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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:e729c681a6096ca46433b388efc4e999b4acc2f0c93258faeb7162260ea4b7b0
+size 69332

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 54,
+    "title": "Average number of proteins per term",
+    "value": 2.537037037037037
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C257/C257_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase S9, serine active site [IPR002471]	0.6105228325612251	0.2966274356725927	0.7667509624566318	1.0	0.9969071523154744	2	P13798	1
+Ubiquitin-conjugating enzyme, active site [IPR023313]	0.3413046884597043	0.1611711862193876	0.8719585744696146	1.0	0.9969071523154744	5	P61088	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.3745863666446166	0.0503328913534631	0.959857113468169	1.0	0.9969071523154744	2	Q9NQ88	1
+ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]	0.2817880794701939	0.0382461508437495	0.9694914247411076	1.0	0.9969071523154744	4	P06576,P21281,P25705	3

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "MTMR6", "MYLK", "NEK9", "NME1", "NME2", "NME3", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKCD", "PRKD3", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["APEH", "ATP5A1", "ATP5B", "ATP6V1B2", "TIGAR", "UBE2N"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:a0f9244f4b858fe27f6bbf00193cad0685e06f07429093cc785394fec1a4d34b
+size 66971

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.40625
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C257/C257_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M16, zinc-binding site [IPR001431]	0.4775257259242395	0.608022753883793	0.5431723827890993	0.9999999999870558	0.8276912499643417	5	O43847	1
+Beta tubulin, autoregulation binding site [IPR013838]	0.3632537350336424	0.2160647465161525	0.8289372788544696	1.0	1.0	6	P07437,P04350,Q13885	3
+EF-Hand 1, calcium-binding site [IPR018247]	0.4530511790747036	0.2020200809676463	0.8399010254934298	1.0	1.0	35	O95302,Q14257,Q9BPX6,P0DP25,P80303,Q9NZM3,O43852,Q02818,P19174	9
+Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]	0.2882197220383936	0.0447362818338146	0.9643175139147272	1.0	1.0	2	O15270	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PPM1L", "PRKCD", "PRKCSH", "PRKD3", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALM3", "CALU", "FKBP9", "ITSN2", "MICU1", "NRDC", "NUCB1", "NUCB2", "PLCG1", "RCN2", "SPTLC2", "TUBB", "TUBB2A", "TUBB4A"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "ABC transporter-like, conserved site [IPR017871]", "1": "FERM conserved site [IPR019747]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:a23e742f896955ee56aa342654009d63aff19ef4f88656f14f9e90d1db9f8a73
+size 70318

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 269,
+    "title": "Average number of proteins per term",
+    "value": 2.684014869888476
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C257/C257_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,32 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Haem oxygenase conserved site [IPR018207]	0.9854401058901392	1.583238085648166	0.113367208791594	0.9999999999999912	0.861683895981568	2	P30519	1
+Oxysterol-binding protein, conserved site [IPR018494]	0.687959466593157	1.5132845045186	0.1302074069973864	1.0	0.8737201209962339	5	Q9BZF3	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.6663316618598141	1.415277921268113	0.1569870258285748	1.0	0.8737201209962339	8	P20618,P28072,P28070,P49721	4
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.7596836516169699	1.253372115671365	0.2100703144964955	1.0	0.9742916310268498	3	Q9Y2T2	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.7262495862297293	1.1245845124990574	0.2607651396193511	1.0	0.9879693317972598	3	P26583,O15347	2
+Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]	0.5752681959154995	0.919390408567153	0.3578914043341137	1.0	0.9992746092261258	14	P07814	1
+Dynamin, GTPase region, conserved site [IPR019762]	0.7935142289874275	0.8565227613152068	0.3917086883486786	1.0	0.9992746092261258	2	O00429	1
+DnaJ domain, conserved site [IPR018253]	0.5438820571719358	0.8468848869808151	0.3970592870535023	1.0	0.9992746092261258	10	Q9NVH1,O60884,Q99543	3
+Intermediate filament protein, conserved site [IPR018039]	0.5316125925140122	0.8253598316444332	0.4091673326810345	1.0	0.9992746092261258	8	P08670	1
+Mini-chromosome maintenance, conserved site [IPR018525]	0.52283642780841	0.8189056871911491	0.4128402249031864	1.0	0.9992746092261258	6	Q14566	1
+14-3-3 protein, conserved site [IPR023409]	0.4778739884208312	0.6289697745868724	0.5293688443127806	1.0	0.9992746092261258	6	Q04917,P27348,P31946	3
+4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]	0.7266710787557946	0.6253687402566555	0.5317290736686087	1.0	0.9992746092261258	2	P61221	1
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.4833969633091155	0.622623809585075	0.5335317611533292	1.0	0.9992746092261258	8	P30837	1
+Chaperonin TCP-1, conserved site [IPR002194]	0.4643149143760369	0.5457341041308604	0.5852487253875791	1.0	0.9992746092261258	8	P49368,P50991	2
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.4446300047067765	0.4692037964534531	0.6389239720959357	1.0	0.9992746092261258	8	P30837	1
+Zinc finger, RING-type, conserved site [IPR017907]	0.4352893673439	0.3726998477462593	0.7093718497869927	1.0	0.9992746092261258	13	O75150,P19474	2
+Thioredoxin, conserved site [IPR017937]	0.4216982301815771	0.3488489699626887	0.7272026973030115	1.0	0.9992746092261258	11	O43396	1
+ABC transporter-like, conserved site [IPR017871]	0.404840848806365	0.3257971820253909	0.744577810932221	1.0	0.9992746092261258	8	Q8NE71,O75027,Q9UG63,P28288,P61221,Q9NUQ8,Q9NRK6	7
+Tubulin, conserved site [IPR017975]	0.3632537350336424	0.2160647465161525	0.8289372788544696	1.0	0.9992746092261258	6	P07437,P04350,Q13885	3
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.5661813368630133	0.2065987768589921	0.8363232155820084	1.0	0.9992746092261258	2	P11216	1
+Calreticulin/calnexin, conserved site [IPR018124]	0.4323071830519656	0.1893488280618039	0.8498194281686917	1.0	0.9992746092261258	3	P27824,O14967	2
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.3411725736999183	0.1608662207673825	0.8721987676769927	1.0	0.9992746092261258	5	Q9UBF8,P42356,P78527,P42345	4
+Clathrin adaptor complex, small chain [IPR000804]	0.5357379219060322	0.1579957679634329	0.8744601335075104	1.0	0.9992746092261258	2	P61923	1
+DNA-directed DNA polymerase, family B, conserved site [IPR017964]	0.5188616810059637	0.1356620320560858	0.8920884641901392	1.0	0.9992746092261258	2	P28340	1
+Tetraspanin, conserved site [IPR018503]	0.4616148246194684	0.082360463336892	0.934360074883328	1.0	0.9992746092261258	2	O43657	1
+FERM conserved site [IPR019747]	0.3136604774535843	0.0803906531706086	0.935926560534906	1.0	0.9992746092261258	8	P35241,Q9HCM4,Q9Y490,Q9Y2J2,P26038,P11171,P15311	7
+Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]	0.438451356717411	0.0692437830759004	0.9447955728645672	1.0	0.9992746092261258	2	Q6XZF7	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.2945497776825815	0.058132887581407	0.9536427781778204	1.0	0.9992746092261258	6	Q9P2W9	1
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.4037061548643369	0.0564201308717525	0.9550071203804362	1.0	0.9992746092261258	2	O60573	1
+Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]	0.2915287888815438	0.0447881618687046	0.9642761610850712	1.0	0.9992746092261258	2	P28482	1
+Ubiquitin specific protease, conserved site [IPR018200]	0.2973040863332304	0.0306630028923329	0.9755382966938202	1.0	0.9992746092261258	12	Q86UV5,Q96K76,Q9Y4E8	3

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Deoxyribonuclease, TatD-related, conserved site [IPR018228]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamine synthetase, N-terminal conserved site [IPR027302]", "Glutamine synthetase, glycine-rich site [IPR027303]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARIH2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FBXW11", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK2", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GLUL", "GMPPA", "GMPPB", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT1", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IQGAP3", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MIF", "MOCS1", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSD3", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAD18", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RCL1", "RDH13", "RDX", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE1", "SYNE2", "TATDN1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ALDH1B1", "AP3M1", "CANX", "CCT3", "CCT4", "CLGN", "COPZ1", "DNAJA2", "DNAJC11", "DNAJC2", "DNM1L", "DNMBP", "EIF4E2", "EPB41", "EPB41L3", "EPB41L5", "EPRS", "EZR", "HMGB2", "HMGB3", "HMOX2", "MAPK1", "MCM6", "MSN", "MTOR", "OSBPL6", "PI4KA", "PI4KB", "POLD1", "PRKDC", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PYGB", "RDX", "RNF40", "STX18", "TLN1", "TRIM21", "TSPAN6", "TUBB", "TUBB2A", "TUBB4A", "TXNL1", "USP15", "USP47", "USP48", "VIM", "YWHAB", "YWHAH", "YWHAQ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "DnaJ domain [IPR001623]", "1": "Importin-beta, N-terminal domain [IPR001494]", "2": "Pleckstrin homology domain [IPR001849]", "3": "ABC transporter-like, ATP-binding domain [IPR003439]", "4": "RecF/RecN/SMC, N-terminal [IPR003395]", "5": "MIF4G-like, type 3 [IPR003890]", "6": "FERM, N-terminal [IPR018979]", "7": "FERM, C-terminal PH-like domain [IPR018980]", "8": "FERM domain [IPR000299]", "9": "EF-hand domain [IPR002048]", "10": "K Homology domain, type 1 [IPR004088]", "11": "FERM central domain [IPR019748]", "12": "Band 4.1 domain [IPR019749]", "13": "Zinc finger, RING-type [IPR001841]", "14": "TGS [IPR004095]", "15": "Myosin head, motor domain [IPR001609]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:5b88f44696bf24ded4e38cdfb23f6dd7e88c831a71eb7e14ae4b360b33d9651e
+size 108330

interpro_domain/df_merge.tsv

@@ -0,0 +1,4 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	2	5	2.526452789898844	0.0115220873234873	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	1.0	0.0025659780541994	0.0007358710981923	0.0053637976870067
+Aminopeptidase N-like , N-terminal domain [IPR045357]	2	5	2.526452789898844	0.0115220873234873	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	1.0	0.0025659780541994	0.0007358710981923	0.0053637976870067
+Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]	0	6	2.0241934972396844	0.042950246406066	3.5825242718446604	6.451456310679611	-0.5441228758627483	0.4846961486603726	1.578214991720231	0.5574498240592337	0.8220009832135144	0.2991919816292875	0.0070422251257083	0.0385773062479974	0.0758460972151271	0.1795191310032965	0.3296279245345712

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 2581,
+    "title": "Average number of proteins per term",
+    "value": 2.143355288647811
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C257/C257_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,227 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.931595185122844	2.5264527898988436	0.0115220873234873	0.9999999999998976	0.7853295988111895	5	P55786,Q9UIQ6	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.931595185122844	2.5264527898988436	0.0115220873234873	0.9999999999998976	0.7853295988111895	5	P55786,Q9UIQ6	2
+ERAP1-like C-terminal domain [IPR024571]	0.9619331347236004	2.0264742750046985	0.0427162063142219	1.0	0.7853295988111895	3	P55786,Q9UIQ6	2
+Cyclic nucleotide-binding domain [IPR000595]	0.8863132196465904	1.989697119714534	0.0466243101842414	1.0	0.7853295988111895	4	Q9Y4G8	1
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.7846282334650512	1.9586571871407912	0.0501529474736592	1.0	0.7853295988111895	6	O15173,O43169,Q8WUJ1,Q9UMX5	4
+Zinc finger, CHHC-type [IPR012996]	0.9268454154253544	1.894790943540794	0.0581201035035732	1.0	0.7853295988111895	3	P31943,P55795	2
+Cold-shock protein, DNA-binding [IPR002059]	0.8474534664019572	1.8398040522964636	0.0657970102974898	1.0	0.7853295988111895	4	P67809	1
+Cold-shock (CSD) domain [IPR019844]	0.8474534664019572	1.8398040522964636	0.0657970102974898	1.0	0.7853295988111895	4	P67809	1
+Cold shock domain [IPR011129]	0.8474534664019572	1.8398040522964636	0.0657970102974898	1.0	0.7853295988111895	4	P67809	1
+Zinc finger, RanBP2-type [IPR001876]	0.7639924905342852	1.8193435406939864	0.0688590345494288	1.0	0.7853295988111895	9	Q92804,P35637	2
+Fibronectin type II domain [IPR000562]	0.8887827117664657	1.7504340360998385	0.0800434472245681	1.0	0.7853295988111895	3	Q9UBV2	1
+Gelsolin-like domain [IPR007123]	0.735346054251991	1.749337455210001	0.0802327051984086	1.0	0.7853295988111895	6	Q13045,O95425	2
+UBX domain [IPR001012]	0.7299613630356586	1.7262143051426344	0.0843088654192181	1.0	0.7853295988111895	6	Q9BZE9,Q9UNZ2,Q9UNN5	3
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.9847782925215092	1.580688006254224	0.113949392057282	1.0	0.7853295988111895	2	Q15629	1
+AGC-kinase, C-terminal [IPR000961]	0.6839306568155945	1.5093937083251838	0.1311981999677542	1.0	0.7957057817499716	7	Q05655,P51812,Q13464	3
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.962938451356718	1.496511538651217	0.1345204032996902	1.0	0.7999934583329508	2	Q14011	1
+SET domain [IPR001214]	0.6855528951200898	1.4820592503271317	0.1383245302517648	1.0	0.8051435688293119	9	Q9H7B4,Q9BZ95	2
+Exportin-1/Importin-beta-like [IPR013598]	0.7373240038130497	1.4056009156883322	0.1598426639934571	1.0	0.8051435688293119	4	Q9HAV4,Q9Y5L0	2
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.9315023163467906	1.3754273264774115	0.1689990019297642	1.0	0.8051435688293119	2	O60506	1
+Protein kinase, C-terminal [IPR017892]	0.6484437967592589	1.3711153472111215	0.1703390014776662	1.0	0.8051435688293119	6	Q05655,P51812	2
+GMP phosphodiesterase, delta subunit [IPR008015]	0.9285241561879568	1.3639723859103778	0.1725762568226225	1.0	0.8051435688293119	2	A6NIH7	1
+Mu homology domain [IPR028565]	0.7257820880575103	1.3595472263655293	0.1739732480390516	1.0	0.8051435688293119	4	Q9Y2T2	1
+Oxidoreductase, N-terminal domain [IPR041694]	0.9235605559232318	1.3448904664820047	0.1786606093937246	1.0	0.8051435688293119	2	Q8N8N7	1
+AP complex, mu/sigma subunit [IPR022775]	0.6478175415848554	1.3379957582301951	0.1808978195336279	1.0	0.8051435688293119	5	Q9Y2T2	1
+Prenylcysteine lyase [IPR010795]	0.919920582395766	1.3309055864986978	0.1832200788292821	1.0	0.8051435688293119	2	Q9UHG3	1
+RBM1CTR [IPR012604]	0.9060225016545354	1.2775887994397133	0.2013944518948434	1.0	0.8188969748847665	2	P38159	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.9053606882859044	1.275053523448848	0.2022902980930661	1.0	0.8188969748847665	2	Q96AE4	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.7649220002557754	1.2736054978576292	0.2028032628266136	1.0	0.8188969748847665	3	Q92688	1
+Dynamin, GTPase domain [IPR001401]	0.762992386626939	1.266151205544077	0.2054589529849415	1.0	0.8188969748847665	3	P50570,O00429	2
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.7583917711736803	1.248383674109638	0.2118905848348284	1.0	0.8318980550288956	3	A0FGR8	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.7580271433300174	1.2469758269738789	0.212406361202651	1.0	0.8318980550288956	3	Q06323,Q9UL46	2
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.7580271433300174	1.2469758269738789	0.212406361202651	1.0	0.8318980550288956	3	Q06323,Q9UL46	2
+Intermediate filament head, DNA-binding domain [IPR006821]	0.6958358864058121	1.2399116199390527	0.2150080854767666	1.0	0.8332370399632653	4	P08670	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.7500827540549351	1.21631698657187	0.2238641931361213	1.0	0.8451585277934341	3	Q5BKZ1,O43823	2
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.5997662806263003	1.1393761183821067	0.2545463123631726	1.0	0.850188644841012	7	Q8N8N7,Q8N4Q0	2
+GINS subunit, domain A [IPR021151]	0.8623428193249514	1.1112790068469636	0.2664482727518129	1.0	0.8582279299503048	2	Q9BRT9	1
+Exportin-2, central domain [IPR013713]	0.717819622981851	1.0922614850040515	0.2747181841019552	1.0	0.8595596426525444	3	O15397	1
+CBS domain [IPR000644]	0.6585139737283273	1.0910524527827	0.2752498029022301	1.0	0.8595596426525444	4	Q6P4Q7	1
+Heat shock chaperonin-binding [IPR006636]	0.6578541973421528	1.0884288496309251	0.2764058308884016	1.0	0.8595596426525444	4	P31948,P54725	2
+YTH domain [IPR007275]	0.8510919920582398	1.0688856640279305	0.2851211925200432	1.0	0.8638171946274236	2	Q96MU7	1
+NOPS [IPR012975]	0.7047335319430623	1.042259455968158	0.2972914042259562	1.0	0.8718653885120704	3	P23246,Q15233	2
+PITH domain [IPR010400]	0.8309066843150263	0.9934582019705286	0.3204867101732027	1.0	0.8849320590548422	2	O43396	1
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.6909748320852424	0.9899682891948264	0.322189618894565	1.0	0.8849320590548422	3	Q06787	1
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.6909748320852424	0.9899682891948264	0.322189618894565	1.0	0.8849320590548422	3	Q06787	1
+Fxr1, tudor domain [IPR041560]	0.6909748320852424	0.9899682891948264	0.322189618894565	1.0	0.8849320590548422	3	Q06787	1
+Agenet-like domain [IPR008395]	0.6909748320852424	0.9899682891948264	0.322189618894565	1.0	0.8849320590548422	3	Q06787	1
+Small acidic protein-like domain [IPR028124]	0.8266048974189318	0.977503947452707	0.328319724456358	1.0	0.8910548988663093	2	O00193	1
+Guanine nucleotide exchange factor, N-terminal [IPR032691]	0.8203176704169451	0.9542714070699247	0.3399462774688482	1.0	0.8954142649192239	2	Q7Z3U7	1
+FCP1 homology domain [IPR004274]	0.8199867637326286	0.9530515560188711	0.3405639494687238	1.0	0.8954142649192239	2	Q3ZCQ8	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.6759351208209206	0.933218249040584	0.3507072943027909	1.0	0.8979915938447454	3	Q06210,Q06203	2
+EF-hand, Ca insensitive [IPR014837]	0.6752730883813288	0.9307314658377492	0.3519924887592762	1.0	0.8981345487460706	3	O43707,Q13813	2
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.6743828198432129	0.9273889793207464	0.3537246105597065	1.0	0.8988635841209985	3	Q9NUQ9	1
+ERM family, FERM domain C-lobe [IPR041789]	0.6709698775239995	0.9145927505272482	0.3604054659192925	1.0	0.9028246508589638	3	P15311,P26038	2
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.543030972166014	0.906517010534813	0.3646622654437532	1.0	0.9084877481759914	6	Q14168,Q07157,Q9UDY2,Q00013	4
+Guanylate kinase-like domain [IPR008144]	0.543030972166014	0.906517010534813	0.3646622654437532	1.0	0.9084877481759914	6	Q14168,Q07157,Q9UDY2,Q00013	4
+RNA recognition motif domain, eukaryote [IPR003954]	0.5747521970302741	0.9016738586660776	0.3672301435358587	1.0	0.9113663466019724	15	Q14011,Q01130,P38159	3
+PDZ domain 6 [IPR041489]	0.6669976828864503	0.8997360598148549	0.3682607285564616	1.0	0.9125543503652876	3	Q8NEN9,O43464	2
+EB1, C-terminal [IPR004953]	0.7984778292521544	0.8744506429391459	0.3818728882113935	1.0	0.9237243903220308	2	Q15555	1
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.5393008016513158	0.8648039922278706	0.3871463795961563	1.0	0.9270439507241836	5	Q9HCE1,Q92900,P38935	3
+Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]	0.6562353534985946	0.8596952974144177	0.3899570276949133	1.0	0.9270439507241836	3	Q9Y4E8	1
+Dynamin stalk domain [IPR000375]	0.7935142289874275	0.8565227613152068	0.3917086883486786	1.0	0.9270439507241836	2	O00429	1
+Dynamin GTPase effector [IPR003130]	0.7935142289874275	0.8565227613152068	0.3917086883486786	1.0	0.9270439507241836	2	O00429	1
+GTPase effector domain [IPR020850]	0.7935142289874275	0.8565227613152068	0.3917086883486786	1.0	0.9270439507241836	2	O00429	1
+Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]	0.6549283798963611	0.8548552908035887	0.3926312644388812	1.0	0.9270439507241836	3	Q14241	1
+DNA mismatch repair protein MutS, core [IPR007696]	0.6540880503144484	0.8517460798531082	0.3943550391546255	1.0	0.9270439507241836	3	P20585,P43246	2
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.6540880503144484	0.8517460798531082	0.3943550391546255	1.0	0.9270439507241836	3	P20585,P43246	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.6540880503144484	0.8517460798531082	0.3943550391546255	1.0	0.9270439507241836	3	P20585,P43246	2
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.6540880503144484	0.8517460798531082	0.3943550391546255	1.0	0.9270439507241836	3	P20585,P43246	2
+Myosin, N-terminal, SH3-like [IPR004009]	0.5301083877204136	0.8503333390529387	0.3951397860640173	1.0	0.9275476424901892	6	Q9Y4I1,P35579,P35580	3
+Legume-like lectin [IPR005052]	0.7915287888815374	0.8493758220028781	0.3956722023950787	1.0	0.9275476424901892	2	P49257	1
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.7895433487756476	0.8422431071942262	0.3996518892612948	1.0	0.9281355162554894	2	P51812	1
+Intermediate filament, rod domain [IPR039008]	0.5316125925140122	0.8253598316444332	0.4091673326810345	1.0	0.9281355162554894	8	P08670	1
+MCM, AAA-lid domain [IPR041562]	0.52283642780841	0.8189056871911491	0.4128402249031864	1.0	0.9281355162554894	6	Q14566	1
+MCM N-terminal domain [IPR027925]	0.52283642780841	0.8189056871911491	0.4128402249031864	1.0	0.9281355162554894	6	Q14566	1
+MCM OB domain [IPR033762]	0.52283642780841	0.8189056871911491	0.4128402249031864	1.0	0.9281355162554894	6	Q14566	1
+MCM domain [IPR001208]	0.52283642780841	0.8189056871911491	0.4128402249031864	1.0	0.9281355162554894	6	Q14566	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.781601588352087	0.8138597821393575	0.4157252827259543	1.0	0.9289930343858772	2	Q15067	1
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.6385145605317695	0.794535801552322	0.4268835752847233	1.0	0.9457394916822924	3	O60749	1
+Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]	0.7690271343481165	0.7694359699582194	0.4416345420360301	1.0	0.954655572022608	2	O95747	1
+IBR domain [IPR002867]	0.7660489741892813	0.7590137733811664	0.4478443176082751	1.0	0.9592416462630358	2	O95376	1
+Ariadne domain [IPR045840]	0.7660489741892813	0.7590137733811664	0.4478443176082751	1.0	0.9592416462630358	2	O95376	1
+TRIAD supradomain [IPR044066]	0.7660489741892813	0.7590137733811664	0.4478443176082751	1.0	0.9592416462630358	2	O95376	1
+CARG-binding factor, N-terminal [IPR012956]	0.7653871608206541	0.7567031308082531	0.4492277387118135	1.0	0.9606104338154025	2	Q99729	1
+USP8 dimerisation domain [IPR015063]	0.7614162806088712	0.7428813998364774	0.4575534877260978	1.0	0.9624658124051008	2	P40818	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.621710684415406	0.7337963031801845	0.4630728939928037	1.0	0.9667288846359612	3	O15460	1
+Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]	0.6210758968930632	0.7315243892108539	0.464458912967348	1.0	0.9671981519156032	3	O95071	1
+LEM domain [IPR003887]	0.4997519482474382	0.7202985830370415	0.4713411769919635	1.0	0.9718411310433932	6	Q86XL3,P50402	2
+Myosin tail [IPR002928]	0.5616961661050135	0.7147249637122932	0.4747790091248629	1.0	0.9738241623232824	4	P35579,P35580	2
+Saposin B type domain [IPR008139]	0.7495036399735332	0.7018695573803571	0.4827605154838754	1.0	0.9826729613234688	2	P07602	1
+Sulphate adenylyltransferase catalytic domain [IPR024951]	0.744870946393122	0.686114451169465	0.4926409387503747	1.0	0.9856637697013312	2	O95340	1
+ATP-sulfurylase PUA-like domain [IPR025980]	0.744870946393122	0.686114451169465	0.4926409387503747	1.0	0.9856637697013312	2	O95340	1
+Sulphate adenylyltransferase [IPR002650]	0.744870946393122	0.686114451169465	0.4926409387503747	1.0	0.9856637697013312	2	O95340	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.4906752579674758	0.6672480802303652	0.5046136842900246	1.0	0.9905624585337476	7	Q8N4Q0	1
+Brdt, bromodomain, repeat I [IPR043508]	0.7392455327597653	0.6671378445431251	0.5046840887144044	1.0	0.9905624585337476	2	O60885	1
+NET domain [IPR027353]	0.7392455327597653	0.6671378445431251	0.5046840887144044	1.0	0.9905624585337476	2	O60885	1
+Brdt, bromodomain, repeat II [IPR043509]	0.7392455327597653	0.6671378445431251	0.5046840887144044	1.0	0.9905624585337476	2	O60885	1
+Helicase/UvrB, N-terminal [IPR006935]	0.6022904307954627	0.6651302889480014	0.505967163170383	1.0	0.9915727017029298	3	Q92900	1
+Ion transporter-like, CBS domain [IPR044751]	0.7382528127068222	0.6638071383563185	0.5068137563352737	1.0	0.991725780971449	2	Q6P4Q7	1
+CNNM, transmembrane domain [IPR002550]	0.7382528127068222	0.6638071383563185	0.5068137563352737	1.0	0.991725780971449	2	Q6P4Q7	1
+Aldehyde dehydrogenase domain [IPR015590]	0.5030762100641217	0.6599681097589366	0.5092742944061395	1.0	0.9928995787259336	11	Q8IZ83,P30837	2
+Immunoglobulin I-set [IPR013098]	0.5466628365234367	0.6589932841481342	0.5099000812602243	1.0	0.9928995787259336	4	Q15746	1
+Ras GTPase-activating domain [IPR001936]	0.543106634637258	0.6459722297672958	0.5182973401632378	1.0	0.9928995787259336	4	Q13576	1
+GNAT domain [IPR000182]	0.4787420502043844	0.6325454861137983	0.5270304957979697	1.0	0.9928995787259336	6	Q86UY6	1
+14-3-3 domain [IPR023410]	0.4778739884208312	0.6289697745868724	0.5293688443127806	1.0	0.9928995787259336	6	Q04917,P27348,P31946	3
+Zinc finger, CCHC-type [IPR001878]	0.4807439046563984	0.6117946969379872	0.5406735987827789	1.0	0.9928995787259336	8	Q15637,Q16629,Q9BWF3	3
+PurM-like, C-terminal domain [IPR010918]	0.5804147008157113	0.5901432271535719	0.5550946302995152	1.0	0.9928995787259336	3	O15067	1
+Reticulon [IPR003388]	0.7154202514890854	0.5888127061702944	0.555986921309632	1.0	0.9928995787259336	2	O95197	1
+DnaJ domain [IPR001623]	0.504511286367197	0.581451656592962	0.5609360911623005	1.0	0.9928995787259336	17	Q99543,Q8IXB1,O14976,Q9NVH1,O75937,O60884	6
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.4732499151065579	0.5674148969189501	0.5704323311690416	1.0	0.9928995787259336	9	O95302,Q13451,O00170,Q96AY3	4
+Methyltransferase type 11 [IPR013216]	0.5718754595075157	0.5616556400037388	0.5743506634694513	1.0	0.9928995787259336	3	Q8N6R0	1
+Importin-beta, N-terminal domain [IPR001494]	0.483425024191719	0.552682912531866	0.580480556065718	1.0	0.9928995787259336	13	Q9HAV4,Q96P70,O43592,Q92973,O15397	5
+FKBP3, basic tilted helix bundle domain [IPR041200]	0.6992058239576486	0.5376150667737902	0.5908428262407437	1.0	0.9928995787259336	2	Q00688	1
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.6949040370615536	0.5243473591749793	0.6000369626968527	1.0	0.9928995787259336	2	O15460	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.5023672331763833	0.5022270149506213	0.6155078419813518	1.0	0.9928995787259336	4	Q86TI2	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.5484938761999341	0.4862527968280568	0.6267879421385236	1.0	0.9928995787259336	3	Q99797,P52888	2
+Condensin complex subunit 1, C-terminal [IPR032682]	0.6796823295830627	0.4785417672552404	0.632264653988631	1.0	0.9928995787259336	2	P42695	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.5373861435549464	0.4519149027925137	0.6513302879735701	1.0	0.9928995787259336	3	Q9BUJ2	1
+Ran binding domain [IPR000156]	0.4804635761589328	0.4299772556143797	0.6672121861565838	1.0	0.9928995787259336	4	Q9H6Z4,Q9UKX7,P43487	3
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.6538716082064918	0.4053001077043894	0.6852569273399094	1.0	0.9928995787259336	2	P43246	1
+Dilute domain [IPR002710]	0.6528788881535468	0.4026026404725965	0.6872405668777273	1.0	0.9928995787259336	2	Q9Y4I1	1
+Immunoglobulin subtype 2 [IPR003598]	0.4264752262539102	0.4016761876406998	0.6879223514269133	1.0	0.9928995787259336	8	P35613,P10586,Q15746	3
+Immunoglobulin subtype [IPR003599]	0.4264752262539102	0.4016761876406998	0.6879223514269133	1.0	0.9928995787259336	8	P35613,P10586,Q15746	3
+DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]	0.5190334326382061	0.3975364002256918	0.6909719497656133	1.0	0.9928995787259336	3	P28340,Q07864	2
+DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]	0.5190334326382061	0.3975364002256918	0.6909719497656133	1.0	0.9928995787259336	3	P28340,Q07864	2
+SMCs flexible hinge [IPR010935]	0.4157005631003765	0.3770322523512198	0.7061496366878841	1.0	0.9928995787259336	5	O95347,A6NHR9,Q9UQE7,Q9NTJ3	4
+Sec63 domain [IPR004179]	0.5089267733054927	0.3689487266706377	0.7121659428389835	1.0	0.9928995787259336	3	Q8N3C0	1
+Zinc finger, FYVE-related [IPR017455]	0.4073818476986753	0.3489696820692768	0.7271120706625969	1.0	0.9928995787259336	5	O14964,Q15075	2
+FYVE zinc finger [IPR000306]	0.4073818476986753	0.3489696820692768	0.7271120706625969	1.0	0.9928995787259336	5	O14964,Q15075	2
+Pleckstrin homology domain [IPR001849]	0.4570707095672101	0.3332968292680139	0.7389102325751371	1.0	0.9928995787259336	23	Q9BZF3,Q13464,Q9NZM3,O14654,Q8IYI6,P19174	6
+Formin, FH2 domain [IPR015425]	0.4021199072540759	0.3316686452469177	0.7401394791735303	1.0	0.9928995787259336	5	Q27J81,O60879,Q9NSV4,Q9Y613	4
+Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]	0.4021199072540759	0.3316686452469177	0.7401394791735303	1.0	0.9928995787259336	5	Q27J81,O60879,Q9NSV4,Q9Y613	4
+PIN domain [IPR002716]	0.4949410523099044	0.331107979360997	0.7405629246193055	1.0	0.9928995787259336	3	Q9ULX3	1
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.4941651103933683	0.3290694447331437	0.7421031988065168	1.0	0.9928995787259336	3	Q9UPT8	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.404840848806365	0.3257971820253909	0.744577810932221	1.0	0.9928995787259336	8	Q8NE71,O75027,Q9UG63,P28288,P61221,Q9NUQ8,Q9NRK6	7
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.4460908214197763	0.3257121485073888	0.744642151870466	1.0	0.9928995787259336	4	Q9UKA9	1
+WW domain [IPR001202]	0.412428511247664	0.3174433428754107	0.7509072236572121	1.0	0.9928995787259336	11	O60828,Q13576	2
+MRH domain [IPR044865]	0.6184645929847854	0.3150803435113043	0.7527006525864286	1.0	0.9928995787259336	2	P11717	1
+Beta-adaptin appendage, C-terminal subdomain [IPR015151]	0.4875868917576941	0.3120531532623756	0.7550001282600165	1.0	0.9928995787259336	3	P63010,O00203	2
+C2 domain [IPR000008]	0.4189056670005548	0.3057431308634211	0.7598002310960463	1.0	0.9928995787259336	14	P19174,Q9NZM3,A0FGR8	3
+Initiation factor eIF-4 gamma, MA3 [IPR003891]	0.3883881152043523	0.29350339313059	0.7691374063004168	1.0	0.9928995787259336	6	Q9HCG8,Q04637	2
+NSD, Cys-His rich domain [IPR041306]	0.4800596115993764	0.2931778339200103	0.7693862260251498	1.0	0.9928995787259336	3	Q9BZ95	1
+Domain of unknown function DUF1747 [IPR013719]	0.6015883520847198	0.2766925222587718	0.7820162141661751	1.0	0.9928995787259336	2	Q08945	1
+PTB/PI domain [IPR006020]	0.6012574454004048	0.2759712052363663	0.7825701826056795	1.0	0.9928995787259336	2	O60343	1
+Class II aldolase/adducin N-terminal [IPR001303]	0.4713670969877415	0.2721962228888194	0.7854711459327375	1.0	0.9928995787259336	3	P35611,P35612	2
+Post-SET domain [IPR003616]	0.3794100476415877	0.2647770593843711	0.7911812103011138	1.0	0.9928995787259336	6	Q9BZ95,Q03164	2
+RecF/RecN/SMC, N-terminal [IPR003395]	0.3787276341948259	0.2626405004417109	0.7928276807489842	1.0	0.9928995787259336	6	Q14683,O95347,Q9UQE7,Q8IY18,Q9NTJ3	5
+PABP, RNA recognition motif 2 [IPR045305]	0.5949702183984195	0.2624997864011014	0.7929361500135255	1.0	0.9928995787259336	2	Q13310	1
+Immunoglobulin-like domain [IPR007110]	0.3938897563908292	0.2579333453505538	0.7964583494863835	1.0	0.9928995787259336	11	P35613,P10586,Q15746,Q9BY67	4
+Serine/threonine-protein kinase N, first HR1 domain [IPR037313]	0.5909993381866393	0.2542218393661382	0.799324179351161	1.0	0.9928995787259336	2	Q16512	1
+Serine/threonine-protein kinase N, C2 domain [IPR037784]	0.5909993381866393	0.2542218393661382	0.799324179351161	1.0	0.9928995787259336	2	Q16512	1
+Coatomer, WD associated region [IPR006692]	0.5893448047650642	0.2508257103780587	0.8019488628557012	1.0	0.9928995787259336	2	P35606	1
+Translation initiation factor, beta propellor-like domain [IPR013979]	0.4135761589403816	0.2394088505914631	0.8107885677541313	1.0	0.9928995787259336	4	Q9NV06,Q9BY44,P55884	3
+ABC-transporter extension domain [IPR032781]	0.5741230972865737	0.2210599703010437	0.8250457382637877	1.0	0.9928995787259336	2	Q9NUQ8	1
+MIF4G-like, type 3 [IPR003890]	0.3710212201591515	0.219302114024013	0.8264147152307146	1.0	0.9928995787259336	8	P78344,Q09161,Q9HCG8,Q9H074,Q04637,Q5C9Z4,Q9HAU5	7
+ABC transporter type 1, transmembrane domain [IPR011527]	0.4043046357615805	0.2172839309433039	0.8279870792089992	1.0	0.9928995787259336	4	Q9NRK6,P28288,O75027	3
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.3632537350336424	0.2160647465161525	0.8289372788544696	1.0	0.9928995787259336	6	P07437,P04350,Q13885	3
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.3632537350336424	0.2160647465161525	0.8289372788544696	1.0	0.9928995787259336	6	P07437,P04350,Q13885	3
+Formin, GTPase-binding domain [IPR010473]	0.4019867549668695	0.211934757988715	0.8321579335205203	1.0	0.9928995787259336	4	Q27J81,O60879,Q9NSV4	3
+Formin, FH3 domain [IPR010472]	0.4019867549668695	0.211934757988715	0.8321579335205203	1.0	0.9928995787259336	4	Q27J81,O60879,Q9NSV4	3
+CID domain [IPR006569]	0.3630234399915268	0.2058949466294068	0.8368729728882824	1.0	0.9928995787259336	7	O95104	1
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.3625632300502114	0.2045936649080535	0.8378896053787956	1.0	0.9928995787259336	7	P50570,O60313,O00429	3
+Dynamin, N-terminal [IPR045063]	0.3625632300502114	0.2045936649080535	0.8378896053787956	1.0	0.9928995787259336	7	P50570,O60313,O00429	3
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.5628722700198632	0.2007909862416704	0.8408620113339274	1.0	0.9928995787259336	2	Q9Y305	1
+Calponin homology domain [IPR001715]	0.422549006234064	0.1978822415690529	0.8431371986144847	1.0	0.9928995787259336	26	Q96ED9,Q13576,Q8NF91	3
+PurM-like, N-terminal domain [IPR016188]	0.5555923229649329	0.1884653570597328	0.850511869933755	1.0	0.9928995787259336	2	P22102	1
+NAD-dependent epimerase/dehydratase [IPR001509]	0.5529450694904127	0.1841372029698629	0.853905821697073	1.0	0.9928995787259336	2	Q13630	1
+Rab-GTPase-TBC domain [IPR000195]	0.3507784034448625	0.1838252381835166	0.8541505563112082	1.0	0.9928995787259336	5	Q66K14,Q8TC07,O60343,Q9Y3P9	4
+PDZ domain [IPR001478]	0.390957971973689	0.1656694747350419	0.8684170696782338	1.0	0.9928995787259336	20	Q9Y4G8	1
+ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]	0.5363997352746623	0.1589377446801331	0.8737179226982921	1.0	0.9928995787259336	2	Q14240	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.3721854304635702	0.1498850554386805	0.8808553025483954	1.0	0.9928995787259336	4	P98194,P20020,P16615	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.3721854304635702	0.1498850554386805	0.8808553025483954	1.0	0.9928995787259336	4	P98194,P20020,P16615	3
+AWS domain [IPR006560]	0.3649426070650634	0.1367334149702028	0.89124151625203	1.0	0.9928995787259336	4	Q9BZ95	1
+26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]	0.5026472534745308	0.1171834021804899	0.906714719435384	1.0	0.9928995787259336	2	Q13098	1
+THUMP domain [IPR004114]	0.5013236267372707	0.1157995907101418	0.9078113748999186	1.0	0.9928995787259336	2	Q9NXG2	1
+Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]	0.4966909331568579	0.1111005117394597	0.9115366429459476	1.0	0.9928995787259336	2	P09960	1
+EH domain-containing protein, N-terminal [IPR031692]	0.4963600264725457	0.1107733783178897	0.9117960564280674	1.0	0.9928995787259336	2	Q9H4M9	1
+Domain of unknown function DUF5600 [IPR040990]	0.4963600264725457	0.1107733783178897	0.9117960564280674	1.0	0.9928995787259336	2	Q9H4M9	1
+Valyl tRNA synthetase, anticodon-binding domain [IPR033705]	0.4937127729980255	0.1081967523835763	0.9138396210566262	1.0	0.9928995787259336	2	Q5ST30	1
+Transcription factor IIS, N-terminal [IPR017923]	0.3431722609861005	0.1017945151838563	0.9189197792854232	1.0	0.9928995787259336	4	Q14241	1
+RNA-binding S4 domain [IPR002942]	0.4844473858372052	0.0997344984737599	0.920555111256051	1.0	0.9928995787259336	2	P46781	1
+C-CAP/cofactor C-like domain [IPR017901]	0.4831237590999451	0.0985947372037519	0.921460048764818	1.0	0.9928995787259336	2	Q15814	1
+CARP motif [IPR006599]	0.4831237590999451	0.0985947372037519	0.921460048764818	1.0	0.9928995787259336	2	Q15814	1
+FERM, N-terminal [IPR018979]	0.3135565130924661	0.0866798328265978	0.9309260071453216	1.0	0.9928995787259336	7	P35241,Q9HCM4,Q9Y2J2,P26038,P11171,P15311	6
+FERM, C-terminal PH-like domain [IPR018980]	0.3135565130924661	0.0866798328265978	0.9309260071453216	1.0	0.9928995787259336	7	P35241,Q9HCM4,Q9Y2J2,P26038,P11171,P15311	6
+FERM domain [IPR000299]	0.3136604774535843	0.0803906531706086	0.935926560534906	1.0	0.9928995787259336	8	P35241,Q9HCM4,Q9Y490,Q9Y2J2,P26038,P11171,P15311	7
+EF-hand domain [IPR002048]	0.4171159007142847	0.0769372748241034	0.9386734443930268	1.0	0.9928995787259336	40	O95302,Q14257,Q9BPX6,P0DP25,P80303,Q9NZM3,O43852,Q02818,P19174	9
+MoaB/Mog domain [IPR001453]	0.4503639973527527	0.0754676181431286	0.9398426610195884	1.0	0.9928995787259336	2	Q9NQX3	1
+K Homology domain, type 1 [IPR004088]	0.3637698398641254	0.0745503055895398	0.9405725144240004	1.0	0.9928995787259336	24	Q96AE4,P61978,Q8IWZ3,Q15637,Q07666,Q06787,Q9NQT5,Q92945	8
+FERM central domain [IPR019748]	0.3137645107794282	0.0742663296889919	0.9407984680362071	1.0	0.9928995787259336	9	P35241,Q9HCM4,Q9Y490,Q9Y2J2,P26038,Q96AC1,P11171,P15311	8
+Band 4.1 domain [IPR019749]	0.3137645107794282	0.0742663296889919	0.9407984680362071	1.0	0.9928995787259336	9	P35241,Q9HCM4,Q9Y490,Q9Y2J2,P26038,Q96AC1,P11171,P15311	8
+Ubiquitin-like domain [IPR000626]	0.3300120144198049	0.0734001127014197	0.9414877279161772	1.0	0.9928995787259336	14	Q86UV5,Q8WVY7,P46379,P54725	4
+NUC153 [IPR012580]	0.4407677035076234	0.0703722167261519	0.9438974042512857	1.0	0.9928995787259336	2	Q9H501	1
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	0.3014147565333508	0.0700884387134813	0.9441232686427798	1.0	0.9928995787259336	6	Q05655,Q13464,Q8NEN9	3
+CAP Gly-rich domain [IPR000938]	0.3391059408282988	0.070004994843035	0.9441896840835652	1.0	0.9928995787259336	3	Q14203	1
+FERM adjacent (FA) [IPR014847]	0.3132450331125753	0.0647350115839578	0.948384986061978	1.0	0.9928995787259336	4	P11171,Q9Y2J2,Q9HCM4	3
+Dynein heavy chain, tail [IPR013594]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain AAA lid domain [IPR041658]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain region D6 P-loop domain [IPR004273]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, ATP-binding dynein motor region [IPR035706]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, linker [IPR013602]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, C-terminal domain [IPR041228]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, AAA module D4 [IPR024317]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, coiled coil stalk [IPR024743]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]	0.4149569821310495	0.0598021560487584	0.9523132083737832	1.0	0.9928995787259336	2	Q8NCM8	1
+Extended PHD (ePHD) domain [IPR034732]	0.3036944294690915	0.0554296089286325	0.9557962075774014	1.0	0.9928995787259336	4	Q03164	1
+Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]	0.3997352746525576	0.055378426798926	0.9558369823791576	1.0	0.9928995787259336	2	O95782	1
+Ubiquitin-conjugating enzyme E2 [IPR000608]	0.2957848129150792	0.0545443528820893	0.9565014726714473	1.0	0.9928995787259336	7	P61088,Q9C0C9	2
+Chaperone DnaJ, C-terminal [IPR002939]	0.2805564756542001	0.0534447631007771	0.9573775403566188	1.0	0.9928995787259336	5	Q9UBS4,P31689,O60884,P25685	4
+ARHGEF1-like, PH domain [IPR041020]	0.3858371939113233	0.0522850821754128	0.9583015397576208	1.0	0.9928995787259336	2	Q92974	1
+Zinc finger, RING-type [IPR001841]	0.3478840170523682	0.0514978342698802	0.9589288275657076	1.0	0.9928995787259336	23	O94822,O95376,Q96T51,O75150,P19474	5
+SUI1 domain [IPR001950]	0.3706154864328352	0.0497460337698709	0.9603247722036046	1.0	0.9928995787259336	2	P41214	1
+Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]	0.3659827928524249	0.049122068053322	0.9608220168712116	1.0	0.9928995787259336	2	Q13243	1
+Vicinal oxygen chelate (VOC) domain [IPR037523]	0.3093977498345547	0.0451894995266695	0.9639562638652904	1.0	0.9928995787259336	2	Q9HC38	1
+Iron-binding zinc finger, CDGSH type [IPR018967]	0.2786234281932585	0.0446155039465128	0.9644137846032396	1.0	0.9928995787259336	2	Q9NZ45	1
+Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]	0.2786234281932585	0.0446155039465128	0.9644137846032396	1.0	0.9928995787259336	2	Q9NZ45	1
+Amine oxidase [IPR002937]	0.2879841112214386	0.0441379574096851	0.9647944366159332	1.0	0.9928995787259336	3	Q8NB78,P50336	2
+Rhodanese-like domain [IPR001763]	0.2793776895067782	0.0416641441474096	0.9667664379521892	1.0	0.9928995787259336	3	P25325,P40818	2
+ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]	0.2817880794701939	0.0382461508437495	0.9694914247411076	1.0	0.9928995787259336	4	P06576,P21281,P25705	3
+ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]	0.2817880794701939	0.0382461508437495	0.9694914247411076	1.0	0.9928995787259336	4	P06576,P21281,P25705	3
+Endonuclease/exonuclease/phosphatase [IPR005135]	0.2653196422656589	0.0363267909447951	0.971021787949149	1.0	0.9928995787259336	5	Q01968,Q9UNK9,O95551,Q6L8Q7	4
+JmjC domain [IPR003347]	0.2781456953642305	0.0359076852009539	0.9713559679166182	1.0	0.9928995787259336	4	P29375,Q9H6W3,Q9Y2K7	3
+PWWP domain [IPR000313]	0.2866996018110604	0.0303944981877556	0.9757524326403636	1.0	0.9940534654259944	9	Q9BZ95,Q7Z4V5	2
+TGS [IPR004095]	0.2713717693836935	0.0240251044331062	0.9808325840423262	1.0	0.9974503149776376	6	Q9NTK5,Q9BW92,Q9NYK5,P55039,P26639	5
+Myosin head, motor domain [IPR001609]	0.2676616915422827	0.0070831208146001	0.9943485345160048	1.0	1.0	9	P35580,Q7Z406,O94832,Q92614,O00159,P35579,Q9Y4I1,Q9UM54	8
+Peptidase M16, C-terminal [IPR007863]	0.2546281295840558	0.0014381147793745	0.9988525508163956	1.0	1.0	7	O43847	1
+Peptidase M16, N-terminal [IPR011765]	0.2546281295840558	0.0014381147793745	0.9988525508163956	1.0	1.0	7	O43847	1