732731 75 P00374,Q96AY3,Q7Z460,P42785,P09601,P10586,Q8WTV0,Q8WUX9,Q9BWH2,Q4KMQ2,Q96G23 11 +Adult behavior 0.5656560644831117 1.8555804755496388 0.0635133787573511 1.0 0.5928083603732731 21 Q9UPY5,P50897,Q8N2K0,O15118,P05067,Q92542,P43034,O75844 8 +Regulation of cation channel activity 0.6207709597732132 1.8506697272769883 0.0642170817482803 1.0 0.5928083603732731 15 Q15334,P78417,P05067,P42858 4 +Positive regulation of response to cytokine stimulus 0.6964617715905528 1.847556122964188 0.0646665820822027 1.0 0.5928083603732731 9 P43034,Q15648 2 +Single fertilization 0.5415280022932548 1.8458740594162844 0.0649104940173139 1.0 0.5928083603732731 23 P45880 1 +Regulation of epithelial cell migration 0.5126361849061224 1.8408761522702788 0.0656397098724641 1.0 0.5928083603732731 38 O00443,Q7Z460,P42785,P09601,Q8WTV0,Q9NQC3 6 +Lipoprotein localization 0.8733500693765894 1.8387700196256316 0.0659490196432637 1.0 0.5928083603732731 4 A6NIH7,O15260 2 +Mucopolysaccharide metabolic process 0.7238901616460905 1.8354675544810024 0.0664364422341257 1.0 0.5928083603732731 8 Q8NCH0,P16278 2 +Regulation of autophagy 0.4490919211427587 1.8346299467876117 0.0665605383759544 1.0 0.5928083603732731 82 O00443,P21796,P09601,Q15042,Q9Y487,P10619,P42858,Q09472,O15118,O75844,Q93050,Q9UBQ0,P09429,P07602,Q86UE8,Q05639,P04062,Q9NZJ7,P21281,Q8TBX8 20 +Regulation of epithelial cell apoptotic process 0.6582316701141929 1.8343652451177952 0.0665997950455985 1.0 0.5928083603732731 11 Q53EL6,P09601 2 +Inorganic anion transmembrane transport 0.6934971860345907 1.833685687407512 0.0667006643989045 1.0 0.5928083603732731 9 O43826,Q9UHG3,Q9UBX3 3 +Positive regulation of jnk cascade 0.8720219753562837 1.833620346041682 0.0667103698943347 1.0 0.5928083603732731 4 O00560,P05067 2 +Cerebellar cortex development 0.6575430580604978 1.8309242315446417 0.0671118529907914 1.0 0.5928083603732731 11 O14949,P04062 2 +Cellular metabolic compound salvage 0.6926492925819409 1.8297152165199624 0.0672925343299075 1.0 0.5928083603732731 9 Q13126 1 +Establishment of protein localization to vacuole 0.5906621692228881 1.8248854350293793 0.0680183195899868 1.0 0.5928083603732731 18 Q14108,P20645 2 +Endothelial cell proliferation 0.6264640254932171 1.8245909810197964 0.0680627754469442 1.0 0.5928083603732731 14 P09601 1 +Negative regulation of cation channel activity 0.7871165287909428 1.822669668471339 0.0683534368641027 1.0 0.5928083603732731 5 P78417 1 +Endoplasmic reticulum tubular network organization 0.6651027566718721 1.8217892035240335 0.0684869765599427 1.0 0.5928083603732731 10 Q15042,Q9NQC3,O95197 3 +Positive regulation of pathway restricted smad protein phosphorylation 0.8681665585608458 1.8186593761471668 0.0689634130784659 1.0 0.5954847674647459 4 Q93062 1 +Secondary alcohol metabolic process 0.5095126781057243 1.816723899001572 0.0692594004306377 1.0 0.5954847674647459 38 Q14534,P04062,O15118,P16435,Q15800,Q16850,P05067,Q8WTV0,Q15392,P49748 10 +Ventricular system development 0.6635657792591619 1.814254303337954 0.069638583306157 1.0 0.5954847674647459 10 Q00534,Q9Y4G8,Q96N66 3 +Negative regulation of macroautophagy 0.6881498932792023 1.808620362308276 0.0705100028492258 1.0 0.595613387784471 9 P09601 1 +N acetylglucosamine metabolic process 0.8643050925217641 1.8036577989306937 0.071284969095752 1.0 0.5990950771296885 4 O60502 1 +Steroid metabolic process 0.4226704811619587 1.795922711541095 0.0725068098422123 1.0 0.603935320219798 62 Q14534,Q15648,P04062,O15118,P16435,Q15800,O95470,Q16850,Q8WTV0,P05067,Q9UHI6,Q15392,P49748,Q14739 14 +Positive regulation of actin filament polymerization 0.6409104101525842 1.795449005807011 0.0725821905314552 1.0 0.603935320219798 12 Q9UQB8,P50552,Q9Y5X1,P07737 4 +Peptidyl arginine n methylation 0.7489220563847525 1.792098030335376 0.073117264360643 1.0 0.603935320219798 6 Q99873,Q6P2P2,Q7L592,Q86X55,O60678 5 +Peptidyl arginine methylation 0.7489220563847525 1.792098030335376 0.073117264360643 1.0 0.603935320219798 6 Q99873,Q6P2P2,Q7L592,Q86X55,O60678 5 +Protein depalmitoylation 0.8601925187987138 1.7876621219986029 0.0738305363328328 1.0 0.603935320219798 4 Q9NUJ1 1 +Ameboidal type cell migration 0.4276986215468147 1.7874922333704009 0.0738579662877405 1.0 0.603935320219798 67 O00443,P43034,Q7Z460,P42785,P09601,Q4VCS5,Q13685,O95470,Q8WTV0,Q9NQC3,Q13641,Q9P258 12 +Sulfur compound biosynthetic process 0.493452477266197 1.786816320649862 0.0739671806350479 1.0 0.603935320219798 43 Q13126,P50897,Q8TB61,Q9NZ01,Q16775,Q8NCH0,P48507 7 +Folic acid metabolic process 0.7423806961504258 1.7848914887096154 0.0742789194918913 1.0 0.603935320219798 7 P00374 1 +Positive regulation of cell migration involved in sprouting angiogenesis 0.8593571963585827 1.7844108610214782 0.0743569275159277 1.0 0.603935320219798 4 P09601 1 +Protein localization to mitochondrion 0.4623530217860579 1.783998129870786 0.0744239690431187 1.0 0.603935320219798 52 O60830,Q99595,Q8N4H5,Q9Y512,Q9NS69,O14925,Q9UBE0 7 +Long chain fatty acyl coa metabolic process 0.6820926340358779 1.7801551142680618 0.0750505788901378 1.0 0.6064070445110084 9 Q9NZ01 1 +Taxis 0.4245732802050068 1.7790446888843243 0.0752324356426983 1.0 0.6064070445110084 65 P33176,P35613,P09429,Q09472,Q9BVA1,P42892,Q4VCS5,Q4KMQ2,Q96TA1,P05067,Q13641,Q13509,P83731 13 +Export across plasma membrane 0.7113107085456573 1.7788649394514766 0.0752619073985574 1.0 0.6064070445110084 8 P08183 1 +Regulation of nervous system process 0.6561647235286356 1.777895440285302 0.0754210292542691 1.0 0.6064070445110084 10 P05067,P04062,Q9UQB8 3 +Nervous system process 0.4551038889177273 1.7751213042027658 0.07587786001536 1.0 0.6064070445110084 93 Q9Y6M9,Q15042,Q14108,Q15334,Q13641,P42858,Q09472,Q12955,P05067,Q9UQB8,P43034,P78417,O75844,Q99808,P50897,Q9H6K4,Q14168,P10253,P04062,O14773,P50542,O43251 22 +Neuron recognition 0.7445921358631974 1.7735063718996993 0.0761448369853643 1.0 0.6064070445110084 6 P35613,P05067,Q9NQC3 3 +Negative regulation of protein containing complex assembly 0.5038550512119369 1.7728495725743605 0.0762536365307775 1.0 0.6064070445110084 38 P47755,Q09472,P45880,Q9UEY8,P04062,P52907,P04350,P07737,Q6IBS0,Q13045,P35241,P50542,Q15058,P35611,P09429,P35080 16 +Vasoconstriction 0.7748127994237756 1.7715987725069475 0.0764611836111961 1.0 0.6072984396185142 5 P42892 1 +Response to camp 0.6795632892127674 1.7682464813357102 0.0770197066763527 1.0 0.6075922570815614 9 P35613,P05067,Q9Y4G8 3 +Cerebellar purkinje cell layer development 0.7382774179876723 1.767116837960166 0.0772086631707957 1.0 0.6079226671938153 7 O14949,P04062 2 +Protein targeting to vacuole 0.6041585081806775 1.7597823575963891 0.078444715505306 1.0 0.6146124138482232 15 Q14108,P20645 2 +Embryonic heart tube development 0.7713804394497181 1.757313230986965 0.0788644338062294 1.0 0.6163827123774345 5 P42892,Q15648 2 +Cellular amino acid biosynthetic process 0.5125342899379761 1.7557733959834625 0.0791271087195002 1.0 0.6174373873746045 31 Q13126,P00374 2 +Regulation of lipid catabolic process 0.7401702432370374 1.7544890502284156 0.0793467445179172 1.0 0.6174373873746045 6 Q8WTV0 1 +Positive regulation of response to external stimulus 0.4171543565953062 1.7503186321711115 0.0800633475958885 1.0 0.6180422503955001 61 P09429,Q09472,Q15233,Q15648,Q9BY67,P05067,Q13641,Q53EL6,Q4KMQ2,Q9Y4E8,Q9NUD5 11 +Learning 0.5484042301751532 1.7464745199195288 0.0807285308625682 1.0 0.6180422503955001 21 Q13641,P05067,P42858,P50897 4 +Alcohol biosynthetic process 0.5088804834013372 1.7464481367389106 0.0807331116539367 1.0 0.6180422503955001 33 P00374,P04062,P35270,P16435,Q15800,Q16850,Q15392,Q14739 8 +Protein targeting to lysosome 0.6495910095957123 1.745497317905327 0.0808983389182482 1.0 0.6180422503955001 10 Q14108 1 +Forebrain generation of neurons 0.7683066089675851 1.7445060448342626 0.0810708882789421 1.0 0.6180422503955001 5 Q9Y4G8 1 +Water soluble vitamin metabolic process 0.567603543084952 1.7431260287263917 0.0813116028970735 1.0 0.6187851885540451 19 P00374,P78417,Q9H2D1,O00764 4 +Pteridine containing compound metabolic process 0.584878339628342 1.7403724296884675 0.0817936434172166 1.0 0.6217098678857015 17 P00374,Q9NRN7,Q9H2D1 3 +Positive regulation of macroautophagy 0.5759409460367704 1.7384936994026217 0.0821238593228514 1.0 0.6227318152705378 18 P21796,P09601,P42858,Q8TBX8 4 +Glycerophospholipid biosynthetic process 0.5029711709170083 1.7366617949752383 0.0824468850889823 1.0 0.6236945100310413 36 O00443,P37287,Q9Y217,Q96N66,P35790,Q99943,Q13315,Q9NPH0,Q8TBX8,Q8WUK0 10 +Negative regulation of secretion 0.6097715049398724 1.7351183382938298 0.0827198467812173 1.0 0.6250162294799345 14 P09601 1 +Chloride transport 0.6473515899720649 1.734438586716284 0.082840293553716 1.0 0.625183804968851 10 P08183,Q4KMQ2,Q9UHG3 3 +Calcium import into the mitochondrion 0.7305010361767716 1.733355317652696 0.0830325342251363 1.0 0.6258921596449258 7 P21796 1 +Positive regulation of autophagy of mitochondrion 0.7648757181897594 1.7301959205148438 0.0835952769717747 1.0 0.6281417487486781 5 P21796 1 +Positive regulation of autophagy 0.5123726686211943 1.7300173754313963 0.083627170888106 1.0 0.6281417487486781 26 O00443,P21796,P09601,Q15042,Q8TBX8,P42858 6 +Cell migration involved in sprouting angiogenesis 0.700120229771346 1.7282670173914194 0.0839403634371116 1.0 0.6290089425051877 8 P09601 1 +Positive regulation of necrotic cell death 0.8440918939816504 1.7248616614631709 0.0845524061911688 1.0 0.6328498919861371 4 Q7Z3C6 1 +Tissue migration 0.4698787448149795 1.7184204397869256 0.0857199547623783 1.0 0.639060877523988 48 O00443,Q7Z460,P42785,P09601,Q4VCS5,Q13685,Q8WTV0,Q9NQC3 8 +Diol metabolic process 0.7262094223503451 1.7146814860848063 0.0864036397516216 1.0 0.6405812413501001 7 P00374,P35270,P04062 3 +Diol biosynthetic process 0.7262094223503451 1.7146814860848063 0.0864036397516216 1.0 0.6405812413501001 7 P00374,P35270,P04062 3 +Folic acid containing compound metabolic process 0.6058894269086135 1.7142024173058747 0.0864915571077862 1.0 0.6405812413501001 14 P00374 1 +Barbed end actin filament capping 0.6676014207677933 1.711753419521857 0.0869421195204593 1.0 0.6428336496288063 9 P47755,P52907,Q6IBS0,Q13045,P35241,P35611 6 +Cellular response to reactive oxygen species 0.5086441441029843 1.7099072013352543 0.0872830345778934 1.0 0.643155904303916 28 P00374 1 +Polyol biosynthetic process 0.6334013764705715 1.7095741132146065 0.0873446559758854 1.0 0.643155904303916 11 P00374,P35270,P04062 3 +Neuron projection arborization 0.7242589711428749 1.7061850099336489 0.0879736387768073 1.0 0.6452376992456267 7 Q13641,Q15334 2 +Regulation of dna binding 0.5084920284300494 1.7052113603529868 0.0881550120224901 1.0 0.6452376992456267 27 Q09472,P09601,Q96TA1,O75844,Q12948 5 +Vacuolar transport 0.4778031497289209 1.704686516265271 0.0882529059451731 1.0 0.6452376992456267 45 P07602,P20645,Q9NZJ7,O15118,Q14108,Q96AX1,Q8WUX9 7 +Positive regulation of erk1 and erk2 cascade 0.5700030321279307 1.7034516197051912 0.0884835845827536 1.0 0.6452376992456267 18 P18615,P09429,P05067,Q9Y4G8,Q96AC1,Q13641 6 +Heart morphogenesis 0.5082384449644581 1.6993695355628513 0.0892495782805304 1.0 0.6496634062022139 25 P10253,Q15648,Q53EL6,Q9Y5P4,O75844 5 +Cellular response to nutrient 0.7256929862853269 1.6920152939179398 0.0906430576070373 1.0 0.6567497273067707 6 P09601 1 +Membrane invagination 0.6200327626119967 1.6879822826540332 0.0914146300304135 1.0 0.6600208040822643 12 Q9Y5X1 1 +Positive regulation of endothelial cell proliferation 0.690112864290744 1.6828305246064434 0.0924079040864889 1.0 0.66459984008758 8 P09429,O14786,P09601 3 +Regulation of ion transport 0.42294614173199 1.677661928134956 0.0934131157826727 1.0 0.6662491509073588 72 P08183,P21796,Q12955,O75915,Q96GC9,Q15042,Q15334,P05067,O43865,P78417,Q4KMQ2,P42858,O75844 13 +Regulation of striated muscle cell differentiation 0.6883767858003852 1.674930677841151 0.0939478336883048 1.0 0.6672003064130603 8 Q9UGN5,Q96TA1 2 +Ion transmembrane transport 0.4956120574434319 1.6732373310737816 0.094280584009013 1.0 0.6672003064130603 147 P08183,Q14728,P21796,P45880,Q9UBX3,O14548,Q15334,Q9C0H2,P53985,P00846,O75964,P42858,Q96ES6,Q8N4V1,Q12955,P00403,Q9BQT8,O43826,P05067,Q9HD20,Q9UHG3,Q70HW3,P78417,O43865,O75844,Q8TB61,Q9H2D1,Q4KMQ2,Q9UDW1,Q9BPX6,Q9Y6M7,Q96GC9,P21281,O43772 34 +Second messenger mediated signaling 0.503875285068327 1.668746468938294 0.0951676356168911 1.0 0.6681578143085647 25 P78417,Q9Y4G8,O75844 3 +Membrane lipid biosynthetic process 0.5149992744883886 1.6676055333691668 0.0953940590939326 1.0 0.6681578143085647 23 P04062,Q8NBX0,O95470,Q16880,Q16739,Q96G23,Q99805,Q13510 8 +Regulation of macroautophagy 0.4636534015995177 1.6640129394327945 0.0961098436063523 1.0 0.6695677064483965 48 P21796,P04062,Q93050,P09601,O15118,Q15042,P21281,Q8TBX8,P42858 9 +Protein localization to axon 0.828388811186924 1.6633552972826309 0.0962413357617446 1.0 0.6695677064483965 4 Q12955,O14579 2 +Protein neddylation 0.7141622074835615 1.662108229389383 0.0964910758406822 1.0 0.6695677064483965 7 Q96GG9,Q9BTE7 2 +Phosphate ion transmembrane transport 0.8276774183932474 1.660563270796192 0.0968011907715729 1.0 0.6695677064483965 4 Q9UBX3 1 +Phosphate ion transport 0.8276774183932474 1.660563270796192 0.0968011907715729 1.0 0.6695677064483965 4 Q9UBX3 1 +Protein localization to vacuole 0.5437023745647667 1.654340672069148 0.098058313509777 1.0 0.6695677064483965 20 Q14108,P20645,Q9NQC3 3 +Liposaccharide metabolic process 0.561487063248689 1.6530064030853926 0.0983295604256491 1.0 0.6695677064483965 18 P04062,P16278,P04066,Q8NBX0,Q16880,Q16739,Q99805 7 +Base excision repair 0.5433690816418754 1.6522609762878695 0.0984813608360042 1.0 0.6695677064483965 20 Q96T60,Q86W56,Q9UGN5,P28340,Q96K76,P23396,P12004,Q07864,P29372,P35244,P15927 11 +Regulation of hormone levels 0.4219648188774597 1.6470099602407005 0.099555998584357 1.0 0.6695677064483965 58 Q9UBM7,P53985,Q9UNH7,Q9HB40,O00330,P17858,P16435,Q12904,O60678,O75844,P62820,Q8NBQ5,Q9BTZ2,Q15648,Q9HBH5,P42892,O15382,P50416,P22059,O95470,Q96TA1,Q6NUM9 22 +Positive regulation of toll like receptor signaling pathway 0.7449589402194008 1.6468194172219557 0.0995951690346401 1.0 0.6695677064483965 5 Q9NQC3 1 +Mitotic dna replication 0.6292396913377272 1.6446028456996018 0.1000517396399964 1.0 0.6700307027259553 10 O75844,Q14566 2 +Cytokine production involved in inflammatory response 0.8233644343580933 1.6436260242591236 0.1002534749415373 1.0 0.670563797732329 4 Q53EL6 1 +Forebrain neuron development 0.8220894150385123 1.6386157610111958 0.101293307797194 1.0 0.6712222090903099 4 Q9Y4G8 1 +Forebrain neuron differentiation 0.8220894150385123 1.6386157610111958 0.101293307797194 1.0 0.6712222090903099 4 Q9Y4G8 1 +Platelet morphogenesis 0.7087838585602682 1.6385670444051603 0.1013034604772273 1.0 0.6712222090903099 7 Q96AX1 1 +Regulation of response to external stimulus 0.4700963272770053 1.635018976854714 0.1020450695368808 1.0 0.6712222090903099 122 Q9BVA1,Q8WXF1,Q13315,Q13641,Q9Y3Z3,P60900,P28070,Q09472,Q9BY67,Q7Z460,P80303,P05067,Q53EL6,O43657,Q96G23,O75844,Q96KB5,P09429,Q4KMQ2,Q9Y4E8,Q9NUD5,Q9NZ08,Q15648,Q15233,P04062,P10586 26 +Response to hydrogen peroxide 0.5093869684718637 1.6295370221997614 0.1031993841089382 1.0 0.6740805766951388 23 P09601 1 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.7103466061797894 1.625455467118872 0.104065545383631 1.0 0.6769580774342131 6 P46379 1 +Dendrite morphogenesis 0.4953524172115627 1.6234560364049495 0.1044919541585043 1.0 0.678344706486127 30 Q15334,Q9Y4G8,Q9UQB8,Q13641,O43251 5 +Carbohydrate derivative transport 0.5642950610274253 1.6213054603996702 0.1049521445554062 1.0 0.6793968426078149 17 P07602,Q9NZJ7,Q8TB61,O43826,Q8WTV0 5 +Negative regulation of blood pressure 0.8175564874232697 1.6207917891171149 0.1050623000413273 1.0 0.6793968426078149 4 P42785 1 +Protein catabolic process in the vacuole 0.8171031292447348 1.6190081586968557 0.1054455076984886 1.0 0.6793968426078149 4 P04062 1 +Lysosomal protein catabolic process 0.8171031292447348 1.6190081586968557 0.1054455076984886 1.0 0.6793968426078149 4 P04062 1 +Modulation of excitatory postsynaptic potential 0.8165863236561087 1.6169746963936882 0.1058837429997274 1.0 0.6793968426078149 4 P05067,Q9UQB8 2 +Regulation of calcium ion transport 0.4950582004739733 1.6162406529763602 0.1060422924724238 1.0 0.6793968426078149 29 P78417,P21796,P42858 3 +Cellular carbohydrate catabolic process 0.5708908369274968 1.615286909970994 0.1062485770496641 1.0 0.6796852716974242 16 Q14108,Q9NUJ1,P10253 3 +Positive regulation of stress activated protein kinase signaling cascade 0.647258082374896 1.615044854628647 0.1063009816628319 1.0 0.6796852716974242 9 Q99873,O75915,P05067,P09429,O00560 5 +Body fluid secretion 0.6141531919079845 1.611876592488565 0.1069887967687548 1.0 0.680661613240027 11 P00403,Q13505,Q15648 3 +Secondary metabolic process 0.7026397198914835 1.6116229320838158 0.1070440173861342 1.0 0.680661613240027 7 P40616,Q9Y4G8,Q9UPY5 3 +Feeding behavior 0.7068561958329505 1.6102715358620447 0.1073385903857238 1.0 0.680661613240027 6 Q9GZP9 1 +Lactation 0.6216226011582713 1.6066201713087056 0.1081377148622291 1.0 0.680661613240027 10 P00403,Q13505,Q15648 3 +Epithelial cell apoptotic process 0.5858894048421358 1.6058326234322229 0.1083106905813537 1.0 0.680661613240027 14 Q53EL6,P09601 2 +Sphingolipid biosynthetic process 0.5760333330561029 1.60414508318341 0.1086820764125022 1.0 0.680661613240027 15 P04062,P22059,O95470,Q16880,Q16739,Q96G23,Q99805,Q13510 8 +Ceramide biosynthetic process 0.6438110844710028 1.598583886820223 0.1099130923755544 1.0 0.680661613240027 9 Q16739,Q96G23,P04062,Q13510 4 +Negative regulation of cytokine production 0.5046948378331932 1.5976207625200118 0.1101274028260137 1.0 0.680661613240027 23 Q53EL6,P09601 2 +Glycosphingolipid metabolic process 0.6435866675052586 1.5975114782122712 0.1101517411617121 1.0 0.680661613240027 9 P04062,P16278,Q16880,Q16739,Q99805,P06280 6 +Regulation of inflammatory response 0.4917624228127957 1.5971459250244149 0.1102331831490432 1.0 0.680661613240027 30 P60900,P28070,Q96KB5,P04062,Q13315,P05067,Q53EL6 7 +Pathway restricted smad protein phosphorylation 0.7036704993199915 1.59639912772189 0.1103997107775267 1.0 0.680661613240027 6 O00560,Q93062 2 +Entry into host 0.489751433857733 1.5952659523613049 0.1106527759379589 1.0 0.680661613240027 32 Q96J02,P35613,O14786,P02786,P14373,O15118,P19474,Q14108,Q9BTY2,Q8WTV0,P15151 11 +Organic hydroxy compound transport 0.5043385919306228 1.595194299577224 0.1106687931048937 1.0 0.680661613240027 23 Q14728,Q8WTV0,O15118 3 +Cellular hyperosmotic response 0.7033652009681934 1.5950689856675135 0.1106968100087373 1.0 0.680661613240027 6 Q9BPX6 1 +Negative regulation of proteolysis involved in cellular protein catabolic process 0.4933043309583755 1.5950032390176658 0.1107115114754424 1.0 0.680661613240027 26 P46379,O00560,Q86UE8,Q96KB5,P78559,O94966,O15372,Q93009,Q96HY6,P62829 10 +Fatty acyl coa biosynthetic process 0.6020591553493162 1.5946500350717792 0.1107905170405789 1.0 0.680661613240027 12 Q9NZ01 1 +Glycosylceramide metabolic process 0.8104076897580331 1.5926465721008352 0.1112394995330996 1.0 0.6807783966981421 4 Q16880,Q16739,P04062 3 +Proteoglycan metabolic process 0.7027604555286875 1.592433840653677 0.1112872575551819 1.0 0.6807783966981421 6 Q8NCH0,Q7LGA3 2 +Proteoglycan biosynthetic process 0.7027604555286875 1.592433840653677 0.1112872575551819 1.0 0.6807783966981421 6 Q8NCH0,Q7LGA3 2 +Response to arsenic containing substance 0.5922363822983215 1.5901588859295115 0.1117989953373146 1.0 0.6813780586761581 13 P09601 1 +Thyroid hormone mediated signaling pathway 0.9675389201722436 1.5866299394033114 0.1125964824727525 1.0 0.6813780586761581 2 P42785 1 +Determination of adult lifespan 0.6684095387262149 1.5837180526260983 0.113257894781225 1.0 0.6813780586761581 8 O75844,Q13315,P04062 3 +Regulation of autophagy of mitochondrion 0.6085975761791931 1.5835331175908158 0.1133000044870118 1.0 0.6813780586761581 11 P21796 1 +Response to purine containing compound 0.5811791270307325 1.5801671047744863 0.1140686029295356 1.0 0.6813780586761581 14 P35613,P05067,Q9Y4G8,Q86X55 4 +Cholesterol efflux 0.6999153476308256 1.5800301828778387 0.1140999544715275 1.0 0.6813780586761581 6 Q8WTV0 1 +Establishment of protein localization to endoplasmic reticulum 0.5407628669713976 1.5799825733737267 0.1141108573951723 1.0 0.6813780586761581 19 P46379,Q15629,Q15042,P49458 4 +Metal ion homeostasis 0.4122374750673609 1.5764608891075471 0.1149196254258908 1.0 0.6813780586761581 71 Q9BPX6,P30519,O75880,P09601,Q15334,P05067,Q9HD20,Q9Y487,P78417,P42858 10 +Membrane protein proteolysis 0.5887872572949839 1.571764483349555 0.1160051812269111 1.0 0.6869446130537555 13 Q9NZ08,Q16740,Q9Y5X1,Q8TCT9,Q9H300 5 +Regulation of calcium ion transport into cytosol 0.6378476307650229 1.57005749365671 0.1164017362657978 1.0 0.6876024569387242 9 P78417 1 +Regulation of release of sequestered calcium ion into cytosol 0.6378476307650229 1.57005749365671 0.1164017362657978 1.0 0.6876024569387242 9 P78417 1 +Regulation of response to extracellular stimulus 0.726423310877172 1.5687947894361054 0.1166957629261311 1.0 0.6880615789954091 5 P80303 1 +Neuron maturation 0.7260204860528684 1.5670949279794653 0.1170925045762967 1.0 0.6897615871429627 5 O75503,P05067 2 +Response to dexamethasone 0.6366594722483793 1.5643667623843804 0.1177314616513005 1.0 0.6922435850513624 9 Q9H7B4,P04062 2 +Positive regulation of ion transport 0.4770729008982584 1.5630546083720216 0.1180397509264825 1.0 0.6928879884246256 38 P08183,Q12955,Q96GC9,Q15042,Q9Y3S1,O43865,P78417,Q4KMQ2,P42858 9 +One carbon metabolic process 0.5954560806637728 1.5601861809665625 0.118715890299756 1.0 0.6934883874804155 12 P00374 1 +Glucosylceramide metabolic process 0.9602517389864194 1.557698472488788 0.1193047427850251 1.0 0.6946259473454043 2 P04062 1 +Regulation of blood circulation 0.487899123262858 1.5564649906184018 0.1195975613591966 1.0 0.6946259473454043 24 P78417,O75844,P10253 3 +Negative regulation of ubiquitin dependent protein catabolic process 0.487628352104677 1.5545584281328388 0.1200512711095269 1.0 0.6946259473454043 24 P46379,O00560,Q86UE8,Q96KB5,P78559,O15372,Q93009,Q96HY6,P62829 9 +Regulation of muscle organ development 0.6346010662974121 1.5545024572994042 0.1200646109745524 1.0 0.6946259473454043 9 P16989,Q96TA1,P49454 3 +Cellular response to arsenic containing substance 0.6342909706893405 1.553015817168275 0.1204193558805364 1.0 0.6946943034515618 9 P09601 1 +Regulation of anion transport 0.6616986771436449 1.5529237928898292 0.1204413418275813 1.0 0.6946943034515618 8 P08183,Q15042,O43865 3 +Muscle system process 0.429536391751444 1.551993710626291 0.1206637285029963 1.0 0.695346594869622 54 O00443,P10253,P09601,P78417,Q9Y5P4 5 +Detoxification 0.4859919488644207 1.54425951584172 0.1225254758889526 1.0 0.7039826804779363 27 P08183,P00374,P78417,Q6DKJ4 4 +Positive regulation of epithelial cell apoptotic process 0.7976212786665688 1.5422060307062049 0.1230235350606343 1.0 0.7039826804779363 4 Q53EL6 1 +Wound healing spreading of epidermal cells 0.7974809413324448 1.5416517612113538 0.1231582400773252 1.0 0.7039826804779363 4 Q96AC1,Q7Z460,P42345 3 +Regulation of wound healing spreading of epidermal cells 0.7974809413324448 1.5416517612113538 0.1231582400773252 1.0 0.7039826804779363 4 Q96AC1,Q7Z460,P42345 3 +Intrinsic apoptotic signaling pathway in response to dna damage 0.5335611571971473 1.5358416993193922 0.1245772097769817 1.0 0.7095436066259245 19 P46379,Q09472,Q96K76,P09601,Q13315 5 +Regulation of epithelial to mesenchymal transition 0.685250942117338 1.5350895492762693 0.1247618330094426 1.0 0.7099595542093686 7 O00560,Q7Z460,P42345,Q12948 4 +Cell cycle dna replication 0.5490964338307411 1.5326288862323707 0.1253673199903275 1.0 0.7106244159484123 17 O95785,Q14566,Q9BY42,Q15554,O75844 5 +Response to axon injury 0.5490727939914313 1.5324904923253235 0.1254014420151774 1.0 0.7106244159484123 17 P00374 1 +Phosphatidic acid metabolic process 0.717783502632087 1.5322999626982674 0.1254484303223795 1.0 0.7106244159484123 5 Q9NPH0 1 +Sensory perception of light stimulus 0.5897889503248082 1.530536628274688 0.1258839542241214 1.0 0.7106244159484123 12 P50897 1 +Tetrapyrrole catabolic process 0.9729677287159932 1.5270028407791203 0.1267603049757002 1.0 0.7128946449860725 3 P30519 1 +Lysosomal lumen acidification 0.952302086783704 1.526130491107481 0.1269773698220213 1.0 0.7128946449860725 2 P50897 1 +Regulation of chemotaxis 0.4831536274776592 1.526107528665181 0.1269830874210609 1.0 0.7128946449860725 28 Q9BVA1 1 +Myelin assembly 0.6831128880449415 1.52565269302969 0.1270963818182244 1.0 0.7128946449860725 7 Q9NR77,Q16880 2 +Vasculogenesis 0.6556398676393894 1.5250662080591124 0.1272425846595792 1.0 0.7128946449860725 8 O95470,Q4VCS5,Q9Y4G8 3 +Positive regulation of mitochondrion organization 0.5399312101406849 1.5243806738025918 0.1274136449993523 1.0 0.7128946449860725 18 P21796,P42858 2 +Regulation of cholesterol metabolic process 0.7157957948961169 1.5238934678186882 0.1275353254989388 1.0 0.7128946449860725 5 P49748 1 +Cardiac cell development 0.5968715706238491 1.523511536827986 0.1276307765858435 1.0 0.7128946449860725 11 Q9UGN5,Q53EL6,O75844 3 +Regulation of neuron projection regeneration 0.6858444879550354 1.5185413983214726 0.1288779714863661 1.0 0.7139622017037186 6 Q96G23 1 +Regulation of pattern recognition receptor signaling pathway 0.5538595727367993 1.5180506534066596 0.1290016297373655 1.0 0.7139622017037186 16 Q9NPR9,Q9NQC3,O43657,Q9Y4E8,Q9NUD5 5 +Transmembrane transport 0.5156633427720853 1.5171679772518027 0.1292242790735791 1.0 0.7139622017037186 195 P08183,Q14728,P21796,P45880,Q9UBX3,Q99595,O14548,Q15334,Q8WTV0,Q9C0H2,P53985,P00846,O75964,P42858,Q9NS69,Q96ES6,Q9BSK2,O60830,Q8N4V1,Q12955,P00403,Q9BQT8,O43826,P05067,Q9HD20,Q9UHG3,Q70HW3,P78417,O43865,O75844,O14925,Q8IXU6,Q15629,Q8TB61,Q9H2D1,P23786,Q4KMQ2,Q9UDW1,Q9BPX6,P04062,Q9Y6M7,Q96GC9,P21281,P50542,O43772 45 +Nik nf kappab signaling 0.5216912965633529 1.5162548622078675 0.1294549204004527 1.0 0.7139622017037186 20 Q09472,Q99627,P05067,O15111,Q53EL6,O43657 6 +Retrograde axonal transport 0.6262865518871205 1.5145887919837884 0.1298765723094406 1.0 0.7139622017037186 9 P33176,P43034,Q14168 3 +Head morphogenesis 0.6847900542578511 1.5139243815770829 0.1300450194857219 1.0 0.7139622017037186 6 O95470,Q15042 2 +Regulation of tube size 0.5778480605555565 1.5132566484922925 0.130214479851245 1.0 0.7139622017037186 13 Q9HB40,O00443,P48507,P42892 4 +Low density lipoprotein particle clearance 0.6029659761779005 1.513125024479054 0.1302479042076578 1.0 0.7139622017037186 10 Q9H4M9,Q8WTV0,P09601,Q92945 4 +Neuromuscular process controlling balance 0.5777936617868754 1.5129650814571365 0.1302885288006265 1.0 0.7139622017037186 13 P10253,O14773,Q15334,P05067,O43251 5 +Membrane lipid catabolic process 0.6028528070575231 1.5125560048770457 0.1303924765956059 1.0 0.7139622017037186 10 P50897,P04062,P04066,O95470,Q13510,P06280 6 +Calmodulin dependent kinase signaling pathway 0.9483272606823464 1.5103456330936438 0.1309552534102103 1.0 0.7139622017037186 2 O75844 1 +Response to hepatocyte growth factor 0.712436272077404 1.509676870937062 0.1311258958132739 1.0 0.7139622017037186 5 Q15648,P48507 2 +Positive regulation of stem cell differentiation 0.7122249739848087 1.5087823704977663 0.1313544074327146 1.0 0.7139622017037186 5 Q9Y6C9,Q12948 2 +Plasma lipoprotein particle clearance 0.5937998646553734 1.5077461810137651 0.1316195011589438 1.0 0.7139622017037186 11 Q9H4M9,Q8WTV0,P09601,Q92945 4 +Carbohydrate catabolic process 0.4571734452305669 1.50751683077513 0.1316782330303085 1.0 0.7139622017037186 44 P10253,P16278,Q14108,Q9NUJ1,P08236,Q9BRR6 6 +Response to food 0.6832634737446436 1.5072378359039644 0.1317497052499474 1.0 0.7139622017037186 6 P80303 1 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.7875356176816077 1.5023391857270882 0.1330095334638423 1.0 0.7157575072369564 4 Q8TB61 1 +Phosphatidylserine metabolic process 0.7873694822757302 1.5016819483112456 0.1331792680764558 1.0 0.7157575072369564 4 Q8N2K0,Q8NCC3 2 +Negative regulation of vascular associated smooth muscle cell proliferation 0.681385024151903 1.499006633734158 0.1338719111187249 1.0 0.7175173534434105 6 P09601 1 +Nonribosomal peptide biosynthetic process 0.7859541635436832 1.4960822397817677 0.1346322254659648 1.0 0.7194799095579821 4 Q16775,P48507 2 +Amide transport 0.4730927031841023 1.4955070230479226 0.1347821683986487 1.0 0.7194799095579821 35 P08183,P07602,Q9UPY5,Q9NZJ7,O00330,P17858,Q9H2D1,P50416,P22059,P62820,P53985,Q12904,Q9Y5P4 13 +Hypothalamus development 0.7855479389418794 1.4944747968606809 0.135051564525646 1.0 0.7195963597254272 4 O14949,Q15042 2 +Wound healing 0.4194913444041087 1.4935654434897585 0.1352892371967615 1.0 0.7202595205404159 55 Q9BWH2,Q96AY3,Q7Z460,P42785,P09601,P15291,Q16625,Q8WTV0,Q8WUX9,P49257,Q4KMQ2,P38435 12 +Positive regulation of defense response 0.4643609166810252 1.4918244232528983 0.1357451795046902 1.0 0.7206109203212147 40 P09429,Q09472,Q15233,Q15648,Q9BY67,P05067,Q53EL6,Q9NUD5 8 +Response to ketone 0.4725991339013158 1.4917022018038326 0.1357772316562806 1.0 0.7206109203212147 35 Q13126,P04062,P11802,P16278,Q9H7B4 5 +Cytochrome complex assembly 0.5983162032700416 1.4897281881731153 0.1362957197552565 1.0 0.7225944742357853 10 Q9BSK2,O75880,Q9Y2R0,P53701,Q96I36 5 +Negative regulation of cell population proliferation 0.4244229922528955 1.4869198222688935 0.1370359882409018 1.0 0.7235045287872341 90 Q15648,Q13362,P09601,P49711,Q9NR77,Q96TA1,Q96DY7,Q9Y4G8,Q15392,Q13641,Q53EL6,Q96G23 12 +Positive regulation of ion transmembrane transport 0.477954793182708 1.4853041606777866 0.1374632702161691 1.0 0.7245578501369244 26 P08183,Q12955,Q96GC9,P78417,Q4KMQ2,P42858 6 +Regulation of nik nf kappab signaling 0.5404043909202269 1.481651353566181 0.1384330872314141 1.0 0.7269993469424981 17 Q53EL6,O43657,P05067 3 +Microglia differentiation 0.9410400794965228 1.481408195266492 0.1384978322059584 1.0 0.7269993469424981 2 P04062 1 +Water homeostasis 0.6190218017094211 1.4796285805123592 0.1389723948572627 1.0 0.728889015731167 9 P04062 1 +Cardiac epithelial to mesenchymal transition 0.940046372971184 1.477462525770996 0.1395516963779441 1.0 0.7293183852938105 2 Q53EL6 1 +Regulation of systemic arterial blood pressure 0.7047657242826835 1.4771798145286597 0.1396274431449011 1.0 0.7293183852938105 5 P42785 1 +Cellular iron ion homeostasis 0.5954780990685067 1.4754300686237047 0.140096956393493 1.0 0.7311138972121142 10 P09601 1 +Apoptotic cell clearance 0.6445025777482813 1.473730300646624 0.1405542211069654 1.0 0.731157771612849 8 Q8WTV0 1 +Negative regulation of smooth muscle cell proliferation 0.643673251897549 1.4699013674812489 0.1415884691689906 1.0 0.7313981724898051 8 P09601 1 +Vascular associated smooth muscle cell proliferation 0.5860459701208979 1.467876512314339 0.1421377692790502 1.0 0.7313981724898051 11 P09601 1 +Regulation of dna methylation 0.6165478212930563 1.4677057504992186 0.1421841680484594 1.0 0.7313981724898051 9 Q96TA1,O75844 2 +Aminoglycan biosynthetic process 0.6430551521247829 1.4670471094175024 0.1423632405248516 1.0 0.7313981724898051 8 Q8NCH0 1 +Hindbrain morphogenesis 0.615860672485511 1.4643926793893467 0.1430866871802396 1.0 0.7332412397736202 9 P63167,P04062 2 +Protein transport along microtubule 0.7775936360623108 1.4629811402476196 0.1434725396273859 1.0 0.7332412397736202 4 P78559,Q14168,P33176 3 +Vacuole organization 0.4436547642424025 1.4615600521717376 0.1438618080751377 1.0 0.7332412397736202 47 P10253,P50897,P04062,Q96GC9,Q15042,P54802,O14773,Q14108,O75503,Q9NT62,P11117,Q8TBX8,Q96AX1,Q9Y4P8,Q7Z3C6 15 +Maintenance of location 0.4119734800777281 1.4595552897111304 0.1444123347117802 1.0 0.7332412397736202 56 P10253,Q14534,P24390,P04062,Q12955,Q8WTV0,P43034,P78417,P42858 9 +Xenobiotic metabolic process 0.543529283611395 1.458733537685357 0.1446384615667209 1.0 0.7338037420155329 16 P07099,P78417,Q86WA6,O43169 4 +Response to interleukin 4 0.6676093282714642 1.4570666329051192 0.14509798788175 1.0 0.7344139272463562 7 P11802 1 +Regulation of multicellular organism growth 0.5671464767437706 1.4557875468317598 0.145451359372903 1.0 0.7344139272463562 13 P11802,O95470,P05067,O75844 4 +Positive regulation of calcium ion transmembrane transporter activity 0.6134020200988515 1.4525331128834706 0.1463534289414361 1.0 0.7366301542131459 9 P78417,P42858 2 +Hyperosmotic response 0.6664732209233676 1.4520304711941106 0.1464931328195742 1.0 0.7367504434767834 7 Q9BPX6 1 +Steroid hormone biosynthetic process 0.6986588148017283 1.4512729214273232 0.146703878391174 1.0 0.7372275468599127 5 Q9UBM7,Q15648 2 +Negative regulation of neuron projection development 0.519655123418908 1.45021536880541 0.1469984706073164 1.0 0.7381249171300293 19 O14786,Q9NR77,Q86X55,Q9NQC3,P43034,Q96G23 6 +Regulation of plasma lipoprotein particle levels 0.5655287039907835 1.4470812653819256 0.1478741644599108 1.0 0.7383543590158358 13 P09601 1 +Response to oxidative stress 0.4195979153140488 1.4469866154729172 0.1479006722843614 1.0 0.7383543590158358 89 P00374,P30519,Q96T60,Q15165,Q93062,P04062,P00390,P09601,P05067,Q15392,Q99720,O43169 12 +Regulation of lysosomal lumen ph 0.9506295559973492 1.4463156904803016 0.1480886768475646 1.0 0.7383543590158358 3 O75503,P50897 2 +Bone mineralization 0.5893766960933586 1.4446494250558608 0.1485563824247688 1.0 0.7395238917681088 10 O75844 1 +Response to xenobiotic stimulus 0.3986483888179664 1.4437950307621907 0.14879664023306 1.0 0.7395238917681088 70 P08183,P11802,P07099,Q96K76,P09601,O15118,Q86WA6,P78417,O43169 9 +Associative learning 0.5647137887917926 1.442693913603414 0.1491067145314923 1.0 0.7395238917681088 13 Q13641,P50897 2 +Neuronal action potential 0.696612732311486 1.442586705249279 0.1491369307039427 1.0 0.7395238917681088 5 Q12955,P04062 2 +Astrocyte development 0.7722903546569387 1.4419661428000992 0.1493119251551333 1.0 0.7395392480170979 4 P05067,Q00534,P08670 3 +Positive regulation of calcium ion transport 0.5469153957546888 1.4409280864028886 0.1496050003454896 1.0 0.7395392480170979 15 P78417,P42858 2 +Neuron apoptotic process 0.4351565015297331 1.4396230446719855 0.1499740761917003 1.0 0.7407880999468925 49 O95630,O14786,Q15233,P50897,P04062,P09601,Q99720,Q13315,P05067,P48507,Q96A26,Q9UNH7,P55210 13 +Sterol transport 0.5390870400691429 1.4331542771726118 0.1518137529919756 1.0 0.7452462164621521 16 Q8WTV0 1 +Phosphatidylcholine catabolic process 0.9467229524948956 1.432200297507337 0.1520865066233172 1.0 0.7460095259348838 3 Q8NCC3 1 +Regulation of bone mineralization 0.6614549104113912 1.4297700479651798 0.1527830282520526 1.0 0.7477926888943935 7 O75844 1 +Regulation of cellular response to osmotic stress 0.7689174287638135 1.428594020195967 0.153120953869865 1.0 0.7481993152996016 4 Q9BPX6 1 +Formation of extrachromosomal circular dna 0.7679611279483112 1.4248018872439858 0.154214476643365 1.0 0.7523868868137182 4 Q9UQ84 1 +Cellular modified amino acid catabolic process 0.6642163806978351 1.4236130052625346 0.1545585290243341 1.0 0.7528207072223949 6 Q8N2K0,Q9NRN7,Q9UHG3 3 +Anterograde axonal transport 0.5609417981306186 1.4223711724355814 0.1549185272577664 1.0 0.7528207072223949 13 P33176,Q15554,Q92572,Q14168 4 +Carboxylic acid transport 0.4657649756129166 1.4220069048646609 0.1550242464558817 1.0 0.7528207072223949 33 P07602,Q9UBX3,Q9NZJ7,O75915,Q15042,Q9H2D1,Q9BQT8,Q96NB2,P53985 9 +Regulation of regulated secretory pathway 0.5301569316173373 1.421328039988645 0.1552214155229676 1.0 0.7528207072223949 17 P09601 1 +Endocytosis 0.4327438488714277 1.413979157915212 0.1573680221000466 1.0 0.7582781946047598 105 Q8NC96,Q5VW38,O00443,P20645,Q15642,P50897,O15118,Q9Y5X1,Q14108,Q15334,Q8WTV0,P05067,O00560,Q4KMQ2,O15260 15 +Positive regulation of nitric oxide synthase activity 0.941414016683224 1.4130182182533204 0.1576503674693277 1.0 0.7582781946047598 3 P00374 1 +Torc1 signaling 0.6612345854323105 1.4104919922380768 0.1583944592938562 1.0 0.7582781946047598 6 Q96EE3,Q13315,Q9Y4R8,P42345 4 +Glycolipid transport 0.9231533620404108 1.410414559759432 0.158417308713969 1.0 0.7582781946047598 2 P07602 1 +Prostate gland growth 0.9231533620404108 1.410414559759432 0.158417308713969 1.0 0.7582781946047598 2 P07602 1 +Regulation of myotube differentiation 0.7642813737328261 1.4102069553320418 0.1584785826711325 1.0 0.7582781946047598 4 Q96TA1 1 +Positive regulation of vasculature development 0.5501742021362899 1.4100200595273382 0.158533759873332 1.0 0.7582781946047598 14 P09601 1 +Regulation of actin cytoskeleton reorganization 0.6044943818965627 1.4095009582290727 0.1586870903171648 1.0 0.7582781946047598 9 O14786,Q9UQB8 2 +Homologous chromosome segregation 0.5821888268478397 1.4083181652531522 0.159036879094029 1.0 0.7582781946047598 10 P46379,Q13315,Q9BTX1,Q92791 4 +Cerebral cortex neuron differentiation 0.7636357145115309 1.4076456019045414 0.1592360370939891 1.0 0.7582781946047598 4 P50542 1 +Mitochondrial membrane organization 0.4535464641079617 1.4041098335900628 0.1602861458102313 1.0 0.759866214340307 40 P45880,Q13505,P50542,Q9Y512,Q9NS69 5 +P body assembly 0.6289886181121129 1.4019739757773717 0.1609230181131336 1.0 0.7601934037958122 8 Q96F86,P26196,Q9HBH5,Q9NZN8 4 +Tail anchored membrane protein insertion into er membrane 0.6288039560221877 1.401118322877986 0.1611786932584258 1.0 0.7606964736721847 8 P46379,O43681,Q5J8M3,Q8N4V1 4 +Endosome organization 0.4658407118273923 1.3999199696279083 0.1615372852997179 1.0 0.761823728003562 28 Q14108,Q8WUX9,Q2M389 3 +Blood vessel morphogenesis 0.3965200590718656 1.3970960121205724 0.1623847008733931 1.0 0.7626669141365069 72 P35613,Q9NZ08,O00443,Q15648,Q96AY3,P42785,P09601,Q13685,O95470,Q96TA1,Q9Y4G8,Q12948 12 +Regulation of protein neddylation 0.7608473111375311 1.396582368089634 0.1625391954935942 1.0 0.7626669141365069 4 Q96GG9 1 +Pyridine containing compound metabolic process 0.6539708666418472 1.3965290993949675 0.1625552240756214 1.0 0.7626669141365069 7 Q13126,P43490 2 +Cellular oxidant detoxification 0.5022678385216555 1.3932790416447225 0.1635354258327508 1.0 0.7654399501772834 20 P00374,P78417,Q6DKJ4 3 +Regulation of water loss via skin 0.6847454926087939 1.3921520006090622 0.1638763743058147 1.0 0.7654783357809053 5 P04062 1 +Hormone biosynthetic process 0.6266234402455564 1.3910121586445157 0.16422173980013 1.0 0.7665287664038349 8 Q15648 1 +Positive regulation of cellular response to transforming growth factor beta stimulus 0.6840396617099316 1.389149636334743 0.1647872527866241 1.0 0.7665628280283461 5 O00560 1 +Calcium ion transport 0.4196760139348051 1.3882344366769546 0.1650656692716985 1.0 0.7665628280283461 52 Q9BPX6,P21796,P78417,Q4KMQ2,P42858,O75844 6 +Maintenance of dna repeat elements 0.7586997540311454 1.388060169516038 0.1651187238790348 1.0 0.7665628280283461 4 P52701,O75844 2 +Response to gonadotropin 0.916859887379928 1.3854573878234742 0.165912653633319 1.0 0.7665628280283461 2 P16435 1 +Response to follicle stimulating hormone 0.916859887379928 1.3854573878234742 0.165912653633319 1.0 0.7665628280283461 2 P16435 1 +Cellular response to gonadotropin stimulus 0.916859887379928 1.3854573878234742 0.165912653633319 1.0 0.7665628280283461 2 P16435 1 +Cellular response to follicle stimulating hormone stimulus 0.916859887379928 1.3854573878234742 0.165912653633319 1.0 0.7665628280283461 2 P16435 1 +Cotranslational protein targeting to membrane 0.5697979365176742 1.384021626382031 0.1663518328567428 1.0 0.7665628280283461 11 P43307,Q15629 2 +Regulation of triglyceride metabolic process 0.9332990866512764 1.3837012498890364 0.1664499507017294 1.0 0.7665628280283461 3 Q8WTV0 1 +Response to thyroid hormone 0.6550998093196212 1.3834751356755226 0.1665192261628321 1.0 0.7665628280283461 6 Q15648,P04062 2 +Hippocampus development 0.523381144487381 1.3813205039758194 0.1671804365268427 1.0 0.7670983550851191 17 Q9H0D6,Q13144,Q00534,Q15058,P07196,P43034,O14949,P62826 8 +Retinol metabolic process 0.6500392443836942 1.3790477044272027 0.167880046076567 1.0 0.7672169372592945 7 Q9BTZ2,Q6NUM9 2 +Positive regulation of calcium ion transmembrane transport 0.5599884843857657 1.3736711530485162 0.169543796336588 1.0 0.7708787183859206 12 P78417,P42858 2 +Regulation of cation transmembrane transport 0.4387600803293723 1.3721998602363803 0.170001228927588 1.0 0.7714321101550038 45 P21796,Q12955,Q96GC9,Q15334,P05067,P78417,Q4KMQ2,P42858 8 +Homologous chromosome pairing at meiosis 0.6222503117274485 1.370730443381227 0.1704590009530491 1.0 0.7724075242616086 8 P46379,Q9BTX1 2 +Amyloid fibril formation 0.6518766401133641 1.369269995113182 0.1709148934937578 1.0 0.7733716588956526 6 P05067,O15212,Q99471 3 +Organelle disassembly 0.4357223069183547 1.3681492655771454 0.1712653584750154 1.0 0.7744066884278951 46 P33176,Q9H300,P21796,P41214,Q92538,Q9Y3C8,Q9ULC4,P04062,P50851,Q9UII2,P46199,P06493,Q9NT62,P42858,Q9BWH2,Q9Y4P8,Q7Z3C6 17 +Cellular ion homeostasis 0.4000811620845124 1.3645174768365913 0.172404757526996 1.0 0.7763002908087062 78 Q9BPX6,O75880,P50897,Q9Y6M7,Q93050,P09601,O75503,Q15334,P05067,Q9HD20,Q96AX1,P78417,P42858 13 +Vitamin metabolic process 0.461043605722627 1.3643919102061235 0.1724442526375313 1.0 0.7763002908087062 25 P00374,P04062,Q9H2D1,P78417,O00764 5 +T cell differentiation in thymus 0.5949440863143879 1.3632612216798226 0.1728001987264069 1.0 0.7769292327190114 9 O96005,P04062 2 +Regulation of amyloid fibril formation 0.6775724676905911 1.3616287159334737 0.1733150880526333 1.0 0.7773153954928105 5 P05067,O15212,Q99471 3 +Positive regulation of i kappab kinase nf kappab signaling 0.4585563985775412 1.3608268833302457 0.1735684041158778 1.0 0.7773153954928105 32 P29692,Q86UE4,P02786,Q8TB61,P09601,Q9H2U1,P14373,P19474,O15111,P61088,O43657 11 +Mitochondrial respirasome assembly 0.9105664127194448 1.3605173160821844 0.1736662770177723 1.0 0.7773153954928105 2 P14406 1 +Negative regulation of response to external stimulus 0.4442302641515544 1.360153823732139 0.1737812515301322 1.0 0.7773153954928105 42 Q9Y3Z3,P28070,P04062,Q7Z460,P80303,O43657,Q96G23 7 +Insulin receptor signaling pathway 0.4698178146534208 1.3581210644492534 0.1744252722498132 1.0 0.7780306868709399 23 O00443,P43490,P11802,Q8TBX8,Q9UQB8 5 +Positive regulation of excitatory postsynaptic potential 0.9099039417025534 1.3578931904599203 0.1744975784417575 1.0 0.7780306868709399 2 Q9UQB8 1 +Regulation of protein polyubiquitination 0.6193753996454816 1.357388049071619 0.1746579435267334 1.0 0.7780306868709399 8 O75150,Q96FW1,Q13309,Q9Y263 4 +Calcium ion regulated exocytosis 0.5930522342047609 1.354090145273234 0.1757076198271847 1.0 0.7780306868709399 9 Q68EM7,Q15042 2 +3 utr mediated mrna destabilization 0.6481597119739985 1.352880536960868 0.1760937981701467 1.0 0.7780306868709399 6 Q13148,Q9HCE1,Q9H2U1,Q92945 4 +Macrophage differentiation 0.675413667030992 1.3524377724864718 0.1762353128176799 1.0 0.7780306868709399 5 P04062 1 +Positive regulation of phosphoprotein phosphatase activity 0.7495603382581668 1.3517797889518548 0.1764457715299143 1.0 0.7780306868709399 4 Q8IV63 1 +Positive regulation of transporter activity 0.4782719704005534 1.351491148422736 0.1765381534694652 1.0 0.7780306868709399 22 P08183,Q12955,Q96GC9,P78417,P42858 5 +Cochlea development 0.6750663129973578 1.35095875913803 0.1767086439016907 1.0 0.7780306868709399 5 P43034,P49736,Q13308,Q9BW83 4 +Fatty acyl coa metabolic process 0.5307983496263362 1.3498296407391448 0.1770706347290511 1.0 0.7780306868709399 15 Q9NZ01 1 +Response to corticosteroid 0.4587750981099504 1.3471638594112545 0.1779274648057511 1.0 0.7780306868709399 27 P16278,Q9H7B4,P04062 3 +Plasma membrane phospholipid scrambling 0.9231278992710412 1.346969408594468 0.1779900853653013 1.0 0.7780306868709399 3 Q4KMQ2,Q7Z3C6 2 +Regulation of transcription regulatory region dna binding 0.5468763080833023 1.3463881395667538 0.178177373918118 1.0 0.7780306868709399 13 Q96TA1,Q09472,O75844 3 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.4581921724414765 1.3458628484584574 0.1783467521605206 1.0 0.7780306868709399 24 P24390,Q9Y282 2 +Regulation of endoplasmic reticulum tubular network organization 0.7479483136958418 1.3453790409171067 0.1785028601452629 1.0 0.7780306868709399 4 Q15042 1 +Ketone catabolic process 0.747939148817418 1.345342649636044 0.1785146064647937 1.0 0.7780306868709399 4 Q16775,Q6YP21 2 +Sulfur compound transport 0.5696705914191611 1.3448853961662226 0.178662247023559 1.0 0.7780306868709399 10 Q70HW3,Q8TB61 2 +Regulation of skeletal muscle tissue development 0.646317906348366 1.3447562470080432 0.1787039638737368 1.0 0.7780306868709399 6 P16989,Q96TA1 2 +Positive regulation of potassium ion transport 0.6421378979431214 1.3438810390311455 0.1789868583385194 1.0 0.7780306868709399 7 Q4KMQ2,Q9Y3S1 2 +Production of molecular mediator involved in inflammatory response 0.56932598275849 1.3431366396744548 0.1792277333864698 1.0 0.7780306868709399 10 Q53EL6 1 +Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.5278203246062677 1.332948530265144 0.1825486949947627 1.0 0.7847714483906746 15 O00560,Q93062 2 +Glycolipid biosynthetic process 0.5595290485570021 1.3308397719015812 0.1832417382231617 1.0 0.785568691762638 11 Q16880,Q16739,Q8NBX0,Q99805 4 +Somatic diversification of immune receptors via somatic mutation 0.6689983435213995 1.3251146598446062 0.1851331245561076 1.0 0.7900103977034263 5 Q9Y3Z3,Q9UQ84 2 +Cellular carbohydrate metabolic process 0.3861288003083346 1.3245562423259134 0.1853183773035223 1.0 0.7900103977034263 59 P10253,P16278,Q14108,Q9NUJ1,Q9Y223,O75844,Q7LGA3 7 +Cellular response to toxic substance 0.4552337864065198 1.3215369259615717 0.1863223986041822 1.0 0.7900103977034263 26 P00374,P78417,Q6DKJ4 3 +Cell killing 0.4908651956181926 1.32068258074061 0.1866072246225321 1.0 0.7900103977034263 20 P07437,P68371 2 +Embryonic appendage morphogenesis 0.5859955357197759 1.319852596654409 0.1868842369318462 1.0 0.7900103977034263 9 Q15648 1 +Positive regulation of protein neddylation 0.8999668764491562 1.3185620529008295 0.1873155670096644 1.0 0.7900103977034263 2 Q96GG9 1 +Lymphocyte mediated immunity 0.4536964546113393 1.3153592052026586 0.1883892090360566 1.0 0.7900103977034263 30 P33176,Q9UQ84,Q9BY67,P02786,Q9NQT5,P07437,P52701,P09429,P68371 9 +Signal peptide processing 0.6396199584522773 1.3151964720681026 0.1884438805278381 1.0 0.7900103977034263 6 O75503,Q8TCT9,P67812 3 +Calcium ion transmembrane transport 0.4442435454608429 1.3144585233130786 0.1886919471565153 1.0 0.7902950413494081 39 Q9BPX6,P21796,P78417,Q4KMQ2,P42858 5 +Intermembrane lipid transfer 0.7397871394393125 1.3129704169317429 0.1891929168291026 1.0 0.7908313645642254 4 P48739,Q9Y5P4 2 +Myotube differentiation 0.5320758251296117 1.3098900432568246 0.1902330359234636 1.0 0.7915386360661057 14 Q9H4M9,Q96TA1,Q9H7B4,Q8IV08 4 +Antigen processing and presentation 0.4624786945590945 1.3073004830445516 0.1911106802382445 1.0 0.7931155562137714 23 Q9NZ08,Q9UIQ6 2 +Response to testosterone 0.5833134563019353 1.3068288269963255 0.1912708524654398 1.0 0.7932628183736169 9 Q13126 1 +3 phosphoadenosine 5 phosphosulfate biosynthetic process 0.8963232858562469 1.3041569614847268 0.192180070756295 1.0 0.7951427729554619 2 Q8TB61 1 +Positive regulation of epithelial to mesenchymal transition 0.635418018138573 1.2966421205329113 0.1947543527276165 1.0 0.8014406158170093 6 O00560,P42345,Q12948 3 +Positive regulation of blood vessel endothelial cell migration 0.6059253520940999 1.294884769248607 0.1953599833610939 1.0 0.8023968381751756 8 O00443,P09601 2 +Alcohol metabolic process 0.3909166195450788 1.2897999282190669 0.1971201328855791 1.0 0.8043945285436788 76 P00374,Q14534,P04062,P35270,O15118,P16435,Q15800,Q16850,Q8WTV0,P05067,Q15392,P49748,Q14739,Q13510 14 +Nucleobase catabolic process 0.7338033763235183 1.289207869641766 0.1973258298588969 1.0 0.8043945285436788 4 Q02252 1 +Pyrimidine nucleobase catabolic process 0.7338033763235183 1.289207869641766 0.1973258298588969 1.0 0.8043945285436788 4 Q02252 1 +Cation transmembrane transport 0.4267442205522207 1.2890844474455447 0.1973687298108586 1.0 0.8043945285436788 111 P21796,O14548,Q15334,P00846,O75964,P42858,Q96ES6,Q8N4V1,Q12955,P00403,P05067,Q9HD20,Q70HW3,P78417,Q4KMQ2,Q9UDW1,Q9BPX6,Q9Y6M7,Q96GC9,P21281,O43772 21 +Regulation of oxidative phosphorylation 0.5789304058868945 1.28553410154645 0.1986057079781196 1.0 0.8072818325627279 9 P14406,O14548 2 +Mononuclear cell differentiation 0.4402685739282276 1.2823175788430108 0.1997312638428514 1.0 0.8072818325627279 39 Q15648,Q09472,O96005,P24390,P04062,Q13315,Q00534,P09429,O00625 9 +Regulation of ruffle assembly 0.6282754073734571 1.2820938389379746 0.1998097299792081 1.0 0.8072818325627279 7 P35241,P35080,Q9P258,P07737 4 +Fatty acid derivative biosynthetic process 0.5267929500532023 1.280576913466707 0.2003423133151995 1.0 0.8078074252886287 14 Q9NZ01 1 +Dna templated transcription termination 0.6027069183779237 1.279911943557832 0.2005761066523552 1.0 0.8078171938114644 8 O75844,Q16637 2 +Regulation of synaptic vesicle exocytosis 0.5776226618545611 1.2791780523267868 0.2008343627687749 1.0 0.8078171938114644 9 Q15042,P35080,P16615,Q06787 4 +Regulation of atp metabolic process 0.4490275516972321 1.2780235953990309 0.2012411067583068 1.0 0.8078171938114644 25 Q9BSK2,P14406,O14548,P00403,P05067 5 +Ion homeostasis 0.4118997742815505 1.2779327871408672 0.2012731262473273 1.0 0.8078171938114644 97 Q9BPX6,P30519,O75880,P50897,Q9Y6M7,Q93050,P09601,O75503,Q15334,P05067,Q9HD20,Q9Y487,Q96AX1,P78417,P48507,P42858 16 +Endocrine process 0.6311609206754096 1.277837990883833 0.201306555890937 1.0 0.8078171938114644 6 P42892 1 +Stress activated protein kinase signaling cascade 0.4449453326035708 1.277275346669598 0.2015050542070051 1.0 0.8078171938114644 35 Q96J02,P09429,Q96KB5,Q99873,O75915,P31689,P05067,P29372,P78318,P43034,O00560,Q53EL6,O75844 13 +Inorganic ion transmembrane transport 0.4195482702634411 1.2745149563273936 0.2024809755626628 1.0 0.8087240634048407 105 P21796,Q9UBX3,O14548,P00846,O75964,P42858,Q96ES6,Q8N4V1,P00403,O43826,Q9HD20,Q9UHG3,P78417,Q4KMQ2,Q9UDW1,Q9BPX6,Q9Y6M7,Q96GC9,P21281 19 +Leukocyte mediated immunity 0.4318818230020124 1.2742870973343765 0.2025616875128604 1.0 0.8087240634048407 43 Q9UQ84,P07437,P68371,P09601 4 +Regulation of reactive oxygen species metabolic process 0.4486377185493121 1.2732335956372418 0.2029351624166027 1.0 0.8094504722849067 27 P00374 1 +Mismatch repair 0.540557541331916 1.2707035076821385 0.2038341472465257 1.0 0.8104955279889978 12 Q9UQ84,P43246,P12004,P52701,P09429,P35244,P15927 7 +Mitochondrion endoplasmic reticulum membrane tethering 0.7287443819414752 1.269120117392667 0.2043982262312655 1.0 0.8113444132482401 4 Q96GC9,O43865 2 +Positive regulation of protein polymerization 0.44767599501212 1.2680081453797192 0.2047950417591053 1.0 0.8113969026000538 29 P50552,Q7Z460,Q9Y5X1,P07737,Q16625,Q9UQB8 6 +Regulation of phagocytosis 0.5320375814870807 1.2659424307524356 0.2055336938871002 1.0 0.8113969026000538 13 P09429,Q8WTV0,Q4KMQ2 3 +Bone development 0.4475134687830029 1.2650215956771274 0.2058635865226197 1.0 0.8113969026000538 27 Q15648,Q09472,P16435,P43034,O75844,Q7Z3C6 6 +Positive regulation of toll like receptor 9 signaling pathway 0.8863862206028505 1.26492372692371 0.2058986709743226 1.0 0.8113969026000538 2 Q9NQC3 1 +Toll like receptor 9 signaling pathway 0.8863862206028505 1.26492372692371 0.2058986709743226 1.0 0.8113969026000538 2 Q9NQC3 1 +Regulation of toll like receptor 9 signaling pathway 0.8863862206028505 1.26492372692371 0.2058986709743226 1.0 0.8113969026000538 2 Q9NQC3 1 +Muscle cell apoptotic process 0.531760601312136 1.2644386045954528 0.2060726440430951 1.0 0.8113969026000538 13 P09601 1 +Response to nitrosative stress 0.6545826404359185 1.2636811137605344 0.206344506546432 1.0 0.8113969026000538 5 Q13315,P48507 2 +Intrinsic apoptotic signaling pathway 0.3818425607334605 1.2634682136508304 0.2064209629943372 1.0 0.8113969026000538 70 P46379,Q15233,Q09472,P45880,P16989,Q96K76,O75915,P09601,Q13315,P52701,P31689,P63241,Q8WUK0 13 +Cellular response to biotic stimulus 0.4440087194464016 1.2623583670517016 0.2068198630004318 1.0 0.8113969026000538 34 Q53EL6,Q8WTV0,O75844 3 +Appendage morphogenesis 0.5460992935546867 1.2611213442008238 0.2072651316462599 1.0 0.8113969026000538 11 Q15648 1 +Regulation of hormone metabolic process 0.6270065700846253 1.2594831285501755 0.2078558803727068 1.0 0.8113969026000538 6 O75844,P16435 2 +Vacuolar localization 0.5222710859245436 1.255461881239322 0.2093111375214329 1.0 0.8113969026000538 14 P09601 1 +Protein k48 linked deubiquitination 0.5519574768635617 1.254858265668106 0.2095302166045813 1.0 0.8113969026000538 10 O94966,Q96FW1,Q9Y4E8 3 +Animal organ regeneration 0.5140614788471723 1.2547960440874388 0.2095528090358094 1.0 0.8113969026000538 15 P09601 1 +Bone morphogenesis 0.5725402289186079 1.2544664582504257 0.209672509882818 1.0 0.8113969026000538 9 Q7Z3C6,O75844,P16435 3 +Regulation of synapse structure or activity 0.4418511280068914 1.253159220358406 0.2101477675341976 1.0 0.812020405574211 35 Q13641,P07437,P50897,Q9UQB8 4 +Negative regulation of neuron apoptotic process 0.4453039885673427 1.2488760714361706 0.2117104048371667 1.0 0.8148225018596823 27 O95630,O14786,Q15233,P50897,P04062,P09601,P48681,P43246,P48507,Q9UNH7 10 +Regulation of tor signaling 0.5357857347318925 1.2453598471593346 0.2129995058633436 1.0 0.8174599789959532 12 P04062,Q9Y4R8,Q9P2J5,Q13315,P54646,Q96EE3,O75844 7 +Cell morphogenesis involved in neuron differentiation 0.402308749216292 1.2411564596755416 0.2145479557773046 1.0 0.8202849126533729 91 P43034,Q9BVA1,Q12955,P42892,Q15334,Q96TA1,P05067,P83731,Q9Y4G8,Q9NQC3,Q9UQB8,Q13641,Q13509,O43251 14 +Branched chain amino acid biosynthetic process 0.8800927459423683 1.2401223905320982 0.2149301284397884 1.0 0.8203103039003464 2 O15382 1 +Transmission of nerve impulse 0.61859010209669 1.238879977725523 0.2153899496170586 1.0 0.8203103039003464 7 Q12955,P43034,P04062 3 +Axonal transport 0.485193117802365 1.2362157619367629 0.2163783733345399 1.0 0.8203103039003464 19 P33176,Q92572,Q14168,P43034,Q15554 5 +Negative regulation of lipid metabolic process 0.6174732459046609 1.2338954232219357 0.2172418752005804 1.0 0.8203103039003464 7 Q8TBX8,P49748 2 +Diencephalon development 0.6474193800264748 1.2331489559104023 0.2175201953284948 1.0 0.8203103039003464 5 O14949,Q15042 2 +Leukocyte differentiation 0.3997961075687297 1.2321033563633268 0.2179104778065919 1.0 0.8209262818869693 53 P09429,Q09472,O96005,P24390,Q15648,P04062,Q13315,Q00534,P05067,P43034,Q14739,O00625 12 +Nucleoside bisphosphate biosynthetic process 0.4424732689763074 1.2294112703650335 0.2189176467591211 1.0 0.8209262818869693 29 P50897,Q9NZ01 2 +Negative regulation of phagocytosis 0.6457801284368097 1.226162535989421 0.2201375164329619 1.0 0.8209262818869693 5 P63244,P09429,Q9NT62 3 +Carbohydrate homeostasis 0.4382639252481298 1.2251789054065456 0.2205078205894368 1.0 0.8209262818869693 35 P49366,Q15120,Q99808,P42785,P48507,P53985,Q96RR1 7 +Extracellular exosome assembly 0.7175815198886084 1.2248145105368566 0.2206451164645368 1.0 0.8209262818869693 4 O00560 1 +Acylglycerol homeostasis 0.8891469389200806 1.2245139165819043 0.2207584197084069 1.0 0.8209262818869693 3 Q8WTV0 1 +Cellular copper ion homeostasis 0.8889204185853197 1.2236996949603332 0.2210655347840173 1.0 0.8209262818869693 3 P05067 1 +Copper ion homeostasis 0.8889204185853197 1.2236996949603332 0.2210655347840173 1.0 0.8209262818869693 3 P05067 1 +Glycosylceramide biosynthetic process 0.8757866843325638 1.223176659826945 0.2212629791403437 1.0 0.8209262818869693 2 Q16739 1 +Response to cisplatin 0.8751242133156723 1.2205714448848752 0.2222483234657151 1.0 0.8209262818869693 2 P09601 1 +Negative regulation of immune response 0.4896803904005026 1.2203635098175911 0.2223271038528018 1.0 0.8209262818869693 18 Q9Y3Z3,P09601,P28070 3 +Positive regulation of cholesterol storage 0.8747929778072255 1.219269025149878 0.2227421010294212 1.0 0.8209262818869693 2 Q8WTV0 1 +Pyridine containing compound biosynthetic process 0.7160549523360518 1.2187585387769384 0.2229358523135585 1.0 0.8209262818869693 4 P43490 1 +Muscle cell development 0.4410294648561893 1.2185285410212563 0.2230231856421438 1.0 0.8209262818869693 26 Q9UGN5,Q16527,Q13045,Q96TA1,Q9H7B4,O75844 6 +Membrane raft organization 0.5651155900348658 1.218345412768568 0.223092739477102 1.0 0.8209262818869693 9 O15118 1 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6173945991515609 1.2170062859387645 0.2236018242279862 1.0 0.8209262818869693 6 O43657,Q9Y4E8 2 +Immune effector process 0.3758188223683635 1.2166133798249137 0.2237513496242418 1.0 0.8209262818869693 59 Q9UQ84,Q9BY67,P09601,P07437,P68371 5 +Telomerase holoenzyme complex assembly 0.7153427514202423 1.2159335126742563 0.2240102505651395 1.0 0.8209262818869693 4 Q13315,Q15185 2 +Positive regulation of t cell proliferation 0.5888327050647848 1.215319403882838 0.2242442940448912 1.0 0.8209262818869693 8 P09429,P49366,P23396,P02786 4 +Limbic system development 0.4664250474111347 1.215134303418469 0.2243148720972767 1.0 0.8209262818869693 21 Q9H0D6,O14786,Q15042,Q13144,Q00534,P43034,O14949,P62826 8 +Monocyte differentiation 0.613223730105469 1.214928405037647 0.2243933989628166 1.0 0.8209262818869693 7 O00625,Q15648 2 +Glial cell proliferation 0.6423720544120619 1.2116389354871182 0.2256506235072688 1.0 0.8235590590848598 5 Q96G23 1 +Dendrite development 0.4124293021166594 1.209330016219281 0.2265360834879664 1.0 0.8246750103955625 48 P43034,O14786,Q9Y296,P78559,P46821,Q86X55,Q15334,P05067,Q9Y4G8,Q9UQB8,Q13641,O60678,O43251 13 +Negative regulation of muscle organ development 0.713354626425508 1.2080485074198084 0.227028604550074 1.0 0.8248749184166595 4 P16989 1 +Negative regulation of muscle tissue development 0.713354626425508 1.2080485074198084 0.227028604550074 1.0 0.8248749184166595 4 P16989 1 +Pore complex assembly 0.5209152487886499 1.205507641930376 0.2280073896955463 1.0 0.8272133342014375 13 Q9BTX1,Q9NQC3 2 +Regulation of biomineralization 0.5624484529442667 1.2053653956058417 0.228062274157391 1.0 0.8272133342014375 9 P04920,Q4KMQ2,O75844 3 +Positive regulation of rig i signaling pathway 0.8836123817213577 1.204630637077867 0.2283459239803715 1.0 0.8272988430313918 3 Q9Y4E8 1 +Sprouting angiogenesis 0.5050463458573717 1.2034756785340672 0.2287922976379115 1.0 0.8284442786410889 15 P09601 1 +Cardiac ventricle development 0.5275771491749198 1.2017276656976157 0.2294690586585255 1.0 0.8290381023567194 12 Q15648,O75844 2 +Positive regulation of protein polyubiquitination 0.7115905535842724 1.20105357717101 0.2297304190827707 1.0 0.8290381023567194 4 O75150,Q13309 2 +Vacuolar acidification 0.6100186083134312 1.200622256905969 0.2298977634364982 1.0 0.8290381023567194 7 Q93050,O75503,P50897 3 +Ether metabolic process 0.5614204379047891 1.20036199572715 0.2299987819332929 1.0 0.8290381023567194 9 P43034,P07099,Q6PIU2 3 +Transepithelial transport 0.8818801250495749 1.1984121225582398 0.2307566154039966 1.0 0.830358363801033 3 P08183 1 +Srp dependent cotranslational protein targeting to membrane 0.5850032394368615 1.1974832948404248 0.2311182349130724 1.0 0.830719892947439 8 Q15629 1 +Metal ion transport 0.3960250713891217 1.1962269763919802 0.2316079963575827 1.0 0.8315406731529016 89 Q9BPX6,P21796,Q8N4V1,Q9Y6M7,Q9HD20,O43865,P78417,Q4KMQ2,O15173,P42858,O75844 11 +Negative regulation of response to wounding 0.6082372875645347 1.1926713787398506 0.2329980990422697 1.0 0.8316005771822255 7 Q96G23 1 +Walking behavior 0.8802784559025627 1.1926645236001718 0.2330007848430226 1.0 0.8316005771822255 3 O15118 1 +Cellular monovalent inorganic cation homeostasis 0.4363487643930991 1.1895971880293403 0.2342047516122782 1.0 0.8316005771822255 24 P50897,Q9Y6M7,Q93050,O75503,Q96AX1 5 +Layer formation in cerebral cortex 0.7084118378587088 1.1884531256410271 0.234654936771836 1.0 0.8316005771822255 4 Q96N66 1 +Er associated misfolded protein catabolic process 0.6065877648805093 1.185308990361857 0.2358953001630799 1.0 0.8325361496968757 7 P46379,Q9BUN8,Q9HCN8 3 +Negative regulation of extrinsic apoptotic signaling pathway 0.4696682152108075 1.1851656631561225 0.2359519531694773 1.0 0.8325361496968757 20 O14786,Q86WB0,P09601,Q8IWB1,P48507,P26583,P42858 7 +Phosphatidylinositol 3 phosphate biosynthetic process 0.7065251485497446 1.1809768262086178 0.2376119293808831 1.0 0.8325361496968757 4 O00443 1 +Regulation of response to biotic stimulus 0.372109870896943 1.1777012648912455 0.2389157224726033 1.0 0.8334679915162704 59 Q9NZ08,Q9Y3Z3,Q15233,Q09472,Q15648,Q9BY67,P09429,O43657,Q9Y4E8,Q9NUD5,O75844 11 +Glycosphingolipid biosynthetic process 0.876076872100731 1.177597302272826 0.2389571858732595 1.0 0.8334679915162704 3 Q16739,Q99805 2 +Regulation of muscle cell differentiation 0.4824637490826596 1.1763920929440836 0.2394382299777417 1.0 0.8337745041698923 18 Q9UGN5,Q96TA1,Q53EL6,P42345 4 +Intraciliary transport 0.6338808669002483 1.1754671844705882 0.2398078583821059 1.0 0.8345663166468543 5 Q8NCM8,Q9BW83 2 +C terminal protein amino acid modification 0.863530970520044 1.1750665875967583 0.2399680768234766 1.0 0.8345663166468543 2 O60725 1 +Dsrna processing 0.5070545742076302 1.170824176928206 0.2416694576221152 1.0 0.8387894650255849 14 Q9UPY3,Q15631,O75844 3 +Lipid droplet organization 0.6027187959867331 1.1680418975941056 0.2427898651101192 1.0 0.841301264613605 7 Q14534 1 +Regulation of long term synaptic potentiation 0.6318011757026049 1.166612031035612 0.2433670825035541 1.0 0.84207652561777 5 P05067 1 +Protein destabilization 0.5203222300150439 1.163140290593707 0.2447725874463091 1.0 0.8436026998912911 12 Q96AB3,Q9BUN8,Q09472,P42858 4 +Positive regulation of transmembrane transport 0.4328664830243843 1.1621694427799525 0.245166644307333 1.0 0.8436026998912911 31 P08183,Q12955,Q96GC9,Q9Y3S1,P78417,Q4KMQ2,P42858 7 +Lipid storage 0.5054168250401914 1.1617070076839284 0.245354498228369 1.0 0.8436026998912911 14 Q8WTV0,Q14534,P04062 3 +Response to auditory stimulus 0.8598873799271316 1.1608018593572205 0.2457224866801888 1.0 0.8436026998912911 2 P42858 1 +Fertilization 0.4332132568861239 1.1606227110267864 0.2457953653694322 1.0 0.8436026998912911 29 P45880 1 +Regulation of heart contraction 0.4499160349999211 1.1601851361979083 0.2459734373307678 1.0 0.8436026998912911 22 P78417,O75844 2 +Negative regulation of receptor internalization 0.6300992580980778 1.159366938578352 0.2463066471317776 1.0 0.8438356968510335 5 O00560 1 +Sterol biosynthetic process 0.4409974138506435 1.1580167372061732 0.2468572062336025 1.0 0.844666979352723 23 Q14534,P16435,Q15800,Q16850,Q15392 5 +Organic acid transport 0.4159521717689556 1.1567485408348874 0.2473751115162492 1.0 0.844666979352723 44 P08183,Q9UBX3,O75915,Q15042,Q9H2D1,Q9BQT8,Q96NB2,P23786,P53985,O43772 10 +Regulation of neuron projection development 0.3684191441184337 1.1547809683454884 0.2481801325778549 1.0 0.8461216323744492 67 Q09472,Q14108,Q9NR77,P10586,Q9Y4G8,Q9NQC3,Q9UQB8,Q96G23 8 +Calcium mediated signaling 0.4851837267825561 1.15447898587847 0.2483038490479561 1.0 0.8461216323744492 17 P78417,O75844 2 +Disaccharide metabolic process 0.8578999668764535 1.1530292004204346 0.2488983993275346 1.0 0.8465634999242477 2 P10253 1 +Prostate gland development 0.627160282939991 1.1468592965579023 0.2514397775159049 1.0 0.8474344825022248 5 P07602 1 +Chemical homeostasis 0.4555919120561778 1.145853936615027 0.2518555935026627 1.0 0.8474344825022248 160 P30519,P42785,P09601,O75503,Q15334,Q8WTV0,Q9Y487,Q96AX1,P53985,P42858,Q12955,O15118,P05067,Q9HD20,Q9NQC3,P78417,Q9Y5P4,P49366,O75880,P50897,Q99808,Q93050,P09429,Q96CP7,O15260,Q9BPX6,P04062,P28340,Q9Y6M7,Q9Y3S1,Q16739,Q9BWH2,Q9H4M9,P48507 34 +Thioester biosynthetic process 0.4391762751757603 1.1453374968499923 0.2520693788663033 1.0 0.8474344825022248 23 Q9NZ01 1 +Modification of postsynaptic actin cytoskeleton 0.6262800730667286 1.1431142854972045 0.2529911438115286 1.0 0.8474344825022248 5 Q9UQB8 1 +Positive regulation of locomotion 0.3783007169984562 1.1426493475395414 0.2531842080932092 1.0 0.8474344825022248 77 O00443,Q7Z460,P09601,Q8WTV0,P05067,Q9Y4G8,Q9NQC3,Q13641,O00560,Q4KMQ2 10 +Glutamate receptor signaling pathway 0.6963871395425845 1.1408421674658902 0.2539356094510974 1.0 0.8474344825022248 4 P05067,Q92542,Q06787 3 +Cholesterol storage 0.8658017259810566 1.140818234015324 0.2539455710636322 1.0 0.8474344825022248 3 Q8WTV0 1 +Aspartate family amino acid biosynthetic process 0.522959415737717 1.140739557894118 0.25397831965982 1.0 0.8474344825022248 11 Q13126 1 +Bicarbonate transport 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.8474344825022248 2 Q9Y6M7 1 +Response to increased oxygen levels 0.5724914812386446 1.139212275118234 0.2546146269474958 1.0 0.8474344825022248 8 P00846 1 +Cellular component assembly involved in morphogenesis 0.4624484775502663 1.1389060841722558 0.2547423276998959 1.0 0.8474344825022248 20 Q16880,Q7Z460,Q9NR77,Q13045,P43034,Q16527 6 +Retinoic acid metabolic process 0.8539251407750962 1.137501877188497 0.255328540297814 1.0 0.8474344825022248 2 Q9HB40 1 +Digestion 0.5154741340342043 1.1373488766434037 0.255392469860082 1.0 0.8474344825022248 12 Q16739,Q8WTV0 2 +Chloride transmembrane transport 0.6249189095650804 1.1373239200471166 0.2554028987493915 1.0 0.8474344825022248 5 Q9UHG3 1 +Protein polymerization 0.3755693830827623 1.136613857535007 0.255699744467994 1.0 0.8474344825022248 75 P45880,P52907,Q9Y5X1,P07900,Q14019,Q13045,P63000,O15145,Q9BSJ2,P47755,P50552,P04350,Q7Z460,P46821,P07737,Q16625,Q9UQB8,P42345,Q6IBS0,Q96S59,P35611 21 +Base excision repair gap filling 0.5287049077578203 1.1364243069074147 0.2557790277263549 1.0 0.8474344825022248 10 Q96T60,Q07864,P12004,P28340 4 +Very long chain fatty acid metabolic process 0.528508675040163 1.1354246004461257 0.2561974571248597 1.0 0.8474344825022248 10 Q9NZ01 1 +Androgen metabolic process 0.624451897004752 1.1353375325205006 0.2562339220970107 1.0 0.8474344825022248 5 Q15648 1 +Dna methylation 0.4755695666230267 1.134356282398066 0.2566451293288279 1.0 0.8474344825022248 18 Q8NB78,Q96TA1,O75844 3 +Regulation of ph 0.4613404311403978 1.1318043387755206 0.2577167032296152 1.0 0.8474344825022248 20 P50897,Q9Y6M7,Q93050,O75503,Q96AX1 5 +Regulation of cellular ph 0.4613404311403978 1.1318043387755206 0.2577167032296152 1.0 0.8474344825022248 20 P50897,Q9Y6M7,Q93050,O75503,Q96AX1 5 +Positive regulation of nucleotide metabolic process 0.5981014878425803 1.131780138478711 0.2577268798880543 1.0 0.8474344825022248 6 P00403 1 +Positive regulation of atp metabolic process 0.5981014878425803 1.131780138478711 0.2577268798880543 1.0 0.8474344825022248 6 P00403 1 +Dna dependent dna replication maintenance of fidelity 0.506596691202338 1.127616889742581 0.2594817506181235 1.0 0.8474344825022248 13 Q7Z7L1,Q9Y3Z3,Q8NFC6,P28340,P12004,Q9UNS1 6 +Formation of translation preinitiation complex 0.5699855407829307 1.1275454169708192 0.2595119495205842 1.0 0.8474344825022248 8 P55010,P41214,Q9ULC4 3 +Regulation of calcium ion transmembrane transporter activity 0.4987040382827356 1.124331196632689 0.2608725485260081 1.0 0.8474344825022248 14 P78417,P42858 2 +Cellular response to carbohydrate stimulus 0.4737991987074691 1.1235593753522848 0.261199998460659 1.0 0.8474344825022248 18 Q15120,Q99808,O00330,P22059,P55809,P63244,Q96RR1,P48507,P54646 9 +Epiboly 0.5959116000191985 1.1221153939612574 0.2618133794175885 1.0 0.8474344825022248 6 Q96AC1,Q7Z460,P42345 3 +Rescue of stalled ribosome 0.5955384920306774 1.120469014067372 0.2625139497233539 1.0 0.8474344825022248 6 P63244,O94822,O60524 3 +Dicarboxylic acid transport 0.4794429802783719 1.1202779748671392 0.262595324789062 1.0 0.8474344825022248 17 Q9UBX3,O75915,Q15042,Q9H2D1,Q9BQT8 5 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.524982607684681 1.11746256641483 0.2637965964808941 1.0 0.8474344825022248 10 P46379 1 +Modification of postsynaptic structure 0.5911196526570088 1.116300815155479 0.2642933928180118 1.0 0.8474344825022248 7 Q9UQB8 1 +Regulation of actin filament organization 0.3601905862961704 1.1144486411044925 0.2650867659800366 1.0 0.8474344825022248 63 P63167,P52907,Q9Y5X1,Q14019,Q13045,P63000,O15145,Q96AC1,P35080,P47755,O14786,P50552,Q9NUQ9,Q7Z460,P07737,Q9UQB8,Q14247,P42345,Q6IBS0,P35241,O75083,Q9UEY8,Q9Y281,P14373,P35611 25 +Mammary gland epithelial cell proliferation 0.6192501967978018 1.1132230944072796 0.265612626391003 1.0 0.8474344825022248 5 Q15648 1 +Positive regulation of nf kappab transcription factor activity 0.4265412449750031 1.1131862315217145 0.265628454724133 1.0 0.8474344825022248 26 Q09472,Q86UE4,P60900,P02786,P14373,P19474,P05067,O15111,P61088,Q96HY6,Q92974 11 +Positive regulation of glial cell differentiation 0.5938048442887973 1.112820235799019 0.2657856426699228 1.0 0.8474344825022248 6 Q9UPY3,P42345 2 +Membrane depolarization 0.5431719048028999 1.1115467224475817 0.2663330906240211 1.0 0.8474344825022248 9 Q12955,Q9UII2,P48507,P63244 4 +Ph reduction 0.5237003739426983 1.1109316813258785 0.2665977573771549 1.0 0.8474344825022248 10 Q93050,O75503,P50897 3 +Face development 0.5428849019460582 1.1101504692885686 0.2669341922275925 1.0 0.8474344825022248 9 O95470,Q15042 2 +Establishment of centrosome localization 0.6885932772785341 1.110041828012424 0.2669810025305861 1.0 0.8474344825022248 4 P43034 1 +Inorganic ion import across plasma membrane 0.593127609186053 1.1098328323447857 0.2670710684402642 1.0 0.8474344825022248 6 P05026,P05023,Q9Y3S1,P23634 4 +Antigen processing and presentation of peptide antigen 0.5168454967040701 1.1089216019846106 0.2674640039420572 1.0 0.8477198829198422 11 Q9UIQ6 1 +Positive regulation of protein binding 0.4339241812439328 1.1087632320536769 0.2675323358291741 1.0 0.8477198829198422 23 O14786,Q09472,Q9BUN8,P35611,P05067,Q9Y4G8,P62826 7 +Response to epidermal growth factor 0.4883913583238846 1.108537297434992 0.267629840628695 1.0 0.8477198829198422 15 Q15648,Q9UQB8 2 +Autophagy of nucleus 0.8565275016567266 1.1077171384947726 0.2679839953343026 1.0 0.8482160091128524 3 Q9Y4P8,Q7Z3C6 2 +Substrate dependent cell migration cell extension 0.6875626757697265 1.1059731886780442 0.2687381243012265 1.0 0.8497574288292263 4 O00560,O14786 2 +Astrocyte differentiation 0.541528407513986 1.1035516984461031 0.2697876536472954 1.0 0.8509150480291452 9 Q13144,P05067,Q00534,P08670 4 +Mitochondrial electron transport ubiquinol to cytochrome c 0.6867753688930633 1.102865743349073 0.2700854726951296 1.0 0.8509150480291452 4 O14949 1 +Connective tissue development 0.4414075375143511 1.102621647009502 0.27019150563517 1.0 0.8509150480291452 22 P11802,O15173,P43490,O75844 4 +Positive regulation of biomineralization 0.686267183683654 1.100860303525938 0.2709574612519125 1.0 0.8512747498689717 4 Q4KMQ2 1 +Negative regulation of jun kinase activity 0.8433256045048082 1.09622272290553 0.2729813178876612 1.0 0.854678712795931 2 Q53EL6 1 +Negative regulation of establishment of protein localization to mitochondrion 0.8433256045048052 1.096222722905519 0.2729813178876661 1.0 0.854678712795931 2 P49257 1 +Ribosomal small subunit export from nucleus 0.5897143994959011 1.0947814808046503 0.2736123816000297 1.0 0.8558121788295916 6 Q86U38,P62826 2 +Negative regulation of nervous system development 0.485812078160106 1.0938302991624422 0.2740294127878557 1.0 0.8561929564731059 15 Q96G23,Q9Y4G8 2 +Regulation of response to cytokine stimulus 0.462343253520217 1.0935049069273293 0.274172175738526 1.0 0.8561929564731059 19 P43034,Q9Y3Z3,Q15648 3 +Organic acid biosynthetic process 0.3658005092195197 1.0904166015594396 0.2755296721037097 1.0 0.8567545327095801 70 Q13126,P00374,P49748,Q9NZ01 4 +Regulation of defense response to virus 0.4925405138521053 1.0900131065001988 0.2757073706718762 1.0 0.8568882717217766 14 O43657 1 +Positive regulation of striated muscle cell differentiation 0.8505632869450054 1.086484403348712 0.277264737541302 1.0 0.85773293462613 3 Q9UGN5,Q96TA1 2 +Negative regulation of glial cell proliferation 0.8406757204372364 1.085934185523976 0.2775081111090607 1.0 0.85773293462613 2 Q96G23 1 +Negative regulation of schwann cell proliferation 0.8406757204372364 1.085934185523976 0.2775081111090607 1.0 0.85773293462613 2 Q96G23 1 +Schwann cell proliferation 0.8406757204372364 1.085934185523976 0.2775081111090607 1.0 0.85773293462613 2 Q96G23 1 +Negative regulation of dna dependent dna replication 0.8503814271446272 1.0858376998462482 0.2775508038578045 1.0 0.85773293462613 3 Q9UNS1 1 +Adipose tissue development 0.5375401745676402 1.0841561536290336 0.2782955686990582 1.0 0.8594739844968002 9 P11802,P43490 2 +Myeloid leukocyte differentiation 0.4221154575681389 1.0809876038993569 0.2797026277795149 1.0 0.8621454059754234 26 Q15648,P42345,P04062,Q00534,P05067,P43034,Q14739,O00625 8 +Tor signaling 0.4782650376964437 1.0800343470934188 0.2801268854601773 1.0 0.8626172532902459 16 P42345,P04062,Q9Y4R8,Q9P2J5,Q13315,P54646,Q96EE3,O75844 8 +Positive regulation of synaptic transmission 0.4725544406659371 1.0792364334965705 0.280482341889738 1.0 0.8632434562255462 17 P33176,Q15042,Q15334,P05067,Q14168 5 +Valine metabolic process 0.610898341940952 1.077763415217638 0.2811393500536123 1.0 0.8640620990536627 5 O15382,Q02252 2 +Regulation of response to wounding 0.4525929267395542 1.075735670165803 0.2820454897899713 1.0 0.8654585776197675 20 P42345,Q7Z460,Q16625,P10586,Q96AC1,Q4KMQ2,Q96G23 7 +Positive regulation of gtpase activity 0.419070606357362 1.0752363601119297 0.2822689203824979 1.0 0.8654585776197675 35 Q15042,Q9Y5X1,Q9Y4G8,Q66K14,Q9P258 5 +Keratan sulfate metabolic process 0.8473097456889518 1.074921366319014 0.2824099351050986 1.0 0.8654585776197675 3 P16278 1 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.8469184890656065 1.0735318227780477 0.2830325684760555 1.0 0.8659216212551276 3 O60678,Q99873 2 +Regulation of protein lipidation 0.8467244483643549 1.0728427685499164 0.2833416679471576 1.0 0.8659216212551276 3 P04062 1 +Regulation of lipoprotein metabolic process 0.8467244483643549 1.0728427685499164 0.2833416679471576 1.0 0.8659216212551276 3 P04062 1 +Regulation of toll like receptor signaling pathway 0.55815662014929 1.0725155168353808 0.2834885482546616 1.0 0.8659216212551276 8 Q9NPR9,Q9NQC3 2 +Actin filament polymerization 0.4128640071580244 1.0714324682852951 0.2839750203828575 1.0 0.8659216212551276 40 P47755,P50552,P42345,Q9UEY8,P52907,Q9NUQ9,Q9Y5X1,P07737,Q14019,Q6IBS0,Q13045,P63000,P35241,P35611,O15145,Q9UQB8,P35080 17 +Carbohydrate derivative catabolic process 0.4203100954362943 1.0701516632349013 0.2845510476153197 1.0 0.8659216212551276 32 Q13126,Q9Y3Z3,O60502,P04062,P16278,P04066,P54802,Q9BTY2,Q9NUJ1,P08236,P15586 11 +Endochondral bone morphogenesis 0.5840677881471916 1.069901963263166 0.2846634393096967 1.0 0.8659216212551276 6 O75844,P16435 2 +Antigen processing and presentation of peptide antigen via mhc class i 0.5345224181205346 1.069486807913265 0.284850370091287 1.0 0.8659216212551276 9 Q9UIQ6 1 +Mitochondrial electron transport cytochrome c to oxygen 0.5835683816249195 1.0677029145524 0.2856545433271789 1.0 0.8659216212551276 6 P00403 1 +Negative regulation of vascular associated smooth muscle cell differentiation 0.8357071878105389 1.0666796841319923 0.2861165041087932 1.0 0.8659216212551276 2 Q53EL6 1 +Regulation of carbohydrate catabolic process 0.495373166349537 1.0665634714859085 0.2861690028672634 1.0 0.8659216212551276 13 Q14108,P05067 2 +Regulation of lipid localization 0.4698054830067362 1.0628613991577798 0.2878448104536879 1.0 0.8659216212551276 17 Q8WTV0 1 +Mitochondrial cytochrome c oxidase assembly 0.5824615285672705 1.0628299527451857 0.287859073515305 1.0 0.8659216212551276 6 Q96I36,O75880,Q9Y2R0 3 +Respiratory chain complex iv assembly 0.5824615285672705 1.0628299527451857 0.287859073515305 1.0 0.8659216212551276 6 Q96I36,O75880,Q9Y2R0 3 +Cellular response to xenobiotic stimulus 0.4199788685130424 1.0622184877967682 0.2881365087237542 1.0 0.8659216212551276 29 P07099,P78417,Q86WA6,O43169 4 +Response to estrogen 0.5012571532047957 1.0617394865301544 0.2883539681322886 1.0 0.8659216212551276 12 P09601,P04062 2 +Intestinal absorption 0.5328072896312372 1.061152535587088 0.2886205859066444 1.0 0.8659216212551276 9 Q8WTV0 1 +Digestive system process 0.5074239803916216 1.0599180580245668 0.2891818795688761 1.0 0.8659216212551276 11 Q8WTV0 1 +Endomembrane system organization 0.4402766435884149 1.0594555684695643 0.2893923540782723 1.0 0.8659216212551276 151 A5D8V6,Q86XL3,Q9Y5X1,Q15042,Q14108,Q8WUX9,P49257,P42858,Q7Z3C6,Q8N4V1,Q2M389,Q12955,Q7Z460,Q9NQC3,Q9UQB8,P43034,Q9Y5P4,O75844,P46379,Q15629,Q4KMQ2,Q96CP7,O15260,O95197,Q96GC9,O43760,P50542,Q16739 28 +Megakaryocyte development 0.6757399847372886 1.0593811082822808 0.2894262498277777 1.0 0.8659216212551276 4 Q15648 1 +Central nervous system neuron axonogenesis 0.6065398919985836 1.0592864895344372 0.2894693260103242 1.0 0.8659216212551276 5 P43034 1 +Heparan sulfate proteoglycan biosynthetic process 0.6065277709592272 1.0592351343668185 0.2894927077995237 1.0 0.8659216212551276 5 Q7LGA3 1 +Heparan sulfate proteoglycan metabolic process 0.6065277709592272 1.0592351343668185 0.2894927077995237 1.0 0.8659216212551276 5 Q7LGA3 1 +Protein exit from endoplasmic reticulum 0.4566561165639872 1.0579701798755663 0.2900690377271813 1.0 0.8659216212551276 19 Q9BUN8,Q9GZP9,Q8TCT9,P49257,O15260 5 +Positive regulation of peptidyl serine phosphorylation 0.4866211907696463 1.0570650591456232 0.2904818963561661 1.0 0.8659216212551276 14 P14174,P02786,P07900,P05067,Q9H7B4,P35080 6 +Cognition 0.4158417808214139 1.0568090267926316 0.2905987537700265 1.0 0.8659216212551276 36 P43034,Q09472,P50897,Q15334,P05067,Q13641,P42858 7 +Cellular response to nitrosative stress 0.8420550859590875 1.0562776964615137 0.2908413626578494 1.0 0.8659216212551276 3 Q13315 1 +Negative regulation of proteolysis 0.3536957183743381 1.0562487257933697 0.2908545947689762 1.0 0.8659216212551276 62 P46379,O00560,Q86UE8,Q96KB5,P78559,Q96K76,P04080,Q8NDZ2,P30086,P16435,P19474,P05067,Q15392,P78318,Q92896,Q93009,O94966,Q9NVX2 18 +Dna synthesis involved in dna repair 0.5546423376510007 1.0561852014267126 0.2908836104111376 1.0 0.8659216212551276 8 P28340,P12004,Q07864,P40938,P09884 5 +Telomere maintenance via semi conservative replication 0.6747926595824383 1.055654993762848 0.291125866108948 1.0 0.8659216212551276 4 Q15554 1 +Regulation of dna damage response signal transduction by p53 class mediator 0.5313225570097446 1.0539397620706985 0.2919104969608825 1.0 0.8659216212551276 9 P14174,P61254,Q13315,O43324,O75844 5 +Reactive nitrogen species metabolic process 0.49304817045771 1.0539227743676498 0.2919182750665456 1.0 0.8659216212551276 13 P35270,P07900,P06280,P16435,Q92945,O43169 6 +Dna methylation or demethylation 0.4340666803990308 1.0529567022326412 0.292360836601071 1.0 0.8659216212551276 22 Q8NB78,Q96TA1,O75844 3 +Positive regulation of synaptic vesicle recycling 0.8317323617091767 1.0513121106022727 0.2931152667074173 1.0 0.8669452937204039 2 Q96CW1 1 +Purine nucleotide catabolic process 0.5117133700503793 1.0499190375719227 0.2937553379665596 1.0 0.8669454260363401 10 O43598,Q9Y3Z3 2 +T cell activation 0.4012604466089046 1.048188194976029 0.2945519083836287 1.0 0.8669454260363401 45 Q96J02,P49366,O96005,P24390,Q9BY67,P02786,P42345,P04062,Q00534,Q92542,P09429 11 +Vesicle cytoskeletal trafficking 0.4613275554266185 1.0475065234446557 0.2948660250674551 1.0 0.8669454260363401 18 P33176,P43034,Q92572,P42858 4 +Regulation of tolerance induction 0.8307386551838377 1.0474754328818134 0.2948803570603004 1.0 0.8669454260363401 2 P09429 1 +Pyrimidine containing compound catabolic process 0.5752877801682585 1.0458045984185764 0.2956512576716332 1.0 0.8669454260363401 7 Q02252 1 +Neuron cellular homeostasis 0.5778586082418398 1.0425791897973238 0.2971432315250952 1.0 0.8669454260363401 6 P78559,P51790 2 +De novo amp biosynthetic process 0.573889065680158 1.039586950457654 0.2985318422228635 1.0 0.8669454260363401 7 Q06203,P30520,P22102 3 +Regulation of chromatin binding 0.6706581295737771 1.0394066586180175 0.2986156485672597 1.0 0.8669454260363401 4 Q7L2J0 1 +Exit from mitosis 0.5096136196372015 1.0392425202932876 0.2986919598165274 1.0 0.8669454260363401 10 Q8WUX9,Q7Z460 2 +Anaphase promoting complex dependent catabolic process 0.502996627079502 1.0369110075453407 0.2997773334452569 1.0 0.8669454260363401 11 P30260,Q13042,Q9UJX4 3 +Positive regulation of anion transport 0.5765160264518074 1.0366769327427714 0.299886445841881 1.0 0.8669454260363401 6 P08183 1 +Positive regulation of endothelial cell apoptotic process 0.836477354671676 1.0365328374633418 0.2999536280563588 1.0 0.8669454260363401 3 Q53EL6 1 +Endothelial cell apoptotic process 0.836477354671676 1.0365328374633418 0.2999536280563588 1.0 0.8669454260363401 3 Q53EL6 1 +Response to leucine 0.6698707325157386 1.036314942826711 0.3000552371499729 1.0 0.8669454260363401 4 O00330,Q9P2J5,P42345 3 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.6692001214267713 1.0336824889091287 0.3012846220421981 1.0 0.8669454260363401 4 O75844 1 +Smooth muscle cell proliferation 0.4456006385566076 1.0309340934747175 0.3025717273210033 1.0 0.8669454260363401 20 P09601 1 +Rhythmic behavior 0.6682057731852298 1.0297804254240166 0.303113091582849 1.0 0.8678203440936708 4 P54802 1 +Appendage development 0.4884357568068287 1.0288574070890069 0.303546685765081 1.0 0.8679388830730093 13 Q8NCM8,Q96AC1,P42892,Q15648 4 +White fat cell differentiation 0.8254388870486933 1.02704990173493 0.3043969670459703 1.0 0.8695701970192237 2 Q13363 1 +Regulation of dendrite morphogenesis 0.4808535631122913 1.0249815531844189 0.3053718917939054 1.0 0.87018754939709 14 Q9Y4G8 1 +Pyramidal neuron differentiation 0.8331744570812434 1.0248640287574398 0.3054273495447503 1.0 0.87018754939709 3 O14949 1 +Positive regulation of supramolecular fiber organization 0.4050690769429269 1.0195245490947715 0.3079540046249165 1.0 0.8740408583095112 41 P50552,O14786,P42345,Q7Z460,P14373,Q9Y5X1,P46821,P07737,Q16625,P05067,Q9UQB8,Q96AC1 12 +Dna damage induced protein phosphorylation 0.663573085846862 1.011620378537347 0.3117195983821454 1.0 0.8798403216092322 4 Q13315,P27361,O14757 3 +Protein localization to presynapse 0.8283631544068966 1.00789897559235 0.3135029634888049 1.0 0.8830866605123292 3 P33176,Q14168 2 +Axo dendritic protein transport 0.8283631544068966 1.00789897559235 0.3135029634888049 1.0 0.8830866605123292 3 P33176,Q14168 2 +Regulation of protein k63 linked ubiquitination 0.5699335803768201 1.0077723147265951 0.3135637796443495 1.0 0.8830866605123292 6 Q96FW1,Q9Y263 2 +Suckling behavior 0.8281073005489464 1.0069979409446808 0.3139357636765738 1.0 0.8834269175002458 3 Q9GZP9 1 +Galactose metabolic process 0.8280323615411098 1.006734051972528 0.3140625936673866 1.0 0.8834269175002458 3 P16278 1 +Protein deneddylation 0.569612741489958 1.0063649722571966 0.3142400368285218 1.0 0.8834269175002458 6 Q92905,Q9BT78,Q7L5N1,Q99627 4 +Brain morphogenesis 0.6620374507807436 1.0056082052051574 0.3146040753244865 1.0 0.8840596851653637 4 P04062 1 +Regulation of actin filament length 0.4031482008315259 1.003622571321385 0.3155605708288362 1.0 0.8855740412938051 41 P52907,Q9Y5X1,Q14019,Q13045,O15145,P35080,P47755,P50552,Q9NUQ9,P07737,Q9UQB8,Q14247,P42345,Q6IBS0,P35241,O75083,Q9UEY8,Q9Y281,P35611 19 +Axonogenesis involved in innervation 0.8191454123882137 1.0028791458649646 0.3159191756499631 1.0 0.8857989402754867 2 P42892 1 +Axonal fasciculation 0.8191454123882126 1.00287914586496 0.3159191756499653 1.0 0.8857989402754867 2 Q9NQC3 1 +Regulation of aerobic respiration 0.4900340306352319 1.002143065771682 0.3162745008135554 1.0 0.8864045701215153 12 P14406,O14548 2 +Chromosome localization to nuclear envelope involved in homologous chromosome segregation 0.8184829413713169 1.0003404584921614 0.3171457739341865 1.0 0.8872911505825093 2 Q13315 1 +Nuclear pore complex assembly 0.5200444495072416 0.99922450462133 0.3176859477396954 1.0 0.8872911505825093 9 Q9BTX1 1 +Cellular response to chemical stress 0.3616333223994259 0.9982483130213526 0.3181589642619729 1.0 0.8872911505825093 74 Q9BPX6,P00374,P09601,Q99720 4 +Morphogenesis of an epithelial sheet 0.5645550064613869 0.9981534205210844 0.3182049692965074 1.0 0.8872911505825093 7 Q96AC1,Q7Z460,P42345 3 +Pyrimidine nucleobase metabolic process 0.4756925781160657 0.9962983322707596 0.3191052138661834 1.0 0.8872911505825093 14 P30085,P42345,Q9NRF8,Q02252,Q9BPU6 5 +Negative regulation of cell development 0.4467431600099582 0.9960815294068324 0.3192105335084156 1.0 0.8872911505825093 19 Q96G23,Q9Y4G8,Q9NQC3 3 +Regulation of natural killer cell mediated immunity 0.5915613514765813 0.9959740758526342 0.3192627412951949 1.0 0.8872911505825093 5 Q9BY67 1 +Negative regulation of supramolecular fiber organization 0.3951768489694683 0.9955434043199292 0.3194720450580388 1.0 0.8872911505825093 45 P63167,P52907,Q13045,P35080,P47755,Q9P1Y5,Q99471,P04350,Q9NUQ9,Q7Z460,P46821,P07737,P29372,Q6IBS0,P35241,Q92974,Q9UEY8,P35611,O15212 19 +Positive regulation of interleukin 1 production 0.5913943630352226 0.9952701341012888 0.3196048992793534 1.0 0.8872911505825093 5 P05067 1 +Pyrimidine containing compound transmembrane transport 0.8245738170259818 0.9945662075057492 0.319947289693179 1.0 0.8872911505825093 3 Q9BSK2 1 +Mitochondrion organization 0.4494861817101303 0.9937270077904105 0.3203557903924663 1.0 0.8872911505825093 171 P21796,P45880,Q99595,Q9NX63,Q9Y6M9,P14406,O14548,Q8N4H5,P49257,P42858,Q9NS69,Q7Z3C6,Q96CU9,O75153,Q9BSK2,O60830,Q9UDX5,Q86Y39,P03886,Q96A26,Q9Y5P4,O14925,O75880,Q13505,Q5JRX3,Q9Y512,Q9UBE0,P04062,P50542,Q9BWH2,P48507 31 +Regulation of ossification 0.494495365167966 0.99279033561068 0.3208121406447926 1.0 0.8872911505825093 11 O75844 1 +Positive regulation of dna methylation dependent heterochromatin assembly 0.5905418387867036 0.9916770389921892 0.3213550951980668 1.0 0.8872911505825093 5 Q9Y6X9,P26358 2 +Positive regulation of histone phosphorylation 0.6583036907996833 0.9910066125954152 0.3216823513692464 1.0 0.8872911505825093 4 Q13315,Q06787 2 +Positive regulation of embryonic development 0.5405136091830658 0.9906618865752388 0.3218507076326053 1.0 0.8872911505825093 8 P43034,Q96TA1 2 +Regulation of necrotic cell death 0.4937950348290278 0.989159770450099 0.3225849778204965 1.0 0.8872911505825093 11 P00403,P16989,Q7Z3C6 3 +Negative regulation of wnt signaling pathway 0.4626322987014536 0.9890453641736686 0.3226409470823383 1.0 0.8872911505825093 16 Q13641 1 +Purine containing compound biosynthetic process 0.3617677328449974 0.988041507637526 0.3231323203124452 1.0 0.8872911505825093 75 Q13126,P50897,Q8TB61,Q9NZ01,P00846,O75964 6 +Negative regulation of apoptotic signaling pathway 0.357603495308481 0.9865483668599556 0.3238640931124583 1.0 0.8882373733028437 58 Q9H300,O14786,Q86WB0,P45880,Q15233,P16989,Q96K76,P09601,Q8IWB1,P48507,P31689,P26583,P42858 13 +Regulation of steroid metabolic process 0.4864405884587116 0.983091349169238 0.3255624815682392 1.0 0.890575392891464 12 Q9UHI6,P49748,P16435 3 +Membrane protein intracellular domain proteolysis 0.8135144087446196 0.981335909004916 0.3264271202810067 1.0 0.890575392891464 2 Q8TCT9 1 +Polyol metabolic process 0.4233519895241178 0.9805357120152416 0.3268217504513182 1.0 0.890575392891464 22 P00374 1 +Positive regulation of response to endoplasmic reticulum stress 0.5876607101188626 0.9795433715832412 0.3273115695417936 1.0 0.8905875057933514 5 P46379 1 +Positive regulation of insulin secretion involved in cellular response to glucose stimulus 0.5874710273210187 0.9787450529198796 0.3277059652722784 1.0 0.8905875057933514 5 P22059,O00330 2 +Insulin secretion involved in cellular response to glucose stimulus 0.5874710273210187 0.9787450529198796 0.3277059652722784 1.0 0.8905875057933514 5 P22059,O00330 2 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.5874710273210187 0.9787450529198796 0.3277059652722784 1.0 0.8905875057933514 5 P22059,O00330 2 +Mitochondrial respiratory chain complex assembly 0.4071685726087863 0.9771886518456988 0.3284757650807579 1.0 0.8915370381586101 34 Q9BSK2,O75880,Q9Y2R0,Q9Y6M9,Q86Y39,P03886,Q9Y512,Q9H845,Q96CU9 9 +Pyrimidine nucleobase biosynthetic process 0.5373556289284338 0.976052515527091 0.329038440731594 1.0 0.8922956087473826 8 P30085,Q9NRF8,P42345 3 +Regulation of innate immune response 0.3948204130049904 0.975924690113525 0.3291017858057217 1.0 0.8922956087473826 44 Q9NZ08,Q9Y3Z3,Q15233,Q09472,Q15648,Q9BY67,Q8WXF1,P19474,Q9Y4E8,P09429,P26583,Q9NUD5 12 +Phospholipid biosynthetic process 0.3757628511954587 0.9737710274972152 0.3301702415742595 1.0 0.8930915544615418 52 O00443,P37287,Q9Y217,Q96N66,P35790,Q86YN1,Q99943,Q9NPH0,Q8TBX8,Q8WUK0 10 +Neuron death 0.3536356912933998 0.9709557154682276 0.3315703314994156 1.0 0.8930915544615418 69 O95630,O14786,Q15233,P50897,P04062,Q9UGN5,O75915,P09601,Q13315,Q13155,P05067,P48507,Q15392,Q96A26,Q99720,Q9UNH7,P55210 17 +Regulation of vacuole organization 0.4837968183647377 0.969086550588117 0.332502007542887 1.0 0.8930915544615418 12 Q14108,Q8TBX8 2 +Regulation of chaperone mediated autophagy 0.8172923978069504 0.969022325891989 0.3325340500448162 1.0 0.8930915544615418 3 P10619 1 +Thymus development 0.5137146865403754 0.9685883454886802 0.3327506205464443 1.0 0.8930915544615418 9 O75844 1 +Adenylate cyclase modulating g protein coupled receptor signaling pathway 0.4771821661359537 0.9677967800526436 0.3331458722458982 1.0 0.8930915544615418 13 P07602,Q9Y4G8 2 +Glycosylceramide catabolic process 0.809870818151712 0.9674405936404978 0.3333238253239123 1.0 0.8930915544615418 2 P04062 1 +Vascular transport 0.4894447522853781 0.9666241560070146 0.3337319543502022 1.0 0.8930915544615418 11 P08183,P53985,Q99808 3 +Amp biosynthetic process 0.4947843223331837 0.963990874249494 0.3350505011397513 1.0 0.8953472976587875 10 Q06203,P30520,P22102 3 +Myotube cell development 0.8153721441851729 0.962303364456128 0.3358972394432682 1.0 0.8960076466826299 3 Q9H7B4 1 +Regulation of protein containing complex assembly 0.3861394288347761 0.961432576157116 0.336334711372094 1.0 0.8964228880390709 101 P45880,P02786,P52907,Q9Y5X1,P07900,Q14019,Q13315,P63000,Q13045,O15145,Q96AC1,P47755,Q9P1Y5,P50552,Q09472,P04350,Q7Z460,P46821,P07737,Q16625,Q15058,Q9UQB8,Q5T2T1,P42345,Q969V3,Q6IBS0,P35241,P63244,P09429,P04062,P50542,P35611,Q9NR31 33 +Bleb assembly 0.8149955861746707 0.9609866754577872 0.3365588675326583 1.0 0.8966446881251139 3 Q9NR77 1 +Cell activation involved in immune response 0.4061765461647296 0.9606807218360583 0.3367127272831414 1.0 0.8966791004501237 31 Q9UQ84,P42345,P02786,Q9NQT5,P09601,P05067,P52701,P09429 8 +Membrane biogenesis 0.4199551388163932 0.9576095357541023 0.3382596888997053 1.0 0.8985759642821703 22 Q8WUX9,Q16739,Q86XL3,Q96CP7 4 +Negative regulation of mapk cascade 0.40589155133983 0.957584205166327 0.3382724669059727 1.0 0.8985759642821703 29 P43034,Q96KB5,P04062,Q9Y3S1,P30086,Q96S59,Q8IV63,P78318,Q53EL6,P31689 10 +Potassium ion import across plasma membrane 0.5820346059898465 0.9558934886187074 0.3391260490125196 1.0 0.8997163985895121 5 P05026,P05023,Q9Y3S1 3 +Pyrimidine ribonucleoside triphosphate biosynthetic process 0.5324527728810091 0.9534032746085742 0.3403857829183603 1.0 0.902682097093209 8 P17812,O75414,Q9NRF8 3 +Intracellular mrna localization 0.8058959920503502 0.952323873489298 0.3409327539238713 1.0 0.9029245981331502 2 Q99729 1 +T cell mediated cytotoxicity 0.5536350911653048 0.9498394083492212 0.3421938583679731 1.0 0.903379994384212 7 P15151,Q9BY67 2 +Positive regulation of endocytosis 0.4451463959290551 0.9490077992019104 0.3426166454120536 1.0 0.903379994384212 18 Q4KMQ2,P50897 2 +Positive regulation of small molecule metabolic process 0.4670064079566973 0.948101752573872 0.3430776561488891 1.0 0.903379994384212 14 P00403,P16435 2 +Response to steroid hormone 0.3491861489212308 0.9467582727751136 0.3437619690130988 1.0 0.903379994384212 67 Q15648,P04062,P16278,O43251,O15118,P16435,Q9H7B4,O15173 8 +Positive regulation of neuron projection development 0.4042165270779291 0.9459170024227058 0.3441909206833518 1.0 0.903379994384212 31 Q14108,Q9Y4G8 2 +Phosphatidylinositol phosphate biosynthetic process 0.5307721245744392 0.9456491703578942 0.3443275560723777 1.0 0.903379994384212 8 O00443,Q8TBX8 2 +Regulation of metal ion transport 0.3754208420616354 0.9445834005452834 0.3448716048412832 1.0 0.903379994384212 51 P21796,Q12955,Q96GC9,Q9Y3S1,O43865,P78417,Q4KMQ2,P42858 8 +Nadh dehydrogenase complex assembly 0.4102987955145805 0.944402174145773 0.3449641708881763 1.0 0.903379994384212 23 Q9Y6M9,P03886,Q96CU9 3 +Protein k29 linked ubiquitination 0.8100361262104769 0.9436730796023276 0.3453367347772087 1.0 0.903379994384212 3 Q15386 1 +Positive regulation of monocyte chemotaxis 0.6460908035763837 0.9434255689463962 0.3454632698618627 1.0 0.903379994384212 4 Q4KMQ2 1 +Regulation of sulfur metabolic process 0.6458105979219388 0.9423374174994816 0.3460199169816711 1.0 0.903379994384212 4 Q15120 1 +Regulation of exocytosis 0.4000775872855883 0.9394157529571008 0.3475173281583608 1.0 0.9048545352274916 37 O00560,Q7Z460,P09601 3 +Cellular response to thyroid hormone stimulus 0.8087622704344901 0.939234585711676 0.3476103155000318 1.0 0.9048545352274916 3 Q15648 1 +Ion transport 0.4583330038106972 0.9389674438964654 0.3477474597031149 1.0 0.9048545352274916 191 P08183,Q14728,P21796,P45880,Q9UBX3,Q15042,O14548,Q15334,Q9C0H2,P53985,P00846,O75964,O15173,P42858,Q96ES6,Q8N4V1,Q12955,P00403,Q9BQT8,O43826,P05067,Q96NB2,Q9HD20,Q9UHG3,Q70HW3,P78417,O43681,Q9Y5P4,O75844,O43865,Q99808,Q8TB61,Q9H2D1,Q4KMQ2,Q9UDW1,Q9BPX6,P07602,Q9Y6M7,Q9NZJ7,Q96GC9,O75915,O60831,P21281,O43772 44 +Autophagosome membrane docking 0.8019211659489944 0.9372526460369728 0.348628615006229 1.0 0.905711586056436 2 Q96GC9 1 +Negative regulation of receptor binding 0.8019211659489942 0.937252646036972 0.3486286150062294 1.0 0.905711586056436 2 P10586 1 +Calcium ion regulated exocytosis of neurotransmitter 0.801921165948994 0.9372526460369706 0.3486286150062301 1.0 0.905711586056436 2 Q15042 1 +Negative regulation of actin filament bundle assembly 0.5288980446816086 0.9370089612927236 0.3487539483494484 1.0 0.905711586056436 8 P63167,Q7Z460 2 +Negative regulation of lipid biosynthetic process 0.5537374914483459 0.936941502619765 0.3487886491415071 1.0 0.905711586056436 6 P49748 1 +Positive regulation of ligase activity 0.8079294107110186 0.9363345963316656 0.3491009408210472 1.0 0.9058615436040364 3 P48507 1 +Lymphocyte migration 0.489047484018898 0.9349728286362964 0.3498023024386434 1.0 0.9058615436040364 10 P04062 1 +Negative regulation of ubiquitin protein ligase activity 0.5499940015433662 0.933776141418254 0.3504193790397885 1.0 0.9058615436040364 7 P62913,P62841,Q13257,P62829,P46777 5 +Ventricular cardiac muscle tissue development 0.5523796157454568 0.9310254749814282 0.3518403866371504 1.0 0.9058615436040364 6 Q15648,O75844 2 +Positive regulation of glycolytic process 0.8002649884067627 0.9309868607697838 0.3518603608641211 1.0 0.9058615436040364 2 P05067 1 +Positive regulation of wound healing 0.5274132463943548 0.930168429263333 0.3522838852009662 1.0 0.9058615436040364 8 Q96AC1,Q4KMQ2,P42345,Q16625 4 +Histone h3 deacetylation 0.5758781317800518 0.9300875263107898 0.3523257686165615 1.0 0.9058615436040364 5 P23246,Q9H4L7 2 +Regulation of cartilage development 0.5519996461633354 0.9293707158554186 0.3526969986745758 1.0 0.9058615436040364 6 Q92896,P16435 2 +Regulation of chondrocyte differentiation 0.5519996461633354 0.9293707158554186 0.3526969986745758 1.0 0.9058615436040364 6 Q92896,P16435 2 +Monovalent inorganic cation homeostasis 0.4016416177426614 0.9293074880577216 0.3527297556885254 1.0 0.9058615436040364 27 P50897,Q9Y6M7,Q93050,O75503,Q96AX1 5 +Bone cell development 0.5265663768750604 0.9262688863365424 0.3543062610220091 1.0 0.9076910835853872 8 Q15648,Q09472 2 +Vasculature development 0.3707463776579559 0.9261829510757528 0.3543509110820635 1.0 0.9076910835853872 89 P35613,Q9NZ08,O00443,Q15648,Q96AY3,P42785,P09601,Q13685,O95470,Q96TA1,Q9Y4G8,Q53EL6,Q12948 13 +Positive regulation of transcription regulatory region dna binding 0.5048751310209475 0.925919858496889 0.3544876302599835 1.0 0.9076910835853872 9 Q96TA1,Q09472 2 +Negative regulation of axon extension 0.8048795386660498 0.925728402253709 0.3545871437063417 1.0 0.9076910835853872 3 Q9NQC3 1 +Myeloid leukocyte activation 0.4353399187734279 0.9250519723575142 0.3549388737501169 1.0 0.9076910835853872 19 P09429,P05067,P09601 3 +Metal ion export 0.5261942290569717 0.9245557481110496 0.3551970404475288 1.0 0.9076910835853872 8 P05026,Q4KMQ2,P23634 3 +Cellular response to molecule of bacterial origin 0.4012196035652757 0.9241474065204706 0.3554095739815417 1.0 0.9076910835853872 28 Q53EL6,Q8WTV0 2 +Protein localization to nucleoplasm 0.4811899391958998 0.9239537669206412 0.3555103875145053 1.0 0.9076910835853872 11 P78371 1 +Protein localization to nuclear body 0.4811899391958998 0.9239537669206412 0.3555103875145053 1.0 0.9076910835853872 11 P78371 1 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.4866718337953015 0.9229757071644328 0.3560198650955364 1.0 0.9076910835853872 10 O43657,Q9Y4E8 2 +Positive regulation of mapk cascade 0.3946050614972176 0.9219240894432192 0.3565681728238883 1.0 0.90812118314875 40 P18615,O14786,P09429,O00560,Q99873,O75915,P05067,Q9Y4G8,Q96AC1,Q13641 10 +Protein localization to synapse 0.4806795011786903 0.9213197608297966 0.3568835071001259 1.0 0.9085605730976396 11 P33176,Q15334,Q14168,Q9UQB8 4 +Positive regulation of mammary gland epithelial cell proliferation 0.7969526333222976 0.9184805875055728 0.3583673174756248 1.0 0.9101983503671176 2 Q9NQC3 1 +Jnk cascade 0.4400657348483006 0.9181663754873404 0.3585317692913428 1.0 0.9101983503671176 18 Q96J02,P43034,P31689,P05067,P09429,O00560,Q53EL6 7 +Cell maturation 0.4212341603287453 0.9180566198616926 0.3585892242087729 1.0 0.9101983503671176 21 O75503,P05067,P04062 3 +Transcription coupled nucleotide excision repair 0.6395059195668857 0.917899714151668 0.3586713713251122 1.0 0.9101983503671176 4 Q93009,P19447 2 +Folic acid containing compound catabolic process 0.7966213978138498 0.917231849687211 0.3590211604308269 1.0 0.910722736308182 2 Q9NRN7 1 +Multicellular organism growth 0.3997833435457123 0.9157514487710456 0.3597972736267365 1.0 0.9109832534094284 27 Q09472,P11802,O95470,Q13315,P50542,P05067,O75844 7 +Response to oxygen levels 0.3471327069664778 0.9154672007981864 0.3599464136219554 1.0 0.9109832534094284 59 P30519,P09601 2 +Positive regulation of mitophagy in response to mitochondrial depolarization 0.6388548701839578 0.9153813543750368 0.359991463386875 1.0 0.9109832534094284 4 O95140,Q709C8 2 +Maintenance of location in cell 0.396854731098553 0.9138544678172956 0.3607933215043601 1.0 0.911585415973624 37 P10253,P24390,Q12955,P43034,P78417,P42858 6 +Maintenance of dna methylation 0.5719935474761324 0.9138480076599088 0.3607967164925618 1.0 0.911585415973624 5 P26358,P49711 2 +Regulation of erad pathway 0.5477461048455554 0.9108684432738234 0.3623646945537406 1.0 0.9128406531209804 6 P46379 1 +Positive regulation of nik nf kappab signaling 0.4600161810581851 0.9094118296755598 0.3631327797545358 1.0 0.9129768274050551 14 Q53EL6,P05067 2 +Hindbrain development 0.398561935349719 0.9072824255385143 0.3642574653826316 1.0 0.9143898767797926 33 P04062,Q9UKA9,P54802,O14949,O43251,Q12948 6 +Selective autophagy 0.3976063011465162 0.9070167064765292 0.3643979626545992 1.0 0.9143898767797926 25 P21796 1 +Skin development 0.3973397762965127 0.9056987355972064 0.3650953319425984 1.0 0.9143898767797926 35 Q15648,P04062,Q08J23,Q15392,Q16739,O75844,Q12948 7 +Negative regulation of protein catabolic process 0.3897306111336505 0.9046602368349396 0.3656454127222703 1.0 0.9143898767797926 42 P46379,Q86UE8,Q96KB5,Q16850,P10619,O00560,Q13257 7 +Negative regulation of amyloid fibril formation 0.6358717670945349 0.9038552707383368 0.3660721496633341 1.0 0.9143898767797926 4 Q99471,O15212 2 +Muscle cell differentiation 0.3593720937032665 0.902277200280688 0.3669096339201845 1.0 0.9157626877207586 55 Q8IV08,Q96TA1,Q53EL6,Q9H7B4,Q7Z4V5,O75844 6 +Regulation of dna methylation dependent heterochromatin assembly 0.5453472090096465 0.9004520827383118 0.3678797145422432 1.0 0.9173206240175664 6 Q9Y6X9,P26358 2 +Sulfur compound catabolic process 0.5207984896337005 0.8997513305170042 0.3682526000647153 1.0 0.9173206240175664 8 P16278,P15586 2 +Positive regulation of wound healing spreading of epidermal cells 0.7972166998011956 0.8991767105994659 0.3685585433344813 1.0 0.9173589408035878 3 Q96AC1,P42345 2 +Production of molecular mediator of immune response 0.3978969203093415 0.8979165373916326 0.3692300474023953 1.0 0.917952935355232 30 Q9UQ84,P09601 2 +Cell cycle dna replication initiation 0.5441128750367106 0.8950978793746152 0.3707347674804184 1.0 0.9188214221700124 6 P33993,P49736,P09884,Q9BRX5 4 +Regulation of neuron projection arborization 0.795641709651123 0.8937372308139326 0.3714625003172063 1.0 0.919514783583692 3 Q15334 1 +Response to misfolded protein 0.497841616976191 0.8920862575492109 0.3723467002304634 1.0 0.9196980023499068 9 P46379,Q9BUN8,Q9HCN8 3 +Ribosome associated ubiquitin dependent protein catabolic process 0.5667583700618608 0.8920203873774263 0.3723820048843305 1.0 0.9196980023499068 5 O94822,O60524 2 +Lipoprotein biosynthetic process 0.462644870937692 0.8892335894057212 0.373877554268768 1.0 0.919899795436274 13 Q16739,P37287,Q15042,P04062 4 +Glycosyl compound metabolic process 0.3956673521620954 0.8890005440536941 0.3740027874120364 1.0 0.919899795436274 26 Q13126,P04062,Q9NUJ1,O60725,O43598 5 +Regulation of leukocyte migration 0.3943494418870096 0.8886051331708464 0.3742153313719227 1.0 0.9199219235657544 24 P05067,P09601,Q4KMQ2 3 +Negative regulation of receptor mediated endocytosis 0.4966058750939471 0.8861542306403452 0.3755344233186708 1.0 0.9209712415832504 9 O00560,P05067 2 +Interleukin 1 production 0.5420114880621841 0.885991473794671 0.3756221216998086 1.0 0.9209712415832504 6 P05067 1 +Positive regulation of oligodendrocyte differentiation 0.6311896727673061 0.8858094614035046 0.3757202105395409 1.0 0.9209712415832504 4 P42345 1 +Chromosome organization involved in meiotic cell cycle 0.4397285931320849 0.8842465107657327 0.3765631558705893 1.0 0.9212684997155782 17 P46379,Q92791,Q9BTX1,Q15003 4 +Cytoplasmic translation 0.3855097457065454 0.882652414502793 0.3774240998139957 1.0 0.9212684997155782 108 Q9Y3U8,P55039,P41214,P15880,P50914,P39023,P32969,Q06787,P46776,P62829,P84098,Q9NR50,Q13347,O43583,P27635,P18621,P55010,P20042,P16989,P30050,P46782,P67809,P61513,P62753,Q15056,Q02543,P62917,P62701,P62244,P83731,P62266,Q9BWF3,P62888,P42345,P46779,Q9H2U1,Q02878,P61313,O60524,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,Q14103,P36578,P46781,P47914,Q9ULC4,P61254,P08708,P62847,P62277,P46783,Q07020,Q14240,P46777,P83881 61 +Regulation of body fluid levels 0.3736312714091793 0.8819887498988487 0.3777828910649579 1.0 0.9212684997155782 49 Q15648,P04062,Q9BWH2,Q13505,P00403,Q16739,P49257,Q4KMQ2 8 +Response to nerve growth factor 0.4784937216054068 0.8817768001820355 0.3778975198663987 1.0 0.9212684997155782 10 P05067,Q9Y4G8 2 +Positive regulation of cytoplasmic transport 0.6300961219754662 0.8816028895343089 0.3779915919941294 1.0 0.9212684997155782 4 P35241,Q9UL25,P26038 3 +Positive regulation of early endosome to late endosome transport 0.6300961219754662 0.8816028895343089 0.3779915919941294 1.0 0.9212684997155782 4 P35241,Q9UL25,P26038 3 +Regulation of protein containing complex disassembly 0.3880919101331924 0.8792682589622914 0.3792558417418494 1.0 0.9220263272755336 41 P47755,Q9P1Y5,Q9UEY8,P04062,P78559,P52907,Q7Z460,P46821,P48681,Q6IBS0,Q13045,P35241,P35611,P29372,P63241,Q92974,O75844 17 +Ampa glutamate receptor clustering 0.7863530970520085 0.8786996968152371 0.3795641230956652 1.0 0.9220263272755336 2 Q15334 1 +Regulation of glutamate receptor clustering 0.7863530970520085 0.8786996968152371 0.3795641230956652 1.0 0.9220263272755336 2 Q15334 1 +Positive regulation of translational initiation 0.4777825568652413 0.8782022952294369 0.379833946662258 1.0 0.9221846712348228 10 O15514,O75794,P42345,Q07666 4 +Regulation of proteasomal protein catabolic process 0.3398256253173868 0.877155260323218 0.3804023129979172 1.0 0.9226532654566336 60 P62191,P46379,O75150,O00560,Q86UE8,Q96KB5,P04062,P78559,O00487,Q9UL46,O94966,Q06787,P63244,Q04323,O15372,Q6ZXV5,Q93009,Q96HY6 18 +Positive regulation of interleukin 8 production 0.5393818537873025 0.874612157096961 0.3817849707121978 1.0 0.9243479283222398 6 P09429 1 +Regulation of behavior 0.5618670958310088 0.8716917500064555 0.3833765621453888 1.0 0.9263312887206676 5 Q15334 1 +Fat cell differentiation 0.393235057938201 0.8714282376417736 0.3835203732301537 1.0 0.9263312887206676 26 Q9NZ08,Q15648,Q13363,Q09472,P56545,Q86X55,Q8N4Q0,Q02252 8 +Cd4 positive alpha beta t cell activation 0.6270899039301537 0.8700555100165224 0.3842700693341609 1.0 0.9272163650885928 4 P09429 1 +Microglial cell activation 0.7879687062715486 0.867329527673536 0.3857614824661417 1.0 0.9279849570052222 3 P05067 1 +Heart process 0.3934000495765554 0.8667773526061875 0.3860640132258119 1.0 0.9279849570052222 28 P78417,O75844 2 +Peptidyl glutamic acid modification 0.6261186609214382 0.8663301482157276 0.3863091378333783 1.0 0.9279849570052222 4 P09874,Q9Y6A4,P38435 3 +Positive regulation of protein dephosphorylation 0.4582090878775295 0.8653603999376398 0.3868410089238947 1.0 0.9279849570052222 13 P63167,Q8IV63,Q86XL3,P04062 4 +Fibroblast proliferation 0.4519921158192277 0.8651396450916222 0.3869621471960047 1.0 0.9279849570052222 14 P11802,Q14149,O75844 3 +Nucleotide excision repair dna gap filling 0.7820470354422031 0.8626493770446598 0.3883302734046725 1.0 0.9279849570052222 2 P28340 1 +Positive regulation of natural killer cell mediated cytotoxicity 0.6251231427604466 0.8625144426627469 0.3884044889379723 1.0 0.9279849570052222 4 Q9BY67 1 +Positive regulation of natural killer cell mediated immunity 0.6251231427604466 0.8625144426627469 0.3884044889379723 1.0 0.9279849570052222 4 Q9BY67 1 +Multicellular organism aging 0.4635811541728979 0.8624588393255223 0.3884350739555025 1.0 0.9279849570052222 12 P04062,Q13315,P43246,P52701,O75844 5 +Regulation of system process 0.3517895796565507 0.8584393263292526 0.39064992003407 1.0 0.9308295098339904 56 P10253,P04062,P42892,Q9UQB8,P78417,O75844 6 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.3430541932043981 0.8569476140662478 0.3914738367792367 1.0 0.9313973633468602 69 O00443,P43490,P11802,O95470,Q96TA1,Q9Y4G8,Q9NQC3,Q9UQB8 8 +Vascular process in circulatory system 0.3919819865960773 0.8550677091587112 0.3925136647056555 1.0 0.9328247795507584 32 P08183,O00443,Q9HB40,P42892,P53985,P48507,Q12948 7 +Positive regulation of innate immune response 0.3920571907546991 0.854581863331524 0.392782671673674 1.0 0.9328937782317896 31 Q15233,Q09472,Q15648,Q9BY67,Q8WXF1,P09429,P26583,Q9NUD5,P15151 9 +Trna threonylcarbamoyladenosine metabolic process 0.5576503216012925 0.8542209021649815 0.3929826038448909 1.0 0.9328937782317896 5 Q9NPF4 1 +Positive regulation of protein containing complex disassembly 0.5310312679430587 0.8505963546581634 0.3949936151202442 1.0 0.9329880779584376 7 Q9Y281,P63241,P04062,P48681 4 +Regulation of membrane depolarization 0.5337785182264929 0.8504287168544161 0.3950867760646344 1.0 0.9329880779584376 6 P48507 1 +Vitamin d metabolic process 0.7827055323488716 0.8493084782810583 0.3957096644025228 1.0 0.9329880779584376 3 P04062 1 +Muscle contraction 0.3844238058525551 0.8490913236351014 0.3958304779183001 1.0 0.9329880779584376 41 O00443,P78417,Q9Y5P4,P10253 4 +Establishment of spindle orientation 0.4609472873550733 0.8486435319044108 0.3960796762089469 1.0 0.9329880779584376 12 P43034,Q15334,Q7Z460,P42858 4 +Regulation of long term neuronal synaptic plasticity 0.6213605865423263 0.8481189443745711 0.3963717322127957 1.0 0.933042290140212 4 P05067 1 +Cell migration involved in gastrulation 0.7780722093408454 0.847894042829885 0.3964969824792614 1.0 0.933042290140212 2 Q4VCS5 1 +Interleukin 6 production 0.4663751856025399 0.8477719774372068 0.3965649721061197 1.0 0.933042290140212 11 P05067,P04062 2 +Positive regulation of epithelial cell proliferation 0.4219861527581722 0.8422637704136181 0.3996403255888467 1.0 0.9364684167205316 19 O14786,Q15648,P09601,P15291,Q9NQC3,P09429,P26583 7 +Synapse maturation 0.6194895591647259 0.8409761289706699 0.4003613074956975 1.0 0.9367777264757732 4 P63104,P07196,P07737 3 +Nucleotide salvage 0.5537962141318966 0.838299829933662 0.4018623313950735 1.0 0.9388793430359006 5 P30566,P55263,Q9BZX2 3 +Mechanoreceptor differentiation 0.5062868696627149 0.8334086449466357 0.4046143007834715 1.0 0.9446444703062186 8 Q9Y6M7,P43034,P54802 3 +Long chain fatty acid biosynthetic process 0.7777243122397715 0.8323266286578097 0.4052246039914036 1.0 0.945166787084976 3 O00154 1 +Neuron projection maintenance 0.7776161359813186 0.8319586596629195 0.4054322794647751 1.0 0.945166787084976 3 P05067 1 +Negative regulation of protein polyubiquitination 0.6164550472572128 0.8294146251805662 0.4068698285144054 1.0 0.9471298386420224 4 Q96FW1 1 +Negative regulation of protein k63 linked ubiquitination 0.6164550472572128 0.8294146251805662 0.4068698285144054 1.0 0.9471298386420224 4 Q96FW1 1 +Hippo signaling 0.6162276741089437 0.8285495040600911 0.407359371623974 1.0 0.9474014335782062 4 Q4VCS5 1 +Negative regulation of microtubule polymerization or depolymerization 0.4453110482478511 0.8284190039161091 0.4074332477632776 1.0 0.9474014335782062 14 P04350 1 +Calcium ion transport into cytosol 0.4510002231748737 0.8266884098704499 0.4084136922695667 1.0 0.9493342748333882 13 P78417 1 +Sensory perception 0.3880681902098877 0.8248650180994257 0.4094482286552061 1.0 0.9497525389589688 30 Q14108,Q9H6K4,P50897 3 +Positive regulation of cytoskeleton organization 0.3753207460910372 0.8243910244549105 0.4097174131156165 1.0 0.9497525389589688 45 Q9Y5X1,P63000,Q96AC1,P35080,O14786,P50552,Q7Z460,P46821,P48681,P07737,Q16625,Q9UQB8,Q14247,P42345,Q9UHV9,O75083,P23396,Q9Y281,P14373 19 +Macroautophagy 0.3679510103317809 0.8211839739852749 0.4115414835977233 1.0 0.9508864289250452 96 A5D8V6,P21796,P04062,Q93050,Q96GC9,P09601,O15118,Q15042,P21281,Q8TBX8,Q96AX1,Q8WUX9,P42858,Q7Z3C6 14 +Anatomical structure arrangement 0.7707850281550221 0.8210007078444317 0.4116458650238161 1.0 0.9508864289250452 2 O14786 1 +Cartilage development involved in endochondral bone morphogenesis 0.6141784207752627 0.8207599314891231 0.4117830259545512 1.0 0.9508864289250452 4 O75844 1 +Regulation of nmda receptor activity 0.7740225314778206 0.8197551960504184 0.4123556772310222 1.0 0.9508864289250452 3 Q15334,P05067 2 +Cellular pigmentation 0.4823066996388108 0.8178297493631806 0.4134544083940885 1.0 0.9508864289250452 9 Q9BXS5,Q96AX1 2 +Regulation of calcium ion dependent exocytosis 0.5488209633788693 0.8178184953775188 0.4134608354260973 1.0 0.9508864289250452 5 Q15042 1 +Necrotic cell death 0.4367948147856811 0.815763854734887 0.4146352098960879 1.0 0.9509405931358728 15 P00403,P16989,Q7Z3C6 3 +Blastocyst growth 0.5224829525819386 0.8134186725782677 0.4159780571612368 1.0 0.9524246391956516 7 Q9BRT9,O14757,Q6PD62,Q9Y3A5,P61201 5 +Negative regulation of neuron differentiation 0.5221335398163415 0.8119039817753586 0.4168467295056637 1.0 0.9524246391956516 7 Q15648 1 +Regulation of embryonic development 0.4109458635991044 0.8101253708287663 0.4178681240483364 1.0 0.952602669265317 20 P43034,Q7Z460,P46379,Q96TA1 4 +Negative regulation of smooth muscle cell apoptotic process 0.7678039085790036 0.8100605373129769 0.4179053835145394 1.0 0.952602669265317 2 P26358 1 +Protein import 0.3482122888992969 0.8083702132198459 0.4188774939406272 1.0 0.95304077408209 78 Q15648,O60830,Q99595,Q9Y512,O14925,Q9NS69 6 +Regulation of lipase activity 0.4634029490023309 0.8062620801733578 0.4200917500653038 1.0 0.95412164901272 10 P40616,P50897,P16435 3 +Post translational protein modification 0.4578899391059202 0.8044393571047125 0.4211432790524201 1.0 0.9557515327477948 11 Q92905,Q8TBC4,O60725,O75718,Q9Y4P8 5 +Regulation of anion transmembrane transport 0.609828757579408 0.8042722657070331 0.421239751308522 1.0 0.9557515327477948 4 P08183 1 +Regulation of synapse assembly 0.4793753741786414 0.8039050697061201 0.4214518019498914 1.0 0.9558917518735148 9 Q13641 1 +Erk1 and erk2 cascade 0.3820416751252119 0.8033347519872709 0.4217812767161284 1.0 0.9559574216131134 38 P09429,Q9Y3S1,Q8IV63,P05067,Q9Y4G8,Q13641 6 +Fatty acid catabolic process 0.3773851886733067 0.8020945330974943 0.4224982771121421 1.0 0.9566992578513296 42 Q9BWD1,P23786,Q8NCC3 3 +Production of sirna involved in rna interference 0.7685637475554474 0.8012958811895907 0.4229603747593886 1.0 0.95677478291558 3 Q15631 1 +Metencephalon development 0.384413487600595 0.8011509875701673 0.4230442414871938 1.0 0.95677478291558 28 O14949,P54802,P04062,Q12948 4 +Protein localization to chromosome telomeric region 0.4249513738509222 0.7972727341460804 0.4252926519948805 1.0 0.9592153490296952 17 P78371 1 +Regulation of neurotransmitter receptor activity 0.6079500432756537 0.7971709493201228 0.4253517553888506 1.0 0.9592153490296952 4 P05067 1 +Regulation of biological process involved in symbiotic interaction 0.4779037103942873 0.7969260455626346 0.4254939833029227 1.0 0.9592153490296952 9 Q96KP1,P14373,Q9BTY2,P19474 4 +Sulfur amino acid metabolic process 0.4562695946796762 0.7961945235286471 0.4259189801870386 1.0 0.9595242747698088 11 Q13126 1 +Regulation of chromatin assembly or disassembly 0.4387549442049354 0.7925361653123896 0.4280481129927773 1.0 0.9622763586077914 14 Q86UE8 1 +Monocarboxylic acid catabolic process 0.3715060451973295 0.7917185313158783 0.4285248145211939 1.0 0.9626660935908058 45 Q9BWD1,P23786,Q8NCC3 3 +Negative regulation of cellular senescence 0.7656433168461818 0.7914603185339282 0.4286754233169998 1.0 0.9626660935908058 3 Q00534 1 +Synaptic vesicle transport 0.4602656758934008 0.7906634468355076 0.4291404119087962 1.0 0.9633702542567968 10 P33176,Q92572 2 +Response to iron ii ion 0.7618416694269668 0.7882930274950007 0.4305253251446665 1.0 0.9639914853000884 2 O00330 1 +Epithelial cell proliferation 0.3800207993197768 0.7873011936195944 0.4311055711246518 1.0 0.9639914853000884 38 O14786,Q15648,P09601,Q9UII2,P15291,Q8WTV0,Q00534,Q92542,Q9NQC3,P52758,P09429,Q12904,P26583 13 +Inner ear receptor cell development 0.5163286914728509 0.7868017727152776 0.431397915612747 1.0 0.9639914853000884 7 Q9Y6M7,P43034,P54802 3 +Protein processing 0.3725566272510238 0.7865303027219943 0.4315568733764785 1.0 0.9639914853000884 44 Q8NCM8,P55210,P67812,P42892,Q8TCT9,O75503,Q5JRX3,Q15392,Q92896,Q9H300,O75844 11 +I kappab kinase nf kappab signaling 0.3739945851826304 0.7857231966185302 0.4320296703865662 1.0 0.9639914853000884 43 O43657,P09601 2 +Regulation of adherens junction organization 0.7608479629016272 0.7846801766951691 0.4326411082535426 1.0 0.9639914853000884 2 P35611 1 +Regulation of phospholipase a2 activity 0.7636194746036952 0.7846612495496467 0.4326522083272208 1.0 0.9639914853000884 3 P50897 1 +Cell death in response to oxidative stress 0.4066457336660027 0.7829988899124598 0.4336277639264427 1.0 0.9639914853000884 20 Q15233,Q99720,P04062 3 +Isoleucine metabolic process 0.517921237331841 0.7825319226368146 0.4339020322704594 1.0 0.9639914853000884 6 O15382 1 +Positive regulation of release of cytochrome c from mitochondria 0.5400541683080775 0.7819409985950505 0.434249249006936 1.0 0.9639914853000884 5 Q96A26 1 +Negative regulation of cellular protein catabolic process 0.3818647500095681 0.780372563427513 0.4351716124556324 1.0 0.9639914853000884 29 P46379,O00560,Q86UE8,Q96KB5,P78559,O94966,O15372,Q93009,Q96HY6,P62829 10 +Maintenance of protein location in cell 0.4117182698800971 0.7790384814829255 0.4359570468392959 1.0 0.9639914853000884 19 O94901,P24390,Q12955,Q14149,Q6IBS0 5 +Regulation of cyclic nucleotide phosphodiesterase activity 0.7591917853593952 0.7786685715333748 0.4361749742074479 1.0 0.9639914853000884 2 O00170 1 +Locomotor rhythm 0.7618316620346407 0.7786668754237936 0.4361759735917199 1.0 0.9639914853000884 3 P54802 1 +Purine nucleoside monophosphate biosynthetic process 0.4473537050039226 0.7777236431682917 0.4367319507707634 1.0 0.9639914853000884 12 P22102,P12268,P30566,P30520,P49915,Q06203 6 +Long chain fatty acid transport 0.4470393144406007 0.7760919732836041 0.4376946826692776 1.0 0.9652040107944346 12 P23786 1 +Regulation of cilium assembly 0.4256323024516595 0.7755035912152227 0.4380421442344908 1.0 0.9653010466296608 16 Q66K14,Q9NT62,P42858 3 +Positive regulation of metaphase anaphase transition of cell cycle 0.4934333024653763 0.7752000931880879 0.4382214331425667 1.0 0.9653617581901002 8 P30260,Q13042 2 +Intrinsic apoptotic signaling pathway in response to osmotic stress 0.75786684332561 0.7738682224073545 0.4390087233027389 1.0 0.965424644884909 2 P16989 1 +Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 0.75786684332561 0.7738682224073545 0.4390087233027389 1.0 0.965424644884909 2 P16989 1 +Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 0.75786684332561 0.7738682224073545 0.4390087233027389 1.0 0.965424644884909 2 P16989 1 +Cellular response to muramyl dipeptide 0.7578668433256088 0.77386822240735 0.4390087233027415 1.0 0.965424644884909 2 P08670 1 +Glycerolipid metabolic process 0.3263354522446363 0.772337700136718 0.4399144420489658 1.0 0.9663674509377532 61 O00443,P37287,Q9Y217,Q96N66,Q8N2K0,P35790,Q8NCC3,Q99943,Q13315,Q9NPH0,Q8WTV0,Q8TBX8,P43034,Q8WUK0 14 +Regulation of phosphoprotein phosphatase activity 0.4511493758194695 0.7702113786052254 0.44117451531856 1.0 0.9668454242014052 11 Q8IV63,Q8NFC6,P42858 3 +Regulation of protein dephosphorylation 0.377443768156148 0.7686553646947006 0.4420979290625895 1.0 0.9675359562078412 24 P63167,Q8NFC6,P04062,Q86XL3,Q8IV63,P42858 6 +Biological process involved in interaction with host 0.3584650317587829 0.7655831312279149 0.4439243847863223 1.0 0.9699900049983352 50 Q14108,Q8WTV0,O15118 3 +Purine nucleoside triphosphate catabolic process 0.7555481947664864 0.7654870195806635 0.4439815929825765 1.0 0.9699900049983352 2 Q9Y3Z3 1 +Phosphatidylinositol biosynthetic process 0.3977177478386517 0.7650302002334507 0.4442535614918794 1.0 0.9700885121687318 21 O00443,Q9Y217,P37287,Q96N66,Q8TBX8 5 +Positive regulation of phosphatase activity 0.5358381305307254 0.7647919332600833 0.4443954520379685 1.0 0.9700885121687318 5 Q8IV63 1 +Regulation of receptor mediated endocytosis 0.3839802416348372 0.7629255839071034 0.4455077774508691 1.0 0.9710403374120758 23 Q15334,P05067,O00560,P50897 4 +Positive regulation of binding 0.3507197519281596 0.7628870368404148 0.4455307678255029 1.0 0.9710403374120758 53 O14786,Q09472,Q9BUN8,P19474,P56545,O75503,Q96TA1,P05067,P35611,Q9Y4G8,P09429,P62826,Q12948 13 +Regulation of dendrite development 0.408662029455252 0.7603127527958711 0.4470676607332944 1.0 0.9717268389426782 19 Q9Y4G8 1 +Muscle cell proliferation 0.3769835268521372 0.7596656728476348 0.4474544525831443 1.0 0.972045330577472 25 P09601 1 +Positive regulation of protein catabolic process 0.3476188553763041 0.7593097087688055 0.4476673110973568 1.0 0.972045330577472 54 P46379,Q9Y5X1,P04062 3 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.370762146229729 0.7587555278456214 0.4479988133462789 1.0 0.972090194580159 43 Q6PIU2,Q09472,Q93062,Q9Y3F4,Q9UIQ6,Q9Y4E8,P08670,Q92896,Q96AC1,O00560,Q53EL6,P53999,Q9UNH7 13 +Negative regulation of cell matrix adhesion 0.5121915046127866 0.7582255731618049 0.4483159542560533 1.0 0.9724466760917188 6 Q9P258 1 +Regulation of transporter activity 0.3731722478150296 0.7569844756809365 0.4490591632327556 1.0 0.973395024356658 41 P08183,Q12955,Q96GC9,Q15334,P05067,O43865,P78417,P42858 8 +Bile acid metabolic process 0.489284747262188 0.7565463066456225 0.4493217197799213 1.0 0.9736324186784262 8 P22059,O15118 2 +Skeletal system morphogenesis 0.4023684174575722 0.7561073167743334 0.4495848554780122 1.0 0.9738709058737192 20 O95470,P16435,O75844,Q7Z3C6 4 +Imp biosynthetic process 0.4887284034305981 0.7540501719409948 0.4508190957725129 1.0 0.9745535464847866 8 Q06203,P22102 2 +Regulation of steroid biosynthetic process 0.468106393105106 0.7506842994092598 0.452842674193183 1.0 0.9755755473625928 9 Q9UHI6,P16435 2 +Replicative senescence 0.5955652531640494 0.7506838370826009 0.4528429524980224 1.0 0.9755755473625928 4 Q13315 1 +Mitotic g1 s transition checkpoint signaling 0.4872863249357049 0.747586218612847 0.4547097798889201 1.0 0.9756914628068374 8 Q13315,P15927 2 +Negative regulation of defense response 0.3752221520658811 0.7471855822466454 0.4549515458126554 1.0 0.9756914628068374 25 Q9Y3Z3,P28070,P04062,O43657,Q9Y4E8 5 +Peripheral nervous system development 0.4359407155498542 0.746528004160733 0.4553485213354888 1.0 0.9756914628068374 13 Q9NR77,Q9UPY3,P51648,Q16880 4 +Nucleotide transport 0.4301260894330621 0.7455802714273376 0.4559210041852377 1.0 0.9756914628068374 14 Q9BSK2,Q8TB61,Q9H2D1 3 +Reactive oxygen species metabolic process 0.375488771855769 0.7455383170100601 0.4559463563226544 1.0 0.9756914628068374 37 P00374 1 +Regulation of extrinsic apoptotic signaling pathway 0.3767011878083282 0.7451796835280693 0.4561631030573652 1.0 0.9758270550272216 28 O14786,Q86WB0,P09601,Q8IWB1,P48507,P26583,P42858 7 +Response to amyloid beta 0.5086364946690572 0.7432131249289906 0.4573526583606204 1.0 0.9763185397302782 6 P05067 1 +Cellular response to amyloid beta 0.5086364946690572 0.7432131249289906 0.4573526583606204 1.0 0.9763185397302782 6 P05067 1 +Actin polymerization or depolymerization 0.3622284764576586 0.742950178586303 0.4575118443823962 1.0 0.9763185397302782 47 P52907,Q9Y5X1,Q14019,Q13045,P63000,O15145,P35080,P47755,P50552,Q9NUQ9,P07737,Q9UQB8,Q14247,P42345,Q6IBS0,P35241,O75083,Q9UEY8,Q9Y281,P35611 20 +Negative regulation of cell cycle g1 s phase transition 0.4451410017614819 0.7398691068426111 0.4593794213385171 1.0 0.9763185397302782 11 Q7Z7L1,Q13315,P15927 3 +Positive regulation of nervous system process 0.7497031061470211 0.7383060847140623 0.4603284697895273 1.0 0.9763185397302782 3 P04062 1 +Histone h4 r3 methylation 0.7479297780722165 0.7381284404579196 0.4604364026393528 1.0 0.9763185397302782 2 Q99873 1 +Oocyte maturation 0.5921604485610481 0.7380097436503276 0.4605085281684948 1.0 0.9763185397302782 4 P30153,Q8IXJ6 2 +Protein peptidyl prolyl isomerization 0.3743207052729034 0.7357315552016134 0.46189408202853 1.0 0.9763185397302782 26 Q9H2H8,Q96AY3,Q6UX04,Q13356,O00170,Q9Y680 6 +Glutathione metabolic process 0.3929915061118901 0.7345882502497056 0.4625902959759513 1.0 0.9763185397302782 21 Q16775,P78417,P48507,P00390 4 +Histone arginine methylation 0.7481776010603195 0.7332689498540345 0.4633944090436115 1.0 0.9763185397302782 3 Q86X55,Q99873 2 +Positive regulation of response to biotic stimulus 0.3748954306871991 0.732329314684395 0.4639675908922387 1.0 0.9763185397302782 35 Q15233,Q09472,Q15648,Q9BY67,P09429,Q9Y4E8,Q9NUD5 7 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.5895162604555688 0.728200734704201 0.4664907161887202 1.0 0.9763185397302782 4 Q96SZ6 1 +Uv protection 0.5893271461716857 0.7275003435494812 0.4669195049524925 1.0 0.9763185397302782 4 P18074,P39748,P19447 3 +Regulation of cytoplasmic mrna processing body assembly 0.746345589609571 0.7272318863662008 0.4670839159455631 1.0 0.9763185397302782 3 Q9NZN8 1 +Regulation of stem cell differentiation 0.4127543070784724 0.7261698485560872 0.4677346534576796 1.0 0.9763185397302782 17 Q96J02,Q08J23,Q9H2U1,Q9Y6C9,Q00534,Q96PZ0,Q12948 7 +Positive regulation of chromatin organization 0.481872346769875 0.7234014885283949 0.4694332569871282 1.0 0.9763185397302782 8 Q9Y6X9,P26358,Q15047 3 +Negative regulation of actin filament polymerization 0.4076162751816301 0.7231571468661765 0.4695833431669571 1.0 0.9763185397302782 18 P47755,Q9UEY8,P52907,P07737,Q6IBS0,Q13045,P35241,P35611,P35080 9 +V d j recombination 0.5008831453657524 0.7206433129990284 0.4711289978678106 1.0 0.9763185397302782 7 P09429,Q13315 2 +Protein localization to phagophore assembly site 0.5029515002751289 0.7193227459768005 0.471942084218748 1.0 0.9763185397302782 6 Q9Y4P8,Q7Z3C6 2 +Dna damage response signal transduction by p53 class mediator 0.4193238896422115 0.7183109301926671 0.472565592224571 1.0 0.9763185397302782 15 Q14694,P14174,O75832,P61254,Q9UM54,Q13315,O43324,O96017,O75844 9 +Regulation of dna templated transcription initiation 0.4249854709908151 0.7177766066648278 0.4728950396319491 1.0 0.9763185397302782 14 P11802,P09429,Q9H2U1,Q15648 4 +Detection of stimulus 0.4249175574697212 0.7174102229118243 0.4731210135938362 1.0 0.9763185397302782 14 Q8WTV0 1 +T cell activation involved in immune response 0.5240694278791327 0.7173235177135922 0.4731744993229307 1.0 0.9763185397302782 5 P09429 1 +Cation transport 0.4010827110903663 0.7171483172892036 0.4732825851457045 1.0 0.9763185397302782 143 P21796,O14548,Q15334,P00846,O75964,O15173,P42858,Q96ES6,Q8N4V1,Q12955,P00403,Q96NB2,P05067,Q9HD20,Q70HW3,P78417,O43865,O75844,Q4KMQ2,Q9UDW1,Q9BPX6,Q9Y6M7,Q96GC9,P21281,O43772 25 +Positive regulation of exocytosis 0.4247294731699283 0.716395666850151 0.473747069784463 1.0 0.9763185397302782 14 Q7Z460 1 +Membrane depolarization during action potential 0.7413050679032853 0.7145730251121456 0.4748729178730793 1.0 0.9763185397302782 2 Q12955 1 +Phosphatidylinositol dephosphorylation 0.5856397783686116 0.7138756261100286 0.4753040903321646 1.0 0.9763185397302782 4 Q01968,Q9Y217 2 +Phospholipid dephosphorylation 0.5856397783686116 0.7138756261100286 0.4753040903321646 1.0 0.9763185397302782 4 Q01968,Q9Y217 2 +Positive regulation of torc1 signaling 0.7422133863485728 0.7136646104310844 0.4754345947649754 1.0 0.9763185397302782 3 Q9Y4R8,Q96EE3 2 +Regulation of gene expression by genomic imprinting 0.7419344636304883 0.712751344247658 0.4759996385405427 1.0 0.9763185397302782 3 Q8NB78 1 +Exocrine system development 0.522178100208199 0.7097544418102664 0.4778564251380706 1.0 0.9763185397302782 5 O14786,Q12948 2 +Negative regulation of map kinase activity 0.497605536023737 0.7067377535862243 0.4797294633150133 1.0 0.9763185397302782 7 Q53EL6 1 +Cellular lipid catabolic process 0.3234027214199314 0.7053368699685304 0.4806006207700604 1.0 0.9763185397302782 64 Q9BWD1,Q8NHP8,P50897,Q8NCC3,P23786,Q8WTV0,P49748 7 +Regulation of cell junction assembly 0.3701231292930673 0.7037244117864828 0.481604414665294 1.0 0.9763185397302782 37 Q13641,Q7Z460,Q9Y4G8 3 +Protein k11 linked ubiquitination 0.4424986291958074 0.7031509491046655 0.4819616837436689 1.0 0.9763185397302782 10 P30260,Q13042 2 +Striated muscle cell differentiation 0.3710433087371155 0.7028995808907188 0.4821183323681319 1.0 0.9763185397302782 35 Q8IV08,Q9UGN5,Q9H7B4,Q13045,Q96TA1,Q9H4M9,Q16527,O75844 8 +Pyrimidine ribonucleotide biosynthetic process 0.4375268084576316 0.7016755681817888 0.482881512848047 1.0 0.9771285574870467 11 P17812,O75414,Q9NRF8,P30085 4 +Negative regulation of cell volume 0.7369990062934821 0.6993851864744172 0.4843113429385484 1.0 0.9793449674880402 2 Q4KMQ2 1 +Lipid modification 0.3567643900110196 0.6954513772419736 0.4867724724930056 1.0 0.9822107618720358 47 Q9BWD1,P04062,Q96N66,P16435,P23786,P49748 6 +Postreplication repair 0.4754563033100596 0.6949215883569162 0.4871044426630082 1.0 0.9822107618720358 8 P12004,P61088,P28340 3 +Steroid biosynthetic process 0.3653157119010186 0.6932112010535602 0.4881770198539237 1.0 0.9831535930074904 41 Q14534,Q15648,P16435,Q15800,Q16850,Q9UHI6,Q15392,Q14739 8 +Hormone mediated signaling pathway 0.3651472481969091 0.691849716029465 0.4890317114535261 1.0 0.9842517394075714 41 Q15648,P42785,O43251,Q9NUQ7,P32780,O15173 6 +Regulation of nucleotide biosynthetic process 0.4746808522802017 0.6914936281064178 0.4892553836270537 1.0 0.9843904967221112 8 P00403 1 +Negative regulation of intrinsic apoptotic signaling pathway 0.3699047196105379 0.6900772319052153 0.4901456203308827 1.0 0.9846696413450188 31 Q15233,P45880,P16989,Q96K76,P31689 5 +Negative regulation of cell activation 0.4197362462970104 0.6895347786215533 0.4904867949572953 1.0 0.9846696413450188 14 Q96J02,Q13315,P09429,P09601 4 +Amine transport 0.5168585940698891 0.6885612325374318 0.4910994243735249 1.0 0.9846696413450188 5 Q15042 1 +Phosphatidylinositol metabolic process 0.3728802496931965 0.6874811632188935 0.4917795670124401 1.0 0.9846696413450188 23 O00443,Q9Y217,P37287,Q96N66,Q8TBX8 5 +Nucleotide transmembrane transport 0.434651764256749 0.6873368222475551 0.491870499873384 1.0 0.9846696413450188 11 Q8TB61,Q9H2D1 2 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.3620568561192163 0.686548553632003 0.4923672575921662 1.0 0.9848705146644896 43 P46379,O00560,Q86UE8,P04062 4 +Positive regulation of hematopoietic progenitor cell differentiation 0.7338551399897644 0.6864406829990419 0.4924352573322448 1.0 0.9848705146644896 3 Q12948 1 +Collagen fibril organization 0.453867918203471 0.6842708960733406 0.493804121383208 1.0 0.9862518750956476 9 Q96AY3,Q92791,Q12948 3 +Multivesicular body organization 0.4239696490210968 0.6835811518665711 0.4942396898715833 1.0 0.9862518750956476 13 Q8WUX9,A5D8V6 2 +Negative regulation of ion transmembrane transporter activity 0.4536990794824882 0.6834897601194968 0.4942974185148339 1.0 0.9862518750956476 9 P78417 1 +Regulation of receptor binding 0.5769351217244576 0.681961222408473 0.4952634711882895 1.0 0.9864953674702248 4 P10586,O14786 2 +Localization within membrane 0.4071761236918469 0.6789150766099112 0.497191672337002 1.0 0.9872451371435728 155 A5D8V6,Q15042,Q15334,Q9Y4G8,Q13641,Q9NS69,P33176,Q8N4V1,P49458,Q12955,Q96CW1,O15118,Q9HD20,Q9HD45,O43681,Q99805,P46379,P43307,Q15629,P35613,Q9UBQ0,Q13356,O60725,Q9Y512,Q14168,O00560,P07602,Q15436,Q9NZJ7,O75915,P50542,Q9BTX1,Q9H4M9 33 +Regulation of membrane potential 0.3415139358064162 0.6761965362019782 0.4989158714613577 1.0 0.989013006838118 53 P33176,Q9BSK2,Q99808,P04062,Q12955,O75915,Q15042,Q15334,P05067,Q14168,Q9UQB8,P48507,O75844 13 +Regulation of vasculature development 0.3678223526307182 0.6761163174120881 0.4989667974138514 1.0 0.989013006838118 30 Q9NZ08,Q96TA1,P09601,Q12948 4 +Aspartate family amino acid metabolic process 0.3947570601499684 0.6757959718659686 0.4991701925427847 1.0 0.989013006838118 19 Q13126,Q9NRN7 2 +Neuron development 0.4247602012197021 0.6735437143215655 0.500601447854955 1.0 0.9901914793745786 179 P00374,Q9BVA1,Q9Y296,Q14108,O75503,Q15334,Q9Y4G8,Q13641,P33176,Q9HCE1,Q09472,Q12955,Q9NR77,P05067,Q9NQC3,Q9UQB8,P43034,P83731,Q96G23,P35613,Q9BW83,P50897,Q99873,P54802,P09429,O14949,Q13509,P04062,Q9Y6M7,Q9NZJ7,P42892,P10586,Q96TA1,Q9H4M9,Q16880,Q16739,O43251 37 +Negative regulation of cell differentiation 0.3257677154334446 0.6724423021651182 0.5013021600498964 1.0 0.9901914793745786 69 Q9UPY3,P09429,Q9NP50,Q15648,Q99873,Q15022,P26358,Q00534,Q8N4Q0,Q9Y4G8,P05067,Q9NQC3,Q96AC1,Q53EL6,Q96G23,Q9P258 16 +Inner cell mass cell proliferation 0.5127365620711807 0.6722400770584126 0.501430870946197 1.0 0.9901914793745786 5 P61201,O14757,Q9BRT9 3 +Glycerophospholipid metabolic process 0.3384820622056941 0.6720502517637509 0.5015517056144154 1.0 0.9901914793745786 54 O00443,P37287,Q9Y217,Q96N66,Q8N2K0,P35790,Q8NCC3,Q99943,Q13315,Q9NPH0,Q8WTV0,Q8TBX8,P43034,Q8WUK0 14 +Leukotriene biosynthetic process 0.7287181185823175 0.6704650129889104 0.5025614025558953 1.0 0.990795055178372 2 P09960 1 +Lung epithelium development 0.5119028784203128 0.6689502979070256 0.5035271835151485 1.0 0.9908567712723088 5 P09960 1 +Positive regulation of cell killing 0.4884414831524687 0.668140500020782 0.5040439116321891 1.0 0.9908659013257538 7 P15151,Q9BY67 2 +Regulation of leukocyte mediated cytotoxicity 0.4884414831524685 0.6681405000207813 0.5040439116321895 1.0 0.9908659013257538 7 P15151,Q9BY67 2 +Negative regulation of telomere capping 0.5113767106017345 0.6668759777432886 0.5048513564127184 1.0 0.9908659013257538 5 Q13315 1 +Organic hydroxy compound metabolic process 0.3601105818093115 0.666610687411406 0.5050208406840873 1.0 0.9908659013257538 103 P00374,Q15648,Q14534,P04062,O15118,P16435,Q15800,Q16775,Q16850,Q8WTV0,Q15392,Q9Y4G8,P05067,P49748,O00764 15 +Positive regulation of response to wounding 0.4347537100904739 0.6655238660034317 0.5057154839219524 1.0 0.9908659013257538 10 Q96AC1,Q4KMQ2,P42345,Q16625 4 +Negative regulation of intracellular protein transport 0.4492696273813359 0.6630556577495832 0.5072949084307847 1.0 0.9911913086492536 9 Q9GZP9 1 +Cytokinetic process 0.405717041704083 0.6628348122090337 0.5074363552767398 1.0 0.9911913086492536 16 Q9Y5X1 1 +Regulation of anatomical structure size 0.3447292825083958 0.661771473535888 0.5081176907634912 1.0 0.9914854739989956 88 O00443,Q9Y5X1,Q14019,Q13045,O15145,P47755,O14786,P50552,Q96CW1,Q9HB40,P07737,Q9NQC3,Q9UQB8,P43034,Q12948,P42345,Q4KMQ2,P42892,P35611,P48507 20 +Regulation of mitochondrial fusion 0.5711282481726947 0.6608781827719976 0.5086904385724333 1.0 0.9914854739989956 4 Q9Y6C9 1 +Positive regulation of actin filament bundle assembly 0.4292840171945208 0.6606990336093485 0.5088053436786004 1.0 0.9914854739989956 11 O14786,P42345,P07737,P63000,Q96AC1 5 +Lipid biosynthetic process 0.384488597130226 0.6606548084410563 0.5088337115068722 1.0 0.9914854739989956 130 O00443,P37287,P11802,P35790,Q8NCC3,Q9NZ01,Q9NPH0,Q16850,Q8WTV0,Q14739,O95864,Q86YN1,Q8NBX0,P16435,Q96G23,Q99805,Q9Y217,Q15800,Q99943,Q9UHI6,P49748,O00154,Q13510,Q15648,Q14534,P04062,Q96N66,O95470,Q8TBX8,Q15392,Q16880,Q16739,Q8WUK0 33 +Regulation of nucleotide metabolic process 0.4049498978900402 0.6585431617751465 0.5101891719205749 1.0 0.9916537450289372 16 P00403,P05067,Q09472 3 +Cellular response to peptide 0.3211741710942568 0.6583787517069112 0.5102947854997835 1.0 0.9916537450289372 66 Q9BSK2,O00443,P43490,P11802,Q92572,P16435,P05067,Q8TBX8,Q9UQB8,O43865 10 +Sodium ion transport 0.362390836804496 0.656972476450681 0.5111986141712319 1.0 0.992313156942124 25 Q12955,Q4KMQ2,Q9Y6M7,O43865 4 +Cell part morphogenesis 0.3760513439748054 0.6566024157078664 0.5114365951933233 1.0 0.992313156942124 121 Q9BVA1,P78559,Q15334,Q9Y4G8,Q13641,Q9BPU6,P33176,Q9HCE1,O14786,P50552,Q12955,P46821,P05067,Q9NQC3,Q9UQB8,P43034,O60678,P83731,Q9Y5P4,P35613,O60749,Q9H2U1,Q8TB37,Q13509,Q9UPY3,P42892,Q96TA1,Q16880,O43251,Q9Y263 30 +Regulation of neuronal synaptic plasticity 0.4661854379837061 0.654154213566712 0.5130124566391383 1.0 0.9929032212284072 8 P05067,Q15042 2 +Cardiac chamber development 0.4001632942385693 0.6536586856921008 0.5133317260922281 1.0 0.9929032212284072 17 Q15648,O75844 2 +Negative regulation of transporter activity 0.4322643669603735 0.6535080864838251 0.5134287779142748 1.0 0.9929032212284072 10 P78417 1 +Positive regulation of muscle cell differentiation 0.4845502359165168 0.6518863777666513 0.514474473298024 1.0 0.99293072982549 7 Q9UGN5,Q96TA1 2 +L glutamate transmembrane transport 0.483924438115242 0.6492803253231968 0.5161572003761066 1.0 0.994787067189576 7 O75915,O60831,Q9H936,Q9UPY5 4 +Negative regulation of circadian rhythm 0.7210997018880481 0.6442102904618657 0.5194390788740404 1.0 0.997535758228204 2 P23246 1 +Cellular response to gamma radiation 0.4258990443292471 0.6439957017414207 0.5195782212337252 1.0 0.997535758228204 11 O75844 1 +Neurotransmitter gated ion channel clustering 0.7188220527075195 0.6382685610807864 0.5232988736423225 1.0 1.0 3 Q15334 1 +Voluntary musculoskeletal movement 0.564688236466585 0.63770409232001 0.5236663211254471 1.0 1.0 4 P42345 1 +Regulation of nervous system development 0.3166108610414904 0.632591746887043 0.527000277987782 1.0 1.0 60 Q13641,Q9Y4G8,Q9UQB8 3 +Arf protein signal transduction 0.562810739144837 0.6309910330900838 0.5280463874994592 1.0 1.0 4 Q92538,Q8N6T3,Q15555 3 +Positive regulation of protein kinase b signaling 0.3961474300578164 0.6307630470418327 0.5281954685559631 1.0 1.0 17 Q13641 1 +Sulfur compound metabolic process 0.3545942333080469 0.6295350498472594 0.5289988298330766 1.0 1.0 101 Q13126,P00390,P50897,Q9UBX3,P16278,Q8TB61,Q9NZ01,Q16775,O60725,Q8NCH0,P78417,P48507,O43865 13 +Maintenance of apical basal cell polarity 0.7167936402782438 0.6295276314196367 0.5290036848904398 1.0 1.0 2 Q8WUM4 1 +Alpha amino acid metabolic process 0.3258551953788776 0.6280573689429567 0.529966358870329 1.0 1.0 73 Q13126,P00374,O15382,O60725,Q9NRF8 5 +Axo dendritic transport 0.3589791769572886 0.6274933954180003 0.5303358641329816 1.0 1.0 26 P33176,Q92572,P05067,Q14168,P43034,Q15554 6 +Positive regulation of nuclease activity 0.7153744201458003 0.62737473481665 0.5304136250709652 1.0 1.0 3 P12004,P26583 2 +Regulation of t circle formation 0.7157999337529042 0.6261559457313945 0.5312126597162572 1.0 1.0 2 Q15554 1 +Anatomical structure maturation 0.3585569749901985 0.6245457501754252 0.5322692345369981 1.0 1.0 26 O75503,P05067,Q9NZJ7,P04062 4 +Notch signaling pathway 0.3987619290222525 0.6240817498791243 0.5325738986812376 1.0 1.0 16 Q15334,Q96TA1,P05067,Q92542,Q00534,Q12948 6 +Positive regulation of deoxyribonuclease activity 0.7151374627360114 0.6239116684140183 0.53268559684075 1.0 1.0 2 P12004 1 +Positive regulation of activated t cell proliferation 0.7151374627360116 0.6239116684140183 0.53268559684075 1.0 1.0 2 P09429 1 +Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.7151374627360114 0.6239116684140183 0.53268559684075 1.0 1.0 2 P61254 1 +Regulation of amino acid transport 0.560284210607127 0.6219890641031159 0.5339490589422855 1.0 1.0 4 Q15042 1 +Transcription initiation from rna polymerase ii promoter 0.3752488544637726 0.6216976702806589 0.53414068383025 1.0 1.0 21 Q15648,P11802,Q9H2U1,O15514,P09429,P53999 6 +T cell homeostasis 0.5596130058123339 0.6196037922541673 0.535518669442689 1.0 1.0 4 P62753 1 +Negative regulation of inflammatory response 0.4206454932544354 0.618228201634776 0.536424922475149 1.0 1.0 11 P28070,P04062 2 +Chaperone mediated protein complex assembly 0.41601671044876 0.6176595492903506 0.5367997817077732 1.0 1.0 12 P07900,P78371,Q15185,O15212,Q9Y375 5 +Response to bacterium 0.3352177006997117 0.617475812630046 0.536920930231862 1.0 1.0 53 Q53EL6,Q9NZ08,Q8WTV0,Q9UQB8 4 +Somatic diversification of immune receptors 0.3554091891202343 0.6151238349465953 0.5384729424739483 1.0 1.0 24 Q9Y3Z3,Q9UQ84,P02786,Q9NQT5,Q13315,P52701,P09429 7 +Presynapse organization 0.4977868459431056 0.6138616189087546 0.539306774659414 1.0 1.0 5 P05067 1 +Negative regulation of phosphatidylinositol 3 kinase signaling 0.7121563431599929 0.6138475924567894 0.5393160443025471 1.0 1.0 2 O95630 1 +Cellular response to fatty acid 0.4772471489870885 0.6134024315570544 0.539610278665823 1.0 1.0 6 P11802,Q15120,P50416 3 +Cd4 positive alpha beta t cell differentiation 0.7109141856580844 0.6133713662550895 0.5396308146445432 1.0 1.0 3 P09429 1 +T cell differentiation involved in immune response 0.7109141856580844 0.6133713662550895 0.5396308146445432 1.0 1.0 3 P09429 1 +T helper 1 type immune response 0.7109141856580844 0.6133713662550895 0.5396308146445432 1.0 1.0 3 P09429 1 +T helper 1 cell differentiation 0.7109141856580844 0.6133713662550895 0.5396308146445432 1.0 1.0 3 P09429 1 +Xmp metabolic process 0.4752315492188947 0.613321173968312 0.5396639955040503 1.0 1.0 7 Q06203,P22102 2 +Regulation of cell killing 0.4567181482885791 0.6130502130658412 0.5398431385878248 1.0 1.0 8 P15151,Q9BY67 2 +Regulation of ligase activity 0.5575488490695717 0.6122849857912265 0.540349221603851 1.0 1.0 4 P48507 1 +Positive regulation of attachment of spindle microtubules to kinetochore 0.5567974470116452 0.6096270617318218 0.5421088809213186 1.0 1.0 4 Q9P258,P14635 2 +Maternal process involved in female pregnancy 0.475966937386312 0.6082298727123736 0.5430350245331685 1.0 1.0 6 Q15648 1 +Cardiac muscle contraction 0.3921031834046186 0.607834717608701 0.5432971007492753 1.0 1.0 17 P78417 1 +Cellular component morphogenesis 0.3835832581998475 0.6065141818848323 0.5441733678727538 1.0 1.0 135 Q9BVA1,P78559,Q15334,Q13045,Q9Y4G8,Q13641,Q9BPU6,Q16527,P33176,Q9HCE1,O14786,P50552,Q12955,Q7Z460,P46821,Q9NR77,P05067,Q9NQC3,Q9UQB8,P43034,O60678,P83731,Q9Y5P4,P35613,O60749,Q9H2U1,Q8TB37,Q13509,Q9UPY3,P42892,Q96TA1,Q16880,O43251,Q9Y263 34 +Glycolipid catabolic process 0.4750888729363417 0.6046884280282648 0.5453860385067002 1.0 1.0 6 P04066,P04062,P06280 3 +T cell proliferation 0.3777413787495877 0.6036158160067266 0.5460990951194122 1.0 1.0 20 Q96J02,P49366,Q9BY67,P02786,Q92542,P09429 6 +Fatty acid homeostasis 0.7077159573257669 0.6033944452836004 0.5462463166114058 1.0 1.0 3 P28340 1 +Histone h3 k4 demethylation 0.5549989470896184 0.6032790921222458 0.5463230394484921 1.0 1.0 4 Q8NB78 1 +Gmp biosynthetic process 0.4166812179996518 0.5989186938043015 0.5492271048338833 1.0 1.0 11 P22102,P12268,P30566,P49915,Q06203 5 +Dna strand elongation involved in dna replication 0.4166466199123942 0.598750703486099 0.5493391400774441 1.0 1.0 11 P12004,Q07864,Q9NRF9,P40938 4 +Protein quality control for misfolded or incompletely synthesized proteins 0.4074415590344754 0.5981558337046881 0.5497359581846175 1.0 1.0 13 P46379,Q9BUN8,Q16740,Q9HCN8 4 +Organ growth 0.3764322803027401 0.5956489225650307 0.5514097868693153 1.0 1.0 20 P07602,P16989,Q9NZJ7,P16435,O75844,Q12948 6 +Negative regulation of chemotaxis 0.4728280532777871 0.5955939188547554 0.5514465401264548 1.0 1.0 6 O14786,P14174 2 +Negative regulation of cytoskeleton organization 0.3520883553360996 0.5954425371453448 0.551547698990333 1.0 1.0 42 P63167,P47755,Q9P1Y5,Q92974,Q9UEY8,P52907,P04350,Q7Z460,P46821,P07737,Q6IBS0,Q13045,P35241,P35611,P29372,P35080 16 +Regulation of entry of bacterium into host cell 0.7050994540539783 0.5952731168388603 0.5516609227260791 1.0 1.0 3 Q9BTY2 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4515263234007552 0.5907600285402529 0.5546812205854101 1.0 1.0 8 Q96K76,P61254,P23396 3 +Axon ensheathment in central nervous system 0.7052003974826164 0.5905943112215885 0.5547922774456162 1.0 1.0 2 Q92542 1 +Inositol phosphate catabolic process 0.7034459907223299 0.5901602658339897 0.5550832081411676 1.0 1.0 3 Q01968,Q10713 2 +Ribose phosphate biosynthetic process 0.3306492950730562 0.5901549653981055 0.5550867613628254 1.0 1.0 81 P50897,Q8TB61,O43252,O75414,Q9NZ01,P00403,Q9NRF8,P00846,O75964,O00154 10 +Skin epidermis development 0.4187610759609718 0.589078255075914 0.5558087796131013 1.0 1.0 10 O75844 1 +Epithelial cell differentiation involved in prostate gland development 0.7028957719265647 0.5884622291122733 0.5562220791286858 1.0 1.0 3 P07602 1 +Regulation of peptidyl serine phosphorylation 0.3800717813068547 0.5880711789473738 0.5564845173314787 1.0 1.0 19 P14174,P02786,P07900,P05067,P63244,Q9H7B4,P35080 7 +Ribonucleoside triphosphate biosynthetic process 0.3556025322655503 0.5880381955300225 0.5565066556376812 1.0 1.0 30 P00846,O75964,Q9NRF8 3 +Regulation of intracellular estrogen receptor signaling pathway 0.4003840184069414 0.586991171164794 0.5572096362746062 1.0 1.0 14 Q15648,Q86X55,Q9NUQ7,Q13309,Q9NZN8 5 +Positive regulation of myelination 0.7038754554488305 0.5862025282649239 0.5577394228928081 1.0 1.0 2 Q9UPY3 1 +Positive regulation of fibroblast proliferation 0.4685798476354754 0.5861299460745936 0.5577881937427875 1.0 1.0 7 P11802 1 +Regulation of gtpase activity 0.3341551430632752 0.5860295580037115 0.5578556518852247 1.0 1.0 52 Q15042,Q9Y5X1,Q4VCS5,Q9Y4G8,P43034,Q66K14,Q9P258 7 +Regulation of epidermal growth factor activated receptor activity 0.4904759434751815 0.585824970611494 0.5579931415153077 1.0 1.0 5 P05067 1 +Nucleoside phosphate catabolic process 0.3917874369367693 0.5856028814962667 0.5581424115480038 1.0 1.0 16 O43598,Q9Y3Z3 2 +Amyloid precursor protein catabolic process 0.4000948405216166 0.5854805840494614 0.5582246181201944 1.0 1.0 14 Q9NQC3,O95197,Q15392 3 +Regulation of telomere capping 0.4179273004069193 0.5851449848511842 0.5584502332770738 1.0 1.0 10 Q93009,Q96T60,Q13315,Q15554 4 +Cytoplasmic pattern recognition receptor signaling pathway 0.3998758217074243 0.5843369626673437 0.5589936286270332 1.0 1.0 14 O43657,Q9Y4E8 2 +Lymphocyte activation 0.3300369583915181 0.5838027831587742 0.5593530055535001 1.0 1.0 81 Q96J02,P46379,Q9UQ84,P49366,Q09472,P04062,P24390,Q9BY67,O96005,P42345,Q9NQT5,Q13315,Q00534,P78318,P52701,P09429 16 +Cell cycle g1 s phase transition 0.3338000223039772 0.5827995454989561 0.5600282509697334 1.0 1.0 52 Q7Z7L1,Q7L2J0,P11802,O00743,P61254,Q13315,Q07864,Q13309,Q96DY7,Q00534,Q07666,Q15058,Q96HY6,P35241,P15927,Q13617 16 +Ceramide catabolic process 0.4696255940841829 0.5827719081246882 0.5600468583453844 1.0 1.0 6 Q13510,P04062,P06280 3 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.489649831623921 0.5826798392401847 0.5601088475943776 1.0 1.0 5 Q5J8M3,Q8N4V1 2 +Positive regulation of chemokine c x c motif ligand 2 production 0.7025505134150452 0.5818229855326402 0.5606859198439502 1.0 1.0 2 P09429 1 +Chemokine c x c motif ligand 2 production 0.7025505134150452 0.5818229855326402 0.5606859198439502 1.0 1.0 2 P09429 1 +Positive regulation of b cell proliferation 0.7025505134150447 0.5818229855326389 0.5606859198439511 1.0 1.0 2 P02786 1 +Negative regulation of neuron death 0.3530311080767952 0.5814846285025596 0.5609138751784832 1.0 1.0 39 O95630,O14786,Q15233,Q9UPY5,P50897,Q9UGN5,P04062,P09601,P48681,P43246,P48507,Q15058,Q9UNH7 13 +Enzyme linked receptor protein signaling pathway 0.3585187412542394 0.5809854148209593 0.561250283541797 1.0 1.0 110 O00443,P43490,Q93062,Q09472,P11802,Q9UIQ6,O95470,P10586,Q96TA1,Q8TBX8,Q9Y4G8,Q9NQC3,Q9UQB8,Q53EL6,O00560,Q9Y4E8 16 +Cellular response to virus 0.378840577298683 0.5808036582004527 0.561372789290536 1.0 1.0 19 Q92538,O15111,P63241,Q92890,O43657,Q9Y4E8,Q9NUD5 7 +Cellular response to insulin stimulus 0.3433262808830909 0.5800488640723084 0.5618816662937742 1.0 1.0 47 Q9BSK2,O00443,P43490,P11802,Q8TBX8,Q9UQB8 6 +Endoplasmic reticulum to cytosol transport 0.4166465598406447 0.5791141664108277 0.5625121418445072 1.0 1.0 10 Q9GZP9,Q9BUN8,Q8TCT9,Q92890 4 +Negative regulation of nitric oxide metabolic process 0.699138502319433 0.5769122591430645 0.5639987287136239 1.0 1.0 3 P06280,Q92945 2 +Positive regulation of dephosphorylation 0.3933650643965698 0.5768290788259723 0.5640549238105184 1.0 1.0 15 P63167,Q8IV63,Q86XL3,P04062 4 +Regulation of glial cell differentiation 0.4301393214855932 0.5762662752794905 0.5644352143937867 1.0 1.0 9 Q9UPY3,O14744,P42345,P06493 4 +Regulation of actomyosin structure organization 0.3731200913440726 0.5755675132710121 0.5649075447789 1.0 1.0 20 P63167,O14786,P42345,Q7Z460,P07737,P63000,Q96AC1 7 +Negative regulation of macrophage chemotaxis 0.7005631003643656 0.575276865750702 0.565104064848112 1.0 1.0 2 P14174 1 +Negative regulation of macrophage migration 0.7005631003643656 0.575276865750702 0.565104064848112 1.0 1.0 2 P14174 1 +Positive regulation of cell projection organization 0.3130869631183751 0.573372688269362 0.5663923786311469 1.0 1.0 66 O14786,Q09472,P42345,Q9H2U1,P46821,P07737,Q14108,Q15334,Q16625,Q6IBS0,Q9Y4G8,Q9UQB8,P43034,Q9H4M9,P42858 15 +Extracellular vesicle biogenesis 0.4472072492377779 0.5723635664267991 0.5670756932814074 1.0 1.0 8 O00560,Q8WUM4 2 +Positive regulation of telomere maintenance via telomere lengthening 0.3770683372497679 0.5703689579397931 0.5684274791946518 1.0 1.0 19 Q99832,Q96T60,P22626,Q9H2U1,P78371,Q13315,P27361 7 +Regulation of glutamine family amino acid metabolic process 0.6989069228221332 0.5698432676070747 0.5687840063710137 1.0 1.0 2 Q9UPY5 1 +Nitric oxide mediated signal transduction 0.6989069228221332 0.5698432676070747 0.5687840063710137 1.0 1.0 2 O00330 1 +Negative regulation of cell substrate junction organization 0.545395910458739 0.5697270229790873 0.5688628587846654 1.0 1.0 4 Q9P258 1 +Regulation of cytosolic calcium ion concentration 0.3668945928052827 0.5694994142198881 0.5690172681393459 1.0 1.0 21 Q15334,P78417,P42858 3 +Regulation of fatty acid metabolic process 0.4144673759885308 0.5688838761009595 0.5694349482890735 1.0 1.0 10 P49748 1 +Protein polyubiquitination 0.3401807682755721 0.5678504981170074 0.5701364871526526 1.0 1.0 48 Q96J02,O75150,Q96FW1,Q9UIQ6,P30260,P14373,Q13042,P19474,P55786,Q13356,Q13309,Q15386,P52888,Q9Y263 14 +Striated muscle contraction 0.3717566340149182 0.5673338436260417 0.5704873876004379 1.0 1.0 20 P78417 1 +Cellular response to peptide hormone stimulus 0.3192449112119738 0.5660810099615878 0.5713387119075488 1.0 1.0 57 O00443,P43490,P11802,P16435,Q8TBX8,Q9UQB8,O43865 7 +Regulation of mitochondrial atp synthesis coupled electron transport 0.6944996686547372 0.5627637999724436 0.5735957335215485 1.0 1.0 3 P06493,P14635 2 +Positive regulation of lipid catabolic process 0.6959258032461146 0.5601127855237802 0.5754025100718057 1.0 1.0 2 P50416 1 +Dna methylation dependent heterochromatin assembly 0.4265077540482646 0.5600947056022708 0.5754148415174711 1.0 1.0 9 Q9Y6X9,P26358,Q15047 3 +Cristae formation 0.4438469823314714 0.5581481139840271 0.5767432480373011 1.0 1.0 8 Q9Y512 1 +Regulation of post translational protein modification 0.6929432952562007 0.5580450738720957 0.5768136056571858 1.0 1.0 3 O75718 1 +Regulated exocytosis 0.3513227891101044 0.5532527776659271 0.5800903317879524 1.0 1.0 33 P09601,Q15042,O43760,P56545,Q68EM7,Q9UNH7 6 +Sodium ion transmembrane transport 0.3693766348587424 0.5530093595358234 0.5802570012064767 1.0 1.0 20 Q12955,Q4KMQ2,Q9Y6M7 3 +Mammary gland development 0.3737740997722485 0.5510590483014245 0.5815931970091206 1.0 1.0 19 P00403,Q13505,Q15648,Q9NQC3 4 +Early endosome to golgi transport 0.4616004830241115 0.5509678780706613 0.5816556946715887 1.0 1.0 6 O15260 1 +Glycoprotein biosynthetic process 0.3380115368815863 0.5492648458541842 0.5828237086781085 1.0 1.0 48 O60502,Q9Y5P6,Q86YN1,O15118,Q6ZXV5,Q8NCH0,Q2TAA5,Q7LGA3 8 +Cytoskeleton dependent intracellular transport 0.3146444809111831 0.549238658951639 0.5828416773409333 1.0 1.0 58 P33176,Q9P1Y5,Q8NCM8,Q9BW83,O94901,P78559,Q92572,P46821,P62820,P07437,P05067,Q15154,Q14168,P43034,Q15554,P42858 16 +Forebrain development 0.3063646341868354 0.5488572420262642 0.5831034234242796 1.0 1.0 62 P63167,Q8NCM8,Q9Y6A5,Q9UPY5,Q15042,Q00534,Q9Y4G8,P62826,O14786,O94901,P22102,Q13144,P05067,Q15058,Q9NQC3,P43034,O14949,Q9H0D6,Q96N66,P50542 20 +Nuclear membrane reassembly 0.4235027768844949 0.5467952784499656 0.5845193872368413 1.0 1.0 9 Q86XL3 1 +Lens development in camera type eye 0.4602247899371462 0.5455650157712185 0.5853649777471668 1.0 1.0 6 Q15648,P08670 2 +Pigment granule localization 0.4794000988263883 0.5440696954296711 0.5863935133703155 1.0 1.0 5 Q96AX1 1 +Positive regulation of chemotaxis 0.3767810973675782 0.5436565954741491 0.5866778061633833 1.0 1.0 18 Q13641,Q4KMQ2 2 +Oxidative phosphorylation 0.3046534899601098 0.5424911954572423 0.5874801711891791 1.0 1.0 61 O14949,Q9Y6M9,P14406,O14548,P03886,P00403,P00846,O75964,Q9UDW1 9 +Neurotransmitter secretion 0.3802605284237069 0.5415356768498689 0.5881384138017351 1.0 1.0 17 P50897,Q15042,Q06787,P56545,P16615,P35080 6 +Nuclear pore organization 0.4003904435483323 0.5403918729242303 0.5889268113531458 1.0 1.0 12 Q9BTX1 1 +Positive regulation by host of viral genome replication 0.4781167108753256 0.5392912062263413 0.5896859356529471 1.0 1.0 5 Q9H1E3,Q9P0L0,P11142,Q9H6S0 4 +Regulation of notch signaling pathway 0.4579799410157592 0.536780794610138 0.5914190393091892 1.0 1.0 6 Q96TA1 1 +Cell projection assembly 0.3355716105273622 0.5355757108354924 0.5922518192336461 1.0 1.0 91 P63167,Q8NCM8,Q92538,Q06787,Q01968,A6NIH7,P63000,Q9Y4G8,Q15019,P35080,P42858,Q9P258,O14786,P07737,Q9NR77,Q16625,Q9NT62,Q15154,P42345,Q8WWQ0,Q6IBS0,P62820,P35241,O00560,Q4KMQ2,Q96FJ2,Q66K14,Q9H4M9,Q9Y277 29 +Positive regulation of dna binding 0.3791362842359002 0.5353136645665267 0.5924329789813099 1.0 1.0 17 Q09472,Q96TA1,P09429,Q96HY6,P26583,Q12948 6 +Regulation of microtubule polymerization 0.361204800194125 0.5343820315367437 0.5930772480861832 1.0 1.0 21 P04350,Q7Z460,P46821,Q16625,P63000 5 +Negative regulation of alpha beta t cell activation 0.6850403792690145 0.5343101248152814 0.5931269883889532 1.0 1.0 3 P09429 1 +Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest 0.5349004222794473 0.5337608175780622 0.5935070257672155 1.0 1.0 4 Q13315 1 +Regulation of establishment of protein localization to mitochondrion 0.3899177318403263 0.532796145802909 0.5941747021266028 1.0 1.0 14 O14737,P49257,P55786,P31689,Q9H300,Q9UBE0 6 +Atp biosynthetic process 0.360783928352775 0.5317996564000587 0.5948647607774258 1.0 1.0 21 P00846,O75964 2 +Regulation of cell aging 0.4024602206278255 0.5307178734384064 0.5956142984081254 1.0 1.0 11 Q00534,O75844 2 +Regulation of fat cell differentiation 0.4023824792070504 0.5303500420071134 0.5958692567761654 1.0 1.0 11 Q86X55,Q96AC1,Q8N4Q0 3 +Mitochondrial depolarization 0.4753927959747831 0.5291923365342494 0.5966720323058543 1.0 1.0 5 Q9UII2,P48507 2 +Purine nucleotide salvage 0.533467828435852 0.528912151880942 0.5968663917730792 1.0 1.0 4 P30566,P55263 2 +Purine ribonucleotide salvage 0.533467828435852 0.528912151880942 0.5968663917730792 1.0 1.0 4 P30566,P55263 2 +Amp salvage 0.533467828435852 0.528912151880942 0.5968663917730792 1.0 1.0 4 P30566,P55263 2 +Muscle tissue development 0.3338098787615592 0.5285020552965105 0.5971509209334871 1.0 1.0 49 Q15648,Q09472,Q99873,Q9UGN5,P16989,P49454,O94966,Q96TA1,O75844,P60660,Q16527,Q12948 12 +Tubulin complex assembly 0.4553897180762752 0.526695708248938 0.5984049164406717 1.0 1.0 6 Q9BTW9,Q15813,P17987,Q15814,O75347 5 +Positive regulation of ruffle assembly 0.68247030307983 0.5266747733340882 0.5984194568017902 1.0 1.0 3 P07737 1 +Regulation of cholesterol biosynthetic process 0.5321823358253182 0.5245741975253408 0.5998792276443405 1.0 1.0 4 P16435 1 +Regulation of alcohol biosynthetic process 0.5321823358253182 0.5245741975253408 0.5998792276443405 1.0 1.0 4 P16435 1 +Xenophagy 0.681742972867611 0.5245215820451693 0.5999158128440543 1.0 1.0 3 Q9Y4P8 1 +Regulation of phospholipase activity 0.4357246263311709 0.5241604905127928 0.6001669183920628 1.0 1.0 8 P40616,P50897 2 +Regulation of cellular carbohydrate metabolic process 0.3419979937755415 0.5241009686886785 0.6002083148439326 1.0 1.0 24 Q14108 1 +Negative regulation of oxidative stress induced neuron death 0.473732900035995 0.5230676097747884 0.6009272047448826 1.0 1.0 5 Q15233,Q9UPY5 2 +Mammary gland epithelium development 0.452358833288363 0.521153090971714 0.6022601290317966 1.0 1.0 7 Q15648 1 +Regulation of cellular response to heat 0.4348161668086869 0.5203935482750685 0.6027893059113512 1.0 1.0 8 Q13315,Q09472 2 +Regulation of gliogenesis 0.3994981661890855 0.5167444896732778 0.6053345347044699 1.0 1.0 11 Q96G23,P42345 2 +Cytoplasmic translational initiation 0.36777382024762 0.51619415697457 0.6057188108254437 1.0 1.0 19 Q9NR50,P41214,P42345,Q9ULC4,P55010,Q15056 6 +Establishment of mitotic spindle localization 0.3993707350624549 0.5161452757495277 0.6057529479823371 1.0 1.0 11 P43034,Q7Z460,P42858 3 +Response to nutrient 0.3449828590465568 0.5129622796699741 0.6079777066783771 1.0 1.0 30 Q15648,P42345,P35573,P02786,P09601,P16435,P53985,P48507 8 +Regulation of g0 to g1 transition 0.6777602638421372 0.5127915815872786 0.6080971191527755 1.0 1.0 3 Q15648 1 +G0 to g1 transition 0.6777602638421372 0.5127915815872786 0.6080971191527755 1.0 1.0 3 Q15648 1 +Protein localization to plasma membrane 0.3071828843336525 0.5121116440382835 0.6085728756960371 1.0 1.0 66 P35613,P33176,Q15436,Q12955,O75915,Q13356,Q9Y4G8,Q13641,Q9H4M9 9 +Pyrimidine ribonucleoside triphosphate metabolic process 0.4020174205240959 0.5112461875399797 0.6091786806519379 1.0 1.0 10 P17812,O75414,Q9NRF8 3 +Regulation of cell maturation 0.680026498840683 0.5093524053238043 0.610505231004502 1.0 1.0 2 Q15058 1 +Regulation of lipid metabolic process 0.3332848555578288 0.509046520509158 0.6107196163780149 1.0 1.0 48 Q13510,P07602,Q15120,Q05639,Q96N66,P11802,Q9NZJ7,P16435,Q8WTV0,Q9H6K4,Q9UHI6,Q8TBX8,P49748,O60678,Q96G23,O75844 16 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.3800930747524183 0.5066584901523069 0.6123944608277587 1.0 1.0 15 P46379,Q09472 2 +Cytokine production 0.3243722088299829 0.5042630505229883 0.6140765388540923 1.0 1.0 83 Q96J02,P09601,P07900,P63000,Q9BY67,P19474,P05067,Q53EL6,P26583,Q8IV08,Q9H2U1,Q99943,P62820,O15111,P09429,Q9NUD5,Q9UPY3,P04062,P14373,O14802,Q92890 21 +Retina development in camera type eye 0.3731237671355274 0.5022726692986307 0.615475731578806 1.0 1.0 17 Q9H0D6,Q15648,P54802,P83731 4 +Developmental maturation 0.3434990403790771 0.5008223478043731 0.616496156247111 1.0 1.0 37 Q9BXS5,Q08J23,P04062,Q9NZJ7,O75503,Q15334,P05067 7 +Cellular response to heat 0.3393885191839292 0.4994974210985756 0.6174290031144152 1.0 1.0 25 Q13315,O15514,P09601,Q09472 4 +Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization 0.6763829082477717 0.4980022353832314 0.6184824666122921 1.0 1.0 2 Q709C8 1 +Sphingosine biosynthetic process 0.5240164687565979 0.4973101447581994 0.6189703589190638 1.0 1.0 4 Q13510,P04062 2 +Regulation of map kinase activity 0.3781924707539039 0.4967587376588289 0.6193591959816491 1.0 1.0 15 Q53EL6 1 +Female meiosis chromosome segregation 0.672164325660634 0.4964866122400213 0.6195511305766535 1.0 1.0 3 Q15003 1 +Pyruvate metabolic process 0.3412794420743797 0.4963821367401835 0.6196248257786694 1.0 1.0 40 P21796,Q9BRR6 2 +Fatty acid derivative metabolic process 0.3598428433403345 0.4962899787034615 0.6196898356288583 1.0 1.0 20 Q9NZ01 1 +Protein maturation 0.3044770424087233 0.4954216124875584 0.620302541910488 1.0 1.0 65 Q9H300,Q8NCM8,Q09472,P49366,P67812,P42892,Q8TCT9,O75503,Q5JRX3,Q9NRN7,Q15392,Q92896,O75844,O00170,P55210 15 +Demethylation 0.3680429641849058 0.4944300984775631 0.6210024618057639 1.0 1.0 18 Q8NB78,Q16850 2 +Cilium organization 0.3315072117177124 0.4940273353619117 0.6212868744671849 1.0 1.0 48 P63167,Q8NCM8,Q92538,Q9BW83,Q8WWQ0,Q96FJ2,Q01968,A6NIH7,Q9NT62,P62820,Q15019,Q15154,Q66K14,Q9H4M9,P42858,Q9Y277 16 +Biomineralization 0.3820383350405508 0.4927079093706538 0.6222189882138074 1.0 1.0 14 Q4KMQ2,O75844 2 +Regulation of wound healing 0.3818652230143891 0.4918346710937097 0.622836224290306 1.0 1.0 14 P42345,Q7Z460,Q16625,Q96AC1,Q4KMQ2 5 +Regulation of protein depolymerization 0.342076316837174 0.4899326108521767 0.6241815858503439 1.0 1.0 31 P47755,Q9P1Y5,Q9UEY8,P78559,P52907,Q7Z460,P46821,P48681,Q6IBS0,Q13045,P35241,P35611,P29372,Q92974 14 +Cellular response to leucine 0.6696487740225404 0.4892258063591978 0.6246818412803523 1.0 1.0 3 Q9P2J5,P42345 2 +Dedifferentiation 0.6727393176548602 0.4867624029551629 0.626426716809307 1.0 1.0 2 Q00534 1 +Development of secondary sexual characteristics 0.6687012790466891 0.4865022505002316 0.6266111101060579 1.0 1.0 3 Q15648 1 +Negative regulation of cellular catabolic process 0.3236436849284709 0.4864000447456243 0.6266835588456012 1.0 1.0 84 P46379,P09601,O15118,P10619 4 +Ribosome disassembly 0.4632419172548172 0.4848953352872264 0.6277505914879811 1.0 1.0 5 P41214,Q9ULC4 2 +Regulation of monocyte chemotaxis 0.4444475909964545 0.4847235037123669 0.6278724917688931 1.0 1.0 6 Q4KMQ2 1 +Negative regulation of tor signaling 0.5201649464060908 0.4846320964402523 0.6279373418006888 1.0 1.0 4 Q13315 1 +Response to monosaccharide 0.3389195835918475 0.4840415664410108 0.628356369904226 1.0 1.0 27 Q9NR50,Q14232,Q15120,Q99808,O00330,P17858,P22059,P55809,Q13144,P48507,P63244,Q96RR1,P49770,P54646 14 +Estrogen biosynthetic process 0.6717456111295206 0.4837164553390046 0.6285871132813918 1.0 1.0 2 Q8NBQ5 1 +Hematopoietic progenitor cell differentiation 0.3378581060870271 0.4827309074800242 0.6292868147297757 1.0 1.0 26 Q96J02,A0AV96,Q9H2U1,Q9NPH0,Q00534,Q96PZ0,Q12948 7 +Positive regulation of epidermis development 0.4432939554715887 0.4803607664468802 0.6309708868338508 1.0 1.0 6 Q15648 1 +Positive regulation of epidermal cell differentiation 0.4432939554715887 0.4803607664468802 0.6309708868338508 1.0 1.0 6 Q15648 1 +Positive regulation of keratinocyte differentiation 0.4432939554715887 0.4803607664468802 0.6309708868338508 1.0 1.0 6 Q15648 1 +Interferon beta production 0.3916943521594803 0.4803579272174387 0.6309729053623663 1.0 1.0 11 P41440,Q7Z434,Q06124,O00571,P07900,O14802,O94826,O75955,Q9BUI4,P26583 10 +Positive regulation of interferon beta production 0.3916943521594803 0.4803579272174387 0.6309729053623663 1.0 1.0 11 P41440,Q7Z434,Q06124,O00571,P07900,O14802,O94826,O75955,Q9BUI4,P26583 10 +Pattern recognition receptor signaling pathway 0.3374884817898468 0.4802541471532606 0.6310466888966979 1.0 1.0 26 Q9NPR9,Q9NQC3,O43657,Q9Y4E8,Q9NUD5 5 +Regulation of mitochondrion organization 0.3406824182619563 0.4799460889510979 0.6312657277914857 1.0 1.0 37 Q9H300,O14737,P21796,Q09472,P02786,Q9Y6C9,Q96A26,P42858 8 +Amyloid precursor protein metabolic process 0.3720861241850803 0.4794217474831596 0.6316386252367971 1.0 1.0 16 Q9NQC3,O95197,Q15392 3 +Regulation of cellular component size 0.3145384961332904 0.4782146109063214 0.6324974642949255 1.0 1.0 76 P52907,Q9P2J5,Q9Y5X1,Q14019,Q13045,P63000,O15145,P51790,P35080,P47755,O14786,P50552,Q96CW1,Q9NUQ9,P46821,P07737,Q9NQC3,P07196,Q9UQB8,P43034,Q14247,P42345,Q96ST3,Q6IBS0,P35241,O75083,Q4KMQ2,Q9UEY8,Q9Y281,Q7L576,P35611 31 +Positive regulation of cytokine production 0.3199716669091076 0.4779396131152627 0.6326931858178502 1.0 1.0 53 Q9BY67,Q9H2U1,P09601,P14373,O14802,Q99943,P62820,P05067,O15111,P09429,P26583,Q9NUD5 12 +Glycosylation 0.3347970252490045 0.4749636999599592 0.6348128468946499 1.0 1.0 44 O60502,P04062,Q9Y5P6,Q86YN1,O15118,O75503,Q6ZXV5 7 +Synaptic transmission dopaminergic 0.4598806366047683 0.4728707626575861 0.6363053851861704 1.0 1.0 5 Q99497,Q00535,O75955,P20337 4 +Oligosaccharide lipid intermediate biosynthetic process 0.4598000919550569 0.4725838993052938 0.6365100715874301 1.0 1.0 5 Q86YN1,Q2TAA5 2 +Regulation of organic acid transport 0.4231026997077615 0.4724943375863443 0.6365739824936179 1.0 1.0 8 Q15042 1 +Regulation of neuron differentiation 0.3509897691777233 0.4723572815342451 0.6366717904136359 1.0 1.0 21 Q15648,P26196,P46821,Q04917,Q96SZ6,P05067,O43379,Q8WUJ1,Q92974,Q9H8V3,Q99829 11 +Negative regulation of protein containing complex disassembly 0.3361778736981175 0.4714902144518867 0.6372907060404709 1.0 1.0 26 P47755,Q9P1Y5,P52907,Q7Z460,P46821,Q6IBS0,Q13045,P35241,P35611,P29372,Q92974 11 +Regulation of actin filament bundle assembly 0.3508176807841732 0.4713247213883975 0.6374088643613496 1.0 1.0 21 P63167,O14786,P42345,Q7Z460,P07737,P63000,P35241,Q96AC1 8 +Protein kinase b signaling 0.3456005745245707 0.4710773109889448 0.6375855270040749 1.0 1.0 22 Q86UE4,P42345,P07900,P63244,Q9NQC3,Q96AC1,Q13641 7 +Fatty acid transport 0.3703884819487853 0.4704739421534412 0.6380164470081566 1.0 1.0 16 P23786 1 +Polyamine metabolic process 0.6624242647112688 0.4686177277791884 0.6393429034019682 1.0 1.0 3 P49366 1 +Spermidine metabolic process 0.6624242647112688 0.4686177277791884 0.6393429034019682 1.0 1.0 3 P49366 1 +Regulation of immune response 0.3406633422544021 0.4674737348357685 0.6401609793718896 1.0 1.0 103 Q96J02,P02786,Q8WXF1,P09601,P07900,P61088,Q07666,P49770,Q9NR50,Q9Y3Z3,Q09472,P28070,Q9BY67,P19474,P43246,Q9NQC3,O43657,P26583,P15151,P46379,Q9NPR9,P09429,Q9Y4E8,Q9NUD5,Q9NZ08,Q15648,Q15233,P14373,Q9NQT5,Q92890 30 +Fatty acid beta oxidation 0.338862069446352 0.4635329684060185 0.642982389160383 1.0 1.0 35 Q9BWD1,P23786 2 +Negative regulation of peptidase activity 0.3386406966215399 0.4623631798734177 0.6438208990813301 1.0 1.0 33 Q96K76,P30086,P16435,P05067,Q15392 5 +Regulation of supramolecular fiber organization 0.3332849129559941 0.461914912373971 0.6441423396091128 1.0 1.0 96 P63167,P78559,P52907,Q9Y5X1,Q14019,P63000,Q13045,O15145,Q96AC1,P35080,P47755,Q9P1Y5,O14786,P50552,Q99471,P04350,Q7Z460,Q9NUQ9,P46821,P07737,Q16625,P05067,Q9UQB8,P29372,Q14247,P42345,Q9UHV9,Q6IBS0,P35241,O75083,Q92974,P23396,Q9UEY8,Q9Y281,P14373,P35611,O15212 37 +Cell junction maintenance 0.4035163378029643 0.4604458463026685 0.6451962335067309 1.0 1.0 9 P56545,Q15334,Q96AC1 3 +Multicellular organismal signaling 0.3381596275684633 0.4593029009783827 0.6460166648350025 1.0 1.0 23 Q12955,P04062,O75844 3 +Negative regulation of hormone metabolic process 0.6628022524014655 0.4566880840456352 0.6478952568632492 1.0 1.0 2 O60678 1 +Response to glycoside 0.6628022524014655 0.4566880840456352 0.6478952568632492 1.0 1.0 2 O96017 1 +Positive regulation of blood circulation 0.6628022524014654 0.4566880840456343 0.6478952568632499 1.0 1.0 2 P16615 1 +Negative regulation of protein serine threonine kinase activity 0.3703153006636225 0.4561745149526426 0.6482644900719992 1.0 1.0 15 Q53EL6 1 +Ear development 0.347950729398075 0.4541872842404652 0.6496940344244706 1.0 1.0 21 P43034,P42892,Q9Y6M7,P54802 4 +Negative regulation of immune system process 0.3375363874509541 0.4540033450781074 0.6498264191714012 1.0 1.0 35 Q96J02,Q9Y3Z3,P28070,P09601,P14373,P19474,Q13315,Q00534,P09429,Q9Y4E8 10 +Megakaryocyte differentiation 0.3858886714629821 0.4537194369011359 0.6500307753467311 1.0 1.0 11 Q15648,Q99873 2 +Female meiotic nuclear division 0.401861937017431 0.4534787561660102 0.6502040371700433 1.0 1.0 9 Q13315,P30153,Q15003 3 +Synaptonemal complex organization 0.4346913287875371 0.4528719398946571 0.6506409574484882 1.0 1.0 7 P46379 1 +Proton transmembrane transport 0.3330669648287545 0.4527829481258867 0.650705043464411 1.0 1.0 43 Q96ES6,P21281,P00846,O75964,Q9UDW1 5 +Cardiocyte differentiation 0.3603990922835517 0.452138155369496 0.6511694578914788 1.0 1.0 18 Q53EL6 1 +Cellular potassium ion homeostasis 0.5094858030197393 0.4501234722456614 0.6526214129020365 1.0 1.0 4 P05026,P05023 2 +Potassium ion homeostasis 0.5094858030197393 0.4501234722456614 0.6526214129020365 1.0 1.0 4 P05026,P05023 2 +Cellular sodium ion homeostasis 0.5094858030197393 0.4501234722456614 0.6526214129020365 1.0 1.0 4 P05026,P05023 2 +Glutamine metabolic process 0.3773565182392834 0.4487676555258723 0.6535992736014506 1.0 1.0 13 O43175,Q9NRF8,P17812,Q06203,Q06210,P08243 6 +L alpha amino acid transmembrane transport 0.3846911117835932 0.4482732575504742 0.6539559982352736 1.0 1.0 11 Q9H936,Q9UPY5,O75915,O60831,Q9Y619,O75746 6 +Protein k63 linked deubiquitination 0.4005491106758607 0.4479714910378785 0.6541737717053435 1.0 1.0 9 O00487,O95630,Q93009,Q15018 4 +Golgi localization 0.5087835598276329 0.4478886584073357 0.654233554030041 1.0 1.0 4 Q9Y678,P63104,P48444 3 +Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.6546071167531404 0.4467416213681481 0.655061626434164 1.0 1.0 3 P63241 1 +Erythrocyte homeostasis 0.3363441878853951 0.4454613887105603 0.6559863570050743 1.0 1.0 35 O43251,Q15648,P09601 3 +Calcium ion export 0.5077891945641263 0.4447316780070446 0.6565136737102377 1.0 1.0 4 O95202,P23634,P20020 3 +Membrane disassembly 0.4517594274533767 0.4442570704176228 0.6568567350795849 1.0 1.0 5 P43034,P53350 2 +Positive regulation of membrane depolarization 0.6536558715056141 0.4441104517767981 0.6569627302971224 1.0 1.0 3 Q12955 1 +Nerve development 0.4157921708011117 0.4432773922020668 0.657565106175904 1.0 1.0 8 Q9UPY3,P83731,P42892 3 +Mitotic g2 m transition checkpoint 0.3759187207338336 0.4418760362659052 0.6585789124150947 1.0 1.0 13 Q6NUQ1,O14757,Q68E01,P06493,Q9NWV8,Q13315,Q9Y619 7 +Regulation of histone ubiquitination 0.3830062156655797 0.4406399595136378 0.659473669277393 1.0 1.0 11 O75150,Q96FW1 2 +Semaphorin plexin signaling pathway 0.4312057175050874 0.439747986022569 0.6601196435436045 1.0 1.0 7 P42892,O14786,P52565 3 +Negative regulation of endocytosis 0.3791874111017932 0.4393475042425627 0.6604097580817694 1.0 1.0 12 O00560,P05067 2 +Odontogenesis of dentin containing tooth 0.4310767298850541 0.4392646712511609 0.6604697698185842 1.0 1.0 7 P35613,Q12948 2 +Cellular response to uv 0.3400567047753624 0.4370727209749306 0.6620586099407215 1.0 1.0 22 Q09472,Q96KB5,P28340,Q96K76,Q9H2U1,P61254,O14757 7 +Terpenoid metabolic process 0.360656829807056 0.4351587656638308 0.6634471904337425 1.0 1.0 17 Q9HB40,Q6NUM9,O60678,P51648 4 +Regulation of leukocyte mediated immunity 0.3316040401176466 0.4350507655882162 0.6635255793462835 1.0 1.0 27 Q9BY67,P02786,Q9NQT5,P09601,P09429,P15151 6 +Negative regulation of axonogenesis 0.4485958379400933 0.4332857261068387 0.6648072066075148 1.0 1.0 5 Q9NQC3 1 +Dna replication checkpoint signaling 0.5040285732865835 0.4328724973688965 0.6651074012785334 1.0 1.0 4 Q9UNS1 1 +Suppression of viral release by host 0.4479872572012717 0.4311867864414783 0.6663325608960431 1.0 1.0 5 P19474 1 +Positive regulation of potassium ion import across plasma membrane 0.648192842871079 0.4291325985745879 0.6678267301878928 1.0 1.0 3 Q9Y3S1 1 +Regulation of potassium ion import 0.648192842871079 0.4291325985745879 0.6678267301878928 1.0 1.0 3 Q9Y3S1 1 +Activated t cell proliferation 0.447177504203013 0.4283999070173133 0.6683599923676327 1.0 1.0 5 Q9BY67 1 +Synaptic vesicle maturation 0.6479067646228186 0.4283545822965041 0.6683929857732687 1.0 1.0 3 Q15334 1 +Protein poly adp ribosylation 0.6477799867461974 0.4280100012275449 0.6686438389945053 1.0 1.0 3 Q9UGN5,Q7Z2W4 2 +Meiosis i cell cycle process 0.3521549494321145 0.4275798666400525 0.6689570266478015 1.0 1.0 19 P46379,Q13315,Q9BTX1,P52701,Q92791 5 +Rna interference 0.4278514490459804 0.4272351955517767 0.6692080285805919 1.0 1.0 7 Q9UPY3,Q15631 2 +Trna pseudouridine synthesis 0.6518714806227311 0.4246315666864783 0.6711052776577855 1.0 1.0 2 Q96PZ0 1 +Histone phosphorylation 0.3472282861724213 0.4231151436292932 0.6722112540613137 1.0 1.0 20 O14757,Q13315,Q8IV63,P54646,O75844 5 +Bone remodeling 0.4106401292364846 0.4230265094904483 0.6722759197846442 1.0 1.0 8 Q92791,O14773 2 +Regulation of chromatin organization 0.3581256739151508 0.42178794116353 0.6731798083454379 1.0 1.0 17 Q86UE8 1 +Epithelial to mesenchymal transition 0.3372823057605603 0.4202454430512901 0.6743061605699894 1.0 1.0 22 P42345,Q7Z460,Q99729,Q9NQC3,Q96AC1,O00560,Q53EL6,Q12948 8 +Cellular response to hormone stimulus 0.3509239244600245 0.4201376827980799 0.67438487583129 1.0 1.0 119 Q9BSK2,O00443,Q15648,P43490,P11802,P42785,O43251,O15118,P32780,P16435,Q9NUQ7,Q8TBX8,P48507,Q9UQB8,Q16739,Q9H7B4,O15173,O43865 18 +Positive regulation of dna damage response signal transduction by p53 class mediator 0.4999363503802839 0.4201148708708949 0.6744015396383298 1.0 1.0 4 Q13315,P61254 2 +Negative regulation of transcription from rna polymerase ii promoter in response to stress 0.6502153030804987 0.4198719755973478 0.6745789812816689 1.0 1.0 2 Q8IXJ6 1 +Dna modification 0.3311235670175665 0.4176419396608389 0.6762089282541472 1.0 1.0 30 Q9UGN5,Q9NQT4,Q8NB78,P49711,P26358,Q96TA1,Q9NQT5,O75844 8 +Innervation 0.6437558831968588 0.4171378345449931 0.6765775924860664 1.0 1.0 3 P42892 1 +Dendritic spine morphogenesis 0.3624336915280753 0.4163492028797511 0.6771544933392244 1.0 1.0 15 P43034,Q15334,Q9UQB8 3 +Neurotransmitter transport 0.3253527917589396 0.4147939459857087 0.678292751806884 1.0 1.0 24 Q99808,P50897,Q15042,Q06787,P56545,P16615,P35080 7 +Peroxisome proliferator activated receptor signaling pathway 0.4981153099034043 0.4144881517657468 0.6785166423837508 1.0 1.0 4 Q15648 1 +Nucleotide excision repair 0.3408860275025652 0.4125084151757343 0.6799668139881097 1.0 1.0 21 Q96T60,P18074,P28340,P32780,P09884,Q07864,P19447,Q93009,P35244,P15927 10 +Positive regulation of mitochondrial depolarization 0.6475654190129269 0.4123113464941645 0.6801112331613757 1.0 1.0 2 P63244 1 +L amino acid transport 0.3729855965297316 0.4107896380886076 0.6812267918194699 1.0 1.0 12 Q9H936,Q9UPY5,O75915,O60831,Q9Y619 5 +Somatic diversification of immunoglobulins 0.3559783332533556 0.4105178305907365 0.6814261263532067 1.0 1.0 17 Q9NQT5,Q9Y3Z3,Q9UQ84,P52701 4 +T cell mediated immunity 0.3789584221958186 0.4087707191323337 0.6827079299607954 1.0 1.0 10 P09429,Q9BY67 2 +Regulation of hematopoietic progenitor cell differentiation 0.3788348520707255 0.4082387580879137 0.6830983959377803 1.0 1.0 10 Q96J02,Q9H2U1,Q00534,Q12948 4 +Process utilizing autophagic mechanism 0.3747034944303186 0.4068681349625557 0.6841048407655368 1.0 1.0 148 O00443,P21796,A5D8V6,Q86UE4,Q9Y296,P50851,P09601,Q15042,Q13315,Q9Y487,P10619,Q96AX1,Q8WUX9,Q9UNH7,P42858,Q9Y4P8,Q7Z3C6,Q09472,O15118,P19474,Q9NT62,O15269,O75844,P42345,Q93050,Q9UII2,Q9UBQ0,P62820,P16615,P09429,P54646,Q9H300,P07602,Q86UE8,Q05639,P04062,Q9NZJ7,Q96GC9,P14373,P21281,Q9HAD4,Q8TBX8,Q9BWH2,Q9Y263 44 +Copi coated vesicle budding 0.6394963552021239 0.4057695294772739 0.6849119491967095 1.0 1.0 3 P49755,Q92538 2 +Golgi vesicle budding 0.6394963552021239 0.4057695294772739 0.6849119491967095 1.0 1.0 3 P49755,Q92538 2 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.3300644928771178 0.4044366767520426 0.6858916342578016 1.0 1.0 32 P46379,P04062 2 +Macrophage activation 0.421568565969365 0.40411771415324 0.6861261593228105 1.0 1.0 7 P05067 1 +Leukocyte migration 0.326547521203669 0.4022457253256447 0.6875031937009213 1.0 1.0 43 P35613,P04062,P09601,P05067,Q4KMQ2 5 +Cartilage development 0.3670995976934517 0.4001920484325247 0.6890150708068044 1.0 1.0 13 O75844 1 +Growth plate cartilage development 0.6370035736836636 0.3991844581478949 0.6897572941238419 1.0 1.0 3 O75844 1 +Bone growth 0.6370035736836636 0.3991844581478949 0.6897572941238419 1.0 1.0 3 O75844 1 +Autophagosome maturation 0.3564490950382153 0.3984408763460501 0.6903052318481449 1.0 1.0 16 Q8WUX9,Q96GC9,Q96AX1 3 +Cardiac ventricle morphogenesis 0.4924941598173055 0.3973206270326501 0.6911310384416689 1.0 1.0 4 Q15648 1 +Ventricular cardiac muscle tissue morphogenesis 0.4924941598173055 0.3973206270326501 0.6911310384416689 1.0 1.0 4 Q15648 1 +Cardiac muscle tissue morphogenesis 0.4924941598173055 0.3973206270326501 0.6911310384416689 1.0 1.0 4 Q15648 1 +Muscle organ morphogenesis 0.4924941598173055 0.3973206270326501 0.6911310384416689 1.0 1.0 4 Q15648 1 +Cellular response to acid chemical 0.3614872431399383 0.3916152691253225 0.6953425041575705 1.0 1.0 14 P26358,P48507,P42345,Q9UQB8 4 +Positive regulation of stress fiber assembly 0.3748785561919175 0.3913140363490814 0.6955651249108699 1.0 1.0 10 Q96AC1,P63000,O14786,P42345 4 +Response to amine 0.4902220749088391 0.3904693999954335 0.6961894783635099 1.0 1.0 4 P00492,P23378,P06493 3 +Regulation of protein serine threonine kinase activity 0.315812344747802 0.3904431368368272 0.6962088953396508 1.0 1.0 50 Q53EL6,P04062,Q9Y4G8,P42858 4 +Alpha beta t cell activation 0.3684962160909001 0.3904369412502652 0.6962134759127863 1.0 1.0 12 Q96J02,P09429,P42345 3 +Positive regulation of leukocyte proliferation 0.3683182054826844 0.3896356967187904 0.6968059520768848 1.0 1.0 12 P49366,P14174,P02786,P27361,P09429,P23396 6 +Negative regulation of response to biotic stimulus 0.3546746813244505 0.3894705745369712 0.6969280738295061 1.0 1.0 16 Q9Y3Z3,O43657 2 +Phospholipid metabolic process 0.3013604838603183 0.3880807195484979 0.6979562995794404 1.0 1.0 72 O00443,P37287,Q9Y217,Q8NHP8,Q96N66,P35790,Q86YN1,Q8NCC3,Q99943,Q13315,Q9NPH0,Q8WTV0,Q8TBX8,P43034,Q8WUK0 15 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.6325381047050989 0.3875159222186894 0.6983742997437936 1.0 1.0 3 O75832,P14174 2 +Intracellular receptor signaling pathway 0.3053311906557757 0.3867427881394082 0.6989466359226744 1.0 1.0 55 Q96J02,Q15648,Q15120,Q09472,P42785,O43251,P56545,Q86X55,Q15185,Q9NUQ7,O43657,Q9Y4E8,Q9NUD5 13 +Synapse assembly 0.3445570522877735 0.3857742551596596 0.6996638635958417 1.0 1.0 19 Q13641,P05067 2 +Amino acid import 0.416395438424184 0.3854108043486501 0.6999330789979534 1.0 1.0 7 O75915,Q96NB2 2 +Regulation of receptor internalization 0.3705492874536416 0.3853271986262312 0.6999950127922878 1.0 1.0 11 Q15334,O00560 2 +Tube morphogenesis 0.3285122099988605 0.385237810709795 0.7000612321513402 1.0 1.0 99 P35613,Q9NZ08,O00443,Q15648,P63167,P50552,Q96AY3,P42785,P09601,Q13685,Q4VCS5,P15291,O95470,Q96TA1,Q9Y4G8,P25440,Q9UNS1,Q12948 18 +Trna catabolic process 0.3733412439956898 0.3847945611246645 0.7003896290447162 1.0 1.0 10 Q15024,Q9UPY3,Q08J23 3 +Apoptotic mitochondrial changes 0.32556827849276 0.3847584369057676 0.7004163953998714 1.0 1.0 29 O14737,P45880,Q9NT62,Q96A26,O75223,P48507,Q9H300 7 +Response to uv 0.3274493847810202 0.3845481759934981 0.7005721962767435 1.0 1.0 33 Q09472,Q96KB5,P28340,Q96K76,Q9H2U1,P61254,O14757,P12004,P19447,P52701,P55210 11 +Carnitine metabolic process 0.433270178739099 0.3816271626181057 0.7027379335930255 1.0 1.0 5 P23786 1 +Molting cycle 0.3724851685517981 0.3811782340712073 0.7030709988267263 1.0 1.0 10 O75844 1 +Regulation of protein localization to endosome 0.6298873426109969 0.380668018434702 0.703449602854402 1.0 1.0 3 P35241,P26038 2 +Positive regulation of protein localization to early endosome 0.6298873426109969 0.380668018434702 0.703449602854402 1.0 1.0 3 P35241,P26038 2 +Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.3660777939299903 0.3795899789923287 0.7042498006306062 1.0 1.0 12 Q8WUX9,A5D8V6 2 +Autophagosome organization 0.3229823908235701 0.3786028889216681 0.704982776551847 1.0 1.0 27 P04062,P50851,Q96GC9,Q15042,P62820,Q9NT62,Q8TBX8,P16615,Q9Y4P8,Q7Z3C6 10 +Lipid oxidation 0.3259844456987933 0.3778992388460331 0.7055054479040856 1.0 1.0 39 Q9BWD1,P23786,P49748,P16435 4 +Type i interferon production 0.3207388709504248 0.3776873356054853 0.7056628768972866 1.0 1.0 25 Q96J02,Q9H2U1,O14802,P19474,O15111,Q92890,P26583,Q9NUD5 8 +Neutrophil homeostasis 0.6285903200072063 0.3773389642649699 0.7059217193368519 1.0 1.0 3 P09429 1 +Viral budding 0.3681810965561534 0.3750495285190005 0.7076236321324716 1.0 1.0 11 Q8WUX9,A5D8V6 2 +Dorsal root ganglion development 0.6276529287290001 0.374941887918687 0.7077036856723447 1.0 1.0 3 Q13509 1 +Ganglion development 0.6276529287290001 0.374941887918687 0.7077036856723447 1.0 1.0 3 Q13509 1 +Long term synaptic potentiation 0.3822563413347078 0.3733546320867194 0.70888452057176 1.0 1.0 9 P05067,Q14168 2 +Inner mitochondrial membrane organization 0.3455244657993266 0.372252888748479 0.7097045714123824 1.0 1.0 18 Q13505,Q9Y512 2 +Positive regulation of interleukin 6 production 0.3972280996416089 0.3717395538659769 0.7100867723435571 1.0 1.0 8 P05067 1 +Response to bmp 0.3606324697463171 0.3703120201867889 0.711150018629694 1.0 1.0 13 Q53EL6 1 +Positive regulation of chromatin binding 0.6323285856243883 0.3701855408320053 0.7112442492946194 1.0 1.0 2 P56545 1 +Regulation of glycolytic process 0.3966835605218491 0.3697035644171134 0.7116033756653255 1.0 1.0 8 P05067 1 +Positive regulation of protein containing complex assembly 0.3115168791587854 0.3691546021707786 0.7120124919310025 1.0 1.0 51 P50552,P42345,P02786,Q7Z460,Q9Y5X1,P07737,Q16625,Q13315,Q9UQB8,Q96AC1 10 +Positive regulation of sodium ion transport 0.3635650128522721 0.3684096606570689 0.7125677950957301 1.0 1.0 12 Q12955,O43865 2 +Protein o linked glycosylation 0.3502187439395919 0.3671606272001835 0.7134992063669059 1.0 1.0 16 O60502 1 +Cytoplasmic sequestering of transcription factor 0.4819356977129501 0.3659262845222715 0.7144200823777 1.0 1.0 4 Q9UN86,O75832,Q9UNN5 3 +Negative regulation of establishment of protein localization 0.3280286576184054 0.3651274733343431 0.7150162538208986 1.0 1.0 22 Q16850,Q9GZP9 2 +Positive regulation of non motile cilium assembly 0.4816042426251141 0.3649593591859177 0.7151417434981295 1.0 1.0 4 P27695,Q9UHD8,Q15555 3 +Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway 0.6236991839662681 0.3649145317187114 0.7151752064937191 1.0 1.0 3 Q9NVX2 1 +Positive regulation of tau protein kinase activity 0.6303411725737094 0.364865264345614 0.7152119844402722 1.0 1.0 2 P07900 1 +Regulation of tau protein kinase activity 0.6303411725737094 0.364865264345614 0.7152119844402722 1.0 1.0 2 P07900 1 +Positive regulation of cell size 0.6303411725737093 0.3648652643456131 0.7152119844402729 1.0 1.0 2 O60341 1 +Neuron projection organization 0.3229034143514657 0.3646712257747514 0.715356840081371 1.0 1.0 23 P78559,Q15334,P05067,Q9UQB8,P43034,O60678 6 +Nucleotide phosphorylation 0.3247419643134083 0.3646093821881201 0.7154030103369788 1.0 1.0 34 Q96T60,Q09472,P05067,Q9BRR6,O75414 5 +Dicarboxylic acid catabolic process 0.4104081295305748 0.3641472578102732 0.7157480491563315 1.0 1.0 7 Q9NRN7 1 +Sphingoid metabolic process 0.4278116233397184 0.3638616429894502 0.7159613285785094 1.0 1.0 5 Q13510,P04062 2 +Negative regulation of interleukin 2 production 0.6296787015568164 0.3631010114200175 0.716529429106757 1.0 1.0 2 P14373 1 +Sphingolipid mediated signaling pathway 0.6296787015568164 0.3631010114200175 0.716529429106757 1.0 1.0 2 P63000 1 +Vascular endothelial growth factor signaling pathway 0.4807478696409482 0.3624665042799551 0.7170034498796733 1.0 1.0 4 Q12948 1 +Intraciliary transport involved in cilium assembly 0.6293474660483698 0.3622206117855285 0.7171871779239511 1.0 1.0 2 Q15154 1 +Hypothalamus cell differentiation 0.6290162305399234 0.3613413654240549 0.7178442745048899 1.0 1.0 2 O14786 1 +Viral translation 0.3509829219285634 0.360062642598277 0.7188002886285703 1.0 1.0 15 O75821,P41214,Q9Y262 3 +Mitochondrial atp synthesis coupled proton transport 0.3614597377044953 0.3591148128609623 0.719509200679606 1.0 1.0 12 P00846 1 +Interleukin 8 production 0.3936276136740801 0.358348059838569 0.7200828562984571 1.0 1.0 8 O95999,Q7Z434,Q99497,P0DMV9,P62820,P09429,Q6GQQ9 7 +Negative regulation of cell growth 0.3216454580454114 0.3570717606982794 0.7210380845039901 1.0 1.0 23 P50897,Q9NQC3 2 +Negative regulation by host of viral transcription 0.4782896917467572 0.3553541797492844 0.7223242709232229 1.0 1.0 4 Q13148,Q13547,Q9H1E3 3 +Positive regulation of exosomal secretion 0.4077985205882147 0.3550144639230376 0.7225787554803509 1.0 1.0 7 O00560 1 +Regulation of exosomal secretion 0.4077985205882147 0.3550144639230376 0.7225787554803509 1.0 1.0 7 O00560 1 +Fucose metabolic process 0.6192439330843201 0.3537783913394776 0.7235049687663595 1.0 1.0 3 P04066 1 +Regulation of smoothened signaling pathway 0.3922959537905567 0.3534377175887184 0.7237603135160628 1.0 1.0 8 P16435,Q8NCM8,Q8WWQ0 3 +Cerebral cortex cell migration 0.3631211627702954 0.3533632449649866 0.7238161369803666 1.0 1.0 11 P50542,Q9NQC3,Q96N66 3 +Cellular response to oxygen levels 0.3223816871215026 0.3525701591687493 0.7244107122307897 1.0 1.0 32 Q15120,Q99808,P09601,Q9Y487,Q96A26,O94966 6 +Regulation of ubiquitin protein ligase activity 0.3628550182221124 0.3522331604259167 0.7246634100484266 1.0 1.0 11 P62841,P53350,P62913,Q13257,P62829,P46777 6 +Threonine metabolic process 0.618099391865752 0.3509458312255261 0.7256289871582968 1.0 1.0 3 P52758 1 +Urogenital system development 0.3197573250182832 0.3506721886935366 0.7258342923866778 1.0 1.0 43 P46379,P07602,Q8NCM8,Q9BW83,Q9NZJ7,P49454,O95470,P52758,O75844,Q12948 10 +G quadruplex dna unwinding 0.617712850917618 0.3499918361232422 0.7263448244894086 1.0 1.0 3 P22626 1 +Regulation of microtubule depolymerization 0.362279131362102 0.3497915612945768 0.7264951325780691 1.0 1.0 11 Q9P1Y5,P78559,Q7Z460,P46821,P29372 5 +Positive regulation of g1 s transition of mitotic cell cycle 0.3557280423206038 0.3480710864825313 0.7277867978713704 1.0 1.0 13 Q96DY7 1 +Translesion synthesis 0.4224155848697662 0.3466475201524246 0.7288561409914049 1.0 1.0 5 P12004,P28340 2 +Inner cell mass cell differentiation 0.6233852268963329 0.3465721026211798 0.7289128072657105 1.0 1.0 2 Q9NVX2 1 +Adherens junction maintenance 0.6148576275951139 0.3429864816623038 0.731608630067454 1.0 1.0 3 Q96AC1 1 +Cell cell junction maintenance 0.6148576275951139 0.3429864816623038 0.731608630067454 1.0 1.0 3 Q96AC1 1 +Positive regulation of plasma membrane bounded cell projection assembly 0.319252428606385 0.3427093506763937 0.7318171274662704 1.0 1.0 23 O14786,P42345,Q7L576,P07737,Q06787,Q16625,P63000,Q6IBS0,Q9UHD8,P42858 10 +Negative regulation of lymphocyte differentiation 0.4738521089210974 0.3426797636798532 0.7318393881892971 1.0 1.0 4 P09429 1 +Regulation of rig i signaling pathway 0.4209075729500827 0.3419003206235286 0.7324259083386895 1.0 1.0 5 Q9Y4E8 1 +Scf dependent proteasomal ubiquitin dependent protein catabolic process 0.4038810282910702 0.3414635613391656 0.7327546320361511 1.0 1.0 7 Q13616,Q13309,Q15058,Q13617 4 +Atp synthesis coupled proton transport 0.3540555833009697 0.3405734005211477 0.7334247568315406 1.0 1.0 13 P00846 1 +Regulation of t cell mediated cytotoxicity 0.4730331387991915 0.340364199889082 0.7335822753292778 1.0 1.0 4 P15151 1 +Positive regulation of t cell mediated cytotoxicity 0.4730331387991915 0.340364199889082 0.7335822753292778 1.0 1.0 4 P15151 1 +Pyrimidine nucleoside triphosphate biosynthetic process 0.3623250637585892 0.3390646649440921 0.7345610166525338 1.0 1.0 10 P17812,O75414,Q9NRF8 3 +Positive regulation of smoothened signaling pathway 0.4725590737753978 0.3390272105263254 0.7345892317509857 1.0 1.0 4 P16435 1 +Glial cell migration 0.3565919059972668 0.3378843270655791 0.7354503588788548 1.0 1.0 12 Q96G23,Q9NQC3,Q96N66 3 +Cytokine mediated signaling pathway 0.319996228733588 0.3378828773911747 0.7354514513748318 1.0 1.0 40 Q9Y3Z3,Q15648,Q99943,P43034,Q16739,P63241,Q12948 7 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.472120088807803 0.3377913774152365 0.7355204081867244 1.0 1.0 4 Q13257,P14635 2 +Alpha beta t cell differentiation 0.3879240301998594 0.3374826465162235 0.7357530917163562 1.0 1.0 8 P09429,P35268,P42345 3 +Viral translational termination reinitiation 0.4027391511417171 0.3358907353030588 0.7369532637466027 1.0 1.0 6 Q9Y262 1 +Regulation of synapse maturation 0.6190791652865285 0.3355077333988089 0.7372421120403225 1.0 1.0 2 P63104 1 +Activation of innate immune response 0.3272935956018822 0.334809257913235 0.7377689763839708 1.0 1.0 21 P09429,Q15233,Q09472,Q9NUD5 4 +Positive regulation of actin nucleation 0.6114258097397269 0.3346638598741227 0.7378786665197745 1.0 1.0 3 P14373 1 +Negative regulation of leukocyte chemotaxis 0.6113269300103115 0.3344256526170549 0.7380583846483284 1.0 1.0 3 P14174 1 +Regulation of nitric oxide metabolic process 0.3870100626880087 0.3341799034021909 0.7382438078956941 1.0 1.0 8 P06280,P07900,Q92945 3 +Negative regulation of actin filament depolymerization 0.3450537926735845 0.3317316162852352 0.7400919249280156 1.0 1.0 15 P47755,P52907,Q6IBS0,Q13045,P35241,P35611 6 +Cell surface receptor signaling pathway involved in cell cell signaling 0.2892455202233384 0.3317235528293528 0.7400980142045945 1.0 1.0 66 Q99808,Q96K76,Q15042,Q15334,P05067,Q9UQB8,Q14168,Q8TAA9,Q13641,Q6DKJ4 10 +Primitive hemopoiesis 0.617422987744296 0.331305995457308 0.7404133630813081 1.0 1.0 2 Q13769 1 +Cellular response to light stimulus 0.3118633778287883 0.3300828042462717 0.7413373959730687 1.0 1.0 24 Q09472,Q96KB5,P28340,Q96K76,Q9H2U1,P61254,O14757 7 +Pyrimidine ribonucleotide metabolic process 0.3515707862275481 0.3295180760353236 0.7417641334615899 1.0 1.0 13 P17812,O75414,Q9NRF8,P30085 4 +Mitotic g2 dna damage checkpoint signaling 0.3708823952405999 0.3291701774048013 0.7420270629816483 1.0 1.0 9 Q6NUQ1,O14757,Q9NWV8,P06493,Q13315 5 +Pro b cell differentiation 0.6154355746936171 0.3263037277767609 0.7441945680918169 1.0 1.0 2 P78527 1 +Lymphoid progenitor cell differentiation 0.6154355746936171 0.3263037277767609 0.7441945680918169 1.0 1.0 2 P78527 1 +Response to gamma radiation 0.3435894398512149 0.3248265826884677 0.7453123244912532 1.0 1.0 15 O75844 1 +Cellular homeostasis 0.3474326600142999 0.3245462486235524 0.7455245140438387 1.0 1.0 126 P09601,O75503,Q15334,Q96AX1,P42858,P05067,Q9HD20,Q9NQC3,P78417,O75880,P50897,Q93050,Q4KMQ2,Q9BPX6,P10253,P00390,Q9Y6M7,Q9BWH2,P48507 19 +Regulation of cellular respiration 0.3433253931273347 0.3235854866587526 0.7462518772529256 1.0 1.0 15 P14406,O14548 2 +Regulation of dna primase activity 0.6063618290258435 0.3225801285204736 0.7470132449922675 1.0 1.0 3 P49643,Q9BRX5 2 +Negative regulation of cell cycle g2 m phase transition 0.3410651903286784 0.322366161562014 0.7471753161986756 1.0 1.0 16 Q96K76,O14757,Q68E01,P06493,Q13315,Q9Y619 6 +Vascular endothelial growth factor receptor signaling pathway 0.3836684837267747 0.3222032352019175 0.7472987337402033 1.0 1.0 8 Q96TA1,Q12948 2 +Leukocyte proliferation 0.3172330816411513 0.3219328449369923 0.7475035700301418 1.0 1.0 31 Q96J02,P49366,P04062,Q9BY67,P02786,Q13315,Q92542,P09429 8 +Muscle structure development 0.3069934148559813 0.3212785103649708 0.7479993401365199 1.0 1.0 84 Q15648,Q09472,Q8IV08,Q16527,P16989,Q9UGN5,P49454,O94966,Q96TA1,Q9H4M9,Q13045,Q53EL6,P60660,Q9H7B4,Q7Z4V5,O75844,Q12948 17 +Negative regulation of gtpase activity 0.3980658975453148 0.3205049006052083 0.7485856160036091 1.0 1.0 6 Q9P258 1 +Glycerol ether metabolic process 0.3831677624972858 0.3204220862395556 0.748648385031562 1.0 1.0 8 P43034,Q6PIU2 2 +Regulation of hematopoietic stem cell differentiation 0.397669678433 0.3203821992091054 0.7486786179425988 1.0 1.0 7 Q96J02,Q00534,Q12948 3 +Myeloid cell development 0.3351549071103412 0.3187589662495638 0.7499092964935572 1.0 1.0 18 Q15648,Q09472,P05067 3 +Positive regulation of cell growth 0.3179005634086227 0.3181366282138754 0.7503813005331108 1.0 1.0 38 Q9BSK2,O14786,Q9UGN5,Q96K76,P46821,Q9GZP9,Q6IBS0,Q7Z4V5,P43034,O00560,O43598,Q9Y263 12 +Muscle organ development 0.3170824349851029 0.3176020540467245 0.7507868158551327 1.0 1.0 32 Q15648,Q09472,P16989,P49454,Q96TA1,P60660,Q12948 7 +Regulation of cell cycle g2 m phase transition 0.3165348120443827 0.3140288520077224 0.7534991256419248 1.0 1.0 32 Q6NUQ1,P11802,Q96K76,P49454,Q96ST3,O14757,Q68E01,Q9NWV8,P06493,Q13315,P05067,Q15058,P14635,Q9BTC8,Q9Y619,Q9P258 16 +Purine deoxyribonucleoside monophosphate metabolic process 0.6094733355415802 0.3115603991297462 0.7553746340405771 1.0 1.0 2 P00491 1 +Damp metabolic process 0.6094733355415802 0.3115603991297462 0.7553746340405771 1.0 1.0 2 P00491 1 +Regulation of binding 0.3118939978269152 0.3101628207564861 0.7564371419958316 1.0 1.0 90 Q7L2J0,Q9BUN8,P09601,P56545,O75503,Q9Y4G8,P62826,O14786,Q09472,P19474,P05067,P26583,O75844,Q12948,Q86X55,P09429,P10586,Q96TA1,P35611 19 +Positive regulation of signal transduction by p53 class mediator 0.3549871471507492 0.3096299334115488 0.7568423906322739 1.0 1.0 10 P61254,Q13315,O43324,P62841,P63241 5 +5s class rrna transcription by rna polymerase iii 0.3945412682943113 0.3090948093234036 0.7572494075529075 1.0 1.0 6 Q969F1 1 +Glycoprotein metabolic process 0.2963346364317946 0.3069054460187757 0.7589153436740133 1.0 1.0 55 O60502,Q9Y5P6,Q86YN1,O15118,Q6ZXV5,Q8NCH0,Q2TAA5,Q7LGA3 8 +Keratinocyte differentiation 0.3291519755772675 0.3041511848234429 0.761012712927565 1.0 1.0 19 Q16739,Q15648,Q12948 3 +Nucleus localization 0.3457139508060566 0.3038717811573421 0.7612255771952308 1.0 1.0 13 P43034,O94901,P42345,Q15154 4 +Meiotic chromosome segregation 0.3252448095917974 0.3020090380169825 0.7626451731299111 1.0 1.0 20 P46379,Q15003,Q9BTX1,Q92791 4 +Positive regulation of type i interferon production 0.325049006691089 0.3009733649383259 0.7634348050763513 1.0 1.0 20 Q9H2U1,O14802,O15111,P26583,Q9NUD5 5 +Lysine metabolic process 0.4585870940719093 0.3007673033992986 0.763591942702978 1.0 1.0 4 Q9NRN7 1 +Replication fork processing 0.3631796135562344 0.3003244604182572 0.7639296771709316 1.0 1.0 9 Q9Y3Z3,Q8NFC6 2 +Inflammatory response to antigenic stimulus 0.3630377814618785 0.2998019275804746 0.7643282449248274 1.0 1.0 9 P09429,P28070 2 +Gland development 0.2858547383165523 0.298857558986864 0.7650487309470813 1.0 1.0 66 P07602,Q15648,Q9BY67,Q9NZJ7,Q13505,P09601,P00403,Q9NQC3,O75844,Q12948 10 +Toxin transport 0.3470058393888234 0.2972037131009128 0.7663109872412219 1.0 1.0 12 P78371 1 +Regulation of release of cytochrome c from mitochondria 0.3517943964224512 0.2970963608136746 0.7663929426582925 1.0 1.0 10 Q96A26,Q9H300 2 +Cellular response to corticosteroid stimulus 0.3467614956037251 0.2961872981628147 0.7670870484892749 1.0 1.0 12 Q9H7B4 1 +Positive regulation of arp2 3 complex mediated actin nucleation 0.6025173898642038 0.2948673536795936 0.7680952116864121 1.0 1.0 2 Q7L576 1 +Substrate dependent cell migration 0.3898278537837408 0.2945063535207481 0.7683710091778966 1.0 1.0 7 O00560 1 +Isoprenoid metabolic process 0.3199517407868414 0.2943992141677387 0.7684528673202353 1.0 1.0 21 Q9HB40,Q6NUM9,O60678,P51648 4 +Regulation of neurotransmitter transport 0.3432702078506892 0.2933482944457276 0.7692559427938228 1.0 1.0 13 Q15042,P35080,P16615,Q06787 4 +Negative regulation of nuclear division 0.3234655305310205 0.2926286200407269 0.7698060352707947 1.0 1.0 20 P49454,O14757,Q13315,Q96DY7,O75414,Q13257 6 +Regulation of lipid kinase activity 0.3891171366376861 0.2922033735409381 0.7701311324280866 1.0 1.0 7 Q8TBX8 1 +Regulation of cell shape 0.3101020323989671 0.291176024100244 0.7709166985032931 1.0 1.0 28 Q9UQB8 1 +Nucleoside phosphate biosynthetic process 0.3128390989081198 0.2906798383770416 0.7712961927383986 1.0 1.0 93 P43490,P50897,Q8TB61,Q9NZ01,Q9NRF8,P00846,O75964 7 +Negative regulation of amyloid precursor protein catabolic process 0.360503495680996 0.2905191305894203 0.771419117484567 1.0 1.0 9 Q9NQC3 1 +Dicarboxylic acid metabolic process 0.3102655295297374 0.2864072549443908 0.7745662187011133 1.0 1.0 44 P00374,P48507,Q9H2D1 3 +Endothelial cell chemotaxis 0.4025198938992091 0.2863712804493546 0.7745937688918023 1.0 1.0 5 Q9NWH9,O14786,Q9BR76,P51153 4 +Intracellular estrogen receptor signaling pathway 0.3219423386133415 0.2846540636979481 0.7759091870471462 1.0 1.0 20 Q15648,Q86X55,Q9NUQ7,Q13309,Q9NZN8,O43251 6 +Nucleoside bisphosphate metabolic process 0.3080936607515557 0.2845454605097046 0.7759924006557459 1.0 1.0 46 P50897,Q9NZ01 2 +Regulation of nuclease activity 0.3726977546946457 0.2840145339709298 0.7763992425910888 1.0 1.0 8 P09429,Q15554,P26583 3 +Regulation of intrinsic apoptotic signaling pathway 0.3067082259516659 0.282604286657031 0.7774801939584621 1.0 1.0 47 Q15233,P45880,P16989,Q96K76,P31689,P63241,Q8WUK0 7 +Regulation of cellular response to transforming growth factor beta stimulus 0.3344331500890711 0.2825304522886937 0.7775367997218594 1.0 1.0 15 Q9Y3F4,Q09472,Q92896,O00560,Q9UNH7 5 +Tumor necrosis factor superfamily cytokine production 0.3342080088998593 0.2815103075628406 0.7783190233306372 1.0 1.0 15 Q9UPY3,P14174,P14373,P05067,P09429,Q92974 6 +Negative regulation of intracellular signal transduction 0.3128611000450098 0.2815092253372873 0.7783198532758338 1.0 1.0 94 P63167,P45880,Q96K76,Q13315,Q8IV63,O95630,P16989,P30086,P43034,Q53EL6,O43657,P42345,Q96KB5,P31689,Q9H300,Q15233,P04062,Q9Y3S1,Q96S59,P78318 20 +Stem cell proliferation 0.3451980023607909 0.2798063794325959 0.7796260570501197 1.0 1.0 11 P04062 1 +Negative regulation of cell substrate adhesion 0.357343422920458 0.2790894166105003 0.7801762048950027 1.0 1.0 9 Q9P258 1 +Platelet derived growth factor receptor signaling pathway 0.3448048106403677 0.278254002076613 0.7808173832795113 1.0 1.0 11 O00443 1 +Positive regulation of epithelial cell differentiation 0.3845970881286897 0.2777256695409699 0.7812229540358964 1.0 1.0 7 Q15648 1 +Endoplasmic reticulum to golgi vesicle mediated transport 0.290322022833661 0.2735038719350625 0.7844659163952044 1.0 1.0 56 Q15436,P24390,Q9Y282,O14579,P49257,O95070 6 +Regulation of reactive oxygen species biosynthetic process 0.369473240730284 0.2731345279193601 0.7847498060011613 1.0 1.0 8 P00403 1 +Regulation of cell projection organization 0.3291830161056374 0.2724000425701702 0.7853144399705243 1.0 1.0 112 Q14108,Q15334,Q9Y4G8,P42858,Q9P258,Q9HCE1,O14786,Q09472,P46821,P07737,Q9NR77,Q16625,Q9NT62,Q9NQC3,Q9UQB8,P43034,Q96G23,P42345,Q9H2U1,Q6IBS0,Q86X55,P08670,P10586,Q66K14,Q9H4M9,Q9Y277 26 +Monoubiquitinated protein deubiquitination 0.382813159622243 0.2720932818588317 0.7855502950444722 1.0 1.0 7 Q96K76 1 +Lymphocyte activation involved in immune response 0.3157978888230438 0.2720768534253822 0.7855629267136308 1.0 1.0 21 Q9UQ84,P42345,Q9NQT5,P52701,P09429 5 +Phosphorylation of rna polymerase ii c terminal domain 0.3818702955689179 0.2691353029018284 0.7878255645564756 1.0 1.0 7 P32780 1 +Artery morphogenesis 0.3962520034930193 0.2684889537744308 0.7883229764555941 1.0 1.0 5 Q96AY3,Q12948 2 +Amyloid beta formation 0.3542875199445844 0.2681932498419824 0.7885505705821809 1.0 1.0 9 Q9NQC3 1 +Smoothened signaling pathway 0.3286794788831796 0.2642103284783451 0.7916178527984443 1.0 1.0 16 Q8NCM8,Q9BW83,Q8WWQ0,O00330,P16435,Q15019 6 +Cardiac chamber morphogenesis 0.3530876816435424 0.2639580078524895 0.7918122763480362 1.0 1.0 9 Q15648,Q12948 2 +Positive regulation of telomerase activity 0.3333784315605831 0.2636675430739378 0.7920361075888183 1.0 1.0 14 P78371 1 +Midbody abscission 0.3797880073313896 0.2632383288136677 0.7923668901189944 1.0 1.0 6 Q8WUX9 1 +Forebrain cell migration 0.3384752417069829 0.2623568255265216 0.7930463553506897 1.0 1.0 12 P50542,Q9NQC3,Q96N66 3 +Microtubule based transport 0.3014207643544699 0.2616243641633933 0.7936110582119644 1.0 1.0 49 P33176,Q9P1Y5,Q8NCM8,Q9BW83,O94901,P78559,Q92572,P46821,P62820,P05067,Q15154,Q14168,P43034,Q15554,P42858 15 +Transport along microtubule 0.3014207643544699 0.2616243641633933 0.7936110582119644 1.0 1.0 49 P33176,Q9P1Y5,Q8NCM8,Q9BW83,O94901,P78559,Q92572,P46821,P62820,P05067,Q15154,Q14168,P43034,Q15554,P42858 15 +Negative regulation of epithelial cell proliferation 0.3382543184508629 0.2614722786081619 0.79372832459326 1.0 1.0 12 Q12904,Q15648,Q00534,P52758 4 +Negative regulation of striated muscle cell differentiation 0.4431554524361888 0.2612086307075975 0.793931622765679 1.0 1.0 4 O94826,Q13547,P67809 3 +Protein k63 linked ubiquitination 0.3280181014002704 0.2611910134692572 0.7939452078689904 1.0 1.0 16 Q96J02,Q96FW1,P14373,P19474,Q9Y263 5 +Protein localization to chromosome centromeric region 0.3381595783927252 0.2610932363486619 0.794020607444957 1.0 1.0 12 Q96DY7,P49711 2 +Positive regulation of protein depolymerization 0.44283240153573 0.2604120771245504 0.7945459280452463 1.0 1.0 4 Q9Y281,P48681 2 +Epidermal cell differentiation 0.3066165440695709 0.2590587399778954 0.7955899190127738 1.0 1.0 30 Q15648,Q9Y6M7,P43034,Q16739,Q12948 5 +Regulation of developmental growth 0.3046079257465716 0.2584620737950178 0.796050315459387 1.0 1.0 46 O14786,P11802,P16989,Q9UGN5,P46821,Q6IBS0,O95470,P50542,P05067,Q9NQC3,P43034,Q9Y263,O75844,Q12948 14 +Endosomal vesicle fusion 0.5859556144418793 0.2573835234815341 0.7968827209021816 1.0 1.0 2 Q8WUH2 1 +Positive regulation of erythrocyte differentiation 0.3410824307593841 0.256332782875186 0.7976938855752069 1.0 1.0 10 Q15648 1 +Protein dephosphorylation 0.2770686174204292 0.2561088563950502 0.797866783583896 1.0 1.0 62 P63167,Q9Y217,Q8NFC6,P04062,Q13362,Q86XL3,P10586,Q8IV63,Q8WUK0,Q6PIU2,P42858 11 +Regulation of erythrocyte differentiation 0.3315444590738082 0.2558177084689707 0.7980915994103985 1.0 1.0 14 O43251,Q15648 2 +Regulation of t cell proliferation 0.3343251922733193 0.255769974628582 0.7981284596698499 1.0 1.0 13 Q96J02,P09429,P49366 3 +Nucleobase metabolic process 0.3040306003025362 0.2545179118128995 0.7990954679837896 1.0 1.0 23 P30085,P42345,P22102,Q9NRF8,Q02252,P17812,Q9BPU6 7 +Monocyte chemotaxis 0.3637048523420705 0.254079718645624 0.7994339715171179 1.0 1.0 8 Q4KMQ2 1 +Negative regulation of cell aging 0.3907995639460864 0.2533889375762216 0.7999676753239084 1.0 1.0 5 Q00534 1 +Positive regulation of tumor necrosis factor superfamily cytokine production 0.3383587547304432 0.2532069647471555 0.8001082847621046 1.0 1.0 11 P05067 1 +Fatty acid biosynthetic process 0.3026006290085403 0.2519533274209085 0.8010771394955765 1.0 1.0 27 Q9NZ01 1 +Nucleoside triphosphate biosynthetic process 0.3081252894534686 0.2515681963420904 0.8013748437746693 1.0 1.0 36 O75414,P00403,Q9NRF8,P00846,O75964 5 +Myeloid cell homeostasis 0.3077039669514256 0.2497076276438906 0.8028134590310683 1.0 1.0 39 O43251,Q15648,P09601 3 +Positive regulation of hydrolase activity 0.3034461912670858 0.2492028801932856 0.8032038516242279 1.0 1.0 88 P63167,P07602,P09429,Q9NZJ7,O75915,Q15042,Q9Y5X1,Q8IV63,P05067,Q9HAD4,Q9Y4G8,Q96A26,Q66K14,Q9P258 14 +Neutrophil mediated immunity 0.437852171030815 0.2483004695646451 0.8039019357199713 1.0 1.0 4 P51809,O00186,O75083 3 +Positive regulation of mitotic cell cycle phase transition 0.3069855461234392 0.2472668565545539 0.8047017071335769 1.0 1.0 34 Q7L2J0,Q9UJX4,P11802,P30260,Q13042,P06493,P05067,Q96DY7,P35241,Q9BTC8,Q9P258 11 +Oligosaccharide metabolic process 0.3743372606311449 0.2471110502888778 0.8048222819936957 1.0 1.0 6 P10253,P15291,P06280 3 +Regulation of cardiac conduction 0.4368743884835195 0.2459599494779156 0.8057132359142476 1.0 1.0 4 P16615 1 +Epidermis development 0.3053818276057489 0.2457452725353093 0.8058794241669047 1.0 1.0 43 Q15648,Q08J23,Q9Y6M7,P43034,Q16739,O75844,Q12948 7 +Regulation of telomerase activity 0.3171398824947736 0.2438946188380849 0.8073124369034401 1.0 1.0 19 Q96T60,P22626,P78371,Q13315,Q15185 5 +Mapk cascade 0.3017660855077604 0.242923816903867 0.8080644148919982 1.0 1.0 87 Q96J02,Q8IV63,Q9Y4G8,Q96AC1,Q13641,P18615,O14786,P30086,P05067,P43034,Q53EL6,P29372,Q96KB5,Q99873,P09429,O00560,P31689,P04062,O75915,Q9Y3S1,Q96S59,P78318 22 +Tubulin deacetylation 0.3868262642835736 0.2426590193945423 0.8082695564415308 1.0 1.0 5 Q09472 1 +Regulation of ubiquitin dependent protein catabolic process 0.2988889005932894 0.242090245584796 0.8087102363303198 1.0 1.0 49 P46379,O00560,Q86UE8,P04062 4 +Exonucleolytic catabolism of deadenylated mrna 0.3464969180469444 0.2411364154391181 0.8094493899113671 1.0 1.0 9 Q9NQT4,Q15024,Q9Y2L1,Q9NQT5,Q96B26 5 +Positive chemotaxis 0.3718220789325786 0.2398238297966298 0.8104668324867861 1.0 1.0 6 P09429,O14786 2 +Regulation of response to endoplasmic reticulum stress 0.3126339729892126 0.2370958291699954 0.8125824479714319 1.0 1.0 20 P46379,Q92905,O00330,O94966,Q96HY6,P57088 6 +Extrinsic apoptotic signaling pathway 0.3053774622446784 0.2370850221944869 0.8125908317148087 1.0 1.0 34 O14786,Q86WB0,Q9UGN5,P09601,Q8IWB1,P48507,P26583,P42858 8 +Cellular response to steroid hormone stimulus 0.2936789893155561 0.2366894641971552 0.8128977091020535 1.0 1.0 52 Q15648,O43251,O15118,Q9NUQ7,Q9H7B4,O15173 6 +Positive regulation of vacuole organization 0.3705107309791465 0.2360637784006986 0.813383180319154 1.0 1.0 6 Q8TBX8 1 +Negative regulation of developmental growth 0.3446037822174785 0.2347227085686764 0.8144239611856243 1.0 1.0 9 Q9NQC3 1 +Regulation of potassium ion transport 0.3288907210341151 0.2336998293251422 0.8152180202639048 1.0 1.0 13 Q12955,Q4KMQ2,Q9Y3S1 3 +Protein processing involved in protein targeting to mitochondrion 0.5639496355202125 0.2311354957080925 0.8172095400317265 1.0 1.0 3 Q10713,Q99797 2 +Cellular response to leucine starvation 0.563929672153086 0.2310967402001872 0.8172396475284853 1.0 1.0 3 P42345 1 +Negative regulation of developmental process 0.3103937728674322 0.2308821279411699 0.8174063754947534 1.0 1.0 97 P02786,Q15022,Q00534,Q9Y4G8,Q96AC1,Q15554,Q9P258,P16989,Q8N4Q0,P05067,Q9NQC3,Q53EL6,O94966,Q96G23,Q12948,Q99873,Q4VCS5,Q86X55,P09429,Q9UPY3,Q15648,P26358,Q96TA1,Q9NP50 24 +Proteasomal protein catabolic process 0.3538612579557628 0.2307137364654976 0.8175372012446742 1.0 1.0 145 Q96J02,P62191,Q15366,P49720,P78559,Q13362,Q9BUN8,Q13042,Q06787,Q9UBV2,Q13309,Q93009,Q96HY6,Q9H1I8,P60900,P28070,O00487,P30260,P20618,Q5TDH0,Q9UBU6,P49721,Q15058,Q6ZXV5,O94966,P46379,O75150,O94822,Q96KB5,Q9GZP9,O60524,Q8TCT9,P63244,O00560,Q13617,Q96P47,Q86UE8,Q9HCN8,P04062,Q9UJX4,Q9UL46,P28074,P25788,O94888,Q92890,Q9Y263,Q5VYK3 47 +Dna unwinding involved in dna replication 0.3255577340386599 0.2306698336822163 0.8175713107814484 1.0 1.0 14 P49736,P27694,P46063,P33992,Q14566,P33993,Q96RR1 7 +Activation induced cell death of t cells 0.5636510068516867 0.230556193036621 0.817659603593794 1.0 1.0 3 P62753 1 +Camera type eye development 0.3026933040536914 0.2305226447551103 0.8176856692886343 1.0 1.0 31 Q9H0D6,O14786,Q15648,Q9UPY5,Q15042,P54802,P08670,P83731,Q12948 9 +Positive regulation of cell cell adhesion mediated by cadherin 0.4302287040105996 0.2303818434783001 0.8177950685392592 1.0 1.0 4 O75955,P41440,P55196 3 +Regulation of myeloid cell apoptotic process 0.430096630101788 0.2300781221277152 0.8180310649019003 1.0 1.0 4 P14174,Q9UPY5 2 +Defense response to symbiont 0.2852039677965329 0.2294116360917463 0.8185489930193355 1.0 1.0 56 Q96J02,Q7Z7L1,Q9Y3Z3,Q9HCE1,Q9NQT4,Q9H2U1,P14373,P07900,O14802,P19474,Q92890,O43657,Q9Y4E8,Q9NUD5,O75844 15 +Monocarboxylic acid biosynthetic process 0.3041422302343723 0.2293193555375597 0.8186207107366479 1.0 1.0 34 Q96PU8,Q9NZ01,P22059,Q15185,O00154,P49748,O60678,O95864 8 +Maintenance of synapse structure 0.3669080957730717 0.2258742297862918 0.821299241535359 1.0 1.0 6 Q15334 1 +Regulation of presynaptic cytosolic calcium ion concentration 0.5609675281643464 0.2253924268552112 0.8216740025814786 1.0 1.0 3 Q00535,P23634 2 +Protein containing complex localization 0.3023413703276673 0.2244041322567154 0.8224428556019876 1.0 1.0 43 P33176,Q9BW83,Q86U38,Q13315,Q15334,Q9BTX1,P62841,Q14168,Q15554,P62826,Q9P258 11 +Pigment biosynthetic process 0.3027933059361453 0.2242900487739246 0.8225316189062144 1.0 1.0 22 Q9Y4G8 1 +Regulation of keratinocyte differentiation 0.352457658887121 0.2185000637688786 0.8270395086379325 1.0 1.0 8 Q15648 1 +Regulation of epidermis development 0.352457658887121 0.2185000637688786 0.8270395086379325 1.0 1.0 8 Q15648 1 +Fructose 1 6 bisphosphate metabolic process 0.4249254226052241 0.2183682515444741 0.8271422002329529 1.0 1.0 4 Q01813,P17858,P08237 3 +Visual behavior 0.3641358189638805 0.2181750199069232 0.82729274749316 1.0 1.0 6 P05067,Q9UPY5 2 +Peptidyl tyrosine dephosphorylation 0.3249452892485662 0.2180562972544938 0.8273852477616952 1.0 1.0 13 P10586,Q9Y217 2 +Positive regulation of filopodium assembly 0.3639188813837163 0.2175777915052799 0.8277580897595862 1.0 1.0 6 O14786 1 +Trna transcription 0.3645561778257419 0.2172353617149294 0.8280249279584473 1.0 1.0 7 Q969F1 1 +Divalent inorganic cation homeostasis 0.2956195497227059 0.2172242899960802 0.828033555919844 1.0 1.0 49 Q9BPX6,Q12955,Q15334,P05067,Q9HD20,P78417,P42858 7 +Negative regulation of catabolic process 0.3047834985996429 0.2154740266191072 0.8293977602144031 1.0 1.0 93 P46379,Q86UE8,Q96KB5,P16989,P09601,O15118,Q16850,P10619,O00560 9 +Positive regulation of catabolic process 0.3419541352218124 0.2151457082680572 0.8296537181696582 1.0 1.0 133 Q96J02,O00443,P21796,Q86UE4,Q9NQT4,P09601,Q9Y5X1,Q15042,Q13315,Q9NZN8,P42858,Q9HCE1,Q15024,P19474,P05067,Q6ZXV5,O15269,P46379,O75150,Q9H2U1,Q9UII2,O15514,P09429,P54646,Q9HBH5,P04062,Q8TBX8,P52758,Q92945,Q9NQT5 30 +Coenzyme a biosynthetic process 0.3629685203072826 0.2149704901959003 0.8297903260968871 1.0 1.0 6 O00154 1 +De novo pyrimidine nucleobase biosynthetic process 0.3625626563248532 0.2138615036891591 0.830655061276067 1.0 1.0 6 P30085 1 +Immune response regulating signaling pathway 0.2963295995644506 0.2133400657247838 0.8310617248728591 1.0 1.0 48 P46379,Q09472,Q9NPR9,Q9NQC3,P09429,O43657,Q9Y4E8,Q9NUD5 8 +Response to potassium ion 0.3754515414935894 0.2132555803408819 0.8311276183341068 1.0 1.0 5 Q15334 1 +Cellular response to potassium ion 0.3754515414935894 0.2132555803408819 0.8311276183341068 1.0 1.0 5 Q15334 1 +Actin filament depolymerization 0.3105850486295024 0.212439290542303 0.8317643358153728 1.0 1.0 19 P47755,Q9UEY8,P52907,Q9Y281,Q6IBS0,Q13045,P35241,P35611,O75083 9 +Negative regulation of innate immune response 0.3376711892933648 0.2117935364959489 0.8322681112700734 1.0 1.0 9 Q9Y3Z3 1 +Endoplasmic reticulum unfolded protein response 0.3069291088406339 0.2090108038858506 0.834439804602066 1.0 1.0 20 Q09472,Q7Z2K6,Q92905,Q9BUN8,Q9GZP9,P63244,Q96HY6,P57088 8 +Synaptic signaling 0.2898460927255948 0.2081524446718823 0.8351099389068308 1.0 1.0 79 P43034,Q99808,P50897,Q9BVA1,Q15042,Q9NR77,Q15334,P05067,Q9Y4G8,Q9UQB8,Q13641,O00560 12 +Positive regulation of cell cycle g2 m phase transition 0.3223087393509245 0.2077862129855737 0.8353958981164589 1.0 1.0 13 P11802,P05067 2 +Regulation of mitotic cell cycle phase transition 0.2876301935649425 0.2067790262649921 0.8361824367663009 1.0 1.0 77 Q7L2J0,Q6NUQ1,P11802,Q96K76,Q13042,Q68E01,Q13315,Q96DY7,Q13257,Q9P258,P30260,P49454,P05067,Q15058,Q969U7,P15927,Q7Z7L1,P35241,Q9BTC8,Q9UJX4,P61254,O14757,O43684,P06493,P19447,Q9Y619 26 +Protein k48 linked ubiquitination 0.3267309396474349 0.2050665371762856 0.8375201402879142 1.0 1.0 10 Q96J02,Q15386 2 +Regulation of peptidyl lysine acetylation 0.3135131516810097 0.2046098023645455 0.8378769962536123 1.0 1.0 17 O75844 1 +Non canonical wnt signaling pathway 0.3591367861647959 0.2046085398460553 0.8378779827305998 1.0 1.0 6 P63000,Q8TAA9 2 +Protein localization to chromosome 0.2990796578426949 0.2018782943390085 0.8400118713128684 1.0 1.0 43 O14773,P78371,Q96DY7,P49711 4 +Adenylate cyclase inhibiting g protein coupled receptor signaling pathway 0.3345272867980909 0.2016910155203864 0.8401582868373652 1.0 1.0 9 P07602 1 +Mitotic cell cycle phase transition 0.3187174989487955 0.2016016527021085 0.8402281530886033 1.0 1.0 109 P08183,Q9Y6A5,Q7L2J0,Q6NUQ1,P11802,Q96K76,Q13042,Q68E01,Q13315,Q07864,Q13309,Q96DY7,Q00534,Q07666,Q8WUX9,Q13257,Q9P258,Q7Z460,P30260,P49454,P48681,P05067,Q15058,Q969U7,P83731,P15927,Q7Z7L1,O00743,P35241,Q9BTC8,Q13617,Q9UJX4,P61254,O14757,O43684,P06493,P19447,Q9Y619 38 +Positive regulation of mononuclear cell migration 0.3343967825787508 0.2012757258652877 0.8404829821058322 1.0 1.0 9 P05067,Q4KMQ2 2 +Ruffle organization 0.3182884682738991 0.2011599822645903 0.8405734813718442 1.0 1.0 14 P42345,P07737,P63000,P35241,P35080,Q9P258 6 +Biological process involved in symbiotic interaction 0.2816901572775715 0.2001482368753613 0.8413646489465938 1.0 1.0 72 Q14108,Q8WTV0 2 +Regulation of alpha beta t cell activation 0.3338887593987828 0.1996622081031603 0.8417447721475146 1.0 1.0 9 P09429 1 +Cellular response to ketone 0.3122626654007868 0.1991276689963443 0.8421628778838111 1.0 1.0 17 Q9H7B4 1 +Cytoplasmic sequestering of nf kappab 0.5461549843682271 0.1982560104192452 0.8428447670969548 1.0 1.0 3 O75832 1 +Cellular polysaccharide catabolic process 0.3577467503798345 0.1981372454302747 0.8429376848153403 1.0 1.0 7 P10253 1 +Polysaccharide catabolic process 0.3577467503798345 0.1981372454302747 0.8429376848153403 1.0 1.0 7 P10253 1 +Cellular response to inorganic substance 0.2993198264080997 0.1973077836800144 0.8435866885818157 1.0 1.0 41 Q12955,P09601,Q15334,P35611,P05067,Q92542,O15111,Q14168,Q9BY42,Q9UNS1 10 +Response to hydroxyurea 0.3572630455882429 0.1968099485051883 0.843976265602056 1.0 1.0 7 Q9BY42,Q9UNS1,Q06787 3 +Regulation of dendritic spine morphogenesis 0.3212091636628802 0.1961540615788332 0.844489583042813 1.0 1.0 12 Q9UQB8 1 +Cellular response to vascular endothelial growth factor stimulus 0.3557519394276972 0.1956577248503923 0.8448780754642422 1.0 1.0 6 Q12948 1 +Regulation of viral entry into host cell 0.355444466475734 0.1948541594802075 0.8455071216735146 1.0 1.0 6 P14373,P19474 2 +Negative regulation of binding 0.2948834507639158 0.1944482079489347 0.8458249457053022 1.0 1.0 29 P10586,P09601 2 +Atp synthesis coupled electron transport 0.2991147360679582 0.1941345530374333 0.8460705268563409 1.0 1.0 36 Q9Y6M9,P03886,P00403,O14949,Q9UDW1 5 +I kappab phosphorylation 0.3671707042860739 0.1931110863899718 0.8468719703950274 1.0 1.0 5 O15111 1 +Regulation of signaling receptor activity 0.3136474235790312 0.1927901105328001 0.8471233488482912 1.0 1.0 15 Q15334,O14786,Q9UNH7,P05067 4 +Positive regulation of mitochondrial translation 0.3436986366684842 0.1923050931458115 0.8475032291046385 1.0 1.0 8 Q96SZ6,Q567V2 2 +Protein repair 0.5525008280887836 0.1917575129330788 0.8479321530342203 1.0 1.0 2 P22061 1 +Regulation of protein acetylation 0.3061092247340054 0.1915870226553916 0.8480657086234378 1.0 1.0 19 O75844 1 +Inositol phosphate metabolic process 0.3660477453580905 0.1904629834621428 0.8489463471300096 1.0 1.0 5 O95861,Q01968,Q10713,Q9UNW1 4 +Response to molecule of bacterial origin 0.2986598894100435 0.1897981205764595 0.8494673286905297 1.0 1.0 38 Q53EL6,Q8WTV0 2 +Immunoglobulin production 0.3027220280042723 0.1888526510700157 0.8502083046614886 1.0 1.0 20 Q9NQT5,Q9Y3Z3,Q9UQ84,P52701 4 +Cell morphogenesis involved in differentiation 0.3292078078910885 0.1879260197741506 0.8509346452894819 1.0 1.0 122 P43034,Q09472,Q9BVA1,Q12955,P42892,Q15334,Q96TA1,P05067,P83731,Q9Y4G8,Q9NQC3,Q9UQB8,Q13641,Q96AX1,Q13509,O43251,Q9P258 17 +Regulation of amyloid precursor protein catabolic process 0.3188530676863952 0.1876033319664119 0.8511876140924584 1.0 1.0 12 Q9NQC3,O95197 2 +Developmental pigmentation 0.3526091981309218 0.1875195552615162 0.8512532927472583 1.0 1.0 6 Q96AX1 1 +Free ubiquitin chain polymerization 0.5498509440212117 0.1871483800974998 0.8515442963726496 1.0 1.0 2 Q16763 1 +Cellular glucose homeostasis 0.2915473743836267 0.1868607099177815 0.85176984548056 1.0 1.0 23 Q15120,Q99808,O00330,P22059,P55809,P48507,P63244,Q96RR1,P54646 9 +Response to muramyl dipeptide 0.5393286811524021 0.1865367239198636 0.852023882686467 1.0 1.0 3 P08670 1 +Positive regulation of neuron differentiation 0.3211459540723373 0.1862285210356717 0.8522655586133476 1.0 1.0 10 P46821,Q8WUJ1,Q92974,Q9H8V3,Q99829 5 +Endosomal transport 0.273740379286384 0.185597617073127 0.8527603223994398 1.0 1.0 66 Q2M389,Q9Y5X1,Q9UBQ0,O75503,Q8WUX9,P49257,Q9H4M9,O15260 8 +Synaptic vesicle localization 0.3196688834238416 0.1851738837104345 0.8530926526143228 1.0 1.0 11 P33176,Q92572 2 +Relaxation of cardiac muscle 0.5384605350232221 0.185082086440199 0.8531646518153979 1.0 1.0 3 P05026 1 +Response to manganese ion 0.4090293059617931 0.1846341927246682 0.8535159650864541 1.0 1.0 4 P05067 1 +Regulation of mammary gland epithelial cell proliferation 0.5374700288706598 0.1834323024832182 0.8544588321197364 1.0 1.0 3 Q9NQC3 1 +Regulation of establishment or maintenance of cell polarity 0.3501928176283605 0.1813764063986715 0.8560721366949526 1.0 1.0 6 P63244,Q15334 2 +Nuclear envelope organization 0.29019809542946 0.1806042181628729 0.8566782447178638 1.0 1.0 27 Q86XL3,O75844 2 +Interleukin 2 production 0.3395287089279907 0.1803196017269505 0.8569016679396977 1.0 1.0 8 P00491,P04083,P14373,Q92990,Q9UJZ1,P23396,P15311 7 +Positive regulation of receptor internalization 0.5353214345799506 0.1798898093572726 0.8572390756487602 1.0 1.0 3 Q96CW1 1 +Nucleoside triphosphate metabolic process 0.2914990914605972 0.178016214831014 0.8587102415372425 1.0 1.0 48 Q9Y3Z3,P00846,O75964,Q9NRF8 4 +Regulation of actin filament based process 0.2885543281318086 0.1778501728918727 0.858840643139593 1.0 1.0 81 P63167,P52907,Q9Y5X1,Q14019,P63000,Q13045,O15145,Q96AC1,P35080,Q9H8V3,P47755,O14786,P50552,Q7Z460,Q9NUQ9,P07737,Q13576,Q9UQB8,Q14247,P42345,Q6IBS0,P35241,Q68EM7,P16615,O75083,P52565,Q9UEY8,Q9Y281,P14373,P35611 30 +Negative regulation of atp dependent activity 0.3604111405835531 0.1774770948828009 0.8591336552661466 1.0 1.0 5 P33993,P49736,Q9UII2,P04637 4 +Regulation of carbohydrate metabolic process 0.2937287098169976 0.1773816842812262 0.859208593014936 1.0 1.0 31 Q14108,O75844 2 +Ribosomal subunit export from nucleus 0.3172781430954218 0.1769964984183872 0.8595111400135549 1.0 1.0 11 Q86U38,P62826 2 +Multi multicellular organism process 0.2893739424955746 0.1755647900507652 0.8606358660982492 1.0 1.0 23 P35613,Q96GC9,Q9UIQ6,Q15648 4 +Regulation of dephosphorylation 0.2924118292460198 0.1748010005755624 0.8612360020978698 1.0 1.0 30 P63167,Q8NFC6,P42345,P04062,Q86XL3,Q8IV63,P42858 7 +Cellular response to osmotic stress 0.3165911667452218 0.1746697997650211 0.8613390992193577 1.0 1.0 11 Q9BPX6 1 +Regulation of cytoplasmic translation 0.3090485695275988 0.1742443873217132 0.8616734030173796 1.0 1.0 15 P11940,P42345,O75534,P16989,Q9H2U1,P40429,Q9NZI8,O60506,Q06787,P67809,Q08211,P14618,Q00839,Q14103 14 +Negative regulation of ubiquitin protein transferase activity 0.3160516244209508 0.1728497099368726 0.8627695621838742 1.0 1.0 11 Q13257,P62841 2 +Gmp salvage 0.5308151093439314 0.1726210626299698 0.8629492948502648 1.0 1.0 3 P07741,P55263 2 +Positive regulation of dendrite morphogenesis 0.3168009021156729 0.1720258499720098 0.8634172065939492 1.0 1.0 10 Q9UQB8 1 +Amyloid beta metabolic process 0.315797933407706 0.1719961264508984 0.8634405742640232 1.0 1.0 11 Q9NQC3 1 +Response to insulin 0.278289716122408 0.17170128112355 0.8636723785823128 1.0 1.0 56 Q9BSK2,O00443,P43490,P11802,Q8TBX8,Q9UQB8 6 +Positive regulation of cell cycle checkpoint 0.4016669515048804 0.1701885927526206 0.8648618225156437 1.0 1.0 4 Q13257 1 +Apoptotic process involved in development 0.3453891188850909 0.1694619134863745 0.8654333276821924 1.0 1.0 6 Q12948 1 +Negative regulation of blood circulation 0.5286482255961116 0.1692035387847051 0.8656365463787201 1.0 1.0 3 P16615 1 +Cellular response to alkaloid 0.4010619652127393 0.1690351233526613 0.865769014458484 1.0 1.0 4 O14757 1 +Positive regulation of cellular protein catabolic process 0.2951901013760228 0.1679863302427757 0.866594033142366 1.0 1.0 38 P46379,P04062 2 +Regulation of fatty acid transport 0.3990719257540565 0.1652769936533186 0.8687259661821853 1.0 1.0 4 P33121,P14174,P07814 3 +Protein modification by small protein removal 0.2944120685676026 0.165169543116995 0.8688105370535433 1.0 1.0 41 Q96J02,O95630,Q96FW1,Q86UV5,Q96K76,Q92905,Q99627,P19474,P06493,P51784,Q15018,Q93009,O94966,Q9Y4E8,Q9BT78 15 +Cell differentiation involved in embryonic placenta development 0.5362702881749055 0.1648881559442466 0.8690320149830582 1.0 1.0 2 Q13043 1 +Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.5359390526664589 0.1643736002637639 0.8694370448239233 1.0 1.0 2 Q13043 1 +Positive regulation of dendritic spine morphogenesis 0.3337034281362303 0.1641150522819625 0.8696405724678942 1.0 1.0 8 Q9UQB8 1 +Axoneme assembly 0.5248508946322017 0.1633361772092273 0.8702537510685353 1.0 1.0 3 A0AVF1,Q15555 2 +Regulation of microtubule based movement 0.3973377208557477 0.16204718666996 0.8712686953060869 1.0 1.0 4 Q9Y6A4,P78318 2 +Negative regulation of growth 0.2852218676547876 0.1605953940616816 0.87241208281685 1.0 1.0 26 P50897,Q9NQC3 2 +Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.522862823061625 0.1603260874440676 0.872624209867918 1.0 1.0 3 Q86VN1,Q92783 2 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.3074903399314678 0.1595398369036567 0.8732435749185552 1.0 1.0 14 Q96A26,Q9NZJ7 2 +Regulation of rho protein signal transduction 0.3108099042456805 0.1593443308627633 0.8733975959306692 1.0 1.0 12 P63167,P63000,O14786,P52565 4 +Ruffle assembly 0.3126532767422621 0.1588479901873902 0.873788638090438 1.0 1.0 10 P07737,P63000,P35241,P35080,Q9P258 5 +Dna double strand break processing 0.351477869876986 0.1579540345525184 0.8744930190341609 1.0 1.0 5 Q9H4L7 1 +Regulation of t cell receptor signaling pathway 0.3950944647000282 0.157931827697892 0.874510517910519 1.0 1.0 4 P51452,P23396,P15311 3 +Regulation of receptor signaling pathway via stat 0.3420703384206979 0.157161326960501 0.8751177060987276 1.0 1.0 7 Q00535,Q13043,Q13610,Q6IA86,P30153,Q9NX40 6 +Exocytosis 0.2715532071474962 0.1564668071268415 0.8756650810422331 1.0 1.0 67 O00443,Q7Z460,P09601,Q15042,O43760,Q15334,O00560 7 +Guanine metabolic process 0.5306392845313149 0.1563234053164276 0.8757781083538125 1.0 1.0 2 O60341 1 +Imp salvage 0.530639284531315 0.1563234053164276 0.8757781083538125 1.0 1.0 2 P07741 1 +Embryonic organ development 0.2903260767908773 0.15625092573715 0.875835236713771 1.0 1.0 46 Q15648,P27635,Q9BVA1,P42892,P54802 5 +Membrane repolarization during cardiac muscle cell action potential 0.3941000994365145 0.1561301946242181 0.8759303983392546 1.0 1.0 4 P62258,P05026,P05023 3 +Membrane repolarization during action potential 0.3941000994365145 0.1561301946242181 0.8759303983392546 1.0 1.0 4 P62258,P05026,P05023 3 +Positive regulation of interleukin 2 production 0.3393034825870602 0.1549444486765833 0.8768651117859316 1.0 1.0 6 P00491,P04083,Q92990,Q9UJZ1,P23396 5 +Actin filament severing 0.3402189492777749 0.1526056488850759 0.8787092700172412 1.0 1.0 7 Q13045 1 +Regulation of oligodendrocyte differentiation 0.3382016566997992 0.152385627455702 0.8788827923193272 1.0 1.0 6 O14744,P42345 2 +Positive regulation of cytoplasmic translation 0.3087404453306805 0.1523124400740754 0.8789405136366941 1.0 1.0 12 P11940,O75534,P16989,Q9H2U1,O60506,Q9NZI8,P67809,Q08211,P14618,Q00839,Q14103 11 +Regulation of insulin receptor signaling pathway 0.3079474800184454 0.1496444600077826 0.8810451290900618 1.0 1.0 12 P11802 1 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3086378737541549 0.1484982745700691 0.8819495475529919 1.0 1.0 11 P11940,O75534,Q9NZI8,Q9H2U1,A5YKK6,O60506,P67809,Q08211,Q00839,Q14103 10 +Ether biosynthetic process 0.3464854111405829 0.1476151051256848 0.882646533537538 1.0 1.0 5 P49327,Q6IAN0,O00116,Q8WVX9 4 +Ubiquitin dependent endocytosis 0.5243458098708288 0.1472080966430854 0.8829677700264804 1.0 1.0 2 Q99816 1 +Regulation of endoplasmic reticulum unfolded protein response 0.3375659280159612 0.1461840106816746 0.8837761275880127 1.0 1.0 7 Q92905,Q96HY6,P57088 3 +Positive regulation of immune effector process 0.2885400049876711 0.1432970636761871 0.8860555747484344 1.0 1.0 32 P09601 1 +Cellular response to ionizing radiation 0.2951821483810438 0.142966274869311 0.8863168162914605 1.0 1.0 19 O75844 1 +Lipid export from cell 0.5102717031146402 0.1422442444420177 0.8868870850620842 1.0 1.0 3 P14174,O15439 2 +Establishment of protein localization to organelle 0.3585400181798949 0.1410343157443202 0.887842833228484 1.0 1.0 163 A5D8V6,Q99595,Q15042,Q14108,Q8N4H5,P49257,Q9NS69,O60830,P49458,P55060,O14925,P46379,Q15629,P78371,Q5JRX3,Q9Y512,Q9UBE0,Q15648,P20645,P50542 20 +Establishment of golgi localization 0.5086149768058263 0.1399907714107008 0.8886672819334336 1.0 1.0 3 Q9Y678,P63104 2 +Cranial nerve development 0.5079821812931111 0.1391377202516463 0.889341321659149 1.0 1.0 3 P83731 1 +Regulation of t cell differentiation 0.3131126020169562 0.1380697064172814 0.8901853272164275 1.0 1.0 9 O96005 1 +Negative regulation of nitric oxide synthase activity 0.5066841406468872 0.1374011297516116 0.8907137381051891 1.0 1.0 3 P06280 1 +Negative regulation of monooxygenase activity 0.5066841406468872 0.1374011297516116 0.8907137381051891 1.0 1.0 3 P06280 1 +Negative regulation of oxidoreductase activity 0.5066841406468872 0.1374011297516116 0.8907137381051891 1.0 1.0 3 P06280 1 +Regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.2807446897299215 0.1369151529843927 0.8910978612836953 1.0 1.0 26 Q9Y3F4,Q09472,Q93062,Q92896,O00560,Q9UNH7 6 +Negative regulation of meiotic cell cycle 0.516396157668116 0.1363760468818824 0.8915240085694343 1.0 1.0 2 Q15645 1 +Meiotic cell cycle phase transition 0.5163961576681158 0.1363760468818821 0.8915240085694345 1.0 1.0 2 O95067 1 +Coenzyme a metabolic process 0.3229024881711799 0.1357759443963921 0.8919984085203008 1.0 1.0 8 Q9NVE7,Q8WVC6,O00154 3 +Isopentenyl diphosphate biosynthetic process 0.5053015241881987 0.1355709619465979 0.8921604624804971 1.0 1.0 3 Q03426,Q15126 2 +Bile acid and bile salt transport 0.5157336866512213 0.1355073980129105 0.8922107154400432 1.0 1.0 2 P28288 1 +Regulation of translational elongation 0.3291336043146263 0.1321464623748076 0.8948684464644296 1.0 1.0 6 P49458 1 +Response to fatty acid 0.3033903144562218 0.1320204675198979 0.8949681027078231 1.0 1.0 11 P11802,O00330,Q15120,P50416 4 +Telomere capping 0.2995699891047277 0.1308031860238514 0.8959310025709091 1.0 1.0 14 Q96T60,Q13315 2 +Pigmentation 0.2992205896662627 0.1295718537512568 0.8969051729355602 1.0 1.0 14 Q96AX1,P62820,Q9BXS5,Q8TAA9 4 +Protein o linked glycosylation via threonine 0.5104339185160761 0.1287445716041951 0.8975597658276222 1.0 1.0 2 Q10471 1 +Regulation of endocytosis 0.2870068163915751 0.1251221887573705 0.9004268172485714 1.0 1.0 44 O00560,P05067,P50897,Q4KMQ2 4 +Calcium ion export across plasma membrane 0.5074527989400589 0.1250849228803746 0.9004563193436239 1.0 1.0 2 P20020 1 +Cell cycle g2 m phase transition 0.2869301830477679 0.1246267097781847 0.9008190819037224 1.0 1.0 44 P08183,Q6NUQ1,P11802,Q96K76,Q68E01,Q13315,Q13309,Q07666,P14635,Q9P258,P49454,P48681,P05067,Q15058,Q96ST3,Q9NWV8,P53350,Q9BTC8,O14757,P06493,Q9Y619 21 +Negative regulation of mitotic cell cycle 0.2837981271409291 0.1237819794916711 0.9014879003531902 1.0 1.0 48 Q7Z7L1,Q12948,Q6NUQ1,Q96K76,P49454,P61254,O14757,Q68E01,O43684,P06493,Q13315,P43246,Q96DY7,O75414,Q9Y619,Q13257,P15927,Q9NVX2 18 +Epithelial cell differentiation 0.3003223169185277 0.1233502466560938 0.901829753520092 1.0 1.0 99 P21796,Q15648,Q9Y6M7,O14773,P07437,Q9Y4G8,P49748,O43598 8 +Regulation of cell cycle g1 s phase transition 0.2848951363968455 0.1230489985518445 0.9020682975158644 1.0 1.0 32 Q7Z7L1,Q7L2J0,P61254,Q13315,P35241,Q96DY7,Q15058,Q96HY6,P15927 9 +Vitamin biosynthetic process 0.4953487035500382 0.1229882198283203 0.902116426358856 1.0 1.0 3 O00764 1 +Water soluble vitamin biosynthetic process 0.4953487035500382 0.1229882198283203 0.902116426358856 1.0 1.0 3 O00764 1 +Immune response regulating cell surface receptor signaling pathway 0.2746887998664095 0.121915221898493 0.9029661602246808 1.0 1.0 24 Q9NR50,P46379,Q09472,P61088,Q07666,P49770 6 +Post chaperonin tubulin folding pathway 0.3315649867373981 0.1191846898940236 0.9051290358816042 1.0 1.0 5 Q15814,Q9BTW9,Q15813,O75347 4 +Golgi organization 0.2860401190794767 0.1188911672491626 0.9053615796411554 1.0 1.0 44 P40616,Q9P1Y5,Q8NCM8,Q92538,O14744,Q7Z460,Q96GC9,P06493,P62820,P27361,P49257,Q12907,P42858,O15260 14 +Regulation of neurotrophin trk receptor signaling pathway 0.5021530308049167 0.1188322778361046 0.9054082358458097 1.0 1.0 2 Q7L576 1 +Positive regulation of neurotrophin trk receptor signaling pathway 0.5021530308049167 0.1188322778361046 0.9054082358458097 1.0 1.0 2 Q7L576 1 +Regulation of dna dependent dna replication 0.2871309656992823 0.1185884032569929 0.9056014533744356 1.0 1.0 20 Q7Z7L1,O95785,P40938,Q9UNS1,O75844 5 +Ribonucleoside triphosphate metabolic process 0.287131694401034 0.1185412250396238 0.905638832489561 1.0 1.0 40 P00846,O75964,Q9NRF8 3 +Nucleobase biosynthetic process 0.2936935733988648 0.1184419114657899 0.9057175189246264 1.0 1.0 16 P30085,P42345,P22102,Q9NRF8,P17812 5 +B cell activation involved in immune response 0.2970894363642519 0.1175780479546652 0.9064019994696328 1.0 1.0 13 Q9NQT5,Q9UQ84,P52701 3 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.2970894363642519 0.1175780479546652 0.9064019994696328 1.0 1.0 13 Q9NQT5,Q9UQ84,P52701 3 +Somatic diversification of immunoglobulins involved in immune response 0.2970894363642519 0.1175780479546652 0.9064019994696328 1.0 1.0 13 Q9NQT5,Q9UQ84,P52701 3 +Somitogenesis 0.2986638177162503 0.1172328134248292 0.9066755648400378 1.0 1.0 10 Q09472,Q12948 2 +Lung cell differentiation 0.4904815614273739 0.1172095439601692 0.9066940040655428 1.0 1.0 3 P09960 1 +Gene silencing by rna 0.2865759193682734 0.1171504041606561 0.9067408679440876 1.0 1.0 37 Q9HCE1,P62826,Q9UPY3,Q9UKZ1,Q15631,Q9NZN8,O75844 7 +Inflammasome complex assembly 0.4903466006369556 0.1170527756810182 0.9068182319402264 1.0 1.0 3 P19525 1 +Endosome to lysosome transport 0.2955391980476753 0.1167891604502963 0.9070271336741416 1.0 1.0 14 Q96AX1 1 +Transforming growth factor beta production 0.4998343822457913 0.1161975823883386 0.90749595274977 1.0 1.0 2 P08238 1 +Negative regulation of transforming growth factor beta production 0.4998343822457913 0.1161975823883386 0.90749595274977 1.0 1.0 2 P08238 1 +3 utr mediated mrna stabilization 0.3148276112350901 0.1160755738345783 0.9075926471942206 1.0 1.0 8 Q13148,P16989,Q13151,P98175 4 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.278089283423768 0.1159696831919324 0.9076765689520324 1.0 1.0 27 Q9UQ84,P42345,Q9BY67,P02786,Q9NQT5,P52701,P09429 7 +Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules 0.3693691648362169 0.1157832786661868 0.9078243030685692 1.0 1.0 4 Q9BY67 1 +Protein homooligomerization 0.2863675750309209 0.1145785872556174 0.90877915280719 1.0 1.0 41 Q9BPX6,Q9Y3Z3,P50552,Q99873,Q96CX2,Q14168,Q9H4M9,Q99720 8 +Antigen processing and presentation of lipid antigen via mhc class ib 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Nk t cell differentiation 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Zinc ion homeostasis 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Regulation of nk t cell differentiation 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Antigen processing and presentation via mhc class ib 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Positive regulation of organelle organization 0.3422238614267183 0.1110562541879559 0.911571738184098 1.0 1.0 147 P21796,Q15042,Q9Y5X1,Q13042,Q8WUM4,Q13315,Q9NZN8,Q96AC1,P49257,Q15554,P42858,O14737,O14786,P50552,P22626,P30260,Q7Z460,P46821,P07737,Q16625,Q9UQB8,Q96A26,P42345,Q8WWQ0,Q9H2U1,Q9UII2,P78371,Q9Y6X9,O00560,O15260,Q96T60,Q9HBH5,P22059,P26358,Q8TBX8,Q15003 36 +Small gtpase mediated signal transduction 0.2880167579530717 0.1109827765049281 0.9116300047070808 1.0 1.0 88 P09601,Q9Y4G8,P80303,Q02818 4 +Reactive oxygen species biosynthetic process 0.296403002978077 0.1109289487896399 0.9116726894494188 1.0 1.0 10 P00403 1 +Regulation of microtubule polymerization or depolymerization 0.2826113788847029 0.1106264408577755 0.9119125794033548 1.0 1.0 32 Q9P1Y5,P78559,P04350,Q7Z460,P46821,Q16625,P63000,P29372,Q92974 9 +Transforming growth factor beta receptor signaling pathway 0.2722869251216094 0.1100471532704768 0.9123719790770424 1.0 1.0 24 Q9Y3F4,Q09472,Q9Y4E8,Q92896,Q96AC1,O00560,Q9UNH7 7 +Positive regulation of protein localization to cell surface 0.318265133710738 0.1098355354767862 0.912539808291802 1.0 1.0 6 P78559,Q13277,Q92544 3 +Ribonucleoside monophosphate biosynthetic process 0.2888263139192031 0.1090581012472371 0.913156406967502 1.0 1.0 18 P30085,Q9BZX2,P22102,P30520,Q06203 5 +Positive regulation of cell death 0.3044370088304917 0.1090185757605429 0.913187756823204 1.0 1.0 105 P63167,P09601,Q13315,Q9Y4G8,P42858,Q9NS69,Q7Z3C6,P15291,P00403,Q9Y6C9,Q96A26,Q53EL6,P63241,Q7Z7L1,Q9UHI6,P09429,Q4KMQ2,Q05639,Q9NZJ7,O75915 20 +Positive regulation of dendritic spine development 0.2954686868675029 0.1083587077443125 0.9137111546607928 1.0 1.0 10 Q9UQB8 1 +Synapse organization 0.2670703172685968 0.1082190915003966 0.9138219010657648 1.0 1.0 68 Q12955,Q15334,P07437,P05067,P10586,Q9UQB8,Q13641,O00560 8 +Nucleotide excision repair dna incision 0.3636618647691656 0.1076819535812574 0.9142479852200414 1.0 1.0 4 P19447 1 +Monosaccharide metabolic process 0.2647374380747088 0.1064242499954957 0.915245753619786 1.0 1.0 66 P10253,Q09472,Q9UBX3,P16278,P04066,O43826,Q9BRR6,P78417,O75844 9 +Regulation of transcription involved in g1 s transition of mitotic cell cycle 0.4801192842942289 0.1057104089303129 0.9158121214970778 1.0 1.0 3 Q00535,O60885 2 +Eyelid development in camera type eye 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 1.0 2 Q13547 1 +Response to amphetamine 0.4898973169923966 0.10558674128321 0.9159102448644754 1.0 1.0 2 P00492 1 +Negative regulation by host of viral process 0.4781312127236538 0.1036273355355057 0.9174650938262436 1.0 1.0 3 Q9H1E3,Q9P0L0 2 +Smooth muscle cell chemotaxis 0.4872474329248246 0.102939953841735 0.9180106275391416 1.0 1.0 2 O94813 1 +Regulation of smooth muscle cell chemotaxis 0.4872474329248246 0.102939953841735 0.9180106275391416 1.0 1.0 2 O94813 1 +Mannosylation 0.3179216822106418 0.1026110610977398 0.9182716636965732 1.0 1.0 7 Q2TAA5,Q6ZXV5 2 +Regulation of chromatin assembly 0.293054509859629 0.102342592430567 0.9184847489008268 1.0 1.0 12 Q9Y6X9,P26358,Q96ST3,Q15047 4 +Positive regulation of meiotic cell cycle 0.4865849619079314 0.1022900549359109 0.9185264489134204 1.0 1.0 2 Q8IXJ6 1 +Negative regulation of peptide secretion 0.3596287703016128 0.1022262961945287 0.9185770557447812 1.0 1.0 4 Q06124,Q16836,P17858 3 +Signal release 0.2792701094428514 0.0997065141542686 0.9205773287699625 1.0 1.0 49 P50897,O00330,Q15042,P17858,P50416,Q06787,P56545,P62820,P22059,Q96TA1,P55809,P16615,P53985,Q12904,P35080,Q9UNH7 16 +Stress fiber assembly 0.2699682350285373 0.0987991478179885 0.921297745127048 1.0 1.0 24 P63167,O14786,P42345,Q7Z460,P07737,Q96AC1 6 +Udp n acetylglucosamine biosynthetic process 0.3566456745110993 0.0983330781910606 0.921667812854498 1.0 1.0 4 Q06210,Q16222,O95394 3 +Positive regulation of fat cell differentiation 0.3118707398445209 0.0977077682748936 0.9221643468851544 1.0 1.0 6 Q86X55 1 +Negative regulation of transcription regulatory region dna binding 0.4816164292812342 0.0975643220067734 0.9222782562144352 1.0 1.0 2 Q96ST3 1 +Motor neuron axon guidance 0.3185106747314083 0.0973476185479089 0.9224503414108712 1.0 1.0 5 O14786 1 +Mononuclear cell migration 0.2731609068919928 0.0963347788413833 0.9232546900061722 1.0 1.0 23 P04062,P05067,Q4KMQ2 3 +Macromolecule deacylation 0.2819886499406862 0.0958827309586726 0.9236137100796687 1.0 1.0 35 Q9NUJ1 1 +Regulation of b cell proliferation 0.3542426125040463 0.0952840237650891 0.924089232101894 1.0 1.0 4 Q13315 1 +Sodium ion export across plasma membrane 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 1.0 3 P05026 1 +Negative regulation of cell killing 0.4789665452136585 0.0951496629877448 0.924195951620702 1.0 1.0 2 P08238 1 +Neuron differentiation 0.3874712474574803 0.0950252583426913 0.9242947644406996 1.0 1.0 211 P00374,Q9BVA1,Q14108,O75503,Q15334,Q9Y4G8,Q13641,Q9HCE1,Q09472,Q12955,Q9NR77,P05067,Q9NQC3,Q9UQB8,P43034,P83731,Q96G23,P35613,Q9BW83,P50897,Q99873,P54802,P09429,O14949,Q13509,Q15648,P04062,Q9Y6M7,Q9NZJ7,P42892,Q96SZ6,P10586,Q96TA1,P50542,Q9H4M9,Q16880,Q16739,O43251 38 +Regulation of ire1 mediated unfolded protein response 0.3167281637137689 0.094584245121685 0.9246450642982148 1.0 1.0 5 Q92905,P57088 2 +Microtubule organizing center localization 0.2901932339364169 0.093881969603713 0.9252029167424164 1.0 1.0 12 P33176,P43034,Q13257 3 +Nadph regeneration 0.3050116163292481 0.0938772202768527 0.9252066894949597 1.0 1.0 8 P52209,P04637,P18669,P11413,P29401,O95336,Q13423 7 +Biological process involved in intraspecies interaction between organisms 0.3528969216768729 0.0936103443895227 0.9254186920665872 1.0 1.0 4 Q15334 1 +Retrograde transport endosome to golgi 0.2801854137474125 0.0932816951259629 0.92567977384291 1.0 1.0 33 P40616,O60749,Q92538,P14373,Q9UBQ0,O75503,P49257,Q9UNH7,O15260 9 +Positive regulation of mitotic nuclear division 0.2897593235062552 0.0931000716254556 0.9258240605355594 1.0 1.0 10 P30260,Q13042,Q8WWQ0 3 +Protein localization to microtubule end 0.4756541901291953 0.092232869229562 0.9265130234693066 1.0 1.0 2 Q15555 1 +Serine phosphorylation of stat protein 0.4743292480954114 0.0910973314086986 0.9274152530551508 1.0 1.0 2 Q00535 1 +Skeletal muscle organ development 0.275115526915471 0.0904426872101691 0.927935436179631 1.0 1.0 22 P60660,Q96TA1,Q09472 3 +Protein localization to cell periphery 0.2723059744000394 0.0903812822352006 0.92798423042295 1.0 1.0 75 P33176,P35613,Q15436,Q12955,O75915,Q13356,Q15334,Q9Y4G8,Q13641,Q9H4M9 10 +Modulation by host of symbiont catalytic activity 0.4730043060616192 0.0899794160786295 0.9283035720568288 1.0 1.0 2 Q9H1E3 1 +Mitochondrial fragmentation involved in apoptotic process 0.3136604774535788 0.0899502314880492 0.9283267639471556 1.0 1.0 5 Q9Y3D6,Q9NT62,Q8N163,O00429 4 +Regulation of cellular protein catabolic process 0.2732906649792665 0.0899335307777032 0.9283400353974098 1.0 1.0 76 P62191,P78559,P07900,Q06787,Q93009,Q96HY6,P62829,O00487,O15372,Q6ZXV5,O94966,P46379,O75150,Q96KB5,Q9UII2,P35241,Q04323,P63244,O00560,Q86UE8,P04062,Q9UL46 22 +Dendritic spine development 0.2747974625660151 0.0890537463607359 0.929039196335658 1.0 1.0 22 P43034,Q15334,Q9UQB8 3 +Negative regulation of dna biosynthetic process 0.2878716816540117 0.0885111751915919 0.9294704026817152 1.0 1.0 13 Q96TA1,Q15554 2 +Regulation of phosphatase activity 0.2869665397245121 0.0884046470464625 0.929555067950654 1.0 1.0 14 Q8IV63,Q8NFC6,P42858 3 +Regulation of apoptotic signaling pathway 0.2823125437539386 0.0882799649543414 0.92965416242683 1.0 1.0 85 Q9H300,O14786,Q86WB0,P45880,Q15233,P16989,Q96K76,P09601,Q8IWB1,Q8WUK0,P48507,P31689,P63241,P26583,P42858 15 +5 phosphoribose 1 diphosphate metabolic process 0.4615639496355142 0.0877615108824582 0.9300662295498452 1.0 1.0 3 Q14558,O60256 2 +Striated muscle cell proliferation 0.3116328485720534 0.0869714408074555 0.9306942130013768 1.0 1.0 5 Q12948,P06493 2 +Cardiac muscle cell proliferation 0.3116328485720534 0.0869714408074555 0.9306942130013768 1.0 1.0 5 Q12948,P06493 2 +Regulation of protein targeting 0.2742744418780998 0.0867777350981332 0.9308481856674828 1.0 1.0 22 O14737,Q12955,P55786,P49257,Q9H300,Q9UBE0 6 +Citrulline metabolic process 0.3470334769638662 0.086597901453219 0.9309911340331404 1.0 1.0 4 P27708,Q05682,P23634 3 +Citrulline biosynthetic process 0.3470334769638662 0.086597901453219 0.9309911340331404 1.0 1.0 4 P27708,Q05682,P23634 3 +Establishment of tissue polarity 0.2870153249437276 0.0860422502849344 0.9314328308707648 1.0 1.0 10 P43034,Q13308,Q8TAA9,P63000 4 +Cell activation 0.3064569028473779 0.0859307503052975 0.931521466704162 1.0 1.0 110 Q96J02,P24390,P02786,P09601,Q13315,Q00534,Q09472,O96005,Q9BY67,P05067,P46379,Q9UQ84,P49366,P42345,P52701,P09429,P04062,P78318,Q9NQT5,Q9BWH2,P48507 21 +Cellular response to sterol depletion 0.3453762015246833 0.0846976496348776 0.9325017645743624 1.0 1.0 4 O75477,P05198,Q9BY44 3 +Positive regulation of potassium ion transmembrane transporter activity 0.4575878064943612 0.0843390881417503 0.9327868352513552 1.0 1.0 3 P50570,P05026 2 +Cell chemotaxis 0.2791839691033508 0.0840457219995628 0.9330200794398752 1.0 1.0 34 Q13641,P35613,Q4KMQ2 3 +Negative regulation of intracellular transport 0.2830704730443457 0.0829182569078202 0.9339165371176192 1.0 1.0 17 Q9GZP9 1 +Dendrite extension 0.343536627263276 0.0826301087821376 0.934145659787038 1.0 1.0 4 Q9Y263 1 +Mitochondrial fusion 0.2856873776885181 0.081947852273996 0.9346881817605204 1.0 1.0 13 Q9Y6C9,Q9NX63,Q9H300 3 +Fatty acid derivative catabolic process 0.34257064533223 0.0815619024918477 0.9349950977235768 1.0 1.0 4 O00154 1 +Response to growth factor 0.2903873663451602 0.0805804205518901 0.9357756376971328 1.0 1.0 94 Q9UPN9,Q9Y4G8,Q92896,Q96AC1,Q9UNH7,O14737,O14786,Q09472,P46821,P05067,Q9UQB8,Q53EL6,Q12948,Q6IBS0,O00560,Q9Y4E8,Q15648,Q9Y3F4,Q96TA1,Q15286,Q9H4M9,P48507 22 +Bile acid biosynthetic process 0.3020238992389675 0.0804774685844873 0.9358575155661708 1.0 1.0 6 P22059 1 +L aspartate transmembrane transport 0.3410672853828211 0.0799232625964828 0.9362982881336704 1.0 1.0 4 Q9H936,Q9UJS0,O75746 3 +Positive regulation of toll like receptor 3 signaling pathway 0.4594236502153125 0.0795050000619114 0.9366309547303469 1.0 1.0 2 O75955 1 +Regulation of synaptic transmission dopaminergic 0.4594236502153125 0.0795050000619114 0.9366309547303469 1.0 1.0 2 O75955 1 +Cell adhesion molecule production 0.4594236502153125 0.0795050000619114 0.9366309547303469 1.0 1.0 2 O75955 1 +Positive regulation of heterotypic cell cell adhesion 0.4594236502153125 0.0795050000619114 0.9366309547303469 1.0 1.0 2 O75955 1 +Positive regulation of cell adhesion molecule production 0.4594236502153125 0.0795050000619114 0.9366309547303469 1.0 1.0 2 O75955 1 +Secretory granule organization 0.3406553533773314 0.0794793036772266 0.936651392802724 1.0 1.0 4 P43034 1 +Negative regulation of protein modification by small protein conjugation or removal 0.2773678845818064 0.0784278533967986 0.9374877179565052 1.0 1.0 33 Q9Y263,Q96FW1,O43684,O60678,P62841,P31689,Q13257,Q6DKJ4 8 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.4577674726730867 0.0783461373917351 0.9375527178914888 1.0 1.0 2 P23396 1 +Pentose phosphate shunt 0.3049104180491087 0.0776652749615226 0.9380943172067812 1.0 1.0 7 P52209,P04637,P18669,P11413,P29401,O95336 6 +Primary mirna processing 0.3384156446801392 0.0771031846361134 0.938541459571454 1.0 1.0 4 P22626,Q6ZN17,O00571 3 +Nuclear migration 0.2841645126897608 0.0767364141366516 0.9388332356414232 1.0 1.0 12 P43034,O94901,Q15154 3 +Positive regulation of membrane potential 0.3042408178499489 0.0766730100460064 0.9388836761816506 1.0 1.0 5 Q12955 1 +Positive regulation of type i interferon mediated signaling pathway 0.4469847581179529 0.075908848077008 0.9394916174251052 1.0 1.0 3 P61086,Q9NZI8 2 +Nuclear transcribed mrna poly a tail shortening 0.3035832780358353 0.0752968049694626 0.939978563532899 1.0 1.0 7 P11940,Q9HBH5,P62487,A5YKK6,Q9NZN8,Q5PRF9 6 +Negative regulation of organ growth 0.4430086149768002 0.0730004706250117 0.941805743006956 1.0 1.0 3 Q13043,O94826 2 +Negative regulation of translational initiation 0.3019243530192481 0.072381881503354 0.9422980034354376 1.0 1.0 7 Q6PKG0,P40429,Q06787,P05198,P60228,Q9BWF3 6 +Nadh oxidation 0.4416832339297488 0.0720607914346518 0.9425535289724944 1.0 1.0 3 Q16822,Q8N335 2 +Positive regulation of focal adhesion assembly 0.2941308654338245 0.0715412935364345 0.9429669612432704 1.0 1.0 8 Q96AC1,O14786 2 +Positive regulation of fatty acid transport 0.4455117588605641 0.0705220850497206 0.9437781229820056 1.0 1.0 2 P14174 1 +Amino acid import across plasma membrane 0.2992407845115409 0.0701994621330232 0.9440349024266717 1.0 1.0 5 O75915 1 +Cellular response to lipid 0.2890848099890649 0.0697693348095279 0.9443772549573708 1.0 1.0 94 Q86UE4,P11802,Q13315,Q8WTV0,Q9NZN8,O15173,P62826,Q09472,Q15120,O15118,Q53EL6,P26583,Q6IBS0,Q86X55,Q15185,Q9NUQ7,P09429,Q9H7B4,Q15648,O43251,Q9Y263 21 +Neutrophil activation involved in immune response 0.4377070907885954 0.0693294878777707 0.9447273542694532 1.0 1.0 3 P51809,O00186 2 +Neutrophil degranulation 0.4377070907885954 0.0693294878777707 0.9447273542694532 1.0 1.0 3 P51809,O00186 2 +Regulation of wnt signaling pathway 0.2786775463123673 0.0688822143752735 0.945083375761391 1.0 1.0 40 Q13641,Q96K76,P05067 3 +Signal transduction by p53 class mediator 0.2786429305610052 0.0686855704943745 0.945239904153931 1.0 1.0 40 P46379,Q09472,P42345,Q13315,P62841,P63241,O75844 7 +Tolerance induction 0.4361139855450701 0.0682715626342473 0.9455694610268236 1.0 1.0 3 P09429 1 +L glutamate import across plasma membrane 0.4333505015149893 0.066484990178277 0.946991707370804 1.0 1.0 3 O75915 1 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.4333499705855559 0.0664846528002389 0.9469919759652504 1.0 1.0 3 Q9UPY3 1 +Negative regulation of antigen receptor mediated signaling pathway 0.4382245776747356 0.0664646621621172 0.9470078909846128 1.0 1.0 2 P15311 1 +Negative regulation of t cell receptor signaling pathway 0.4382245776747356 0.0664646621621172 0.9470078909846128 1.0 1.0 2 P15311 1 +Response to virus 0.2692042867220425 0.0646418168005705 0.9484591893230834 1.0 1.0 75 Q96J02,Q92538,Q9NQT4,P07900,Q00534,Q9Y3Z3,Q9HCE1,P19474,P62244,P63241,O43657,O75844,Q7Z7L1,Q9H2U1,Q9BUJ2,O15111,Q9Y4E8,Q9NUD5,P14373,O14802,Q92890 21 +Bergmann glial cell differentiation 0.2932438379037604 0.0629481403354113 0.949807800382532 1.0 1.0 5 P08670 1 +Adaptive immune response 0.2768709737800688 0.0628206845286736 0.9499092945275948 1.0 1.0 37 Q9NZ08,Q9UQ84,Q96FW1,P42345,Q9BY67,P02786,Q9NQT5,P52701,P09429,P15151 10 +Positive regulation of defense response to virus by host 0.2895522388059655 0.0611419034296943 0.9512461974456936 1.0 1.0 6 O60828,Q7Z434,Q96ST3,P07900,O94826 5 +Positive regulation of sodium ion transmembrane transporter activity 0.2884602619755879 0.0608491258244386 0.9514793660258124 1.0 1.0 8 Q12955 1 +Thioester metabolic process 0.2768269066974228 0.0606353639016163 0.9516496090075404 1.0 1.0 38 Q9NZ01 1 +Regulation of protein folding 0.3178654292343334 0.0581675482836939 0.9536151696564704 1.0 1.0 4 Q9H2J4,O14737,Q9UL15 3 +Ire1 mediated unfolded protein response 0.2873890063347947 0.0580663713488502 0.9536957609538508 1.0 1.0 6 Q92905,P57088 2 +Negative regulation of cell size 0.4160147362873507 0.0566163272710335 0.9548508281252384 1.0 1.0 3 P42345 1 +Negative regulation of peptidyl serine phosphorylation 0.3155452436194847 0.056339778081822 0.955071130815072 1.0 1.0 4 P63244,Q13610,Q8N335 3 +Positive regulation of mitotic cell cycle spindle assembly checkpoint 0.4142593990315701 0.0557392025526096 0.9555495689107756 1.0 1.0 3 Q13257 1 +Respiratory burst 0.3142194232681403 0.0553221957191004 0.9558817796153144 1.0 1.0 4 P18669,P63000,P39019 3 +Nucleotide sugar metabolic process 0.2760818917667748 0.0545961291314827 0.9564602226666185 1.0 1.0 13 Q9Y223 1 +Regulation of lipophagy 0.4096918931861254 0.0535557790778512 0.9572890890992672 1.0 1.0 3 P42858 1 +Positive regulation of immune response 0.2583275915945555 0.0531280283474646 0.9576298995912058 1.0 1.0 66 Q9NR50,P46379,Q15233,Q09472,Q15648,P02786,Q9BY67,Q9NQT5,Q8WXF1,P07900,P43246,Q9NUD5,P61088,Q07666,P09429,P26583,P49770,P15151 18 +Negative regulation of viral entry into host cell 0.4078860172299475 0.0527310470199867 0.9579462014852274 1.0 1.0 3 O60493,Q14258 2 +Negative regulation of viral life cycle 0.4078860172299475 0.0527310470199867 0.9579462014852274 1.0 1.0 3 O60493,Q14258 2 +Cell proliferation in forebrain 0.310410759202436 0.0525057856031226 0.9581256854510212 1.0 1.0 4 Q15058 1 +Regulation of defense response to virus by host 0.2896483078964871 0.0523772185106756 0.9582281261904416 1.0 1.0 7 O60828,Q7Z434,Q96ST3,P07900,Q08211,O94826 6 +Regulation of stem cell proliferation 0.2831926324433531 0.0523305984519713 0.9582652726726164 1.0 1.0 6 Q96AC1 1 +Nuclear ncrna surveillance 0.2831860295583405 0.0523218111312774 0.9582722743481598 1.0 1.0 6 Q15024 1 +Dna replication synthesis of rna primer 0.4066792332357355 0.0521918287797709 0.958375843750566 1.0 1.0 3 P09884 1 +Positive regulation of endothelial cell chemotaxis 0.4021199072540687 0.0519190831726558 0.9585931686090292 1.0 1.0 2 Q9NWH9 1 +Regulation of endothelial cell chemotaxis 0.4021199072540687 0.0519190831726558 0.9585931686090292 1.0 1.0 2 Q9NWH9 1 +N terminal peptidyl methionine acetylation 0.4017886717456238 0.0518224501761269 0.9586701669303525 1.0 1.0 2 Q14CX7 1 +Regulation of canonical wnt signaling pathway 0.2701279904760567 0.051676359570496 0.9587865743949112 1.0 1.0 31 Q13641 1 +Negative regulation of dna replication 0.276343264649575 0.0515597911283529 0.9588794587309536 1.0 1.0 9 Q9UNS1 1 +Positive regulation of sodium ion transmembrane transport 0.2761919342825893 0.0512652970271476 0.9591141206866038 1.0 1.0 9 Q12955 1 +Protein deubiquitination involved in ubiquitin dependent protein catabolic process 0.398145081152718 0.0507971781680138 0.9594871394717968 1.0 1.0 2 Q93008 1 +Regulation of macrophage migration 0.3078460248394679 0.0506968390659623 0.9595670954721234 1.0 1.0 4 P27361,P14174 2 +Regulation of macrophage chemotaxis 0.3078460248394679 0.0506968390659623 0.9595670954721234 1.0 1.0 4 P27361,P14174 2 +Positive regulation of protein kinase activity 0.2733999871091124 0.0504118586392017 0.959794186575349 1.0 1.0 47 Q9Y5X1 1 +Membrane organization 0.3751556037665938 0.0501295137307053 0.9600191807421314 1.0 1.0 200 P08183,O00443,P45880,Q9NX63,Q86XL3,Q9Y5X1,Q15334,Q8WUX9,Q9NS69,Q7Z3C6,Q8N4V1,Q12955,O15118,Q9NQC3,Q9UQB8,P43034,Q9Y5P4,O75844,P46379,Q15629,P50897,Q13505,Q9Y512,Q4KMQ2,Q96CP7,Q9NZJ7,Q96GC9,O43760,P50542,Q15392,Q16739 31 +Aldehyde biosynthetic process 0.4016892769466998 0.0500611646397224 0.960073647040906 1.0 1.0 3 O00764 1 +Positive regulation of t cell receptor signaling pathway 0.3948327260682456 0.0499232600018266 0.9601835416109972 1.0 1.0 2 P23396 1 +Positive regulation of antigen receptor mediated signaling pathway 0.3948327260682456 0.0499232600018266 0.9601835416109972 1.0 1.0 2 P23396 1 +B cell lineage commitment 0.3945014905597998 0.0498388196655767 0.9602508314869064 1.0 1.0 2 P78527 1 +Glycolytic fermentation 0.394501490559798 0.0498388196655761 0.9602508314869068 1.0 1.0 2 O75746 1 +Fermentation 0.394501490559798 0.0498388196655761 0.9602508314869068 1.0 1.0 2 O75746 1 +T cell proliferation involved in immune response 0.394501490559797 0.0498388196655758 0.9602508314869072 1.0 1.0 2 P62753 1 +Regulation of transcription from rna polymerase ii promoter in response to hypoxia 0.3945014905597961 0.0498388196655758 0.9602508314869072 1.0 1.0 2 Q8IXJ6 1 +Cellular response to radiation 0.2752662093822597 0.0497757937609986 0.960301056546084 1.0 1.0 40 P29692,Q09472,Q86UE8,Q96KB5,P28340,Q96K76,Q9H2U1,P61254,O14757,Q13315,P12004,O75844 12 +Adenylate cyclase inhibiting dopamine receptor signaling pathway 0.3938390195429085 0.0496715187596841 0.9603841531703592 1.0 1.0 2 O14744 1 +Skeletal system development 0.2716536813302787 0.0493937183814523 0.9606055340589544 1.0 1.0 49 Q15648,Q09472,P16435,O95470,P43034,O43252,O75844,Q7Z3C6 8 +Positive regulation of intracellular signal transduction 0.3193518709401361 0.0486003997230325 0.9612377514102706 1.0 1.0 129 Q86UE4,P02786,P09601,P07900,Q13315,P63000,Q9Y4G8,P61088,Q96AC1,Q13641,Q13257,P18615,P29692,O14786,Q09472,P19474,P05067,Q9NQC3,Q53EL6,P29372,O43657,P63241,Q99873,Q9Y4R8,Q8TB61,Q9H2U1,O15111,P62841,P09429,O00560,Q9Y4E8,Q9NUD5,O75915,P61254,P14373 35 +Protein stabilization 0.2608349668127311 0.047708392416248 0.9619486455399826 1.0 1.0 69 P07900,Q9UBV2,Q93009,P35080,P62829,Q09472,O95785,P07737,Q9NQC3,Q32P28,O94966,P46379,Q14149,Q9Y4R8,Q969V3,Q9UHD1,P78371,Q15185,O75718,Q99832,P05026 21 +Regulation of cell matrix adhesion 0.2620702176783505 0.0477018072049212 0.9619538938030938 1.0 1.0 23 P63167,O14786,Q7Z460,P63000,Q00534,Q96AC1,Q9P258 7 +Positive regulation of rna polymerase ii transcription preinitiation complex assembly 0.3946322067594391 0.0473091892706372 0.962266804305976 1.0 1.0 3 Q86VP6,P62333 2 +Negative regulation of helicase activity 0.3946322067594365 0.0473091892706361 0.9622668043059768 1.0 1.0 3 P33993,P49736 2 +Dna damage response signal transduction resulting in transcription 0.3946322067594365 0.0473091892706361 0.9622668043059768 1.0 1.0 3 O96017,P61254 2 +Cellular response to epinephrine stimulus 0.3943008614976743 0.0471872131881178 0.9623640185681674 1.0 1.0 3 P23634,Q8IXJ6 2 +Response to epinephrine 0.3943008614976743 0.0471872131881178 0.9623640185681674 1.0 1.0 3 P23634,Q8IXJ6 2 +Positive regulation of fatty acid metabolic process 0.3929754804506248 0.0467056155127731 0.962747854700136 1.0 1.0 3 Q92604,P50416 2 +Golgi to endosome transport 0.2776772699466554 0.046634677913942 0.9628043931082448 1.0 1.0 5 Q7Z3U7,Q92538 2 +Endocrine pancreas development 0.3010276075175269 0.046219228934182 0.9631355163784344 1.0 1.0 4 Q00534 1 +Regulation of organelle transport along microtubule 0.3749585955614599 0.0457132944472051 0.9635387674509308 1.0 1.0 2 P27695 1 +Regulation of protein catabolic process 0.3015486271192371 0.0453626776078153 0.9638182293009744 1.0 1.0 110 P46379,Q86UE8,P04062,Q9Y5X1,Q16850,P10619,Q6ZXV5 7 +Negative regulation of intracellular estrogen receptor signaling pathway 0.275970367107313 0.0450572724018515 0.9640616584939354 1.0 1.0 5 Q9NZN8 1 +Succinate metabolic process 0.2976466688763609 0.0441715710294977 0.9647676429594232 1.0 1.0 4 P21912,Q9P2R7,P31040 3 +Regulation of mitochondrial mrna stability 0.3848528435072437 0.043967390786246 0.964930397102124 1.0 1.0 3 Q969Z0 1 +Negative regulation of protein kinase b signaling 0.3607154686982564 0.0436070154687047 0.9652176594836546 1.0 1.0 2 P63244 1 +Release of cytochrome c from mitochondria 0.2717188523134479 0.0428836559526648 0.9657942774250508 1.0 1.0 14 Q96A26,O75223,Q9H300 3 +Ribonucleoprotein complex disassembly 0.2732369335078479 0.0426146952026594 0.9660086810543028 1.0 1.0 5 P33176 1 +Cdp diacylglycerol metabolic process 0.2732095490716157 0.0425907393688923 0.9660277777062098 1.0 1.0 5 Q99943,O96017,Q86UL3,Q96BW9 4 +Establishment or maintenance of monopolar cell polarity 0.2698628151779181 0.0424729804727159 0.9661216507666386 1.0 1.0 11 Q8NI35,Q9P1Y5,Q92538,P46821 4 +Peptidyl lysine acetylation 0.2738571922332942 0.0416070619708162 0.9668119434800356 1.0 1.0 41 P46379,O14929,P16435,P49711,O75844 5 +Convergent extension 0.3401788671745714 0.0415652570488006 0.9668452701516947 1.0 1.0 2 Q13308 1 +Mammalian oogenesis stage 0.337528983107001 0.0413697843264965 0.9670011007813282 1.0 1.0 2 P62753 1 +Regulation of integrin activation 0.3748473493512998 0.0410650616961862 0.967244027823319 1.0 1.0 3 Q96AC1 1 +Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.3747514910536721 0.0410396026502967 0.967264324093168 1.0 1.0 3 Q99729,A2RRP1 2 +Positive regulation of gastrulation 0.3309042729380695 0.0409367306573969 0.9673463351485544 1.0 1.0 2 P63244 1 +Establishment of epithelial cell apical basal polarity 0.2734839772266514 0.040202361794992 0.9679317947138946 1.0 1.0 6 Q9P1Y5,Q13308,P26038 3 +Regulation of lipopolysaccharide mediated signaling pathway 0.314011262007299 0.0401322103838915 0.9679877223064228 1.0 1.0 2 P14174 1 +Regulation of dopamine receptor signaling pathway 0.3133487909904056 0.040107969056477 0.968007048527088 1.0 1.0 2 O14744 1 +Positive regulation of dopamine receptor signaling pathway 0.3133487909904056 0.040107969056477 0.968007048527088 1.0 1.0 2 O14744 1 +Mitotic nuclear membrane disassembly 0.3100364359059406 0.0399937533293353 0.9680981064313372 1.0 1.0 2 P53350 1 +Glutamate homeostasis 0.2633322292149853 0.0392133726251453 0.9687202720242314 1.0 1.0 2 Q9UPY5 1 +Enteroendocrine cell differentiation 0.3656163436349917 0.0388028482297854 0.9690475739873918 1.0 1.0 3 Q00534 1 +Positive regulation of rna binding 0.2719734660033128 0.0384555963862868 0.9693244342258078 1.0 1.0 6 Q09161,Q06787,O15371,P60228,P50750 5 +Negative regulation of erad pathway 0.3621603711066897 0.038049430820744 0.969648270443318 1.0 1.0 3 O43765,Q04323 2 +Copii coated vesicle cargo loading 0.2690958077032976 0.0380219342892897 0.969670193637217 1.0 1.0 9 Q9NR31,Q15436 2 +Negative regulation of hydrolase activity 0.2654146479396753 0.037764376953472 0.9698755471728115 1.0 1.0 53 Q8NFC6,Q96K76,Q4VCS5,Q8NDZ2,P30086,P16435,P05067,Q15392,O00170,Q9P258 10 +Dephosphorylation 0.2761243003349028 0.0376033821147224 0.9700039112931902 1.0 1.0 85 P63167,Q96T60,Q9Y217,Q8NFC6,P04062,Q13362,Q86XL3,Q9NPH0,P10586,Q8IV63,Q8WUK0,P11117,Q6PIU2,P42858 14 +Protein localization to membrane raft 0.2843884653629407 0.0371715067407951 0.9703482572324488 1.0 1.0 4 O75955,P41440,P05026 3 +Nuclear transcribed mrna catabolic process exonucleolytic 3 5 0.2655821299085188 0.0371606189415815 0.970356938441524 1.0 1.0 10 Q9NQT5,Q9NQT4,Q15024 3 +Proton transporting two sector atpase complex assembly 0.3571901921802473 0.0370486974061656 0.9704461774553002 1.0 1.0 3 Q9BUB7,Q92544 2 +Mitotic intra s dna damage checkpoint signaling 0.2837255551872693 0.0368622279861116 0.97059485696547 1.0 1.0 4 P43246,O96017,P49959 3 +Posttranslational protein targeting to membrane translocation 0.3555334658714327 0.0367358659388148 0.9706956110498404 1.0 1.0 3 P61619,Q9UGP8 2 +Negative regulation of cell junction assembly 0.2782387881388968 0.0362131148290994 0.9711124287277322 1.0 1.0 7 Q9P258 1 +Epigenetic maintenance of chromatin in transcription competent conformation 0.2695644444187307 0.0357461710459229 0.9714847548871328 1.0 1.0 6 Q09472 1 +Lens fiber cell differentiation 0.3433943504151276 0.0347338308436802 0.9722919840828044 1.0 1.0 3 P08670 1 +Positive regulation of mitochondrial membrane potential 0.3426110006626863 0.0346209763990169 0.972381974777592 1.0 1.0 3 Q8IWA4,Q9UJZ1 2 +Negative regulation of smoothened signaling pathway 0.3426110006626859 0.0346209763990169 0.972381974777592 1.0 1.0 3 P63244,P17612 2 +Regulation of ubiquitin specific protease activity 0.3426110006626852 0.0346209763990166 0.9723819747775924 1.0 1.0 3 Q99497,Q04323 2 +Uv damage excision repair 0.3412856196156356 0.0344342299615135 0.9725308880862832 1.0 1.0 3 P09884,Q13620 2 +Regulation of dna demethylation 0.3402915838303455 0.0342975770705596 0.9726398569521272 1.0 1.0 3 Q93008,Q93009 2 +Embryonic placenta morphogenesis 0.3402915838303464 0.0342975770705596 0.9726398569521272 1.0 1.0 3 Q9BYW2,P62993 2 +Positive regulation of actin filament depolymerization 0.3347594248749507 0.0335882660812616 0.9732054793006228 1.0 1.0 3 Q9Y281 1 +Insulin like growth factor receptor signaling pathway 0.2757706330792122 0.0334309373432269 0.9733309390128226 1.0 1.0 4 Q6Y7W6,P11717,Q8WWQ0 3 +Chromatin remodeling at centromere 0.3326706428098035 0.0333420156634484 0.9734018487172078 1.0 1.0 3 Q9NRZ9,Q7Z7K6 2 +Establishment of planar polarity of embryonic epithelium 0.3303581284138772 0.0330824468003878 0.9736088405120528 1.0 1.0 3 P43034 1 +Late endosome to golgi transport 0.326375082836311 0.0326660669132677 0.9739408841219848 1.0 1.0 3 O60493,Q9UMY4 2 +Positive regulation of vascular associated smooth muscle cell proliferation 0.2737819025521991 0.0326507283156821 0.9739531160273456 1.0 1.0 4 P08754,P26358,O95140 3 +Regulation of cyclase activity 0.2737819025521987 0.0326507283156818 0.9739531160273458 1.0 1.0 4 P08754,Q01518,P27361 3 +Rna splicing via endonucleolytic cleavage and ligation 0.3220675944333951 0.0322569172224737 0.9742671663860388 1.0 1.0 3 Q92499,Q9Y3I0 2 +Interleukin 1 mediated signaling pathway 0.3190854870775299 0.0319970975918455 0.9744743655000077 1.0 1.0 3 P27361,Q9NZI8 2 +Histone serine phosphorylation 0.3101391650099345 0.0313219125449678 0.975012815296096 1.0 1.0 3 Q13043,P54646 2 +Histone threonine phosphorylation 0.3101391650099351 0.0313219125449678 0.975012815296096 1.0 1.0 3 Q9Y4B6,O14757 2 +Specification of symmetry 0.2700863701273436 0.0312790232159038 0.9750470192703256 1.0 1.0 4 Q8NCM8 1 +Deadenylation dependent decapping of nuclear transcribed mrna 0.3071570576540703 0.0311284819094308 0.9751670753924078 1.0 1.0 3 Q8IU60,Q86TB9 2 +Negative regulation of mitotic cell cycle phase transition 0.2712459511508089 0.030980421041405 0.9752851539230024 1.0 1.0 38 Q7Z7L1,Q6NUQ1,Q96K76,P49454,P61254,O14757,Q68E01,Q9NWV8,O43684,Q13315,P06493,P53350,P14635,Q969U7,Q9Y619,Q13257,P15927 17 +Negative regulation of histone acetylation 0.2977617216467746 0.0306088907254328 0.9755814516997756 1.0 1.0 3 Q13363 1 +Regulation of deoxyribonuclease activity 0.2574946031162882 0.0304518179425795 0.9757067192532992 1.0 1.0 5 P09429,P12004 2 +Apical protein localization 0.2849569251159647 0.0300852936066244 0.97599902942464 1.0 1.0 3 P35241,P18085 2 +Regulation of stress granule assembly 0.2770046388336585 0.0298456854590953 0.976190123251983 1.0 1.0 3 Q9UN86,P54646 2 +Amino acid homeostasis 0.2634194831013861 0.0295514604810067 0.9764247773126796 1.0 1.0 3 P29144,Q9UPY5 2 +Mrna pseudouridine synthesis 0.2620941020543345 0.0295291288331341 0.9764425876171444 1.0 1.0 3 Q96PZ0,Q9Y606 2 +Pyrimidine nucleoside triphosphate metabolic process 0.2666654599122361 0.0292411559364463 0.9766722575646792 1.0 1.0 14 P17812,O75414,Q9NRF8 3 +Anion homeostasis 0.2635067948292953 0.0290756802941054 0.9768042319096402 1.0 1.0 4 P55011,Q9UPY5,P12277 3 +Positive regulation of nuclear division 0.2628071140002044 0.0272055829223617 0.9782957628275132 1.0 1.0 11 P30260,Q13042,Q8WWQ0 3 +Microtubule anchoring 0.261934154479659 0.0257704924149548 0.979440397670958 1.0 1.0 9 Q7Z460,Q9P1Y5 2 +Regulation of golgi to plasma membrane protein transport 0.2485913158766897 0.0250932210382592 0.9799806073091092 1.0 1.0 4 P63244,O75608,P41240 3 +Hematopoietic stem cell homeostasis 0.2463535454431225 0.023648620363767 0.9811328895385548 1.0 1.0 5 Q9NVX2 1 +Focal adhesion assembly 0.2608178563390185 0.0236283361614294 0.9811490694693044 1.0 1.0 21 P63167,O14786,Q7Z460,P63000,Q96AC1,Q9P258 6 +Animal organ morphogenesis 0.2783379054846029 0.0231908980197067 0.9814979989845484 1.0 1.0 89 P35613,P10253,Q15648,Q09472,P43034,P04062,Q12948,P53701,P54802,P16435,O95470,Q9NQC3,Q8TAA9,Q53EL6,Q9Y5P4,O75844,Q7Z3C6 17 +Rna secondary structure unwinding 0.2363274776267769 0.0227089824280529 0.9818824107428992 1.0 1.0 4 Q08211,Q9H2U1,O00571 3 +Positive regulation of chromosome separation 0.2590495900626073 0.0211478312239158 0.9831277296144124 1.0 1.0 9 P30260,Q13042 2 +Positive regulation of cell matrix adhesion 0.2597514328345077 0.0209820871776065 0.9832599448924936 1.0 1.0 11 Q96AC1,O14786,Q00534 3 +Positive regulation of proteolysis 0.2699103648076513 0.0206839405181373 0.9834977798905432 1.0 1.0 81 P46379,P09429,P04062,Q9NZJ7,O75915,Q9Y5X1,P05067,Q6ZXV5,Q96A26 9 +Sensory organ development 0.259993108026016 0.020168519773697 0.9839089403569306 1.0 1.0 55 Q15648,Q9Y6M7,P42892,Q15042,P54802,P43034,P83731,Q12948 8 +Regulation of neurotransmitter levels 0.2591383723731476 0.0194788922889739 0.984459075362336 1.0 1.0 28 Q15042,P50897 2 +Positive regulation of stem cell proliferation 0.2074908849850806 0.0193976635187812 0.9845238743007608 1.0 1.0 4 Q96AC1,Q00839,O60341 3 +Regulation of leukocyte proliferation 0.2631197482898963 0.0189183149544822 0.984906268934484 1.0 1.0 18 Q96J02,Q13315,P49366,P09429 4 +Carbohydrate derivative biosynthetic process 0.3377842198224947 0.0182289159823363 0.9854562348481232 1.0 1.0 155 Q9Y5P6,Q9NZ01,P00846,O75964,Q13126,Q86YN1,Q8NBX0,O15118,P00403,Q6ZXV5,O43252,Q2TAA5,Q99805,O60502,P50897,Q8TB61,O75414,O00154,Q16880,P30085,Q9NRF8,Q8NCH0,Q16739,Q9Y223,Q7LGA3 25 +Positive regulation of telomere maintenance 0.2570665748140223 0.0174442698087235 0.9860821923194456 1.0 1.0 27 Q96T60,P22626,P78371,Q13315,Q15554 5 +Primary alcohol metabolic process 0.262790027490265 0.0169617616647276 0.9864671211514128 1.0 1.0 17 Q9BTZ2,P51648,Q9BY49,Q9HBH5,P14550,Q6NUM9 6 +Regulation of mitochondrial gene expression 0.2596259618848688 0.016702129449064 0.9866742483440604 1.0 1.0 12 Q567V2,Q96SZ6 2 +Glandular epithelial cell differentiation 0.2280157522560011 0.0152429256901801 0.987838375884538 1.0 1.0 5 Q00534 1 +Cardiac septum morphogenesis 0.2264588859416451 0.0146702256589209 0.9882952732845682 1.0 1.0 5 O96028,O94813,O14786,P04637 4 +Regulation of histone phosphorylation 0.2587543427486116 0.013749114848307 0.9890301391593024 1.0 1.0 7 Q13315,P27361,Q06787 3 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.2586898395721902 0.0110765197069941 0.9911623966519418 1.0 1.0 29 Q9NQT4,Q8IU60,O60506,Q86TB9,Q9NZN8,Q5PRF9,Q06265,O75534,Q15024,Q9H074,Q9NZI8,Q9NPI6,Q13868,P67809,Q9Y2L1,Q08211,Q96B26,O95453,Q6L8Q7,O15514,Q9H2U1,Q14103,P11940,Q9HBH5,P62487,A5YKK6,Q9NQT5,Q00839 28 +Cellular component maintenance 0.2583005064040196 0.010586233314749 0.991553565644373 1.0 1.0 13 P56545,Q15334,Q9P1Y5,Q96AC1 4 +Regulation of signal transduction by p53 class mediator 0.261122182584556 0.0098964261202827 0.9921039232810158 1.0 1.0 31 Q09472,P42345,P61254,O14757,Q13315,O43324,P62841,Q93009,O14744,P63241,O75844 11 +Positive regulation of ubiquitin protein transferase activity 0.2499441118761429 0.0084720408623451 0.993240370260148 1.0 1.0 10 Q96GG9 1 +Striated muscle cell development 0.2495379475385162 0.007803797843844 0.9937735333827034 1.0 1.0 10 Q16527 1 +U4 snrna 3 end processing 0.2520593502305116 0.0072504552585374 0.9942150243756273 1.0 1.0 8 Q9NQT4,Q15024 2 +Stress granule assembly 0.2584752133875821 0.0055308045281503 0.9955870789565762 1.0 1.0 16 P62266,P54646 2 +Positive regulation of growth 0.2645200588865845 0.0051725122115601 0.9958729507689597 1.0 1.0 49 Q9BSK2,O14786,Q9UGN5,P16989,Q96K76,Q6PJG6,P46821,Q9GZP9,Q6IBS0,P50542,Q7Z4V5,P43034,O00560,O43598,Q9Y263 15 +Cellular defense response 0.1813648544543875 0.0050089005573125 0.996003492290184 1.0 1.0 5 Q08380 1 +Ires dependent viral translational initiation 0.2536658450874393 0.0045031546268317 0.9964070145916806 1.0 1.0 12 P41214,Q15366,Q9ULC4,P26599,O00303 5 +Protein heterotetramerization 0.2481751824817566 0.0040749709940105 0.9967486525564766 1.0 1.0 7 Q9NSD9,O43809,Q9Y285,Q8N684,Q16630,P31350 6 +Response to heat 0.263944998027848 0.0039706800969187 0.9968318639797475 1.0 1.0 35 Q9NR50,Q09472,P42345,O15514,P09601,P07900,Q9H2U1,Q13315,P31689,P49770 10 +Pyrimidine ribonucleoside monophosphate metabolic process 0.2303788727335614 0.0036699565255217 0.9970718049225752 1.0 1.0 6 P30085 1 +Ump biosynthetic process 0.2303788727335614 0.0036699565255217 0.9970718049225752 1.0 1.0 6 P30085 1 +Regulation of secretion 0.2645852260252558 0.0033379810060534 0.9973366814368524 1.0 1.0 78 P09601,Q15042,Q8WUM4,Q06787,Q15334,Q16850,Q15019,P53985,P35080,Q9UNH7,P35580,O00330,Q7Z460,P17858,Q32P28,Q12904,P16615,O00560,P50416,P22059,P55809 21 +Actin filament bundle organization 0.2664581572146994 0.0030832717023027 0.9975399090098084 1.0 1.0 40 P63167,O14786,P42345,Q7Z460,Q8N5W9,P07737,P35611,Q9UQB8,Q96AC1 9 +Protein heterooligomerization 0.2482575506140094 0.0030750059028474 0.997546504132312 1.0 1.0 8 Q9NSD9,O43809,Q9Y285,Q8N684,P31153,Q16630,P31350 7 +Mirna metabolic process 0.2479561921957906 0.0027547544839224 0.997802026708426 1.0 1.0 8 Q9UPY3,Q92945 2 +Vesicle cargo loading 0.2527029827521816 0.0026190932544813 0.9979102683180844 1.0 1.0 12 P62820,Q15436,Q9NR31 3 +Rab protein signal transduction 0.2278606965174103 0.0022917305883056 0.9981714651466578 1.0 1.0 6 P31150,Q15286,Q9UL25,P51151,P20338 5 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4f39dc30672679950041dfa73849ea3bbf913142 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acidic amino acid transport", "Acrosome assembly", "Acrosome reaction", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone mineralization involved in bone maturation", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cocaine", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to progesterone stimulus", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide 1 phosphate transport", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Corticotropin secretion", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of light stimulus involved in sensory perception", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of stimulus involved in sensory perception", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Dipeptide transmembrane transport", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Double strand break repair via synthesis dependent strand annealing", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated inhibitory signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled glutamate receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Heparin biosynthetic process", "Heparin metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "Hexose phosphate transport", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 demethylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immature b cell differentiation", "Immune effector process", "Immune response", "Immune response inhibiting cell surface receptor signaling pathway", "Immune response inhibiting signal transduction", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of animal organ identity", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell proliferation", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotactic protein 1 production", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone mineralization", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of camp mediated signaling", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of g0 to g1 transition", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of hexokinase activity", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane depolarization", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotactic protein 1 production", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to microtubule", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smooth muscle contraction", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor 2 signaling pathway", "Negative regulation of toll like receptor 4 signaling pathway", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of torc1 signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron fate specification", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide import across plasma membrane", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otolith development", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet derived growth factor receptor alpha signaling pathway", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic dna fragmentation", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna catabolic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of enamel mineralization", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial cell proliferation involved in wound healing", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoblast proliferation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phospholipid translocation", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tooth mineralization", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride catabolic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Preassembly of gpi anchor in er membrane", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked deubiquitination", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of acrosome reaction", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adiponectin secretion", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen processing and presentation", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone mineralization involved in bone maturation", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte development", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of corticotropin secretion", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of enamel mineralization", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of ketone biosynthetic process", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of melanocyte differentiation", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non membrane spanning protein tyrosine kinase activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of ovarian follicle development", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigment cell differentiation", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor activity", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 2 signaling pathway", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tooth mineralization", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Relaxation of cardiac muscle", "Relaxation of muscle", "Relaxation of smooth muscle", "Relaxation of vascular associated smooth muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to staurosporine", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal complex assembly", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transcription by rna polymerase iii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somite development", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfation", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Tolerance induction to self antigen", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterine smooth muscle contraction", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf57", "C17orf75", "C19orf70", "C1QBP", "C20orf27", "C2CD5", "C2orf49", "C3orf58", "C5orf51", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC47", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COASY", "COG1", "COG3", "COG8", "COIL", "COL4A3BP", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM129B", "FAM162A", "FAM208A", "FAM210B", "FAM213A", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRIG2", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL20", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS27", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NEO1", "NES", "NFATC2IP", "NFS1", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TFAM", "TFB1M", "TFCP2", "TFIP11", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM14C", "TMEM167A", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPMT", "TPP1", "TPP2", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSR1", "TSR2", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTF2", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXN2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL4A", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBLCP1", "UBN2", "UBP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VMP1", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS36", "VPS37B", "VPS37C", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR62", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK2", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H13", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFYVE16", "ZFYVE26", "ZMPSTE24", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF148", "ZNF207", "ZNF281", "ZNF326", "ZNF512B", "ZNF598", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AASDHPPT", "ABCB1", "ABCC4", "ABCD3", "ABHD10", "ABHD12", "ABRAXAS2", "ACAD9", "ACADVL", "ACAT2", "ACOT7", "ACP2", "ACP6", "ACSL1", "ADD1", "ADD3", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AGAP3", "AGL", "AGPAT1", "AGPS", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AKR1A1", "ALDH3A2", "ALDH6A1", "ALG11", "AMOT", "ANAPC5", "ANK3", "ANKLE2", "ANO6", "ANXA1", "AP1M1", "AP2M1", "AP3B1", "AP3S1", "APEX1", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARL1", "ARL6IP5", "ARPC3", "ASAH1", "ASCC2", "ASNA1", "ASNS", "ATG3", "ATG9A", "ATM", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5L", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V1B2", "ATPIF1", "B4GALT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BCAT2", "BCL10", "BOD1L1", "BPHL", "BPNT1", "BRAT1", "BRD2", "BRD4", "BSG", "BUB3", "CAD", "CADM1", "CALD1", "CAMSAP3", "CAND1", "CAP1", "CAPZA1", "CAPZA2", "CARM1", "CASP7", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT7", "CDC123", "CDC16", "CDC27", "CDK1", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CENPF", "CENPV", "CERS2", "CFAP20", "CFL2", "CHCHD3", "CHEK1", "CHEK2", "CHKA", "CHMP7", "CHORDC1", "CHST14", "CHUK", "CKB", "CLASP1", "CLCN3", "CLN5", "CLPP", "CLPTM1", "CLUH", "CMPK1", "CNOT1", "CNOT11", "CNOT2", "COA3", "COL4A3BP", "COPE", "COPG1", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "CORO1B", "COTL1", "COX14", "COX2", "COX7A2", "COX7A2L", "CPNE1", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSK", "CSRP2", "CSTB", "CTBP1", "CTBP2", "CTCF", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4B", "CWC27", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DCAF1", "DCAKD", "DCP1A", "DCP2", "DCUN1D1", "DCUN1D5", "DDI2", "DDRGK1", "DDX1", "DDX20", "DDX3X", "DDX6", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS4", "DHRS7B", "DHX36", "DHX9", "DICER1", "DIS3", "DNAJA1", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOLPP1", "DPYSL5", "DRG2", "DUSP3", "DYNC2H1", "DYNLL1", "DYNLL2", "ECE1", 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0000000000000000000000000000000000000000..a87d4af923fcff93de1653346c76e35d6510c713 --- /dev/null +++ b/msigdb_gocc/df_merge.tsv @@ -0,0 +1,22 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Vacuolar lumen 23 61 3.495401281513196 0.0004733495163582 22.262135922330096 63.33980582524272 0.6562244405592584 0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 0.0013502122220401 0.0020388417604097 1.3871254672632278e-05 2.7811018737228935e-10 1.07468933074889e-09 +Azurophil granule 15 65 3.025550959606344 0.0024818057899649 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 0.0013502122220401 0.0020388417604097 0.0001147648467817 4.10774749009585e-06 3.985931601063975e-05 +Lysosomal lumen 18 34 2.7788865035357526 0.0054545579589631 18.075242718446603 34.54368932038835 0.7848519845050315 0.1014568164283454 6.206531846566726 3.2976210873168883 3.038689298289951 0.2012423645269794 0.0028935866222406 0.0039603320298963 0.0004780854780595 6.733235732363847e-10 3.1337055939385987e-10 +Membrane microdomain 8 63 2.364885906493634 0.01803562621418 14.75485436893204 63.49029126213592 0.5762129399877682 0.5023556315347317 6.545256989336744 6.436953608643344 1.167657055169838 0.3823949317010994 0.0480169472592386 0.0128770869665488 0.0108815331897538 0.0474007575213468 0.3492761819202067 +Clathrin coated vesicle 7 43 2.3229291123825773 0.0201829608885557 9.936893203883496 47.157766990291265 0.2628715125167937 0.534532305855711 4.553447222704333 4.879804116719352 1.1779559306555245 0.358217133589648 0.0145652477947894 0.0195546565017083 0.1126980972536071 0.0097493412203365 0.074771567861078 +Outer membrane 13 79 2.311464447137698 0.0208072147502966 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 0.0009294906726748 0.0015394329593435 0.0003409613770365 0.001546651585699 0.0073103743108197 +Azurophil granule membrane 4 20 2.297496265314477 0.0215904758721676 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 0.1770329207061845 0.1955113655682517 0.0720571885403784 0.0049696490954306 0.0234997369098134 +Magnesium dependent protein serine threonine phosphatase complex 0 9 2.272192818285893 0.0230748668569682 3.570388349514563 8.978155339805825 -0.0595363192103511 0.4977467020976059 2.2246188382278542 1.688628010662448 1.0072225680138365 0.3114796997303573 0.1041819332558558 0.1155957163384056 0.2223047329091382 0.4732445906533414 0.7284504433708964 +Proteasome core complex beta subunit complex 4 6 2.2610148952796805 0.0237583347066459 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 1.0 0.0832836732680532 3.9104524570814734e-05 2.915330495677531e-05 +Intrinsic component of endoplasmic reticulum membrane 11 48 2.256076258653141 0.0240658556947706 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 0.0986286025003162 0.1184945425124205 0.001316320715177 5.493965560525705e-05 0.0012010966764003 +Golgi lumen 2 5 2.2500901967001123 0.0244432202673277 1.745679012345679 4.548148148148148 1.1368717941323 0.2457507117503182 1.2159484823715767 1.4039724163790972 1.161880305109492 0.2643265801751675 0.1266743042911767 0.1403531442218371 0.266209970857853 0.0419909810254146 0.2040147905672061 +Intrinsic component of golgi membrane 2 9 2.248850409679917 0.024522014946458 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.1629416191018168 0.1801156574188796 0.0614247268920475 0.0816409424117451 0.3375295111799605 +Protein phosphatase type 2a complex 0 7 2.237941634637454 0.0252248614910279 2.516990291262136 5.669902912621359 0.299168775918065 0.508393987248413 1.5223903885177978 0.8717614075761149 0.9411397025089426 0.3137875197040505 0.0654311950523822 0.0727733471903131 0.1432798584585485 0.3258327648280404 0.5514871371697274 +Nuclear inner membrane 5 20 2.235335225016474 0.0253953491608838 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.1629416191018168 0.1801156574188796 0.0614247268920475 0.0185450998789275 0.015487938148487 +Pore complex 1 8 2.231207287949161 0.0256674014501205 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.002269766977186 0.0028214739728005 0.0113213926532688 0.0630532374058985 0.2004310968060411 +Azurophil granule lumen 10 39 2.206821869614789 0.0273265065522179 12.118932038834952 41.25728155339806 -0.033426136567579 0.3776020138210581 4.31782609196223 3.0753988435553 1.7699755963815147 0.3570217435028845 0.0023266014087451 0.0031900731237819 0.0003347950757343 0.0001333900408092 0.0002066062598538 +Main axon 6 11 2.1611587329564106 0.0306830799302684 2.8398058252427183 9.6747572815534 0.1979656608956029 0.5746071872544977 2.030966091116993 2.0927623054951434 0.8321846726751543 0.2972766207001112 0.1117415456151005 0.1239247827595126 0.2372212797486779 0.1476943407876319 0.0105347068278647 +Coated vesicle 13 78 2.097543387895948 0.0359455005565971 21.15776699029126 89.28398058252426 0.7996411773181966 0.4463095457932411 7.252509633536616 8.542551157088123 1.3406722753228342 0.3892656029628454 0.001483512667487 0.002437424715989 0.0441639298720413 0.0036902178216933 0.0193034969615419 +Proteasome core complex 6 13 2.086750253104653 0.0369107160862447 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 1.0 1.0 0.1515272625734178 3.982551880468722e-05 8.061508148359063e-06 +Tim23 mitochondrial import inner membrane translocase complex 2 6 2.084211694863498 0.0371409154373605 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0009327817545055 0.0011617774889038 0.0047533286028597 0.0020298329670106 0.0142438301551866 +Endoplasmic reticulum golgi intermediate compartment membrane 5 21 2.0837326563183187 0.0371844920120967 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 0.0224004683642894 0.0275080115441885 0.0157478410048603 0.0105760203706863 0.0505698485029352 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4b9e8c242bebd78e219885d4ef5db508205f10ca --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 889, + "title": "Average number of proteins per term", + "value": 27.628796400449943 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5b4420df89f9ea21a8b0734864b2f271a22caa0b --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8d5841f1fa98a6aec0695c051319080b26c8a883 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,274 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuolar lumen 0.5969393792563447 3.4954012815131956 0.0004733495163582 0.3435490786361327 0.4208077200424813 61 Q14108,P11117,P08236,P10619,P68371,P16278,P04066,P07437,O43681,Q8IV08,P50897,P54802,Q9BTY2,P78371,O00560,Q13510,P07602,P10253,Q8NHP8,P04062,Q9NZJ7,O14773,P15586 23 +Azurophil granule 0.550335165055666 3.025550959606344 0.0024818057899649 0.8901970321956694 0.532984159808703 65 P07602,P10253,O00560,Q9NZJ7,P16278,P42785,P04066,P78371,P07437,P08236,P10619,O43681,P68371,P15586,O15260 15 +Lysosomal lumen 0.6523542825065177 2.7788865035357526 0.0054545579589631 0.9922679029627206 0.532984159808703 34 P07602,P10253,Q8IV08,P50897,Q8NHP8,P04062,Q9NZJ7,P16278,P04066,O14773,P54802,Q14108,P11117,P08236,P10619,O43681,P15586,Q13510 18 +Membrane microdomain 0.4794398980530118 2.364885906493634 0.01803562621418 0.9999999060048562 0.5372942368427875 63 P21796,P50897,P09601,O15118,O14773,P07437,Q8WTV0,P05067 8 +Clathrin coated vesicle 0.5606245388269169 2.3229291123825773 0.0201829608885557 0.9999999865756278 0.5372942368427875 43 Q8NC96,O00443,Q5VW38,P42892,Q9Y5X1,Q14108,Q96AX1 7 +Outer membrane 0.4926877544150483 2.311464447137698 0.0208072147502966 0.9999999923821196 0.5372942368427875 79 P21796,P45880,Q9NZJ7,Q13505,Q9NX63,P09601,Q8N4H5,Q9Y512,Q86WA6,Q9BWH2,Q99720,Q9NS69,O43169 13 +Azurophil granule membrane 0.6500614418049272 2.297496265314477 0.0215904758721676 0.9999999962599532 0.5372942368427875 20 P07602,P42785,O15260,P10253 4 +Proteasome core complex beta subunit complex 0.8607724193811946 2.2610148952796805 0.0237583347066459 0.9999999994794356 0.5372942368427875 6 P20618,P49720,P49721,P28070 4 +Intrinsic component of endoplasmic reticulum membrane 0.5329633973391341 2.256076258653141 0.0240658556947706 0.9999999996065988 0.5372942368427875 48 Q15629,Q8N4V1,Q9Y282,Q86YN1,Q86XL3,Q8TB61,Q9GZP9,Q9NZ01,O43826,Q9NQC3,O75844 11 +Golgi lumen 0.8924374993646706 2.2500901967001123 0.0244432202673277 0.9999999997210552 0.5372942368427875 5 P05067,O00461 2 +Intrinsic component of golgi membrane 0.7841230275205515 2.248850409679917 0.024522014946458 0.999999999740383 0.5372942368427875 9 Q8TB61,Q9Y282 2 +Nuclear inner membrane 0.6394620815760274 2.235335225016474 0.0253953491608838 0.9999999998829104 0.5372942368427875 20 Q14728,Q9H1E5,Q8IXM6,Q99720,O75844 5 +Pore complex 0.8138877543791033 2.231207287949161 0.0256674014501205 0.9999999999086454 0.5372942368427875 8 P21796 1 +Azurophil granule lumen 0.558112753341671 2.206821869614789 0.0273265065522179 0.9999999999799212 0.5372942368427875 39 O00560,P16278,P04066,P78371,P07437,P08236,P10619,O43681,P68371,P15586 10 +Main axon 0.7247627006704008 2.1611587329564106 0.0306830799302684 0.9999999999990709 0.5566787358777271 11 Q12955,P04350,P78559,Q15334,P05067,Q14168 6 +Coated vesicle 0.4702939891583723 2.0975433878959477 0.0359455005565971 0.9999999999999928 0.5699485068750688 78 Q8NC96,Q5VW38,O00443,P20645,P24390,Q9Y282,P42892,Q9Y5X1,Q14108,P05067,Q96AX1,P49257,O95070 13 +Proteasome core complex 0.6875809506975922 2.086750253104653 0.0369107160862447 0.999999999999997 0.5699485068750688 13 P60900,P49720,P28070,P28074,P20618,P49721 6 +Tim23 mitochondrial import inner membrane translocase complex 0.8179595142545408 2.084211694863498 0.0371409154373605 0.9999999999999976 0.5699485068750688 6 Q99595,O60830 2 +Endoplasmic reticulum golgi intermediate compartment membrane 0.6023367531383094 2.0837326563183187 0.0371844920120967 0.9999999999999976 0.5699485068750688 21 P24390,Q9Y282,Q96GC9,O15260,O95070 5 +Secretory granule membrane 0.4418583423021743 1.9590363602052576 0.0501085287511666 1.0 0.6240533816301613 65 P63167,P35613,P30519,P07602,P10253,Q9BXS5,Q93050,Q9NZJ7,P42785,Q4KMQ2,O15260 11 +Inner mitochondrial membrane protein complex 0.4495022691534645 1.9425654863955155 0.052068680389844 1.0 0.6255277954942072 73 O14949,Q9BPX6,O60830,Q99595,Q9NX63,Q9Y6M9,Q13505,Q86Y39,P14406,P03886,P00403,Q9Y512,P00846,O75964,Q9UDW1,O14925,Q96CU9 17 +Intrinsic component of mitochondrial inner membrane 0.5326063514650379 1.9014154330739184 0.0572476196516456 1.0 0.6538407371047378 31 O60830,O75880,Q99595,Q9NX63,Q13505,Q9Y512,O14925 7 +Gemini of coiled bodies 0.8059718253164658 1.9005013822001868 0.0573673537617205 1.0 0.6538407371047378 5 Q8TEQ6,Q9UHI6 2 +Cytosolic ribosome 0.4419998032373135 1.8649706620011208 0.0621855166098062 1.0 0.6542280123543329 73 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P05198,P62280,P46778,P18077,P62249,P82912,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 44 +Endoplasmic reticulum golgi intermediate compartment 0.4953824438742228 1.8518510510924089 0.0640472144998676 1.0 0.6544594677055438 45 Q9Y217,P24390,Q9Y282,Q96GC9,Q02818,P80303,P49257,O15260,O95070 9 +Excitatory synapse 0.7535732376976395 1.8120353993648943 0.0699807269423504 1.0 0.6689555510940813 6 Q9UQB8 1 +Smn complex 0.7797257054864817 1.7920175375625491 0.0731301567929878 1.0 0.6747560350529633 5 Q8TEQ6,Q9UHI6,Q16637 3 +Outer mitochondrial membrane protein complex 0.6089918505342038 1.786308412723858 0.0740493355202041 1.0 0.6747560350529633 15 Q13505,Q8N4H5,Q9Y512,Q9NS69 4 +Cytoplasmic ubiquitin ligase complex 0.7124496387200383 1.7840018425924893 0.0744233657512114 1.0 0.6747560350529633 8 Q9BUN8,Q9GZP9,Q9UBU6,Q9NT62,Q13617 5 +Schaffer collateral ca1 synapse 0.6057482420143236 1.7685144215992057 0.0769749434034727 1.0 0.6808466912351643 15 Q9BVA1 1 +Platelet alpha granule lumen 0.6526371263484149 1.7605218994553795 0.0783193577336427 1.0 0.6808466912351643 10 Q8NBX0 1 +Endosome lumen 0.8388926980719619 1.704524198978261 0.0882831991043828 1.0 0.7003761541372711 4 Q9UIQ6 1 +Presynaptic cytosol 0.8343965313100425 1.6869149830624297 0.0916197006246628 1.0 0.7003761541372711 4 Q9UQB8 1 +Clathrin coated vesicle membrane 0.5275253748018083 1.6792022347265647 0.0931126366041734 1.0 0.7003761541372711 22 Q8NC96,P20645,Q96CW1,P02786,Q14677,Q14108,Q9NVZ3,Q15286 8 +Intrinsic component of organelle membrane 0.4733756567700548 1.6786082419770691 0.0932284192149042 1.0 0.7003761541372711 121 Q99595,Q9NX63,Q86XL3,Q9NZ01,Q14739,O60830,Q8N4V1,Q9Y282,Q86YN1,O15118,O43826,Q9NQC3,O14925,O75844,O95070,Q15629,O75880,Q13505,Q8TB61,Q9GZP9,Q9Y512,Q9BPX6,P42892,O95470,Q9BWH2 25 +Er ubiquitin ligase complex 0.7522892618946719 1.6775646421978216 0.0934321201712176 1.0 0.7003761541372711 5 Q9BUN8,Q9GZP9 2 +Platelet alpha granule 0.586093559277783 1.660059727800243 0.0969024375240543 1.0 0.7003761541372711 15 Q8NBX0 1 +Apical plasma membrane 0.4742871216062999 1.6512607146355007 0.0986853503664599 1.0 0.7041100651108825 44 P08183,Q99808,Q9Y6M7,P21281,Q16625,Q9Y4G8,P53985,O43865 8 +Cis golgi network 0.6126447910662426 1.6497059018272129 0.099003102518403 1.0 0.7041100651108825 12 O00461,P24390 2 +Caveola 0.5610079146378464 1.6021787538758543 0.1091160868658107 1.0 0.7577545671109798 17 P09601 1 +Neuron projection terminus 0.5733521092625619 1.5891991781520955 0.1120154319739341 1.0 0.7601657940826524 15 Q13641,Q9UQB8 2 +Nuclear envelope lumen 0.729962473501566 1.5837221801976085 0.1132569550739241 1.0 0.7627684322781714 5 P07437 1 +Clathrin coated endocytic vesicle membrane 0.596659840458467 1.566475759754335 0.1172372790993447 1.0 0.7647081930194074 12 Q14108,P20645,P02786,Q96CW1 4 +Myelin sheath 0.6039182096883265 1.5596124645605531 0.1188514891540724 1.0 0.7647081930194074 11 P04350 1 +Ciliary tip 0.6892973489974659 1.533651650062782 0.1251153744272111 1.0 0.7720393176961496 6 P63167,Q8NCM8,Q9BW83 3 +Plasma membrane raft 0.5043978943183569 1.526247671807617 0.1269481951982964 1.0 0.7720393176961496 22 P09601 1 +Intrinsic component of mitochondrial membrane 0.4474017853896944 1.5209868949933978 0.1282631260199833 1.0 0.7720393176961496 48 Q9BPX6,O60830,O75880,Q99595,Q9NX63,Q13505,Q9Y512,Q9BWH2,O14925 9 +Tight junction 0.4805005181488428 1.5068346754369015 0.1318530390145114 1.0 0.7766736326469589 28 P50552,Q86UE4,Q8NI35,P11802,Q12955,P16989,Q4VCS5,Q8WUM4,Q16625,Q9NR77,Q68EM7,Q9Y4G8,Q5T2T1,Q9H8V3 14 +Cytosolic small ribosomal subunit 0.4761564477463264 1.473304769448485 0.1406688752287406 1.0 0.7987569758065532 27 P46781,P15880,P62280,P46782,P08708,P62847,P62753,P62241,P05198,P62841,P62701,P62244,P62277,P62249,P82912,P62266,P23396,P46783 18 +Ccr4 not complex 0.7798314408551061 1.47184470614089 0.1410628179995825 1.0 0.7987569758065532 4 Q9UKZ1 1 +Cytochrome complex 0.5452208732192894 1.4684630258366016 0.1419784925454612 1.0 0.7988536700817408 16 P00403,O14949,Q9UDW1,P14406 4 +Cytosolic large ribosomal subunit 0.4419513826680448 1.4222786895516788 0.1549453628246868 1.0 0.8191047019062357 46 Q9Y3U8,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,Q02543,P62917,P83731,P62888,P46779,Q02878,P61313,P35268,P46778,P18077,P36578,P47914,P61254,Q07020,P83881 25 +Ficolin 1 rich granule membrane 0.5270734549130776 1.4031329482353316 0.1605771976754813 1.0 0.8191047019062357 17 P10253,P42785 2 +Clathrin coated endocytic vesicle 0.5323778131619128 1.3944458370730255 0.1631830145992276 1.0 0.8191047019062357 16 Q14108,P20645,P02786,Q96CW1 4 +Hrd1p ubiquitin ligase erad l complex 0.7459650196761788 1.337503688741574 0.1810582790116854 1.0 0.8426648729710187 4 Q9GZP9 1 +Microtubule 0.4349586531045724 1.3356246965146454 0.181671973792638 1.0 0.8426648729710187 115 Q9H6D7,Q9BVA1,P04350,Q9BUF5,P78371,P07437,Q9UQB8,Q8WUX9,Q13509,P68371,Q13885 11 +Nucleoid 0.4538550643168536 1.3312133233897927 0.1831188286798049 1.0 0.8426648729710187 33 P21796,P45880 2 +Specific granule membrane 0.5383519469025697 1.300205073120789 0.1935306923559023 1.0 0.8426648729710187 13 P30519 1 +Apical part of cell 0.386439137924538 1.2843421151584704 0.1990222769900662 1.0 0.8426648729710187 58 P08183,Q8NCM8,Q86UE4,Q9UPY5,P04920,Q8NI35,Q99808,Q9Y6M7,P14550,Q16625,P21281,P05067,P35241,Q9Y4G8,Q15154,P53985,O43865 17 +Nuclear outer membrane 0.5562268654379307 1.2765803656861845 0.2017504373329051 1.0 0.8426648729710187 10 Q8IWB1,Q99720 2 +Juxtaparanode region of axon 0.7298082526987677 1.2733441349730972 0.2028959517891468 1.0 0.8426648729710187 4 Q15334 1 +Neuromuscular junction 0.5109487853876089 1.270293441475853 0.2039801235188407 1.0 0.8426648729710187 16 Q12955,Q15334,P05067,O43760 4 +Chloride channel complex 0.7172246078830906 1.2233985431841674 0.2211792033392308 1.0 0.8512048128509792 4 Q4KMQ2 1 +Wash complex 0.7083298551482546 1.1881282153489 0.2347828996759593 1.0 0.8554801341189322 4 Q2M389 1 +Basal part of cell 0.4113592830396055 1.176711138498673 0.2393108205560916 1.0 0.8613251800581598 47 P35613,Q99808,Q9BY67,Q12955,Q9Y6M7,Q7Z460,P42785,P15291,Q14168,P53985 10 +Replisome 0.5359155037511577 1.1731610678771809 0.2407312211220436 1.0 0.8623253771543621 10 P28340,P27694,P12004,P09884,P35244,P15927 6 +Ciliary rootlet 0.8625372639947031 1.171174345107633 0.2415287051872172 1.0 0.8623253771543621 2 P05067 1 +Mitotic spindle microtubule 0.6051298803913214 1.162814754497089 0.244904669538702 1.0 0.8708810048796245 6 Q9H6D7 1 +Endocytic vesicle membrane 0.4265990187114944 1.1603504185728577 0.2459061647076839 1.0 0.8709584877495259 38 P20645,Q93050,Q14108,Q15334,Q8WTV0 5 +Phagophore assembly site membrane 0.6943333210275824 1.13272064364831 0.2573315856756824 1.0 0.8971285477085554 4 Q7Z3C6 1 +Vacuolar membrane 0.4042814616527457 1.1229012096891062 0.2614794537112188 1.0 0.9031165808319228 104 P42785,Q14108,O75503,Q8WTV0,P10619,Q96AX1,Q8WUX9,Q7Z3C6,O15118,Q8IV08,Q93050,Q9UIQ6,O15260,P10253,P07602,P20645,P04062,Q9NZJ7,P42892,P21281 20 +Endocytic vesicle 0.3738623683587762 1.106555041110755 0.2684863544533551 1.0 0.9031165808319228 76 P33176,O00461,P20645,Q96CW1,Q93050,Q4VCS5,Q14108,Q16625,Q15334,Q8WTV0,Q9Y4G8,Q9Y487,Q9H4M9 13 +Polysomal ribosome 0.4242229896368147 1.1025916360976626 0.2702045440369731 1.0 0.9031165808319228 24 Q9Y3U8,Q02543,P62917,P62266,P83881 5 +Late endosome 0.3566717099999 1.1009074378117734 0.2709369446035401 1.0 0.9031165808319228 61 P07602,P20645,Q8IV08,Q9NZJ7,O15118,Q9GZP9,Q14108,Q9Y4G8,Q96AX1,Q8WUX9,P42858,Q7Z3C6 12 +Respiratory chain complex iv 0.5215954798501242 1.100212058171541 0.2712397380001388 1.0 0.9031165808319228 10 P00403,P14406 2 +Postsynaptic density membrane 0.5862036226598043 1.09439071925152 0.273783652552328 1.0 0.904064871265736 7 Q15334,Q99720 2 +Postsynaptic specialization membrane 0.513658877347996 1.0923421477228854 0.2746827411819734 1.0 0.904064871265736 11 Q15334,Q99720 2 +Haus complex 0.6824699196635692 1.085883814372146 0.2775303986561539 1.0 0.904064871265736 4 Q9H6D7 1 +Ciliary plasm 0.4827753547673182 1.0765165889379835 0.2816962858636862 1.0 0.904064871265736 15 Q8NCM8,Q8WWQ0,P04350,P49454,Q15019 5 +Respiratory chain complex iii 0.5802728743977166 1.0679804300470968 0.2855293395662444 1.0 0.9083883839643558 7 O14949 1 +Smn sm protein complex 0.5333101490686968 1.0635958241452008 0.2875118349339547 1.0 0.9096014991326894 9 Q8TEQ6,Q9UHI6,P62304,Q16637 4 +Postsynaptic cytosol 0.5816822343324375 1.0593998197894103 0.2894177317282245 1.0 0.9111241539040678 6 Q9UQB8 1 +F actin capping protein complex 0.6062427329718278 1.0580275177515812 0.2900428971370654 1.0 0.9111241539040678 5 P47755,P35611 2 +Respirasome 0.4086704955005675 1.0493506439464495 0.2940167652527499 1.0 0.9158100463754664 41 Q9Y6M9,Q86Y39,P14406,P03886,O14949,Q9UDW1,Q96CU9 7 +Axon initial segment 0.8280887711162663 1.03725481588029 0.2996171175099369 1.0 0.9158100463754664 2 Q12955 1 +Ciliary membrane 0.6665992712271727 1.0234792285133676 0.3060813160068354 1.0 0.9223942031528024 4 Q9H4M9 1 +Escrt complex 0.5213376712990937 1.0054908693241869 0.3146605439007399 1.0 0.9381141152573226 9 Q8WUX9 1 +Proteasome complex 0.4024702377219986 0.998011362066738 0.318273849102304 1.0 0.9381141152573226 41 P60900,P49720,P28070,P28074,P25788,P20618,P49721,Q15386,O43396 9 +Autophagosome 0.4093445386088456 0.9881351761332988 0.3230864503142179 1.0 0.9381141152573226 26 Q96GC9,Q96AX1,Q8WUX9,P42858,Q7Z3C6 5 +Golgi membrane 0.4029913938189262 0.9776611942351416 0.3282419205811506 1.0 0.941313120634332 117 P40616,P24390,Q9Y296,Q14108,Q15334,P49257,Q8IZA0,Q7Z3C6,O00461,Q8N4V1,Q9Y282,Q9BXS5,P48739,O14579,O95070,P35613,Q9BW83,Q8IV08,Q8TB61,O15260,Q15436,O95197,Q15392,Q8NCH0,Q16739,Q7LGA3 26 +Coated vesicle membrane 0.3835272213976807 0.9716560434990448 0.3312216914785062 1.0 0.9428645500391112 49 Q8NC96,Q15436,P20645,P24390,P02786,Q96CW1,Q14108,Q9NVZ3,Q15286,O14579,Q9NR31,P49257 12 +Scf ubiquitin ligase complex 0.5580856994477057 0.9695070498638658 0.3322922644823189 1.0 0.9428645500391112 7 Q96K76,Q13309,Q13617 3 +Cytoplasmic region 0.3589037463418917 0.9635045060724186 0.3352944039298315 1.0 0.9428645500391112 57 P33176,Q8NCM8,Q13363,Q8WWQ0,P78559,Q8N2K0,P04350,Q7Z460,P49454,Q92572,P56545,Q15334,Q14168,Q9UQB8,P43034,Q15554 16 +Mediator complex 0.4819416465970147 0.9592658852561858 0.337424816765655 1.0 0.9428645500391112 12 P11802,Q15648 2 +Lipid droplet 0.4054987390930882 0.9574736810850938 0.3383282243672401 1.0 0.9428645500391112 27 Q15042,Q99720,Q8NBX0,O43760 4 +Trans golgi network 0.3676890121627851 0.9532544990216302 0.3404611393822874 1.0 0.9428970495665218 54 O00443,P20645,P04062,Q9Y5X1,Q9NPR9,P05067,Q7Z3C6 7 +Cytoplasmic dynein complex 0.5515102593850464 0.940462259438879 0.346980499640463 1.0 0.9435076004095228 7 P63167,Q8NCM8,Q9UJW0,Q96FJ2 4 +Platelet dense tubular network 0.8019211659489924 0.9372526460369636 0.3486286150062336 1.0 0.9435076004095228 2 Q9H4M9 1 +Platelet dense tubular network membrane 0.8019211659489924 0.9372526460369636 0.3486286150062336 1.0 0.9435076004095228 2 Q9H4M9 1 +P body 0.4029253439560748 0.9361963461922678 0.3491721040885636 1.0 0.9435076004095228 31 Q9HCE1,P60900,Q93062,O15514,P19474,Q96F86,Q9NZN8 7 +Apical junction complex 0.3996011299986491 0.915225677283578 0.3600731673345285 1.0 0.955937058633448 33 Q9P1Y5,P50552,Q86UE4,Q8NI35,P11802,Q12955,P16989,Q4VCS5,Q8WUM4,Q16625,Q9NR77,Q68EM7,Q9Y4G8,Q5T2T1,Q9H8V3 15 +Kinetochore microtubule 0.5469952697176642 0.9076067272048116 0.3640860388200422 1.0 0.9582692469923624 6 Q8WUX9 1 +Prefoldin complex 0.6358717670945349 0.9038552707383368 0.3660721496633341 1.0 0.9590650432352742 4 Q99471,O15212 2 +Paraspeckles 0.5455584977116783 0.9013689721237522 0.3673921729569549 1.0 0.9590650432352742 6 Q15233,Q8WXF1 2 +Dendritic shaft 0.5443777936512817 0.8962467048227731 0.3701210163265975 1.0 0.9590650432352742 6 P05067,Q14168,Q9UQB8 3 +Cytosolic region 0.5380280503992478 0.8811844937306945 0.3782179706598036 1.0 0.9601872746777516 7 Q9UQB8 1 +Cyclin dependent protein kinase holoenzyme complex 0.4595707439194761 0.8726829648025871 0.382835905450664 1.0 0.9614155930667806 13 P11802,P06493,P12004,Q00534,P14635 5 +Photoreceptor inner segment 0.626414444641028 0.8674643943528894 0.3856876124778299 1.0 0.9631356390246932 4 P35613,Q96HR9 2 +Dna polymerase complex 0.4860243631391487 0.8355326205658848 0.403417888162995 1.0 0.97969609199612 9 P09884,Q07864,Q9NRF9,P28340 4 +Phagophore assembly site 0.5295457118601075 0.8322224414772571 0.4052833990192432 1.0 0.97969609199612 6 Q96GC9,Q7Z3C6 2 +Golgi associated vesicle 0.3874736242270096 0.8298984648314967 0.4065961929388053 1.0 0.97969609199612 26 P05067,P24390 2 +Vacuole 0.4500262018752174 0.8233092287800841 0.4103321668264628 1.0 0.97969609199612 195 Q15165,P42785,Q8NCC3,Q14108,O75503,Q8WTV0,P11117,P08236,Q9Y487,P10619,Q96AX1,Q8WUX9,P68371,P42858,Q9Y4P8,Q7Z3C6,P38435,P33176,Q9BXS5,Q96CW1,Q12955,P16278,P04066,O15118,P15291,P07437,Q9UHG3,O43681,Q15642,Q8IV08,P50897,Q93050,Q9UIQ6,P54802,Q9BTY2,P78371,O00560,O15260,Q13510,P10253,P07602,P20645,Q8NHP8,P04062,Q05639,Q9NZJ7,P42892,Q96GC9,O14773,P21281,Q9HAD4,Q8TBX8,P15586 53 +Ruffle 0.3613890088822351 0.8143611834879043 0.4154380687266756 1.0 0.97969609199612 51 P63167,Q9Y217,Q4VCS5,Q9Y5X1,P21281,Q9UQB8 6 +Side of membrane 0.3329824146840591 0.8078962619504387 0.4191503033694528 1.0 0.97969609199612 64 P08183,Q05639,O96005,P00390,P02786,P42892,Q4VCS5,Q9Y5X1,P15291,Q8TCT9,Q15334,O15111,P10619,P31689 14 +Proton transporting two sector atpase complex proton transporting domain 0.4584174817142886 0.8071258556071452 0.4195939772006021 1.0 0.97969609199612 11 Q93050,O75964,P00846 3 +Trna splicing ligase complex 0.5235119752649463 0.8063707175338726 0.4200291259177457 1.0 0.97969609199612 6 Q9BVC5,Q52LJ0 2 +Mitochondria associated endoplasmic reticulum membrane 0.4791847647143881 0.8030006943309816 0.4219743332469141 1.0 0.97969609199612 9 Q96N66 1 +External side of plasma membrane 0.3968218978300284 0.8023207802637349 0.4223674249513984 1.0 0.97969609199612 22 P08183,P00390,O96005,P42892,Q4VCS5,P15291 6 +Intrinsic component of nuclear inner membrane 0.5222136842118623 0.8008246067784047 0.4232331915368781 1.0 0.97969609199612 6 Q14739,O94901 2 +Intrinsic component of plasma membrane 0.3413794712906929 0.7924814626848578 0.4280799963858457 1.0 0.97969609199612 73 P35613,P53985,P20645,O96005,Q9UIQ6,O15118,Q15334,P10586,Q8WTV0,P05067,Q9Y4G8,Q13641,O00560,O43657,O95864,Q99805 16 +Mib complex 0.4732685703861342 0.7749995687218478 0.4383399144302369 1.0 0.97969609199612 9 Q13505,Q9Y512 2 +Methylosome 0.4913118622284788 0.7656523211599912 0.443883203713316 1.0 0.9816223087092985 8 P62304 1 +Ribbon synapse 0.7518386824765845 0.7453728365680604 0.4560463602692306 1.0 0.987000202510835 3 P56545 1 +Blood microparticle 0.4118291382261476 0.7208081692324241 0.4710275485206474 1.0 0.9903318057341964 17 P04062,P07737,Q08380,O00560,P38435 5 +Tor complex 0.7379058979456756 0.6995971517691009 0.4841789218042323 1.0 0.9903318057341964 3 Q9Y4R8,P42345 2 +Torc1 complex 0.7379058979456756 0.6995971517691009 0.4841789218042323 1.0 0.9903318057341964 3 Q9Y4R8,P42345 2 +Derlin 1 retrotranslocation complex 0.5815811048075084 0.6989503585428731 0.4845830545493537 1.0 0.9903318057341964 4 Q9BUN8,Q8TCT9 2 +Polysome 0.3552756997863676 0.6539917530107919 0.5131171188528834 1.0 1.0 45 Q9Y3U8,Q06787,P84098,P35580,P60900,P62753,Q02543,P62917,P62701,O15372,P83731,P62266,P62888,P25786,Q02878,P08670,P23396,P20290,Q07020,P83881 20 +Transport vesicle 0.339554435088456 0.650568772842806 0.5153248937223998 1.0 1.0 84 Q15436,O00461,P20645,P50897,P24390,Q92572,O43760,Q9GZM5,Q15334,P05067,O14579,P49257,O15260 13 +Neuron projection cytoplasm 0.3645541454655572 0.6502440482710766 0.5155345924241272 1.0 1.0 32 P33176,P78559,Q8N2K0,Q92572,Q15334,Q14168,Q9UQB8,P43034,Q15554 9 +Trapp complex 0.7227558794302807 0.6498881015790949 0.5157645044343409 1.0 1.0 2 Q9Y296 1 +Axon cytoplasm 0.385208002222775 0.6493565108567463 0.5161079669374853 1.0 1.0 20 P33176,Q92572,Q14168,P43034,Q15554 5 +Mismatch repair complex 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 1.0 3 P52701 1 +Multimeric ribonuclease p complex 0.718798492605347 0.6381939138012691 0.5233474585611786 1.0 1.0 3 O95707 1 +Ribonuclease mrp complex 0.718798492605347 0.6381939138012691 0.5233474585611786 1.0 1.0 3 O95707 1 +Anchored component of membrane 0.4412662291562307 0.6264400860400722 0.5310263235843116 1.0 1.0 9 Q15334,Q15286 2 +Clathrin coated pit 0.3863916925336735 0.6256000239979261 0.5315773230412937 1.0 1.0 19 Q8NC96,Q96CW1,P02786,Q01968,Q9NVZ3,P05067,Q15286,P56377 8 +Nadh dehydrogenase complex 0.3695803986863554 0.6230263863918065 0.5332671823884712 1.0 1.0 22 Q9Y6M9,P03886,Q96CU9 3 +Dendrite cytoplasm 0.4214844700613704 0.6223299066835143 0.5337249598878548 1.0 1.0 11 P33176,Q15334,Q9UQB8 3 +Neuronal ribonucleoprotein granule 0.7118777340632453 0.6163877764805912 0.5376386188888942 1.0 1.0 3 Q99729 1 +Epsilon dna polymerase complex 0.7117384123440788 0.6159513258366033 0.5379266450984042 1.0 1.0 3 Q9NRF9 1 +Proton transporting v type atpase complex 0.4365872411640657 0.605231634691708 0.545025099075743 1.0 1.0 9 Q93050,P21281 2 +Tertiary granule 0.3569984877551846 0.6025950429159624 0.5467781188603591 1.0 1.0 37 P63167,P10253,Q93050,P42785,Q4KMQ2,Q13510 6 +Endoplasmic reticulum tubular network 0.4164413259112167 0.5977540961985447 0.550004023986163 1.0 1.0 11 Q00765,Q9H6H4,Q15042,Q9NQC3 4 +Proton transporting atp synthase complex coupling factor f o 0.4528575669657149 0.59645755765878 0.5508695991788195 1.0 1.0 8 P00846 1 +Clathrin vesicle coat 0.4334012566144026 0.590880386054674 0.5546005687962459 1.0 1.0 9 Q8NC96,Q9NVZ3,Q96CW1 3 +Emc complex 0.489649831623921 0.5826798392401847 0.5601088475943776 1.0 1.0 5 Q5J8M3,Q8N4V1 2 +Microtubule associated complex 0.3479812611892711 0.5816205443177119 0.5608223016143092 1.0 1.0 44 P63167,Q9H6D7,P33176,Q8NCM8,Q9UJW0,O94927,P78559,P49356,P46821,Q96S59,P43034 11 +Glial cell projection 0.4684648260329787 0.5781423409275305 0.5631680229544096 1.0 1.0 6 P05067,Q06787,Q9UPY5,Q8IXJ6 4 +Autophagosome membrane 0.4119291526224501 0.5759352345438884 0.5646589587292543 1.0 1.0 11 Q8WUX9,Q7Z3C6 2 +Gamma secretase complex 0.6999006293474725 0.5731010668557622 0.5665762649292267 1.0 1.0 2 Q92542 1 +Aminoacyl trna synthetase multienzyme complex 0.4110654188948368 0.5717777955132541 0.5674725220944743 1.0 1.0 11 Q9P2J5,Q15046,Q13155,P41252,O43324,P47897,Q12904,P14868 8 +Proton transporting two sector atpase complex 0.3659134019169179 0.5634169743502785 0.5731509812749618 1.0 1.0 21 Q93050,P21281,Q9Y487,P00846,O75964 5 +Organelle membrane contact site 0.3908485340622543 0.5633929698391239 0.5731673232645444 1.0 1.0 15 Q96N66 1 +Tertiary granule membrane 0.4107656416007059 0.5515988681527554 0.5812232120683958 1.0 1.0 10 P10253,Q4KMQ2 2 +Zymogen granule membrane 0.6916197416363103 0.5461733896369089 0.5849467560587671 1.0 1.0 2 P49755 1 +Astrocyte projection 0.6837819510030624 0.5305662887565828 0.5957193616594412 1.0 1.0 3 P05067 1 +Sperm principal piece 0.6772059305177215 0.5111671317603494 0.6092340317333855 1.0 1.0 3 Q9BW83 1 +Dendrite membrane 0.6739343444071403 0.5016213061016809 0.6159339292272099 1.0 1.0 3 Q14168 1 +Outer kinetochore 0.4427550975533648 0.4836855366953151 0.6286090592767302 1.0 1.0 7 Q8NFC6,Q96BD8,P49454,Q8IX90,P14635 5 +Platelet dense granule 0.6649470557408257 0.4757722543670369 0.6342366385873031 1.0 1.0 3 Q08380 1 +Ap 3 adaptor complex 0.664218333861587 0.4737009762427622 0.6357131570847163 1.0 1.0 3 Q92572 1 +Filopodium 0.3395009651388575 0.4719557126731573 0.6369584002373347 1.0 1.0 31 Q13509,Q9UQB8 2 +Nuclear replication fork 0.3702160088463577 0.4695668751002564 0.6386644954207186 1.0 1.0 16 Q9H4L7,P28340,P27694,Q7L590,P12004,P09884,Q9UNS1,P35244,P15927 9 +Spindle microtubule 0.3379382550342945 0.4678153565187451 0.6399166378643841 1.0 1.0 29 Q9H6D7,P43034,Q8NFC6,Q7Z460,Q8WUX9 5 +Specific granule 0.3374093676159031 0.4604553658304595 0.6451894019914008 1.0 1.0 30 P30519,Q4KMQ2 2 +Cell body 0.333108700545799 0.4502726984727325 0.6525138223383753 1.0 1.0 97 P50897,P04350,Q7Z460,P46779,Q9UKA9,P78371,P07437,P05067,P10586,Q9Y4G8,Q9UQB8,P43034 12 +Clathrin coat 0.3766381292873095 0.4453210635008858 0.6560877480354677 1.0 1.0 13 Q8NC96,Q9NVZ3,Q14677,Q96CW1 4 +Vcp npl4 ufd1 aaa atpase complex 0.4330240028241524 0.4420858456722306 0.6584270864953834 1.0 1.0 6 Q92890,O94888 2 +Cop9 signalosome 0.4149921748761752 0.4401139799516138 0.6598545571586272 1.0 1.0 8 Q7L5N1,Q92905,Q99627,Q9BT78,P61201 5 +Rough endoplasmic reticulum 0.3341226727444922 0.4379766446797339 0.6614032139261901 1.0 1.0 30 Q9Y5M8,P49458,Q9UPY5,Q8TCT9,Q02878,P05067,Q9UQB8,P62266 8 +Dynein complex 0.3973174406285923 0.4344971121041572 0.6639274914668087 1.0 1.0 9 P63167,Q8NCM8,Q9UJW0,Q96FJ2 4 +Copii coated er to golgi transport vesicle 0.3303078768292026 0.4326014602930257 0.6653043283808584 1.0 1.0 26 O95070,P49257,P05067,Q9Y282 4 +Eukaryotic translation initiation factor 2 complex 0.6471172962226606 0.4262108485041334 0.6699542131671992 1.0 1.0 3 P05198,Q9BY44 2 +Early endosome 0.3236795904472435 0.4255190379851897 0.6704583462355131 1.0 1.0 90 Q96J02,P02786,Q9BUN8,Q15334,Q96AX1,Q9UNH7,P42858,Q9P258,Q5VW38,O14786,O95630,Q8N4V1,P05067,Q92542,O60749,Q8IV08,Q9UIQ6,Q9GZP9,Q9UBQ0,P62820,Q7Z3U7,Q13510,Q96A57,Q9H4M9 24 +Rna polymerase ii core complex 0.4268452872273198 0.4195732321054589 0.6747972463929526 1.0 1.0 6 P30876 1 +Pericentriolar material 0.6472341835044805 0.4113710386519323 0.6808004868118573 1.0 1.0 2 Q15154 1 +Proton transporting v type atpase v0 domain 0.6343819812959758 0.3923140550319077 0.6948261799424689 1.0 1.0 3 Q93050 1 +Vacuolar proton transporting v type atpase v0 domain 0.6343819812959758 0.3923140550319077 0.6948261799424689 1.0 1.0 3 Q93050 1 +Dendrite terminus 0.6305500331345313 0.3823744435223625 0.702183643890764 1.0 1.0 3 Q7L576,P07900 2 +Dendritic growth cone 0.6305500331345313 0.3823744435223625 0.702183643890764 1.0 1.0 3 Q7L576,P07900 2 +Rna polymerase ii transcription repressor complex 0.6299525275715157 0.3808357046702047 0.7033251636543436 1.0 1.0 3 Q14919 1 +Paranode region of axon 0.6346472341835137 0.3764443435640011 0.7065865848537634 1.0 1.0 2 Q8IXJ6 1 +Distal axon 0.2877500739596907 0.3702398348748036 0.7112037981701549 1.0 1.0 61 Q13641,Q13509,Q99720 3 +Mmxd complex 0.6225977468522161 0.3621452308213853 0.7172435049913861 1.0 1.0 3 P18074,P05141 2 +Nuclear outer membrane endoplasmic reticulum membrane network 0.4466515452305672 0.356021201008604 0.7218246879568855 1.0 1.0 272 P30519,P37287,P24390,Q9BUN8,P09601,Q86XL3,Q15042,Q9NZ01,Q14108,Q16850,Q9BRR6,Q14739,P49257,Q99720,O95864,Q7Z3C6,P38435,Q8N4V1,Q9Y282,P49458,Q8N2K0,Q86YN1,Q8IWB1,P48739,P16435,O43826,Q9UBU6,Q9HD20,Q9NQC3,O14579,O94966,Q6PIU2,P63241,Q96G23,Q9Y5P4,O75844,O43865,O95070,P43307,Q15629,Q2TAA5,P35613,Q8IV08,P48651,P67812,P07099,P51648,Q8TB61,Q969V3,Q9GZP9,Q15800,Q99943,O60725,O00560,O15260,P57088,Q9NZ08,Q15436,Q14534,O95197,Q96N66,O75915,Q96GC9,A1L0T0,O95470,Q6NUM9,A8CG34,Q15392 68 +Lamellipodium membrane 0.4080545700665037 0.35373654941491 0.7235363288320542 1.0 1.0 6 P50552 1 +Vesicle lumen 0.3374190826118875 0.3511128897025418 0.7255036582242673 1.0 1.0 112 O43681,P16278,P04066,Q8NBX0,P20618,Q9BTY2,P78371,P07437,P05067,P08236,P10619,O00560,P68371,P15586,O00764 15 +Endopeptidase complex 0.3119172960518436 0.3228205419600168 0.7468311550054341 1.0 1.0 47 P60900,P49720,P28070,P28074,P20618,P49721,O43396 7 +Insulin responsive compartment 0.4630427577063232 0.3127238692483783 0.7544904594528359 1.0 1.0 4 Q9Y4I1,P61026,P20338 3 +Cell body membrane 0.6020275851069842 0.3124272945599148 0.7547158097311004 1.0 1.0 3 P23634 1 +Rna polymerase iii transcription regulator complex 0.3945412682943113 0.3090948093234036 0.7572494075529075 1.0 1.0 6 Q969F1 1 +Transcription factor tfiiic complex 0.3945412682943113 0.3090948093234036 0.7572494075529075 1.0 1.0 6 Q969F1 1 +Axonal growth cone 0.3943615257047981 0.3085174953418738 0.7576885897240948 1.0 1.0 6 Q7L576,Q02790,P07900,Q92859,P08238 5 +Microbody membrane 0.3095298482280499 0.3005744325401793 0.7637390302550382 1.0 1.0 26 Q9NR77,P50542,P51648 3 +Crd mediated mrna stability complex 0.3910447761193968 0.2979450346740973 0.7657451152574422 1.0 1.0 6 O75534,O60506,Q9NZI8,P67809,Q00839 5 +Exocytic vesicle 0.3143744402488604 0.2936156455473483 0.7690516190749814 1.0 1.0 35 Q96A57,P50897,Q9Y296,Q92905,O43760,Q15334,Q15286,P05067,Q92542,Q9BT78 10 +Peptidase complex 0.2965034882236086 0.2904148638823976 0.7714988737431208 1.0 1.0 54 P60900,P49720,P28070,P67812,P28074,P20618,P49721,O43396 8 +Proteasome core complex alpha subunit complex 0.3867301755768978 0.284521332677951 0.7760108881596492 1.0 1.0 7 P60900 1 +Proton transporting atp synthase complex 0.3438380229493978 0.2841086137850609 0.7763271460069365 1.0 1.0 12 P00846 1 +Basolateral plasma membrane 0.3122968443490042 0.2832859673383683 0.7769576333385322 1.0 1.0 40 P35613,Q99808,P04920,Q9BY67,Q12955,Q9Y6M7,P15291,Q14168,P53985 9 +Dense core granule membrane 0.5935740311361486 0.2742251419648614 0.7839116079281052 1.0 1.0 2 Q709C8 1 +Dense core granule 0.5935740311361486 0.2742251419648614 0.7839116079281052 1.0 1.0 2 Q709C8 1 +Cortical endoplasmic reticulum 0.593242795627702 0.2734785911768368 0.7844853470795217 1.0 1.0 2 P50402 1 +Aggresome 0.3972302465892799 0.2712433615230985 0.7862038648879675 1.0 1.0 5 P28340 1 +Cytoplasmic side of endoplasmic reticulum membrane 0.446649298701165 0.2699075323158448 0.7872313922227916 1.0 1.0 4 Q8TCT9 1 +Golgi apparatus subcompartment 0.2889192386352908 0.2673180726076423 0.7892242729954337 1.0 1.0 72 P40616,O00443,O00461,P20645,Q9BXS5,Q9Y296,P04062,Q9Y5X1,Q15334,Q9NPR9,P05067,Q7Z3C6 12 +Organelle envelope lumen 0.3095199175554357 0.2634751142833569 0.7921844020484865 1.0 1.0 34 Q9BPX6,Q96AY3,P07437,P05067,O14925 5 +Cul2 ring ubiquitin ligase complex 0.5798054693105497 0.2632178696746695 0.792382658296209 1.0 1.0 3 Q13617 1 +Nucleotide excision repair complex 0.3889583877962737 0.2483878240777098 0.8038343534316845 1.0 1.0 5 P28340 1 +Sin3 complex 0.3879337035941779 0.245626179546975 0.8059716216204484 1.0 1.0 5 Q9NP50 1 +Transcription repressor complex 0.3270228944229819 0.2367556501124835 0.8128463594816728 1.0 1.0 14 P09429,Q9UHI6,Q13363,Q14919 4 +Actin based cell projection 0.3004685505133208 0.2356255046720786 0.8137232807499508 1.0 1.0 47 Q9Y6M7,Q13509,P21281,Q9UQB8 4 +Cell surface 0.2886726957795141 0.2355449980760383 0.8137857576919854 1.0 1.0 75 P08183,O96005,P00390,Q12955,P42892,Q4VCS5,Q13685,Q8WTV0,P05067,Q13641,Q4KMQ2 11 +Ribose phosphate diphosphokinase complex 0.573699900629359 0.2317526501890879 0.8167301354784426 1.0 1.0 2 O60256 1 +Terminal bouton 0.362852404643446 0.214652939508775 0.8300379160733007 1.0 1.0 6 Q05682,Q7L576,O14617,P27708,P11142 5 +Eukaryotic translation initiation factor 2b complex 0.3623198182107748 0.2131992599443537 0.8311715454776665 1.0 1.0 6 Q9NR50,Q14232,Q13144,P49770 4 +Endoribonuclease complex 0.3275274544997271 0.2129130007829278 0.8313948217169624 1.0 1.0 11 Q9UPY3,Q15631 2 +Esc e z complex 0.5414083385561645 0.1900541976993477 0.8492666607846402 1.0 1.0 3 Q15022 1 +Proteasome regulatory particle base subcomplex 0.3425157650182617 0.1888729093980628 0.8501924265735281 1.0 1.0 8 P62191,P35998,Q99460,P17980,P43686,Q13200,P62333 7 +Brisc complex 0.5380248058143566 0.184355040241538 0.853734937921121 1.0 1.0 3 Q15018 1 +Microtubule end 0.3162917303770784 0.1703879801587092 0.8647050243683694 1.0 1.0 10 Q7Z460,Q15018 2 +Cd95 death inducing signaling complex 0.5359390526664588 0.1643736002637639 0.8694370448239233 1.0 1.0 2 P49327 1 +Death inducing signaling complex 0.5359390526664588 0.1643736002637639 0.8694370448239233 1.0 1.0 2 P49327 1 +Alpha dna polymerase primase complex 0.3927742790851717 0.1537496044263681 0.877807171071372 1.0 1.0 4 P09884,P49643,P25205 3 +Trans golgi network membrane 0.2887444240193788 0.1532700170828418 0.8781853441762324 1.0 1.0 22 P40616,P05067,P20645,Q15334 4 +Retromer complex 0.3182449854896159 0.1524674064771932 0.8788182957215174 1.0 1.0 9 O60749,Q9UNH7,Q9UBQ0 3 +Cul5 ring ubiquitin ligase complex 0.5250082808877246 0.1481450129628434 0.8822283261385708 1.0 1.0 2 Q93034 1 +Cul4 ring e3 ubiquitin ligase complex 0.3415119363395209 0.1377264125746074 0.8904566441053969 1.0 1.0 5 Q92990,Q9Y4B6,Q13620,P61962 4 +Ap type membrane coat adaptor complex 0.3049068211680452 0.1367166819859299 0.8912547430332636 1.0 1.0 11 Q92572,P56377,Q96CW1 3 +Dynactin complex 0.3346209761500036 0.1247057332566948 0.9007565183550864 1.0 1.0 5 Q9UJW0,O75935,P61163 3 +Stereocilium bundle 0.3175926874303223 0.1226764063783005 0.9023633477044876 1.0 1.0 8 Q9Y6M7 1 +Rnai effector complex 0.3158643263741221 0.105195262497157 0.9162208698458956 1.0 1.0 6 Q9UPY3,P26196 2 +Nurd complex 0.2988047808764944 0.1008889997139977 0.9196385755075897 1.0 1.0 9 Q13330,Q92769,Q13547,Q86YP4,O95983,Q8WXI9,Q9BTC8,O94776 8 +Sodium potassium exchanging atpase complex 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 1.0 3 P05026 1 +Atpase dependent transmembrane transport complex 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 1.0 3 P05026 1 +Cation transporting atpase complex 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 1.0 3 P05026 1 +Phagocytic cup 0.3080832377637195 0.0908733219225949 0.9275932484859122 1.0 1.0 6 Q15642 1 +Cortical actin cytoskeleton 0.277105530659173 0.0865049227945986 0.9310650429190552 1.0 1.0 31 P63167,Q15334,Q9Y5X1 3 +Dopaminergic synapse 0.4595758780649381 0.0860321378342746 0.9314408696308354 1.0 1.0 3 O75955,P20337 2 +Inclusion body 0.2708059278059027 0.0856119329260847 0.9317749121868644 1.0 1.0 23 Q9H0D6,P35573,P28340,P13807,P42858 5 +Mitochondrial protein containing complex 0.3438717551561154 0.0826468528575502 0.9341323454879502 1.0 1.0 153 P21796,Q99595,Q9Y6M9,P14406,Q8N4H5,P00846,O75964,Q9NS69,Q96CU9,O60830,Q86Y39,P03886,P00403,O14925,Q9Y512,O14949,Q9UDW1,Q9BPX6,Q567V2 19 +Postsynaptic cytoskeleton 0.4633984763166771 0.0823891832295741 0.9343372373393124 1.0 1.0 2 P07196 1 +Parallel fiber to purkinje cell synapse 0.4633984763166771 0.0823891832295741 0.9343372373393124 1.0 1.0 2 P23634 1 +Paranodal junction 0.4633984763166753 0.0823891832295728 0.9343372373393136 1.0 1.0 2 Q8IXJ6 1 +Large ribosomal subunit 0.2738983140975992 0.0777426566961446 0.9380327616296508 1.0 1.0 78 Q9Y3U8,P83881,P39023,P46776,P27635,P18621,Q02543,Q16540,P62917,P83731,Q9BYC9,P46779,Q02878,P61313,P46778,P18077,Q9BRJ2,Q567V2,Q9NWU5,Q14197 20 +Myelin sheath adaxonal region 0.4531301755548358 0.0752323567505889 0.9400298403305232 1.0 1.0 2 P09543 1 +Schmidt lanterman incisure 0.4531301755548316 0.0752323567505861 0.9400298403305254 1.0 1.0 2 Q8IXJ6 1 +Neuron to neuron synapse 0.2598255945100462 0.0726236814340982 0.942105581417499 1.0 1.0 59 Q9BY67,Q15334,Q9UQB8,P62917,Q9NQC3,Q99720 6 +Anchored component of synaptic vesicle membrane 0.2970822281167103 0.067525563933081 0.9461633113912956 1.0 1.0 5 Q15286,P20337,P20339,P61020 4 +Septin cytoskeleton 0.2952589262982491 0.065323056751693 0.947916784914356 1.0 1.0 5 Q9NVA2,Q15019 2 +Elongator holoenzyme complex 0.4257786613651373 0.0618973709319188 0.9506445611777384 1.0 1.0 3 Q9H9T3,Q6IA86 2 +Sperm head 0.4247846255798486 0.0613277109197853 0.9510982222100046 1.0 1.0 3 P25685,P08238 2 +Endoplasmic reticulum plasma membrane contact site 0.4163630341172719 0.0566562430393555 0.9548190309882234 1.0 1.0 2 A0FGR8 1 +Secondary lysosome 0.3749585955614539 0.045713294447204 0.9635387674509316 1.0 1.0 2 P13473 1 +Autolysosome 0.3749585955614539 0.045713294447204 0.9635387674509316 1.0 1.0 2 P13473 1 +Cell cortex region 0.2694052373061673 0.0450651649650204 0.9640553675298248 1.0 1.0 10 Q7Z460,Q13363 2 +Cytoplasmic side of endosome membrane 0.3623716462404864 0.043819102519333 0.9650486000999136 1.0 1.0 2 Q9UL25 1 +Early phagosome 0.3624917163684517 0.0381195710333733 0.969592347221628 1.0 1.0 3 O60493,Q13636 2 +Myosin filament 0.3545394300861448 0.0365529751679351 0.9708414388293998 1.0 1.0 3 P35580,P35579 2 +Ficolin 1 rich granule 0.2767190013873918 0.0342786747435335 0.9726549299639335 1.0 1.0 86 P63167,P10253,P09960,Q93050,P16278,P42785,P20618,P08236,P09429,P15586,Q13510 11 +Rna polymerase iii complex 0.275107722903538 0.0331675328424117 0.9735409889086092 1.0 1.0 4 O14802,Q9BUI4,P62875 3 +Anaphase promoting complex 0.262256576793535 0.0305715121218925 0.975611261559736 1.0 1.0 10 P30260,Q13042 2 +Neurofilament 0.293744222509994 0.0304238790971112 0.9757290009027956 1.0 1.0 3 O14786 1 +Cd40 receptor complex 0.2779986746189472 0.0298725792211019 0.976168674698048 1.0 1.0 3 O14920,O15111 2 +Rough endoplasmic reticulum membrane 0.2556828876800147 0.0183260186693919 0.985378771053423 1.0 1.0 10 Q9Y5M8,P49458 2 +T tubule 0.2568510212175576 0.0128770129149893 0.9897259141437952 1.0 1.0 8 Q12955,P05026,P35241,P23634 4 +Photoreceptor connecting cilium 0.2191644562334231 0.0122457434862652 0.9902295545304908 1.0 1.0 5 Q15814,P36405,Q15555,Q15019 4 +Presynapse 0.273348172965641 0.0078368825787553 0.9937471363907228 1.0 1.0 86 Q13363,Q9Y296,P56545,Q15334,Q13641,P42858,Q96CW1,P05067,Q92542,Q9UQB8,O75150,Q99808,P50897,Q92905,Q96A57,Q96CX2,O43760,Q15286,Q9BT78 19 +Neuron spine 0.25907740305239 0.0066526038625674 0.994692029241548 1.0 1.0 30 Q15334,P05067,Q9UQB8 3 +Nuclear pore nuclear basket 0.233952549018694 0.0057511542227485 0.9954112681348636 1.0 1.0 6 Q13257 1 +Organelle subcompartment 0.4294352631118613 0.0051327570242594 0.9959046703980414 1.0 1.0 321 P30519,P24390,P09601,Q9Y5X1,Q9NZ01,Q14108,Q99720,O00461,Q9Y282,Q9HD20,Q96G23,Q9Y5P4,O75844,Q15629,Q8IV08,P67812,P07099,Q8TB61,Q9GZP9,Q15800,O60725,O15260,Q9NZ08,P04062,Q96N66,Q15392,O00443,Q86XL3,Q16850,Q9BRR6,Q7Z3C6,Q8N4V1,Q86YN1,P16435,O43826,P05067,Q9NQC3,O43865,O95070,P43307,Q969V3,Q9NPR9,O00560,Q14534,P20645,O95197,Q96GC9,O95470,Q15042,Q15334,Q14739,P49257,O95864,P49458,O14579,Q2TAA5,P35613,Q99943,P57088,Q15436,O75915,A1L0T0,Q6NUM9,A8CG34,P40616,P37287,Q9Y296,Q9BUN8,P38435,Q9BXS5,Q8N2K0,P48739,P15291,Q9UBU6,O94966,P63241,Q6PIU2,P51648,P48651 79 +9plus0 non motile cilium 0.2488445197404586 0.0006622164290392 0.9994716277739776 1.0 1.0 11 P35613,Q96FJ2,Q15019,P46821 4 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..50fd3439d8b87820046d1ac68f4ca1d3d0fa5c1c --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Cbm complex", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Glycosylphosphatidylinositol n acetylglucosaminyltransferase gpi gnt complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi trans cisterna", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Picln sm protein complex", "Pigment granule", "Pinosome", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquinone biosynthesis complex", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATG3", "ATG9A", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPTF", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "C12orf43", "C12orf57", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "C3orf58", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CASK", "CAST", "CBL", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC134", "CCDC47", "CCDC58", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CMPK1", "CNN3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COA7", "COASY", "COG1", "COG3", "COG8", "COIL", "COL4A3BP", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM162A", "FAM208A", "FAM210B", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOSR1", "GOT2", "GPAA1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPF1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "IST1", "ISY1", "ITCH", "ITGB1", "ITPRIP", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRIG2", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METTL13", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NENF", "NEO1", "NES", "NFS1", "NFU1", "NGDN", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIPSNAP3A", "NISCH", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX5", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF5A", "PHF6", "PHF8", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PVR", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF9B", "TAMM41", "TAP1", "TARDBP", "TARS2", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFIP11", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM14C", "TMEM167A", "TMEM192", "TMEM201", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", 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sha256:afb0c0f7de367abea645e61e38cc615257ab5fc8ef2cc1f4bffa3a4a36cc243a +size 134566 diff --git a/msigdb_gomf/basic/plot_8.png b/msigdb_gomf/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..380138d65c6408fbf0e7f3aa9ab24ad592c6b851 --- /dev/null +++ b/msigdb_gomf/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b112536a298f492c88988b1df07b6ec4250f9c55bb35de70de3a708b9ad02e02 +size 142452 diff --git a/msigdb_gomf/basic/plot_9.png b/msigdb_gomf/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..63d47422d0b64797dbf39162dc480c96a6ca2d89 --- /dev/null +++ b/msigdb_gomf/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3f1cec0183c3a774771255574e1aec0fdb94f7ace8b2a19bd1822d3fe3530634 +size 145004 diff --git a/msigdb_gomf/consensus.joblib b/msigdb_gomf/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..bb25b363bcb92e83fdfa90c84fb0575beed92202 --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5431e12b189c87058a787302b1f4d6c4f027ca5378f4a675aeab726c21055c0d +size 150530 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d5581b035dc8bfe4938cdd3ddf0f8b4c19104aab --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,58 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Serine hydrolase activity 6 20 2.9327227782695795 0.0033600376484157 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.0010588512016649 0.0014597322722839 0.0011293669878184 0.0001454175845293 8.622528396165615e-05 +Phospholipid binding 15 83 2.8464892114611247 0.00442042270522 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.0002404341697939 0.0004840916096804 0.002434837242897 0.0028848968821005 0.0394906849408023 +Tetrapyrrole binding 4 17 2.7704533382290784 0.0055978320296634 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0216431235145122 0.0265864003984115 0.0149914480702132 0.0098040194800285 0.0468997373757593 +Steroid binding 5 18 2.7603452573594107 0.0057740304551552 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 0.00112460538858 7.841716015047822e-05 0.0012207780133745 0.0011347755104788 0.0023530303459661 +Exopeptidase activity 9 34 2.734775282468376 0.0062422875144516 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 0.0021209704035119 0.0029102285656399 2.4490692503129386e-05 1.4820531230257533e-05 0.0001532274543384 +Anion transmembrane transporter activity 14 46 2.7161615569744364 0.0066043681390064 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.0986286025003162 0.1184945425124205 0.033005107755267 0.0117127861395935 0.000406183398384 +Protein transporter activity 4 15 2.674449549164601 0.0074852037678048 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0001506402477847 0.0002094223372061 8.694316847855437e-05 0.0002915955446555 0.0064224361124591 +Sterol binding 3 13 2.674231835127608 0.0074900652435128 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 0.0004527686618606 2.280160421415856e-05 0.0003733671894444 0.0109251570181746 0.0294030506330725 +Cholesterol binding 3 10 2.6600140718558687 0.0078137386849568 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0002620337797635 1.0830323879735215e-05 0.0001815434943904 0.0056932223374956 0.0564014374232863 +Quaternary ammonium group binding 2 12 2.65695800664539 0.0078849264159917 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0001017571546353 0.0001416199496639 0.0011613234829685 0.0155574138143109 0.0035916782285116 +Inorganic molecular entity transmembrane transporter activity 18 71 2.6552223285216563 0.0079256153182567 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 0.2734622109779442 0.1059878394856559 0.0845825617565572 0.0008695350730573 0.0155299885874391 +Ion transmembrane transporter activity 27 95 2.6280723545233915 0.0085870248925632 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 0.3776661931280964 0.1785882769281409 0.00983012928708 0.0001996090854275 0.0005795920681848 +Serine type exopeptidase activity 4 7 2.586173237155846 0.0097048140163726 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 5.766879702741373e-06 8.064461453409737e-06 6.936272072908627e-05 9.515842072742196e-07 2.915330495677531e-05 +Amide binding 18 92 2.581137736872481 0.0098475283502259 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 0.0016536343469851 0.0027115167180276 0.0001566716265794 6.042008056195669e-07 2.319846969199795e-05 +Peptide binding 9 63 2.565101336012686 0.0103145675866487 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.1273005556271761 0.1519896688943138 0.0529971691837449 0.0031129413237264 0.0275610661694587 +Structural constituent of cytoskeleton 6 32 2.551576003405227 0.0107236932007497 9.25242718446602 32.0873786407767 -0.0188268562209467 0.5866618916343601 4.554883108071276 3.199231692100145 0.95009639129484 0.328822437643629 0.0002546738391414 0.0003907011914147 6.493581403491033e-06 0.0020809493840137 0.0096395482179569 +Endopeptidase activity 22 61 2.49768983726309 0.0125005513482179 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 1.0 1.0 0.0756746726427118 0.0002020221247156 0.0001663595058542 +Alcohol binding 3 14 2.4789253726001808 0.0131778874628862 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.001192887389514 8.49425410120894e-05 0.0013172485850202 0.0328601744798646 0.2267695434684957 +Serine type carboxypeptidase activity 3 5 2.472024425025229 0.0134350336761328 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 6.946721228631906e-07 9.728697370677428e-07 8.49211205937994e-06 1.6763230163867931e-06 2.7039815749173976e-05 +Phosphatidylcholine binding 2 7 2.4662225152521167 0.013654647982279 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 3.766158290874906e-05 5.253086721125362e-05 0.000440337804097 0.0062969264366488 0.0063986173037271 +Protein transmembrane transporter activity 3 11 2.457366638761457 0.0139959765113251 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 4.559753324496552e-05 6.357667188483331e-05 0.0005309775927247 0.0006333985816127 0.0080495273899022 +Modified amino acid binding 2 21 2.4474078828398915 0.0143887900977428 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 0.0010588512016649 0.0014597322722839 0.0108939889611676 0.1109177218711893 0.0835081281085846 +Hydrolase activity acting on glycosyl bonds 11 28 2.4216373605573533 0.0154507605162443 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.2662696416305189 0.2922756805728106 0.0052630916622981 9.774905195498091e-06 4.492868172016964e-05 +Inorganic anion transmembrane transporter activity 7 20 2.4185250710688084 0.0155835716359502 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0201615592452014 0.0247821522094747 0.0890100643743446 0.001554887013827 0.0008270207644745 +Monooxygenase activity 4 6 2.403686443863259 0.0162306881267224 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0057036049754646 0.0070670490819082 0.0021303683071518 0.0004258249435971 0.009006759688013 +Macromolecule transmembrane transporter activity 3 12 2.3842311475701714 0.0171148485460137 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 7.577115353961114e-05 0.0001055314719321 0.0008717411361388 0.0012174977382918 0.0022923961599421 +Ceramide binding 4 5 2.3748179915037766 0.0175576054378414 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 0.0013157873870524 0.0016377422378922 0.0002296483500821 8.971938182982207e-06 0.0002528551610256 +Cation transmembrane transporter activity 16 64 2.367579330952063 0.0179048810220996 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 1.0 0.6679820446196049 0.1820864285977347 0.0042293294780357 0.0599346502527403 +Voltage gated channel activity 2 8 2.3514097689306537 0.0187024250191572 3.2257281553398056 10.116504854368932 0.8578192560085278 0.2690365421745596 1.8168622808181427 1.411127559025233 1.234834479111217 0.2694186191218866 0.0089475442467942 0.0110614955842043 0.0420348553288257 0.0489147892655661 0.229933672353323 +Molecular transducer activity 8 30 2.3505817754149003 0.0187440884397334 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.0944432774245011 0.0326606433793201 0.1025723617341366 0.2920300824031097 0.7217625828548933 +Exogenous protein binding 2 14 2.33520001536489 0.0195329743435321 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0153347588201295 0.0012094933792174 0.0091243340822671 0.0958173315210673 0.1758221500942633 +Carboxypeptidase activity 4 12 2.3089552022433395 0.0209460672499428 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 0.0001329537382921 0.0001849020150097 0.0015052123544451 0.0024740226177806 0.005348590970678 +Arp2 3 complex binding 0 5 2.295400280477548 0.0217101953002354 2.075242718446602 4.567961165048544 -0.325431456514568 0.5462178385194748 1.460372571600779 1.2178856094540027 0.8548147580344945 0.3072790462925835 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.2559514735144251 0.451869757084416 +Sulfur compound transmembrane transporter activity 2 7 2.277907151286454 0.0227321101208743 2.9635922330097086 6.752427184466019 1.4746434057995097 0.1672652154050841 1.7026919602194592 1.5538455059459366 1.0954441166028872 0.2266277553273111 1.0 1.0 0.031373049189738 0.0326106125072858 0.1665994534041104 +Oxidoreductase activity acting on the ch nh group of donors 0 10 2.268994261715674 0.0232686748266963 3.1601941747572817 10.305825242718448 0.0551009250515943 0.5304967852483793 2.7312588159267728 1.103245454360311 0.9214732780943902 0.2958894860869119 0.0850069130381694 0.0944323477659319 0.1837383274168749 0.4040612158985918 0.6509887274409705 +Sphingolipid binding 4 7 2.239049389479969 0.0251527027552975 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0025466683159972 0.0031646532309382 0.0006327439593496 5.4054011518008696e-05 0.0013736729067174 +Oxidoreductase activity acting on a heme group of donors 2 6 2.228155968283473 0.0258701161477228 3.111650485436894 6.483009708737864 0.8850005512180296 0.2757097651603665 1.538237610319269 1.0226572421183926 1.2777814224392188 0.2966482201944345 1.0 1.0 1.0 0.050241067872642 0.0339846578092061 +Cargo receptor activity 2 6 2.227781262906579 0.0258951049208744 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.0061259837897953 0.0075879492488378 0.0023694947377154 0.029757296929711 0.0454470617698533 +Gated channel activity 3 11 2.209653995848133 0.0271291848137342 4.317961165048544 13.019417475728156 0.8697524591818097 0.2583579989367679 2.2914716766946497 2.0107989163575497 1.3733766112751231 0.2762671399351702 0.0263487782631664 0.0323055044295255 0.1132051672598368 0.1789420187780838 0.3366922318797414 +O acyltransferase activity 2 11 2.195252756700615 0.0281454717642086 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.1266743042911767 0.1403531442218371 0.0376249374527164 0.0419909810254146 0.0686432790956221 +Hydrolase activity hydrolyzing o glycosyl compounds 9 21 2.18300952015113 0.0290351089356466 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 0.1839914155887378 0.2031027035797352 0.0108939889611676 1.7797131365174685e-05 1.4724035658487924e-05 +Voltage gated anion channel activity 2 5 2.170845213004084 0.0299428749200743 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 0.0007652325753279 0.0009534063593398 0.0039135152062846 0.0015031185668187 0.0107435842434709 +Protein phosphatase activator activity 0 5 2.1470290658333626 0.0317909677109733 1.6699029126213591 4.320388349514563 0.1442671946673689 0.5055297529461918 1.197800164172842 1.269229505844015 1.0058385089501891 0.3109555467889161 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.2559514735144251 0.451869757084416 +Phosphatase activator activity 0 5 2.1470290658333626 0.0317909677109733 1.827669902912621 5.038834951456311 0.2237572035576459 0.4866812214382258 1.3004522767274551 1.5083735862416845 1.015613648009018 0.3076019667715845 0.0693787843053731 0.0771453392642774 0.1515272625734178 0.3422564852890665 0.5734281396877692 +Organic cation transmembrane transporter activity 2 5 2.1432095737118195 0.0320962738869736 1.9271844660194175 5.04126213592233 1.6158747778246996 0.14183106997637 1.275055237696066 0.9168044752551467 0.8418646651592007 0.1871331589544055 1.0 1.0 0.1265462710440741 0.0442367692127036 0.0281854945142632 +Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor 0 9 2.134047307548356 0.0328389085129914 3.3155339805825244 9.1747572815534 -0.0822659283487201 0.520789618970474 2.835703617469018 1.0397645781526508 0.9371302185048814 0.2942319480110578 0.0654311950523822 0.0727733471903131 0.1432798584585485 0.3258327648280404 0.5514871371697274 +Threonine type peptidase activity 4 7 2.117372091843419 0.0342282808333131 3.8106796116504857 8.762135922330097 1.392634148189787 0.2146040118876429 1.6274593113109357 0.6695334565847216 1.0340073360925757 0.2572219198248905 1.0 1.0 0.1265462710440741 0.0002821754852333 0.0003776201815095 +Threonine type endopeptidase activity 4 7 2.117372091843419 0.0342282808333131 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.0 0.0921025797166938 6.393058955734768e-05 5.5966724052351854e-05 +Phosphoric diester hydrolase activity 1 9 2.106723732798549 0.0351415337728451 2.029126213592233 10.385922330097088 0.7290228511785473 0.4081342737861556 1.4528599895098884 1.5700769487624953 0.8628601700755856 0.2801596524830074 0.1874490790789025 0.2068720246493716 0.0803922289273931 0.3354134477865137 0.6984217718540238 +Thiolester hydrolase activity 6 16 2.0926789318656684 0.0363778251927402 3.5388349514563107 15.259708737864075 0.4632661556505638 0.4260334035866009 2.4217755265330267 1.4839032472520584 1.039719510457206 0.2990167148437984 1.0 1.0 0.0354914601129098 0.0064140084647031 0.0034148471359396 +Anion channel activity 3 11 2.090653654697859 0.0365591222934782 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 0.0061259837897953 0.0075879492488378 0.0293903981750984 0.029757296929711 0.0454470617698533 +Nadph binding 1 5 2.0530820980674043 0.0400646158724231 1.3786407766990292 5.429611650485437 0.8367704566864596 0.3914568233833007 1.0938176207501296 1.2950229014206938 0.8806674554162238 0.2962147259816868 0.0574868878492186 0.0639684350193291 0.1265462710440741 0.2917500038862815 0.1472320281277068 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 8 28 2.03008014650188 0.0423483932322088 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0583885127423368 0.0708561744170628 0.0601458293215769 0.0074315744767491 0.0374462035731319 +Phospholipid transporter activity 5 9 2.0058288503887973 0.0448745114220301 2.1771844660194173 6.699029126213592 0.5736831867868913 0.3651436001806147 1.523334307555052 1.8451455672114891 1.0803825413008894 0.2760174807519195 1.0 1.0 0.2802926639431586 0.0012777259352904 0.0055117318404591 +1 phosphatidylinositol binding 1 6 2.005826391258828 0.0448747738821957 0.9296116504854368 5.730582524271845 0.5854159685461776 0.452723274314548 1.2912689794694188 0.5192756815806097 0.8614060502856912 0.2874504674264635 0.0015309811904185 0.0019049706229129 0.0077184558590264 0.0442367692127036 0.1472320281277068 +Pdz domain binding 3 14 1.970817234061506 0.0487447847090867 3.9271844660194177 14.419902912621358 0.5491111169746481 0.4670646684125319 2.189901543859342 2.754676868666853 0.9064591556484958 0.2972085908111159 0.1908924307713893 0.2106238865638343 0.0832345551471358 0.1214587331941242 0.2267695434684957 +Organic acid transmembrane transporter activity 5 21 1.961980698529008 0.0497647314576568 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 1.0 1.0 0.4825947600252522 0.2292149669309593 0.1138343131961507 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c7eda48c04b47dd7339542086f612085c3b472f0 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 1370, + "title": "Average number of proteins per term", + "value": 16.103649635036497 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..725249422582ddd3e495ecd00f5391167169c51b --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0677ff2abb719390e287de3124ec2da9c296bc0b --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,421 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine hydrolase activity 0.7629243467386848 2.9327227782695795 0.0033600376484157 0.990058153338674 0.2553909852637105 20 Q9H3G5,P67812,Q9HB40,P42785,O14773,P10619 6 +Phospholipid binding 0.5523147245942355 2.8464892114611247 0.00442042270522 0.9976874481704406 0.2553909852637105 83 O00443,P21796,P07602,P45880,P50897,O14773,Q9Y5X1,Q8NCC3,P30086,Q14108,Q8WTV0,Q9Y4G8,O00560,Q9BWH2,Q9Y5P4 15 +Tetrapyrrole binding 0.7742046303088539 2.7704533382290784 0.0055978320296634 0.9995428848794548 0.2553909852637105 17 P30519,P09601,O43169,Q16850 4 +Steroid binding 0.7591969445911262 2.7603452573594107 0.0057740304551552 0.9996414159669722 0.2553909852637105 18 P21796,P45880,P04062,O15118,Q14108 5 +Exopeptidase activity 0.6458318424049554 2.7347752824683753 0.0062422875144516 0.9998119377083012 0.2553909852637105 34 Q9NZ08,Q9H3G5,Q9HB40,Q9UIQ6,P42785,Q969V3,O14773,P10619,O75844 9 +Anion transmembrane transporter activity 0.5991268004297315 2.7161615569744364 0.0066043681390064 0.999885849712455 0.2553909852637105 46 Q14728,P21796,P45880,Q9UBX3,Q9Y6M7,Q8TB61,Q9H2D1,Q9BQT8,O43826,Q96NB2,Q9C0H2,P53985,O43681,Q4KMQ2 14 +Protein transporter activity 0.7791817124235471 2.6744495491646014 0.0074852037678048 0.99996614084477 0.2553909852637105 15 Q99595,O60830,Q9HD20,Q9NS69 4 +Sterol binding 0.8073434912562156 2.674231835127608 0.0074900652435128 0.9999663672948794 0.2553909852637105 13 Q14108,P21796,P45880 3 +Cholesterol binding 0.8442706454832234 2.6600140718558687 0.0078137386849568 0.9999784872222036 0.2553909852637105 10 Q14108,P21796,P45880 3 +Quaternary ammonium group binding 0.8172860026822728 2.65695800664539 0.0078849264159917 0.9999805012901196 0.2553909852637105 12 P21796,P45880 2 +Inorganic molecular entity transmembrane transporter activity 0.5185235851690212 2.6552223285216563 0.0079256153182567 0.9999815666720814 0.2553909852637105 71 Q96ES6,P21796,P45880,Q8N4V1,Q9UBX3,Q9Y6M7,Q93050,O14548,P00403,P21281,O43826,Q9C0H2,Q9HD20,Q9Y487,P00846,O75964,Q4KMQ2,Q9UDW1 18 +Ion transmembrane transporter activity 0.54249425077752 2.6280723545233915 0.0085870248925632 0.999992607355018 0.2553909852637105 95 Q14728,P21796,P45880,Q9UBX3,O14548,Q9C0H2,Q9Y487,P53985,P00846,O75964,Q96ES6,Q8N4V1,P00403,Q9BQT8,O43826,Q96NB2,Q9HD20,Q70HW3,O43681,Q93050,Q8TB61,Q9H2D1,Q4KMQ2,Q9UDW1,Q9Y6M7,P21281,O43772 27 +Serine type exopeptidase activity 0.935462347339507 2.586173237155846 0.0097048140163726 0.9999984238593284 0.2553909852637105 7 Q9HB40,P42785,O14773,P10619 4 +Amide binding 0.5344383975587779 2.581137736872481 0.0098475283502259 0.9999987062689716 0.2553909852637105 92 P00374,Q9NZ08,P21796,P07602,P45880,P24390,Q96AY3,Q9NZJ7,Q9UIQ6,P42892,O14773,Q6UX04,Q13356,Q8WTV0,Q15392,Q02252,P49748,Q9Y5P4 18 +Peptide binding 0.499710063104284 2.565101336012686 0.0103145675866487 0.9999993221501228 0.2611307336873945 63 Q9NZ08,P24390,Q9UIQ6,P42892,O14773,Q6UX04,Q13356,Q8WTV0,Q15392 9 +Structural constituent of cytoskeleton 0.6237517122832579 2.551576003405227 0.0107236932007497 0.9999996152995154 0.2611307336873945 32 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Endopeptidase activity 0.4904150919887757 2.49768983726309 0.0125005513482179 0.99999996722817 0.2762218604364284 61 P49720,Q96K76,P55210,P60900,P28070,Q86UV5,P20618,Q92542,P49721,O75844,P67812,Q8TCT9,Q5JRX3,Q9Y4E8,Q9H300,Q9NZ08,P28074,P42892,Q16740,O14773,P51784,P52888 22 +Alcohol binding 0.7535266326340712 2.4789253726001808 0.0131778874628862 0.9999999871986625 0.2771066432628603 14 Q14108,P21796,P45880 3 +Serine type carboxypeptidase activity 0.9490367508257924 2.4720244250252295 0.0134350336761328 0.9999999910423456 0.2771066432628603 5 Q9HB40,P42785,P10619 3 +Phosphatidylcholine binding 0.9054268811407682 2.4662225152521167 0.013654647982279 0.9999999933971222 0.2771066432628603 7 P21796,P45880 2 +Protein transmembrane transporter activity 0.7872211263253718 2.4573666387614574 0.0139959765113251 0.9999999958903828 0.2771066432628603 11 Q99595,O60830,Q9NS69 3 +Modified amino acid binding 0.6627097347165911 2.4474078828398915 0.0143887900977428 0.9999999976192212 0.2771066432628603 21 Q14108,P00374 2 +Hydrolase activity acting on glycosyl bonds 0.611550700550781 2.4216373605573533 0.0154507605162443 0.9999999994563816 0.2771066432628603 28 P10253,O60502,P04062,P16278,P04066,P54802,O75503,Q9NUJ1,P08236,O43598,Q9Y223 11 +Inorganic anion transmembrane transporter activity 0.6709161918618687 2.4185250710688084 0.0155835716359502 0.9999999995481146 0.2771066432628603 20 P21796,P45880,Q9UBX3,Q9Y6M7,O43826,Q9C0H2,Q4KMQ2 7 +Monooxygenase activity 0.8959466084395845 2.403686443863259 0.0162306881267224 0.9999999998164388 0.2779505341701221 6 Q15800,P30519,P09601,Q16850 4 +Macromolecule transmembrane transporter activity 0.7595271570791282 2.3842311475701714 0.0171148485460137 0.999999999946445 0.2853266795826085 12 Q99595,O60830,Q9NS69 3 +Ceramide binding 0.9240716180371432 2.3748179915037766 0.0175576054378414 0.9999999999711118 0.2853266795826085 5 Q9Y5P4,P07602,P21796,P45880 4 +Cation transmembrane transporter activity 0.4809097766553238 2.367579330952063 0.0179048810220996 0.999999999982202 0.2853266795826085 64 Q96ES6,Q8N4V1,Q9Y6M7,Q93050,O14548,P00403,P21281,Q96NB2,O43772,Q9HD20,Q9Y487,P00846,O75964,Q4KMQ2,Q9UDW1,Q70HW3 16 +Voltage gated channel activity 0.842013168915565 2.3514097689306537 0.0187024250191572 0.9999999999941522 0.2853266795826085 8 P21796,P45880 2 +Molecular transducer activity 0.5980206100610225 2.3505817754149003 0.0187440884397334 0.9999999999944826 0.2853266795826085 30 Q15629,P20645,O15118,Q99720,Q14108,P10586,Q8WTV0,O15173 8 +Exogenous protein binding 0.7247930554511627 2.33520001536489 0.0195329743435321 0.9999999999981668 0.2864241927056088 14 Q14108,Q8WTV0 2 +Carboxypeptidase activity 0.743917693414446 2.3089552022433395 0.0209460672499428 0.999999999999746 0.2880092931914632 12 Q9HB40,P42785,Q9H3G5,P10619 4 +Sulfur compound transmembrane transporter activity 0.8591284624007649 2.277907151286454 0.0227321101208743 0.9999999999999792 0.2880092931914632 7 Q70HW3,Q8TB61 2 +Sphingolipid binding 0.8497003410012492 2.2390493894799692 0.0251527027552975 0.9999999999999992 0.2908381157687003 7 Q9Y5P4,P07602,P21796,P45880 4 +Oxidoreductase activity acting on a heme group of donors 0.8527522215504124 2.2281559682834735 0.0258701161477228 0.9999999999999998 0.2908381157687003 6 P00403,P16435 2 +Cargo receptor activity 0.8526609340883897 2.227781262906579 0.0258951049208744 0.9999999999999998 0.2908381157687003 6 Q14108,Q8WTV0 2 +Gated channel activity 0.7348407211256707 2.209653995848133 0.0271291848137342 1.0 0.2997337354420641 11 P21796,P45880,Q4KMQ2 3 +O acyltransferase activity 0.7318420876818705 2.195252756700615 0.0281454717642086 1.0 0.308474370535727 11 P23786,Q8NCC3 2 +Hydrolase activity hydrolyzing o glycosyl compounds 0.6185748758194203 2.18300952015113 0.0290351089356466 1.0 0.3132133798569756 21 P10253,O60502,P04062,P16278,P04066,P54802,Q9NUJ1,P08236,Q9Y223 9 +Voltage gated anion channel activity 0.8725630246650127 2.1708452130040836 0.0299428749200743 1.0 0.3204823331289202 5 P21796,P45880 2 +Organic cation transmembrane transporter activity 0.865671605185723 2.1432095737118195 0.0320962738869736 1.0 0.3331204183723782 5 Q70HW3,O43772 2 +Threonine type peptidase activity 0.8204426325088174 2.117372091843419 0.0342282808333131 1.0 0.347353664752882 7 P20618,P28070,P49720,P49721 4 +Threonine type endopeptidase activity 0.8204426325088174 2.117372091843419 0.0342282808333131 1.0 0.347353664752882 7 P20618,P28070,P49720,P49721 4 +Phosphoric diester hydrolase activity 0.7526356064366276 2.1067237327985495 0.0351415337728451 1.0 0.3539992740352781 9 P09601 1 +Porin activity 0.940392357563118 2.095861531619454 0.0360944760523147 1.0 0.3546409090831927 4 P21796 1 +Wide pore channel activity 0.940392357563118 2.095861531619454 0.0360944760523147 1.0 0.3546409090831927 4 P21796 1 +Thiolester hydrolase activity 0.6567358985505495 2.0926789318656684 0.0363778251927402 1.0 0.3546409090831927 16 P50897,Q8N2K0,Q16775,Q9NUJ1,Q9NUQ7,O00154 6 +Anion channel activity 0.7102091875895545 2.090653654697859 0.0365591222934782 1.0 0.3546409090831927 11 P21796,P45880,Q4KMQ2 3 +Nadph binding 0.8433341253302549 2.0530820980674043 0.0400646158724231 1.0 0.3759487927754776 5 P00374 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.5540228467956234 2.03008014650188 0.0423483932322088 1.0 0.3920087751900413 28 P30519,Q14534,Q8NB78,P09601,P16435,Q15800,Q16850,O95864 8 +Phospholipid transporter activity 0.7305841274026602 2.0058288503887973 0.0448745114220301 1.0 0.4071419882027031 9 P08183,Q96GC9,Q4KMQ2,Q9Y5P4,Q7Z3C6 5 +1 phosphatidylinositol binding 0.7992370957838013 2.005826391258828 0.0448747738821957 1.0 0.4071419882027031 6 Q9Y5X1 1 +Pdz domain binding 0.6540658003462188 1.970817234061506 0.0487447847090867 1.0 0.4268552373764921 14 Q9UQB8,Q9Y4G8,Q9BY67 3 +Organic acid transmembrane transporter activity 0.5826559235258287 1.961980698529008 0.0497647314576568 1.0 0.4268552373764921 21 P08183,Q9UBX3,Q9H2D1,Q9BQT8,P53985 5 +Palmitoyl protein hydrolase activity 0.8152212474598752 1.9384821259922829 0.0525644294165885 1.0 0.4297252830136179 5 Q9NUJ1 1 +Nadp binding 0.6193655071033339 1.936955802253825 0.0527507462929532 1.0 0.4297252830136179 17 P00374,P00390,Q14739,P16435 4 +Vitamin transmembrane transporter activity 0.8145704113646182 1.9358139983606184 0.0528904858256296 1.0 0.4297252830136179 5 Q9H2D1,P04062 2 +Intramembrane lipid transporter activity 0.7824108568036537 1.9348402092793004 0.0530099071746725 1.0 0.4297252830136179 6 P08183,Q4KMQ2,Q7Z3C6 3 +G protein alpha subunit binding 0.8070319659251561 1.904861390787972 0.0567980911842602 1.0 0.440717275236848 5 P80303 1 +Long chain acyl coa dehydrogenase activity 0.8891334936891315 1.8998091516751217 0.0574581695099385 1.0 0.440717275236848 4 Q9NZ01 1 +Transporter activity 0.5263117222153463 1.8821545668435824 0.0598150323169437 1.0 0.440717275236848 160 P08183,Q14728,P21796,P45880,Q9UBX3,Q99595,Q9Y6M9,O14548,Q8WTV0,Q9C0H2,Q9Y487,P53985,P00846,O75964,O15173,Q9NS69,Q7Z3C6,Q96ES6,Q9BSK2,O60830,Q8N4V1,O15118,P03886,P00403,Q9BQT8,O43826,Q96NB2,Q9HD20,Q70HW3,O43681,Q9Y5P4,O14925,Q8IXU6,Q93050,Q8TB61,Q9H2D1,Q4KMQ2,Q9UDW1,P04062,Q9Y6M7,Q96GC9,P21281,O43772 43 +Acylglycerol o acyltransferase activity 0.769563080088614 1.8803030190146053 0.060066792091413 1.0 0.440717275236848 6 Q8NCC3,Q96N66 2 +Dynein intermediate chain binding 0.7264043710834401 1.8467446262149656 0.0647841606581351 1.0 0.4586809897603145 8 P63167,Q8NCM8,P43034,P42858,P62826 5 +Lipid transporter activity 0.5938647890164062 1.8435863659626055 0.0652434444925993 1.0 0.4586809897603145 18 P08183,Q96GC9,P48739,O15118,P22059,Q96SU4,Q4KMQ2,Q9Y5P4,Q7Z3C6 9 +Hydrolase activity acting on ether bonds 0.7603452538390834 1.8410003059826885 0.0656215138635194 1.0 0.4586809897603145 6 P07099,O43865 2 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 0.7800361944888609 1.7933068224822513 0.0729238771016862 1.0 0.4929939047450274 5 Q9UQ84 1 +Protein arginine n methyltransferase activity 0.7489220563847525 1.792098030335376 0.073117264360643 1.0 0.4929939047450274 6 Q99873,Q6P2P2,Q7L592,Q86X55,O60678 5 +Four way junction dna binding 0.7728779840848806 1.7635480570290951 0.0778080995141605 1.0 0.4981172725906541 5 P09429,P26583,O15347,P52701 4 +Heparin binding 0.6213436359807918 1.7442848920493936 0.0811094247338213 1.0 0.5168367994666754 13 P47914,O14737,O14786,O43670,Q13685,P10586,P05067,P35268,P43034 9 +Peptidase activity 0.4714731491035883 1.737043392315978 0.0823795119663488 1.0 0.5200918497414652 113 Q9H3G5,P09960,P49720,P02786,Q96KP4,Q96K76,P42785,P10619,Q93009,P55210,O95630,Q96FW1,P60900,P28070,Q7Z2K6,Q9HB40,O00487,Q86UV5,P07384,P20618,P55786,P49721,Q92542,O94966,O75844,P67812,Q92905,Q9UIQ6,Q969V3,Q8TCT9,Q5JRX3,Q9NUQ7,Q9Y4E8,Q9H300,Q9NZ08,Q9HBH5,Q8IYS1,P28074,P42892,Q16740,O14773,P51784,Q92890,P52888,Q9BT78 45 +Phosphatidylserine binding 0.646906696290396 1.7322402961087957 0.0832307871545805 1.0 0.5218988196405184 10 Q14108 1 +Organic anion transmembrane transporter activity 0.5060886141907625 1.7086087240780337 0.0875234515758427 1.0 0.5262689523092899 31 Q14728,Q9UBX3,Q9Y6M7,Q8TB61,Q9H2D1,Q9BQT8,Q96NB2,P53985 8 +Guanyl nucleotide exchange factor activity 0.5083487002585341 1.704192578644644 0.0883451152288781 1.0 0.5262689523092899 27 Q9NR50,P29692,Q92538,Q9H8V3,Q15042,Q02818,P80303,Q9NPQ8,Q13144,Q9HAD4,Q9Y4G8,P49770,Q9P258 13 +Omega peptidase activity 0.5203330831818106 1.7036738405983276 0.0884420379048138 1.0 0.5262689523092899 23 O95630,Q96FW1,Q9HBH5,Q86UV5,Q96K76,Q92890,P51784,Q93009,O94966,Q9Y4E8 10 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9963564094070884 1.7009111707539326 0.0889596686751463 1.0 0.5262689523092899 2 P30519 1 +Ubiquitin like modifier activating enzyme activity 0.7275526756901377 1.700058098886973 0.089119997763325 1.0 0.5262689523092899 6 Q9UBE0 1 +Lipid binding 0.4804236678208177 1.6668628863595782 0.0955416721814086 1.0 0.5431207090810366 130 O00443,P21796,P45880,Q9Y5X1,Q8NCC3,Q14108,A6NIH7,Q8WTV0,Q9Y4G8,O15173,P28070,O15118,P30086,Q9Y5P4,P50897,O00560,P07602,P04062,O14773,Q9BWH2 20 +Copper ion binding 0.6861397436703757 1.6647437685071216 0.0959638868129768 1.0 0.5432666319577615 8 P00403,O60888 2 +Solute cation symporter activity 0.7178619187339139 1.658092183407012 0.0972988613712679 1.0 0.547889430413768 6 Q9Y6M7 1 +Acyltransferase activity 0.4379657224904074 1.6324049711619444 0.1025942026009594 1.0 0.5577541966798191 54 Q9BWD1,O14929,Q09472,Q96N66,Q8NCC3,Q9NPF4,P23786,Q15102,Q96G23 9 +Phospholipase d activity 0.9774759854256384 1.6260656372587612 0.1039356930613291 1.0 0.5591015097644159 2 P09601 1 +5 3 exodeoxyribonuclease activity 0.9774759854256376 1.6260656372587592 0.1039356930613295 1.0 0.5591015097644159 2 Q9UQ84 1 +Symporter activity 0.6748549922704745 1.6132307823956704 0.1066943781075215 1.0 0.5672289981988482 8 Q9Y6M7,Q96ES6 2 +Lysophosphatidic acid binding 0.9645578005962244 1.5747952883181284 0.11530370434638 1.0 0.5942493517400433 2 P50897 1 +Passive transmembrane transporter activity 0.4866073090810303 1.5717965912766818 0.1159977323403278 1.0 0.5942493517400433 32 P21796,P45880,P00846,O75964,Q4KMQ2 5 +Metalloendopeptidase activity 0.579189034840782 1.569307833915326 0.1165762278084989 1.0 0.5942493517400433 14 Q5JRX3,P42892,O75844 3 +Sulfotransferase activity 0.9582643259357404 1.5498069084979356 0.1211878683763387 1.0 0.6047096593558052 2 Q8NCH0 1 +Sterol transporter activity 0.7195412246064603 1.5397306433666684 0.1236260240883941 1.0 0.6047096593558052 5 P22059,O15118 2 +Cytokine activity 0.7188441157969173 1.5367840087631466 0.1243462106752 1.0 0.6047096593558052 5 P09429,P43490 2 +Active ion transmembrane transporter activity 0.4669395445157773 1.512673668898011 0.1303625711644171 1.0 0.6223121744676983 40 Q96ES6,Q9Y6M7,P21281,P00403,O43826,Q9HD20,Q9UDW1 7 +Transforming growth factor beta receptor binding 0.78750207975102 1.5022065098328976 0.1330437841316341 1.0 0.6223121744676983 4 Q96AC1,Q9Y4E8 2 +Epoxide hydrolase activity 0.7872171857029493 1.5010794434259005 0.13333501500595 1.0 0.6223121744676983 4 P07099 1 +Ether hydrolase activity 0.7872171857029493 1.5010794434259005 0.13333501500595 1.0 0.6223121744676983 4 P07099 1 +Transition metal ion transmembrane transporter activity 0.9453461411063282 1.4985071875486269 0.1340015266189569 1.0 0.6223121744676983 2 Q9HD20 1 +Palmitoyl coa hydrolase activity 0.6795049752368206 1.4907646949134907 0.1360232839774346 1.0 0.6246807732263696 6 O00154,P50897 2 +Single stranded dna exodeoxyribonuclease activity 0.7072821400397986 1.4878463833946154 0.1367914101955554 1.0 0.6246807732263696 5 Q9UQ84 1 +Cytoskeletal anchor activity 0.6634706578284882 1.4387144927874438 0.1502314314113206 1.0 0.638518724269739 7 Q12955,O00560,Q9UQB8 3 +Signal recognition particle binding 0.6663780755119623 1.433120677122503 0.1518233532952735 1.0 0.638518724269739 6 Q9GZP9,P49458 2 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.5539919137754776 1.4310737440684485 0.1524090812854539 1.0 0.6385334598197917 14 Q9UPY3,Q9UQ84,Q9BRJ7,Q96F86 4 +Metalloexopeptidase activity 0.489222692591685 1.4249627331321877 0.1541679739357144 1.0 0.6407985272973368 22 Q9NZ08,P09960,P02786,Q96KP4,Q9UIQ6,Q969V3,O75844 7 +Ganglioside binding 0.9231533620404108 1.410414559759432 0.158417308713969 1.0 0.6454699591796104 2 P07602 1 +Clathrin binding 0.5351260498172528 1.4103122081105706 0.1584475153196742 1.0 0.6454699591796104 16 Q5VW38,Q9BXS5,O00443 3 +Lipopolysaccharide binding 0.6543497210766397 1.3982129666158858 0.1620491241140853 1.0 0.6497712576157497 7 Q8WTV0,P28070 2 +Phosphatidylinositol phosphate kinase activity 0.9198410069559472 1.3972772958812931 0.1623302005346001 1.0 0.6497712576157497 2 O00443 1 +Scavenger receptor activity 0.936194066464336 1.394159226961752 0.1632695273378195 1.0 0.6497712576157497 3 Q14108 1 +5 3 exonuclease activity 0.5791566762136471 1.392971105757217 0.1636285283776888 1.0 0.6497712576157497 10 Q9UQ84 1 +Exodeoxyribonuclease activity 0.5997355135705706 1.3864722844032065 0.1656027375946469 1.0 0.6509331580284365 9 Q9UQ84 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.5542042017854222 1.3860116341433657 0.1657433510072516 1.0 0.6509331580284365 13 Q9UPY3,Q9UQ84,Q9BRJ7,Q96F86 4 +Aldo keto reductase nadp activity 0.5988854260904108 1.3823559730627577 0.1668624274085046 1.0 0.6512863975773544 9 Q9BTZ2,P35270,Q9HBH5 3 +Pre mirna binding 0.7553861451773254 1.374908324691558 0.1691598680885246 1.0 0.653043664389066 4 Q9UPY3,Q9H2U1,P62826 3 +Mhc protein binding 0.5973311731193532 1.3748279463464297 0.1691847918656699 1.0 0.653043664389066 9 P68371 1 +Frizzled binding 0.909903941702551 1.35789319045991 0.1744975784417608 1.0 0.6656190563856494 2 O00560 1 +Phosphatidylinositol binding 0.4227952729701686 1.3559538455987332 0.1751138536047103 1.0 0.6656190563856494 50 O60749,O00443,P48739,Q9Y5X1,P07737,Q6IBS0,P22059,Q13045,Q8WTV0,Q9Y5P4,Q15286,Q96AC1,O00560,Q9BWH2,Q9UNH7,Q9Y4P8 16 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.9254473161033836 1.3553437879571375 0.1753080500497945 1.0 0.6656190563856494 3 Q15800,Q16850 2 +Phospholipid scramblase activity 0.9231278992710412 1.346969408594468 0.1779900853653013 1.0 0.6656190563856494 3 Q4KMQ2,Q7Z3C6 2 +Sulfatide binding 0.9211432820254648 1.3398049140930843 0.1803087776200183 1.0 0.6656190563856494 3 P50897 1 +Dynein light intermediate chain binding 0.6719625029551597 1.3377408915941085 0.1809809160877784 1.0 0.6656190563856494 5 P63167,Q8NCM8 2 +Polyubiquitin modification dependent protein binding 0.5599571537952089 1.3330593514224638 0.1825123274553928 1.0 0.6656190563856494 11 P46379,Q15018,P35573,Q96P47 4 +Mhc class i protein binding 0.6131129454469011 1.3283014768199826 0.1840785320680964 1.0 0.6656190563856494 8 P68371 1 +Metal ion transmembrane transporter activity 0.4996270365221152 1.326104861491414 0.1848049660750876 1.0 0.6656190563856494 19 Q9Y6M7,Q9HD20 2 +Structural constituent of muscle 0.7422533244506786 1.3227642130657895 0.1859138017284092 1.0 0.6656190563856494 4 P60660 1 +Abc type transporter activity 0.635235754611388 1.3131292245362027 0.189139407705877 1.0 0.6656190563856494 7 Q9HD20 1 +Lipid transfer activity 0.7397871394393125 1.3129704169317429 0.1891929168291026 1.0 0.6656190563856494 4 P48739,Q9Y5P4 2 +Sulfuric ester hydrolase activity 0.896654521364691 1.305466113464843 0.1917341786598549 1.0 0.6656190563856494 2 P15586 1 +Dna insertion or deletion binding 0.7372622099570528 1.3029433139465871 0.1925941149879828 1.0 0.6656190563856494 4 P12004,P52701 2 +Mismatched dna binding 0.7372622099570528 1.3029433139465871 0.1925941149879828 1.0 0.6656190563856494 4 P12004,P52701 2 +Organophosphate ester transmembrane transporter activity 0.5301995602103768 1.29948300198898 0.1937782231651088 1.0 0.6656190563856494 14 Q9BSK2,O43826,Q8TB61,Q9H2D1 4 +Phosphatase regulator activity 0.4953410953606835 1.2994458028655784 0.1937909815663736 1.0 0.6656190563856494 19 Q13362 1 +Protein phosphatase regulator activity 0.5024696980589729 1.2981583334416873 0.1942329326354477 1.0 0.6656190563856494 18 Q13362 1 +3 5 dna helicase activity 0.6059430498768734 1.2949670880316215 0.1953315832977655 1.0 0.6656190563856494 8 P49736,P46063,P33992,P19447,Q14566 5 +Ubiquitin like protein specific protease activity 0.4499271918351524 1.2908070372995109 0.1967705969607212 1.0 0.6656190563856494 31 O95630,Q96FW1,Q9HBH5,Q86UV5,Q96K76,Q92905,Q92890,Q9NUQ7,P51784,Q93009,O94966,Q9Y4E8,Q9BT78 13 +Aspartic type peptidase activity 0.7305270135896548 1.2761980205063417 0.2018855282183997 1.0 0.6737678220076044 4 Q92542,Q8TCT9,P55210 3 +Lys48 specific deubiquitinase activity 0.6573126062085327 1.275317193190113 0.2021969946378941 1.0 0.6737678220076044 5 O94966,Q9Y4E8 2 +Oxidized dna binding 0.6564089271835291 1.2714654385255115 0.2035631153297012 1.0 0.6752577917716484 5 P43246,P52701 2 +G rich strand telomeric dna binding 0.6283032520260414 1.2652125588378735 0.2057951416547592 1.0 0.6780181498772625 6 P22626,Q15554,P15927 3 +Proteoglycan binding 0.8990367222899358 1.2600947185264135 0.2076351952999484 1.0 0.6780181498772625 3 O00560 1 +Nadplus adp ribosyltransferase activity 0.6482095490716127 1.2365167457488098 0.2162665450663015 1.0 0.6949878388760672 5 Q9UGN5,Q7Z2W4,Q9ULX3,Q8IXJ6 4 +Transcription coregulator binding 0.4429732411202579 1.232645077741619 0.217708211059719 1.0 0.6949878388760672 26 Q15648,Q13363,Q09472,Q15022,P49711,P56545,P51784,Q9NZN8,Q9UQB8 9 +Secondary active transmembrane transporter activity 0.4586802565881068 1.2194319797303212 0.2226802782226258 1.0 0.701314899229879 22 Q9Y6M7,Q96ES6,O43826,Q9UBX3 4 +P type transmembrane transporter activity 0.6420625433274004 1.210320065947038 0.2261561008647863 1.0 0.7088971927600201 5 P05026,P23634,P16615 3 +Cyclin dependent protein serine threonine kinase regulator activity 0.7129058281111851 1.2062687891737265 0.2277138677847612 1.0 0.7088971927600201 4 P11802,P14635 2 +Phosphatidylinositol bisphosphate phosphatase activity 0.7126284388465312 1.2051688424788352 0.2281381278960825 1.0 0.7088971927600201 4 Q01968,Q9Y217,Q8WUK0 3 +Organic hydroxy compound transmembrane transporter activity 0.8832254835687001 1.203241533238106 0.2288828668675615 1.0 0.7088971927600201 3 Q14728 1 +Phosphatidylinositol 3 kinase activity 0.8675057966214013 1.1906489863815308 0.2337914122815316 1.0 0.7124365823735512 2 O00443 1 +1 phosphatidylinositol 3 kinase activity 0.8675057966214013 1.1906489863815308 0.2337914122815316 1.0 0.7124365823735512 2 O00443 1 +Growth factor receptor binding 0.4907943458167546 1.187892725282705 0.2348756761356345 1.0 0.7124365823735512 17 Q9NZ08,P05067,Q92542,O00560 4 +Cyclin dependent protein kinase activity 0.5802956863516742 1.1755566848626984 0.2397720730711898 1.0 0.7172221399727732 8 P11802,Q00534 2 +Vitamin d binding 0.8628684995031506 1.172471606450725 0.2410077652286695 1.0 0.7193477959984254 2 P04062 1 +Gtpase activity 0.3946703030977109 1.1596768803820516 0.2461803865766911 1.0 0.7221936424134591 91 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Dynactin binding 0.6294413658139808 1.1565666777471322 0.2474494429831975 1.0 0.7221936424134591 5 P43034,P42858 2 +Phospholipid transfer activity 0.858562437893347 1.1556194353679985 0.2478368547354907 1.0 0.7221936424134591 2 Q9Y5P4 1 +Sphingolipid transfer activity 0.858562437893347 1.1556194353679985 0.2478368547354907 1.0 0.7221936424134591 2 Q9Y5P4 1 +Phosphatidylcholine transporter activity 0.8585624378933461 1.1556194353679952 0.2478368547354921 1.0 0.7221936424134591 2 P08183 1 +Glycolipid binding 0.550691656784895 1.1481398879312996 0.2509108199184613 1.0 0.7221936424134591 9 P07602,O14773,P50897 3 +Active transmembrane transporter activity 0.3696928205956084 1.1444278582601866 0.2524462404062531 1.0 0.7221936424134591 69 P08183,Q96ES6,Q9UBX3,Q9Y6M7,Q9Y6M9,O14548,P00403,P03886,O43826,P21281,Q9HD20,Q9UDW1 12 +Inorganic anion exchanger activity 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.7221936424134591 2 Q9Y6M7 1 +Phosphatidylinositol phosphate phosphatase activity 0.6255471082956992 1.1399961198652455 0.2542879176537633 1.0 0.7221936424134591 5 Q01968,Q9Y217,Q8WUK0 3 +Dna directed dna polymerase activity 0.5995671524802386 1.1382500801313158 0.2550160723059393 1.0 0.7221936424134591 6 Q07864,Q9NRF9,P28340 3 +Ion gated channel activity 0.8621295132371029 1.1276999366186078 0.2594466644452087 1.0 0.7221936424134591 3 Q4KMQ2 1 +Intracellular calcium activated chloride channel activity 0.8621295132371029 1.1276999366186078 0.2594466644452087 1.0 0.7221936424134591 3 Q4KMQ2 1 +Proton transmembrane transporter activity 0.4252218103355515 1.1233129145707332 0.2613046208045695 1.0 0.7221936424134591 35 Q96ES6,Q93050,O14548,P00403,P21281,P00846,O75964,Q9UDW1 8 +Cytokine receptor binding 0.4669395589693685 1.1222281241721863 0.2617654575766863 1.0 0.7221936424134591 19 Q96J02,Q9NZ08,P14174,P30046,P48681,O43776,Q9Y4E8,Q96AC1,O00560,P62993,Q9UNH7 11 +Metallopeptidase activity 0.4136439844488721 1.1200879556088137 0.2626762826785453 1.0 0.7221936424134591 43 Q9NZ08,P09960,Q96KP4,Q9UIQ6,Q969V3,P42892,Q5JRX3,P52888,O75844 9 +Mannose binding 0.594620100764449 1.1164168750138137 0.264243733492884 1.0 0.7221936424134591 6 O75503,P49257 2 +Sphingolipid transporter activity 0.8588469184890845 1.1159862185277416 0.2644280337867166 1.0 0.7221936424134591 3 P08183,Q9Y5P4 2 +Dna polymerase activity 0.5408689150784536 1.1003438639993492 0.2711823271857347 1.0 0.7299013521502095 9 Q9NRF9,P28340,Q15185,Q07864,Q15554 5 +Dicarboxylic acid transmembrane transporter activity 0.5638566717985162 1.0990227568133422 0.2717581398731015 1.0 0.7300169639728413 8 Q9UBX3 1 +Serine type endopeptidase inhibitor activity 0.6131342165762379 1.087249887656741 0.2769263887563074 1.0 0.7326325354272004 5 P30086 1 +D threo aldose 1 dehydrogenase activity 0.6800897154644399 1.0765043398717011 0.2817017610207877 1.0 0.7352635765881701 4 P48507 1 +Protein arginine omega n asymmetric methyltransferase activity 0.8469184890656065 1.0735318227780477 0.2830325684760555 1.0 0.7356056164462792 3 O60678,Q99873 2 +Carbon sulfur lyase activity 0.5833588936066162 1.0667805429562645 0.2860709466737119 1.0 0.7356056164462792 6 Q6YP21,P32929,P53701 3 +Lysophospholipid acyltransferase activity 0.6065370128451784 1.059274290943955 0.2894748798614608 1.0 0.7356056164462792 5 Q96N66 1 +Pentosyltransferase activity 0.4746848057208187 1.0591810034458502 0.2895173547543259 1.0 0.7356056164462792 16 Q13126 1 +Protein methyltransferase activity 0.4188758366588548 1.0542233961347127 0.2917806509053737 1.0 0.7375267375283432 28 Q99873,Q15022,Q86X55,O60725,Q52LJ0,O60678,Q9H7B4 7 +Transmembrane transporter binding 0.4171203310111716 1.044653227904205 0.2961832692087536 1.0 0.7432130787272362 26 P21796,P42858 2 +Cyclosporin a binding 0.4971156205752425 1.0397336068130243 0.2984636824853539 1.0 0.7432130787272362 12 Q6UX04 1 +Acyl coa dehydrogenase activity 0.5255289818242386 1.0258146413647942 0.30497896335136 1.0 0.7474439710042275 9 Q9NZ01 1 +Nucleobase containing compound transmembrane transporter activity 0.4734511769707163 1.023381843509277 0.3061273405984077 1.0 0.7486740744737032 15 Q9BSK2,Q99808,Q8TB61,Q9H2D1,P51991 5 +Nucleotide transmembrane transporter activity 0.4854774136894471 1.0127909791224126 0.3111600104388801 1.0 0.7565703206006673 13 Q9BSK2,Q8TB61,Q9H2D1 3 +Type i transforming growth factor beta receptor binding 0.8214640609473354 1.0117730850276718 0.3116465617428119 1.0 0.7565703206006673 2 Q96AC1 1 +Coa hydrolase activity 0.5449048070797692 1.0110004234752892 0.3120162271090343 1.0 0.7565703206006673 8 O00154,P50897 2 +Protein arginine omega n monomethyltransferase activity 0.8267064280980815 1.0020665921970071 0.3163114316491588 1.0 0.763393266834074 3 O60678,Q99873 2 +Proline rich region binding 0.5929127528028811 1.001672621408887 0.3165017339866818 1.0 0.763393266834074 5 Q9UQB8 1 +Glucosidase activity 0.5905576224653365 0.9917435505588416 0.3213226406736704 1.0 0.772301785478822 5 P10253 1 +Nadp retinol dehydrogenase activity 0.5652674900356558 0.9873200152846768 0.3234857815347043 1.0 0.7761392656787126 6 Q9BTZ2 1 +Aspartic endopeptidase activity intramembrane cleaving 0.8135144087446196 0.981335909004916 0.3264271202810067 1.0 0.778531283222428 2 Q8TCT9 1 +Nucleoside triphosphatase regulator activity 0.3555540192623699 0.9797880639426854 0.3271907451802278 1.0 0.778531283222428 70 P63167,Q92538,Q9P2J5,Q15042,Q01968,Q15334,Q9Y4G8,Q9H8V3,P49770,Q9NPQ8,Q9NR50,P29692,Q9P258,O14786,Q9H6Z4,P55010,Q9Y2L1,P80303,Q13144,Q13576,Q02818,Q68EM7,Q92974,P52565,Q96P47,Q15436,Q9HAD4,Q66K14 28 +Rage receptor binding 0.8108645246770481 0.9712266557017888 0.3314354228527501 1.0 0.7801830400485698 2 P09429 1 +Acetylcholine receptor binding 0.8029148724743331 0.9410160811477316 0.3466966182923872 1.0 0.8024966401737723 2 Q15334 1 +Ubiquitin specific protease binding 0.5516023442111336 0.9408684631274876 0.3467722707904184 1.0 0.8024966401737723 7 P46379 1 +Actin monomer binding 0.6425674656240837 0.9297554713847545 0.3524977062895544 1.0 0.8069621436337089 4 P07737,Q6IBS0 2 +Phosphatidylinositol bisphosphate binding 0.456719006204476 0.9282594369210924 0.3532730096651404 1.0 0.8069621436337089 15 Q92538,Q6IBS0,P07737,O60493,Q13045,Q15286,O00560,Q9Y4P8 8 +Gdp dissociation inhibitor activity 0.5754016230746841 0.9280936011336536 0.353359018574527 1.0 0.8069621436337089 5 P55010 1 +Glutathione disulfide oxidoreductase activity 0.8055296539362413 0.9279874541240424 0.3534140775038141 1.0 0.8069621436337089 3 P78417 1 +Acid amino acid ligase activity 0.5734258250461803 0.9198315388055248 0.3576607992553786 1.0 0.8088892718195139 5 P48507 1 +Signal sequence binding 0.4065562314526456 0.9184446158131708 0.3583861418808642 1.0 0.8088892718195139 23 P50542,A8CG34,P24390 3 +Alcohol dehydrogenase nadpplus activity 0.5244880629444696 0.9167054078978792 0.3592970315166668 1.0 0.8096002190424894 8 Q9BTZ2,Q9HBH5 2 +Phosphatidylinositol phosphate binding 0.3994663760759337 0.9101781327833106 0.3627285744280617 1.0 0.8119904362196807 31 Q92538,P07737,Q6IBS0,P22059,Q13045,Q9Y5P4,O60493,Q15286,Q96AC1,O00560,Q9BWH2,P35080,Q9Y4P8 13 +Cullin family protein binding 0.631807355900323 0.8881869082525412 0.3744402197700642 1.0 0.8247473679246965 4 Q96GG9 1 +Transferase activity transferring alkyl or aryl other than methyl groups 0.4403930315508418 0.8881736597323729 0.3744473451453731 1.0 0.8247473679246965 17 P78417,P49366 2 +Nuclear export signal receptor activity 0.5168050609067869 0.8814376759190644 0.3780809730643355 1.0 0.8287534929570235 8 P55060,Q9UIA9,P62826 3 +Nedd8 specific protease activity 0.7895957587806607 0.8729161371887145 0.3827087898195622 1.0 0.8307950365928561 3 Q92905,Q96FW1 2 +Isopeptidase activity 0.4751016516190239 0.8647401844465985 0.3871814083201819 1.0 0.8307950365928561 10 O95630,P51665,Q7L5N1,O00487,Q92905,O15372 6 +Fatty acid derivative binding 0.4744213994981566 0.861327644509766 0.3890576142557433 1.0 0.8307950365928561 10 O00154,Q02252,Q9H845,P49748 4 +Acyl coa binding 0.4744213994981566 0.861327644509766 0.3890576142557433 1.0 0.8307950365928561 10 O00154,Q02252,Q9H845,P49748 4 +Acetyltransferase activity 0.3923805466163506 0.8580777701432353 0.3908495214050118 1.0 0.8327587003497142 32 Q9BWD1,O14929,Q15102 3 +Lys63 specific deubiquitinase activity 0.7750910897648264 0.8368669502012759 0.4026673594690499 1.0 0.8417468148496952 2 O95630 1 +Hexosaminidase activity 0.5533967841230361 0.8366524985629687 0.4027879269349348 1.0 0.8417468148496952 5 O60502 1 +Phosphatidylinositol 4 5 bisphosphate binding 0.464109442760471 0.8361768690525985 0.4030554091543066 1.0 0.8417468148496952 11 Q6IBS0,P07737,Q13045,Q15286,O00560 5 +Atpase coupled transmembrane transporter activity 0.4145468302044622 0.8329043726587443 0.4048986633697127 1.0 0.8443092371636323 20 Q9HD20,P21281 2 +Ubiquitin protein transferase inhibitor activity 0.5251376172694975 0.8249396495569132 0.4094058544920249 1.0 0.8488742619325697 7 Q92990,P62913,P62841,P62829,P46777 5 +Oxidoreductase activity acting on a sulfur group of donors 0.3862186252834051 0.8171661616247986 0.4138334774023575 1.0 0.849074475812442 27 P00390,P78417,Q6DKJ4,Q9UHG3 4 +Mismatch repair complex binding 0.7723658051689868 0.8141427290368194 0.4155631899499423 1.0 0.8497336869125687 3 P12004,P52701 2 +Mutlalpha complex binding 0.7723658051689868 0.8141427290368194 0.4155631899499423 1.0 0.8497336869125687 3 P12004,P52701 2 +Cytokine binding 0.5384439596060159 0.7753829369320108 0.4381134146856511 1.0 0.874949530786213 5 P09429,O14786 2 +Thyroid hormone receptor binding 0.4521122041140124 0.750316557706478 0.4530640726378752 1.0 0.8866041453356118 10 Q15648 1 +Transcription coactivator binding 0.5096573307224228 0.7475184383916477 0.4547506770984886 1.0 0.8866041453356118 6 Q15648 1 +H4 histone acetyltransferase activity 0.5945141274302412 0.7467659845866434 0.4552048316222676 1.0 0.8866041453356118 4 O14929 1 +Amino acid transmembrane transporter activity 0.4512237197687118 0.7459380764586538 0.4557048226479705 1.0 0.8866041453356118 10 Q9H936,Q9UPY5,Q96NB2,Q9Y619,O75746 5 +Atpase coupled cation transmembrane transporter activity 0.4352149335853431 0.7426900476846618 0.4576693565575782 1.0 0.8866041453356118 13 Q9HD20 1 +Enzyme activator activity 0.3633585954631471 0.741420197468339 0.4584387018990115 1.0 0.8866041453356118 99 P63167,P07602,Q15436,Q13362,Q9NZJ7,Q15042,Q5JRX3,Q15334,P05067,Q68EM7,Q9Y4G8,P10619,Q66K14,Q9UBE0,O43169 15 +Histone arginine n methyltransferase activity 0.7481776010603195 0.7332689498540345 0.4633944090436115 1.0 0.8866041453356118 3 Q86X55,Q99873 2 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.4835366502524418 0.7308217860554068 0.4648880146128071 1.0 0.8866041453356118 8 P11802,Q00534 2 +G quadruplex rna binding 0.7409738323948377 0.713401218977109 0.4755975190167072 1.0 0.886933152464587 2 Q9H2U1 1 +Carboxylic ester hydrolase activity 0.3717970278197889 0.7121903697313466 0.4763468995753701 1.0 0.886933152464587 36 Q9NUJ1,P35790,Q15165,Q8NCC3 4 +Phosphatidylinositol 3 5 bisphosphate phosphatase activity 0.7403113613779455 0.7110593464894064 0.4770474607399122 1.0 0.886933152464587 2 Q9Y217 1 +Amidine lyase activity 0.7399801258694985 0.7098892832568134 0.4777727966083143 1.0 0.886933152464587 2 O75223 1 +Metal dependent deubiquitinase activity 0.4982046977818599 0.7092759550608064 0.4781532467285627 1.0 0.886933152464587 7 P51665,Q7L5N1,O00487,Q92905,O15372 5 +Voltage gated chloride channel activity 0.7369990062934821 0.6993851864744172 0.4843113429385484 1.0 0.8930101478140124 2 Q4KMQ2 1 +Phosphate ion binding 0.5183568435247312 0.6945157749441496 0.4873588114420357 1.0 0.8974214673058992 5 Q8NCH0 1 +Adrenergic receptor binding 0.5760733517230464 0.6788215817454257 0.4972509174948432 1.0 0.9107403168020524 4 Q9Y4G8 1 +Signaling receptor regulator activity 0.404162278372543 0.6541412550768718 0.5130208044987965 1.0 0.918743140082812 16 P09429,Q12904,P05067,P43490 4 +Ribonuclease p rna binding 0.718798492605347 0.6381939138012691 0.5233474585611786 1.0 0.9266143936220376 3 O95707 1 +Fad binding 0.4285361786854322 0.6355890153788771 0.5250443309606472 1.0 0.9266143936220376 10 Q8NB78,Q15392 2 +Phosphoric ester hydrolase activity 0.3164416394171791 0.6308331706339776 0.5281496121544551 1.0 0.9266143936220376 60 Q96T60,Q9Y3Z3,Q9Y217,Q8IV08,P09601,Q9NPH0,P10586,Q8WUK0 8 +Phosphatidylinositol kinase activity 0.5611265494165653 0.6249862099371022 0.5319801088571978 1.0 0.9266143936220376 4 O00443 1 +Protein carrier chaperone 0.4785228439446919 0.6185674076693415 0.5362013784408013 1.0 0.9266143936220376 6 Q5J8M3,Q8N4V1 2 +Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity 0.7123923127899292 0.6180006663803131 0.5365748993493646 1.0 0.9266143936220376 3 Q01968,Q8WUK0 2 +Phosphatidylinositol 4 5 bisphosphate phosphatase activity 0.7123923127899292 0.6180006663803131 0.5365748993493646 1.0 0.9266143936220376 3 Q01968,Q8WUK0 2 +Phosphatidylinositol phosphate 5 phosphatase activity 0.7123923127899292 0.6180006663803131 0.5365748993493646 1.0 0.9266143936220376 3 Q01968,Q8WUK0 2 +Metalloaminopeptidase activity 0.4108858404967487 0.6157940912029248 0.5380304276875374 1.0 0.9266143936220376 13 Q9UIQ6 1 +Phosphatidylinositol trisphosphate phosphatase activity 0.7121563431599927 0.6138475924567881 0.539316044302548 1.0 0.9266143936220376 2 Q01968 1 +Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity 0.7121563431599927 0.6138475924567881 0.539316044302548 1.0 0.9266143936220376 2 Q01968 1 +Inositol polyphosphate 5 phosphatase activity 0.7121563431599927 0.6138475924567881 0.539316044302548 1.0 0.9266143936220376 2 Q01968 1 +Inositol trisphosphate phosphatase activity 0.7121563431599927 0.6138475924567881 0.539316044302548 1.0 0.9266143936220376 2 Q01968 1 +Protease binding 0.3538245120568291 0.6042555354112631 0.5456737635040425 1.0 0.933245092324731 24 P46379,P07602,Q9NZJ7,Q9GZP9,Q96RR1 5 +Histone h3 methyl lysine 4 demethylase activity 0.5549989470896184 0.6032790921222458 0.5463230394484921 1.0 0.933245092324731 4 Q8NB78 1 +Primary active transmembrane transporter activity 0.3446060770731455 0.5909367875734427 0.5545627760095997 1.0 0.9430702357723436 47 P08183,Q9Y6M9,P03886,P21281,Q9HD20,Q9UDW1 6 +Chemoattractant activity 0.7027833001988224 0.5881153360473407 0.5564548799771489 1.0 0.9430702357723436 3 P09429,P26583 2 +Membrane insertase activity 0.489649831623921 0.5826798392401847 0.5601088475943776 1.0 0.9430702357723436 5 Q5J8M3,Q8N4V1 2 +Antiporter activity 0.4085111876655573 0.5802895158944776 0.5617193962849654 1.0 0.9430702357723436 12 Q9UBX3,O43826,P04920,P12236 4 +Protein phosphatase 2a binding 0.4305457543307073 0.5780826842353662 0.563208297028593 1.0 0.9430702357723436 9 Q86XL3,Q8NFC6 2 +Phosphotransferase activity for other substituted phosphate groups 0.487741492580287 0.5754329268305653 0.5649985407350597 1.0 0.9430702357723436 5 Q9NRN7 1 +Deoxyribonuclease activity 0.3808404329243587 0.566810940354577 0.5708426368264667 1.0 0.944928916283226 18 Q9UQ84 1 +Ubiquitin conjugating enzyme binding 0.4630263204746713 0.563661555623815 0.5729844858127866 1.0 0.944928916283226 7 Q96GG9,Q9BTE7 2 +Scaffold protein binding 0.3657862368992788 0.562629460018434 0.5736872270695026 1.0 0.944928916283226 21 Q15334,P07602,Q9NZJ7,Q9UQB8 4 +Translation regulator activity nucleic acid binding 0.3076747014295248 0.5625232116042175 0.5737595934955275 1.0 0.944928916283226 62 Q9NR50,P00374,P29692,P41214,Q05639,Q9ULC4,Q14197,O75821,P55010,Q92905,P46199,Q13144,P63241,P49770,Q9Y262 15 +Microtubule plus end binding 0.4445016731763914 0.5609108983802114 0.5748582801117539 1.0 0.944928916283226 8 Q7Z460 1 +Carbohydrate derivative transmembrane transporter activity 0.4066947396208971 0.550839281889929 0.5817438533524428 1.0 0.9482568872074258 11 O43826,Q8TB61 2 +Long chain fatty acid binding 0.6916197416363103 0.5461733896369089 0.5849467560587671 1.0 0.9482568872074258 2 P52758 1 +Transcription corepressor binding 0.3923448513261905 0.5452727660725734 0.5855659318083812 1.0 0.9482568872074258 14 Q13363,Q15022,P56545,P51784,Q9NZN8 5 +Retromer complex binding 0.5352257878660218 0.5348641141385208 0.5927438246715235 1.0 0.9547923889659042 4 O60493,P20645 2 +N acyltransferase activity 0.3617314030592671 0.5074364637170815 0.6118486062485364 1.0 0.9668195969555882 20 O14929,Q96G23 2 +Lamin binding 0.4306407344033708 0.5031737316395252 0.6148421316298571 1.0 0.9694760002142484 8 Q5SNT2,Q14739,O94901 3 +Glycosyltransferase activity 0.328302017521388 0.496977635284472 0.619204822664511 1.0 0.9694760002142484 50 Q9H974,Q13126,P37287,P43490,P35573,P04062,Q9UGN5,P46976,P15291,Q9BT22,P13807,Q6ZXV5,Q16880,Q16739,Q2TAA5 15 +Aminopeptidase activity 0.3749418849114904 0.4945521287414566 0.6209163008612737 1.0 0.9694760002142484 16 Q9UIQ6 1 +Ubiquitin like protein conjugating enzyme activity 0.428144706272807 0.4929554726530905 0.6220440499132474 1.0 0.9694760002142484 8 Q9NR09,Q9Y3C8,Q16763,P49427,P61086,P61088,Q9C0C9 7 +17 beta hydroxysteroid dehydrogenase nadpplus activity 0.6717456111295206 0.4837164553390046 0.6285871132813918 1.0 0.9719534694816192 2 Q8NBQ5 1 +P type calcium transporter activity 0.662925635020353 0.4700359755110855 0.6383293150551177 1.0 0.9728098452667692 3 P16615 1 +Carbohydrate kinase activity 0.4214973065223 0.4660315910272484 0.6411928881994879 1.0 0.9728098452667692 8 P17858,Q9Y223 2 +Potassium ion transmembrane transporter activity 0.6613651424784592 0.4656276813778316 0.6414820253746221 1.0 0.9728098452667692 3 P05026,P05023 2 +Cis trans isomerase activity 0.334978722337922 0.4575342499048936 0.647287090355567 1.0 0.974577761797303 27 Q9H2H8,Q96AY3,Q6UX04,Q13356,O00170,Q9Y680 6 +P type potassium transmembrane transporter activity 0.6628022524014654 0.4566880840456343 0.6478952568632499 1.0 0.974577761797303 2 P05026 1 +Collagen binding 0.4351169560366063 0.4544827785619948 0.6494813843218523 1.0 0.974577761797303 7 Q92791,O75718 2 +Cxcr chemokine receptor binding 0.6608148393507864 0.4507780311622947 0.6521495364050862 1.0 0.9775107930798338 2 Q96J02 1 +Profilin binding 0.4530580528387973 0.4487896487476036 0.6535834065962138 1.0 0.9785893628817628 5 P42858 1 +Hydrolase activity hydrolyzing n glycosyl compounds 0.4164571212107874 0.445911985909572 0.6556608239068273 1.0 0.9806280881575912 8 O43598,P29372 2 +Protein adp ribosylase activity 0.6477799867461974 0.4280100012275449 0.6686438389945053 1.0 0.9838833668887002 3 Q9UGN5,Q7Z2W4 2 +Microtubule minus end binding 0.4466877585929795 0.426717655803359 0.6695849891286509 1.0 0.9838833668887002 5 Q9H6D7,Q9BSJ2 2 +Nucleoside diphosphate kinase activity 0.4270663899877501 0.4243235110487482 0.671329895046979 1.0 0.9838833668887002 7 O75414 1 +Single stranded telomeric dna binding 0.4263258496658528 0.4215829049126636 0.6733294863192256 1.0 0.9838833668887002 7 P22626,Q15554 2 +Calcium ion binding 0.3034089313097575 0.4191160819776834 0.675131298006828 1.0 0.9838833668887002 71 Q9BPX6,Q66K14,Q96AY3,P04350,Q02818,P80303,Q9Y4G8,P60660,Q9Y680 9 +Chloride channel inhibitor activity 0.6430361390333144 0.4152067176993522 0.6779905815290301 1.0 0.9838833668887002 3 Q9Y3S1 1 +Chloride channel regulator activity 0.6430361390333144 0.4152067176993522 0.6779905815290301 1.0 0.9838833668887002 3 Q9Y3S1 1 +Misfolded protein binding 0.3659080993759542 0.4128919179854295 0.6796858026898773 1.0 0.9838833668887002 14 P46379,Q9BUN8,Q9GZP9,Q0VDF9,P48723 5 +Glycosphingolipid binding 0.6403840650136978 0.4081267330212791 0.6831806345334472 1.0 0.9838833668887002 3 P07602 1 +Glycosaminoglycan binding 0.3462932066099514 0.3952437719531168 0.6926629915666236 1.0 0.9838833668887002 19 O14737,Q13685,P10586,P05067,P43034,P15586 6 +Glucosyltransferase activity 0.3721727570044277 0.392418503924048 0.6947490161081666 1.0 0.9838833668887002 11 P04062 1 +Protein deacetylase activity 0.4902220749088409 0.3904693999954393 0.6961894783635056 1.0 0.9838833668887002 4 O94776,Q13547,Q8IXJ6 3 +Deacetylase activity 0.416583747927026 0.3831075531627795 0.7016400194943133 1.0 0.9838833668887002 6 Q92769,Q13547,Q8IXJ6,P10768,O94776 5 +Nitric oxide synthase regulator activity 0.6305500331345293 0.3823744435223571 0.702183643890768 1.0 0.9838833668887002 3 P07900,P23634 2 +Carbon nitrogen ligase activity with glutamine as amido n donor 0.3994223731214559 0.3799816111170465 0.7039590654098566 1.0 0.9838833668887002 8 P08243,O43716,O75879 3 +Acidic amino acid transmembrane transporter activity 0.4319489076796202 0.3772951584046203 0.7059542698186805 1.0 0.9838833668887002 5 Q9H936,Q9UPY5 2 +Dna n glycosylase activity 0.4292452124958031 0.3684936843684047 0.7125051535099942 1.0 0.9849317158220484 5 P12004,P29372 2 +Flavin adenine dinucleotide binding 0.3229374435056433 0.3674952058788225 0.7132496672188875 1.0 0.9849317158220484 29 Q14534,Q8NB78,P16435,P49748,Q15392 5 +Guanyl nucleotide binding 0.3468248411218486 0.3620697330160577 0.7172999209075535 1.0 0.987178049682977 121 Q9Y3Z3,Q9BVA1,P04350,Q9BUF5,P07437,Q9Y4G8,Q13509,P68371,Q13885 9 +Phosphatidylinositol 3 5 bisphosphate binding 0.4248385488335602 0.3543335096601753 0.723088957596904 1.0 0.9878108536251916 5 Q92538,Q9Y4P8 2 +Alpha glucosidase activity 0.6192582254329079 0.3538138361969993 0.72347840359576 1.0 0.9878108536251916 3 P10253 1 +Proton transporting atp synthase activity rotational mechanism 0.3591789510768028 0.3491213377549371 0.7269982180217665 1.0 0.9890477261085996 12 P00846 1 +Proton channel activity 0.3591789510768028 0.3491213377549371 0.7269982180217665 1.0 0.9890477261085996 12 P00846 1 +Chemokine receptor binding 0.4228047692184229 0.3478772244343234 0.7279323904922856 1.0 0.9890477261085996 5 Q96J02,P48681,O43776 3 +L amino acid transmembrane transporter activity 0.3748628109382815 0.3444243918495621 0.7305271477044255 1.0 0.9890477261085996 9 Q9Y619,Q9H936,Q9UPY5,O75746 4 +Solute cation antiporter activity 0.6136514247846215 0.3400490912798729 0.7338195588540974 1.0 0.9890477261085996 3 P51790,P08195 2 +Structural constituent of synapse 0.4033963861504053 0.3398006583389845 0.7340066521008604 1.0 0.9890477261085996 7 P56545,Q15334 2 +Intramolecular transferase activity phosphotransferases 0.4706662247265384 0.3337137643845325 0.738595561979597 1.0 0.9890477261085996 4 P18669,O95394,P36871 3 +Ubiquitin like protein conjugating enzyme binding 0.3580640190945185 0.3320770081705038 0.7398311107796602 1.0 0.9890477261085996 11 Q96GG9,Q9BTE7 2 +Translation elongation factor activity 0.3546194255243946 0.3293886293448817 0.7418619611872674 1.0 0.9890477261085996 12 P29692,Q05639 2 +Tbp class protein binding 0.3849263338022818 0.3266932271474835 0.7438999233800776 1.0 0.9890477261085996 8 Q14919 1 +Neutral amino acid transmembrane transporter activity 0.3990135193281234 0.3236012939821258 0.7462399081850659 1.0 0.9890477261085996 6 Q96NB2 1 +Cation cation antiporter activity 0.6134481616429381 0.3213451789502633 0.7479488225333439 1.0 0.9890477261085996 2 P08195 1 +Calcium cation antiporter activity 0.6134481616429381 0.3213451789502633 0.7479488225333439 1.0 0.9890477261085996 2 P08195 1 +Solute proton antiporter activity 0.6134481616429381 0.3213451789502633 0.7479488225333439 1.0 0.9890477261085996 2 P51790 1 +G protein beta subunit binding 0.6114607485922592 0.3164306408742351 0.7516756627974526 1.0 0.9890477261085996 2 P63218 1 +Hexosyltransferase activity 0.3176519878880157 0.3164071374175052 0.751693500167472 1.0 0.9890477261085996 38 Q13126,P37287,P35573,P04062,P46976,P15291,Q9BT22,Q6ZXV5,Q16880,Q16739,Q2TAA5 11 +Fructose 6 phosphate binding 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.9890477261085996 3 P17858 1 +Phosphofructokinase activity 0.6030626626051941 0.3148358791910216 0.7528862683422655 1.0 0.9890477261085996 3 P17858 1 +Gtpase activator activity 0.3142142934322615 0.3042835260311605 0.7609118948136093 1.0 0.9891378581612108 42 P63167,Q15436,O14786,Q9H6Z4,Q15042,Q9P2J5,Q01968,Q15334,Q68EM7,Q9Y4G8,Q66K14,Q9H8V3,P52565,Q96P47 14 +Single stranded dna helicase activity 0.3486509743490674 0.3040743200679324 0.7610712706993978 1.0 0.9891378581612108 12 Q14566 1 +Transferase activity transferring sulphur containing groups 0.3523132870876501 0.2991217128538195 0.7648471798351884 1.0 0.9898869226723608 10 Q8NCH0,Q7LGA3 2 +Disulfide oxidoreductase activity 0.3064367634988909 0.2971859684228962 0.7663245337912112 1.0 0.990194409864111 24 P00390,P78417,Q6DKJ4 3 +Nucleoside kinase activity 0.4563745282160524 0.2949172805283714 0.7680570708008878 1.0 0.990194409864111 4 P30085 1 +Plus end directed microtubule motor activity 0.389580792977687 0.2933275937550876 0.7692717640147664 1.0 0.990194409864111 6 P33176 1 +Molecular carrier activity 0.3068748142127542 0.2776172915145047 0.7813061570256672 1.0 0.9975658231565998 27 Q9P0I2,O75880,Q8N4V1,Q5J8M3,P55060,Q9UIA9,P62826,Q8TEX9 8 +Clathrin light chain binding 0.5945677376614877 0.2764725480563024 0.7821851417245047 1.0 0.9975658231565998 2 O00291 1 +Glucocorticoid receptor binding 0.5942365021530415 0.2757221214044049 0.7827615035717845 1.0 0.9975658231565998 2 Q04917 1 +Dna binding bending 0.3835169825193219 0.2745299482871562 0.7836773919457491 1.0 0.9978048577747922 6 P09429,P26583,Q12948 3 +Small ribosomal subunit rrna binding 0.3825553652825779 0.2715982963912711 0.785930909515228 1.0 0.9991539858975368 6 P82912,P23396 2 +Endoribonuclease activity 0.311267033297457 0.2698475286477048 0.7872775560902525 1.0 0.9991539858975368 22 Q9UPY3,Q9UQ84,Q9BRJ7,O95707,Q96F86 5 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.3054906444718218 0.2629667241648046 0.7925762269710601 1.0 0.9991539858975368 28 Q9H0D6,Q9UQ84,Q9HBH5,Q8IV08,P28340,Q9NQT4,Q15024,Q9NZN8,Q9NQT5 9 +Telomerase activity 0.5782188491461748 0.2598916765938345 0.7949473318454854 1.0 0.9991539858975368 3 Q15554 1 +Rna directed dna polymerase activity 0.5782188491461748 0.2598916765938345 0.7949473318454854 1.0 0.9991539858975368 3 Q15554 1 +Armadillo repeat domain binding 0.5826432593574142 0.2502772558574567 0.80237294406705 1.0 1.0 2 Q9HCK8 1 +Demethylase activity 0.3352212699720471 0.2494229144062066 0.8030336620033061 1.0 1.0 12 Q8NB78 1 +Oxidoreductase activity acting on the ch nh2 group of donors 0.5809870818151819 0.24677364745821 0.8050834061374466 1.0 1.0 2 P23378 1 +Leucine binding 0.5809870818151818 0.2467736474582097 0.8050834061374468 1.0 1.0 2 Q8IWV8 1 +Solute anion antiporter activity 0.3612812027443722 0.2462339423680176 0.8055011420466129 1.0 1.0 8 P04920,O43826,P12236 3 +Alpha actinin binding 0.5705765407554628 0.2442295473004172 0.8070530443780406 1.0 1.0 3 O00151,Q8WX93 2 +Muscle alpha actinin binding 0.5705765407554628 0.2442295473004172 0.8070530443780406 1.0 1.0 3 O00151,Q8WX93 2 +Transferase activity transferring nitrogenous groups 0.3457349678477635 0.2385473016151187 0.8114566326125052 1.0 1.0 9 Q6YP21,O15382,Q8TD30 3 +Electron transfer activity 0.2968847793918717 0.237370721143328 0.8123692018438382 1.0 1.0 50 P00390,Q9Y6M9,P14406,P03886,P00403,P16435,Q9UDW1 7 +Protein disulfide reductase nad p activity 0.3698479281842469 0.234173637464071 0.8148501803192854 1.0 1.0 6 Q6DKJ4 1 +Ribose phosphate diphosphokinase activity 0.573699900629359 0.2317526501890879 0.8167301354784426 1.0 1.0 2 O60256 1 +Diphosphotransferase activity 0.573699900629359 0.2317526501890879 0.8167301354784426 1.0 1.0 2 O60256 1 +Transferrin receptor binding 0.4281571295055153 0.2256445695641434 0.8214778731941568 1.0 1.0 4 O15111 1 +Phosphatidylinositol 3 4 5 trisphosphate binding 0.339656417883413 0.2182688002357442 0.8272196822074738 1.0 1.0 9 Q96AC1,Q9BWH2,Q92538 3 +Protein tyrosine phosphatase activity 0.3249452892485662 0.2180562972544938 0.8273852477616952 1.0 1.0 13 P10586,Q9Y217 2 +3 5 exodeoxyribonuclease activity 0.3754884741403727 0.2133478363145951 0.8310556643450293 1.0 1.0 5 P28340 1 +Mrna methyltransferase activity 0.3740205013565743 0.2096972808377987 0.8339039479300134 1.0 1.0 5 Q8N1G2,Q08J23 2 +Transketolase or transaldolase activity 0.5521198064993411 0.2089037126667812 0.8345234058180251 1.0 1.0 3 A1L0T0 1 +Nadplus binding 0.3598673300165762 0.2065654167344693 0.8363492711601173 1.0 1.0 6 Q8IXJ6,Q7Z2W4,Q16836,Q08426,P00367 5 +Ubiquitin protein transferase regulator activity 0.3251411491198807 0.1996385824264711 0.8417632507348993 1.0 1.0 10 Q9Y679,P61927,P68036,Q92990,P62841,P62913,P62081,P62829,P46777 9 +Peptide lysine n acetyltransferase activity 0.3221497674864627 0.1895665589406454 0.849648794096296 1.0 1.0 10 O14929 1 +Atpase binding 0.2900789644837079 0.1870798209227167 0.8515980494028725 1.0 1.0 26 Q9HCN8,Q93050,Q9BUN8,Q16740,Q9UII2,P35241,Q92542,Q9Y487 8 +Mannosyltransferase activity 0.3518722444996559 0.1856354439877778 0.8527306563648123 1.0 1.0 6 Q2TAA5,Q6ZXV5 2 +Histone kinase activity 0.3446048629985232 0.1634965001803116 0.8701275285276737 1.0 1.0 7 O14757,P54646 2 +Proteasome activating activity 0.3422885572139268 0.1619843362830769 0.8713181887979979 1.0 1.0 6 P62191,P35998,P17980,P43686,P62333 5 +Thiamine pyrophosphate binding 0.3532260379803269 0.1616715967576576 0.8715644727520282 1.0 1.0 5 A1L0T0 1 +Pre mrna intronic binding 0.3432958146380423 0.1602102922613853 0.8727154220683153 1.0 1.0 7 Q13148,P22626,Q09472 3 +Epidermal growth factor receptor binding 0.3410749834107454 0.1547044991090901 0.877054282924794 1.0 1.0 7 O60749,P18085,Q92600,Q99700,O00291,P62993 6 +Ribonuclease p activity 0.3907844464990075 0.1502230615962613 0.8805886318266378 1.0 1.0 4 O95707 1 +Ubiquitin like protein ligase binding 0.3013869823178526 0.1496302861830106 0.8810563122594326 1.0 1.0 97 Q96J02,P08183,Q9BUN8,Q9Y5X1,P07900,P61088,Q9HB71,Q93009,Q96HY6,Q96FW1,P07437,Q9NQC3,O94966,P29372,P15927,P46379,O75150,Q14527,Q9UQ80,Q8TCT9,P78371,P31689,Q13617,P25788,O94888 25 +Acetylgalactosaminyltransferase activity 0.5106030483764036 0.1426984325431272 0.8865283546985985 1.0 1.0 3 Q10471,Q86SF2 2 +Polypeptide n acetylgalactosaminyltransferase activity 0.5106030483764036 0.1426984325431272 0.8865283546985985 1.0 1.0 3 Q10471,Q86SF2 2 +K48 linked polyubiquitin modification dependent protein binding 0.3783543449579884 0.1294519086924772 0.897000075979232 1.0 1.0 4 Q92890 1 +Non membrane spanning protein tyrosine phosphatase activity 0.510102683007631 0.1283328351488731 0.8978855812442668 1.0 1.0 2 P24666 1 +Nad dependent protein deacetylase activity 0.4900596421471118 0.1167200687573719 0.9070818864097292 1.0 1.0 3 Q13547,Q8IXJ6 2 +Chaperone binding 0.2857459173469072 0.1123453532743819 0.9105495826809014 1.0 1.0 37 Q9HCN8,O95433,Q14108,Q15185,O15212,P31689 6 +Cysteine type peptidase activity 0.2846420443764594 0.1072317745453366 0.9146051083097428 1.0 1.0 43 O95630,Q96FW1,Q9HBH5,O00487,Q86UV5,Q96K76,Q92905,Q92890,Q9NUQ7,P51784,Q93009,O94966,Q9Y4E8,Q9BT78,P55210 15 +Histone deacetylase activity h3 k14 specific 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 1.0 2 Q13547 1 +Pyrimidine nucleotide binding 0.3232758620689656 0.1049916600695128 0.9163824264443424 1.0 1.0 5 P09884,Q9H773,P08238,Q16851 4 +Protein tyrosine serine threonine phosphatase activity 0.3157545605306737 0.1049856037435199 0.9163872321345964 1.0 1.0 6 Q99956,P51452,O75319,Q9UNI6,Q8WUK0 5 +Molybdopterin cofactor binding 0.486253726399485 0.1019668654044547 0.9187829755402912 1.0 1.0 2 Q5VT66 1 +Ligase activity forming phosphoric ester bonds 0.351546101813193 0.0919545398298099 0.9267341584577315 1.0 1.0 4 O00442 1 +Iron ion binding 0.2765170951455372 0.0844650991420927 0.9326866504997544 1.0 1.0 21 Q15800,Q16850,P22830 3 +Udp glucosyltransferase activity 0.3085168515013319 0.0842657964515832 0.9328451061283324 1.0 1.0 7 P46976,Q16739 2 +Antioxidant activity 0.2804859169897593 0.0831291863373764 0.9337488188158614 1.0 1.0 19 P78417,Q6DKJ4 2 +L aspartate transmembrane transporter activity 0.3410672853828211 0.0799232625964828 0.9362982881336704 1.0 1.0 4 Q9H936,Q9UJS0,O75746 3 +Sumo transferase activity 0.3404043752071541 0.0792098722292575 0.936865692363534 1.0 1.0 4 P14373,Q96MF7,P49792 3 +Dna polymerase binding 0.2887254989431868 0.0773733664917514 0.9383265277130152 1.0 1.0 9 P09429,P12004,Q15185 3 +Cargo adaptor activity 0.2947852833258689 0.0728170081608792 0.9419517363310465 1.0 1.0 8 Q9BXS5,Q96CW1 2 +Cardiolipin binding 0.4322623385226978 0.0634523084128621 0.949406335043044 1.0 1.0 2 O60313 1 +Phosphatidylglycerol binding 0.4322623385226978 0.0634523084128621 0.949406335043044 1.0 1.0 2 O60313 1 +G protein coupled receptor binding 0.2673067618441109 0.0631279472048575 0.9496646200251666 1.0 1.0 27 Q96J02,Q15334,Q9Y4G8,O00560,P31689 5 +Translation regulator activity 0.2720155905750915 0.0622264591765083 0.9503824919393128 1.0 1.0 78 P00374,P41214,Q06787,P49770,Q9NR50,P29692,P27635,P55010,P46199,Q13144,Q15056,O15372,P63241,Q9Y262,Q14232,O75821,Q92905,P35268,O00425,P46781,Q05639,Q9ULC4,Q14240,Q14197 24 +Peptidase activator activity involved in apoptotic process 0.4221338634857456 0.059844638343835 0.9522793730063036 1.0 1.0 3 P63244,Q9BXK5 2 +Sumo ligase activity 0.4229877442861953 0.0592800099990404 0.95272908282021 1.0 1.0 2 Q96MF7 1 +Spectrin binding 0.2878949036273285 0.0587783463628211 0.953128655734614 1.0 1.0 6 Q12955,P35611 2 +Phosphatidylinositol phosphate 4 phosphatase activity 0.4163630341172711 0.0566562430393552 0.9548190309882236 1.0 1.0 2 Q01968 1 +Atp dependent dna dna annealing activity 0.3158766987073205 0.0565972118634249 0.9548660555973928 1.0 1.0 4 P28370,P04637,P46063 3 +Dna dna annealing activity 0.3158766987073205 0.0565972118634249 0.9548660555973928 1.0 1.0 4 P28370,P04637,P46063 3 +Histone methyltransferase activity 0.270404804450516 0.0517770527761115 0.9587063402519672 1.0 1.0 20 Q86X55,Q9H7B4,Q99873 3 +Inositol phosphate phosphatase activity 0.4051438813361559 0.0515194117030864 0.958911634088362 1.0 1.0 3 Q01968 1 +Dynein complex binding 0.2887709479239606 0.0510521594944502 0.9592839574377804 1.0 1.0 7 P43034 1 +Phosphatidylinositol 3 phosphate binding 0.2822047279543224 0.0510241179242167 0.9593063022518598 1.0 1.0 6 Q9Y4P8 1 +Ligase activity forming carbon nitrogen bonds 0.2673544497812493 0.0478659525168022 0.961823074228561 1.0 1.0 21 Q9NRF8,O75879 2 +Amino acid cation symporter activity 0.3822457767472795 0.047066088357403 0.9624605549410838 1.0 1.0 2 Q9H936 1 +Inositol tetrakisphosphate phosphatase activity 0.3805895992050463 0.0467405479104696 0.9627200130857028 1.0 1.0 2 Q01968 1 +Supercoiled dna binding 0.2766117718328876 0.0456452796280292 0.9635929788368678 1.0 1.0 5 P09429,P26583 2 +R smad binding 0.3000977371661281 0.0456448970712539 0.963593283755202 1.0 1.0 4 Q9H6Z4,Q9UPN9 2 +Carbon nitrogen lyase activity 0.3777133723214822 0.0418462614384161 0.966621255994972 1.0 1.0 3 O75223 1 +Glucuronosyltransferase activity 0.3318979794634102 0.0409969068753616 0.9672983617466212 1.0 1.0 2 Q93063 1 +Class i dna apurinic or apyrimidinic site endonuclease activity 0.3206359721762283 0.0404025436644845 0.967772202355738 1.0 1.0 2 P23396 1 +Rna strand annealing activity 0.269733285678788 0.0396314140542871 0.9683869823121718 1.0 1.0 5 Q15056 1 +Histone acetyltransferase binding 0.2893602916804744 0.0396112728290891 0.9684030400756978 1.0 1.0 4 P12004,P04637,Q8IXJ6 3 +Ccr5 chemokine receptor binding 0.2891685988738116 0.0394933481715689 0.9684970567712816 1.0 1.0 2 P48681 1 +Single stranded dna 3 5 exodeoxyribonuclease activity 0.2775753560781843 0.0393347344753564 0.9686235139288436 1.0 1.0 2 Q07864 1 +Nucleotide diphosphatase activity 0.3658051689860783 0.0388454254294051 0.9690136278905256 1.0 1.0 3 P41250,Q9BY32 2 +Trna specific ribonuclease activity 0.2672413793103469 0.0376083636857941 0.969999939384077 1.0 1.0 5 P78346,Q99575,O15091,O95707 4 +Peptide n acetyltransferase activity 0.2685787386766409 0.0349690236048463 0.9721044413416496 1.0 1.0 13 O14929 1 +Dna apurinic or apyrimidinic site endonuclease activity 0.320742213386344 0.0321391535934676 0.974361079474291 1.0 1.0 3 P27695,P23396 2 +Histone threonine kinase activity 0.3101391650099351 0.0313219125449678 0.975012815296096 1.0 1.0 3 Q9Y4B6,O14757 2 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides 0.2652180284160644 0.0312503514654923 0.975069884839252 1.0 1.0 9 Q8IXJ6,O94776,Q13510,Q8IYS1 4 +Coreceptor activity 0.3081027957075593 0.0311882331136353 0.9751194239657386 1.0 1.0 3 O14786 1 +Ccr chemokine receptor binding 0.2892644135188806 0.0302406413973247 0.9758751361931476 1.0 1.0 3 O43776,P48681 2 +Fibroblast growth factor binding 0.2419622141199826 0.0237159018166211 0.9810792217579882 1.0 1.0 4 P39019,P15880,Q92896 3 +Growth factor binding 0.2609100656871468 0.023314322591308 0.9813995470437932 1.0 1.0 11 O00560,Q92896 2 +Nf kappab binding 0.2632373003574303 0.021935790223582 0.9824991751674336 1.0 1.0 13 P60900,Q09472 2 +Atp dependent chromatin remodeler activity 0.2197547232349979 0.0204825354392075 0.983658443855386 1.0 1.0 4 Q9H4L7,P28370,Q9HCK8 3 +Sequence specific single stranded dna binding 0.2574301882656191 0.0186302495986164 0.9851360713304204 1.0 1.0 9 P22626,Q15554 2 +Steroid dehydrogenase activity 0.2590201624758236 0.0140141260628904 0.988818711175368 1.0 1.0 7 Q3SXM5,Q9HBH5 2 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9cc90908cc2611021ff0090439c37dff05d01fc7 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Ap 2 adaptor complex binding", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Bmp receptor binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "Butyrate coa ligase activity", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide 1 phosphate binding", "Ceramide 1 phosphate transfer activity", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromatin insulator sequence binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co receptor binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase activity involved in apoptotic process", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H3 histone acetyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di methyl lysine 27 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor i binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n acetyltransferase activity acting on acetyl phosphate as donor", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular sequestering activity", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosamine synthase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter binding", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on metal ions", "Oxidoreductase activity acting on metal ions nad or nadp as acceptor", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphate ion transmembrane transporter activity", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol n acetylglucosaminyltransferase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphatidylserine flippase activity", "Phosphatidylserine floppase activity", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Platelet derived growth factor receptor binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein hormone receptor activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein sequestering activity", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor serine threonine kinase binding", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Stat family protein binding", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur amino acid transmembrane transporter activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo polymer binding", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific endopeptidase activity", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATRX", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPNT1", "BPTF", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT2", "CNOT9", "CNP", "COASY", "COIL", "COL4A3BP", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM129B", "FAM208A", "FAM213A", "FAM49B", "FAM50A", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FOXRED2", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GID8", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS4", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRIG2", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MORC2", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MVK", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NEO1", "NES", "NFS1", "NFU1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTKN", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAB1", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TFAM", "TFB1M", "TFCP2", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM192", "TMEM201", "TMEM30A", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPMT", "TPP1", "TPP2", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TST", "TTC1", "TTC26", "TTC4", "TTF2", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXN2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBLCP1", "UBP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VMP1", "VPS16", "VPS18", "VPS25", "VPS33B", "VPS35", "VPS36", "VPS37B", "VPS37C", "VPS4B", "VRK1", "VRK3", "VTA1", "VWA8", "WARS", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK2", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H13", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZFYVE26", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF148", "ZNF207", "ZNF281", "ZNF326", "ZNF512B", "ZNF598", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AASDHPPT", "ABCB1", "ABHD10", "ABHD12", "ABRAXAS2", "ACAD9", "ACADVL", "ACAT2", "ACOT7", "ACP1", "ACP6", "ADD1", "AGAP3", "AGL", "AHCYL1", "AHSA1", "AIMP1", "AIP", "ALDH6A1", "ALG1", "ALG11", "ANK3", "ANKLE2", "ANO6", "AP1M1", "AP2M1", "APEX1", "APP", "ARF4", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ASAH1", "ASNA1", "ASNS", "ATG9A", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B4", "ATP5L", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V1B2", "ATPIF1", "ATXN2", "AUP1", "B4GALT1", "BAG6", "BAIAP2", "BCAT2", "BCL2L13", "BIRC6", "BOD1L1", "CACYBP", "CADM1", "CAPN1", "CARM1", "CASP7", "CCNB1", "CCT2", "CDC34", "CDK4", "CDK6", "CERS2", "CHD8", "CHEK1", "CHKA", "CHST14", "CHUK", "CLASP1", "CLCN3", "CLN5", "CLPP", "CMPK1", "CMTR1", "CNDP2", "CNOT2", "CNOT9", "COL4A3BP", "COPS4", "COPS5", "COPS6", "COX2", "COX7A2", "COX7A2L", "CPT2", "CPVL", "CRTAP", "CSE1L", "CTBP1", "CTBP2", "CTCF", "CTH", "CTPS2", "CTSA", "CUL2", "CUTA", "CWC27", "CYB5B", "CYP51A1", "DCAF1", "DCTPP1", "DCUN1D1", "DCUN1D5", "DDRGK1", "DDT", "DERL1", "DERL2", "DHCR24", "DHFR", "DHPS", "DHRS4", "DHX36", "DICER1", "DIS3", "DNAJA1", "DNPH1", "DRAP1", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DYNC2H1", "DYNLL1", "ECE1", "ECT2", "EDC3", "EEF1A2", "EEF1D", "EHHADH", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2D", "EIF3G", "EIF3H", "EIF3L", "EIF4A2", "EIF4H", "EIF5", "EIF5A", "EMC3", "EMC4", "EP300", "EPHX1", "ERAP1", "ERCC3", "ERMP1", "ESD", "EXO1", "EXOSC3", "EXOSC5", "EXOSC7", "EXT2", "FADS2", "FAM98B", "FECH", "FERMT2", "FKBP10", "FKBP7", "FLII", "FMR1", "FOXC1", "FUCA1", "FUNDC2", "GAA", "GALNT2", "GALNT7", "GARS", "GATB", "GATC", "GBA", "GBF1", "GCLM", "GGCT", "GLB1", "GLDC", "GLG1", "GLMN", "GLUD1", "GNE", "GNG5", "GNS", "GPR107", "GPT2", "GRB2", "GSR", "GSTO1", "GUSB", "GYG1", "GYS1", "HADH", "HAGH", "HAT1", "HAUS4", "HCCS", "HDAC1", "HDAC2", "HIP1", "HLTF", "HM13", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HS2ST1", "HSD17B11", "HSDL1", "HSP90AA1", "HSP90AB1", "HSPA13", "HSPA14", "HTT", "ICMT", "IGF2BP3", "ILVBL", "IPO4", "IQGAP2", "ITCH", "ITPA", "KDELR1", "KDM1B", "KIAA0391", "KIF5B", "KYAT3", "LARS", "LBR", "LLGL1", "LMAN1", "LNPEP", "LTA4H", "M6PR", "MARC1", "MBOAT7", "MCM2", "MCM5", "MCM6", "MCTS1", "MED1", "MFSD10", "MFSD3", "MGEA5", "MICU1", "MIF", "MMGT1", "MPG", "MRPL58", "MRPS11", "MSH2", "MSH6", "MSMO1", "MTA2", "MTAP", "MTCH1", "MTIF2", "MTMR6", "MYL6", "NAGLU", "NAMPT", "NARS", "NCLN", "NCSTN", "ND1", "NDUFAF7", "NDUFB9", "NES", "NME6", "NOB1", "NPC1", "NPEPPS", "NRP1", "NSMCE2", "NSUN2", "NUCB1", "NUCB2", "NUDT16L1", "NXN", "OCRL", "OPA1", "OSBP", "OSBPL9", "OSGEP", "OTUB1", "P3H4", "PA2G4", "PAFAH1B1", "PAFAH1B3", "PALLD", "PARL", "PARP2", "PCNA", "PCYOX1", "PDCD5", "PDLIM1", "PEBP1", "PEX5", "PFDN6", "PFKL", "PFN1", "PFN2", "PGAM1", "PGM1", "PGM3", "PGRMC2", "PIGA", "PIK3C2A", "PITPNB", "PITRM1", "PLA2G15", "PLD3", "PM20D2", "PNKP", "POLA1", "POLD1", "POLE", "POLE3", "POM121C", "PON2", "POP1", "POP4", "POR", "PPIL2", "PPIL3", "PPP2R5C", "PPT1", "PRCP", "PRKAA2", "PRMT1", "PRMT3", "PRMT9", "PRPSAP2", "PSAP", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC6", "PSMD14", "PSMD7", "PTGES3", "PTPMT1", "PTPRF", "QTRT2", "RAB35", "RAB3GAP1", "RACK1", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RCC2", "RDH14", "RDX", "RECQL", "RIC8A", "RIDA", "RNF40", "RPA2", "RPL10", "RPL11", "RPL22", "RPL23", "RPL29", "RPL37", "RPL5", "RPP30", "RPS15", "RPS19", "RPS2", "RPS3", "RPS7", "RPS9", "RTCA", "RTN4", "SAE1", "SAMHD1", "SCARB1", "SCARB2", "SCO1", "SCPEP1", "SDCBP", "SDF2L1", "SEC11A", "SEC23A", "SFXN2", "SIGMAR1", "SIRT2", "SLC16A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A6", "SLC29A1", "SLC35B2", "SLC35F2", "SLC37A4", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SMARCA1", "SMARCAD1", "SMYD3", "SNX2", "SNX3", "SNX6", "SNX9", "SPR", "SQLE", "SRP9", "STAMBP", "SUN1", "SUZ12", "TARDBP", "TBC1D9B", "TECR", "TERF2", "TFRC", "THOP1", "TIMM17A", "TIMM17B", "TIMM23", "TMEM201", "TMTC3", "TOMM22", "TP53", "TPP1", "TRAM1", "TRIM27", "TRIM33", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TWF2", "TWNK", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBR2", "UBXN7", "UFC1", "UFD1", "UFSP2", "UGCG", "UGP2", "UGT8", "UNC119B", "UQCR10", "USP11", "USP15", "USP19", "USP47", "USP48", "USP7", "VDAC1", "VDAC2", "VMP1", "WDR41", "WIPI2", "WNK2", "XPO7", "XRN2", "YWHAH", "ZC3HAV1", "ZMPSTE24", 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5.200191597215617 8.266631122869512 0.6892344730359738 0.3168120798934317 0.2123860213374901 0.0708539020687588 0.013686897100908 0.0014288116845806 0.0219683780231214 +Urinary glycosaminoglycan excretion 6 7 2.455596661314264 0.0140650921026679 2.9490291262135924 6.563106796116505 0.4749855796693131 0.2196485727407601 1.2846457065606351 0.9261036754709504 1.6390629541794843 0.2603486997442626 0.0614672516091427 0.0683810764565047 0.1349531130589082 8.117802851328154e-07 2.9060507565671657e-06 +Mental deterioration 23 93 2.442627209566248 0.0145807899600922 26.16990291262136 97.51699029126212 1.0638646072845834 0.3178098854339388 8.217921866043707 8.355116022963852 1.9487627742005753 0.3762024781602087 0.0854582473733829 0.0009951056419742 0.0096006639063748 0.0001091258199221 0.0004332577919003 +Elevated pulmonary artery pressure 7 24 2.4363574343608265 0.0148360163980167 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.3146140007552462 0.0656244339904668 0.0540767090111314 0.0014145919227058 0.0292985138163441 +Airway obstruction 4 16 2.4247620285036144 0.0153184243301924 4.116504854368932 15.12378640776699 0.9459797966632624 0.3434111484412289 1.9597947726604712 2.1010208413382245 1.0021021721123982 0.3085532788047633 0.2179309117901036 0.2400196775334175 0.107004894081217 0.0131393408571549 0.1522313234140426 +Progressive gait ataxia 5 11 2.416668352029024 0.0156632811271613 3.3810679611650487 11.0873786407767 0.9190295749650902 0.2658532875386696 1.7592835107251577 1.880439920211323 1.2434873962438642 0.2734996669217905 1.0 0.1029565435856987 0.1993869387044997 0.0021013452038761 0.0006524167345181 +Respiratory arrest 2 6 2.401436788295425 0.0163308302987617 2.0558252427184467 7.070388349514563 1.3186130117670736 0.2232983865916446 1.389730031946098 1.4320861436977392 0.8270726521635177 0.2287950263954721 1.0 1.0 0.0126574737404708 0.0088528623379573 0.0547354250806853 +Abnormality of the phalanges of the toes 6 14 2.394472652788534 0.0166442846014496 4.310679611650485 16.216019417475728 0.657145942013654 0.4547589157091309 2.217665729026992 3.9902107980926513 0.8561226490575587 0.3038881989407645 1.0 1.0 0.5782406044087871 0.0211615022147258 0.1438679293538954 +Abnormality of pulmonary circulation 8 29 2.389903521366672 0.016852799238064 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 3.349932259027002 4.295622811850572 1.233599840087162 0.3264185554851845 0.3652866553541316 0.0901677189318956 0.0195066935662917 0.0011619065980142 0.0151785585759159 +Progressive visual loss 4 19 2.388331338836468 0.0169250749518929 5.325242718446602 22.429611650485437 0.7316954387450431 0.34231947196034 2.467466703195611 2.985791083259841 1.255625436621734 0.3056268024259221 1.0 0.0473022522201117 0.034172513126223 0.0338869207736729 0.1522594518276387 +Neuronal loss in central nervous system 7 13 2.3870887414110107 0.0169823914494453 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 1.0 0.1321770275159086 0.2518545844225215 0.0007082692598358 0.0004849181964336 +Ventricular preexcitation 3 7 2.377914294158998 0.0174108721650114 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 1.0 0.0035263772514821 0.014058804472369 0.0009927961558234 0.012134686324044 +Increased cerebral lipofuscin 4 5 2.374817991503758 0.0175576054378423 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 1.0 1.0 0.0921025797166938 1.8654270901726772e-06 5.5966724052351854e-05 +Infantile muscular hypotonia 15 67 2.3741318513830287 0.0175902678527795 13.900485436893204 66.00242718446601 0.112520259201691 0.5910142955974006 6.420333276084778 7.344999879849499 0.9387709887425064 0.3382916955300774 0.1358287106166098 0.0056824209140955 0.0035055337280592 0.0012595539305311 0.0012697921886603 +Abnormal speech prosody 2 8 2.370917879085238 0.0177439730476247 1.7184466019417477 7.531553398058253 0.8238611105871386 0.3292070194756458 1.3593793253030109 1.1305443806694235 1.0768574157850217 0.2870822069632543 1.0 0.0028214739728005 0.0113213926532688 0.0075105395483816 0.0472723399635447 +Abnormal csf protein level 7 13 2.3571124092134563 0.0184176707147003 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 1.0 0.1683799151698467 0.0538434207197609 0.0003242449817876 0.0004925844777632 +Joint contracture of the hand 13 51 2.3461519950251284 0.018968370422852 9.33495145631068 47.52427184466019 0.6899528308551226 0.5319748768374064 4.138903957392258 6.987637711020041 0.8046601985034184 0.3400891059680895 1.0 1.0 0.241997479766437 0.0039579958356395 0.0128608007627308 +Abnormal retinal artery morphology 5 23 2.338992337786029 0.0193358300454242 6.985436893203883 21.733009708737864 0.6882820766413594 0.2247118762866906 2.318097134221824 2.0518941450352677 1.8438290687413053 0.2835525492265039 0.0187248462664909 8.49425410120894e-05 0.0013172485850202 0.0012637063207462 0.0102581006485124 +Fluctuations in consciousness 2 7 2.335430677039483 0.0195209334120936 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 1.0 0.0858288536093336 0.1677870330809631 0.0103266247469619 0.0627230635966129 +Abnormality of corneal stroma 6 12 2.326281301282763 0.0200035488880312 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 0.0255379046939669 0.0313211948286675 0.1100932826860655 0.0549638769430376 0.0241125551203947 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11.28883495145631 53.067961165048544 0.3684545773204664 0.5543810617665341 5.43153070755638 4.378371679243168 0.93176226686647 0.3550469042424617 0.4296406588124546 0.0240209396081081 0.0381680758380543 0.0048737267586504 0.1963230713102622 +Amyotrophic lateral sclerosis 1 16 2.2592791657317464 0.02386602505413 4.453883495145631 16.203883495145632 1.0855969203541704 0.3037117925086244 2.3812188822255287 1.5445439412417563 1.0118111691913367 0.2917679915833991 0.0128371627497515 0.0158345246348345 0.0588586045542952 0.2631788935246822 0.3239485660907243 +Muscle spasm 9 57 2.2583474282657803 0.0239240075474991 12.46116504854369 57.41990291262136 0.5782385518256496 0.5270109112328661 4.685854213547734 5.0957713280196595 0.8793305042203639 0.3427211662973412 0.4047025240866349 0.1123544518992548 0.0011140245722043 0.0097493412203365 0.0064995796940839 +Weak voice 0 5 2.2544808715189752 0.0241659327138923 1.550970873786408 5.737864077669903 0.4344739918343515 0.5015398770888346 1.4038172747545303 1.1779624093475138 0.8128091354527174 0.2801301484192541 1.0 1.0 1.0 0.373917962138579 0.6141484764039431 +Increased circulating antibody level 3 14 2.2412866266061493 0.0250075146628634 3.2402912621359223 15.145631067961164 0.5908116743587006 0.4340890712285613 1.9578142936372311 2.533878285328643 0.9673694377645128 0.2975830104493745 0.2045238727654858 0.225458320485449 0.4072036678679048 0.0418926794657358 0.2698738667135572 +Central scotoma 2 8 2.2372547596348307 0.0252696942100956 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 1.0 0.0070670490819082 0.0021303683071518 0.0270423729706739 0.1429195355686209 +Insidious onset 1 6 2.236017769390353 0.0253506072097098 1.5606796116504855 4.798543689320389 1.010752209781939 0.2963577845750634 1.0233713199598442 0.8899098980975658 0.9610714276026808 0.2642783107441792 1.0 1.0 0.1265462710440741 0.0442367692127036 0.1472320281277068 +Abnormality of head blood vessel 5 25 2.2332651736349987 0.0255314626991571 7.512135922330097 24.881067961165048 0.5951213621611695 0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 0.0263487782631664 0.0001737607377435 0.0025924072114898 0.0032541277976547 0.0023517659127708 +Broad phalanx of the toes 3 6 2.2202527137316226 0.0264016178320329 1.5604938271604938 5.439506172839506 0.5670705717196924 0.4763752885673162 1.212861020438932 1.4330903336087657 0.8595553173769842 0.3029593861447532 1.0 1.0 1.0 0.0080316637526189 0.0752360475117867 +Nephropathy 4 21 2.2147495191892923 0.0267772618815742 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.2408640795463657 0.037406554204333 0.1290920553826253 0.0732204111174843 0.2106641019319211 +Polyneuropathy 6 15 2.211998792299051 0.0269667483811049 5.689320388349515 18.633495145631063 1.1475655107151586 0.297256939859202 2.871111980426299 2.8359934163787166 1.1251440285742276 0.3008764483611514 1.0 0.0247821522094747 0.0890100643743446 0.0372180748890915 0.0126413335687205 +Glomerular sclerosis 6 31 2.209447388698812 0.0271435379817306 7.25 32.54611650485437 0.2790083976902152 0.6006479285561297 3.704251689953623 2.775641177744643 0.8096022885008873 0.3229927827056285 0.2536724424322742 0.0416950911647941 0.1421535555390922 0.0013823477663658 0.0505496054928521 +Hand muscle weakness 3 11 2.202047822619657 0.0276619305739527 2.8058252427184467 10.820388349514564 0.4952781372617184 0.5553355274479741 1.7253577224537426 1.6697688476326478 0.7717943987196815 0.3071851204356355 1.0 1.0 0.2147385524083838 0.0220300654060922 0.0314674363117242 +Abnormal circulating citrulline concentration 1 5 2.200023703009867 0.0278052133615958 1.519417475728155 4.283980582524272 0.9322911204120568 0.2795135602214257 1.0297099461920487 1.0355035731992424 1.235992875942202 0.2843671782204088 1.0 0.0013899505248691 0.0056684159955205 0.0331187861076589 0.1137231346556503 +Avascular necrosis 6 21 2.184256999541145 0.0289433686051772 5.070388349514563 21.203883495145632 0.6420454351604097 0.3947374085674277 2.2614105153836106 2.2592172512550373 1.1319127818663337 0.3183649666305153 0.2145999915509279 0.236404668572991 0.0173242512102645 0.0122427571760862 0.0202989209094577 +Hemiparesis 3 13 2.182636601571829 0.0290625821229368 4.492718446601942 16.453883495145632 0.5632847994166561 0.5250125610456521 2.3039529956499933 2.7457486053720115 0.80325121159606 0.3108877318797908 0.224551409798482 0.0323055044295255 0.0198486300115185 0.0578139139832752 0.1681830958171223 +Deep plantar creases 4 6 2.17996022626464 0.0292604099405662 1.8349514563106797 5.186893203883495 0.878985239421048 0.4043272377350911 1.2929764516183682 0.5365505235508999 0.7767472061372565 0.306948917766608 1.0 1.0 1.0 0.3258327648280404 0.0007595134217252 +Hypothermia 3 10 2.1761237155325386 0.0295460110453902 2.4174757281553396 9.49271844660194 1.0856169578047503 0.2588610618328691 1.611694349619475 1.8201795996814751 1.0634596616937388 0.2538467530049644 1.0 0.0051552423978184 0.0013262573806951 0.0021013452038761 0.0237749620613201 +Retinopathy 3 26 2.167263328746042 0.0302147809919992 7.716019417475728 27.516990291262136 0.7648928031827923 0.4912060355555205 3.3040774573673595 3.4588008851352714 0.8590527654816497 0.3424638793573584 1.0 0.3186897272236745 0.0428883183388871 0.1345125661941877 0.3622849467145124 +Abnormality of the septum pellucidum 15 39 2.162294919125045 0.0305954511157771 8.526699029126213 40.89563106796116 0.3444144169479532 0.6578867555611217 3.7722499501114135 4.8372824292966765 0.6626144836676359 0.3030567488250643 0.0782702131702164 0.0944907526770622 0.2854925496837373 0.0515614325360149 0.0072905074637843 +Diffuse white matter abnormalities 2 9 2.150651377256744 0.0315037268524707 2.9514563106796117 8.87135922330097 0.5952845668725205 0.3852144131329246 1.9847899342355348 1.8774220853320651 1.0510828155917642 0.2960660984241839 0.1041819332558558 0.1155957163384056 0.2223047329091382 0.1309570889500886 0.1315350963393062 +Gait ataxia 12 67 2.1491372916460234 0.0316235184022497 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.1532553720666863 0.0010195063934252 0.0010303514905405 0.0023026273958636 0.0149809111286618 +Abnormality of the basal ganglia 15 85 2.1401546454418763 0.032342271124091 17.890776699029125 83.85679611650485 0.1271244269035971 0.6626134068300666 8.310141913351396 8.194029168057385 0.7918134436835141 0.3209573863398475 0.0083283297967227 0.0002547827943066 8.805242251503307e-05 1.6356620689207375e-05 0.0024988104825475 +Clumsiness 8 19 2.1378614478275417 0.032527990012847 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 1.0 1.0 0.3777229935777695 0.0011347755104788 0.0001036773032702 +Phenotypic variability 19 100 2.1360865108223392 0.032672363042338 22.339805825242717 99.4368932038835 0.8464119152872666 0.5170730885331468 8.500203764614474 8.607030207254683 1.0360918895927824 0.3938137781932724 0.0283612865760146 0.001759344940526 0.0003080857787314 0.0030455587856786 0.0085998968292223 +Spinal muscular atrophy 3 11 2.1294089623631227 0.0332204396040718 2.371359223300971 11.631067961165048 0.4389210807063967 0.4570833112576819 1.7859905459385614 1.5453675923162358 0.9261268630430692 0.2826715354193165 0.0811240843842033 0.0901405579438761 0.1758008751515455 0.0840389641709933 0.0145952588649919 +Ventricular arrhythmia 8 36 2.128530596345175 0.0332931159512948 10.0 36.96601941747573 1.0415384316890377 0.3677574027458479 3.8522468541414527 4.8022861343455805 1.0152201826292362 0.3231502492090489 1.0 0.0817104171385654 0.0161157889533151 0.0007675886272756 0.0254058481796187 +Abnormal caudate nucleus morphology 2 10 2.116834142276011 0.0342739265923084 2.8519417475728157 10.133495145631068 0.4630014218675518 0.4635627378613905 1.7037711217888412 1.7774598482419672 0.9891574305728495 0.3131768373752813 0.0850069130381694 0.0043047615253927 0.0170518298819148 0.0136772183990335 0.0801939864225387 +Blurred vision 1 5 2.116654759371493 0.0342891590384826 1.4684466019417477 4.449029126213592 0.7772225957067546 0.3401357669580369 0.986055451759567 0.9450042528934012 1.0938682095756602 0.2939628040587096 1.0 0.0035263772514821 0.014058804472369 0.0768284795296569 0.2369865842622187 +Mucosal telangiectasiae 7 10 2.106814711890548 0.0351336437416209 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 0.1117415456151005 0.1239247827595126 0.2372212797486779 0.4986229205358068 0.0454470617698533 +Scotoma 2 11 2.099334900873983 0.0357873889013697 4.189320388349515 12.196601941747574 1.1271039056750725 0.2779036999445621 2.1128553643245884 2.0698220238662226 1.1901076059375446 0.2884356618441315 1.0 0.0151070197534971 0.0065760397653667 0.072741111398958 0.3103681353614002 +Postural instability 3 18 2.094568946854636 0.0362093280841604 3.533980582524272 17.79126213592233 0.4509430795614677 0.5268149729159746 2.1579185133601717 2.125919871541916 0.8315457301240203 0.299833681390129 1.0 1.0 0.4297892617739207 0.0521920382248859 0.3142493251196416 +Focal onset seizure 19 76 2.090333631880458 0.0365878401504393 16.099514563106798 82.12135922330097 -0.0223024178503984 0.7594854007669113 6.769957892146626 9.355691383286867 0.5659964350561253 0.2717716693943773 0.249875634735089 0.0917552048379735 0.176363523212896 0.0004485503426622 0.0007610973914441 +Abnormal temper tantrums 2 10 2.0820298525630423 0.0373397430381663 2.1480582524271843 8.533980582524272 0.0979227555463343 0.5941445565574304 1.916945668409979 0.9908859817098914 0.7730430886339895 0.273442894817072 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.0026581093268102 0.0183139901045195 +Slow decrease in visual acuity 1 7 2.0657282157550307 0.0388541495082939 2.313106796116505 7.985436893203883 0.7332483742783148 0.3617245659278226 1.567733834853386 1.5547551717475598 1.083959755774155 0.2999488674407273 1.0 0.0060764540616979 0.0237627189197599 0.1227655047468798 0.3470060894740981 +Corneal opacity 21 48 2.0610132891004285 0.0393017722901221 15.480582524271844 53.95631067961165 0.9517965339960472 0.3644495779961974 5.277458167452316 6.791845051563607 1.5225460520633525 0.3686110256368129 0.1892892539796192 0.2232696206807863 0.2730889833135627 0.3121640427125081 0.0110421424891882 +Abnormal renal tubule morphology 4 24 2.054956132170936 0.0398832419959565 5.12378640776699 23.57281553398058 0.5344796879802587 0.5091115156098857 3.0444469953961124 3.073064760825049 0.9046179239778558 0.3270470399524735 1.0 0.0427950226871739 0.029653655190088 0.0275014842073337 0.2561486974132024 +Myoglobinuria 1 9 2.046752853703141 0.0406823568858505 3.2184466019417477 10.385922330097088 0.0146173364855394 0.5490799263020073 2.1679146426079794 0.949755141559572 0.8532528520059285 0.2727996645960018 1.0 1.0 0.0170518298819148 0.0914454637274335 0.2738488340493723 +Retinal telangiectasia 1 5 2.04293633796944 0.0410587405631175 1.3106796116504855 5.007281553398058 0.8088648966265131 0.3483026313211161 1.0430456357811864 1.087191709833904 1.1553193033520868 0.3106693264231038 1.0 0.0035263772514821 0.014058804472369 0.0768284795296569 0.2369865842622187 +Abnormal corpus striatum morphology 3 16 2.0377847168745693 0.0415714674524665 3.783980582524272 16.274271844660195 0.5436026262586074 0.5269340846045785 2.1360147265981855 1.9458739529228473 0.8481478897769046 0.3232524565257521 0.1303690115854634 0.0104419310742173 0.0398064357050217 0.0080316637526189 0.0208457080812305 +Nasogastric tube feeding 6 24 2.032603199152335 0.0420926280421267 6.274271844660194 24.924757281553397 -0.2017983562148376 0.6842396558909075 3.2193315056974496 3.227110386389366 0.6504518910971607 0.2711215318475037 0.224551409798482 0.2471994937249445 0.4407605172427877 0.0578139139832752 0.026192552528094 +Splenomegaly 18 85 2.031933582998449 0.0421603801751306 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 0.2545884415897312 0.0945328632021978 0.1820864285977347 4.750539567487738e-05 0.0020695022526182 +Peripheral demyelination 5 18 2.0295515057247666 0.0424021485006993 4.524271844660194 16.973300970873787 0.9472740181618832 0.3208012027704231 2.3341893675900383 2.269845761985369 1.1784704386991718 0.3026863353342601 1.0 0.0136970422924113 0.005693097574516 0.0021298798430701 0.0095994200986085 +Pericardial effusion 3 5 2.026106793316992 0.0427538421053168 1.9466019417475728 5.980582524271845 0.6333430474464145 0.2773316461993735 1.2136213588737947 1.4646685732948297 1.3006352977804805 0.2635985168358294 0.0888737142889677 0.0987043131013681 0.018640880521655 0.0155574138143109 0.0204068190514482 +Hemianopia 3 6 2.0255220373530074 0.0428137879324643 2.0776699029126213 7.611650485436893 0.5790308557992101 0.4109966183023263 1.4034584217287485 1.4877037085527185 1.0055409588864108 0.2887898466516661 0.1229642662659278 0.0092510900433489 0.0354914601129098 0.0387286577629364 0.0623633603808868 +Hypoketotic hypoglycemia 2 7 2.02430061080291 0.0429392308309477 2.3470873786407767 7.560679611650485 1.365087782487965 0.212332843161917 1.4324316558480732 0.6923349575659244 0.8002406012991511 0.2265642620801705 1.0 1.0 0.0047533286028597 0.0020298329670106 0.0142438301551866 +Motor neuron atrophy 1 21 2.017126019642885 0.043682363930692 5.410194174757281 22.424757281553397 0.8356342611289532 0.3959768073616548 2.754377444710008 1.6813276911909307 0.954775311801755 0.3176984078794489 0.0187248462664909 0.0230307909848423 0.0832345551471358 0.344328227558065 0.0956411875170437 +Positive romberg sign 3 9 2.0073430437091755 0.0447131489087124 2.466019417475728 8.308252427184467 1.0733671875840938 0.3096488241780741 1.4485716699970723 1.6764009803624336 0.8283755892460324 0.2651507773538893 1.0 1.0 0.0088504827764808 0.050241067872642 0.004988841333209 +Hemiplegia hemiparesis 6 30 2.0014528739895434 0.045343607521874 8.230582524271844 37.351941747572816 0.1327462641813027 0.7047343581472495 3.968044277578164 5.718299794545226 0.6778790946379935 0.2933913145415446 0.4441106107995538 0.1373975853712186 0.1471505445955429 0.1201076315232539 0.2325836362790589 +Abnormal pericardium morphology 4 9 1.9974978245176325 0.0457711305500374 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 0.1340484499873519 0.1484538203623246 0.0041517217414646 0.0089321887950908 0.0234894970885714 +Toe walking 5 23 1.9964780289716653 0.0458819149342981 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 0.1943215284903705 0.2143583684675494 0.3896854720293997 0.007721883439699 0.0369035419304253 +Rhabdomyolysis 2 12 1.996163156046415 0.0459161664168918 3.0242718446601944 13.451456310679612 0.3809613122276756 0.4596197923813932 2.630920176410559 1.2027770518432574 0.9520162845961792 0.2764012957742299 1.0 1.0 0.0334071197556988 0.0356014336373073 0.1788436773996531 +Supranuclear gaze palsy 4 17 1.9882014149447096 0.046789418566687 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 2.2612229396433574 2.139608194404574 1.2188387108542005 0.2935859783151378 0.1522187563784268 0.0143944751365022 0.0538434207197609 0.0023954143814766 0.0025045817361718 +Capillary hemangioma 6 7 1.9861345720016483 0.0470183834007786 2.533980582524272 7.133495145631068 1.1471796350867234 0.2683759543048971 1.4112277515033682 1.3471092449900268 0.9767941621718578 0.2786452679412407 1.0 1.0 1.0 0.0453869127531283 0.0208457080812305 +Psychotic mentation 2 6 1.978696995777531 0.0478501314162476 1.3810679611650485 5.213592233009709 0.5390214400079423 0.4488271579257555 1.1095047549274055 1.177462183235361 0.9736664818107128 0.3100249330671143 1.0 0.0683810764565047 0.1349531130589082 0.050241067872642 0.0339846578092061 +Eyelid myoclonus 2 8 1.978376648487028 0.0478862320482318 2.004854368932039 9.531553398058252 0.5187806868364082 0.4301345640798078 1.347408778242444 0.9835908626114443 0.9516679014482394 0.2768543779231988 0.1229642662659278 0.1362745587685063 0.2590666885683055 0.534424974066877 0.1913237113672655 +Limited wrist movement 2 5 1.9735942617805973 0.0484278967440783 1.3519417475728157 5.033980582524272 0.5996596677114278 0.4085363950174713 1.0882965742387771 1.0765869657248284 0.9224773457089386 0.2739378776344282 1.0 1.0 0.0039135152062846 0.0015031185668187 0.0107435842434709 +Cerebral inclusion bodies 2 14 1.971350702243028 0.0486837756657401 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 1.0 0.1444128696349771 0.2732850813359189 0.0453869127531283 0.2168926648719501 +Visual loss 11 45 1.9685926465693595 0.0489998876735395 12.189320388349516 49.779126213592235 0.7709512625515322 0.4025114627500821 4.5744204921606055 5.175300864908489 1.242827263568942 0.3662286004483653 1.0 0.1668791053456315 0.0632048376565007 0.0139049729795663 0.0796125915144056 +Neck muscle weakness 4 14 1.9656827821133305 0.0493352649332476 4.206310679611651 15.46359223300971 0.939049769317174 0.3360301393876674 2.1919222801274123 2.3742417714011115 0.9901989764800458 0.2887083620559018 0.1943215284903705 0.2143583684675494 0.3896854720293997 0.034999603504981 0.1020257142116422 +Abnormal urine protein level 8 54 1.9604265365533136 0.0499459567336373 12.186893203883496 57.883495145631066 0.3263829049450854 0.5953561251667359 5.528524712203877 5.170023700672021 0.8651184877190968 0.3416430341577767 0.1532553720666863 0.0423539313401504 0.2115863552914892 0.0193741918373492 0.2866851003569236 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1498f88caac5addc199a1dab40fbcf1646d20bf2 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 4561, + "title": "Average number of proteins per term", + "value": 22.572462179346633 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6bea2204f8a0e17f80e760429b58fcbbd95eaa64 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cc55e96a66640d034defd33bd13e03fc2a06f2ac --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1599 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Postural tremor 0.8204889521154917 3.1543911983355053 0.0016083333620395 0.9993519313001268 0.5734301342763595 19 P04350,P03886,Q14108,Q9NR77,Q9H6K4,P00846 6 +Action tremor 0.6090524377826215 3.0478145082805144 0.0023051216796723 0.9999731648045176 0.5734301342763595 52 P07602,P04350,O14773,P03886,Q14108,Q9NR77,Q5JRX3,Q9H6K4,P00846,Q99720 10 +Dementia 0.584359934718295 2.99963081807684 0.0027030701926149 0.9999956502662056 0.5734301342763595 55 P07602,P04062,O43681,P04350,Q9NZJ7,O15118,P03886,Q14108,P00403,P05067,Q9Y487,P00846,P42858,Q13510 14 +Cortical dysplasia 0.6947478599284106 2.972813984432927 0.0029508322514362 0.99999859944546 0.5734301342763595 29 Q9BVA1,Q2M389,Q08J23,Q96N66,Q9NZ01,P07437,Q9NUQ7,Q13509,Q13885 9 +Dyskinesia 0.5403878361353543 2.8464709598143476 0.0044206761116893 0.9999999983249148 0.5734301342763595 59 Q8NC96,Q96T60,Q9BPX6,P04062,Q9UBX3,Q2M389,Q08J23,Q96N66,Q9NZ01,P03886,Q96F86,Q9NUQ7,P00846 13 +Limb ataxia 0.6826597909514784 2.843103622646325 0.0044676542422112 0.9999999986492768 0.5734301342763595 24 Q14108,Q9NR77,Q8IV08,P04062 4 +Rigidity 0.5711773634589288 2.834352390192562 0.0045918665976256 0.999999999235452 0.5734301342763595 54 Q8NC96,Q9BPX6,Q9Y3Z3,P07602,Q05639,P04062,O43681,P04350,P16278,P35270,Q9NZJ7,Q9H6K4,Q15392,P00846,P42858,Q96CU9 16 +Variable expressivity 0.5402504529613288 2.796683157583091 0.005163013759506 0.9999999999442144 0.5734301342763595 77 P00374,Q9Y3Z3,P07602,Q09472,Q9BVA1,P04350,Q9NZJ7,Q9Y5P6,P35270,P03886,Q9NR77,Q9BUF5,P00403,O95470,P43034,Q70HW3,Q13509,Q13885 18 +Chorea 0.5377979287903473 2.719055521968563 0.0065468617761648 0.9999999999999024 0.5734301342763595 82 Q9BWD1,Q9NZ01,P00846,Q99720,P42858,Q2M389,P04350,P03886,O43681,Q08J23,P35270,Q96IX5,Q96F86,Q9NUQ7,Q9H6K4,Q9BPX6,Q96T60,P07602,Q96N66,Q9NZJ7 20 +Bulbar signs 0.8353869285158464 2.6787790378567604 0.0073891136812827 0.999999999999998 0.5734301342763595 11 P07602,P04062,Q9NZJ7,P03886,P00846,Q99720 6 +Contractures of the joints of the upper limbs 0.5213573321152388 2.6599895690724624 0.0078143071534004 0.9999999999999996 0.5734301342763595 73 O00443,Q96AY3,P42892,Q15042,Q9NPF4,P49711,P16435,Q9NR77,P23786,P50542,Q15392,Q9Y6X9,Q6DKJ4,Q13509,Q99720,Q8IZA0,O75844,Q7LGA3 18 +Myoclonus 0.5344428780555244 2.6441137843959734 0.00819051177784 1.0 0.5734301342763595 86 P00374,P37287,Q9UBX3,Q14108,O75503,Q13315,Q9Y4G8,P00846,P42858,Q96CU9,Q8NC96,O95630,P03886,P00403,P05067,P50897,Q13510,Q96T60,P07602,Q05639,P04062,Q9NZJ7,O14773,Q9NPL8,P21281,Q96RR1 26 +Biliary tract abnormality 0.6488356594543601 2.6392255901297377 0.0083095665282433 1.0 0.5734301342763595 25 P07602,P04062,O43681,Q9NZJ7,P09601,Q14108,P50542,Q14739 8 +Abnormal biliary tract morphology 0.67748957454806 2.6189105712694767 0.0088211069228418 1.0 0.5734301342763595 22 P07602,P04062,O43681,Q9NZJ7,P09601,Q14108,P50542,Q14739 8 +Dysostosis multiplex 0.8677219413489954 2.6150245535816197 0.0089221041333309 1.0 0.5734301342763595 9 P16278,P54802,P10619,P08236,Q96AX1,P15586,Q9Y223 7 +Polymicrogyria 0.5089001036197486 2.5617819684097793 0.0104136670687824 1.0 0.5734301342763595 71 Q9BVA1,Q2M389,Q9Y5P6,Q08J23,Q96N66,Q15042,Q9NZ01,P21281,P07437,Q96F86,Q9NUQ7,P23786,Q9Y487,Q6ZXV5,P50542,Q15392,Q13509 17 +Abnormal nephron morphology 0.5201587193946211 2.5429507966002727 0.0109920706721486 1.0 0.5734301342763595 57 Q9NZ08,Q9NPF4,P03886,Q14108,P00403,O43826,P23786,Q96AX1,P00846 9 +Muscle stiffness 0.6906736143389371 2.5316333589172046 0.01135326354775 1.0 0.5734301342763595 20 Q9Y3Z3,P07602,Q9NZJ7,P23786,Q15392,P49748,P00846 7 +Segmental peripheral demyelination remyelination 0.9260405650212752 2.5238921144990916 0.0116063541685214 1.0 0.5734301342763595 6 P00846,P03886 2 +Abnormal muscle fiber morphology 0.4960515176919071 2.51740351043887 0.0118223346494252 1.0 0.5734301342763595 64 Q9BPX6,Q9H2D1,P03886,P00403,P23786,P00846,Q99720,Q9Y223,Q70HW3 9 +Focal segmental glomerulosclerosis 0.6722987022532166 2.5038047994047252 0.0122865800009526 1.0 0.5734301342763595 21 P03886,Q14108,P00403,O43826,Q96AX1 5 +Specific learning disability 0.4922327406218315 2.4916991885504136 0.0127133658890976 1.0 0.5734301342763595 63 Q9BPX6,O00443,Q9BVA1,Q96DF8,P04350,P03886,P00403,Q9H6K4,Q9Y6X9,Q13509,P62266,P42858 12 +Urinary glycosaminoglycan excretion 0.9027869940278636 2.4555966613142637 0.0140650921026679 1.0 0.5734301342763595 7 O00443,P16278,P54802,P08236,Q96AX1,P15586 6 +Mental deterioration 0.5212836816094413 2.442627209566248 0.0145807899600922 1.0 0.5734301342763595 93 Q14108,O75503,Q9Y487,P00846,P42858,Q8NC96,Q09472,P04350,P16278,O15118,P03886,P00403,P05067,O43681,P50897,P54802,Q13510,P07602,Q05639,P04062,Q9NZJ7,Q9NPL8,O95470 23 +Elevated pulmonary artery pressure 0.6181093837885481 2.4363574343608265 0.0148360163980167 1.0 0.5734301342763595 24 P04062,P03886,Q14108,P00403,P49711,Q96AX1,O75844 7 +Airway obstruction 0.7191125428292214 2.4247620285036144 0.0153184243301924 1.0 0.5734301342763595 16 Q9Y223,P09601,O75844,Q96AX1 4 +Progressive gait ataxia 0.7785086453979515 2.416668352029024 0.0156632811271613 1.0 0.5734301342763595 11 P07602,O43681,Q9NZJ7,O14773,P00846 5 +Respiratory arrest 0.8953874572972025 2.401436788295425 0.0163308302987617 1.0 0.5734301342763595 6 P23786,P49748 2 +Abnormality of the phalanges of the toes 0.7365828139113397 2.394472652788534 0.0166442846014496 1.0 0.5734301342763595 14 Q96T60,P49711,P21281,Q6DKJ4,O75844,Q7LGA3 6 +Abnormality of pulmonary circulation 0.6053725593860937 2.389903521366672 0.016852799238064 1.0 0.5734301342763595 29 Q9NZ08,P04062,P03886,Q14108,P00403,P49711,Q96AX1,O75844 8 +Progressive visual loss 0.6781064462896467 2.388331338836468 0.0169250749518929 1.0 0.5734301342763595 19 P00846,O14773,P50897,P03886 4 +Neuronal loss in central nervous system 0.7477577263264958 2.3870887414110107 0.0169823914494453 1.0 0.5734301342763595 13 P07602,P37287,P04062,Q9NZJ7,O15118,P26358,P42858 7 +Ventricular preexcitation 0.8835884243208239 2.377914294158998 0.0174108721650114 1.0 0.5734301342763595 7 P00846,P10253,P03886 3 +Increased cerebral lipofuscin 0.9240716180371382 2.374817991503758 0.0175576054378423 1.0 0.5734301342763595 5 O75503,P07602,O14773,P50897 4 +Infantile muscular hypotonia 0.4851390098090384 2.3741318513830287 0.0175902678527795 1.0 0.5734301342763595 67 Q96T60,P07602,P10253,P27635,Q9BVA1,Q9Y5P6,P16278,Q9NZJ7,P03886,P21281,Q9Y487,P49748,P00846,Q13509,Q2TAA5 15 +Abnormal speech prosody 0.846615159098211 2.370917879085238 0.0177439730476247 1.0 0.5734301342763595 8 P00846,P03886 2 +Abnormal csf protein level 0.7416560577664372 2.3571124092134563 0.0184176707147003 1.0 0.5734301342763595 13 P07602,Q9NZJ7,O15382,P03886,Q9NR77,P00403,O43681 7 +Joint contracture of the hand 0.5302014843879574 2.3461519950251284 0.018968370422852 1.0 0.5734301342763595 51 P42892,Q15042,Q9NPF4,P16435,Q9NR77,P49711,P50542,Q15392,Q9Y6X9,Q6DKJ4,Q13509,Q8IZA0,O75844 13 +Abnormal retinal artery morphology 0.6174119393847177 2.338992337786029 0.0193358300454242 1.0 0.5734301342763595 23 P07602,P16278,P03886,P10619,P00846 5 +Fluctuations in consciousness 0.8731629590901133 2.335430677039483 0.0195209334120936 1.0 0.5734301342763595 7 P04062,P03886 2 +Abnormality of corneal stroma 0.7474981342530167 2.326281301282763 0.0200035488880312 1.0 0.5734301342763595 12 P04062,P16278,P50542,P10619,Q13510,Q12948 6 +Increased bone mineral density 0.6396434942787139 2.310216597242613 0.0208761656211764 1.0 0.5841484134858023 21 Q13126,P04062,P54802,Q14108,Q15392 5 +Abnormality of krebs cycle metabolism 0.8710964484569523 2.303133670637082 0.0212713233726395 1.0 0.5915762555037145 6 P00846 1 +Large basal ganglia 0.6811547140494157 2.279308158115702 0.0226487534209447 1.0 0.5952060279545501 17 Q08J23,Q2M389,Q96N66,Q9NZ01,Q9NUQ7,Q13509 6 +Abnormal renal cortex morphology 0.5260963917717045 2.271440688972085 0.0231203136079909 1.0 0.5962803379558621 50 Q9NZ08,Q9NPF4,P03886,Q14108,P00403,O43826,Q96AX1,P00846 8 +Amyotrophic lateral sclerosis 0.6877291771642751 2.2592791657317464 0.02386602505413 1.0 0.5962803379558621 16 Q15165 1 +Muscle spasm 0.48958837318608 2.2583474282657803 0.0239240075474991 1.0 0.5962803379558621 57 Q15165,P04062,Q9Y5P6,Q9NR77,P23786,Q9H6K4,P49748,Q9Y6X9,P00846 9 +Increased circulating antibody level 0.7062814904631892 2.2412866266061493 0.0250075146628634 1.0 0.5962803379558621 14 Q14108,P04062,Q96AX1 3 +Central scotoma 0.8152934390404878 2.2372547596348307 0.0252696942100956 1.0 0.5962803379558621 8 P00846,P03886 2 +Insidious onset 0.854668433613998 2.236017769390353 0.0253506072097098 1.0 0.5962803379558621 6 Q9NR77 1 +Abnormality of head blood vessel 0.5863682255525065 2.2332651736349987 0.0255314626991571 1.0 0.5962803379558621 25 P07602,P16278,P03886,P10619,P00846 5 +Broad phalanx of the toes 0.8508276041192542 2.2202527137316226 0.0264016178320329 1.0 0.5962803379558621 6 Q7LGA3,Q6DKJ4,P49711 3 +Nephropathy 0.6238037830893607 2.2147495191892923 0.0267772618815742 1.0 0.5962803379558621 21 Q14108,Q9NPF4,P00403,P03886 4 +Polyneuropathy 0.688399561073321 2.211998792299051 0.0269667483811049 1.0 0.5962803379558621 15 P07602,Q15120,Q9NZJ7,P04066,P03886,P00846 6 +Glomerular sclerosis 0.5759910920034134 2.2094473886988117 0.0271435379817306 1.0 0.5962803379558621 31 Q9NPF4,P03886,Q14108,P00403,O43826,Q96AX1 6 +Hand muscle weakness 0.7332563410153989 2.202047822619657 0.0276619305739527 1.0 0.5962803379558621 11 Q9NR77,Q9Y223,Q9Y6X9 3 +Abnormal circulating citrulline concentration 0.8798611929102728 2.200023703009867 0.0278052133615958 1.0 0.5962803379558621 5 P00846 1 +Avascular necrosis 0.6187800414718648 2.184256999541145 0.0289433686051772 1.0 0.5962803379558621 21 Q9NZ08,Q09472,P04062,Q14108,Q9NUQ7,O75844 6 +Hemiparesis 0.7065667218290732 2.182636601571829 0.0290625821229368 1.0 0.5962803379558621 13 Q9NZ08,P03886,Q9BVA1 3 +Deep plantar creases 0.841041748202878 2.17996022626464 0.0292604099405662 1.0 0.5962803379558621 6 Q09472,O00170,Q9Y487,P21281 4 +Hypothermia 0.7387464831311088 2.1761237155325386 0.0295460110453902 1.0 0.5962803379558621 10 P00846,P49748,P03886 3 +Retinopathy 0.575772179937141 2.167263328746042 0.0302147809919992 1.0 0.5970030432206221 26 P00846,P07437,Q9NZ08 3 +Abnormality of the septum pellucidum 0.5522179220582853 2.162294919125045 0.0305954511157771 1.0 0.5970030432206221 39 P37287,Q13363,P48651,P53701,Q9BVA1,Q2M389,Q8WWQ0,Q08J23,Q96N66,Q9NZ01,Q96F86,Q9NUQ7,Q15392,P43034,Q12904 15 +Diffuse white matter abnormalities 0.7623133653541315 2.150651377256744 0.0315037268524707 1.0 0.6049796886607792 9 Q96T60,P16278 2 +Gait ataxia 0.4627564285151493 2.1491372916460234 0.0316235184022497 1.0 0.6049796886607792 67 P07602,Q8IV08,P27635,P04350,Q9NZJ7,O14773,O15118,P03886,Q14108,Q9NR77,P00846,P42858 12 +Abnormality of the basal ganglia 0.4822473944536973 2.1401546454418763 0.032342271124091 1.0 0.6049796886607792 85 Q9BPX6,Q9Y3Z3,P04062,Q9BVA1,Q96N66,Q2M389,P16278,Q9NZ01,P03886,P00403,P23786,P00846,Q13509,P42858,Q96CU9 15 +Clumsiness 0.6342927387320978 2.1378614478275417 0.032527990012847 1.0 0.6049796886607792 19 P07602,Q9NZJ7,O14773,Q9NR77,O75503,O43681,P42858,Q13510 8 +Phenotypic variability 0.4977115379698213 2.1360865108223392 0.032672363042338 1.0 0.6049796886607792 100 P00374,Q9BVA1,Q9Y5P6,P00846,Q13885,Q9Y3Z3,Q09472,P04350,P03886,Q9NR77,P00403,P43034,Q70HW3,P35270,Q9BUF5,Q13509,P07602,Q9NZJ7,O95470 19 +Spinal muscular atrophy 0.7181947028374432 2.1294089623631227 0.0332204396040718 1.0 0.6049796886607792 11 Q9Y6X9,Q99720,Q13510 3 +Ventricular arrhythmia 0.5551399527362482 2.128530596345175 0.0332931159512948 1.0 0.6049796886607792 36 P10253,P42892,P03886,P23786,P49748,Q96AX1,P00846,O43772 8 +Abnormal caudate nucleus morphology 0.7262261394729959 2.116834142276011 0.0342739265923084 1.0 0.6109095874004657 10 P00846,Q9BVA1 2 +Blurred vision 0.859068545761861 2.116654759371493 0.0342891590384826 1.0 0.6109095874004657 5 P00846 1 +Mucosal telangiectasiae 0.7241185472901545 2.1068147118905474 0.0351336437416209 1.0 0.6142384705149275 10 Q13315,P12004,P19447,P10619,Q14739,Q8IZA0,P06280 7 +Centrocecal scotoma 0.942355655764088 2.1033010443345814 0.0354394622255029 1.0 0.6142384705149275 4 P00846 1 +Scotoma 0.7119949537745375 2.099334900873983 0.0357873889013697 1.0 0.6142384705149275 11 P00846,P03886 2 +Postural instability 0.6374418943940945 2.094568946854636 0.0362093280841604 1.0 0.6142384705149275 18 Q9NR77,O75503,P04062 3 +Focal onset seizure 0.4673334615427204 2.090333631880458 0.0365878401504393 1.0 0.6160013799152559 76 Q9UBX3,Q9BVA1,Q9NZ01,O75503,P27635,Q2M389,P03886,P00403,Q6ZXV5,P43034,Q08J23,Q96F86,Q9NUQ7,Q13509,Q96T60,P07602,Q96N66,Q9NZJ7,P21281 19 +Abnormal temper tantrums 0.7189151282953892 2.0820298525630423 0.0373397430381663 1.0 0.6261270882245467 10 P04062,Q9BVA1 2 +Slow decrease in visual acuity 0.8081423265992638 2.0657282157550307 0.0388541495082939 1.0 0.6491347102832546 7 P00846 1 +Corneal opacity 0.5097205270525852 2.0610132891004285 0.0393017722901221 1.0 0.6518377578736252 48 Q13363,P08236,P10619,Q09472,P16278,P49454,P04066,Q16625,O75844,P06280,Q12948,P51648,O15111,Q13510,P53701,P04062,O14802,O43684,P50542,P19447,Q9H3P2 21 +Abnormal renal tubule morphology 0.5602383266758328 2.0549561321709353 0.0398832419959565 1.0 0.6570839147662424 24 P00846,P23786,P03886,Q96AX1 4 +Myoglobinuria 0.7394992507004707 2.046752853703141 0.0406823568858505 1.0 0.6570839147662424 9 P23786 1 +Retinal telangiectasia 0.8408324182637202 2.04293633796944 0.0410587405631175 1.0 0.6570839147662424 5 P00846 1 +Abnormal corpus striatum morphology 0.6466497978944724 2.0377847168745693 0.0415714674524665 1.0 0.6606531813613237 16 P00846,P42858,Q9BVA1 3 +Nasogastric tube feeding 0.5569200194778192 2.032603199152335 0.0420926280421267 1.0 0.6630810137199001 24 Q08J23,Q2M389,Q96N66,Q9NZ01,Q96F86,Q9NUQ7 6 +Splenomegaly 0.4715725478344755 2.0319335829984495 0.0421603801751306 1.0 0.6630810137199001 85 Q9NZ08,P10253,O00443,P07602,P28070,P04062,Q9NZJ7,P16278,O15118,P54802,P21281,Q14108,P08236,Q15392,Q96AX1,Q14739,P15586,Q9Y223 18 +Peripheral demyelination 0.6260426385254463 2.0295515057247666 0.0424021485006993 1.0 0.6645917502119921 18 P07602,Q9NZJ7,P03886,Q9NR77,P00846 5 +Pericardial effusion 0.8366882457835254 2.026106793316992 0.0427538421053168 1.0 0.6661422851018799 5 Q14108,P04062,P49748 3 +Hemianopia 0.803927104520307 2.0255220373530074 0.0428137879324643 1.0 0.6661422851018799 6 P00403,P03886,Q9BVA1 3 +Hypoketotic hypoglycemia 0.7983241554589274 2.02430061080291 0.0429392308309477 1.0 0.6661422851018799 7 P23786,P49748 2 +Motor neuron atrophy 0.5915389474697358 2.017126019642885 0.043682363930692 1.0 0.673092100972589 21 Q15165 1 +Positive romberg sign 0.7309132910154573 2.0073430437091755 0.0447131489087124 1.0 0.6741552402980324 9 Q96RR1,Q9H6K4,Q8IV08 3 +Heparan sulfate excretion in urine 0.9171362280410992 2.007339960690268 0.0447134769578001 1.0 0.6741552402980324 4 P54802,P08236,Q96AX1 3 +Hemiplegia hemiparesis 0.5478179201367576 2.0014528739895434 0.045343607521874 1.0 0.6741552402980324 30 Q9NZ08,Q9Y3Z3,Q9BVA1,Q9NPF4,P03886,P00403 6 +Abnormal pericardium morphology 0.7287740327999137 1.9974978245176325 0.0457711305500374 1.0 0.6741552402980324 9 Q14108,Q9NZ08,P04062,P49748 4 +Toe walking 0.5642899939854265 1.9964780289716657 0.0458819149342981 1.0 0.6741552402980324 23 P07602,Q86UE8,Q9NZJ7,Q9Y6X9,Q99720 5 +Rhabdomyolysis 0.6804924271201986 1.996163156046415 0.0459161664168918 1.0 0.6741552402980324 12 P23786,P49748 2 +Supranuclear gaze palsy 0.628468489974532 1.9882014149447096 0.046789418566687 1.0 0.6741552402980324 17 P07602,Q99720,O15118,P04062 4 +Capillary hemangioma 0.7893165228931526 1.9861345720016483 0.0470183834007786 1.0 0.6741552402980324 7 Q15436,Q09472,P21281,P16435,Q9UHX1,Q7LGA3 6 +Psychotic mentation 0.7927923307867666 1.978696995777531 0.0478501314162476 1.0 0.6741552402980324 6 P00403,P03886 2 +Eyelid myoclonus 0.7559583907924705 1.978376648487028 0.0478862320482318 1.0 0.6741552402980324 8 P00374,Q13510 2 +Limited wrist movement 0.823801491420999 1.9735942617805975 0.0484278967440783 1.0 0.6741552402980324 5 Q9H6K4,O75844 2 +Cerebral inclusion bodies 0.6541672669150131 1.971350702243028 0.0486837756657401 1.0 0.6741552402980324 14 O15118,P04062 2 +Visual loss 0.5094836062977465 1.9685926465693593 0.0489998876735395 1.0 0.6741552402980324 45 P07602,P50897,Q9NZJ7,O14773,P03886,P00403,O75503,P00846,Q13509,O00170,Q12948 11 +Neck muscle weakness 0.6530895125733351 1.9656827821133305 0.0493352649332476 1.0 0.6741552402980324 14 Q9Y6X9,Q9NZJ7,P07602,Q99720 4 +Abnormal urine protein level 0.4728778740641446 1.9604265365533136 0.0499459567336373 1.0 0.6741552402980324 54 P04062,P09601,Q9NPF4,P03886,Q14108,P00403,O43826,Q96AX1 8 +Mitochondrial respiratory chain defects 0.788310507013469 1.959786855363169 0.0500207082485071 1.0 0.6741552402980324 6 P00846 1 +Equinovarus deformity 0.8196539529947495 1.9566363257321768 0.0503902409939833 1.0 0.6741552402980324 5 Q9NR77 1 +Generalized clonic seizure 0.7873222394864143 1.9556122582410005 0.0505108477569984 1.0 0.6741552402980324 6 Q96T60,P07602 2 +Abnormal vascular physiology 0.4851109843893199 1.9522846120952704 0.0509044233579218 1.0 0.6741552402980324 51 Q9NZ08,O00443,Q9Y3Z3,P04062,P49711,Q14108,P03886,P00403,O43826,P05067,Q96AX1,Q14739,O75844 13 +Glomerulopathy 0.6912836285379869 1.9492830714419271 0.0512616290873868 1.0 0.6741552402980324 10 Q14108 1 +Osteoarthritis 0.7179662883911849 1.9476018320082933 0.0514626243907354 1.0 0.6741552402980324 9 Q14108,O75844,Q9NUQ7,P04062 4 +Abnormal morphology of the conjunctival vasculature 0.747858437554373 1.9424726498498348 0.0520799078082299 1.0 0.6741552402980324 8 P04066,Q13315,P12004,P10619,P06280 5 +Episodic vomiting 0.6685306458427462 1.935940823225481 0.0528749491236857 1.0 0.6741552402980324 12 P00403,P00846,P49748,P03886 4 +Decerebrate rigidity 0.8972489227709618 1.9310752036314127 0.0534737529686344 1.0 0.6741552402980324 4 Q9NZJ7,P16278,P07602 3 +Memory impairment 0.533791330556251 1.9301431940930471 0.0535890977631228 1.0 0.6741552402980324 33 Q9NR50,Q9NZ08,P07602,Q9NZJ7,P03886,P00403,P43246,P26358,P05067,P42858,P52701,O43681,Q96RR1,P49770,Q9Y223 15 +Periventricular white matter hyperintensities 0.7447167155018211 1.928511105860122 0.0537915842032632 1.0 0.6741552402980324 8 Q9NZJ7,P07602,O75503,P27635 4 +Ovoid vertebral bodies 0.7804561500166018 1.9265612324146133 0.0540343339309936 1.0 0.6741552402980324 6 P16278,P54802 2 +Abnormal circulating non proteinogenic amino acid concentration 0.7417244368331539 1.9151953743816257 0.0554675921814817 1.0 0.6843252503239647 8 P00846,P03886 2 +Absent septum pellucidum 0.5343569366533271 1.9140264275982997 0.0556167790669983 1.0 0.6843252503239647 31 P37287,Q13363,P48651,P53701,Q08J23,Q2M389,Q96N66,Q9NZ01,Q96F86,Q9NUQ7,Q15392,Q12904 12 +Parkinsonism with favorable response to dopaminergic medication 0.7095567149253307 1.908597968609388 0.0563139741927938 1.0 0.6852481626609538 9 P07602,P04062 2 +Pulmonary infiltrates 0.7758107094709137 1.9068591429100117 0.0565388301793647 1.0 0.6854346894091388 6 Q9NZ08,P04062 2 +Pedal edema 0.7380824194091326 1.8989643334453448 0.0575691656268058 1.0 0.6946374720207971 8 Q14108 1 +Abnormal peripheral myelination 0.5329831471332613 1.8828240372625795 0.0597242183868365 1.0 0.7149662993762763 28 P07602,Q9NZJ7,P03886,Q9NR77,Q9Y6X9,P00846 6 +Mitochondrial inheritance 0.8007248979366051 1.8788969843508192 0.0602585607033485 1.0 0.7194745952041173 5 P00846,P03886 2 +Cherry red spot of the macula 0.7001396006319636 1.864737591657496 0.0622181948202253 1.0 0.7332743839148528 9 Q9NZJ7,P07602,P16278,P10619 4 +Mixed demyelinating and axonal polyneuropathy 0.8789111757712819 1.8603105911287845 0.0628415959752901 1.0 0.735205686148558 4 P00403,P03886 2 +Flared iliac wing 0.7646254189980389 1.8592678057346397 0.0629891879447213 1.0 0.735205686148558 6 P16278,Q96AX1 2 +Aortic valve stenosis 0.6727099852906431 1.8590020957410849 0.0630268413251669 1.0 0.735205686148558 10 O75844,P16278,P04062 3 +Abnormality of salivation 0.5073894796197018 1.8557054402248372 0.063495554962494 1.0 0.7370826582062425 41 Q9NR77,Q15165,Q9BVA1 3 +Acetabular dysplasia 0.7276514763077824 1.852333811899903 0.0639779032802758 1.0 0.7387423211679449 8 P16278,P08236 2 +Abnormality of femur morphology 0.4288169760133615 1.8479431258489676 0.0646105708933126 1.0 0.740579211862455 63 O00443,P07602,Q09472,P04062,Q96AY3,Q9NZJ7,P16278,P04066,P16435,P50542,Q9NUQ7,Q9Y487,Q14739,O75844,Q7LGA3 15 +Sensorimotor neuropathy 0.527228924641958 1.847849613259034 0.0646241013640116 1.0 0.740579211862455 29 Q96T60,P07602,Q15120,Q9Y2R0,Q9NZJ7,P03886,P00403,Q9NR77,P00846 9 +Delayed puberty 0.4686286828800237 1.8412597154652703 0.0655835081454885 1.0 0.7454768655492221 52 Q15233,P04062,P27635,Q15042,P16435,Q14108,Q13315,Q13045,O43826,Q15800,O75844,P63241,O00170,Q8IWS0 14 +Abnormal placenta morphology 0.6944633870164728 1.8382083093055284 0.0660317158511452 1.0 0.7454768655492221 9 P16278 1 +Bruising susceptibility 0.5255415519971811 1.8358165823315835 0.0663847881390338 1.0 0.7454768655492221 29 Q13126,P04062,Q14108,O43826,Q8NCH0,P49257,O00170 7 +Abnormalities of placenta or umbilical cord 0.6176596442048297 1.8337090340324889 0.0666971968843344 1.0 0.7454768655492221 15 P16278,O75844,P21281 3 +Demyelinating peripheral neuropathy 0.6002320438182156 1.8283583816092008 0.0674957831647999 1.0 0.7454768655492221 17 Q9NR77,P00846,P03886 3 +Abnormal morphology of the musculature of the neck 0.6372455735665951 1.8275921529226864 0.0676107843675857 1.0 0.7454768655492221 13 P04350,Q99720 2 +Abnormal neuron morphology 0.5262447021890357 1.8272730136081257 0.0676587306594187 1.0 0.7454768655492221 26 Q15165 1 +Progressive spastic quadriplegia 0.7200947083435832 1.818420849458392 0.0689998340878339 1.0 0.7457902390434155 8 P07602,Q9NZJ7,P43034,O43681,Q9Y263 5 +Biliary cirrhosis 0.7545825177936353 1.8163570365468524 0.0693156211870418 1.0 0.7457902390434155 6 Q14739,P09601 2 +Sporadic 0.5242570391037163 1.8133898502725856 0.0697717138884206 1.0 0.7470159320307195 26 Q9BWD1,P48651,Q09472,P42345,P04062,P04350,P43034 7 +Extrapyramidal muscular rigidity 0.7836791034468742 1.8084234060090816 0.0705406277926323 1.0 0.747693464448446 5 Q9BPX6,Q9H6K4 2 +Abnormal basal ganglia mri signal intensity 0.5224199404344372 1.8081060189484857 0.0705900015996903 1.0 0.747693464448446 28 P00846,P16278,P03886,Q96CU9 4 +Abnormality of the larynx 0.4867419215166441 1.8062404202088524 0.0708807937563626 1.0 0.747693464448446 46 Q9UBM7,Q8NCM8,Q15165,Q14739,Q96HY6,Q09472,P27635,P16435,P07737,P43246,Q92804,P52701,Q13510,P07602,Q92766,Q69YQ0,Q9NZJ7,O14802,Q9UHX1,Q92890 20 +Biliary tract neoplasm 0.8649157127321203 1.8060311546653751 0.0709134733030492 1.0 0.747693464448446 4 Q9NZJ7,P07602 2 +Neoplasm of the gallbladder 0.8649157127321203 1.8060311546653751 0.0709134733030492 1.0 0.747693464448446 4 Q9NZJ7,P07602 2 +Optic neuropathy 0.5466676434936746 1.8043405665150336 0.0711779340104534 1.0 0.7480243249347425 22 P00846,Q9Y6M9,P03886,Q96CU9 4 +Psychomotor deterioration 0.6850472027291731 1.79404917503209 0.0728053202529706 1.0 0.7616171231050433 9 Q9NZJ7,P07602,P50897 3 +Oligosacchariduria 0.7777181780059649 1.7836780919412838 0.0744759880397745 1.0 0.7649324242838695 5 P10253,P16278 2 +Fibrous tissue neoplasm 0.6179784709512659 1.77920321664362 0.0752064512170382 1.0 0.7690955695087704 14 Q13126,P21281 2 +Abnormality of extrapyramidal motor function 0.4279017278214841 1.7775457988406207 0.0754784825025305 1.0 0.7701506905906974 68 Q9BPX6,Q9Y3Z3,P07602,P04062,P11802,Q9NZJ7,P16278,P35270,Q96IX5,P05067,Q9H6K4,O14949,Q99720,P42858 14 +Exercise induced muscle cramps 0.7447831294115373 1.774327084859482 0.076009062969768 1.0 0.7703940804558047 6 P23786 1 +Bilateral ptosis 0.6268031351585526 1.7729604263170236 0.076235264594854 1.0 0.7709734851821052 13 Q13509,Q9Y5P4 2 +Disinhibition 0.4525856374802307 1.7708002433098775 0.0765939254775196 1.0 0.7719637772796264 54 Q8NC96,Q15233,Q09472,P04062,Q08J23,Q2M389,Q96N66,Q9NZ01,Q96F86,P05067,Q9NUQ7,Q8TAA9,P42858 13 +Abnormality of the musculature of the lower limbs 0.5181084768870925 1.770332945676417 0.0766716928541264 1.0 0.7719637772796264 26 Q9NR77,P00846,Q9Y223 3 +Metatarsus adductus 0.6244200631761837 1.760452978761256 0.0783310334028219 1.0 0.7840472755391924 13 P50542,Q13509,P08236,Q15392 4 +Abnormality of the alveolar ridges 0.7714315154733544 1.7575259304076185 0.0788282060033853 1.0 0.7840472755391924 5 P21281 1 +Eeg with spike wave complexes 0.6238069764659839 1.7572328523806993 0.0788781277329018 1.0 0.7840472755391924 13 Q14108,Q96T60,O75503,P43034 4 +Parkinsonism 0.5161354742117749 1.7564812676256472 0.0790062672074802 1.0 0.7840472755391924 26 P07602,P05067,Q99720,P04062 4 +Upper airway obstruction 0.7703302169710572 1.7529389172788703 0.0796124925114232 1.0 0.7842604283900675 5 O75844,Q9Y223 2 +Abnormal lower motor neuron morphology 0.7345362779502962 1.7508867561433772 0.0799654185265197 1.0 0.785245821897417 7 Q99720 1 +Abnormal saccadic eye movements 0.5155282577933127 1.7503562914915027 0.0800568531423588 1.0 0.785245821897417 25 Q13509,O14773,Q8IV08,P04062 4 +Hypoparathyroidism 0.6122765303465753 1.7485936827855713 0.0803612790578609 1.0 0.7865403300062312 14 Q96DF8,P00403,P03886 3 +Pathologic fracture 0.610929331012536 1.741348746192482 0.0816224664777214 1.0 0.7971735965843414 14 Q13126,Q14108 2 +Abnormal circulating lipid concentration 0.4263182481687199 1.736937998336109 0.082398115393663 1.0 0.7977380968417206 70 P07602,P28070,O75880,Q9NZJ7,Q7L590,P22830,Q15800,O95470,O43826,P23786,P50542,Q15392,P49748,Q14739,O43772,P42858,O75844 17 +Abnormal pulmonary interstitial morphology 0.5108191885599507 1.7361924722406397 0.0825298078625684 1.0 0.7977380968417206 30 P04062,P09601,Q14108,Q8IZA0,Q13510 5 +Cardiac conduction abnormality 0.5116212780291804 1.7360511735479724 0.0825547866058522 1.0 0.7977380968417206 29 P03886,P23786,P49748,P00846,O43772 5 +Broad columella 0.7659692067623919 1.7347585540015698 0.0827835801084313 1.0 0.7982577354641762 5 O00443 1 +Movement abnormality of the tongue 0.8446510882124758 1.7270473963711692 0.0841591517180395 1.0 0.8090333123797494 4 P04350 1 +Cerebral visual impairment 0.41985890589799 1.72482953178441 0.0845581979884595 1.0 0.8098520553988421 60 Q05639,Q08J23,Q2M389,Q96N66,Q15042,P03886,Q9NZ01,P00403,Q96F86,Q9NUQ7,Q96RR1,Q9Y5P4,Q96CU9 13 +Emg chronic denervation signs 0.62609864336612 1.71931430435384 0.0855571567143351 1.0 0.8098520553988421 12 O43681,P07602,Q9NZJ7,Q13510 4 +Endocarditis 0.8423351792104891 1.7179930655073778 0.0857978801345751 1.0 0.8098520553988421 4 Q9NZ08 1 +Bruxism 0.6973390571815236 1.7156571387628672 0.0862248138886685 1.0 0.8098520553988421 8 Q9Y5P4,P42858 2 +Migraine 0.5714797386362953 1.7121765287024555 0.0868641415090945 1.0 0.8098520553988421 18 Q9NZ08,P03886,P00403,P05067,Q96RR1,O00170 6 +Abnormal pupillary function 0.7603431337875557 1.7112664334632095 0.0870319398240679 1.0 0.8098520553988421 5 Q9NR77,P07602 2 +Microcytic anemia 0.6961922269354573 1.7104534390256616 0.0871820563913245 1.0 0.8098520553988421 8 P22830,Q9UBX3 2 +Chronic fatigue 0.728816342745727 1.7055202959972486 0.0880974302921842 1.0 0.8126891417460955 6 P07602 1 +Stillbirth 0.632552196923219 1.7052810564579846 0.0881420188923642 1.0 0.8126891417460955 11 O75844,Q14739,P04062,P16435 4 +Clonic seizure 0.7237452676193765 1.7039462468148827 0.0883911299743527 1.0 0.8126891417460955 7 Q96T60,P07602 2 +Personality changes 0.5864892180494233 1.703672034877684 0.0884423754410759 1.0 0.8126891417460955 16 P42858,P04062,P03886 3 +Basal ganglia calcification 0.694563994928045 1.703061460294224 0.0885565672983577 1.0 0.8126891417460955 8 Q9Y3Z3,P03886 2 +Visual field defect 0.4960303945680067 1.6970294376557038 0.0896910952155292 1.0 0.8151977734216109 37 Q9BVA1,Q6UX04,P03886,P00403,Q9H6K4,P00846 6 +Neurofibrillary tangles 0.8369345564071627 1.6968575913629416 0.08972358742768 1.0 0.8151977734216109 4 O15118 1 +Deep palmar crease 0.6291901521526289 1.6882682749839393 0.0913597422817051 1.0 0.8208114760276091 11 P42345,P21281,Q9Y487,Q96AX1,O00170 5 +Abnormal oral mucosa morphology 0.4437938619314817 1.6877442839005583 0.0914603270398328 1.0 0.8208114760276091 54 Q9NZ08,P04062,P16278,P21281,Q14108,O43826,P08236,Q15392,Q14739,Q6DKJ4 10 +Increased serum pyruvate 0.500951379244103 1.68736292731096 0.0915335877858745 1.0 0.8208114760276091 33 Q9BWD1,Q9Y6M9,Q86Y39,P03886,Q70HW3,Q96CU9 6 +Abnormal acetabulum morphology 0.5576839689427762 1.6830955101876195 0.0923566035193423 1.0 0.8243414259329171 19 Q8NCM8,Q96AY3,P16278,Q9NUQ7,P08236,Q96AX1,P62244,O75718 8 +Retinal vascular tortuosity 0.5825141609162218 1.6812121447379231 0.092721715373508 1.0 0.8243737696268424 16 P00846,P03886 2 +Abnormality of skull ossification 0.6089251106604601 1.6787772556553735 0.0931954628758853 1.0 0.8258007325398803 13 O75844,O75718,P54802,Q14739 4 +Abnormality of the wrist 0.5042661661259402 1.6785266754241406 0.0932443273970704 1.0 0.8258007325398803 28 Q9Y223,P16278,P16435,Q9NUQ7,Q9H6K4,Q13509,O75844 7 +Hypoplastic vertebral bodies 0.7215653677412008 1.674146028411424 0.094101903585493 1.0 0.8280798710799656 6 Q14739,P16278,O14802,Q8TAA9 4 +Supernumerary tooth 0.6875787255184336 1.6712974808705467 0.0946629337816102 1.0 0.8280798710799656 8 Q09472,P21281,Q9UHX1,P62266,Q6DKJ4 5 +Ectopic anus 0.6074009468790362 1.6707111070118272 0.0947787539329134 1.0 0.8280798710799656 13 Q8NCM8,P48651,P53701,P16435,P49748,Q6DKJ4 6 +Perisylvian polymicrogyria 0.750579477705094 1.6703993253281273 0.0948403830538078 1.0 0.8280798710799656 5 Q15042,Q9BVA1 2 +Disproportionate short stature 0.514935201415148 1.6671715932013058 0.0954802895137354 1.0 0.8280798710799656 23 Q9UBM7,Q8NCM8,P42345,Q14739,O75718,O00116,P16278,Q9UHX1,Q15392,Q96HY6,Q6DKJ4,Q7LGA3 12 +Sensory ataxia 0.749208395009316 1.664650791295852 0.0959824458075493 1.0 0.8280798710799656 5 Q9NR77,P54802 2 +Beaking of vertebral bodies 0.7139166204660874 1.661034215967929 0.0967065750067233 1.0 0.8280798710799656 7 P16278,P08236 2 +Neurodegeneration 0.5011375626467824 1.6603501284832938 0.0968440366949419 1.0 0.8280798710799656 29 Q15165,P08236,P42858 3 +Abnormality of the phalanges of the hallux 0.8269283454686385 1.6576228537457829 0.0973936138790896 1.0 0.8280798710799656 4 Q6DKJ4,P49711 2 +Sea blue histiocytosis 0.9854256376283538 1.657594981132667 0.0973992433732098 1.0 0.8280798710799656 2 P16278 1 +Lacticaciduria 0.7171501498196237 1.6550045517931329 0.0979235745941746 1.0 0.8280798710799656 6 P00846,P03886 2 +Leber optic atrophy 0.9847631666114608 1.6549683136012814 0.0979309255635141 1.0 0.8280798710799656 2 P00846 1 +Multiple glomerular cysts 0.9847631666114608 1.6549683136012814 0.0979309255635141 1.0 0.8280798710799656 2 P00846 1 +Retinal arterial tortuosity 0.9847631666114608 1.6549683136012814 0.0979309255635141 1.0 0.8280798710799656 2 P00846 1 +Low plasma citrulline 0.9847631666114608 1.6549683136012814 0.0979309255635141 1.0 0.8280798710799656 2 P00846 1 +Abnormal iliac wing morphology 0.6131789977432643 1.652477745299582 0.0984371982163123 1.0 0.8280798710799656 12 Q09472,P16278,P50542,Q96AX1,Q8TAA9 5 +Thickened ribs 0.8254059626487901 1.651645291504295 0.0986068813513314 1.0 0.8280798710799656 4 P16278,P54802 2 +Inflammation of the large intestine 0.6129788131165619 1.6514391206408725 0.0986489422308156 1.0 0.8280798710799656 12 P08183,P49748 2 +Abnormal tongue physiology 0.5683660827331297 1.6449517536246616 0.0999797609188564 1.0 0.8310832076371744 17 P10253,P04350,Q16637,Q9BQT8,Q13510 5 +Delusions 0.5682847346805477 1.6444797037182106 0.1000771533465414 1.0 0.8310832076371744 17 P07602,P04062,Q96DF8,Q9NZJ7,P42858 5 +Abnormal larynx morphology 0.4992740497597303 1.6426462619705955 0.100456143211133 1.0 0.8310832076371744 28 P07602,Q8NCM8,Q09472,Q92766,P27635,Q69YQ0,Q9NZJ7,O14802,P16435,Q92890,Q96HY6,Q9UHX1,Q14739,Q13510 14 +Poor head control 0.4150682968662319 1.6424997535938033 0.1004864771813023 1.0 0.8310832076371744 68 Q8NC96,P00374,Q96T60,P07602,Q15233,Q05639,Q9Y5P6,Q9NZJ7,Q9Y6M9,Q86Y39,P03886,P43034,Q96CU9 13 +Abnormal diaphysis morphology 0.4119226619453388 1.6422301482612147 0.1005423169599808 1.0 0.8310832076371744 60 Q13126,O75718,Q96AY3,P16278,P16435,Q9NR77,Q9NUQ7,P08236,Q9Y487,Q14739,Q13509,Q7LGA3 12 +Nonimmune hydrops fetalis 0.4985255842337359 1.6321182933378655 0.1026545687593289 1.0 0.8385957540157536 26 P04062,O75879,Q7L590,P61254,P61313,Q9BT22,P10619,P62244,Q14739,P18077 10 +Abnormal oral physiology 0.4416680506592439 1.6294108133391398 0.1032260811885796 1.0 0.8398109198334895 53 Q9NR77,Q15165,Q9Y5P4,Q9BVA1 4 +Temporal pattern 0.6783221255434222 1.629079498047443 0.1032961907534724 1.0 0.8398109198334895 8 Q9NR77 1 +Loss of speech 0.5714679145374032 1.6185686001550517 0.1055401156627091 1.0 0.8504743242714071 16 Q9Y3Z3,P07602,P50897,Q9NZJ7,O15118 5 +Tube feeding 0.4092178412156048 1.6139692663567762 0.1065340927761633 1.0 0.8569700126138994 60 P07602,Q15233,Q09472,Q08J23,Q2M389,Q96N66,Q9NZJ7,P49711,Q9NZ01,Q96F86,Q9NUQ7,Q99720 12 +Emg neuropathic changes 0.5171543711819447 1.6108390873848608 0.1072147992201559 1.0 0.8594444076064476 22 P07602,Q9NZJ7,O14773,Q9NR77,O43681,Q13510 6 +Soft tissue sarcoma 0.4952631128122096 1.6108218216496686 0.1072185634571516 1.0 0.8594444076064476 27 P63167,Q13126,Q9UPY3,Q09472,P21281,P52701,Q15392 7 +Abnormality of the odontoid process 0.7057819963162726 1.6055953171044963 0.1083628550613016 1.0 0.8622159553177946 6 P16278 1 +Hydrops fetalis 0.4736955874082694 1.60368830794836 0.10878277439057 1.0 0.8627782703032756 42 P37287,Q8NCM8,P04062,O75879,P16278,Q7L590,P61254,P61313,Q9BT22,P08236,P10619,P62244,Q14739,P18077,Q13510 15 +Ragged red muscle fibers 0.5442850483622828 1.6015168239967237 0.1092624967529054 1.0 0.8627782703032756 19 Q9H2D1,P03886,P00403,P00846,Q70HW3 5 +Oral ulcer 0.6997349108293895 1.5988659465621549 0.1098503920354327 1.0 0.8632553859072938 7 Q9NZ08 1 +Dermal atrophy 0.4938085609282246 1.597801103017439 0.1100872490993962 1.0 0.8632553859072938 25 P53701,Q15334,Q15392,Q8NCH0,O00170,O75844 6 +Hypoplasia of the odontoid process 0.7332317173927049 1.5974991309234632 0.1101544912514898 1.0 0.8632553859072938 5 P16278 1 +Mitochondrial myopathy 0.4918241685039454 1.5861699812626415 0.1127007553966963 1.0 0.8714362637728328 27 Q9Y6M9,Q86Y39,P03886,P00846,Q96CU9 5 +Oculomotor apraxia 0.4917985645576471 1.5835885448178035 0.1132873824137254 1.0 0.8717838492031328 25 Q96T60,P04062,Q7Z460,O14773,P05067,Q13509 6 +Intestinal pseudo obstruction 0.6668268638159909 1.5764615809662792 0.1149194660962251 1.0 0.8717838492031328 8 P00403,P03886 2 +Arthritis 0.4678290266020409 1.5755508103140423 0.1151293599712588 1.0 0.8717838492031328 43 Q9NZ08,Q9Y3Z3,P28070,P04062,Q14108,O43826,Q9NUQ7,Q14739,O00170,O75844 10 +Abnormality of the gingiva 0.4676463561246812 1.5740329834636906 0.1154798242959651 1.0 0.8717838492031328 43 P04062,P16278,P21281,Q14108,O43826,P08236,Q15392,Q14739,Q6DKJ4 9 +Headache 0.4052148284199273 1.572046716414926 0.1159397173660818 1.0 0.8717838492031328 60 Q9NZ08,Q9Y3Z3,P04062,O15382,P03886,P00403,P23786,P05067,Q8TAA9,P00846,Q96RR1,O00170 12 +Agnosia 0.7268525266840936 1.570605830454609 0.1162742348340204 1.0 0.8717838492031328 5 P43246,P05067,P52701 3 +Impaired vibration sensation in the lower limbs 0.5971447883184582 1.5690087485844206 0.1166459005181979 1.0 0.8721671348581977 12 P00846 1 +Generalized onset seizure 0.441035959412307 1.564161707837791 0.1177795973161797 1.0 0.8759051896477655 99 P00374,Q9NZ01,Q14108,O75503,P00846,P27635,Q2M389,P16278,P03886,P43034,Q08J23,Q96F86,Q9NUQ7,Q13510,Q96T60,P07602,P04062,Q96N66,Q9NZJ7 19 +Respiratory distress 0.4384117279471115 1.5632347733359906 0.1179973838787178 1.0 0.8759051896477655 52 P07602,P10253,Q09472,P04062,P04350,Q9NZJ7,P03886,P21281,P23786,P49748,Q96AX1,P00846,Q13510 13 +Wide nasal ridge 0.8025893342517829 1.561818687548951 0.1183307081262736 1.0 0.8759051896477655 4 O14802,P27635 2 +Impaired proprioception 0.4785610755456993 1.5610992091823146 0.1185003446603449 1.0 0.8759051896477655 37 Q8IV08,O14773,P54802,Q9NR77,Q9H6K4,P00846 6 +Broad ribs 0.8023535513027136 1.560888275428507 0.1185501141450575 1.0 0.8759051896477655 4 P16278 1 +Gingival fibromatosis 0.9609142100033125 1.5603289030381156 0.1186821765407408 1.0 0.8759051896477655 2 P21281 1 +Excessive salivation 0.487912088718598 1.556563332318312 0.1195741952037166 1.0 0.880116604671766 26 Q9NR77,Q9BVA1 2 +Abnormal conjunctiva morphology 0.4873158221562941 1.5562917160932683 0.1196387403851118 1.0 0.880116604671766 28 Q9NZ08,P37287,P28070,P02786,P50851,P04066,Q13315,P12004,P19447,P10619,Q96AX1,Q14739,Q13510,P06280 14 +Broad based gait 0.5086599146988685 1.5545693634165438 0.1200486649731928 1.0 0.881710082033386 22 Q9Y5P4,O14773,P42858,P04062 4 +Distal lower limb muscle weakness 0.5271997467545648 1.550947999607554 0.1209141461565275 1.0 0.8852048107529151 20 Q96T60,Q9NR77,Q9Y6X9,P00846,Q9Y223 5 +Severe short stature 0.5176058327611495 1.5490696060590976 0.1213649883632939 1.0 0.8856731390799736 21 P16278,P10619 2 +Abnormality of thalamus morphology 0.5659615471948043 1.5479105196481238 0.1216438415373057 1.0 0.8858755109040698 15 Q9Y5P6,O00443,Q13509 3 +Synostosis involving digits 0.7988630671915222 1.5471099434727222 0.1218367366172583 1.0 0.8858755109040698 4 Q15233 1 +Episodic respiratory distress 0.9781944286287584 1.5458693360896776 0.1221361274932868 1.0 0.8858755109040698 3 P00846 1 +Young adult onset 0.608965375914864 1.543258772312833 0.1227680024147681 1.0 0.8858755109040698 10 Q9NZJ7,P07602,O15118,Q14566 4 +Agitation 0.4792129164768881 1.542610130689651 0.1229253985334044 1.0 0.8858755109040698 35 P42892,Q15165,P42858,P04062 4 +Diaphragmatic weakness 0.7977015417817552 1.5425230278899502 0.1229465464596089 1.0 0.8858755109040698 4 Q9NR77,P10253 2 +Hyperlipidemia 0.4846164332086302 1.540137533055654 0.1235268325935585 1.0 0.8872533597783002 29 P28070,P35573,P28340,Q7L590,P22830,O95470,O43826,Q13045,P23786,P49257,O75844 11 +Absent thumbnail 0.7948570216441473 1.5312859866456026 0.1256987273726464 1.0 0.8888423083690973 4 P21281 1 +Abnormality of the antihelix 0.6062997172028919 1.5298774297851 0.1260470710362731 1.0 0.8888423083690973 10 P16435,Q15042,P27635 3 +Difficulty walking 0.403250447877226 1.5291836288979406 0.1262189278870487 1.0 0.8888423083690973 67 Q8NC96,Q9BPX6,Q9Y3Z3,P07602,Q15120,Q05639,O43681,Q9Y5P6,Q9NZJ7,O14773,Q9NR77,Q8TD30,Q9Y6X9,P00846,Q99720,P42858,Q13510 17 +Barrel shaped chest 0.794288857998289 1.52904085231865 0.1262543167637111 1.0 0.8888423083690973 4 Q14739,Q96AX1 2 +Macrodontia of permanent maxillary central incisor 0.9529645578005964 1.5287612857674735 0.1263236330426871 1.0 0.8888423083690973 2 P21281 1 +Chordee 0.7166156150203693 1.527361137674662 0.1266712344748768 1.0 0.8888423083690973 5 P53701,P16435 2 +Laryngomalacia 0.5620446157458086 1.5259750733419075 0.1270160724248605 1.0 0.8898929436709508 15 P07602,Q09472,Q92766,P27635,Q9NZJ7,O14802,P16435 7 +Abnormal heart sound 0.715880638361726 1.5242523674557933 0.1274456809573561 1.0 0.8905647578276019 5 P10253 1 +Bowing of the legs 0.4507947913250373 1.5240249662472878 0.1275024746462232 1.0 0.8905647578276019 47 Q13126,P16278,P16435,Q9NR77,P08236,Q13509,Q7LGA3 7 +Hyperventilation 0.6867311951826036 1.5224230439269169 0.1279031144348872 1.0 0.8919971023509491 6 P00846 1 +Abnormality of the extraocular muscles 0.9703186513258686 1.5174382238828592 0.1291560794331703 1.0 0.896622341392222 3 Q9BVA1 1 +Abnormal retinal vascular morphology 0.4364832966311937 1.5120423687650917 0.1305230844436966 1.0 0.9013504783526618 51 P07602,Q96DF8,P16278,P03886,O43826,P10619,P00846 7 +Soft skin 0.652553366497505 1.5108555370375027 0.1308252612737255 1.0 0.9013504783526618 8 Q13126 1 +Cold induced muscle cramps 0.9682565933129718 1.5099920750234492 0.1310454463737156 1.0 0.9015057027307948 3 Q9NR77 1 +Mitral stenosis 0.7888703369343905 1.507618782162546 0.1316521228729859 1.0 0.90431525967423 4 O75844 1 +Abnormality of lysosomal metabolism 0.7876375627503328 1.502742475829142 0.1329054648592724 1.0 0.9056287512484448 4 Q9NZJ7,P07602 2 +Limb tremor 0.7100408581010444 1.4995338985158588 0.1337351814369665 1.0 0.9076877418660776 5 P04350 1 +Abnormality of the umbilical cord 0.680858711138226 1.496699704791641 0.1344714131253697 1.0 0.9079189565513964 6 O75844 1 +Thoracic kyphosis 0.5499537987224651 1.4956518530391376 0.1347444031134057 1.0 0.9079189565513964 16 O00443,P08236,P04062 3 +Hypocholesterolemia 0.6759894109089647 1.4941724125830569 0.1351305612024025 1.0 0.9079189565513964 7 Q15800,P07602 2 +Calcinosis 0.7086315222716152 1.4935639565410137 0.1352896260968108 1.0 0.9079189565513964 5 O75844 1 +Brittle hair 0.5561795613734836 1.4930642331798594 0.1354203738390222 1.0 0.9079189565513964 15 Q15436,Q6PGP7,Q9Y487,P62266,O75844 5 +Abnormality of the vasculature of the eye 0.4076198742159162 1.4917684349622384 0.1357598615145916 1.0 0.9079189565513964 74 P02786,P50851,Q13315,P10619,Q96AX1,Q14739,P00846,P38435,P28070,P16278,P49454,P04066,P03886,O43826,Q12948,P06280,Q96DF8,P17900,Q13510,Q9NZ08,P07602,Q92766,Q9NZJ7,P12004,P19447,P29401 26 +Hypoplastic nipples 0.5814740866758679 1.4869223022811118 0.1370353331589857 1.0 0.909357289960682 12 P07437,Q9Y223 2 +Gastrointestinal inflammation 0.517018595932979 1.4867590197300344 0.1370784685248964 1.0 0.909357289960682 20 P08183,P49748 2 +Orthostatic hypotension due to autonomic dysfunction 0.6204147329534503 1.4863377356336298 0.1371898101341455 1.0 0.909357289960682 9 Q9NZJ7,P07602,P04062 3 +Spastic diplegia 0.4774937369139286 1.4829716193395508 0.1380819513055591 1.0 0.909357289960682 27 Q9NZJ7,Q13509,P07602,Q99720 4 +Enlarged thorax 0.5405463131522653 1.4824851514791904 0.1382112516258886 1.0 0.909357289960682 17 Q14739,P08236,O75844,Q96AX1 4 +Abnormal metabolic brain imaging by mrs 0.5399915231964686 1.479225476535423 0.1390800627072399 1.0 0.909357289960682 17 P00403,P07602,P03886 3 +Lissencephaly 0.4252251328665044 1.474379776202124 0.1403793665125752 1.0 0.909357289960682 53 Q96T60,Q9BVA1,Q9Y5P6,Q15042,Q86XL3,Q9NPF4,P23786,Q15392,Q9Y487,Q6ZXV5,Q13509 11 +Ectrodactyly 0.538631158347225 1.4712296380297862 0.141229024476577 1.0 0.909357289960682 17 Q9NR77,Q99720,Q9Y6X9 3 +Abnormal brain lactate level by mrs 0.5865301300750461 1.4703689797255932 0.1414618480441882 1.0 0.909357289960682 11 P03886 1 +Nasogastric tube feeding in infancy 0.5942515483849262 1.4692468777989145 0.1417658396109793 1.0 0.909357289960682 10 P07602,Q09472,Q9NZJ7,P49711,Q8TD30 5 +Abnormal full field electroretinogram 0.6703160222251126 1.4690596206342164 0.1418166187640945 1.0 0.909357289960682 7 P00846 1 +Abnormal light and dark adapted electroretinogram 0.6703160222251126 1.4690596206342164 0.1418166187640945 1.0 0.909357289960682 7 P00846 1 +Coxa vara 0.5695281180959884 1.4685960611792177 0.1419423838407139 1.0 0.909357289960682 13 Q96AY3,P50542,Q9NUQ7,Q9Y487 4 +Cerebellar vermis atrophy 0.5778609579788219 1.467930666820258 0.1421230570456004 1.0 0.909357289960682 12 P07437,P42858 2 +Limb joint contracture 0.4336585675777007 1.465486946342996 0.1427881112281817 1.0 0.909357289960682 101 O00443,Q9Y5P6,Q86XL3,Q15042,P49711,Q99720,Q8IZA0,P27635,Q8N2K0,P16435,Q9NR77,P63241,O75844,Q8IWS0,P48651,Q08J23,Q9Y4R8,P23786,Q9Y6X9,Q13509,Q6DKJ4,Q9H4L7,Q96AY3,P42892,O14802,Q9NPF4,P50542,Q15392,Q9Y619,Q7LGA3 30 +Myositis 0.6426984517984583 1.4653997322668677 0.1428118904531441 1.0 0.909357289960682 8 Q9NZ08,Q9Y3Z3 2 +Dysesthesia 0.6733984186730959 1.4639694292489158 0.14320230139674 1.0 0.909357289960682 6 Q9NR77 1 +Abnormality of metacarpophalangeal joint 0.7772389178171253 1.4615759323491555 0.1438574536622947 1.0 0.911297008546842 4 P16435 1 +Abnormality of the spleen 0.4435938940880923 1.4565456100207737 0.1452418507564641 1.0 0.9116904273635236 112 O00443,Q7L590,Q14108,P08236,P10619,Q96AX1,Q14739,Q9Y3Z3,P28070,P16278,O15118,P54802,Q9NZ08,P10253,P07602,P04062,Q9NZJ7,P21281,Q15392,P15586,Q9Y223 21 +Ulnar deviation of the wrist 0.7757275210934333 1.4555878887694311 0.1455065780637539 1.0 0.9116904273635236 4 P16278 1 +Wide anterior fontanel 0.5030420999393217 1.454677725386876 0.145758501966196 1.0 0.9116904273635236 21 Q15436,Q09472,P42345,Q08J23,P16435,P50542,Q9Y487,O75718 8 +Gingival bleeding 0.5906722344485807 1.4511899111785354 0.1467269854099706 1.0 0.9116904273635236 10 Q14108,P04062 2 +Focal dystonia 0.5110796107686081 1.449186367154338 0.1472855436630666 1.0 0.9116904273635236 20 P04350,Q99720 2 +Pulmonary embolism 0.7736906859995596 1.4475164024224765 0.1477523459009719 1.0 0.9116904273635236 4 Q9NZ08 1 +Prenatal maternal abnormality 0.5480038793918627 1.4470629761121494 0.1478792863028477 1.0 0.9116904273635236 15 P49366,P16435,Q8TAA9,Q14739,O43772 5 +Abnormal thoracic spine morphology 0.4718417218375854 1.4437680767547545 0.1488042245916414 1.0 0.9116904273635236 28 O00443,P04062,P08236,Q96AX1,Q13509,O75844 6 +Abnormal sella turcica morphology 0.664440440601929 1.4430163154969622 0.1490158752238799 1.0 0.9116904273635236 7 P16278,P08236 2 +Focal t2 hyperintense basal ganglia lesion 0.5183406121633002 1.4420962909128154 0.149275211279604 1.0 0.9116904273635236 19 P00846,Q96CU9 2 +Skeletal dysplasia 0.4660424152548812 1.4410751594085 0.149563450453988 1.0 0.9116904273635236 35 O00443,P27635,P16278,Q6UX04,P50542,Q9NUQ7,P10619,Q96AX1,Q14739 9 +Adrenal hyperplasia 0.6961136406483122 1.440467461662428 0.1497351893555802 1.0 0.9116904273635236 5 P21281 1 +Abnormality of the calf 0.4139604319528467 1.4396161189936985 0.1499760366776421 1.0 0.9116904273635236 55 Q13126,P16278,P16435,Q9NR77,P08236,Q13509,Q7LGA3 7 +External ear malformation 0.5551164675360768 1.4372703353910536 0.1506411944189665 1.0 0.9116904273635236 14 Q8NCH0,P07437 2 +Horizontal nystagmus 0.4806917776455829 1.4331801124482382 0.1518063715768354 1.0 0.9116904273635236 23 P07602,P04062,Q9NZJ7,O14773,P00846 5 +Shuffling gait 0.5787816094592854 1.430434391216669 0.1525923835593023 1.0 0.9116904273635236 11 O75844 1 +Wide intermamillary distance 0.4801230216806675 1.429262023642209 0.1529289367846851 1.0 0.9116904273635236 23 P07437,Q9Y5P4 2 +Hypoplasia of the brainstem 0.4689370849882222 1.428734451595683 0.1530805717540126 1.0 0.9116904273635236 30 Q9Y5P6,Q7Z460,P07437,Q6ZXV5,Q13509,Q13885 6 +Submucous cleft of soft and hard palate 0.4896551838717795 1.427858296804564 0.1533326491561935 1.0 0.9116904273635236 22 P48651,Q08J23,Q96DF8,Q15392,P62266,O75844,Q7LGA3 7 +Abnormality of the nasolabial region 0.6930055861317344 1.4272661684242696 0.1535031883538371 1.0 0.9116904273635236 5 Q8NCH0 1 +Prominent nasolabial fold 0.6930055861317344 1.4272661684242696 0.1535031883538371 1.0 0.9116904273635236 5 Q8NCH0 1 +Broad hallux phalanx 0.9271281881417696 1.4261841827006787 0.1538151841142923 1.0 0.9116904273635236 2 P49711 1 +Cardiovascular calcification 0.6340653361952691 1.4254840633711805 0.1540173236008222 1.0 0.9116904273635236 8 O75844,P04062 2 +Aplasia hypoplasia involving the vertebral column 0.5529166558672003 1.4251466213247324 0.1541148224447734 1.0 0.9116904273635236 14 Q14739,P16278,P08236,Q8TAA9 4 +Peripheral axonal neuropathy 0.4124241817408277 1.4246034759669848 0.1542718546928203 1.0 0.9116904273635236 55 Q9BPX6,P07602,Q8IV08,P03886,P00403,Q9Y6X9,P00846,Q13509 8 +Tachycardia 0.469223175733459 1.4243776634144094 0.1543371765826602 1.0 0.9116904273635236 24 P23786,O43772,P42892,P49748 4 +Abnormal cardiac ventricular function 0.5142463968266041 1.4167826517804474 0.156546483313777 1.0 0.9116904273635236 19 P10253,Q15233,P03886,P00403,P49748,O75844 6 +Inability to walk 0.4058859546607473 1.4148198732109956 0.1571213157522375 1.0 0.9116904273635236 79 O14949,Q8TEQ6,Q96N66,P27635,Q9Y5P6,Q7Z460,Q9NR77,O75503,Q96AX1,Q9Y6X9,P00846,Q13509,Q99720,P42858,Q13510,Q96CU9 16 +Unexplained fevers 0.6899442023893958 1.4142568721668665 0.1572864949182468 1.0 0.9116904273635236 5 Q9Y3Z3,P07602 2 +Vascular tortuosity 0.9413518886679988 1.4127937459257809 0.1577163776794767 1.0 0.9116904273635236 3 P00846,P03886 2 +Abnormal 2nd finger morphology 0.66165681282837 1.4123503845842509 0.1578468177436209 1.0 0.9116904273635236 6 Q9H6K4 1 +Abnormal elasticity of skin 0.398762582274961 1.4109324770338378 0.158264524845509 1.0 0.9116904273635236 58 Q13126,Q9H4L7,P48651,Q12948,P04062,P28340,P21281,Q15334,P07437,Q9Y487,Q9UHX1,Q8NCH0,O00170,O75844,P38435 15 +Hyperesthesia 0.9231533620404108 1.410414559759432 0.158417308713969 1.0 0.9116904273635236 2 P07602 1 +Bilateral tonic clonic seizure with focal onset 0.9231533620404108 1.410414559759432 0.158417308713969 1.0 0.9116904273635236 2 P07602 1 +Cognitive impairment 0.4767700832561416 1.4098101535151497 0.1585957477119757 1.0 0.9116904273635236 155 Q9Y2R0,Q9BVA1,Q9Y5P6,Q14108,O75503,Q9Y487,P00846,Q99720,P42858,Q8NC96,Q09472,P04350,P16278,O15118,P03886,P00403,O43826,P05067,O43681,P50897,P35270,P54802,Q9H6K4,Q13510,Q9NZ08,Q96T60,P07602,Q05639,P04062,Q9NZJ7,Q9NPF4,Q9NPL8,O95470,P50542,Q96RR1,Q9Y223 36 +Multifocal epileptiform discharges 0.4673773117786131 1.4092473341144682 0.1587620457880159 1.0 0.9116904273635236 26 Q96T60,Q08J23,Q2M389,Q9UBX3,Q96N66,Q9NZ01,O75503,Q9NUQ7 8 +Nephrotic syndrome 0.4868630099564563 1.4091558799138002 0.1587890805189671 1.0 0.9116904273635236 22 Q9NPF4,Q14108,O95470,Q96AX1,Q8NCH0 5 +Bifid tongue 0.7638590785240874 1.408531710727319 0.1589736839129187 1.0 0.9116904273635236 4 Q8NCM8,Q6DKJ4 2 +Abnormal femoral head morphology 0.5127401466949955 1.4074603237744832 0.1592909343891579 1.0 0.9116904273635236 19 O00443,P16278,P50542,Q9NUQ7,Q7LGA3 5 +Abnormal femoral neck morphology 0.4599514435725989 1.403795034624359 0.1603798929976674 1.0 0.9116904273635236 36 O00443,Q96AY3,P16278,P04066,P50542,Q9NUQ7,Q9Y487,O75844 8 +Microdontia 0.4661841365434591 1.4010396800460858 0.1612022076807673 1.0 0.9116904273635236 27 O00443,Q15436,P49711,P21281,Q9Y487,Q7LGA3,Q12948 7 +Congenital sensorineural hearing impairment 0.6868217381446442 1.40098205434043 0.1612194395696036 1.0 0.9116904273635236 5 Q16740,Q8WWQ0 2 +Elevated circulating long chain fatty acid concentration 0.920172242464394 1.3985908390117363 0.1619357150550635 1.0 0.9116904273635236 2 P23786 1 +Irregular capital femoral epiphysis 0.9201722424643926 1.3985908390117314 0.1619357150550651 1.0 0.9116904273635236 2 Q9NUQ7 1 +Macroglossia 0.4623722712944346 1.3961847464341557 0.1626588688585608 1.0 0.9116904273635236 33 O00443,P10253,Q9Y5P6,P16278,P04066,P21281,Q96AX1,Q7LGA3 8 +Diffuse cerebral atrophy 0.5307934959817039 1.3852926744090135 0.1659629928154005 1.0 0.9186373910570894 16 Q96T60,P07602,P16278 3 +Asymmetric septal hypertrophy 0.916528651871481 1.3841442943277402 0.1663142763402922 1.0 0.919465956834028 2 P54802 1 +Velopharyngeal insufficiency 0.7568876521506285 1.380868199553836 0.1673194892693903 1.0 0.9198974020901322 4 Q9BUF5 1 +Osteopenia 0.3891670702957458 1.3785012447423934 0.1680485838109737 1.0 0.9201315615388372 67 Q13126,P07602,P04062,Q96AY3,Q9NZJ7,P49711,Q14108,O43826,Q9Y487,O75718,O00170,O75844 12 +Abnormal motor nerve conduction velocity 0.5077370398868928 1.3764606595691309 0.1686790590052118 1.0 0.920168263090872 19 Q9NR77,Q99720,Q9Y6X9 3 +Limb girdle muscle weakness 0.4626031043714279 1.375575986125765 0.1689529455773695 1.0 0.920168263090872 25 Q13126,P07602,Q9Y5P6,Q9NZJ7,Q9Y6X9,Q9Y223 6 +Synostosis involving bones of the hand 0.5973403789126167 1.374872542087724 0.1691709632448319 1.0 0.920168263090872 9 Q15233,Q6DKJ4,P16435 3 +Paresthesia 0.4905557665574341 1.3733007271160425 0.1696588766602322 1.0 0.920168263090872 21 Q9NR77,Q9NZ08,P05067,Q9H6K4 4 +Bilateral sensorineural hearing impairment 0.4620086258212582 1.3730637084976451 0.1697325420179729 1.0 0.920168263090872 24 P07602,Q9NZJ7,P03886,P00403,O43681,Q13509 6 +Menorrhagia 0.753768983992463 1.368488822947728 0.171159118222099 1.0 0.920168263090872 4 O43826 1 +Dyslexia 0.6787383499628564 1.3665915491167924 0.1717533675686642 1.0 0.920168263090872 5 Q96T60,Q9H6K4 2 +Cerebral calcification 0.4584812426914886 1.3665277185809843 0.171773386887009 1.0 0.920168263090872 33 Q9Y3Z3,P03886,P00403,P23786,Q96AX1 5 +Mitral valve calcification 0.7529888356625244 1.3653917437699183 0.1721299574403976 1.0 0.920168263090872 4 O75844 1 +Cardiac valve calcification 0.7529888356625244 1.3653917437699183 0.1721299574403976 1.0 0.920168263090872 4 O75844 1 +Vertebral hypoplasia 0.5728728287016974 1.361129388947887 0.1734728036440871 1.0 0.920168263090872 10 Q6NUQ1,P16278,O14802,Q8TAA9,Q14739 5 +Resting tremor 0.5049011844822211 1.3588667306916653 0.1741888229197112 1.0 0.920168263090872 19 Q9BPX6,P07602,P04062,Q9NZJ7,Q9H6K4,Q96RR1 6 +Muscle fiber atrophy 0.5193168611443757 1.357281095434809 0.1746919117513306 1.0 0.920168263090872 17 Q99720 1 +Congestive heart failure 0.3930965608680382 1.3528137966276013 0.1761151240294036 1.0 0.920168263090872 58 P10253,P16278,P03886,P00403,P07437,Q96AX1,Q70HW3 7 +Short lingual frenulum 0.7495975749058914 1.351927637544119 0.1763984652458587 1.0 0.920168263090872 4 O75844 1 +Dysdiadochokinesis 0.5247994686959103 1.3506225936344043 0.1768163595139775 1.0 0.920168263090872 16 P04350 1 +Progressive neurologic deterioration 0.4952432126269336 1.3485864109465615 0.177469847883311 1.0 0.920168263090872 20 P07602,P04062,Q9NZJ7,P16278,P54802,O43681 6 +Slow pupillary light response 0.9234592445328126 1.348165668654921 0.1776051040069868 1.0 0.920168263090872 3 Q9NR77,P07602 2 +Abnormal pupillary light reflex 0.9234592445328126 1.348165668654921 0.1776051040069868 1.0 0.920168263090872 3 Q9NR77,P07602 2 +Erlenmeyer flask deformity of the femurs 0.923459244532803 1.3481656686548864 0.1776051040069979 1.0 0.920168263090872 3 P07602,P04062 2 +Abnormal femoral neck head morphology 0.4333068033679019 1.3471221609346609 0.1779408919197871 1.0 0.920168263090872 46 O00443,Q09472,Q96AY3,P16278,P04066,P50542,Q9NUQ7,Q9Y487,Q14739,O75844,Q7LGA3 11 +Open mouth 0.4573175658945493 1.346362621562243 0.1781855993399093 1.0 0.9203901682778328 31 Q15233,P04062,Q96DF8,P04350,Q86XL3,P21281,Q13045,P62266 8 +Optic disc pallor 0.4444951215179769 1.3456653658773068 0.1784104606939474 1.0 0.9205091755939978 41 Q9Y6M9,P03886,Q9H6K4,P00846,Q96CU9 5 +Abnormal circulating acetylcarnitine concentration 0.6166298642702379 1.344639803035684 0.1787415829959995 1.0 0.921175548073168 8 P23786 1 +Elevated creatine kinase after exercise 0.746135425202174 1.3381803587873744 0.1808376501790407 1.0 0.9298765754978634 4 O43772 1 +Periorbital fullness 0.5088945730324295 1.337153353921968 0.1811725844545817 1.0 0.9305497271366524 18 P07437,Q7LGA3,Q9Y223,Q96AX1 4 +Abnormal urine carbohydrate level 0.5602638148367936 1.334649161733391 0.1819911997501693 1.0 0.9318756664190736 11 P10253,P16278 2 +Abnormal branching pattern of the aortic arch 0.903610467042068 1.3329763561261143 0.1825395630374982 1.0 0.9318756664190736 2 Q96DF8 1 +Centrally nucleated skeletal muscle fibers 0.643614141209129 1.3328264851549714 0.1825887520502767 1.0 0.9318756664190736 6 Q9BPX6 1 +Abnormal leukocyte physiology 0.3825001885669985 1.3322108664882346 0.1827909067760225 1.0 0.9318756664190736 60 Q96J02,Q9UJW0,Q6PGP7,P28070,P42345,P02786,Q96DF8,P50851,Q92766,P04062,P09601,Q14108,Q13315,P19447,Q96AX1,P17812 16 +Palpebral edema 0.6705202060935929 1.3315975839342462 0.1829924592961087 1.0 0.9318756664190736 5 P50542 1 +Hypocalcemia 0.5213693301242224 1.3307552342349205 0.1832695621087281 1.0 0.9318756664190736 16 O00443,P49748 2 +Progressive psychomotor deterioration 0.6129135705790726 1.3273749883461592 0.1843846691843087 1.0 0.9354599289762316 8 Q9NZJ7,P07602,P16278 3 +Stroke like episode 0.6687390457182827 1.3240100181082757 0.1854997175894017 1.0 0.9390279821590028 5 P03886 1 +Delayed eruption of permanent teeth 0.6405747437358252 1.3194114828505852 0.1870315849403838 1.0 0.9429807491935044 6 P21281 1 +Stuttering 0.9149332044379184 1.317393874705788 0.1877066330507397 1.0 0.9429807491935044 3 P03886 1 +Muscle abnormality related to mitochondrial dysfunction 0.4499359151333968 1.3161291935733868 0.1881306839644403 1.0 0.9429807491935044 35 Q9UBX3,Q9Y6M9,Q86Y39,P03886,P00846,Q96CU9 6 +Colitis 0.5566519372055848 1.3159179057199035 0.188201598192792 1.0 0.9429807491935044 11 P50851,O43826,P49748 3 +Abnormal circulating carbohydrate concentration 0.4456334405372049 1.3130295970779946 0.1891729751841442 1.0 0.9429807491935044 38 Q9BWD1,Q9Y6M9,Q86Y39,P03886,Q70HW3,Q96CU9 6 +Abnormality of the pulmonary veins 0.6388883164259668 1.311966289371653 0.1895315090288858 1.0 0.9429807491935044 6 O75718,Q15392 2 +Abnormality of the columella 0.4888658555874739 1.3079279660334984 0.1908977429416292 1.0 0.9429807491935044 20 Q96J02,O00443,Q09472,P49454,Q6UX04,P49711 6 +Dilation of virchow robin spaces 0.8969857568731369 1.306775347635115 0.1912890200439951 1.0 0.9429807491935044 2 P27635 1 +Generalized onset motor seizure 0.417290673841182 1.305534989988559 0.1917107406702725 1.0 0.9429807491935044 50 Q96T60,P37287,P07602,Q05639,P04062,P27635,Q96N66,Q9NZJ7,P16278,P03886,P43034,P00846,Q13510 13 +Frequent falls 0.4446368081652313 1.3050530818892945 0.1918747733745849 1.0 0.9429807491935044 38 Q13510,P07602,P04062,P27635,Q9Y5P6,Q9NZJ7,Q9NR77,O43681,P00846 9 +Basal ganglia cysts 0.6330783576467364 1.3035119513717062 0.1924000388506948 1.0 0.9429807491935044 7 P00846 1 +Skeletal muscle hypertrophy 0.4391236411821254 1.3013784949309068 0.1931289309327102 1.0 0.9429807491935044 41 O00443,P10253,Q9Y5P6,P16278,P04066,P21281,Q9NR77,Q96AX1,Q7LGA3 9 +Ectopic calcification 0.406833188472983 1.2993880881589146 0.1938107775381401 1.0 0.9429807491935044 53 Q9Y3Z3,P04062,P03886,P00403,P23786,P05067,P50542,P08236,Q96AX1,O75844 10 +Anteriorly placed anus 0.5604751111938552 1.2981819337705236 0.1942248246742317 1.0 0.9429807491935044 10 P48651,P49748,P53701,P16435 4 +Venous insufficiency 0.6318623326518844 1.2980901766984905 0.1942563494762597 1.0 0.9429807491935044 7 Q92766,P04062 2 +Varicose veins 0.6318623326518844 1.2980901766984905 0.1942563494762597 1.0 0.9429807491935044 7 Q92766,P04062 2 +Metaphyseal dysplasia 0.5603246034615419 1.297416873164962 0.19448778997096 1.0 0.9429807491935044 10 O00443,Q6UX04 2 +Generalized muscle weakness 0.4512084775101693 1.2967954284043612 0.194701584092134 1.0 0.9429807491935044 30 P10253,Q15165,P42858 3 +Raynaud phenomenon 0.6352227375332573 1.2957796675334567 0.1950514049575089 1.0 0.9429807491935044 6 Q9Y3Z3,O75844 2 +Abnormality of the distal phalanges of the toes 0.7353248210827712 1.2952496161691818 0.1952341338289227 1.0 0.9429807491935044 4 O75844 1 +Dilated cardiomyopathy 0.4460953054582797 1.29517098834144 0.1952612505204904 1.0 0.9429807491935044 36 P16278,P03886,P23786,P49748,P00846 5 +Hypoplasia of the iris 0.6349481083100085 1.2945667508406546 0.1954697284739404 1.0 0.9429807491935044 6 Q12948,Q7LGA3 2 +Foot dorsiflexor weakness 0.4507884012594887 1.2936597496657825 0.1957829741730221 1.0 0.9429807491935044 30 Q9NR77,Q9Y6X9,Q14739,Q99720,Q9Y223 5 +Abnormal ureter morphology 0.4510445471630729 1.292543109708564 0.1961691267025003 1.0 0.9429807491935044 25 Q96T60,P23786,O75844,Q7LGA3 4 +Hyperintensity of cerebral white matter on mri 0.4941513063339667 1.292039947322433 0.196343310824183 1.0 0.9429807491935044 19 P07602,P10253,P27635,Q9NZJ7,O75503 5 +Respiratory failure 0.3742211243113937 1.2912698544058028 0.1966101199854204 1.0 0.9429807491935044 61 P07602,P10253,Q15165,P53701,Q9Y5P6,Q9NZJ7,Q16637,P23786,Q70HW3,Q13510 10 +Female hypogonadism 0.6610138294717054 1.2910921154595272 0.1966717377589435 1.0 0.9429807491935044 5 Q13315,O00170,O75844 3 +Hypointensity of cerebral white matter on mri 0.6334322870212833 1.2878715873585258 0.1977906674146805 1.0 0.9429807491935044 6 Q9Y3Z3,P07602 2 +Subcutaneous hemorrhage 0.4373961672869917 1.2871197853764051 0.1980525402590878 1.0 0.9429807491935044 41 Q13126,P04062,Q14108,O43826,Q8NCH0,P49257,O00170,P38435 8 +Abnormal mitochondria in muscle tissue 0.4855368030597394 1.286675656810824 0.1982073612981394 1.0 0.9429807491935044 20 P03886,Q9Y6M9,Q86Y39,Q96CU9 4 +Thin skin 0.4497500142770755 1.2855724666395507 0.1985923109481731 1.0 0.9429807491935044 24 Q13126,Q9H4L7,P48651,O14802,P46821,O15111,Q6ZXV5,Q9Y619,O00170,O75844 10 +Abnormality of endocrine pancreas physiology 0.7324801636527863 1.2839534814099796 0.199158232574458 1.0 0.9429807491935044 4 P53985,Q14739 2 +Omphalocele 0.5421782586778865 1.2793071001133527 0.2007889333158452 1.0 0.9429807491935044 12 Q8NCM8,O15111,P43034,Q14739,Q6DKJ4 5 +Epiphyseal stippling 0.5566930243595979 1.278951369867686 0.2009141812890127 1.0 0.9429807491935044 10 Q9UBM7,P50542,P08236,Q14739,P38435 5 +Hammertoe 0.4843072796084151 1.2788220672895187 0.2009597211611677 1.0 0.9429807491935044 20 Q9NR77,Q99720,Q9Y6X9 3 +Adducted thumb 0.4756975605249083 1.276024772391214 0.2019467622592903 1.0 0.9452692353763664 21 Q8NCH0,P42892,Q86XL3,Q9NPF4 4 +Retinal dysplasia 0.6306462792391407 1.2755644035288058 0.2021095440799327 1.0 0.9452692353763664 6 P07437 1 +Pancytopenia 0.4452503069740672 1.2719491321319047 0.2033911933779038 1.0 0.9457040236322316 34 Q14108,P00374 2 +Slurred speech 0.6007588368878682 1.270846616355906 0.2037832210062475 1.0 0.9457040236322316 8 P16278 1 +Vertebral compression fracture 0.5106819819377001 1.268743532549295 0.2045325506665092 1.0 0.9457040236322316 16 Q96AY3,O75718,P04062,Q14108 4 +Aplasia hypoplasia of the cerebral white matter 0.6247407443415872 1.266325920707343 0.2053964205358078 1.0 0.9457040236322316 7 P03886 1 +Widened cerebral subarachnoid space 0.8992775319882442 1.2609618145083794 0.2073226052501704 1.0 0.9457040236322316 3 P03886 1 +Juvenile aseptic necrosis 0.6271250109398772 1.2600064761650196 0.2076670260252968 1.0 0.9457040236322316 6 Q9NUQ7,Q09472,Q8IWS0 3 +Proximal tubulopathy 0.4646582083903918 1.2597940149775373 0.2077436794020557 1.0 0.9457040236322316 22 P03886,Q9Y6M9,Q86Y39,Q96CU9 4 +Abnormality of the tongue 0.3931261478987776 1.2554942824199502 0.2092993823777895 1.0 0.9457040236322316 81 O00443,Q9Y5P6,Q15042,Q16637,Q96AX1,P04350,P16278,P04066,Q9BQT8,O75844,P48651,Q9Y4R8,O15111,Q9Y6X9,O00170,Q13510,Q6DKJ4,P10253,P21281,P50542,Q9NQT5,Q7LGA3 22 +Narrow mouth 0.3853560590073711 1.253643177466333 0.2099717299263763 1.0 0.9457040236322316 74 P37287,Q15042,P49711,Q9Y487,P42858,Q09472,P27635,P16435,P07437,P43034,O75844,Q15233,Q86UE8,P04062,P28340,Q9NPF4,Q15392,Q8NCH0,Q7LGA3 19 +Appendicular hypotonia 0.8834051010268332 1.2531708552455718 0.2101435341342503 1.0 0.9457040236322316 2 P04062 1 +Incomplete penetrance 0.4458216934517968 1.2529648656195476 0.2102184934061992 1.0 0.9457040236322316 28 P00846 1 +Vegetative state 0.8969516235917868 1.2525881535975556 0.2103556283164125 1.0 0.9457040236322316 3 Q9NZJ7,P07602 2 +Progressive peripheral neuropathy 0.8969516235917868 1.2525881535975556 0.2103556283164125 1.0 0.9457040236322316 3 Q9NZJ7,P07602 2 +Confusion 0.501666658157997 1.2525765884675328 0.2103598394079542 1.0 0.9457040236322316 17 Q9NZ08,P08397,O14802,P26358,P05067,P19447,Q9Y619,O96008,P18074 9 +Vertebral wedging 0.883073865518385 1.2518655115984882 0.2106188736905556 1.0 0.9457040236322316 2 Q96AY3 1 +Patchy changes of bone mineral density 0.8964726586708445 1.2508641834779848 0.2109840331737769 1.0 0.9457040236322316 3 Q13126 1 +Deviated nasal septum 0.8827426300099377 1.2505602766182815 0.2110949509730892 1.0 0.9457040236322316 2 Q09472 1 +Abnormal oral frenulum morphology 0.529010565780799 1.2495040010188458 0.2114807910264271 1.0 0.9457040236322316 13 Q9Y4R8,Q6DKJ4,O75844,P21281 4 +Distal peripheral sensory neuropathy 0.6504556641146619 1.246090267903959 0.2127312573255062 1.0 0.9475266256461268 5 P03886 1 +Macrocytic anemia 0.4418202099422091 1.2454459786468537 0.2129678612008407 1.0 0.9476550389629608 34 P00374 1 +Abnormal metatarsal morphology 0.4699941943713058 1.2385853698599134 0.2154990888609314 1.0 0.956689563864722 21 P16435,P50542,P08236,Q15392,Q13509 5 +Arrhinencephaly 0.5341325630512057 1.23657574286565 0.2162446300097169 1.0 0.956689563864722 12 Q9Y3Z3,Q92766,P21281,Q8TAA9,Q92890 5 +Abnormal circulating long chain fatty acid concentration 0.8912864416447739 1.2322060282127307 0.2178721320439889 1.0 0.9595981686292993 3 P23786 1 +Oligohydramnios 0.4429579144773908 1.2318749771569393 0.217995790003127 1.0 0.9595981686292993 28 P49366,Q9NPF4,P16435,P23786,Q9Y5P4,Q7LGA3 6 +Thoracolumbar kyphosis 0.6202742149307184 1.2297323170206964 0.2187973608230577 1.0 0.9614015055047848 6 P04062 1 +Ankylosis 0.6454776931995222 1.2248736134103624 0.2206228436533868 1.0 0.9666609270975168 5 O75844,P16435 2 +Ureteral duplication 0.5905378505207939 1.2232606883188266 0.221231250091912 1.0 0.967435984342484 8 P23786,O75844 2 +Brisk reflexes 0.4408922930971595 1.2221660427171814 0.2216448423577333 1.0 0.9680241062554904 24 Q5JRX3,O15382,Q99720 3 +Muscle hypertrophy of the lower extremities 0.6146334708219456 1.221220725964021 0.2220024589220002 1.0 0.9680241062554904 7 Q9NR77 1 +Thoracolumbar scoliosis 0.6176444288702805 1.2181103663602473 0.2231820350606113 1.0 0.968114419560734 6 P21281,P27635 2 +Abnormal social behavior 0.3705849472426322 1.21480427346291 0.2244407505635837 1.0 0.968114419560734 64 P07602,Q15233,Q09472,Q96CW1,Q9NZJ7,Q9Y6M9,Q86Y39,Q9NPL8,P03886,Q8TB37,P05067,Q96RR1,O43681,Q13509,Q2TAA5,Q96CU9 16 +Metaphyseal widening 0.4947851443837356 1.2116476770477702 0.2256472758605245 1.0 0.968114419560734 17 Q14739,P16278,P48651,Q96AX1 4 +Tremor by anatomical site 0.4398161622568231 1.2116246876356933 0.225656079905689 1.0 0.968114419560734 25 P04350,Q99720 2 +Abducens palsy 0.8850231941683293 1.2096969342176005 0.2263952067073669 1.0 0.968114419560734 3 Q9NZJ7,P07602 2 +Fetal ultrasound soft marker 0.529041271386636 1.2095127573219746 0.226465912916421 1.0 0.968114419560734 12 P21281,P16435 2 +Premature rupture of membranes 0.641471546889627 1.2078018125298304 0.2271235041378927 1.0 0.968114419560734 5 O75844 1 +Generalized hyperkeratosis 0.6413149267896152 1.207134464194785 0.2273803641288849 1.0 0.968114419560734 5 O75844 1 +Malrotation of small bowel 0.7129614197307168 1.20648923386087 0.2276289078066358 1.0 0.968114419560734 4 Q8NCH0 1 +Sensory neuropathy 0.4392593739590324 1.2046196737855603 0.2283501582057172 1.0 0.968114419560734 28 P00403,P00846,Q8IV08,P03886 4 +Blindness 0.3807657687510968 1.204290357245859 0.2284773723856512 1.0 0.968114419560734 74 Q9NZ08,P07602,P50897,P53701,Q9Y5P6,P16278,Q9Y6M9,Q9NZJ7,Q86Y39,P03886,Q9H6K4,P00846,O00170,Q96CU9 14 +Generalized myoclonic seizure 0.4305954574375203 1.203964738840261 0.2286032076007258 1.0 0.968114419560734 39 P37287,P07602,Q05639,P04062,Q96N66,Q9NZJ7,P16278,P03886,P43034,P00846,Q13510 11 +Prolonged partial thromboplastin time 0.6139511637753121 1.2017890051527662 0.2294452863742644 1.0 0.9689814362527964 6 P49257,Q9Y223 2 +Lower limb amyotrophy 0.4989933890171927 1.2007699233757771 0.2298404617964431 1.0 0.969450576209093 16 Q9NR77,Q9Y223 2 +Prolonged neonatal jaundice 0.4921596197735168 1.1960207449539206 0.2316884637087795 1.0 0.971532924172114 17 O15118,P49711 2 +Secondary microcephaly 0.3755357152530865 1.1955005230761184 0.2318915319962435 1.0 0.971532924172114 70 P00374,P37287,Q9Y263,O95630,Q09472,P50897,Q96T60,Q05639,Q9NQT5,Q86Y39,Q9BT22,Q9Y5P4,Q8TD30,Q9Y487,Q9UHX1,P43034,P49770,Q96CU9 18 +Genu valgum 0.4371275078089845 1.1943347329183134 0.2323470562609968 1.0 0.9720541013401226 31 Q9NR77,P16278,Q13509,Q7LGA3 4 +Abnormality of lower limb epiphysis morphology 0.4976119205327453 1.1927283930287662 0.2329757620520687 1.0 0.9724039045715794 16 O00443,P50542,Q9NUQ7,Q7LGA3 4 +Aplasia hypoplasia of the skin 0.388505763978567 1.1896251416839767 0.234193759595819 1.0 0.9724039045715794 55 Q13126,Q9H4L7,Q13363,P48651,P53701,P28340,O14802,P21281,Q15334,Q13315,O15111,Q15392,Q6ZXV5,Q8NCH0,Q9Y619,O00170,O75844 17 +Posterior embryotoxon 0.4905827358601683 1.1866328146923817 0.2353724864387247 1.0 0.9724039045715794 17 Q12948,Q92766,P53701,Q96DF8,P50542,Q92890,Q7LGA3 7 +Atrophy degeneration involving the caudate nucleus 0.7077066513884331 1.1856584817326294 0.2357571969016789 1.0 0.9731118326412288 4 P00846 1 +Vascular calcification 0.6359595255749642 1.1843197943195942 0.2362864961291246 1.0 0.9744147457910828 5 P04062 1 +Titubation 0.5814097666999781 1.1807457313110137 0.2377037484872839 1.0 0.9770990375182024 8 Q99720 1 +Rhizomelia 0.5299445405120221 1.1770947076398743 0.2391577072363619 1.0 0.9770990375182024 11 Q9UBM7,P42345,Q14739,Q15392,O75718 5 +Prolonged bleeding following procedure 0.8752599256121223 1.1746694488383038 0.2401269866570428 1.0 0.9770990375182024 3 O43826 1 +Irregular femoral epiphysis 0.7046586776245092 1.1735826754603491 0.2405622238016325 1.0 0.9770990375182024 4 Q9NUQ7 1 +Status epilepticus with prominent motor symptoms 0.874751491053679 1.1728475737519213 0.2408569364062911 1.0 0.9770990375182024 3 P50542,Q13510 2 +Aplasia hypoplasia of the nipples 0.4818394370716807 1.1725863953380709 0.2409617077018742 1.0 0.9770990375182024 18 P07437,Q9Y223 2 +Joint hemorrhage 0.8628684995031483 1.172471606450716 0.241007765228673 1.0 0.9770990375182024 2 P49257 1 +Sensory axonal neuropathy 0.5141237522592005 1.1685696077121404 0.2425770791880019 1.0 0.9781989583319608 13 Q9Y6X9,P22626,Q96RR1,Q8IV08 4 +Hallux valgus 0.5066283420529596 1.1684514784526894 0.2426247004645145 1.0 0.9781989583319608 14 Q96J02,Q15233,P04062,Q6UX04,P21281,Q15056,Q93009 7 +Recurrent pancreatitis 0.8733007504479047 1.1676504288762168 0.2429477998530371 1.0 0.9781989583319608 3 P03886 1 +Brain imaging abnormality 0.4317214005606954 1.1673102770786543 0.2430850898484098 1.0 0.9781989583319608 34 P07602,Q09472,Q96CW1,Q9NZJ7,O14802,P03886,P00403,P53597,Q9BT22,P21912,Q96AX1,Q93009 12 +Cranial asymmetry 0.6318929244745596 1.1670026476472732 0.2432093003175715 1.0 0.9781989583319608 5 Q13363,O14802 2 +Emg axonal abnormality 0.8612123219609179 1.1659868461844485 0.2436197637580655 1.0 0.978566268150362 2 Q9Y223 1 +Underdeveloped supraorbital ridges 0.5343728427305785 1.1653013892188242 0.2438970169859757 1.0 0.978566268150362 10 Q6PGP7,Q08J23,Q9ULC3,P16435,P50542 5 +Cerebral palsy 0.5779852704028587 1.164795853817789 0.2441016375943505 1.0 0.978566268150362 8 P35270,Q9BVA1 2 +Abnormality of the calf musculature 0.5132244035613833 1.1636769619892913 0.2445549490796836 1.0 0.978566268150362 13 Q9NR77 1 +Focal t2 hyperintense brainstem lesion 0.486578200992429 1.162785164157923 0.2449166779182672 1.0 0.978566268150362 17 Q9Y6M9,Q96CU9,P03886 3 +Abnormal phalangeal joint morphology of the hand 0.4254661991700612 1.162359082502528 0.2450896365920813 1.0 0.978566268150362 39 Q9H4L7,P27635,Q15042,O14802,Q9NPF4,P16435,Q9Y6X9,Q13509,Q9Y619,Q6DKJ4,O75844 11 +Synostosis of metacarpals metatarsals 0.8717519129271952 1.162104026563024 0.2451932120539099 1.0 0.978566268150362 3 P16435 1 +Atypical absence seizure 0.860218615435576 1.1620978677879186 0.2451957134455997 1.0 0.978566268150362 2 P43034 1 +Upper limb postural tremor 0.8709426934155216 1.159207112675978 0.2463717729169556 1.0 0.9798669776756932 3 P04350 1 +Meningocele 0.5263733595501862 1.1585082632078376 0.246656681523419 1.0 0.9798669776756932 11 Q92766,Q9Y5P6,Q96ST3,Q8TAA9,Q92890 5 +Undetectable electroretinogram 0.8702990544101714 1.1569034113071366 0.247311824855082 1.0 0.9798669776756932 3 P50897 1 +Abnormal renal pelvis morphology 0.3945662888369575 1.1515626525770404 0.2495008358107182 1.0 0.9798669776756932 52 Q09472,Q08J23,P49454,Q15042,O14802,P16435,P21281,P23786,P50542,Q8NCH0,O75718,Q6DKJ4 12 +Calcification of the aorta 0.6989170894583586 1.1508510557078533 0.2497935163193354 1.0 0.9798669776756932 4 P04062 1 +Concentric hypertrophic cardiomyopathy 0.868279973896195 1.149679410151875 0.2502759377697945 1.0 0.9798669776756932 3 P03886 1 +Adult onset 0.361115083376127 1.1491720128025067 0.2504850588344323 1.0 0.9798669776756932 61 Q96T60,P07602,Q8IV08,P04062,O15118,Q9Y4G8,Q14566,Q9Y223 8 +Abnormal anterior chamber morphology 0.6982772848747875 1.1483194264170298 0.2508367223612904 1.0 0.9798669776756932 4 Q8NCH0 1 +Proximal muscle weakness 0.3691806478494164 1.14694906265081 0.2514026736425108 1.0 0.9798669776756932 59 Q13126,Q9BPX6,P10253,Q9Y5P6,Q9BQT8,Q96RR1,Q9Y6X9,P00846,Q99720,Q13510 10 +Abnormal brainstem mri signal intensity 0.4633934828571273 1.1449625467180895 0.2522246724476327 1.0 0.9798669776756932 20 Q9Y6M9,P03886,Q96CU9 3 +Ascites 0.4301055514124167 1.1448108754094095 0.2522875092918983 1.0 0.9798669776756932 24 P04062,O15118,Q14108,Q01844,P08236,Q14739 6 +Abnormal enchondral ossification 0.4298508799058664 1.1429833690865026 0.2530454961353947 1.0 0.9798669776756932 24 Q9UBM7,Q8NCM8,Q13363,O00116,P50542,Q9NUQ7,P08236,Q14739,Q9Y619,P38435 10 +Thick hair 0.6003061824774382 1.1415128166261284 0.2536565815563407 1.0 0.9798669776756932 6 Q96AX1 1 +Congenital nonbullous ichthyosiform erythroderma 0.6964284940359842 1.141005732687316 0.2538675373988308 1.0 0.9798669776756932 4 P19447,P04062 2 +Areflexia of lower limbs 0.4698004608271514 1.140105412596042 0.2542423872344554 1.0 0.9798669776756932 19 Q16637,Q9NR77,Q9H6K4,Q96RR1,Q9Y223 5 +Female sexual dysfunction 0.6959942950390944 1.139288457324068 0.2545828611276171 1.0 0.9798669776756932 4 O00170,Q8WWQ0 2 +Abnormal ilium morphology 0.4759915551671824 1.1369297616420972 0.2555676493460317 1.0 0.9798669776756932 18 Q09472,P16278,P50542,Q96AX1,Q8TAA9 5 +Distal lower limb amyotrophy 0.5221726720092704 1.1366448361616923 0.2556867886750951 1.0 0.9798669776756932 11 Q9NR77,Q9Y6X9 2 +Premature thelarche 0.8535939052666464 1.1362090501873712 0.2558690837726822 1.0 0.9798669776756932 2 Q09472 1 +Abnormality of the periorbital region 0.3620200254819752 1.1342927264035638 0.2566717791896264 1.0 0.9798669776756932 63 P28070,Q08J23,P16435,P07437,P50542,Q96AX1,Q9Y223,P62266,O00170,Q8IWS0,Q7LGA3 11 +Multifocal cerebral white matter abnormalities 0.6236274201115943 1.1318310651114185 0.257705464650372 1.0 0.9798669776756932 5 P10253 1 +Intracellular accumulation of autofluorescent lipopigment storage material 0.8630209962410993 1.130883240215759 0.2581042382874847 1.0 0.9798669776756932 3 O14773 1 +Kinetic tremor 0.4274662397197422 1.128965103308119 0.2589125550432207 1.0 0.9798669776756932 33 P07602,Q15233,Q9Y3C8,Q8N2K0,Q9NZJ7,O14802,Q14108,P19447,O43681 9 +Thyroiditis 0.5937537600883142 1.1280462258712285 0.2593003973717258 1.0 0.9798669776756932 7 Q96J02,O43826 2 +Adenoma sebaceum 0.6931228690596629 1.127935730765591 0.2593470625412131 1.0 0.9798669776756932 4 P43246,P52701 2 +Angiofibromas 0.6931228690596629 1.127935730765591 0.2593470625412131 1.0 0.9798669776756932 4 P43246,P52701 2 +Decreased muscle mass 0.4864598349093292 1.127776429146171 0.2594143503021495 1.0 0.9798669776756932 16 Q13363,P04066,Q9Y487,Q8TAA9,Q8NCH0 5 +Cutaneous photosensitivity 0.4448286385600131 1.1257693596123757 0.2602631566863294 1.0 0.9798669776756932 22 Q9UBM7,Q9Y3Z3,Q08J23,P04080,P22830,Q14108,P12004,P19447 8 +Ventricular hypertrophy 0.4234502134154604 1.1253317549245594 0.2604484782660154 1.0 0.9798669776756932 37 O95630,P10253,Q15233,O75880,P03886,P00403,P23786,Q96RR1,O43772,O00170,O75844 11 +Osteopetrosis 0.8506127856906303 1.124581611018409 0.260766369708064 1.0 0.9798669776756932 2 Q15392 1 +Elbow ankylosis 0.8506127856906294 1.1245816110184048 0.2607663697080657 1.0 0.9798669776756932 2 P16435 1 +Humeroradial synostosis 0.8506127856906294 1.1245816110184048 0.2607663697080657 1.0 0.9798669776756932 2 P16435 1 +Missing ribs 0.5262727524259531 1.1240342799874232 0.2609984836238195 1.0 0.9798669776756932 10 Q8TAA9,P21281 2 +Toxemia of pregnancy 0.5928396937192606 1.123970042294479 0.2610257351186071 1.0 0.9798669776756932 7 Q14739,P49366,O43772 3 +Pleural effusion 0.5431579447430855 1.1114788067045376 0.2663623074915764 1.0 0.986190539492083 9 Q9NZ08 1 +Paroxysmal involuntary eye movements 0.4716160243926106 1.110244379089648 0.2668937338292114 1.0 0.986190539492083 18 Q9Y6M9,Q96CU9,P03886 3 +Pancreatic islet cell hyperplasia 0.856630065777865 1.1080826587301194 0.2678261194476108 1.0 0.9869536625034978 3 P53985 1 +Short femur 0.6180052781253272 1.1079335522357543 0.2678905139617036 1.0 0.9869536625034978 5 O00116,O14802,Q9UHX1 3 +Simplified gyral pattern 0.4255244422286056 1.10458952334428 0.2693374927545879 1.0 0.9903486005806432 30 Q13509,Q86XL3,Q13885,Q9NPF4 4 +Cutaneous syndactyly 0.5158505540482864 1.1037446552335408 0.2697039187969352 1.0 0.9904344393178915 11 Q9H4L7,Q09472,P27635,P21281,O15111 5 +Arteriosclerosis 0.5020610139707996 1.1029395325435838 0.2700534250457607 1.0 0.9908132485626864 13 P16278,O15118 2 +Elbow flexion contracture 0.4329540209991881 1.1020066518559364 0.2704587797545592 1.0 0.9908132485626864 23 O00443,Q7LGA3,P23786,P16435 4 +Cupped ear 0.4944537710663239 1.1006653467106604 0.2710423335136476 1.0 0.9921541598360728 14 P42892,P63241,Q15392,P49711 4 +Apraxia 0.3607065366118285 1.0999269998646135 0.2713639296466388 1.0 0.992534789990633 60 P04062,Q9BVA1,Q7Z460,O14773,P05067,Q13509,P42858,Q7LGA3 8 +Primary adrenal insufficiency 0.5142324682272644 1.095326137252966 0.2733737806590723 1.0 0.9982848787718408 11 P16435,O75879 2 +Hypersplenism 0.5392826236852499 1.0926289185934146 0.2745567603378895 1.0 0.9984757747317335 9 Q14108,P07602,P04062 3 +Hepatosplenomegaly 0.4215276895575783 1.0883518917627664 0.2764397904330615 1.0 0.9984757747317335 34 P04062,P16278,P10619,Q96AX1,Q9Y223 5 +Deposits immunoreactive to beta amyloid protein 0.851037636089156 1.0881714212836795 0.2765194386097627 1.0 0.9984757747317335 3 Q9Y223 1 +Diaphyseal thickening 0.8508946322067676 1.087662798114823 0.2767439966571374 1.0 0.9984757747317335 3 Q14739,P08236 2 +Limited hip movement 0.4794438872758317 1.0869016444452952 0.2770802795019622 1.0 0.9984757747317335 16 O75844,Q7LGA3 2 +Ectodermal dysplasia 0.8403444849287891 1.0846490515853051 0.2780771210672976 1.0 0.9984757747317335 2 P21281 1 +Hypoplasia of the musculature 0.6125022116589012 1.084567877933482 0.278113088417786 1.0 0.9984757747317335 5 Q9NR77 1 +Decreased calvarial ossification 0.6820427018541776 1.0841998383843408 0.2782762033202108 1.0 0.9984757747317335 4 O75844 1 +Absent hair 0.5115379860566769 1.0813100419370982 0.2795592219977951 1.0 0.9984757747317335 11 P62304,O75844 2 +Neoplasm of the rectum 0.4980188262056054 1.0809513113964382 0.279718772165173 1.0 0.9984757747317335 13 Q9UPY3,P28340,P43246,Q07864,P52701 5 +Multifactorial inheritance 0.5361663015162479 1.077476961433422 0.2812672378417513 1.0 0.9984757747317335 9 P42892,P35611 2 +Recurrent paroxysmal headache 0.536048233874995 1.0769030254445988 0.2815235913493392 1.0 0.9984757747317335 9 P03886 1 +Coarse facial features 0.3623149480929636 1.076700312224514 0.2816141728496992 1.0 0.9984757747317335 68 O00443,P16278,P04066,P54802,P21281,P10619,P08236,Q96AX1,P15586,Q9Y223,O00170,Q8IWS0,Q7LGA3 13 +Aplasia hypoplasia of the capital femoral epiphysis 0.6101975883680146 1.0747912841225589 0.2824681835338936 1.0 0.9984757747317335 5 Q7LGA3 1 +Abnormality of the ribs 0.3697425467981352 1.073747580507718 0.2829358297595852 1.0 0.9984757747317335 57 Q8NCM8,P48651,O75718,P16278,P54802,O14802,P16435,P21281,P15586,Q9UHX1,Q8TAA9,Q14739,Q9Y619,Q6DKJ4,O75844 15 +Abnormal pupil morphology 0.5033843133520823 1.073046812454096 0.2832501130672278 1.0 0.9984757747317335 12 Q13363,P26196,Q9NR77,Q01968,Q12948 5 +Absent earlobe 0.8370321298443217 1.0718094345483025 0.2838056346407134 1.0 0.9984757747317335 2 Q09472 1 +Long penis 0.837032129844321 1.0718094345483 0.2838056346407145 1.0 0.9984757747317335 2 O00170 1 +Incoordination 0.3628559188446053 1.0705554617445316 0.2843693586417064 1.0 0.9984757747317335 69 P07602,Q09472,P04062,P27635,O43681,Q9Y5P6,Q9NZJ7,O14773,Q9NR77,O75503,P00846,P42858,Q13510 13 +Abnormality of fontanelles 0.4011238917912333 1.0657018192778016 0.2865584549990467 1.0 0.9984757747317335 46 P37287,Q15436,Q09472,P48651,P42345,Q08J23,O14802,P16435,Q9BT22,O15111,P50542,Q9Y487,Q8NCH0,O75718,Q9BPU6,Q9Y619,O75844 17 +Elevated diastolic blood pressure 0.8353759523020918 1.0653978024357753 0.2866959508235562 1.0 0.9984757747317335 2 P42892 1 +Elevated mean arterial pressure 0.8353759523020918 1.0653978024357753 0.2866959508235562 1.0 0.9984757747317335 2 P42892 1 +Elevated systolic blood pressure 0.8353759523020918 1.0653978024357753 0.2866959508235562 1.0 0.9984757747317335 2 P42892 1 +Fatty replacement of skeletal muscle 0.5788760757570355 1.0617645230082715 0.2883425992059543 1.0 0.9984757747317335 7 Q9Y223 1 +Aplasia hypoplasia of the earlobes 0.5076738817135955 1.0612171643381638 0.2885912206749426 1.0 0.9984757747317335 11 P10586,Q09472,O14802,Q92766 4 +Abnormal brainstem morphology 0.3791628098957204 1.0605104642310366 0.2889124319335046 1.0 0.9984757747317335 85 Q9BVA1,Q7Z460,Q9Y6M9,Q86Y39,P03886,P07437,Q13509,Q13885,Q96CU9 9 +Square face 0.8340510102683032 1.060272527374835 0.2890206338321546 1.0 0.9984757747317335 2 Q09472 1 +Branchial cyst 0.8340510102683032 1.060272527374835 0.2890206338321546 1.0 0.9984757747317335 2 P27635 1 +Retinal degeneration 0.3646374224308865 1.059238088581818 0.2894913627235307 1.0 0.9984757747317335 58 P50897,P04062,O14773,Q6UX04,O75503,P68371,P42858,Q7LGA3 8 +Intestinal polyp 0.4631916047745606 1.0588702297804509 0.2896588839326077 1.0 0.9984757747317335 18 Q9UPY3,P42345,P28340,P42892,O43684,P43246,Q07864,P52701 8 +Constriction of peripheral visual field 0.4628563882128002 1.056826518608204 0.2905907692087639 1.0 0.9984757747317335 18 P00846,Q6UX04 2 +Colorectal polyposis 0.5547731878084868 1.056793049027379 0.2906060473354785 1.0 0.9984757747317335 8 Q9UPY3,Q07864,P28340 3 +Abnormal sacrum morphology 0.4172242867670696 1.0550172188821338 0.2914174497419073 1.0 0.9984757747317335 34 P49366,P27635,Q08J23,P04066,P49711,Q8TAA9,P43034,Q14739,Q6DKJ4 9 +Abnormality of pancreas physiology 0.4134042044512274 1.0542981604846722 0.2917464306777715 1.0 0.9984757747317335 38 Q9NZ08,P09601,P03886,P00403,O43826,P53985,Q14739 7 +Chorioretinal hypopigmentation 0.8323948327260728 1.0538710706863712 0.2919419493238782 1.0 0.9984757747317335 2 Q96AX1 1 +Restless legs 0.6743313375646367 1.0538408986837806 0.2919557651790339 1.0 0.9984757747317335 4 Q709C8,P07196 2 +Abnormal tongue morphology 0.3556518494665474 1.0529819655139132 0.2923492576550974 1.0 0.9984757747317335 64 O00443,P10253,P48651,Q9NQT5,Q9Y5P6,P16278,P04066,Q15042,Q9Y4R8,P21281,O15111,Q96AX1,Q9Y6X9,Q6DKJ4,O00170,O75844,Q7LGA3 17 +Paralysis 0.3992459406088681 1.0492517115256437 0.2940622842229035 1.0 0.9984757747317335 46 Q9NR77,P10253,Q15165 3 +Vitiligo 0.5758139673596645 1.048144164742445 0.2945721908949188 1.0 0.9984757747317335 7 P03886 1 +Flat face 0.4328467028984139 1.0447051820825544 0.2961592490489104 1.0 0.9984757747317335 22 P07437,P50542,P08236,Q9Y487 4 +Lethal skeletal dysplasia 0.829744948658499 1.0436408931652692 0.2966515657236133 1.0 0.9984757747317335 2 Q14739 1 +Abnormal pelvis bone ossification 0.829744948658499 1.0436408931652692 0.2966515657236133 1.0 0.9984757747317335 2 Q14739 1 +Lateral clavicle hook 0.8297449486584977 1.043640893165265 0.2966515657236153 1.0 0.9984757747317335 2 Q9Y619 1 +Thoracic hypoplasia 0.4173710173033687 1.0431205632657392 0.2968924580388612 1.0 0.9984757747317335 28 O00443,Q15436,P42345,Q14739,P04062,P16435,Q9UHX1,O75718,Q9Y223 9 +Microcornea 0.4171450846363863 1.042687266989448 0.2970931570030548 1.0 0.9984757747317335 27 Q15042,P49711,Q13045,P07437,Q8NCH0 5 +Type i diabetes mellitus 0.5038382090686497 1.0412830238253374 0.2977442131568086 1.0 0.9984757747317335 11 Q96J02,P50851,P00403,P03886 4 +Disproportionate short limb short stature 0.4534109804651562 1.0377007716555924 0.2994093856007338 1.0 0.9984757747317335 19 Q9UBM7,Q8NCM8,P42345,O75718,O00116,Q15392,Q14739,Q6DKJ4,Q7LGA3 9 +Schizophrenia 0.4465273790897999 1.0368701080739646 0.2997963965498667 1.0 0.9984757747317335 20 P07602,P04062,Q92766,Q9NZJ7,P16615,O43681 6 +Enterocolitis 0.8363543884693914 1.0360980923902443 0.3001563820919275 1.0 0.9984757747317335 3 P49748 1 +Birth length greater than 97th percentile 0.8274263000993722 1.0347020955367536 0.3008080571140168 1.0 0.9984757747317335 2 P37287 1 +Abnormal circulating cholesterol concentration 0.4157370153091445 1.0345938258002925 0.3008586386252747 1.0 0.9984757747317335 26 P07602,Q9NZJ7,Q15800,O43826,Q15392,P42858 6 +Abnormal lymphocyte morphology 0.4157808857578567 1.033127752284466 0.3015441174555597 1.0 0.9984757747317335 31 Q6PGP7,P28070,P50851,P16278,Q7L590,P04066,O95470,Q13315 8 +Degeneration of the striatum 0.668740922394405 1.0318803003248085 0.3021281955440531 1.0 0.9984757747317335 4 P42858 1 +Limb dystonia 0.4820558206289299 1.031667167382925 0.3022280632370426 1.0 0.9984757747317335 14 Q99720 1 +Seborrheic dermatitis 0.5267324955046444 1.031654308027712 0.3022340894470305 1.0 0.9984757747317335 9 P37287,P29401,Q92766 3 +Ankyloglossia 0.5718306919997908 1.0304408183385392 0.3028031202914722 1.0 0.9984757747317335 7 Q6DKJ4,O75844 2 +Abnormal macrophage morphology 0.5996987226163154 1.0303305296471998 0.3028548722730835 1.0 0.9984757747317335 5 P16278 1 +Symphalangism affecting the phalanges of the hand 0.8337824764233771 1.0270107548275116 0.3044153998964685 1.0 0.9984757747317335 3 Q15233 1 +Proximal symphalangism 0.8337824764233771 1.0270107548275116 0.3044153998964685 1.0 0.9984757747317335 3 Q15233 1 +Thick cerebral cortex 0.59857146287806 1.0255652650980087 0.3050965471871065 1.0 0.9984757747317335 5 Q9Y487 1 +Impaired vibratory sensation 0.4148985042926872 1.024882002785948 0.3054188674778917 1.0 0.9984757747317335 28 Q15120,O14773,O14802,Q9NR77,Q9Y6X9,P00846,Q96RR1 7 +Abnormality of earlobe 0.4147749219901153 1.0239705524235132 0.3058491840644364 1.0 0.9984757747317335 28 Q09472,Q92766,P53701,O14802,P16435,P10586,Q15392,Q92890,Q8IWS0,Q7LGA3 10 +Ankle clonus 0.4999970165389276 1.021333790936206 0.3070963221356679 1.0 0.9984757747317335 11 P07602,P42858 2 +Hiatus hernia 0.5243454120406867 1.0200733364558658 0.3076936812124597 1.0 0.9984757747317335 9 Q9NPF4 1 +Thickened calvaria 0.5243388927134705 1.0200417167601872 0.3077086764128507 1.0 0.9984757747317335 9 P16278,Q15233,P48651,Q8IWS0 4 +Telangiectasia 0.4116847991641056 1.017530521207217 0.3089011204752858 1.0 0.9984757747317335 35 P28340,P03886,O43826,P10619,Q14739,Q8IZA0,P00846 7 +Gastrointestinal obstruction 0.479344528100141 1.0165918835826575 0.3093476168997191 1.0 0.9984757747317335 14 P42892 1 +Skin dimple 0.4137244651546636 1.016223862712127 0.3095227954629806 1.0 0.9984757747317335 28 P49366,P27635,Q08J23,P49711,Q8TAA9,P43034,Q6DKJ4 7 +Cerebral dysmyelination 0.568600556554233 1.0160980635602308 0.3095826911020189 1.0 0.9984757747317335 7 P18074,Q9NZJ7,P07602,P19447 4 +Unsteady gait 0.3975386821500981 1.0159760633608714 0.3096407852926104 1.0 0.9984757747317335 45 Q8NC96,P49366,Q09472,Q7Z460,Q9NR77,O75503,Q5JRX3,Q9H6K4,P42858 9 +Nonketotic hypoglycemia 0.6643876240137034 1.014810928661859 0.3101959632209801 1.0 0.9984757747317335 4 P23786 1 +Dysgenesis of the hippocampus 0.8221265319642322 1.014316614571951 0.3104316986114108 1.0 0.9984757747317335 2 Q13509 1 +Psychosis 0.4135310525149068 1.0142948856588203 0.3104420637109166 1.0 0.9984757747317335 29 O15118,P03886,P00403,Q5JRX3,O00170 5 +Lactose intolerance 0.8300836766309411 1.0139610931723146 0.3106013177026605 1.0 0.9984757747317335 3 Q14566 1 +Short nail 0.6638509347958952 1.0127085950253525 0.3111993712233727 1.0 0.9984757747317335 4 O75844 1 +Abnormal lumbar spine morphology 0.5227150198096208 1.012167285603885 0.3114580751882099 1.0 0.9984757747317335 9 P08236,P04062 2 +Acquired abnormal hair pattern 0.6636831486377059 1.0120514329782158 0.3115134621868594 1.0 0.9984757747317335 4 O75844 1 +Sclerocornea 0.5221638751041956 1.0094954326691246 0.3127370909554401 1.0 0.9984757747317335 9 Q9H3P2,P49454,Q13363,P53701 4 +Abnormality of the musculature of the hand 0.4105894976179699 1.008977444239139 0.312985451738468 1.0 0.9984757747317335 35 Q15120,P61254,P61313,Q9NR77,Q9BQT8,P62244,P18077,Q9Y223,Q9Y6X9 9 +Deformed sella turcica 0.6623779405148114 1.0069409256757904 0.3139631634305608 1.0 0.9984757747317335 4 P08236 1 +J shaped sella turcica 0.6623779405148114 1.0069409256757904 0.3139631634305608 1.0 0.9984757747317335 4 P08236 1 +Carpal synostosis 0.5940482702888488 1.0064631273309148 0.3141928401915033 1.0 0.9984757747317335 5 P16435 1 +Synostosis of carpals tarsals 0.5940482702888488 1.0064631273309148 0.3141928401915033 1.0 0.9984757747317335 5 P16435 1 +Rapidly progressive 0.543689837383296 1.0053704629190687 0.3147184971109982 1.0 0.9984757747317335 8 Q14108 1 +Congenital hypothyroidism 0.6619328212663216 1.005198710318859 0.3148011760719651 1.0 0.9984757747317335 4 P21281 1 +Abnormal lateral ventricle morphology 0.4119070632661863 1.004337799125982 0.3152158200964252 1.0 0.998494980884376 27 Q05639,Q09472,Q9BVA1,Q15042,Q13509 5 +Absence of subcutaneous fat 0.5691366942249123 1.0042770929255067 0.315245071798619 1.0 0.998494980884376 6 O14802,O75844 2 +Poor speech 0.3737840747874144 1.002921589606949 0.3158986949381803 1.0 0.999177494877282 85 Q15233,Q96N66,Q2M389,P04350,Q9Y5P6,Q08J23,Q9NZ01,P21281,Q96F86,Q9NUQ7,P08236,Q9Y487,Q13509,Q96CU9 14 +Lipoma 0.5680926972015723 0.999699436141937 0.3174559850312177 1.0 0.9999967425520304 6 Q8TAA9 1 +Abnormal morphology of the limbic system 0.5423577561763082 0.9992001003119028 0.3176977672994707 1.0 0.9999967425520304 8 Q13509,Q05639 2 +Abnormal labia minora morphology 0.564760864271331 0.9990659949806904 0.3177627226922193 1.0 0.9999967425520304 7 Q15042,P16435 2 +Dilation of lateral ventricles 0.4469280851083774 0.9972351294880136 0.3186503930498987 1.0 1.0 19 Q13509,Q15042,Q9BVA1 3 +Juvenile onset 0.4022056433409322 0.9958216316707034 0.3193368179837719 1.0 1.0 41 P16278,O14773,O15118,Q9NR77,Q14566 5 +Abnormality of visual evoked potentials 0.440031993434157 0.995283538482795 0.3195983817049121 1.0 1.0 20 P07602,Q9NZJ7,Q15042,Q6UX04,O75503 5 +Heterogeneous 0.4047372739232882 0.9941386831980964 0.3201553548742715 1.0 1.0 39 Q09472,P03886,Q9NR77,P05067,P00846,O75844 6 +Abnormal circulating pyruvate family amino acid concentration 0.4251967761185342 0.9929947492845018 0.3207125133072384 1.0 1.0 22 P00846,P03886 2 +High frequency sensorineural hearing impairment 0.6587012046573539 0.9925600262565476 0.3209244132695381 1.0 1.0 4 O75844 1 +Pulmonary fibrosis 0.4386825513895343 0.9866500673743904 0.3238142165101521 1.0 1.0 20 P09601,Q8IZA0,P04062 3 +Anencephaly 0.4666579516292363 0.9847155452295612 0.3247638147284157 1.0 1.0 15 Q9Y3Z3,Q92766,P21281,Q8TAA9,Q92890 5 +Abnormal metacarpal morphology 0.4085647156322682 0.9824716092177808 0.3258675630474259 1.0 1.0 26 P16278,Q6UX04,P16435,P08236,Q14739 5 +Aplasia hypoplasia of the distal phalanges of the hand 0.4085785817559279 0.9782969065880236 0.3279274994338217 1.0 1.0 28 Q8IWS0,O95630,P42345,Q6UX04,P16435,P21281,Q6DKJ4,O75844,P38435 9 +Aortic valve calcification 0.8189510858979333 0.9748320636327832 0.3296435695077364 1.0 1.0 3 O75844 1 +Myopathic facies 0.5370353128456982 0.9745715485558618 0.329772832312496 1.0 1.0 8 Q9Y5P4 1 +Flexion contracture of digit 0.3538425361250876 0.973188505135496 0.3304596227576852 1.0 1.0 69 Q96J02,Q9H4L7,P27635,P42892,Q15042,O14802,Q9NPF4,P49711,P16435,P50542,Q9Y619,O75844,Q6DKJ4,Q13509,P63241,Q9Y4P8,Q8IWS0,Q9Y6X9 18 +Hepatic failure 0.3903193395028904 0.9711122419594276 0.3314923882943028 1.0 1.0 46 P04062,O15118,P22830,P03886,P23786,P00846,O43772 7 +Ventricular septal hypertrophy 0.8098708181517082 0.9674405936404828 0.3333238253239199 1.0 1.0 2 P46976 1 +Upper limb amyotrophy 0.4588839552800629 0.9672658588923976 0.3334111463789466 1.0 1.0 16 Q9NR77,Q9BQT8,Q9Y6X9 3 +Anal stenosis 0.5841700032232652 0.96486269015806 0.3346135910526362 1.0 1.0 5 Q12948,Q08J23 2 +Convex nasal ridge 0.4416831370352028 0.964535010739816 0.3347777643330714 1.0 1.0 19 Q96J02,Q09472,P28340,O14802,O75844 5 +Abnormality of humoral immunity 0.3747522969429384 0.9642271891868052 0.3349320357402983 1.0 1.0 52 Q14108,P09601,P04062,Q96AX1 4 +Small anterior fontanelle 0.8088771116263687 0.9636572545380158 0.3352177916677252 1.0 1.0 2 Q9Y619 1 +Infantile axial hypotonia 0.5125931273917166 0.963166620915835 0.3354639130967363 1.0 1.0 9 P07602,Q13509 2 +Hirsutism 0.3437535096580963 0.9605939075737424 0.3367563931860045 1.0 1.0 61 Q09472,Q9BW83,P27635,P16278,Q15042,P54802,P16435,P07437,P08236,Q96AX1,P15586,Q9Y223 12 +Thickened nuchal skin fold 0.5339377155861345 0.9602587337861996 0.3369250133195289 1.0 1.0 8 P21281 1 +Contractures of the joints of the lower limbs 0.3714221426463933 0.960145001362037 0.3369822424685642 1.0 1.0 53 P48651,P27635,Q8N2K0,Q9Y5P6,Q08J23,Q96AY3,Q86XL3,P23786,P63241,Q99720,Q8IZA0,Q8IWS0,Q7LGA3 13 +Peripheral axonal degeneration 0.3537201668164715 0.9600062715770492 0.3370520585294292 1.0 1.0 70 Q9BPX6,P07602,Q8IV08,P03886,P00403,Q9Y6X9,P00846,Q13509 8 +Hypopigmented skin patches 0.4122954989623467 0.9582642489094728 0.3379295266134787 1.0 1.0 23 P07602,P42345,Q92766,P53701,Q9NZJ7,P19447,Q92890,Q8IZA0 8 +Dyspareunia 0.8072209340841366 0.9573578213020644 0.3383866799314798 1.0 1.0 2 O00170 1 +Overtubulated long bones 0.8137089323331639 0.9564899287254008 0.3388247701821116 1.0 1.0 3 O75844 1 +Primitive reflex 0.5549351394985319 0.9555808199779996 0.3392840554643925 1.0 1.0 7 P26358,Q13509 2 +Proportionate short stature 0.4054459975822914 0.9551768727761556 0.3394882592527246 1.0 1.0 31 P48651,P53701,P16278,Q07864,Q15392,P29401,P10619,Q14739,Q9Y619 9 +Prominent superficial blood vessels 0.4872156498348787 0.9550888836489208 0.3395327500556733 1.0 1.0 11 O75844,P48651,Q9Y487 3 +Hyperextensible skin 0.4744935378769879 0.9532353266342684 0.3404708511838419 1.0 1.0 13 P04062 1 +Muscular hypotonia of the trunk 0.3627509878521068 0.9525206320569752 0.3408330074200472 1.0 1.0 79 Q8NC96,Q9Y3Z3,P49366,P07602,O75880,Q15233,Q96N66,Q08J23,P04350,Q9NZJ7,P35270,P42858,Q6ZXV5,P43034,Q13509,Q2TAA5,Q9Y5P4 17 +Left ventricular systolic dysfunction 0.5571628144033985 0.9518818602424431 0.3411569001342742 1.0 1.0 6 O75844 1 +Triphalangeal thumb 0.4392579878458585 0.9494304120459388 0.3424017488750697 1.0 1.0 19 Q15427,P61254,P61313,P21281,P08708,P62244,P18077 7 +Flat occiput 0.473149788812264 0.9459623754023578 0.3441677769402913 1.0 1.0 13 Q13509,P62266 2 +Osteolysis 0.4029752088592512 0.9456459721915772 0.3443291878363193 1.0 1.0 25 Q14108,O75844 2 +Angiokeratoma 0.8101391650099676 0.9440322533636962 0.345153166624105 1.0 1.0 3 P16278,P04066 2 +Abnormal atrioventricular conduction 0.4787461701063712 0.9423643050794396 0.3460061556783951 1.0 1.0 12 P49748 1 +Decreased activity of mitochondrial complex i 0.402380264696155 0.9401891949152088 0.3471205231772098 1.0 1.0 34 Q9UBX3,Q9Y6M9,P03886,Q70HW3,Q96CU9 5 +Osteosarcoma 0.4246048853876842 0.9401420016032468 0.347144726868595 1.0 1.0 21 Q13126,P61254,P61313,P62244,P18077 5 +Decreased absent ankle reflexes 0.4780996888365741 0.9389472563875632 0.347757824884408 1.0 1.0 12 Q96RR1,Q9H6K4,Q9Y223 3 +Jaundice 0.3661811226157175 0.938615634069624 0.3479281229230713 1.0 1.0 54 P00374,Q9Y3Z3,O15118,P49711,P50542,P49748 6 +Ventricular tachycardia 0.4715988341585124 0.9375721154814458 0.3484643469972879 1.0 1.0 13 P23786,P49748 2 +Shyness 0.6444161538632508 0.93692474901507 0.3487972675483537 1.0 1.0 4 Q15233,Q06787 2 +Decreased circulating igg subclass level 0.8015899304405458 0.9359988252491084 0.3492737925583833 1.0 1.0 2 Q13315 1 +Decreased specific antibody response to vaccination 0.8015899304405457 0.9359988252491064 0.3492737925583844 1.0 1.0 2 P50851 1 +Abnormal libido 0.8074884029158493 0.934799649842928 0.349891560081883 1.0 1.0 3 O00170,P42858 2 +Abnormality of bone marrow cell morphology 0.3715051407248945 0.9335793045793952 0.3505209448290283 1.0 1.0 52 Q14108,P00374,P04062 3 +Long toe 0.4886673261143928 0.9330522091193962 0.3507930125924585 1.0 1.0 10 P23786,O14802,Q9Y223 3 +Microretrognathia 0.4564977594535074 0.9270046882992344 0.3539241000981847 1.0 1.0 15 Q16625,Q9Y4R8,Q8NCH0,P27635 4 +Short columella 0.8047400479906998 0.9252438204540256 0.3548390942026702 1.0 1.0 3 P49711 1 +Abnormal shoulder physiology 0.8039480218249344 0.922493227871312 0.3562713611247972 1.0 1.0 3 O75844 1 +Coxa valga 0.4285808497859649 0.922120713687502 0.3564656135913036 1.0 1.0 20 P16278 1 +Erythema 0.4460345688069847 0.9215633409887896 0.3567563876159427 1.0 1.0 17 P53701,P22830,P03886,P00403,O00170 5 +Epileptic spasm 0.3445001440008214 0.9201127165330294 0.3575138597108278 1.0 1.0 65 Q96T60,Q05639,Q9UBX3,Q2M389,Q08J23,Q96N66,Q9NZ01,P03886,Q96F86,Q9NUQ7,P43034,P00846,Q13510 13 +Difficulty running 0.4618308239083227 0.9194458573199834 0.3578624128244327 1.0 1.0 14 Q9BPX6,Q9Y6X9 2 +Punctate cataract 0.8028495692511859 0.9186808882090002 0.3582625091600688 1.0 1.0 3 Q15436,Q9H6K4 2 +Polar cataract 0.8028495692511775 0.91868088820897 0.3582625091600846 1.0 1.0 3 P50542,Q7LGA3 2 +Mesomelia 0.5459949325703765 0.9161642182368036 0.3595807697372328 1.0 1.0 7 Q9UBM7,Q6DKJ4,Q14739 3 +Hoarse cry 0.7959589267969558 0.9147354200562474 0.3603305449044964 1.0 1.0 2 Q13510 1 +Impaired social interactions 0.3837818890127404 0.913994049387134 0.3607199724925394 1.0 1.0 46 Q09472,Q96CW1,Q9Y6M9,Q86Y39,Q9NPL8,P03886,Q8TB37,Q9UHX1,Q96RR1,Q13509,Q2TAA5,Q96CU9 12 +Abnormality of the endometrium 0.5023116716742277 0.9135755497578776 0.3609399187693527 1.0 1.0 9 P43246,Q07864,P52701,P28340 4 +Broad distal phalanx of finger 0.5477150555255792 0.9107335350639146 0.3624357900539685 1.0 1.0 6 Q7LGA3 1 +Bulbous nose 0.3887103990320514 0.9092713423697918 0.3632069137882661 1.0 1.0 43 P42892,P21281,P16435,P23786,Q02252 5 +Abnormal spermatogenesis 0.4781344280949327 0.9081952324425216 0.363775082523412 1.0 1.0 11 Q13315,P04062,P16435 3 +Abnormality of the metaphysis 0.3849868923057515 0.907529853258468 0.3641266699924999 1.0 1.0 45 Q13126,O00443,P16278,Q6UX04,P50542,Q9NUQ7,Q96AX1 7 +Distal upper limb amyotrophy 0.4659542638559278 0.9070781263005874 0.3643654843021155 1.0 1.0 13 Q9NR77,Q9BQT8 2 +Abnormal urine cytology 0.3949082332852428 0.9059149568022762 0.3649808671134391 1.0 1.0 38 Q14108,P09601,P04062 3 +Arnold chiari type i malformation 0.5700834522842746 0.905876052976188 0.3650014606633833 1.0 1.0 5 Q15233,Q09472,Q6UX04 3 +Aplasia hypoplasia of the femur 0.4654514719907971 0.9043653076041462 0.365801727597058 1.0 1.0 13 O00443,O00116,O14802,P53597,P50542,Q9UHX1 6 +Cutaneous melanoma 0.792646571712494 0.9022745026650186 0.3669110665704891 1.0 1.0 2 P11802 1 +Abnormal aortic valve physiology 0.395946886855002 0.9002195973800263 0.3680033989945028 1.0 1.0 36 Q9NZ08,P04062,P16278,Q6ZXV5,O75844 5 +Enlarged kidney 0.5204816644056831 0.898296954502952 0.3690272557529166 1.0 1.0 8 P23786,Q96AX1 2 +Bilateral tonic clonic seizure with generalized onset 0.5418936584054302 0.898138320746102 0.3691118113535907 1.0 1.0 7 Q13510,P04062 2 +Lack of skin elasticity 0.4512910403794413 0.8975064749699441 0.3694487198786063 1.0 1.0 15 Q15334,O00170,O75844,P28340 4 +Decreased plasma carnitine 0.4640706895619813 0.8969184087536535 0.369762456270146 1.0 1.0 13 P23786,O43772,P49748 3 +Absent epiphyses 0.5444105258764782 0.8963886610181849 0.370045221163455 1.0 1.0 6 Q7LGA3 1 +Diastasis recti 0.7962226640159261 0.8957429195426475 0.3703900819866788 1.0 1.0 3 Q8NCH0,P42345 2 +Widow s peak 0.7962226640159263 0.8957429195426475 0.3703900819866788 1.0 1.0 3 P29372,P21281 2 +Interictal eeg abnormality 0.3572522356650652 0.8936035919697064 0.3715340238277287 1.0 1.0 79 Q8NC96,Q96T60,Q05639,Q9UBX3,Q96N66,Q2M389,P27635,Q08J23,Q9NZ01,Q14108,O75503,Q96F86,Q9NUQ7,P43034,Q2TAA5,Q13885 16 +Elevated serum acid phosphatase 0.7955739124355636 0.8935032233885414 0.3715877467099435 1.0 1.0 3 P07602 1 +Renal agenesis 0.3722023257758636 0.8909702909733039 0.3729451086504494 1.0 1.0 50 Q9UBM7,O00443,Q86XL3,Q00534,Q8TAA9,P16435,Q15058,P62244,Q8WWQ0,Q15427,P61313,P18077,P61254,P08708,P46783,Q15392,Q9UHX1,P35606,Q7LGA3 19 +Abnormal tissue metabolite concentration 0.4625053559193544 0.8884819161172074 0.3742815791094362 1.0 1.0 13 P07602,P37287,Q9NZJ7,P50542,O43681,P06280 6 +Abnormal nerve conduction velocity 0.3915510987581762 0.8874414067420052 0.3748412989298333 1.0 1.0 39 Q96T60,P07602,Q15120,Q9NZJ7,Q9NR77,Q9Y6X9,O43681,Q99720 8 +Shoulder girdle muscle weakness 0.4679833236778114 0.8855947363399402 0.3758359489981839 1.0 1.0 12 Q9NZJ7,P07602,Q96RR1,Q9Y223 4 +Broad alveolar ridges 0.7880092745942435 0.8848904261737581 0.3762157320848383 1.0 1.0 2 P21281 1 +Facial capillary hemangioma 0.7880092745942424 0.8848904261737532 0.3762157320848409 1.0 1.0 2 P16435 1 +Stereotypy 0.340955962974073 0.8818385218358191 0.3778641367226674 1.0 1.0 65 Q09472,Q05639,Q08J23,Q2M389,Q96N66,Q9NZ01,Q96F86,Q9NUQ7,Q13509,Q9Y5P4 10 +Athetosis 0.4549221733868802 0.8812864199926134 0.3781628143962925 1.0 1.0 14 Q96CU9 1 +Zonular cataract 0.4783178606001283 0.8808927459897526 0.3783758740907654 1.0 1.0 10 Q15436,Q9H6K4,P08670 3 +Knee flexion contracture 0.3949884585461923 0.8808221907526698 0.3784140669900326 1.0 1.0 27 P48651,P27635,Q96AY3,Q9Y5P6,Q86XL3,P23786,Q7LGA3 7 +Decreased circulating cortisol level 0.5377643358994442 0.8800292435045729 0.3788434677336705 1.0 1.0 7 P16435 1 +Abnormal autonomic nervous system physiology 0.3952674709295257 0.8799005183146567 0.3789132039211886 1.0 1.0 32 P07602,P04062,Q9NZJ7,P42892,Q13509 5 +Small basal ganglia 0.5161939854980897 0.8786388799239203 0.3795971078794025 1.0 1.0 8 P00846 1 +Total anomalous pulmonary venous return 0.7909433405088377 0.877548591043626 0.38018873838837 1.0 1.0 3 Q15392 1 +Opisthotonus 0.3926260808279186 0.8763204637030642 0.3808558433191447 1.0 1.0 24 P07602,P04062,Q9NZJ7,Q2TAA5,P43034,Q99720 6 +Severe viral infection 0.6286439386232212 0.8760217271757353 0.3810182222620928 1.0 1.0 4 Q7L590 1 +Genu varum 0.4767969151376046 0.8732505249206236 0.3825265410556615 1.0 1.0 10 Q9Y281,Q96HY6,Q9NUQ7,Q9Y619 4 +Caesarian section 0.6265693701838171 0.8680585879560426 0.3853622600986965 1.0 1.0 4 O14802,O60313 2 +Vascular skin abnormality 0.3886572381421851 0.8657546572906205 0.3866247194636505 1.0 1.0 113 Q14108,Q13315,Q9Y487,P10619,Q14739,P00846,P49257,Q8IZA0,P38435,Q13126,Q9Y3Z3,P16278,P04066,P03886,P00403,Q16625,O43826,O75844,P51648,Q08J23,O00170,P04062,P53701,P28340,P22830,Q8NCH0 26 +Interrupted aortic arch 0.7827095064590983 0.8651142976368099 0.386976057983698 1.0 1.0 2 Q96DF8 1 +Temperature instability 0.5132245617842286 0.8650527508526888 0.387009836382125 1.0 1.0 8 Q9NZJ7,P07602,Q2TAA5 3 +Reduced brain n acetyl aspartate level by mrs 0.7872913256903311 0.8650058291109483 0.3870355894035124 1.0 1.0 3 P07602 1 +Abnormal brain n acetyl aspartate level by mrs 0.7872913256903311 0.8650058291109483 0.3870355894035124 1.0 1.0 3 P07602 1 +Abnormal brain choline level by mrs 0.7872913256903311 0.8650058291109483 0.3870355894035124 1.0 1.0 3 P07602 1 +Absent eyebrow 0.5367824801490948 0.8633823409059357 0.3879272853770374 1.0 1.0 6 O75844 1 +Scaling skin 0.5127156312407553 0.8627266445290082 0.388287779248269 1.0 1.0 8 O75844 1 +Brain neoplasm 0.7820470354422031 0.8626493770446598 0.3883302734046725 1.0 1.0 2 P28340 1 +Panhypogammaglobulinemia 0.5583514795184332 0.8571222716464327 0.3913773137550169 1.0 1.0 5 P19447,Q6PGP7 2 +Abnormal visual fixation 0.6234765319535231 0.856209421494057 0.3918819521848236 1.0 1.0 4 P04062 1 +Clonus 0.3921809961609457 0.8555090904441615 0.3922693740772502 1.0 1.0 31 P07602,Q9Y5P6,Q9NZJ7,Q99720,P42858 5 +Vacuolated lymphocytes 0.7842707758473898 0.8546596600460932 0.392739589059804 1.0 1.0 3 P16278 1 +Abnormal epiphyseal ossification 0.4559713800987062 0.8533385628845919 0.3934715808071451 1.0 1.0 13 Q9UBM7,O00116,P50542,P08236,Q14739,P38435 6 +Exercise induced myalgia 0.4897293878164571 0.8532198723368001 0.3935373851346004 1.0 1.0 9 P23786 1 +Vertical supranuclear gaze palsy 0.4892494312664649 0.8509262355313011 0.3948103300220316 1.0 1.0 9 Q96RR1,O15118 2 +Short chin 0.4723262871676655 0.8508261779882718 0.3948659175544153 1.0 1.0 10 P42345,O75844,Q08J23 3 +Dyschromatopsia 0.5338222025207136 0.8506169003641103 0.3949821982193431 1.0 1.0 6 Q9H6K4 1 +Impaired tactile sensation 0.5306119849501577 0.8487676680666274 0.3960105843371009 1.0 1.0 7 Q9NR77 1 +Progressive spastic paraplegia 0.3894404937503908 0.8484410687566073 0.3961923790368435 1.0 1.0 25 P00846 1 +Abnormal circulating proteinogenic amino acid derivative concentration 0.3892258178917964 0.8469046257086249 0.3970482839665243 1.0 1.0 25 P00846,P03886 2 +Abnormality of the biliary system 0.3849389039561732 0.8464575805367965 0.3972975283425146 1.0 1.0 111 P00374,Q9Y3Z3,P07602,Q13510,P04062,O43681,Q9NZJ7,P04066,P09601,O15118,P22830,P49711,Q14108,P50542,P49748,Q14739,Q9Y223 17 +Myoclonic seizure 0.3647696417348643 0.8456445946053053 0.397751040112599 1.0 1.0 51 P37287,P07602,Q05639,P04062,Q96N66,Q9NZJ7,P16278,P03886,O75503,P43034,P00846,Q13510 12 +Hypoplastic female external genitalia 0.4420001661878582 0.8450413010390154 0.3980877798079416 1.0 1.0 15 P49711,Q6DKJ4,P16435 3 +Hypokinesia 0.4544111475860377 0.8449655142005499 0.3981300938041263 1.0 1.0 13 Q2TAA5,P42858,P04062 3 +Abnormal circulating fatty acid concentration 0.4162840445570233 0.8439123404945077 0.3987183917584618 1.0 1.0 20 P23786,O43772,O75880,P49748 4 +Abnormal cortical gyration 0.3939892946293596 0.8438602342875623 0.3987475116264862 1.0 1.0 121 Q9BVA1,Q9Y5P6,Q86XL3,Q15042,Q9NZ01,Q9Y487,Q13885,Q2M389,P07437,Q6ZXV5,P43034,Q08J23,P23786,Q9NUQ7,Q96F86,Q13509,Q96T60,Q96N66,Q9NPF4,P21281,P50542,Q15392 22 +Delayed ability to sit 0.4413904362379043 0.8416071309396322 0.4000078964474542 1.0 1.0 15 P10253,Q13509 2 +Furrowed tongue 0.5540297108470491 0.8392630563976898 0.4013217095562076 1.0 1.0 5 Q15042 1 +Increased intracranial pressure 0.446065954899372 0.8325608329920797 0.4050924561479676 1.0 1.0 14 Q9NZ08,P07602,Q9NZJ7,P43246,P52701 5 +Limited elbow movement 0.3886633891865626 0.8318242596583123 0.4055081484071405 1.0 1.0 33 O00443,P16435,P23786,Q9H6K4,Q7LGA3 5 +Abnormality of upper limb joint 0.3852526072585084 0.8298885387335395 0.4066018055411109 1.0 1.0 113 O00443,Q15042,P49711,Q8IZA0,Q09472,P16278,P16435,Q9NR77,O75844,P23786,Q9NUQ7,Q9H6K4,Q9Y6X9,Q13509,Q6DKJ4,Q96AY3,P42892,Q9NPF4,P50542,Q15392,Q9Y223,Q7LGA3 22 +Abnormal arterial physiology 0.387373595140599 0.8291787288065657 0.4070032795682539 1.0 1.0 26 Q9NZ08,Q9Y3Z3,O00443,P05067,O75844 5 +Pigmentary retinopathy 0.375867302785567 0.8290794632614057 0.4070594437743553 1.0 1.0 45 Q9BW83,Q9Y5P6,P03886,P00403,P50542,Q9Y6X9,P00846,Q96CU9 8 +Dermatological manifestations of systemic disorders 0.3426009633118266 0.8286818804868346 0.4072844414814633 1.0 1.0 71 P00374,Q9Y3Z3,O15118,P49711,P50542,P49748,Q14739,O43772,O75844 9 +Coarse hair 0.4196565520839966 0.8278807865536348 0.4077380170389437 1.0 1.0 19 P54802,Q9Y5P4,Q9Y487,Q96AX1,P15586 5 +Abnormal shape of the occiput 0.3865044284967365 0.8274453172761206 0.4079847039163491 1.0 1.0 25 P37287,P21281,P50542,O15111,Q13509,P62266 6 +Depression 0.3714045416242191 0.8261861894730199 0.4086984812256324 1.0 1.0 99 P07602,Q15165,P04062,P50897,Q96N66,Q2M389,Q9NZJ7,Q08J23,P03886,Q9NZ01,P00403,Q96F86,Q9NUQ7,O43681,O00170,P42858 16 +Unilateral renal agenesis 0.4134310369727725 0.8258403350364846 0.4088946700674303 1.0 1.0 20 Q9UBM7,Q15427,Q86XL3,P16435,Q00534,O43379,Q15058,Q9UHX1,P35606,Q7LGA3 10 +Poor gross motor coordination 0.7755231769676139 0.8248463572315838 0.4094588243089947 1.0 1.0 3 O75503 1 +Abnormal platelet volume 0.5251088651431198 0.8248147461333356 0.4094767734847897 1.0 1.0 7 Q14739 1 +Abnormal rib cage morphology 0.3430223215525508 0.8215851381585663 0.411313050562724 1.0 1.0 72 Q8NCM8,P48651,O75718,P16278,P04066,P54802,O14802,P16435,P21281,P15586,P08236,Q9UHX1,Q96AX1,Q14739,Q9Y619,Q8TAA9,Q6DKJ4,O75844 18 +Vaginal atresia 0.7707850281550248 0.8210007078444427 0.4116458650238099 1.0 1.0 2 P16435 1 +Abnormality of globe size 0.3540201956081844 0.8209048544100318 0.4117004657516332 1.0 1.0 54 Q92766,Q96CW1,P53701,Q9Y5P6,P49454,Q15042,O15347,Q9NPF4,O43684,P07437,O15111,P19447,Q02252,Q9UHX1,Q92890,Q96I36 16 +T cell lymphoma 0.6138463947965127 0.8194991325378549 0.4125016966780843 1.0 1.0 4 P52701 1 +Abnormal endocardium morphology 0.44939909627608 0.8181227867034248 0.4132870786969329 1.0 1.0 13 Q9NZ08,P04062 2 +Delayed cranial suture closure 0.3870646887387882 0.8174309575308691 0.4136821902742125 1.0 1.0 30 Q15436,P48651,Q09472,Q08J23,P16435,Q9Y487,Q8NCH0,O75718,O75844 9 +Abnormal gastrointestinal motility 0.385656509244895 0.8168313831192603 0.4140247948895035 1.0 1.0 26 P11802,P00403,P03886 3 +Multiple joint contractures 0.4224813492338994 0.811965519482671 0.4168114169091645 1.0 1.0 18 Q9Y3Z3,O75844 2 +Spastic paraparesis 0.4170610664735316 0.811881351843591 0.4168597158353377 1.0 1.0 19 Q9H6K4,P04062 2 +Agenesis of corpus callosum 0.3598540487095056 0.8103480119636596 0.4177401883074876 1.0 1.0 89 Q8NCM8,Q13363,Q9BVA1,Q9Y5P6,Q15022,Q86XL3,Q15042,Q00534,Q9BPU6,Q09472,P49454,P03886,P00403,P29372,P48651,P23786,Q13509,P53701,Q69YQ0,O14802,P19447,P78318,P35606,Q15392,Q9UHX1,Q7LGA3 26 +T lymphocytopenia 0.5216964718143933 0.8100098845828931 0.4179344947225794 1.0 1.0 7 Q7L590 1 +Vasculitis 0.5009298353006852 0.8090777947944051 0.4184703998639292 1.0 1.0 8 Q9NZ08 1 +Cardiac diverticulum 0.770433758593424 0.8076086333901192 0.4193159151808741 1.0 1.0 3 P52701 1 +Foam cells 0.6099732273656726 0.804818853923724 0.4209242201047001 1.0 1.0 4 P16278 1 +Aplasia hypoplasia involving the skeletal musculature 0.4999602088421277 0.8046843383946285 0.421001859559154 1.0 1.0 8 Q9NR77 1 +Left ventricular hypertrophy 0.3823927594779046 0.8036245153646336 0.4216138604144273 1.0 1.0 24 P10253,Q15233,O75880,P03886,P00403,O00170 6 +Abnormal sternal ossification 0.6095736357028574 0.8033072120392846 0.421797190473075 1.0 1.0 4 Q9Y619 1 +Tissue ischemia 0.41559499401635 0.8028564358303775 0.4220577182388241 1.0 1.0 19 Q9NZ08,O00443,O75844 3 +Chronic oral candidiasis 0.6093010167113591 0.802276221657263 0.4223931939593344 1.0 1.0 4 P02786 1 +Irregular epiphyses 0.5216427767555225 0.7983876940671492 0.4246455422888169 1.0 1.0 6 Q9NUQ7 1 +Abnormal gallbladder morphology 0.3844649239946075 0.798196258226968 0.4247566084778813 1.0 1.0 30 P07602,P04062,Q9NZJ7,P22830,Q9Y223 5 +Slow saccadic eye movements 0.4566368567040058 0.7980623695457192 0.4248342973603209 1.0 1.0 11 Q8IV08 1 +Congenital nystagmus 0.414798520768223 0.7979574077655961 0.424895207218779 1.0 1.0 19 P00846,Q7LGA3,P21281 3 +Abdominal distention 0.4027917549805355 0.7978495529419228 0.4249578012398061 1.0 1.0 21 P07602,P04062,Q9NZJ7,O43826,Q01844,Q9Y223 6 +Macrovesicular hepatic steatosis 0.5188670804784232 0.7977640914226104 0.4250074030333182 1.0 1.0 7 P23786 1 +Abnormal lung lobation 0.4334854921895495 0.7972018096059159 0.4253338352403677 1.0 1.0 15 Q92766,O43684,Q92890,O15111,Q9UHX1,Q14739 6 +Abnormal circulating fatty acid anion concentration 0.4289308022209837 0.7943616921520572 0.4269848987554856 1.0 1.0 16 P23786,O43772,P49748 3 +Abnormal subclavian artery morphology 0.7634978469692004 0.7943241346231893 0.4270067573060658 1.0 1.0 2 Q09472 1 +Everted upper lip vermilion 0.7663368129248815 0.7937933165544383 0.4273157641284772 1.0 1.0 3 P04062 1 +Abnormal umbilicus morphology 0.3294123824500252 0.7934199761796927 0.4275331759667313 1.0 1.0 62 Q96T60,Q96DF8,P07437,P08236,Q9Y487,Q8NCH0,Q6DKJ4,O75844 8 +Abnormality of the carpal bones 0.4501734643717319 0.7923766749028384 0.4281410757404538 1.0 1.0 12 Q9NUQ7,P16435 2 +Eeg with focal epileptiform discharges 0.3829606774690309 0.7909387858497122 0.4289797136302105 1.0 1.0 34 Q96T60,Q08J23,Q2M389,Q9UBX3,Q96N66,Q9NZ01,O75503,Q9NUQ7 8 +Progressive sensorineural hearing impairment 0.459293294861524 0.78583670666599 0.4319631588817252 1.0 1.0 10 P03886 1 +Short ribs 0.4955413316787563 0.7847051742391729 0.4326264483673974 1.0 1.0 8 Q14739,Q96HY6,Q8NCM8,Q9Y619 4 +Abnormality of skeletal muscle fiber size 0.4271447941059388 0.7841448972316679 0.432955093531991 1.0 1.0 16 Q9BPX6,P22626,P53597,Q96RR1,Q9Y223 5 +Epispadias 0.6039871235055494 0.7822329106155925 0.4340777064980616 1.0 1.0 4 P48651,P53701 2 +Avascular necrosis of the capital femoral epiphysis 0.602899038812819 0.7781415054278503 0.4364855964186938 1.0 1.0 4 Q9NUQ7 1 +Abnormal pleura morphology 0.3997315394301498 0.77803965335137 0.4365456368207019 1.0 1.0 21 Q8NCH0,Q9NZ08,P08236 3 +Obsessive compulsive trait 0.6028678069511068 0.7780241330631147 0.4365547862355083 1.0 1.0 4 Q93009,O75503 2 +Widely spaced teeth 0.3817223111171139 0.7779461178515426 0.4366007789060329 1.0 1.0 30 Q15233,P16278,P21281,P08236,O00170,Q9Y5P4 6 +Stroke 0.3817829955203539 0.7778980071074469 0.4366291432482854 1.0 1.0 31 P00403,O00443,O75844,P03886 4 +Hypertriglyceridemia 0.3930102195273419 0.7769404503731026 0.437193904611262 1.0 1.0 22 P28070,P35573,P28340,Q7L590,P22830,O95470,O43826,Q13045 8 +Mandibular aplasia 0.6018015893284565 0.7740193902239824 0.4389193247290843 1.0 1.0 4 O15111,P53701 2 +Craniosynostosis 0.3764105220982056 0.774016104905012 0.4389212675104827 1.0 1.0 40 Q86UE8,Q6UX04,P21281,P49711,Q8NCH0 5 +Macular degeneration 0.4291289794784932 0.7728336164408437 0.4396208557839596 1.0 1.0 15 P50897,P04062,Q13510 3 +Sarcoma 0.3541868412651043 0.7709283619892768 0.4407493949528702 1.0 1.0 52 P63167,Q13126,Q9UPY3,Q09472,P61254,P61313,O43684,Q92804,P21281,Q01844,P52701,Q15392,P62244,P18077 14 +Abnormal parietal bone morphology 0.5369163272453488 0.7691707553051316 0.441791948959902 1.0 1.0 5 Q09472 1 +Abnormal cd4 cd8 ratio 0.6001605298976398 0.7678639907452028 0.4425679925578514 1.0 1.0 4 P17812 1 +Symptomatic seizures 0.4914218230512585 0.7661467636257766 0.4435889805952038 1.0 1.0 8 O43826 1 +Abnormal soft palate morphology 0.329014561816487 0.7653037287374654 0.4440907042109481 1.0 1.0 64 Q15436,Q6PGP7,P48651,Q15233,Q96DF8,Q69YQ0,P61254,O14802,P61313,Q9BUF5,P21281,P78318,Q15392,P62244,P18077,Q9Y619,P62266,Q6DKJ4 18 +Elevated circulating alanine aminotransferase concentration 0.4546751074120949 0.7629672703539946 0.4454829154371951 1.0 1.0 10 P10253,O15382 2 +Hyperkinetic movements 0.4491344914587681 0.7600175949369609 0.4472440676632405 1.0 1.0 11 P07602,Q9Y223 2 +Lymphopenia 0.3835036086930392 0.7596689836914328 0.4474524730431268 1.0 1.0 23 Q6PGP7,P28070,P50851,Q7L590,O95470,Q13315 6 +Aspiration pneumonia 0.3825720021320988 0.7533078040271238 0.4512649703027249 1.0 1.0 23 P43034,P16278,P04062,P21281 4 +Primitive neuroectodermal tumor 0.4216781462876954 0.7529621452401482 0.4514726619726634 1.0 1.0 16 P43246,Q9UPY3,P07437,P52701 4 +Hemivertebrae 0.4475405223554206 0.7519664345098863 0.452071244352644 1.0 1.0 11 P63241,P21281,Q9UHX1,P16435 4 +Abnormal ossification involving the femoral head and neck 0.7537035088039845 0.7515579351376519 0.4523169479278703 1.0 1.0 3 Q9NUQ7 1 +Hemolytic anemia 0.3781708351741032 0.751083233041418 0.452602565791059 1.0 1.0 31 P09601,P00390 2 +Distal muscle weakness 0.327474104155712 0.7488082162208985 0.4539728068832422 1.0 1.0 64 Q96T60,Q9Y5P6,Q9NR77,Q9Y6X9,P00846,Q99720,Q9Y223 7 +Perseveration 0.5096208968131486 0.7473647024043955 0.4548434459525436 1.0 1.0 6 Q93009,Q9BSH4,Q15233 3 +Premature birth 0.3746166663156061 0.744557689471358 0.4565391539540235 1.0 1.0 38 P49366,P04062,O75879,Q9NPF4,P50542,O75844 6 +Dysuria 0.5083041373532491 0.7418124150525863 0.4582009974670762 1.0 1.0 6 O00170 1 +Abnormal circulating progesterone level 0.5079450126780837 0.7402994441017376 0.4591183181986202 1.0 1.0 6 Q9NR50,Q13144,P49770,P16435 4 +Decreased circulating progesterone 0.5079450126780837 0.7402994441017376 0.4591183181986202 1.0 1.0 6 Q9NR50,Q13144,P49770,P16435 4 +Overgrowth 0.5049893638603287 0.7381338634803171 0.4604331075175061 1.0 1.0 7 Q9UPY3,P37287 2 +Atlantoaxial abnormality 0.7488302775615876 0.7354229357073586 0.462081957773147 1.0 1.0 3 Q8NCH0 1 +Exercise intolerance 0.376011143896986 0.7351448525737748 0.4622512806750434 1.0 1.0 32 Q9Y2R0,Q9Y5P6,Q9H2D1,P03886,P00403,P23786,Q96RR1 7 +Restlessness 0.3714423943134841 0.7339694415870072 0.4629673626575261 1.0 1.0 40 P42892,Q15165,P42858,P04062 4 +Abnormality of the fetal cardiovascular system 0.7482270979064825 0.7334322423267694 0.4632948401300876 1.0 1.0 3 P16435 1 +Insomnia 0.4215627030389967 0.7307173075280776 0.4649518417311267 1.0 1.0 15 Q13509 1 +Adenocarcinoma of the colon 0.4088510196159629 0.7304899576933808 0.4650907491646678 1.0 1.0 18 P28340,P61254,P61313,P08708,P62847,Q07864,P46783,P62244,Q07020,P18077,P46777 11 +Cerebellar malformation 0.3443303489360733 0.7278029362993198 0.4667342268352714 1.0 1.0 54 Q8NCM8,Q09472,Q15233,Q9Y5P6,Q6UX04,P15291,P16435,O14802,O43684,P07437,P23786,P21281,Q9Y487,Q8TAA9,Q9NQT5 15 +Bone pain 0.3918056970526805 0.7269716974827983 0.4672432938245532 1.0 1.0 21 Q14108,P07602,P04062 3 +Abnormality on pulmonary function testing 0.4315994223127369 0.7236106459958032 0.4693048036719065 1.0 1.0 13 P16278 1 +Kyphoscoliosis 0.3490038816265469 0.7226568821747399 0.4698907120832181 1.0 1.0 52 Q96T60,Q96AY3,P04350,Q15042,Q9NR77,Q8NCH0,Q13509,O75844 8 +Papule 0.4159427047367525 0.7204056975365432 0.4712752430477733 1.0 1.0 16 O75844 1 +Large intestinal polyposis 0.4613745365054288 0.7191570382789296 0.4720441666887076 1.0 1.0 9 Q9UPY3,Q07864,P28340 3 +Upper limb muscle weakness 0.3774590827819771 0.718496755691284 0.4724510475795609 1.0 1.0 23 Q9Y6X9,P00846 2 +Abnormality of epiphysis morphology 0.3532510982361764 0.7183531291419539 0.4725395790397702 1.0 1.0 50 Q9UBM7,O00443,Q8NCM8,Q13363,Q09472,Q6NUQ1,O00116,P16278,P16435,P50542,Q9NUQ7,P08236,Q14739,Q9Y619,Q7LGA3,P38435 16 +Orthostatic hypotension 0.4247955151220275 0.7167518853394645 0.4735272047379673 1.0 1.0 14 Q9NZJ7,P07602,P04062 3 +Hypoglycemic seizures 0.4993262758464414 0.7140318440772959 0.475207488671034 1.0 1.0 7 O43826 1 +Limb muscle weakness 0.3371342480988305 0.7132413805811784 0.4756964040888023 1.0 1.0 76 Q13126,Q96T60,Q14739,Q9Y5P6,Q16637,Q9NR77,Q9BQT8,Q96RR1,Q9Y6X9,P00846,Q9Y223,Q99720,Q13510 13 +Subcapsular cataract 0.4989040246205179 0.7122406494802705 0.4763157691524058 1.0 1.0 7 Q9H6K4,Q12948 2 +Gray matter heterotopia 0.3723930108275811 0.7113426435434009 0.4768719322744816 1.0 1.0 29 Q9UBM7,Q9UEY8,Q9BVA1,Q9Y5P6,Q86XL3,P46821,Q06787,Q00534,Q15058,Q2TAA5,Q6ZXV5,P43034,P35606,Q9BSJ2 14 +Fever 0.3411644305977668 0.7112180552216308 0.4769491217913173 1.0 1.0 80 Q9NZ08,P10253,Q9Y3Z3,P07602,P28070,Q9NZJ7,Q7L590,P03886,Q9NR77,P00403,P23786,P00846 12 +Hypoplasia of teeth 0.3949440432943829 0.7096776153539811 0.4779040764084477 1.0 1.0 20 O00443,P51648,Q09472,Q15436,P19447,O75844 6 +Abnormality of the gallbladder 0.3701412838620583 0.7093264876647848 0.4781218948782249 1.0 1.0 38 Q9UBM7,P07602,Q13363,Q92766,P04062,Q69YQ0,Q9NZJ7,P04066,P22830,Q92890,Q9H3P2,O43681,Q9Y223 13 +Sloping forehead 0.3614946917073475 0.7064785527749651 0.4798905856948126 1.0 1.0 45 Q96KP1,O95630,P26640,Q96T60,Q08J23,Q86XL3,Q9NPF4,O43684,Q16625,P23786,Q00534,Q15003,Q15058,P35606,Q96EK5,Q9BSJ2 16 +Color vision defect 0.4383139725996493 0.7056096273330739 0.4804309355593306 1.0 1.0 11 Q9H6K4 1 +Abnormal exteroceptive sensation 0.3591935772814506 0.7010583681553005 0.4832665901085082 1.0 1.0 46 Q9NZ08,P07602,P54802,Q9NR77,P05067,Q9H6K4,Q9Y6X9,Q8NCH0 8 +Supernumerary spleens 0.4572808474078555 0.7000948105857693 0.4838680964543345 1.0 1.0 9 Q96KP1,P49454,Q13363 3 +Abnormality of the anterior fontanelle 0.3712370030168179 0.699872707408321 0.4840068032126206 1.0 1.0 31 Q15436,Q09472,P42345,Q08J23,O14802,P16435,P50542,O15111,Q9Y487,O75718,Q9BPU6,Q9Y619 12 +Abnormality of the synovia 0.3379238944179877 0.699215133980885 0.4844175940708348 1.0 1.0 78 Q8NCM8,Q13363,Q9Y5P6,P08236,Q9Y487,Q96AX1,Q9BPU6,P16278,P16435,P43034,O75844,Q9Y4R8,Q9NUQ7,O75718,Q96AY3,O14802,Q9NPF4,Q9UHX1,Q9NQT5 19 +Metaphyseal cupping 0.7373690297088596 0.6978493607965822 0.4852714059947083 1.0 1.0 3 P50542 1 +Aplasia hypoplasia of the sacrum 0.7372580488901859 0.6974882140102996 0.4854973127353315 1.0 1.0 3 Q8TAA9 1 +Abnormality of the supraorbital ridges 0.3927564778529574 0.6960642705495647 0.4863885809641652 1.0 1.0 20 Q15436,Q08J23,Q15022,P16435,P50542,Q8IWS0 6 +Protrusio acetabuli 0.736756932679835 0.6958581750631455 0.4865176525555399 1.0 1.0 3 Q96AY3 1 +Breast hypoplasia 0.7363305994681388 0.6944722469988315 0.4873860995454437 1.0 1.0 3 Q9Y619 1 +Abnormality of the tarsal bones 0.3666060698185271 0.692635620698327 0.4885382502816813 1.0 1.0 24 Q9Y4R8,P16435,Q9UHX1,Q14739,O75844 5 +Expressive language delay 0.4302749226514524 0.6897760861976302 0.4903350094015235 1.0 1.0 12 Q13509 1 +Abnormality of the knee 0.3410934888052198 0.6884546889400815 0.4911664946724678 1.0 1.0 82 Q09472,Q96AY3,Q9Y5P6,P16278,Q86XL3,Q9NR77,P23786,Q9NUQ7,P08236,Q6ZXV5,Q13509,Q7LGA3 12 +Malignant genitourinary tract tumor 0.4014960054142309 0.6869482872400781 0.4921153165015508 1.0 1.0 18 P61254,P61313,P08708,P43246,P62847,P46783,P52701,P62244,Q07020,P18077,P46777 11 +Recurrent sinopulmonary infections 0.5161259671478597 0.6856537878231921 0.4929314544556722 1.0 1.0 5 Q9Y487 1 +Telecanthus 0.3642985463551553 0.6849948637087053 0.4933471621258682 1.0 1.0 41 Q86UE8,Q86XL3,P21281,Q96AX1,Q8NCH0,O75844,Q12948 7 +Adenocarcinoma of the intestines 0.3851359298222842 0.684307797499052 0.4937808241902426 1.0 1.0 21 P28340,P61254,P61313,P08708,P43246,Q07864,P62244,P18077 8 +Ulnar deviation of the hand or of fingers of the hand 0.4385039852272439 0.6836993405356607 0.4941650399934016 1.0 1.0 10 Q14739,Q9BPU6,Q15042 3 +Gastritis 0.5771982301959816 0.6829205270820181 0.4946570622484203 1.0 1.0 4 P50851 1 +Emotional lability 0.3446434915493893 0.6822518411734178 0.4950797193196927 1.0 1.0 52 P07602,Q15165,Q09472,Q9NZJ7,O43681,Q13509,Q96CU9 7 +Cutaneous finger syndactyly 0.7323149307063614 0.6814571766835932 0.4955822546003852 1.0 1.0 3 O15111 1 +Shallow acetabular fossae 0.7313680026498919 0.6796772673189448 0.4967088330841678 1.0 1.0 2 Q9NUQ7 1 +Duplication of phalanx of hallux 0.7313680026498908 0.6796772673189403 0.4967088330841707 1.0 1.0 2 Q09472 1 +Lumbar scoliosis 0.7315784731611875 0.679078042333137 0.4970884143717042 1.0 1.0 3 P21281 1 +Dysphagia 0.3753908673114362 0.6781733019051923 0.4976618182460008 1.0 1.0 118 Q14108,Q14739,P00846,Q99720,Q8IZA0,P42858,P04350,O15118,P03886,Q9NR77,P05067,Q9BUF5,Q13510,P07602,Q15233,Q05639,P04062,Q9NZJ7,Q96RR1,P15586 20 +Narrow palate 0.359502001168301 0.6769000404115328 0.4984693784700498 1.0 1.0 44 Q09472,P16435,P21281,Q9NZ01,P23786,P50542,Q9Y223 7 +Ambiguous genitalia 0.3947623328974631 0.6758277801906594 0.4991499946993167 1.0 1.0 19 P53701,O43684,P16435,P21281,Q15392,Q8TAA9 6 +Generalized hyperpigmentation 0.4221943814086342 0.6743165115361206 0.5001101088075421 1.0 1.0 13 O00170,P21281 2 +Abnormal visual electrophysiology 0.3559607995045361 0.673415533476337 0.5006829690758314 1.0 1.0 46 P07602,P50897,O43681,Q9NZJ7,Q15042,Q6UX04,O14773,O75503,P00846 9 +Slender build 0.4269108439130544 0.6726408033422813 0.5011758363566472 1.0 1.0 12 P04350,Q15233 2 +Abnormality of the nasal septum 0.4917103094009191 0.6725473053498661 0.501235335221291 1.0 1.0 6 Q09472,P21281 2 +Abnormality of glycolipid metabolism 0.4894016543277875 0.6721640559270932 0.5014792608979346 1.0 1.0 7 Q9NZJ7,P07602,P06280,O43681 4 +Abnormality of the pubic bone 0.4885705283132123 0.6686809679316777 0.5036990106209225 1.0 1.0 7 Q13363,Q8IZA0 2 +Abnormality of peripheral nerves 0.3621682303523792 0.6678201180379321 0.5042484230442597 1.0 1.0 41 Q96T60,P07602,Q15120,Q9NZJ7,Q9NR77,Q9Y6X9,O43681,Q99720 8 +Corneal scarring 0.7273931765485329 0.6658741551209997 0.5054915412877239 1.0 1.0 2 Q09472 1 +Abnormal shape of the frontal region 0.3551246620375395 0.6656032112897843 0.5056647532713052 1.0 1.0 98 Q96J02,Q8NCM8,Q6UX04,Q13045,Q9Y487,Q14739,Q09472,P16278,P04066,P16435,P43034,P63241,P48651,P42345,O00170,Q6DKJ4,Q15436,Q15233,Q9UPY3,O14802,O43684,P21281,P50542,Q02252,Q15392,Q9Y619,P15586,Q9Y223 28 +Recurrent fever 0.4087890238120886 0.6603244798474861 0.509045623965187 1.0 1.0 15 Q9NR77,P28070 2 +Muscle fibrillation 0.4187356282142872 0.6563239047686785 0.5116157399262002 1.0 1.0 13 Q9BQT8,Q13510,Q16637 3 +Abnormality of the humerus 0.423647080267297 0.6560843774011526 0.5117698357110099 1.0 1.0 12 P48651,O00116,O14802,P16435,P50542 5 +Spastic tetraparesis 0.362976253073241 0.655489509142843 0.5121526386541078 1.0 1.0 26 P07602,Q9Y296,Q9NZJ7,P43034,P00846 5 +Abnormal mitral valve physiology 0.3648899355210132 0.6529553727188402 0.513785049405957 1.0 1.0 33 Q9NZ08,P04062,O75844,P49711 4 +Cerebral hemorrhage 0.4319987107472856 0.652228165635776 0.514253992726353 1.0 1.0 10 P23786 1 +Pneumonia 0.3549530264766939 0.6512799344881017 0.514865798735725 1.0 1.0 45 Q09472,P04062,P16278,P21281,P49748,P43034,Q96AX1 7 +Abnormal renal insterstitial morphology 0.4273359720435052 0.6510769857666718 0.5149967919203702 1.0 1.0 11 P23786 1 +Cyanosis 0.3952644790372017 0.650340967813483 0.5154719996621093 1.0 1.0 18 Q9Y3Z3,O43772,O75844 3 +Sclerosis of skull base 0.7220778851016492 0.6486105733507106 0.5165901195269478 1.0 1.0 3 Q14739 1 +Intracranial hemorrhage 0.3670316762716825 0.6481137065365353 0.5169114094555305 1.0 1.0 23 P04062,P23786,P05067,O75844 4 +Abnormal csf metabolite level 0.3331807812238228 0.6471132609555984 0.5175586433735244 1.0 1.0 55 Q9Y3Z3,Q9Y6M9,Q86Y39,P03886,P00846,Q96CU9 6 +Protuberant abdomen 0.4854378627618181 0.6467432592432589 0.5177981205679598 1.0 1.0 6 Q9Y223,P04062 2 +Spina bifida 0.363820910420249 0.6455525856786037 0.5185691522699944 1.0 1.0 31 Q09472,Q92766,Q08J23,Q10713,Q9Y5P6,Q96ST3,Q9ULC3,P21281,Q15056,Q9UHX1,Q8TAA9,P09884,Q92890 13 +Abnormal distal phalanx morphology of finger 0.3569705891803668 0.644698865445352 0.5191223517020451 1.0 1.0 43 Q8IWS0,O95630,Q09472,P42345,Q15042,Q6UX04,P16435,P21281,Q7LGA3,Q6DKJ4,O75844,P38435 12 +Tongue fasciculations 0.4252089897736513 0.6406000523120194 0.5217825655807169 1.0 1.0 11 Q9BQT8,Q13510,Q16637 3 +Abnormal talus morphology 0.3888187345296077 0.6401057429388644 0.5221038556337745 1.0 1.0 19 Q9Y4R8,Q9UHX1,O75844,P16435 4 +Tall stature 0.3236731774179257 0.6393951370303046 0.5225659117376353 1.0 1.0 58 P37287,Q9UPY3,Q13363,Q15233,Q9Y296,P04350,Q15022,O00170,O14802,P16435,Q15334,P43034,Q8NCH0,P42858,Q7LGA3 15 +Abnormality of corneal size 0.3603353221203262 0.638454068628212 0.5231781442480041 1.0 1.0 39 Q13363,Q9Y5P6,P49454,Q15042,O15347,P49711,Q13045,P07437,P19447,Q9H3P2,Q8NCH0 11 +Abnormality of the upper respiratory tract 0.3444131132932214 0.6372817921477338 0.5239413088303251 1.0 1.0 90 Q8NCM8,Q15165,P50851,Q13315,P08236,Q14739,Q09472,P28070,P27635,P16278,P04066,P16435,P07737,P29372,P54802,Q92804,P52701,Q13510,P07602,Q92766,Q69YQ0,Q9NZJ7,O14802,Q9UHX1,Q92890,P15586 26 +B lymphocytopenia 0.5032798268264258 0.6351555668297907 0.5253269593069148 1.0 1.0 5 P50851,Q7L590 2 +Fetal distress 0.3648811778303378 0.6337159548778437 0.5262662106429241 1.0 1.0 23 Q9Y6M9,Q96CU9,P03886,P49711 4 +Choanal stenosis 0.5630906368119345 0.6319905535039134 0.5273930499680954 1.0 1.0 4 P16435 1 +Turricephaly 0.4230910154407825 0.6301985061850934 0.5285647165143623 1.0 1.0 11 P50542,Q92766,P16435 3 +Oral pharyngeal dysphagia 0.4272439429704704 0.6294002792649602 0.5290870352007377 1.0 1.0 10 P42858,Q13510 2 +Cachexia 0.3958996786404331 0.629354627699781 0.5291169151765507 1.0 1.0 17 P07602,Q01844,Q99720,P04062 4 +Joint stiffness 0.3312747809936121 0.6288264586651251 0.5294626760982368 1.0 1.0 55 Q96AY3,P16278,Q15042,P54802,P16435,P08236,Q96AX1,P15586,O75844 9 +Aganglionic megacolon 0.3815485970307297 0.6268771836460081 0.5307397444682316 1.0 1.0 20 Q9UBM7,Q09472,Q92766,P42892,Q92890,Q96EK5 6 +Abnormality of circulating glucocorticoid level 0.4263813679799372 0.6252758205351484 0.5317900466343108 1.0 1.0 10 P16435 1 +Thin ribs 0.421975499590982 0.6247329097448268 0.5321463699210907 1.0 1.0 11 O14802,O75844 2 +Increased circulating lactate dehydrogenase concentration 0.4015549245161057 0.6209333773847184 0.5346434590694511 1.0 1.0 15 Q5JRX3,P37287,P23786,P10253 4 +Pancreatitis 0.374791043253734 0.6188192979523569 0.5360354076985769 1.0 1.0 21 P00403,Q9NZ08,P03886 3 +Aplasia hypoplasia involving the femoral head and neck 0.4569625425781497 0.6141040332251851 0.5391465832347744 1.0 1.0 8 O00443 1 +Dysgenesis of the cerebellar vermis 0.7121563431599929 0.6138475924567894 0.5393160443025471 1.0 1.0 2 P63000 1 +Choreoathetosis 0.3595501161533753 0.6135585666634343 0.5395070701688884 1.0 1.0 32 P00846,P04350 2 +High pitched voice 0.4151575315933535 0.6133593251001663 0.5396387746563478 1.0 1.0 12 Q9Y6X9,O75844 2 +Deviation of the hallux 0.359080692710616 0.6129431722817488 0.5399139157298645 1.0 1.0 30 Q96J02,Q15233,Q09472,P04062,Q9Y296,Q15427,Q6UX04,P21281,Q15056,Q93009,Q9BPU6,Q96PZ0,P42858,Q7LGA3 14 +Large for gestational age 0.4564933277757108 0.6120811486392134 0.5404840693037885 1.0 1.0 8 Q12955,P37287,P42345 3 +Abnormality of the proximal phalanx of the thumb 0.7097287198127588 0.6096669445015406 0.5420824557158539 1.0 1.0 3 Q15233 1 +Aplasia hypoplasia of the patella 0.5564605366665727 0.6084364150254373 0.5428980658446685 1.0 1.0 4 Q96AY3 1 +Impaired visuospatial constructive cognition 0.4739712561445346 0.608146823360777 0.5430900996020005 1.0 1.0 7 P42858,P03886 2 +Abnormal palmar dermatoglyphics 0.3204055801855054 0.6066036055020103 0.5441140069215575 1.0 1.0 58 Q96J02,Q9Y263,Q9H4L7,Q13363,Q09472,P42345,P27635,Q9Y4R8,O00170,Q8NCH0,P49711,P21281,P50542,Q9Y487,Q96AX1,Q9UHX1,P62266,Q6DKJ4 18 +Abnormal erythrocyte enzyme level 0.3917823090020988 0.6060214032252698 0.5445005406589947 1.0 1.0 17 P37287,P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 10 +Hypsarrhythmia 0.3232471299726491 0.6053481641215325 0.5449476853133521 1.0 1.0 57 Q8NC96,Q96T60,Q05639,Q08J23,Q2M389,Q96N66,Q9NZ01,Q96F86,Q9NUQ7,P43034,Q13885 11 +Recurrent aspiration pneumonia 0.4749135124350366 0.6039817747762428 0.5458557592113218 1.0 1.0 6 Q13510,P04062 2 +Aortic regurgitation 0.3536461443641949 0.6030339649769272 0.5464860943206582 1.0 1.0 24 Q9NZ08,O43684,P46821,Q9UHX1,Q6ZXV5,O75844 6 +Central apnea 0.4722779064196213 0.6012107690267071 0.5476996126666835 1.0 1.0 7 P07602 1 +Accessory spleen 0.471773149981633 0.5991469205787601 0.5490749150601695 1.0 1.0 7 P49454,Q13363 2 +Sparse eyelashes 0.3861765238625982 0.5974967441505774 0.550175780105215 1.0 1.0 18 P62304,O75844 2 +Pectus carinatum 0.3570738315128727 0.596619011221411 0.5507617755045038 1.0 1.0 31 Q6DKJ4,P16278,P08236,Q96AX1 4 +Skin appendage neoplasm 0.4932894385184524 0.5965718400963729 0.5507932767644732 1.0 1.0 5 Q9UPY3,Q09472 2 +Absent facial hair 0.4200045142057718 0.5949543804884427 0.5518739654507776 1.0 1.0 10 O75844 1 +Slowly progressive 0.3327383068389598 0.5945063074836762 0.5521735248503838 1.0 1.0 53 Q9NR77,O14773,Q99720,Q8IV08 4 +Shoulder dislocation 0.7047968748774293 0.5943363537595117 0.5522871683641459 1.0 1.0 3 Q6ZXV5 1 +Multiple cafe au lait spots 0.4198215351413696 0.5940889077139527 0.5524526494462811 1.0 1.0 10 Q13315,P43246,P52701,O43684 4 +Spina bifida occulta 0.3854508707229125 0.593308015454957 0.5529750355030836 1.0 1.0 18 Q09472,Q08J23,Q9ULC3,P21281,Q15056,Q9UHX1,Q8TAA9 7 +Limb girdle muscle atrophy 0.4152992769859565 0.5922160680513466 0.5537059110435774 1.0 1.0 11 Q9Y223 1 +Abnormality of amino acid metabolism 0.7052003974826166 0.5905943112215905 0.5547922774456149 1.0 1.0 2 P19447 1 +Flat nasal alae 0.7052003974826166 0.5905943112215905 0.5547922774456149 1.0 1.0 2 P19447 1 +Panniculitis 0.4512128126769979 0.5894200885765358 0.5555795039315314 1.0 1.0 8 Q9Y3Z3 1 +Spinal deformities 0.4712604942074297 0.5893087503850909 0.5556541759753957 1.0 1.0 6 Q9Y223 1 +Hallucinations 0.3486252838762171 0.5869014858412909 0.5572698718293878 1.0 1.0 44 P07602,P50897,P04062,Q9NZJ7,O75503,P05067,P42858 7 +Impaired antigen specific response 0.490154115892691 0.5845991566559701 0.5588172748924651 1.0 1.0 5 P50851 1 +Apnea 0.3244753176009103 0.5804171879813748 0.5616333169994554 1.0 1.0 76 P07602,Q09472,O75880,P04062,Q9NZJ7,Q86Y39,P03886,P23786,P50542,P00846,O43772,O00170,Q9Y223,Q96CU9 14 +Thoracic scoliosis 0.4039359196917518 0.5803017545356096 0.5617111444517175 1.0 1.0 13 Q13509,O75844 2 +Intestinal malrotation 0.3549441925965795 0.5796452280674446 0.5621538863687174 1.0 1.0 33 Q8NCM8,Q13363,Q09472,Q92766,P49454,Q92890,Q15392,Q8NCH0,Q14739 9 +Bifid uterus 0.7018880423981528 0.5796378390717124 0.5621588702468221 1.0 1.0 2 Q09472 1 +Abnormality of limb epiphysis morphology 0.3538533094013585 0.5784828502636009 0.5629381726011993 1.0 1.0 29 O00443,P16435,P50542,Q9NUQ7,Q7LGA3 5 +Poor motor coordination 0.4035209779768458 0.5781952994765053 0.5631322719427221 1.0 1.0 13 O75503,P42858 2 +Poor eye contact 0.3539891629428452 0.5765470519953202 0.5642454760334874 1.0 1.0 36 Q9Y6M9,Q86Y39,Q9NPL8,Q8TB37,P03886,Q9UHX1,Q96RR1,Q96CU9 8 +Abnormality of the parathyroid gland 0.3731130510344743 0.575524947958815 0.5649363230771303 1.0 1.0 20 P00403,Q96DF8,P03886 3 +Diaphragmatic paralysis 0.69772102083564 0.572575714261998 0.5669320071512451 1.0 1.0 3 P10253 1 +Hepatomegaly 0.4004843241992678 0.5695942335471276 0.5689529404531453 1.0 1.0 160 P00374,O00443,Q9Y6M9,P09601,Q14108,P08236,Q96AX1,P00846,Q96CU9,P28070,P16278,O15118,Q86Y39,P03886,O43826,Q01844,O75880,P54802,P23786,P49748,P10253,P07602,P04062,Q9NZJ7,P21281,P50542,O43772,Q9Y223 28 +Abdominal pain 0.3286080526395186 0.5690067623170215 0.5693515508073816 1.0 1.0 81 Q9NZ08,P04062,P42892,Q14108,P23786,Q14566,Q70HW3,Q9Y223 8 +Vertebral fusion 0.428375995487756 0.5684008355488986 0.5697628232061267 1.0 1.0 9 Q9UHX1,Q8TAA9 2 +11 pairs of ribs 0.4641609857739321 0.5682341492424471 0.5698759862790936 1.0 1.0 7 P21281 1 +Diminished movement 0.3663282269020094 0.5659871837796489 0.5714024929043313 1.0 1.0 21 Q2TAA5,P42858,P04062 3 +Arthrogryposis multiplex congenita 0.3525255970404797 0.5655644665656538 0.5716898888684367 1.0 1.0 36 Q8NCH0,P04062,O75844,Q15392 4 +Platyspondyly 0.3519310535065599 0.5649252372824541 0.5721246170518768 1.0 1.0 29 Q96AY3,P16278,Q9NUQ7,P08236,Q14739 5 +Delayed ability to walk 0.3100642217224379 0.5645802513929585 0.5723593009112173 1.0 1.0 64 P49366,Q09472,P27635,Q96N66,Q15042,Q6UX04,Q6ZXV5,Q99720 8 +Abnormality of the lymphatic system 0.3802915247944775 0.5640521926354347 0.5727186124473782 1.0 1.0 136 O00443,P11802,Q7L590,Q14108,P08236,P10619,Q96AX1,Q14739,Q9Y3Z3,P28070,P16278,O15118,Q01844,P54802,Q9NZ08,P10253,P07602,P04062,Q9NZJ7,P21281,P50542,Q15392,P15586,Q9Y223 24 +Postaxial polydactyly 0.390701807689586 0.5626113621048924 0.5736995533602642 1.0 1.0 15 Q9UBM7,Q8NCM8,Q9BW83,Q10713,Q9ULC3,Q14739,P30153,Q9Y263 8 +Abnormality of temperature regulation 0.3458705228755198 0.5597732732508717 0.5756340959206852 1.0 1.0 99 Q9NZ08,P10253,Q9Y3Z3,P07602,P28070,Q14739,Q9NZJ7,P35270,Q7L590,P03886,Q9NR77,P00403,P23786,Q2TAA5,P49748,P00846,O43772 17 +Abnormal nipple morphology 0.3126813013623669 0.5596342570060947 0.5757289334575759 1.0 1.0 59 P10586,P07437,P23786,Q2TAA5,Q9Y5P4,Q9Y223,Q7LGA3 7 +Abnormality of the metacarpal bones 0.3519988665731242 0.5587528272515971 0.5763304206403328 1.0 1.0 32 Q15233,P48651,P16278,Q6UX04,P16435,P08236,Q14739 7 +Cardiomegaly 0.3519851050527242 0.5583307521916064 0.5766185493653984 1.0 1.0 34 Q9Y3Z3,P10253,P04062,O75879,P04066,P54802,P23786,P49748,Q14739 9 +Abnormal delivery 0.3699399272330936 0.5563940346639676 0.5779415159993011 1.0 1.0 20 O75844,O75718,O14802,Q9Y487 4 +Narrow nasal bridge 0.5412702084244521 0.5554977944225972 0.578554218314157 1.0 1.0 4 Q09472 1 +Tonic seizure 0.3528967855858249 0.5543655787527583 0.5793286781370974 1.0 1.0 23 Q96T60,P07602,P27635,Q9NZJ7,P43034 5 +Decreased facial expression 0.3491991112143241 0.554328702639001 0.5793539103707137 1.0 1.0 27 Q9Y5P6,P35270,Q9Y5P4,P04062 4 +Abnormality of the gastric mucosa 0.3986917673253545 0.5537908998435429 0.5797219569296814 1.0 1.0 13 P50851,Q6PGP7,P04062,Q14739 4 +Broad foot 0.4248513606424776 0.5527544611254807 0.58043155527066 1.0 1.0 9 O00170,Q8IWS0,P27635 3 +Cholecystitis 0.4418954100127681 0.5499326101892513 0.5823655962762351 1.0 1.0 8 Q9NZJ7,P07602 2 +Decreased circulating level of specific antibody 0.6898919295602566 0.548835718895148 0.583118195234364 1.0 1.0 3 P50851 1 +Lymphoproliferative disorder 0.6898919295602566 0.548835718895148 0.583118195234364 1.0 1.0 3 P50851 1 +Rieger anomaly 0.4804365701935951 0.5479381930031654 0.5837343427856192 1.0 1.0 5 Q12948 1 +Bifid scrotum 0.4605954578298016 0.5470193076464984 0.5843654675061389 1.0 1.0 6 Q69YQ0,Q96EK5,P16435 3 +Abnormal heart rate variability 0.5375356762879432 0.5427187611415669 0.5873234548391479 1.0 1.0 4 P07602 1 +Hypermethioninemia 0.4787798408487937 0.5417586542634143 0.5879847774739613 1.0 1.0 5 Q6PGP7,P55263,Q9UJS0,P23526 4 +Gingival overgrowth 0.3464058053828626 0.5405953668817036 0.5887865120134124 1.0 1.0 26 P16278,P21281,P08236,Q14739,Q6DKJ4 5 +Infectious encephalitis 0.4083894699164592 0.5405674948530282 0.5888057275305163 1.0 1.0 10 Q9NZ08 1 +Conical tooth 0.4570844367290869 0.5398740398497268 0.5892839020400586 1.0 1.0 7 P21281 1 +Postaxial hand polydactyly 0.4081190970583931 0.5393155504204062 0.5896691407076706 1.0 1.0 10 Q9UBM7,Q8NCM8,Q9BW83,Q9ULC3,Q14739,Q9Y263 6 +Hypertrophic cardiomyopathy 0.3424665906747684 0.5349884609887204 0.5926578364420636 1.0 1.0 98 P10253,Q9Y3Z3,P53701,P16278,Q9Y6M9,Q86Y39,P54802,P03886,P00403,Q96IX5,P49748,Q96AX1,P00846,O00170,P15586,Q96CU9 16 +Vertebral segmentation defect 0.3463000782169269 0.5343508401048819 0.5930988240161672 1.0 1.0 27 P16435,P21281,Q9Y619,Q9UHX1,Q8TAA9,P63241,Q6DKJ4 7 +Ulnar deviation of the hand 0.5343662773904335 0.5319512314708682 0.594759773001686 1.0 1.0 4 Q14739 1 +Limited elbow extension 0.4064288998041102 0.5315045894115019 0.5950691618417276 1.0 1.0 10 Q9H6K4 1 +Areflexia 0.3215416844478027 0.5283896598302434 0.5972289128148149 1.0 1.0 78 Q96T60,P10253,Q13510,Q8TEQ6,Q9Y5P6,Q16637,Q9NR77,Q9BQT8,P50542,Q9H6K4,O00764,Q9Y6X9,Q96RR1,Q9Y223 14 +Hip contracture 0.3935588189939892 0.5280879120170485 0.5974383203222708 1.0 1.0 13 Q96AY3,Q7LGA3 2 +Leukodystrophy 0.3230908830828869 0.5275940940707757 0.597781093005801 1.0 1.0 54 Q9Y3Z3,P07602,P04350,Q9Y6M9,Q86Y39,P03886,Q96CU9 7 +Delayed myelination 0.3116410057350964 0.5247068172748329 0.5997870174379472 1.0 1.0 69 P00374,Q96T60,Q09472,Q15042,Q02252,Q96AX1,Q9Y6X9,Q7LGA3,Q96CU9 9 +Progressive hearing impairment 0.3923264953824467 0.521955391572615 0.6017013899718242 1.0 1.0 13 P00403,P03886 2 +Cutaneous syndactyly of toes 0.4731261457293198 0.5208344184684053 0.6024821241381291 1.0 1.0 5 Q09472,P27635 2 +Acute coronary syndrome 0.3761536440197964 0.5188724503585757 0.6038496905803643 1.0 1.0 17 O75844 1 +Paraparesis 0.3413627468446025 0.5127407861267079 0.6081326553230721 1.0 1.0 25 Q9H6K4,P04062 2 +Motor seizure 0.3420118312009432 0.5104479751730706 0.6097376535244976 1.0 1.0 100 Q96T60,P07602,P04062,Q96N66,Q9UBX3,Q2M389,P16278,Q9NZJ7,P27635,Q08J23,P03886,Q9NZ01,O75503,Q96F86,Q9NUQ7,P43034,P00846,Q13510 18 +Central nervous system cyst 0.3210451394423917 0.508706338681497 0.610958078694428 1.0 1.0 54 Q8NCM8,Q13363,Q9Y5P6,O14802,P15291,O43684,P21281,P07437,P23786,Q9Y487,Q9UHX1,Q9NQT5,P00846 13 +Impaired t cell function 0.3974528721323187 0.507146724421058 0.612051872723643 1.0 1.0 11 Q96DF8,P17812,Q92766 3 +Abnormality of the mitochondrion 0.3356843679072248 0.5061648311469865 0.6127409415775724 1.0 1.0 94 Q9UBX3,Q9Y6M9,Q86Y39,P03886,O43772,P00403,P23786,P49748,P00846,Q96CU9,Q9Y223,Q70HW3 12 +Adenomatous colonic polyposis 0.5264137089696362 0.5052607006570515 0.6133757413425718 1.0 1.0 4 P28340 1 +Noncompaction cardiomyopathy 0.6749502982107469 0.5045780277670838 0.6138552455478048 1.0 1.0 3 P21912,Q15233 2 +Scrotal hypoplasia 0.3655629612620379 0.5034545888090121 0.6146447000053388 1.0 1.0 19 P07437,P16435 2 +Abnormal incisor morphology 0.3652256554956112 0.5015162390260045 0.6160078520779926 1.0 1.0 19 Q09472,P21281,P49711,P42858,Q7LGA3 5 +Aplasia hypoplasia of the ribs 0.3647836420448814 0.4989783376056317 0.6177946449093472 1.0 1.0 19 Q8NCM8,Q14739,P21281,Q9UHX1,Q8TAA9,Q96HY6,Q9Y619 7 +Abnormal clavicle morphology 0.3688159741313407 0.4987486828286478 0.6179564436880647 1.0 1.0 18 P48651,Q96AY3,Q14739,Q9Y619,O75844 5 +Generalized tonic seizure 0.3756969914248462 0.4985688557145085 0.6180831503003634 1.0 1.0 16 P43034,Q96T60,P27635 3 +Abnormal left ventricle morphology 0.3417261113602155 0.498078898238305 0.6184284331381158 1.0 1.0 28 P10253,Q15233,O75880,P03886,P00403,O00170 6 +Abnormal venous morphology 0.3378949177447129 0.4967367190617019 0.6193747251007751 1.0 1.0 24 P48651,Q92766,P04062,Q6UX04,O14802,Q9Y487 6 +Numerous pigmented freckles 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Low set nipples 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Tiger tail banding 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Increased mean corpuscular hemoglobin concentration 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Concave nail 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Abnormal mean corpuscular hemoglobin concentration 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Defective dna repair after ultraviolet radiation damage 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Abnormality of dna repair 0.6721624434694128 0.4964811634155664 0.6195549739882584 1.0 1.0 3 P19447 1 +Abnormal circulating bilirubin concentration 0.3406614825885444 0.4958397865006184 0.6200074516162108 1.0 1.0 27 P43034,Q14739,P23786,P00390 4 +Cessation of head growth 0.4472829843149213 0.4954981153147675 0.6202485520583283 1.0 1.0 6 Q9NR50,Q13144,P49770,Q9Y263 4 +Abnormal epiglottis morphology 0.5233321434792038 0.4950488664001429 0.6205656268986401 1.0 1.0 4 Q8NCM8,Q13510 2 +Abnormality of the pancreas 0.3054756437589457 0.4945450433106944 0.6209213034732228 1.0 1.0 66 Q9NZ08,P11802,P09601,P03886,P00403,O43826,Q01844,P53985 8 +Neoplasm of the tracheobronchial system 0.6750579662139857 0.4939021325312556 0.6213752984414664 1.0 1.0 2 Q9UPY3 1 +Inguinal hernia 0.3232616747295683 0.4929516635008183 0.6220467414537327 1.0 1.0 83 P27635,Q96DF8,P16278,Q6UX04,P49711,P07437,P08236,Q9Y487,Q8NCH0,Q6DKJ4,Q9Y223 11 +Incisor macrodontia 0.3677764580801207 0.4929429130964765 0.6220529244936259 1.0 1.0 18 P21281,Q7LGA3,P49711 3 +Gastrointestinal stroma tumor 0.6747267307055391 0.4928793998873423 0.6220978037568838 1.0 1.0 2 P21912 1 +Blue sclerae 0.3592128126833001 0.4925818394212187 0.6223080825769316 1.0 1.0 20 Q96AY3,Q9Y4R8,Q8NCH0,O75718,P62266,Q6DKJ4 6 +Abnormal middle phalanx morphology of the hand 0.4275041476521264 0.4903425089664598 0.6238915513579237 1.0 1.0 8 Q15233,P48651,Q8IWS0 3 +Lymphedema 0.3855973799316078 0.4887468543271653 0.6250209277931966 1.0 1.0 13 P26358,P08236,Q14739 3 +Oligodontia 0.3934647276580806 0.4885560996704988 0.6251559996075926 1.0 1.0 11 P21281 1 +Bradykinesia 0.3425340669955418 0.4871878514130683 0.6261252137804663 1.0 1.0 23 Q96IX5,P35270,P42858,P04062 4 +Prominent occiput 0.3892582721813433 0.4867272847902827 0.6264516068285713 1.0 1.0 12 P37287,O15111,P21281 3 +Abnormal activity of mitochondrial respiratory chain 0.3209141077488727 0.4864335604935406 0.626659800748337 1.0 1.0 53 Q9UBX3,Q9Y6M9,P03886,Q70HW3,Q96CU9 5 +Aplasia hypoplasia involving the nose 0.3405238949953029 0.4855307891006328 0.627299877850785 1.0 1.0 29 Q96DF8,Q6UX04,O75844,P21281 4 +Lower limb muscle weakness 0.3401648826127953 0.4829721130730427 0.6291155371510389 1.0 1.0 39 Q96T60,Q9NR77,Q9Y6X9,P00846,Q9Y223 5 +Abnormality of female external genitalia 0.3414758485894168 0.4824546328170628 0.6294830189939189 1.0 1.0 33 Q08J23,Q15042,P16435,P49711,P50542,Q15392,Q6DKJ4 7 +Wide cranial sutures 0.4247647846221435 0.4792121578417327 0.6317877059421457 1.0 1.0 8 O75718,O75844 2 +Aplasia hypoplasia involving bones of the thorax 0.3405086467238918 0.4789763544039352 0.6319554503702349 1.0 1.0 31 P48651,P16435,P21281,Q9UHX1,Q8TAA9,Q14739,Q9Y619,O75844 8 +Stenosis of the external auditory canal 0.424494519909728 0.4781179603537945 0.6325662495269517 1.0 1.0 8 Q13363,P16435 2 +Increased csf lactate 0.3258378850226882 0.475678673265055 0.634303316899782 1.0 1.0 50 Q9Y6M9,Q86Y39,P03886,P00846,Q96CU9 5 +Abnormal vertebral morphology 0.3383284489440709 0.473219460048548 0.6360566155589802 1.0 1.0 100 Q96J02,Q8NCM8,Q14108,Q13045,P08236,P10619,Q8TAA9,Q14739,P16278,P04066,P16435,P63241,Q8IWS0,P54802,Q9NUQ7,O75718,Q6DKJ4,O00170,Q15436,P04062,Q96AY3,O14802,P21281,Q9UHX1,Q8NCH0,Q9Y619,P15586 27 +Tetany 0.4396151293961382 0.4716139055836758 0.6372023993777949 1.0 1.0 7 Q92766,Q15813,O00192,Q92890,P53992,P21964 6 +Corneal neovascularization 0.4396151293961322 0.4716139055836518 0.637202399377812 1.0 1.0 7 Q92766,O00192,Q92890,P53992,P18074,P21964 6 +Occipital meningocele 0.4396151293961317 0.4716139055836503 0.6372023993778131 1.0 1.0 7 Q10713,Q92766,O00192,Q92890,P53992,P21964 6 +Preaxial polydactyly 0.3819226759296785 0.4708213989848165 0.637768281856268 1.0 1.0 13 Q8NCM8,Q13363,P49454,Q9UHX1,Q9H3P2 5 +Cerebellar cyst 0.3390889860505615 0.4681979417160232 0.639643043962455 1.0 1.0 37 Q8NCM8,Q9Y5P6,O14802,P15291,O43684,P21281,P07437,P23786,Q9Y487,Q9NQT5 10 +Nuclear cataract 0.458554376657808 0.4681549317885335 0.6396737987298733 1.0 1.0 5 O76024,Q03426,P08670,Q99797 4 +Abnormal morphology of the abdominal musculature 0.4217345541343188 0.4669850444402474 0.6405105781467149 1.0 1.0 8 Q8NCH0,P42345 2 +Heart block 0.3547822814383745 0.4666575553439877 0.6407449015769462 1.0 1.0 20 P23786,P49748 2 +Vascular neoplasm 0.3392624869148637 0.4664177126814577 0.6409165353703759 1.0 1.0 35 Q15436,Q09472,P42345,P16435,P21281,Q9UHX1,P10619,Q7LGA3 8 +Multiple suture craniosynostosis 0.4394693200663233 0.465986620682678 0.641225077356816 1.0 1.0 6 Q92766,O00192,Q92890,P53992,P21964 5 +Hypertensive crisis 0.4394693200663233 0.465986620682678 0.641225077356816 1.0 1.0 6 Q92766,O00192,Q92890,P53992,P21964 5 +Abnormality of the tonsils 0.4394693200663233 0.465986620682678 0.641225077356816 1.0 1.0 6 Q92766,O00192,Q92890,P53992,P21964 5 +Tricuspid atresia 0.4394693200663233 0.465986620682678 0.641225077356816 1.0 1.0 6 Q92766,O00192,Q92890,P53992,P21964 5 +Rod cone dystrophy 0.3379085858018227 0.4659820877492444 0.6412283220059694 1.0 1.0 39 Q9BW83,P27635,Q8N2K0,Q6UX04,P03886,P50542,P00846,P38435 8 +Ectopia pupillae 0.4568735751345281 0.4622022056825456 0.6439363216667895 1.0 1.0 5 Q12948 1 +Abnormal cerebral vascular morphology 0.2989603282998035 0.4612028959015726 0.6446530442220921 1.0 1.0 63 Q9Y3Z3,O00443,P10253,P04062,P27635,P03886,P00403,P23786,P05067,P49257,O75844 11 +Abnormal blood transition element cation concentration 0.3837119115146541 0.4604863109071785 0.6451671950289144 1.0 1.0 12 P37287,Q9Y487 2 +Abnormal pulmonary thoracic imaging finding 0.3580138817143802 0.4604271082752553 0.6452096805975012 1.0 1.0 19 Q9NZ08 1 +Polycystic kidney dysplasia 0.3653691685289215 0.4602897698122323 0.645308243220498 1.0 1.0 17 Q6PGP7,Q8NCM8,Q92766,P50542,P23786 5 +Developmental glaucoma 0.338146149401929 0.4592174576644119 0.6460780152449062 1.0 1.0 23 Q9Y3Z3,P61254,P61313,P08708,P46783,P62244,P18077,Q12948 8 +Ecchymosis 0.3792574851849586 0.4579185093395683 0.6470109884946875 1.0 1.0 13 Q8NCH0,O00170,P04062 3 +Sparse or absent eyelashes 0.3311134900851545 0.4520907693993941 0.6512035931593829 1.0 1.0 24 P62304,O75844 2 +Abnormal tricuspid valve morphology 0.3816602587789559 0.4508700994821861 0.6520831748176177 1.0 1.0 12 Q92766,Q15233,Q6DKJ4,P53701 4 +Distal amyotrophy 0.3071155860003503 0.4490651929273278 0.653384628579549 1.0 1.0 57 Q96T60,Q15120,Q8N2K0,Q9NR77,Q9BQT8,Q9Y6X9,Q9Y223,Q99720,Q13510 9 +Prematurely aged appearance 0.3355759016538491 0.4485180621960428 0.6537793536291792 1.0 1.0 39 Q13126,P48651,Q96CW1,Q15042,Q13315,Q9Y487,O75844 7 +Dyspnea 0.3338631162170373 0.4480051031809927 0.6541495136365927 1.0 1.0 98 P10253,Q15165,P04062,P04350,P03886,P21281,P23786,P49748,P00846,O75844 10 +Dilatation of the ventricular cavity 0.6546369420601563 0.4468242287787804 0.6550019760523362 1.0 1.0 3 Q9Y5P6 1 +Abnormal peripheral nervous system physiology 0.3321774972581968 0.4458338660973958 0.6557172567331273 1.0 1.0 43 Q96T60,P07602,Q15120,Q9NZJ7,Q9NR77,Q9Y6X9,O43681,Q99720 8 +Relative macrocephaly 0.3362806468712042 0.4457487465464724 0.6557787483252793 1.0 1.0 33 Q96J02,Q15233,P48651,Q9Y296,O14802,Q07864,Q15392,Q6DKJ4,Q9BPU6,Q96PZ0,P42858,O75844,Q7LGA3 13 +Abnormal b cell morphology 0.4164040565328424 0.4457015666634898 0.6558128327587434 1.0 1.0 8 P17812,P50851,Q7L590 3 +Sepsis 0.365467380705278 0.4447419218062804 0.6565062699663231 1.0 1.0 16 P42892,P49711 2 +Abnormality of the humeroradial joint 0.4157883013243731 0.4432620747372879 0.6575761841440619 1.0 1.0 8 Q09472,P16435 2 +Abnormality of the sense of smell 0.3615128402188658 0.4397012309637597 0.6601535109213044 1.0 1.0 17 P42858,P04062 2 +External ophthalmoplegia 0.3670696988436716 0.4396750821125695 0.6601724523414803 1.0 1.0 15 Q13509,P03886 2 +Abnormal circulating methionine concentration 0.4309887193098753 0.4389349941104308 0.6607086394974013 1.0 1.0 7 Q6PGP7,Q9UJS0,P16930,Q99707,P55263,P23526 6 +Abnormal cranial nerve physiology 0.2975731004612569 0.4383558068288591 0.6611283770430374 1.0 1.0 60 Q9NZ08,P07602,Q9Y223,Q9Y5P6,Q9NZJ7,Q9BUF5,Q9NR77,P50542,Q13509,O00170,Q13510 11 +Biconcave vertebral bodies 0.4319276293400156 0.4380619484626534 0.661341377228811 1.0 1.0 6 Q96AY3 1 +Abnormal sweat gland morphology 0.6503719767446502 0.4350797074670913 0.6635045723106974 1.0 1.0 3 O75844 1 +Abnormal vitamin b12 level 0.4308457711442665 0.4341035215760182 0.664213268344872 1.0 1.0 6 P41440,Q96EY8,P49327,Q99707,P11586 5 +Renal tubular dysfunction 0.3344896918485556 0.4329649021382922 0.6650402681298633 1.0 1.0 36 P03886,Q9Y6M9,Q86Y39,Q96CU9 4 +Dilated fourth ventricle 0.3324181402680755 0.4292006144010677 0.6677772359092669 1.0 1.0 40 Q9UBM7,Q96KP1,Q8NCM8,Q9Y5P6,O14802,P15291,O43684,P21281,P63000,P07437,P23786,Q9Y487,Q9BPU6 13 +Infantile spasms 0.3340346436193459 0.4289919799639827 0.6679290611982815 1.0 1.0 35 Q96T60,Q9UBX3,P03886,P43034,P00846,Q13510 6 +Retinal dystrophy 0.3203201447539643 0.4284678696137889 0.6683105212829592 1.0 1.0 50 Q09472,Q9BW83,P53701,P27635,Q8N2K0,Q9Y4R8,Q6UX04,P03886,P50542,P00846,P38435 11 +Abnormal aortic arch morphology 0.3727448331795961 0.426755900949166 0.6695571296528275 1.0 1.0 13 Q09472,Q92766,Q96DF8,Q9UHX1,Q92890 5 +Hydrocele testis 0.4271578948843725 0.4246625569139383 0.6710826828983651 1.0 1.0 7 Q9UBX3 1 +Delayed fine motor development 0.4104049442770915 0.4221090624745072 0.6729454134354766 1.0 1.0 8 Q13509 1 +Abnormal pharynx morphology 0.3326330633951691 0.4220599836148004 0.6729812353327174 1.0 1.0 32 Q09472,P16278,P54802,P08236,P15586,Q13510 6 +Macrodontia 0.3470192654215274 0.4219228805803851 0.6730813086391261 1.0 1.0 20 P21281,Q7LGA3,P49711 3 +Increased susceptibility to fractures 0.3226856418264268 0.4204666234690905 0.6741446068390033 1.0 1.0 48 Q13126,P04062,Q96AY3,P16435,Q14108,O43826,Q14739 7 +Poor wound healing 0.4265357227298679 0.4184559933219201 0.6756137550623087 1.0 1.0 6 O00170,P04062 2 +Corneal erosion 0.6440906146097389 0.418037339118981 0.6759198173979017 1.0 1.0 3 P51648 1 +Neoplasm of the larynx 0.4988934719533044 0.4168887023211828 0.6767598175224692 1.0 1.0 4 P43246,P52701 2 +Muscle fiber inclusion bodies 0.3808290699331967 0.416847912538496 0.6767896545656149 1.0 1.0 10 Q9Y223 1 +Mutism 0.3666924036710421 0.4166952894481043 0.6769013003012421 1.0 1.0 14 O00443,P42858,Q13510 3 +Abnormality of the thenar eminence 0.3598625207947556 0.4158294129740356 0.6775348343261705 1.0 1.0 16 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Molar tooth sign on mri 0.6428098078197473 0.414600308617791 0.6784345222234838 1.0 1.0 3 Q96KP1,Q10713 2 +Abnormal electroretinogram 0.3310688528076831 0.4139294651037946 0.6789257641999871 1.0 1.0 31 P00846,O14773,P50897 3 +Limitation of joint mobility 0.3294093464103453 0.413403036170635 0.6793113505246553 1.0 1.0 97 O00443,Q96AY3,P16278,Q15042,P54802,P16435,P23786,Q9H6K4,P08236,Q96AX1,O75844,P15586,Q9Y223,Q7LGA3 14 +Decreased circulating iga level 0.4240264516194426 0.413110568300093 0.6795256068046212 1.0 1.0 7 Q96J02,Q13315,P42345 3 +Erythroid hypoplasia 0.3564691534903347 0.4130878135567092 0.6795422775731901 1.0 1.0 17 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Abnormality of subcutaneous fat tissue 0.3658689184447416 0.4127021382410492 0.6798248580478328 1.0 1.0 14 O75844 1 +Generalized joint laxity 0.3730843508085497 0.411240433055064 0.680896242929089 1.0 1.0 12 Q8NCH0,Q9Y487,Q9UHX1 3 +Aplasia hypoplasia of the humerus 0.4073748972118534 0.4103449852245993 0.6815528969379347 1.0 1.0 8 O00116,P50542,O14802 3 +Abnormality of prothrombin 0.3609603471856791 0.4089982364080631 0.6825409553849704 1.0 1.0 15 P49257,Q9Y223,P38435 3 +Abnormal cervical spine morphology 0.4237825482164433 0.4085656440360006 0.6828584475637061 1.0 1.0 6 Q8NCH0,P04066 2 +Abnormal odontoid tissue morphology 0.3308325188340265 0.4081063916160642 0.6831955677429371 1.0 1.0 37 Q9UBM7,O00443,P51648,Q09472,P48651,Q92766,P53701,Q96AY3,P16278,P19447,Q92890 11 +Hyperconvex nail 0.4065499095004559 0.407160230946221 0.6838903083536623 1.0 1.0 8 P42892,Q9Y619,P48651 3 +Dyscalculia 0.3743970509925194 0.4021931570965912 0.6875418778655926 1.0 1.0 11 Q96T60,P22626,P46821,Q06787 4 +Reduced visual acuity 0.3378333720058585 0.401212332824518 0.6882638015103961 1.0 1.0 107 Q9NZ08,P07602,P50897,O43681,P53701,Q9NZJ7,P16278,Q9Y6M9,Q9Y5P6,Q86Y39,P03886,Q9H6K4,P00846,Q13509,P68371,O00170,Q96CU9 17 +Elongated superior cerebellar peduncle 0.6425968863862295 0.3983194045675503 0.6903947585780421 1.0 1.0 2 Q10713 1 +Abnormal superior cerebellar peduncle morphology 0.6425968863862295 0.3983194045675503 0.6903947585780421 1.0 1.0 2 Q10713 1 +Abnormality of hair texture 0.310997436905234 0.3981222396994087 0.6905400816007159 1.0 1.0 53 Q15436,Q6PGP7,P42345,Q08J23,Q15022,P54802,P19447,Q9Y487,Q96AX1,P46778,P15586,Q9BPU6,P62266,Q9Y5P4,O75844 15 +Hand polydactyly 0.3281964499542419 0.397967512404125 0.6906541334276093 1.0 1.0 30 Q8NCM8,Q13363,Q9BW83,Q92766,Q92890,Q13045,Q9UHX1,Q9H3P2,Q14739,Q9Y263 10 +Cns hypomyelination 0.3295872974934976 0.397583259423628 0.6909374024775201 1.0 1.0 35 Q99720 1 +Waddling gait 0.3282599680310169 0.3973957803287076 0.6910756266813642 1.0 1.0 23 Q9Y5P6,P22626,Q9Y281,Q9NUQ7,P07196,Q9Y6X9,Q06210,Q13510,P50402 9 +Abnormality of neuronal migration 0.3634717319130137 0.3954489745922843 0.6925115715953292 1.0 1.0 136 Q9BVA1,Q9Y5P6,Q86XL3,Q15042,Q9NZ01,Q9Y487,Q13885,Q2M389,P07437,Q6ZXV5,P43034,Q2TAA5,Q08J23,P23786,Q9NUQ7,Q96F86,Q13509,Q96T60,Q96N66,Q9NPF4,P21281,P50542,Q15392 23 +Preaxial hand polydactyly 0.387185508447453 0.3930516795761812 0.6942813118906528 1.0 1.0 9 Q8NCM8,Q13363,Q9UHX1 3 +Large beaked nose 0.4193730580747259 0.392901313824112 0.6943923711643833 1.0 1.0 6 Q9Y3Z3 1 +Short foot 0.3266693211986144 0.3920278399237371 0.6950376436256531 1.0 1.0 29 Q13509,Q9Y5P4 2 +Abnormality of retinal pigmentation 0.2950333694269724 0.3888221626502941 0.6974077049485254 1.0 1.0 66 Q9BW83,Q9Y5P6,Q15042,P03886,P00403,P50542,Q96AX1,Q9Y6X9,P00846,Q96CU9 10 +Abnormality of central nervous system electrophysiology 0.3636383046063384 0.3886713830405994 0.6975192541600013 1.0 1.0 137 Q9UBX3,Q9Y5P6,Q9NZ01,Q14108,O75503,Q13885,Q8NC96,Q09472,P27635,Q2M389,P03886,P00403,P43034,Q2TAA5,Q8IWS0,P49366,P50897,Q08J23,Q96F86,Q9NUQ7,Q9Y6X9,Q96T60,P07602,Q96N66,Q9NZJ7,Q9NPF4,P21281,P50542 28 +Abnormality of iron homeostasis 0.4173513893930431 0.3857938341175291 0.6996493621349682 1.0 1.0 6 P37287 1 +Reticulocytopenia 0.3504108577434093 0.3816254413043254 0.7027392105465156 1.0 1.0 17 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Abnormality of the amniotic fluid 0.3097832271848938 0.3784666906092442 0.7050839338139454 1.0 1.0 81 P49366,Q09472,P04062,Q14739,P27635,Q9Y5P6,Q9NPF4,P21281,P16435,P23786,Q70HW3,Q9Y5P4,O75844,Q7LGA3 14 +Premature loss of teeth 0.368230380285773 0.375262597991824 0.7074651794705344 1.0 1.0 11 Q15436,O14802,O75844 3 +Abnormal circulating sulfur amino acid concentration 0.3821381142098277 0.3728861279670794 0.7092331969208341 1.0 1.0 9 P41440,Q6PGP7,Q9UJS0,P16930,Q99707,Q9Y4U1,P55263,P23526 8 +Abnormal circulating aspartate family amino acid concentration 0.3821381142098278 0.3728861279670794 0.7092331969208341 1.0 1.0 9 Q6PGP7,Q9UJS0,P16930,Q4G0N4,Q99707,Q9Y4U1,P55263,P23526 8 +Partial agenesis of the corpus callosum 0.3533211133162882 0.3713934309892025 0.7103445175850738 1.0 1.0 15 Q13509 1 +Aplasia hypoplasia of the thymus 0.3484060517948946 0.3713425293552738 0.7103824249941346 1.0 1.0 17 Q6PGP7,Q92766,Q7L590,Q13315,P50542 5 +Abnormality of the thymus 0.3484060517948946 0.3713425293552738 0.7103824249941346 1.0 1.0 17 Q6PGP7,Q92766,Q7L590,Q13315,P50542 5 +Abdominal wall muscle weakness 0.6326598211328348 0.3710762502235477 0.710580739773929 1.0 1.0 2 P46976 1 +Abnormality of the 5th toe 0.4130349192598228 0.3707795679494012 0.7108017207616664 1.0 1.0 6 Q14739,Q8NCM8,Q9Y263 3 +Postaxial foot polydactyly 0.4130349192598228 0.3707795679494012 0.7108017207616664 1.0 1.0 6 Q14739,Q8NCM8,Q9Y263 3 +Ichthyosis 0.3239618761519788 0.3698243761577917 0.7115133513844192 1.0 1.0 30 Q15800,O95470,Q6UX04,P04062 4 +Ophthalmoparesis 0.2952047813703334 0.3692294588125554 0.7119566998405662 1.0 1.0 68 Q9BPX6,P04062,P03886,P00846,Q13509,Q96CU9 6 +Abnormality of chorioretinal pigmentation 0.482898815301991 0.3687424570771441 0.7123196991771925 1.0 1.0 4 Q96AX1 1 +Hypoplastic labia minora 0.4292535451233938 0.3685206786739217 0.7124850290535714 1.0 1.0 5 Q15042 1 +Clitoral hypoplasia 0.4292535451233938 0.3685206786739217 0.7124850290535714 1.0 1.0 5 Q15042 1 +Blepharophimosis 0.3147794624234619 0.3682717658289099 0.7126706030253025 1.0 1.0 49 Q8IWS0,Q09472,Q86UE8,Q96DF8,P07437,P42858,O75844,Q7LGA3 8 +Premature skin wrinkling 0.3444097810300594 0.3664097953966825 0.7140593115509333 1.0 1.0 18 Q9Y487,O75844,Q96CW1 3 +Pure red cell aplasia 0.3441729339116393 0.3651710278746631 0.7149837435647655 1.0 1.0 18 P00491,P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 10 +Generalized hyperreflexia 0.4812290367508595 0.3638662013903837 0.7159579244734968 1.0 1.0 4 P19447 1 +Small earlobe 0.3798147127182502 0.3637173457624321 0.7160690892213215 1.0 1.0 9 P10586,Q92766 2 +Diffuse mesangial sclerosis 0.351620540772216 0.3631438714872473 0.7164974136038227 1.0 1.0 15 Q9NPF4 1 +Absent or minimally ossified vertebral bodies 0.6229942643746449 0.3631409602592054 0.716499588209695 1.0 1.0 3 Q14739 1 +Abnormally ossified vertebrae 0.6229942643746449 0.3631409602592054 0.716499588209695 1.0 1.0 3 Q14739 1 +Recurrent respiratory infections 0.3394034136106283 0.3613331187057677 0.7178504386020752 1.0 1.0 113 Q96J02,Q13363,P02786,P09601,P49711,Q16637,Q13315,P08236,Q9Y487,Q96AX1,Q09472,P16278,P04066,P54802,Q6DKJ4,Q13510,Q9UJW0,P10253,P07602,P04062,Q9NZJ7,O14802,Q9NPL8,P50542,P78318,P15586 26 +Cholestasis 0.2975792634308135 0.3611574324248358 0.717981761542211 1.0 1.0 71 P00374,Q9Y3Z3,O15118,P49711,P50542,P49748 6 +Abnormality of the hallux 0.304609517337104 0.3605637573339401 0.7184255866727882 1.0 1.0 54 Q96J02,Q13363,Q9Y296,Q6UX04,P49711,Q93009,Q9BPU6,P42858,Q09472,Q15056,Q15427,Q6DKJ4,Q15233,P04062,P21281,Q9UHX1,Q9H3P2,Q96PZ0,Q9Y223,Q7LGA3 20 +Biparietal narrowing 0.4087591240875815 0.3583665376631523 0.7200690300338946 1.0 1.0 7 Q9UBM7,Q10713,Q13620,Q12756,P36405,Q02750 6 +Macular purpura 0.3505753824428164 0.3580966837253991 0.7202709607285158 1.0 1.0 15 Q8NCH0,O00170,P04062,P38435 4 +Retinal detachment 0.3578438165667377 0.3576199786102693 0.7206277250639441 1.0 1.0 13 Q8NCH0,Q9Y5P6 2 +Abnormal serum iron concentration 0.4258177058799459 0.3574597905387221 0.7207476228784226 1.0 1.0 5 P37287 1 +Steppage gait 0.3391600697771801 0.3566719779529672 0.7213373859178758 1.0 1.0 19 Q9NR77 1 +Wormian bones 0.3480210899508655 0.3562755300204318 0.7216342328386791 1.0 1.0 16 Q96AY3,O75844,Q9Y487 3 +Oculogyric crisis 0.3930533254001367 0.3562275852559569 0.721670135113871 1.0 1.0 8 P35270 1 +Abnormality of the nasal tip 0.3225466583572405 0.3556053554631757 0.7221361324103739 1.0 1.0 96 Q86UE8,Q96DF8,P16278,P42892,Q15042,P21281,P49711,P16435,P23786,P10586,Q02252,Q6DKJ4,O75844,Q7LGA3 14 +Increased serum lactate 0.329272158205607 0.3548183570282218 0.7227256751112983 1.0 1.0 103 Q9BWD1,O14949,O75880,Q9UBX3,Q9Y6M9,Q86Y39,P03886,P00403,P00846,Q96CU9,Q70HW3 11 +Neoplasm of fatty tissue 0.3773825551742879 0.354198587868306 0.7231900618022553 1.0 1.0 9 Q8TAA9 1 +Aplasia hypoplasia of the phalanges of the hand 0.3155536351969517 0.3513854484311094 0.7252991977322358 1.0 1.0 47 O95630,P48651,P42345,Q6UX04,P16435,P21281,O15111,O75844,Q14739,Q6DKJ4,Q8IWS0,P38435 12 +Abnormal glomerular mesangium morphology 0.3468009492623016 0.3502668942597255 0.7261384080168931 1.0 1.0 16 Q9NPF4 1 +Anemia of inadequate production 0.2885661401653475 0.3498137832481027 0.7264784542794516 1.0 1.0 60 P00374,P22830,P61313,Q9UBX3 4 +Congenital contracture 0.3202732973384593 0.3486778485981949 0.7273311760794896 1.0 1.0 42 P04062,Q15392,Q9Y6X9,Q8NCH0,O75844 5 +Cavernous hemangioma 0.475638051044072 0.3477549143080156 0.7280242518515516 1.0 1.0 4 P21912,P50570,Q02750 3 +Loss of ability to walk 0.3555706702225286 0.3473636687147586 0.72831812417227 1.0 1.0 13 Q9Y5P6,P00846 2 +Childhood onset 0.3220798804951787 0.3464900314768845 0.7289744745308517 1.0 1.0 34 Q9NR77,Q5JRX3,Q9NUQ7,Q14566 4 +Decreased circulating antibody level 0.3221388019745883 0.3464285647629542 0.7290206610247727 1.0 1.0 37 Q96J02,Q9UJW0,Q6PGP7,P42345,P02786,P50851,P09601,Q13315,Q96AX1,P17812 10 +High anterior hairline 0.3293228129649344 0.3461812625415284 0.729206495480736 1.0 1.0 21 Q7LGA3,P21281 2 +Stage 5 chronic kidney disease 0.3179074236644755 0.3461108767029667 0.7292593896008939 1.0 1.0 27 O43826,P23786,Q9NPF4 3 +Developmental cataract 0.3083379985949159 0.3425140939136304 0.7319640393055944 1.0 1.0 51 O00443,P61313,P03886,P00403,Q15800,P50542 6 +Gastrointestinal carcinoma 0.3189427933685069 0.3415817663262982 0.7326656610713522 1.0 1.0 29 P63167,Q09472,P28340,P61254,P61313,P08708,P43246,Q07864,P52701,P62244,P18077 11 +Polyhydramnios 0.3128815121050806 0.340924333901924 0.733160545269216 1.0 1.0 48 Q09472,P04062,P27635,P21281,Q14739,O75844,Q70HW3 7 +Fasciculations 0.3211230130971448 0.3387893028897583 0.7347684602923263 1.0 1.0 36 P07602,Q9NQT5,Q9NZJ7,P22626,P07737,Q16637,Q9BQT8,Q9Y6X9,Q13510 9 +Dry skin 0.3166363499514015 0.3380653400837733 0.7353139490087197 1.0 1.0 27 Q9Y3Z3,P51648,Q6PGP7,Q9H4L7,Q08J23,P11802,P04066,P04080,P19447,Q2TAA5 10 +Abnormality of mouth shape 0.2908508166135801 0.3369364049421731 0.7361648410807666 1.0 1.0 67 P37287,Q15233,Q05639,P42345,P04062,Q96DF8,P04350,Q9Y4R8,Q86XL3,O14802,P21281,Q13045,P62266,Q6DKJ4 14 +Abnormal echocardiogram 0.471518375146615 0.3361009089615886 0.7367947730042339 1.0 1.0 4 P49748 1 +Abnormality of the anus 0.3177106245908883 0.3353614397274806 0.7373524520410617 1.0 1.0 43 Q8NCM8,P48651,P16615,Q08J23,Q92766,P53701,Q15022,Q69YQ0,P16435,P49748,Q8TAA9,P29372,Q6DKJ4,Q12948 14 +Aplasia hypoplasia of the 5th finger 0.3451354314241441 0.3321176741489144 0.7398004048385651 1.0 1.0 15 P21281 1 +Abnormal large intestine morphology 0.2956123546778744 0.3315567963404095 0.7402239472829719 1.0 1.0 72 P08183,P63167,P50851,Q07864,Q8TAA9,Q09472,P43246,O43826,Q15056,P62244,O75844,Q6PGP7,Q08J23,P61313,P52701,P49748,P18077,Q9UPY3,P53701,P28340,P61254,O43684,P08708 23 +Neoplasm of the stomach 0.3373663570539135 0.3300002645501368 0.7413997622242603 1.0 1.0 18 P63167,Q09472,P11802,O43684,P43246,P52701 6 +Non hodgkin lymphoma 0.371026374038865 0.3297179052828999 0.7416131231873602 1.0 1.0 9 Q13315,P52701 2 +Decreased circulating igg level 0.3709650932470853 0.3294847417828745 0.7417893250092638 1.0 1.0 9 P50851,Q13315,Q96AX1 3 +Aplasia hypoplasia involving the pelvis 0.347899085864931 0.3280733063113736 0.7428562364829681 1.0 1.0 14 Q9H3P2,O00443,P50542,Q13363 4 +Contractures of the large joints 0.6082312192277228 0.3270133023235479 0.7436578240713523 1.0 1.0 3 P50542 1 +Hypogonadotropic hypogonadism 0.3210417181803355 0.3246414622118785 0.7454524431171046 1.0 1.0 22 P00403,Q15042,P03886 3 +Broad nasal tip 0.3043743519145949 0.3244021969358097 0.7456335566909693 1.0 1.0 52 Q86UE8,P16278,Q15042,P49711,P21281,P10586,Q6DKJ4,Q7LGA3 8 +Abnormality of the upper arm 0.3362637659273603 0.3243837906940963 0.7456474900106467 1.0 1.0 18 P48651,O00116,O14802,P16435,P50542,Q9Y6X9 6 +Absent fingernail 0.3686748977687732 0.3208110423054172 0.7483535908134908 1.0 1.0 9 P21281 1 +Abnormal labia majora morphology 0.3525649579706146 0.3206074362578969 0.7485079015632581 1.0 1.0 12 P49711 1 +Hypoplastic labia majora 0.3525649579706146 0.3206074362578969 0.7485079015632581 1.0 1.0 12 P49711 1 +Functional motor deficit 0.3503441829737559 0.3185543176654197 0.7500644991777325 1.0 1.0 130 Q9Y2R0,Q9Y5P6,P00846,Q99720,P42858,Q8NC96,Q9Y3Z3,Q15120,P27635,P03886,Q9NR77,P00403,Q8TD30,O43681,Q9H845,Q9H2D1,P23786,Q9Y6X9,O00170,Q13510,Q9BPX6,P07602,Q05639,P04062,P53701,Q9NZJ7,O14773,Q96RR1 28 +Preaxial foot polydactyly 0.4651608825912898 0.318489022936046 0.7501140199359186 1.0 1.0 4 Q13363 1 +Irregular menstruation 0.3966854183536004 0.3170883640897506 0.7511765537830397 1.0 1.0 7 O43826 1 +Hypoplastic pubic rami 0.4125721776200389 0.3161781468834047 0.751867293838089 1.0 1.0 5 Q13363 1 +Rib segmentation abnormalities 0.4125721776200389 0.3161781468834047 0.751867293838089 1.0 1.0 5 Q13363 1 +Aplasia hypoplasia of the pubic bone 0.4125721776200389 0.3161781468834047 0.751867293838089 1.0 1.0 5 Q13363 1 +Abnormality of abdominal situs 0.4125721776200389 0.3161781468834047 0.751867293838089 1.0 1.0 5 Q13363 1 +Underdeveloped nasal alae 0.3094827062532808 0.3155606558174763 0.7523360048944001 1.0 1.0 24 Q96DF8,P21281,Q6UX04,Q08J23 4 +Asthma 0.3238151816398258 0.3155168320317465 0.7523692731288403 1.0 1.0 21 Q09472,P42345,Q92766,Q08J23,P50851,P50542,Q92890 7 +Abnormality of the nasal dorsum 0.3109705813067064 0.3154481702243376 0.7524213977365766 1.0 1.0 47 Q96J02,Q9Y3Z3,Q13363,Q09472,P27635,P28340,P16278,O14802,O43684,O75844,Q12948 11 +Red eye 0.3339650857224018 0.3127501069259306 0.7544705239363756 1.0 1.0 18 Q9NZ08,P28070,P02786,P50851,P19447,Q96AX1,Q14739 7 +Frontotemporal dementia 0.3556281581004569 0.3121666998323911 0.7549138381143157 1.0 1.0 10 O96008,P22626,P05067 3 +Arnold chiari malformation 0.3305148896755912 0.3111862393017958 0.755659043518589 1.0 1.0 19 P16435,Q09472,Q6UX04,Q8TAA9 4 +Abnormal proximal phalanx morphology of the hand 0.3950327837619147 0.3106757775074768 0.756047113383117 1.0 1.0 6 Q09472 1 +Abnormal thyroid hormone level 0.6081483935077944 0.3083383184475564 0.7578249115304088 1.0 1.0 2 O14654 1 +Tapered finger 0.3166498240106997 0.3082389535475851 0.7579005138252479 1.0 1.0 36 Q9H4L7,Q8WWQ0,P27635,Q9Y4R8,P42892,P46821,P23786,Q8NCH0,Q9BPU6,O00170,Q8IWS0 11 +Ridged nail 0.4098027991064078 0.3078311654124484 0.7582108057679795 1.0 1.0 5 P19447,P16615 2 +Abnormal corneal epithelium morphology 0.3393312629705606 0.30496397115833 0.7603935928578802 1.0 1.0 15 Q9NZ08,O75844 2 +Hyporeflexia 0.3316506364385598 0.304627240190704 0.7606500708238655 1.0 1.0 111 Q16637,Q13045,Q96AX1,P00846,Q99720,Q8NC96,Q15120,P03886,Q9NR77,O43681,P54802,Q9Y6X9,Q96T60,P07602,Q05639,P04062,Q9NZJ7,P21281,P50542,Q96RR1 20 +Intellectual disability moderate 0.2954360212862014 0.2994287233776853 0.7646129488271121 1.0 1.0 75 Q05639,Q08J23,Q2M389,Q12955,Q96N66,Q6UX04,Q9NZ01,Q96F86,Q9NUQ7,Q13509 10 +Diplopia 0.3246233589395088 0.2987248401012065 0.7651500023232016 1.0 1.0 20 P04062 1 +Long fingers 0.3002190211419379 0.2955704878079698 0.7675581144288675 1.0 1.0 80 Q13363,Q15334,Q9BPU6,P27635,P46821,P16435,P07437,Q8IWS0,Q8WWQ0,Q9Y4R8,P23786,Q8NCH0,O00170,Q9H4L7,Q92766,P42892,O14802,Q9NPF4,Q9UHX1,Q9H3P2,Q92890,Q9Y263 22 +Neoplasm of the large intestine 0.3140134320184475 0.295310941698764 0.7677563587883256 1.0 1.0 40 P63167,Q9UPY3,Q09472,P28340,P61254,P61313,O43684,P08708,P43246,P21912,Q07864,P52701,P62244,P18077 14 +Facial hypertrichosis 0.2827133976633355 0.29382141964451 0.7688943666512191 1.0 1.0 60 Q08J23,Q15042,P54802,O00170,P49711,P21281,Q96AX1,P15586,P62266,Q9Y5P4,Q9Y223 11 +Hyperuricemia 0.3610186230015208 0.2923976649949314 0.7699825933284228 1.0 1.0 9 O43826 1 +Hypopigmentation of the fundus 0.5928870568635619 0.2916015695881964 0.770591275211236 1.0 1.0 3 P38435 1 +Abnormality of fundus pigmentation 0.5928870568635619 0.2916015695881964 0.770591275211236 1.0 1.0 3 P38435 1 +Esophagitis 0.3881884538818836 0.2892048976201238 0.772424584162579 1.0 1.0 7 O43175,Q7Z392,Q9NQX3,P41252,P62913,O95394 6 +Hypomimic face 0.347540136166801 0.2891105238311102 0.7724968004733992 1.0 1.0 11 P35270,Q96RR1,P04062 3 +Abnormality of t cell physiology 0.3381467610924508 0.2843854333315647 0.7761150208854106 1.0 1.0 14 Q96DF8,P17812,Q92766 3 +Acanthosis nigricans 0.3586534777295727 0.2838079878309207 0.7765575327297087 1.0 1.0 9 O00170,P28070 2 +Optic disc hypoplasia 0.5889685589680543 0.2829216223773517 0.7772369192074109 1.0 1.0 3 O14802 1 +Abnormal bleeding 0.3188799947720186 0.2829044833362085 0.7772500577188057 1.0 1.0 100 Q13126,Q9NZ08,P04062,P49711,Q14108,P23786,O43826,P05067,Q9Y487,Q6ZXV5,Q8NCH0,Q14739,Q4KMQ2,O75844 14 +Tremor 0.3691630862700171 0.2827202889124446 0.7773912622018018 1.0 1.0 157 Q16637,Q14108,O75503,Q13315,P00846,Q99720,P42858,Q8NC96,Q9Y3Z3,Q15120,P27635,Q96CW1,P04350,Q8N2K0,P03886,Q9NR77,O43681,P35270,Q5JRX3,Q9H6K4,Q9Y6X9,Q13510,Q9BPX6,Q96T60,P07602,Q15233,Q05639,P04062,Q9NZJ7,O14773,Q96RR1 31 +Insulin resistance 0.3373053053054674 0.2806976259251022 0.7789423298139231 1.0 1.0 14 O75844 1 +Abnormal facial expression 0.3116350753831599 0.2794466901356536 0.779902044043081 1.0 1.0 33 Q09472,P04062,Q9Y5P6,P35270,Q9NR77,Q9Y5P4 6 +Abnormality of mouth size 0.3380963969273052 0.2784070751042304 0.7806998889803882 1.0 1.0 121 P37287,Q9Y296,Q15042,P49711,Q9Y487,P42858,Q09472,P27635,Q96CW1,P16278,P49454,P16435,P07437,P43034,O75844,P48651,Q08J23,Q6DKJ4,Q15436,Q15233,Q86UE8,P04062,P28340,Q9NPF4,P21281,Q15392,Q8NCH0,P15586,Q7LGA3 29 +Lower limb undergrowth 0.5868434199670806 0.2782773696956408 0.7807994466670434 1.0 1.0 3 O15111 1 +Tetraplegia 0.3421691711218045 0.2772826639103733 0.7815630700708447 1.0 1.0 12 P43034,Q96T60 2 +Ulnar deviation of finger 0.3843631008691237 0.2771207659461658 0.7816873770988004 1.0 1.0 6 Q15042 1 +Tetraparesis 0.3118727849033506 0.2762189404757171 0.7823799105361124 1.0 1.0 36 P07602,Q9UBX3,Q9Y296,Q9NZJ7,P43034,P00846 6 +Bilateral tonic clonic seizure 0.296077134217895 0.2758035098579904 0.7826989877610213 1.0 1.0 78 Q96T60,P07602,P04062,Q14739,P27635,Q9NZJ7,P03886,P21281,P00403,P50542,P49748,P00846,Q9Y5P4,Q13510 14 +Dystonia 0.3684081178113976 0.2755514491734663 0.7828926042765483 1.0 1.0 157 Q9NZ01,P00846,Q99720,P42858,Q96CU9,Q9Y3Z3,Q2M389,P04350,P16278,O15118,P03886,Q9NUQ7,O14949,Q13509,Q9BPX6,Q96T60,P07602,P04062,Q96N66,Q02252 20 +Abnormal fingertip morphology 0.3105510783727609 0.2755094590717277 0.782924859630689 1.0 1.0 32 Q09472,Q9Y296,P50851,P49711,Q9BPU6,P62266,P42858,O75844,Q7LGA3 9 +Thickened skin 0.3072246658430425 0.2752549812068302 0.7831203487688538 1.0 1.0 89 P28070,P04062,P28340,P16278,P04066,Q6UX04,Q15800,O95470,P07437,P50542,Q96AX1,Q14739,O00170,O75844 14 +Curly hair 0.3414544052865911 0.2743747335328236 0.7837966579433451 1.0 1.0 12 Q9BPU6,Q9Y5P4,P42345 3 +Autoamputation of digits 0.5935740311361486 0.2742251419648614 0.7839116079281052 1.0 1.0 2 P48643 1 +Acral ulceration 0.5935740311361486 0.2742251419648614 0.7839116079281052 1.0 1.0 2 P48643 1 +Flared metaphysis 0.3830661981395012 0.2728893551424378 0.7849382694455023 1.0 1.0 7 Q14739,P48651 2 +Arterial thrombosis 0.3829039350531035 0.2726593891815846 0.7851150549251147 1.0 1.0 6 Q9NZ08 1 +Abnormal patella morphology 0.3034789938826261 0.2715505967792407 0.7859675903927776 1.0 1.0 25 Q09472,Q92766,Q96AY3,P46821,Q01968,Q15056,Q6ZXV5,Q92890,Q9Y619 9 +Mildly elevated creatine kinase 0.3154952404257345 0.270466491782028 0.7868013922765047 1.0 1.0 21 Q9BPX6 1 +Abnormal auditory evoked potentials 0.3816552140735853 0.2684623871252725 0.7883434232413138 1.0 1.0 7 P07602 1 +Tongue atrophy 0.4451417372182484 0.266135220614617 0.7901350706743553 1.0 1.0 4 Q9NQT5,Q9Y6X9 2 +Abnormality of the autonomic nervous system 0.2871828846547198 0.2657871072547281 0.7904031731142367 1.0 1.0 57 P07602,Q09472,Q92766,P04062,Q6PJG6,Q9NZJ7,P42892,O14802,Q92890,Q96EK5,O43681,Q13509,O15269,Q96RR1,P06280 15 +Abnormal circulating igg level 0.3415900266482693 0.2656666348744846 0.7904959617134417 1.0 1.0 11 P50851,Q13315,Q96AX1 3 +Abnormality of thyroid physiology 0.290840435075187 0.2656422031556092 0.7905147795421155 1.0 1.0 74 Q96J02,O00443,P50851,Q13045,Q9Y3Z3,P27635,P04066,P03886,P00403,O43826,Q6PGP7,Q8WWQ0,O00170,Q92766,O14802,O43684,P21281,O95470,Q96RR1,Q9Y263,Q9Y223 21 +Abnormal choroid plexus morphology 0.3948938992042433 0.2646876621849173 0.7912500827613136 1.0 1.0 5 P53634,O96017,O43175,P07954 4 +Hepatic encephalopathy 0.4444812727875248 0.2644915500841405 0.7914011751136141 1.0 1.0 4 P09622,Q9UJS0,Q6NUQ1 3 +Exercise induced muscle fatigue 0.5795113392714357 0.262599332197134 0.7928594148306112 1.0 1.0 3 P53985 1 +Increased muscle fatiguability 0.5795113392714357 0.262599332197134 0.7928594148306112 1.0 1.0 3 P53985 1 +Hydrocephalus 0.2826870164008359 0.2584779322622234 0.7960380779124623 1.0 1.0 67 Q9UBM7,Q13363,Q9Y5P6,P08236,Q8TAA9,Q96AX1,P49454,P15291,P16435,P48651,Q08J23,P23786,Q13509,Q92766,P53701,P04062,O14802,P19447,Q15392,Q92890 20 +Retinal coloboma 0.3508988766301315 0.2562951749819866 0.797722922670868 1.0 1.0 9 Q92620,Q15042,Q9UHX1 3 +Natal tooth 0.3496279470762823 0.2518836931948471 0.8011309642445492 1.0 1.0 9 Q09472,O14802,O75844 3 +Low set posteriorly rotated ears 0.2861101334649313 0.2507766848269457 0.8019867684853419 1.0 1.0 71 Q96J02,Q9Y263,Q13363,Q9BW83,P04062,Q08J23,Q15042,O43684,P16435,P49711,P07437,P50542,Q15392,Q8NCH0,Q6DKJ4 15 +Hepatocellular adenoma 0.5730574294638148 0.2492483267495117 0.8031686993613578 1.0 1.0 3 O43826 1 +Large foramen magnum 0.5729256678305946 0.2489801855280073 0.8033761085245088 1.0 1.0 3 Q09472 1 +Alkalosis 0.4368747534559048 0.2459608208082303 0.8057125614075988 1.0 1.0 4 O00170 1 +Abnormal cerebral artery morphology 0.3259804485476995 0.2449247576658909 0.806514691570914 1.0 1.0 15 Q9Y3Z3,P10253 2 +Gait imbalance 0.3141657148106273 0.2447779610196825 0.8066283594462886 1.0 1.0 20 Q9NR77 1 +Somatic sensory dysfunction 0.3108999235237773 0.2446458128182259 0.8067306882018475 1.0 1.0 96 Q9NZ08,Q96T60,P07602,Q8IV08,O14773,P54802,Q9NR77,P05067,Q9H6K4,Q8NCH0,P00846,Q9Y6X9 12 +Nephrocalcinosis 0.3020839465091094 0.243670605923347 0.8074859403336081 1.0 1.0 23 O00443,P21281 2 +Abnormality of the clitoris 0.3217739422133996 0.2417599212871982 0.8089661959411858 1.0 1.0 17 P50542,Q15042,P53701,P16435 4 +Abnormal choroid morphology 0.2969580736894895 0.2415897549001579 0.8090980613784837 1.0 1.0 24 P50542,Q09472,P53701,Q96AX1 4 +Abnormal chorioretinal morphology 0.2969580736894895 0.2415897549001579 0.8090980613784837 1.0 1.0 24 P50542,Q09472,P53701,Q96AX1 4 +Middle age onset 0.3370253050004475 0.2414371400994795 0.8092163303414606 1.0 1.0 10 P07602 1 +Anonychia 0.3307045928381633 0.2409999558369875 0.8095551507522885 1.0 1.0 13 Q96T60,P21281 2 +Polysplenia 0.5673243668047327 0.2377466529105362 0.8120775971101097 1.0 1.0 3 Q9ULC3 1 +Abnormal circulating androgen level 0.3356357428445254 0.2364068770749848 0.8131169602848121 1.0 1.0 10 O14802,P16435 2 +Epileptic encephalopathy 0.2974485963299655 0.236309464654522 0.8131925431628977 1.0 1.0 25 Q8NC96,P37287,Q05639,P43034,Q96RR1 5 +Inappropriate crying 0.3575481232170737 0.2343395009583413 0.8147214221867911 1.0 1.0 8 P07602 1 +Hoarse voice 0.2980704087757449 0.2323439238179581 0.8162708994352987 1.0 1.0 26 Q9Y3Z3,Q69YQ0,Q15022,Q13045,Q96HY6,Q9Y223,O00170,Q13510 8 +Severe global developmental delay 0.2788149360223147 0.2321881601226701 0.8163918733539828 1.0 1.0 66 P03886,P00846,Q13509,Q13885,Q7LGA3 5 +Hyperhomocystinemia 0.430560159098436 0.2311450823576799 0.8172020926152292 1.0 1.0 4 P41440,Q99707,P23526 3 +Increased circulating prolactin concentration 0.3823635740866498 0.2308882734990492 0.8174016010189706 1.0 1.0 5 O00170 1 +Aplasia hypoplasia affecting the fundus 0.2963899792564846 0.2302326972408622 0.8179109554966866 1.0 1.0 25 Q96KP1,Q8WWQ0,Q9Y5P6,P49454,O14802,Q15058,Q9UHX1,P07196,Q13509,Q12948 10 +Myelomeningocele 0.5624828352983855 0.2282990382621689 0.8194137721747496 1.0 1.0 3 Q8TAA9 1 +Epistaxis 0.3240833952538315 0.2245918511086797 0.8222968048252597 1.0 1.0 14 O43826,P49257,P04062 3 +Focal impaired awareness seizure 0.3100272488784698 0.224158427145533 0.8226340306864235 1.0 1.0 20 P43034,Q05639,P21281,Q96CW1 4 +Absent toenail 0.3661651676020104 0.221859154140154 0.8244235283865757 1.0 1.0 7 P21281 1 +Spastic tetraplegia 0.3033339574432313 0.2205507557756424 0.8254422479718251 1.0 1.0 39 Q9Y3Z3,P16278,P04066,Q86XL3,Q13509 5 +Acne 0.318535992021044 0.2189392215168273 0.8266973932123141 1.0 1.0 16 Q9NZ08,Q92542,O00170,Q92766 4 +Short attention span 0.3368742412924459 0.2169389984427868 0.8282558848772839 1.0 1.0 127 Q9BVA1,Q9Y296,Q9NZ01,Q13045,P42858,Q8NC96,Q09472,Q2M389,P03886,P00403,O43681,Q08J23,Q96F86,Q9NUQ7,Q13509,Q96T60,P07602,Q86UE8,Q05639,Q96N66,Q9NZJ7,Q9Y223,Q7LGA3 23 +Toe syndactyly 0.2814820804198262 0.2161223891159431 0.828892348109382 1.0 1.0 57 Q8NCM8,Q09472,Q9H4L7,P27635,Q08J23,Q9Y4R8,O14802,P49711,P21281,Q13045,Q9UHX1,Q6DKJ4,Q9Y5P4,Q9Y223 14 +Porokeratosis 0.4235996022538841 0.2154235246049344 0.8294371305559369 1.0 1.0 4 Q03426,Q15126,Q9H1A4 3 +Neonatal hypoglycemia 0.3294357246401261 0.2144193938760442 0.830220019216795 1.0 1.0 10 O43772,P42345 2 +Enamel hypoplasia 0.3259440005129506 0.2136992724345075 0.8307815787502326 1.0 1.0 12 O00443,P51648,Q09472 3 +Kyphosis 0.3518273276769513 0.2119297392399039 0.8321618489760207 1.0 1.0 145 O00443,Q13363,Q9Y296,Q15042,Q14108,Q13155,P08236,Q9Y487,Q96AX1,Q14739,Q9BPU6,P42858,Q9Y4P8,Q9Y375,P04350,P16278,P04066,Q9NR77,Q9BT22,O75844,Q8IWS0,P51648,P48651,Q9Y4R8,Q9NUQ7,Q13509,Q6DKJ4,O00170,Q96T60,Q15233,Q86UE8,P04062,P28340,Q96AY3,O14802,P21281,Q9UHX1,Q8NCH0,Q9Y263,Q7LGA3 40 +Basal cell carcinoma 0.3286998558584609 0.2118602266737664 0.8322160807216241 1.0 1.0 10 P43246,Q9UPY3,P19447,P52701 4 +Bradycardia 0.3374634809936462 0.2111203195326297 0.8327933848718851 1.0 1.0 9 O43772,O75880 2 +Short palpebral fissure 0.2966843411044875 0.2108166429722763 0.8330303511826715 1.0 1.0 28 P07437 1 +Focal white matter lesions 0.3609599627566787 0.2095086868205398 0.834051154757613 1.0 1.0 6 O00443,Q96RR1 2 +Neoplasm of the colon 0.3001069337243521 0.207232057785193 0.8358286321971886 1.0 1.0 33 P28340,P61254,P61313,O43684,P08708,P43246,P21912,Q07864,P52701,P62244,P18077 11 +Eeg with multifocal slow activity 0.3607221203684231 0.2063877751176338 0.8364880193193711 1.0 1.0 7 Q8NC96 1 +Large earlobe 0.359951159261911 0.2042357900109938 0.8381692443625779 1.0 1.0 7 Q15392 1 +Congenital blindness 0.5591255382577133 0.2036604535657639 0.8386188479185619 1.0 1.0 2 Q96MF7 1 +Prominent digit pad 0.2902031326320181 0.2035623999519838 0.8386954783479901 1.0 1.0 24 Q09472,Q9Y296,P49711,Q9BPU6,P62266,P42858,Q7LGA3 7 +Renal hypoplasia aplasia 0.2913782562520912 0.2033878981579257 0.8388318580061718 1.0 1.0 81 Q9UBM7,O00443,Q8NCM8,Q86XL3,Q13045,Q00534,Q8TAA9,Q96I36,P49454,P16435,Q15056,Q15058,P62244,Q6PGP7,Q8WWQ0,P61313,P18077,Q92766,P61254,P08708,P35606,Q15392,Q9UHX1,Q92890,Q7LGA3 25 +Abnormally lax or hyperextensible skin 0.3005092134393122 0.2020509461588384 0.8398768961535308 1.0 1.0 39 P48651,P04062,P38435,P07437,Q9Y487,Q9UHX1,Q8NCH0,Q12948 8 +Infection related seizure 0.3054363741879217 0.2018033285820292 0.8400704792554428 1.0 1.0 20 Q96T60,Q96N66,P27635,Q96CW1,P05067 5 +Lower limb spasticity 0.2859205899244893 0.200641854972293 0.840978627980048 1.0 1.0 76 Q9Y3Z3,P07602,P04062,Q9H6K4,P00846,Q99720,Q96CU9 7 +Striae distensae 0.3328416692826432 0.1963522356773277 0.8443344788773757 1.0 1.0 9 Q15334 1 +Arthralgia 0.2975809896573247 0.1956433588993592 0.8448893205360957 1.0 1.0 32 Q9NZ08,P28070,Q15800,Q9NUQ7,O00170 5 +Pilomatrixoma 0.5433562018039292 0.1933907829168007 0.846652933351292 1.0 1.0 3 Q09472 1 +Purpura 0.2965869419519861 0.1921844949834297 0.8475976907292473 1.0 1.0 22 Q8NCH0,O00170,P04062,P38435 4 +Scleroderma 0.3667348219619052 0.1920808187283601 0.8476788995831859 1.0 1.0 5 Q14739 1 +Tetraplegia tetraparesis 0.2943452694614707 0.1909212785545223 0.8485872689351854 1.0 1.0 47 Q96T60,P07602,Q9Y296,O43681,Q9UBX3,Q9NZJ7,P43034,P00846 8 +High narrow palate 0.2973493184112366 0.190591390916948 0.8488457356072998 1.0 1.0 33 Q15233,P48651,P16435,P50542,P23786,Q9Y223 6 +Motor polyneuropathy 0.3306772908366539 0.1895776793772206 0.8496400792817265 1.0 1.0 9 P08397,P22314,P53007,P41250,P36551,P54886,P07196,O43819 8 +Generalized hirsutism 0.2904917653795429 0.1893675326312043 0.8498047692602695 1.0 1.0 26 P07437,Q15042,Q9Y223,Q9BW83 4 +Abnormal duodenum morphology 0.3193290104424392 0.1893208386729636 0.8498413637552744 1.0 1.0 12 Q8NCH0,P49454,Q09472 3 +Cns demyelination 0.312612644144802 0.1885732311671228 0.8504273148027417 1.0 1.0 15 Q9NR50,P07602,P51648,Q9NZJ7,P49770 5 +Nail dystrophy 0.2912648691081326 0.18654652777793 0.8520161952624685 1.0 1.0 27 O75844 1 +Abnormal b cell subset distribution 0.5393212691449761 0.1865242703854954 0.8520336478010839 1.0 1.0 3 P50851 1 +Hypertrichosis 0.309205404580021 0.1846133320250397 0.8535323282497629 1.0 1.0 101 Q86UE8,P16278,P54802,P03886,P21281,P49711,P00403,Q96AX1,P15586,P62266,Q9Y5P4,Q9Y223,Q96CU9 13 +Babinski sign 0.2912430778013602 0.1836658157604473 0.8542756277225805 1.0 1.0 83 P07602,O14773,Q9NR77,Q9H6K4,Q9Y6X9,P00846,Q99720,P42858 8 +Abnormality of the helix 0.2973248088684272 0.1815386366836611 0.8559448092508515 1.0 1.0 39 P37287,Q09472,Q92766,Q69YQ0,P46821,P23786,O15111,P50542,P62266,O75844,Q7LGA3 11 +Female reproductive system neoplasm 0.3011671859349947 0.1815260965680159 0.8559546513046097 1.0 1.0 20 P63167,Q09472,P28340,O43684,P43246,Q07864,P52701 7 +Ankyloblepharon 0.3617501386512373 0.1805155153216976 0.8567478750051185 1.0 1.0 5 P19447,O15111 2 +Joint swelling 0.3511698764593078 0.1804296115299848 0.856815309146814 1.0 1.0 7 O00170 1 +Abnormal circulating nucleobase concentration 0.315719702499144 0.1764212553461898 0.859963007202162 1.0 1.0 12 O43826 1 +Recurrent lower respiratory tract infections 0.2933813186765899 0.1760477940000899 0.8602563945804707 1.0 1.0 22 Q13277,P50851,P49711,P63000,O75083,P78318,Q96AX1,P09884 8 +Severe infection 0.3597098366006702 0.1758973146476873 0.8603746150607459 1.0 1.0 5 Q7L590 1 +Abnormal heart valve morphology 0.2809587216870624 0.1746122654412785 0.8613843102277845 1.0 1.0 74 Q13363,P08236,Q09472,P16278,P46821,Q6ZXV5,O75844,P06280,Q6PGP7,Q8NCH0,Q6DKJ4,Q15233,P04062,P53701,Q92766,P61254,O14802,Q9UHX1,Q9H3P2,Q92890 20 +Abnormal ovarian physiology 0.2887522914959234 0.1723617763555845 0.8631531204566438 1.0 1.0 23 Q9NR50,Q8WWQ0,Q13315,Q96RR1,O00170,P49770,O75844 7 +Abnormal conus terminalis morphology 0.3168361038928916 0.1721392914213924 0.8633280236972096 1.0 1.0 10 Q13363,Q09472 2 +Abnormal placental membrane morphology 0.5279142645087425 0.1680574013173652 0.8665381214569168 1.0 1.0 3 P21281 1 +Abnormality of the shoulder girdle musculature 0.2910962978724396 0.1673367416633887 0.8671050960260342 1.0 1.0 30 P07602,Q9Y5P6,Q9NZJ7,Q9Y487,Q9Y223 5 +Neoplasm of the male external genitalia 0.3231622430309951 0.166772578344837 0.8675489957927158 1.0 1.0 9 Q01844 1 +Depletion of mitochondrial dna in muscle tissue 0.3990452433431063 0.1652269810385944 0.868765329320621 1.0 1.0 4 Q96RR1,Q9UBX3 2 +Sleep disturbance 0.3415740463598855 0.1648083123387156 0.8690948612142044 1.0 1.0 139 Q9Y296,Q9NZ01,P49711,O75503,P42858,Q09472,Q2M389,Q12955,Q9Y5P4,P50897,Q08J23,P35270,P54802,Q96F86,Q9NUQ7,Q13509,O00170,Q96T60,Q15233,Q05639,P04062,Q96N66,Q96RR1,P15586,Q9Y223,Q7LGA3 26 +Abnormal nervous system electrophysiology 0.3632874549334839 0.1627522558526712 0.8707135012396077 1.0 1.0 166 P37287,Q9UBX3,Q9Y5P6,Q9NZ01,Q14108,O75503,Q13045,Q99720,Q13885,Q8NC96,Q09472,Q15120,P27635,Q2M389,Q96CW1,P03886,Q9NR77,P00403,P43034,O43681,Q2TAA5,Q8IWS0,P49366,P50897,Q08J23,Q96F86,Q9NUQ7,Q9Y6X9,Q96T60,P07602,Q05639,Q96N66,Q9NZJ7,O14773,Q9NPF4,P21281,P50542 37 +Short long bone 0.2878470746221336 0.1609806348204553 0.8721086528795241 1.0 1.0 28 Q8NCM8,O00116,P16278,P61254,O14802,P53597,P50542,Q9UHX1,Q96HY6 9 +Abnormal labia morphology 0.3013326318284836 0.1602244979977201 0.8727042320776204 1.0 1.0 18 P49711,P16435 2 +Peters anomaly 0.5225724612422005 0.1598900061680774 0.8729677211601317 1.0 1.0 3 Q12948 1 +Narrow foot 0.5329579330904406 0.1598031057605693 0.8730361774822082 1.0 1.0 2 P55263 1 +Abnormality of the skull base 0.27868726462871 0.1593301485557018 0.8734087690370584 1.0 1.0 55 Q8NCM8,Q09472,P48651,O14802,P15291,Q9NPL8,P21281,O43684,P07437,P23786,Q9Y487,P49748,Q9UHX1,Q14739,Q12948 15 +Abnormality of the elbow 0.2747328159749572 0.1592873866064333 0.8734424579124891 1.0 1.0 57 O00443,Q96AY3,P16435,P23786,P50542,Q9H6K4,Q13509,Q6DKJ4,Q7LGA3 9 +Abnormality of tibia morphology 0.3119215763326177 0.1591313985999771 0.8735653508996528 1.0 1.0 11 Q32P28,Q8NCM8,P16435 3 +Uric acid nephrolithiasis 0.530639284531315 0.1563234053164276 0.8757781083538125 1.0 1.0 2 P07741 1 +Macroscopic hematuria 0.530639284531315 0.1563234053164276 0.8757781083538125 1.0 1.0 2 P07741 1 +Status epilepticus 0.292094970812052 0.1550100191401796 0.8768134186492378 1.0 1.0 43 Q8NC96,P07602,Q05639,P53701,Q9NZJ7,P42892,P50542,Q9Y487,Q15392,Q13510 10 +Falls 0.3393034825870549 0.1549444486765707 0.8768651117859416 1.0 1.0 6 Q14204,Q9BQT8,P21912,P54886,Q8WVX9 5 +Proximal muscle weakness in upper limbs 0.3079809383277238 0.1546865608466786 0.8770684253518473 1.0 1.0 13 Q9Y6X9 1 +Carcinoma 0.3484450023114968 0.1516240849220571 0.8794834360181132 1.0 1.0 5 Q07864,P28340 2 +Skin nodule 0.2971316971758107 0.1513936662145364 0.8796651855056614 1.0 1.0 19 P11802,Q9NZ08,O43826 3 +Abnormality of the intrinsic pathway 0.3092544453816597 0.1504761018794683 0.8803890039843443 1.0 1.0 11 P49257,Q9Y487 2 +Death in infancy 0.2735128345129812 0.1492608956250622 0.8813477703303532 1.0 1.0 57 P07602,P04062,Q9NZJ7,P16278,P49748,Q6DKJ4 6 +Female infertility 0.5246770453792783 0.1476758926621534 0.8825985578762314 1.0 1.0 2 Q15645 1 +Abnormal abdomen morphology 0.3880288839744361 0.1471552138370383 0.8830095098505191 1.0 1.0 203 P00374,O00443,Q9Y6M9,P09601,Q14108,P08236,P10619,Q96AX1,P00846,Q96CU9,Q9Y3Z3,P28070,P16278,O15118,Q86Y39,P03886,O43826,Q01844,O75880,P54802,P23786,P49748,Q9NZ08,P10253,P07602,P04062,Q9NZJ7,P21281,P50542,Q15392,O43772,Q9Y223 32 +Broad long bones 0.2913528408369917 0.1469439937147969 0.8831762268357559 1.0 1.0 36 Q96T60,Q09472,Q9Y296,Q08J23,Q15022,P49711,Q9UHX1,Q6DKJ4,P42858,Q7LGA3 10 +Limitation of knee mobility 0.3428381962864751 0.1403231910312985 0.8884046418104488 1.0 1.0 5 Q9BPU6,Q14315,Q93063,P21333 4 +Degeneration of the lateral corticospinal tracts 0.3428381962864709 0.14032319103129 0.8884046418104554 1.0 1.0 5 Q13148,Q14203,P35637,Q12768 4 +Anteverted ears 0.5085037345071985 0.1398405021483325 0.8887860116025768 1.0 1.0 3 P27635 1 +Right ventricular hypertrophy 0.3425663037230292 0.1397884482919468 0.8888271406032779 1.0 1.0 5 Q15233 1 +Abnormality of the musculature of the upper limbs 0.2717623918526464 0.1396419183564071 0.8889429190272149 1.0 1.0 69 P07602,Q15120,P46976,Q9Y5P6,Q9NZJ7,P61254,P61313,Q9NR77,Q9BQT8,Q9Y487,P62244,P18077,Q96RR1,Q9Y223,Q9Y6X9 15 +Trichorrhexis nodosa 0.5078417691625656 0.1389490097280198 0.8894904424026921 1.0 1.0 3 Q6PGP7 1 +Abnormal blood chloride concentration 0.5167273931765622 0.1368123228512703 0.891179143011364 1.0 1.0 2 Q9UNF1 1 +Abnormality of dermal melanosomes 0.5160649221596673 0.1359410722818736 0.8918678658542412 1.0 1.0 2 Q9Y4I1 1 +Abnormal dermatoglyphics 0.2734216303256744 0.1357267354520113 0.8920373114607392 1.0 1.0 71 Q96J02,Q9Y263,Q9H4L7,Q09472,P42345,P27635,Q9Y4R8,Q15042,O00170,Q8NCH0,P49711,P21281,P50542,Q9Y487,Q96AX1,Q9UHX1,P62266,Q6DKJ4 18 +Abnormality of pain sensation 0.2774211161159817 0.1356781909840102 0.892075689343039 1.0 1.0 24 Q9NR77 1 +Abnormal sclera morphology 0.2789812540852275 0.135492268254742 0.8922226769272483 1.0 1.0 25 Q96AY3,Q9Y4R8,Q8NCH0,O75718,P62266,Q6DKJ4 6 +Abnormal renal resorption 0.3806667098398669 0.133151858420823 0.8940732831467462 1.0 1.0 4 P37287 1 +Renal fanconi syndrome 0.3806667098398669 0.133151858420823 0.8940732831467462 1.0 1.0 4 P37287 1 +Rheumatoid factor positive 0.513746273600544 0.1329326000357491 0.894246684592654 1.0 1.0 2 P49327 1 +Decreased proportion of cd3 positive t cells 0.5137462736005439 0.1329326000357491 0.894246684592654 1.0 1.0 2 P00491 1 +Cleft soft palate 0.2714470962803616 0.1324660641176618 0.8946156633573852 1.0 1.0 57 Q15436,Q6PGP7,P48651,Q15233,Q69YQ0,P61254,O14802,P61313,P21281,P78318,Q15392,P62244,P18077,Q9Y619,P62266 15 +Abnormality of upper limb metaphysis 0.5124213315667547 0.1312419384734564 0.8955839207520151 1.0 1.0 2 Q9H1A4 1 +Arthropathy 0.3787221737747974 0.1300354552668682 0.8965383755822001 1.0 1.0 4 Q9Y3Z3 1 +Aplastic clavicle 0.500811348060136 0.1297660751683866 0.8967515040092136 1.0 1.0 3 P48651 1 +Proptosis 0.288617485597986 0.1284547927070167 0.8977890719554233 1.0 1.0 41 Q96J02,Q6PGP7,Q13363,Q09472,P28340,Q69YQ0,P16435,Q9H3P2,O75718,Q9BPU6,Q6DKJ4,O75844,Q12948 13 +Reduced factor xii activity 0.5101026830076306 0.1283328351488725 0.8978855812442672 1.0 1.0 2 Q02750 1 +Pectus excavatum of inferior sternum 0.5101026830076306 0.1283328351488725 0.8978855812442672 1.0 1.0 2 Q02750 1 +Reduced factor xiii activity 0.5101026830076306 0.1283328351488725 0.8978855812442672 1.0 1.0 2 Q02750 1 +Amegakaryocytic thrombocytopenia 0.5101026830076306 0.1283328351488725 0.8978855812442672 1.0 1.0 2 Q02750 1 +Abnormal urine metabolite level 0.3482803280461437 0.1279990498521876 0.898149724964638 1.0 1.0 152 O00443,P09601,Q14108,P08236,Q96AX1,P53985,P16278,P03886,P00403,O43826,P54802,P23786,Q9H6K4,P49748,P10253,P04062,Q9NPF4,P21281,O95470,P50542,P15586 21 +Molluscum contagiosum 0.5097714474991859 0.127922378759127 0.8982104008551994 1.0 1.0 2 O95394 1 +Unusual skin infection 0.5097714474991859 0.127922378759127 0.8982104008551994 1.0 1.0 2 O95394 1 +Urinary incontinence 0.2885172144916258 0.1273421220621207 0.8986696230716273 1.0 1.0 38 P07602,Q9NZJ7,Q8TAA9,Q9Y6X9,Q99720 5 +Peripheral cyanosis 0.3192873483198652 0.1267968480865765 0.8991011904657091 1.0 1.0 8 Q9Y3Z3 1 +Erythrocyte inclusion bodies 0.3765329797812274 0.1265902561222921 0.8992647093818049 1.0 1.0 4 O14936,P11413,Q9Y606 3 +Eversion of lateral third of lower eyelids 0.5084465054653972 0.1262933294702333 0.8994997362935837 1.0 1.0 2 P61978 1 +Femoral bowing 0.3188435822986548 0.1257123768466795 0.8999596042902831 1.0 1.0 8 Q8NCM8,P16435 2 +Abnormality of skin pigmentation 0.3256658137233586 0.1246410376296776 0.9008077383781614 1.0 1.0 126 P37287,Q9Y296,P11802,P50851,Q15022,Q6UX04,Q13315,Q14739,Q9BPU6,P42858,Q8IZA0,Q09472,P03886,P00403,P07437,O75844,Q6PGP7,P51648,P42345,Q8WWQ0,Q08J23,P52701,P16615,O00170,P07602,Q15436,Q9H4L7,P04062,Q92766,Q96AY3,Q9NZJ7,P53701,O43684,P21281,P19447,Q92890,Q7LGA3 37 +Abnormally folded helix 0.2857960559153736 0.1245068779956757 0.9009139549032924 1.0 1.0 21 P37287,Q92766,P23786,O15111,Q92890,P62266 6 +Sound sensitivity 0.3178532227994272 0.1233061825941066 0.9018646451947516 1.0 1.0 8 Q13045,Q09472,P17900 3 +Aspiration 0.3000178751912334 0.1217709391555507 0.9030804298334558 1.0 1.0 11 P17900,Q09472,P29372 3 +Decreased lacrimation 0.324046434494191 0.1214378577457685 0.9033442326090628 1.0 1.0 6 P55011,Q10567,Q7Z392,O95163,Q96IJ6 5 +Partial duplication of the phalanx of hand 0.2930490623340633 0.1199738459073721 0.9045038662284366 1.0 1.0 17 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Patent foramen ovale 0.2741166961352993 0.1190686065032047 0.9052210021522902 1.0 1.0 24 O95630,Q15233,Q09472,P53597,P63000,P29401,P49748,Q96AX1 8 +Patellar dislocation 0.2912749891001862 0.1187197441156118 0.9054973936330972 1.0 1.0 18 Q09472,Q92766,P46821,Q15056,Q6ZXV5,Q92890 6 +Abnormal anterior horn cell morphology 0.321583482478339 0.1164210931642317 0.9073188191335906 1.0 1.0 6 Q13510 1 +Persistence of hemoglobin f 0.290605903456839 0.1160620995518581 0.9076033259416514 1.0 1.0 18 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Irregular hyperpigmentation 0.2647969710659907 0.1160537204844986 0.9076099665962504 1.0 1.0 65 Q9Y296,Q6UX04,Q13315,Q14739,Q9BPU6,P42858,Q09472,P07437,O75844,Q6PGP7,P42345,Q8WWQ0,P52701,P16615,Q15436,Q9H4L7,O43684,P19447,Q7LGA3 19 +Duplication involving bones of the feet 0.2886231492357296 0.1154392457333978 0.9080969732799868 1.0 1.0 19 Q8NCM8,Q13363,Q92766,Q92890,Q14739,Q9Y263 6 +Abnormal aortic valve morphology 0.2866024057398662 0.1153475560477633 0.9081696456110876 1.0 1.0 39 Q6PGP7,Q09472,Q92766,P04062,P61254,P63000,Q9UHX1,Q92890,Q6DKJ4,O75844,P06280 11 +Abnormal cell proliferation 0.3681790434785966 0.1140568966967219 0.909192690628329 1.0 1.0 4 P17812 1 +Albinism 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Abnormal size of the clitoris 0.2946319347919347 0.1136929920923472 0.9094811679998176 1.0 1.0 14 P50542,Q9Y619,P53701,P16435 4 +Pancreatic adenocarcinoma 0.3211678832116823 0.1093231440945181 0.912946190278904 1.0 1.0 7 Q16658,P04637,P43246,Q8WX93,P52701,Q6P1J9 6 +Antinuclear antibody positivity 0.4831013916500942 0.1089087972461606 0.9132748289600916 1.0 1.0 3 P49327,P53621 2 +Abnormality of male internal genitalia 0.3017909632989916 0.108284018608482 0.9137703993731126 1.0 1.0 9 Q09472 1 +Male hypogonadism 0.3205682742169254 0.1080686927187953 0.9139412022679628 1.0 1.0 7 O00170,Q8WWQ0 2 +Bicornuate uterus 0.3247602648350044 0.1074494852751284 0.9144323981358732 1.0 1.0 5 Q9UBM7,Q69YQ0 2 +Chorioretinal dysplasia 0.3632882356870325 0.1071672071363721 0.914656330485578 1.0 1.0 4 P53701 1 +Alacrima 0.3239389920424395 0.1060851395891661 0.91551480149789 1.0 1.0 5 P55011,Q96IJ6,Q7Z392,O95163 4 +Hydranencephaly 0.4902285525008429 0.1059229277364024 0.9156435026971346 1.0 1.0 2 O43175 1 +Abnormality of dental structure 0.2656108102503979 0.1048128840753749 0.9165242863506684 1.0 1.0 67 O00443,P51648,Q09472,Q15436,P53701,Q96AY3,P16278,Q13045,O43826,Q9Y487,O75844 11 +Short middle phalanx of finger 0.4791945482200037 0.104736608797424 0.9165848120857614 1.0 1.0 3 Q8IWS0 1 +Irritability 0.2654673544244618 0.1035925593398666 0.9174926926804076 1.0 1.0 67 Q9NZ08,Q9Y3Z3,P07602,P50897,P00846,O43772,P42858 7 +Aphasia 0.2844837449709668 0.1031299165099667 0.9178598616671664 1.0 1.0 41 P00403,Q7LGA3,P42858,P03886 4 +Abnormal c peptide level 0.359628770301613 0.1022262961945287 0.9185770557447812 1.0 1.0 4 O00330,Q16836,A5YKK6 3 +Spontaneous abortion 0.4862537263994851 0.1019668654044547 0.9187829755402912 1.0 1.0 2 P50570 1 +Hamartomatous polyposis 0.4754804506295502 0.1009106181210078 0.9196214140953364 1.0 1.0 3 P21912,P20585 2 +Aplasia hypoplasia of the optic nerve 0.2771484880231415 0.0994060695002353 0.9208158638709454 1.0 1.0 22 Q96KP1,Q8WWQ0,Q9Y5P6,P49454,O14802,Q15058,Q9UHX1,P07196,Q13509 9 +Shawl scrotum 0.3160878468636511 0.0989054093819875 0.9212133739026838 1.0 1.0 7 Q9Y619,Q09472 2 +Abnormal systemic arterial morphology 0.3314566285018349 0.0986983339311079 0.9213777917380752 1.0 1.0 136 P10253,Q9Y3Z3,P07602,P04062,Q96DF8,P16278,O15118,P61313,P03886,P49711,P05067,Q6ZXV5,P10619,Q6DKJ4,P00846,P42858,O75844,Q7LGA3 18 +Hyposmia 0.2899565816544709 0.0980819908627314 0.92186718777705 1.0 1.0 14 P04062 1 +Papilledema 0.2841759494193371 0.0975222801337313 0.92231164157169 1.0 1.0 19 P04062,Q7LGA3 2 +Cerebellar atrophy 0.3276837589777214 0.0962365562909172 0.9233326978208004 1.0 1.0 132 Q8IV08,Q9BVA1,P04350,O14773,Q9NPF4,Q14108,O75503,P07437,Q5JRX3,Q9H6K4,Q9Y6X9,P42858,Q96CU9 13 +Abnormal number of erythroid precursors 0.2694001245689956 0.0960750220316394 0.9234609890529086 1.0 1.0 24 P37287,P00491,P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,Q9Y606,P46777 12 +Abnormal atrioventricular valve physiology 0.2827970875167471 0.0957854368223829 0.9236909839048092 1.0 1.0 43 Q9NZ08,Q15233,P04062,P49711,Q96AX1,O00170,O75844 7 +Aplasia hypoplasia of the nails 0.2611848071320045 0.0943851519314822 0.9248032101902308 1.0 1.0 64 Q96T60,O95630,P37287,P48651,Q9H4L7,Q08J23,Q9Y4R8,Q6UX04,O14802,P21281,P23786,Q9Y487,Q14739,P63241,O75844 15 +Bilateral microphthalmos 0.3165404142177171 0.0942962147338942 0.9248738567236052 1.0 1.0 5 P19447,Q9UHX1 2 +Hereditary nonpolyposis colorectal carcinoma 0.3051910890227697 0.0942656999723494 0.9248980960106752 1.0 1.0 8 P63167,Q09472 2 +Short lower limbs 0.4776416031798763 0.0939695026154593 0.9251333828965858 1.0 1.0 2 Q93063 1 +Periventricular heterotopia 0.2900758783614681 0.0939258408584688 0.9251680665383756 1.0 1.0 10 Q9UBM7,P46821,Q6ZXV5 3 +Unusual fungal infection 0.2899368980405159 0.0935630010325676 0.9254563015383696 1.0 1.0 10 P40818,Q13043,P02786,Q03426,O14920,O00203,O75083,Q9Y5L0,O95394 9 +Capillary malformation 0.290206241699962 0.0935023050365486 0.9255045185646522 1.0 1.0 11 Q6DKJ4,P42345,Q9UHX1 3 +Abnormality of fibula morphology 0.2901219627203727 0.0932696351075531 0.9256893545767502 1.0 1.0 11 Q96HY6,Q8NCM8,P16435 3 +Microglossia 0.3523914141868662 0.0929878647911672 0.9259132019432874 1.0 1.0 4 P48651 1 +Aplasia hypoplasia of the tongue 0.3523914141868662 0.0929878647911672 0.9259132019432874 1.0 1.0 4 P48651 1 +Abnormal circulating iga level 0.2895528585116785 0.0920167532544444 0.926684728890396 1.0 1.0 12 Q96J02,Q13315,P42345 3 +Skeletal myopathy 0.3146551724137932 0.0914359803157488 0.92714617332248 1.0 1.0 5 P21912,P04075,P31040,P40939 4 +Unusual infection by anatomical site 0.2861926443961203 0.0913218772394375 0.9272368350962632 1.0 1.0 16 Q9NZ08,Q8TAA9 2 +Periventricular cysts 0.3120247809909385 0.0909169095636892 0.9275586139498864 1.0 1.0 7 O00330,Q13363 2 +Malar prominence 0.4648774022531428 0.0907254010977752 0.9277107867047744 1.0 1.0 3 O60934,Q96MF7 2 +Pollakisuria 0.347033476963865 0.0865979014532174 0.9309911340331416 1.0 1.0 4 O60934,Q06787,Q8WVX9 3 +Dysgraphia 0.2876317166039623 0.0864737337695355 0.931089835258634 1.0 1.0 11 P43246,P05067,Q15056,P52701 4 +Hypoplastic toenails 0.270934655795854 0.0861926583686625 0.9313132667626968 1.0 1.0 23 Q08J23,Q9Y4R8,P21281,P23786,P63241 5 +Tracheal stenosis 0.4597573907265524 0.0861885193317597 0.9313165569923544 1.0 1.0 3 Q9UBM7 1 +Neoplasm of the pancreas 0.2766371464415647 0.0849644003857907 0.93228969271039 1.0 1.0 21 P11802 1 +Abnormality of the calcaneus 0.3041459369817524 0.0840430518883993 0.9330222023694796 1.0 1.0 6 O43175,P21333,P40939,P55084,Q14739 5 +Progressive cerebellar ataxia 0.2806297765099847 0.0833736134533284 0.9335544688625048 1.0 1.0 37 O14773,P42858,Q96CU9 3 +Immunologic hypersensitivity 0.2753389974191968 0.0829561774820357 0.9338863847581926 1.0 1.0 30 Q9NZ08,Q09472,P42345,Q92766,Q08J23,P50851,P50542,Q92890 8 +Aplasia hypoplasia affecting the eye 0.2845698394767788 0.0818718668924486 0.9347486062820592 1.0 1.0 88 Q9UBM7,Q13363,Q9Y5P6,Q15042,Q96I36,Q96CW1,P49454,P07437,Q15056,Q15058,Q12948,Q96KP1,Q8WWQ0,O15111,Q13509,Q92766,P53701,O15347,Q9NPF4,O14802,O43684,P19447,Q02252,Q9UHX1,Q92890,Q7LGA3 26 +Abnormal renal collecting system morphology 0.302616483482586 0.0814650345832085 0.9350721307857092 1.0 1.0 6 Q9Y4R8,P37287 2 +Abnormal adipose tissue morphology 0.2742944099958908 0.081048699903377 0.9354032229427138 1.0 1.0 51 Q9Y3Z3,P28070,P27635,P04066,Q9Y487,Q8TAA9,Q2TAA5,O75844 8 +Supernumerary nipple 0.285575515805317 0.0806658765426129 0.9357076749230004 1.0 1.0 12 Q7LGA3 1 +Chronic lung disease 0.2978934693504775 0.0789943132880547 0.937037146268728 1.0 1.0 8 Q96J02,P49711 2 +Platybasia 0.3042468480424717 0.0764769778511854 0.9390396293385616 1.0 1.0 7 Q92766,O00192,Q92890,P53992,P21964,P54198 6 +Fused cervical vertebrae 0.3040450928381957 0.0764121924665034 0.9390911697811656 1.0 1.0 5 Q9NVI1,Q9Y2W2,Q9UHX1,P21333 4 +Nail dysplasia 0.2727324329999249 0.0759098942164961 0.939490785127962 1.0 1.0 29 P48651,Q13363,Q15022,P42892,P21281,P16615,Q9Y619,Q6DKJ4 8 +Abnormal form of the vertebral bodies 0.2715392836666674 0.0753287408331102 0.9399531545626524 1.0 1.0 76 Q96J02,Q13045,P08236,Q8TAA9,Q14739,P16278,P04066,P16435,P63241,P54802,Q9NUQ7,O00170,Q15436,Q96AY3,O14802,P21281,Q9UHX1,Q9Y619,P15586 19 +Anotia 0.3350797395884694 0.073681210792609 0.94126404975975 1.0 1.0 4 O15111 1 +Open bite 0.281126275444824 0.0732866803120412 0.941577990768136 1.0 1.0 15 P21281 1 +Ventriculomegaly 0.3607484942413049 0.0732091656934618 0.9416396727933788 1.0 1.0 176 Q8NCM8,Q9BVA1,Q9Y5P6,Q86XL3,Q15042,P49711,Q13045,Q00534,Q9Y487,P00846,P42858,Q13885,Q96CU9,Q9Y3Z3,P16278,Q7Z460,P15291,Q16625,P07437,Q6ZXV5,P43034,P42345,P23786,Q13509,Q96T60,P07602,Q05639,P04062,Q9NZJ7,O14802,Q9NPF4,P21281,Q9NPL8,O43684,P26358,Q9UHX1,Q15392,Q8NCH0,Q9Y263 39 +Submucous cleft soft palate 0.4425102196736059 0.0726453825254442 0.9420883120665058 1.0 1.0 3 Q15233 1 +Hypophosphatemia 0.3334438183626053 0.0720537270502027 0.9425591509215374 1.0 1.0 4 P16930,Q01968,Q08426 3 +Megalocornea 0.2819291098502223 0.0706161835986644 0.9437032299188312 1.0 1.0 12 Q9H3P2,Q9Y5P6,Q96EK5,Q13363 4 +Duplicated collecting system 0.2992148121940519 0.070166858851239 0.944060852093248 1.0 1.0 5 P37287 1 +Hodgkin lymphoma 0.3004371249447936 0.0698117119962386 0.9443435250987736 1.0 1.0 7 Q13315 1 +Abnormal serum interleukin level 0.4377070907885955 0.0693294878777707 0.9447273542694532 1.0 1.0 3 P49327,P09884 2 +Elevated urinary delta aminolevulinic acid 0.3301292674842519 0.0688570778036486 0.9451033843368736 1.0 1.0 4 P16930,P08397,P36551 3 +Chromosomal breakage induced by crosslinking agents 0.4425306392845399 0.0688107954402961 0.9451402249391344 1.0 1.0 2 Q9NVI1 1 +Subependymal cysts 0.4328152247708556 0.0661459852388935 0.9472616000642607 1.0 1.0 3 Q9BSJ2 1 +Abnormal protein o linked glycosylation 0.437230871149404 0.0659438566900689 0.947422523959876 1.0 1.0 2 Q10471 1 +Decreased circulating copper concentration 0.4372308711493999 0.0659438566900667 0.9474225239598776 1.0 1.0 2 Q10567 1 +Retrognathia 0.2732647875521818 0.0640209173950222 0.9489535712994596 1.0 1.0 79 O00443,Q13363,Q09472,P04062,P27635,Q96DF8,P53701,Q9Y4R8,O14802,Q16625,P78318,Q9UHX1,Q15392,Q8NCH0,Q9Y619,Q2TAA5,O75844,Q7LGA3 18 +Low posterior hairline 0.2744815517855463 0.0635635594781316 0.9493177483624458 1.0 1.0 33 O00443,Q15042,Q9Y223,Q96AX1 4 +Wide mouth 0.256487212351704 0.0632481605148452 0.9495688949742124 1.0 1.0 60 Q15436,Q15233,P48651,Q08J23,Q96CW1,P16278,P49454,P21281,P15586,Q6DKJ4,Q7LGA3 11 +Abnormality of the hypothenar eminence 0.3238316208153755 0.0631481071863319 0.949648566716651 1.0 1.0 4 Q96IJ6,P62913,Q7Z392 3 +Central primitive neuroectodermal tumor 0.4273970151954053 0.0628407778512398 0.9498932939896028 1.0 1.0 3 Q9UPY3 1 +Cystathioninemia 0.4302749254720265 0.0625069265228971 0.9501591461605592 1.0 1.0 2 P32929 1 +Macular coloboma 0.4302749254720233 0.0625069265228957 0.9501591461605604 1.0 1.0 2 Q92620 1 +Breathing dysregulation 0.4257786613651361 0.0618973709319179 0.950644561177739 1.0 1.0 3 Q10713,O75380 2 +Hyperkalemia 0.4247846255798478 0.0613277109197847 0.9510982222100052 1.0 1.0 3 Q13423,Q13618 2 +Neutropenia in presence of anti neutropil antibodies 0.2895522388059681 0.0611419034296982 0.9512461974456904 1.0 1.0 6 Q96J02,P49327,P00491,P29144,O95394 5 +Profound global developmental delay 0.281034552629227 0.0609402982616836 0.9514067556962456 1.0 1.0 9 P50542 1 +Abnormality of taste sensation 0.425637628353776 0.060410824060724 0.9518284380499702 1.0 1.0 2 Q12756 1 +Neoplasm of the respiratory system 0.2780629785331518 0.0600340568079006 0.9521285101864184 1.0 1.0 13 Q9UPY3,Q01844,P52701 3 +Schistocytosis 0.4218025182239836 0.0596629024090257 0.9524241186637016 1.0 1.0 3 P41440,Q05682 2 +Atrophy degeneration involving the spinal cord 0.2802451015069281 0.0593276644420662 0.952691126879069 1.0 1.0 9 Q9Y6X9 1 +Recurrent sinusitis 0.3191912495856756 0.0592391478995163 0.95276162886241 1.0 1.0 4 P50851,Q15833,Q86Y56 3 +Pustule 0.4219940377608611 0.0588681661144618 0.953057113822465 1.0 1.0 2 P00338 1 +Acanthocytosis 0.421662802252412 0.0587323450242919 0.953165296192861 1.0 1.0 2 Q05682 1 +Anisopoikilocytosis 0.421662802252412 0.0587323450242919 0.953165296192861 1.0 1.0 2 Q05682 1 +Autoimmune thrombocytopenia 0.289456233421752 0.0586506901218052 0.9532303352624728 1.0 1.0 5 P49327,P50851,P00491,P29144 4 +Bilateral cryptorchidism 0.2794164103507535 0.0576497191920141 0.9540276453091664 1.0 1.0 9 Q15233,P78318,P27635 3 +Duplication of hand bones 0.2696306157791113 0.0575885890236669 0.9540763392284553 1.0 1.0 52 Q8NCM8,Q13363,Q9BW83,Q92766,P61254,Q9H3P2,P61313,P08708,Q92890,Q13045,Q9UHX1,P62244,Q14739,P18077,Q9Y263 15 +Reduced tendon reflexes 0.3425046610086207 0.0572638643275708 0.9543350051864068 1.0 1.0 155 Q9Y5P6,Q16637,Q13315,Q13045,Q96AX1,Q8TAA9,P00846,Q99720,Q8NC96,Q15120,P03886,Q9NR77,Q9BQT8,O43681,P54802,Q9H6K4,Q9Y6X9,Q13510,Q96T60,P10253,P07602,Q8TEQ6,Q05639,P04062,Q96AY3,Q9NZJ7,P21281,P50542,Q9Y223,Q96RR1,O00764 31 +Abnormal periventricular white matter morphology 0.2756344987356035 0.0561996953052341 0.9551827238920898 1.0 1.0 37 P07602,Q13363,P27635,Q9Y5P6,Q9NZJ7,O75503,P63000,P17900,P19447,Q9UHX1,Q93009,O43681,Q9Y6X9 13 +Posterior pituitary dysgenesis 0.4144814030159782 0.0558489545207612 0.9554621357047548 1.0 1.0 3 Q9UHX1 1 +Chronic hepatic failure 0.3145508783559745 0.0555747739691796 0.9556805608945432 1.0 1.0 4 Q13043,Q10713,P40939 3 +Temporal optic disc pallor 0.4123882080159089 0.0552150012558757 0.9559671778932728 1.0 1.0 2 O60313 1 +Morning glory anomaly 0.4123882080159089 0.0552150012558757 0.9559671778932728 1.0 1.0 2 O60313 1 +Moderately reduced visual acuity 0.4125248508946257 0.0548933604442699 0.956223421503042 1.0 1.0 3 P63000,O60313 2 +Spastic paraparetic gait 0.4104007949652383 0.0545301001513855 0.9565128278058224 1.0 1.0 2 Q12756 1 +Secundum atrial septal defect 0.4104007949652302 0.0545301001513827 0.9565128278058246 1.0 1.0 2 P62913 1 +Abnormality of the common coagulation pathway 0.2756629191363948 0.0540352677885014 0.9569070656437207 1.0 1.0 14 P49257,Q7L590,Q4KMQ2 3 +Squamous cell carcinoma of the skin 0.3117900006084684 0.0535075661031057 0.9573275024086364 1.0 1.0 4 P19447,Q9H4L7 2 +Increased laxity of ankles 0.4064259688638699 0.0532290885112079 0.9575493791816204 1.0 1.0 2 O95140 1 +Low hanging columella 0.2751385840546632 0.052820474179454 0.9578749482346828 1.0 1.0 12 Q96J02,Q13155,Q09472 3 +Dilated third ventricle 0.4073924186777148 0.0525093503362624 0.9581228451236404 1.0 1.0 3 P26358 1 +Chronic mucocutaneous candidiasis 0.289648307896488 0.0523772185106767 0.9582281261904406 1.0 1.0 7 P02786,Q03426,O14920,O00203,O75083,O95394 6 +Autoimmune hemolytic anemia 0.2896483078964864 0.0523772185106742 0.9582281261904426 1.0 1.0 7 P49327,P50851,P00491,P29144,Q969U7,O60934 6 +Abnormal cellular phenotype 0.3619073006715382 0.051398309645295 0.9590081317023462 1.0 1.0 181 O00443,Q9UBX3,Q9Y6M9,P09601,Q14108,O75503,Q96AX1,P00846,Q96CU9,P28070,Q86Y39,P03886,P00403,Q70HW3,O75844,O75880,Q96DF8,P23786,P49748,P07602,P04062,Q9NZJ7,O14773,P50542,O43772,Q9Y223 26 +Functional intestinal obstruction 0.3945014905598041 0.0498388196655778 0.9602508314869056 1.0 1.0 2 Q8WX93 1 +Ovarian carcinoma 0.3945014905598041 0.0498388196655778 0.9602508314869056 1.0 1.0 2 Q8WX93 1 +Extrahepatic cholestasis 0.3945014905598041 0.0498388196655778 0.9602508314869056 1.0 1.0 2 Q8WX93 1 +Peritoneal abscess 0.3945014905598041 0.0498388196655778 0.9602508314869056 1.0 1.0 2 Q8WX93 1 +Hyperaldosteronism 0.3945014905598007 0.0498388196655769 0.9602508314869064 1.0 1.0 2 Q01968 1 +Choroid plexus carcinoma 0.3945014905597973 0.0498388196655761 0.9602508314869068 1.0 1.0 2 O96017 1 +Lung adenocarcinoma 0.3945014905597961 0.0498388196655758 0.9602508314869072 1.0 1.0 2 P30154 1 +Congenital hepatic fibrosis 0.4000442249945209 0.0493928583518695 0.9606062194267256 1.0 1.0 3 Q8NCM8 1 +Low molecular weight proteinuria 0.3908578999668891 0.0489442759293825 0.9609637040335128 1.0 1.0 2 Q01968 1 +Bicarbonaturia 0.3908578999668891 0.0489442759293825 0.9609637040335128 1.0 1.0 2 Q01968 1 +Abnormal urine potassium concentration 0.3908578999668859 0.0489442759293817 0.9609637040335136 1.0 1.0 2 P05023 1 +Atelectasis 0.2721648754587596 0.0477258828136989 0.961934706100462 1.0 1.0 11 Q92890,Q92766,Q13510 3 +Choriocarcinoma 0.3946322067594369 0.0473091892706364 0.9622668043059766 1.0 1.0 3 O96017,O95999 2 +Intellectual disability borderline 0.3812520702219375 0.0468694471288145 0.9626172789814108 1.0 1.0 2 Q7Z392 1 +Hypouricemia 0.3909874088800494 0.0460019096907487 0.9633087278095424 1.0 1.0 3 Q9NQX3,P00491 2 +Small nail 0.2726124796987618 0.0455517857948629 0.9636674986108372 1.0 1.0 47 O95630,P37287,P48651,Q9H4L7,Q08J23,Q9Y4R8,Q6UX04,O14802,P21281,P23786,Q14739,P63241 12 +Increased c peptide level 0.3593905266644692 0.0434430392905558 0.9653483696752128 1.0 1.0 2 Q16836 1 +Focal tonic seizure 0.3580655846306835 0.0432839995320519 0.965475145792316 1.0 1.0 2 Q9H936 1 +Follicular thyroid carcinoma 0.3807157057654025 0.0427071238866892 0.9659350007122688 1.0 1.0 3 P21912,Q15437 2 +Increased circulating igg level 0.3783962889330613 0.042038201066606 0.9664682449732016 1.0 1.0 3 P49327,O95394 2 +Split nail 0.2925187254483909 0.0412746991620852 0.9670769030210996 1.0 1.0 4 P19447 1 +Adenocarcinoma of the small intestine 0.3206359721762285 0.0404025436644845 0.967772202355738 1.0 1.0 2 P43246 1 +Duodenal adenocarcinoma 0.3206359721762285 0.0404025436644845 0.967772202355738 1.0 1.0 2 P43246 1 +Hemifacial spasm 0.3130175554819598 0.0400960274078961 0.9680165689258317 1.0 1.0 2 Q10713 1 +Absent forearm bone 0.3037429612454571 0.0398062665893766 0.9682475801770108 1.0 1.0 2 Q15427 1 +Bell shaped thorax 0.3037429612454572 0.0398062665893766 0.9682475801770108 1.0 1.0 2 Q96HY6 1 +Moderate albuminuria 0.2894998343822581 0.0394988987533566 0.9684926315007027 1.0 1.0 2 O00330 1 +Abnormal renal vascular morphology 0.2891685988738116 0.0394933481715689 0.9684970567712816 1.0 1.0 2 P21912 1 +Lipodystrophy 0.2686029860801935 0.0391723728483218 0.9687529599978172 1.0 1.0 32 Q9Y3Z3,P28070,P04066,Q9Y487,O75844 5 +Neoplasm of the tongue 0.2877030162412941 0.0387741265360227 0.969070473350342 1.0 1.0 4 P49327,Q8NCM8,Q969G3 3 +Long eyelashes 0.2711134915982492 0.0386943117192611 0.969134108605182 1.0 1.0 35 P21281,P49711,Q96AX1,P62266,Q6DKJ4 5 +Leukopenia 0.2733012745932772 0.0386659789742847 0.969156697960068 1.0 1.0 42 Q14108,P04062,Q96AX1 3 +Wide nose 0.2693577753555418 0.0380817074695861 0.9696225360546936 1.0 1.0 33 O95630,Q8NCM8,Q15436,P53701,P04066,O43684,P21281,Q96AX1,P43034,O00170 10 +Fulminant hepatic failure 0.359509609012586 0.0375038787499688 0.9700832475289528 1.0 1.0 3 Q16836,Q96RP9 2 +Abnormal pyramidal sign 0.3061808428884559 0.0374431508442679 0.9701316673782427 1.0 1.0 116 Q9Y5P6,P00846,Q99720,P42858,Q9Y3Z3,Q96CW1,Q8N2K0,P04066,Q9NR77,Q8TD30,O43681,P51648,Q8TB37,Q9H6K4,P52701,Q9Y6X9,Q9NZ08,P07602,Q9NZJ7,O15382,O14773,O14802,P26358,Q9Y619 24 +Nemaline bodies 0.3547402577221197 0.036589637676701 0.9708122059351548 1.0 1.0 3 Q9Y281 1 +Genetic anticipation 0.3469184890656014 0.0352649994476012 0.9718684323557516 1.0 1.0 3 Q9UBB4,Q99700 2 +Poikiloderma 0.278840172625241 0.034694954501442 0.9723229842314562 1.0 1.0 4 P19447 1 +Abnormal urine phosphate concentration 0.3333333333333285 0.0334189090381818 0.9733405308520902 1.0 1.0 3 Q08426,Q01968 2 +Hyperphosphaturia 0.3333333333333285 0.0334189090381818 0.9733405308520902 1.0 1.0 3 Q08426,Q01968 2 +Respiratory paralysis 0.330019880715701 0.0330456003797059 0.973638223636592 1.0 1.0 3 P08397,P36551 2 +Elevated urinary dicarboxylic acid level 0.330019880715701 0.0330456003797059 0.973638223636592 1.0 1.0 3 P08397,P36551 2 +Porphyrinuria 0.330019880715701 0.0330456003797059 0.973638223636592 1.0 1.0 3 P08397,P36551 2 +Fibular hypoplasia 0.2610748130141325 0.0329439551515184 0.9737192806612148 1.0 1.0 5 Q8NCM8 1 +Calvarial hyperostosis 0.2727875372886905 0.0322717746169141 0.9742553180689844 1.0 1.0 4 P09651,P22626,P55072 3 +Neurofibromas 0.3131212723657999 0.0315305496422632 0.9748464291600838 1.0 1.0 3 P21912,Q01082 2 +Radial bowing 0.3038436050364432 0.0309303333720537 0.975325098958102 1.0 1.0 3 P21333,Q32P28 2 +Broad face 0.3038436050364434 0.0309303333720537 0.975325098958102 1.0 1.0 3 Q6PJG6,P21333 2 +Tibial bowing 0.3038436050364432 0.0309303333720537 0.975325098958102 1.0 1.0 3 P21333,Q32P28 2 +Fatiguable weakness of proximal limb muscles 0.3021868787276293 0.0308375341373145 0.975399106731361 1.0 1.0 3 Q9Y281,Q14315 2 +Progressive leukoencephalopathy 0.2635211112481163 0.0295532141391155 0.9764233787068128 1.0 1.0 3 Q9Y263 1 +Elevated hemoglobin a1c 0.2607687210072835 0.0295077728439826 0.9764596198091462 1.0 1.0 3 O00330,Q96MF7 2 +Scapular winging 0.2568266611117781 0.0264069074447975 0.9789327847281716 1.0 1.0 23 Q9Y5P6,Q9Y223 2 +Aplasia hypoplasia of the cerebellar vermis 0.2560235405934863 0.026269512905585 0.9790423716927584 1.0 1.0 67 Q8NCM8,Q9Y5P6,P49454,Q15042,O14802,P15291,P21281,O43684,P07437,P23786,Q9Y487,P43034,Q13509,Q12948 14 +Aplasia hypoplasia involving bones of the lower limbs 0.2756571475941603 0.0258643826058105 0.9793655090995674 1.0 1.0 86 Q9UBM7,O00443,Q8NCM8,Q13363,Q9Y296,O00116,P53597,Q93009,Q9BPU6,P42858,Q9Y5P4,Q8IWS0,Q08J23,Q9Y4R8,O15111,Q13509,Q13510,Q96AY3,Q69YQ0,O14802,P21281,P50542,Q9UHX1,Q9H3P2,Q9Y619,Q96PZ0,Q7LGA3 27 +Brachycephaly 0.2516826901520556 0.0256747386334685 0.9795167728636996 1.0 1.0 63 P04062,Q96AY3,Q15042,P16435,P21281,P07437,Q8NCH0 7 +Abnormal circulating albumin concentration 0.2601242413410016 0.0237644642573596 0.9810404854536487 1.0 1.0 28 Q9NPF4,Q96AX1 2 +Talipes equinovarus 0.2692317266249399 0.0234047134072712 0.9813274452817852 1.0 1.0 80 Q96AY3,P16435,Q9NR77,P50542,P08236,Q9Y487,Q15392,Q8NCH0,Q6ZXV5 9 +Bulbar palsy 0.2584613888996065 0.0233761183834736 0.9813502545693225 1.0 1.0 10 O43681 1 +Abnormality of the cerebrospinal fluid 0.3189017439196862 0.0233536015716218 0.9813682154826068 1.0 1.0 132 Q9Y5P6,Q9Y6M9,P08236,Q96AX1,Q8TAA9,P00846,Q96CU9,Q9Y3Z3,P49454,Q86Y39,P15291,P03886,Q9NR77,P16435,P00403,Q16625,O43681,P48651,Q08J23,Q8TB37,P23786,Q13509,P07602,P04062,P53701,Q9NZJ7,O15382,O14802,Q9NPL8,Q15392 30 +Aplasia hypoplasia of fingers 0.2741074328705781 0.0216345759574541 0.9827394523551168 1.0 1.0 85 Q9UBM7,O00443,Q13363,Q6UX04,Q9NZN8,Q9Y4P8,P38435,O95630,P27635,P16435,P62244,Q8IWS0,O75844,P42345,Q08J23,P61313,P18077,Q6DKJ4,Q13510,Q96T60,P61254,P21281,P08708,Q9UHX1,Q9H3P2 25 +Upper extremity joint dislocation 0.2643536516802766 0.0215844509194245 0.982779437012137 1.0 1.0 17 Q9Y619,Q09472,Q6DKJ4,Q6ZXV5 4 +Abnormal t cell morphology 0.2629365729702392 0.021225296275943 0.9830659353157885 1.0 1.0 13 Q13315,Q7L590 2 +Dolichocephaly 0.2607759587629077 0.0201562000783219 0.9839187680538796 1.0 1.0 29 Q96J02,P50542,P21281,P27635 4 +Hypoplastic ilia 0.2623860083302038 0.0198955597629491 0.984126687241144 1.0 1.0 8 Q09472 1 +Calvarial skull defect 0.2612864837867612 0.0184563047418003 0.9852748353866518 1.0 1.0 8 Q14739,Q13363 2 +Vaginal fistula 0.2627769699246162 0.0178784340730744 0.9857358333817208 1.0 1.0 7 P16435 1 +Abnormal myocardium morphology 0.339650475424287 0.0136284242087229 0.9891264273354236 1.0 1.0 158 Q9Y5P6,Q9Y6M9,Q7L590,Q14108,P08236,Q96AX1,P00846,Q96CU9,Q9Y3Z3,P16278,Q86Y39,P03886,P00403,P54802,Q96IX5,P23786,P49748,O00170,Q9NZ08,P10253,Q15233,P04062,P53701,Q9NPL8,P50542,O43772,P15586,Q9Y223 28 +Dysarthria 0.328898212475145 0.0134864949618238 0.9892396600833212 1.0 1.0 145 Q14108,O75503,Q13315,P00846,Q9Y4P8,Q96CU9,Q8N2K0,P04350,O15118,P07737,Q8TD30,O43681,P51648,Q8IV08,Q08J23,P35270,Q8TB37,Q9H6K4,Q13509,Q96T60,P07602,Q15233,P04062,Q9NZJ7,O14773,Q96RR1,P15586 27 +Bilateral single transverse palmar creases 0.2580975428132113 0.0134854368019198 0.9892405042959992 1.0 1.0 12 P50542,Q6DKJ4 2 +Melanocytic nevus 0.2571117670217732 0.0114431798049209 0.9908698627673096 1.0 1.0 12 Q96AY3,Q15022,P19447 3 +Neoplasm of the oral cavity 0.2555464409918802 0.0113043243463944 0.9909806462279322 1.0 1.0 8 P43246,Q8NCM8,P52701 3 +Recurrent fractures 0.2570838872544781 0.0106883181309443 0.9914721183537512 1.0 1.0 28 Q13126,Q96AY3,P16435 3 +Abnormal uvula morphology 0.2674826707270744 0.0098143095031933 0.9921694396801336 1.0 1.0 39 Q15436,Q6PGP7,P48651,P21281,P78318,Q15392,Q9Y619,P62266,Q6DKJ4 9 +Mixed hearing impairment 0.2065649867374005 0.0089576266470977 0.9928529435758384 1.0 1.0 5 P78318,O75369,Q9NWM8,P21333 4 +Clubbing 0.2584221352733452 0.0085547626311802 0.9931743702297896 1.0 1.0 14 P50851,Q9H4L7,Q96AX1 3 +Abnormality of the peripheral nervous system 0.2821656809012781 0.0064695547146455 0.9948380781867652 1.0 1.0 95 Q99720,Q09472,Q15120,Q8N2K0,Q9NR77,O43681,O15269,P06280,Q9Y6X9,Q13509,Q96T60,P07602,P04062,Q92766,Q6PJG6,Q9NZJ7,P42892,O14802,P19447,Q92890,Q96EK5,Q9Y619,Q96RR1 23 +Impaired glucose tolerance 0.2337011945012757 0.0055998590151588 0.9955319823008076 1.0 1.0 6 O00170 1 +Broad forehead 0.2610634378003761 0.0043171306538582 0.9965554388040564 1.0 1.0 32 Q6PGP7,P48651,P27635,Q15022,O14802,Q13045,Q07864,P78318,Q8NCH0,O00170 10 +Increased mean corpuscular volume 0.2566393550324589 0.0040834150590297 0.9967419152234216 1.0 1.0 20 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Abnormal pancreas size 0.2275290215588692 0.0021155050964672 0.9983120724042436 1.0 1.0 6 Q7Z2Z2,O00330,A5YKK6,Q9Y3E5,Q9Y3A5 5 +2 3 toe syndactyly 0.2579925399279653 0.0019847567474707 0.9984163942739496 1.0 1.0 30 Q9Y5P4,Q9Y223 2 +Abnormality of the abdominal wall 0.3035479511111343 0.0018444046144628 0.9985283788686136 1.0 1.0 118 Q9UBM7,Q8NCM8,Q15022,Q6UX04,P49711,P63000,P08236,Q9Y487,Q96HY6,Q14739,P27635,P16278,P04066,P07437,Q15056,Q32P28,P43034,O75844,Q6PGP7,P48651,P42345,Q15427,Q96DF8,P26196,O15111,P56377,Q6DKJ4,Q96T60,Q92766,Q6PJG6,Q69YQ0,P19447,Q9UHX1,Q8NCH0,Q92890,Q9Y223 36 +Echolalia 0.2449951903323244 0.0014882155505435 0.9988125762273894 1.0 1.0 7 P53701 1 +Oral cleft 0.3322698256345233 0.0002870152189897 0.9997709949911968 1.0 1.0 151 Q9UBM7,Q8NCM8,Q13363,Q9Y5P6,P49711,Q13045,Q8TAA9,Q14739,O95630,P49454,P16435,P07437,P62244,P29372,P63241,P62266,O75844,Q8IWS0,Q6PGP7,P48651,Q8WWQ0,Q96DF8,Q08J23,Q9Y4R8,P61313,O15111,P18077,Q8NCH0,Q6DKJ4,Q96T60,Q15436,Q15233,Q92766,Q69YQ0,P61254,O14802,O43684,P21281,P08708,P50542,P78318,Q9UHX1,Q15392,Q9H3P2,Q92890,Q96EK5,Q9Y619,Q7LGA3 48 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..78be5ffc109904807dd808549f6843a42caa4378 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil count", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal haptoglobin level", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemidiaphragm morphology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the dental root", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of cytokine secretion", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of olfactory lobe morphology", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the 2nd finger", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of tumor necrosis factor secretion", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of venous physiology", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality of von willebrand factor", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 2nd finger", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the 2nd finger", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonate wasting renal tubular acidosis", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Budd chiari syndrome", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of cartilage", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical cord compression", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clinodactyly of the 2nd finger", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Compensatory head posture", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Conjunctival icterus", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery aneurysm", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duodenal ulcer", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg myotonic discharges", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemolytic uremic syndrome", "Hemophagocytosis", "Hemoptysis", "Hemorrhage of the eye", "Hemothorax", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermagnesiuria", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypoautofluorescent retinal lesion", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Imbalanced hemoglobin synthesis", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating interleukin 6", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urinary potassium", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the 5th finger", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens luxation", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lipemia retinalis", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphadenitis", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary cystadenoma of the epididymis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Popliteal pterygium", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior helix pit", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posterior uveitis", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Remnants of the hyaloid vascular system", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal sodium wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal flecks", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Silver gray hair", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skewfoot", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small pituitary gland", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hematomas", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary cusp", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supernumerary vertebrae", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ANAPC1", "ANAPC2", "ANK3", "ANKFY1", "ANKLE2", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP1S2", "AP2M1", "AP3B1", "AP3D1", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARL2", "ARL3", "ARVCF", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATM", "ATP11C", "ATP1A1", "ATP2A2", "ATP2B4", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATRX", "ATXN10", "ATXN2", "B4GALT1", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDK", "BCL10", "BCOR", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1B", "BUB3", "C12orf57", "C19orf70", "C1QBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAPN1", "CARS", "CASK", "CAST", "CBL", "CC2D1A", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC40", "CDC42", "CDC6", "CDC73", "CDH2", "CDK13", "CDK4", "CDK5", "CDK6", "CELF2", "CENPF", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHEK2", "CHMP1A", "CHORDC1", "CHP1", "CHST14", "CHUK", "CISD2", "CIZ1", "CLASP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNOT1", "CNOT2", "CNP", "COA3", "COA7", "COASY", "COG1", "COG8", "COL4A3BP", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COQ9", "COX14", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CWC27", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "DARS", "DARS2", "DAXX", "DBT", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DICER1", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJB11", "DNAJC13", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL5", "DSC2", "DSG2", "DSP", "DYNC1H1", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHHADH", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EP300", "EPB41", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXT2", "EZR", "FAH", "FAM50A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNA11", "GNAI2", "GNAI3", "GNE", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIRA", "HIST1H1E", "HK1", "HLA-A", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IGF2R", "IKBKB", "INF2", "INTS1", "IRS4", "ITCH", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "KNL1", "L2HGDH", "LAMB1", "LAMP2", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD3", "LETM1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRIG2", "LRPAP1", "LRPPRC", "LRRC8A", "LRSAM1", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAN2B1", "MAP1B", "MAP2K1", "MAPK1", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED12", "MED17", "MED23", "MESD", "MFN2", "MGME1", "MIA3", "MICU1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMACHC", "MOGS", "MORC2", "MPG", "MPI", "MPP5", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVK", "MYH14", "MYH9", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEFL", "NEK9", "NELFA", "NEMF", "NFS1", "NFU1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPM1", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NTHL1", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OTULIN", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDHA1", "PDHB", "PDHX", "PDK3", "PDXK", "PEPD", "PEX14", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PISD", "PITRM1", "PKP2", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRKG1", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QRSL1", "RAB18", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBMX", "RDH11", "RDX", "REEP6", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RNASEH2A", "RNASET2", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS23", "RPS24", "RPS6KA3", "RPS7", "RPSA", "RREB1", "RRP7A", "SAMHD1", "SARS", "SARS2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINH1", "SETD2", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC37A4", "SLTM", "SMARCA4", "SMARCAD1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SRC", "SRCAP", "SRP54", "SRP72", "SRSF2", "SSBP1", "SSR4", "STAG1", "STAG2", "STAMBP", "STAT1", "STK4", "STT3A", "STT3B", "STUB1", "STX3", "STXBP2", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TACO1", "TAF15", "TAF6", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBL2", "TCF20", "TCOF1", "TECR", "TELO2", "TERF2IP", "TFAM", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TIMMDC1", "TJP2", "TKT", "TLK2", "TMCO1", "TMEM43", "TMEM70", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOMM40", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM3", "TPP1", "TPP2", "TRAPPC11", "TRAPPC4", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TSR2", "TTC19", "TTC37", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWNK", "TXN2", "TXNL4A", "UBA1", "UBE4A", "UBE4B", "UBTF", "UFC1", "UFD1", "UFSP2", "UGDH", "UGP2", "UMPS", "UNC45A", "UPF3B", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP7", "USP8", "USP9X", "VAMP7", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VIPAS39", "VPS13C", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS53", "VRK1", "WARS", "WASHC4", "WASHC5", "WBP11", "WDR1", "WDR36", "WDR62", "WFS1", "WIPI2", "XPNPEP3", "XRCC1", "YARS", "YARS2", "YME1L1", "YWHAE", "ZC3H14", "ZCCHC8", "ZFR", "ZFYVE26", "ZMPSTE24", "ZNF148", "ZNF687", "ZPR1"], "leading_proteins": ["ABCB1", "ABHD12", "ACAD9", "ACADVL", "ACAT2", "ADD1", "ADD3", "ADK", "AGL", "AGPS", "AHCY", "AIMP1", "AIMP2", "AIP", "ALDH18A1", "ALDH3A2", "ALDH6A1", "ALDOA", "ALG1", "ALG11", "ANAPC1", "ANK3", "ANKLE2", "ANO6", "AP1B1", "AP1S2", "AP2M1", "AP3B1", "APP", "APRT", "ARL3", "ARVCF", "ASAH1", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Pathogenic escherichia coli infection 6 24 3.240621548893338 0.0011926941213447 8.04368932038835 23.04126213592233 -0.1828642907559088 0.5748742925026463 4.5754764175075255 2.330828920267767 0.9569379411043492 0.3191018272971252 3.60354480543106e-05 5.591060906738053e-05 2.054752948225633e-07 9.536310572418432e-05 0.0002699095083601 +Lysosome 23 46 3.1903166139448844 0.001421170040242 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 0.0007719620465837 9.590098126685308e-05 0.0003686013375332 1.9689035836812974e-10 3.887743937181315e-11 +Gap junction 6 20 3.141784023083676 0.0016792185324008 6.849514563106796 16.725728155339805 0.1092386662992923 0.5937456832302471 4.017760903410304 2.3953875993966403 0.9524162344483764 0.3203538229624096 0.0001201862708332 0.000185314654978 1.742791115894586e-06 0.0006589165548416 0.0283917079041131 +Glycerophospholipid metabolism 2 15 2.3483814427276277 0.0188552007498787 5.553398058252427 16.104368932038835 0.8448777148315795 0.3373638196000335 3.045697762577092 2.514285464673758 1.2272389207362138 0.3056726473181033 0.0216431235145122 0.0265864003984115 0.0949012099695084 0.1435696883620607 0.1224012932705566 +Porphyrin and chlorophyll metabolism 4 13 2.34170887838557 0.0191956813385194 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.0031456664429394 0.0039064712270754 0.0155240337321844 0.0012174977382918 0.0022923961599421 +Ribosome 43 68 2.223708480122592 0.0261680643134787 37.58980582524272 71.83252427184466 -1.1465156070967828 0.3112763158975234 13.159558265713326 1.6746570252811466 2.1898923040449123 0.3742528198975103 1.0 1.0 1.0 0.6100792318639108 4.966086491830454e-05 +Riboflavin metabolism 2 5 2.099744761934579 0.0357512997196507 1.2597087378640777 5.470873786407767 0.8651682051380694 0.3242718261444057 1.1073575266667028 1.2430881579904736 0.9666566709677474 0.2578857718572043 0.0454466093947272 0.0506073598520519 0.1008375048293403 0.2373820829012167 0.0142438301551866 +Calcium signaling pathway 1 16 2.086311156913572 0.0369504466987331 5.735436893203883 16.946601941747574 1.0005800740695592 0.3113014190776675 2.984654368989517 2.3866666657890168 1.2450167285670062 0.3187454651207294 0.0305573199428786 0.037406554204333 0.1290920553826253 0.4718272431262216 0.8335370210894861 +Terpenoid backbone biosynthesis 0 8 1.9788283882788011 0.0478353311260246 3.0024271844660193 8.95388349514563 -0.3613047319900617 0.492161273328121 1.828175899218756 1.7681951376132234 0.891907503584582 0.2753761890155874 0.0574868878492186 0.0639684350193291 0.1265462710440741 0.2917500038862815 0.5041689495301098 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0c747f3a6528ccd1da7597f34775a63ea9d23ef0 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 179, + "title": "Average number of proteins per term", + "value": 15.458100558659218 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2f55636616ff35d00c6b4fa65f7aad19693b13cc --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8443432f41336df476375dcd5396ad7cd192b86e --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,62 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Pathogenic escherichia coli infection 0.7488195665477883 3.240621548893338 0.0011926941213447 0.1923444933392545 0.1001933724332494 24 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Lysosome 0.6620227600903881 3.1903166139448844 0.001421170040242 0.2247505062174301 0.1001933724332494 46 Q8NCC3,Q14108,O75503,P11117,P08236,Q9Y487,P10619,P16278,P04066,O15118,O43681,P50897,Q93050,P54802,Q13510,P07602,P10253,P20645,P04062,Q9NZJ7,Q92572,O14773,P15586 23 +Gap junction 0.8019999935636629 3.1417840230836753 0.0016792185324008 0.259798453720906 0.1001933724332494 20 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Glycerophospholipid metabolism 0.7146507432937578 2.3483814427276273 0.0188552007498787 0.966869652021789 0.448610842223865 15 P35790,Q8NCC3 2 +Porphyrin and chlorophyll metabolism 0.7385291495595512 2.34170887838557 0.0191956813385194 0.9688653396180592 0.448610842223865 13 P30519,P09601,P08236,P22830 4 +Ribosome 0.4712977029807671 2.223708480122592 0.0261680643134787 0.9913176305859126 0.448610842223865 68 Q9Y3U8,P15880,Q9BYD1,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 43 +Riboflavin metabolism 0.8548732445236957 2.099744761934579 0.0357512997196507 0.9985214292016552 0.448610842223865 5 Q9NPH0,Q9Y217 2 +Calcium signaling pathway 0.6555627760601717 2.0863111569135717 0.0369504466987331 0.9988166709937129 0.448610842223865 16 P21796 1 +Renin angiotensin system 0.8925613053547279 1.9130253891764504 0.0557448022314077 0.9999652464030708 0.5251747157590521 4 Q9UIQ6,P10619 2 +Sphingolipid metabolism 0.649692294043291 1.840331649585318 0.0657195614946777 0.9999948068746372 0.5431042903432777 12 P04062,O43681,P16278,O95470,Q16880,Q16739,O15269,Q13510 8 +Galactose metabolism 0.6002939907381171 1.6839857609117392 0.0921844206152486 0.99999996969069 0.5431042903432777 14 P16278 1 +Parkinsons disease 0.4503471328546413 1.6737323133709203 0.0941832201641394 0.9999999795720534 0.5431042903432777 52 O14949,P21796,P45880,Q9Y6M9,P14406,P03886,P00846,Q9UDW1 8 +P53 signaling pathway 0.6115002955314729 1.643765288330992 0.1002246940156577 0.999999993834071 0.5431042903432777 12 P11802,O14757,P06493,Q13315,Q00534 5 +Glycosaminoglycan degradation 0.7113289149298622 1.629725742613347 0.1031594741434158 0.9999999965642212 0.5431042903432777 6 P16278,P54802,P08236 3 +Notch signaling pathway 0.6644229802389836 1.4429388717685434 0.1490376917566753 0.9999999999997156 0.699475388189111 7 P56545,Q09472,Q13363 3 +Cardiac muscle contraction 0.5097230396076659 1.3887723651509956 0.164901981069061 0.9999999999999902 0.699475388189111 19 P00403,O14949,Q9UDW1,P14406 4 +Base excision repair 0.5317437209478241 1.3551856301606524 0.1753584218087072 0.999999999999999 0.699475388189111 15 Q9NRF9,P28340,Q9UGN5,P12004,P09429,P29372 6 +Proteasome 0.4576088532911883 1.3536572027437703 0.1758457679805027 0.9999999999999992 0.699475388189111 32 P60900,P49720,P49721,P28070 4 +Other glycan degradation 0.6335634169540686 1.3056744498845687 0.1916632903211987 1.0 0.7429223763684627 7 P16278,P04066,P04062 3 +Metabolism of xenobiotics by cytochrome p450 0.6044029808050149 1.2878030419222022 0.1978145331318801 1.0 0.7429223763684627 8 P78417 1 +Biosynthesis of unsaturated fatty acids 0.5714229048670791 1.249032073325118 0.2116533431093357 1.0 0.7429223763684627 9 O95864,Q9NZ01 2 +Starch and sucrose metabolism 0.5056392116926183 1.1224072955404412 0.2616893039396875 1.0 0.8498578768845433 13 P10253,P08236,P35573 3 +Huntingtons disease 0.372249933965564 1.112606832778715 0.2658773246119241 1.0 0.8498578768845433 74 O14949,P21796,Q09472,P45880,Q9Y6M9,O15514,P14406,O14548,P00403,Q15334,P00846,P30876,Q9UDW1,P42858 14 +Vibrio cholerae infection 0.4547421367094592 1.0073814315730991 0.3137515109555773 1.0 0.9058309751781988 18 Q93050,P24390,P21281 3 +Cysteine and methionine metabolism 0.4664000484049046 0.9832486520832046 0.3254850750991516 1.0 0.9122896276354464 15 Q13126 1 +Inositol phosphate metabolism 0.4798081681143403 0.9168247705146644 0.3592344702969656 1.0 0.9122896276354464 11 O00443,Q02252 2 +Oxidative phosphorylation 0.3456447530725695 0.8632610121730083 0.3879939750525767 1.0 0.9122896276354464 58 O14949,Q93050,Q9Y6M9,Q86Y39,P14406,O14548,P03886,P00403,P21281,P00846,O75964,Q9UDW1 12 +Pantothenate and coa biosynthesis 0.7745739020569665 0.8216249850518732 0.4112903648427335 1.0 0.9122896276354464 3 O15382 1 +Mismatch repair 0.4218283706988425 0.8080426539240442 0.4190660280459735 1.0 0.9122896276354464 18 Q9UQ84,P28340,P12004,P40938,P52701,P15927 6 +Steroid biosynthesis 0.4518818203377281 0.7491808588692497 0.4537482043886003 1.0 0.9122896276354464 10 Q15800,Q16850,Q15392 3 +Chronic myeloid leukemia 0.4195744160039285 0.741000546648272 0.4586931088669843 1.0 0.9122896276354464 16 P11802,O15111,Q13363,Q00534 4 +Phosphatidylinositol signaling system 0.4664843778765976 0.6554611412237593 0.5121708973890651 1.0 0.9523749328503326 8 O00443 1 +Cell adhesion molecules cams 0.4209649937714937 0.6197896090186156 0.5353963106445558 1.0 0.9564327846288624 11 Q16625,P10586,Q92896,Q9BY67 4 +Wnt signaling pathway 0.3563320414178101 0.6039449167334703 0.5458802646881773 1.0 0.9564327846288624 27 Q13362,Q8TAA9 2 +Sulfur metabolism 0.7032129844319384 0.5840112199108373 0.5592127633993791 1.0 0.9564327846288624 2 O43252 1 +Non small cell lung cancer 0.4301006044517579 0.5760933107227272 0.5645521126286592 1.0 0.9564327846288624 9 P11802 1 +Melanoma 0.4478861878799824 0.5752462557041298 0.565124763612149 1.0 0.9564327846288624 8 P11802 1 +Pancreatic cancer 0.3851857823288641 0.4674251350308634 0.6401957430697289 1.0 1.0 12 P11802,P63000,O15111,Q00534 4 +Retinol metabolism 0.5126458035953888 0.4602333399232432 0.6453487426246842 1.0 1.0 4 Q6NUM9 1 +Renal cell carcinoma 0.3734197716363285 0.4496564112425725 0.652958205746673 1.0 1.0 14 Q09472,P27361,P63000,P62993,Q13617 5 +Glioma 0.3802981728417633 0.4284443679898012 0.668327628336207 1.0 1.0 11 P11802,Q00534 2 +Dna replication 0.3286047107855032 0.4152455856702974 0.6779621308277102 1.0 1.0 27 P49736,Q9NRF9,P28340,P27694,P49643,P33992,P12004,Q07864,P40938,Q14566,P09884,P35244,P15927 13 +Protein export 0.3699665587977935 0.4136286232262346 0.6791461075250793 1.0 1.0 13 Q15005,Q9Y5M8,P49458,P67812 4 +Ether lipid metabolism 0.434706627153473 0.3863594476181063 0.699230478972096 1.0 1.0 5 P43034,Q15102 2 +Fatty acid metabolism 0.3268420714828969 0.3853697078399806 0.6999635223909921 1.0 1.0 31 Q9BWD1,P23786 2 +Cytokine cytokine receptor interaction 0.6266975819807978 0.3552190611320994 0.7224254859664028 1.0 1.0 2 Q9NWH9 1 +Ubiquitin mediated proteolysis 0.3185266398394157 0.3414521244014684 0.7327632406230733 1.0 1.0 43 Q96J02,P30260,Q8TBC4,Q13042,Q13356,Q13309,Q15386,P29372,Q9UBE0,Q13617 10 +Selenoamino acid metabolism 0.3538366133882595 0.3050937604124428 0.7602947432725129 1.0 1.0 10 O43865 1 +Nucleotide excision repair 0.3029257872563987 0.2483487262685713 0.8038646014804991 1.0 1.0 23 Q9NRF9,P28340,P12004,P19447,P40938,P32780,P15927 7 +Glutathione metabolism 0.3029408195750475 0.1771473603964991 0.8593926419310656 1.0 1.0 19 P78417,P00390 2 +Vasopressin regulated water reabsorption 0.3037893098552509 0.1459170268885349 0.8839868899440688 1.0 1.0 14 P63167,Q8NCM8,Q9UJW0,P52565 4 +Pentose phosphate pathway 0.3054170820870767 0.1412297892819346 0.8876884134805616 1.0 1.0 12 P52209,Q96G03,P06744,P08237,P04075,P17858,Q01813,P11413,P29401,O95336,P36871 11 +Adherens junction 0.2751649675131057 0.1242938279193652 0.901082634014492 1.0 1.0 24 P10586,Q9UQB8 2 +Allograft rejection 0.4789665452136585 0.0951496629877448 0.924195951620702 1.0 1.0 2 P49327 1 +Autoimmune thyroid disease 0.4789665452136585 0.0951496629877448 0.924195951620702 1.0 1.0 2 P49327 1 +Graft versus host disease 0.4789665452136585 0.0951496629877448 0.924195951620702 1.0 1.0 2 P49327 1 +Steroid hormone biosynthesis 0.4607485922491017 0.0804501422467472 0.9358792483614928 1.0 1.0 2 Q53GQ0 1 +Hedgehog signaling pathway 0.394300861497674 0.0471872131881175 0.9623640185681676 1.0 1.0 3 P48729,Q9ULC3 2 +Aldosterone regulated sodium reabsorption 0.2774853543030293 0.0450104191456194 0.964099004095174 1.0 1.0 6 P27361,P05026,O14654 3 +Nitrogen metabolism 0.2635067948292923 0.0290756802941046 0.9768042319096408 1.0 1.0 4 P00367,P08243,P32929 3 +Rna polymerase 0.2526003784551884 0.0024197395560701 0.9980693290511058 1.0 1.0 12 O15514,P30876 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7c8a182c1b58e61e9555b96a6b632c75338b601e --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTN1", "ACTN4", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "APP", "APRT", "AQR", "ARF6", "ARFGAP1", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG4B", "ATIC", "ATM", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATRX", "B4GALT1", "B4GAT1", "BAIAP2", "BCAS2", "BCAT2", "BCL10", "BIRC6", "BLVRA", "BPNT1", "BUB1B", "BUB3", "BUD31", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CASK", "CASP7", "CBL", "CBR1", "CCDC12", "CCDC6", "CCNB1", "CCNB2", "CDC16", "CDC23", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDC6", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CETN2", "CFL1", "CFL2", "CHD8", 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platelet production 5 47 2.834816021077733 0.0045852083013957 12.805825242718448 44.49271844660194 -0.1851230754516618 0.703414804631471 6.829132700803817 4.981757535652317 0.6447331520495331 0.2863813279221834 0.0014391373822246 0.0021714502363067 0.0008957475254315 0.0656640386862375 0.2124650855836428 +Assembly and cell surface presentation of nmda receptors 5 11 2.818226587417104 0.0048289718504537 4.021844660194175 10.050970873786408 0.6119431771279947 0.4638365400303644 2.466672711798564 1.7830986526204615 1.029606868598912 0.3372268056856337 5.216543828348878e-06 8.147714785824873e-06 2.145557710414368e-07 4.683808949698386e-05 3.998190987032918e-05 +Recycling pathway of l1 5 21 2.7903188452437715 0.0052656157850432 6.898058252427185 21.32281553398058 -0.3135781567418741 0.5490472935437266 4.33088884310876 1.666390738148133 0.965013432779371 0.3357087870369806 2.479448605362093e-05 3.852992678051272e-05 2.315265013843182e-06 0.000429077277481 0.0033654671202252 +Golgi to er retrograde transport 7 70 2.777535089416958 0.0054772925673582 16.92233009708738 70.53883495145631 0.4559805501598206 0.6345143601474961 7.275693434924061 5.280109829133333 0.9044409230983104 0.3556018909943214 0.0001143756559843 0.0001945343448514 1.3871254672632278e-05 0.006917220356641 0.0004576674664181 +Mitotic g2 g2 m phases 13 82 2.7330194054706403 0.006275663473781 25.512135922330096 89.70388349514563 0.5564324413272281 0.5721896286221594 11.374146646790262 7.343161700072858 1.2377579618165189 0.3831596446417351 0.0075978549160718 0.0111666787722125 0.00040944578563 0.0001755715325218 0.0002870436143322 +Transport of connexons to the plasma membrane 5 6 2.7034421186753583 0.0068625398943682 2.7063106796116503 4.587378640776699 0.4995785603281155 0.4095483585324659 1.3523295185638555 0.9949561742458796 1.150433862709782 0.3070287716914409 2.662071008957814e-07 4.180795645578565e-07 1.906490679947712e-09 4.971597541903914e-07 2.8278124161204832e-05 +Gap junction assembly 5 6 2.7034421186753583 0.0068625398943682 2.7184466019417477 4.604368932038835 0.499967666973865 0.4121155936503509 1.37358913126072 1.0102774490620512 1.1493312724073153 0.3091304616480874 3.618989489062174e-07 5.681407678506709e-07 3.152910227260874e-09 8.117802851328154e-07 4.519283976440595e-05 +Activation of ampk downstream of nmdars 5 8 2.70066378079757 0.0069201255639397 3.354368932038835 6.451456310679611 0.5566970459139938 0.4440483464816752 1.771033196282823 1.4598419968812493 1.088746190595968 0.3283169353723064 1.557882981353644e-06 2.4399455571500253e-06 3.2628266642109166e-08 7.783558439777885e-06 0.0003811967334318 +Activation of nmda receptors and postsynaptic events 5 24 2.687526962713461 0.0071983290523189 6.531553398058253 22.640776699029125 0.202717901626862 0.5678584679324417 3.686958716509548 3.4007548246413095 0.9825513888915872 0.3302803464124077 0.0001835871077682 0.0002823024527817 4.573392792239334e-05 0.0060584295805293 0.0172408232976174 +Glycerophospholipid biosynthesis 4 27 2.673886685020583 0.0074977781232909 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 0.005606303644163 0.0076236623955354 0.0093429514575269 0.0582090778653858 0.0240666423912158 +Carboxyterminal post translational modifications of tubulin 5 7 2.664662641153856 0.0077065590626608 3.2111650485436893 5.764563106796117 0.4532219515804401 0.4130550911105556 1.6044754161745491 1.1192952677926271 1.149295682796638 0.3146953714506392 3.252668670762926e-06 5.086318889591563e-06 1.0323398105951234e-07 2.340849497796301e-05 0.0010532104032369 +Protein localization 14 69 2.6258165687083084 0.0086441386466169 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 0.0003070389306621 0.0005165575391543 6.361576956114066e-05 8.830598184191495e-06 0.0001841429516671 +Er to golgi anterograde transport 13 68 2.602468457349336 0.0092555328837578 19.152912621359224 74.15776699029126 0.4357486981835305 0.6456866134420882 7.637631429097237 6.107600140782552 0.9360192475456132 0.3613336360589621 0.0001963789162647 0.0003321229022593 0.0002347229462285 0.0378996247633401 0.004101781867588 +Pink1 prkn mediated mitophagy 2 9 2.5885011818821693 0.0096394616218531 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.002269766977186 0.0028214739728005 0.0113213926532688 0.0075105395483816 0.0472723399635447 +Ub specific processing proteases 9 64 2.586948757500536 0.0096829990970119 17.070388349514563 72.1116504854369 0.5586830572298067 0.5701992170768696 9.734454714417684 6.256038651254875 1.0924507106168106 0.3735968680377643 0.1329712843973368 0.1585734488003576 0.1773476378037675 0.0037747824878373 0.0069140384424972 +Sphingolipid metabolism 16 27 2.5214870288266966 0.0116859983838193 11.00242718446602 26.135922330097088 1.1708540815039898 0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 0.0280016517596001 0.0343104139968933 0.0029226642017144 1.6974009404024902e-05 1.2235470868051011e-06 +Nuclear envelope ne reassembly 8 46 2.51303290901158 0.0119698168464601 12.87621359223301 48.432038834951456 0.3029395053279946 0.6511236784131957 5.145147325677084 2.769063267087378 0.8345402449033724 0.3415462759835261 0.0002170371637356 0.0003333499341555 5.847139580153321e-05 5.151071205907272e-05 0.0006038449354666 +Mitochondrial protein import 9 33 2.487741665066177 0.0128557077825284 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 0.0001054611075806 0.0001627366612638 0.0002457945313068 1.120343948585762e-05 0.0005113372584308 +Phospholipid metabolism 11 41 2.470469160162239 0.0134935953203727 12.859223300970871 45.932038834951456 1.017004520648936 0.3949296504793965 6.241466981115118 7.362344677079641 1.3242274243570669 0.3709328103546776 0.0277474709880321 0.0368119012096574 0.0632048376565007 0.0862469664528994 0.0796125915144056 +Transport to the golgi and subsequent modification 14 71 2.453107594566054 0.0141627969214002 20.604368932038835 77.1626213592233 0.4958457957496105 0.6299790557050085 8.044251420264837 7.0373663516482345 0.9638132242129624 0.3700222187340509 0.00037173136122 0.0006238845233921 0.0005411829706675 0.0693781675257684 0.0023185186552482 +Rho gtpases activate formins 13 56 2.4468379699546725 0.0144115610778425 16.099514563106798 59.842233009708735 -0.2306109922766472 0.6830657091738281 7.582382477572316 6.754492418324387 0.727097409785596 0.309229846466411 0.0002264860267111 0.0003824228040307 0.0002831699450166 0.0158285055444122 0.0020734320957393 +Resolution of sister chromatid cohesion 6 59 2.3951084108176905 0.0166154517355046 16.339805825242717 61.6626213592233 -0.1457131535358655 0.7072886317098008 6.882937110221699 6.719429943049022 0.6353792619034297 0.2845641341490769 0.0001398346739826 0.0002373552777034 0.0001498589333904 0.0088650438222446 0.0020985212670913 +Mitophagy 2 13 2.349161837448539 0.0188157266602675 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.004520933605864 0.0056070915236824 0.0219975904219434 0.0197332243190265 0.1098061730973064 +Hcmv infection 7 52 2.336511462128338 0.0194646009232355 14.00485436893204 52.817961165048544 -0.2385386853821961 0.6894872485949345 6.684279174719419 4.338623972998164 0.6896725732682144 0.2915139648437624 0.0008635231874609 0.0013104772577149 0.0004328336841006 0.0033544931105218 0.0108382395185211 +Sialic acid metabolism 2 5 2.319262182781068 0.0203808246208332 1.633495145631068 4.638349514563107 0.3331729503932819 0.3039098658637086 1.1012545438565893 0.8492059078669172 1.3430882059420008 0.2726683810004117 0.0020080999837554 0.0024970154667983 0.0100519320580488 0.0062969264366488 0.0403506671570748 +Mitochondrial calcium ion transport 2 17 2.315746759216845 0.0205720997216793 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 0.0034675113283986 0.0043047615253927 0.0010099703116007 0.0136772183990335 0.0173495207202435 +Heparan sulfate heparin hs gag metabolism 3 5 2.2995253841716243 0.0214751236448429 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 0.1266743042911767 0.1403531442218371 0.266209970857853 0.0071928662194731 0.0686432790956221 +Hcmv early events 6 43 2.2921354734412605 0.0218978269896692 12.46359223300971 44.35436893203884 -0.2344123619104917 0.6821756516237598 5.833959396627051 3.0514448813454176 0.7325989596008913 0.2957065288821427 0.0003275153966786 0.0005014755444469 0.0001066840361729 0.003025768786718 0.0145017950635795 +Platelet sensitization by ldl 0 6 2.280774509608165 0.0225617934944013 2.1990291262135924 5.449029126213592 0.1837475285624822 0.5280601302474661 1.4760873987878906 1.0770437917042883 0.908152314259454 0.297897263394418 0.0614672516091427 0.0683810764565047 0.1349531130589082 0.3090006421698555 0.5284199673110125 +Neurotransmitter receptors and postsynaptic signal transmission 5 34 2.275791035238328 0.0228585195613091 8.473300970873787 34.27669902912621 -0.1043666195156999 0.6608806410357011 4.520370911912118 4.554006107578594 0.7763252768262388 0.3048074379555449 0.0009625062467801 0.0014590049028022 0.000505494538773 0.0427349298488789 0.0707250005370495 +Gpcr ligand binding 3 9 2.235674138272193 0.0253731242834307 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 1.0 1.0 1.0 0.0250870181555185 0.1856866108969999 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 4 8 2.230729520738028 0.0256990509479615 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 0.0772251634861832 0.0858288536093336 0.014058804472369 0.0103266247469619 0.0017902696143218 +Intra golgi and retrograde golgi to er traffic 16 87 2.223500062339752 0.0261820991886201 23.762135922330096 91.83252427184466 0.7836914286379623 0.5449079285432085 8.961715947260837 10.213669235838784 1.1120768516172963 0.4008074869702365 0.0001017597176521 0.0001903287561044 5.809670081265907e-05 0.0129748789548342 0.0032192144650806 +Metabolism of porphyrins 1 8 2.211779941563748 0.0269818737182285 2.766990291262136 9.186893203883496 1.2638611374915407 0.2204767139400954 1.3861582272503026 1.170645435718008 1.0950295956895657 0.2541910601955712 0.002269766977186 0.0028214739728005 0.0113213926532688 0.0075105395483816 0.0472723399635447 +Glycosphingolipid metabolism 8 17 2.1917732722315697 0.0283958819504974 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 0.0084436709506226 0.0104419310742173 0.0398064357050217 0.0001243566118537 1.982341418686921e-05 +Eukaryotic translation elongation 45 73 2.189484801336031 0.0285616220391355 40.33980582524272 76.70873786407768 -1.170264854227122 0.3173586097479524 13.865899638243102 1.3501604935966776 2.213815111182405 0.3781772268307828 1.0 1.0 1.0 0.6415769423697447 5.327493367648088e-06 +Cholesterol biosynthesis 5 15 2.1736063614136096 0.0297347102694958 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 0.0965594926942356 0.1071891284628969 0.0219975904219434 0.0002379581347217 0.000834425134113 +Biological oxidations 11 42 2.1665179974373685 0.0302716260899755 9.58980582524272 42.907766990291265 0.5797258374932459 0.4965502516733612 4.863095917627343 3.5143586004975274 1.0031637620757048 0.3373734498260092 1.0 1.0 0.0002783591093982 0.0020097599472663 0.0001742153784976 +Peptide ligand binding receptors 3 7 2.147728098942866 0.0317353618037352 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 1.0 1.0 1.0 0.0006333985816127 0.0080495273899022 +Class a 1 rhodopsin like receptors 3 7 2.147728098942866 0.0317353618037352 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 1.0 1.0 1.0 0.0014755138450769 0.0173495207202435 +Diseases of carbohydrate metabolism 5 10 2.141029740929137 0.0322716397596354 3.5024271844660193 9.050970873786408 0.3053509571481614 0.2820635836848948 1.390848707873377 1.194576753712748 1.470873952821233 0.2708232247081553 0.0927245527266703 0.1029565435856987 0.1993869387044997 1.3899438578388623e-05 0.0006524167345181 +Deubiquitination 20 81 2.1352651052148586 0.0327393615400697 21.274271844660195 90.48543689320388 0.4172727973060445 0.5987827475213043 11.64961844468234 9.030277095459189 1.0784969503501256 0.3703499256790007 0.2388956093568305 0.2792677388815299 0.3573820216030455 0.0192059603965531 0.0118245150691509 +Transmission across chemical synapses 5 41 2.107489175732085 0.0350751989765252 10.08980582524272 41.75485436893204 -0.0875466460048407 0.6985207150385785 5.090843957076849 5.151642280154465 0.7606143516144942 0.3106830924252281 0.0027034105318834 0.0040448090727101 0.0021720795675268 0.1231360237841914 0.1419916911786224 +Iron uptake and transport 4 17 2.105374617908488 0.0352587114466915 4.089805825242719 17.9126213592233 1.0360420001787272 0.323786301352462 2.0477771422769826 0.9863810102632052 1.0014322629164618 0.2971986354372174 0.0110936370528411 0.0136970422924113 0.0513963234576887 0.013184387389335 0.0361785711536894 +Glycosaminoglycan metabolism 7 16 2.096186072014973 0.0360656879903189 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 0.256841405101423 0.2821140734917597 0.1454623761357323 0.0015047319226948 0.0067309962323406 +Response of eif2ak4 gcn2 to amino acid deficiency 44 72 2.07770341011141 0.0377366847775608 39.550970873786405 76.03155339805825 -1.127048342201767 0.3185079045659907 13.761485019110056 1.5173669435319213 2.220942857496925 0.3803423215749384 1.0 1.0 1.0 0.6710434870715313 0.0001742153784976 +Synthesis of substrates in n glycan biosythesis 4 15 2.068436167178696 0.0385990272307548 4.101941747572815 15.29126213592233 -0.0934295860101241 0.4651486832142111 2.554131645515961 2.6342813465607953 0.9880430361156176 0.2693319722460128 0.0146921641380013 0.0181053013145446 0.0666692325567911 0.0216647555097342 0.061872997913683 +Organelle biogenesis and maintenance 15 88 2.068071980212306 0.0386332550447579 25.364077669902912 93.59466019417476 0.8635708484684039 0.4952956395971041 8.486338013959335 9.495950625534562 1.0729913690397648 0.3929655478972317 0.0051429623265821 0.0015145859594756 4.983524571889533e-05 0.0008433189584311 0.0060965890938177 +Recruitment of mitotic centrosome proteins and complexes 7 27 2.0668555374252437 0.0387477684374124 10.75485436893204 32.21116504854369 0.6690475765725821 0.4763419930316802 4.776113780352103 4.3238525164960775 1.0085704741220791 0.3559421309914655 0.0466532871696867 0.0568079337981731 0.0442161560616649 0.0492274998504545 0.0462972106215003 +Cellular response to chemical stress 11 71 2.0346690360815183 0.0418841857990228 16.92233009708738 74.85436893203884 0.6393995551476427 0.564482392286313 7.443234134196828 3.8890130701767585 0.935566980068825 0.3664371412566685 0.10796343101818 0.1294383689627619 0.1360323291825775 0.0003899955689035 0.0002497324937721 +Neuronal system 10 51 2.034362852970524 0.0419150243147781 11.54368932038835 51.987864077669904 0.0486929618904988 0.6974675839636986 5.6082060178304465 5.891193715962907 0.7569879189317831 0.3101601096483197 0.006392512211159 0.0094271760484152 0.0070907800629845 0.0672621717828269 0.1568092989481765 +Platelet homeostasis 0 12 2.028977694444078 0.042460562282079 3.1966019417475726 10.74757281553398 0.2221712216446273 0.631004145190955 2.0151581177684 2.0690434289104025 0.7236227488581506 0.293178034111333 0.1943215284903705 0.2143583684675494 0.3896854720293997 0.7160479454809648 0.9227191737187296 +Nr1h2 and nr1h3 mediated signaling 2 5 2.0191756663077083 0.0434689645426074 1.7572815533980584 5.883495145631068 0.5602851963271924 0.4625468402768004 1.3326812116893596 1.0798325191407745 0.9054264155985514 0.3047539501790259 1.0 1.0 1.0 0.534424974066877 0.1913237113672655 +Phase ii conjugation of compounds 5 26 2.016317391523435 0.04376679746462 8.016990291262136 27.771844660194176 -0.0394450036762533 0.5856344148145399 4.678208381431926 2.844067833218331 0.9498421516045116 0.3223517668002427 1.0 1.0 0.0142561824639166 0.1379209656438769 0.013971578774249 +Aurka activation by tpx2 7 28 2.013125388652334 0.0441014399199228 10.276699029126211 31.893203883495147 0.5790832053921023 0.5039527741558584 4.914920890107843 4.281168113347361 0.9784215516709706 0.3534896123548716 0.0378022678730432 0.0461595615554375 0.033011066423499 0.0322116961133286 0.0254167175009885 +Transport of inorganic cations anions and amino acids oligopeptides 2 11 1.9654271763815003 0.0493648166433653 3.45873786407767 9.99514563106796 1.347451847228265 0.1988162564497566 2.1544143797408783 1.7967002462592632 1.0339867286779445 0.2465647399589519 1.0 1.0 0.3467918934582977 0.0909853548684221 0.1661443482772651 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..03fa88e761c3f4315150b1d8db54fdc0017eb651 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 1374, + "title": "Average number of proteins per term", + "value": 18.45633187772926 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f98c0764d8a9f8b6adfbb5881d345d7f847c332e --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a213eed26d5ee729b71c99d90ac93b2c68ba9458 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,481 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Signaling by hedgehog 0.6634082993758752 3.53164745242682 0.000412979543525 0.4330879457158888 0.1837002421863482 53 P60900,P49720,P28070,Q9BVA1,P04350,Q9GZP9,Q9BUF5,P49721,Q13509,P68371,Q13885 11 +The role of gtse1 in g2 m progression after g2 checkpoint 0.6935248851027539 3.4614106642601636 0.0005373524311489 0.5221797585419129 0.1837002421863482 47 P60900,P49720,P28070,Q9BVA1,P04350,Q9BUF5,P49721,Q13509,P68371,Q13885 10 +Hedgehog off state 0.6759258682444527 3.333338182480221 0.0008581057090397 0.6925809268421654 0.1837002421863482 47 P60900,P49720,P28070,Q9BVA1,P04350,Q9BUF5,P49721,Q13509,P68371,Q13885 10 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.8665761004396154 3.306042343529889 0.0009462378702014 0.7276715320457454 0.1837002421863482 18 Q9BVA1,P04350,Q9BUF5,P78371,P68371,Q13885 6 +Cilium assembly 0.6173655592829521 3.2758692476352635 0.0010533731598747 0.7649830287085787 0.1837002421863482 55 Q9H6D7,Q9BVA1,P04350,Q9BUF5,P78371,A6NIH7,P07437,Q13509,P68371,Q13885 10 +Translocation of slc2a4 glut4 to the plasma membrane 0.7265295454365062 3.2656218159565533 0.0010922401495878 0.777217238485693 0.1837002421863482 34 Q9BVA1,P04350,Q9UIQ6,Q9BUF5,P68371,Q13885 6 +Protein folding 0.7187730726193187 3.263071338191292 0.0011021177336763 0.7802236528373011 0.1837002421863482 36 Q9BVA1,P04350,Q9BUF5,P78371,Q13509,P68371,Q13885 7 +Formation of tubulin folding intermediates by cct tric 0.9165741858477364 3.2494384831352803 0.0011563308545581 0.7960168509658934 0.1837002421863482 14 Q9BVA1,P04350,Q9BUF5,P78371,P68371,Q13885 6 +Copi dependent golgi to er retrograde traffic 0.6587847311605374 3.2068672296005936 0.00134188912456 0.8419737029463283 0.1837002421863482 47 P24390,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 7 +Selective autophagy 0.7098274877176493 3.1807397075556483 0.0014689955258131 0.8673291215968391 0.1837002421863482 35 P21796,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885,Q9NS69 8 +Kinesins 0.7906994915916402 3.1705985069449136 0.001521252434784 0.8765343527078014 0.1837002421863482 21 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Autophagy 0.6286094624636198 3.155111292601825 0.0016043689273916 0.8898787379016961 0.1837002421863482 51 P21796,Q9BVA1,P04350,Q9BUF5,P50542,Q8N4H5,Q8WUX9,Q13509,P68371,Q13885,Q9NS69,Q7Z3C6 12 +Post chaperonin tubulin folding pathway 0.932189373169196 3.106074873647208 0.0018958870389453 0.9262755851578344 0.2003806762700741 11 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Gap junction trafficking and regulation 0.9022109587712692 3.041898119625319 0.0023509144965288 0.9605988151361424 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Recruitment of numa to mitotic centrosomes 0.6903497459260038 2.9928969652230246 0.002763430263841 0.9776785945545412 0.2280545450772817 32 Q9H6D7,Q9BVA1,P04350,Q9BUF5,P07437,Q13509,P68371,Q13885 8 +Copi independent golgi to er retrograde traffic 0.6921850374241817 2.9566316928988567 0.003110193828621 0.9861582472503764 0.2280545450772817 29 Q9UJW0,Q9BVA1,P04350,Q15042,Q9BUF5,Q15102,P43034,Q13509,P68371,Q13885 10 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.6831861480184835 2.9295257628884888 0.0033947967027936 0.9906500666586512 0.2280545450772817 31 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Aggrephagy 0.8183894586147685 2.927426864343867 0.0034177943349711 0.9909418721028296 0.2280545450772817 16 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Rho gtpases activate iqgaps 0.8753744083305596 2.922255911809014 0.0034750588234724 0.9916295390880596 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Cytoprotection by hmox1 0.5376169382760355 2.8850443951785674 0.0039135846899411 0.9954280482638612 0.2280545450772817 60 P30519,Q15648,P60900,P49720,P28070,P09601,P20618,P00403,P49721 9 +Copi mediated anterograde transport 0.5908708643108576 2.852917330547697 0.0043319889455293 0.997433167153744 0.2280545450772817 51 P24390,Q9BVA1,P04350,Q9BUF5,P68371,Q13885 6 +Intraflagellar transport 0.8594630941069132 2.8504593132467746 0.004365613535004 0.997549552148299 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Sealing of the nuclear envelope ne by escrt iii 0.9221199491708488 2.844738283540594 0.0044447926821431 0.9978032098237276 0.2280545450772817 9 Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 6 +Mhc class ii antigen presentation 0.5892759970822654 2.839931037581857 0.0045123287595798 0.9979987234378228 0.2280545450772817 51 Q9BVA1,P04350,Q9BUF5,P10619,P68371,Q13885 6 +Factors involved in megakaryocyte development and platelet production 0.6096952722652663 2.834816021077733 0.0045852083013957 0.9981902455223028 0.2280545450772817 47 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Assembly and cell surface presentation of nmda receptors 0.8664081339456998 2.818226587417104 0.0048289718504537 0.9987073736701634 0.2280545450772817 11 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Recycling pathway of l1 0.722013310281106 2.7903188452437715 0.0052656157850432 0.999292711186982 0.2280545450772817 21 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Golgi to er retrograde transport 0.5300731984112135 2.777535089416958 0.0054772925673582 0.999472037902612 0.2280545450772817 70 P24390,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 7 +Mitotic g2 g2 m phases 0.539257445879825 2.7330194054706403 0.006275663473781 0.9998248612643522 0.2463646175135763 82 Q9H6D7,P60900,P49720,P28070,Q9BVA1,P04350,Q7Z460,Q9BUF5,P07437,P49721,Q13509,P68371,Q13885 13 +Transport of connexons to the plasma membrane 0.9718076285240488 2.7034421186753583 0.0068625398943682 0.999922220487006 0.2472626029471571 6 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Gap junction assembly 0.9718076285240488 2.7034421186753583 0.0068625398943682 0.999922220487006 0.2472626029471571 6 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Activation of ampk downstream of nmdars 0.9260617457749049 2.70066378079757 0.0069201255639397 0.9999281768884029 0.2472626029471571 8 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Activation of nmda receptors and postsynaptic events 0.6576062235286207 2.687526962713461 0.0071983290523189 0.9999511264117824 0.2472626029471571 24 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Glycerophospholipid biosynthesis 0.6515629734960243 2.673886685020583 0.0074977781232909 0.9999677102959158 0.2512670034488252 27 Q9NPH0,P35790,Q8IV08,Q8NCC3 4 +Carboxyterminal post translational modifications of tubulin 0.9553539018080685 2.664662641153856 0.0077065590626608 0.9999758161294028 0.2521145750499041 7 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Protein localization 0.5131278893749105 2.6258165687083084 0.0086441386466169 0.999993401562452 0.2608713874371463 69 P46379,P21796,O60830,Q99595,Q13505,P09601,Q9NR77,Q5JRX3,P50542,Q8N4H5,P05067,Q9Y512,O14925,Q9NS69 14 +Er to golgi anterograde transport 0.5095383027643514 2.6024684573493357 0.0092555328837578 0.99999717307112 0.2608713874371463 68 P63167,Q9UJW0,Q15436,Q13509,P24390,Q9BVA1,Q12955,P04350,Q9BUF5,O14579,P49257,P68371,Q13885 13 +Pink1 prkn mediated mitophagy 0.8615406669096244 2.5885011818821693 0.0096394616218531 0.9999983402921884 0.2608713874371463 9 P21796,Q9NS69 2 +Ub specific processing proteases 0.5031555072800776 2.586948757500536 0.0096829990970119 0.9999984375775004 0.2608713874371463 64 Q96FW1,P21796,P45880,P49720,P60900,P28070,Q96K76,P20618,P49721 9 +Sphingolipid metabolism 0.6280453307271844 2.5214870288266966 0.0116859983838193 0.9999999032482708 0.2936880061970757 27 Q16739,P07602,P51648,P04062,Q9NZJ7,P16278,P22059,O95470,P10619,Q16880,O43681,O15269,Q96G23,Q9Y5P4,Q13510,P06280 16 +Nuclear envelope ne reassembly 0.5731417904845637 2.5130329090115797 0.0119698168464601 0.9999999347964486 0.2936880061970757 46 Q9BVA1,P04350,Q86XL3,Q9BUF5,Q9BTX1,Q13509,P68371,Q13885 8 +Mitochondrial protein import 0.6122182238837408 2.487741665066177 0.0128557077825284 0.999999980989322 0.3045472843654148 33 O60830,P21796,Q99595,Q13505,Q5JRX3,Q8N4H5,Q9Y512,O14925,Q9NS69 9 +Phospholipid metabolism 0.5869616754026117 2.470469160162239 0.0134935953203727 0.9999999921787676 0.3046382295531648 41 O00443,Q9Y217,Q8IV08,Q96N66,P35790,P48739,Q8NCC3,Q99943,Q9NPH0,Q8TBX8,Q8WUK0 11 +Transport to the golgi and subsequent modification 0.4978168419814317 2.453107594566054 0.0141627969214002 0.9999999969214276 0.3046382295531648 71 P63167,Q9UJW0,Q15436,Q13509,P24390,Q9BVA1,Q12955,P04350,P04066,Q9BUF5,O14579,P49257,P68371,Q13885 14 +Rho gtpases activate formins 0.515487994429746 2.4468379699546725 0.0144115610778425 0.9999999978235178 0.3046382295531648 56 P63167,Q9BVA1,Q13362,P04350,Q7Z460,P49454,Q9BUF5,P43034,Q13509,P68371,Q13257,Q13885,Q9P258 13 +Resolution of sister chromatid cohesion 0.4924082805941587 2.3951084108176905 0.0166154517355046 0.999999999899556 0.3170782039525462 59 Q9BVA1,Q13362,P04350,Q9BUF5,P68371,Q13885 6 +Mitophagy 0.7400413805736776 2.349161837448539 0.0188157266602675 0.999999999995373 0.3244353517787946 13 P21796,Q9NS69 2 +Hcmv infection 0.5242487057843181 2.336511462128338 0.0194646009232355 0.9999999999981356 0.3244353517787946 52 Q9BVA1,P04350,Q9BUF5,Q9BTX1,Q13509,P68371,Q13885 7 +Sialic acid metabolism 0.9099268853142212 2.319262182781068 0.0203808246208332 0.999999999999484 0.3248972990527297 5 P16278,P10619 2 +Mitochondrial calcium ion transport 0.6878727663031046 2.315746759216845 0.0205720997216793 0.9999999999996054 0.3248972990527297 17 P21796,P45880 2 +Heparan sulfate heparin hs gag metabolism 0.9049229813905162 2.2995253841716243 0.0214751236448429 0.9999999999998888 0.3303012094786078 5 P16278,P08236,Q7LGA3 3 +Hcmv early events 0.5566714148646486 2.2921354734412605 0.0218978269896692 0.9999999999999386 0.330633123997863 43 Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 6 +Neurotransmitter receptors and postsynaptic signal transmission 0.5798181310737225 2.2757910352383277 0.0228585195613091 0.999999999999984 0.3316390147475289 34 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Gpcr ligand binding 0.7811822980068276 2.235674138272193 0.0253731242834307 0.9999999999999996 0.3367439920860747 9 P07602,P05067,P42892 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.8137767428191075 2.230729520738028 0.0256990509479615 0.9999999999999996 0.3367439920860747 8 P46379,O43681,P05067,P09601 4 +Intra golgi and retrograde golgi to er traffic 0.4927156306615816 2.2235000623397516 0.0261820991886201 1.0 0.3367439920860747 87 Q9UJW0,P63167,O00461,P20645,P24390,Q9BVA1,P04350,Q15042,Q9BUF5,Q15102,O14579,P43034,Q13509,P68371,Q13885,O15260 16 +Metabolism of porphyrins 0.8093785950522181 2.2117799415637474 0.0269818737182285 1.0 0.3432693934152413 8 P30519 1 +Glycosphingolipid metabolism 0.6651310869869741 2.1917732722315697 0.0283958819504974 1.0 0.3535465647006514 17 P07602,P04062,O43681,Q9NZJ7,P16278,P10619,Q16739,Q13510 8 +Eukaryotic translation elongation 0.4737041400479234 2.189484801336031 0.0285616220391355 1.0 0.3535465647006514 73 Q9Y3U8,P15880,P26641,P50914,P39023,P32969,P46776,P62829,P84098,P29692,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,P36578,P46781,P47914,Q05639,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 45 +Cholesterol biosynthesis 0.6810845430270616 2.1736063614136096 0.0297347102694958 1.0 0.3583815079849758 15 Q9BWD1,Q14534,Q15800,Q16850,Q15392 5 +Biological oxidations 0.5439184317353605 2.1665179974373685 0.0302716260899755 1.0 0.3616801238924038 42 P78417,Q96KP4,P07099,Q8TB61,P16435,Q9NUJ1,Q16850,Q86WA6,O43252,P48507,O43169 11 +Peptide ligand binding receptors 0.8277049269937852 2.147728098942866 0.0317353618037352 1.0 0.3664564713201577 7 P07602,P05067,P42892 3 +Class a 1 rhodopsin like receptors 0.8277049269937852 2.147728098942866 0.0317353618037352 1.0 0.3664564713201577 7 P07602,P05067,P42892 3 +Diseases of carbohydrate metabolism 0.7313254661598051 2.141029740929137 0.0322716397596354 1.0 0.3664564713201577 10 P10253,P16278,P54802,O43826,P08236 5 +Deubiquitination 0.4773624469304974 2.1352651052148586 0.0327393615400697 1.0 0.3687203504594739 81 P21796,P45880,P49720,Q8NB78,Q96K76,O95630,Q96FW1,P60900,P28070,Q09472,Q86UV5,P20618,P49721,Q15018,O94966,Q9Y4E8,P28074,P25788,P51784,Q9Y277 20 +Transmission across chemical synapses 0.5394022154927269 2.1074891757320855 0.0350751989765252 1.0 0.3771029256976376 41 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 +Iron uptake and transport 0.6494705559831675 2.105374617908488 0.0352587114466915 1.0 0.3771029256976376 17 Q93050,P30519,P09601,P21281 4 +Glycosaminoglycan metabolism 0.6573823654809902 2.096186072014973 0.0360656879903189 1.0 0.3773444317699077 16 P16278,Q8TB61,P54802,P08236,Q8NCH0,P15586,Q7LGA3 7 +Response of eif2ak4 gcn2 to amino acid deficiency 0.4615387953246541 2.07770341011141 0.0377366847775608 1.0 0.380281670235748 72 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P05198,P62280,P46778,P18077,P62249,P08243,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 44 +Synthesis of substrates in n glycan biosythesis 0.6612087832699086 2.068436167178696 0.0385990272307548 1.0 0.380281670235748 15 P16278,Q86YN1,Q9Y223,P10619 4 +Organelle biogenesis and maintenance 0.4783731015793028 2.068071980212306 0.0386332550447579 1.0 0.380281670235748 88 Q9H6D7,Q15648,Q9BVA1,O75964,P04350,Q7Z460,Q9BUF5,P78371,A6NIH7,P07437,Q9Y512,P00846,Q13509,P68371,Q13885 15 +Recruitment of mitotic centrosome proteins and complexes 0.560221349786203 2.0668555374252433 0.0387477684374124 1.0 0.380281670235748 27 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 +Cellular response to chemical stress 0.4561789637175083 2.0346690360815183 0.0418841857990228 1.0 0.3999391903368412 71 P30519,Q15648,P60900,P49720,P28070,O75880,P00390,P09601,P20618,P00403,P49721 11 +Neuronal system 0.4943716147659115 2.034362852970524 0.0419150243147781 1.0 0.3999391903368412 51 O95197,Q9BVA1,P04350,Q9BUF5,Q15334,P10586,Q14168,Q13509,P68371,Q13885 10 +Nr1h2 and nr1h3 mediated signaling 0.834983514660232 2.0191756663077083 0.0434689645426074 1.0 0.4056461449435031 5 Q8NB78,Q9HCE1 2 +Phase ii conjugation of compounds 0.5535738876739282 2.016317391523435 0.04376679746462 1.0 0.4056461449435031 26 Q96KP4,Q8TB61,Q9NUJ1,P78417,P48507 5 +Aurka activation by tpx2 0.5515848058548619 2.013125388652334 0.0441014399199228 1.0 0.4056461449435031 28 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 +Mucopolysaccharidoses 0.9171362280410984 2.007339960690262 0.0447134769578008 1.0 0.4068630287418431 4 P16278,P54802,P08236 3 +Inflammasomes 0.91088636572468 1.9834278694487464 0.0473196566628784 1.0 0.4194658597083563 4 P09601 1 +Purinergic signaling in leishmaniasis infection 0.91088636572468 1.9834278694487464 0.0473196566628784 1.0 0.4194658597083563 4 P09601 1 +The nlrp3 inflammasome 0.91088636572468 1.983427869448744 0.0473196566628786 1.0 0.4194658597083563 4 P09601 1 +Transport of inorganic cations anions and amino acids oligopeptides 0.6846372994662671 1.9654271763815003 0.0493648166433653 1.0 0.4251297349602327 11 Q9Y6M7,Q70HW3 2 +Mapk family signaling cascades 0.4597809076228659 1.9561611702190005 0.0504461710991985 1.0 0.4252333686521401 81 Q9HCE1,P60900,P49720,P28070,P28074,Q13362,P20618,P49356,P30086,Q15334,O60725,P49721,Q9Y4G8,Q14168 14 +Trans golgi network vesicle budding 0.5306133159911177 1.93169973268429 0.0533965777991916 1.0 0.4293337516253295 35 Q8NC96,O60749,O00443,Q92538,P20645,Q9BXS5,P02786,Q9H3P7,Q14677,Q92572,Q9Y5X1,P05067,P15586 13 +Heme signaling 0.8133109913733043 1.9306490604865136 0.0535264663686096 1.0 0.4293337516253295 5 Q15648,Q09472,P09601 3 +Anchoring of the basal body to the plasma membrane 0.5395377931235908 1.9289263374882064 0.0537400076478016 1.0 0.4293337516253295 28 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 +Golgi associated vesicle biogenesis 0.5372068999154933 1.918731447231992 0.0550183295205166 1.0 0.4293337516253295 29 Q8NC96,O60749,O00443,Q9BXS5,P02786,Q9H3P7,Q14677,Q92572,Q9Y5X1,Q01968,P56377,P11717 12 +Diseases associated with glycosylation precursor biosynthesis 0.7419690079843748 1.916284391225021 0.0553289065511179 1.0 0.4293337516253295 8 P16278,P10619 2 +Separation of sister chromatids 0.4724408720298608 1.9003913970657105 0.0573817750522589 1.0 0.4293337516253295 98 P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q9BUF5,P49721,Q13509,P68371,Q13885 12 +Metabolism of folate and pterines 0.7369419730379735 1.8938764314973853 0.0582414135111035 1.0 0.4293337516253295 8 P00374 1 +Negative regulation of mapk pathway 0.6573105504629416 1.8791075361128853 0.0602298113455803 1.0 0.4343852098543753 12 Q13362 1 +Transport of small molecules 0.5079712695756026 1.8779794950769064 0.0603839702199313 1.0 0.4343852098543753 138 P08183,P30519,P21796,P45880,O43242,P49720,Q9UBX3,Q9BUN8,P09601,Q8WTV0,Q9C0H2,Q9Y487,P53985,P60900,P28070,Q8N4V1,Q96CW1,P20618,O15118,P49721,Q9HD20,P04920,Q70HW3,Q6PIU2,P35613,Q99808,Q93050,Q8TB61,Q9GZP9,Q4KMQ2,Q9H300,Q9BPX6,Q9Y6M7,P28074,P25788,Q9Y3S1,P21281,P35611,Q9Y277 39 +Degradation of beta catenin by the destruction complex 0.4957196019652607 1.854656199881771 0.0636453372046437 1.0 0.4497197942917751 45 P60900,P49720,P28070,Q13362,P49721 5 +Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.8682189147288311 1.8188626596606203 0.0689323858718029 1.0 0.4735654909392863 4 Q8NB78,Q9HCE1 2 +L1cam interactions 0.5054033528433902 1.8017609625918944 0.0715830220356541 1.0 0.4869062984009346 39 Q9BVA1,P04350,Q9BUF5,Q15334,O00560,Q13509,P68371,Q13885 8 +Mitotic prometaphase 0.4485385125185143 1.7951158167350545 0.0726352492555539 1.0 0.4893344622525587 85 Q9H6D7,Q9BVA1,Q13362,P04350,Q9BUF5,P07437,Q13509,P68371,Q13885 9 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5762202619046836 1.7950089232820856 0.0726522782383711 1.0 0.4893344622525587 19 Q9Y5P6,P16278,Q86YN1,P10619,Q9Y223 5 +Regulation of hmox1 expression and activity 0.494730056444256 1.754561884320452 0.0793342759241639 1.0 0.5046541440731541 41 P60900,P49720,P28070,P09601,P49721 5 +Synaptic adhesion like molecules 0.736187169296552 1.737332768046693 0.0823284508440578 1.0 0.5188958323841076 6 P10586,O95197 2 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.6461102874454188 1.7283040325191128 0.0839337304854348 1.0 0.5265979255113583 10 P05067,O15111,P09601,Q13685 4 +Selenoamino acid metabolism 0.4417931000191097 1.724952732339037 0.0845359912118983 1.0 0.5279656905688561 85 Q9Y3U8,P15880,Q9P2J5,P39023,P32969,P50914,Q13155,O43324,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,Q12904,O43252,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P23526,P36578,P46781,P47914,P00390,P61254,P08708,P32929,P46783,Q07020,P83881 46 +Glutathione synthesis and recycling 0.8426199956210475 1.7191068860469894 0.0855949111766514 1.0 0.5297630989041399 4 Q96KP4,P48507 2 +Negative regulation of the pi3k akt network 0.6111484215763812 1.6905332885441997 0.0909259752625475 1.0 0.5541077367963831 13 Q13362 1 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.6615917310289824 1.6832651330499124 0.0923237769519982 1.0 0.5541077367963831 9 O43681,O60725,P49366,P38435 4 +Metabolism of steroids 0.4939666271665081 1.6810429610357485 0.0927545702060903 1.0 0.5541077367963831 37 Q9BWD1,Q15436,Q14534,Q15648,P04062,Q15800,Q86X55,Q16850,P22059,Q15392,Q14739,P62826,P38435 13 +Slc mediated transmembrane transport 0.5458271049073931 1.667590165535897 0.0953971118473093 1.0 0.5636093562379911 20 P35613,Q9UBX3,Q9Y6M7,Q8TB61,P53985,Q70HW3 6 +Mitotic g1 phase and g1 s transition 0.4219042423864535 1.6666919377649487 0.0955756768584075 1.0 0.5636093562379911 72 P62191,P00374,P49720,O43242,P11802,P27694,P49643,Q7L590,Q07864,Q13309,O43913,Q00534,P14635,Q13616,P60900,P28070,O00487,P25787,P20618,P33992,P49721,P09884,P30153,P35244,P15927,O75832,P25786,P30154,P49736,P51665,Q9NRF9,Q9UL46,P28074,P25788,P06493,P12004,Q14566,P62333,Q9Y619 39 +Stimuli sensing channels 0.7040638963578287 1.617873177367845 0.105689931868051 1.0 0.5892371338391466 7 Q4KMQ2,Q9C0H2 2 +Regulation of plk1 activity at g2 m transition 0.4926385265223802 1.6167815065569353 0.1059254527352759 1.0 0.5892371338391466 32 Q9H6D7,P07437,P68371,P04350 4 +Asparagine n linked glycosylation 0.4548249570662657 1.6044194273929149 0.1086216315593007 1.0 0.5993820151103582 109 P63167,P24390,Q9BVA1,Q9Y296,Q9Y5P6,P10619,P49257,P68371,Q13885,Q12955,P04350,P16278,Q86YN1,P04066,O14579,Q2TAA5,Q9GZP9,Q9BUF5,Q13509,Q9UJW0,Q15436,Q9Y223 22 +Synthesis of pa 0.6968025439000187 1.5859762416853844 0.1127446991096638 1.0 0.6147270499074531 7 Q9NPH0 1 +Neddylation 0.4023335102889865 1.5808573619643065 0.1139106553055688 1.0 0.6186294086555401 62 P49720,O43242,Q8TBC4,Q13309,P60900,P28070,P20618,Q9BTE7,P49721,Q92905,Q99627,Q15345,Q96GG9,P61962,Q13617,P28074,P25788,O94888,Q9BT78 19 +Ion channel transport 0.4911214372417709 1.578797194278149 0.1143825823737401 1.0 0.6187467251240902 25 Q93050,P21281,Q9C0H2,Q9HD20,Q9Y487,Q4KMQ2 6 +Glycogen storage diseases 0.8027842227378141 1.562587697158004 0.1181496038928657 1.0 0.6278260877070667 4 P46976,O43826,P10253 3 +Srp dependent cotranslational protein targeting to membrane 0.4259606073384402 1.5589524435464055 0.1190076364024179 1.0 0.6278260877070667 85 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P49458,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P43307,Q15005,Q15629,P67812,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P36578,P46781,P47914,Q9Y5M8,P61254,P08708,P46783,Q07020,P83881 44 +Glycogen metabolism 0.6346486527270284 1.5547305792631252 0.1200102485709055 1.0 0.6278260877070667 9 P46976,P10253,P35573 3 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4970114373369417 1.5451888036441224 0.1223006017594383 1.0 0.6328525349421347 23 Q13126,Q53EL6 2 +Sphingolipid de novo biosynthesis 0.6072392002742127 1.5345949656772957 0.1248833500467692 1.0 0.637002275378253 10 P51648,P22059,O95470,Q96G23,Q9Y5P4 5 +Hedgehog ligand biogenesis 0.4749888807219609 1.5331416959348323 0.125240946108365 1.0 0.637002275378253 37 P60900,P49720,P28070,Q9GZP9,P49721 5 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.6845136219269978 1.5318358216896757 0.1255629539378282 1.0 0.637002275378253 7 Q09472,Q99873,P06493,Q86X55,P12004 5 +Traf6 mediated nf kb activation 0.6879113588228367 1.5275879590660952 0.1266148732010634 1.0 0.637002275378253 6 P09429,P05067 2 +Heme degradation 0.9729677287159932 1.5270028407791203 0.1267603049757002 1.0 0.637002275378253 3 P30519 1 +Ras processing 0.793029126292591 1.5240621869626196 0.1274931773864771 1.0 0.637002275378253 4 O60725 1 +Activation of nima kinases nek9 nek6 nek7 0.7148217680314228 1.5197727177553713 0.128568108187014 1.0 0.6383696300116408 5 P14635,P06493 2 +Phase i functionalization of compounds 0.558630415922752 1.506826201765114 0.1318552115688325 1.0 0.6441695392371791 15 P07099,Q16850,Q86WA6,O43169 4 +Mismatch repair 0.5930493624683979 1.50389171373093 0.1326092509438514 1.0 0.6441695392371791 11 Q9UQ84,P28340,P43246,P12004,P52701,P35244,P15927 7 +Abc family proteins mediated transport 0.4484527986314578 1.5035613595172173 0.1326943467164207 1.0 0.6441695392371791 47 P08183,P60900,P49720,P28070,Q9GZP9,P49721 6 +Cytosolic sulfonation of small molecules 0.7875356176816077 1.5023391857270882 0.1330095334638423 1.0 0.6441695392371791 4 Q8TB61 1 +Interleukin 12 signaling 0.4791145631589107 1.493561117024169 0.1352903687530808 1.0 0.6476967479677113 25 Q13126,Q53EL6 2 +Pyruvate metabolism 0.5314255179168311 1.473286306663804 0.1406738514252361 1.0 0.6585759971633327 18 P35613,P53985,P21796,Q16775 4 +Glycogen breakdown glycogenolysis 0.6745672969446779 1.4691012567035238 0.1418053269638295 1.0 0.6585759971633327 6 P10253,P35573 2 +Abc transporter disorders 0.4634155770001931 1.46883837004981 0.1418766340322752 1.0 0.6585759971633327 39 P60900,P49720,P28070,P28074,Q9BUN8,P25788,P20618,Q9GZP9,P49721 9 +Defective cftr causes cystic fibrosis 0.463415577000193 1.468838370049809 0.1418766340322754 1.0 0.6585759971633327 39 P60900,P49720,P28070,P28074,Q9BUN8,P25788,P20618,Q9GZP9,P49721 9 +Synthesis of pips at the plasma membrane 0.6416487239702718 1.4605508149349404 0.1441387526288315 1.0 0.661707999917728 8 O00443,Q8TBX8 2 +Metalloprotease dubs 0.6710816381060436 1.4537940278248065 0.1460034197482986 1.0 0.661707999917728 6 O00487,O95630,Q09472,Q15018 4 +Cyclin a cdk2 associated events at s phase entry 0.4630987678088186 1.4523507644026223 0.1464040989628743 1.0 0.661707999917728 38 P60900,P49720,P28070,P11802,P49721 5 +Scf skp2 mediated degradation of p27 p21 0.4630987678088187 1.4523507644026223 0.1464040989628743 1.0 0.661707999917728 38 P60900,P49720,P28070,P11802,P49721 5 +Tp53 regulates transcription of cell cycle genes 0.5625477327632967 1.4310266200406785 0.1524225860067556 1.0 0.6758455886397821 13 Q09472,Q9UKZ1,Q99873,P06493,Q86X55,Q9NZN8 6 +G1 s dna damage checkpoints 0.4571022144038706 1.4046238391992174 0.1601331638923504 1.0 0.6844387198743559 38 P60900,P49720,P28070,P28074,P25788,P20618,O14757,Q13315,P49721 9 +Hs gag degradation 0.9327369118621684 1.3816705489023338 0.1670728812181288 1.0 0.7047148468289943 3 P16278,P08236 2 +Rora activates gene expression 0.7569830427638743 1.3812468117673016 0.1672030859288589 1.0 0.7047148468289943 4 Q15648,Q09472 2 +Lysosome vesicle biogenesis 0.5527912152938863 1.378377399280134 0.1680867975718061 1.0 0.7062729659439193 13 P05067,P20645,P15586 3 +Diseases of glycosylation 0.500802711585405 1.3334122669276185 0.1823965490048176 1.0 0.7505731743038118 19 Q8NCH0,P16278,P10619 3 +Fatty acyl coa biosynthesis 0.5212843245155505 1.3302626457536184 0.1834317500407998 1.0 0.7505731743038118 16 P50897,Q9NZ01 2 +Apc c mediated degradation of cell cycle proteins 0.4128522575965936 1.3241069179086342 0.1854675383761499 1.0 0.7505731743038118 52 P62191,P49720,O43242,Q13042,Q13309,P14635,Q13257,Q13616,P60900,P28070,O00487,P25787,P20618,P30260,P49721,O75832,P53350,P51665,Q9UJX4,Q9UL46,P28074,P25788,O43684,P06493,P62333 25 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4346475463509924 1.3164384907268052 0.188026910577493 1.0 0.7505731743038118 44 P62191,P49720,O43242,Q13042,Q13309,P60900,P28070,O00487,P25787,P20618,P30260,P49721,O75832,P53350,P51665,Q9UJX4,Q9UL46,P28074,P25788,P62333 20 +Tnfr2 non canonical nf kb pathway 0.4459302961837441 1.3154049954529936 0.1883738275465531 1.0 0.7505731743038118 38 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721 9 +Dectin 1 mediated noncanonical nf kb signaling 0.4459302961837441 1.3154049954529936 0.1883738275465531 1.0 0.7505731743038118 38 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721 9 +Degradation of axin 0.4516459507393801 1.3143306997654152 0.1887349403937372 1.0 0.7505731743038118 33 P60900,P49720,P49721,P28070 4 +Cross presentation of soluble exogenous antigens endosomes 0.4516459507393801 1.3143306997654152 0.1887349403937372 1.0 0.7505731743038118 33 P60900,P49720,P49721,P28070 4 +Phosphorylation of the apc c 0.5486774138837776 1.3137829563549266 0.1889192547819249 1.0 0.7505731743038118 12 Q9UJX4,P30260,Q13042,P06493,P14635 5 +Regulation of ras by gaps 0.4501998196670569 1.3101502961614866 0.1901449963778656 1.0 0.7505731743038118 34 P60900,P49720,P49721,P28070 4 +Degradation of dvl 0.4501998196670569 1.3101502961614866 0.1901449963778656 1.0 0.7505731743038118 34 P60900,P49720,P49721,P28070 4 +Cellular response to hypoxia 0.4476539183794697 1.3074146451309134 0.1910719261599596 1.0 0.7505731743038118 36 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721 8 +Transport and synthesis of paps 0.8963232858562469 1.3041569614847268 0.192180070756295 1.0 0.7505731743038118 2 Q8TB61 1 +Plasma lipoprotein clearance 0.5537252128351091 1.3007302026519214 0.193350820340072 1.0 0.7505731743038118 11 Q8WTV0 1 +Stabilization of p53 0.4463301597506778 1.2970162406840309 0.194625598845044 1.0 0.7505731743038118 36 P60900,P49720,P28070,P28074,P25788,P20618,Q13315,P49721 8 +Proton coupled monocarboxylate transport 0.894335872805565 1.2963038101665665 0.1948708364211384 1.0 0.7505731743038118 2 P53985 1 +Transport of bile salts and organic acids metal ions and amine compounds 0.894335872805565 1.2963038101665665 0.1948708364211384 1.0 0.7505731743038118 2 P53985 1 +Apc c cdc20 mediated degradation of cyclin b 0.552814773073356 1.2960039911721244 0.1949741098503599 1.0 0.7505731743038118 11 P30260,P06493,Q13042,Q9UJX4 4 +Hdr through homologous recombination hrr 0.48694075920859 1.2956405560675817 0.1950993498282938 1.0 0.7505731743038118 20 Q9UQ84,Q9NRF9,P28340,O14757,Q13315,P12004,P40938,P15927 8 +Endosomal sorting complex required for transport escrt 0.5583192885615542 1.287221708364948 0.198017022888268 1.0 0.7578701655946527 10 Q8WUX9 1 +Cargo trafficking to the periciliary membrane 0.4929323002690655 1.2844500063255946 0.198984545499683 1.0 0.7594576819904569 19 A6NIH7 1 +Regulation of runx3 expression and activity 0.4442884632916201 1.2721573084851896 0.2033172326296384 1.0 0.7635123098033796 35 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721 8 +Interleukin 12 family signaling 0.4464564168640065 1.2572983614445137 0.2086456171083626 1.0 0.766780988510874 27 Q13126,Q53EL6 2 +Hedgehog on state 0.4393768247958228 1.252007445650841 0.2105671508898239 1.0 0.7715180408603147 37 Q96J02,P60900,P49720,P28070,P28074,P25788,P20618,P49721 8 +Signaling by notch4 0.4337771179117499 1.242815999261291 0.2139356454055092 1.0 0.7783009384566677 40 Q09472,P28070,Q9Y6A5,O43242,P49720,P60900,P28074,P25788,P20618,P49721 10 +Oncogene induced senescence 0.621980997342054 1.2372751123453594 0.2159849641661706 1.0 0.7789064062055603 6 P11802,Q9HCE1 2 +Sulfur amino acid metabolism 0.5394053628705667 1.2263187706712382 0.2200787403614286 1.0 0.7902494025578933 11 Q13126 1 +Runx3 regulates p14 arf 0.8764491553494544 1.2257823706340334 0.2202805831001988 1.0 0.7902494025578933 2 Q09472 1 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.565777415721931 1.2215660000363178 0.2218717926814117 1.0 0.7915251399294022 9 P63104,O14757,Q04917,P06493,P14635 5 +Synthesis of pg 0.874130506790332 1.216664564739836 0.2237318665069398 1.0 0.7925963861933503 2 Q8IV08 1 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.5429230185163237 1.2088591165153084 0.2267169752667222 1.0 0.7925963861933503 10 P30260,Q13309,Q13042 3 +Uch proteinases 0.4276397839628847 1.206469761415638 0.2276364116299019 1.0 0.7925963861933503 41 P60900,P49720,P28070,Q8NB78,P20618,P49721 6 +Plasma lipoprotein assembly remodeling and clearance 0.5197562097012829 1.1992052007100666 0.2304481655371097 1.0 0.7925963861933503 13 Q8WTV0 1 +Resolution of d loop structures 0.639388240439676 1.1989255154688772 0.2305569093325088 1.0 0.7925963861933503 5 Q9UQ84 1 +Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.639388240439676 1.1989255154688772 0.2305569093325088 1.0 0.7925963861933503 5 Q9UQ84 1 +Eukaryotic translation initiation 0.4030496727404566 1.1945742632641871 0.2322534096735955 1.0 0.7925963861933503 96 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P49770,P62829,P84098,Q9NR50,P27635,P18621,P55010,P30050,P46782,P61513,Q13144,P62753,Q15056,Q02543,O15372,P62701,P62244,P62917,P83731,P62266,Q9Y262,P62888,Q14232,O75821,P46779,Q02878,P61313,P62241,P35268,P05198,P62841,P62280,P46778,P18077,P62249,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,O00303,P46783,Q07020,O75822,Q14240,P83881 55 +Pexophagy 0.8675057966213997 1.190648986381524 0.2337914122815343 1.0 0.7931590135180941 2 P50542 1 +Fanconi anemia pathway 0.6362513858150466 1.1855629072940583 0.2357949579345084 1.0 0.7962266907552972 5 P27694,P35244,P15927 3 +Negative regulation of notch4 signaling 0.430515705026758 1.18156430233227 0.2373786249468326 1.0 0.7962266907552972 37 P60900,Q9Y6A5,P49720,P28070,P28074,P25788,P20618,P49721 8 +Metabolism of polyamines 0.431981210997167 1.1761281042419518 0.2395436888505777 1.0 0.7962266907552972 35 P60900,P49720,P49721,P28070 4 +Nonsense mediated decay nmd 0.3836872888927029 1.1658172497726824 0.2436883413903203 1.0 0.7962266907552972 80 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,P30153,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P36578,P46781,P47914,P61254,P08708,P46783,Q07020,P83881 39 +Switching of origins to a post replicative state 0.3823466776600789 1.1642161200749093 0.2443364390974765 1.0 0.7962266907552972 56 P62191,P49720,O43242,Q13042,Q13309,O43913,Q13616,P60900,P28070,O00487,P25787,P20618,P33992,P30260,P49721,O75832,P25786,P49736,P51665,Q9UJX4,Q9UL46,P28074,P25788,Q14566,P62333,Q9Y619 26 +Mapk6 mapk4 signaling 0.4187557480333341 1.163350525575925 0.2446873138748175 1.0 0.7962266907552972 43 Q9HCE1,P60900,P49720,O43242,P28070,O00487,Q9UL46,P28074,P25788,P20618,P06493,P63000,P49721 13 +Tcf dependent signaling in response to wnt 0.3704201843475109 1.159964088621393 0.2460634274656208 1.0 0.7962266907552972 59 P60900,P49720,P28070,Q13362,P49721 5 +Degradation of gli1 by the proteasome 0.4269354268086349 1.1530743449903538 0.2488798707465656 1.0 0.7962266907552972 37 Q96J02,P60900,P49720,P28070,P28074,P25788,P20618,P49721 8 +Mitotic metaphase and anaphase 0.4294680884551644 1.1516585568901163 0.249461408603733 1.0 0.7962266907552972 128 P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q86XL3,Q9BUF5,P49721,Q9BTX1,Q8WUX9,Q13509,P68371,Q13885 15 +Transcriptional regulation by runx3 0.424028067203475 1.1506889596353094 0.2498602201273043 1.0 0.7962266907552972 39 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721,P25440 9 +Association of tric cct with target proteins during biosynthesis 0.4841575232977496 1.1483659285569032 0.250817532894473 1.0 0.7962266907552972 17 P78371,Q9H0D6,P51784,P04062 4 +Auf1 hnrnp d0 binds and destabilizes mrna 0.4260394459302001 1.1459429438907744 0.2518187608354969 1.0 0.7962266907552972 37 P60900,P49720,P49721,P28070 4 +Unwinding of dna 0.57322093444916 1.1426087686870778 0.2532010632242083 1.0 0.7962266907552972 8 P49736,P33991,Q9BRX5,P33992,Q14566,P33993 6 +Bicarbonate transporters 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.7962266907552972 2 Q9Y6M7 1 +Crmps in sema3a signaling 0.6227708439441089 1.1281885758895005 0.2592402875558104 1.0 0.7962266907552972 5 Q9BPU6 1 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.8566399736387251 1.108117969256621 0.2678108714740175 1.0 0.7962266907552972 3 P11802 1 +Constitutive signaling by akt1 e17k in cancer 0.8456442530639294 1.105235830273454 0.2690574150298439 1.0 0.7962266907552972 2 P42345 1 +Asymmetric localization of pcp proteins 0.4236503853823279 1.1047961946806382 0.2692479097809315 1.0 0.7962266907552972 34 P60900,P49720,P49721,P28070 4 +Signaling by the b cell receptor bcr 0.4128345862091722 1.0838483475214613 0.2784320446304522 1.0 0.7962266907552972 41 P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721,O43865 9 +Downstream signaling events of b cell receptor bcr 0.4167190400806594 1.080940871562286 0.2797234163465418 1.0 0.7962266907552972 38 P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721 8 +Bmal1 clock npas2 activates circadian gene expression 0.8469184890656232 1.0735318227781063 0.2830325684760291 1.0 0.7962266907552972 3 Q15648,P43490 2 +Interleukin 1 family signaling 0.4061186116881179 1.0725787499782815 0.2834601633196418 1.0 0.7962266907552972 44 P60900,P49720,P28070,P28074,P25788,P20618,P05067,P49721,O15111,P09429 10 +Regulation of mecp2 expression and activity 0.534334766380861 1.0685748459985025 0.2852612879867815 1.0 0.7962266907552972 9 Q14739,P42858 2 +Interleukin 1 signaling 0.4073914863252091 1.0671590731707998 0.2859000101537554 1.0 0.7962266907552972 43 P60900,P49720,P28070,P28074,P25788,P20618,P05067,P49721,O15111,P09429 10 +Vitamin b5 pantothenate metabolism 0.6760639167452873 1.060655495232985 0.2888464924077776 1.0 0.7997424458771506 4 Q9NRN7 1 +Regulation of expression of slits and robos 0.4058817995025723 1.0579865741591667 0.2900615633392236 1.0 0.7997424458771506 112 Q9Y3U8,P62191,P15880,P49720,O43242,P50914,P39023,P32969,P46776,P62829,P84098,P60900,P28070,P27635,O00487,P18621,P25787,P20618,P30050,P46782,P61513,P62753,P49721,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,O75832,P25786,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,Q13617,P36578,P46781,P47914,P51665,Q9UL46,P28074,P61254,P25788,P08708,P62847,P62277,P46783,Q07020,P62333,P46777,P83881 60 +Role of phospholipids in phagocytosis 0.8423994329735425 1.0574982200707927 0.2902842665280021 1.0 0.7997424458771506 3 Q8IV08 1 +Antigen processing cross presentation 0.4043156085434212 1.057145832215586 0.2904450367486886 1.0 0.7997424458771506 44 P60900,P49720,P28070,P28074,Q9UIQ6,P25788,P20618,O15111,P49721,P09429 10 +Synthesis of dna 0.3700322650904628 1.053732913661063 0.2920052154612209 1.0 0.8016586467473256 77 P62191,P49720,O43242,P27694,P49643,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 36 +Diseases of dna repair 0.5309884759137057 1.0523170720653934 0.2926541015863004 1.0 0.8016586467473256 9 Q13315,Q9UQ84 2 +Cargo recognition for clathrin mediated endocytosis 0.4173910609037531 1.0496507092141372 0.2938787336281574 1.0 0.8016586467473256 25 Q8NC96,P20645,Q96CW1,P02786,Q92905,Q99627,Q14108,Q9NVZ3 8 +Antigen processing ubiquitination proteasome degradation 0.3748969651324501 1.0486505769763068 0.2943389688099826 1.0 0.8016586467473256 82 Q96J02,P49720,O43242,Q8TBC4,Q13042,Q13309,P61088,P60900,P28070,P30260,P20618,P19474,P55786,P49721,O94822,Q9UIQ6,Q15345,Q13617,P28074,P25788,Q15386,P52888 22 +Basigin interactions 0.5485876818621762 1.0280775564257585 0.303913347020581 1.0 0.8187783113848596 8 P35613,P53985,Q9UPY5,Q13356 4 +Clec7a dectin 1 signaling 0.3972758326119757 1.0137016908440863 0.3107251170203697 1.0 0.8273959511356358 45 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721,O43865 10 +Budding and maturation of hiv virion 0.5442861753629673 1.008133548272237 0.3133903540283247 1.0 0.8302350458821092 8 Q8WUX9,A5D8V6 2 +Cellular response to starvation 0.3710885314369298 1.007813545606842 0.3135439818041985 1.0 0.8302350458821092 82 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P42345,P46779,Q02878,P61313,P62241,P35268,P05198,P62841,P62280,P46778,P18077,P62249,P08243,Q96EE3,P23396,P36578,P46781,P47914,P61254,P21281,P08708,P62847,P62277,P46783,Q07020,P83881 47 +Glutathione conjugation 0.488911918212218 0.996191975344359 0.3191568776542568 1.0 0.8365791337088914 12 P78417,P48507 2 +C type lectin receptors clrs 0.3855951997908317 0.9904294057287858 0.3219642784006411 1.0 0.8394286878984457 49 P60900,P49720,Q09472,P28070,P28074,P25788,Q8TBC4,P20618,O15111,P49721,O43865 11 +Sema3a pak dependent axon repulsion 0.5648326894800518 0.9854159424524804 0.3244198018746353 1.0 0.8418505002246173 6 O14786,P07900 2 +Cytosolic iron sulfur cluster assembly 0.5648048154247706 0.9852938872654936 0.3244797344261227 1.0 0.8418505002246173 6 Q9Y5Y2,P18074,Q96T76,P28340 4 +Signaling by notch2 0.8135144087446208 0.9813359090049206 0.3264271202810045 1.0 0.8418505002246173 2 Q09472 1 +Activated notch1 transmits signal to the nucleus 0.8135144087446196 0.981335909004916 0.3264271202810067 1.0 0.8418505002246173 2 Q96J02 1 +Metabolism of nitric oxide nos3 activation and regulation 0.5876115047573427 0.9793362745485348 0.327413852688331 1.0 0.8424468793890764 5 P35270 1 +Nectin necl trans heterodimerization 0.8102020536601577 0.9687023132412516 0.3326937380714863 1.0 0.8496676507624947 2 Q9BY67 1 +Rac2 gtpase cycle 0.406096566701154 0.9620119954881824 0.3360435783691633 1.0 0.8545084063529333 32 Q13505,Q86XL3,Q9Y512,Q8TAA9,Q14739,P49257,O15173 7 +Keratan sulfate keratin metabolism 0.5588304314172741 0.9591639065326204 0.3374761801852517 1.0 0.8545084063529333 6 P16278,P15586 2 +Protein protein interactions at synapses 0.4753938915195445 0.9581102268518508 0.3380071790618009 1.0 0.8545084063529333 13 P10586,O95197,Q15334 3 +Cdt1 association with the cdc6 orc origin complex 0.4023541023148697 0.9574886945957884 0.3383206499679736 1.0 0.8545084063529333 37 P60900,P49720,P28070,P28074,P25788,P20618,P49721,O43913,Q9Y619 9 +Dual incision in gg ner 0.4111551063751754 0.9503460425126644 0.3419364510500617 1.0 0.8600019412978067 23 Q9NRF9,P28340,Q9UGN5,Q86WJ1,P12004,P19447,P40938,P32780,P15927 9 +Orc1 removal from chromatin 0.3854952209613809 0.9475210972052612 0.3433733110231918 1.0 0.8600019412978067 47 P60900,P49720,P28070,P28074,P25788,P20618,P49721,O43913,Q14566,Q9Y619 10 +Homologous dna pairing and strand exchange 0.472767089510165 0.943891647582158 0.3452250206515377 1.0 0.8600019412978067 13 Q13315,Q9UQ84,O14757,P40938 4 +Pyroptosis 0.6457356287627627 0.942046310591106 0.3461689304174749 1.0 0.8600019412978067 4 Q8WUX9 1 +Myoclonic epilepsy of lafora 0.8022524014574388 0.9385067963828024 0.3479840259054407 1.0 0.8614955884577938 2 P46976 1 +Repression of wnt target genes 0.8006871777249014 0.9111843552272344 0.3621982457723369 1.0 0.8810166737413452 3 Q13363 1 +Dna replication initiation 0.5710865384504784 0.910061408310373 0.3627901254142043 1.0 0.8810166737413452 5 P09884,Q07864,Q9NRF9 3 +Role of abl in robo slit signaling 0.799921229027953 0.9085316781736495 0.3635973848886773 1.0 0.8810166737413452 3 Q7Z460 1 +Mapk3 erk1 activation 0.63678511175373 0.9073819428747364 0.364204854938198 1.0 0.8810166737413452 4 P06493 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5004207240738598 0.9044792114571634 0.3657413526923618 1.0 0.8831785915629266 9 P30260,Q13042 2 +Transcriptional regulation by runx2 0.3843528071198292 0.9020634911364268 0.3670231414222524 1.0 0.8847189409020612 45 P60900,P49720,P28070,P11802,P49721 5 +Resolution of abasic sites ap sites 0.3963443252420567 0.8938951153999465 0.3713780114928624 1.0 0.890529472584979 26 Q96T60,Q9NRF9,Q86W56,Q9UGN5,P28340,P12004,Q07864,P40938,P29372,P15927 10 +Leishmania infection 0.3929685524671498 0.8904045313418802 0.3732487101306299 1.0 0.8927495870769729 38 P05067,P09601,Q9UQB8 3 +Regulation of runx2 expression and activity 0.3925582111103375 0.8871250676717507 0.3750115692887599 1.0 0.8945588475742294 38 P60900,P49720,P49721,P28070 4 +Purine ribonucleoside monophosphate biosynthesis 0.4962104419914216 0.8842568329915925 0.3765575849653646 1.0 0.8966899856887539 9 Q06203,P30566,P30520,P22102 4 +Rho gtpase effectors 0.3814800918163463 0.8808864273822506 0.3783792943770869 1.0 0.8994691184673312 104 P63167,P33176,Q9BVA1,Q13362,P04350,Q7Z460,P49454,Q9BUF5,Q15334,O15145,Q9UQB8,P43034,P60660,Q13509,P68371,Q13257,Q13885,Q9P258 18 +Met activates ras signaling 0.6293230818993264 0.8786311610786575 0.3796012944154507 1.0 0.9008155069548004 4 Q96S59,P62993 2 +Stat3 nuclear events downstream of alk signaling 0.624665340945109 0.8607606918699462 0.3893698585533871 1.0 0.9098540572318944 4 Q09472 1 +Keratan sulfate degradation 0.6229242626032024 0.8540965002855694 0.3930515228786453 1.0 0.9150440456899565 4 P16278 1 +Tcr signaling 0.3787031405078307 0.853432037811677 0.393419761196959 1.0 0.9150440456899565 45 P50552,P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721 9 +Vitamin d calciferol metabolism 0.7827055323488716 0.8493084782810583 0.3957096644025228 1.0 0.915620153324307 3 P04062 1 +Regulation of mrna stability by proteins that bind au rich elements 0.3468376141797332 0.8411746831390152 0.4002500812163649 1.0 0.9211356874552782 57 P60900,P49720,P28070,P28074,Q9NQT4,Q15024,P25788,P20618,P49721,Q92945,Q9NQT5 11 +Carnitine metabolism 0.5542520023258284 0.8401802212678334 0.4008073463356296 1.0 0.9211356874552782 5 P23786 1 +Processive synthesis on the c strand of the telomere 0.4685456661731371 0.8319117706379653 0.4054587474046567 1.0 0.925981924981828 10 P35244,P28340,P12004,Q15554,P15927 5 +Ddx58 ifih1 mediated induction of interferon alpha beta 0.4458017494584589 0.8311110348358159 0.4059109064961848 1.0 0.925981924981828 14 Q96J02,Q09472,P07900,P05067,O15111,P09429 6 +Glycogen synthesis 0.5514778120310384 0.8287455206942144 0.4072484216049798 1.0 0.925981924981828 5 P46976 1 +Response to elevated platelet cytosolic ca2 0.3876088435354153 0.8213131100176164 0.4114679420570137 1.0 0.9328610308427115 31 P07602,Q9NZJ7,Q9NUQ9,Q8NBX0,P07737,Q6UXV4,Q01518,P13473,P05067,Q08380,O94919,O43852 12 +Pi metabolism 0.4372651329542798 0.8184052389922613 0.4131258312220125 1.0 0.9328610308427115 15 O00443,Q9Y217,Q8TBX8 3 +Signaling by robo receptors 0.395613779900809 0.8134954241807696 0.4159340687275659 1.0 0.9328610308427115 126 Q9Y3U8,P62191,P15880,P49720,O43242,P50914,P39023,P32969,Q01518,P63000,P46776,P35080,P62829,P84098,O14786,P60900,P28070,P50552,P27635,O00487,P18621,Q7Z460,P25787,P20618,P30050,P46782,P07737,P61513,P49721,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,Q13617,P36578,P46781,P47914,P51665,Q9UL46,P28074,P61254,P25788,P08708,P46783,Q07020,P62333,P83881 60 +Small interfering rna sirna biogenesis 0.7685637475554474 0.8012958811895907 0.4229603747593886 1.0 0.9328610308427115 3 Q15631 1 +Pcp ce pathway 0.3771666674992053 0.8002863667521996 0.4235449001145386 1.0 0.9328610308427115 42 P60900,P49720,P28070,Q96CW1,P28074,P25788,P20618,P07737,P49721 9 +Signaling by notch3 0.5220718986909788 0.8002192863847781 0.4235837574847547 1.0 0.9328610308427115 6 Q09472,Q9Y6A5 2 +Potential therapeutics for sars 0.3839962689033079 0.796403980964158 0.4257972651021113 1.0 0.9345773837864232 33 P07437,Q99720 2 +Hdr through single strand annealing ssa 0.44811143656846 0.7816579659955455 0.4344156109033728 1.0 0.944857870440316 12 Q13315,Q9UQ84,P40938 3 +Regulated necrosis 0.436701533342303 0.7813322386516074 0.4346071136232021 1.0 0.944857870440316 14 P09429,O00560,Q8WUX9,Q8WUM4 4 +Aryl hydrocarbon receptor signalling 0.7621427446365032 0.7797091065320559 0.4355621174169815 1.0 0.945147331520817 3 O00170 1 +Adaptive immune system 0.4285728394011189 0.7738467764293725 0.4390214070071683 1.0 0.945147331520817 171 Q96J02,P63167,P49720,O43242,Q9BVA1,Q13362,Q8TBC4,Q13042,P10619,P68371,Q13885,P47755,P33176,P50552,P60900,P28070,Q9BXS5,Q96CW1,P04350,P30260,P20618,P19474,P55786,P49721,O43865,O94822,P42345,Q9UIQ6,Q9BUF5,O15111,Q15345,P09429,Q13509,Q9UJW0,Q9NZ08,Q15436,P28074,P25788,Q15386,P52888 40 +Activation of the pre replicative complex 0.4047767214342979 0.771236588349531 0.4405667107485134 1.0 0.945147331520817 20 P49736,Q9NRF9,P27694,P49643,Q7L590,P33992,Q07864,O43913,Q14566,Q9Y619,P09884,P35244,P15927 13 +Clathrin mediated endocytosis 0.3604402310567012 0.7631972815828544 0.4453457497630768 1.0 0.945979993505518 49 Q8NC96,O00443,Q15642,P20645,P02786,Q96CW1,Q9Y5X1,Q99627,Q14108,Q9NVZ3,O15145 11 +Nef mediated downregulation of mhc class i complex cell surface expression 0.5350128396509777 0.7614434653185964 0.4463922343701423 1.0 0.945979993505518 5 P56377,Q9BXS5 2 +Circadian clock 0.4534082486360659 0.7567101654144539 0.4492235232974919 1.0 0.9476637886917731 10 P43490,Q15648,Q09472 3 +Metabolism of water soluble vitamins and cofactors 0.378449404638523 0.7544740706985182 0.4505646093162347 1.0 0.9476637886917731 33 P00374,P43490,Q9H2D1,P78417,O00764 5 +Termination of translesion dna synthesis 0.4212858176999485 0.7507297099143495 0.4528153390926046 1.0 0.9498752304018911 16 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,P35244,P15927 8 +Processive synthesis on the lagging strand 0.4442877309318835 0.735574061150925 0.4619899530540423 1.0 0.9647053271470954 11 P28340,P27694,P12004,P09884,P35244,P15927 6 +Dna strand elongation 0.3735803775751219 0.735571777946467 0.461991342986018 1.0 0.9647053271470954 25 P49736,P28340,P27694,P49643,P33992,P12004,P40938,P33993,P09884,Q14566,P35244,P15927 12 +Fgfr2 alternative splicing 0.4216871128350987 0.7314075083436749 0.4645302804697135 1.0 0.9670675838869492 15 O43251,O15514,P30876 3 +Transcriptional regulation by mecp2 0.4375321278715032 0.7269647172952282 0.4672475699316933 1.0 0.969785741821974 12 Q14739,P42858 2 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.406103021905257 0.7141826431200532 0.475114248171002 1.0 0.970762696648788 18 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,Q92890,P35244,P15927 9 +Beta catenin independent wnt signaling 0.3602969922152182 0.7105175857102762 0.4773832296167177 1.0 0.970762696648788 46 Q9HCE1,P60900,P49720,P28070,Q96CW1,P28074,P25788,P20618,P07737,P49721 10 +Regulation of pten stability and activity 0.3701622262717767 0.7094909628963771 0.4780198575950229 1.0 0.970762696648788 38 P60900,P49720,P49721,P28070 4 +Unblocking of nmda receptors glutamate binding and activation 0.5842181380241604 0.7086390523776539 0.478548495409228 1.0 0.970762696648788 4 Q15334 1 +Ras activation upon ca2 influx through nmda receptor 0.5842181380241604 0.7086390523776539 0.478548495409228 1.0 0.970762696648788 4 Q15334 1 +Ptk6 regulates proteins involved in rna processing 0.7379927128188193 0.702881224615848 0.4821297727876801 1.0 0.970762696648788 2 Q07666 1 +Ra biosynthesis pathway 0.5823319487607321 0.7017057136393073 0.4828627090660689 1.0 0.970762696648788 4 Q9BTZ2 1 +Regulation of runx1 expression and activity 0.5812329344190847 0.6976735896502134 0.485381348324394 1.0 0.970762696648788 4 Q9HCE1 1 +Disorders of transmembrane transporters 0.3287653774559087 0.692718000318607 0.4884865405423757 1.0 0.9718034285794568 70 P35613,P60900,P49720,P28070,P28074,P20618,Q9GZP9,P49721,Q9BTX1,A8CG34,P53985 11 +Activation of bh3 only proteins 0.4746533429812733 0.6913720784891491 0.4893317461091657 1.0 0.9718034285794568 8 P63167,Q96FJ2,Q04917 3 +Alpha oxidation of phytanate 0.5767008184288649 0.6811072316947131 0.4958036415096063 1.0 0.9718034285794568 4 P51648 1 +Transcriptional regulation of white adipocyte differentiation 0.417580525128105 0.6503326277271809 0.515477385717273 1.0 0.9953821956919824 13 P11802,Q15648,Q09472 3 +Diseases of mismatch repair mmr 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.9953821956919824 3 P52701 1 +Synthesis of ip2 ip and ins in the cytosol 0.7204372308711551 0.6419438884784698 0.5209096163957856 1.0 0.9953821956919824 2 Q01968 1 +Microrna mirna biogenesis 0.4439169810186576 0.6385215699766168 0.5231342175243745 1.0 0.9953821956919824 9 O15514,P30876,P62826 3 +Dna replication pre initiation 0.3265547041637411 0.6380014371949911 0.5234727445388025 1.0 0.9953821956919824 57 P62191,P49720,O43242,P27694,P49643,Q7L590,Q07864,O43913,P60900,P28070,O00487,P25787,P20618,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P49736,P51665,Q9NRF9,Q9UL46,P28074,P25788,Q14566,P62333,Q9Y619 29 +Phosphorylation of emi1 0.7180251822398915 0.6357453089011343 0.5249424395068165 1.0 0.9953821956919824 3 P06493,P14635 2 +Cristae formation 0.3826347533444976 0.6335373437337805 0.5263828023728441 1.0 0.9953821956919824 20 P00846,O75964,Q9Y512,Q13505 4 +Intracellular signaling by second messengers 0.3336071549744683 0.6318183467152909 0.5275055837031326 1.0 0.9953821956919824 80 Q9HCE1,P60900,P49720,O43242,P28070,P28074,Q13362,P42345,P25788,P20618,Q8TBX8,P49721,O15111,O43865 14 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.3598923018882953 0.6247319324782775 0.5321470114298172 1.0 0.9976053096397208 37 P60900,P49720,P49721,P28070 4 +Metabolism of ingested semet sec mesec into h2se 0.7148062272275647 0.6227905887782619 0.5334221436285067 1.0 0.9985313696806108 2 P32929 1 +Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.4778455980167354 0.6158240886430709 0.5380106271263663 1.0 1.0 6 P09429,O15111,P05067 3 +Negative regulation of nmda receptor mediated neuronal transmission 0.4973844448257393 0.6123092133165995 0.5403331950946355 1.0 1.0 5 Q15334 1 +Inhibition of replication initiation of damaged dna by rb1 e2f1 0.4968197657608725 0.6101325366458905 0.5417740149496522 1.0 1.0 5 P09884,P49643,P30153 3 +Enos activation 0.7095762122098569 0.6091909187794091 0.5423978989432485 1.0 1.0 3 P35270 1 +Insulin receptor recycling 0.4365872411640657 0.605231634691708 0.545025099075743 1.0 1.0 9 Q93050,P21281 2 +Fceri mediated nf kb activation 0.3527667395296263 0.6008948581854326 0.5479100181260819 1.0 1.0 42 P60900,P49720,P49721,P28070 4 +Metabolism of lipids 0.4138679763021898 0.5983393783292843 0.549613506520787 1.0 1.0 174 Q9BWD1,O00443,P09960,Q15165,P35790,Q8NCC3,Q9NZ01,Q9NPH0,Q16850,P10619,Q14739,O95864,P62826,P38435,Q09472,P16278,P48739,O43681,Q96G23,Q9Y5P4,Q9Y217,P51648,Q8IV08,P50897,P48651,Q15800,Q99943,P23786,Q86X55,P49748,Q9Y6X9,O00154,Q13510,P07602,Q15648,Q14534,Q15436,P04062,Q96N66,Q9NZJ7,O95470,Q8TBX8,Q15392,Q16880,Q16739,O43772,Q8WUK0 47 +Signaling by notch1 0.453231888800966 0.5980618604719652 0.5497986575630409 1.0 1.0 8 Q96J02,Q09472 2 +Notch3 activation and transmission of signal to the nucleus 0.7011174629937037 0.5829857279239811 0.5599029080039777 1.0 1.0 3 Q9Y6A5 1 +Platelet calcium homeostasis 0.5489802275148432 0.5821811728501063 0.5604446534923837 1.0 1.0 4 P16615 1 +Reduction of cytosolic ca levels 0.5489802275148432 0.5821811728501063 0.5604446534923837 1.0 1.0 4 P16615 1 +Ros and rns production in phagocytes 0.4491655502114321 0.580687633869353 0.5614509975932134 1.0 1.0 8 Q93050,P21281 2 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.3678932076550311 0.5757007524187899 0.5648174666910815 1.0 1.0 21 Q9NRF9,Q86W56,Q9UGN5,P28340,P12004,Q07864,P40938,P35244,P15927 9 +Diseases of metabolism 0.344526960922194 0.5643722025382631 0.5725008525899578 1.0 1.0 45 P10253,P16278,P54802,O43826,P08236,P10619,Q8NCH0,P48507,Q9Y223 9 +Fc epsilon receptor fceri signaling 0.3356252783780937 0.5609707289483352 0.5748174916985072 1.0 1.0 50 P60900,P49720,P28070,P20618,P49721 5 +Apc cdc20 mediated degradation of nek2a 0.4041062938495458 0.5585748660723214 0.5764518972136776 1.0 1.0 12 P30260,Q13257,Q13042,O43684 4 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.4041062938495458 0.5585748660723214 0.5764518972136776 1.0 1.0 12 P30260,Q13257,Q13042,O43684 4 +Notch4 activation and transmission of signal to the nucleus 0.6919509771447567 0.547240720294544 0.5842133640128508 1.0 1.0 2 Q92542 1 +Signaling by notch 0.3219604714125189 0.5402937941952304 0.5889944374509999 1.0 1.0 55 Q96J02,Q9HCE1,Q09472,Q9Y6A5,O43242,P49720,P28070,P60900,P28074,P25788,P20618,P15291,Q92542,P49721 14 +Late endosomal microautophagy 0.421731561362322 0.5389922171762661 0.5898922247776932 1.0 1.0 9 Q8WUX9 1 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.456971134621487 0.5328464680253746 0.594139864216912 1.0 1.0 6 Q9NR77 1 +G alpha i signalling events 0.3490357103614332 0.529163565288962 0.5966919891162106 1.0 1.0 23 P07602,P05067,O43865 3 +Dna damage bypass 0.3650163636760336 0.5269321715188247 0.5982406918295391 1.0 1.0 20 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,Q92890,P35244,P15927 9 +Purine salvage 0.5309910507126188 0.520565109625767 0.6026697600334501 1.0 1.0 4 P00491,P07741,P55263 3 +Activation of atr in response to replication stress 0.3634762617590181 0.5177752651905686 0.6046150779267565 1.0 1.0 20 Q7L590,O14757,O43913,Q14566,P40938,Q9Y619 6 +Signaling by wnt 0.3201924048331235 0.5145447395014086 0.6068711891430083 1.0 1.0 78 Q9HCE1,Q13363,P49720,O43242,P60900,P28070,Q13362,Q09472,P28074,P20618,Q96CW1,Q9UBQ0,P07737,P25788,P49721 15 +Transferrin endocytosis and recycling 0.4015557872964288 0.5091373177208702 0.610655975886095 1.0 1.0 10 Q93050,P21281 2 +Signaling by interleukins 0.3402959296585311 0.5029459201082355 0.6150022947379421 1.0 1.0 99 Q13126,P60900,P49720,P28070,P09601,P20618,P49721,Q53EL6,P78417 9 +Cytochrome p450 arranged by substrate type 0.6711746039929785 0.4936247536801373 0.6215712155670918 1.0 1.0 3 Q16850 1 +Telomere c strand synthesis initiation 0.4648416722873824 0.490654248595442 0.6236710105756527 1.0 1.0 5 P09884,Q15554 2 +Recognition of dna damage by pcna containing replication complex 0.3726154677254833 0.4822189649418343 0.6296504058701446 1.0 1.0 16 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 +Gap filling dna repair synthesis and ligation in gg ner 0.3690168016359584 0.4799445644475821 0.631266811841112 1.0 1.0 17 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 +Rhov gtpase cycle 0.3873249952676448 0.4775409268032636 0.6329769846590874 1.0 1.0 12 O43396 1 +Activation of bad and translocation to mitochondria 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 1.0 5 P62258,P31946,P63104,Q04917 4 +Nod1 2 signaling pathway 0.4398219071142427 0.467305906340742 0.6402810313283132 1.0 1.0 6 Q96J02,O15111,Q13685 3 +Tryptophan catabolism 0.6654521364690373 0.4646232262438037 0.6422012964391492 1.0 1.0 2 Q6YP21 1 +Formation of incision complex in gg ner 0.3702631914010634 0.4559085478715871 0.6484557425159643 1.0 1.0 15 P18074,Q9UGN5,P32780,Q86WJ1,P19447,P61088,P35244,P15927 8 +Rhou gtpase cycle 0.3735841717310945 0.450469225040419 0.6523721397487696 1.0 1.0 14 O43396 1 +Homology directed repair 0.335679590520393 0.4407193144968698 0.6594162120602276 1.0 1.0 34 Q9UQ84,Q9NRF9,P28340,Q9UGN5,O14757,Q13315,P12004,Q07864,P40938,Q9UNS1,P15927 11 +Metabolism of vitamins and cofactors 0.3332086146298855 0.4403412222714777 0.6596899889030383 1.0 1.0 41 P00374,P43490,P35270,Q9H2D1,Q9NRN7,P78417,O00764 7 +Long term potentiation 0.4505032930152981 0.4398887417657232 0.6600176902685932 1.0 1.0 5 Q15334 1 +Class b 2 secretin family receptors 0.6555150712156427 0.4351940595289473 0.6634215741419203 1.0 1.0 2 P63218 1 +Met activates pi3k akt signaling 0.6528651871480706 0.4274998389409532 0.6690153024119574 1.0 1.0 2 P62993 1 +Response of eif2ak1 hri to heme deficiency 0.6471172962226603 0.4262108485041319 0.6699542131672003 1.0 1.0 3 P05198,P08243 2 +Ire1alpha activates chaperones 0.327050427619065 0.4257210936390387 0.6703110897892415 1.0 1.0 24 O14773,P49748,O95070 3 +Cardiac conduction 0.3777237593201781 0.4169362901138186 0.6767250084901104 1.0 1.0 11 P05026,O43865,P23634,P16615 4 +Ion homeostasis 0.3777237593201781 0.4169362901138186 0.6767250084901104 1.0 1.0 11 P05026,O43865,P23634,P16615 4 +G2 m checkpoints 0.3075759001812668 0.4080569326493541 0.6832318775073154 1.0 1.0 76 Q9UQ84,P60900,P49720,P28070,P28074,Q7L590,P20618,P25788,O14757,Q13315,P49721,O43913,P40938,Q14566,Q9Y619 15 +Signaling by insulin receptor 0.3648444253416314 0.4077474008130715 0.6834591335914673 1.0 1.0 14 Q93050,P21281 2 +Diseases of immune system 0.6401171716410023 0.4074173615923366 0.6837014776492771 1.0 1.0 3 P09429 1 +Noncanonical activation of notch3 0.6455780059622478 0.4066855204396848 0.6842389765295349 1.0 1.0 2 Q92542 1 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.2944049048121207 0.4041243508096088 0.6861212792505822 1.0 1.0 64 O14949,Q9Y6M9,Q86Y39,P03886,P00403,P00846,O75964,Q9UDW1 8 +Coenzyme a biosynthesis 0.6439218284200154 0.4020268579544018 0.6876642602749423 1.0 1.0 2 Q9NVE7 1 +Global genome nucleotide excision repair gg ner 0.3284622693341888 0.3911175320958018 0.6957103620468812 1.0 1.0 37 P35244,Q7L5N1,P18074,Q9NRF9,Q9BT78,P28340,Q9UGN5,Q92905,Q99627,Q86WJ1,P12004,Q07864,P19447,P61088,P40938,P32780,P15927,P61201 18 +Pcna dependent long patch base excision repair 0.3517512734554818 0.3885370151541522 0.6976186672200997 1.0 1.0 17 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 +Fcgamma receptor fcgr dependent phagocytosis 0.3250973301555281 0.3773323195707071 0.705926656723808 1.0 1.0 30 Q8IV08,Q9UQB8 2 +Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.3197903924230971 0.3748286522163973 0.7077879038404618 1.0 1.0 46 P15880,Q13347,P20042,P46782,P62753,Q15056,O15372,P62701,P62244,P62266,Q9Y262,O75821,P62241,P05198,P62841,P62280,P62249,P23396,P46781,P08708,P62847,P62277,O00303,P46783,O75822,Q14240 26 +Dna replication 0.3103676479699691 0.3740946718363482 0.7083338826463685 1.0 1.0 82 P62191,P49720,O43242,P27694,P49643,Q7L590,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 37 +Formation of atp by chemiosmotic coupling 0.3667723341419758 0.3689738566625966 0.7121472113790153 1.0 1.0 11 P00846 1 +Estrogen dependent gene expression 0.321891644823189 0.3657993982419544 0.7145147689399638 1.0 1.0 28 Q9HCE1,Q15648,Q09472,Q99873,O15514,Q86X55,P30876 7 +Hemostasis 0.3510192955552744 0.3592001520517204 0.7194453628858464 1.0 1.0 126 P07602,Q9BVA1,Q13362,P04350,P42785,Q8NBX0,Q9NZJ7,Q9BUF5,Q13356,P05067,Q13509,P68371,Q13885 13 +Trna modification in the nucleus and cytosol 0.3664329877380248 0.3559088831743349 0.721908803027494 1.0 1.0 10 Q96PZ0,Q9NPF4,Q08J23 3 +Pi3k akt signaling in cancer 0.4062457148528227 0.3496201048757947 0.7266238205533218 1.0 1.0 7 P63000,O15111,P42345,P62993 4 +Rhod gtpase cycle 0.3188979562666427 0.3465319970807984 0.7289429418645448 1.0 1.0 28 Q9Y6M7,Q8TAA9,Q14739,P49257,O15173 5 +Rhobtb2 gtpase cycle 0.3404428304406504 0.3457924462241753 0.7294987024150157 1.0 1.0 18 P78371 1 +Mrna capping 0.3517194574417602 0.3301766743030019 0.7412664706684697 1.0 1.0 13 P32780,P30876 2 +Ephrin signaling 0.4686012510879231 0.3279629033663929 0.7429397115106449 1.0 1.0 4 O00560 1 +Formation of the early elongation complex 0.3370212808900421 0.3030524019564047 0.7618499271168104 1.0 1.0 16 P18615,O15514,P32780,P19447,P30876 5 +Cd28 dependent vav1 pathway 0.4580709313887847 0.2993973493788363 0.7646368843591702 1.0 1.0 4 P63000,P62993,P60953 3 +Signaling by fgfr2 iiia tm 0.3909699875392524 0.2982221877085286 0.765533588490249 1.0 1.0 7 P30876 1 +Fgfr2 mutant receptor activation 0.3909699875392524 0.2982221877085286 0.765533588490249 1.0 1.0 7 P30876 1 +Ripk1 mediated regulated necrosis 0.3501491911704114 0.2907049779216008 0.7712769641202846 1.0 1.0 10 O00560,Q8WUM4 2 +Pi5p regulates tp53 acetylation 0.4544581017736688 0.2898976789375816 0.7718945173580263 1.0 1.0 4 Q8TBX8 1 +Diseases of mitotic cell cycle 0.3359649174675828 0.2894970814931343 0.772201012957852 1.0 1.0 15 P11802,P30260,Q13042,Q00534,Q13309 5 +Class i mhc mediated antigen processing presentation 0.3192100678103114 0.2768784673970406 0.7818734269939358 1.0 1.0 101 Q96J02,P49720,O43242,Q8TBC4,Q13042,P60900,P28070,P30260,P20618,P19474,P49721,O94822,Q9UIQ6,O15111,Q15345,P09429,Q9NZ08,Q15436,P28074,P25788,Q15386,P52888 22 +Visual phototransduction 0.3837620231417714 0.2750833147293424 0.7832522301810327 1.0 1.0 7 P49356 1 +Regulation of beta cell development 0.5849323340176591 0.2741391417497273 0.7839776948267025 1.0 1.0 3 Q09472 1 +Diseases associated with glycosaminoglycan metabolism 0.3961032530996142 0.2680713179440255 0.7886444230315404 1.0 1.0 5 Q8NCH0 1 +Piwi interacting rna pirna biogenesis 0.3787857107400904 0.2595507572564224 0.7952103247334104 1.0 1.0 7 P30876 1 +Erks are inactivated 0.3782735318775416 0.2579731343249638 0.7964276413220217 1.0 1.0 7 Q8IV63,P27361,P30153 3 +P75ntr regulates axonogenesis 0.5770702044372241 0.2574995780455029 0.7967931409962785 1.0 1.0 3 Q9NQC3 1 +Raf independent mapk1 3 activation 0.3772768356709639 0.2557520607683827 0.7981422929393525 1.0 1.0 6 Q99956,P06493 2 +E3 ubiquitin ligases ubiquitinate target proteins 0.3217551774760639 0.2527753214716886 0.8004418391308301 1.0 1.0 18 O75150,Q14527,Q9BUN8,P12004,P50542 5 +Translesion synthesis by polk 0.3394417884871283 0.25027210440061 0.8023769276015762 1.0 1.0 10 P12004,P35244,P15927,P40938 4 +Signaling by notch1 pest domain mutants in cancer 0.3751903497903011 0.2485606170505947 0.8037006755395173 1.0 1.0 7 Q09472 1 +Activation of anterior hox genes in hindbrain development during early embryogenesis 0.3241578311212698 0.2437526912962673 0.8074223621235754 1.0 1.0 16 P30876,Q09472,P49711 3 +S phase 0.3007241545928803 0.2426175413483682 0.8083016911356173 1.0 1.0 86 P62191,P49720,O43242,P11802,P27694,P49643,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 37 +Wnt ligand biogenesis and trafficking 0.4320049605734612 0.2344889248338223 0.8146054302470256 1.0 1.0 4 Q9UBQ0 1 +Advanced glycosylation endproduct receptor signaling 0.3571463303101402 0.2330732248576508 0.8157045458559244 1.0 1.0 8 P47755,P09429,P05067 3 +Translesion synthesis by polh 0.3306831361362822 0.2317306151711109 0.8167472510637399 1.0 1.0 12 P12004,P40938,Q92890,P35244,P15927 5 +Lagging strand synthesis 0.3172543006228184 0.2212362733945835 0.8249084668571429 1.0 1.0 17 P28340,P27694,P12004,P40938,P09884,P35244,P15927 7 +Metabolism of carbohydrates 0.3063884213337545 0.2211329908707456 0.8249888830459531 1.0 1.0 94 P10253,Q9UBX3,P16278,Q8TB61,P54802,O43826,Q9BTX1,P08236,Q9BRR6,Q8NCH0,Q7LGA3 11 +Neutrophil degranulation 0.3655544275506028 0.2119068661104782 0.8321796938589752 1.0 1.0 162 P63167,P30519,P09960,P42785,Q14019,P08236,P10619,P68371,Q9BXS5,P16278,P04066,P20618,P07437,O43681,Q93050,Q9BTY2,P78371,P09429,O00560,Q4KMQ2,O15260,Q13510,P10253,P07602,Q9NZJ7,P15586,O00764 27 +P75 ntr receptor mediated signalling 0.3231702200399796 0.2111254809600667 0.83278935741398 1.0 1.0 13 P63000,Q92542,Q9NQC3,Q9H8V3,P52565 5 +Rna polymerase iii transcription initiation from type 1 promoter 0.3280135971456215 0.2094834065610284 0.8340708876752094 1.0 1.0 10 Q969F1,O14802 2 +Sars cov infections 0.2897507122128233 0.2055798677159815 0.8371191048518334 1.0 1.0 52 Q8WUX9,P07437,Q99720,Q99873 4 +Rho gtpases activate cit 0.3267780996055646 0.2052283421407574 0.8373937268742009 1.0 1.0 10 Q15334,P63000,P60660,Q15058 4 +Signaling by vegf 0.2984771056778997 0.2018438749393468 0.840038780157994 1.0 1.0 22 O43865,Q9UQB8 2 +Transport of vitamins nucleosides and related molecules 0.3579203921685875 0.1986146805225948 0.8425641690007606 1.0 1.0 7 Q8TB61 1 +Pp2a mediated dephosphorylation of key metabolic factors 0.545533485177593 0.1971684039318013 0.8436957552601769 1.0 1.0 3 P30153 1 +Signaling by fgfr2 in disease 0.3319023033039641 0.1934008180322335 0.8466450748323042 1.0 1.0 9 P30876 1 +Neurexins and neuroligins 0.3422093697650473 0.1879880363085092 0.8508860296267364 1.0 1.0 8 Q15334 1 +Mastl facilitates mitotic progression 0.3649283779404519 0.1878434358157388 0.8509993849344935 1.0 1.0 5 P30153,P14635,P06493 3 +Recycling of eif2 gdp 0.3509650973234269 0.1798901230065893 0.8572388294094218 1.0 1.0 7 Q9NR50,Q14232,Q13144,P05198,P49770 5 +Abortive elongation of hiv 1 transcript in the absence of tat 0.3160192669288543 0.1774808564701704 0.85913070085223 1.0 1.0 12 P18615,O15514,P30876 3 +Synthesis of udp n acetyl glucosamine 0.3601529491275274 0.1768945557331663 0.8595912150806113 1.0 1.0 5 Q9UJ70 1 +Transcriptional regulation by runx1 0.2706008659915087 0.1765542504750017 0.8598585322672583 1.0 1.0 64 Q96J02,Q9HCE1,Q09472,P49720,P28070,P60900,Q99873,P28074,P25788,P20618,Q16625,Q00534,P49721 13 +Constitutive signaling by overexpressed erbb2 0.4032614807970777 0.1732532056811716 0.86245240383325 1.0 1.0 4 P07900 1 +Suppression of apoptosis 0.4030171559710731 0.1727813236670508 0.8628233177983342 1.0 1.0 4 P23246,P14373 2 +Met activates ptpn11 0.5307945788355264 0.1725884459882111 0.8629749343748054 1.0 1.0 3 P62993 1 +Base excision repair 0.2899095588404833 0.1606558952049275 0.8723644286244312 1.0 1.0 30 Q96T60,Q9NRF9,P28340,Q9UGN5,P12004,P40938,P29372,Q15554,P15927 9 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.3944315545243506 0.156729197376174 0.8754582752658993 1.0 1.0 4 Q14738,P30153,P30154 3 +Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.3400085824160395 0.1565931818679384 0.8755654763319205 1.0 1.0 6 Q9UKZ1 1 +Irak1 recruits ikk complex 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 +Ikk complex recruitment mediated by rip1 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 +Ticam1 rip1 mediated ikk complex recruitment 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 +Downregulation of smad2 3 smad4 transcriptional activity 0.3478116710875368 0.1503214431725288 0.8805110160025145 1.0 1.0 5 Q93008,P09874,Q9UPN9,Q13547 4 +Irs mediated signalling 0.5102717031146418 0.1422442444420197 0.8868870850620827 1.0 1.0 3 Q99570,P62993 2 +Frs mediated fgfr3 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr2 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Tie2 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Frs mediated fgfr1 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr3 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr1 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Frs mediated fgfr2 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Frs mediated fgfr4 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr4 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Stat5 activation downstream of flt3 itd mutants 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Stat5 activation 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Activated ntrk2 signals through frs2 and frs3 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Signaling by flt3 itd and tkd mutants 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Cyclin d associated events in g1 0.3018691720118506 0.1273641298180887 0.8986522052454764 1.0 1.0 11 Q13616,P11802,Q00534,Q13309,P30153 5 +G beta gamma signalling through cdc42 0.5084465054653999 0.1262933294702367 0.899499736293581 1.0 1.0 2 P63218 1 +Polymerase switching 0.2999083193806568 0.1234400041664036 0.9017586805446204 1.0 1.0 12 P09884,P12004,P40938,P28340 4 +N glycan antennae elongation in the medial trans golgi 0.4902889478628819 0.1169858639721942 0.9068712554745147 1.0 1.0 3 P04066 1 +Nervous system development 0.3776066495452238 0.1076888822682559 0.9142424888883656 1.0 1.0 194 Q9Y3U8,P49720,O43242,Q9BVA1,P07900,P32969,P39023,Q01518,Q16850,Q15334,O15145,P60660,Q9BPU6,P68371,P46776,Q13885,O14786,P60900,P28070,P50552,P27635,Q12955,P18621,P04350,Q7Z460,P20618,Q96CW1,P46782,P07737,Q9NR77,P49721,Q92542,Q02543,P62701,P62244,P62917,P83731,P62266,P46779,Q02878,Q9BUF5,P61313,P62241,P62841,P46778,O00560,Q13509,P18077,Q13617,P28074,P61254,P25788,P08708,Q96S59,P83881 55 +P75ntr negatively regulates cell cycle via sc1 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 1.0 2 Q13547 1 +Pten regulation 0.2591210234965989 0.104180204168575 0.9170263432631672 1.0 1.0 61 Q9HCE1,P60900,P49720,O43242,P28070,P42345,P28074,P25788,P20618,P49721 10 +Regulation of tp53 activity through methylation 0.3175691297461373 0.1018938233227505 0.9188409527203778 1.0 1.0 7 Q09472 1 +Rhoq gtpase cycle 0.2825845350143573 0.0995085997591814 0.9207344601706248 1.0 1.0 20 Q9Y6M7,Q15642,Q68EM7,Q8TAA9 4 +Rac3 gtpase cycle 0.2792539668588933 0.0927449036225325 0.9261062227891984 1.0 1.0 32 Q8TAA9,Q9UQB8,Q14739,P49257,O15173 5 +Respiratory electron transport 0.2731275853303941 0.0917936999030121 0.9268619496787224 1.0 1.0 53 O75880,Q9Y6M9,Q86Y39,P03886,P00403,O14949,Q9UDW1 7 +Cell surface interactions at the vascular wall 0.2852802633494709 0.0908715808127838 0.9275946319664856 1.0 1.0 17 P35613,Q9UPY5,Q13356,Q92896,P53985 5 +Bile acid and bile salt metabolism 0.3137308256114017 0.0900547791062246 0.9282436841908828 1.0 1.0 5 P22059 1 +Synthesis of bile acids and bile salts 0.3137308256114017 0.0900547791062246 0.9282436841908828 1.0 1.0 5 P22059 1 +Regulation of localization of foxo transcription factors 0.4602385685884633 0.0866045433125212 0.9309858544312192 1.0 1.0 3 P31946,P63104 2 +Mitotic spindle checkpoint 0.2750244449323438 0.0860958244060395 0.9313902429422928 1.0 1.0 51 P63167,Q13362,Q7Z460,Q13042,P43034,Q13257,Q9P258 7 +Wax and plasmalogen biosynthesis 0.3463705667881979 0.0858335086637746 0.9315987687025276 1.0 1.0 4 Q6IAN0,O00116,Q8WVX9 3 +Pentose phosphate pathway 0.3048092868988342 0.0851742497188798 0.9321228619208866 1.0 1.0 6 P52209,Q96G03,P11413,P29401,O95336 5 +Aflatoxin activation and detoxification 0.4624047697913376 0.0816543738883752 0.9349215615036572 1.0 1.0 2 O14880 1 +Amino acid transport across the plasma membrane 0.3410672853828277 0.07992326259649 0.9362982881336646 1.0 1.0 4 Q9H2H9,P08195,Q9UPY5 3 +Miro gtpase cycle 0.2960875331565011 0.0663176540885294 0.9471249282347254 1.0 1.0 5 O95140,Q8IWA4,P52306,Q8IXI1 4 +M phase 0.3611035325825698 0.063455579245693 0.9494037305446889 1.0 1.0 178 Q9H6D7,P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q86XL3,Q9BUF5,P07437,P49721,Q9BTX1,Q8WUX9,Q13509,P68371,Q13885 17 +Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0.426495293051693 0.062312675839974 0.9503138342338812 1.0 1.0 3 O14786 1 +Processing of dna double strand break ends 0.2680415270631722 0.0604265981088138 0.9518158751314454 1.0 1.0 22 Q9UQ84,O14757,Q13315,P40938,Q9UNS1,P15927 6 +Zbp1 dai mediated induction of type i ifns 0.3191912495856762 0.0592391478995165 0.95276162886241 1.0 1.0 4 Q08211,Q9NZI8,O15111 3 +Rip mediated nfkb activation via zbp1 0.319191249585676 0.0592391478995165 0.95276162886241 1.0 1.0 4 Q08211,O15111,Q9NZI8 3 +Inositol phosphate metabolism 0.2871352785145901 0.0561233339385807 0.9552435554370162 1.0 1.0 5 Q01968,Q9BW91,Q9NPH2,Q9UNW1 4 +Signaling by erbb2 ecd mutants 0.2871352785145883 0.0561233339385788 0.9552435554370178 1.0 1.0 5 P62993,Q96RT1,P07900,Q16543 4 +Signaling by erbb2 in cancer 0.2871352785145883 0.0561233339385788 0.9552435554370178 1.0 1.0 5 P62993,Q96RT1,P07900,Q16543 4 +Nucleotide salvage 0.2883211678832167 0.0503782226168225 0.959820990180648 1.0 1.0 7 Q9BZX2,P00491,P00492,P07741,P55263,Q08623 6 +Tp53 regulates transcription of death receptors and ligands 0.394501490559802 0.0498388196655772 0.960250831486906 1.0 1.0 2 P49327 1 +Oas antiviral response 0.393969516235911 0.0470658698564479 0.9624607290866314 1.0 1.0 3 P61221,Q6L8Q7 2 +Protein ubiquitination 0.2628524335738891 0.0426984142065389 0.965941943698344 1.0 1.0 27 O75150,Q14527,Q9BUN8,P12004,P50542,P61088 6 +Glycerophospholipid catabolism 0.3256045048029257 0.040641975142977 0.9675813204596306 1.0 1.0 2 Q8N9F7 1 +Polb dependent long patch base excision repair 0.2813727423686923 0.0404245089626096 0.9677546908896596 1.0 1.0 7 Q9UGN5,P27695,P09874,Q86W56 4 +Synthesis of ip3 and ip4 in the cytosol 0.2868499503146861 0.0394562234305353 0.9685266549591712 1.0 1.0 2 Q01968 1 +Signaling by retinoic acid 0.2681787047191667 0.0358333155023457 0.9714152681880248 1.0 1.0 12 Q9BTZ2,O00330,Q15120,Q9HBH5 4 +Signaling by ptk6 0.2673506149120848 0.0349339138108509 0.9721324377986782 1.0 1.0 9 P11802,P63000,Q07666 3 +Tight junction interactions 0.3343273691186175 0.0335363916426276 0.9732468458095058 1.0 1.0 3 Q8NI35,Q8N3R9 2 +Rna polymerase iii chain elongation 0.275107722903538 0.0331675328424117 0.9735409889086092 1.0 1.0 4 O14802,Q9BUI4,P62875 3 +Rna polymerase iii transcription initiation from type 3 promoter 0.275107722903538 0.0331675328424117 0.9735409889086092 1.0 1.0 4 O14802,Q9BUI4,P62875 3 +Displacement of dna glycosylase by apex1 0.3207422133863425 0.0321391535934674 0.9743610794742912 1.0 1.0 3 P27695,P29372 2 +Regulation of bach1 activity 0.2887274277090861 0.0302202027243674 0.975891436444817 1.0 1.0 3 Q13309 1 +Pyrimidine salvage 0.2879390324718301 0.0301907611396797 0.9759149167168792 1.0 1.0 3 Q9BZX2,Q08623 2 +Dap12 interactions 0.2869449966865412 0.0301545833642398 0.9759437692688162 1.0 1.0 3 P63000,P62993 2 +Dap12 signaling 0.2869449966865412 0.0301545833642398 0.9759437692688162 1.0 1.0 3 P63000,P62993 2 +Signaling by fgfr 0.2560151083555537 0.0232116051821363 0.98148148150561 1.0 1.0 23 O43251,O15514,P30876 3 +Signaling by fgfr2 0.2560151083555537 0.0232116051821363 0.98148148150561 1.0 1.0 23 O43251,O15514,P30876 3 +Ksrp khsrp binds and destabilizes mrna 0.2624795885042132 0.0184933227271386 0.9852453043478586 1.0 1.0 14 Q9NQT4,Q15024,Q92945 3 +Atf4 activates genes in response to endoplasmic reticulum stress 0.2594428533602185 0.0110104996406288 0.9912150698315034 1.0 1.0 14 Q9NQT4,Q15024,Q92945 3 +Perk regulates gene expression 0.2602199510365197 0.0102372342173709 0.9918320115417308 1.0 1.0 16 Q9Y3B2,Q9NQT4,Q15024,Q8IU60,Q9Y2L1,P05198,Q92945,Q9NQT5,Q96B26,P08243 10 +Semaphorin interactions 0.2590296042660046 0.008393395904603 0.9933031176266538 1.0 1.0 19 P60660,Q9BPU6,O14786,P07900 4 +Signaling by erbb4 0.2501593059712398 0.0051321763886379 0.9959051336721374 1.0 1.0 8 Q96J02,Q15334 2 +Trafficking of ampa receptors 0.2465843128702768 0.0013165346701444 0.9989495576163788 1.0 1.0 8 Q15334 1 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0554bebd465383a9d1de4ebeef65585abed79150 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through pi3k", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Ampk inhibits chrebp transcriptional activation activity", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd22 mediated bcr regulation", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Cgmp effects", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Common pathway of fibrin clot formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective b4galt1 causes b4galt1 cdg cdg 2d", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective ext2 causes exostoses 2", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythropoietin activates phosphoinositide 3 kinase pi3k", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Erythropoietin activates stat5", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acids bound to gpr40 ffar1 regulate insulin secretion", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fertilization", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling by cbl mutants", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of cell death genes", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interaction with cumulus cells and the zona pellucida", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nitric oxide stimulates guanylate cyclase", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Ptk6 regulates rtks and their effectors akt1 and dok1", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine catabolism", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of fzd by ubiquitination", "Regulation of gene expression by hypoxia inducible factor", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx2 regulates bone development", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is proteolytically processed", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of gdp mannose", "Synthesis of glycosylphosphatidylinositol gpi", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANO10", "ANO6", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATRX", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDK", "BCL10", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOP1", "BPHL", "BPNT1", "BRD2", "BRD4", "BSG", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKAL1", "CENPF", "CENPU", "CERS2", "CETN2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLINT1", "CLTC", "CMAS", "CMBL", "CMPK1", "CNDP2", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "COASY", "COG1", "COG3", "COG8", "COL4A3BP", "COLGALT1", "COMMD2", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ9", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CWC27", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS4", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJB11", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPH2", "DPH5", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DSC2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM49B", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNTB", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP3", "GUSB", "GYG1", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILK", "IMMT", "IMP3", "IMP4", "IMPDH2", "INCENP", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS9", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JMJD6", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP2", "LPCAT1", "LPGAT1", "LRPPRC", "LRRC1", "LRRC41", "LRRC8A", "LRRC8C", "LRSAM1", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MAD2L1", "MAGED2", "MAIP1", "MAN2A1", "MAN2B1", "MANF", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MARC1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "METAP1", "METAP2", "MFGE8", "MFN1", "MFN2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO1E", "MYO5A", "MYO6", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCSTN", "ND1", "NDC1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEO1", "NFS1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF8", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA6", "PNPLA8", "POFUT1", "POGLUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIE", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS1", "PUS7", "PVR", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBFOX2", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOX2", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP7A", "RRP8", "RSF1", "RSU1", "RTCB", "RTKN", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SARNP", "SARS", "SARS2", "SART1", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35B2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STT3A", "STUB1", "STX18", "STX3", "STXBP2", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE2", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAP1", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCC", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TECR", "TERF2", "TERF2IP", "TEX10", "TFAM", "TFB1M", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMED7", "TMED9", "TMEM30A", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNPO1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM3", "TPMT", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRMT10C", "TRMT11", "TRMT6", "TRMU", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TST", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXN2", "TXNDC5", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBR2", "UBR4", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC119B", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS36", "VPS37B", "VPS37C", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WBP11", "WDCP", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WNK2", "WTAP", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AAMP", "AASDHPPT", "ABCB1", "ABCE1", "ABHD10", "ABRAXAS2", "ACADVL", "ACAT2", "ACBD3", "ACOT7", "ACP6", "ADD1", "ADK", "ADPGK", "ADSL", "ADSS", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "ALDH3A2", "ALG11", "ANAPC5", "ANK3", "ANKLE2", "ANO6", "AP1M1", "AP1S2", "AP2M1", "AP3S1", "APEX1", "APOOL", "APP", "APRT", "ARHGAP17", "ARHGDIA", "ARPC3", "ASAH1", "ASNA1", "ASNS", "ATG9A", "ATM", "ATP13A1", "ATP1B1", "ATP2A2", "ATP2B4", "ATP5L", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V1B2", "B4GALT1", "BAG6", "BAIAP2", "BPHL", "BRD2", "BSG", "BUB3", "CADM1", "CALU", "CAP1", "CAPZA2", "CARM1", "CCNB1", "CCT2", "CDC16", "CDC27", "CDC37", "CDC42", "CDK1", "CDK4", "CDK6", "CENPF", "CERS2", "CHD1L", "CHEK1", "CHKA", "CHMP7", "CHST14", "CHUK", "CLASP1", "CLINT1", "CNDP2", "CNOT11", "CNOT2", "COL4A3BP", "COPE", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COTL1", "COX2", "CPT2", "CTBP1", "CTCF", "CTH", "CTSA", "CUL1", "CUL2", "CYB5B", "CYP51A1", "DCAF7", "DCP2", "DCTN4", "DCUN1D1", "DCUN1D5", "DERL1", "DERL2", "DHCR24", "DHFR", "DHPS", "DHRS4", "DHRS7B", "DHX9", "DIS3", "DOLPP1", "DPYSL5", "DUSP9", "DYNLL1", "DYNLL2", "ECE1", "ECT2", "EEF1A2", "EEF1D", "EEF1E1", "EEF1G", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4A2", "EIF4H", "EIF5", "ENDOD1", "EP300", "EPHX1", "ERAP1", "ERBIN", "ERCC2", "ERCC3", "EXO1", "EXOSC1", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC8", "FADS2", "FAM49B", "FAR1", "FASN", "FNTB", "FUCA1", "FUCA2", "G6PD", "GAA", "GART", "GBA", "GBF1", "GCLM", "GDPD1", "GGCX", "GINS3", "GLA", "GLB1", "GLG1", "GMPPB", "GNE", "GNG5", "GNS", "GOLIM4", "GRB2", "GSR", "GSTO1", "GTF2H1", "GTF3C6", "GUSB", "GYG1", "HAGH", "HAUS4", "HDAC1", "HLTF", "HMGB1", "HMOX1", "HMOX2", "HPRT1", "HS2ST1", "HSP90AA1", "HTT", "ICMT", "IGF2BP1", "IGF2R", "ISYNA1", "ITCH", "KDELR1", "KDM1B", "KHDRBS1", "KHSRP", "KIF14", "KIF5B", "KYAT3", "LAMP2", "LARS", "LBR", "LGALS3BP", "LLGL1", "LMAN1", "LNPEP", "LRRC41", "LTA4H", "LTN1", "M6PR", "MAD2L1", "MAPK3", "MBOAT7", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MED1", "MFN1", "MFN2", "MGST3", "MICU1", "MINPP1", "MMGT1", "MMS19", "MORC2", "MOV10", "MPG", "MPP2", "MPP5", "MSH2", "MSH6", "MSMO1", "MTAP", "MTCH1", "MTMR6", "MTOR", "MTX1", "MYL6", "NAGK", "NAGLU", "NAMPT", "NCEH1", "NCSTN", "ND1", "NDC1", "NDUFA11", "NDUFB9", "NECAP1", "NECAP2", "NELFE", "NPC1", "NPEPPS", "NRP1", "NSUN2", "NUBP2", "NUDT9", "OCLN", "OCRL", "ORC5", "OSBP", "OSGEP", "OTUB1", "PAFAH1B1", "PAFAH1B3", "PANK4", "PAPSS1", "PARG", "PARL", "PARP1", "PARP2", "PATJ", "PCNA", "PDCD4", "PDCD6IP", "PDE12", "PDHX", "PDK3", "PDXK", "PEBP1", "PEX5", "PFN1", "PFN2", "PGD", "PGLS", "PGM2", "PGRMC2", "PIK3C2A", "PIK3R4", "PIP4K2C", "PITPNB", "PITRM1", "PLA2G15", "PLD3", "PLK1", "PNKP", "PNP", "POLA1", "POLD1", "POLE", "POLE3", "POLR2B", "POLR2D", "POLR2L", "POLR3A", "POLR3C", "POM121C", "PON2", "POR", "PPAT", "PPIL2", "PPP2R1A", "PPP2R1B", "PPP2R5C", "PPP2R5D", "PPT1", "PRCP", "PRIM2", "PRMT1", "PSAP", "PSMA1", "PSMA2", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMC1", "PSMC6", "PSMD10", "PSMD14", "PSMD3", "PSMD7", "PSME2", "PTDSS1", "PTPMT1", "PTPRF", "PUDP", "PUS7", "PXMP2", "RAB3GAP1", "RAC1", "RAN", "RANBP9", "RAP1GDS1", "RAPGEF2", "RBFOX2", "RCC2", "RDH14", "RFC3", "RHOT2", "RNF40", "RPA1", "RPA2", "RPA3", "RPL10", "RPL12", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL24", "RPL26", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL35A", "RPL36", "RPL36A", "RPL37A", "RPL4", "RPL5", "RPL6", "RPL8", "RPL9", "RPS10", "RPS11", "RPS13", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS2", "RPS23", "RPS24", "RPS3", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RTN3", "RTN4", "SAMM50", "SCARB1", "SCARB2", "SCCPDH", "SCO1", "SDCBP", "SEC11A", "SEC23A", "SEH1L", "SFPQ", "SGPL1", "SIGMAR1", "SKP2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC29A1", "SLC35B2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SNX2", "SNX9", "SPCS2", "SPR", "SPTLC1", "SQLE", "SRP9", "SRPRB", "SSR1", "STAMBP", "SURF4", "TACC3", "TECR", "TERF2", "TFRC", "THOP1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TKT", "TOMM22", "TOMM5", "TPP1", "TRAM1", "TRAPPC4", "TRIM21", "TRIM27", "TRIM33", "TRIP10", "TSN", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TXNL1", "UBA3", "UBE2N", "UBE3C", "UBXN7", "UCK2", "UFD1", "UGCG", "UGT8", "UNC119B", "UQCR10", "UQCRQ", "USP11", "USP15", "USP19", "USP47", "USP48", "USP9X", "VANGL1", "VASP", "VDAC1", "VDAC2", "VDAC3", "VPS29", "VPS37C", "VRK3", "WNK2", "XRN2", "YIF1A", "YWHAB", "YWHAE", 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pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Alzheimers disease 15 77 3.529141219839798 0.0004169105893609 18.929611650485437 83.0752427184466 0.8523996335219438 0.5089902911900335 9.09856474570077 6.061710858604258 1.0800674607776464 0.3865214102951685 0.0001575744049636 0.0002928873564107 1.7665359281132017e-05 5.561704803411426e-06 8.291763292541703e-05 +Alzheimers disease and mirna effects 17 79 3.4655870761610736 0.0005290751695681 19.78640776699029 84.62864077669903 0.8675405351918691 0.5019659822826982 9.06411947478317 6.212690980603589 1.0744065053186531 0.3869842050583563 0.0001712004889851 0.0003178174093563 2.0153218532450628e-05 1.6018255607448903e-06 1.2730262552320422e-05 +Pathogenic escherichia coli infection 6 24 3.240621548893338 0.0011926941213447 8.04368932038835 23.04126213592233 -0.1828642907559088 0.5748742925026463 4.5754764175075255 2.330828920267767 0.9569379411043492 0.3191018272971252 3.60354480543106e-05 5.591060906738053e-05 2.054752948225633e-07 9.536310572418432e-05 0.0002699095083601 +Parkinubiquitin proteasomal system pathway 6 35 2.9921437617294693 0.0027702577408541 15.601941747572816 35.157766990291265 -0.325879167431566 0.536922604645563 7.590668525024711 1.7465257785732904 1.1836499766651585 0.3562945902068221 9.861226807985836e-05 0.0001522275157388 1.2296564334831526e-06 0.0004830692131202 0.006819962442172 +Cholesterol metabolism with bloch and kandutschrussell pathways 6 21 2.404583308102552 0.0161909154143855 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 0.1449957667029796 0.1604648724397155 0.048990890514732 0.001886473535207 0.0018239004417557 +Sphingolipid metabolism in senescence 4 11 2.2455956963044668 0.0247299164036776 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 0.0927245527266703 0.1029565435856987 0.0202898922491691 0.0001921663686867 7.864188206340052e-05 +Folate metabolism 1 14 2.20002606684743 0.0278050456584271 2.9223300970873787 14.66504854368932 0.4885827184030638 0.4716393281670001 2.01903235685469 1.6964960312512605 0.9273691097933516 0.2947258147319118 0.0089475442467942 0.0110614955842043 0.0420348553288257 0.2000228109389489 0.4999873679723159 +Ferroptosis 3 21 2.196241967127232 0.0280746290136071 6.247572815533981 23.589805825242717 0.9586016481897424 0.3324276931898122 2.8577723913591164 2.1450310521583007 1.2134257594151 0.3161491716459103 0.0194375447241864 0.0238997911322505 0.08610744549237 0.126862428798268 0.2373860395762566 +Disorders of folate metabolism and transport 0 7 2.131026907412118 0.0330869255237415 2.1407766990291264 7.405339805825243 0.2461758429428204 0.4865736310743483 1.8887987086471552 0.7460384897720235 1.0129661604612583 0.3045362782095057 0.0494766335272643 0.0550816697898294 0.1094892401774078 0.2559514735144251 0.451869757084416 +Metapathway biotransformation phase i and ii 5 22 2.030457226565195 0.0423100847733195 5.674757281553398 21.74757281553398 1.0367643596879972 0.3247805075973627 2.26648088910968 1.8784337960788755 0.9302956939670612 0.2816826074355951 1.0 1.0 0.1132051672598368 0.0032541277976547 0.0714987291280259 +Mevalonate pathway 0 5 1.9839138687424644 0.0472654425755525 1.7597087378640777 5.012135922330097 -0.1447169660190723 0.4866950102694206 1.2952594344551245 0.9938394221699504 0.9826093950654556 0.2885570749953845 0.0291589623518842 0.0325017468768143 0.0653907127050202 0.1583736196074974 0.295760276625992 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..06bcf6ed23b9042d18b024db513dfd1d07292b4f --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 589, + "title": "Average number of proteins per term", + "value": 9.98471986417657 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..dd938173d9da6f92cf7becad1ff315786a368b28 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..91c829e2754e0273b43435aea3e5306f0e56908b --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,175 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Alzheimers disease 0.6201101630767539 3.529141219839798 0.0004169105893609 0.2177739703421758 0.1558126374378137 77 P21796,P60900,P45880,P49720,Q9BVA1,P28070,P04350,P20618,Q9BUF5,P07437,P05067,P49721,Q13509,P68371,Q13885 15 +Alzheimers disease and mirna effects 0.6152663262646862 3.4655870761610736 0.0005290751695681 0.2678045119969069 0.1558126374378137 79 P21796,P60900,P45880,P49720,Q9BVA1,P28070,P04350,O95197,P20618,Q9BUF5,P07437,P05067,P49721,Q9NQC3,Q13509,P68371,Q13885 17 +Pathogenic escherichia coli infection 0.7488195665477883 3.240621548893338 0.0011926941213447 0.504860680658856 0.2341656124906775 24 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Parkinubiquitin proteasomal system pathway 0.681159761719462 2.9921437617294693 0.0027702577408541 0.8048420565115002 0.3263363618726194 35 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.6554703632672622 2.404583308102552 0.0161909154143855 0.999933245888375 0.5298027321707273 21 Q9BWD1,Q14534,Q15800,Q16850,Q15392,Q14739 6 +Sphingolipid metabolism in senescence 0.7423463058425988 2.2455956963044668 0.0247299164036776 0.99999960684162 0.5602277216063889 11 Q16739,P16278,Q96G23,P04062 4 +Folate metabolism 0.6982124337364684 2.20002606684743 0.0278050456584271 0.999999938802924 0.5868115449498627 14 P00374 1 +Ferroptosis 0.6207525802243774 2.1962419671272317 0.0280746290136071 0.9999999480256212 0.5868115449498627 21 P09601,P45880,P16435 3 +Metapathway biotransformation phase i and ii 0.5818378723978038 2.030457226565195 0.0423100847733195 0.9999999999912608 0.6372789416154411 22 P07099,Q16850,Q8NCH0,P78417,Q7LGA3 5 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.911597818429665 1.9861524778105828 0.0470163957552669 0.99999999999952 0.6372789416154411 4 P07099,P09601 2 +Nephrotic syndrome 0.6740491751451765 1.913084049674703 0.0557372933536211 0.999999999999998 0.6372789416154411 11 Q14108 1 +Retinoblastoma gene in cancer 0.500567061675432 1.8949125754633311 0.0581039848612621 0.9999999999999996 0.6372789416154411 45 P00374,Q14527,P11802,O14757,P06493,P12004,P26358,Q07864,Q00534,P40938,P52701,P09429,Q14566,Q9Y619,P26583,P15927 16 +Ethanol effects on histone modifications 0.6690921946794909 1.8884815791243976 0.0589613285982104 0.9999999999999996 0.6372789416154411 11 P00374 1 +Sphingolipid pathway 0.665579166202539 1.8710085772297844 0.0613438921628102 1.0 0.6372789416154411 11 P04062,O95470,Q16739,Q96G23,Q9Y5P4,Q13510 6 +Onecarbon metabolism and related pathways 0.6438113268942754 1.8617938191409344 0.0626321580703457 1.0 0.6372789416154411 13 P35790,O15382,P00390,O43865 4 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.6397572031158647 1.8406891571460833 0.0656671237894213 1.0 0.6372789416154411 13 O60725,O75844 2 +Vitamin dsensitive calcium signaling in depression 0.754896489066853 1.8177010894537795 0.0691098311526894 1.0 0.6372789416154411 6 Q8NB78 1 +Copper homeostasis 0.7583895506595532 1.703099285789007 0.0885494895869398 1.0 0.7496944279521571 5 P05067 1 +Ketogenesis and ketolysis 0.7218454081121635 1.6753591593094448 0.0938637846093659 1.0 0.7496944279521571 6 P23786,O43772 2 +H19 action rbe2f1 signaling and cdkbetacatenin activity 0.7504976783291696 1.6700564309801886 0.0949081992094151 1.0 0.7496944279521571 5 P11802,Q15648 2 +Statin inhibition of cholesterol production 0.8249313258890734 1.649781220966585 0.0989876909870863 1.0 0.7496944279521571 4 Q8WTV0 1 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.74380769245056 1.6419848296630284 0.1005931480367756 1.0 0.7496944279521571 5 P09601,P48507 2 +Base excision repair 0.5737218700866771 1.63137776116096 0.1028106344416002 1.0 0.7496944279521571 16 Q96T60,Q9NRF9,P28340,Q9UGN5,P12004,P09429,P29372 7 +Glycosaminoglycan degradation 0.7113289149298622 1.629725742613347 0.1031594741434158 1.0 0.7496944279521571 6 P16278,P54802,P08236 3 +Notch signaling 0.7381216767897676 1.6180837692530117 0.1056445458744126 1.0 0.7496944279521571 5 P56545,Q13363 2 +Metabolism of spingolipids in er and golgi apparatus 0.7068883359890674 1.6104114253900348 0.1073080679554581 1.0 0.7524339526876764 6 O95470,Q16739,Q16880 3 +Nrf2are regulation 0.6850772456676195 1.5343231022074006 0.1249501850122851 1.0 0.777653379775988 7 P09601 1 +Cholesterol biosynthesis with skeletal dysplasias 0.7172921865122495 1.5302224172230794 0.1259616843428008 1.0 0.777653379775988 5 Q16850,Q15392 2 +Transcriptional activation by nrf2 in response to phytochemicals 0.7868743785217042 1.499723203887435 0.1336861173575358 1.0 0.777653379775988 4 Q13155,P48507,P09601 3 +Camkk2 pathway 0.5988969632393502 1.4926524128815275 0.1355281959506755 1.0 0.777653379775988 10 Q09472,P09601 2 +Oxidation by cytochrome p450 0.7082558835454603 1.491972463676655 0.1357063642420759 1.0 0.777653379775988 5 Q16850,O43169 2 +Transsulfuration and onecarbon metabolism 0.5307622420629926 1.4692945257880268 0.1417529209755237 1.0 0.777653379775988 18 P00374,O43865 2 +Intraflagellar transport proteins binding to dynein 0.6706307286198202 1.4518130311439454 0.1465535995585516 1.0 0.777653379775988 6 P63167,Q8NCM8,Q9BW83,Q96FJ2 4 +Kennedy pathway from sphingolipids 0.7702424694684898 1.4338477644749337 0.15161571101559 1.0 0.777653379775988 4 O95470,P35790 2 +Phosphoinositides metabolism 0.6623041286142967 1.4335387378394464 0.1517039366847754 1.0 0.777653379775988 7 O00443,Q8TBX8 2 +Exerciseinduced circadian regulation 0.536732813563912 1.4195817784789322 0.1557294733143803 1.0 0.7839714511296585 16 Q93062 1 +7oxoc and 7betahc pathways 0.6556058342028507 1.4037950702392157 0.1603798823892133 1.0 0.7912589506974899 7 O00154,O15118,Q9Y305 3 +Influence of laminopathies on wnt signaling 0.5988377478703211 1.3821250815844706 0.1669332984579581 1.0 0.7912589506974899 9 O60725,Q00534,O75844 3 +Vitamin d receptor pathway 0.5604938444597302 1.376343031369454 0.1687154563718766 1.0 0.7912589506974899 12 Q96KA5 1 +Sphingolipid metabolism overview 0.6199794119938625 1.3601918279178584 0.1737692279480662 1.0 0.7912589506974899 8 O95470,Q16739,Q96G23,Q13510 4 +Sphingolipid metabolism integrated pathway 0.6199794119938625 1.3601918279178584 0.1737692279480662 1.0 0.7912589506974899 8 O95470,Q16739,Q96G23,Q13510 4 +Nitric oxide metabolism in cystic fibrosis 0.7484255883327751 1.3472741563356427 0.17789195229102 1.0 0.7912589506974899 4 Q86X55,O60678,Q99873 3 +Autophagy 0.6423570819597706 1.344857132408411 0.1786713759639493 1.0 0.7912589506974899 7 Q9NT62,P42345,Q9Y4P8,Q7Z3C6 4 +Dna damage response only atm dependent 0.5136022863719235 1.3234320421833703 0.1856917419400718 1.0 0.7947564152138796 17 P09429,Q13362,O00443 3 +Dna mismatch repair 0.5065098392361712 1.3226872657699382 0.1859394000727374 1.0 0.7947564152138796 18 Q9UQ84,Q9NRF9,P28340,P12004,Q07864,P52701,P40938,P15927 8 +Ccl18 signaling pathway 0.5574043157708343 1.319820873660123 0.1868948307001607 1.0 0.7947564152138796 11 P33176,Q09472,Q86UE4,Q96GC9,P00403 5 +Male infertility 0.4720650045034312 1.3097266708354949 0.190288317631126 1.0 0.7947564152138796 22 P08183,Q15165,Q9UHI6,Q09472 4 +Nad biosynthetic pathways 0.738813163485784 1.309102512977489 0.1904996281459996 1.0 0.7947564152138796 4 P43490 1 +Proteoglycan biosynthesis 0.909542929452808 1.2979521575142412 0.1943037755361607 1.0 0.7947564152138796 3 Q8TB61 1 +Endothelin pathways 0.6038872343219722 1.2854036318672886 0.1986512727285339 1.0 0.80140821669251 8 P42892 1 +Nucleotidebinding oligomerization domain nod pathway 0.5485041871293639 1.237280316715181 0.215983032700366 1.0 0.8299201672804531 10 Q13685,P07900,P63000,O15111,P55210 5 +Hijack of ubiquitination by sarscov2 0.7206351436376257 1.2369308981403146 0.2161127378852576 1.0 0.8299201672804531 4 Q8TBC4 1 +Purine metabolism 0.6142049033659043 1.2193078453923156 0.222727372029619 1.0 0.8463640137125523 7 P30566,Q9BY32,P30520 3 +Mitochondrial complex iii assembly 0.5565677238399049 1.1767416972217757 0.239298619575849 1.0 0.8838213003125561 9 O14949 1 +Aryl hydrocarbon receptor pathway wp2873 0.6038013087400794 1.1569467258329464 0.2472941267267854 1.0 0.8873017157885454 6 Q15185,Q09472,O00170 3 +Adipogenesis 0.5258369577481495 1.1557164286395876 0.2477971660528912 1.0 0.8873017157885454 11 O75844 1 +Type 2 papillary renal cell carcinoma 0.5740825264042542 1.1466207284554415 0.2515384057069953 1.0 0.8873017157885454 8 P23246,Q09472,Q13617 3 +Familial partial lipodystrophy fpld 0.5931631370585582 1.109989544413445 0.2670035319945578 1.0 0.8873017157885454 6 O75844 1 +Oxidative stress response 0.6126805698853514 1.0853247283960243 0.2777778573309193 1.0 0.8873017157885454 5 P09601 1 +Neuroinflammation 0.8459244532803177 1.0700024790869795 0.2846181928270481 1.0 0.8917027424209114 3 P00403,P42345 2 +Fragile x syndrome 0.4155986081904929 1.0628230159146492 0.2878622198983538 1.0 0.8962878290876383 37 Q9UPY3,P51648,P42345,Q96CW1,Q9Y4R8,Q9NZ01,Q15334,P05067,P53985 9 +Cytoplasmic ribosomal proteins 0.3637798347556498 1.0567037407504802 0.2906468172423411 1.0 0.8962878290876383 71 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P36578,P46781,P47914,P61254,P08708,P46783,Q07020,P83881 38 +Burn wound healing 0.5695223335937255 1.0201897306856582 0.3076384870366886 1.0 0.9105480847467818 7 P09429,P08670,P07737 3 +Rala downstream regulated genes 0.592702923431901 1.000787623370848 0.3169294943741918 1.0 0.9254754936631796 5 P16989,P63000 2 +Sulfation biotransformation reaction 0.8256368812510371 0.9983039595970452 0.3181319881544389 1.0 0.9254754936631796 3 P00390 1 +Wnt signaling pathway and pluripotency 0.4636517783859558 0.994972273705665 0.3197497495290102 1.0 0.9254754936631796 16 P43034,Q13362,Q13363,Q09472 4 +Interferon type i signaling pathways 0.4862930000842029 0.9823092516205872 0.3259475180861741 1.0 0.9288191973213048 12 Q53EL6,P63000,P42345,Q99873 4 +Inclusion body myositis 0.8135144087446222 0.981335909004926 0.3264271202810018 1.0 0.9288191973213048 2 P05067 1 +Cellular proteostasis 0.6358717670945349 0.9038552707383368 0.3660721496633341 1.0 0.9707600186011324 4 Q99471,O15212 2 +Progeriaassociated lipodystrophy 0.4996458481499878 0.9007541265340772 0.3677190629982307 1.0 0.9707600186011324 9 O75844 1 +Degradation pathway of sphingolipids including diseases 0.542593156750534 0.8885110143897199 0.3742659337481198 1.0 0.9707600186011324 6 O43681,P16278,P06280 3 +P53 transcriptional gene network 0.5178549126339582 0.8862483714081933 0.3754837031585694 1.0 0.9707600186011324 8 Q9UPY5,P04066,P30038,P43246,P13010 5 +Pancreatic adenocarcinoma pathway 0.4448072605579092 0.8857021087062156 0.3757780717165673 1.0 0.9707600186011324 16 P11802,Q00534,P42345,P30086 4 +Vitamin d metabolism 0.788270377733626 0.868364793492657 0.38519466189986 1.0 0.971748864865831 3 P04062,P38435 2 +Glioblastoma signaling pathways 0.4303341886301887 0.8592704872830691 0.3901913026725623 1.0 0.971748864865831 18 O00443,Q09472,P11802,Q13315,Q00534 5 +Glutathione metabolism 0.5322408648605287 0.8438084867797992 0.3987764323005569 1.0 0.9732767088916088 6 P00390 1 +Integrated cancer pathway 0.4528522538393379 0.8366074867170649 0.4028132359199714 1.0 0.9732767088916088 13 P11802,O14757,P06493,Q13315,P52701 5 +Head and neck squamous cell carcinoma 0.4842699411407993 0.8271725818545108 0.4081392497593847 1.0 0.9732767088916088 9 P11802,Q00534,P42345 3 +Spinal cord injury 0.4378564693473495 0.8217274254556967 0.4112320466582218 1.0 0.9732767088916088 15 P11802,P06493,P27361,P63000,P08670,Q9NQC3 6 +Selenium micronutrient network 0.4612357588860266 0.8214954879900257 0.4113640931068885 1.0 0.9732767088916088 11 Q8WTV0 1 +Hepatitis c and hepatocellular carcinoma 0.5023566485683305 0.8155487565167998 0.4147582678967569 1.0 0.9732767088916088 8 Q14247,P27361,P55210,P63000 4 +Dna damage response 0.3950650696863953 0.790613471720344 0.4291695830307427 1.0 0.9732767088916088 22 Q86UE8,P11802,O14757,Q13315,Q00534,P15927 6 +Iron metabolism in placenta 0.7618416694269667 0.7882930274949993 0.4305253251446674 1.0 0.9732767088916088 2 P02786 1 +Gdnfret signaling axis 0.6049375179186226 0.7858101683023415 0.4319787085729398 1.0 0.9732767088916088 4 Q12948 1 +Cholesterol biosynthesis pathway 0.4485121123984688 0.7837393529826711 0.4331930662427976 1.0 0.9732767088916088 12 Q15800,Q16850 2 +Initiation of transcription and translation elongation at the hiv1 ltr 0.4732554230082644 0.774937497490319 0.4383765933851449 1.0 0.9732767088916088 9 P18615,Q09472 2 +3q29 copy number variation syndrome 0.4563056665257275 0.7710313191578734 0.4406883679306825 1.0 0.9732767088916088 10 P63167,Q8NCM8,P02786,O94888,P61088,P55210 6 +Hostpathogen interaction of human coronaviruses autophagy 0.7579110969284031 0.7655610750591699 0.443937512829585 1.0 0.9732767088916088 3 Q9NT62 1 +Caloric restriction and aging 0.7575179800561725 0.7642499971564648 0.4447182771066991 1.0 0.9732767088916088 3 P43490 1 +Mirna regulation of dna damage response 0.3840560362843011 0.7634435786920957 0.4451988988059874 1.0 0.9732767088916088 23 Q86UE8,P11802,O14757,Q13315,Q00534,P15927 6 +G1 to s cell cycle control 0.3758768421100331 0.7576139807947293 0.4486821080474719 1.0 0.9732767088916088 24 P49736,P11802,P27694,P49643,P33992,P06493,Q13315,P12004,Q07864,Q00534,O43913,Q14566,P14635,Q9Y619,P35244,P15927 16 +Mirna biogenesis 0.755135851557335 0.7563175076654157 0.4494588536816937 1.0 0.9732767088916088 3 Q9UPY3,P62826 2 +Dna repair pathways full network 0.3572244645399756 0.7344257046826341 0.4626893253755888 1.0 0.985349312001741 49 Q96T60,Q9UQ84,Q9NRF9,P28340,Q9UGN5,O14757,P32780,Q13315,P12004,Q07864,P19447,P40938,P52701,P09429,P29372,Q15554,P15927 17 +Praderwilli and angelman syndrome 0.4983933543117205 0.7002782916886261 0.4837535260265266 1.0 0.9927903373854502 6 P11802,Q00534,Q15154 3 +Proteasome degradation 0.3671216877010904 0.68565259516528 0.492932206720279 1.0 0.9977218892035888 38 P60900,P49720,P49721,P28070 4 +Mitochondrial complex iv assembly 0.4222888156912334 0.6748088431892842 0.4997972212702506 1.0 0.9987606323400904 13 P00403,Q96I36,P14406,Q9Y2R0 4 +Bmp signaling in eyelid development 0.7293805895992114 0.672764278757947 0.5010972666380633 1.0 0.9987606323400904 2 Q12948 1 +Oxysterols derived from cholesterol 0.487581798734727 0.655537725842117 0.5121216052239705 1.0 1.0 6 O00154,Q9Y305 2 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.4144415922370447 0.6340982410277589 0.5260167106339833 1.0 1.0 13 Q13347,O75821,P55010,P20042,P05198,O15372,O00303,O75822 8 +Purine metabolism and related disorders 0.4112338806664605 0.6175815417043901 0.5368512150763514 1.0 1.0 13 Q9BY32,P22102,P30566,P30520,Q06203 5 +15q112 copy number variation syndrome 0.7113982770046361 0.6148862167057237 0.5386298659716622 1.0 1.0 3 Q9BSJ2,Q06787 2 +4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression 0.4903807341982534 0.585462251198648 0.5582369417043049 1.0 1.0 5 P42345,Q96KB5 2 +Tcell antigen receptor tcr pathway during staphylococcus aureus infection 0.4043119157046642 0.5822117694826392 0.560424046669338 1.0 1.0 13 O95433 1 +Atr signaling 0.7008943358728121 0.576365939763165 0.5643678613631113 1.0 1.0 2 O14757 1 +Translation factors 0.3531824696707621 0.5704900433191693 0.568345373313262 1.0 1.0 36 P26641,P49770,Q9NR50,O75153,Q13347,P29692,P55010,P19525,P20042,Q13144,Q15056,O15372,P63241,Q14232,O75821,P05198,Q05639,O00303,O75822,Q14240 20 +Mitochondrial long chain fatty acid betaoxidation 0.3879187841934519 0.5644423476385402 0.5724531256117511 1.0 1.0 16 P23786,P49748 2 +Dna replication 0.3480461833386661 0.5416502052037626 0.5880594989366141 1.0 1.0 28 P49736,P28340,P27694,P49643,Q7L590,P33992,P12004,Q07864,Q9Y619,O43913,P40938,Q14566,P09884,P35244,P15927 15 +Target of rapamycin tor signaling 0.4577202125604248 0.5357670697741003 0.5921195436301459 1.0 1.0 6 P54646,P42345 2 +Insulin signaling in adipocytes diabetic condition 0.684666101032761 0.5331956029147672 0.5938981850036755 1.0 1.0 3 P42345 1 +Insulin signaling in adipocytes normal condition 0.684666101032761 0.5331956029147672 0.5938981850036755 1.0 1.0 3 P42345 1 +Ovarian infertility 0.6765088375499848 0.5091272023896464 0.6106630656570462 1.0 1.0 3 P11802 1 +Electron transport chain oxphos system in mitochondria 0.3288328549434077 0.5015822398501162 0.6159614149154322 1.0 1.0 50 O14949,Q9Y6M9,P14406,P03886,P00403,P00846,O75964,Q9UDW1 8 +Aryl hydrocarbon receptor pathway wp2586 0.4301720047375365 0.5012504578428405 0.6161948671784434 1.0 1.0 8 Q09472,O00170 2 +Mitochondrial complex ii assembly 0.6747267307055391 0.4928793998873423 0.6220978037568838 1.0 1.0 2 P21912 1 +Nonsmall cell lung cancer 0.3940971424590145 0.4914928772518374 0.6230778886364576 1.0 1.0 11 P11802 1 +Allograft rejection 0.4246376216092433 0.4786972353217471 0.6321540329068782 1.0 1.0 8 P08183,P08670,P55210 3 +Glial cell differentiation 0.6598211328254469 0.4478364153829234 0.6542712602323781 1.0 1.0 2 P09543 1 +Fatty acid betaoxidation 0.3432010269949507 0.4260761034878344 0.6700523923043333 1.0 1.0 21 P23786,P49748 2 +Mitochondrial immune response to sarscov2 0.3910528725122499 0.408723705300248 0.6827424352755711 1.0 1.0 9 Q9Y6M9,Q9H845 2 +Supression of hmgb1 mediated inflammation by thbd 0.6401171716410023 0.4074173615923366 0.6837014776492771 1.0 1.0 3 P09429 1 +Mitochondrial complex i assembly model oxphos system 0.3234695582048464 0.3881122052964528 0.6979330000255788 1.0 1.0 26 P03886,Q96CU9 2 +Familial hyperlipidemia type 4 0.6266975819807978 0.3552190611320994 0.7224254859664028 1.0 1.0 2 Q9UBV2 1 +Synaptic signaling pathways associated with autism spectrum disorder 0.4067277674752953 0.3492482230761261 0.7269029658954691 1.0 1.0 6 Q15334,P54646,P42345 3 +Hematopoietic stem cell gene regulation by gabp alphabeta complex 0.403159936879606 0.3372902150995768 0.7358981352105252 1.0 1.0 6 Q13315,Q15554,Q09472 3 +Erk pathway in huntingtons disease 0.6123556428388214 0.3369082529624779 0.7361860637093454 1.0 1.0 3 P42858 1 +Melanoma 0.3723611283671784 0.3348101682687199 0.7377682896169966 1.0 1.0 9 P11802,P63000,Q00534 3 +Splicing factor nova regulated synaptic proteins 0.3408076273514102 0.3329900092210144 0.7391418247098742 1.0 1.0 17 Q7Z460,Q9BY67 2 +Parkinsons disease pathway 0.3940298507462617 0.3074533619841393 0.7584983166730483 1.0 1.0 6 P68036,P07814,Q99497,Q99700,P55210 5 +Sterol regulatory elementbinding proteins srebp signaling 0.3050731629370701 0.2810378755992553 0.7786813494996949 1.0 1.0 25 Q15436,Q14534,P42345,Q16850,Q8WTV0 5 +Pparalpha pathway 0.370766415185518 0.2774785316517867 0.7814126881359427 1.0 1.0 8 P23786 1 +Mesodermal commitment pathway 0.312473502144367 0.2764859151151922 0.7821748762974439 1.0 1.0 22 Q8IWS0,Q9H6R7,P42858,Q16527 4 +Triacylglyceride synthesis 0.5842221452988459 0.2726105810810413 0.7851525773977412 1.0 1.0 3 Q99943 1 +Nucleotide excision repair 0.3029257872563987 0.2483487262685713 0.8038646014804991 1.0 1.0 23 Q9NRF9,P28340,P12004,P19447,P40938,P32780,P15927 7 +Energy metabolism 0.3379729952870025 0.2448888890011427 0.8065424650905966 1.0 1.0 10 Q15648,Q99873 2 +Regulation of actin cytoskeleton 0.3032848716770604 0.2387246563053939 0.811319096473982 1.0 1.0 30 O00443,Q9UQB8 2 +Sarscov2 innate immunity evasion and cellspecific immune response 0.3353572338701652 0.2354031132871512 0.8138958699104384 1.0 1.0 10 Q09472 1 +Homologous recombination 0.3705138614394191 0.2345643984252775 0.8145468445796495 1.0 1.0 7 P28340 1 +Network map of sarscov2 signaling pathway 0.3004232328642123 0.2345002902398945 0.8145966078908573 1.0 1.0 23 Q96J02,P42345,Q9UGN5,P14635,P06493,P63000,Q08380,Q96AX1,Q14240,Q99829 10 +Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells 0.3517616166973444 0.1819926010600402 0.8555885324362569 1.0 1.0 7 P31943,Q8WUM4 2 +Microtubule cytoskeleton regulation 0.3038003135276784 0.153709519583987 0.8778387784478292 1.0 1.0 15 Q7Z460,P63000,P46821,P06493 4 +Leukocyteintrinsic hippo pathway functions 0.3396938537326627 0.1513246667444297 0.879719612087621 1.0 1.0 7 Q96GC9 1 +Dual hijack model of vif in hiv infection 0.5250082808877246 0.1481450129628434 0.8822283261385708 1.0 1.0 2 Q93034 1 +Vasopressinregulated water reabsorption 0.3037893098552511 0.1459170268885357 0.8839868899440682 1.0 1.0 14 P63167,Q8NCM8,Q9UJW0,P52565 4 +Aspirin and mirnas 0.5157336866512228 0.1355073980129124 0.8922107154400416 1.0 1.0 2 Q15118 1 +Prion disease pathway 0.3216504394700331 0.1326371106051062 0.8944803816858731 1.0 1.0 8 P49711 1 +Pilocytic astrocytoma 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 +Transsulfuration pathway 0.3198960997026386 0.1282908315995554 0.8979188204743136 1.0 1.0 8 P26358,P48507,P32929 3 +Effect of progerin on genes involved in hutchinsongilford progeria syndrome 0.2991026919242325 0.1208999978567147 0.9037702438690958 1.0 1.0 12 Q13330,P04637,Q92769,P83916,Q13547,O95983,P45973,O60341,Q9BTC8,O94776,Q13185 11 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.296246377292865 0.1148288542744881 0.9085807779227408 1.0 1.0 13 P16989,P05067,P55210 3 +Nonalcoholic fatty liver disease 0.2819308193621122 0.0960948485596306 0.9234452426283326 1.0 1.0 45 Q96GC9,Q9Y6M9,Q86Y39,P14406,P00403,O14949,Q9UDW1 7 +Glycerophospholipid biosynthetic pathway 0.314221364721537 0.0951977074780051 0.9241577908862088 1.0 1.0 7 P48651,Q8WUK0 2 +Pi3kakt signaling pathway 0.2818166601799782 0.0949380250280488 0.924364053304483 1.0 1.0 35 Q13362 1 +Wnt signaling pathway 0.2944307518189061 0.0904093306765019 0.927961942252749 1.0 1.0 9 Q00534,Q13363,P42345 3 +Pentose phosphate pathway in senescent cells 0.3047082228116719 0.0772983189776838 0.9383862281693808 1.0 1.0 5 P29401,P11413,P04637,O95336 4 +Pentose phosphate metabolism 0.3047082228116716 0.0772983189776838 0.9383862281693808 1.0 1.0 5 P52209,P11413,P29401,O95336 4 +Disruption of postsynaptic signaling by cnv 0.3020499336695209 0.0726007679739333 0.9421238155800484 1.0 1.0 7 P27361,Q14168,Q06787 3 +Pi3kaktmtor vitd3 signaling 0.3330500493765924 0.0716669230075827 0.9428669800659026 1.0 1.0 4 P42345 1 +Ebsteinbarr virus lmp1 signaling 0.3189747124073036 0.0590627710678458 0.9529021112356126 1.0 1.0 4 O15111 1 +Hostpathogen interaction of human coronaviruses interferon induction 0.289456233421749 0.0586506901218018 0.9532303352624756 1.0 1.0 5 O14920,P19525,O15111,Q7Z434 4 +Focal adhesion pi3kaktmtorsignaling pathway 0.2735851977401172 0.0548868565154094 0.9562286030757394 1.0 1.0 34 Q13362 1 +Type ii diabetes mellitus 0.3092451366944628 0.0516750211059089 0.9587876409101904 1.0 1.0 4 P42345 1 +Unfolded protein response 0.3946322067594367 0.0473091892706361 0.9622668043059768 1.0 1.0 3 P05198,Q9Y3I0 2 +Hedgehog signaling pathway wp4249 0.3943008614976742 0.0471872131881178 0.9623640185681674 1.0 1.0 3 P48729,Q13618 2 +Notch1 regulation of endothelial cell calcification 0.382245776747277 0.0470660883574024 0.9624605549410844 1.0 1.0 2 O43852 1 +Methionine metabolism leading to sulfur amino acids and related disorders 0.2775198938992099 0.046487548143939 0.9629216584991372 1.0 1.0 5 P23526,P55263,P32929,Q99707 4 +Tnfrelated weak inducer of apoptosis tweak signaling pathway 0.2736549051873208 0.0359659400559393 0.9713095172713736 1.0 1.0 8 P63000,O15111,P55210 3 +Mrna protein and metabolite inducation pathway by cyclosporin a 0.3409542743538704 0.0343883573081172 0.972567467504252 1.0 1.0 3 P08195,Q9UPY5 2 +Proximal tubule transport 0.2614206018461052 0.0289569572094468 0.9768989193565588 1.0 1.0 10 P08183 1 +Notch signaling pathway 0.2610899292032211 0.028322939664324 0.9774045847309284 1.0 1.0 10 Q96J02,Q09472 2 +Neural crest cell migration during development 0.2306927411335728 0.0218375515456872 0.9825775395202244 1.0 1.0 4 Q99570,P63000,Q13177 3 +Mammary gland development pathway pregnancy and lactation stage 3 of 4 0.2167716274444761 0.0201805608390875 0.9838993349317208 1.0 1.0 4 O15111,P06753,P61201 3 +Osteopontin signaling 0.236737400530505 0.0188419232167536 0.98496720986014 1.0 1.0 5 O14920,P27361,O15111,Q02750 4 +Tumor suppressor activity of smarcb1 0.2558447233474203 0.0088554520341259 0.9929344638885768 1.0 1.0 12 P11802,Q00534 2 +Ncrnas involved in wnt signaling in hepatocellular carcinoma 0.2474225467372952 0.0042870096839452 0.996579471638507 1.0 1.0 9 Q13363,Q86UE4 2 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e2993a765c570208ce5998645428620f2f69a1a9 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amplification and expansion of oncogenic pathways as metastatic traits", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Arylamine metabolism", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between loxl4 and oxidative stress pathway", "Interactions of natural killer cells in pancreatic cancer", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Ldlrad4 and what we know about it", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABI1", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSF2", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "APEX1", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG9A", "ATIC", "ATM", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "B4GALT1", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAT2", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BLVRA", "BPTF", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "C1QBP", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZB", "CARM1", "CASK", "CASP7", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC6", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHKA", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHUK", "CIP2A", "CKB", "CLASP1", "CLIC1", "CLK2", "CLK3", "CLPTM1L", "CLTC", "CLUH", "CMPK1", "CNOT1", "CNOT9", "CNP", "COA3", "COASY", "COL4A3BP", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COQ8A", "COQ9", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPT1A", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DARS", "DAXX", "DBNL", "DCAF1", "DCAF7", "DCP1A", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHTKD1", "DHX15", "DHX16", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJB11", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "EP300", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPRS", "ERBIN", "ERCC2", "ERCC3", "ERI1", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC2", "EXOSC4", "EXOSC7", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAH", "FAM120A", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP15", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GID8", "GIGYF2", "GLA", "GLB1", "GLRX", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTPBP4", "GUSB", "GYG1", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIRA", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMGN5", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF2", "ILK", "IMP3", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIDINS220", "KIF15", "KIF20B", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC1", "KMT2A", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LGALS3BP", "LIG1", "LIG3", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP2", "LPGAT1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM2", "LSS", "LTA4H", "LUC7L", "LYN", "LZTFL1", "MACF1", "MAD2L1", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MEPCE", "MFGE8", "MFN2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MMACHC", "MOGS", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPG", "MPI", "MPP1", "MPP2", "MPP5", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MUT", "MVK", "MYBBP1A", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEO1", "NFATC2IP", "NIPBL", "NKRF", "NME1", "NME2", "NME6", "NONO", "NOP2", "NPC1", "NRP1", "NSD1", "NSDHL", "NSF", "NT5C3A", "NTHL1", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "ORC3", "ORC5", "OTUD7B", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PATJ", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KA", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN2", "PKP2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNKP", "PNP", "PNPLA8", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PVR", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB21", "RAB23", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBFOX2", "RBM14", "RBM17", "RBM39", "RBM4", "RBM47", "RBMX", "RBPMS", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTKN", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAF11", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDF2L1", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SNAP23", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRC", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STIP1", "STK4", "STMN1", "STRAP", "STUB1", "STX3", "STXBP2", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TACO1", "TAF6", "TALDO1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCF20", "TCP1", "TECR", "TELO2", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIMELESS", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMED10", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPMT", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP13", "TRMT2A", "TRRAP", "TSG101", "TTC19", "TTC26", "TTF2", "TTI1", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWISTNB", "TXN2", "TXNDC5", "TXNL4A", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR2", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VASP", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS33A", "VPS36", "VPS37B", "VPS37C", "WAPL", "WARS", "WDCP", "WDHD1", "WDR1", "WDR5", "WFS1", "WIPI2", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM3", "ZNF281", "ZYX"], "leading_proteins": ["AAMP", "ABCB1", "ACAD9", "ACADVL", "ACAT2", "ACOT7", "ACOT9", "ADK", "ADSL", "ADSS", "AGPAT1", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "ALDH3A2", "ALDH4A1", "AP2M1", "APP", "ARHGDIA", "ASAH1", "ASNA1", "ATG3", "ATG9A", "ATM", "ATP5L", "ATP6", "ATXN2", "BAIAP2", "BCAT2", "CADM1", "CALU", "CARM1", "CASP7", "CBX1", "CBX3", "CBX5", "CCNB1", "CDK1", "CDK4", "CDK6", "CERS2", "CHEK1", "CHKA", "CHST14", "CHUK", "CLASP1", "CLPTM1L", "CLUH", "CNP", "COA3", "COL4A3BP", "COPS2", "COX14", "COX2", "COX7A2", "CPNE1", "CPT2", "CSNK1A1", "CSRP2", "CTBP1", "CTBP2", "CTCF", "CTH", "CTTN", "CUL2", "CUL3", "CUL5", "CYB5B", "CYP51A1", "DCTN4", "DDX20", "DHCR24", "DHFR", "DICER1", "DNMT1", "DYNC2H1", "DYNLL1", "DYNLL2", "ECE1", "EEF1A2", "EEF1D", "EEF1G", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A2", "EIF4H", "EIF5", "EIF5A", "EP300", "EPHX1", "EPRS", "ERCC3", "EXO1", "FMR1", "FOXC1", "FOXRED1", "FUCA1", "G6PD", "GART", "GBA", "GCLM", "GGCX", "GLA", "GLB1", "GRB2", "GSR", "GSTO1", "GTF2H1", "GUSB", "HDAC1", "HDAC2", "HLTF", "HMGB1", "HMGB2", "HMOX1", "HNRNPH1", "HS2ST1", "HSP90AA1", "HTT", "ICMT", "IFT27", "IKBKB", "ITCH", "ITPA", "KDM1A", "KDM1B", "KIF5B", "LBR", "LGALS3BP", "LLGL1", "MAP1B", "MAP2K1", "MAPK3", "MAVS", "MBD3", "MCM10", "MCM2", "MCM5", "MCM6", "MED1", "MPG", "MPP2", "MSH2", "MSH6", "MSMO1", "MTA1", "MTA2", "MTA3", "MTDH", "MTOR", "MTR", "NAGLU", "NAMPT", "ND1", "NDUFA11", "NDUFB9", "NELFE", "NPC1", "ORC5", "PAFAH1B1", "PAK2", "PARK7", "PARP2", "PBK", "PCM1", "PCNA", "PDCD4", "PDCD6IP", "PDK1", "PEBP1", "PFDN5", "PFDN6", "PFN1", "PGD", "PGLS", "PHF6", "PIK3C2A", "PIK3R4", "PIP4K2C", "PNKP", "POLA1", "POLD1", "POLE", "POLE3", "PON2", "POR", "PPAT", "PPP2R5C", "PRIM2", "PRKAA2", "PRMT1", "PRMT3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PTDSS1", "PTGES3", "PTPMT1", "RAC1", "RAN", "RBPMS", "RFC3", "RPA1", "RPA2", "RPA3", "RPL10", "RPL12", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL24", "RPL26", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL35A", "RPL36", "RPL36A", "RPL37A", "RPL4", "RPL6", "RPL8", "RPL9", "RPS10", "RPS11", "RPS15", "RPS15A", "RPS17", "RPS2", "RPS23", "RPS3", "RPS4X", "RPS5", "RPS8", "RPS9", "RTCB", "RTN3", "RTN4", "SCARB1", "SCARB2", "SDHB", "SEC23A", "SEL1L", "SFPQ", "SGPL1", "SLC16A1", "SLC25A15", "SLC25A20", "SLC35B2", "SLC3A2", "SLC7A11", "SQLE", "TECR", "TELO2", "TERF2", "TFRC", "TKT", "TLK2", "TP53", "TPM3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "UBA3", "UBE2L3", "UBE2N", "UBXN7", "UGCG", "UGT8", "UQCR10", "UQCRQ", "VDAC1", "VDAC2", "VIM", "VMP1", "VPS33A", "WDCP", "WIPI2", "XRCC5", "YBX3", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/opencell_localization/basic/idx2term.json b/opencell_localization/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..64662c55627122664d730062a093a31f6df8205a --- /dev/null +++ b/opencell_localization/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "cytoskeleton", "1": "golgi", "2": "membrane", "3": "big_aggregates", "4": "er", "5": "centrosome"} \ No newline at end of file diff --git a/opencell_localization/basic/plot_0.png b/opencell_localization/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..b384ca5d44a0b5f70fe78ba8a9eef5948cfb2329 --- /dev/null +++ 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b/opencell_localization/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +mitochondria 1 11 2.6763697187651845 0.0074424494567637 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0013157873870524 0.0016377422378922 0.0066572828402184 0.0385233102424958 0.1302253804689002 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d1c03f30a8d22ff576e78d06dcb8ea19f3be2130 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 89.58823529411765 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..611e2ca6fa541a71afe02156edb089411536f2ac --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..baabccbe954fab5a344946f440cff15966b91191 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +mitochondria 0.8348556881046008 2.6763697187651845 0.0074424494567637 0.1192617522914354 0.1265216407649838 11 P21796 1 +cytoskeleton 0.4430784289355954 1.2434469031749982 0.2137031955960044 0.9832130931308604 0.7268966347386122 32 P63167,P35580,P68371,Q7Z460,Q13042,P06493,Q9UHD8,Q15019,P08670,P14635,P60660,Q9NVA2,Q96FJ2 13 +golgi 0.3975143380758523 1.24320275471597 0.2137931278642977 0.983245703169027 0.7268966347386122 54 P40616,Q5VW38,Q8IXU6,Q15436,P22059,P62820,O43826,Q9Y5P4,O15258,Q9Y487,O14579,P35606,Q9NR31,Q8IZA0,Q7Z3C6 15 +membrane 0.2858803411845917 0.2193583940078073 0.8263708775073226 0.9999999999998817 1.0 74 Q8NC96,P04920,P02786,Q9Y5X1,P22059,Q9NVZ3,P63000,Q68EM7,Q15286,Q9UQB8,O15145,Q9NQC3,P53985,P08670,Q8TBX8,Q9NVA2 16 +big_aggregates 0.2900764120834506 0.1733017793834269 0.862414225109859 0.9999999999999978 1.0 28 P55210,P26196,Q9Y5X1,P14550,Q8IV63,Q9NT62,Q96EK5,P62826 8 +er 0.2828166130450212 0.1542143380310842 0.8774407373132473 0.9999999999999996 1.0 78 Q8N4V1,Q96N66,Q14739,Q96GC9,Q969V3,O95470,Q16850,Q8TBX8,Q9NQC3,Q15392,Q8WUX9,Q9Y487,O15173 13 +centrosome 0.2804682465494937 0.1431776535931783 0.886149877825624 1.0 1.0 25 P33176,Q10713,Q7Z460,Q04917,P06493,P53350,Q9Y6G9,Q96FJ2 8 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f2161e9baf9b55eb3ab9ab71b70284cfffe10990 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AGAP3", "AHCY", "AHSA1", "AKAP12", "AKAP8L", "AKR1A1", "ALCAM", "ALDH9A1", "ALG2", "ANAPC2", "ANAPC4", "ANXA11", "AP2B1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARPC2", "ARPC3", "ATG3", "ATG4B", "ATG9A", "ATL2", "ATM", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BMS1", "BOP1", "BPNT1", "BRD2", "BRD4", "BTF3", "BUB1B", "BYSL", "C12orf57", "C1orf123", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CASP7", "CBX1", "CCAR1", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CETN2", "CHEK1", "CHEK2", "CHMP1A", "CHMP2A", "CHMP7", "CHUK", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLINT1", "CLK2", "CLK3", "CLPTM1", "CLTC", "COIL", "COL4A3BP", "COMMD2", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DBNL", "DCP1A", "DCP2", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1LI1", "DYNLL1", "DYNLL2", "EBNA1BP2", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC3", "EMC4", "EMC7", "EMG1", "ENO1", "ERG28", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FAM50A", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GNL2", "GNL3", "GOLGA2", "GOLT1B", "GOSR1", "GPAT4", "GPR107", "GRB2", "GSPT1", "GTPBP4", "GYG1", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HIP1", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HMGN5", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSF1", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPBP1", "HSPH1", "IDI1", "IGF1R", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF3", "ILK", "IMP3", "INTS14", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LAMTOR2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD3", "LIG1", "LMAN1", "LMNA", "LMNB1", "LNPK", "LPCAT1", "LSM14B", "LSS", "MAP2K1", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MARK2", "MBOAT7", "MCM10", "MDH1", "MECP2", "MED17", "MED21", "MED24", "MED4", "METAP2", "MFN1", "MFN2", "MIF", "MKI67", "MMGT1", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTOR", "MVK", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1E", "MYO6", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NDRG1", "NECAP1", "NECAP2", "NEK9", "NEMF", "NHP2", "NIFK", "NMD3", "NOL10", "NOL11", "NOM1", "NONO", "NOP10", "NOP2", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP98", "NUTF2", "NVL", "NXF1", "OCRL", "OSBP", "OSBPL11", "OSBPL8", "OXSR1", "PABPC4", "PACSIN2", "PACSIN3", "PAIP1", "PAK2", "PARP1", "PBK", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PFDN6", "PFN1", "PGK1", "PGRMC1", "PGRMC2", "PHAX", "PHF10", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIN4", "PIP4K2C", "PKM", "PKMYT1", "PKN2", "PLK1", "PMPCA", "PMVK", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "PPM1G", "PRKACA", "PRKDC", "PRMT9", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTDSS1", "PTGES3", "PTK7", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB35", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB7A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAN", "RANBP1", "RANBP2", "RANBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM7", "RBMX", "REEP4", "REEP5", "REEP6", "RER1", "RHOA", "RNASEH2A", "RNF40", "ROCK1", "RPL10A", "RPL11", "RPL13", "RPL19", "RPL27", "RPL35", "RPL4", "RPL5", "RPN1", "RPN2", "RPP30", "RPS11", "RPS14", "RPS16", "RPS18", "RPS6KA1", "RPS6KA3", "RRP1", "RRP36", "RSL1D1", "RTCB", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "SACM1L", "SAE1", "SAR1A", "SARS", "SBDS", "SCFD1", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24C", "SEC31A", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A17", "SLC27A4", "SLC35F2", "SLC37A4", "SLC4A2", "SLK", "SMARCA1", 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b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:acf55d54c9ec2e24bd9ff724679073cb92af2a4640fa707cc0dbe043f5a99ff4 +size 76698 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..87b100f7bdfc3a7a97ed26de08fc9fc05d7e3090 --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,11 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +serine protease 5 19 2.992789167418836 0.0027644064627925 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 0.00112460538858 0.001549818040453 0.0012207780133745 0.0011347755104788 0.000525961744528 +membrane trafficking regulatory protein 7 21 2.8627822688369973 0.0041993902641064 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 0.0014132660261148 0.0019447965050573 0.0142561824639166 0.0002745543568096 0.0038997222190096 +tubulin 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +hydrolase 8 20 2.718315182685354 0.0065615301295589 5.730582524271845 22.686893203883496 0.1039794126037792 0.5340059271703876 3.435640815918521 2.8019623945440895 0.9464611702434822 0.3066554522137604 1.0 1.0 0.0017566671607845 4.326822479953282e-05 0.0010962746178068 +acyltransferase 3 15 2.370128319468156 0.0177819126023648 5.550970873786408 17.609223300970875 0.8395368249042097 0.3495065414698917 3.0409541216574527 2.8086572783837886 1.152491475155923 0.3107783941454108 0.0134432571670497 0.0165768393094286 0.0075361578498098 0.0185450998789275 0.0524034739320251 +oxygenase 3 8 2.2590839394931934 0.023878163977459 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.004520933605864 0.0056070915236824 0.0219975904219434 0.0024740226177806 0.0274602362801676 +oxidase 4 14 2.2562375622548267 0.0240557573152901 5.111650485436893 13.890776699029129 1.1786899361665428 0.2351652471103072 2.6295852591466065 1.831549924215542 1.2715889014379809 0.2754701040210626 1.0 1.0 0.2732850813359189 0.0080316637526189 0.0208457080812305 +transporter 12 54 2.1648804602683898 0.0303968409510884 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 0.0869984012179004 0.1048052867755766 0.0260774389953396 0.0239312888847215 0.0016472332548941 +primary active transporter 6 23 2.139090994083497 0.0324282996429658 8.614077669902912 23.45631067961165 1.2392440710771837 0.271771563990288 4.792195908457348 3.1431129799052804 1.4794913205770832 0.3014776193450941 0.2311171554709545 0.2543128795765555 0.1194965359594502 0.0171674062949385 0.030712608331405 +kinase 5 19 2.01281834341724 0.0441337434293376 5.342233009708738 19.16990291262136 0.4829035688938301 0.5416328570606787 2.5230708027725983 3.055357699220451 0.834324426685503 0.3184920920789588 0.2376285909357172 0.2613604367755145 0.4620800234731917 0.019457743384681 0.0913317871121833 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..17e87f313cd523d33f206cb310a5944e11c2ac0c --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 154, + "title": "Average number of proteins per term", + "value": 13.584415584415584 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d1433f1c8813d18d83d0db8cc36a71331f112c77 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e5dd5c8f96db8ba1b692161c6c609b35a09835b1 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,52 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +serine protease 0.7893386081379731 2.992789167418836 0.0027644064627925 0.3470848595898952 0.2526189099880198 19 P67812,Q9HB40,P42785,O14773,P10619 5 +membrane trafficking regulatory protein 0.7348591582243903 2.8627822688369973 0.0041993902641064 0.476944551188611 0.2526189099880198 21 P24390,O43760,Q14108,P50542,Q8WTV0,Q96AX1,O00560 7 +tubulin 0.972130059721299 2.730276917747799 0.0063281145339988 0.6237969204573557 0.2526189099880198 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +hydrolase 0.7238680130153461 2.718315182685354 0.0065615301295589 0.6371643661000956 0.2526189099880198 20 Q96AB3,Q9Y3Z3,O60502,P07099,Q86WA6,O43598,P15586,O43865 8 +acyltransferase 0.7188758144043634 2.3701283194681557 0.0177819126023648 0.9369012421607862 0.2964463587250076 15 Q9BWD1,P23786,Q8NCC3 3 +oxygenase 0.8203755754026503 2.2590839394931934 0.023878163977459 0.9758108653710864 0.2964463587250076 8 P30519,P09601,Q16850 3 +oxidase 0.7092148941962753 2.2562375622548267 0.0240557573152901 0.9764792596752132 0.2964463587250076 14 Q15800,Q8NB78,O75880,P14406 4 +transporter 0.4951349265867677 2.1648804602683898 0.0303968409510884 0.9913805539431584 0.2964463587250076 54 O60830,Q99808,Q99595,Q9H2D1,Q9NR77,Q567V2,P55060,Q9HD45,P53985,O43681,O43772,Q99805 12 +primary active transporter 0.5861695526272688 2.1390909940834972 0.0324282996429658 0.9937596885182988 0.2964463587250076 23 Q9GZP9,O60888,O43826,Q8N4H5,Q96NB2,Q9NS69 6 +kinase 0.6128726172649905 2.0128183434172393 0.0441337434293376 0.9990424573589188 0.3089362040053633 19 O00443,P35790,Q8TBX8,Q9BRR6,O00764 5 +calmodulin-related 0.6724723652070458 1.955827907370058 0.0504854301832133 0.9996570336548828 0.3239481770089525 12 Q02818,P80303 2 +mitochondrial carrier protein 0.732908598137765 1.7438183270287264 0.0811907736937027 0.9999978287815384 0.4260206825083193 7 Q9BSK2,Q9NZJ7,Q70HW3 3 +phospholipase 0.725382708083175 1.7110809143777772 0.0870661768860894 0.999999191552522 0.4325222980792829 7 Q8IV08 1 +transmembrane signal receptor 0.6523430629636658 1.63928954043443 0.1011529733368814 0.9999999262756308 0.4604193878363344 9 O15173,Q99720 2 +secondary carrier transporter 0.5853085695490226 1.6026705881673715 0.109007400310106 0.9999999809185696 0.4662351277013622 14 Q96ES6,Q9UBX3,Q9Y6M7,Q8TB61,Q9BQT8 5 +metalloprotease 0.4918624264551564 1.5891898793769532 0.1120175306814961 0.999999988668788 0.4662351277013622 28 Q9NZ08,Q9UIQ6,P42892,Q5JRX3,P52888,O75844 6 +amino acid transporter 0.7993009666762766 1.548838983386559 0.1214204317183345 0.9999999978006756 0.476438461139424 4 O75915,O14925 2 +voltage-gated ion channel 0.9603715355755242 1.481512248759888 0.138470123363636 0.9999999998924444 0.4910698618505618 3 P21796 1 +G-protein coupled receptor 0.9307717787346826 1.440643679448076 0.1496853737090848 0.9999999999857024 0.5027871771194963 2 Q5VW38 1 +esterase 0.6117201962416675 1.3218288484732788 0.1862251496509257 0.9999999999999836 0.5310865378933808 8 Q9NUJ1,O00154 2 +cysteine protease 0.4236878311264048 1.0374842058933138 0.2995102527012916 1.0 0.7439448212257888 23 Q96FW1,Q86UV5,Q96K76,P51784,Q93009,O94966,Q9Y4E8,Q13510 8 +translation factor 0.535629580532613 0.9680741920783544 0.3330073178563277 1.0 0.7889711838442227 8 Q53EL6 1 +protein modifying enzyme 0.4000674369501778 0.9178232628680631 0.3587114012586874 1.0 0.8123758204976156 27 P50897,Q99873,Q6PK18,Q86YN1,Q86X55,O60725,Q15102,Q92791,O75718,O60678 10 +lyase 0.4668567010278772 0.8796685548201159 0.3790388888536822 1.0 0.8459708533835806 12 Q9UHG3,P22830 2 +protease 0.3748707698494289 0.7407106098026458 0.4588689249168842 1.0 0.9383366107939244 37 P60900,P28070,P49720,O43242,P28074,P25788,P20618,Q9UQ80,P49721,P55210 10 +ATP-binding cassette (ABC) transporter 0.4811095910841949 0.7200051170268883 0.4715218449979512 1.0 0.9383366107939244 8 P08183 1 +oxidoreductase 0.365816997194128 0.7068441198600356 0.4796633532844137 1.0 0.9383366107939244 42 Q9Y6M9,Q86Y39,P16435,P00403,Q8N4Q0,O14949,Q6DKJ4,O43169 8 +aspartic protease 0.7300430606161035 0.6750660850548126 0.4996337797733883 1.0 0.9383366107939244 2 Q8TCT9 1 +protease inhibitor 0.4778870303939112 0.6242568236761025 0.532458934273865 1.0 0.9534729753276188 7 P30086 1 +deaminase 0.7028817489234911 0.5829167176038128 0.5599493660023795 1.0 0.958135581826294 2 P52758 1 +ATP synthase 0.3641708834966142 0.552641790236456 0.5805087199723586 1.0 0.9740195394296106 21 Q93050,P21281,Q9Y487,P00846,O75964 5 +translational protein 0.6608148393507864 0.4507780311622947 0.6521495364050862 1.0 1.0 2 Q12904 1 +dehydrogenase 0.3037733691827248 0.4227750859408328 0.672459366650922 1.0 1.0 71 P03886,Q9NZ01,P49748,Q96LJ7,Q96CU9 5 +C2H2 zinc finger transcription factor 0.4439602460904045 0.4173944587653521 0.6763899073099888 1.0 1.0 5 P49711 1 +translation initiation factor 0.323294488432915 0.4026122353904737 0.6872335072251285 1.0 1.0 46 Q9NR50,O75153,Q9Y3F4,P41214,Q9ULC4,O00487,P55010,O75821,Q92905,P46199,Q13144,P63241,P49770,Q9Y262 14 +homeodomain transcription factor 0.6315440689198109 0.3849410301843258 0.7002811061408951 1.0 1.0 3 Q9BTC8,Q13330 2 +carbohydrate kinase 0.4122719734659948 0.3681489841890994 0.7127621476631152 1.0 1.0 6 P51570,P08237,Q03426,P17858,Q01813 5 +ion channel 0.4558992221530795 0.2936682127681106 0.7690114463371556 1.0 1.0 4 Q9C0H2 1 +non-motor microtubule binding protein 0.3262766501869422 0.2532848861397668 0.8000480745226031 1.0 1.0 16 P78559,Q7Z460,O94901,P46821 4 +transfer/carrier protein 0.3493246870782995 0.2508352125535174 0.8019415160071319 1.0 1.0 9 P17900,Q9Y5P4,P12236 3 +membrane traffic protein 0.2865112900862876 0.2405688258344354 0.8098893140381365 1.0 1.0 56 P43307,P20645,Q9BXS5,Q9Y296,A6NIH7,Q8WUX9,P49257,Q9H4M9 8 +histone modifying enzyme 0.3154504867405048 0.205625856068743 0.8370831788778759 1.0 1.0 16 Q9H7B4,O14929 2 +transcription cofactor 0.3188665211306172 0.1787275643835215 0.8581516244147998 1.0 1.0 10 O00625,Q13363,Q7Z4V5 3 +ubiquitin-protein ligase 0.2841226387967404 0.1744005005998955 0.8615507209274074 1.0 1.0 53 Q96J02,O94822,P30260,Q8TBC4,Q13042,P14373,P19474,Q9NT62,P61088,Q15386,O75155,Q9Y263,Q9UBE0,Q13617 14 +transferase 0.2742192637246281 0.0668091539943811 0.9467336358600028 1.0 1.0 32 P48651,P43490,Q9Y5P6,Q9NRN7,Q8NCH0,Q2TAA5,Q7LGA3 7 +cytoskeletal protein 0.2952589262982491 0.065323056751693 0.947916784914356 1.0 1.0 5 Q9NVA2,Q15019 2 +G-protein modulator 0.3168710639708279 0.057376849216161 0.9542450042643228 1.0 1.0 4 P50395,P52565,Q9H2M9 3 +primase 0.3925140775091189 0.0493431715515458 0.9606458154763996 1.0 1.0 2 P49643 1 +phosphodiesterase 0.2670642809807759 0.029618202353765 0.9763715483026264 1.0 1.0 3 Q9NXE4,P09543 2 +actin or actin-binding cytoskeletal protein 0.2633490835136718 0.026479721847244 0.9788747075494196 1.0 1.0 20 P60660,Q16527,O15145 3 +transaminase 0.2608177848708937 0.0231273365078598 0.9815487001350334 1.0 1.0 11 O15269,Q6YP21,O15382,Q8TD30 4 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e62dcdf2a324be62da8f4965b2ebdb1f7cab123f --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deacetylase", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "ANAPC1", "ANAPC7", "ANKFY1", "ANKHD1", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APP", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP5", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD2B", "ATG3", "ATG4B", "ATL2", "ATM", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BAG6", "BAIAP2", "BAP18", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDK", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPHL", "BPNT1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCDC12", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC6", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKN2AIP", "CEBPZ", "CENPB", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLK2", "CLK3", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNP", "COA3", "COASY", "COIL", "COL4A3BP", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWC27", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAKD", "DCP1A", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMG1", "ENAH", "ENO1", "EP300", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "FAHD1", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GID8", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATIP2", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ISOC2", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KMT2A", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDHA", "LDHB", "LENG8", "LEO1", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRIG2", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LSM14B", "LSM2", "LSM6", "LSS", "LTN1", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFSD3", "MFSD5", "MGEA5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTCH2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCEH1", "NCKIPSD", "NCOA5", "ND1", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NENF", "NFS1", "NGDN", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OTUD7B", "OXCT1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARL", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF10", "PHF14", "PHF3", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBFOX2", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBM47", "RBM7", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIDA", "RIF1", "RNASEH2A", "RNMT", "ROCK1", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTKN", "S100A10", "S100A11", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", 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0000000000000000000000000000000000000000..f4a3a5b280cfcc52db362a325247d6e2d16913b8 --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5ca0c32b0f419a65e7b160441abb40684f45c7cfa93cdbdaf3b6da1bdea124e6 +size 306891 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..111523ac5d411766b9351b287b55ee826af7822a --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 9 25 3.241117483605235 0.0011906210413472 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.0009972058726998 0.0015110215950041 6.847994005188295e-05 0.0010867399551646 0.0142204971286994 +Microtubule family cytoskeletal protein 6 43 3.086378344270427 0.0020261083713062 13.95388349514563 44.689320388349515 -0.1362213656804705 0.619784536589291 6.314208777929424 5.456410011879574 0.9169883864186168 0.3228121160578749 0.0012241493747278 0.0018506188949832 9.714238185978128e-05 0.0193356648235644 0.0966482219899011 +Tubulin 6 7 2.730276917747799 0.0063281145339988 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 8.038662837650203e-07 1.2604935566954765e-06 1.78057129080961e-10 1.171981080376947e-07 1.2638875700681251e-05 +SLC superfamily of solute carriers 13 41 2.281105125398623 0.0225422269265447 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 1.0 1.0 0.0979989328881401 0.0336954180915569 0.0164128898582906 +Other small molecule kinase 1 6 2.217762750318644 0.02657101317651 1.6067961165048543 4.87621359223301 0.1050165406566997 0.5224213534548736 1.4584046434589368 0.968793280528811 0.986745169262007 0.3023106065959564 0.0534900373740109 0.0595353304203936 0.1180585699575878 0.0385233102424958 0.1302253804689002 +SLC25 family of mitochondrial transporters 9 21 2.10722706689928 0.035097901800964 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 1.0 0.048990890514732 0.001886473535207 0.0003368638288124 +Reductase 3 16 2.062037631474357 0.0392041533750129 4.563106796116505 16.313106796116504 1.2016212969729014 0.3130807121312539 1.9089462498224232 1.180966799206311 0.8349037556988175 0.2876306629725971 0.1154979493875716 0.1280604643503683 0.031373049189738 0.0326106125072858 0.0507616506254266 +Calmodulin 3 14 2.021674085983241 0.0432100327209785 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 1.0 0.1403531442218371 0.0034893000144238 0.0071928662194731 0.0686432790956221 +Intracellular calcium-sensing protein 3 14 2.021674085983241 0.0432100327209785 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 1.0 0.1403531442218371 0.0034893000144238 0.0071928662194731 0.0686432790956221 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a875a9a7f1716c57cfe22b323dbcc06d12971441 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 1953, + "title": "Average number of proteins per term", + "value": 3.1546338965693805 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ef2e0c312fc7e618c818b9a87f4d27f57b10c902 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5710df3677131d2488995d5b9c09aa9a48473a6c --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,74 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.7470614853306526 3.241117483605235 0.0011906210413472 0.9023795480512844 0.1062939555354983 25 P20645,Q9GZP9,Q14108,Q9NR77,A6NIH7,Q8WTV0,Q567V2,Q9UQB8,Q13641 9 +Microtubule family cytoskeletal protein 0.6628538209669146 3.086378344270427 0.0020261083713062 0.9809560100802134 0.1062939555354983 43 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Tubulin 0.972130059721299 2.730276917747799 0.0063281145339988 0.999995873485346 0.1062939555354983 7 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +SLC superfamily of solute carriers 0.5619310523647787 2.281105125398623 0.0225422269265447 1.0 0.1218308730924459 41 Q9BSK2,Q8IXU6,Q9UBX3,Q9Y6M7,Q9NZJ7,Q8TB61,Q9H2D1,Q9BQT8,O43826,Q96NB2,P53985,Q70HW3,O43772 13 +Other small molecule kinase 0.8502215947481987 2.217762750318644 0.02657101317651 1.0 0.1288235196117897 6 P35790 1 +SLC25 family of mitochondrial transporters 0.6061638159259657 2.10722706689928 0.035097901800964 1.0 0.1450701294448134 21 Q9BSK2,Q9UBX3,Q9NZJ7,Q9H2D1,Q9Y6C9,Q9BQT8,Q70HW3,Q9Y619,O43772 9 +Reductase 0.6510984658290838 2.062037631474357 0.0392041533750129 1.0 0.152521337731873 16 P00374,Q9UDW1,Q15392 3 +Calmodulin 0.6637649681269453 2.021674085983241 0.0432100327209785 1.0 0.1592248941586247 14 Q9BPX6,Q02818,P80303 3 +Intracellular calcium-sensing protein 0.6637649681269453 2.021674085983241 0.0432100327209785 1.0 0.1592248941586247 14 Q9BPX6,Q02818,P80303 3 +Membrane trafficking regulatory protein 0.5551634091192045 1.9363622613196976 0.052823348169368 1.0 0.1728271327029183 23 P24390,O43760,P50542,Q96AX1,O00560 5 +Oxidase 0.5544437782401281 1.7211691990742508 0.0852201252456112 1.0 0.2283100058799881 20 O75880,P14406,Q15800,P49748,O15260,O43169 6 +Calcium-binding protein 0.5797781750493215 1.7109855267087346 0.0870837846620773 1.0 0.2310747790705221 17 Q9BPX6,P60660,Q02818,P80303 4 +Non-protein kinase 0.5575577803220919 1.6823298134700433 0.0925049030229974 1.0 0.2387439630691057 19 O00443,P35790,Q8TBX8 3 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.8246839837536339 1.6488097377861115 0.0991866193712893 1.0 0.2509215901970572 4 Q9UBX3 1 +SLC35 family of nucleotide sugar transporters 0.9754885723749588 1.618180391365888 0.1056237274046905 1.0 0.2565710691807967 2 Q8IXU6 1 +Phosphatase 0.4772464015048783 1.495419434539094 0.1348050115951067 1.0 0.2955006232871796 31 Q9Y217,Q13362,Q86YN1,Q9NPH0,P10586,O43681 6 +Acetyltransferase 0.4989664352833135 1.4900731242817258 0.1362050099118663 1.0 0.2968978973873462 22 Q9BWD1,P23786 2 +Translation elongation factor 0.7606615798746045 1.3958453785690297 0.1627610619719099 1.0 0.3297431058414317 4 Q53EL6 1 +Mitochondrial amino acid transporter subfamily 0.6789589616016924 1.3675305625528045 0.1714590643764322 1.0 0.3416019243419664 5 O43772,Q9Y619,Q9H936 3 +Protein arginine methyltransferase 0.7484255883327751 1.3472741563356427 0.17789195229102 1.0 0.3481192212668959 4 Q86X55,O60678,Q99873 3 +Translation factor 0.4545912008222196 1.3166787868811385 0.1879463171208262 1.0 0.3589744370609283 27 O75153,P29692,P55010,Q53EL6,P63241 5 +Metalloprotease 0.4401530641982964 1.2949460750628463 0.195338832505473 1.0 0.3675406107747715 40 Q9NZ08,O95630,Q7Z2K6,Q96KP4,P02786,Q92905,Q9UIQ6,Q8IYS1,P42892,P55786,Q5JRX3,Q9BPU6,P52888,O75844 14 +Mitochondrial nucleotide transporter subfamily 0.5787595590234967 1.2847037927860347 0.1988958124030129 1.0 0.3720723387194293 9 Q70HW3,Q9H2D1 2 +CDK4 subfamily 0.8668433256045083 1.1880504611252245 0.2348135297820062 1.0 0.4127730185996923 2 P11802 1 +Protein phosphatase 0.5169848905640573 1.184133194330233 0.2363603419696724 1.0 0.4130770019318435 13 Q13362 1 +Lyase 0.4833645520804311 1.1818828183967631 0.2372522003226664 1.0 0.4130770019318435 18 Q96KA5,O96005,P53701,P22830 4 +CDK family 0.5802956863516742 1.1755566848626984 0.2397720730711898 1.0 0.4147695825580459 8 P11802,Q00534 2 +Miscellaneous SLC25 mitochondrial transporters 0.8569062603511122 1.149145087420809 0.2504961593922399 1.0 0.4257780672698386 2 Q9NZJ7 1 +SLC4 family of bicarbonate transporters 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.4295410933423795 2 Q9Y6M7 1 +Cysteine protease 0.4098772887543833 1.0469449707036111 0.2951249591351912 1.0 0.4727057116321565 40 Q13510,Q96FW1,Q66K14,Q8NHP8,Q96K76,P17812,P07384,Q9NRF8,P51784,Q06203,Q93009,O94966,Q9Y4E8,P55210 14 +P-type ATPases 0.5693950289006093 1.0196245761027882 0.3079065448393543 1.0 0.484952808121983 7 Q8NB49,P05026,P23634,P16615 4 +Writer 0.4972748409008143 1.0072059528203403 0.3138358130175698 1.0 0.4923062994564769 11 Q86X55,O60678,Q9H7B4,Q99873 4 +Ion channel 0.5687677868765293 1.0026593441475564 0.3160252522445321 1.0 0.4945491327192078 6 Q4KMQ2 1 +Serine protease 0.4058024996528554 0.9578552675259538 0.3381357456802267 1.0 0.5135140834474984 28 P67812,Q9HB40,P42785,O14773,P10619 5 +Lipid kinase 0.6434861852061158 0.9333173491206492 0.3506561401077173 1.0 0.5239720287914091 4 O00443 1 +Protein methyltransferase 0.4814500539423074 0.8966506718507818 0.3699053501396663 1.0 0.5415480875732895 10 O60678,Q9H7B4,Q99873 3 +Cellular structure 0.3785543072793709 0.8809714468112836 0.3783332746314019 1.0 0.5490212449423469 101 Q9BVA1,P04350,Q9BUF5,P07437,Q13509,P68371,Q13885,Q16527 8 +Hydrolase 0.3742365517458783 0.866638355350342 0.3861401911404014 1.0 0.5557345565933707 98 P10253,Q9Y217,P50897,O43681,Q13362,P16278,Q86YN1,Q8NCC3,Q9NPF4,Q9NPH0,P10586,P15586,O00154,O43865 14 +Esterase 0.4502512215625452 0.7927812089272938 0.4279053064360927 1.0 0.5889898279068259 12 O00154,P50897 2 +Protease 0.3789487290527783 0.7636950252390248 0.4450490060562373 1.0 0.6002629204612095 113 Q9H3G5,Q96K76,P42785,P10619,Q96FW1,Q9HB40,O75844,P67812,Q9UIQ6,Q5JRX3,Q9Y4E8,Q9NZ08,Q8NHP8,P42892,O14773,Q9NRF8,Q92945,Q66K14,P52888 19 +Oxygenase 0.5103732825899776 0.7505406235264209 0.4529291668105895 1.0 0.6075347958661272 6 Q16850 1 +PIKK family 0.7469893987175258 0.7293519221852178 0.4657864189833407 1.0 0.616508232699126 3 Q13315 1 +Aspartic protease 0.7300430606161035 0.6750660850548126 0.4996337797733883 1.0 0.6383588057122515 2 Q8TCT9 1 +V-type ATPase 0.4808479618080908 0.6365018814978148 0.5244493550302218 1.0 0.6569913985721765 7 Q93050,P21281 2 +Translation initiation factor 0.3689676728879766 0.5823851462429328 0.5603072844058989 1.0 0.6809771091957191 21 O75153,P55010,P63241 3 +Epigenetic regulator 0.3538383746765112 0.575461941573348 0.5649789228266158 1.0 0.6830107121984718 30 Q99873,Q8NB78,Q16637,Q86X55,P26358,P25440,O60678,Q9H7B4 8 +Oxidoreductase 0.3586393027294707 0.5250795852629141 0.5995278670822897 1.0 0.7042403766981623 116 P00374,Q9Y6M9,P14406,Q9NZ01,O14548,Q16850,Q96CU9,P03886,P00403,Q8N4Q0,O43169,O75880,Q15800,P49748,Q9UDW1,O15260,Q14534,P00390,Q02252,Q15392 20 +Ca2+-ATPases 0.662925635020353 0.4700359755110855 0.6383293150551177 1.0 0.7303205344479466 3 P16615 1 +SLC3 and SLC7 families of heteromeric amino acid transporters (HATs) 0.6654521364690374 0.464623226243805 0.6422012964391484 1.0 0.7321497854015392 2 Q9UPY5 1 +KRAB box transcription factor 0.4439602460904045 0.4173944587653521 0.6763899073099888 1.0 0.7536534264195627 5 P49711 1 +C2H2 zinc finger transcription factor 0.4439602460904045 0.4173944587653521 0.6763899073099888 1.0 0.7536534264195627 5 P49711 1 +F-type and V-type ATPases 0.3570212615128371 0.4013435500130201 0.6881672042354192 1.0 0.758031895020741 16 Q93050,P00846,P21281 3 +Phosphatase modulator 0.4383289124668283 0.3983960312131046 0.6903382829557665 1.0 0.7595665727394997 5 Q92688,Q99733,P55209,Q15257 4 +Signaling 0.3483659399120359 0.3711374660144076 0.7105351467977281 1.0 0.7694209430728468 17 O15173,P43490,Q7Z4V5 3 +DNA helicase 0.3637778189282367 0.369352905156477 0.7118646962818729 1.0 0.7694209430728468 12 Q9H4L7,Q96RR1,Q14566 3 +DNA-directed DNA polymerase 0.4108994744974881 0.3658761145390292 0.7144575202832237 1.0 0.7704779332485565 7 P40938 1 +Other group 0.3393280398453041 0.2895850993877328 0.7721336677486783 1.0 0.8038257212756763 14 Q86UE8,Q9Y3S1,Q96KB5 3 +Phosphatase inhibitor 0.4381836261186485 0.249096673972397 0.8032860021730672 1.0 0.8261282581590312 4 Q92688,Q99733,P55209 3 +Transaminase 0.3659022858418269 0.2211008379920109 0.8250139177816855 1.0 0.8457636912614315 7 O15269,O15382,Q8TD30 3 +Kinase activator 0.4259197878687329 0.2205922562563062 0.8254099311542695 1.0 0.8457636912614315 4 Q16543,O95067,P14635 3 +Nucleotide phosphatase 0.3528891377624991 0.2198253745440772 0.8260071569331513 1.0 0.8459318182959855 8 Q5TFE4,O43681,Q8IWA4,Q9BY32 4 +Extracellular structure 0.3443630005728669 0.1942439263398752 0.8459848895730748 1.0 0.8641257789415351 8 Q92791,O75718,Q9BXS5 3 +Glycosyltransferase 0.2971016596978418 0.1312816282478029 0.89555252453524 1.0 0.912846597295054 16 P46976,Q16739,P15291,P35573 4 +CAMKL family 0.3715521776923757 0.1190009085030837 0.905274636015752 1.0 0.9222750986639352 4 O14757 1 +Histone deacetylase 0.4900596421471118 0.1167200687573719 0.9070818864097292 1.0 0.92363447557779 3 Q13547,Q8IXJ6 2 +Transcription cofactor 0.2975938541326135 0.1145708155730496 0.9087853131452376 1.0 0.9245515349131124 11 O00625,Q13363 2 +Bromodomain 0.3223382747737546 0.1117908478592169 0.910989244385372 1.0 0.9261644946822652 7 P25440,Q8WWQ0 2 +HDAC class I 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 0.9306829907493864 2 Q13547 1 +Na+/K+-ATPases 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 0.9375622993287196 3 P05026 1 +Unclassified protein 0.2784467872595232 0.0650157678624208 0.9481614458778748 1.0 0.9599581668219228 16 O75414,P30085,Q9BRR6 3 +Helicase 0.2638749942794309 0.043624309160961 0.9652038742318634 1.0 0.9746862287356924 22 P49736,Q9H4L7,Q8IX18,P46063,Q14566,P13010,Q96RR1,Q14562 8 +Nucleoside kinase 0.2879390324718301 0.0301907611396797 0.9759149167168792 1.0 0.9844844175351576 3 P55263,Q9BZX2 2 +Transporter 0.354629452490831 0.0276913038826396 0.977908359541867 1.0 0.9859860744374116 175 P08183,P24390,Q9UBX3,Q15334,Q9Y487,Q96AX1,Q8WUX9,P00846,P53985,P49257,Q96ES6,Q9BSK2,Q9BQT8,O43826,Q96NB2,Q9HD45,O14579,Q70HW3,Q9Y5P4,Q99805,Q8IXU6,Q99808,Q93050,Q8TB61,Q9H2D1,Q9UBQ0,O00560,Q9Y6M7,Q9NZJ7,Q92572,P21281,O43760,P50542,O43772 34 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f44ff4e83ac51559b39aa4a5c8324b5b2aa1ccd7 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L22, mitochondrial", "39S ribosomal protein L23, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-2", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-1 complex subunit sigma-2", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP synthase-coupling factor 6, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 2B", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "Abl interactor 1", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 2, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Anion exchange protein 2", "Anion exchangers", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 1", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arfaptin-2", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-1,4-galactosyltransferase 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "Bifunctional coenzyme A synthase", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 2", "CD166 antigen", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDK9 subfamily", "CDKN2A-interacting protein", "CHK1 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLK family", "CMGC group", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium-regulated heat-stable protein 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Caspase-7", "Catechol O-methyltransferase", "Catechol O-methyltransferase domain-containing protein 1", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Ceramide glucosyltransferase", "Cgmp-dependent protein kinase 1", "Chaperone", "Chaperonin", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Clathrin heavy chain 1", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 4", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collagen type IV alpha-3-binding protein", "Condensin complex subunit 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent kinase 9", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystathionine gamma-lyase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cystine/glutamate transporter", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A-related protein, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic 5'-nucleotidase 3A", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-2", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Dr1-associated corepressor", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 4", "Dual specificity protein kinase clk2", "Dual specificity protein kinase clk3", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase CBL", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase MARCH5", "E3 ubiquitin-protein ligase NEDD4", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase ZNF598", "E3 ubiquitin-protein ligase listerin", "EH domain-containing protein 1", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelial protein C receptor", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP41", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exostosin-2", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FAD-dependent oxidoreductase domain-containing protein 2", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "G2/mitotic-specific cyclin-B2", "GC-rich sequence DNA-binding factor 2", "GHMP kinase family", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GPN-loop GTPase 1", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIH subunit 1", "General transcription factor IIH subunit 4", "General vesicular transport factor p115", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate exchanger SLC37A4", "Glucose-6-phosphate isomerase", "Glucose-induced degradation protein 8 homolog", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutaminyl-peptide cyclotransferase-like protein", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate acyltransferase 4", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogenin-1", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-11", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "H/ACA ribonucleoprotein complex subunit 3", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock factor protein 1", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Hepatoma-derived growth factor-related protein 3", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase EHMT2", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase SMYD3", "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Huntingtin-interacting protein 1", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "ILK subfamily", "INSR family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-4", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit alpha", "Inhibitor of nuclear factor kappa-b kinase subunit beta", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol polyphosphate 5-phosphatase OCRL-1", "Insulin-degrading enzyme", "Insulin-like growth factor 1 receptor", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF15", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF20B", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lactadherin", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat-containing protein 47", "Leucine-rich repeats and immunoglobulin-like domains protein 2", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 3", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Long-chain-fatty-acid--CoA ligase 6", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 5", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAP7 domain-containing protein 1", "MAPK family", "MARK subfamily", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MSN subfamily", "MST subfamily", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 12", "Mediator of RNA polymerase II transcription subunit 21", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Metastasis-associated protein MTA3", "Methionine aminopeptidase 1", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylsterol monooxygenase 1", "Methyltransferase", "Methyltransferase-like protein 7B", "Mevalonate kinase", "Mevalonate kinase subfamily", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1A", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitogen-activated protein kinase kinase kinase kinase 4", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 6", "N-acetyl-D-glucosamine kinase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 50", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral cholesterol ester hydrolase 1", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-14", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear envelope pore membrane protein POM 121", "Nuclear envelope pore membrane protein POM 121C", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin GLE1", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase 6", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "OCIA domain-containing protein 2", "OTU domain-containing protein 7B", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PEK family", "PH-interacting protein", "PHD finger protein 10", "PHD finger protein 14", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PKA family", "PKG family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal bifunctional enzyme", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal targeting signal 1 receptor", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phospholipid-transporting ATPase IG", "Phospholipid-transporting ATPases", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plakophilin-2", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor CWC22 homolog", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presenilins-associated rhomboid-like protein, mitochondrial", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl 3-hydroxylase 3", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein HIRA", "Protein LSM14 homolog B", "Protein NDRG1", "Protein NDRG3", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein lin-28 homolog B", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Proto-oncogene tyrosine-protein kinase src", "Pseudouridine-5'-phosphatase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA binding protein fox-1 homolog 2", "RNA helicase", "RNA polymerase II elongation factor ELL", "RNA polymerase-associated protein LEO1", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein 7", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with multiple splicing", "RNA/RNP complex-1-interacting phosphatase", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor expression-enhancing protein 6", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "S1 RNA-binding domain-containing protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC35 family of nucleotide sugar transporters", "SLC37 family of phosphosugar/phosphate exchangers", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC4 family of bicarbonate transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC61 Molybdate transporter family", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Sec1 family domain-containing protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 1", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-6", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine-protein kinase atm", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 2", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 26", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase chk1", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase tousled-like 2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk2", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-coupled neutral amino acid transporter 1", "Sodium-dependent HCO3- transporters", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Sorbitol dehydrogenase", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Syntaxin-12", "Syntaxin-18", "Syntaxin-3", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 2", "Syntaxin-binding protein 3", "Syntenin-1", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "TK group", "TKL group", "TLK family", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Testin", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin, mitochondrial", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription factor SPT20 homolog", "Transcription initiation factor IIB", "Transcription initiation factor TFIID subunit 6", "Transcription initiation factor TFIID subunit 9B", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor CTCF", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Trophoblast glycoprotein", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-3 chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-specific chaperone A", "Tubulin-specific chaperone C", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase lyn", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin conjugation factor E4 B", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-Ie", "Unconventional myosin-VI", "Unconventional myosin-Va", "Upstream-binding protein 1", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4B", "Vacuole membrane protein 1", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "WEE family", "WNK family", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "YSK subfamily", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 1", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 3", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 148", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1A", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ANAPC1", "ANO6", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APP", "ARCN1", "ARFIP1", "ARFIP2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATIC", "ATL2", "ATM", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCKDK", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRD2", "BRD4", "BRIX1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC40", "CDC42", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CDKN2AIP", "CEBPZ", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHKA", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTOP", "CHUK", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLK2", "CLK3", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNP", "COASY", "COIL", "COL4A3BP", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "CORO1B", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7A2L", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CWC22", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCP1A", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHX15", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DSC2", "DSG2", "DSP", "DTYMK", "DUSP11", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELL", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMG1", "ENO1", "EPHA7", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FNTB", "FOXC1", "FOXRED1", "FOXRED2", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GID8", "GLB1", "GLDC", "GLE1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPN1", "GPR107", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2H1", "GTF2H4", "GTF3C3", "GTF3C5", "GTPBP1", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEO1", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRIG2", "LRRC47", "LSM14B", "LSM2", "LSM6", "LTN1", "LYN", "M6PR", "MACF1", "MAGED2", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MARS2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED12", "MED21", "METAP1", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MORF4L1", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL38", "MRPL39", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTA3", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MUT", "MVK", "MYBBP1A", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCEH1", "NCL", "NCOA5", "ND1", "NDRG1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NEDD4", "NEK9", "NFS1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OLA1", "OPA1", "ORC3", "ORC5", "OSGEP", "OTUB1", "OTUD7B", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PATL1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF10", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIK3C2A", "PIK3R4", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLDIP3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA2", "PRKACA", "PRKAG1", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP2B", "RAPGEF2", "RAVER1", "RBBP6", "RBFOX2", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBM7", "RBMX", "RBPMS", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RNASEH2A", "ROCK1", "RP2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTCA", "S100A10", "S100A11", "SAE1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP23", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STK26", "STK4", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TAP1", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "THOC1", "THOC2", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED7", "TMED9", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM3", "TPP1", "TPP2", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRMT6", "TROVE2", "TSFM", "TSG101", "TST", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXN2", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UBE4B", "UBP1", "UCHL5", "UCK2", "UGCG", "UGGT1", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VRK1", "VRK3", "WARS", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR82", "WIZ", "WNK2", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF148", "ZNF207", "ZNF281", "ZNF598", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ACADVL", "ACAT2", "ACOT7", "ACP6", "ADK", "ADPGK", "AGL", "AHCYL1", "ALDH6A1", "ANO6", "ANP32B", "AP1M1", "AP3S1", "ASAH1", "ASNA1", "ATM", "ATP11C", "ATP1B1", "ATP2A2", "ATP2B4", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V1B2", "B4GALT1", "BAIAP2", "BCAT2", "BRD2", "CAPN1", "CARM1", "CASP7", "CCNB1", "CCNB2", "CDC37", "CDK4", "CDK6", "CHEK1", "CHKA", "CHMP7", "CLPTM1", "CLPTM1L", "CLUH", "CMPK1", "CNDP2", "COL4A3BP", "COPE", "COPS5", "COX2", "COX7A2", "COX7A2L", "CPT2", "CPVL", "CRTAP", "CSRP2", "CTBP1", "CTCF", "CTPS1", "CTPS2", "CTSA", "CYB5B", "CYP51A1", "DERL2", "DHCR24", "DHFR", "DHX40", "DHX8", "DNMT1", "DOLPP1", "DPYSL5", "ECE1", "EEF1D", "EIF5", "EIF5A", "ERAP1", "ERMP1", "FECH", "FOXRED1", "GAA", "GLB1", "GNS", "GPT2", "GSR", "GYG1", "HCCS", "HDAC1", "HDGFL2", "HM13", "ITPA", "KDELR1", "KDM1B", "KHSRP", "LLGL1", "LMAN1", "LNPEP", "M6PR", "MCM2", "MCM6", "MFN1", "MFSD3", "MICU1", "MPV17L2", "MSMO1", "MTCH1", "MTCH2", "MTMR6", "MYL6", "NAMPT", "NAP1L1", "NAP1L4", "ND1", "NDUFB9", "NME6", "NPEPPS", "NT5DC1", "NUCB1", "NUCB2", "OSGEP", "OTUB1", "P3H4", "PBK", "PDCD4", "PEX5", "PGRMC2", "PHIP", "PIK3C2A", "PIP4K2C", "PIR", "PITRM1", "PLA2G15", "PLBD2", "PM20D2", "PPAT", "PPP2R5C", "PPT1", "PRCP", "PRMT1", "PRMT3", "PTPA", "PTPRF", "PXMP2", "RECQL", "RFC3", "SCARB1", "SCARB2", "SCO1", "SCPEP1", "SDCBP", "SEC11A", "SFXN2", "SIRT2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A33", "SLC29A1", "SLC35B2", "SLC35F2", "SLC37A4", "SLC4A7", "SLC7A11", "SMARCAD1", "SMN1*", "SMYD3", "SPTLC1", "SQLE", "STAMBP", "SURF4", "SYNGR2", "TBC1D9B", "TECR", "TFRC", "THOP1", "TLK2", "TM9SF2", "TM9SF3", "TPBG", "TPP1", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TWNK", "UCK2", "UGCG", "UNC119B", "UQCR10", "USP11", "USP15", "USP19", "USP47", "USP7", "VPS29", "VPS33A", "WNK2", "XRCC5", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..54fda4adf4dca5621f67c412f6e6542ef9c182c6 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3ae76c1b4da14fdd950a71584101a8963ff332d75010853f22e27a0efa60469e +size 188133 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..7e80dec85637334a944997753afa3d6d3cb45060 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ad4bbeb373bcaf177ea59fabb5e55478990b5a26d1f9e65a20b2662597ce7e0c +size 129687 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..fd042408c4b4faa68ac7447ee72b86d2d59d35a3 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1d63e9db345cc63ea9b342ee6dd2017da4293a5447148d72a0f04b4ff1999a74 +size 75620 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c5f08db0c7595b94ff09f0a5d74560f8e37c3512 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tclin 16 82 2.786923595626292 0.0053211023161754 19.366504854368937 86.39077669902913 0.9399778874953114 0.4805096456956057 6.659845213621253 7.009024167820235 0.9745051203556824 0.3806460486794667 0.000287697760485 6.672387342646413e-05 7.598057580105006e-06 6.2661654259862e-06 2.355621944925149e-05 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2636ac8311897625151408a4e53608d40fa4fbfa --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 755.0 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b118c20ecb95cf60ae5e3608a2241e61d381c8c1 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4da92d2a47255ab01a06d32369103c42bc90298a --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.544910142655717 2.786923595626292 0.0053211023161754 0.0211151263333844 0.0106422046323508 82 P00374,P10253,Q9BVA1,P11802,P04350,Q9Y6M9,P20618,P03886,Q9BUF5,P07437,P49721,Q16739,Q13509,P68371,Q99720,Q13885 16 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..028fd331ff9367c748c592c53f2a29cce7fcef37 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD2", "BRD4", "BRIX1", "BROX", "BSDC1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf57", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C2orf49", "C3orf58", "C5orf15", "C5orf51", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC134", "CCDC138", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC97", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COA7", "COASY", "COG1", "COG3", "COG8", "COIL", "COL4A3BP", "COLGALT1", "COMMD2", "COMMD8", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM129B", "FAM162A", "FAM208A", "FAM210B", "FAM213A", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LENG8", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRCH2", "LRIG2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NEO1", "NES", "NFATC2IP", "NFS1", "NFU1", "NGDN", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIPSNAP3A", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", 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"PUM3", "PURA", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC37A4", "SLC38A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", 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0000000000000000000000000000000000000000..75a500c1d173641f011002f595978d2983e47e86 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..353f3e89e06fb65b4bcf730a6d3d36df24719dac --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,53 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Phospholipid metabolism 0.6957814558125726 2.128293626072898 0.0333127462514317 0.9965105200726986 0.2528740283631411 13 Q96N66,P35790,Q99943,Q9NPH0,Q8WUK0 5 +Sphingolipid metabolism 0.6830731261380184 1.9577125328713727 0.0502637537909398 0.9998181542468352 0.3357618753234781 11 P07602,P04062,Q9NZ01,O95470,Q16739,Q13510 6 +Ion transport 0.4787431858974368 1.8601470773266944 0.0628647201916452 0.9999804574123994 0.3749741940090833 50 Q9BPX6,P21796,P45880,Q9Y6M7,Q93050,P21281,Q9C0H2,P00846,O75964,Q4KMQ2 10 +Translocation 0.4947363207861113 1.8464734513503511 0.0648234907551588 0.99998622062879 0.3749741940090833 45 Q15629,O60830,Q99595,Q9BTX1,Q9NS69 5 +Phospholipid biosynthesis 0.6359401254666371 1.7699609765490771 0.0767336417253716 0.9999983796424338 0.3749741940090833 12 Q99943,P35790,Q8WUK0,Q96N66 4 +Sterol metabolism 0.5277197375673588 1.7534395503856437 0.0795265871763346 0.9999990230360422 0.3749741940090833 23 P04062,O15118,Q15800,Q16850,Q15392 5 +One-carbon metabolism 0.6463167853776858 1.729324784861304 0.0837509831846332 0.999999546833172 0.3749741940090833 10 P00374 1 +Steroid metabolism 0.5118866610769304 1.7242524901496932 0.0846622719949159 0.999999616215288 0.3749741940090833 24 P04062,O15118,Q15800,Q16850,Q15392 5 +Vision 0.8418785467556622 1.7162071583966525 0.0861241334952391 0.9999997061241812 0.3749741940090833 4 P50897 1 +Sensory transduction 0.8418785467556622 1.7162071583966525 0.0861241334952391 0.9999997061241812 0.3749741940090833 4 P50897 1 +Cholesterol metabolism 0.5319673567141294 1.7083639946573643 0.0875688237506242 0.9999997743582976 0.3749741940090833 22 P04062,O15118,Q15800,Q16850,Q15392 5 +Lipid biosynthesis 0.4627119406922756 1.6277388425514527 0.1035802732019426 0.9999999882671192 0.4324476406181105 47 Q96N66,P35790,Q9NZ01,Q15800,Q15392,Q16739,Q96G23 7 +Lipid transport 0.5409746652717865 1.5306362283478818 0.1258593227726825 0.9999999998245788 0.4888024861171624 18 Q9Y5P4,Q99720,O15118 3 +Endocytosis 0.4563220707958957 1.3349346346959745 0.1818977408969544 0.9999999999999972 0.6031106702644671 30 Q8NC96,O00443,Q15642,Q9Y217,Q96CW1,P02786,Q9Y5X1,P05067 8 +Unfolded protein response 0.5854348258353648 1.3171303383520132 0.1877949392440256 0.9999999999999992 0.6031106702644671 9 Q15629 1 +Respiratory chain 0.4466655195038992 1.2605154664976737 0.2074834720404967 1.0 0.6364228583922356 29 Q9Y6M9,Q86Y39,P03886,O14949,Q9UDW1,Q96CU9 6 +DNA excision 0.8814176879761548 1.245340436958816 0.2130066376293251 1.0 0.6364228583922356 2 Q9UQ84 1 +Symport 0.5939564492054876 1.1289501495520349 0.2589188635467989 1.0 0.6551431850350822 7 Q9Y6M7 1 +Electron transport 0.4032667302265564 1.0481687425530524 0.2945608690198662 1.0 0.6985626349457719 44 Q9H1E5,Q9Y6M9,Q86Y39,P03886,P00403,O14949,O43396,Q9UDW1,O43169,Q96CU9 10 +Sterol biosynthesis 0.4707383115725386 1.0079345471296763 0.3134858852280606 1.0 0.7026172058251368 15 Q15800,Q16850,Q15392 3 +Cholesterol biosynthesis 0.4770161290739274 1.0036514432508634 0.3155466493226662 1.0 0.7026172058251368 14 Q15800,Q16850,Q15392 3 +ATP synthesis 0.5315921904280492 0.9494320984369806 0.3424008915262675 1.0 0.7330890882677779 8 P00846 1 +Glycogen biosynthesis 0.8025182239893978 0.9175314644103824 0.3588642129099382 1.0 0.7527010004014082 3 P46976,P35573 2 +Inflammatory response 0.4837707909308297 0.9083423905394732 0.3636973526209388 1.0 0.7527010004014082 10 P09429,Q12904,Q8IV08 3 +ER-Golgi transport 0.388289390235401 0.905722932755024 0.3650825211527788 1.0 0.7527010004014082 43 Q15436,P24390,Q9Y282,O95197,O14579,P49257,O95070 7 +Purine biosynthesis 0.4962104419914216 0.8842568329915925 0.3765575849653646 1.0 0.757652008303806 9 Q06203,P30566,P30520,P22102 4 +Pyrimidine biosynthesis 0.5210414424516098 0.795822189600359 0.4261353924258251 1.0 0.8372307121777975 6 Q9NRF8,P30085 2 +Immunity 0.3316448864288587 0.6890258532791144 0.4908069983178023 1.0 0.8829351148133253 73 Q96J02,Q8WXF1,Q13309,Q9Y3Z3,Q96FW1,Q9BY67,P26583,P46379,Q7Z7L1,Q9UQ84,Q8IV08,O00743,Q9H2U1,Q14166,O00584,P09429,P17812,Q9NUD5,Q9NZ08,Q15233,O14802,O15347 22 +Chemotaxis 0.559248255549964 0.6183086796831873 0.5363718814766272 1.0 0.9026708296842192 4 P09429 1 +Apoptosis 0.3573168665592719 0.5590399448160642 0.5761344592162403 1.0 0.9429394226419388 111 P46379,P21796,Q96KA5,Q9BY67,O95197,Q9NZJ7,Q9UDX5,P09601,O95470,P05067,Q53EL6,P42858,Q96A26 13 +Lipid degradation 0.3939241430492206 0.5534216571716802 0.5799747124662114 1.0 0.9429394226419388 14 Q15102,Q8NHP8,Q8NCC3 3 +Ubl conjugation pathway 0.3563967236996369 0.5496481127869485 0.5825607520436589 1.0 0.9429394226419388 111 Q96J02,Q9UPN9,Q9Y3C8,Q96K76,Q8TBC4,Q13042,Q13309,Q96DY7,P61088,Q9HB71,Q93009,Q96HY6,O95630,Q96FW1,Q86UV5,P30260,P19474,Q9NT62,Q15018,O94966,O75150,O94822,Q86WB0,Q14527,Q13356,Q9NUQ7,Q15345,Q96GG9,O75155,Q9Y4E8,P61962,Q13617,Q9UBE0,Q15386,P14373,P51784,Q92890 37 +Steroid biosynthesis 0.3673902675053387 0.5411023002333117 0.5884370728608597 1.0 0.9429394226419388 20 Q15800,Q16850,Q15392 3 +Hydrogen ion transport 0.3657137669438915 0.5310881372233384 0.5953577043420837 1.0 0.9429394226419388 20 P00846,O75964,Q93050,P21281 4 +Cilium biogenesis/degradation 0.3775469873124801 0.5265408921023885 0.5985124479044641 1.0 0.9429394226419388 17 Q9Y5Y2,Q9P1Y5,Q8NCM8,Q6IBS0,A6NIH7,Q9H4M9 6 +Neurogenesis 0.3362068410768634 0.4961965570675791 0.6197557398782987 1.0 0.9434254115164282 45 Q9BVA1 1 +Angiogenesis 0.3822442204114625 0.4723837377073344 0.6366529098839382 1.0 0.9492949638448008 13 P35613,O14786,Q13685,Q12948 4 +Potassium transport 0.5094858030197393 0.4501234722456614 0.6526214129020365 1.0 0.953359151183166 4 P05026,P05023 2 +Nucleotide metabolism 0.3784226378037502 0.4064656474615415 0.684400492948106 1.0 0.953359151183166 10 O43598 1 +Coenzyme A biosynthesis 0.6439218284200154 0.4020268579544018 0.6876642602749423 1.0 0.953359151183166 2 Q9NVE7 1 +Cell shape 0.4150594819888731 0.3777941353109516 0.7055835307585954 1.0 0.9579873954202068 6 P35580,Q7L576,Q96AC1 3 +Notch signaling pathway 0.4001979823503284 0.3274884675257741 0.7432984640949651 1.0 0.9851608394063536 6 P05067,Q92542,Q9NVX2 3 +GMP biosynthesis 0.6127856906260452 0.319702095273339 0.7491941712850714 1.0 0.9851608394063536 2 P49915 1 +Fatty acid metabolism 0.2832073597168112 0.126881636664516 0.8990340809807225 1.0 1.0 49 P23786,Q8NCC3,Q9NZ01 3 +Adaptive immunity 0.298056738666697 0.1254928514863181 0.9001333839893695 1.0 1.0 14 Q9NZ08,Q96FW1 2 +Autophagy 0.2815519218485934 0.1097609697869458 0.9125989455586664 1.0 1.0 31 Q96GC9,P62820,Q9HAD4,Q9NT62,Q96AX1,P09429,Q9Y4P8,Q7Z3C6 8 +Oogenesis 0.4865849619079282 0.1022900549359076 0.918526448913423 1.0 1.0 2 Q15645 1 +Sodium/potassium transport 0.4697214079010355 0.0952445992081014 0.9241205459333256 1.0 1.0 3 P05026 1 +Lipid metabolism 0.3153611111819278 0.0751779612335115 0.9400731191121444 1.0 1.0 121 P35790,Q8NCC3,Q9NZ01,Q9NPH0,Q16850,Q15102,Q14739,O95864,O15118,P43034,Q96G23,Q9Y217,Q15800,Q99943,P23786,P49748,Q9Y6X9,O00154,Q13510,P07602,Q8NHP8,P04062,Q96N66,A1L0T0,O95470,Q15392,Q16880,Q16739,Q8WUK0 29 +Hearing 0.4435243458098795 0.0693731947377115 0.9446925650027604 1.0 1.0 2 Q9UM54 1 +Transcription termination 0.3803843605036399 0.0426099360337049 0.9660124748757416 1.0 1.0 3 Q9H0D6,Q08211 2 +Exocytosis 0.261466345289769 0.0159671760369109 0.9872605780836056 1.0 1.0 14 O00443 1 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..1f1cae5d2204ea0f296d986f9fe335a9609bb4e4 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Anion exchange", "Antiport", "Antiviral defense", "Apoptosis", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Blood coagulation", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Cysteine biosynthesis", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Hemostasis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALKBH5", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANO6", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP2", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARMT1", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATRX", "AUP1", "BABAM1", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BICD2", "BIRC6", "BMS1", "BOD1L1", "BOP1", "BPTF", "BRAT1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "C2CD5", "CACYBP", "CAD", "CADM1", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARM1", "CARS", "CASP7", "CBL", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC86", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC16", "CDC23", "CDC27", "CDC34", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "COASY", "COG1", "COG3", "COG8", "COL4A3BP", "COMMD2", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPZ1", "COQ3", "COQ8A", "COQ9", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCP1A", "DCP2", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DPF2", "DPY30", "DPYSL2", "DRAP1", "DSC2", "DSG2", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "EP300", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM210B", "FAM50A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP15", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FRYL", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCC2", "GCFC2", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GHITM", "GID8", "GINS3", "GINS4", "GLE1", "GLRX", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPHN", "GPI", "GPKOW", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSPT1", "GSS", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HK1", "HK2", "HLA-A", "HLTF", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN5", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INTS13", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JMJD6", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIDINS220", "KIF11", "KIF18B", "KIF20A", "KIF20B", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LEO1", "LETM1", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPGAT1", "LRPPRC", "LRRC41", "LRRC8A", "LRRC8C", "LRSAM1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MANF", "MAP1S", "MAP2K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MESD", "MFGE8", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MIA3", "MICU1", "MIF", "MKI67", "MLEC", "MMGT1", "MMS19", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPP5", "MRE11", "MRPL41", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVK", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCEH1", "NCKAP1", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEK9", "NELFA", "NELFCD", "NELFE", "NEO1", "NES", "NFS1", "NGDN", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NMD3", "NME1", "NME2", "NME6", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPM1", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCDH7", "PCK2", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDK1", "PDK3", "PDS5A", "PDS5B", "PDZD8", "PECR", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIN1", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLIN3", "PLK1", "PLRG1", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "POP1", "POP4", "PPAT", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKAG1", "PRKDC", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPMT1", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PVR", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB35", "RAB39A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCOR1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RIOX2", "RMDN3", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRS1", "RSF1", "RTCB", "RTKN", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINH1", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SPATA5", "SPECC1L", "SPEN", "SPTLC1", "SPTLC2", "SRC", "SRCAP", "SREK1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", 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sha256:d687507414864f9b7ba23136d76236b3d40dcaca860dd6713b31e76bc4404a5c +size 70430 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..05a5ed68dc02f935201c41d8e0d1c176043c08ef --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mucopolysaccharidosis 4 5 2.348815707172994 0.018833225765793 2.254854368932039 4.752427184466019 0.4843930061917075 0.2034155563537636 0.9831595235232706 0.7286567852681505 1.626107445717624 0.2463507210616131 0.0454466093947272 0.0506073598520519 0.1008375048293403 3.3521637524966083e-06 9.8492817269125e-05 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..faf9a984c34b2899cee10370bb85a55a4954c7aa --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 115, + "title": "Average number of proteins per term", + "value": 20.713043478260868 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f8ffc62fb96d6573dcfdd75945bdc65b04c8d3a1 --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..498a012aff0b77b22ad88ed6cfbe93672e240b72 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,40 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mucopolysaccharidosis 0.9174403183023888 2.348815707172994 0.018833225765793 0.8876880934320726 0.338095775036078 5 P16278,P54802,P08236,Q96AX1 4 +Leber hereditary optic neuropathy 0.9847631666114608 1.6549683136012814 0.0979309255635141 0.999992878420414 0.8028459471637519 2 P00846 1 +Glycogen storage disease 0.6347066501328427 1.555008604864942 0.1199440199883727 0.9999995843916084 0.8028459471637519 9 P10253,P35573 2 +Neuronal ceroid lipofuscinosis 0.9526176275679276 1.453498866706886 0.1460852941203447 0.9999999870381592 0.8028459471637519 3 O14773,P50897 2 +FDA approved drug targets 0.4467026613670707 1.4393732134833193 0.150044809505601 0.9999999924047251 0.8028459471637519 117 P00374,P11802,P39023,Q16850,P68371,Q99720,P20618,P03886,P07437,P05067,P49721,P49356,P23786,Q13509,P10253,Q14534,P20645,P00390,P21281,Q16739,O00764 21 +Gaucher disease 0.9254720105995378 1.4196129058852534 0.1557204060645349 0.9999999964850136 0.8028459471637519 2 P04062 1 +Spinocerebellar ataxia 0.549524807456578 1.242476151593022 0.2140609342087498 0.9999999999990672 0.8028459471637519 10 Q8IV08 1 +Primary microcephaly 0.5403172245629988 1.1955857778574128 0.2318582441905234 0.999999999999933 0.8028459471637519 10 Q96T60,Q86XL3,Q00534,Q15003,Q15058,P35606 6 +Alzheimer disease 0.7081460032603246 1.187399594892251 0.2350700397243197 0.9999999999999588 0.8028459471637519 4 P03886 1 +Amyloidosis 0.7081460032603246 1.187399594892251 0.2350700397243197 0.9999999999999588 0.8028459471637519 4 P03886 1 +Epilepsy 0.3767407696878102 1.1843181546163843 0.2362871449608925 0.9999999999999656 0.8028459471637519 58 Q8NC96,Q13510,P37287,Q96T60,Q05639,Q96CW1,O14773,Q9NPF4,P03886,Q14108,O75503,Q9Y4G8,Q8IWS0 13 +Gangliosidosis 0.5865141123495711 0.9747186817015115 0.3296998235092243 1.0 0.8028459471637519 5 P16278 1 +Hypotrichosis 0.5698475687532292 0.904892196660962 0.3655225014368093 1.0 0.8028459471637519 5 P62304,Q8IWS0 2 +Hirschsprung disease 0.7903279231533689 0.8935733688048338 0.3715502004501614 1.0 0.8028459471637519 2 P42892 1 +Leukodystrophy 0.4384181518003952 0.8488429840668466 0.3959686684046091 1.0 0.8131499440451794 16 Q9NR50,P07602,P04350,O14802,Q13155,Q12904,P49770 7 +Hereditary nonpolyposis colorectal cancer 0.7721099701888081 0.8258747071169702 0.4088751697070618 1.0 0.8249235880054756 2 P52701 1 +Retinitis pigmentosa 0.4016723245920282 0.6402545574141629 0.5220071188488773 1.0 0.9008318445137674 16 P00846 1 +Dystonia 0.556800401442112 0.6096375057612603 0.5421019609380195 1.0 0.91144445580351 4 P04350 1 +Xeroderma pigmentosum 0.7052003974826166 0.5905943112215905 0.5547922774456149 1.0 0.91144445580351 2 P19447 1 +Cockayne syndrome 0.7052003974826166 0.5905943112215905 0.5547922774456149 1.0 0.91144445580351 2 P19447 1 +Cataract 0.3499965173016542 0.5781195627927623 0.5631834002486742 1.0 0.9121984651915146 24 Q15800,Q9H6K4 2 +Disease variant 0.2598556615720543 0.5207547363580183 0.6025376384161851 1.0 0.9562942792378452 760 P00374,Q9BVA1,Q9NZ01,Q14108,P10619,P00846,P68371,Q99720,Q13885,Q96CU9,P04350,P16278,O15118,P03886,P07437,Q70HW3,Q9Y5P4,O75844,Q8IV08,P50897,Q9H2D1,Q9BUF5,Q15800,P23786,Q9H6K4,P49748,O14949,Q13509,P10253,Q86UE8,P04062,Q96N66,P62304,P42892,O15382,O14773,Q9NPF4,P21281,Q02252,Q15392,Q8NCH0,O43772,Q9Y223,O00443,Q9UBX3,P11802,Q9Y6M9,Q86XL3,Q6UX04,P49711,O75503,P08236,Q96AX1,P42858,Q9Y3Z3,P28070,Q2M389,P16435,P00403,P05067,Q6ZXV5,P62266,P49366,O75880,P54802,Q9NUQ7,Q9Y6X9,Q6DKJ4,Q96T60,P07602,P00390,Q96AY3,P22830,O95470,P50542,P15586,O00764,Q9Y5P6,Q8TAA9,P53985,Q14739,Q09472,P27635,P04066,Q9BQT8,P43034,Q2TAA5,Q8IWS0,Q12948,Q9BW83,Q08J23,P35270,Q96F86,O75718,Q13510,Q15436,Q05639,P53701 98 +Cardiomyopathy 0.3463540366466073 0.5117770971534127 0.6088070210652461 1.0 0.9562942792378452 23 P00846 1 +Dwarfism 0.3310930814504762 0.4373841449558906 0.6618327806056672 1.0 0.9562942792378452 43 Q96PZ0,O00443,P48651,P49589,O75718,O00116,Q96ST3,Q6UX04,P12004,Q96HY6,Q9NUQ7,P19447,P29401,Q32P28,P09884,Q14739,P62266,Q6DKJ4 18 +Diamond-Blackfan anemia 0.3660559752107444 0.4345498026366063 0.6638892378115033 1.0 0.9562942792378452 15 P61254,P61313,P08708,P62847,P46783,P62244,Q07020,P18077,P46777 9 +Ichthyosis 0.4133833414914338 0.3746603818006248 0.7079130602489316 1.0 0.9641151318411808 7 P19447,P51648,Q10567,P04062 4 +Rhizomelic chondrodysplasia punctata 0.6148245879842817 0.3429058471924164 0.7316692927567652 1.0 0.9641151318411808 3 P50542 1 +Microphthalmia 0.4038451743825409 0.3413404365739568 0.732847309856097 1.0 0.9641151318411808 7 P53701,P41227,O15347,O60493,A6NHR9 5 +Ciliopathy 0.3349745444531411 0.2340263111953062 0.8149645523875044 1.0 1.0 10 Q8NCM8,Q9BW83,P49454,Q15058 4 +Tumor suppressor 0.2910284491695616 0.1786161821113672 0.858239087341234 1.0 1.0 28 Q53EL6,P49711 2 +Primary mitochondrial disease 0.2935180026511772 0.1325659465410991 0.8945366653894562 1.0 1.0 91 O75880,Q9UBX3,O75879,Q9Y6M9,Q86Y39,Q9NPL8,P03886,P00403,Q9BQT8,Q96IX5,Q96RR1,O14949,Q96CU9,P00846,Q70HW3 15 +Hermansky-Pudlak syndrome 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Albinism 0.4978469691951116 0.1139875861389685 0.9092476341266816 1.0 1.0 2 O00203 1 +Schizophrenia 0.4607485922491051 0.0804501422467494 0.9358792483614912 1.0 1.0 2 Q9NTZ6 1 +Alport syndrome 0.4438555813183339 0.0695624376103879 0.9445419349290828 1.0 1.0 2 P35579 1 +Li-Fraumeni syndrome 0.3945014905597973 0.0498388196655761 0.9602508314869068 1.0 1.0 2 O96017 1 +Oncogene 0.3959575878064878 0.0478034628338422 0.9618728767711155 1.0 1.0 3 Q96Q89,Q9H8V3 2 +Nemaline myopathy 0.3020867837032249 0.0397627745004475 0.9682822543911072 1.0 1.0 2 Q9Y281 1 +Charcot-Marie-Tooth disease 0.2493108314215882 0.0082501163353317 0.9934174342243824 1.0 1.0 24 Q9Y6X9,P54802,O00764 3 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b2b94ce73450a6c38d7ab6b7bb36fa0cd30c52ac --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amyloidosis", "Amyotrophic lateral sclerosis", "Aortic aneurysm", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary multiple exostoses", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ABI1", "ACAA1", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKR1B1", "ALCAM", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ANAPC1", "ANK3", "ANKLE2", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP1S2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "APEX1", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARL2", "ARL3", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATM", "ATP11C", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATRX", "ATXN10", "ATXN2", "B4GALT1", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDK", "BCL10", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BMS1", "BPTF", "BRAT1", "BRD4", "BUB1B", "C12orf57", "C19orf70", "C1QBP", "C3orf58", "CAD", "CADM1", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CC2D1A", "CCAR1", "CCAR2", "CCDC47", "CCDC6", "CCNB1", "CCNB2", "CCT5", "CDC16", "CDC27", "CDC34", "CDC37", "CDC42", "CDC6", "CDC73", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CENPF", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHMP1A", "CHP1", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNOT1", "CNOT2", "COA3", "COA7", "COASY", "COG1", "COG8", "COL4A3BP", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COQ9", "COX14", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTH", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC27", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DARS", "DARS2", "DAXX", "DBN1", "DBT", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJB11", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSC2", "DSG2", "DSP", "DYNC1H1", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "ECT2", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHHADH", "EHMT1", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELL", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EP300", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXT2", "EZR", "FADS2", "FAF1", "FAH", "FAM120A", "FAM210B", "FAM50A", "FANCI", "FAR1", "FARSB", "FASN", "FASTKD2", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP14", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GCLM", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI3", "GNE", "GNPAT", "GNS", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPHN", "GPI", "GPT2", "GRB2", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2H1", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIP1", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF1R", "IGF2R", "IKBKB", "ILF3", "ILK", "IMPDH2", "INF2", "INTS1", "INTS12", "IPO7", "IRS4", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIDINS220", "KIF11", "KIF14", "KIF1A", "KIF20B", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KMT2A", "KNL1", "KTN1", "L2HGDH", "LACTB", "LAMB1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRPPRC", "LRSAM1", "LSS", "LTA4H", "LYN", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAN2B1", "MAP1A", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK3", "MARS", "MARS2", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED12", "MED17", "MED23", "MESD", "MFGE8", "MFN2", "MGME1", "MICU1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMACHC", "MOGS", "MORC2", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTOR", "MTPAP", "MTR", "MUT", "MVK", "MYH10", "MYH14", "MYH9", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCKIPSD", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEFL", "NEK9", "NEO1", "NFU1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NME2", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPM1", "NRP1", "NSD1", "NSD2", "NSDHL", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NTHL1", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OTULIN", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDHA1", "PDHB", "PDK1", "PDK3", "PDXK", "PEPD", "PEX14", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIN1", "PISD", "PKM", "PKP2", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA6", "PNPT1", "POGLUT1", "POGZ", 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sha256:9de98000641b92a5affadad5d4719bb17e270c6bbf49027bd7fedf527498f619 +size 143488 diff --git a/protein_atlas_molecular_function/consensus.joblib b/protein_atlas_molecular_function/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..706e9221c282b2f3348de7617e1556dbe436c6cc --- /dev/null +++ b/protein_atlas_molecular_function/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3da09f2b10fecec0664a4cb85943ed466852e6e836d52378a27d369fa2d4d57d +size 73793 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..26baac7172429a978608be8c6cf792f3f659e398 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 10 35 2.7806739648517462 0.0054246186559088 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0038307885013848 0.0010593374405738 0.0331776056462107 0.1561261896895651 0.6828473422378039 +Carboxypeptidase 4 6 2.443111064462939 0.0145612553269842 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 3.069023402994854e-05 4.282287459858128e-05 0.0003602808960722 0.0003774704498572 0.000543833852376 +Protease 25 81 2.4105810124618605 0.0159271336858117 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.0723583610338619 0.0936030661724457 0.0066034650407422 0.0004917950747028 5.501272588202353e-05 +Host cell receptor for virus entry 2 14 2.33520001536489 0.0195329743435321 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0134432571670497 0.0009882311528957 0.0075361578498098 0.0816409424117451 0.1473962800256471 +Guanine-nucleotide releasing factor 2 11 2.079798966658332 0.0375439759362912 3.1990291262135924 16.21359223300971 0.5547832364838432 0.4500807259710942 2.2927066780931713 4.394171968646284 0.9520620002287806 0.2997519109124153 0.4122937107121848 0.1169514564297134 0.1188989579434368 0.590037064616693 0.8660462227857999 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1a28d79998e8985deb27e65a7f69792a03e60ed9 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 95, + "title": "Average number of proteins per term", + "value": 38.49473684210526 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2a043010ecadf343ac3c6ac4f96ecb0d0000475e --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ab419effc4cff43d20a3bd6b22233da4581a04ac --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,31 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6497334740170981 2.7806739648517462 0.0054246186559088 0.4035391103587925 0.1285376482547318 35 P20645,P24390,Q99720,O15118,Q14108,P10586,Q8WTV0,Q14739,O15173,Q9NS69 10 +Carboxypeptidase 0.905769590882004 2.443111064462939 0.0145612553269842 0.7517923382147271 0.1513077700152119 6 Q9HB40,P42785,Q9H3G5,P10619 4 +Protease 0.5049322592062279 2.4105810124618605 0.0159271336858117 0.7824347962940263 0.1513077700152119 81 Q9H3G5,P09960,Q96KP4,Q96K76,P42785,P10619,O95630,Q96FW1,Q9HB40,Q86UV5,O94966,O75844,P67812,Q9UIQ6,Q8TCT9,Q5JRX3,Q9NUQ7,Q9Y4E8,Q9H300,Q9NZ08,P28074,P42892,Q16740,O14773,P52888 25 +Host cell receptor for virus entry 0.7247930554511627 2.33520001536489 0.0195329743435321 0.8464908468393134 0.156323577308179 14 Q14108,Q8WTV0 2 +Porin 0.940392357563118 2.095861531619454 0.0360944760523147 0.9695719187285116 0.2236501819188795 4 P21796 1 +Guanine-nucleotide releasing factor 0.7079787547782423 2.079798966658332 0.0375439759362912 0.9736254513229284 0.2236501819188795 11 Q9Y4G8,P80303 2 +Glycosidase 0.6066834290308782 1.9180937946467176 0.0550991191652858 0.9954112529890332 0.3079068423942445 18 P10253,O60502,P04062,P16278,P04066,P54802,P08236,O43598 8 +Acyltransferase 0.5100509937261232 1.7906590473832216 0.073348025272983 0.9992804147054792 0.3484031200466693 36 Q9BWD1,O14929,Q09472,Q96N66,Q8NCC3,Q9NPF4,P23786 7 +Metalloprotease 0.5157707047449025 1.7568327540717048 0.0789463203847489 0.9995953593768832 0.3571381160262451 27 Q9NZ08,P09960,Q96KP4,Q9UIQ6,P42892,Q5JRX3,P52888,O75844 8 +Serine esterase 0.7433155437094455 1.6399175995809494 0.1010223009815203 0.999959621773596 0.4172660257932361 5 O00154 1 +Protease inhibitor 0.6650523469390164 1.4457301786023204 0.1482528963510927 0.9999997603854336 0.5416932751289927 7 P05067,P30086 2 +Heparin-binding 0.6243445435612129 1.3804452384657708 0.167449599543161 0.999999972521012 0.548541791606907 8 P10586,O14786,P35268,P05067 4 +Translocase 0.4675493606343016 1.2792957502771742 0.2007929285647818 0.999999999434236 0.6153331681823958 22 P08183,Q9HD20,P03886 3 +Chloride channel 0.7172246078830906 1.2233985431841674 0.2211792033392308 0.999999999951408 0.6566257599133415 4 Q4KMQ2 1 +Cytokine 0.6877547176502485 1.106731258264393 0.2684101365658538 0.9999999999998724 0.7385592034260463 4 P43490 1 +DNA-directed DNA polymerase 0.6801572317590572 1.076770305857618 0.2815828942713085 0.9999999999999774 0.7385592034260463 4 Q07864,P28340 2 +Monooxygenase 0.8261013580655895 1.0295996305404629 0.3031979887749032 0.9999999999999988 0.7385592034260463 2 Q16850 1 +Aminopeptidase 0.4833716555821417 1.001360643123895 0.316652484230205 0.9999999999999998 0.7520496500467369 13 Q9UIQ6 1 +Glycosyltransferase 0.3999220377631683 0.9381813592030056 0.3481512163066003 1.0 0.787484894026834 37 Q13126,P37287,P43490,P04062,Q9UGN5,P15291,Q16880,Q16739,Q2TAA5 9 +Serine protease 0.4716386314988398 0.8473823809578905 0.3967820218677003 1.0 0.8267279861498712 10 Q16740,O14773,Q9H300 3 +Serine protease inhibitor 0.780290789236519 0.8410670136913997 0.4003103932936218 1.0 0.8267279861498712 3 P30086 1 +Thiol protease 0.377936835116883 0.7574091625925741 0.4488047684427707 1.0 0.9003070480902458 27 Q96FW1,Q86UV5,Q96K76,Q9NUQ7,P51784,Q93009,O94966,Q9Y4E8,P55210 9 +GTPase activation 0.3609205262088869 0.6467257807469408 0.517809434639513 1.0 0.907849139450379 25 Q66K14,Q15042,Q9Y4G8 3 +Exonuclease 0.3838847774287638 0.584284583893212 0.5590288622400719 1.0 0.907849139450379 18 Q9UQ84 1 +Elongation factor 0.4055542318473339 0.5454035018711652 0.5854760324963595 1.0 0.907849139450379 11 P29692,Q05639 2 +Nucleotidyltransferase 0.3237678141026098 0.3152559127330633 0.752567356007444 1.0 0.9423331656307632 21 Q9Y5P6,O43252,P30876,P28340 4 +Aminotransferase 0.3459911965736598 0.1990292276726256 0.8422398815632062 1.0 1.0 8 Q6YP21,O15382,Q8TD30 3 +Thiol protease inhibitor 0.4609373137013221 0.0872124760709903 0.9305026226732324 1.0 1.0 3 P04080 1 +Actin capping 0.3100170791272109 0.0870823781804774 0.9306060323435068 1.0 1.0 7 P47755,P52907 2 +Tumor antigen 0.3667992047713675 0.0390720265373581 0.9688329635220452 1.0 1.0 3 Q96RS6,Q9UNF1 2 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b29f9398a12c17c09157181f95b0e60343fc36e1 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "ANKHD1", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APP", "APRT", "AQR", "ARFGAP1", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATG3", "ATG4B", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATRX", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BANF1", "BAP18", "BAZ1B", "BAZ2A", "BCAT2", "BCKDK", "BCLAF1", "BCOR", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BPHL", "BPNT1", "BPTF", "BRD2", "BRD4", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C12orf43", "CAD", "CADM1", "CALD1", "CALR", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX3", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC34", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CERS2", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHKA", "CHMP1A", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLIC4", "CLK2", "CLK3", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN3", "CNOT1", "CNOT2", "CNOT9", "CNP", "COASY", "COLGALT1", "COMT", "COMTD1", "COPA", "COPS5", "COQ3", "COQ8A", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCD", "DCP1A", "DCP2", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DRAP1", "DRG1", "DRG2", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "F11R", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM208A", "FAM213A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FNTB", "FOXC1", "FOXRED1", "FOXRED2", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL3", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HTATIP2", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INF2", "INTS11", "IQGAP1", "IQGAP2", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JMJD6", "KARS", "KAT7", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LACTB", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LEO1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRPAP1", "LRPPRC", "LRRC8A", "LRRC8C", "LRSAM1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MAN2A1", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP2K4", "MAP4K4", "MAPK1", "MAPK3", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST3", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMACHC", "MMS19", "MOGS", "MORC2", "MORC3", "MORF4L1", "MOV10", "MPG", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTERF3", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MVK", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP3", "NCEH1", "NCL", "NCOA5", "ND1", "NDUFAF1", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEDD4", "NEK9", "NELFA", "NELFCD", "NELFE", "NES", "NFS1", "NGDN", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATL1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDXK", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4K2A", "PI4KA", "PIGA", "PIGG", "PIGK", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PSAT1", "PSIP1", "PSMB5", "PSMB7", "PSMD10", "PSMD14", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PVR", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIOX2", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPAP1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RSF1", "RTCA", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC61A1", "SEC63", "SENP1", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A3", "SLC27A4", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAMBP", "STAT1", "STAU1", "STAU2", "STK26", "STK4", "STMN1", "STRBP", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TALDO1", "TAMM41", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TECR", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TLK2", "TMCO1", "TMOD1", "TMOD3", "TMTC3", "TMX3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM3", "TPMT", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSN", "TSNAX", "TST", "TTF2", "TTK", "TTYH3", "TUFM", "TWF2", "TWNK", "TXNDC12", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBLCP1", "UBP1", "UBR2", "UBR4", "UBR5", "UBTF", "UCHL5", "UCK2", "UFL1", "UFSP2", "UGCG", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UROD", "USP10", "USP11", "USP14", "USP15", "USP19", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WNK2", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF1", "ZADH2", "ZC3H13", "ZC3H14", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZMPSTE24", "ZNF148", "ZNF207", "ZNF281", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["ABCB1", "ACAT2", "ACOT7", "ALG11", "ANO6", "APP", "ATP13A1", "B4GALT1", "BCAT2", "CAPZA1", "CAPZA2", "CASP7", "CLPP", "CNDP2", "CPT2", "CPVL", "CSTB", "CTSA", "CYP51A1", "DNPH1", "ECE1", "EEF1A2", "EEF1D", "EP300", "ERAP1", "EXO1", "FUCA1", "GAA", "GBA", "GLB1", "GMPPB", "GPT2", "GUSB", "HAT1", "HM13", "KDELR1", "KYAT3", "LBR", "LNPEP", "LTA4H", "M6PR", "MAGED2", "MBOAT7", "MGEA5", "MTAP", "NAGLU", "NAMPT", "ND1", "NPC1", "NRP1", "NUCB2", "NUDCD1", "OSGEP", "OTUB1", "PAPSS1", "PARL", 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0000000000000000000000000000000000000000..1508730da070aa31be0526ddebfa807cb2cf5c33 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2eb92f51db67466258d4136896bd1c521e0fcc057f35a84087f0a9837a2bbc04 +size 82359 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6f762c80d98d599de81c015457330ffe3b23657c --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Metabolic proteins 135 861 2.924434551406078 0.0034508263796022 167.96116504854368 885.0898058252427 0.3517504365488901 0.4992811695371688 49.08590099318301 81.73901275864796 1.4937513760737942 0.4046478208580187 0.1027472000666855 0.0178176256963347 6.992154759945128e-05 9.528507504736733e-09 2.3421733506116742e-09 +Candidate cardiovascular disease genes 0 7 2.2713982017810084 0.0231228831768952 2.563106796116505 9.29368932038835 0.1164468151756199 0.468077533298839 1.894908368881901 1.612649926975264 1.0410221205625372 0.2788935851718957 0.1449957667029796 0.1604648724397155 0.3009165941166509 0.5985687060361295 0.8437295850039954 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c0708d7323ce0c42e11086b4bf4350d3688e5abc --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 487.85 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cf9b1adaa4bcbecb5ee0bb86b4da1b6b8c91bfa4 --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..37e0b8d0416d2dce3881eac6a23b083fc56c6314 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metabolic proteins 0.3173782328841446 2.924434551406078 0.0034508263796022 0.066800135733427 0.0345082637960225 861 Q9BWD1,P00374,P30519,Q15165,P35790,P09601,Q8NCC3,Q9NZ01,Q9NPH0,Q8WTV0,Q9HC38,P10619,P00846,Q13126,P16278,Q8NBX0,O15118,P03886,Q8N4Q0,Q9UHG3,Q70HW3,P78417,Q96G23,Q9Y5P4,O75844,O60502,Q8IV08,P50897,P67812,P07099,Q8TB61,Q9H2D1,Q15800,P23786,O60725,P49748,O14949,Q9H7B4,Q9UDW1,Q9UBE0,P10253,Q15648,Q86UE8,P04062,Q96N66,Q9Y6M7,O15382,O14773,P21281,Q9NRF8,Q9BTX1,Q02252,Q15392,Q8NCH0,Q16739,O43772,Q9Y223,Q7LGA3,P08183,O00443,P43490,Q9H2H8,Q9UBX3,P11802,Q96K76,Q9Y6M9,Q6UX04,Q16850,P08236,Q9BRR6,O75964,P30876,Q86YN1,Q86Y39,P16435,P00403,O43865,P49366,Q14527,Q99873,Q93050,P49356,P54802,Q13356,Q16775,Q9Y4E8,Q96T60,P07602,Q14534,P00390,Q96AY3,P22830,O95470,P10586,Q8TBX8,P52888,P48507,P15586,O00764,P83881,O14929,Q7L2J0,Q96KP4,Q9Y5P6,Q8IV63,Q9NRN7,Q15102,Q9Y487,P53985,Q14739,O95864,Q9Y680,Q09472,P04066,Q9BSD7,Q9BQT8,O14579,P43034,O43252,Q2TAA5,Q9Y217,Q99808,Q96KB5,P35270,O15514,Q9UBQ0,Q9BTY2,Q99943,Q96IX5,O75414,O00154,Q13510,Q05639,P30085,P53701 135 +Enzymes 0.2736607332674844 1.6632001690994496 0.0962723738158572 0.867946118851861 0.2750639251881637 890 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169 +FDA approved drug targets 0.4467026613670707 1.4393732134833193 0.150044809505601 0.9612813142305936 0.3353436970115043 117 P00374,P11802,P39023,Q16850,P68371,Q99720,P20618,P03886,P07437,P05067,P49721,P49356,P23786,Q13509,P10253,Q14534,P20645,P00390,P21281,Q16739,O00764 21 +Predicted secreted proteins 0.4435726794076103 1.4363433527136782 0.1509046636551769 0.9620572232495098 0.3353436970115043 46 Q9NZ08,P43490,Q15165,Q9HB40,Q02818,P80303,O60888 7 +Predicted membrane proteins 0.4848938665342591 0.8741392870108847 0.3820424045856021 0.9999340562725662 0.6946225537920038 518 P30519,P24390,Q99595,P09601,Q8NCC3,Q9NZ01,Q14108,Q8WTV0,Q13641,P00846,Q99720,Q9NS69,Q5VW38,O60830,O00461,Q96KA5,Q9Y282,Q9UDX5,Q8NBX0,O15118,P03886,Q9NR77,Q9HD20,Q70HW3,O43657,Q96G23,O75844,O43169,Q8IXU6,Q15629,Q8IV08,P67812,Q9UIQ6,Q8TB61,Q9GZP9,Q15800,O60725,Q9H6K4,Q9UDW1,Q96CP7,O15260,Q96N66,Q9Y6M7,P42892,Q567V2,Q9BTX1,Q02252,Q15392,Q8NCH0,Q16739,O43772,Q9Y223,P08183,Q9H2H8,Q9UBX3,Q86XL3,Q9GZM5,Q16850,O75964,O15173,P42858,Q7Z3C6,Q96ES6,Q8N4V1,Q9BY67,Q86YN1,Q86Y39,P16435,P00403,P05067,Q9HD45,Q9NQC3,Q6ZXV5,Q96A26,Q8NC54,Q8IXM6,O14925,O95070,P43307,O75880,Q9H1E5,Q93050,Q13505,Q969V3,Q9NPR9,Q52LJ0,Q4KMQ2,Q14534,P20645,O95197,Q9NZJ7,Q96GC9,O43760,O95470,P10586,Q15631,Q14728,O14548,Q9C0H2,Q9Y487,Q8TAA9,P53985,Q14739,P49257,O95864,Q8IZA0,Q9H4I3,Q9BSK2,Q3SXM5,O96005,Q6PK18,Q8IWB1,Q9NX00,Q96NB2,Q2TAA5,Q99805,P35613,O94822,Q99808,Q99943,Q96IX5,Q5VW36,P57088,O75915,O60831,A1L0T0,Q9NPL8,Q6NUM9,Q16880,Q8WUK0,P37287,Q9Y2R0,Q9BUN8,P11117,P38435,Q8N2K0,P15291,Q16625,Q9Y6C9,Q9UBU6,Q96SK2,P04920,O94966,Q6PIU2,Q9Y262,P51648,P48651,P35573,Q9Y4R8 149 +Human disease related genes 0.2449265664084905 0.4723276670012272 0.6366929251965379 0.9999999983949924 0.9795275772254428 873 P00374,Q9BVA1,P09601,Q9NZ01,Q14108,Q9Y4G8,P10619,P00846,P68371,Q99720,Q13885,Q96CU9,P04350,P16278,O15118,P03886,Q9NR77,P07437,Q70HW3,Q9Y5P4,O75844,Q8IV08,P50897,P07099,Q15800,P23786,Q9H6K4,P49748,O14949,Q13509,Q9BPX6,P10253,Q86UE8,P04062,Q96N66,P62304,P42892,O14773,Q9NPF4,P21281,Q02252,Q15392,Q8NCH0,O43772,Q9Y223,P08183,Q9UBX3,P11802,Q9Y6M9,Q86XL3,Q6UX04,P49711,O75503,P08236,Q96AX1,P42858,Q8NC96,Q9Y3Z3,Q9BY67,Q2M389,Q86Y39,P16435,P00403,P05067,Q6ZXV5,P49366,O75880,P54802,P61313,Q9NUQ7,Q9Y6X9,Q4KMQ2,Q96T60,P07602,O75879,Q96AY3,P22830,O95470,P50542,P15586,Q9Y5P6,Q15042,Q9Y487,Q8TAA9,P53985,Q14739,P49257,Q09472,P27635,Q12955,P04066,Q9BQT8,P43034,Q2TAA5,Q8IWS0,Q12948,Q9BW83,Q08J23,P35270,Q96IX5,Q96F86,O75718,O00170,Q13510,Q15436,Q15233,Q05639 107 +Disease related genes 0.2354948907728422 0.1716346906273012 0.8637247329605038 1.0 1.0 971 P00374,Q9BVA1,P09601,Q9NZ01,Q14108,Q9Y4G8,P10619,P00846,P68371,Q99720,Q13885,Q96CU9,Q13126,P04350,P16278,O15118,P03886,P07437,Q70HW3,Q9Y5P4,O75844,Q8IV08,P50897,P07099,Q9H2D1,Q9BUF5,Q15800,P23786,Q9H6K4,P49748,O14949,Q13509,Q9BPX6,P10253,Q86UE8,P04062,Q96N66,P62304,P42892,O14773,Q9NPF4,P21281,Q02252,Q15392,Q8NCH0,O43772,Q9Y223,P08183,O00443,P11802,Q9Y6M9,Q86XL3,Q6UX04,P49711,O75503,P08236,Q96AX1,P42858,Q8NC96,Q9Y3Z3,P28070,Q2M389,Q86Y39,P16435,P00403,P05067,Q01844,Q6ZXV5,P62266,P49366,O75880,P54802,P61313,Q9NUQ7,Q9Y6X9,Q4KMQ2,Q6DKJ4,Q9H6R7,Q96T60,P07602,P00390,O75879,Q96AY3,P22830,O95470,P10586,P50542,P15586,O00764,Q9Y5P6,Q15042,Q9Y487,Q8TAA9,P53985,Q14739,P49257,Q09472,P27635,Q12955,P04066,Q9BQT8,P43034,Q2TAA5,Q8IWS0,Q12948,Q9BW83,Q08J23,P35270,Q96IX5,Q96F86,O75718,O00170,Q13510,Q15436,Q15233,Q05639,P53701 117 +CD markers 0.3030617338873513 0.159999715108889 0.8728812986363297 1.0 1.0 17 P08183,O14786,P35613,P02786 4 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..55d04fb80dd0a4a11a474a538688651ca1242a43 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD11", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATL2", "ATM", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "B4GAT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD2", "BRD4", "BRIX1", "BROX", "BSDC1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf57", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C2orf49", "C3orf58", "C5orf15", "C5orf51", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASK", "CASP7", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC134", "CCDC138", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC97", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC16", "CDC23", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKAL1", "CDKN2AIP", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLN5", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COA7", "COASY", "COG1", "COG3", "COG8", "COIL", "COL4A3BP", "COLGALT1", "COMMD2", "COMMD8", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COQ3", "COQ8A", "COQ9", "CORO1B", "CORO1C", "COTL1", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPNE8", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERG28", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM129B", "FAM162A", "FAM208A", "FAM210B", "FAM213A", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FOXRED2", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA11", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPAT4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF15", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LENG8", "LEO1", "LETM1", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LONP2", "LPCAT1", "LPGAT1", "LRBA", "LRCH2", "LRIG2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRSAM1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMGT1", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL24", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NEK9", "NELFA", "NELFCD", "NELFE", "NEMF", "NENF", "NEO1", "NES", "NFATC2IP", "NFS1", "NFU1", "NGDN", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIPSNAP3A", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4K2A", "PI4KA", "PICALM", "PIGA", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "PON2", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11FIP1", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB31", "RAB35", "RAB39A", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB8B", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF2L1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIGMAR1", "SIMC1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFIP11", "TFRC", "TGFBRAP1", "THNSL1", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM14C", "TMEM160", "TMEM167A", "TMEM192", "TMEM201", "TMEM209", "TMEM214", "TMEM230", "TMEM30A", "TMEM33", "TMEM43", "TMEM70", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPMT", "TPP1", "TPP2", "TPR", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", 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0000000000000000000000000000000000000000..bd3d3278a9e65741bbd8978ab093eb326c4426b2 --- /dev/null +++ b/protein_atlas_subcellular_location_all/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c9cdfcf82087d220624950be5bc8895b241ee426a26e2298415e8c7803605340 +size 69664 diff --git a/protein_atlas_subcellular_location_all/df_merge.tsv b/protein_atlas_subcellular_location_all/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ed162266b76a585ed949bb4a241663c80ff6fd90 --- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitotic spindle 6 24 3.455149333882852 0.0005499881070771 8.230582524271844 22.633495145631063 -0.213814458319639 0.5636457653325838 4.148076715462782 3.2915225646599717 0.9898553726584056 0.3255608820421566 0.0001054611075806 0.0001627366612638 1.3843081040417905e-06 0.0005369188903581 0.0075623716640415 +Cytokinetic bridge 6 29 3.105052237564355 0.0019024542253542 8.053398058252426 26.512135922330096 -0.2163554342259742 0.6149631031992273 4.040097940127376 4.147446085251598 0.8071519689625233 0.3008673491956053 0.0009286672568181 0.0014082531077113 6.06333354071757e-05 0.0133289547851377 0.245303057068218 +Microtubules 8 51 2.9643139775510385 0.0030335859213908 11.762135922330096 51.536407766990294 0.1467824701124027 0.6383504938877967 6.107191630577272 6.9907105288235005 0.8576674618245522 0.3225755572425843 0.0007985422527838 0.0013257406773376 4.465714214249106e-05 0.0104070887772844 0.2363085844338239 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..91b92f3782fa6349fe4cc98c85301e611711a629 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3021, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 141.3030303030303 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8b1edf48dc619640c3344a54236aef1342dd63cf --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C255/C255_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..583bc2bf31465e788141af1836b5e133031b664a --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitotic spindle 0.7858504295923814 3.455149333882852 0.0005499881070771 0.0179907983917985 0.018149607533547 24 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Cytokinetic bridge 0.7158725067781394 3.105052237564355 0.0019024542253542 0.0609070198349338 0.0313904947183457 29 Q9BVA1,P04350,Q9BUF5,P07437,P68371,Q13885 6 +Microtubules 0.6046418125500918 2.9643139775510385 0.0030335859213908 0.0953982494828226 0.0333694451352988 51 O60830,Q9BVA1,P04350,Q02818,Q9BUF5,P07437,P68371,Q13885 8 +Lysosomes 0.5853198285944153 1.5071106725840373 0.1317822916092939 0.9905649304484434 0.5436019528883372 12 O60749,Q8WTV0,Q9UNH7,P02786 4 +Rods & Rings 0.7202382525330498 1.235355909564598 0.2166980742955107 0.9996840172243564 0.6889488555240524 4 Q8WTV0 1 +Golgi apparatus 0.4420759347996367 1.003294615182008 0.3157187334815767 0.9999963462109694 0.7486340911903655 160 P24390,Q13362,P09601,Q9GZM5,Q5VW38,O00461,Q9HB40,P16278,P80303,Q8N4Q0,P05067,Q9HD45,Q8NC54,Q9Y5P4,O95070,Q8IXU6,P50897,P67812,Q93050,Q02818,Q9NPR9,O15260,O43760,P10586,Q8NCH0 25 +Nuclear membrane 0.3144672230134254 0.6222788992183887 0.533758493532726 0.999999999988408 0.9230289282648524 63 Q14728,Q9H1E5,P67812,P11802,Q9BTX1,O00560,Q8IXM6,Q96G23,O15260 9 +Endosomes 0.4206937979118682 0.598216979617275 0.5496951632396372 0.999999999996321 0.9230289282648524 10 O60749,Q9UNH7,P02786 3 +Focal adhesion sites 0.3499293184163359 0.5547432985117231 0.5790702556292473 0.9999999999996028 0.9230289282648524 28 P08183,P50552,Q9Y6M7,O60888,Q9Y487,Q96AC1 6 +Centriolar satellite 0.3466843918331015 0.5424991676639377 0.5874746806884106 0.999999999999796 0.9230289282648524 26 Q13045,Q5SVZ6,Q9Y6A5,O43169 4 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bb55c1abd3b75d87b52c223d943c5fd59ebb4896 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALG1", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1S2", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APMAP", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF6", "ARFGAP1", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGAP5", "ARHGDIA", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC5", "ARVCF", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD2B", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG9A", "ATIC", "ATL2", "ATM", "ATP13A1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "B4GALT1", "BABAM1", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDK", "BCL2L13", "BCLAF1", "BCOR", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOD1L1", "BOP1", "BPHL", "BPNT1", "BPTF", "BRAT1", "BRD2", "BRD4", "BRIX1", "BROX", "BSDC1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf57", "C16orf58", "C17orf75", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C2orf49", "C5orf15", "C5orf51", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2G", "CAMSAP3", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC138", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC97", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC27", "CDC34", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK6", "CDK9", "CDKN2AIP", "CDV3", "CEBPZ", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLK2", "CLK3", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN3", "CNNM3", "CNOT1", "CNOT11", "CNOT2", "CNOT9", "CNP", "COA3", "COA7", "COG3", "COG8", "COIL", "COL4A3BP", "COLGALT1", "COMMD8", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS4", "COPS5", "COPS6", "COPS8", "COQ3", "COQ8A", "COQ9", "CORO1B", "COTL1", "COX14", "COX4I1", "COX5B", "COX6C", "COX7A2L", "CPD", "CPNE1", "CPNE2", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF4", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWC27", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCP1A", "DCP2", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR7", "DHFR", "DHODH", "DHPS", "DHRS1", "DHRS4", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOLPP1", "DPF2", "DPH2", "DPH5", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRAP1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DTYMK", "DUSP11", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELL", "ELMOD2", "ELOA", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENSA", "EP300", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EXT2", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM129B", "FAM162A", "FAM208A", "FAM210B", "FAM49B", "FAM50A", "FAM8A1", "FAM98A", "FAM98B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP14", "FKBP15", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GHITM", "GID8", "GIGYF2", "GINS3", "GINS4", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNE", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOLT1B", "GOT1", "GPAA1", "GPD2", "GPHN", "GPI", "GPKOW", "GPN1", "GPR107", "GPR108", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2H1", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTF3C6", "GTPBP1", "GTPBP3", "GTPBP4", "GTPBP8", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDGFL3", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HGH1", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN1", "HMGN2", "HMGN5", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPBP1", "HSPD1", "HSPH1", "HTATIP2", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INTS1", "INTS11", "INTS12", "INTS13", "INTS14", "INTS3", "INTS4", "INTS7", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ISOC2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIDINS220", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KMT2A", "KNL1", "KNOP1", "KNTC1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LENG8", "LEO1", "LETM1", "LGMN", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRIG2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8C", "LRSAM1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZIC", "LZTFL1", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN2A1", "MAN2B1", "MANF", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED1", "MED12", "MED17", "MED21", "MED23", "MED4", "MEPCE", "MESD", "METAP1", "METAP2", "METTL13", "METTL16", "METTL7B", "MFGE8", "MFN1", "MFN2", "MFSD10", "MFSD3", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MIPEP", "MKI67", "MMAB", "MMACHC", "MMS19", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP5", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL20", "MRPL21", "MRPL22", "MRPL23", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTA3", "MTAP", "MTBP", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVK", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCEH1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF1", "NDUFAF4", "NDUFB4", "NDUFB6", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEFL", "NELFA", "NELFCD", "NELFE", "NEMF", "NEO1", "NES", "NFATC2IP", "NFS1", "NFU1", "NGDN", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME6", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NRM", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NT5DC1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCIAD2", "OCLN", "OCRL", "OGDH", "OGFOD3", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PATJ", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCDH7", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGLUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POM121", "POM121C", "POP1", "POP4", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIL1", "PPIL2", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5C", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPT1", "PPT2", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCSH", "PRKDC", "PRKG1", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPMT1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PVR", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QPCTL", "QRSL1", "QSOX2", "QTRT2", "RAB11FIP1", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBFOX2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM7", "RBMX", "RBPMS", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REEP6", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RHOA", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RMDN1", "RMDN3", "RNASEH2A", "RNF20", "RNF40", "RNMT", "RNPEP", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS21", "RPS23", "RPS24", "RPS25", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTFDC1", "RTKN", "RTN1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD2", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC62", "SEC63", "SENP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SIMC1", "SIN3A", "SINHCAF", "SIRT2", "SKA1", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A3", "SLC27A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A11", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPATA5", "SPATA5L1", "SPCS2", "SPECC1L", "SPEN", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SRBD1", "SRC", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRIP1", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX7", "STX8", "STXBP2", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF9B", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TECR", "TEFM", "TELO2", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFCP2", "TFIP11", "TFRC", "TGFBRAP1", "THNSL1", "THOC1", "THOC2", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMEM167A", "TMEM192", "TMEM201", "TMEM209", "TMEM214", "TMEM230", "TMEM70", "TMOD3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPR", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC4", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSR1", "TSR2", "TST", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTF2", "TTI1", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TXLNA", "TXLNG", "TXN2", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBLCP1", "UBN2", "UBP1", "UBQLN4", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UGT8", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VMP1", "VPS13C", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS36", "VPS37C", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR62", "WDR70", "WDR77", "WDR82", "WIPI2", "WIZ", "WNK2", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H13", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF148", "ZNF207", "ZNF281", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "APP", "ATP6V0A1", "ATP6V0A2", "C5orf15", "CDK4", "CERS2", "CHST14", "COL4A3BP", "CUTA", "CYB5B", "FERMT2", "FLII", "GLB1", "GOLIM4", "GPR107", "GPR108", "HMOX1", "KDELR1", "MFSD10", "NDC1", "NRM", "NUCB1", "NUCB2", "PPP2R5C", "PPT1", "PTPRF", "SCARB1", "SCPEP1", "SDCBP", "SEC11A", "SLC35F2", "SLC4A7", "SNX2", "SNX6", "SURF4", "SYNGR2", "TACC3", "TFRC", "TIMM17B", "TM9SF3", "TMX4", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "VASP", "YIF1A", "YIPF3", "ZADH2", "ZMYM1"]} \ No newline at end of file