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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:f047a19a0c2e1781655115f0120a86a83359faeae8c6d749d79aa51af52e1371
+size 71326

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 54,
+    "title": "Average number of proteins per term",
+    "value": 2.537037037037037
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C261/C261_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,9 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.979145978152928	2.0062781674832113	0.0448265780389447	0.9159688327945577	0.2486021973840286	3	Q9H3G5,Q9HB40	2
+Histidine acid phosphatase active site [IPR033379]	0.9738583719391134	1.3210029200826163	0.1865003905675499	0.999985568986489	0.5035510545323849	2	P11117	1
+Cysteine peptidase, cysteine active site [IPR000169]	0.6483103677973692	1.2285635107399473	0.2192355035042288	0.9999984293368545	0.538123508601289	5	P53634,Q13867	2
+Protein-tyrosine phosphatase, active site [IPR016130]	0.5032557882019071	0.6353652210275645	0.5251902454291546	1.0	0.8403679934093227	5	P10586,Q06124	2
+ATP:guanido phosphotransferase active site [IPR022415]	0.758769027134351	0.571938423894728	0.5673636916293869	1.0	0.8510455374440804	2	P12532	1
+Tyrosine-protein kinase, active site [IPR008266]	0.4342932803707348	0.1781678217028081	0.8585911799304151	1.0	0.9574780991030764	3	Q15375,Q13308	2
+Peptidase S9, serine active site [IPR002471]	0.509265387160831	0.0807229775238888	0.9356622630244338	1.0	0.9905823389670756	2	P13798	1
+Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]	0.294837855724694	0.0333415039030177	0.973402256816055	1.0	0.991768337133339	2	P00390	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "MTMR6", "MYLK", "NEK9", "NME1", "NME2", "NME3", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKCD", "PRKD3", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["ACP2", "APEH", "BLMH", "CKMT1A*", "CPVL", "CTSC", "EPHA7", "GSR", "PTK7", "PTPN11", "PTPRF", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "IQ motif, EF-hand binding site [IPR000048]", "1": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:0dba9d6222fee6a90542f600c22f1ce7cefcaa97d6888323ae12cc50cc08ae02
+size 67832

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.40625
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C261/C261_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+IQ motif, EF-hand binding site [IPR000048]	0.4502961085023313	0.4353797054926776	0.6632868387560507	0.9999999999999992	0.9733960998238312	13	Q7Z406,Q9Y4I1,Q92614,P35579,O94832,P35580	6
+EF-Hand 1, calcium-binding site [IPR018247]	0.3530447944428226	0.2165101842610171	0.8285900875281722	1.0	0.9733960998238312	35	O95302,Q02818,Q9BRK5,Q96AY3,Q14257,O43852,P80303	7
+Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]	0.3146922567835951	0.0335591695710411	0.9732286818763064	1.0	0.9733960998238312	2	Q9UQ80	1
+Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]	0.295830575777639	0.0333492248397284	0.9733960998238312	1.0	0.9733960998238312	2	P34896	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PPM1L", "PRKCD", "PRKCSH", "PRKD3", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP10", "FKBP9", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1D", "MYO5A", "NUCB1", "NUCB2", "PA2G4", "RCN2", "SDF4", "SHMT1"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Bromodomain, conserved site [IPR018359]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:48b0999be801d8ce02f7caf1041b6475850db4e465ef50d3e009b9255777405a
+size 77250

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Mini-chromosome maintenance, conserved site [IPR018525]	0	6	2.220368057991363	0.026393793481263	2.866504854368932	6.0	0.6014171079911801	0.4512524973950094	1.9129462909638515	0.0	0.8774532383159435	0.3049228525869014	1.0	1.0	1.0	0.1347742043692028	0.2563613716250874
+Proteasome beta-type subunit, conserved site [IPR016050]	5	8	2.2176856277483616	0.0265762748773974	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	1.0	1.0	0.0036065315551905	5.904010755783799e-05	2.153691644866261e-06

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 269,
+    "title": "Average number of proteins per term",
+    "value": 2.684014869888476
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C261/C261_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,35 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.870514376663212	2.2176856277483616	0.0265762748773974	0.9992867884417036	0.5328938930072068	8	P28074,P28072,P28070,P49721,P49720	5
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.9437331507149688	2.1367614361986584	0.0326174002117725	0.9998663604400828	0.5328938930072068	4	Q99536	1
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.7570406464462826	2	P05067	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.7570406464462826	2	P05067	1
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.7570406464462826	2	P05067	1
+Sterol reductase, conserved site [IPR018083]	0.9731965585704836	1.318558188083098	0.1873168598256502	1.0	0.7571072479935715	2	Q9UBM7	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.9715420251489084	1.3124475151743435	0.1893691838206301	1.0	0.7571072479935715	2	P13473	1
+Sulfatase, conserved site [IPR024607]	0.9682329583057586	1.3002313354793948	0.1935216938222166	1.0	0.7571072479935715	2	P15586	1
+Haem oxygenase conserved site [IPR018207]	0.9665784248841828	1.294125952064563	0.1956219186497336	1.0	0.7571072479935715	2	P30519	1
+Tetraspanin, conserved site [IPR018503]	0.962276637988088	1.2782609481579772	0.2011574324245932	1.0	0.7571072479935715	2	O60637	1
+C-type lectin, conserved site [IPR018378]	0.955658504301788	1.2538807725770678	0.2098853446617243	1.0	0.7734131193699159	2	Q5KU26	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.9410986101919272	1.2003813404867931	0.2299912723187405	1.0	0.8034760032953403	2	Q07954	1
+Guanylate kinase, conserved site [IPR020590]	0.6507310827388413	1.0150691013850788	0.3100728892135123	1.0	0.8402052739678411	4	Q9NZW5	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.6921566553880893	0.9387952804085914	0.3478358625414834	1.0	0.8402052739678411	3	P09429	1
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.6508612880364333	0.7898365451133863	0.4296232333797345	1.0	0.8898796302729158	3	Q96CW1	1
+Ras GTPase-activating protein, conserved site [IPR023152]	0.6150281363786838	0.6653004806191832	0.5058583232511253	1.0	0.940576240000733	3	Q13576,Q86VI3	2
+Phosphofructokinase, conserved site [IPR015912]	0.5958291956305776	0.6010373390670563	0.5478151169263472	1.0	0.9507242996979832	3	Q01813,P17858	2
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.7590999338186677	0.572954850425757	0.5666752645527571	1.0	0.9709276825776538	2	P04439	1
+Polyamine biosynthesis domain, conserved site [IPR030373]	0.7567835870284609	0.5658541532992213	0.5714929299357789	1.0	0.9729847984349654	2	P19623	1
+S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]	0.7425545996029171	0.5229919541507266	0.6009798523289793	1.0	0.9857535382713136	2	O43865	1
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.7233620119126446	0.4673895539868845	0.6402211948796703	1.0	1.0	2	O60573	1
+AT hook, DNA-binding motif [IPR017956]	0.5453025309180739	0.4429496876209954	0.6578021266140233	1.0	1.0	3	Q9UIF9	1
+DNA-directed DNA polymerase, family B, conserved site [IPR017964]	0.7064857710125791	0.4207984491542427	0.673902264205775	1.0	1.0	2	P09884	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.4326908140941469	0.4115852993343507	0.6806434084313269	1.0	1.0	6	Q12846,Q13277	2
+Dynamin, GTPase region, conserved site [IPR019762]	0.6681005956320376	0.3238504585800375	0.7460512525837739	1.0	1.0	2	P50570	1
+Zinc finger, RING-type, conserved site [IPR017907]	0.3757254357128246	0.1731041175236392	0.8625695884971298	1.0	1.0	13	Q9NS91,P19474	2
+Vinculin, conserved site [IPR000633]	0.5208471211118564	0.0898848490989227	0.9283787210798812	1.0	1.0	2	P18206	1
+Chromo domain, conserved site [IPR023779]	0.3003906138612625	0.0693294454611362	0.9447273880317928	1.0	1.0	5	Q13185,O14646	2
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.4910655195235018	0.068578994037606	0.945324739823266	1.0	1.0	2	P06737	1
+Cadherin conserved site [IPR020894]	0.4331568497683754	0.0448861041021575	0.9641980930014408	1.0	1.0	2	Q14126	1
+Actin/actin-like conserved site [IPR020902]	0.2893081761006206	0.0430128492423674	0.965691291119541	1.0	1.0	3	P61163,P61160	2
+RNA polymerase, beta subunit, conserved site [IPR007121]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	1.0	2	Q9H9Y6	1
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.3431502316346871	0.0342365439858219	0.9726885257255382	1.0	1.0	2	P29692	1
+Bromodomain, conserved site [IPR018359]	0.2826808228268134	0.001724929425364	0.9986237061255274	1.0	1.0	10	Q9UIG0,O15164,Q9UIF9,O60885,P25440,Q9NRL2,P51532,Q12830,Q8WWQ0	9

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Deoxyribonuclease, TatD-related, conserved site [IPR018228]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamine synthetase, N-terminal conserved site [IPR027302]", "Glutamine synthetase, glycine-rich site [IPR027303]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARIH2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FBXW11", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK2", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GLUL", "GMPPA", "GMPPB", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT1", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IQGAP3", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MIF", "MOCS1", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSD3", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAD18", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RCL1", "RDH13", "RDX", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE1", "SYNE2", "TATDN1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACTR1A", "ACTR2", "AHCYL1", "AP2M1", "APP", "BAZ1A", "BAZ1B", "BAZ2A", "BPTF", "BRD2", "BRD4", "CBX3", "CHD1", "COLEC12", "DHCR7", "DNM2", "DSG2", "EEF1D", "EIF4E2", "GNS", "HLA-A", "HMGB1", "HMOX2", "IQGAP2", "IQGAP3", "LAMP2", "LRP1", "MPP6", "PFKL", "PFKP", "PHIP", "POLA1", "POLR1B", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PYGL", "RAD18", "SMARCA4", "SRM", "STX3", "STX4", "TRIM21", "TRIM24", "TSPAN3", "VAT1", "VCL"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Myosin head, motor domain [IPR001609]", "1": "PDZ domain [IPR001478]", "2": "SH3 domain [IPR001452]", "3": "CID domain [IPR006569]", "4": "EF-hand domain [IPR002048]", "5": "Importin-beta, N-terminal domain [IPR001494]", "6": "RecF/RecN/SMC, N-terminal [IPR003395]", "7": "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "8": "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "9": "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "10": "Dynamin, N-terminal [IPR045063]", "11": "MPN domain [IPR037518]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:b862ae639ac7578e546ff404da95314edac4acc65dd21bc2f939450b6661fcaf
+size 159330

interpro_domain/df_merge.tsv

@@ -0,0 +1,7 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+MCM, AAA-lid domain [IPR041562]	0	6	2.220368057991363	0.026393793481263	2.9174757281553396	6.104368932038835	0.6135042301649359	0.4540469304417752	1.9478605233288435	0.3057385452701507	0.8659204488967809	0.3058053287456033	1.0	1.0	1.0	0.1755500699412104	0.326301882193565
+MCM OB domain [IPR033762]	0	6	2.220368057991363	0.026393793481263	2.9174757281553396	6.104368932038835	0.6135042301649359	0.4540469304417752	1.9478605233288435	0.3057385452701507	0.8659204488967809	0.3058053287456033	1.0	1.0	1.0	0.1755500699412104	0.326301882193565
+MCM domain [IPR001208]	0	6	2.220368057991363	0.026393793481263	2.9174757281553396	6.104368932038835	0.6135042301649359	0.4540469304417752	1.9478605233288435	0.3057385452701507	0.8659204488967809	0.3058053287456033	1.0	1.0	1.0	0.1755500699412104	0.326301882193565
+MCM N-terminal domain [IPR027925]	0	6	2.220368057991363	0.026393793481263	2.866504854368932	6.0	0.6014171079911801	0.4512524973950094	1.9129462909638515	0.0	0.8774532383159435	0.3049228525869014	1.0	1.0	1.0	0.1347742043692028	0.2563613716250874
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	1	5	2.1822647660051104	0.0290899977973047	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	0.034779097796398	0.0714416582380786	0.0144068300451448	0.0534326094824991
+Aminopeptidase N-like , N-terminal domain [IPR045357]	1	5	2.1822647660051104	0.0290899977973047	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	0.034779097796398	0.0714416582380786	0.0144068300451448	0.0534326094824991

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3024,
+    "annotations_size": 2581,
+    "title": "Average number of proteins per term",
+    "value": 2.143355288647811
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C261/C261_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,218 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8818265085064632	2.1822647660051104	0.0290899977973047	1.0	0.5685637046542383	5	Q9UIQ6	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8818265085064632	2.1822647660051104	0.0290899977973047	1.0	0.5685637046542383	5	Q9UIQ6	1
+Fibronectin type II domain [IPR000562]	0.9480442427372122	1.8927131258454937	0.0583960299040211	1.0	0.5685637046542383	3	P11717	1
+Cyclic nucleotide-binding domain [IPR000595]	0.8528672040747273	1.7967942962845478	0.072368282201257	1.0	0.5927988577252072	4	P10644,Q6P4Q7	2
+EGF-like domain [IPR000742]	0.894405825885457	1.6945613110193354	0.0901586716551987	1.0	0.6183650997068113	3	O94813,Q07954	2
+Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]	0.7483405148360414	1.6452663933698917	0.0999148870412192	1.0	0.6183650997068113	5	P25398,P55769	2
+Tim10-like [IPR004217]	0.8778550148957277	1.6329159924921188	0.1024866661496139	1.0	0.6209344726106895	3	Q9Y5J9,O60220	2
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.7286408645117952	1.6233469494603336	0.1045152584532127	1.0	0.6244302825642178	6	Q9UMX5	1
+CBS domain [IPR000644]	0.8037746188943569	1.6089592526147534	0.1076252517887079	1.0	0.6300794913623878	4	P51790,Q6P4Q7	2
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.8702416418404367	1.6044925764214195	0.1086055195008588	1.0	0.6327558596652746	3	Q9NRF9,Q9NR33	2
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.7184485341879085	1.5808552060519625	0.1139111483624901	1.0	0.6416758191917195	6	Q99536	1
+PIN domain [IPR002716]	0.8566181648350158	1.5535388649949575	0.1202944517707762	1.0	0.6508990935379089	3	Q9ULX3	1
+Formin, GTPase-binding domain [IPR010473]	0.7602380493527683	1.440548162877718	0.1497123740660748	1.0	0.6810837936926832	4	O60879	1
+Formin, FH3 domain [IPR010472]	0.7602380493527683	1.440548162877718	0.1497123740660748	1.0	0.6810837936926832	4	O60879	1
+Myosin tail [IPR002928]	0.7529801324503269	1.4123525582848642	0.1578461780261331	1.0	0.6838033067727681	4	Q7Z406,P35579,P35580	3
+SUN domain [IPR012919]	0.8176100628930818	1.4071512561700583	0.1593825419578149	1.0	0.6838033067727681	3	O94901,Q9ULT8	2
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.9950363997352748	1.3993507005655246	0.1617078427711717	1.0	0.6838033067727681	2	P05067	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.6740180692912419	1.395057064249427	0.1629986322551877	1.0	0.6851267964974606	7	Q99536	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9887491727332892	1.3760706808290144	0.1687997516611479	1.0	0.6904471617074845	2	P61916	1
+Zinc finger, FYVE-related [IPR017455]	0.6805007038887431	1.363379881875633	0.1727628181547356	1.0	0.6962238062885722	5	Q15075,Q96T51	2
+FYVE zinc finger [IPR000306]	0.6805007038887431	1.363379881875633	0.1727628181547356	1.0	0.6962238062885722	5	Q15075,Q96T51	2
+SET domain [IPR001214]	0.6598049991167357	1.3392316363209662	0.1804952763484075	1.0	0.7070461576146185	9	Q9H7B4	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.7965151723805457	1.327831554932254	0.1842337600370212	1.0	0.70865474613346	3	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.7965151723805457	1.327831554932254	0.1842337600370212	1.0	0.70865474613346	3	P10321	1
+MHC class I-like antigen recognition-like [IPR011161]	0.7965151723805457	1.327831554932254	0.1842337600370212	1.0	0.70865474613346	3	P10321	1
+Immunoglobulin C1-set [IPR003597]	0.7965151723805457	1.327831554932254	0.1842337600370212	1.0	0.70865474613346	3	P10321	1
+F-BAR domain [IPR031160]	0.7931148626282664	1.3150454869828003	0.1884946156345859	1.0	0.7123054216000969	3	Q9UNF0,Q9UKS6	2
+FCH domain [IPR001060]	0.7931148626282664	1.3150454869828003	0.1884946156345859	1.0	0.7123054216000969	3	Q9UNF0,Q9UKS6	2
+Sulfatase, N-terminal [IPR000917]	0.9682329583057586	1.3002313354793948	0.1935216938222166	1.0	0.7185702206311039	2	P15586	1
+GMP phosphodiesterase, delta subunit [IPR008015]	0.9679020516214436	1.2990101108020484	0.193940459342693	1.0	0.7185702206311039	2	A6NIH7	1
+Myosin, N-terminal, SH3-like [IPR004009]	0.6507001326572788	1.295563084285543	0.195126054282525	1.0	0.7188327432476542	6	Q7Z406,P35579,P35580,Q9Y4I1	4
+EXPERA domain [IPR033118]	0.9669093315684985	1.2953468797495518	0.1952005939720611	1.0	0.7188327432476542	2	Q15125	1
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.958967571144938	1.2660664892766589	0.2054892788349154	1.0	0.7266128949137832	2	O00462	1
+C-type lectin-like [IPR001304]	0.955658504301788	1.2538807725770678	0.2098853446617243	1.0	0.7275480660475457	2	Q5KU26	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.955658504301788	1.2538807725770678	0.2098853446617243	1.0	0.7275480660475457	2	Q5KU26	1
+Domain of unknown function DUF4749 [IPR031847]	0.7635786421040918	1.204093850635005	0.2285533064515856	1.0	0.7329001920540554	3	Q53GG5	1
+EGF-like calcium-binding domain [IPR001881]	0.9410986101919272	1.2003813404867931	0.2299912723187405	1.0	0.7346627151666698	2	Q07954	1
+PITH domain [IPR010400]	0.9295168762409004	1.157985651638363	0.2468698918516954	1.0	0.7562410095513216	2	Q9GZP4	1
+Myosin head, motor domain [IPR001609]	0.6166523038904997	1.1502547647210224	0.2500389560530891	1.0	0.7562410095513216	9	Q7Z406,Q9Y4I1,P35579,P35580,O94832	5
+Saposin B type domain [IPR008139]	0.9262078093977518	1.1459028123163069	0.2518353674726472	1.0	0.7562410095513216	2	P07602	1
+Immunoglobulin-like domain [IPR007110]	0.608400691199478	1.1199694922804275	0.2627267628151255	1.0	0.7679476498593872	11	P35613,P04439,P10321	3
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.9149569821310408	1.104934403528786	0.2691880137095637	1.0	0.7754177046700713	2	P06865	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.9149569821310408	1.104934403528786	0.2691880137095637	1.0	0.7754177046700713	2	P06865	1
+Mu homology domain [IPR028565]	0.6590882950801368	1.047319152070442	0.294952405780907	1.0	0.7992086675109328	4	Q96CW1,P48444	2
+HR1 rho-binding domain [IPR011072]	0.6565514885346481	1.037520574149432	0.2994933123343168	1.0	0.8020928130056312	4	Q15642,Q16512	2
+Tudor domain [IPR002999]	0.5901798627537681	1.0345553467437858	0.3008766166554484	1.0	0.8020928130056312	8	Q14739	1
+Zinc finger, CXXC-type [IPR002857]	0.7092460552639188	1.0016253355843452	0.3165245798226481	1.0	0.8155356286231222	3	P26358	1
+PDZ domain [IPR001478]	0.558962481351249	0.9813173708221912	0.3264362591825449	1.0	0.826011749951126	20	O00560,Q9UDY2,Q9NZW5,Q53GG5,Q14168,Q9Y4G8,O14745,O00151,Q8NEN9	9
+Ricin B, lectin domain [IPR000772]	0.5882004147742215	0.977530435252972	0.3283066177638623	1.0	0.829118767562161	5	Q9UBG0	1
+L27 domain [IPR004172]	0.6980066402144287	0.9602398719797696	0.3369345039812568	1.0	0.8333233350106823	3	Q9NZW5	1
+L27 domain, C-terminal [IPR014775]	0.6980066402144287	0.9602398719797696	0.3369345039812568	1.0	0.8333233350106823	3	Q9NZW5	1
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.5838400472128538	0.9594693176774056	0.3373223693737495	1.0	0.8333233350106823	5	Q9HD20,P20020	2
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.6356250996765733	0.9570287243875978	0.3385527569165647	1.0	0.8352761320941386	4	Q9UKA9	1
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.6885137371731177	0.925477726902838	0.354717464207452	1.0	0.854702284023637	3	O60749,Q9UNH7	2
+Homeobox domain [IPR001356]	0.8636664460622134	0.9210972230616084	0.356999669932724	1.0	0.854702284023637	2	Q9UPW6	1
+PDZ domain 6 [IPR041489]	0.6869971576303883	0.9199421694990876	0.3576029806680367	1.0	0.854702284023637	3	Q8NEN9	1
+F-box domain [IPR001810]	0.5639967076700751	0.8777462665944302	0.3800814303891728	1.0	0.8771124190716401	5	Q14241,Q9Y2K7	2
+Dbl homology (DH) domain [IPR000219]	0.5625203962612741	0.8717021592029872	0.3833708820356412	1.0	0.8787568796927087	5	Q9NZM3,Q6XZF7	2
+Zinc finger, LIM-type [IPR001781]	0.5523915585836362	0.870207677013684	0.3841869212856887	1.0	0.8789814980373161	11	Q53GG5,Q9UGI8,P49023,Q16527	4
+DMAP1-binding domain [IPR010506]	0.8484447385837208	0.8677638666047247	0.3855236146354208	1.0	0.8789814980373161	2	P26358	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.8401720714758443	0.8390758592230925	0.4014267419094095	1.0	0.8879921335105383	2	Q96AE4	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.6540880503144606	0.8012948408276201	0.4229609769027145	1.0	0.8986014476337105	3	Q1KMD3,Q00839	2
+Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]	0.6527639854352797	0.796588785221212	0.4256898927631165	1.0	0.9011812214393562	3	P51784,Q86UV5	2
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.8219722038385193	0.7767968554712974	0.4372786322912247	1.0	0.908377639338987	2	O15254	1
+Glycosyltransferase 2-like [IPR001173]	0.5869005867322841	0.7731679617645303	0.4394229842706005	1.0	0.9102333245605296	4	Q10472,Q10471	2
+CNNM, transmembrane domain [IPR002550]	0.8193249503639991	0.7678418811193314	0.4425811294262027	1.0	0.9123817053107264	2	Q6P4Q7	1
+Ion transporter-like, CBS domain [IPR044751]	0.8193249503639991	0.7678418811193314	0.4425811294262027	1.0	0.9123817053107264	2	Q6P4Q7	1
+SUN coiled coil domain 2 [IPR040994]	0.8173395102581094	0.7611440568431209	0.4465710281958381	1.0	0.9176750189279126	2	O94901	1
+Zasp-like motif [IPR006643]	0.8143613500992766	0.7511275126301196	0.4525759194238627	1.0	0.918587830563692	2	Q53GG5	1
+Zinc finger, CHHC-type [IPR012996]	0.6355511420059501	0.7359814859753687	0.4617419649905523	1.0	0.918587830563692	3	P31943,P55795	2
+Ribosomal Proteins L2, RNA binding domain [IPR022666]	0.8057577763070841	0.7224018043062066	0.4700474779167027	1.0	0.9190852579568256	2	P62917	1
+Ribosomal protein L2, C-terminal [IPR022669]	0.8057577763070841	0.7224018043062066	0.4700474779167027	1.0	0.9190852579568256	2	P62917	1
+DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]	0.6292618338298507	0.7141243886683484	0.475150266269162	1.0	0.9215892816191688	3	P28340,P09884	2
+DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]	0.6292618338298507	0.7141243886683484	0.475150266269162	1.0	0.9215892816191688	3	P28340,P09884	2
+N-acetylgalactosaminyltransferase [IPR045885]	0.6287859146182235	0.7124772114451869	0.476169318107958	1.0	0.9215892816191688	3	Q10472	1
+Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]	0.6279377689506753	0.7095441626694531	0.4779868560231715	1.0	0.9215892816191688	3	P51784,Q9Y4E8	2
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.6183062947098996	0.6764618577294105	0.4987474548976949	1.0	0.9261563606667662	3	Q7L576	1
+Immunoglobulin V-set domain [IPR013106]	0.6163522012578544	0.6698023840286225	0.5029837736283578	1.0	0.9323255571633604	3	Q9Y624,Q9BY67	2
+EF-hand, Ca insensitive [IPR014837]	0.6160211850380491	0.6686761107879123	0.503702109665042	1.0	0.9323255571633604	3	Q13813,O43707	2
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5006320376390759	0.6681958744059847	0.5040085685948308	1.0	0.9323255571633604	6	Q9UDY2,Q9NZW5	2
+Guanylate kinase-like domain [IPR008144]	0.5006320376390759	0.6681958744059847	0.5040085685948308	1.0	0.9323255571633604	6	Q9UDY2,Q9NZW5	2
+RasGAP protein, C-terminal [IPR000593]	0.6150281363786838	0.6653004806191832	0.5058583232511253	1.0	0.9339201232554756	3	Q13576,Q86VI3	2
+SKP1 component, POZ domain [IPR016073]	0.7713434811383215	0.6110264784884966	0.5411820510344445	1.0	0.953749468373174	2	P63208	1
+Ras GTPase-activating domain [IPR001936]	0.5417218543046234	0.6101271396953941	0.5417775897649462	1.0	0.953749468373174	4	Q13576,Q86VI3,P46940	3
+Phosphofructokinase domain [IPR000023]	0.5958291956305776	0.6010373390670563	0.5478151169263472	1.0	0.95728559024164	3	Q01813,P17858	2
+Target SNARE coiled-coil homology domain [IPR000727]	0.4858830441345305	0.5964434760983304	0.5508790037720341	1.0	0.9613378693276676	8	Q12846,Q13277,Q9BZF9	3
+Rpn11/EIF3F, C-terminal [IPR024969]	0.53315588644585	0.5803736161440148	0.5616626933587565	1.0	0.9663262212816992	4	Q7L5N1,P51665	2
+ATP:guanido phosphotransferase, catalytic domain [IPR022414]	0.758769027134351	0.571938423894728	0.5673636916293869	1.0	0.971100694608817	2	P12532	1
+ATP:guanido phosphotransferase, N-terminal [IPR022413]	0.758769027134351	0.571938423894728	0.5673636916293869	1.0	0.971100694608817	2	P12532	1
+Tyrosine-specific protein phosphatases domain [IPR000387]	0.5298718298047509	0.5690836494580239	0.5692993738447065	1.0	0.971100694608817	4	P10586	1
+Polyamine biosynthesis  domain [IPR030374]	0.7567835870284609	0.5658541532992213	0.5714929299357789	1.0	0.971100694608817	2	P19623	1
+Spermidine synthase, tetramerisation domain [IPR035246]	0.7567835870284609	0.5658541532992213	0.5714929299357789	1.0	0.971100694608817	2	P19623	1
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.5848182502214598	0.5651174415538983	0.5719938859168767	1.0	0.971100694608817	3	P10586	1
+Ubiquitin system component CUE [IPR003892]	0.5287068890871657	0.5650950125633692	0.572009140659792	1.0	0.971100694608817	4	Q9H0E2	1
+Ras-associating (RA) domain [IPR000159]	0.5278144161374536	0.5620451111557921	0.5740852840643869	1.0	0.971100694608817	4	Q9Y4G8	1
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.4698230383095464	0.5399781887675404	0.5892120743311482	1.0	0.978944159307	7	Q8N4Q0	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.4698169613683247	0.5272862329156804	0.5979948331435703	1.0	0.989374784835612	9	O95302,Q96AY3,O00170	3
+S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]	0.7425545996029171	0.5229919541507266	0.6009798523289793	1.0	0.9936041686077904	2	O43865	1
+Condensin complex subunit 1, C-terminal [IPR032682]	0.7392455327597657	0.5132180201728798	0.6077988220320409	1.0	0.9966510544248396	2	P42695	1
+Immunoglobulin subtype 2 [IPR003598]	0.4625569636592788	0.505105325517136	0.6134848611204569	1.0	0.997643864188127	8	P35613	1
+Immunoglobulin subtype [IPR003599]	0.4625569636592788	0.505105325517136	0.6134848611204569	1.0	0.997643864188127	8	P35613	1
+Band 7 domain [IPR001107]	0.4606163385264681	0.5048603031894384	0.6136569574135884	1.0	0.997643864188127	7	P27105	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.7362673726009301	0.5044866121916793	0.6139194676928312	1.0	0.997643864188127	2	Q9BQ67	1
+Serine/threonine-protein kinase N, first HR1 domain [IPR037313]	0.7349437458636716	0.5006260793980674	0.6166343047783214	1.0	0.997643864188127	2	Q16512	1
+Serine/threonine-protein kinase N, C2 domain [IPR037784]	0.7349437458636716	0.5006260793980674	0.6166343047783214	1.0	0.997643864188127	2	Q16512	1
+SH3 domain [IPR001452]	0.4140142128209824	0.4807534228221468	0.630691757301423	1.0	0.997643864188127	32	Q9UKS6,Q9UDY2,Q9UQB8,Q6XZF7,Q9NZM3,P15924	6
+Syntaxin, N-terminal domain [IPR006011]	0.5005806208357801	0.4716259135377019	0.6371938268277471	1.0	0.997643864188127	4	Q12846,Q13277	2
+ERM family, FERM domain C-lobe [IPR041789]	0.5484938761999315	0.4523788152019397	0.6509961058880056	1.0	0.997643864188127	3	P26038,P35241	2
+Transcription factor IIS, N-terminal [IPR017923]	0.492827865439735	0.4469195164425855	0.6549331720602227	1.0	0.997643864188127	4	Q14241	1
+Protein kinase, C-terminal [IPR017892]	0.4398012276855748	0.4367423551012502	0.662298208605544	1.0	0.997643864188127	6	Q05655,Q16513,Q16512	3
+Importin-alpha, importin-beta-binding domain [IPR002652]	0.4874172185430323	0.4299773192977822	0.6672121398310922	1.0	0.997643864188127	4	O00505,P52294,P52292	3
+Brdt, bromodomain, repeat II [IPR043509]	0.7041694242223739	0.4145827512250135	0.6784473773242723	1.0	0.997643864188127	2	O60885	1
+Brdt, bromodomain, repeat I [IPR043508]	0.7041694242223739	0.4145827512250135	0.6784473773242723	1.0	0.997643864188127	2	O60885	1
+NET domain [IPR027353]	0.7041694242223739	0.4145827512250135	0.6784473773242723	1.0	0.997643864188127	2	O60885	1
+Zinc finger, TFIIB-type [IPR013137]	0.701853077432169	0.4084117763839611	0.6829713890612641	1.0	0.997643864188127	2	P29083	1
+Nucleotidyl transferase domain [IPR005835]	0.52300562727574	0.3795150189410582	0.7043054535156659	1.0	0.997643864188127	3	Q96IJ6,Q9Y5P6	2
+Sorting nexin, N-terminal [IPR005329]	0.6882859033752533	0.3731900549536456	0.7090069974030218	1.0	0.997643864188127	2	O60749	1
+Translation initiation factor IF2/IF5 domain [IPR002735]	0.683984116479158	0.3623607294595408	0.7170824816028372	1.0	0.997643864188127	2	P55010	1
+Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]	0.6763732627399128	0.343614053327504	0.7311365545497028	1.0	0.997643864188127	2	Q8WXI9	1
+Reticulon [IPR003388]	0.6737260092653926	0.3372193724877607	0.7359515345795917	1.0	0.997643864188127	2	O95197	1
+Glutamine amidotransferase [IPR017926]	0.4533112582781312	0.3295202722224461	0.7417624737564916	1.0	0.997643864188127	4	P17812,Q9NRF8,P27708	3
+Plectin/S10, N-terminal [IPR005326]	0.6700860357379276	0.3285345272759616	0.7425075426901755	1.0	0.997643864188127	2	P46783	1
+Alpha/beta hydrolase fold-1 [IPR000073]	0.4079489902153372	0.328118294122891	0.7428222223260419	1.0	0.997643864188127	6	P34913,Q9Y570	2
+Dynamin GTPase effector [IPR003130]	0.6681005956320376	0.3238504585800375	0.7460512525837739	1.0	0.997643864188127	2	P50570	1
+Dynamin stalk domain [IPR000375]	0.6681005956320376	0.3238504585800375	0.7460512525837739	1.0	0.997643864188127	2	P50570	1
+GTPase effector domain [IPR020850]	0.6681005956320376	0.3238504585800375	0.7460512525837739	1.0	0.997643864188127	2	P50570	1
+CID domain [IPR006569]	0.4086841233012804	0.3209829479525308	0.7482233132903369	1.0	0.997643864188127	7	Q8IWX8,Q96P16,O15042,O95104,Q9NQG5,Q9UPN6	6
+Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]	0.4991054162620447	0.3167234166632698	0.7514534789396274	1.0	0.997643864188127	3	Q14241	1
+EB1, C-terminal [IPR004953]	0.656187954996697	0.2965481386316838	0.7668115099034236	1.0	0.997643864188127	2	Q15555	1
+AGC-kinase, C-terminal [IPR000961]	0.3991125614505763	0.2903136237881326	0.7715763171794985	1.0	0.997643864188127	7	Q05655,Q16513,Q16512	3
+Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]	0.6532097948378618	0.2899409887286191	0.7718613833307866	1.0	0.997643864188127	2	Q13557	1
+Ubiquitin-like domain, USP-type [IPR028135]	0.6525479814692319	0.2884847688962815	0.7729756878312395	1.0	0.997643864188127	2	P51784	1
+Methyltransferase type 11 [IPR013216]	0.4753392916252829	0.2602450454268795	0.7946747597279546	1.0	0.997643864188127	3	Q8N6R0,O43709	2
+Formin, FH2 domain [IPR015425]	0.3903487422795404	0.2538009804080857	0.7996493159841971	1.0	0.997643864188127	5	O60879	1
+Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]	0.3903487422795404	0.2538009804080857	0.7996493159841971	1.0	0.997643864188127	5	O60879	1
+Pre-SET domain [IPR007728]	0.630046326935811	0.2416313347429403	0.8090658398014956	1.0	0.997643864188127	2	Q96KQ7	1
+Zinc finger, RING-type [IPR001841]	0.3973998053893572	0.2412892857956392	0.8093309143097343	1.0	0.997643864188127	23	Q9NS91,O95376,Q96T51,P19474	4
+Chromo domain [IPR023780]	0.3816022910463395	0.2373352463293006	0.8123967204787554	1.0	0.997643864188127	7	Q13185,Q9HCK8,O14646	3
+Protein-tyrosine phosphatase, catalytic [IPR003595]	0.3824699770688975	0.2326167714819173	0.8160590027716188	1.0	0.997643864188127	5	P10586,Q06124	2
+Exportin-1/Importin-beta-like [IPR013598]	0.41208098966293	0.2251585797026807	0.8218559107200665	1.0	0.997643864188127	4	Q9Y5L0	1
+CTP synthase GATase domain [IPR033828]	0.6151555261416354	0.2135335420869008	0.8309108295520646	1.0	0.997643864188127	2	Q9NRF8	1
+CTP synthase, N-terminal [IPR017456]	0.6151555261416354	0.2135335420869008	0.8309108295520646	1.0	0.997643864188127	2	Q9NRF8	1
+Methylglyoxal synthase-like domain [IPR011607]	0.6115155526141702	0.2070242332343971	0.8359909330662656	1.0	0.997643864188127	2	P31939	1
+Gelsolin-like domain [IPR007123]	0.3669576844828531	0.2064882801084447	0.8364095186066964	1.0	0.997643864188127	6	Q13045,O95425	2
+KOW [IPR005824]	0.3646902947996098	0.1881760051830533	0.8507386815567619	1.0	0.997643864188127	5	P61353,P61254,P62701,O00267	4
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.3912374254073928	0.1805761364091926	0.8567002883170072	1.0	0.997643864188127	4	P20020	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.3912374254073928	0.1805761364091926	0.8567002883170072	1.0	0.997643864188127	4	P20020	1
+EF-hand domain [IPR002048]	0.3174278822519439	0.1730312195099295	0.8626268881078545	1.0	0.997643864188127	40	O95302,Q02818,Q9BRK5,Q96AY3,Q14257,O43852,P80303	7
+Heat shock chaperonin-binding [IPR006636]	0.3847682119205151	0.167931061290689	0.8666375137436555	1.0	0.997643864188127	4	P54727,P54725,P31948	3
+Rhodanese-like domain [IPR001763]	0.4278889371169703	0.1672166609785008	0.8671995754231012	1.0	0.997643864188127	3	P40818	1
+von Willebrand factor, type A [IPR002035]	0.351922541802021	0.1592697146569691	0.8734563803594302	1.0	0.997643864188127	5	Q9NU22	1
+Importin-beta, N-terminal domain [IPR001494]	0.3689804051809913	0.1534373691502722	0.8780533774587997	1.0	0.997643864188127	13	Q96P70,Q14974,Q92973,Q9HAV4,O15397,Q9UIA9,O43592,O14980,Q8TEX9,Q9UI26,O00410,O95373	12
+AP complex, mu/sigma subunit [IPR022775]	0.3408413381914627	0.136291412134081	0.8915909126604826	1.0	0.997643864188127	5	Q96CW1,Q9Y2T2,P53680,P48444	4
+FAD/NAD(P)-binding domain [IPR023753]	0.3659951161637413	0.1345047776824477	0.8930034333765713	1.0	0.997643864188127	4	O95831	1
+PurM-like, C-terminal domain [IPR010918]	0.4021847070506407	0.1283754665947838	0.8978518453156286	1.0	0.997643864188127	3	P22102,P49903	2
+WSTF/Acf1/Cbp146 [IPR013136]	0.554599602911988	0.1236571796045935	0.9015867170840044	1.0	0.997643864188127	2	Q9NRL2	1
+GTP binding domain [IPR006073]	0.3515417892729118	0.1211475730035126	0.903574148831801	1.0	0.997643864188127	11	Q8NC60	1
+NUC153 [IPR012580]	0.5519523494374678	0.1206059884890423	0.9040031253435454	1.0	0.997643864188127	2	Q9BSC4	1
+RecF/RecN/SMC, N-terminal [IPR003395]	0.3240556660039717	0.1062353077807663	0.9153956578853976	1.0	0.997643864188127	6	Q8IY18,Q9NTJ3,Q96SB8,Q9UQE7,O95347	5
+XPC-binding domain [IPR015360]	0.5360688285903472	0.1037624958975878	0.9173578296992252	1.0	0.997643864188127	2	P54725	1
+RAD23A/RAD23B, UBA1 domain [IPR041811]	0.5360688285903472	0.1037624958975878	0.9173578296992252	1.0	0.997643864188127	2	P54725	1
+Bms1/Tsr1-type G domain [IPR030387]	0.5297816015883605	0.0977695208691332	0.922115310223642	1.0	0.997643864188127	2	Q2NL82	1
+AARP2CN [IPR012948]	0.5297816015883605	0.0977695208691332	0.922115310223642	1.0	0.997643864188127	2	Q2NL82	1
+Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]	0.5297816015883605	0.0977695208691332	0.922115310223642	1.0	0.997643864188127	2	Q2NL82	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.5268034414295267	0.0950600057043831	0.924267164993516	1.0	0.997643864188127	2	O00154	1
+ABC-transporter extension domain [IPR032781]	0.5234943745863767	0.0921451563160258	0.9265827114859432	1.0	0.997643864188127	2	Q9UG63	1
+Aminotransferase, class I/classII [IPR004839]	0.3158146026391547	0.0904746418699475	0.927910044151327	1.0	0.997643864188127	6	O15269	1
+Exportin-2, central domain [IPR013713]	0.3677590201919826	0.0888262971294878	0.9292199582067286	1.0	0.997643864188127	3	O15397,O95373	2
+Vps4 oligomerisation, C-terminal [IPR015415]	0.5175380542687065	0.0871476255037988	0.9305541696789356	1.0	0.997643864188127	2	P55072	1
+CARP motif [IPR006599]	0.5036399735274759	0.0766852083066499	0.9388739719487113	1.0	0.997643864188127	2	Q01518	1
+C-CAP/cofactor C-like domain [IPR017901]	0.5036399735274759	0.0766852083066499	0.9388739719487113	1.0	0.997643864188127	2	Q01518	1
+Sec24-like, trunk domain [IPR041742]	0.3402846739490156	0.0666311960907963	0.9468753100352748	1.0	0.997643864188127	3	O95486,O95487	2
+PABP, RNA recognition motif 2 [IPR045305]	0.4718729318332346	0.0584581417443261	0.9533837034936784	1.0	0.997643864188127	2	P11940	1
+CS domain [IPR007052]	0.3115912938139704	0.053918426344437	0.9570001559198658	1.0	0.997643864188127	9	Q15185,Q9UHD1,Q96RS6	3
+Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]	0.4606221045665242	0.0536573116736959	0.9572081941245978	1.0	0.997643864188127	2	Q9H4A3	1
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.4549966909331689	0.0515391507327723	0.9588959055169756	1.0	0.997689030942856	2	P52701	1
+ELMO domain [IPR006816]	0.4427531436135081	0.0475208458837955	0.9620981164896908	1.0	0.9977566421136768	2	Q8IZ81	1
+WW domain [IPR001202]	0.3167061527667504	0.045488883628677	0.9637176353070064	1.0	0.9977566421136768	11	Q13526	1
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.4341495698213175	0.0451392740498535	0.9639962971465874	1.0	0.9977566421136768	2	Q15375	1
+PurM-like, N-terminal domain [IPR016188]	0.4334877564526897	0.0449700146926882	0.9641312095739836	1.0	0.9977566421136768	2	P49903	1
+Cadherin-like [IPR002126]	0.4331568497683754	0.0448861041021575	0.9641980930014408	1.0	0.9977566421136768	2	Q14126	1
+Putative RNA methylase domain [IPR000241]	0.4205823957644074	0.0420338774343304	0.9664716916860752	1.0	0.9977566421136768	2	Q7Z4G4	1
+Domain of unknown function DUF1747 [IPR013719]	0.4136333553937842	0.0407163641458615	0.96752201571165	1.0	0.9977566421136768	2	Q08945	1
+DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	0.9977566421136768	2	Q9H9Y6	1
+RNA polymerase, beta subunit, protrusion [IPR007644]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	0.9977566421136768	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 2 [IPR007642]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	0.9977566421136768	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 7 [IPR007641]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	0.9977566421136768	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 3 [IPR007645]	0.4063534083388573	0.0395113035667575	0.9684827416119648	1.0	0.9977566421136768	2	Q9H9Y6	1
+Dynamin, GTPase domain [IPR001401]	0.2717643164514968	0.0387839863271741	0.9690626122882248	1.0	0.9977566421136768	3	O00429,P50570	2
+STAT transcription factor, all-alpha domain [IPR013800]	0.4007279947055061	0.0386918860187389	0.9691360425859006	1.0	0.9977566421136768	2	P42224	1
+STAT transcription factor, protein interaction [IPR013799]	0.4007279947055061	0.0386918860187389	0.9691360425859006	1.0	0.9977566421136768	2	P42224	1
+STAT transcription factor, DNA-binding [IPR013801]	0.4007279947055061	0.0386918860187389	0.9691360425859006	1.0	0.9977566421136768	2	P42224	1
+Transcription elongation factor S-II, central domain [IPR003618]	0.2628268785170352	0.0371760880706853	0.9703446043848528	1.0	0.9977566421136768	3	Q9BTC0,P23193	2
+Initiation factor eIF-4 gamma, MA3 [IPR003891]	0.2809807819748129	0.0365038110485914	0.9708806399589452	1.0	0.9977566421136768	6	O43432,P78344,Q53EL6,Q04637,Q9HCG8	5
+Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]	0.2713266689590854	0.0362666143646641	0.9710697702957514	1.0	0.9977566421136768	4	O43776	1
+Thioesterase domain [IPR006683]	0.3544010589013964	0.0346956876607718	0.9723223996069276	1.0	0.9977566421136768	2	O00154	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.3431502316346871	0.0342365439858219	0.9726885257255382	1.0	0.9977566421136768	2	P29692	1
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.3431502316346871	0.0342365439858219	0.9726885257255382	1.0	0.9977566421136768	2	P29692	1
+EH domain-containing protein, N-terminal [IPR031692]	0.3246194573130454	0.0337336411800203	0.9730895524485352	1.0	0.9977566421136768	2	Q9H223	1
+Domain of unknown function DUF5600 [IPR040990]	0.3246194573130454	0.0337336411800203	0.9730895524485352	1.0	0.9977566421136768	2	Q9H223	1
+Serine hydroxymethyltransferase-like domain [IPR039429]	0.295830575777639	0.0333492248397284	0.9733960998238312	1.0	0.9977566421136768	2	P34896	1
+Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]	0.294837855724694	0.0333415039030177	0.973402256816055	1.0	0.9977566421136768	2	P00390	1
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.2921087533156542	0.0323621976239893	0.9741832086126664	1.0	0.9981607230763364	8	Q7L5N1,O95630,O00303,P51665,Q92905,Q6P2Q9,O00487	7
+FERM adjacent (FA) [IPR014847]	0.2588048911376567	0.0306005735248659	0.9755880847585434	1.0	0.9992035106197622	4	Q9HCM4	1
+Rab-GTPase-TBC domain [IPR000195]	0.2480953958264376	0.0194428594644164	0.9844878199530582	1.0	1.0	5	Q9Y3P9,Q8TC07,Q9NVG8,Q66K14	4
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.2721246271130217	0.0165336923983071	0.9868086231107572	1.0	1.0	7	Q9H223,O00429,P50570,Q8IWA4,Q9H4M9,O95140	6
+Dynamin, N-terminal [IPR045063]	0.2721246271130217	0.0165336923983071	0.9868086231107572	1.0	1.0	7	Q9H223,O00429,P50570,Q8IWA4,Q9H4M9,O95140	6
+OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]	0.2393130241759937	0.0144583974936817	0.9884642697821908	1.0	1.0	5	O43776	1
+FERM central domain [IPR019748]	0.2823107636036363	0.0101606088649309	0.9918931465477404	1.0	1.0	9	P26038,Q9Y2J2,Q9HCM4,Q96AC1	4
+Band 4.1 domain [IPR019749]	0.2823107636036363	0.0101606088649309	0.9918931465477404	1.0	1.0	9	P26038,Q9Y2J2,Q9HCM4,Q96AC1	4
+Ubiquitin-like domain [IPR000626]	0.3102898275308013	0.009928678199386	0.9920781911092824	1.0	1.0	14	P46379,Q9BZL1,Q8WVY7	3
+MPN domain [IPR037518]	0.2923996017258617	0.005917726792999	0.9952783647150428	1.0	1.0	11	Q7L5N1,Q8TAT6,Q15018,O43402,O95630,O00303,P51665,Q92905,Q6P2Q9,O00487	10

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]"}