Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Signaling by hedgehog 0.6634082993758752 3.53164745242682 0.000412979543525 0.4330879457158888 0.1837002421863482 53 P60900,P49720,P28070,Q9BVA1,P04350,Q9GZP9,Q9BUF5,P49721,Q13509,P68371,Q13885 11 The role of gtse1 in g2 m progression after g2 checkpoint 0.6935248851027539 3.4614106642601636 0.0005373524311489 0.5221797585419129 0.1837002421863482 47 P60900,P49720,P28070,Q9BVA1,P04350,Q9BUF5,P49721,Q13509,P68371,Q13885 10 Hedgehog off state 0.6759258682444527 3.333338182480221 0.0008581057090397 0.6925809268421654 0.1837002421863482 47 P60900,P49720,P28070,Q9BVA1,P04350,Q9BUF5,P49721,Q13509,P68371,Q13885 10 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.8665761004396154 3.306042343529889 0.0009462378702014 0.7276715320457454 0.1837002421863482 18 Q9BVA1,P04350,Q9BUF5,P78371,P68371,Q13885 6 Cilium assembly 0.6173655592829521 3.2758692476352635 0.0010533731598747 0.7649830287085787 0.1837002421863482 55 Q9H6D7,Q9BVA1,P04350,Q9BUF5,P78371,A6NIH7,P07437,Q13509,P68371,Q13885 10 Translocation of slc2a4 glut4 to the plasma membrane 0.7265295454365062 3.2656218159565533 0.0010922401495878 0.777217238485693 0.1837002421863482 34 Q9BVA1,P04350,Q9UIQ6,Q9BUF5,P68371,Q13885 6 Protein folding 0.7187730726193187 3.263071338191292 0.0011021177336763 0.7802236528373011 0.1837002421863482 36 Q9BVA1,P04350,Q9BUF5,P78371,Q13509,P68371,Q13885 7 Formation of tubulin folding intermediates by cct tric 0.9165741858477364 3.2494384831352803 0.0011563308545581 0.7960168509658934 0.1837002421863482 14 Q9BVA1,P04350,Q9BUF5,P78371,P68371,Q13885 6 Copi dependent golgi to er retrograde traffic 0.6587847311605374 3.2068672296005936 0.00134188912456 0.8419737029463283 0.1837002421863482 47 P24390,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 7 Selective autophagy 0.7098274877176493 3.1807397075556483 0.0014689955258131 0.8673291215968391 0.1837002421863482 35 P21796,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885,Q9NS69 8 Kinesins 0.7906994915916402 3.1705985069449136 0.001521252434784 0.8765343527078014 0.1837002421863482 21 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Autophagy 0.6286094624636198 3.155111292601825 0.0016043689273916 0.8898787379016961 0.1837002421863482 51 P21796,Q9BVA1,P04350,Q9BUF5,P50542,Q8N4H5,Q8WUX9,Q13509,P68371,Q13885,Q9NS69,Q7Z3C6 12 Post chaperonin tubulin folding pathway 0.932189373169196 3.106074873647208 0.0018958870389453 0.9262755851578344 0.2003806762700741 11 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Gap junction trafficking and regulation 0.9022109587712692 3.041898119625319 0.0023509144965288 0.9605988151361424 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Recruitment of numa to mitotic centrosomes 0.6903497459260038 2.9928969652230246 0.002763430263841 0.9776785945545412 0.2280545450772817 32 Q9H6D7,Q9BVA1,P04350,Q9BUF5,P07437,Q13509,P68371,Q13885 8 Copi independent golgi to er retrograde traffic 0.6921850374241817 2.9566316928988567 0.003110193828621 0.9861582472503764 0.2280545450772817 29 Q9UJW0,Q9BVA1,P04350,Q15042,Q9BUF5,Q15102,P43034,Q13509,P68371,Q13885 10 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.6831861480184835 2.9295257628884888 0.0033947967027936 0.9906500666586512 0.2280545450772817 31 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Aggrephagy 0.8183894586147685 2.927426864343867 0.0034177943349711 0.9909418721028296 0.2280545450772817 16 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Rho gtpases activate iqgaps 0.8753744083305596 2.922255911809014 0.0034750588234724 0.9916295390880596 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Cytoprotection by hmox1 0.5376169382760355 2.8850443951785674 0.0039135846899411 0.9954280482638612 0.2280545450772817 60 P30519,Q15648,P60900,P49720,P28070,P09601,P20618,P00403,P49721 9 Copi mediated anterograde transport 0.5908708643108576 2.852917330547697 0.0043319889455293 0.997433167153744 0.2280545450772817 51 P24390,Q9BVA1,P04350,Q9BUF5,P68371,Q13885 6 Intraflagellar transport 0.8594630941069132 2.8504593132467746 0.004365613535004 0.997549552148299 0.2280545450772817 12 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Sealing of the nuclear envelope ne by escrt iii 0.9221199491708488 2.844738283540594 0.0044447926821431 0.9978032098237276 0.2280545450772817 9 Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 6 Mhc class ii antigen presentation 0.5892759970822654 2.839931037581857 0.0045123287595798 0.9979987234378228 0.2280545450772817 51 Q9BVA1,P04350,Q9BUF5,P10619,P68371,Q13885 6 Factors involved in megakaryocyte development and platelet production 0.6096952722652663 2.834816021077733 0.0045852083013957 0.9981902455223028 0.2280545450772817 47 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Assembly and cell surface presentation of nmda receptors 0.8664081339456998 2.818226587417104 0.0048289718504537 0.9987073736701634 0.2280545450772817 11 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Recycling pathway of l1 0.722013310281106 2.7903188452437715 0.0052656157850432 0.999292711186982 0.2280545450772817 21 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Golgi to er retrograde transport 0.5300731984112135 2.777535089416958 0.0054772925673582 0.999472037902612 0.2280545450772817 70 P24390,Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 7 Mitotic g2 g2 m phases 0.539257445879825 2.7330194054706403 0.006275663473781 0.9998248612643522 0.2463646175135763 82 Q9H6D7,P60900,P49720,P28070,Q9BVA1,P04350,Q7Z460,Q9BUF5,P07437,P49721,Q13509,P68371,Q13885 13 Transport of connexons to the plasma membrane 0.9718076285240488 2.7034421186753583 0.0068625398943682 0.999922220487006 0.2472626029471571 6 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Gap junction assembly 0.9718076285240488 2.7034421186753583 0.0068625398943682 0.999922220487006 0.2472626029471571 6 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Activation of ampk downstream of nmdars 0.9260617457749049 2.70066378079757 0.0069201255639397 0.9999281768884029 0.2472626029471571 8 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Activation of nmda receptors and postsynaptic events 0.6576062235286207 2.687526962713461 0.0071983290523189 0.9999511264117824 0.2472626029471571 24 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Glycerophospholipid biosynthesis 0.6515629734960243 2.673886685020583 0.0074977781232909 0.9999677102959158 0.2512670034488252 27 Q9NPH0,P35790,Q8IV08,Q8NCC3 4 Carboxyterminal post translational modifications of tubulin 0.9553539018080685 2.664662641153856 0.0077065590626608 0.9999758161294028 0.2521145750499041 7 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Protein localization 0.5131278893749105 2.6258165687083084 0.0086441386466169 0.999993401562452 0.2608713874371463 69 P46379,P21796,O60830,Q99595,Q13505,P09601,Q9NR77,Q5JRX3,P50542,Q8N4H5,P05067,Q9Y512,O14925,Q9NS69 14 Er to golgi anterograde transport 0.5095383027643514 2.6024684573493357 0.0092555328837578 0.99999717307112 0.2608713874371463 68 P63167,Q9UJW0,Q15436,Q13509,P24390,Q9BVA1,Q12955,P04350,Q9BUF5,O14579,P49257,P68371,Q13885 13 Pink1 prkn mediated mitophagy 0.8615406669096244 2.5885011818821693 0.0096394616218531 0.9999983402921884 0.2608713874371463 9 P21796,Q9NS69 2 Ub specific processing proteases 0.5031555072800776 2.586948757500536 0.0096829990970119 0.9999984375775004 0.2608713874371463 64 Q96FW1,P21796,P45880,P49720,P60900,P28070,Q96K76,P20618,P49721 9 Sphingolipid metabolism 0.6280453307271844 2.5214870288266966 0.0116859983838193 0.9999999032482708 0.2936880061970757 27 Q16739,P07602,P51648,P04062,Q9NZJ7,P16278,P22059,O95470,P10619,Q16880,O43681,O15269,Q96G23,Q9Y5P4,Q13510,P06280 16 Nuclear envelope ne reassembly 0.5731417904845637 2.5130329090115797 0.0119698168464601 0.9999999347964486 0.2936880061970757 46 Q9BVA1,P04350,Q86XL3,Q9BUF5,Q9BTX1,Q13509,P68371,Q13885 8 Mitochondrial protein import 0.6122182238837408 2.487741665066177 0.0128557077825284 0.999999980989322 0.3045472843654148 33 O60830,P21796,Q99595,Q13505,Q5JRX3,Q8N4H5,Q9Y512,O14925,Q9NS69 9 Phospholipid metabolism 0.5869616754026117 2.470469160162239 0.0134935953203727 0.9999999921787676 0.3046382295531648 41 O00443,Q9Y217,Q8IV08,Q96N66,P35790,P48739,Q8NCC3,Q99943,Q9NPH0,Q8TBX8,Q8WUK0 11 Transport to the golgi and subsequent modification 0.4978168419814317 2.453107594566054 0.0141627969214002 0.9999999969214276 0.3046382295531648 71 P63167,Q9UJW0,Q15436,Q13509,P24390,Q9BVA1,Q12955,P04350,P04066,Q9BUF5,O14579,P49257,P68371,Q13885 14 Rho gtpases activate formins 0.515487994429746 2.4468379699546725 0.0144115610778425 0.9999999978235178 0.3046382295531648 56 P63167,Q9BVA1,Q13362,P04350,Q7Z460,P49454,Q9BUF5,P43034,Q13509,P68371,Q13257,Q13885,Q9P258 13 Resolution of sister chromatid cohesion 0.4924082805941587 2.3951084108176905 0.0166154517355046 0.999999999899556 0.3170782039525462 59 Q9BVA1,Q13362,P04350,Q9BUF5,P68371,Q13885 6 Mitophagy 0.7400413805736776 2.349161837448539 0.0188157266602675 0.999999999995373 0.3244353517787946 13 P21796,Q9NS69 2 Hcmv infection 0.5242487057843181 2.336511462128338 0.0194646009232355 0.9999999999981356 0.3244353517787946 52 Q9BVA1,P04350,Q9BUF5,Q9BTX1,Q13509,P68371,Q13885 7 Sialic acid metabolism 0.9099268853142212 2.319262182781068 0.0203808246208332 0.999999999999484 0.3248972990527297 5 P16278,P10619 2 Mitochondrial calcium ion transport 0.6878727663031046 2.315746759216845 0.0205720997216793 0.9999999999996054 0.3248972990527297 17 P21796,P45880 2 Heparan sulfate heparin hs gag metabolism 0.9049229813905162 2.2995253841716243 0.0214751236448429 0.9999999999998888 0.3303012094786078 5 P16278,P08236,Q7LGA3 3 Hcmv early events 0.5566714148646486 2.2921354734412605 0.0218978269896692 0.9999999999999386 0.330633123997863 43 Q9BVA1,P04350,Q9BUF5,Q13509,P68371,Q13885 6 Neurotransmitter receptors and postsynaptic signal transmission 0.5798181310737225 2.2757910352383277 0.0228585195613091 0.999999999999984 0.3316390147475289 34 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Gpcr ligand binding 0.7811822980068276 2.235674138272193 0.0253731242834307 0.9999999999999996 0.3367439920860747 9 P07602,P05067,P42892 3 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.8137767428191075 2.230729520738028 0.0256990509479615 0.9999999999999996 0.3367439920860747 8 P46379,O43681,P05067,P09601 4 Intra golgi and retrograde golgi to er traffic 0.4927156306615816 2.2235000623397516 0.0261820991886201 1.0 0.3367439920860747 87 Q9UJW0,P63167,O00461,P20645,P24390,Q9BVA1,P04350,Q15042,Q9BUF5,Q15102,O14579,P43034,Q13509,P68371,Q13885,O15260 16 Metabolism of porphyrins 0.8093785950522181 2.2117799415637474 0.0269818737182285 1.0 0.3432693934152413 8 P30519 1 Glycosphingolipid metabolism 0.6651310869869741 2.1917732722315697 0.0283958819504974 1.0 0.3535465647006514 17 P07602,P04062,O43681,Q9NZJ7,P16278,P10619,Q16739,Q13510 8 Eukaryotic translation elongation 0.4737041400479234 2.189484801336031 0.0285616220391355 1.0 0.3535465647006514 73 Q9Y3U8,P15880,P26641,P50914,P39023,P32969,P46776,P62829,P84098,P29692,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,P36578,P46781,P47914,Q05639,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 45 Cholesterol biosynthesis 0.6810845430270616 2.1736063614136096 0.0297347102694958 1.0 0.3583815079849758 15 Q9BWD1,Q14534,Q15800,Q16850,Q15392 5 Biological oxidations 0.5439184317353605 2.1665179974373685 0.0302716260899755 1.0 0.3616801238924038 42 P78417,Q96KP4,P07099,Q8TB61,P16435,Q9NUJ1,Q16850,Q86WA6,O43252,P48507,O43169 11 Peptide ligand binding receptors 0.8277049269937852 2.147728098942866 0.0317353618037352 1.0 0.3664564713201577 7 P07602,P05067,P42892 3 Class a 1 rhodopsin like receptors 0.8277049269937852 2.147728098942866 0.0317353618037352 1.0 0.3664564713201577 7 P07602,P05067,P42892 3 Diseases of carbohydrate metabolism 0.7313254661598051 2.141029740929137 0.0322716397596354 1.0 0.3664564713201577 10 P10253,P16278,P54802,O43826,P08236 5 Deubiquitination 0.4773624469304974 2.1352651052148586 0.0327393615400697 1.0 0.3687203504594739 81 P21796,P45880,P49720,Q8NB78,Q96K76,O95630,Q96FW1,P60900,P28070,Q09472,Q86UV5,P20618,P49721,Q15018,O94966,Q9Y4E8,P28074,P25788,P51784,Q9Y277 20 Transmission across chemical synapses 0.5394022154927269 2.1074891757320855 0.0350751989765252 1.0 0.3771029256976376 41 Q9BVA1,P04350,Q9BUF5,P68371,Q13885 5 Iron uptake and transport 0.6494705559831675 2.105374617908488 0.0352587114466915 1.0 0.3771029256976376 17 Q93050,P30519,P09601,P21281 4 Glycosaminoglycan metabolism 0.6573823654809902 2.096186072014973 0.0360656879903189 1.0 0.3773444317699077 16 P16278,Q8TB61,P54802,P08236,Q8NCH0,P15586,Q7LGA3 7 Response of eif2ak4 gcn2 to amino acid deficiency 0.4615387953246541 2.07770341011141 0.0377366847775608 1.0 0.380281670235748 72 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P05198,P62280,P46778,P18077,P62249,P08243,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,P46783,Q07020,P83881 44 Synthesis of substrates in n glycan biosythesis 0.6612087832699086 2.068436167178696 0.0385990272307548 1.0 0.380281670235748 15 P16278,Q86YN1,Q9Y223,P10619 4 Organelle biogenesis and maintenance 0.4783731015793028 2.068071980212306 0.0386332550447579 1.0 0.380281670235748 88 Q9H6D7,Q15648,Q9BVA1,O75964,P04350,Q7Z460,Q9BUF5,P78371,A6NIH7,P07437,Q9Y512,P00846,Q13509,P68371,Q13885 15 Recruitment of mitotic centrosome proteins and complexes 0.560221349786203 2.0668555374252433 0.0387477684374124 1.0 0.380281670235748 27 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 Cellular response to chemical stress 0.4561789637175083 2.0346690360815183 0.0418841857990228 1.0 0.3999391903368412 71 P30519,Q15648,P60900,P49720,P28070,O75880,P00390,P09601,P20618,P00403,P49721 11 Neuronal system 0.4943716147659115 2.034362852970524 0.0419150243147781 1.0 0.3999391903368412 51 O95197,Q9BVA1,P04350,Q9BUF5,Q15334,P10586,Q14168,Q13509,P68371,Q13885 10 Nr1h2 and nr1h3 mediated signaling 0.834983514660232 2.0191756663077083 0.0434689645426074 1.0 0.4056461449435031 5 Q8NB78,Q9HCE1 2 Phase ii conjugation of compounds 0.5535738876739282 2.016317391523435 0.04376679746462 1.0 0.4056461449435031 26 Q96KP4,Q8TB61,Q9NUJ1,P78417,P48507 5 Aurka activation by tpx2 0.5515848058548619 2.013125388652334 0.0441014399199228 1.0 0.4056461449435031 28 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 Mucopolysaccharidoses 0.9171362280410984 2.007339960690262 0.0447134769578008 1.0 0.4068630287418431 4 P16278,P54802,P08236 3 Inflammasomes 0.91088636572468 1.9834278694487464 0.0473196566628784 1.0 0.4194658597083563 4 P09601 1 Purinergic signaling in leishmaniasis infection 0.91088636572468 1.9834278694487464 0.0473196566628784 1.0 0.4194658597083563 4 P09601 1 The nlrp3 inflammasome 0.91088636572468 1.983427869448744 0.0473196566628786 1.0 0.4194658597083563 4 P09601 1 Transport of inorganic cations anions and amino acids oligopeptides 0.6846372994662671 1.9654271763815003 0.0493648166433653 1.0 0.4251297349602327 11 Q9Y6M7,Q70HW3 2 Mapk family signaling cascades 0.4597809076228659 1.9561611702190005 0.0504461710991985 1.0 0.4252333686521401 81 Q9HCE1,P60900,P49720,P28070,P28074,Q13362,P20618,P49356,P30086,Q15334,O60725,P49721,Q9Y4G8,Q14168 14 Trans golgi network vesicle budding 0.5306133159911177 1.93169973268429 0.0533965777991916 1.0 0.4293337516253295 35 Q8NC96,O60749,O00443,Q92538,P20645,Q9BXS5,P02786,Q9H3P7,Q14677,Q92572,Q9Y5X1,P05067,P15586 13 Heme signaling 0.8133109913733043 1.9306490604865136 0.0535264663686096 1.0 0.4293337516253295 5 Q15648,Q09472,P09601 3 Anchoring of the basal body to the plasma membrane 0.5395377931235908 1.9289263374882064 0.0537400076478016 1.0 0.4293337516253295 28 P63167,Q9H6D7,P04350,Q7Z460,P07437,P43034,P68371 7 Golgi associated vesicle biogenesis 0.5372068999154933 1.918731447231992 0.0550183295205166 1.0 0.4293337516253295 29 Q8NC96,O60749,O00443,Q9BXS5,P02786,Q9H3P7,Q14677,Q92572,Q9Y5X1,Q01968,P56377,P11717 12 Diseases associated with glycosylation precursor biosynthesis 0.7419690079843748 1.916284391225021 0.0553289065511179 1.0 0.4293337516253295 8 P16278,P10619 2 Separation of sister chromatids 0.4724408720298608 1.9003913970657105 0.0573817750522589 1.0 0.4293337516253295 98 P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q9BUF5,P49721,Q13509,P68371,Q13885 12 Metabolism of folate and pterines 0.7369419730379735 1.8938764314973853 0.0582414135111035 1.0 0.4293337516253295 8 P00374 1 Negative regulation of mapk pathway 0.6573105504629416 1.8791075361128853 0.0602298113455803 1.0 0.4343852098543753 12 Q13362 1 Transport of small molecules 0.5079712695756026 1.8779794950769064 0.0603839702199313 1.0 0.4343852098543753 138 P08183,P30519,P21796,P45880,O43242,P49720,Q9UBX3,Q9BUN8,P09601,Q8WTV0,Q9C0H2,Q9Y487,P53985,P60900,P28070,Q8N4V1,Q96CW1,P20618,O15118,P49721,Q9HD20,P04920,Q70HW3,Q6PIU2,P35613,Q99808,Q93050,Q8TB61,Q9GZP9,Q4KMQ2,Q9H300,Q9BPX6,Q9Y6M7,P28074,P25788,Q9Y3S1,P21281,P35611,Q9Y277 39 Degradation of beta catenin by the destruction complex 0.4957196019652607 1.854656199881771 0.0636453372046437 1.0 0.4497197942917751 45 P60900,P49720,P28070,Q13362,P49721 5 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.8682189147288311 1.8188626596606203 0.0689323858718029 1.0 0.4735654909392863 4 Q8NB78,Q9HCE1 2 L1cam interactions 0.5054033528433902 1.8017609625918944 0.0715830220356541 1.0 0.4869062984009346 39 Q9BVA1,P04350,Q9BUF5,Q15334,O00560,Q13509,P68371,Q13885 8 Mitotic prometaphase 0.4485385125185143 1.7951158167350545 0.0726352492555539 1.0 0.4893344622525587 85 Q9H6D7,Q9BVA1,Q13362,P04350,Q9BUF5,P07437,Q13509,P68371,Q13885 9 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5762202619046836 1.7950089232820856 0.0726522782383711 1.0 0.4893344622525587 19 Q9Y5P6,P16278,Q86YN1,P10619,Q9Y223 5 Regulation of hmox1 expression and activity 0.494730056444256 1.754561884320452 0.0793342759241639 1.0 0.5046541440731541 41 P60900,P49720,P28070,P09601,P49721 5 Synaptic adhesion like molecules 0.736187169296552 1.737332768046693 0.0823284508440578 1.0 0.5188958323841076 6 P10586,O95197 2 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.6461102874454188 1.7283040325191128 0.0839337304854348 1.0 0.5265979255113583 10 P05067,O15111,P09601,Q13685 4 Selenoamino acid metabolism 0.4417931000191097 1.724952732339037 0.0845359912118983 1.0 0.5279656905688561 85 Q9Y3U8,P15880,Q9P2J5,P39023,P32969,P50914,Q13155,O43324,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,Q12904,O43252,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P23526,P36578,P46781,P47914,P00390,P61254,P08708,P32929,P46783,Q07020,P83881 46 Glutathione synthesis and recycling 0.8426199956210475 1.7191068860469894 0.0855949111766514 1.0 0.5297630989041399 4 Q96KP4,P48507 2 Negative regulation of the pi3k akt network 0.6111484215763812 1.6905332885441997 0.0909259752625475 1.0 0.5541077367963831 13 Q13362 1 Gamma carboxylation hypusine formation and arylsulfatase activation 0.6615917310289824 1.6832651330499124 0.0923237769519982 1.0 0.5541077367963831 9 O43681,O60725,P49366,P38435 4 Metabolism of steroids 0.4939666271665081 1.6810429610357485 0.0927545702060903 1.0 0.5541077367963831 37 Q9BWD1,Q15436,Q14534,Q15648,P04062,Q15800,Q86X55,Q16850,P22059,Q15392,Q14739,P62826,P38435 13 Slc mediated transmembrane transport 0.5458271049073931 1.667590165535897 0.0953971118473093 1.0 0.5636093562379911 20 P35613,Q9UBX3,Q9Y6M7,Q8TB61,P53985,Q70HW3 6 Mitotic g1 phase and g1 s transition 0.4219042423864535 1.6666919377649487 0.0955756768584075 1.0 0.5636093562379911 72 P62191,P00374,P49720,O43242,P11802,P27694,P49643,Q7L590,Q07864,Q13309,O43913,Q00534,P14635,Q13616,P60900,P28070,O00487,P25787,P20618,P33992,P49721,P09884,P30153,P35244,P15927,O75832,P25786,P30154,P49736,P51665,Q9NRF9,Q9UL46,P28074,P25788,P06493,P12004,Q14566,P62333,Q9Y619 39 Stimuli sensing channels 0.7040638963578287 1.617873177367845 0.105689931868051 1.0 0.5892371338391466 7 Q4KMQ2,Q9C0H2 2 Regulation of plk1 activity at g2 m transition 0.4926385265223802 1.6167815065569353 0.1059254527352759 1.0 0.5892371338391466 32 Q9H6D7,P07437,P68371,P04350 4 Asparagine n linked glycosylation 0.4548249570662657 1.6044194273929149 0.1086216315593007 1.0 0.5993820151103582 109 P63167,P24390,Q9BVA1,Q9Y296,Q9Y5P6,P10619,P49257,P68371,Q13885,Q12955,P04350,P16278,Q86YN1,P04066,O14579,Q2TAA5,Q9GZP9,Q9BUF5,Q13509,Q9UJW0,Q15436,Q9Y223 22 Synthesis of pa 0.6968025439000187 1.5859762416853844 0.1127446991096638 1.0 0.6147270499074531 7 Q9NPH0 1 Neddylation 0.4023335102889865 1.5808573619643065 0.1139106553055688 1.0 0.6186294086555401 62 P49720,O43242,Q8TBC4,Q13309,P60900,P28070,P20618,Q9BTE7,P49721,Q92905,Q99627,Q15345,Q96GG9,P61962,Q13617,P28074,P25788,O94888,Q9BT78 19 Ion channel transport 0.4911214372417709 1.578797194278149 0.1143825823737401 1.0 0.6187467251240902 25 Q93050,P21281,Q9C0H2,Q9HD20,Q9Y487,Q4KMQ2 6 Glycogen storage diseases 0.8027842227378141 1.562587697158004 0.1181496038928657 1.0 0.6278260877070667 4 P46976,O43826,P10253 3 Srp dependent cotranslational protein targeting to membrane 0.4259606073384402 1.5589524435464055 0.1190076364024179 1.0 0.6278260877070667 85 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P49458,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P43307,Q15005,Q15629,P67812,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P36578,P46781,P47914,Q9Y5M8,P61254,P08708,P46783,Q07020,P83881 44 Glycogen metabolism 0.6346486527270284 1.5547305792631252 0.1200102485709055 1.0 0.6278260877070667 9 P46976,P10253,P35573 3 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4970114373369417 1.5451888036441224 0.1223006017594383 1.0 0.6328525349421347 23 Q13126,Q53EL6 2 Sphingolipid de novo biosynthesis 0.6072392002742127 1.5345949656772957 0.1248833500467692 1.0 0.637002275378253 10 P51648,P22059,O95470,Q96G23,Q9Y5P4 5 Hedgehog ligand biogenesis 0.4749888807219609 1.5331416959348323 0.125240946108365 1.0 0.637002275378253 37 P60900,P49720,P28070,Q9GZP9,P49721 5 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.6845136219269978 1.5318358216896757 0.1255629539378282 1.0 0.637002275378253 7 Q09472,Q99873,P06493,Q86X55,P12004 5 Traf6 mediated nf kb activation 0.6879113588228367 1.5275879590660952 0.1266148732010634 1.0 0.637002275378253 6 P09429,P05067 2 Heme degradation 0.9729677287159932 1.5270028407791203 0.1267603049757002 1.0 0.637002275378253 3 P30519 1 Ras processing 0.793029126292591 1.5240621869626196 0.1274931773864771 1.0 0.637002275378253 4 O60725 1 Activation of nima kinases nek9 nek6 nek7 0.7148217680314228 1.5197727177553713 0.128568108187014 1.0 0.6383696300116408 5 P14635,P06493 2 Phase i functionalization of compounds 0.558630415922752 1.506826201765114 0.1318552115688325 1.0 0.6441695392371791 15 P07099,Q16850,Q86WA6,O43169 4 Mismatch repair 0.5930493624683979 1.50389171373093 0.1326092509438514 1.0 0.6441695392371791 11 Q9UQ84,P28340,P43246,P12004,P52701,P35244,P15927 7 Abc family proteins mediated transport 0.4484527986314578 1.5035613595172173 0.1326943467164207 1.0 0.6441695392371791 47 P08183,P60900,P49720,P28070,Q9GZP9,P49721 6 Cytosolic sulfonation of small molecules 0.7875356176816077 1.5023391857270882 0.1330095334638423 1.0 0.6441695392371791 4 Q8TB61 1 Interleukin 12 signaling 0.4791145631589107 1.493561117024169 0.1352903687530808 1.0 0.6476967479677113 25 Q13126,Q53EL6 2 Pyruvate metabolism 0.5314255179168311 1.473286306663804 0.1406738514252361 1.0 0.6585759971633327 18 P35613,P53985,P21796,Q16775 4 Glycogen breakdown glycogenolysis 0.6745672969446779 1.4691012567035238 0.1418053269638295 1.0 0.6585759971633327 6 P10253,P35573 2 Abc transporter disorders 0.4634155770001931 1.46883837004981 0.1418766340322752 1.0 0.6585759971633327 39 P60900,P49720,P28070,P28074,Q9BUN8,P25788,P20618,Q9GZP9,P49721 9 Defective cftr causes cystic fibrosis 0.463415577000193 1.468838370049809 0.1418766340322754 1.0 0.6585759971633327 39 P60900,P49720,P28070,P28074,Q9BUN8,P25788,P20618,Q9GZP9,P49721 9 Synthesis of pips at the plasma membrane 0.6416487239702718 1.4605508149349404 0.1441387526288315 1.0 0.661707999917728 8 O00443,Q8TBX8 2 Metalloprotease dubs 0.6710816381060436 1.4537940278248065 0.1460034197482986 1.0 0.661707999917728 6 O00487,O95630,Q09472,Q15018 4 Cyclin a cdk2 associated events at s phase entry 0.4630987678088186 1.4523507644026223 0.1464040989628743 1.0 0.661707999917728 38 P60900,P49720,P28070,P11802,P49721 5 Scf skp2 mediated degradation of p27 p21 0.4630987678088187 1.4523507644026223 0.1464040989628743 1.0 0.661707999917728 38 P60900,P49720,P28070,P11802,P49721 5 Tp53 regulates transcription of cell cycle genes 0.5625477327632967 1.4310266200406785 0.1524225860067556 1.0 0.6758455886397821 13 Q09472,Q9UKZ1,Q99873,P06493,Q86X55,Q9NZN8 6 G1 s dna damage checkpoints 0.4571022144038706 1.4046238391992174 0.1601331638923504 1.0 0.6844387198743559 38 P60900,P49720,P28070,P28074,P25788,P20618,O14757,Q13315,P49721 9 Hs gag degradation 0.9327369118621684 1.3816705489023338 0.1670728812181288 1.0 0.7047148468289943 3 P16278,P08236 2 Rora activates gene expression 0.7569830427638743 1.3812468117673016 0.1672030859288589 1.0 0.7047148468289943 4 Q15648,Q09472 2 Lysosome vesicle biogenesis 0.5527912152938863 1.378377399280134 0.1680867975718061 1.0 0.7062729659439193 13 P05067,P20645,P15586 3 Diseases of glycosylation 0.500802711585405 1.3334122669276185 0.1823965490048176 1.0 0.7505731743038118 19 Q8NCH0,P16278,P10619 3 Fatty acyl coa biosynthesis 0.5212843245155505 1.3302626457536184 0.1834317500407998 1.0 0.7505731743038118 16 P50897,Q9NZ01 2 Apc c mediated degradation of cell cycle proteins 0.4128522575965936 1.3241069179086342 0.1854675383761499 1.0 0.7505731743038118 52 P62191,P49720,O43242,Q13042,Q13309,P14635,Q13257,Q13616,P60900,P28070,O00487,P25787,P20618,P30260,P49721,O75832,P53350,P51665,Q9UJX4,Q9UL46,P28074,P25788,O43684,P06493,P62333 25 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4346475463509924 1.3164384907268052 0.188026910577493 1.0 0.7505731743038118 44 P62191,P49720,O43242,Q13042,Q13309,P60900,P28070,O00487,P25787,P20618,P30260,P49721,O75832,P53350,P51665,Q9UJX4,Q9UL46,P28074,P25788,P62333 20 Tnfr2 non canonical nf kb pathway 0.4459302961837441 1.3154049954529936 0.1883738275465531 1.0 0.7505731743038118 38 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721 9 Dectin 1 mediated noncanonical nf kb signaling 0.4459302961837441 1.3154049954529936 0.1883738275465531 1.0 0.7505731743038118 38 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721 9 Degradation of axin 0.4516459507393801 1.3143306997654152 0.1887349403937372 1.0 0.7505731743038118 33 P60900,P49720,P49721,P28070 4 Cross presentation of soluble exogenous antigens endosomes 0.4516459507393801 1.3143306997654152 0.1887349403937372 1.0 0.7505731743038118 33 P60900,P49720,P49721,P28070 4 Phosphorylation of the apc c 0.5486774138837776 1.3137829563549266 0.1889192547819249 1.0 0.7505731743038118 12 Q9UJX4,P30260,Q13042,P06493,P14635 5 Regulation of ras by gaps 0.4501998196670569 1.3101502961614866 0.1901449963778656 1.0 0.7505731743038118 34 P60900,P49720,P49721,P28070 4 Degradation of dvl 0.4501998196670569 1.3101502961614866 0.1901449963778656 1.0 0.7505731743038118 34 P60900,P49720,P49721,P28070 4 Cellular response to hypoxia 0.4476539183794697 1.3074146451309134 0.1910719261599596 1.0 0.7505731743038118 36 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721 8 Transport and synthesis of paps 0.8963232858562469 1.3041569614847268 0.192180070756295 1.0 0.7505731743038118 2 Q8TB61 1 Plasma lipoprotein clearance 0.5537252128351091 1.3007302026519214 0.193350820340072 1.0 0.7505731743038118 11 Q8WTV0 1 Stabilization of p53 0.4463301597506778 1.2970162406840309 0.194625598845044 1.0 0.7505731743038118 36 P60900,P49720,P28070,P28074,P25788,P20618,Q13315,P49721 8 Proton coupled monocarboxylate transport 0.894335872805565 1.2963038101665665 0.1948708364211384 1.0 0.7505731743038118 2 P53985 1 Transport of bile salts and organic acids metal ions and amine compounds 0.894335872805565 1.2963038101665665 0.1948708364211384 1.0 0.7505731743038118 2 P53985 1 Apc c cdc20 mediated degradation of cyclin b 0.552814773073356 1.2960039911721244 0.1949741098503599 1.0 0.7505731743038118 11 P30260,P06493,Q13042,Q9UJX4 4 Hdr through homologous recombination hrr 0.48694075920859 1.2956405560675817 0.1950993498282938 1.0 0.7505731743038118 20 Q9UQ84,Q9NRF9,P28340,O14757,Q13315,P12004,P40938,P15927 8 Endosomal sorting complex required for transport escrt 0.5583192885615542 1.287221708364948 0.198017022888268 1.0 0.7578701655946527 10 Q8WUX9 1 Cargo trafficking to the periciliary membrane 0.4929323002690655 1.2844500063255946 0.198984545499683 1.0 0.7594576819904569 19 A6NIH7 1 Regulation of runx3 expression and activity 0.4442884632916201 1.2721573084851896 0.2033172326296384 1.0 0.7635123098033796 35 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721 8 Interleukin 12 family signaling 0.4464564168640065 1.2572983614445137 0.2086456171083626 1.0 0.766780988510874 27 Q13126,Q53EL6 2 Hedgehog on state 0.4393768247958228 1.252007445650841 0.2105671508898239 1.0 0.7715180408603147 37 Q96J02,P60900,P49720,P28070,P28074,P25788,P20618,P49721 8 Signaling by notch4 0.4337771179117499 1.242815999261291 0.2139356454055092 1.0 0.7783009384566677 40 Q09472,P28070,Q9Y6A5,O43242,P49720,P60900,P28074,P25788,P20618,P49721 10 Oncogene induced senescence 0.621980997342054 1.2372751123453594 0.2159849641661706 1.0 0.7789064062055603 6 P11802,Q9HCE1 2 Sulfur amino acid metabolism 0.5394053628705667 1.2263187706712382 0.2200787403614286 1.0 0.7902494025578933 11 Q13126 1 Runx3 regulates p14 arf 0.8764491553494544 1.2257823706340334 0.2202805831001988 1.0 0.7902494025578933 2 Q09472 1 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.565777415721931 1.2215660000363178 0.2218717926814117 1.0 0.7915251399294022 9 P63104,O14757,Q04917,P06493,P14635 5 Synthesis of pg 0.874130506790332 1.216664564739836 0.2237318665069398 1.0 0.7925963861933503 2 Q8IV08 1 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.5429230185163237 1.2088591165153084 0.2267169752667222 1.0 0.7925963861933503 10 P30260,Q13309,Q13042 3 Uch proteinases 0.4276397839628847 1.206469761415638 0.2276364116299019 1.0 0.7925963861933503 41 P60900,P49720,P28070,Q8NB78,P20618,P49721 6 Plasma lipoprotein assembly remodeling and clearance 0.5197562097012829 1.1992052007100666 0.2304481655371097 1.0 0.7925963861933503 13 Q8WTV0 1 Resolution of d loop structures 0.639388240439676 1.1989255154688772 0.2305569093325088 1.0 0.7925963861933503 5 Q9UQ84 1 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.639388240439676 1.1989255154688772 0.2305569093325088 1.0 0.7925963861933503 5 Q9UQ84 1 Eukaryotic translation initiation 0.4030496727404566 1.1945742632641871 0.2322534096735955 1.0 0.7925963861933503 96 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P49770,P62829,P84098,Q9NR50,P27635,P18621,P55010,P30050,P46782,P61513,Q13144,P62753,Q15056,Q02543,O15372,P62701,P62244,P62917,P83731,P62266,Q9Y262,P62888,Q14232,O75821,P46779,Q02878,P61313,P62241,P35268,P05198,P62841,P62280,P46778,P18077,P62249,P23396,P36578,P46781,P47914,P61254,P08708,P62847,P62277,O00303,P46783,Q07020,O75822,Q14240,P83881 55 Pexophagy 0.8675057966213997 1.190648986381524 0.2337914122815343 1.0 0.7931590135180941 2 P50542 1 Fanconi anemia pathway 0.6362513858150466 1.1855629072940583 0.2357949579345084 1.0 0.7962266907552972 5 P27694,P35244,P15927 3 Negative regulation of notch4 signaling 0.430515705026758 1.18156430233227 0.2373786249468326 1.0 0.7962266907552972 37 P60900,Q9Y6A5,P49720,P28070,P28074,P25788,P20618,P49721 8 Metabolism of polyamines 0.431981210997167 1.1761281042419518 0.2395436888505777 1.0 0.7962266907552972 35 P60900,P49720,P49721,P28070 4 Nonsense mediated decay nmd 0.3836872888927029 1.1658172497726824 0.2436883413903203 1.0 0.7962266907552972 80 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,Q02543,P62917,P62701,P62244,P30153,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,P36578,P46781,P47914,P61254,P08708,P46783,Q07020,P83881 39 Switching of origins to a post replicative state 0.3823466776600789 1.1642161200749093 0.2443364390974765 1.0 0.7962266907552972 56 P62191,P49720,O43242,Q13042,Q13309,O43913,Q13616,P60900,P28070,O00487,P25787,P20618,P33992,P30260,P49721,O75832,P25786,P49736,P51665,Q9UJX4,Q9UL46,P28074,P25788,Q14566,P62333,Q9Y619 26 Mapk6 mapk4 signaling 0.4187557480333341 1.163350525575925 0.2446873138748175 1.0 0.7962266907552972 43 Q9HCE1,P60900,P49720,O43242,P28070,O00487,Q9UL46,P28074,P25788,P20618,P06493,P63000,P49721 13 Tcf dependent signaling in response to wnt 0.3704201843475109 1.159964088621393 0.2460634274656208 1.0 0.7962266907552972 59 P60900,P49720,P28070,Q13362,P49721 5 Degradation of gli1 by the proteasome 0.4269354268086349 1.1530743449903538 0.2488798707465656 1.0 0.7962266907552972 37 Q96J02,P60900,P49720,P28070,P28074,P25788,P20618,P49721 8 Mitotic metaphase and anaphase 0.4294680884551644 1.1516585568901163 0.249461408603733 1.0 0.7962266907552972 128 P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q86XL3,Q9BUF5,P49721,Q9BTX1,Q8WUX9,Q13509,P68371,Q13885 15 Transcriptional regulation by runx3 0.424028067203475 1.1506889596353094 0.2498602201273043 1.0 0.7962266907552972 39 P60900,Q09472,P49720,P28070,P28074,P25788,P20618,P49721,P25440 9 Association of tric cct with target proteins during biosynthesis 0.4841575232977496 1.1483659285569032 0.250817532894473 1.0 0.7962266907552972 17 P78371,Q9H0D6,P51784,P04062 4 Auf1 hnrnp d0 binds and destabilizes mrna 0.4260394459302001 1.1459429438907744 0.2518187608354969 1.0 0.7962266907552972 37 P60900,P49720,P49721,P28070 4 Unwinding of dna 0.57322093444916 1.1426087686870778 0.2532010632242083 1.0 0.7962266907552972 8 P49736,P33991,Q9BRX5,P33992,Q14566,P33993 6 Bicarbonate transporters 0.8545876117919885 1.140088054778334 0.2542496179742912 1.0 0.7962266907552972 2 Q9Y6M7 1 Crmps in sema3a signaling 0.6227708439441089 1.1281885758895005 0.2592402875558104 1.0 0.7962266907552972 5 Q9BPU6 1 Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.8566399736387251 1.108117969256621 0.2678108714740175 1.0 0.7962266907552972 3 P11802 1 Constitutive signaling by akt1 e17k in cancer 0.8456442530639294 1.105235830273454 0.2690574150298439 1.0 0.7962266907552972 2 P42345 1 Asymmetric localization of pcp proteins 0.4236503853823279 1.1047961946806382 0.2692479097809315 1.0 0.7962266907552972 34 P60900,P49720,P49721,P28070 4 Signaling by the b cell receptor bcr 0.4128345862091722 1.0838483475214613 0.2784320446304522 1.0 0.7962266907552972 41 P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721,O43865 9 Downstream signaling events of b cell receptor bcr 0.4167190400806594 1.080940871562286 0.2797234163465418 1.0 0.7962266907552972 38 P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721 8 Bmal1 clock npas2 activates circadian gene expression 0.8469184890656232 1.0735318227781063 0.2830325684760291 1.0 0.7962266907552972 3 Q15648,P43490 2 Interleukin 1 family signaling 0.4061186116881179 1.0725787499782815 0.2834601633196418 1.0 0.7962266907552972 44 P60900,P49720,P28070,P28074,P25788,P20618,P05067,P49721,O15111,P09429 10 Regulation of mecp2 expression and activity 0.534334766380861 1.0685748459985025 0.2852612879867815 1.0 0.7962266907552972 9 Q14739,P42858 2 Interleukin 1 signaling 0.4073914863252091 1.0671590731707998 0.2859000101537554 1.0 0.7962266907552972 43 P60900,P49720,P28070,P28074,P25788,P20618,P05067,P49721,O15111,P09429 10 Vitamin b5 pantothenate metabolism 0.6760639167452873 1.060655495232985 0.2888464924077776 1.0 0.7997424458771506 4 Q9NRN7 1 Regulation of expression of slits and robos 0.4058817995025723 1.0579865741591667 0.2900615633392236 1.0 0.7997424458771506 112 Q9Y3U8,P62191,P15880,P49720,O43242,P50914,P39023,P32969,P46776,P62829,P84098,P60900,P28070,P27635,O00487,P18621,P25787,P20618,P30050,P46782,P61513,P62753,P49721,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,O75832,P25786,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P62249,P23396,Q13617,P36578,P46781,P47914,P51665,Q9UL46,P28074,P61254,P25788,P08708,P62847,P62277,P46783,Q07020,P62333,P46777,P83881 60 Role of phospholipids in phagocytosis 0.8423994329735425 1.0574982200707927 0.2902842665280021 1.0 0.7997424458771506 3 Q8IV08 1 Antigen processing cross presentation 0.4043156085434212 1.057145832215586 0.2904450367486886 1.0 0.7997424458771506 44 P60900,P49720,P28070,P28074,Q9UIQ6,P25788,P20618,O15111,P49721,P09429 10 Synthesis of dna 0.3700322650904628 1.053732913661063 0.2920052154612209 1.0 0.8016586467473256 77 P62191,P49720,O43242,P27694,P49643,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 36 Diseases of dna repair 0.5309884759137057 1.0523170720653934 0.2926541015863004 1.0 0.8016586467473256 9 Q13315,Q9UQ84 2 Cargo recognition for clathrin mediated endocytosis 0.4173910609037531 1.0496507092141372 0.2938787336281574 1.0 0.8016586467473256 25 Q8NC96,P20645,Q96CW1,P02786,Q92905,Q99627,Q14108,Q9NVZ3 8 Antigen processing ubiquitination proteasome degradation 0.3748969651324501 1.0486505769763068 0.2943389688099826 1.0 0.8016586467473256 82 Q96J02,P49720,O43242,Q8TBC4,Q13042,Q13309,P61088,P60900,P28070,P30260,P20618,P19474,P55786,P49721,O94822,Q9UIQ6,Q15345,Q13617,P28074,P25788,Q15386,P52888 22 Basigin interactions 0.5485876818621762 1.0280775564257585 0.303913347020581 1.0 0.8187783113848596 8 P35613,P53985,Q9UPY5,Q13356 4 Clec7a dectin 1 signaling 0.3972758326119757 1.0137016908440863 0.3107251170203697 1.0 0.8273959511356358 45 P60900,P49720,P28070,P28074,P25788,P20618,Q8TBC4,O15111,P49721,O43865 10 Budding and maturation of hiv virion 0.5442861753629673 1.008133548272237 0.3133903540283247 1.0 0.8302350458821092 8 Q8WUX9,A5D8V6 2 Cellular response to starvation 0.3710885314369298 1.007813545606842 0.3135439818041985 1.0 0.8302350458821092 82 Q9Y3U8,P15880,P50914,P39023,P32969,P46776,P62829,P84098,P27635,P18621,P30050,P46782,P61513,P62753,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P42345,P46779,Q02878,P61313,P62241,P35268,P05198,P62841,P62280,P46778,P18077,P62249,P08243,Q96EE3,P23396,P36578,P46781,P47914,P61254,P21281,P08708,P62847,P62277,P46783,Q07020,P83881 47 Glutathione conjugation 0.488911918212218 0.996191975344359 0.3191568776542568 1.0 0.8365791337088914 12 P78417,P48507 2 C type lectin receptors clrs 0.3855951997908317 0.9904294057287858 0.3219642784006411 1.0 0.8394286878984457 49 P60900,P49720,Q09472,P28070,P28074,P25788,Q8TBC4,P20618,O15111,P49721,O43865 11 Sema3a pak dependent axon repulsion 0.5648326894800518 0.9854159424524804 0.3244198018746353 1.0 0.8418505002246173 6 O14786,P07900 2 Cytosolic iron sulfur cluster assembly 0.5648048154247706 0.9852938872654936 0.3244797344261227 1.0 0.8418505002246173 6 Q9Y5Y2,P18074,Q96T76,P28340 4 Signaling by notch2 0.8135144087446208 0.9813359090049206 0.3264271202810045 1.0 0.8418505002246173 2 Q09472 1 Activated notch1 transmits signal to the nucleus 0.8135144087446196 0.981335909004916 0.3264271202810067 1.0 0.8418505002246173 2 Q96J02 1 Metabolism of nitric oxide nos3 activation and regulation 0.5876115047573427 0.9793362745485348 0.327413852688331 1.0 0.8424468793890764 5 P35270 1 Nectin necl trans heterodimerization 0.8102020536601577 0.9687023132412516 0.3326937380714863 1.0 0.8496676507624947 2 Q9BY67 1 Rac2 gtpase cycle 0.406096566701154 0.9620119954881824 0.3360435783691633 1.0 0.8545084063529333 32 Q13505,Q86XL3,Q9Y512,Q8TAA9,Q14739,P49257,O15173 7 Keratan sulfate keratin metabolism 0.5588304314172741 0.9591639065326204 0.3374761801852517 1.0 0.8545084063529333 6 P16278,P15586 2 Protein protein interactions at synapses 0.4753938915195445 0.9581102268518508 0.3380071790618009 1.0 0.8545084063529333 13 P10586,O95197,Q15334 3 Cdt1 association with the cdc6 orc origin complex 0.4023541023148697 0.9574886945957884 0.3383206499679736 1.0 0.8545084063529333 37 P60900,P49720,P28070,P28074,P25788,P20618,P49721,O43913,Q9Y619 9 Dual incision in gg ner 0.4111551063751754 0.9503460425126644 0.3419364510500617 1.0 0.8600019412978067 23 Q9NRF9,P28340,Q9UGN5,Q86WJ1,P12004,P19447,P40938,P32780,P15927 9 Orc1 removal from chromatin 0.3854952209613809 0.9475210972052612 0.3433733110231918 1.0 0.8600019412978067 47 P60900,P49720,P28070,P28074,P25788,P20618,P49721,O43913,Q14566,Q9Y619 10 Homologous dna pairing and strand exchange 0.472767089510165 0.943891647582158 0.3452250206515377 1.0 0.8600019412978067 13 Q13315,Q9UQ84,O14757,P40938 4 Pyroptosis 0.6457356287627627 0.942046310591106 0.3461689304174749 1.0 0.8600019412978067 4 Q8WUX9 1 Myoclonic epilepsy of lafora 0.8022524014574388 0.9385067963828024 0.3479840259054407 1.0 0.8614955884577938 2 P46976 1 Repression of wnt target genes 0.8006871777249014 0.9111843552272344 0.3621982457723369 1.0 0.8810166737413452 3 Q13363 1 Dna replication initiation 0.5710865384504784 0.910061408310373 0.3627901254142043 1.0 0.8810166737413452 5 P09884,Q07864,Q9NRF9 3 Role of abl in robo slit signaling 0.799921229027953 0.9085316781736495 0.3635973848886773 1.0 0.8810166737413452 3 Q7Z460 1 Mapk3 erk1 activation 0.63678511175373 0.9073819428747364 0.364204854938198 1.0 0.8810166737413452 4 P06493 1 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5004207240738598 0.9044792114571634 0.3657413526923618 1.0 0.8831785915629266 9 P30260,Q13042 2 Transcriptional regulation by runx2 0.3843528071198292 0.9020634911364268 0.3670231414222524 1.0 0.8847189409020612 45 P60900,P49720,P28070,P11802,P49721 5 Resolution of abasic sites ap sites 0.3963443252420567 0.8938951153999465 0.3713780114928624 1.0 0.890529472584979 26 Q96T60,Q9NRF9,Q86W56,Q9UGN5,P28340,P12004,Q07864,P40938,P29372,P15927 10 Leishmania infection 0.3929685524671498 0.8904045313418802 0.3732487101306299 1.0 0.8927495870769729 38 P05067,P09601,Q9UQB8 3 Regulation of runx2 expression and activity 0.3925582111103375 0.8871250676717507 0.3750115692887599 1.0 0.8945588475742294 38 P60900,P49720,P49721,P28070 4 Purine ribonucleoside monophosphate biosynthesis 0.4962104419914216 0.8842568329915925 0.3765575849653646 1.0 0.8966899856887539 9 Q06203,P30566,P30520,P22102 4 Rho gtpase effectors 0.3814800918163463 0.8808864273822506 0.3783792943770869 1.0 0.8994691184673312 104 P63167,P33176,Q9BVA1,Q13362,P04350,Q7Z460,P49454,Q9BUF5,Q15334,O15145,Q9UQB8,P43034,P60660,Q13509,P68371,Q13257,Q13885,Q9P258 18 Met activates ras signaling 0.6293230818993264 0.8786311610786575 0.3796012944154507 1.0 0.9008155069548004 4 Q96S59,P62993 2 Stat3 nuclear events downstream of alk signaling 0.624665340945109 0.8607606918699462 0.3893698585533871 1.0 0.9098540572318944 4 Q09472 1 Keratan sulfate degradation 0.6229242626032024 0.8540965002855694 0.3930515228786453 1.0 0.9150440456899565 4 P16278 1 Tcr signaling 0.3787031405078307 0.853432037811677 0.393419761196959 1.0 0.9150440456899565 45 P50552,P60900,P49720,P28070,P28074,P25788,P20618,O15111,P49721 9 Vitamin d calciferol metabolism 0.7827055323488716 0.8493084782810583 0.3957096644025228 1.0 0.915620153324307 3 P04062 1 Regulation of mrna stability by proteins that bind au rich elements 0.3468376141797332 0.8411746831390152 0.4002500812163649 1.0 0.9211356874552782 57 P60900,P49720,P28070,P28074,Q9NQT4,Q15024,P25788,P20618,P49721,Q92945,Q9NQT5 11 Carnitine metabolism 0.5542520023258284 0.8401802212678334 0.4008073463356296 1.0 0.9211356874552782 5 P23786 1 Processive synthesis on the c strand of the telomere 0.4685456661731371 0.8319117706379653 0.4054587474046567 1.0 0.925981924981828 10 P35244,P28340,P12004,Q15554,P15927 5 Ddx58 ifih1 mediated induction of interferon alpha beta 0.4458017494584589 0.8311110348358159 0.4059109064961848 1.0 0.925981924981828 14 Q96J02,Q09472,P07900,P05067,O15111,P09429 6 Glycogen synthesis 0.5514778120310384 0.8287455206942144 0.4072484216049798 1.0 0.925981924981828 5 P46976 1 Response to elevated platelet cytosolic ca2 0.3876088435354153 0.8213131100176164 0.4114679420570137 1.0 0.9328610308427115 31 P07602,Q9NZJ7,Q9NUQ9,Q8NBX0,P07737,Q6UXV4,Q01518,P13473,P05067,Q08380,O94919,O43852 12 Pi metabolism 0.4372651329542798 0.8184052389922613 0.4131258312220125 1.0 0.9328610308427115 15 O00443,Q9Y217,Q8TBX8 3 Signaling by robo receptors 0.395613779900809 0.8134954241807696 0.4159340687275659 1.0 0.9328610308427115 126 Q9Y3U8,P62191,P15880,P49720,O43242,P50914,P39023,P32969,Q01518,P63000,P46776,P35080,P62829,P84098,O14786,P60900,P28070,P50552,P27635,O00487,P18621,Q7Z460,P25787,P20618,P30050,P46782,P07737,P61513,P49721,Q02543,P62917,P62701,P62244,P83731,P62266,P62888,P46779,Q02878,P61313,P62241,P35268,P62841,P62280,P46778,P18077,P23396,Q13617,P36578,P46781,P47914,P51665,Q9UL46,P28074,P61254,P25788,P08708,P46783,Q07020,P62333,P83881 60 Small interfering rna sirna biogenesis 0.7685637475554474 0.8012958811895907 0.4229603747593886 1.0 0.9328610308427115 3 Q15631 1 Pcp ce pathway 0.3771666674992053 0.8002863667521996 0.4235449001145386 1.0 0.9328610308427115 42 P60900,P49720,P28070,Q96CW1,P28074,P25788,P20618,P07737,P49721 9 Signaling by notch3 0.5220718986909788 0.8002192863847781 0.4235837574847547 1.0 0.9328610308427115 6 Q09472,Q9Y6A5 2 Potential therapeutics for sars 0.3839962689033079 0.796403980964158 0.4257972651021113 1.0 0.9345773837864232 33 P07437,Q99720 2 Hdr through single strand annealing ssa 0.44811143656846 0.7816579659955455 0.4344156109033728 1.0 0.944857870440316 12 Q13315,Q9UQ84,P40938 3 Regulated necrosis 0.436701533342303 0.7813322386516074 0.4346071136232021 1.0 0.944857870440316 14 P09429,O00560,Q8WUX9,Q8WUM4 4 Aryl hydrocarbon receptor signalling 0.7621427446365032 0.7797091065320559 0.4355621174169815 1.0 0.945147331520817 3 O00170 1 Adaptive immune system 0.4285728394011189 0.7738467764293725 0.4390214070071683 1.0 0.945147331520817 171 Q96J02,P63167,P49720,O43242,Q9BVA1,Q13362,Q8TBC4,Q13042,P10619,P68371,Q13885,P47755,P33176,P50552,P60900,P28070,Q9BXS5,Q96CW1,P04350,P30260,P20618,P19474,P55786,P49721,O43865,O94822,P42345,Q9UIQ6,Q9BUF5,O15111,Q15345,P09429,Q13509,Q9UJW0,Q9NZ08,Q15436,P28074,P25788,Q15386,P52888 40 Activation of the pre replicative complex 0.4047767214342979 0.771236588349531 0.4405667107485134 1.0 0.945147331520817 20 P49736,Q9NRF9,P27694,P49643,Q7L590,P33992,Q07864,O43913,Q14566,Q9Y619,P09884,P35244,P15927 13 Clathrin mediated endocytosis 0.3604402310567012 0.7631972815828544 0.4453457497630768 1.0 0.945979993505518 49 Q8NC96,O00443,Q15642,P20645,P02786,Q96CW1,Q9Y5X1,Q99627,Q14108,Q9NVZ3,O15145 11 Nef mediated downregulation of mhc class i complex cell surface expression 0.5350128396509777 0.7614434653185964 0.4463922343701423 1.0 0.945979993505518 5 P56377,Q9BXS5 2 Circadian clock 0.4534082486360659 0.7567101654144539 0.4492235232974919 1.0 0.9476637886917731 10 P43490,Q15648,Q09472 3 Metabolism of water soluble vitamins and cofactors 0.378449404638523 0.7544740706985182 0.4505646093162347 1.0 0.9476637886917731 33 P00374,P43490,Q9H2D1,P78417,O00764 5 Termination of translesion dna synthesis 0.4212858176999485 0.7507297099143495 0.4528153390926046 1.0 0.9498752304018911 16 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,P35244,P15927 8 Processive synthesis on the lagging strand 0.4442877309318835 0.735574061150925 0.4619899530540423 1.0 0.9647053271470954 11 P28340,P27694,P12004,P09884,P35244,P15927 6 Dna strand elongation 0.3735803775751219 0.735571777946467 0.461991342986018 1.0 0.9647053271470954 25 P49736,P28340,P27694,P49643,P33992,P12004,P40938,P33993,P09884,Q14566,P35244,P15927 12 Fgfr2 alternative splicing 0.4216871128350987 0.7314075083436749 0.4645302804697135 1.0 0.9670675838869492 15 O43251,O15514,P30876 3 Transcriptional regulation by mecp2 0.4375321278715032 0.7269647172952282 0.4672475699316933 1.0 0.969785741821974 12 Q14739,P42858 2 Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.406103021905257 0.7141826431200532 0.475114248171002 1.0 0.970762696648788 18 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,Q92890,P35244,P15927 9 Beta catenin independent wnt signaling 0.3602969922152182 0.7105175857102762 0.4773832296167177 1.0 0.970762696648788 46 Q9HCE1,P60900,P49720,P28070,Q96CW1,P28074,P25788,P20618,P07737,P49721 10 Regulation of pten stability and activity 0.3701622262717767 0.7094909628963771 0.4780198575950229 1.0 0.970762696648788 38 P60900,P49720,P49721,P28070 4 Unblocking of nmda receptors glutamate binding and activation 0.5842181380241604 0.7086390523776539 0.478548495409228 1.0 0.970762696648788 4 Q15334 1 Ras activation upon ca2 influx through nmda receptor 0.5842181380241604 0.7086390523776539 0.478548495409228 1.0 0.970762696648788 4 Q15334 1 Ptk6 regulates proteins involved in rna processing 0.7379927128188193 0.702881224615848 0.4821297727876801 1.0 0.970762696648788 2 Q07666 1 Ra biosynthesis pathway 0.5823319487607321 0.7017057136393073 0.4828627090660689 1.0 0.970762696648788 4 Q9BTZ2 1 Regulation of runx1 expression and activity 0.5812329344190847 0.6976735896502134 0.485381348324394 1.0 0.970762696648788 4 Q9HCE1 1 Disorders of transmembrane transporters 0.3287653774559087 0.692718000318607 0.4884865405423757 1.0 0.9718034285794568 70 P35613,P60900,P49720,P28070,P28074,P20618,Q9GZP9,P49721,Q9BTX1,A8CG34,P53985 11 Activation of bh3 only proteins 0.4746533429812733 0.6913720784891491 0.4893317461091657 1.0 0.9718034285794568 8 P63167,Q96FJ2,Q04917 3 Alpha oxidation of phytanate 0.5767008184288649 0.6811072316947131 0.4958036415096063 1.0 0.9718034285794568 4 P51648 1 Transcriptional regulation of white adipocyte differentiation 0.417580525128105 0.6503326277271809 0.515477385717273 1.0 0.9953821956919824 13 P11802,Q15648,Q09472 3 Diseases of mismatch repair mmr 0.7219743964284553 0.6482810484840906 0.5168031892560299 1.0 0.9953821956919824 3 P52701 1 Synthesis of ip2 ip and ins in the cytosol 0.7204372308711551 0.6419438884784698 0.5209096163957856 1.0 0.9953821956919824 2 Q01968 1 Microrna mirna biogenesis 0.4439169810186576 0.6385215699766168 0.5231342175243745 1.0 0.9953821956919824 9 O15514,P30876,P62826 3 Dna replication pre initiation 0.3265547041637411 0.6380014371949911 0.5234727445388025 1.0 0.9953821956919824 57 P62191,P49720,O43242,P27694,P49643,Q7L590,Q07864,O43913,P60900,P28070,O00487,P25787,P20618,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P49736,P51665,Q9NRF9,Q9UL46,P28074,P25788,Q14566,P62333,Q9Y619 29 Phosphorylation of emi1 0.7180251822398915 0.6357453089011343 0.5249424395068165 1.0 0.9953821956919824 3 P06493,P14635 2 Cristae formation 0.3826347533444976 0.6335373437337805 0.5263828023728441 1.0 0.9953821956919824 20 P00846,O75964,Q9Y512,Q13505 4 Intracellular signaling by second messengers 0.3336071549744683 0.6318183467152909 0.5275055837031326 1.0 0.9953821956919824 80 Q9HCE1,P60900,P49720,O43242,P28070,P28074,Q13362,P42345,P25788,P20618,Q8TBX8,P49721,O15111,O43865 14 Runx1 regulates transcription of genes involved in differentiation of hscs 0.3598923018882953 0.6247319324782775 0.5321470114298172 1.0 0.9976053096397208 37 P60900,P49720,P49721,P28070 4 Metabolism of ingested semet sec mesec into h2se 0.7148062272275647 0.6227905887782619 0.5334221436285067 1.0 0.9985313696806108 2 P32929 1 Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.4778455980167354 0.6158240886430709 0.5380106271263663 1.0 1.0 6 P09429,O15111,P05067 3 Negative regulation of nmda receptor mediated neuronal transmission 0.4973844448257393 0.6123092133165995 0.5403331950946355 1.0 1.0 5 Q15334 1 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.4968197657608725 0.6101325366458905 0.5417740149496522 1.0 1.0 5 P09884,P49643,P30153 3 Enos activation 0.7095762122098569 0.6091909187794091 0.5423978989432485 1.0 1.0 3 P35270 1 Insulin receptor recycling 0.4365872411640657 0.605231634691708 0.545025099075743 1.0 1.0 9 Q93050,P21281 2 Fceri mediated nf kb activation 0.3527667395296263 0.6008948581854326 0.5479100181260819 1.0 1.0 42 P60900,P49720,P49721,P28070 4 Metabolism of lipids 0.4138679763021898 0.5983393783292843 0.549613506520787 1.0 1.0 174 Q9BWD1,O00443,P09960,Q15165,P35790,Q8NCC3,Q9NZ01,Q9NPH0,Q16850,P10619,Q14739,O95864,P62826,P38435,Q09472,P16278,P48739,O43681,Q96G23,Q9Y5P4,Q9Y217,P51648,Q8IV08,P50897,P48651,Q15800,Q99943,P23786,Q86X55,P49748,Q9Y6X9,O00154,Q13510,P07602,Q15648,Q14534,Q15436,P04062,Q96N66,Q9NZJ7,O95470,Q8TBX8,Q15392,Q16880,Q16739,O43772,Q8WUK0 47 Signaling by notch1 0.453231888800966 0.5980618604719652 0.5497986575630409 1.0 1.0 8 Q96J02,Q09472 2 Notch3 activation and transmission of signal to the nucleus 0.7011174629937037 0.5829857279239811 0.5599029080039777 1.0 1.0 3 Q9Y6A5 1 Platelet calcium homeostasis 0.5489802275148432 0.5821811728501063 0.5604446534923837 1.0 1.0 4 P16615 1 Reduction of cytosolic ca levels 0.5489802275148432 0.5821811728501063 0.5604446534923837 1.0 1.0 4 P16615 1 Ros and rns production in phagocytes 0.4491655502114321 0.580687633869353 0.5614509975932134 1.0 1.0 8 Q93050,P21281 2 Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.3678932076550311 0.5757007524187899 0.5648174666910815 1.0 1.0 21 Q9NRF9,Q86W56,Q9UGN5,P28340,P12004,Q07864,P40938,P35244,P15927 9 Diseases of metabolism 0.344526960922194 0.5643722025382631 0.5725008525899578 1.0 1.0 45 P10253,P16278,P54802,O43826,P08236,P10619,Q8NCH0,P48507,Q9Y223 9 Fc epsilon receptor fceri signaling 0.3356252783780937 0.5609707289483352 0.5748174916985072 1.0 1.0 50 P60900,P49720,P28070,P20618,P49721 5 Apc cdc20 mediated degradation of nek2a 0.4041062938495458 0.5585748660723214 0.5764518972136776 1.0 1.0 12 P30260,Q13257,Q13042,O43684 4 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.4041062938495458 0.5585748660723214 0.5764518972136776 1.0 1.0 12 P30260,Q13257,Q13042,O43684 4 Notch4 activation and transmission of signal to the nucleus 0.6919509771447567 0.547240720294544 0.5842133640128508 1.0 1.0 2 Q92542 1 Signaling by notch 0.3219604714125189 0.5402937941952304 0.5889944374509999 1.0 1.0 55 Q96J02,Q9HCE1,Q09472,Q9Y6A5,O43242,P49720,P28070,P60900,P28074,P25788,P20618,P15291,Q92542,P49721 14 Late endosomal microautophagy 0.421731561362322 0.5389922171762661 0.5898922247776932 1.0 1.0 9 Q8WUX9 1 Egr2 and sox10 mediated initiation of schwann cell myelination 0.456971134621487 0.5328464680253746 0.594139864216912 1.0 1.0 6 Q9NR77 1 G alpha i signalling events 0.3490357103614332 0.529163565288962 0.5966919891162106 1.0 1.0 23 P07602,P05067,O43865 3 Dna damage bypass 0.3650163636760336 0.5269321715188247 0.5982406918295391 1.0 1.0 20 Q9NRF9,P28340,P27694,P12004,Q07864,P40938,Q92890,P35244,P15927 9 Purine salvage 0.5309910507126188 0.520565109625767 0.6026697600334501 1.0 1.0 4 P00491,P07741,P55263 3 Activation of atr in response to replication stress 0.3634762617590181 0.5177752651905686 0.6046150779267565 1.0 1.0 20 Q7L590,O14757,O43913,Q14566,P40938,Q9Y619 6 Signaling by wnt 0.3201924048331235 0.5145447395014086 0.6068711891430083 1.0 1.0 78 Q9HCE1,Q13363,P49720,O43242,P60900,P28070,Q13362,Q09472,P28074,P20618,Q96CW1,Q9UBQ0,P07737,P25788,P49721 15 Transferrin endocytosis and recycling 0.4015557872964288 0.5091373177208702 0.610655975886095 1.0 1.0 10 Q93050,P21281 2 Signaling by interleukins 0.3402959296585311 0.5029459201082355 0.6150022947379421 1.0 1.0 99 Q13126,P60900,P49720,P28070,P09601,P20618,P49721,Q53EL6,P78417 9 Cytochrome p450 arranged by substrate type 0.6711746039929785 0.4936247536801373 0.6215712155670918 1.0 1.0 3 Q16850 1 Telomere c strand synthesis initiation 0.4648416722873824 0.490654248595442 0.6236710105756527 1.0 1.0 5 P09884,Q15554 2 Recognition of dna damage by pcna containing replication complex 0.3726154677254833 0.4822189649418343 0.6296504058701446 1.0 1.0 16 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 Gap filling dna repair synthesis and ligation in gg ner 0.3690168016359584 0.4799445644475821 0.631266811841112 1.0 1.0 17 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 Rhov gtpase cycle 0.3873249952676448 0.4775409268032636 0.6329769846590874 1.0 1.0 12 O43396 1 Activation of bad and translocation to mitochondria 0.4605437665782397 0.4752348158319447 0.6346196141691738 1.0 1.0 5 P62258,P31946,P63104,Q04917 4 Nod1 2 signaling pathway 0.4398219071142427 0.467305906340742 0.6402810313283132 1.0 1.0 6 Q96J02,O15111,Q13685 3 Tryptophan catabolism 0.6654521364690373 0.4646232262438037 0.6422012964391492 1.0 1.0 2 Q6YP21 1 Formation of incision complex in gg ner 0.3702631914010634 0.4559085478715871 0.6484557425159643 1.0 1.0 15 P18074,Q9UGN5,P32780,Q86WJ1,P19447,P61088,P35244,P15927 8 Rhou gtpase cycle 0.3735841717310945 0.450469225040419 0.6523721397487696 1.0 1.0 14 O43396 1 Homology directed repair 0.335679590520393 0.4407193144968698 0.6594162120602276 1.0 1.0 34 Q9UQ84,Q9NRF9,P28340,Q9UGN5,O14757,Q13315,P12004,Q07864,P40938,Q9UNS1,P15927 11 Metabolism of vitamins and cofactors 0.3332086146298855 0.4403412222714777 0.6596899889030383 1.0 1.0 41 P00374,P43490,P35270,Q9H2D1,Q9NRN7,P78417,O00764 7 Long term potentiation 0.4505032930152981 0.4398887417657232 0.6600176902685932 1.0 1.0 5 Q15334 1 Class b 2 secretin family receptors 0.6555150712156427 0.4351940595289473 0.6634215741419203 1.0 1.0 2 P63218 1 Met activates pi3k akt signaling 0.6528651871480706 0.4274998389409532 0.6690153024119574 1.0 1.0 2 P62993 1 Response of eif2ak1 hri to heme deficiency 0.6471172962226603 0.4262108485041319 0.6699542131672003 1.0 1.0 3 P05198,P08243 2 Ire1alpha activates chaperones 0.327050427619065 0.4257210936390387 0.6703110897892415 1.0 1.0 24 O14773,P49748,O95070 3 Cardiac conduction 0.3777237593201781 0.4169362901138186 0.6767250084901104 1.0 1.0 11 P05026,O43865,P23634,P16615 4 Ion homeostasis 0.3777237593201781 0.4169362901138186 0.6767250084901104 1.0 1.0 11 P05026,O43865,P23634,P16615 4 G2 m checkpoints 0.3075759001812668 0.4080569326493541 0.6832318775073154 1.0 1.0 76 Q9UQ84,P60900,P49720,P28070,P28074,Q7L590,P20618,P25788,O14757,Q13315,P49721,O43913,P40938,Q14566,Q9Y619 15 Signaling by insulin receptor 0.3648444253416314 0.4077474008130715 0.6834591335914673 1.0 1.0 14 Q93050,P21281 2 Diseases of immune system 0.6401171716410023 0.4074173615923366 0.6837014776492771 1.0 1.0 3 P09429 1 Noncanonical activation of notch3 0.6455780059622478 0.4066855204396848 0.6842389765295349 1.0 1.0 2 Q92542 1 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.2944049048121207 0.4041243508096088 0.6861212792505822 1.0 1.0 64 O14949,Q9Y6M9,Q86Y39,P03886,P00403,P00846,O75964,Q9UDW1 8 Coenzyme a biosynthesis 0.6439218284200154 0.4020268579544018 0.6876642602749423 1.0 1.0 2 Q9NVE7 1 Global genome nucleotide excision repair gg ner 0.3284622693341888 0.3911175320958018 0.6957103620468812 1.0 1.0 37 P35244,Q7L5N1,P18074,Q9NRF9,Q9BT78,P28340,Q9UGN5,Q92905,Q99627,Q86WJ1,P12004,Q07864,P19447,P61088,P40938,P32780,P15927,P61201 18 Pcna dependent long patch base excision repair 0.3517512734554818 0.3885370151541522 0.6976186672200997 1.0 1.0 17 Q9NRF9,P28340,P12004,Q07864,P40938,P35244,P15927 7 Fcgamma receptor fcgr dependent phagocytosis 0.3250973301555281 0.3773323195707071 0.705926656723808 1.0 1.0 30 Q8IV08,Q9UQB8 2 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.3197903924230971 0.3748286522163973 0.7077879038404618 1.0 1.0 46 P15880,Q13347,P20042,P46782,P62753,Q15056,O15372,P62701,P62244,P62266,Q9Y262,O75821,P62241,P05198,P62841,P62280,P62249,P23396,P46781,P08708,P62847,P62277,O00303,P46783,O75822,Q14240 26 Dna replication 0.3103676479699691 0.3740946718363482 0.7083338826463685 1.0 1.0 82 P62191,P49720,O43242,P27694,P49643,Q7L590,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 37 Formation of atp by chemiosmotic coupling 0.3667723341419758 0.3689738566625966 0.7121472113790153 1.0 1.0 11 P00846 1 Estrogen dependent gene expression 0.321891644823189 0.3657993982419544 0.7145147689399638 1.0 1.0 28 Q9HCE1,Q15648,Q09472,Q99873,O15514,Q86X55,P30876 7 Hemostasis 0.3510192955552744 0.3592001520517204 0.7194453628858464 1.0 1.0 126 P07602,Q9BVA1,Q13362,P04350,P42785,Q8NBX0,Q9NZJ7,Q9BUF5,Q13356,P05067,Q13509,P68371,Q13885 13 Trna modification in the nucleus and cytosol 0.3664329877380248 0.3559088831743349 0.721908803027494 1.0 1.0 10 Q96PZ0,Q9NPF4,Q08J23 3 Pi3k akt signaling in cancer 0.4062457148528227 0.3496201048757947 0.7266238205533218 1.0 1.0 7 P63000,O15111,P42345,P62993 4 Rhod gtpase cycle 0.3188979562666427 0.3465319970807984 0.7289429418645448 1.0 1.0 28 Q9Y6M7,Q8TAA9,Q14739,P49257,O15173 5 Rhobtb2 gtpase cycle 0.3404428304406504 0.3457924462241753 0.7294987024150157 1.0 1.0 18 P78371 1 Mrna capping 0.3517194574417602 0.3301766743030019 0.7412664706684697 1.0 1.0 13 P32780,P30876 2 Ephrin signaling 0.4686012510879231 0.3279629033663929 0.7429397115106449 1.0 1.0 4 O00560 1 Formation of the early elongation complex 0.3370212808900421 0.3030524019564047 0.7618499271168104 1.0 1.0 16 P18615,O15514,P32780,P19447,P30876 5 Cd28 dependent vav1 pathway 0.4580709313887847 0.2993973493788363 0.7646368843591702 1.0 1.0 4 P63000,P62993,P60953 3 Signaling by fgfr2 iiia tm 0.3909699875392524 0.2982221877085286 0.765533588490249 1.0 1.0 7 P30876 1 Fgfr2 mutant receptor activation 0.3909699875392524 0.2982221877085286 0.765533588490249 1.0 1.0 7 P30876 1 Ripk1 mediated regulated necrosis 0.3501491911704114 0.2907049779216008 0.7712769641202846 1.0 1.0 10 O00560,Q8WUM4 2 Pi5p regulates tp53 acetylation 0.4544581017736688 0.2898976789375816 0.7718945173580263 1.0 1.0 4 Q8TBX8 1 Diseases of mitotic cell cycle 0.3359649174675828 0.2894970814931343 0.772201012957852 1.0 1.0 15 P11802,P30260,Q13042,Q00534,Q13309 5 Class i mhc mediated antigen processing presentation 0.3192100678103114 0.2768784673970406 0.7818734269939358 1.0 1.0 101 Q96J02,P49720,O43242,Q8TBC4,Q13042,P60900,P28070,P30260,P20618,P19474,P49721,O94822,Q9UIQ6,O15111,Q15345,P09429,Q9NZ08,Q15436,P28074,P25788,Q15386,P52888 22 Visual phototransduction 0.3837620231417714 0.2750833147293424 0.7832522301810327 1.0 1.0 7 P49356 1 Regulation of beta cell development 0.5849323340176591 0.2741391417497273 0.7839776948267025 1.0 1.0 3 Q09472 1 Diseases associated with glycosaminoglycan metabolism 0.3961032530996142 0.2680713179440255 0.7886444230315404 1.0 1.0 5 Q8NCH0 1 Piwi interacting rna pirna biogenesis 0.3787857107400904 0.2595507572564224 0.7952103247334104 1.0 1.0 7 P30876 1 Erks are inactivated 0.3782735318775416 0.2579731343249638 0.7964276413220217 1.0 1.0 7 Q8IV63,P27361,P30153 3 P75ntr regulates axonogenesis 0.5770702044372241 0.2574995780455029 0.7967931409962785 1.0 1.0 3 Q9NQC3 1 Raf independent mapk1 3 activation 0.3772768356709639 0.2557520607683827 0.7981422929393525 1.0 1.0 6 Q99956,P06493 2 E3 ubiquitin ligases ubiquitinate target proteins 0.3217551774760639 0.2527753214716886 0.8004418391308301 1.0 1.0 18 O75150,Q14527,Q9BUN8,P12004,P50542 5 Translesion synthesis by polk 0.3394417884871283 0.25027210440061 0.8023769276015762 1.0 1.0 10 P12004,P35244,P15927,P40938 4 Signaling by notch1 pest domain mutants in cancer 0.3751903497903011 0.2485606170505947 0.8037006755395173 1.0 1.0 7 Q09472 1 Activation of anterior hox genes in hindbrain development during early embryogenesis 0.3241578311212698 0.2437526912962673 0.8074223621235754 1.0 1.0 16 P30876,Q09472,P49711 3 S phase 0.3007241545928803 0.2426175413483682 0.8083016911356173 1.0 1.0 86 P62191,P49720,O43242,P11802,P27694,P49643,Q13042,Q07864,Q13309,O43913,Q13616,P60900,P28070,O00487,P30260,P20618,P25787,P33992,P49721,P09884,P35244,P15927,O75832,P25786,P40938,P49736,P51665,Q9NRF9,Q9UJX4,Q9UL46,P28340,P28074,P25788,P12004,Q14566,P62333,Q9Y619 37 Wnt ligand biogenesis and trafficking 0.4320049605734612 0.2344889248338223 0.8146054302470256 1.0 1.0 4 Q9UBQ0 1 Advanced glycosylation endproduct receptor signaling 0.3571463303101402 0.2330732248576508 0.8157045458559244 1.0 1.0 8 P47755,P09429,P05067 3 Translesion synthesis by polh 0.3306831361362822 0.2317306151711109 0.8167472510637399 1.0 1.0 12 P12004,P40938,Q92890,P35244,P15927 5 Lagging strand synthesis 0.3172543006228184 0.2212362733945835 0.8249084668571429 1.0 1.0 17 P28340,P27694,P12004,P40938,P09884,P35244,P15927 7 Metabolism of carbohydrates 0.3063884213337545 0.2211329908707456 0.8249888830459531 1.0 1.0 94 P10253,Q9UBX3,P16278,Q8TB61,P54802,O43826,Q9BTX1,P08236,Q9BRR6,Q8NCH0,Q7LGA3 11 Neutrophil degranulation 0.3655544275506028 0.2119068661104782 0.8321796938589752 1.0 1.0 162 P63167,P30519,P09960,P42785,Q14019,P08236,P10619,P68371,Q9BXS5,P16278,P04066,P20618,P07437,O43681,Q93050,Q9BTY2,P78371,P09429,O00560,Q4KMQ2,O15260,Q13510,P10253,P07602,Q9NZJ7,P15586,O00764 27 P75 ntr receptor mediated signalling 0.3231702200399796 0.2111254809600667 0.83278935741398 1.0 1.0 13 P63000,Q92542,Q9NQC3,Q9H8V3,P52565 5 Rna polymerase iii transcription initiation from type 1 promoter 0.3280135971456215 0.2094834065610284 0.8340708876752094 1.0 1.0 10 Q969F1,O14802 2 Sars cov infections 0.2897507122128233 0.2055798677159815 0.8371191048518334 1.0 1.0 52 Q8WUX9,P07437,Q99720,Q99873 4 Rho gtpases activate cit 0.3267780996055646 0.2052283421407574 0.8373937268742009 1.0 1.0 10 Q15334,P63000,P60660,Q15058 4 Signaling by vegf 0.2984771056778997 0.2018438749393468 0.840038780157994 1.0 1.0 22 O43865,Q9UQB8 2 Transport of vitamins nucleosides and related molecules 0.3579203921685875 0.1986146805225948 0.8425641690007606 1.0 1.0 7 Q8TB61 1 Pp2a mediated dephosphorylation of key metabolic factors 0.545533485177593 0.1971684039318013 0.8436957552601769 1.0 1.0 3 P30153 1 Signaling by fgfr2 in disease 0.3319023033039641 0.1934008180322335 0.8466450748323042 1.0 1.0 9 P30876 1 Neurexins and neuroligins 0.3422093697650473 0.1879880363085092 0.8508860296267364 1.0 1.0 8 Q15334 1 Mastl facilitates mitotic progression 0.3649283779404519 0.1878434358157388 0.8509993849344935 1.0 1.0 5 P30153,P14635,P06493 3 Recycling of eif2 gdp 0.3509650973234269 0.1798901230065893 0.8572388294094218 1.0 1.0 7 Q9NR50,Q14232,Q13144,P05198,P49770 5 Abortive elongation of hiv 1 transcript in the absence of tat 0.3160192669288543 0.1774808564701704 0.85913070085223 1.0 1.0 12 P18615,O15514,P30876 3 Synthesis of udp n acetyl glucosamine 0.3601529491275274 0.1768945557331663 0.8595912150806113 1.0 1.0 5 Q9UJ70 1 Transcriptional regulation by runx1 0.2706008659915087 0.1765542504750017 0.8598585322672583 1.0 1.0 64 Q96J02,Q9HCE1,Q09472,P49720,P28070,P60900,Q99873,P28074,P25788,P20618,Q16625,Q00534,P49721 13 Constitutive signaling by overexpressed erbb2 0.4032614807970777 0.1732532056811716 0.86245240383325 1.0 1.0 4 P07900 1 Suppression of apoptosis 0.4030171559710731 0.1727813236670508 0.8628233177983342 1.0 1.0 4 P23246,P14373 2 Met activates ptpn11 0.5307945788355264 0.1725884459882111 0.8629749343748054 1.0 1.0 3 P62993 1 Base excision repair 0.2899095588404833 0.1606558952049275 0.8723644286244312 1.0 1.0 30 Q96T60,Q9NRF9,P28340,Q9UGN5,P12004,P40938,P29372,Q15554,P15927 9 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.3944315545243506 0.156729197376174 0.8754582752658993 1.0 1.0 4 Q14738,P30153,P30154 3 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.3400085824160395 0.1565931818679384 0.8755654763319205 1.0 1.0 6 Q9UKZ1 1 Irak1 recruits ikk complex 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 Ikk complex recruitment mediated by rip1 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 Ticam1 rip1 mediated ikk complex recruitment 0.518663828495631 0.1541077442365636 0.8775247822091317 1.0 1.0 3 O15111 1 Downregulation of smad2 3 smad4 transcriptional activity 0.3478116710875368 0.1503214431725288 0.8805110160025145 1.0 1.0 5 Q93008,P09874,Q9UPN9,Q13547 4 Irs mediated signalling 0.5102717031146418 0.1422442444420197 0.8868870850620827 1.0 1.0 3 Q99570,P62993 2 Frs mediated fgfr3 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr2 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Tie2 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Frs mediated fgfr1 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr3 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr1 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Frs mediated fgfr2 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Frs mediated fgfr4 signaling 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr4 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Stat5 activation downstream of flt3 itd mutants 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Stat5 activation 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Activated ntrk2 signals through frs2 and frs3 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Signaling by flt3 itd and tkd mutants 0.5101026830076325 0.1283328351488747 0.8978855812442654 1.0 1.0 2 P62993 1 Cyclin d associated events in g1 0.3018691720118506 0.1273641298180887 0.8986522052454764 1.0 1.0 11 Q13616,P11802,Q00534,Q13309,P30153 5 G beta gamma signalling through cdc42 0.5084465054653999 0.1262933294702367 0.899499736293581 1.0 1.0 2 P63218 1 Polymerase switching 0.2999083193806568 0.1234400041664036 0.9017586805446204 1.0 1.0 12 P09884,P12004,P40938,P28340 4 N glycan antennae elongation in the medial trans golgi 0.4902889478628819 0.1169858639721942 0.9068712554745147 1.0 1.0 3 P04066 1 Nervous system development 0.3776066495452238 0.1076888822682559 0.9142424888883656 1.0 1.0 194 Q9Y3U8,P49720,O43242,Q9BVA1,P07900,P32969,P39023,Q01518,Q16850,Q15334,O15145,P60660,Q9BPU6,P68371,P46776,Q13885,O14786,P60900,P28070,P50552,P27635,Q12955,P18621,P04350,Q7Z460,P20618,Q96CW1,P46782,P07737,Q9NR77,P49721,Q92542,Q02543,P62701,P62244,P62917,P83731,P62266,P46779,Q02878,Q9BUF5,P61313,P62241,P62841,P46778,O00560,Q13509,P18077,Q13617,P28074,P61254,P25788,P08708,Q96S59,P83881 55 P75ntr negatively regulates cell cycle via sc1 0.4898973169923965 0.10558674128321 0.9159102448644754 1.0 1.0 2 Q13547 1 Pten regulation 0.2591210234965989 0.104180204168575 0.9170263432631672 1.0 1.0 61 Q9HCE1,P60900,P49720,O43242,P28070,P42345,P28074,P25788,P20618,P49721 10 Regulation of tp53 activity through methylation 0.3175691297461373 0.1018938233227505 0.9188409527203778 1.0 1.0 7 Q09472 1 Rhoq gtpase cycle 0.2825845350143573 0.0995085997591814 0.9207344601706248 1.0 1.0 20 Q9Y6M7,Q15642,Q68EM7,Q8TAA9 4 Rac3 gtpase cycle 0.2792539668588933 0.0927449036225325 0.9261062227891984 1.0 1.0 32 Q8TAA9,Q9UQB8,Q14739,P49257,O15173 5 Respiratory electron transport 0.2731275853303941 0.0917936999030121 0.9268619496787224 1.0 1.0 53 O75880,Q9Y6M9,Q86Y39,P03886,P00403,O14949,Q9UDW1 7 Cell surface interactions at the vascular wall 0.2852802633494709 0.0908715808127838 0.9275946319664856 1.0 1.0 17 P35613,Q9UPY5,Q13356,Q92896,P53985 5 Bile acid and bile salt metabolism 0.3137308256114017 0.0900547791062246 0.9282436841908828 1.0 1.0 5 P22059 1 Synthesis of bile acids and bile salts 0.3137308256114017 0.0900547791062246 0.9282436841908828 1.0 1.0 5 P22059 1 Regulation of localization of foxo transcription factors 0.4602385685884633 0.0866045433125212 0.9309858544312192 1.0 1.0 3 P31946,P63104 2 Mitotic spindle checkpoint 0.2750244449323438 0.0860958244060395 0.9313902429422928 1.0 1.0 51 P63167,Q13362,Q7Z460,Q13042,P43034,Q13257,Q9P258 7 Wax and plasmalogen biosynthesis 0.3463705667881979 0.0858335086637746 0.9315987687025276 1.0 1.0 4 Q6IAN0,O00116,Q8WVX9 3 Pentose phosphate pathway 0.3048092868988342 0.0851742497188798 0.9321228619208866 1.0 1.0 6 P52209,Q96G03,P11413,P29401,O95336 5 Aflatoxin activation and detoxification 0.4624047697913376 0.0816543738883752 0.9349215615036572 1.0 1.0 2 O14880 1 Amino acid transport across the plasma membrane 0.3410672853828277 0.07992326259649 0.9362982881336646 1.0 1.0 4 Q9H2H9,P08195,Q9UPY5 3 Miro gtpase cycle 0.2960875331565011 0.0663176540885294 0.9471249282347254 1.0 1.0 5 O95140,Q8IWA4,P52306,Q8IXI1 4 M phase 0.3611035325825698 0.063455579245693 0.9494037305446889 1.0 1.0 178 Q9H6D7,P60900,P49720,P28070,Q9BVA1,Q13362,P04350,Q7Z460,Q86XL3,Q9BUF5,P07437,P49721,Q9BTX1,Q8WUX9,Q13509,P68371,Q13885 17 Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0.426495293051693 0.062312675839974 0.9503138342338812 1.0 1.0 3 O14786 1 Processing of dna double strand break ends 0.2680415270631722 0.0604265981088138 0.9518158751314454 1.0 1.0 22 Q9UQ84,O14757,Q13315,P40938,Q9UNS1,P15927 6 Zbp1 dai mediated induction of type i ifns 0.3191912495856762 0.0592391478995165 0.95276162886241 1.0 1.0 4 Q08211,Q9NZI8,O15111 3 Rip mediated nfkb activation via zbp1 0.319191249585676 0.0592391478995165 0.95276162886241 1.0 1.0 4 Q08211,O15111,Q9NZI8 3 Inositol phosphate metabolism 0.2871352785145901 0.0561233339385807 0.9552435554370162 1.0 1.0 5 Q01968,Q9BW91,Q9NPH2,Q9UNW1 4 Signaling by erbb2 ecd mutants 0.2871352785145883 0.0561233339385788 0.9552435554370178 1.0 1.0 5 P62993,Q96RT1,P07900,Q16543 4 Signaling by erbb2 in cancer 0.2871352785145883 0.0561233339385788 0.9552435554370178 1.0 1.0 5 P62993,Q96RT1,P07900,Q16543 4 Nucleotide salvage 0.2883211678832167 0.0503782226168225 0.959820990180648 1.0 1.0 7 Q9BZX2,P00491,P00492,P07741,P55263,Q08623 6 Tp53 regulates transcription of death receptors and ligands 0.394501490559802 0.0498388196655772 0.960250831486906 1.0 1.0 2 P49327 1 Oas antiviral response 0.393969516235911 0.0470658698564479 0.9624607290866314 1.0 1.0 3 P61221,Q6L8Q7 2 Protein ubiquitination 0.2628524335738891 0.0426984142065389 0.965941943698344 1.0 1.0 27 O75150,Q14527,Q9BUN8,P12004,P50542,P61088 6 Glycerophospholipid catabolism 0.3256045048029257 0.040641975142977 0.9675813204596306 1.0 1.0 2 Q8N9F7 1 Polb dependent long patch base excision repair 0.2813727423686923 0.0404245089626096 0.9677546908896596 1.0 1.0 7 Q9UGN5,P27695,P09874,Q86W56 4 Synthesis of ip3 and ip4 in the cytosol 0.2868499503146861 0.0394562234305353 0.9685266549591712 1.0 1.0 2 Q01968 1 Signaling by retinoic acid 0.2681787047191667 0.0358333155023457 0.9714152681880248 1.0 1.0 12 Q9BTZ2,O00330,Q15120,Q9HBH5 4 Signaling by ptk6 0.2673506149120848 0.0349339138108509 0.9721324377986782 1.0 1.0 9 P11802,P63000,Q07666 3 Tight junction interactions 0.3343273691186175 0.0335363916426276 0.9732468458095058 1.0 1.0 3 Q8NI35,Q8N3R9 2 Rna polymerase iii chain elongation 0.275107722903538 0.0331675328424117 0.9735409889086092 1.0 1.0 4 O14802,Q9BUI4,P62875 3 Rna polymerase iii transcription initiation from type 3 promoter 0.275107722903538 0.0331675328424117 0.9735409889086092 1.0 1.0 4 O14802,Q9BUI4,P62875 3 Displacement of dna glycosylase by apex1 0.3207422133863425 0.0321391535934674 0.9743610794742912 1.0 1.0 3 P27695,P29372 2 Regulation of bach1 activity 0.2887274277090861 0.0302202027243674 0.975891436444817 1.0 1.0 3 Q13309 1 Pyrimidine salvage 0.2879390324718301 0.0301907611396797 0.9759149167168792 1.0 1.0 3 Q9BZX2,Q08623 2 Dap12 interactions 0.2869449966865412 0.0301545833642398 0.9759437692688162 1.0 1.0 3 P63000,P62993 2 Dap12 signaling 0.2869449966865412 0.0301545833642398 0.9759437692688162 1.0 1.0 3 P63000,P62993 2 Signaling by fgfr 0.2560151083555537 0.0232116051821363 0.98148148150561 1.0 1.0 23 O43251,O15514,P30876 3 Signaling by fgfr2 0.2560151083555537 0.0232116051821363 0.98148148150561 1.0 1.0 23 O43251,O15514,P30876 3 Ksrp khsrp binds and destabilizes mrna 0.2624795885042132 0.0184933227271386 0.9852453043478586 1.0 1.0 14 Q9NQT4,Q15024,Q92945 3 Atf4 activates genes in response to endoplasmic reticulum stress 0.2594428533602185 0.0110104996406288 0.9912150698315034 1.0 1.0 14 Q9NQT4,Q15024,Q92945 3 Perk regulates gene expression 0.2602199510365197 0.0102372342173709 0.9918320115417308 1.0 1.0 16 Q9Y3B2,Q9NQT4,Q15024,Q8IU60,Q9Y2L1,P05198,Q92945,Q9NQT5,Q96B26,P08243 10 Semaphorin interactions 0.2590296042660046 0.008393395904603 0.9933031176266538 1.0 1.0 19 P60660,Q9BPU6,O14786,P07900 4 Signaling by erbb4 0.2501593059712398 0.0051321763886379 0.9959051336721374 1.0 1.0 8 Q96J02,Q15334 2 Trafficking of ampa receptors 0.2465843128702768 0.0013165346701444 0.9989495576163788 1.0 1.0 8 Q15334 1