diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..86040f08e211d1f4220e9367f56635cace1ab9ea --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:27817bcf087ae7272a6205b441696c51f5708bf516004f2a32b33cd69004875c +size 157536 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..08be70c83ce56f8b06d6f77f196794f9795f1bf9 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dda6f677bb074483d1a21485fdc2679e1ea080c7726f1d4856475a49f8305012 +size 85030 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7df649decda9b4bbe3fb6d8d9d8077bd3b998fbc --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Thiolase, active site [IPR020610] 0 5 2.0987676135046653 0.0358373910812659 2.5606796116504853 4.844660194174757 -0.5308970493980486 0.3952147264399792 1.6528021290928414 0.3622283127413132 1.0786004395841309 0.2880439628871515 0.0242848323540905 0.0471521402185075 0.1145296834007133 0.2203285200495684 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f2134f34bc106f5c8816886c92ad3c55f78fc487 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 54, + "title": "Average number of proteins per term", + "value": 2.537037037037037 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b38925e6ab8e25e1ca79b4ab75779f946a41942f --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..13f791896595181a9aa7b4c6c6de356884a953f0 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,10 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.969877523998676 3.702986935936604 0.0002130758585279 0.0114413663710135 0.0005753048180253 3 Q9HB40,P10619 2 +Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999] 0.8643282594308441 3.62885677042572 0.0002846791234507 0.015257271455856 0.0006405280277642 2 P09622 1 +ATP:guanido phosphotransferase active site [IPR022415] 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.0292500547780865 0.0011414695496397 2 P12532 1 +Tyrosine-protein kinase, active site [IPR008266] 0.5849303667501949 1.8278724957724208 0.0675686897767908 0.977127701550512 0.0829252101806069 3 Q13308 1 +Protein-tyrosine phosphatase, active site [IPR016130] 0.6738643064208468 1.7224077784101548 0.0849956756243357 0.991742474657738 0.1019948107492028 5 Q9Y217,Q06124,P10586 3 +Cysteine peptidase, cysteine active site [IPR000169] 0.6320482510767664 1.5248698261734952 0.1272915692654304 0.999358886002993 0.1432030154236092 5 P53634,O15484 2 +Nucleoside diphosphate kinase, active site [IPR023005] 0.469380999668983 1.1858150865884876 0.2356953322736994 0.9999995029596546 0.2597458763832606 3 P22392,P15531 2 +Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345] 0.4176042356055681 1.1512225838811991 0.2496406764959575 0.9999998161171222 0.2696119306156341 2 Q9NQ88 1 +Serine/threonine-protein kinase, active site [IPR008271] 0.2503940307218549 0.138351125226431 0.8899629218774301 1.0 0.8899629218774301 44 O14976,Q05655,Q13557,Q13555,Q96KB5,P31751,O14965,O15111,Q00535 9 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..17c4954c7c61317728771931164fa74708f786f1 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "MTMR6", "MYLK", "NEK9", "NME1", "NME2", "NME3", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKCD", "PRKD3", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "WNK1"], "leading_proteins": ["AKT2", "AURKA", "CAMK2D", "CAMK2G", "CAPN5", "CDK5", "CHUK", "CKMT1A*", "CTSA", "CTSC", "DLD", "GAK", "MTMR6", "NME1", "NME2", "PBK", "PRKCD", "PTK7", "PTPN11", "PTPRF", "SCPEP1", "TIGAR"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..465c03bba181ece1b3cfc758ab37913f62157507 --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Protein kinase, ATP binding site [IPR017441]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..11f628d126e9c00e8f059ff1927dbf8fd308f17d --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ba13315ffb5719f737d4d5788cadfa131ba9c051b3e63d92320b68a69abbf920 +size 157487 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ce06b0829cacbbe7e49b2d6356dfe8072e2fda7c --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d23077b76076d3eacdddee37e237d6cef3075c1a3dd1cc480f1153bb9e185237 +size 76176 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b455ccbc436234dc625ee36109524678ca54a16c --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 32, + "title": "Average number of proteins per term", + "value": 4.40625 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4d9ac71696d434508e528de3a9cd546ece3f96ad --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0415b06c58406164521ad7c37ff5bdc05ec48af6 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.806750496360028 3.3473866584349574 0.0008157733905993 0.0257773441928187 0.0017403165666119 2 P34896 1 +Peptidase M16, zinc-binding site [IPR001431] 0.7053268585383518 1.8690427499478268 0.0616168669680738 0.8693329235042898 0.0821558226240985 5 Q10713,P22695 2 +Beta tubulin, autoregulation binding site [IPR013838] 0.5946395689336473 1.1317330086018254 0.2577466996457822 0.9999279442912686 0.2945676567380368 6 Q9BUF5,P68371,P07437 3 +Biotin-binding site [IPR001882] 0.3485580265875767 0.3756687493799304 0.7071631733231931 1.0 0.7299748885916832 4 Q96RQ3 1 +Protein kinase, ATP binding site [IPR017441] 0.2442983337953774 0.089233163972778 0.9288966094575386 1.0 0.9288966094575386 40 Q13557,Q13555,P31751,O14965,O15111,O95747,Q00535 7 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3aefe87a16ec0f88e1f50486778986aa7a8032a2 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PPM1L", "PRKCD", "PRKCSH", "PRKD3", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["AKT2", "AURKA", "CAMK2D", "CAMK2G", "CDK5", "CHUK", "MCCC1", "OXSR1", "PMPCA", "SHMT1", "TUBB", "TUBB4B", "TUBB6", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..7613843514c10aa29fdd6a09ecfb7ebd967a05e9 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "WD40 repeat, conserved site [IPR019775]", "1": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "2": "Actinin-type actin-binding domain, conserved site [IPR001589]", "3": "Thioredoxin, conserved site [IPR017937]", "4": "AMP-binding, conserved site [IPR020845]", "5": "Ubiquitin specific protease, conserved site [IPR018200]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..da2c5ad5534b71b4f8ce223b96babf4eaf4cf386 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6b62a8fecbab377d63063dbd9c1a22da5245f3ece7eecf79b9f47e6d1d9d1736 +size 152373 diff --git 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+version https://git-lfs.github.com/spec/v1 +oid sha256:2d3b978858eebc3d8b7d95f73350af4e93eecfe664c2e27799c34fe13978c440 +size 157294 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1734fcfc1a36bd0bebc679af629ebf71c7b31196 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:618aea800bea7cbf770b27c869542ad8eb472b25a6df6e95e2876ac4d22f9efe +size 150800 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..fa5beb3d51644bb9fcad799c88876ff197891cce --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 269, + "title": "Average number of proteins per term", + "value": 2.684014869888476 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3ea63aa191d8600f7ae3b86e29dba23b62364f73 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1d20008806f4a58ad60ed0b59ec1d7fbf029e13b --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,38 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Haem oxygenase conserved site [IPR018207] 0.9523494374586376 4.040667548439278 5.329927025776726e-05 0.0142355878134197 0.0003069868360465 2 P30519 1 +Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0212348051024742 0.0003699511417134 2 P05067 1 +Proteinase inhibitor I2, Kunitz, conserved site [IPR020901] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0212348051024742 0.0003699511417134 2 P05067 1 +Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0212348051024742 0.0003699511417134 2 P05067 1 +DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.8395102581072166 3.508767148886812 0.0004501888576373 0.1140795075142035 0.0013589949863001 2 P09884 1 +Sterol reductase, conserved site [IPR018083] 0.8325612177366022 3.474810994707884 0.0005112134053559 0.1285105922493611 0.0014629404897953 2 Q14739 1 +Sulfatase, conserved site [IPR024607] 0.8173395102581114 3.3999138725344857 0.0006740708182622 0.1658868301387238 0.0018132505011253 2 P15586 1 +RNA polymerase, beta subunit, conserved site [IPR007121] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.2342675846587374 0.0024217115106048 2 Q9H9Y6 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.7855724685638694 3.2412644352430666 0.0011900074015813 0.2740706697038062 0.0026900167313057 2 P40939 1 +Tetraspanin, conserved site [IPR018503] 0.7266710787557968 2.9383294450910165 0.0032998616532973 0.5889870666063811 0.0064323390198331 2 O60637 1 +Mitogen-activated protein (MAP) kinase, conserved site [IPR003527] 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9217418927808544 0.0152753964118646 2 P28482 1 +Ribosomal protein S9, conserved site [IPR020574] 0.6035737921906099 2.265453860470463 0.0234848423512923 0.9983264141030168 0.0331253460560909 2 P82933 1 +Bromodomain, conserved site [IPR018359] 0.6262011482185093 1.6715728256306 0.0946085870268014 0.9999999999975512 0.117822731065785 10 P25440,Q9NRL2,Q86U86,Q9UIG0 4 +DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514] 0.4996690933156957 1.6543620515802937 0.0980539720854791 0.9999999999991218 0.121550776456193 2 P19387 1 +Proteasome beta-type subunit, conserved site [IPR016050] 0.666396318018264 1.6410484958800653 0.1007873487543384 0.999999999999612 0.1243660404353993 8 P28074,P49721 2 +Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.6476832738134719 1.599044910724546 0.1098106239389977 0.9999999999999742 0.1348815426465315 5 P42356,O00443,P78527 3 +Dynamin, GTPase region, conserved site [IPR019762] 0.480807412309738 1.5397384533988487 0.1236241195750913 0.9999999999999996 0.1511585825713617 2 P50570 1 +Ribosomal protein L13, conserved site [IPR023563] 0.4672402382528225 1.4567748190513798 0.1451785489704313 1.0 0.1751256936011033 2 P40429 1 +Mini-chromosome maintenance, conserved site [IPR018525] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2609530413336455 6 P33991,Q14566 2 +WD40 repeat, conserved site [IPR019775] 0.3549027735857787 1.2205330299304324 0.2222628762391227 1.0 0.2610860860625503 51 Q9NV06,Q9BQ67,Q8WUA4,Q05048,Q9BZH6,P43034,Q8TEQ6,O75530,P63244,Q8NFH4,P61964,Q8NFH3,O43818,O75083,Q14137,Q9UFC0,P62873,Q96DI7 18 +Fructose-bisphosphate aldolase class-I active site [IPR029768] 0.4185969556585114 1.1573389257368822 0.2471339159090615 1.0 0.2865475145669722 2 P04075 1 +Tubulin, conserved site [IPR017975] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.2975702240545726 6 Q9BUF5,P68371,P07437 3 +DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.4285911031296866 0.8911871098119428 0.3728287985177005 1.0 0.4161450074741139 15 Q7Z478,Q9H6R0,Q9H2U1,Q08211,Q92620,Q8IX18 6 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.4144775621377699 0.8796998219048028 0.3790219458930015 1.0 0.4195757343424585 3 Q9Y2T2 1 +Actinin-type actin-binding domain, conserved site [IPR001589] 0.4096081423362845 0.7508440866034454 0.4527464935518621 1.0 0.4968818706457933 14 Q01082,P21333,O15020,O75369,Q14315,P46939,Q9UPN3,Q8WXH0 8 +Cyclic nucleotide-binding, conserved site [IPR018488] 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.4968818706457933 2 P10644 1 +EGF-like calcium-binding, conserved site [IPR018097] 0.3315684976836604 0.6353485771304267 0.5252010981201116 1.0 0.5651163815772401 2 Q07954 1 +Ras GTPase-activating protein, conserved site [IPR023152] 0.3445878848063499 0.5134923796470345 0.6076069399436501 1.0 0.6384619798626636 3 Q13576,P46940 2 +Phosphofructokinase, conserved site [IPR015912] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.675919230166982 3 Q01813,P17858 2 +Zinc finger, PHD-type, conserved site [IPR019786] 0.3187093558738896 0.3106142568238592 0.756093887590239 1.0 0.7792691791638862 17 Q9BZ95,O96028,Q9NRL2,Q9UIG0 4 +Enoyl-CoA hydratase/isomerase, conserved site [IPR018376] 0.349301102777628 0.266502487906271 0.7898522435977477 1.0 0.8109551661366189 5 P40939 1 +Chaperonin TCP-1, conserved site [IPR002194] 0.3607551584264743 0.2580521514116813 0.7963666587876246 1.0 0.8145347194443764 8 P49368,P17987,Q99832 3 +Intermediate filament protein, conserved site [IPR018039] 0.3502334792132211 0.2244108706386131 0.8224376128365962 1.0 0.8380140827766832 8 P08670 1 +Thioredoxin, conserved site [IPR017937] 0.2940590773315672 0.135487332159779 0.8922265793767357 1.0 0.90228928515918 11 Q8IXB1,Q9H1E5,P07237,P13667,Q96JJ7,Q9H3N1,Q8NBS9,P30101,O43396,O95881 10 +AMP-binding, conserved site [IPR020845] 0.3005301524188141 0.0778189596252227 0.9379720645827244 1.0 0.944998072557127 6 O95573,Q96CM8,P33121,O60488,Q4G176 5 +Tr-type G domain, conserved site [IPR031157] 0.2345147399801331 0.0263835484689134 0.9789514160029752 1.0 0.982604219794031 5 P13639,P15170,Q96RP9,Q05639 4 +Ubiquitin specific protease, conserved site [IPR018200] 0.229747675962816 0.0096180353345147 0.9923260364169012 1.0 0.9923260364169012 12 Q93008,Q9Y4E8,P54578,P51784,P40818,P45974,Q14694,Q93009,O94966,Q9UPU5,Q86UV5 11 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..963a1143a6461e8d13e7a8d7b5baf2a64b5857ce --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Deoxyribonuclease, TatD-related, conserved site [IPR018228]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamine synthetase, N-terminal conserved site [IPR027302]", "Glutamine synthetase, glycine-rich site [IPR027303]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARIH2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FBXW11", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK2", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GLUL", "GMPPA", "GMPPB", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT1", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IQGAP3", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MIF", "MOCS1", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSD3", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAD18", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RCL1", "RDH13", "RDX", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE1", "SYNE2", "TATDN1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ALDOA", "AP3M1", "APP", "BAZ1A", "BAZ1B", "BOP1", "BRD2", "CCT3", "CCT7", "CSTF1", "DCAF13", "DHX29", "DHX33", "DHX36", "DHX38", "DHX40", "DHX9", "DNAJC10", "DNM2", "EED", "EEF1A2", "EEF2", "FLNA", "FLNB", "FLNC", "GEMIN5", "GFM1", "GNB1", "GNS", "GRWD1", "GSPT1", "GTF3C2", "HADHA", "HMOX2", "IQGAP1", "IQGAP2", "LBR", "LRP1", "LRWD1", "MACF1", "MAPK1", "MCM4", "MCM6", "MRPS9", "NSD2", "NSD3", "NUP37", "NUP43", "P4HB", "PAFAH1B1", "PBRM1", "PDIA3", "PDIA4", "PFKL", "PFKP", "PI4KA", "PIK3C2A", "POLA1", "POLR1B", "POLR2C", "PRKAR1A", "PRKDC", "PSMB2", "PSMB5", "RACK1", 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fc2471d7a7dc444b48cd52bb3713ce6511befae6c670537c28a4c53aa157d31b +size 149854 diff --git a/interpro_domain/basic/plot_9.png b/interpro_domain/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..c418c60f16d5370b1cdbd54e63b21b9d93612875 --- /dev/null +++ b/interpro_domain/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b85f58581896149628574f9502c71546584d2983ea28b618ece024336a4a68a6 +size 150397 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..9cbae3e005553aaf5c8c6347d36f68100c7284e5 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:85933a0ebb6e35698815a623edcb4c99ea07f5af0ccfec7093723e3805459f2a +size 930518 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4d5b58df6772712c10e8a9fd46ee4f4cb9e499b6 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 2 5 2.8515218084297422 0.0043510501462358 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0385773062479974 0.002465796513642 0.0007018811705627 0.0053031795330487 +Aminopeptidase N-like , N-terminal domain [IPR045357] 2 5 2.8515218084297422 0.0043510501462358 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0385773062479974 0.002465796513642 0.0007018811705627 0.0053031795330487 +Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038] 2 5 2.73124292481593 0.0063095944609103 2.9611650485436893 5.067961165048544 -0.667320777745365 0.4263445669465814 1.3998774571686892 0.5789534569272068 0.9506639271252796 0.308773856990838 0.0385773062479974 0.0743799864466655 0.0007018811705627 0.0053031795330487 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 2 6 2.0415535637676965 0.0411958355103989 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0015075035399645 0.0056684159955205 0.0025675639060761 0.0019884945269669 +Peptidase M16, N-terminal [IPR011765] 4 7 1.9704879968101208 0.0487824693050087 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 1.0 1.0 0.0111508905617615 0.0001708540892308 +Peptidase M16, C-terminal [IPR007863] 4 7 1.9704879968101208 0.0487824693050087 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 1.0 1.0 0.0111508905617615 0.0001708540892308 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7f75bff304e36c8a6fd98f8f318ebf0e75ec1a81 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 2581, + "title": "Average number of proteins per term", + "value": 2.143355288647811 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f1fd0cfba70189862f7a52b863a4090320080404 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..326af694d1c7e6efcb75c67e1d1dd899a7067179 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,278 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +GMP phosphodiesterase, delta subunit [IPR008015] 0.9768365320979492 4.151558062283546 3.302194619059229e-05 0.0816999136895166 0.0002244834103331 2 A6NIH7 1 +FAD-binding domain, PCMH-type [IPR016166] 0.961614824619458 4.082805851174227 4.449519443916472e-05 0.1084953732857969 0.0002719300102899 2 Q15392 1 +FAD linked oxidase, N-terminal [IPR006094] 0.961614824619458 4.082805851174227 4.449519443916472e-05 0.1084953732857969 0.0002719300102899 2 Q15392 1 +Saposin B type domain [IPR008139] 0.9569821310390478 4.061764299224246 4.870323731553938e-05 0.1181260232465672 0.0002896383767544 2 P07602 1 +Oxidoreductase, N-terminal domain [IPR041694] 0.9387822634017224 3.978563324901519 6.93329461842751e-05 0.1638560886055473 0.0003644570565742 2 Q14914 1 +Amyloidogenic glycoprotein, heparin-binding [IPR015849] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Beta-amyloid precursor protein C-terminal [IPR019543] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Amyloidogenic glycoprotein, extracellular [IPR008154] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Amyloidogenic glycoprotein, copper-binding [IPR011178] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Pancreatic trypsin inhibitor Kunitz domain [IPR002223] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Amyloidogenic glycoprotein, E2 domain [IPR024329] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.186116432921453 0.0003799441799303 2 P05067 1 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.9212442091330256 3.897561565748908 9.716612498866796e-05 0.2218204157267392 0.0004243414020232 2 O15254 1 +Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543] 0.8825281270681699 3.715774770667619 0.0002025819808015 0.407211177745749 0.0006990161663755 2 Q13555 1 +ERAP1-like C-terminal domain [IPR024571] 0.964912280701754 3.681384798988032 0.0002319705976547 0.4505214632797801 0.0007755390058898 3 Q9NZ08,P55786 2 +Far upstream element-binding protein, C-terminal [IPR015096] 0.8696227663798823 3.654240794354927 0.0002579441038466 0.4861580804898497 0.0008448072207354 2 Q92945 1 +Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099] 0.8643282594308441 3.62885677042572 0.0002846791234507 0.520428087725584 0.0009116089548714 2 P09622 1 +Tim10-like [IPR004217] 0.952002648129758 3.6249429648034504 0.000289025230723 0.5257790581983023 0.0009231689288532 3 Q9Y5L4,Q9Y5J9 2 +WSTF/Acf1/Cbp146 [IPR013136] 0.8434811383189946 3.528105019837679 0.0004185460656254 0.660572033350759 0.0012165173371387 2 Q9UIG0 1 +Acyl transferase [IPR014043] 0.8408338848444744 3.5152183907261008 0.0004393924913932 0.6783596376261906 0.0012671195757385 2 Q8IVS2 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8295830575777645 3.4602133168194613 0.0005397476231836 0.7517861755442496 0.001485012517784 2 O43390 1 +ATP:guanido phosphotransferase, N-terminal [IPR022413] 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.7580195602290323 0.0014994803773808 2 P12532 1 +ATP:guanido phosphotransferase, catalytic domain [IPR022414] 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.7580195602290323 0.0014994803773808 2 P12532 1 +Extracellular Endonuclease, subunit A [IPR020821] 0.8236267372600965 3.43093630642714 0.000601501814746 0.7883758129065941 0.0016121248015156 2 O94919 1 +DNA/RNA non-specific endonuclease [IPR001604] 0.8236267372600965 3.43093630642714 0.000601501814746 0.7883758129065941 0.0016121248015156 2 O94919 1 +Sulfatase, N-terminal [IPR000917] 0.8173395102581114 3.3999138725344857 0.0006740708182622 0.8245433740049812 0.0017626917750098 2 P15586 1 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.8907646474677133 3.3515881783631163 0.0008034944603307 0.8743999717203236 0.0020036900503514 3 Q9NRF9,Q9NRG0 2 +Serine hydroxymethyltransferase-like domain [IPR039429] 0.806750496360028 3.3473866584349574 0.0008157733905993 0.8783211884948074 0.0020245299241701 2 P34896 1 +Protein phosphatase 1 binding domain [IPR029334] 0.806088682991398 3.3440919958396096 0.0008255235777332 0.8813475088130889 0.0020447949655753 2 Q69YH5 1 +RNA polymerase, beta subunit, protrusion [IPR007644] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.922777683376568 0.0023186563086089 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 [IPR007642] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.922777683376568 0.0023186563086089 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 7 [IPR007641] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.922777683376568 0.0023186563086089 2 Q9H9Y6 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.922777683376568 0.0023186563086089 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 3 [IPR007645] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.922777683376568 0.0023186563086089 2 Q9H9Y6 1 +Glycoside hydrolase family 2, catalytic domain [IPR006103] 0.7951687624090025 3.289529184931714 0.0010035514852502 0.925089928854669 0.0023440419759554 2 P08236 1 +Putative RNA methylase domain [IPR000241] 0.7885506287227023 3.2562749877777986 0.0011288436475251 0.9458063297014244 0.002582930367254 2 Q7Z4G4 1 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.7855724685638694 3.2412644352430666 0.0011900074015813 0.9537289162662784 0.0026942185118258 2 P40939 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.7855724685638694 3.2412644352430666 0.0011900074015813 0.9537289162662784 0.0026942185118258 2 P40939 1 +Pre-SET domain [IPR007728] 0.7809397749834571 3.217857384745465 0.0012915201744918 0.964405637521292 0.002886072355293 2 Q96KQ7 1 +Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778] 0.854496209125214 3.1851164226788184 0.0014469578362055 0.9761817381398744 0.0031489023400054 3 Q1KMD3 1 +Ribosomal protein L18e/L15P [IPR021131] 0.8541041253762969 3.1832974307089303 0.0014560795782112 0.9767367432511856 0.0031607581088 3 P46776 1 +SKP1 component, POZ domain [IPR016073] 0.7670416942422267 3.1472138344548313 0.0016483436655265 0.98584780006633 0.003489418723975 2 Q15369 1 +Ribosomal protein L2, C-terminal [IPR022669] 0.7647253474520226 3.1353777679691395 0.0017163293652227 0.9881289425037982 0.0035985752166042 2 P62917 1 +Ribosomal Proteins L2, RNA binding domain [IPR022666] 0.7647253474520226 3.1353777679691395 0.0017163293652227 0.9881289425037982 0.0035985752166042 2 P62917 1 +Vicinal oxygen chelate (VOC) domain [IPR037523] 0.7610853739245562 3.116742066740888 0.0018286148632138 0.9911201929015788 0.0038123222632915 2 Q04760 1 +Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520] 0.7567835870284625 3.094660823918369 0.001970380794674 0.9938454870914124 0.0040554647775547 2 Q9HCL2 1 +GPAT/DHAPAT, acyltransferase domain [IPR041728] 0.7567835870284625 3.094660823918369 0.001970380794674 0.9938454870914124 0.0040554647775547 2 Q9HCL2 1 +Major facilitator superfamily domain [IPR020846] 0.8326251280363114 3.0830041218587225 0.0020492231657698 0.9949807342577748 0.0041843710370664 3 Q6NT16 1 +Homeobox domain [IPR001356] 0.7445400397088067 3.031472070540515 0.0024336443377497 0.9981431831088552 0.0047911792797345 2 Q9UPW6 1 +PITH domain [IPR010400] 0.7379219060225055 2.9971032086629137 0.0027255841994215 0.9991276651038776 0.0052109131990423 2 Q9GZP4 1 +Pleckstrin homology domain 9 [IPR041681] 0.7246856386499048 2.927911944862389 0.0034124667419521 0.999852640992075 0.0062288378083299 2 O15020 1 +Pleckstrin homology domain, spectrin-type [IPR001605] 0.7246856386499048 2.927911944862389 0.0034124667419521 0.999852640992075 0.0062288378083299 2 O15020 1 +Acetyl-CoA carboxylase, central domain [IPR013537] 0.7243547319655896 2.926174356409902 0.0034315855445603 0.9998597597856924 0.0062548886232417 2 O00763 1 +Immunoglobulin C1-set [IPR003597] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.999943322281874 0.0068011362571166 3 P10321 1 +MHC class I, alpha chain, C-terminal [IPR010579] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.999943322281874 0.0068011362571166 3 P10321 1 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.999943322281874 0.0068011362571166 3 P10321 1 +MHC class I-like antigen recognition-like [IPR011161] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.999943322281874 0.0068011362571166 3 P10321 1 +DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133] 0.7927838464084723 2.8935353010982277 0.0038093146799056 0.9999472852454871 0.0068276674922475 3 P09884,P28340 2 +DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134] 0.7927838464084723 2.8935353010982277 0.0038093146799056 0.9999472852454871 0.0068276674922475 3 P09884,P28340 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.9292221481309424 2.8515218084297422 0.0043510501462358 0.9999870519169182 0.0076446973638084 5 Q9NZ08,P55786 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.9292221481309424 2.8515218084297422 0.0043510501462358 0.9999870519169182 0.0076446973638084 5 Q9NZ08,P55786 2 +Gamma tubulin complex component, C-terminal [IPR040457] 0.7041694242223742 2.8194525160082575 0.0048105647820619 0.9999960666849914 0.0083609883518531 2 Q96CW5 1 +Gamma tubulin complex component protein, N-terminal [IPR041470] 0.7041694242223742 2.8194525160082575 0.0048105647820619 0.9999960666849914 0.0083609883518531 2 Q96CW5 1 +Peptidase S8/S53 domain [IPR000209] 0.6975512905360737 2.7841465896849185 0.0053668772465642 0.9999990710532836 0.0092223103684303 2 P29144 1 +Sorting nexin, N-terminal [IPR005329] 0.6968894771674436 2.78060735946824 0.0054257316044203 0.9999992026257668 0.009304859316285 2 Q13596 1 +Vps4 oligomerisation, C-terminal [IPR015415] 0.6962276637988136 2.777066554846803 0.0054851945892977 0.9999993166492352 0.0093756869105811 2 P55072 1 +MIT domain [IPR007330] 0.6962276637988136 2.777066554846803 0.0054851945892977 0.9999993166492352 0.0093756869105811 2 Q8N0X7 1 +Fibronectin type II domain [IPR000562] 0.7642275023646855 2.7549018201374724 0.0058709749884509 0.999999748957281 0.0098845312754023 3 P11717 1 +Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038] 0.9004053131304341 2.73124292481593 0.0063095944609103 0.9999999196325434 0.0104794487153215 5 P55769,P62888 2 +Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333] 0.6869622766379933 2.727329441538783 0.0063849256576236 0.999999933915282 0.010563777642517 2 P00387 1 +Tyrosine-specific protein phosphatase, PTPase domain [IPR000242] 0.7531596638368682 2.7005191797534343 0.0069231345104223 0.999999983677977 0.0113118266792818 3 P10586 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.7521381651984695 2.695481431105871 0.0070286995263286 0.9999999875945244 0.0114382556604377 3 Q10472 1 +NOPS [IPR012975] 0.7464415756372025 2.6673297206466215 0.007645662181005 0.999999997505752 0.0122568037820956 3 Q15233,P23246 2 +FAD/NAD(P)-binding domain [IPR023753] 0.8166838137384256 2.6585573298855985 0.0078475997780436 0.9999999985249124 0.0124951604115549 4 O95831 1 +NSD, Cys-His rich domain [IPR041306] 0.7382936467804335 2.6268931695110327 0.0086168382034665 0.9999999998007444 0.0136137781978083 3 O96028 1 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.6671078755790923 2.6196984862191295 0.0088007540750256 0.999999999876563 0.0138589055934357 2 Q96CP7 1 +Serine-threonine protein phosphatase, N-terminal [IPR031675] 0.6604897418927923 2.583499893354696 0.0097803497345219 0.9999999999903816 0.015206676304097 2 P62140 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.7252565375703345 2.561772285438608 0.0104139573881822 0.9999999999981564 0.0159800380611762 3 P35611,Q9UEY8 2 +PIN domain [IPR002716] 0.7108493013957973 2.4892019033016863 0.0128030234521667 0.9999999999999964 0.0190130054833385 3 Q9ULX3 1 +Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040] 0.6360026472534812 2.4481516361057416 0.0143591210234155 1.0 0.0208558758364859 2 Q9Y678 1 +Coatomer subunit gamma, C-terminal [IPR032154] 0.6360026472534812 2.4481516361057416 0.0143591210234155 1.0 0.0208558758364859 2 Q9Y678 1 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.6971201588877818 2.4194519163931862 0.0155439156125765 1.0 0.0222388282683259 3 Q9UNH7,Q13596 2 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.6964004885356148 2.415779608417495 0.0157015619261358 1.0 0.0224394968612162 3 P61289 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.6964004885356148 2.415779608417495 0.0157015619261358 1.0 0.0224394968612162 3 P61289 1 +Zinc finger, CHHC-type [IPR012996] 0.6918238993710559 2.392388841739716 0.016739097727783 1.0 0.0237905348212599 3 P31943,P52597 2 +Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263] 0.6855345911949655 2.3601386228316423 0.018268107265488 1.0 0.025652875327652 3 P42356,O00443 2 +Extended PHD (ePHD) domain [IPR034732] 0.7518060760074589 2.3577422841203406 0.0183864526128383 1.0 0.0257769876120237 4 Q8IWS0,Q9UGU0 2 +Amine oxidase [IPR002937] 0.6812313803376364 2.3380020832117605 0.0193871400771863 1.0 0.0270038901992541 3 P50336,Q8NB78 2 +Thiamine pyrophosphate enzyme, central domain [IPR012000] 0.6141628060886902 2.32554409096458 0.0200428851596181 1.0 0.0275250882410037 2 A1L0T0 1 +Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766] 0.6141628060886902 2.32554409096458 0.0200428851596181 1.0 0.0275250882410037 2 A1L0T0 1 +Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001] 0.6141628060886902 2.32554409096458 0.0200428851596181 1.0 0.0275250882410037 2 A1L0T0 1 +Dynein heavy chain, linker [IPR013602] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, tail [IPR013594] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain AAA lid domain [IPR041658] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain region D6 P-loop domain [IPR004273] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, coiled coil stalk [IPR024743] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, AAA module D4 [IPR024317] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, C-terminal domain [IPR041228] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +Dynein heavy chain, ATP-binding dynein motor region [IPR035706] 0.6118464592984851 2.312435288157407 0.0207537075917687 1.0 0.0282219806608825 2 Q8NCM8 1 +TRIAD supradomain [IPR044066] 0.6091992058239653 2.2974291499981017 0.021594300470618 1.0 0.0292007929162162 2 Q9Y4X5 1 +IBR domain [IPR002867] 0.6091992058239653 2.2974291499981017 0.021594300470618 1.0 0.0292007929162162 2 Q9Y4X5 1 +Ariadne domain [IPR045840] 0.6091992058239653 2.2974291499981017 0.021594300470618 1.0 0.0292007929162162 2 Q9Y4X5 1 +ELM2 domain [IPR000949] 0.60820648577102 2.29179507163858 0.02191747120589 1.0 0.0295399442205755 2 Q13330 1 +Metastasis-associated protein MTA1, R1 domain [IPR035170] 0.60820648577102 2.29179507163858 0.02191747120589 1.0 0.0295399442205755 2 Q13330 1 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.6078755790867044 2.289916224316834 0.0220261735341789 1.0 0.0296709571459894 2 Q8WUM0 1 +NOP5, N-terminal [IPR012974] 0.6075446724023901 2.288036966440818 0.0221353684577931 1.0 0.0298024966038415 2 Q9Y2X3 1 +Glycosyltransferase 2-like [IPR001173] 0.7364243432997657 2.2848270330452825 0.0223229718811448 1.0 0.0299733257212738 4 Q10472 1 +PTB/PI domain [IPR006020] 0.6058901389808146 2.2786345198155913 0.022688800144643 1.0 0.0303733367081554 2 Q9Y3P9 1 +Domain of unknown function DUF3517 [IPR021905] 0.5976174718729396 2.231468506475968 0.0256501113934495 1.0 0.0338115104731834 2 Q9UPU5 1 +YjeF N-terminal domain [IPR004443] 0.5969556585043096 2.2276841670268994 0.0259015835638096 1.0 0.0340733879603428 2 Q96F86 1 +Zinc finger, CXXC-type [IPR002857] 0.6583371236579338 2.219266190134075 0.0264686203392634 1.0 0.0346955353456774 3 P26358 1 +DDT domain [IPR018501] 0.7217414300782143 2.2146532951199025 0.0267838709123648 1.0 0.0350198433762987 4 Q9NRL2,Q9UIG0 2 +WHIM2 domain [IPR028941] 0.7217414300782143 2.2146532951199025 0.0267838709123648 1.0 0.0350198433762987 4 Q9NRL2,Q9UIG0 2 +Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211] 0.5943084050297894 2.2125304540543795 0.0269300343573541 1.0 0.0351753130953093 2 P09960 1 +CAP Gly-rich domain [IPR000938] 0.656405163853024 2.209172484071448 0.0271626459930898 1.0 0.0352827324147784 3 Q99426,Q15813 2 +WHIM1 domain [IPR028942] 0.7181613582124617 2.1974588353325633 0.0279876933076781 1.0 0.0362631708971472 4 Q9UIG0 1 +Pyruvate carboxyltransferase [IPR000891] 0.5853739245532842 2.161193930521852 0.0306803620724704 1.0 0.0392532582895012 2 P35914 1 +Guanine nucleotide exchange factor, N-terminal [IPR032691] 0.5790866975512989 2.1248907221674425 0.0335957323133548 1.0 0.04267253203778 2 Q92538 1 +Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375] 0.7009630800984568 2.114400774221921 0.0344810515967644 1.0 0.0435612306271409 4 P48147 1 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8010960970300951 2.0415535637676965 0.0411958355103989 1.0 0.0504873938520131 6 Q8WUJ1,Q9UMX5 2 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.5635340833884931 2.034464387249952 0.0419047957351179 1.0 0.051258899427649 2 P52701 1 +Tyrosine-specific protein phosphatases domain [IPR000387] 0.6726119507022186 1.9758512183726633 0.0481716305162067 1.0 0.0579361502154378 4 Q06124,P10586 2 +FAD-binding domain, ferredoxin reductase-type [IPR017927] 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.0583080675328976 3 Q9UHQ9,P00387 2 +Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709] 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.0583080675328976 3 Q9UHQ9,P00387 2 +Oxidoreductase FAD/NAD(P)-binding [IPR001433] 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.0583080675328976 3 Q9UHQ9,P00387 2 +Peptidase M16, N-terminal [IPR011765] 0.7608307393700363 1.9704879968101212 0.0487824693050087 1.0 0.0585344273715609 7 P31930,Q10713,Q5JRX3,P22695 4 +Peptidase M16, C-terminal [IPR007863] 0.7608307393700363 1.9704879968101212 0.0487824693050087 1.0 0.0585344273715609 7 P31930,Q10713,Q5JRX3,P22695 4 +Bromo adjacent homology (BAH) domain [IPR001025] 0.6665424207766208 1.9459321959693696 0.0516628848887124 1.0 0.0619330728740207 4 P26358 1 +Sulphate adenylyltransferase catalytic domain [IPR024951] 0.5479814692256876 1.9431655607360925 0.051996157733368 1.0 0.0622458641511238 2 O95340 1 +Sulphate adenylyltransferase [IPR002650] 0.5479814692256876 1.9431655607360925 0.051996157733368 1.0 0.0622458641511238 2 O95340 1 +ATP-sulfurylase PUA-like domain [IPR025980] 0.5479814692256876 1.9431655607360925 0.051996157733368 1.0 0.0622458641511238 2 O95340 1 +AWS domain [IPR006560] 0.66193189667984 1.9231458122795684 0.0544617402859708 1.0 0.0651370489703849 4 Q9BZ95,O96028 2 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.5971321216898817 1.894016669887549 0.0582227972464486 1.0 0.0696030753557591 3 Q7L576 1 +G-protein, beta subunit [IPR001632] 0.5954981794107942 1.8851832275420304 0.0594051044740673 1.0 0.0709507518035945 3 Q13112,P62873 2 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.7083553493733556 1.8830565084531472 0.0596927103414182 1.0 0.0712612790893618 5 Q9HD20,P05023 2 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.6473548728479427 1.8507718449421873 0.0642023831716218 1.0 0.0763975799750834 4 P14866 1 +SPRY domain [IPR003877] 0.7062966574763258 1.8301896367872823 0.0672215868916781 1.0 0.0798430353278514 8 Q1KMD3,P19474 2 +B30.2/SPRY domain [IPR001870] 0.7062966574763258 1.8301896367872823 0.0672215868916781 1.0 0.0798430353278514 8 Q1KMD3,P19474 2 +Protein-tyrosine phosphatase, catalytic [IPR003595] 0.6921644917858457 1.8079264736378973 0.0706179448276702 1.0 0.0836461292336929 5 Q9Y217,P10586 2 +Exportin-2, central domain [IPR013713] 0.5809334657398184 1.8061174244742193 0.070899999649689 1.0 0.0839416968329575 3 O95373,O15397 2 +Alcohol dehydrogenase-like, C-terminal [IPR013149] 0.7115205281864388 1.748457300355457 0.080384873256873 1.0 0.0947799716199129 7 Q14914,Q8N4Q0 2 +Ricin B, lectin domain [IPR000772] 0.678291789028119 1.743154177085562 0.0813066872224497 1.0 0.09564838638156 5 Q10472 1 +RNA polymerase Rpb1, domain 3 [IPR007066] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +RNA polymerase, alpha subunit [IPR000722] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +RNA polymerase Rpb1, domain 5 [IPR007081] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +RNA polymerase, N-terminal [IPR006592] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +RNA polymerase Rpb1, domain 4 [IPR007083] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +RNA polymerase Rpb1, domain 1 [IPR007080] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0998703697209923 3 O95602,O14802 2 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.1015867221377188 3 P20585,P52701 2 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.1015867221377188 3 P20585,P52701 2 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.1015867221377188 3 P20585,P52701 2 +DNA mismatch repair protein MutS, core [IPR007696] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.1015867221377188 3 P20585,P52701 2 +Helicase/UvrB, N-terminal [IPR006935] 0.5622018203231891 1.7036065178616462 0.0884546229816998 1.0 0.1033505576802929 3 P19447 1 +Rhodanese-like domain [IPR001763] 0.5577623303541868 1.6791827039519869 0.0931164417578473 1.0 0.1086990213374057 3 P40818,P25325 2 +DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263] 0.4996690933156957 1.6543620515802937 0.0980539720854791 1.0 0.1142561182630346 2 P19387 1 +DNA-directed RNA polymerase, insert domain [IPR011262] 0.4996690933156957 1.6543620515802937 0.0980539720854791 1.0 0.1142561182630346 2 P19387 1 +Class I myosin, motor domain [IPR036072] 0.5463980613885214 1.616453496055907 0.105996300130799 1.0 0.1232326354223389 3 O43795 1 +Class I myosin tail homology domain [IPR010926] 0.5463980613885214 1.616453496055907 0.105996300130799 1.0 0.1232326354223389 3 O43795 1 +Ras-associating (RA) domain [IPR000159] 0.5910622040814528 1.5669655719714 0.1171227391199982 1.0 0.1353150356619138 4 Q9Y4G8 1 +GTPase effector domain [IPR020850] 0.480807412309738 1.5397384533988487 0.1236241195750913 1.0 0.1422531665730319 2 P50570 1 +Dynamin GTPase effector [IPR003130] 0.480807412309738 1.5397384533988487 0.1236241195750913 1.0 0.1422531665730319 2 P50570 1 +Dynamin stalk domain [IPR000375] 0.480807412309738 1.5397384533988487 0.1236241195750913 1.0 0.1422531665730319 2 P50570 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.5850773700649639 1.536440776747146 0.1244303123500052 1.0 0.143117039293834 4 P08670 1 +Aldehyde dehydrogenase domain [IPR015590] 0.5758783843460288 1.530977528897323 0.1257749464124939 1.0 0.1445991700181055 11 P30837 1 +Post-SET domain [IPR003616] 0.6779181378251928 1.5044178274959514 0.1324738168204962 1.0 0.1520336365975699 6 Q03164,Q9BZ95,O96028,Q15047 4 +CBS domain [IPR000644] 0.5788079470198565 1.5044046867294274 0.132477198259564 1.0 0.1520336365975699 4 P12268,P51790,Q6P4Q7 3 +SUI1 domain [IPR001950] 0.4728656518861795 1.4912206011838185 0.1359035866409723 1.0 0.1554818958866798 2 O43583 1 +SWIB/MDM2 domain [IPR003121] 0.4728656518861795 1.4912206011838185 0.1359035866409723 1.0 0.1554818958866798 2 Q96GM5 1 +Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763] 0.5739127125816212 1.4793508758299017 0.1390465620554166 1.0 0.1587960958694824 4 O00763 1 +Acetyl-CoA carboxylase [IPR034733] 0.5739127125816212 1.4793508758299017 0.1390465620554166 1.0 0.1587960958694824 4 O00763 1 +Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762] 0.5739127125816212 1.4793508758299017 0.1390465620554166 1.0 0.1587960958694824 4 O00763 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.6464984488678387 1.449669597662524 0.1471506776617852 1.0 0.1675323771702989 7 Q8N4Q0 1 +Phospholipid/glycerol acyltransferase [IPR002123] 0.6630406591217434 1.4381164642609032 0.150401011883269 1.0 0.1711574125532263 6 O15228,Q6UWP7,Q99943,Q9HCL2 4 +Protein of unknown function DUF3504 [IPR021893] 0.5102926482801603 1.4154495388876258 0.1569367336150726 1.0 0.1776551357282906 3 Q5VZL5 1 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.5594291157833514 1.405044343103199 0.160008092713479 1.0 0.1808147492528412 4 P05023 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.5594291157833514 1.405044343103199 0.160008092713479 1.0 0.1808147492528412 4 P05023 1 +EF hand associated, type-1 [IPR013566] 0.4510258107213855 1.3571881913341075 0.1747214218784001 1.0 0.1967521770803449 2 Q8IXI1 1 +EF hand associated, type-2 [IPR013567] 0.4510258107213855 1.3571881913341075 0.1747214218784001 1.0 0.1967521770803449 2 Q8IXI1 1 +MIRO domain [IPR020860] 0.4510258107213855 1.3571881913341075 0.1747214218784001 1.0 0.1967521770803449 2 Q8IXI1 1 +PABP, RNA recognition motif 2 [IPR045305] 0.4500330906684436 1.351079184990764 0.1766700684252211 1.0 0.1988597673813762 2 P11940 1 +VHS domain [IPR002014] 0.440436796823306 1.2919760615032263 0.196365434840305 1.0 0.2202604030086167 2 Q92783 1 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.4397749834546748 1.2878973404595455 0.1977817014070302 1.0 0.2217526374159622 2 P13674 1 +Importin-beta, N-terminal domain [IPR001494] 0.4999662343949013 1.260865743594656 0.2073572222010486 1.0 0.231884311308885 13 Q9HAV4,O14980,O00410,Q9UI26,Q9UIA9,Q92973,O15397,Q8TEX9 8 +Rab-GTPase-TBC domain [IPR000195] 0.575687313680038 1.2553325978609693 0.2093580462730511 1.0 0.2339190984548679 5 O60343,Q9Y3P9,Q9NVG8,Q66K14 4 +Dynamin, GTPase domain [IPR001401] 0.480966567361808 1.2509155895267692 0.2109652755224582 1.0 0.2356128845190241 3 O60313,P50570 2 +ELMO domain [IPR006816] 0.430509596293852 1.2307760627827893 0.2184066306603984 1.0 0.2437127167031942 2 Q96JJ3 1 +MCM N-terminal domain [IPR027925] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2463808224125346 6 P33991,Q14566 2 +MCM domain [IPR001208] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2463808224125346 6 P33991,Q14566 2 +MCM OB domain [IPR033762] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2463808224125346 6 P33991,Q14566 2 +MCM, AAA-lid domain [IPR041562] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2463808224125346 6 P33991,Q14566 2 +SET domain [IPR001214] 0.5577690298252151 1.20733851102301 0.227301805265387 1.0 0.252873258357743 9 Q03164,Q9BZ95,O96028,Q96KQ7 4 +Matrin/U1-C, C2H2-type zinc finger [IPR000690] 0.5625515515350029 1.1922930443400015 0.2331463609264368 1.0 0.2591519197033305 5 Q15428 1 +Nucleoside diphosphate kinase-like domain [IPR034907] 0.469380999668983 1.1858150865884876 0.2356953322736994 1.0 0.2617597472454467 3 P22392,P15531 2 +Glutaredoxin [IPR002109] 0.420582395764401 1.1695738918658594 0.2421724890432108 1.0 0.2684910628095048 2 Q86SX6 1 +Glutaredoxin, PICOT-like [IPR033658] 0.420582395764401 1.1695738918658594 0.2421724890432108 1.0 0.2684910628095048 2 Q86SX6 1 +Domain of unknown function DUF1605 [IPR011709] 0.4805117923901567 1.1446544012874489 0.2523523473587601 1.0 0.2788190961185616 13 Q7Z478,Q9H6R0,Q9H2U1,Q08211,Q92620,Q8IX18 6 +Helicase-associated domain [IPR007502] 0.4805117923901567 1.1446544012874489 0.2523523473587601 1.0 0.2788190961185616 13 Q7Z478,Q9H6R0,Q9H2U1,Q08211,Q92620,Q8IX18 6 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.2844139511696297 6 Q9BUF5,P68371,P07437 3 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.2844139511696297 6 Q9BUF5,P68371,P07437 3 +Bromodomain [IPR001487] 0.4595601926445614 1.1185918273755522 0.2633143116211394 1.0 0.2901854134475494 16 Q03164,P25440,Q9NPI1,Q9UIG0,Q86U86,Q9NRL2 6 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.4547473567700399 1.103674247823479 0.2697344704833195 1.0 0.2965011364214002 3 Q86UV5 1 +LSM domain, eukaryotic/archaea-type [IPR001163] 0.5150413646892906 1.085189937041649 0.2778375401963577 1.0 0.3048888993396256 10 P62316,P62310,Q9Y333,P62318 4 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.4501820589208867 1.078094027801863 0.2809917965666924 1.0 0.3076961505891528 3 O95071,P11940 2 +Zinc finger, RanBP2-type [IPR001876] 0.5288351424804683 1.061017906494366 0.288681763515868 1.0 0.3159828802521015 9 Q92804,O95218,P98175 3 +Tudor domain [IPR002999] 0.5434776755118269 1.047222612180069 0.2949969185810641 1.0 0.3224849838448651 8 Q9Y2W6,Q12888,Q92667,Q14739 4 +Ras GTPase-activating domain [IPR001936] 0.4881487798113153 1.0380135318562378 0.2992637552337112 1.0 0.3268725147093561 4 Q14C86 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.4399205561072482 1.0207240255031196 0.3073852083763015 1.0 0.3353175075313754 3 P13674,Q32P28 2 +Calponin homology domain [IPR001715] 0.3889955655408196 1.018354525808241 0.3085095046696771 1.0 0.3364017877281101 26 Q15417,P21333,Q01082,Q96ED9,O15020,Q13576,Q5M775,O75369,Q14315,P46939,Q9UPN3,Q8WXH0,Q69YQ0 13 +Zinc finger, MYM-type [IPR010507] 0.4797124032742889 0.9948233676919838 0.3198221789900302 1.0 0.3481489008744276 4 Q5VZL5 1 +EGF-like domain [IPR000742] 0.4347161848068877 0.9917138933026188 0.3213371117589978 1.0 0.349650541926633 3 P11047 1 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.4341490565952129 0.988556795549662 0.3228800334362265 1.0 0.3510334314654173 3 Q93009 1 +EF-hand, Ca insensitive [IPR014837] 0.4298326444779236 0.964557903026638 0.3347662931995925 1.0 0.3633439035946796 3 Q13813 1 +4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896] 0.4223766964581211 0.923242716197132 0.3558807327193316 1.0 0.3852886623945448 3 P21912,P61221 2 +Gelsolin-like domain [IPR007123] 0.5392353426749821 0.8854836889787991 0.3758958130139369 1.0 0.4053881755415928 6 O95425,O95487 2 +Alpha/beta hydrolase fold-1 [IPR000073] 0.5365868225011028 0.8738637241970636 0.3821924720465528 1.0 0.4115305675228005 6 Q9NUJ1 1 +Ubiquitin-like domain, USP-type [IPR028135] 0.3719391131700926 0.8722176627856107 0.3830896455630954 1.0 0.4123245934938904 2 Q9Y4E8 1 +Amidohydrolase-related [IPR006680] 0.4070302150896215 0.8389042288652772 0.4015230545508601 1.0 0.4309068622851434 3 P27708 1 +Ubiquitin system component CUE [IPR003892] 0.4374620388755617 0.7817125056243788 0.4343835505453191 1.0 0.4646265826595394 4 Q9H1I8 1 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.4744949623090809 0.7753759416080708 0.4381175470260425 1.0 0.4682324591611659 5 P27695 1 +cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.4852296521105166 2 P10644 1 +Zinc finger, PHD-type [IPR001965] 0.3640668144724784 0.7407341189054303 0.4588546677241094 1.0 0.4897865580628314 23 Q03164,Q9BZ95,O96028,Q9UGU0,Q9UIG0,Q8IWS0,Q9NRL2 7 +Domain of unknown function DUF4217 [IPR025313] 0.3876133009148098 0.7340400725354238 0.4629243155273166 1.0 0.4937221728826463 3 Q8NHQ9 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.5013096266035133 0.7214032388243056 0.4706614544654015 1.0 0.5017667137444037 6 Q9Y4I1,P35580 2 +Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479] 0.5001454100825291 0.7164610368169428 0.4737067179529139 1.0 0.5045963842494722 6 O00763,P27708,Q96RQ3 3 +B-box, C-terminal [IPR003649] 0.3800066203243942 0.6936918247497253 0.4878754939981997 1.0 0.5194746905979181 3 Q13263,O15164 2 +Myosin tail [IPR002928] 0.4179810569147422 0.6863432620011019 0.4924966741344461 1.0 0.5241789344086619 4 P35580 1 +Ku70/Ku80 beta-barrel domain [IPR006164] 0.3342157511581806 0.6503899904868689 0.5154403412489366 1.0 0.5465700578321714 2 P13010 1 +Ku70/Ku80, N-terminal alpha/beta [IPR005161] 0.3342157511581806 0.6503899904868689 0.5154403412489366 1.0 0.5465700578321714 2 P13010 1 +Ku70/Ku80 C-terminal arm [IPR005160] 0.3342157511581806 0.6503899904868689 0.5154403412489366 1.0 0.5465700578321714 2 P13010 1 +EGF-like calcium-binding domain [IPR001881] 0.3315684976836604 0.6353485771304267 0.5252010981201116 1.0 0.55669159517372 2 Q07954 1 +Clp ATPase, C-terminal [IPR019489] 0.3312375909993455 0.6334745012294241 0.5264238271184434 1.0 0.5577585787326365 2 Q9H078 1 +Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 0.466958382102336 0.6281920864425677 0.5298781137588251 1.0 0.5609579210875831 7 Q9UBF8,P42356,O00443,P78527 4 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059] 0.3292521508934553 0.6222593027623046 0.5337713770397512 1.0 0.5648478573758089 2 P47897 1 +Biotin carboxylase, C-terminal [IPR005482] 0.4381780463722373 0.611900972107206 0.5406032784189496 1.0 0.5709071446805682 5 O00763,Q96RQ3 2 +Biotin carboxylation domain [IPR011764] 0.4381780463722373 0.611900972107206 0.5406032784189496 1.0 0.5709071446805682 5 O00763,Q96RQ3 2 +Biotin carboxylase-like, N-terminal domain [IPR005481] 0.4381780463722373 0.611900972107206 0.5406032784189496 1.0 0.5709071446805682 5 O00763,Q96RQ3 2 +Myosin head, motor domain [IPR001609] 0.4359833319873458 0.6069327952919087 0.5438955127644114 1.0 0.5732112366047145 9 Q9Y4I1,P35580 2 +Glutamine amidotransferase type 2 domain [IPR017932] 0.3624823215825624 0.6027517119456324 0.5466738746278292 1.0 0.5759041920058887 3 P08243 1 +Mu homology domain [IPR028565] 0.399622145197025 0.59902730632356 0.5491546755276935 1.0 0.5782816065022346 4 Q9Y2T2 1 +Immunoglobulin-like domain [IPR007110] 0.4036945315638287 0.5913968920809815 0.5542545222990802 1.0 0.5831794237440563 11 P10321,P10586 2 +Phox homology [IPR001683] 0.4324054461961361 0.5904317852093648 0.5549012061827621 1.0 0.5836185872688301 9 O00443,Q9UNH7,Q13596,Q96L92,Q9UMY4,Q9Y5X1 6 +Zinc finger, UBR-type [IPR003126] 0.3902326934419596 0.5555657597605135 0.5785077440496353 1.0 0.6077039020724904 4 Q8IWV8 1 +BRCT domain [IPR001357] 0.4062298513392762 0.5327833154506512 0.5941835846868615 1.0 0.6231563722376227 10 P09874,Q14676,O00541,Q12888,Q9NYB0 5 +RasGAP protein, C-terminal [IPR000593] 0.3445878848063499 0.5134923796470345 0.6076069399436501 1.0 0.6367168136396918 3 Q13576,P46940 2 +Zinc finger, RING-type [IPR001841] 0.3305153100166696 0.5082696299987033 0.6112642653707823 1.0 0.6402893948547034 23 Q96T51,O96028,P19474 3 +Exportin-1/Importin-beta-like [IPR013598] 0.3747117425979231 0.4858515093736145 0.6270724506894105 1.0 0.65551802155908 4 Q9HAV4,Q9Y5L0 2 +Peptidase M20, dimerisation domain [IPR011650] 0.3021178027796241 0.4748655557144766 0.6348828034900738 1.0 0.6631454940541807 2 Q8IYS1 1 +Phosphofructokinase domain [IPR000023] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.6739683992271506 3 Q01813,P17858 2 +Formin, GTPase-binding domain [IPR010473] 0.3595093364066494 0.4205689843353606 0.6740698459024834 1.0 0.7001103711365432 4 O60879 1 +Formin, FH3 domain [IPR010472] 0.3595093364066494 0.4205689843353606 0.6740698459024834 1.0 0.7001103711365432 4 O60879 1 +von Willebrand factor, type A [IPR002035] 0.3865267530089877 0.3986543899851313 0.6901478792316744 1.0 0.7150829692079291 5 Q9NU22 1 +Zinc finger, CCHC-type [IPR001878] 0.3969066929900493 0.3879263921647606 0.6980705064526587 1.0 0.7224218031893793 8 Q7Z6E9,Q6NZY4,Q9NUD5 3 +Zinc finger, FYVE-related [IPR017455] 0.3808017378339168 0.3769557790226996 0.7062064680564324 1.0 0.7293793093451989 5 Q96T51,Q7Z3T8 2 +FYVE zinc finger [IPR000306] 0.3808017378339168 0.3769557790226996 0.7062064680564324 1.0 0.7293793093451989 5 Q96T51,Q7Z3T8 2 +K Homology domain, type 1 [IPR004088] 0.3032802169435375 0.3530300755477856 0.7240658933256805 1.0 0.746928085800792 24 Q9Y2W6,Q15365,Q96PU8,Q15366,Q92945 5 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.305254899523151 0.3350178522095213 0.7376116195112574 1.0 0.7593839608929219 3 O60884 1 +K Homology domain [IPR004087] 0.2955256964899246 0.3061814667450993 0.7594664826193176 1.0 0.7793968157616138 24 Q9Y2W6,Q15365,Q96PU8,Q15366,Q92945 5 +U2A'/phosphoprotein 32 family A, C-terminal [IPR003603] 0.2793776895067753 0.2353042009799761 0.8139726347445786 1.0 0.8323547425815203 3 P39687,P09661 2 +Intermediate filament, rod domain [IPR039008] 0.3502334792132211 0.2244108706386131 0.8224376128365962 1.0 0.8403450034565537 8 P08670 1 +Zinc finger, CCCH-type [IPR000571] 0.2990009860851224 0.2186170264951288 0.8269483883906479 1.0 0.8442855183687745 17 Q9UGR2,Q9P2N5,Q8IWR0 3 +AMP-binding enzyme, C-terminal domain [IPR025110] 0.3003311258278047 0.2042784909903237 0.8381358772749878 1.0 0.8533446545352046 4 Q96CM8,Q4G176,P33121 3 +JmjC domain [IPR003347] 0.2972748519385517 0.1950819905822723 0.8453287611447837 1.0 0.8603286800136778 4 Q9H6W3 1 +Zinc finger, PHD-finger [IPR019787] 0.2785178132858208 0.183022511227055 0.8547803555432605 1.0 0.8692624498255144 21 Q03164,Q9BZ95,O96028,Q9UIG0,Q9NRL2 5 +Glutamine amidotransferase [IPR017926] 0.2914374547354693 0.1781241814480998 0.8586254516545815 1.0 0.872828787207749 4 P17812 1 +Zinc finger C2H2-type [IPR013087] 0.2825586476718184 0.1716170342043994 0.8637386147871613 1.0 0.8769903087197731 19 P98175,Q96ME7,Q7Z2T5,Q92766,Q96KR1,O95785,Q9UKJ3 7 +PDZ domain [IPR001478] 0.2749724186423822 0.152150459340575 0.8790682666528067 1.0 0.89185345763793 20 Q53GG5 1 +TRASH domain [IPR011017] 0.3288797781784586 0.1318480951228733 0.8951044441787017 1.0 0.9066972411401998 6 P83731,Q5VZL5 2 +DZF domain [IPR006561] 0.2615894039735025 0.1043213494404498 0.9169143359470908 1.0 0.9247971477449948 4 Q12906,Q96SI9,Q96KR1 3 +AMP-dependent synthetase/ligase [IPR000873] 0.3006297646668791 0.0852502582311599 0.9320624356825172 1.0 0.9371457524334152 7 O95573,Q9P265,Q96CM8,P33121,O60488,Q4G176 6 +Brix domain [IPR007109] 0.2580324610798333 0.0536954747657481 0.9571777882162942 1.0 0.9601538559604568 5 Q9NQ55,Q8TDN6,Q9H7B2,Q96G21 4 +LIS1 homology motif [IPR006594] 0.2544360147746692 0.0253067181378737 0.9798103153494316 1.0 0.9820933685114108 9 Q9H7D7,O95684 2 +Protein kinase domain [IPR000719] 0.218282487532494 0.0171253798371545 0.9863365916976023 1.0 0.9882054208286124 53 O14976,Q05655,Q13557,Q13555,Q96KB5,P31751,O14965,O15111,O95747,Q00535 10 +TOG domain [IPR034085] 0.2499070683306858 0.0167025497882969 0.9866739130086536 1.0 0.9882054208286124 6 O00410,Q8TEX9 2 +Proteasome alpha-subunit, N-terminal domain [IPR000426] 0.2491287936686466 0.0154816370471413 0.9876479342521912 1.0 0.9887972530275042 7 P60900 1 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.2298239787445936 0.0066229884582539 0.9947156583948508 1.0 0.9951012070996552 13 Q93008,Q9Y4E8,P54578,P51784,P40818,P45974,Q14694,Q93009,O94966,Q9UPU5,Q53GS9,Q86UV5 12 +Ubiquitin specific protease domain [IPR028889] 0.2298239787445936 0.0066229884582539 0.9947156583948508 1.0 0.9951012070996552 13 Q93008,Q9Y4E8,P54578,P51784,P40818,P45974,Q14694,Q93009,O94966,Q9UPU5,Q53GS9,Q86UV5 12 +Translation elongation factor EFTu-like, domain 2 [IPR004161] 0.2348258706467609 0.0033062729353175 0.997361980677336 1.0 0.997361980677336 9 O60841,Q05639,P41091,Q96RP9,P13639,Q9Y450,P15170,Q15029 8 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a4c75704b4c59569a84ff86690fa9f10c07c5607 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADD domain [IPR025766]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ATF7-interacting protein , protein binding domain [IPR031870]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "ATRX, ADD domain [IPR041430]", "AWS domain [IPR006560]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein Cbl, EF hand-like [IPR014741]", "Adaptor protein Cbl, N-terminal helical [IPR003153]", "Adaptor protein Cbl, PTB domain [IPR024159]", "Adaptor protein Cbl, SH2-like domain [IPR014742]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Argonaute hook domain [IPR019486]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-mannosidase, Ig-fold domain [IPR041625]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Bud22 domain [IPR015158]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRAL/TRIO, N-terminal domain [IPR011074]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CUT domain [IPR003350]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain C2 domain [IPR033884]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cation/H+ exchanger [IPR006153]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein H, C-terminal [IPR008426]", "Centrosomal CEP44 domain [IPR029157]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class V myosin, motor domain [IPR036103]", "Class VI myosin, motor domain [IPR036114]", "Class XVIII myosin, motor domain [IPR036064]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Clusterin, C-terminal [IPR016015]", "Clusterin, N-terminal [IPR016014]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin II complex subunit H2, N-terminal [IPR009378]", "Condensin II complex subunit H2, middle domain [IPR031719]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Condensin-2 complex subunit H2, C-terminal [IPR031737]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic fatty-acid binding [IPR000463]", "D domain of beta-TrCP [IPR021977]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA mismatch repair protein family, N-terminal [IPR002099]", "DNA mismatch repair protein, S5 domain 2-like [IPR013507]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA recombination and repair protein RecA, monomer-monomer interface [IPR020587]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding protein SMUBP-2, R3H domain [IPR034072]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA/RNA-binding protein Alba-like [IPR002775]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxycytidylate deaminase domain [IPR035105]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "DhaK domain [IPR004006]", "DhaL domain [IPR004007]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dienelactone hydrolase [IPR002925]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dip2-like domain [IPR037337]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homolog subfamily C member 16, TRX domain [IPR043361]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4195 [IPR025243]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4371 [IPR025398]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-binding protein, first C-terminal SH3 domain [IPR035820]", "Dynamin-binding protein, first N-terminal SH3 domain [IPR035817]", "Dynamin-binding protein, second N-terminal SH3 domain [IPR035818]", "Dynamin-binding protein, third N-terminal SH3 domain [IPR035819]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass [IPR039520]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELK domain [IPR005539]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXOG, C-terminal [IPR041003]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst complex component Sec3, C-terminal [IPR019160]", "Exocyst complex component Sec3, PIP2-binding N-terminal domain [IPR028258]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM3C (ILEI) domain [IPR039475]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-butyrobetaine hydroxylase-like, N-terminal [IPR010376]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Germinal-centre associated nuclear protein, CID domain [IPR031910]", "Germinal-centre associated nuclear protein, MCM3AP domain [IPR031907]", "Germinal-centre associated nuclear protein, nucleoporin homology domain [IPR031908]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine synthetase, beta-Grasp domain [IPR008147]", "Glutamine synthetase, catalytic domain [IPR008146]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgin subfamily A, conserved domain [IPR043976]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HAT, C-terminal dimerisation domain [IPR008906]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HOOK, N-terminal [IPR043936]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock factor (HSF)-type, DNA-binding [IPR000232]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hook, C-terminal [IPR008636]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxyacylglutathione hydrolase, C-terminal domain [IPR032282]", "Hydroxyacylglutathione hydrolase, MBL domain [IPR035680]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISG20, DEDDh 3'-5' exonuclease domain [IPR037433]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Initiation factor eIF2 gamma, C-terminal [IPR015256]", "Initiation factor eIF2 gamma, GTP-binding domain [IPR044128]", "Initiation factor eIF2 gamma, domain 2 [IPR044127]", "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain [IPR040464]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Inositol-tetrakisphosphate 1-kinase, N-terminal [IPR041429]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Interferon-related developmental regulator, C-terminal [IPR006921]", "Interferon-related developmental regulator, N-terminal [IPR007701]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intersectin-2, fifth SH3 domain [IPR035741]", "Intersectin-2, first SH3 domain [IPR035737]", "Intersectin-2, fourth SH3 domain [IPR035740]", "Intersectin-2, second SH3 domain [IPR035738]", "Intersectin-2, third SH3 domain [IPR035739]", "Intimal thickness related receptor, IRP [IPR019336]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV [IPR000034]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MCM3AP, RNA recognition motif [IPR034265]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "MYND-like zinc finger [IPR031615]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "Mannosidase Ig/CBM-like domain [IPR041447]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Mediator complex, subunit Med25, NR box [IPR021406]", "Mediator complex, subunit Med25, PTOV domain [IPR021394]", "Mediator complex, subunit Med25, synapsin 1 [IPR021397]", "Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain [IPR021419]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondria fission protein Fis1, cytosolic domain [IPR033745]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MoaB/Mog domain [IPR001453]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdenum cofactor synthesis C-terminal [IPR010505]", "Molybdopterin cofactor biosynthesis C (MoaC) domain [IPR002820]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin 5a, cargo-binding domain [IPR037988]", "Myosin Light Chain Kinase 1, Kinase domain [IPR015725]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-CoR, GPS2-interacting domain [IPR031557]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "NACHT nucleoside triphosphatase [IPR007111]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NEMO, Zinc finger [IPR034735]", "NET domain [IPR027353]", "NF-kappa-B essential modulator NEMO, CC2-LZ domain [IPR032419]", "NF-kappa-B essential modulator NEMO, N-terminal [IPR021063]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, N-terminal [IPR002871]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Neurexin/syndecan/glycophorin C [IPR003585]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear hormone receptor, ligand-binding domain [IPR000536]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear speckle splicing regulatory protein 1, N-terminal [IPR018612]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 3, p23 domain [IPR037905]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Orc1-like, AAA ATPase domain [IPR041664]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain [IPR019601]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PHR [IPR012983]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKCBP1, PHD finger [IPR044075]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentrin/AKAP-450 centrosomal targeting domain [IPR019528]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Plus-3 domain [IPR004343]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain [IPR039558]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein furry, C-terminal [IPR045842]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM15B, RNA recognition motif 1 [IPR034475]", "RBM15B, RNA recognition motif 2 [IPR034535]", "RBM15B, RNA recognition motif 3 [IPR034536]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM8, RNA recognition motif [IPR033744]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad18, zinc finger UBZ4-type [IPR006642]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Regulator of G protein signalling-like domain [IPR015212]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "RmlD-like substrate binding domain [IPR029903]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rubisco LSMT, substrate-binding domain [IPR015353]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SATB, CUT1-like DNA-binding domain [IPR032355]", "SATB, ubiquitin-like oligomerisation domain [IPR032392]", "SCAF4, RNA recognition motif [IPR034369]", "SCAF8, RNA recognition motif [IPR034370]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SEPARIN core domain [IPR030397]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SETD3, SET domain [IPR044428]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLC41A/MgtE, integral membrane domain [IPR006667]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm3 [IPR034105]", "Sm-like protein Lsm4 [IPR034101]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TFIIF beta subunit, HTH domain [IPR040450]", "TFIIF, beta subunit, N-terminal [IPR040504]", "TGS [IPR004095]", "THADA/TRM732, DUF2428 [IPR019442]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TNRC6, PABC binding domain [IPR032226]", "TNRC6B, RNA recognition motif [IPR034925]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "TauD/TfdA-like domain [IPR003819]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thg1 C-terminal domain [IPR025845]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "Toll/interleukin-1 receptor homology (TIR) domain [IPR000157]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tuberin, N-terminal [IPR024584]", "Tuberin-type domain [IPR018515]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone C, N-terminal [IPR031925]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glucuronate decarboxylase N-terminal [IPR021761]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate heat shock transcription factor, C-terminal domain [IPR010542]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Villin headpiece [IPR003128]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZMYND8/11, PWWP domain [IPR035505]", "ZN598/Hel2, RING finger [IPR041888]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, AN1-type [IPR000058]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc finger, nuclear hormone receptor-type [IPR001628]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p115RhoGEF, RGS domain [IPR037887]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNAHis guanylyltransferase catalytic domain [IPR024956]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMCX3", "ARMT1", "ARSA", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAP18", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCKDHA", "BCS1L", "BIRC6", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C11orf58", "C1orf35", "C2CD5", "CACUL1", "CACYBP", "CAD", "CADM1", "CALM3", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CD2AP", "CD2BP2", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLU", "CLUH", "CMBL", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNPY2", "COASY", "COG4", "COIL", "COLEC12", "COMMD4", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CROT", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CWF19L1", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCTD", "DCTN1", "DCUN1D5", "DDB1", "DDHD2", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC2H1", "EARS2", "EBP", "ECE1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERI1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAM208A", "FAM3C", "FAM49B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO22", "FBXW11", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPR180", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS3", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS11", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "ISG20L2", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPK1", "ITSN2", "IVD", "IWS1", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8A", "LRRC8C", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LZIC", "MACF1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED25", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPHOSPH8", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS10", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH2", "NCBP1", "NCKIPSD", "NCL", "NCLN", "NCOR1", "NCSTN", "NDUFA10", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NEMF", "NENF", "NES", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT21", "NUDT5", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PDZD8", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR3A", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PWP2", "PXN", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCL1", "RCN1", "RCN2", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOX1", "RIPK1", "RNASEH2A", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPP25L", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRP12", "RSF1", "RSL24D1", "RTCA", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCAF8", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STOM", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCC", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THADA", "THG1L", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIMM13", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TKFC", "TKT", "TLCD1", "TLN1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMLHE", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOP1", "TOP2A", "TOP2B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSR1", "TSTA3", "TTC4", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UACA", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "UXS1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13C", "VPS18", "VPS29", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASF2", "WASHC4", "WDHD1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "WNK1", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YBX3", "YKT6", "YME1L1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF598", "ZNF638", "ZPR1", "ZRANB2", "ZYX"], "leading_proteins": ["ABCE1", "ABHD10", "ACACB", "ACOX3", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ADD1", "ADD3", "AGPAT1", "AIFM1", "AKAP1", "AKT2", "ALDH1B1", "ANP32A", "AP3M1", "APEX1", "APP", "ARIH1", "ASCC2", "ASNS", "ATP13A1", "ATP1A1", "AURKA", "BAZ1A", "BAZ1B", "BRD2", "BRD7", "BRIX1", "CAD", "CAMK2D", "CAMK2G", "CDCA2", "CDK5", "CHAF1B", "CHRAC1", "CHUK", "CKMT1A*", "CLCN3", "CLPB", "CNN3", "CNNM4", "COPG1", "CTPS1", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "DDX55", "DENR", "DHCR24", "DHX29", "DHX33", "DHX36", "DHX38", "DHX40", "DHX9", "DIAPH2", "DIP2B", "DLD", "DNAJA2", "DNM2", "DNMT1", "DYNC2H1", "EDC3", "EEF1A2", "EEF2", "EFTUD2", "EHMT2", "EIF2S3", "EIF5B", "ELMO2", "ELOC", "ENDOD1", "ERAP1", "ERCC3", "FGFR1OP", "FLNA", "FLNB", "FLNC", "GAK", "GALNT1", "GAPVD1", "GBF1", "GFM1", "GLO1", "GLRX5", "GNB1", "GNPAT", "GNS", "GPAM", "GPATCH8", "GSPT1", "GUSB", "HADHA", "HBS1L", "HLA-C", "HMGCL", "HNRNPF", "HNRNPH1", "HNRNPL", "HNRNPR", "HNRNPUL2", "HOOK2", "IGF2R", "ILF3", "ILVBL", "IMP4", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IQGAP1", "IQGAP2", "KDM1B", "KHSRP", "KMT2A", "LAMC1", "LBR", "LCLAT1", "LRP1", "LSM2", "LSM3", "LTA4H", "MACF1", "MCAT", "MCCC1", "MCM4", "MCM6", "MDC1", "MDN1", "MPST", "MSH3", "MSH6", "MTA1", "MTMR6", "MYH10", "MYO1B", "MYO5A", "NENF", "NME1", "NME2", "NOB1", "NONO", "NOP58", "NPEPPS", "NSD2", "NSD3", "NUP133", "OPA1", "OXSR1", "P3H1", "P4HA1", "PABPC1", "PAPSS2", "PARP1", "PBK", "PBRM1", "PCBP1", "PCBP2", "PDLIM3", "PES1", "PFKL", "PFKP", "PHF6", "PI4KA", "PI4KB", "PIK3C2A", "PITHD1", "PITRM1", "PM20D2", "PMPCA", "POLA1", "POLD1", "POLE3", "POLR1A", "POLR1B", "POLR2C", "POLR3A", "PPAN", "PPOX", "PPP1CB", "PREP", "PRKAR1A", "PRKCD", "PRKDC", "PSAP", "PSMA6", "PSME3", "PTGR1", "PTPN11", "PTPRF", "QARS", "QKI", "RABGAP1", "RAPGEF2", "RBBP6", "RBM10", "RBM27", "RHOT2", "RIOX1", "RPF2", "RPL24", "RPL27A", "RPL30", "RPL8", "RREB1", "RUFY1", "SATB2", "SDHB", "SEC24B", "SETDB1", "SF3A2", "SFPQ", "SHMT1", "SLC18B1", "SMARCD1", "SNRPA1", "SNRPD2", "SNRPD3", "SNU13", "SNX1", "SNX12", "SNX27", "SNX6", "SNX9", "SPART", "SPECC1", "SPECC1L", "SPTAN1", "SPTBN1", "SPTBN2", "STAM", "STRBP", "SVIL", "SYNE2", "TAF15", "TBC1D13", "TBC1D4", "TBC1D9B", "TBCB", "TBCE", "TCF20", "TDRKH", "TERF2IP", "TIMM13", "TIMM8B", "TLCD1", "TNPO1", "TNPO3", "TP53BP1", "TPP2", "TRIM21", "TRIM24", "TRIM28", "TRMT11", "TRMT1L", "TUBB", "TUBB4B", "TUBB6", "TUBGCP3", "UBR2", "UBR5", "UNC119B", "UQCRC1", "UQCRC2", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VCP", "VIM", "WDR26", "WIZ", "XPO1", "XPO5", "XPO7", "XRCC5", "ZADH2", "ZC3H7A", "ZC3H7B", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM4", "ZNF512", "ZRANB2"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..beaeca5447667ffab8f65059f8afcab97852f7ef --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6f0b091daa04844e94258178422950edf439b940cb521b4a0f8f35dbf89734fb +size 931212 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9c4e139c1f491794f5fc0d77b9f7e18af22fda0e --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 2 5 2.8515218084297422 0.0043510501462358 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0385773062479974 0.002465796513642 0.0007018811705627 0.0053031795330487 +Thiolase [IPR002155] 0 5 2.0987676135046653 0.0358373910812659 2.5606796116504853 4.844660194174757 -0.5308970493980486 0.3952147264399792 1.6528021290928414 0.3622283127413132 1.0786004395841309 0.2880439628871515 0.0242848323540905 0.0471521402185075 0.1145296834007133 0.2203285200495684 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7bf44210a9dfd3f25ff1ddcb6d2a2b8d1a900f6f --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 2324, + "title": "Average number of proteins per term", + "value": 1.2719449225473323 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..27b76ea0325a8af5d5636aa6b3b81a620d1827d6 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a9f2f2d93fb4151410a304175736e1018b927d7f --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,113 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +CD36 family [IPR002159] 0.997021839841165 4.24183705318662 2.2169763287172017e-05 0.050218291207012 0.0001218468376667 2 Q8WTV0 1 +Mpv17/PMP22 [IPR007248] 0.996360026472535 4.238892966463531 2.246247151038716e-05 0.0508641786338475 0.0001227526679633 2 Q567V2 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9884182660489744 4.20348039125825 2.6284193152870117e-05 0.0592569786181886 0.000133372194077 2 Q99595 1 +Haem oxygenase [IPR002051] 0.9523494374586376 4.040667548439278 5.329927025776726e-05 0.1165060236804817 0.0002071362944465 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.9523494374586376 4.040667548439278 5.329927025776726e-05 0.1165060236804817 0.0002071362944465 2 P30519 1 +Medium-chain dehydrogenase/reductase [IPR045010] 0.9387822634017224 3.978563324901519 6.93329461842751e-05 0.1488231460233798 0.0002448780652465 2 Q14914 1 +Palmitoyl protein thioesterase [IPR002472] 0.9318332230311062 3.9465664184577434 7.927993643974673e-05 0.16827537806592 0.00026976072077 2 Q9UMR5 1 +Amyloidogenic glycoprotein [IPR008155] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.1692546208828974 0.0002706927539507 2 P05067 1 +Mitochondrial carrier UCP-like [IPR002030] 0.9275314361350112 3.926694452828012 8.612127102125555e-05 0.1813956923773005 0.0002867418823114 2 Q9H2D1 1 +Acyl-CoA oxidase [IPR012258] 0.9212442091330256 3.897561565748908 9.716612498866796e-05 0.2021423220913142 0.0003116927765052 2 O15254 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.9212442091330256 3.897561565748908 9.716612498866796e-05 0.2021423220913142 0.0003116927765052 2 O15254 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.8911317008603603 3.7565331461593567 0.0001722834618358 0.3299622730336317 0.0004759396883908 2 Q93050 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.8911317008603603 3.7565331461593567 0.0001722834618358 0.3299622730336317 0.0004759396883908 2 Q93050 1 +Zinc finger CCCH domain-containing protein A/B [IPR039691] 0.882859033752484 3.717346286104517 0.0002013264046345 0.3737024299137595 0.0005371786043291 2 Q9UGR2 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.969877523998676 3.702986935936604 0.0002130758585279 0.3905760175778486 0.0005608021463407 3 Q9HB40,P10619 2 +Aminopeptidase N-type [IPR034016] 0.964912280701754 3.681384798988032 0.0002319705976547 0.4167633202144686 0.0005976714733367 3 Q9NZ08,P55786 2 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.866975512905364 3.641558986881344 0.0002709920152459 0.4673393795665882 0.0006707454047603 2 Q5VW38 1 +Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100] 0.8643282594308441 3.62885677042572 0.0002846791234507 0.4840206180788275 0.0006978842646619 2 P09622 1 +Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238] 0.952002648129758 3.6249429648034504 0.000289025230723 0.4892074415012393 0.0007055615926474 3 Q9Y5L4,Q9Y5J9 2 +Ribosomal protein L4/L1e [IPR002136] 0.85704831237591 3.593819833210133 0.0003258652073456 0.5311320746676794 0.0007759331371632 2 Q9BYD3 1 +Tropomyosin [IPR000533] 0.9424031777557088 3.5827117289252475 0.0003400457995099 0.5463370837444805 0.0008047519735857 3 P09493,P67936 2 +Sulfotransferase [IPR005331] 0.8444738583719423 3.5329320680010814 0.000410978059836 0.6153068710159213 0.0009414639107041 2 Q7LGA3 1 +Nucleobindin [IPR040250] 0.8381866313699573 3.502310609501716 0.0004612415670424 0.6577359234165434 0.0010302590841916 2 P80303 1 +Villin/Gelsolin [IPR007122] 0.8368630046326966 3.4958487630412165 0.000472556453781 0.6666228229346516 0.0010449297798165 2 O95425 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.8325612177366022 3.474810994707884 0.0005112134053559 0.6952805414437417 0.0011072320168194 2 Q14739 1 +Nonaspanin (TM9SF) [IPR004240] 0.917364282127966 3.471486207575754 0.0005175859194603 0.6997623881986741 0.0011168706377213 3 Q99805 1 +HnRNP R/Q splicing factor [IPR006535] 0.8295830575777645 3.4602133168194613 0.0005397476231836 0.7148420725233129 0.0011539774390789 2 O43390 1 +ATP:guanido phosphotransferase [IPR000749] 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.7212983063151052 0.0011685838512323 2 P12532 1 +Cytoplasmic FMR1-interacting [IPR008081] 0.8239576439444115 3.432565674288256 0.0005978990562069 0.7509079987552434 0.0012529462638638 2 Q7L576 1 +Serine hydroxymethyltransferase [IPR001085] 0.806750496360028 3.3473866584349574 0.0008157733905993 0.8499266456706587 0.0016287434362138 2 P34896 1 +DNA-directed RNA polymerase, subunit 2 [IPR015712] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.9003460519658348 0.0019112005568093 2 Q9H9Y6 1 +Porin, eukaryotic type [IPR001925] 0.8761975927509762 3.2851470767167275 0.001019291492692 0.906523154577449 0.0019496571432233 3 P45880 1 +S-phase kinase-associated protein 1-like [IPR001232] 0.7670416942422267 3.1472138344548313 0.0016483436655265 0.9783751324106004 0.0028886180063492 2 Q15369 1 +Ribosomal protein L2 [IPR002171] 0.7647253474520226 3.1353777679691395 0.0017163293652227 0.981540504329322 0.0029744589446514 2 P62917 1 +Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284] 0.7567835870284625 3.094660823918369 0.001970380794674 0.989782795368041 0.0033405128923495 2 Q9HCL2 1 +Major facilitator superfamily [IPR011701] 0.8326251280363114 3.0830041218587225 0.0020492231657698 0.991496529617241 0.0034535131524648 3 Q6NT16 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.7531436135009959 3.075928039693927 0.0020984848380973 0.9924181872721628 0.0035149556052446 2 O60884 1 +Exocyst complex component EXOC6/Sec15 [IPR007225] 0.7435473196558606 3.0263263097314548 0.0024754499679668 0.9968491343776172 0.0040343237907118 2 Q8TAG9 1 +Exportin 4/7-like [IPR044189] 0.730641958967575 2.95912324086961 0.003085156932832 0.9992390840503652 0.00484868169335 2 Q9C0E2 1 +Actin-related protein 2/3 complex subunit 1 [IPR017383] 0.7289874255459999 2.9504658254139677 0.0031729514396818 0.9993799202916176 0.0049622739877662 2 O15143 1 +Tetraspanin/Peripherin [IPR018499] 0.7266710787557968 2.9383294450910165 0.0032998616532973 0.9995387449923822 0.0051179916024805 2 O60637 1 +Tetraspanin, animals [IPR000301] 0.7266710787557968 2.9383294450910165 0.0032998616532973 0.9995387449923822 0.0051179916024805 2 O60637 1 +Spectrin, beta subunit [IPR016343] 0.7246856386499048 2.927911944862389 0.0034124667419521 0.999645263386889 0.0052590004696928 2 O15020 1 +DNA-directed DNA polymerase, family B [IPR006172] 0.7927838464084723 2.8935353010982277 0.0038093146799056 0.9998594225394256 0.0057937482435214 3 P09884,P28340 2 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.7866516842453182 2.863967517045886 0.0041837091248242 0.9999413155568552 0.0062526945376794 3 Q5TFE4 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.9292221481309424 2.8515218084297422 0.0043510501462358 0.999960289825667 0.0064571140101226 5 Q9NZ08,P55786 2 +Gamma-tubulin complex component protein [IPR007259] 0.7041694242223742 2.8194525160082575 0.0048105647820619 0.9999864175164098 0.0070401464442771 2 Q96CW5 1 +NADH:cytochrome b5 reductase-like [IPR001834] 0.6869622766379933 2.727329441538783 0.0063849256576236 0.999999657207804 0.00896590164853 2 P00387 1 +Exportin-1/5 [IPR045065] 0.6816677696889528 2.6987686089255702 0.0069596548032224 0.9999999106570796 0.0096504998584063 2 Q9HAV4 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.7414636050788623 2.6426489757790277 0.0082260268259957 0.999999995396044 0.0110953490096425 3 Q6P1A2 1 +Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349] 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999999997241 0.0124613630928919 2 P28482 1 +Filamin family [IPR044801] 0.7110228401191633 2.490079831257157 0.012771440498779 0.9999999999998936 0.0161660281694785 3 P21333,Q14315 2 +Torsin-1A-interacting protein 1/2 [IPR008662] 0.6386499007280013 2.4628916836539227 0.0137821544927323 0.99999999999999 0.0172573960350808 2 Q8NFQ8 1 +Coatomer gamma subunit [IPR017106] 0.6360026472534812 2.4481516361057416 0.0143591210234155 0.9999999999999974 0.0178739139038123 2 Q9Y678 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.7695364238410527 2.4410298804028514 0.0146454429333313 0.9999999999999988 0.0181872655619806 4 Q9H0U9,P55209,Q99733 3 +Intracellular chloride channel [IPR002946] 0.6336863004632761 2.4352325804956534 0.0148822205034764 0.9999999999999992 0.0184182188278634 2 O00299 1 +Proteasome activator PA28 [IPR009077] 0.6964004885356148 2.415779608417495 0.0157015619261358 1.0 0.0193173265835572 3 P61289 1 +Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309] 0.6254136333554008 2.388928985984867 0.0168975681801941 1.0 0.0205386759679765 2 O95478 1 +Oligosaccharyl transferase, STT3 subunit [IPR003674] 0.6224354731965657 2.372196862267483 0.0176826664519575 1.0 0.0213478009529088 2 P46977 1 +Phosphatidylinositol kinase [IPR015433] 0.6855345911949655 2.3601386228316423 0.018268107265488 1.0 0.021940610483201 3 P42356,O00443 2 +Ribosomal protein L14P [IPR000218] 0.6201191264063606 2.3591599777182317 0.0183163577320415 1.0 0.0219758468607457 2 P62829 1 +Eukaryotic porin/Tom40 [IPR027246] 0.7458752948130682 2.3297007696871472 0.0198219718436547 1.0 0.0235031951860477 4 P45880 1 +E3 ubiquitin ligase RBR family [IPR031127] 0.6091992058239653 2.2974291499981017 0.021594300470618 1.0 0.02533800868573 2 Q9Y4X5 1 +Mesoderm induction early response protein/metastasis-associated protein [IPR040138] 0.60820648577102 2.29179507163858 0.02191747120589 1.0 0.0256476349861472 2 Q13330 1 +Nucleolar protein Nop56/Nop58 [IPR045056] 0.6075446724023901 2.288036966440818 0.0221353684577931 1.0 0.0258635476600861 2 Q9Y2X3 1 +Ribosomal protein S9 [IPR000754] 0.6035737921906099 2.265453860470463 0.0234848423512923 1.0 0.0271536187186086 2 P82933 1 +Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015] 0.5943084050297894 2.2125304540543795 0.0269300343573541 1.0 0.0306190801597314 2 P09960 1 +Taxilin family [IPR026183] 0.5929847782925294 2.204943792372091 0.027458038986889 1.0 0.0310977010748197 2 P40222 1 +Beta-catenin [IPR013284] 0.5847121111846539 2.157379427656436 0.0309761128143415 1.0 0.034560002967129 2 P35222 1 +Protein arginine N-methyltransferase [IPR025799] 0.6946186834613906 2.083570907496288 0.0371992156014804 1.0 0.0404733038660302 4 Q86X55 1 +E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322] 0.5506287227002078 1.9587663383372076 0.0501401574328261 1.0 0.0530868910587189 2 Q9ULT8 1 +Adenylyl-sulfate kinase [IPR002891] 0.5479814692256876 1.9431655607360925 0.051996157733368 1.0 0.0550018527866852 2 O95340 1 +P-type ATPase [IPR001757] 0.7083553493733556 1.8830565084531472 0.0596927103414182 1.0 0.0630285592155638 5 Q9HD20,P05023 2 +HnRNP-L/PTB [IPR006536] 0.6473548728479427 1.8507718449421873 0.0642023831716218 1.0 0.0676979757218009 4 P14866 1 +DNA-directed RNA polymerase, subunit beta-prime [IPR045867] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.0893177413440566 3 O95602,O14802 2 +DNA mismatch repair MutS family [IPR045076] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.0909769056067578 3 P20585,P52701 2 +Proteasome B-type subunit [IPR023333] 0.6884998575643131 1.643357604507186 0.1003089663371263 1.0 0.104866413750554 7 P28074,P49721 2 +Proteasome, subunit alpha/beta [IPR001353] 0.5504489045370501 1.601442293518507 0.109278991606097 1.0 0.1140900163937868 14 P60900,P28074,P49721 3 +Small GTPase Rho [IPR003578] 0.6907977301969064 1.5616268972342355 0.1183759092647389 1.0 0.1231448581608117 6 P61586,P84095 2 +Ribosomal protein L13 [IPR005822] 0.4672402382528225 1.4567748190513798 0.1451785489704313 1.0 0.1507573493330127 2 P40429 1 +Glutathione S-transferase, Mu class [IPR003081] 0.4533421575115914 1.37143800442488 0.1702384570906017 1.0 0.1759938497680419 2 P28161 1 +Mitochondrial Rho GTPase [IPR021181] 0.4510258107213855 1.3571881913341075 0.1747214218784001 1.0 0.1805480588907967 2 Q8IXI1 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.4500330906684436 1.351079184990764 0.1766700684252211 1.0 0.1824805506756506 2 P11940 1 +Ribosomal protein L37/S30 [IPR010793] 0.4444076770350884 1.316442135605716 0.1880256879230812 1.0 0.1939510424914517 2 Q9BZE1 1 +Prolyl 4-hydroxylase [IPR045054] 0.4397749834546748 1.2878973404595455 0.1977817014070302 1.0 0.2038335583458706 2 P13674 1 +Dynamin [IPR022812] 0.480966567361808 1.2509155895267692 0.2109652755224582 1.0 0.2171316653295806 3 O60313,P50570 2 +Mini-chromosome maintenance protein [IPR031327] 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.2274430205571954 6 P33991,Q14566 2 +Nucleoside diphosphate kinase [IPR001564] 0.469380999668983 1.1858150865884876 0.2356953322736994 1.0 0.2420485869218194 3 P22392,P15531 2 +Monothiol glutaredoxin-related [IPR004480] 0.420582395764401 1.1695738918658594 0.2421724890432108 1.0 0.2484807348946676 2 Q86SX6 1 +Fructose-bisphosphate aldolase, class-I [IPR000741] 0.4185969556585114 1.1573389257368822 0.2471339159090615 1.0 0.2534594971635741 2 P04075 1 +Tubulin [IPR000217] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.2639944160320837 6 Q9BUF5,P68371,P07437 3 +Beta tubulin [IPR002453] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.2639944160320837 6 Q9BUF5,P68371,P07437 3 +Pyridoxal phosphate-dependent decarboxylase [IPR002129] 0.4099933818663226 1.1043648277785054 0.2694349116487591 1.0 0.2754803056188808 2 O95470 1 +Hydantoinase/dihydropyrimidinase [IPR011778] 0.4007279947054987 1.0474407407338422 0.2948963498472294 1.0 0.3008512366307995 2 Q16555 1 +Clathrin adaptor, mu subunit [IPR001392] 0.4144775621377699 0.8796998219048028 0.3790219458930015 1.0 0.3854910294334073 3 Q9Y2T2 1 +Phosphatidylethanolamine-binding protein [IPR008914] 0.3729318332230372 0.8781993198236787 0.3798355610741506 1.0 0.3858119947274152 2 Q96DV4 1 +Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810] 0.3729318332230372 0.8781993198236787 0.3798355610741506 1.0 0.3858119947274152 2 Q96DV4 1 +Bcl-2 family [IPR026298] 0.3570483123759191 0.7832370761168574 0.4334879063633838 1.0 0.4395400935377417 2 Q9BXK5 1 +Bcl2-like [IPR002475] 0.3570483123759191 0.7832370761168574 0.4334879063633838 1.0 0.4395400935377417 2 Q9BXK5 1 +cAMP-dependent protein kinase regulatory subunit [IPR012198] 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.4605407324630848 2 P10644 1 +KH domain-containing BBP-like [IPR045071] 0.4265941361297674 0.7282086544530745 0.4664858688632365 1.0 0.4725863815336362 4 Q96PU8 1 +ADF/Cofilin [IPR017904] 0.3796756041045899 0.6919469420763619 0.488970649703599 1.0 0.4951493637957142 3 P60981,P23528 2 +Peptidase M20 [IPR002933] 0.3021178027796241 0.4748655557144766 0.6348828034900738 1.0 0.6401161107639616 2 Q8IYS1 1 +ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.6502434183402372 3 Q01813,P17858 2 +ATP-dependent 6-phosphofructokinase [IPR022953] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.6502434183402372 3 Q01813,P17858 2 +ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.6502434183402372 3 Q01813,P17858 2 +Chaperone DnaJ [IPR012724] 0.305254899523151 0.3350178522095213 0.7376116195112574 1.0 0.740799223744236 3 O60884 1 +SCAMP [IPR007273] 0.2883151274412373 0.2678909151619138 0.7887832868509055 1.0 0.7908250037280001 3 O14828,O15127 2 +Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998] 0.3607551584264743 0.2580521514116813 0.7963666587876246 1.0 0.7980837063486156 8 P49368,P17987,Q99832 3 +Enoyl-CoA hydratase/isomerase [IPR001753] 0.3469401275990745 0.1739744949122496 0.8618855066507289 1.0 0.862627871428206 6 P40939 1 +Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423] 0.2902648052362229 0.0865810986135116 0.9310044905935276 1.0 0.9314052673867232 9 P49368,P17987,Q99832 3 +Proteasome alpha-type subunit [IPR023332] 0.2491287936686466 0.0154816370471413 0.9876479342521912 1.0 0.9876479342521912 7 P60900 1 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..547152c17f6d8d76bd121fe6d115a216673bce45 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-oxoisovalerate dehydrogenase subunit alpha [IPR034616]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S10, mitochondrial [IPR040055]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L42, mitochondrial [IPR019346]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein S29/30S ribosomal protein S14 type Z [IPR039744]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchor protein 9/Pericentrin [IPR028745]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ADF/Cofilin [IPR017904]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP synthase-coupling factor 6, mitochondrial [IPR008387]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-histidine N-methyltransferase SETD3 [IPR025785]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Activating transcription factor 7-interacting protein [IPR026085]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA oxidase [IPR012258]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein Cbl [IPR024162]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase [IPR011408]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Antifreeze, type III [IPR006013]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Armadillo-type fold containing protein ARMC8/Vid28 [IPR038739]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Band-7 stomatin-like [IPR043202]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Bet3 family [IPR016721]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-adducin [IPR027773]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [IPR013109]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bud22/Serum response factor-binding protein 1 [IPR037393]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC45 family [IPR003874]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK2-associated and cullin domain-containing protein 1 [IPR042652]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGG triplet repeat-binding protein 1 [IPR033375]", "CGI121/TPRKB [IPR013926]", "CHORD domain containing protein [IPR039790]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 4 [IPR037356]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Calcium-transporting ATPase type 2C member 1 [IPR030336]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Carboxymethylenebutenolidase homolog [IPR042946]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation/H+ exchanger, CPA1 family [IPR018422]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc42-interacting protein 4 [IPR028498]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centromere protein H [IPR040034]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Clusterin [IPR016016]", "Clusterin-like [IPR000753]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 51 [IPR037660]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit D3 [IPR012371]", "Condensin-2 complex subunit G2 [IPR024741]", "Condensin-2 complex subunit H2 [IPR031739]", "Conserved oligomeric Golgi complex, subunit 3 [IPR007265]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclin/Cyclin-like subunit Ssn8 [IPR043198]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cys/Met metabolism, pyridoxal phosphate-dependent enzyme [IPR000277]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly protein CtaG/Cox11 [IPR007533]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit VIb [IPR003213]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutL/Mlh/Pms [IPR038973]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair protein XRCC4 [IPR010585]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-binding protein SATB1/SATB2 [IPR039673]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxycytidylate deaminase [IPR016473]", "Deoxycytidylate deaminase-related [IPR015517]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydroxyacetone kinase [IPR012734]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthine synthase [IPR004551]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [IPR039485]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dymeclin [IPR019142]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-binding protein [IPR035469]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RNF213 [IPR031248]", "E3 ubiquitin-protein ligase Rad18 [IPR039577]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Emopamil-binding protein [IPR007905]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin receptor type-A /type-B [IPR016257]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM3 family [IPR039220]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GPCR-associated sorting protein [IPR043374]", "GPI mannosyltransferase [IPR005599]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Gdt1 family [IPR001727]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glu-tRNAGln amidotransferase C subunit [IPR003837]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate acyltransferase, PlsB [IPR028354]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 4 [IPR000715]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor Ect2 [IPR026817]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-binding protein, beta subunit [IPR016346]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HEXIM [IPR024872]", "HIRA-interacting protein 3 [IPR037647]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Heat shock transcription factor family [IPR027725]", "Helicase MOV-10 [IPR026122]", "Helicase SMUBP-2/Hcs1-like [IPR004483]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase EHMT2 [IPR038034]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxyacylglutathione hydrolase [IPR017782]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "IQ calmodulin-binding motif-containing protein 1 [IPR028765]", "ISC system FeS cluster assembly, IscU scaffold [IPR011339]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Inositol-tetrakisphosphate 1-kinase [IPR008656]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 10 [IPR026164]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrator complex subunit 8 [IPR038751]", "Integrator complex subunit 9 [IPR027074]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interferon-related developmental regulator [IPR039777]", "Interferon-stimulated 20kDa exonuclease-like 2 [IPR034933]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intersectin-2 [IPR027029]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper putative tumor suppressor [IPR045329]", "Leucine zipper putative tumour suppressor 2 [IPR028597]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat flightless-interacting protein 1/2 [IPR019139]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Med25/PTOV1 [IPR045105]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med21 [IPR021384]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondria fission 1 protein [IPR016543]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial fission regulator 1 [IPR007972]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit TIM22 [IPR039175]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdenum cofactor biosynthesis C [IPR023045]", "Molybdenum cofactor biosynthesis protein A [IPR013483]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multifunctional methyltransferase subunit Trm112 [IPR039127]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Na+/H+ exchanger [IPR004709]", "Na+/H+ exchanger, isoform 6/7/9 [IPR002090]", "Nck-associated protein 1 [IPR019137]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Non-specific endonuclease [IPR040255]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear hormone receptor [IPR001723]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear speckle splicing regulatory protein 1 [IPR042816]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar and spindle-associated protein 1 [IPR026756]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC domain-containing protein 3 [IPR027761]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "ODR-4-like [IPR029454]", "Oligoribonuclease [IPR022894]", "Oligosaccharide biosynthesis protein Alg14-like [IPR013969]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Origin recognition complex, subunit 2 [IPR007220]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIA, PMR1-type [IPR006413]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PDZ domain-containing protein 8 [IPR039275]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PEX5/PEX5L [IPR024111]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Paxillin [IPR001904]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C50, separase [IPR005314]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 1 [IPR002467]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxin-3 [IPR006966]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal biogenesis factor 11 [IPR008733]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisomal targeting signal 1 receptor PEX5, animals [IPR024113]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polycomb protein EED [IPR037352]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor Isy1 [IPR009360]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein BRICK1 [IPR033378]", "Protein C10 [IPR026317]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM3C [IPR039219]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG3 [IPR030692]", "Protein Nucling [IPR030227]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein SMG8 [IPR028802]", "Protein SON [IPR032922]", "Protein Sec13 [IPR037596]", "Protein Sgt1-like [IPR044563]", "Protein Spindly, chordates [IPR028593]", "Protein TFG [IPR033512]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C mu-related [IPR015727]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF3512 [IPR021900]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein of unknown function DUF842, eukaryotic [IPR008560]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein strawberry notch [IPR026741]", "Protein suppressor of sable-like [IPR045124]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein zyg-11 homologue B [IPR040367]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA methyltransferase [IPR003750]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "Queuosine salvage protein family [IPR019438]", "RAB11-binding protein RELCH [IPR040362]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit Pop5/Rpp14/Rnp2-like [IPR002759]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "RZZ complex, subunit Zwilch [IPR018630]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "Ral GTPase-activating protein subunit beta [IPR039930]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein 3 [IPR013970]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma protein family [IPR028309]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e [IPR023438]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L51, mitochondrial [IPR019373]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12, bacterial-type [IPR005679]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S14 [IPR001209]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21 [IPR001911]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 [IPR000529]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SCAR/WAVE family [IPR028288]", "SERRATE/Ars2 [IPR039727]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SLC41A divalent cation transporter [IPR045349]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "SSNA1 family [IPR033362]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sdc1/DPY30 [IPR037856]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenium-binding protein [IPR008826]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 6 [IPR030644]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 2-like [IPR034893]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP19 subunit [IPR002778]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein F [IPR034100]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smg8/Smg9 [IPR019354]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Spindle and kinetochore-associated protein 1 [IPR009829]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterile alpha and TIR motif-containing protein 1 [IPR039184]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin [IPR028515]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Supervillin [IPR015628]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntaxin-3 [IPR031186]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TE2IP/Rap1 [IPR039595]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM115/Pdh1/Rbl19 [IPR013861]", "TMEM33/Pom33 family [IPR005344]", "TMEM70 family [IPR009724]", "TMEM70/TMEM186/TMEM223 protein family [IPR045325]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPMT family [IPR008854]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "TatD family [IPR001130]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "Tetratricopeptide repeat protein TTC27/Emw1 [IPR044244]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thiopurine S-methyltransferase [IPR025835]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor TFIIB [IPR000812]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor IIF, beta subunit [IPR003196]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription termination factor, mitochondrial/chloroplastic [IPR003690]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 161A/B [IPR019395]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Trimethyllysine dioxygenase [IPR012776]", "Trinucleotide repeat-containing gene 6B protein [IPR033500]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Trm112-like [IPR005651]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "TspO/MBR-related protein [IPR004307]", "Tuberin [IPR003913]", "Tuberin/Ral GTPase-activating protein subunit alpha [IPR027107]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone C [IPR027684]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "U6 snRNA-associated Sm-like protein Lsm3 [IPR040002]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-GlcNAc-dolichyl-phosphate GlcNAc phosphotransferase [IPR033895]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronic acid decarboxylase [IPR044516]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquinol-cytochrome-c reductase complex assembly factor 2 [IPR037698]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised protein family UPF0449 [IPR028227]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Unconventional myosin-XVIIIa [IPR031244]", "Ureohydrolase [IPR006035]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Vma22/CCDC115 [IPR040357]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WASH complex subunit 7 [IPR027307]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WDR48/Bun107 [IPR021772]", "WDR74/Nsa1 [IPR037379]", "WW domain binding protein 11 [IPR019007]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 638 [IPR033096]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA-specific 2-thiouridylase [IPR004506]", "tRNAHis guanylyltransferase Thg1 [IPR007537]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "ALDH16A1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANKLE2", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARG2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMC8", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD3A", "ATAD3B", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD7", "BRI3BP", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUD23", "BUD31", "BYSL", "C11orf58", "C12orf57", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C5orf15", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACUL1", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CDV3", "CEBPZ", "CENPH", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHD8", "CHERP", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA7", "COASY", "COG3", "COIL", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CROT", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTD", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX29", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH5", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FIS1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GCAT", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPR107", "GPRASP2", "GPS1", "GRIPAP1", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP2", "IGHMBP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS3", "INTS7", "INTS8", "INTS9", "IPO4", "IPO5", "IQCB1", "IRS4", "ISCU", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC2", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMF2", "LNPEP", "LONP1", "LPCAT3", "LRPAP1", "LRPPRC", "LRRC47", "LRRFIP1", "LSM12", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LZIC", "LZTS2", "MACF1", "MAGED2", "MAGT1", "MAK16", "MANF", "MAP1B", "MAP1S", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGST3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTERF3", "MTFR1L", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYO18A", "NAA10", "NAA15", "NAA25", "NAA40", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NELFB", "NELFCD", "NES", "NFS1", "NHP2", "NIP7", "NIPBL", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NSA2", "NSF", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUSAP1", "NUTF2", "NXF1", "OAT", "OCIAD1", "ODR4", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PATL1", "PBDC1", "PBRM1", "PC", "PCBD1", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITPNA", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIE", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4R1", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM5", "RBM6", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCA", "RTCB", "RTFDC1", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARS", "SARS2", "SART1", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG5", "SMG8", "SMPD4", "SMS", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPNS1", "SPOUT1", "SPR", "SPTBN1", "SPTBN2", "SQLE", "SRFBP1", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF2", "SRSF6", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STIP1", "STMN1", "STOM", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SURF6", "SVIL", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARS", "TARS2", "TATDN1", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TECR", "TERF2IP", 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score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Alpha/Beta hydrolase fold [IPR029058] 9 24 3.17499202362006 0.0014984062007283 7.793689320388349 25.487864077669904 0.3803730368869525 0.1931612116461074 2.8504230618688027 2.5849355029363217 1.9090082785106757 0.2379814650369476 8.116996873619197e-07 1.3015843029717177e-08 4.828069310507606e-07 1.620623892082362e-05 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 2 5 2.8515218084297422 0.0043510501462358 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 0.0432957136582515 0.0031504918831051 0.0010341818226167 0.0076703518288617 +Peptidase M4/M1, CTD superfamily [IPR027268] 2 5 2.8515218084297422 0.0043510501462358 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 0.0432957136582515 0.0031504918831051 0.0010341818226167 0.0076703518288617 +Mitochondrial carrier domain superfamily [IPR023395] 6 18 2.1961651078722624 0.0280801278117615 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0148056693212618 0.0513963234576887 0.002019433305579 0.0020709532532559 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 13 27 2.135044209388201 0.0327573991166028 9.805825242718448 32.80339805825243 -0.1088315233449008 0.6119304422693201 6.02109278283909 5.726593398203311 0.9050821109811418 0.3248802556462882 1.0 1.0 0.7227235820118948 0.2480543652066013 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 2 6 2.0415535637676965 0.0411958355103989 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0015075035399645 0.0056684159955205 0.0025675639060761 0.0019884945269669 +HAD-like superfamily [IPR036412] 7 15 2.003856606146063 0.0450854230744766 5.905339805825243 19.805825242718445 0.5764874318568468 0.4905542596212732 2.7813998415737995 2.7290535093395536 0.8549369097345116 0.3043048374614219 0.2560754722464486 0.1132051672598368 0.1745567506507994 0.3326328598090462 +HAD superfamily [IPR023214] 7 15 2.003856606146063 0.0450854230744766 5.905339805825243 19.805825242718445 0.5764874318568467 0.4905542596212732 2.7813998415737995 2.7290535093395536 0.8549369097345116 0.3043048374614219 0.2412174988663298 0.1009015630926116 0.1511748617182208 0.2882156922533737 +FAD/NAD(P)-binding domain superfamily [IPR036188] 5 19 2.001567199090979 0.0453312997171371 5.128640776699029 19.483009708737864 1.1388517428876976 0.3148047818604211 2.42568278788952 1.8971625900564304 0.9268276914308484 0.2996934003616133 0.0155575631698287 0.0061250241039257 0.0138407349238781 0.0105883475769395 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 4 7 1.9704879968101208 0.0487824693050087 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 1.0 1.0 0.0111508905617615 0.0001708540892308 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..205737229fcdcba45ccdf62ef133aaa95e8e6b13 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 963, + "title": "Average number of proteins per term", + "value": 4.736240913811007 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0531cbd5584c2034b05050d3293bd7f2af1e0bdf --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2f4becbeea2c9d2f4ad13103d40a842b414d6091 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,168 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.9768365320979492 4.151558062283546 3.302194619059229e-05 0.0313003358428676 0.0002564526950124 2 A6NIH7 1 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.961614824619458 4.082805851174227 4.449519443916472e-05 0.0419447453220182 0.0003127654908388 2 Q15392 1 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.961614824619458 4.082805851174227 4.449519443916472e-05 0.0419447453220182 0.0003127654908388 2 Q15392 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.9523494374586376 4.040667548439278 5.329927025776726e-05 0.0500335066409407 0.0003485897589627 2 P30519 1 +Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0739599171461396 0.000447956742429 2 P05067 1 +Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0739599171461396 0.000447956742429 2 P05067 1 +Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0739599171461396 0.000447956742429 2 P05067 1 +E2 domain superfamily [IPR036176] 0.9315023163467916 3.945039558820974 7.978680570408514e-05 0.0739599171461396 0.000447956742429 2 P05067 1 +Tim10-like domain superfamily [IPR035427] 0.952002648129758 3.6249429648034504 0.000289025230723 0.2429844826862817 0.0011448550111658 3 Q9Y5L4,Q9Y5J9 2 +Ribosomal protein L4 domain superfamily [IPR023574] 0.85704831237591 3.593819833210133 0.0003258652073456 0.2693782064244915 0.0012502318512903 2 Q9BYD3 1 +Malonyl-CoA ACP transacylase, ACP-binding [IPR016036] 0.8408338848444744 3.5152183907261008 0.0004393924913932 0.3450706800323704 0.0015510628851144 2 Q8IVS2 1 +Acyl transferase domain superfamily [IPR001227] 0.8408338848444744 3.5152183907261008 0.0004393924913932 0.3450706800323704 0.0015510628851144 2 Q8IVS2 1 +Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035] 0.8408338848444744 3.5152183907261008 0.0004393924913932 0.3450706800323704 0.0015510628851144 2 Q8IVS2 1 +ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802] 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.4110458101974877 0.001844116310742 2 P12532 1 +His-Me finger superfamily [IPR044925] 0.8236267372600965 3.43093630642714 0.000601501814746 0.439777093047989 0.0019569129986501 2 O94919 1 +DNA/RNA non-specific endonuclease superfamily [IPR044929] 0.8236267372600965 3.43093630642714 0.000601501814746 0.439777093047989 0.0019569129986501 2 O94919 1 +Alkaline-phosphatase-like, core domain superfamily [IPR017850] 0.8173395102581114 3.3999138725344857 0.0006740708182622 0.4776143006053908 0.0021557104537069 2 P15586 1 +RNA polymerase Rpb2, OB-fold [IPR014724] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.615404326605725 0.0029118559782677 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 superfamily [IPR037034] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.615404326605725 0.0029118559782677 2 Q9H9Y6 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033] 0.7958305757776325 3.2928468566528735 0.0009917847984131 0.615404326605725 0.0029118559782677 2 Q9H9Y6 1 +Beta-Galactosidase/glucuronidase domain superfamily [IPR036156] 0.7951687624090025 3.289529184931714 0.0010035514852502 0.6197420083095079 0.002935628269398 2 P08236 1 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.8693986487259592 3.2539441609165687 0.0011381464901185 0.6660150236089407 0.0031611691894179 3 O95831 1 +Ribosomal L18e/L15P superfamily [IPR036227] 0.8541041253762969 3.1832974307089303 0.0014560795782112 0.7541973956826663 0.0039058624897421 3 P46776 1 +Alpha/Beta hydrolase fold [IPR029058] 0.6983473058047746 3.17499202362006 0.0014984062007283 0.7640292273718446 0.0040082365869484 24 Q9H6V9,P48147,Q9NUJ1,Q9HB40,Q8NCC3,P07099,P42785,P10619,Q9H3G5 9 +Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068] 0.7610853739245562 3.116742066740888 0.0018286148632138 0.8283964035839673 0.0047210619658845 2 Q04760 1 +Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045] 0.7435473196558606 3.0263263097314548 0.0024754499679668 0.908077896210181 0.00617579875428 2 Q8TAG9 1 +PITH domain superfamily [IPR037047] 0.7379219060225055 2.9971032086629137 0.0027255841994215 0.9278004213201816 0.0065782896843182 2 Q9GZP4 1 +Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236] 0.7349437458636703 2.981588090126058 0.0028675753528539 0.937051731147282 0.0068199628270746 2 O00443 1 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.7266710787557968 2.9383294450910165 0.0032998616532973 0.9585398034151232 0.0076757651500611 2 O60637 1 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9739654185250196 0.0085479517159439 3 P10321 1 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9739654185250196 0.0085479517159439 3 P10321 1 +DNA polymerase family B, thumb domain [IPR042087] 0.7927838464084723 2.8935353010982277 0.0038093146799056 0.974660094142534 0.0085709580297876 3 P09884,P28340 2 +DNA polymerase, palm domain superfamily [IPR023211] 0.7927838464084723 2.8935353010982277 0.0038093146799056 0.974660094142534 0.0085709580297876 3 P09884,P28340 2 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.9292221481309424 2.8515218084297422 0.0043510501462358 0.9849924729796392 0.0095663499790527 5 Q9NZ08,P55786 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.9292221481309424 2.8515218084297422 0.0043510501462358 0.9849924729796392 0.0095663499790527 5 Q9NZ08,P55786 2 +Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241] 0.7041694242223742 2.8194525160082575 0.0048105647820619 0.9903784739891522 0.0104337249664993 2 Q96CW5 1 +Peptidase S8/S53 domain superfamily [IPR036852] 0.6975512905360737 2.7841465896849185 0.0053668772465642 0.9943844819534962 0.0115621986318599 2 P29144 1 +MIT domain superfamily [IPR036181] 0.6962276637988136 2.777066554846803 0.0054851945892977 0.994992320517459 0.0117080765728913 2 Q8N0X7 1 +Fibronectin type II domain superfamily [IPR036943] 0.7642275023646855 2.7549018201374724 0.0058709749884509 0.9965535503644029 0.0122111207643158 3 P11717 1 +Kringle-like fold [IPR013806] 0.7642275023646855 2.7549018201374724 0.0058709749884509 0.9965535503644029 0.0122111207643158 3 P11717 1 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.8254773991170337 2.698500649536798 0.0069652601990233 0.9988066782970818 0.0139740532742905 4 P42892 1 +EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044] 0.7437934458788442 2.6542096572851457 0.0079494417921619 0.9995407438301872 0.0155280171315455 3 Q6NUQ1,Q8TAG9 2 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.7252565375703345 2.561772285438608 0.0104139573881822 0.9999581419019145 0.0191386277954571 3 P35611,Q9UEY8 2 +LAP1C-like, C-terminal domain superfamily [IPR038599] 0.6386499007280013 2.4628916836539227 0.0137821544927323 0.9999984301394428 0.0242636467577719 2 Q8NFQ8 1 +Coatomer, gamma subunit, appendage domain superfamily [IPR037067] 0.6360026472534812 2.4481516361057416 0.0143591210234155 0.9999991064575806 0.0250890594771475 2 Q9Y678 1 +SNase-like, OB-fold superfamily [IPR035437] 0.7026461421976857 2.447596327531315 0.0143812677376795 0.9999991255845748 0.0250890594771475 3 Q9Y2W6 1 +NAP-like superfamily [IPR037231] 0.7695364238410527 2.4410298804028514 0.0146454429333313 0.9999993245303146 0.0254197007102873 4 Q9H0U9,P55209,Q99733 3 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.6964004885356148 2.415779608417495 0.0157015619261358 0.9999997595058596 0.0267848351484226 3 P61289 1 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.6964004885356148 2.415779608417495 0.0157015619261358 0.9999997595058596 0.0267848351484226 3 P61289 1 +Proteasome activator superfamily [IPR036252] 0.6964004885356148 2.415779608417495 0.0157015619261358 0.9999997595058596 0.0267848351484226 3 P61289 1 +Ribosomal protein L14 superfamily [IPR036853] 0.6201191264063606 2.3591599777182317 0.0183163577320415 0.9999999814387628 0.0305695883812062 2 P62829 1 +Porin domain superfamily [IPR023614] 0.7458752948130682 2.3297007696871472 0.0198219718436547 0.9999999957666964 0.0329113084231715 4 P45880 1 +Dynein heavy chain, C-terminal domain, barrel region [IPR043160] 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999983059186 0.0337029011987745 2 Q8NCM8 1 +Dynein heavy chain, domain 2, N-terminal [IPR042222] 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999983059186 0.0337029011987745 2 Q8NCM8 1 +Dynein heavy chain AAA lid domain superfamily [IPR042219] 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999983059186 0.0337029011987745 2 Q8NCM8 1 +Dynein heavy chain, AAA1 domain, small subdomain [IPR043157] 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999983059186 0.0337029011987745 2 Q8NCM8 1 +Dynein heavy chain, linker, subdomain 3 [IPR042228] 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999983059186 0.0337029011987745 2 Q8NCM8 1 +Rhodanese-like domain superfamily [IPR036873] 0.6022501654533499 2.257913032291844 0.0239510819604849 0.9999999999273668 0.037998174510621 2 P25325 1 +YjeF N-terminal domain superfamily [IPR036652] 0.5969556585043096 2.2276841670268994 0.0259015835638096 0.9999999999894188 0.0404266207000789 2 Q96F86 1 +Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502] 0.5943084050297894 2.2125304540543795 0.0269300343573541 0.999999999996174 0.0415319513232248 2 P09960 1 +CAP Gly-rich domain superfamily [IPR036859] 0.656405163853024 2.209172484071448 0.0271626459930898 0.9999999999969608 0.0415319513232248 3 Q99426,Q15813 2 +Mitochondrial carrier domain superfamily [IPR023395] 0.6120174277690443 2.1961651078722624 0.0280801278117615 0.999999999998775 0.0427190570027272 18 Q9Y6C9,O43772,Q9Y619,Q9H2D1,Q9UBX3,Q70HW3 6 +Ricin B-like lectins [IPR035992] 0.7137813641903336 2.1763777026119926 0.0295270296657355 0.9999999999997082 0.0447787867214225 4 Q10472 1 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.5268024177444678 2.135044209388201 0.0327573991166028 0.9999999999999882 0.0491360986749042 27 Q9BV44,O43159,P49327,P26358,Q8IY81,Q86X55,P52788,Q7Z2T5,Q08J23,Q8N6R0,Q7Z4G4,Q99873,Q9BV86 13 +DNA/RNA polymerase superfamily [IPR043502] 0.7032454625881226 2.1254668164855812 0.0335476801244436 0.9999999999999948 0.0500099318263765 4 P09884,P28340 2 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8010960970300951 2.0415535637676965 0.0411958355103989 1.0 0.0592113277559913 6 Q8WUJ1,Q9UMX5 2 +HAD-like superfamily [IPR036412] 0.6097282743611663 2.003856606146063 0.0450854230744766 1.0 0.0641318499567518 15 P05023,P34913,Q5TFE4,Q8NFW8,Q969T7,Q9HD20,Q9H857 7 +HAD superfamily [IPR023214] 0.6097282743611663 2.003856606146063 0.0450854230744766 1.0 0.0641318499567518 15 P05023,P34913,Q5TFE4,Q8NFW8,Q969T7,Q9HD20,Q9H857 7 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5710395091844257 2.001567199090979 0.0453312997171371 1.0 0.0643864920761106 19 O95831,P09622,Q6NUM9,P00390,Q9UHG3 5 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.5545996029119877 1.9821212234552177 0.04746567471045 1.0 0.0671210642381254 2 P52888 1 +Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261] 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.0684514484746646 3 Q9UHQ9,P00387 2 +Riboflavin synthase-like beta-barrel [IPR017938] 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.0684514484746646 3 Q9UHQ9,P00387 2 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.7608307393700363 1.9704879968101212 0.0487824693050087 1.0 0.0686805817846833 7 P31930,Q10713,Q5JRX3,P22695 4 +Bromo adjacent homology (BAH) domain superfamily [IPR043151] 0.6665424207766208 1.9459321959693696 0.0516628848887124 1.0 0.0722188065725873 4 P26358 1 +50S ribosomal protein L30e-like [IPR029064] 0.7711738114021168 1.9133695661902352 0.0557007576442132 1.0 0.0772125833369539 6 P55769,P62888 2 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.7083553493733556 1.8830565084531472 0.0596927103414182 1.0 0.0821201143696939 5 Q9HD20,P05023 2 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.7083553493733556 1.8830565084531472 0.0596927103414182 1.0 0.0821201143696939 5 Q9HD20,P05023 2 +P-type ATPase, A domain superfamily [IPR008250] 0.7083553493733556 1.8830565084531472 0.0596927103414182 1.0 0.0821201143696939 5 Q9HD20,P05023 2 +Myosin S1 fragment, N-terminal [IPR008989] 0.646790438524369 1.8479595387522043 0.0646081963280051 1.0 0.0880023947155148 4 P35580 1 +B30.2/SPRY domain superfamily [IPR043136] 0.7062966574763258 1.8301896367872823 0.0672215868916781 1.0 0.0913037915044936 8 Q1KMD3,P19474 2 +Immunoglobulin E-set [IPR014756] 0.5878119679548767 1.8246189321285984 0.0680585544392342 1.0 0.0923104055281444 14 P61916,A6NIH7,O43924 3 +Mss4-like superfamily [IPR011057] 0.5241561879550066 1.8016782434534195 0.0715960430283759 1.0 0.0966998449317336 2 Q7Z7K6 1 +RNA polymerase Rpb1, domain 3 superfamily [IPR042102] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.1131281121920772 3 O95602,O14802 2 +RNA polymerase Rpb1, funnel domain superfamily [IPR038120] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.1131281121920772 3 O95602,O14802 2 +RNA polymerase Rpb1, clamp domain superfamily [IPR044893] 0.5653757034094644 1.721038331331269 0.0852438684600334 1.0 0.1131281121920772 3 O95602,O14802 2 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.114487196835297 3 P20585,P52701 2 +MutS, connector domain superfamily [IPR036678] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.114487196835297 3 P20585,P52701 2 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.114487196835297 3 P20585,P52701 2 +RNA polymerase, RBP11-like subunit [IPR036603] 0.4996690933156957 1.6543620515802937 0.0980539720854791 1.0 0.1281220829285162 2 P19387 1 +DNA-directed RNA polymerase, insert domain superfamily [IPR036643] 0.4996690933156957 1.6543620515802937 0.0980539720854791 1.0 0.1281220829285162 2 P19387 1 +WWE domain superfamily [IPR037197] 0.5508109897385014 1.6408469620742754 0.1008291870072968 1.0 0.1315697928022043 3 Q7Z2W4,Q7Z6Z7 2 +Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940] 0.6476832738134719 1.599044910724546 0.1098106239389977 1.0 0.1417528563716553 5 P42356,O00443,P78527 3 +Aldehyde/histidinol dehydrogenase [IPR016161] 0.5758783843460288 1.530977528897323 0.1257749464124939 1.0 0.1602133245968673 11 P30837 1 +Aldehyde dehydrogenase, C-terminal [IPR016163] 0.5758783843460288 1.530977528897323 0.1257749464124939 1.0 0.1602133245968673 11 P30837 1 +Aldehyde dehydrogenase, N-terminal [IPR016162] 0.5758783843460288 1.530977528897323 0.1257749464124939 1.0 0.1602133245968673 11 P30837 1 +SWIB/MDM2 domain superfamily [IPR036885] 0.4728656518861795 1.4912206011838185 0.1359035866409723 1.0 0.1726585144264596 2 Q96GM5 1 +SUI1 domain superfamily [IPR036877] 0.4728656518861795 1.4912206011838185 0.1359035866409723 1.0 0.1726585144264596 2 O43583 1 +Ribosomal protein L13 superfamily [IPR036899] 0.4672402382528225 1.4567748190513798 0.1451785489704313 1.0 0.1832332144934802 2 P40429 1 +Protein-tyrosine phosphatase-like [IPR029021] 0.6460318785972053 1.4475065480010991 0.1477551038412834 1.0 0.1859976013060862 7 O14976,P10586,Q9Y217 3 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.4950164504023273 1.3896294718740712 0.1646414214961948 1.0 0.2045802437430137 17 P20618,P60900,P49720,P08243,P49721,P25788,P28074,P28072,Q06203 9 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.6182186545013822 1.3182488873119294 0.1874203450537814 1.0 0.2313920413933225 7 Q9BUF5,Q9BUK6,P68371,P07437 4 +GroES-like superfamily [IPR011032] 0.5542685398331391 1.2930004183244166 0.1960109144174548 1.0 0.2413791695447686 10 Q14914,Q8N4Q0 2 +Rab-GTPase-TBC domain superfamily [IPR035969] 0.575687313680038 1.2553325978609693 0.2093580462730511 1.0 0.2561776347661349 5 O60343,Q9Y3P9,Q9NVG8,Q66K14 4 +Concanavalin A-like lectin/glucanase domain superfamily [IPR013320] 0.4805893585221015 1.2522941406856811 0.2104627031447381 1.0 0.2572025166603843 16 Q1KMD3,P49257,P19474 3 +Chloramphenicol acetyltransferase-like domain superfamily [IPR023213] 0.5977935556803159 1.2230914136187938 0.2212951713294124 1.0 0.2699691838448968 7 P11182 1 +Nucleoside diphosphate kinase-like domain superfamily [IPR036850] 0.469380999668983 1.1858150865884876 0.2356953322736994 1.0 0.28658409719643 3 P22392,P15531 2 +Galactose-binding-like domain superfamily [IPR008979] 0.552453302547872 1.1804173008774552 0.2378342842635157 1.0 0.2888201964007132 9 Q9GZP4,P16278,O00462,P08236 4 +NAD(P)-binding domain superfamily [IPR036291] 0.3317991369894923 1.141935303442613 0.2534809128312294 1.0 0.3062761845125143 64 O43865,Q8N4Q0,Q13423,Q8NBX0,P35270,Q14914,Q8N8N7 7 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.3102625896986103 6 Q9BUF5,P68371,P07437 3 +Tubulin, C-terminal [IPR023123] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.3102625896986103 6 Q9BUF5,P68371,P07437 3 +Tubulin/FtsZ, C-terminal [IPR008280] 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.3102625896986103 6 Q9BUF5,P68371,P07437 3 +Bromodomain-like superfamily [IPR036427] 0.4595601926445614 1.1185918273755522 0.2633143116211394 1.0 0.3161741671959566 16 Q03164,P25440,Q9NPI1,Q9UIG0,Q86U86,Q9NRL2 6 +DUSP-like superfamily [IPR035927] 0.4547473567700399 1.103674247823479 0.2697344704833195 1.0 0.3234798195210918 3 Q86UV5 1 +PABC (PABP) domain [IPR036053] 0.4501820589208867 1.078094027801863 0.2809917965666924 1.0 0.3353099133751236 3 O95071,P11940 2 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.5288351424804683 1.061017906494366 0.288681763515868 1.0 0.3436347815399022 9 Q92804,O95218,P98175 3 +NTF2-like domain superfamily [IPR032710] 0.542156676841615 1.040846710738742 0.2979466971207998 1.0 0.3537887414640323 8 Q13555 1 +CH domain superfamily [IPR036872] 0.3889955655408196 1.018354525808241 0.3085095046696771 1.0 0.3649811461878366 26 Q15417,P21333,Q01082,Q96ED9,O15020,Q13576,Q5M775,O75369,Q14315,P46939,Q9UPN3,Q8WXH0,Q69YQ0 13 +Histone-fold [IPR009072] 0.5245716974268697 0.9562560704197948 0.3389428781738728 1.0 0.398537230380268 8 Q9NRF9,Q9NRG0 2 +PEBP-like superfamily [IPR036610] 0.3729318332230372 0.8781993198236787 0.3798355610741506 1.0 0.4422994501987993 2 Q96DV4 1 +AH/BAR domain superfamily [IPR027267] 0.4351502786759881 0.8759860404221691 0.3810376227228564 1.0 0.4431532975767434 13 Q9UQB8 1 +Metal-dependent hydrolase, composite domain superfamily [IPR011059] 0.4070302150896215 0.8389042288652772 0.4015230545508601 1.0 0.4653028899307802 3 P27708 1 +LSM domain superfamily [IPR010920] 0.4488743553498592 0.8287519389938786 0.4072447890013246 1.0 0.4708003983292624 11 P62316,P62310,Q9Y333,P62318 4 +Bcl-2-like superfamily [IPR036834] 0.3570483123759191 0.7832370761168574 0.4334879063633838 1.0 0.4975552489009995 2 Q9BXK5 1 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.4744949623090809 0.7753759416080708 0.4381175470260425 1.0 0.502270473554856 5 P27695 1 +Glutamine synthetase/guanido kinase, catalytic domain [IPR014746] 0.4671388676928296 0.7416321212370941 0.4583102563909427 1.0 0.5247952162954552 5 P12532 1 +Zinc finger C2H2 superfamily [IPR036236] 0.3759022102128347 0.6580254311151885 0.5105217899188315 1.0 0.579072418953869 18 Q9UGR2,Q8IWR0,Q15428,Q96ME7,Q92766,Q96KR1,Q9UKJ3 7 +Glycoside hydrolase superfamily [IPR017853] 0.3890334447315093 0.6547059566758953 0.5126570893656122 1.0 0.5808103259518642 15 P10253,P06280,O00462,P08236,P35573,P16278,O60502 7 +Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035] 0.3292521508934553 0.6222593027623046 0.5337713770397512 1.0 0.6020550233383501 2 P47897 1 +Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056] 0.3292521508934553 0.6222593027623046 0.5337713770397512 1.0 0.6020550233383501 2 P47897 1 +MFS transporter superfamily [IPR036259] 0.4766808084859791 0.6184428899537032 0.5362834328322292 1.0 0.6033188619362579 6 Q6NT16 1 +WD40-repeat-containing domain superfamily [IPR036322] 0.2710029987573569 0.6041779452183728 0.5457253423048745 1.0 0.6117968622114018 91 Q9BQ67,Q96DI7,P43034,P63244,P50748,Q6RFH5,O75083,P55735,O15143,Q9NNW5,O75530,Q5T4S7,O15213,O43818,Q92747,Q9UFC0,P62873,Q8WUA4,Q05048,Q9BZH6,Q9Y263,Q99570,Q9NV06,Q9H7D7,Q8NFH4,P61964,Q8NFH3,Q14137,Q8TEQ6 29 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.399622145197025 0.59902730632356 0.5491546755276935 1.0 0.6149255262013591 4 Q9Y2T2 1 +Immunoglobulin-like domain superfamily [IPR036179] 0.4036945315638287 0.5913968920809815 0.5542545222990802 1.0 0.6191961774640538 11 P10321,P10586 2 +PX domain superfamily [IPR036871] 0.4324054461961361 0.5904317852093648 0.5549012061827621 1.0 0.6192003030753185 9 O00443,Q9UNH7,Q13596,Q96L92,Q9UMY4,Q9Y5X1 6 +Zinc finger, CCHC-type superfamily [IPR036875] 0.4266815475155026 0.5621100180954333 0.5740410631612423 1.0 0.6376027033728677 5 Q9NUD5 1 +Pyridoxal phosphate-dependent transferase, small domain [IPR015422] 0.3743909464799107 0.5512166290136624 0.5814851820234517 1.0 0.644384614831512 14 P34896,P23378,O15269,P32929 4 +Ribosomal protein L2, domain 2 [IPR014722] 0.3950759412214361 0.5481853082389804 0.5835646690189262 1.0 0.6459457198450873 11 P50914,Q12888,O00267,P62917 4 +Pre-ATP-grasp domain superfamily [IPR016185] 0.4339652103556387 0.53964110510906 0.5894445632494865 1.0 0.6517050682081005 8 Q13085,Q96RQ3,O00763,P48637,P27708,P22102 6 +LDL receptor-like superfamily [IPR036055] 0.3093977498345547 0.5132140167485555 0.6078016221551465 1.0 0.6704615832020688 2 Q07954 1 +Pyridoxal phosphate-dependent transferase, major domain [IPR015421] 0.3583787834596546 0.482462829899891 0.6294771972272215 1.0 0.6904174725852099 15 P34896,P23378,O15269,P32929 4 +Pyridoxal phosphate-dependent transferase [IPR015424] 0.3583787834596546 0.482462829899891 0.6294771972272215 1.0 0.6904174725852099 15 P34896,P23378,O15269,P32929 4 +Phosphofructokinase superfamily [IPR035966] 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.7066742404243685 3 Q01813,P17858 2 +Zinc finger, RING/FYVE/PHD-type [IPR013083] 0.279451854608972 0.4453297455435112 0.656081474700438 1.0 0.7171469468064946 51 Q03164,Q9BZ95,O96028,Q7Z6E9,Q96T51,Q9UGU0,Q9Y4X5,Q9UIG0,Q8IWS0,P19474,P29083,Q9NRL2 12 +Death-like domain superfamily [IPR011029] 0.3283680900364045 0.4365450585643723 0.6624413148958468 1.0 0.7232777621822001 3 Q7Z434,Q96FV9 2 +Aldolase-type TIM barrel [IPR013785] 0.3390794809981364 0.3477001567604174 0.7280653789256835 1.0 0.7833820781066293 12 P06280,P43490 2 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.305254899523151 0.3350178522095213 0.7376116195112574 1.0 0.7918840463649286 3 O60884 1 +Protein kinase-like domain superfamily [IPR011009] 0.2592018262193598 0.328217041386195 0.7427475637554353 1.0 0.7965099152522096 63 O14976,Q96SB4,P11802,Q13308,P35790,O14965,P06493,Q00535,P42356,Q13555,Q96KB5,Q9HA64,P48729,Q05655,Q8TD19,P78527,P31751,O15111,Q99570,Q709F0,O00443,Q13557,P49840,O95747 24 +Papain-like cysteine peptidase superfamily [IPR038765] 0.3041622682217515 0.3147178102745231 0.7529759202883994 1.0 0.8030075428989243 21 O15484,Q13867,P53634,Q93009,Q9Y5K5,O94966,Q86UV5 7 +Rudiment single hybrid motif [IPR011054] 0.3830123116413956 0.2750306671151318 0.7832926775418789 1.0 0.8280031267539291 6 O00763,P22102,Q13085,Q96RQ3 4 +WD40/YVTN repeat-like-containing domain superfamily [IPR015943] 0.2437115003785371 0.2682023617731713 0.788543557142307 1.0 0.8319035982394251 100 Q9BQ67,Q96DI7,P43034,P63244,Q6RFH5,O75083,P55735,O15143,Q9NNW5,O75530,O15213,O43818,Q92747,Q9UFC0,P62873,Q8WUA4,Q05048,Q9BZH6,Q99523,Q9Y263,Q99570,Q9NV06,Q9H7D7,Q8NFH4,P61964,Q8NFH3,Q14137,Q8TEQ6 28 +Zinc finger, CCCH-type superfamily [IPR036855] 0.3454776660194381 0.2382307083395158 0.8117021608331605 1.0 0.8542832577949001 9 Q9UGR2,Q8IWR0 2 +Translation protein SH3-like domain superfamily [IPR008991] 0.3163522703127823 0.2074892584170515 0.83562778068846 1.0 0.8715383571094624 11 P50914,P62917 2 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.3285456528714006 0.2031636162395665 0.8390071497955429 1.0 0.8734744705439004 5 Q15369 1 +K Homology domain, type 1 superfamily [IPR036612] 0.2689545813942608 0.1785488152557996 0.8582919880074449 1.0 0.8910559102830194 26 Q9Y2W6,Q15365,Q96PU8,Q15366,Q92945 5 +Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091] 0.3194590309999291 0.1780665636689476 0.8586707006673333 1.0 0.8910559102830194 5 Q9P258 1 +PDZ superfamily [IPR036034] 0.2699066405527911 0.1442768400383671 0.8852818659230732 1.0 0.9117929806245127 21 Q53GG5 1 +Zinc finger, FYVE/PHD-type [IPR011011] 0.2591963186692786 0.1343728792013182 0.8931077263813714 1.0 0.917889797764419 27 Q03164,Q9BZ95,O96028,Q96T51,Q9UIG0,Q9NRL2 6 +Immunoglobulin-like fold [IPR013783] 0.258793895259394 0.1277954216047893 0.8983108733854839 1.0 0.9222530608424532 28 P21333,P04439,P10321,Q01968,Q8IZA0,P08236,Q96KP1,P10586 8 +BRCT domain superfamily [IPR036420] 0.2770190584123152 0.114167023980326 0.909105392004622 1.0 0.928386524390722 13 P09874,Q14676,O00541,Q12888,Q9NYB0 5 +GroEL-like equatorial domain superfamily [IPR027413] 0.2902648052362229 0.0865810986135116 0.9310044905935276 1.0 0.9437445520437548 9 P49368,P17987,Q99832 3 +TCP-1-like chaperonin intermediate domain superfamily [IPR027410] 0.2902648052362229 0.0865810986135116 0.9310044905935276 1.0 0.9437445520437548 9 P49368,P17987,Q99832 3 +GroEL-like apical domain superfamily [IPR027409] 0.2902648052362229 0.0865810986135116 0.9310044905935276 1.0 0.9437445520437548 9 P49368,P17987,Q99832 3 +ANL, N-terminal domain [IPR042099] 0.3005301524188141 0.0778189596252227 0.9379720645827244 1.0 0.948741677589322 6 O95573,Q9P265,P33121,O60488,Q4G176 5 +ClpP/crotonase-like domain superfamily [IPR029045] 0.2607903976247712 0.07003814619768 0.9441632978948896 1.0 0.9530704988184262 12 O00763,P40939,Q13085,P42126 4 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.2159575476651094 0.0329086266416406 0.9737474534580242 1.0 0.9819045001885626 86 Q9UGR2,P31948,Q99747,Q6DKK2,Q6PGP7,Q9Y5A7,Q5R3I4,Q96BR5,O00170,O43765,Q99615,O75718,O75153,Q9UBV2,Q9UPR3,Q8IWR0,P50542,P30260,Q14CX7,P49792,A0AVF1 21 +Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047] 0.2595293337752624 0.0257468397654105 0.979459263494992 1.0 0.9866310363448506 7 Q15269,Q8N766,Q9HCU5,Q9HC35,Q8IWA0,Q8TEQ6 6 +Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001] 0.2345924453280281 0.0059431725525944 0.995258062293348 1.0 1.0 6 Q05639,P41091,O00178,Q9Y450,P15170 5 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a4ed4f055599536ae3a22bf3633a4e0e55f3c67b --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "AN1-like Zinc finger [IPR035896]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP synthase-coupling factor 6 superfamily, mitochondrial [IPR036204]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adaptor protein Cbl, N-terminal domain superfamily [IPR036537]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Alba-like domain superfamily [IPR036882]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CGI121/TPRKB superfamily [IPR036504]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily [IPR023471]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit VIb superfamily [IPR036549]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "DhaL domain superfamily [IPR036117]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GBBH-like, N-terminal domain superfamily [IPR038492]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glu-tRNAGln amidotransferase superfamily, subunit C [IPR036113]", "Glutamine synthetase, N-terminal domain superfamily [IPR036651]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Helix hairpin bin domain superfamily [IPR029012]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTERF superfamily, mitochondrial/chloroplastic [IPR038538]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Mediator complex subunit 25, PTOV domain superfamily [IPR038196]", "Mediator complex, subunit Med7/Med21-like [IPR037212]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily [IPR036522]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nuclear hormone receptor-like domain superfamily [IPR035500]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Plus3-like superfamily [IPR036128]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Pre-mRNA-splicing factor Isy1 superfamily [IPR037200]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily [IPR038085]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RUN domain superfamily [IPR037213]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S14/S29 [IPR043140]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21 superfamily [IPR038380]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S6 superfamily [IPR035980]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rubisco LSMT, substrate-binding domain superfamily [IPR036464]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SATB, CUTL domain superfamily [IPR038216]", "SATB, ULD domain superfamily [IPR038224]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKA1 microtubule binding domain [IPR042031]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily [IPR036739]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Signal recognition particle, subunit SRP19-like superfamily [IPR036521]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TAP42/TAP46-like superfamily [IPR038511]", "TBCC, N-terminal domain superfamily [IPR038397]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Taurine dioxygenase TauD-like superfamily [IPR042098]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Toll/interleukin-1 receptor homology (TIR) domain superfamily [IPR035897]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Villin headpiece domain superfamily [IPR036886]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps53, C-terminal domain superfamily [IPR038260]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "XRCC4, N-terminal domain superfamily [IPR009089]", "XRCC4-like, N-terminal domain superfamily [IPR038051]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "tRNAHis guanylyltransferase Thg1 superfamily [IPR038469]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5J", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATRX", "ATXN10", "AURKA", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCKDHA", "BCL2L13", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACUL1", "CACYBP", "CAD", "CADM1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CELF1", "CENPV", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHTF18", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "COA7", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTD", "DCTN1", "DCUN1D5", "DCXR", "DDB1", "DDHD2", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DHCR24", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERI1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAM129B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FIS1", "FKBP10", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GOLPH3", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD2", "GPHN", "GPI", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPDH2", "INF2", "INTS1", "INTS11", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITSN2", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LZIC", "MACF1", "MAGED2", "MAGT1", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED21", "MED25", "METAP1", "METAP2", "METTL13", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL4", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS25", "MRPS27", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCBP1", "NCBP3", "NCDN", "NCKIPSD", "NCL", "NCOA5", "NCOR1", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NENF", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PCYOX1L", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PUS1", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPUSD3", "RREB1", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SAAL1", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCAF8", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMS", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX12", "STX3", "STX4", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFRC", "THADA", "THEM6", "THG1L", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMA16", "TMED2", "TMED7", "TMEM115", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52L2", "TPI1", "TPM4", "TPMT", "TPP1", "TPP2", "TPRKB", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC27", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UACA", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXS1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WRAP53", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMYM1", "ZMYND8", "ZNF280C", "ZNF281", "ZNF512", "ZNF638", "ZPR1", "ZRANB2", "ZYG11B"], "leading_proteins": ["ABHD10", "ACACA", "ACACB", "ACAD11", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ADD1", "ADD3", "AGL", "AHCYL1", "AIFM1", "AIP", "AKT2", "ALDH1B1", "AP3M1", "APEX1", "APP", "ARIH1", "ARPC1A", "ARPC1B", "ASNS", "ATP13A1", "ATP1A1", "AURKA", "BAIAP2", "BAZ1A", "BAZ1B", "BCL2L13", "BLMH", "BOP1", "BRD2", "BRD7", "CAD", "CAMK2D", "CAMK2G", "CAPN5", "CARM1", "CCT3", "CCT7", "CDC27", "CDK1", "CDK4", "CDK5", "CENPV", "CHKA", "CHRAC1", "CHUK", "CKMT1A*", "CLUH", "CMAS", "CNN3", "COA7", "COPG1", "CPVL", "CRTAP", "CSNK1A1", "CSTF1", "CTH", "CTSA", "CTSC", "CYB5D2", "CYB5R1", "CYB5R3", "DBT", "DCAF13", "DENR", "DHCR24", "DIP2B", "DLD", "DNAJA2", "DNAJC7", "DNMT1", "DYNC2H1", "ECE1", "ECI1", "EDC3", "EED", "EEF1A2", "EIF2S3", "ELOC", "EMC1", "EML4", "ENDOD1", "EPHX1", "EPHX2", "ERAP1", "EXOC2", "EXOC6", "FASN", "FLNA", "FLNB", "FLNC", "FN3KRP", "FTSJ3", "GAA", "GAK", "GALNT1", "GART", "GEMIN5", "GLA", "GLB1", "GLDC", "GLO1", "GNB1", "GNS", "GPATCH8", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GTF2E1", "GTF3C2", "GTPBP1", "GUSB", "HADHA", "HBS1L", "HLA-A", "HLA-C", "HMOX2", "HNRNPUL2", "HOOK2", "HUWE1", "IGF2R", "IQGAP2", "KHSRP", "KIAA0319L", "KMT2A", "KNTC1", "LDAH", "LMAN1", "LRP1", "LRWD1", "LSM2", "LSM3", "LTA4H", "MACF1", "MANBA", "MAVS", "MCAT", "MCCC1", "MDC1", "METTL13", "MGEA5", "MPST", "MRPL38", "MRPL4", "MSH3", "MSH6", "MSTO1", "MTCH2", "MTMR6", "MYH10", "NAA25", "NAMPT", "NAP1L1", "NAP1L4", "NAPG", "NEK9", "NENF", "NME1", "NME2", "NNT", "NPC2", "NPEPPS", "NSD2", "NSD3", "NSUN2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUP37", "NUP43", "OCRL", "OXSR1", "PABPC1", "PAFAH1B1", "PARP1", "PBK", "PBRM1", "PCBP1", "PCBP2", "PCYOX1", "PDE6D", "PDLIM3", "PES1", "PEX5", "PFKL", "PFKP", "PHF6", "PI4KA", "PIK3C2A", "PIK3R4", "PITHD1", "PITRM1", "PLA2G15", "PLAA", "PMPCA", "POLA1", "POLD1", "POLE3", "POLR1A", "POLR1B", "POLR2C", "POLR3A", "PPAT", "PRCP", "PREB", "PREP", "PRKCD", "PRKDC", "PRMT1", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB5", "PSMB6", "PSME3", "PTGR1", "PTGR2", "PTK7", "PTPRF", "PWP2", "QARS", "QKI", "RABGAP1", "RACK1", "RANBP2", "RBBP6", "RBM10", "RCC2", "RETSAT", "RINT1", "RPL13A", "RPL14", "RPL23", "RPL27A", "RPL30", "RPL8", "RREB1", "RRP8", "RRP9", "RUFY1", "SCCPDH", "SCPEP1", "SEC13", "SEL1L", "SF3A2", "SGTA", "SHMT1", "SLC18B1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SMARCD1", "SMG5", "SMS", "SNRNP40", "SNRPD2", "SNRPD3", "SNU13", "SNX1", "SNX12", "SNX27", "SNX6", "SNX9", "SORT1", "SPART", "SPECC1", "SPECC1L", "SPR", "SPTBN1", "SPTBN2", "SPTLC1", "SRPK1", "STIP1", "SUPT5H", "SYNE2", "TAF15", "TBC1D13", "TBC1D4", "TBC1D9B", "TBCB", "TBCE", "TCF20", "TCP1", "TDRKH", "TERF2IP", "THOC1", "THOP1", "THUMPD3", "TIMM13", "TIMM8B", "TOR1AIP2", "TP53BP1", "TPP2", "TRIM21", "TRMT11", "TRMT1L", "TSPAN3", "TSPYL1", "TTC19", "TTC26", "TTC37", "TTC38", "TUBB", "TUBB4B", "TUBB6", "TUBGCP3", "UBR4", "UBR5", "UCHL5", "UNC119B", "UQCRC1", "UQCRC2", "USP19", "USP48", "USP7", "UTRN", "VDAC2", "WDR1", "WDR11", "WDR26", "WDR46", "WDR5", "WDR6", "WDR74", "WDR75", "ZADH2", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZCCHC3", "ZFR", "ZNF512", "ZRANB2"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ca15805d9e276f930fdadf70fe0a7a4038c64019 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e8e977f5d04a57b75b5902141ddb3555806f2d3eec71a645a6c97cdf34c722d7 +size 67486 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2de6c625484b5a62771cd4d2bb3f0d7fe6691af0 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..105c1bedea6b57493c61bc0cd48b3fc8827f0874 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..41e52f5306b48b88c81e717a693c97e4fae7567f --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.7083553493733556 1.8830565084531472 0.0596927103414182 0.2182296197819206 0.0795902804552242 5 Q9HD20,P05023 2 +EGF-type aspartate/asparagine hydroxylation site [IPR000152] 0.3315684976836604 0.6353485771304267 0.5252010981201116 0.9491795128945508 0.5252010981201116 2 Q07954 1 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..90d8585cbfb91865f009c84bb7c23664d02b22cc --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "EIF5A", "FASN", "LRP1", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP1A1", "LRP1"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e41a96bf690db2feea3bef4afd31d62f886fe616 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:49c2d738247359a0aa7daf9eb683bc004c52f8ef3da641c6d68d6c632065aaac +size 193509 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..8b79ca6618235caaafddf9096d9bd1e8b7fd2100 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]", "1": "Spectrin repeat [IPR002017]", "2": "WD40 repeat [IPR001680]", "3": "Tetratricopeptide repeat [IPR019734]", "4": "Spectrin/alpha-actinin [IPR018159]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..590709c79c56ccd8e3e9ff54496b5a28fdfad7e4 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0bae7d7e0282d3320ca8aa5d6d35210553e5b22645dc633a71a952f73637a0cb +size 143128 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..1c50813ea3303f55ce755549f4c58a10316ec71f --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e850bb57ba838e1022008585bc1e6b0bde917189bc88dedb776e8ab406b75e24 +size 135592 diff --git a/interpro_repeat/basic/plot_2.png b/interpro_repeat/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..1c2ef357597db33ba8542068b91d3f63c3681b2e --- /dev/null +++ b/interpro_repeat/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:20f2095fa472a51c7306be42550a186dfbe4b2e71c1246d1b3047d0c8a12be8c +size 150075 diff --git a/interpro_repeat/basic/plot_3.png b/interpro_repeat/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..6079d08da8137664bfbba0d0e0c49f1c1246e26c --- /dev/null +++ b/interpro_repeat/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:83edf9c4eb5e3cb2df1119352b88cb42998d4bc8a5adfe537fc9aa3e549888ea +size 153485 diff --git a/interpro_repeat/basic/plot_4.png b/interpro_repeat/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..955e8c16d8fa7a3e9f54ca9d6abeeedc03559db2 --- /dev/null +++ b/interpro_repeat/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4a36ab667ad9226b5cdf12d0b9d45f52f34b5c2e43cbe6b9987d607194786904 +size 144246 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0ae70ba7a1f92e2c2f1ec4e8824023835ec85d85 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9bbaa9cf0734e1308344df795f83c5b9e8fe932664077e788cdd42da241cdb8f +size 84851 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9246a9a089a6a9f7c524311dc2d950b7f193b3bb --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 6 18 2.1961651078722624 0.0280801278117615 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0148056693212618 0.0513963234576887 0.002019433305579 0.0020709532532559 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e08dca76d2f18c8cac8c5cc7af56aebbef9e2d3f --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 74, + "title": "Average number of proteins per term", + "value": 5.621621621621622 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..edd9121d4c6e33eaba5bde2a06e59a310c9e4bef --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bb8ad9e3dba03a28672121f400b2751306ae9029 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,15 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sel1-like repeat [IPR006597] 0.7769688947716769 3.1977384011552923 0.0013850986845915 0.0974835418052033 0.0044564044634685 2 Q9UBV2 1 +Leucine rich repeat 4 [IPR025875] 0.8011343152756267 2.933623354498735 0.0033503049459953 0.2199044010452065 0.008264085533455 3 Q9UFC0 1 +Mitochondrial substrate/solute carrier [IPR018108] 0.6120174277690443 2.1961651078722624 0.0280801278117615 0.8784782028116491 0.0494745109064369 18 Q9Y6C9,O43772,Q9Y619,Q9H2D1,Q9UBX3,Q70HW3 6 +Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547] 0.4877564526803551 1.5820732328791585 0.1136328533700288 0.999867135139756 0.1751839822787944 2 Q00610 1 +Proteasome/cyclosome repeat [IPR002015] 0.4268696227663893 1.208332175293958 0.2269195169974365 0.9999999946466148 0.3109637825520426 2 Q13200 1 +Spectrin repeat [IPR002017] 0.5450155200490435 1.142768435589953 0.2531347473157441 0.9999999995832008 0.3344994875243762 9 Q01082,O15020,P46939,Q13813,Q9UPN3,Q8WXH0 6 +Tetratricopeptide repeat 2 [IPR013105] 0.4467801177861023 0.8281016760898936 0.4076129203877889 1.0 0.5112433238762099 4 P31948 1 +WD40 repeat [IPR001680] 0.2700320054100905 0.6151443687547614 0.5384593829880011 1.0 0.6517358152435418 87 Q9BQ67,Q96DI7,P43034,P63244,Q6RFH5,O75083,P55735,O15143,Q9NNW5,O75530,O15213,O43818,Q92747,Q9UFC0,P62873,Q8WUA4,Q05048,Q9BZH6,Q9Y263,Q99570,Q9NV06,Q9H7D7,Q8NFH4,P61964,Q8NFH3,Q14137,Q8TEQ6 27 +Tetratricopeptide repeat [IPR019734] 0.3053736019051977 0.5777017366683505 0.5634655064664087 1.0 0.6517358152435418 45 Q9UGR2,O00170,O43765,P30260,P31948,P50542,P49792,A0AVF1,Q99615,Q6DKK2,Q6PGP7 11 +Spectrin/alpha-actinin [IPR018159] 0.3929956777957463 0.5378833041346602 0.5906576155926961 1.0 0.6723737941413511 11 Q01082,O15020,P46939,Q13813,Q9UPN3,Q8WXH0 6 +Low-density lipoprotein (LDL) receptor class A repeat [IPR002172] 0.3093977498345547 0.5132140167485555 0.6078016221551465 1.0 0.6723737941413511 2 Q07954 1 +Regulator of chromosome condensation, RCC1 [IPR000408] 0.3642140475376421 0.4404241865773893 0.6596299104865742 1.0 0.7178325496471542 4 Q9P258 1 +Hexapeptide repeat [IPR001451] 0.2734193975504712 0.2147432611143383 0.829967491820351 1.0 0.8773942056386568 3 Q96IJ6,Q13144 2 +Tetratricopeptide repeat 1 [IPR001440] 0.2801855190232119 0.0792772259826124 0.9368121203118902 1.0 0.9368121203118902 10 P30260 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..82abee72fbbdc6898f2dfe958eea1e3ef32ca3dd --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Fis1, C-terminal tetratricopeptide repeat [IPR028061]", "Fis1, N-terminal tetratricopeptide repeat [IPR028058]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANKFY1", "ANKHD1", "ANKRD17", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", 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0.0008837089638654 0.0005129796299666 0.0062789268380777 +Protein localization to mitochondrion 17 57 3.507849162451547 0.0004517451068899 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 1.3368153393846353e-05 8.722958438443945e-06 2.766832156184514e-07 1.970070511196497e-07 +Steroid biosynthetic process 9 42 3.505504384836005 0.0004557429943266 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 0.0118439766153403 0.0023748989920053 0.0022734528645619 0.0190063352955717 +Organic hydroxy compound metabolic process 21 107 3.453388528603375 0.0005535910452203 24.233009708737864 110.8883495145631 0.5334558429683288 0.4627633417898757 8.017219191403747 10.01417249072314 1.2419084217888356 0.3713800795527268 0.0128569324367351 9.23670224417545e-05 0.0001905055623138 0.0065714077224903 +Protein targeting to mitochondrion 16 46 3.4389487079368006 0.0005839778680432 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 4.077523840808141e-06 1.8642648229886668e-06 1.569882637987987e-07 1.68741532610928e-07 +Steroid metabolic process 14 65 3.422474999020287 0.0006205380419255 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 0.0009563326986827 2.325961422096677e-06 9.56924650095516e-05 0.0037129738591824 +Regulation of blood pressure 7 16 3.339668935900417 0.0008387831727325 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0028326312129738 1.827159812714955e-05 6.729015359856693e-05 0.0065824357934952 +Regulation of system process 10 56 3.290723795361522 0.0009992997870398 12.432038834951456 59.63106796116505 0.142870153937744 0.6256858745623561 5.047131523930307 6.726256754497268 0.8769607822191469 0.3283787852153951 0.0201607288738593 0.0009992635490144 0.0138045421546396 0.3397029576237255 +Fatty acid metabolic process 19 91 3.200403544411948 0.0013723529467881 20.638349514563107 97.41504854368932 -0.9807147090793946 0.3485945363485703 9.914086535783548 9.494253077651653 1.344376564211378 0.3344958336050588 0.0007626658908413 0.0211565741329276 0.0001032494475424 0.0005824509237127 +Organic hydroxy compound biosynthetic process 10 47 3.1724427700296265 0.0015116234921985 12.42233009708738 52.37135922330097 0.7934054609743442 0.424605725297311 4.713262264354627 5.1877801804871915 1.1130427360157376 0.3580104692277669 0.1349531687426338 0.0084980050977086 0.0042838436358731 0.0535037525464888 +Circulatory system process 11 65 3.100601399392252 0.0019312807612041 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.0304145205249448 0.0022466657765122 0.0139346649064091 0.287315189315804 +Sterol metabolic process 12 38 2.9864206409712297 0.0028226408901239 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 0.0082661149627475 1.429145151632323e-06 5.474991993251875e-06 0.0002122388464955 +Ion transport 31 184 2.913657469922772 0.0035722162348392 59.95631067961165 203.33495145631068 1.28794420214731 0.4483240343684334 22.7179419701651 20.293344878478432 1.852388371824549 0.4292871393353351 0.0111844706436696 0.0073648817034719 0.0051146660268219 0.1005807548967817 +Sterol biosynthetic process 6 23 2.91204563087059 0.0035907017683682 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 0.2067156970649581 0.0102837000876808 0.0008515908739311 0.0070893533545687 +Glycerolipid biosynthetic process 13 39 2.910240889325721 0.0036115028459762 13.466019417475728 44.71844660194175 0.9430872689732808 0.3767257192898063 6.88753698417372 8.249645447783736 1.3199493331746477 0.3584243730449019 0.0587615611733179 0.2522992371519743 0.6366705766629369 0.1019407455056014 +Response to nitrogen compound 34 224 2.872427090711706 0.0040733205802094 45.4247572815534 232.75 0.042710442463939 0.8941347715182684 14.069752334932211 21.513669734308305 0.3781317508190892 0.2101268567750735 0.411937063642349 0.0532983538108643 0.0005974761436492 0.0210782557856236 +Anatomical structure maturation 9 28 2.859507453627067 0.0042429944704747 6.815533980582524 30.893203883495147 0.3841260505655395 0.5416451005267833 3.09006416754166 4.620895179443306 0.9281404590939007 0.3269797675509184 0.4308176920885813 0.0239832744272861 0.1395558016319039 0.0500599336441153 +Pigment metabolic process 5 27 2.79995685344519 0.0051109437510481 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0024333620388206 0.0001760490995981 0.0019598595015423 0.0164244734054917 +Cell projection organization 54 235 2.78551512491732 0.0053442746679883 54.529126213592235 250.1771844660194 0.0885716979556682 0.8002003294890062 21.77302656141916 31.312086500340524 0.7390344422983982 0.3036099690788064 0.2114347568686337 0.1569714817485031 0.6107838197811704 0.6036725117148368 +Anion transport 15 58 2.783481765130769 0.0053778885382369 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 0.0163819448392597 0.0433836663756183 0.0010683786125278 0.0175185916339299 +Response to bacterium 9 56 2.773396583669667 0.0055474469441949 11.235436893203884 58.29126213592233 0.1154865730357222 0.623946124032815 4.342207231820677 6.938189053279808 0.7858164052781929 0.3116148730227279 0.0043835120706257 0.019558511935876 0.0406954920694641 0.1869981081198725 +Protein transmembrane transport 7 25 2.753577473374786 0.0058947816567083 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0001255471891058 0.0016384890204764 0.0016151716069533 0.00375910232126 +Macromolecule depalmitoylation 2 5 2.745692796216572 0.0060383276520195 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0573151884822011 0.1094892401774078 0.0025675639060761 0.018020673376298 +Regulation of response to external stimulus 24 120 2.720426711802307 0.0065197722433374 27.32766990291262 129.63349514563106 0.3937649860570471 0.6986677015868525 9.316542933972368 15.399506498758855 0.8616366228871625 0.3591499966721317 0.3574226207331185 0.0563623421842366 0.0319301124793178 0.1530403115956425 +Modification of postsynaptic actin cytoskeleton 3 5 2.7202115132165368 0.0065240170737936 1.2718446601941749 4.691747572815534 0.7749873285721138 0.3698922532933065 1.1736936531325053 0.5210425083463128 1.0158209432526408 0.3028676273114866 0.000647621121882 0.002465796513642 0.0007018811705627 0.0003286021100258 +Alcohol biosynthetic process 8 33 2.7100703356929645 0.0067268941437959 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 0.3523884632837075 0.0526082110144703 0.005164023891344 0.0265567637490863 +Purine nucleotide salvage 1 5 2.6706012823497987 0.0075715525357651 2.0679611650485437 5.128640776699029 0.2558101865939456 0.4027366561517723 1.6503140973314958 0.7730001426087728 1.1650486447499997 0.2988088626042584 0.0432957136582515 0.0832836732680532 0.018519525655472 0.0675218785318175 +Purine ribonucleotide salvage 1 5 2.6706012823497987 0.0075715525357651 2.0533980582524274 4.936893203883495 0.2808165383528844 0.3980862538317732 1.6031107826209183 0.6725535011399171 1.16348345355908 0.2954242001144523 0.0338360956076009 0.0653907127050202 0.0111508905617615 0.0419919493306108 +Amp salvage 1 5 2.6706012823497987 0.0075715525357651 1.91747572815534 4.635922330097087 0.265573089223418 0.4091186067198797 1.492045392504656 0.515272454828754 1.1444474328484808 0.294450018392828 0.0242848323540905 0.0471521402185075 0.0054816148577098 0.0213301790272909 +Nucleotide salvage 1 5 2.6706012823497987 0.0075715525357651 2.2815533980582523 5.953883495145631 0.203366659475343 0.4039201470736932 1.813741911870816 0.8759513363812925 1.1722588299831294 0.2998717312129536 0.0711332726649859 0.1349531130589082 0.0491545726752397 0.1630814235328921 +Fatty acid beta oxidation using acyl coa oxidase 2 5 2.653441460333461 0.0079675589583214 1.7815533980582523 5.230582524271845 0.1174066793558913 0.4945876710836515 1.225081536641742 1.2819647581926723 0.9533870490929204 0.2768085841542957 1.0 1.0 0.0014512760162947 0.0105668672564949 +Phosphatidylcholine metabolic process 4 11 2.638855152027717 0.0083186515582622 3.75 12.592233009708735 0.9144963280277142 0.2812959412325629 1.879404212556404 2.4412987678409657 1.1545250012369797 0.2602001877022786 0.0155575631698287 0.0538434207197609 0.0665120453316815 0.0390278099301106 +Positive regulation of ion transport 6 34 2.63493533605592 0.0084153313285981 9.75242718446602 39.09708737864078 0.1948252561601866 0.6796495505979099 4.075961847535128 4.674376679502791 0.7078649089176284 0.3044976342479915 0.1043267655807623 0.0929934383816013 0.1323237158537072 0.3013722093479412 +Ph reduction 5 11 2.6306214852220617 0.0085228902083172 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.1287528218161406 0.0293903981750984 0.0288428745821564 0.001918269568256 +Establishment of protein localization to organelle 38 179 2.627129268189887 0.0086108615276048 40.4247572815534 180.123786407767 0.6176411706537287 0.628535284461401 14.116769229706104 14.40373863390995 1.0281809729691214 0.3983757503188239 0.0003094251746602 0.0006084334325829 4.786589982396597e-05 1.5617996853546942e-06 +Cellular hormone metabolic process 4 18 2.621359752312136 0.0087579788882241 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0257915242502586 0.0128487417044244 0.0336895534920958 0.1000707214680032 +Cellular response to biotic stimulus 6 34 2.611292009460805 0.0090200837318614 8.070388349514563 35.616504854368934 0.7964477296470692 0.4798420500319036 3.1871094803090645 3.824235365857021 0.8467616012566905 0.3489796792314515 0.0022248923692317 0.0045866083337414 0.0190345100678685 0.097972574862474 +Regulation of ion transport 13 68 2.602840144043605 0.009245505143725 17.640776699029125 78.38349514563107 0.268861732893133 0.649064160670491 6.342726694491137 8.788149535025928 0.7853614201571752 0.3276987608120678 0.0371879146714664 0.0120091141738882 0.0930422567205385 0.3728578209620084 +Organic acid metabolic process 32 283 2.6027826356464714 0.009247056029223 71.54368932038835 291.15291262135923 -0.853586375997507 0.4933041409778534 26.29639744200239 21.3733210039979 1.135284987742292 0.353756439736918 0.0005503808319473 0.0005580784600925 4.172200523867661e-05 0.0061711127250366 +Hormone metabolic process 5 28 2.597262435061974 0.0093970097690108 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0817843887077026 0.0140771202758893 0.0839989284318907 0.331558008102774 +Regulation of systemic arterial blood pressure 3 8 2.596112462780229 0.0094285199036396 1.9514563106796117 7.480582524271845 0.6591644372092078 0.3227631999327531 1.1543807719023411 1.5318976272183211 1.1594175747176596 0.2663405748898474 0.0087935329278829 0.0001585002786519 0.0048164404979701 0.0498364179528963 +Lipoprotein metabolic process 2 17 2.5916272277228383 0.0095523213749257 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.0650462755169659 0.1967082241040804 0.334963823998796 0.788306927166903 +Detection of biotic stimulus 1 5 2.582494820870061 0.0098088834433589 1.4199029126213591 4.512135922330097 1.0591375818870654 0.2422781473049772 1.0196572764649048 1.0250968701423322 1.0664360760371396 0.2315508201016763 0.0015075035399645 0.0056684159955205 0.0323840811666381 0.018020673376298 +Cellular response to endogenous stimulus 32 209 2.580981525681344 0.0098519853824505 46.65533980582524 226.83252427184465 -0.160788978904248 0.7763175668763687 18.10976901074103 25.484501485376335 0.5628314501246097 0.2836421375177856 0.512332044353879 0.0282168728065174 0.0241132792529176 0.3023671133525966 +Organophosphate catabolic process 6 33 2.574282464611424 0.0100448230061618 6.774271844660194 36.1626213592233 -0.2921408084661334 0.4220223947837425 3.717580668013521 4.268336903829444 1.180846654986601 0.3079166774800768 0.0018220351396772 0.0036338339198907 0.0144872792095396 0.0347305706128729 +Body fluid secretion 3 14 2.5606452467114584 0.0104477980349269 3.611650485436894 13.691747572815531 0.5614164790218804 0.4834047231691153 2.085469888187935 1.6735027663843434 0.894552067234308 0.3061879015966331 0.1988423464133734 0.3530974878629287 0.6660978714719568 0.1732034237667374 +Icosanoid metabolic process 7 16 2.5439138925929825 0.0109618103334669 4.75 19.37378640776699 -0.8399180664351888 0.2450035647659444 2.0056050100432734 1.995405458715 1.3397112170072694 0.2370184574682143 5.485404065986301e-05 0.0007430351028178 6.946142717498723e-06 0.0009402069411773 +Negative regulation of response to external stimulus 7 43 2.543813811631233 0.0109649514127969 9.381067961165048 47.019417475728154 0.8063071074275461 0.4700507256615295 4.127569023520378 6.3589713134688575 0.9364755672970396 0.3491987458588393 0.0511928730161325 0.0243497840139476 0.0540771460595213 0.1276516327537887 +Peptide catabolic process 3 9 2.543138199462992 0.0109861766912615 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0892490045576324 0.0007461625149634 0.0009487109772629 0.0118865434534573 +Regulation of lipid localization 5 24 2.540192077987088 0.0110791604288891 4.978155339805825 22.567961165048544 0.1717129002526148 0.4994483702351445 2.509594887654458 3.4172240364068465 0.9420644920260158 0.2891754608342733 0.0005589245270722 0.0008977570976206 0.0110083802883316 0.0348939723114254 +Regulation of defense response 18 84 2.5369627164299167 0.0111818862130836 20.351941747572816 89.95145631067962 0.3090454403231809 0.6824878992411626 7.399483130499616 11.222488380567595 0.777906173710776 0.3278161680699026 0.7715962839492455 0.0653061147287855 0.0264568564843704 0.0842062083049828 +Phospholipid metabolic process 20 66 2.5342936315992923 0.0112674272370321 18.805825242718445 74.80339805825243 -0.0109191555178773 0.4658808189502442 8.677118948764809 11.032066592781655 1.2956045948013235 0.3559409313369701 0.1279642298926664 0.4430254877041329 0.5750756838965716 0.0404192257565703 +Response to endogenous stimulus 38 261 2.524297870411776 0.0115929651789254 52.060679611650485 278.3033980582524 -0.0574210767621067 0.8142217503475416 19.652903328690797 29.262333522986196 0.5425193479116073 0.2778283155224302 0.2669766203359555 0.0219105451683795 0.0131485134346399 0.2850793186081545 +Regulation of autophagy 20 84 2.52373936067029 0.0116113982389329 20.118932038834952 94.3495145631068 0.711099590941891 0.531831837860264 6.9602150135047 11.998348379757145 0.9791686068293384 0.3767967479294735 0.1482089148241369 0.0156735185747296 0.0313031165024697 0.0130207897948086 +Positive regulation of actin filament polymerization 3 11 2.5211146563243347 0.0116983727168762 2.8810679611650487 11.968446601941748 0.4050811393531375 0.509845801610572 2.2572280503106983 1.7657679411253135 0.9313651581582132 0.3163299212061122 0.0133509861907553 0.004885623522166 0.0547180422889405 0.0952062556054938 +Protein transmembrane import into intracellular organelle 3 13 2.5139467533552224 0.0119388457771323 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0004104233816526 0.0028960612595367 0.0054543168641633 0.0137665493817408 +Sterol transport 5 25 2.511292759699141 0.0120289892019389 5.516990291262136 23.23058252427185 0.3564989162781894 0.4550431454343515 2.7566693478017315 3.339632072416373 1.1016145306573315 0.3225081354886266 0.0044455523824174 0.0004780854780595 0.0057156172518009 0.0460574281433519 +Ion transmembrane transport 24 138 2.506939408731936 0.0121781585510662 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 0.3898606466843485 0.0724032025482793 0.0069979062203467 0.0367789547340115 +Vitamin transmembrane transport 2 5 2.4909863831359056 0.0127389001928044 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0711332726649859 0.1349531130589082 0.0050347052047456 0.0334620993119388 +Vitamin transport 2 5 2.4909863831359056 0.0127389001928044 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.1114073342812727 0.2070995190727305 0.0191106391622076 0.1083207684216986 +Regulation of modification of synaptic structure 3 5 2.4898440634936674 0.0127799153294838 0.9368932038834952 4.138349514563107 0.8230686478854867 0.397984306488242 1.0338438306942168 0.6330579155507905 0.924823257495869 0.3057119359597413 0.0010343090391069 0.0039135152062846 0.0014512760162947 0.0009118158302113 +Entry into host 4 28 2.488876978253208 0.0128147299556073 7.968446601941747 31.24514563106796 0.6061616104105989 0.3954837799611526 3.566493820193545 3.4119437173329663 1.31706945612869 0.333413728218646 0.0760657989123155 0.0122106671185157 0.0730081455952705 0.4735789670016921 +Positive regulation of b cell activation 4 12 2.47925692022502 0.0131656434915652 3.092233009708738 11.186893203883496 0.1859276114166038 0.5045227221699764 1.8118375224733587 1.264344128777142 1.0073127631140006 0.3002532228225043 0.0163255968864409 0.0563311776114605 0.0706809399762649 0.0428945912137629 +Myelin assembly 0 5 2.475287762578066 0.0133128861648259 1.3810679611650485 5.334951456310679 0.6604549552139052 0.4058185332666181 1.1354528736988552 1.290157568299922 0.9729130679543696 0.2930816724161147 0.0892490045576324 0.1677870330809631 0.3703176202019055 0.6118721898827044 +Vacuolar acidification 5 9 2.474692493839564 0.0133350937436833 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 0.0847528009868792 0.0126574737404708 0.0085625102176751 0.0001429815632908 +Unsaturated fatty acid metabolic process 6 18 2.461211187629889 0.0138468832056377 5.094660194174757 21.366504854368937 -0.9535376445802276 0.2511883814851429 2.002006428286616 2.404313360486384 1.288801901636595 0.2466511013826314 9.981351289840813e-05 0.0013172485850202 0.0001755897066278 0.0025854516113679 +Response to zinc ion 1 5 2.457645619343621 0.0139851100331038 1.516990291262136 5.157766990291262 0.1744353093558431 0.4869472698842923 1.1003982817809728 1.2135412610654892 0.9723158637713488 0.2896585231159437 0.1026081339138497 0.191600110602388 0.0970188007029606 0.2898287915273368 +Protein processing 15 40 2.456307711124728 0.0140372903054393 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.4974171799485529 0.0447466679201601 0.0062977837798217 0.0011276322830495 +B cell apoptotic process 1 5 2.454160578526773 0.0141213906627724 1.837378640776699 6.223300970873787 0.0421343720865974 0.5045273347909794 1.4665397231387165 1.3683810775855545 0.9701682143804836 0.3008161188941299 0.0034296220851759 0.0126574737404708 0.0683566835720805 0.2166689846253057 +Response to oxygen levels 12 59 2.451330640930048 0.0142329146553559 12.5 62.737864077669904 0.8042614609462893 0.4659445696529398 5.042296826006319 7.106965221607376 0.959407798819026 0.3671515409983293 0.0145482469502443 0.0025308725508348 0.0937940742226618 0.0867030936510156 +Organic hydroxy compound transport 5 30 2.448756826690932 0.0143350191857993 7.145631067961165 30.32766990291262 0.3121985122058121 0.5028073494895335 3.2773354290298986 4.4061862301676955 1.0194405540894098 0.3270691777029814 0.0161886013519254 0.0039338834845355 0.0473555000798741 0.1594699798608763 +Protein insertion into membrane 6 27 2.4339890301828966 0.0149334476604532 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 0.2222355866483168 0.08610744549237 0.0001994135974024 0.0110551101007063 +Purine ribonucleoside metabolic process 3 8 2.432448694599237 0.0149971160182187 2.063106796116505 7.834951456310679 1.2047777662844132 0.2574288772305114 1.199068432200366 0.6246876870736083 0.9870596763535292 0.2611531847589775 0.0030581061915538 0.0005309775927247 0.0006049883657283 0.0078812527225172 +Ribonucleoside metabolic process 3 8 2.432448694599237 0.0149971160182187 2.1189320388349513 8.12621359223301 1.1914157696469383 0.2635896161542528 1.2648845164842024 0.7462477223524518 0.9827848183963048 0.2624193088278075 0.0060718409625537 0.0015052123544451 0.0023669228385379 0.0269295467729808 +Purine nucleotide catabolic process 2 12 2.422797486329171 0.0154015097956294 3.495145631067961 11.0752427184466 -0.1465591435845233 0.5584600526647061 2.4140518507304045 1.3244044968153963 0.846511325552401 0.2865173632813962 0.0155575631698287 0.0061250241039257 0.0665120453316815 0.2936288791787133 +Regulation of neuron projection development 13 64 2.421807546400474 0.0154435269666652 13.592233009708735 69.32038834951456 0.4627708713262993 0.6269884749906404 5.824182751460114 9.346058399998094 0.798447623110489 0.3496779713708587 0.0103631785157378 0.0468607453266787 0.1201774746361811 0.3426523181279696 +Positive regulation of lipid localization 2 12 2.414090142422856 0.0157745591765026 2.378640776699029 11.87378640776699 -0.052441312972462 0.4621434947628018 1.7058807755740677 1.980142250702998 0.9846466073226694 0.2640782192574804 0.0221396463904123 0.0748026769138462 0.102934709343467 0.1928878867570688 +Regulation of blood circulation 4 24 2.4111763797876185 0.015901156485454 6.468446601941747 25.968446601941743 0.2893551661274923 0.4907026879809681 2.9627910146791003 3.1161144766543267 1.01050030268827 0.311329637702479 0.0732573258319426 0.0017929291584427 0.067827568837072 0.2801050694708574 +Regulation of b cell proliferation 2 5 2.41034687070761 0.0159373600301697 1.7888349514563109 6.067961165048544 0.296043135362402 0.4569644069441661 1.2213996435499042 1.8129102062616271 1.0614819725849571 0.3010373616882123 0.0065792573185243 0.0237627189197599 0.1203326107508497 0.1188827437046941 +Antigen processing and presentation of endogenous antigen 2 5 2.40801382928975 0.0160395734299427 2.6529126213592233 6.463592233009709 1.0779744166035472 0.2832041157954688 1.4492771087670022 1.3990755299770097 1.00991421519493 0.2818848392729987 1.0 0.1349531130589082 0.3058660732099017 0.0334620993119388 +Antigen processing and presentation of endogenous peptide antigen 2 5 2.40801382928975 0.0160395734299427 2.638349514563106 6.390776699029126 1.097011591019633 0.2766562869747734 1.460743657586565 1.3760123823390067 1.0015631459591094 0.2785574288267012 1.0 0.1265462710440741 0.2887519731811417 0.0277461310389573 +Cellular response to oxygen containing compound 33 200 2.400694431698564 0.0163639948125173 38.092233009708735 202.30582524271844 -0.104291812421229 0.7706278434402465 13.372782017858617 21.819396934182247 0.5483231647406944 0.2810149562802034 0.0982802215262357 0.02226257076258 0.0075951591280263 0.1027435335951251 +Developmental maturation 10 38 2.4003042889563453 0.0163814480082067 9.04126213592233 42.12378640776699 0.2951074102250363 0.6104336491102619 3.871823327934924 5.43913517834949 0.8662608425150371 0.3328054790113054 0.5242424273097586 0.0562914471207365 0.2928508445992841 0.0608949836986924 +Cellular response to molecule of bacterial origin 5 27 2.3941514362456395 0.0166588690977693 5.966019417475728 27.81553398058253 0.5401337963874872 0.5564422286794936 2.8066859633222845 3.421796419175491 0.7983543896720936 0.3278075181218943 0.0009589376228415 0.0109207585727969 0.0210806858221783 0.070341535777627 +Negative regulation of cell projection organization 9 28 2.390983420163765 0.0168033116697781 6.281553398058253 29.016990291262136 0.4941593335808462 0.5349350626710885 3.4357274091046452 3.2317001852406393 0.8729841284160588 0.3226134265261706 0.1106003446312499 0.1006907935425077 0.3043555732784986 0.2015761752170554 +Negative regulation of leukocyte apoptotic process 2 5 2.386288752556324 0.0170193820921589 1.4368932038834952 4.827669902912621 0.5394724631500855 0.429843922437068 1.0942914798916792 1.2373285534927012 1.0763953212919928 0.3167022382829639 0.0055832614279084 0.0202898922491691 0.1046379555654025 0.0981468657129251 +Negative regulation of lymphocyte apoptotic process 2 5 2.386288752556324 0.0170193820921589 1.4368932038834952 4.827669902912621 0.5394724631500855 0.429843922437068 1.0942914798916792 1.2373285534927012 1.0763953212919928 0.3167022382829639 0.0030581061915538 0.0113213926532688 0.0617128865328283 0.0465653262864464 +Phospholipid transport 3 11 2.385983890394519 0.0170334971920573 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0257915242502586 0.0128487417044244 0.0336895534920958 0.1000707214680032 +Response to hormone 22 170 2.3824963747246355 0.0171957012948227 31.8495145631068 178.40533980582524 0.0990725127189358 0.7976167729201766 12.021488638464843 17.948909982077637 0.5617241006022542 0.2868912739823467 0.035059091570395 0.0221204417533753 0.0022116644691583 0.0686003296955893 +Pigment biosynthetic process 3 24 2.377984421524493 0.0174075613308508 6.191747572815534 23.20631067961165 0.1176426516349437 0.5124018007570521 3.0504861707649304 2.789310208180288 0.9995589703296716 0.3059733010449426 0.0014522342124754 0.0009611330378982 0.0241213389229544 0.0707827064406983 +Regulation of cell shape 9 31 2.374396776981392 0.0175776502590241 7.339805825242719 30.32281553398058 0.1353431361233448 0.6058324727524332 4.730203300416066 3.278373358632852 0.8844166611811607 0.3227574789293689 0.0966324665930835 0.0195066935662917 0.0439332506751067 0.0347305706128729 +Bile acid metabolic process 1 8 2.374264112610517 0.0175839676640818 2.5266990291262137 10.12378640776699 0.1243877745653704 0.5337541750520157 1.695730153673257 1.876455353117264 0.8649004571184868 0.275004846664166 0.1244478155008913 0.0274603336438859 0.1365592686609386 0.3798345415961738 +Transition metal ion homeostasis 7 24 2.37395595468827 0.0175986496578011 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 1.0 0.0415809882988902 0.0431485957349306 0.0397101526831211 +Regulation of smooth muscle contraction 1 5 2.3709223643913906 0.0177437577245509 1.1262135922330097 4.169902912621359 0.2781306853839073 0.5171960524441427 1.0854698919901893 0.9705703409287478 0.9780989466031628 0.3196844872181871 0.0055832614279084 0.0202898922491691 0.1046379555654025 0.3080842130268088 +Regulation of b cell activation 4 16 2.3623737772986875 0.0181583238147247 4.223300970873787 16.516990291262136 0.0577495350333673 0.5689697369892935 2.5301369502630555 2.1860552471506893 0.9138021371463246 0.3063589445117784 0.0380696669646128 0.1226746045160812 0.1927136822580191 0.1900400823135381 +Cellular transition metal ion homeostasis 6 21 2.3573333724288896 0.0184067139722048 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 1.0 0.1290920553826253 0.0706932691303836 0.0373784288289189 +Carbohydrate derivative transport 6 15 2.353329918241902 0.0186061175736473 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.0212633176973237 0.0096938597365547 0.0047209625021723 0.0062896490617296 +Response to manganese ion 1 5 2.351614621275973 0.0186921296591777 1.6237864077669903 4.803398058252427 0.1657661936697436 0.3714959689201358 1.1370705133968653 0.8633239594876049 1.253188844081787 0.2928478007224994 0.0619434524836269 0.0066572828402184 0.0376759114543004 0.1289341732663725 +Intracellular lipid transport 2 11 2.3508671368740583 0.0187297203093974 3.2475728155339807 12.529126213592232 1.0333463606041455 0.2805251274605093 1.854375285913986 2.478377603832177 1.0146678848168829 0.2521579143644115 0.1499686155438198 0.0038117145357013 0.0440381918347023 0.2143350029099695 +Regulation of lipid metabolic process 18 49 2.349522171039114 0.0187975245963771 12.599514563106796 52.890776699029125 0.2189053156740071 0.4007176079141414 5.562295027948738 7.005213895866115 1.3822804240908182 0.3523493088444139 0.0668312556722578 0.0367387848604647 0.1765070926790392 0.1374682538477908 +Muscle system process 8 55 2.347783371058618 0.0188855015407778 12.96116504854369 58.633495145631066 -0.1360433277549371 0.6683661193991334 4.943707052340472 7.051416191675887 0.7135692624477766 0.2987619019865341 0.0651780475785867 0.1086376771095568 0.0387077595304934 0.4364355977768958 +Glycerophospholipid biosynthetic process 16 34 2.3473447925010973 0.0189077488055797 12.407766990291265 39.55339805825243 0.6228968293784067 0.4586227574071144 6.110530292090928 7.803693618041913 1.233194093755117 0.3515784330467275 0.5474081709152836 0.7893446820396504 0.9009907870628896 0.1548265940088722 +Negative regulation of neuron differentiation 1 7 2.3427748791723086 0.0191409284736798 2.233009708737864 7.461165048543689 -0.1495079421232735 0.5679179654614803 1.7828954496469387 1.4617938846186531 0.8813245470493868 0.3066608596075524 0.1988423464133734 0.0693457394610891 0.2945150546099825 0.6495498386383816 +Negative regulation of fat cell differentiation 1 5 2.316736118646716 0.0205181107759528 1.2864077669902914 5.614077669902913 0.4976433633974675 0.4300670339742096 1.0728374992260008 1.3983679369791306 1.0544864134193073 0.3042453501941569 0.1457663642848915 0.0376249374527164 0.1789098805923502 0.4647244871500471 +Glycerophospholipid metabolic process 15 49 2.307877845719623 0.0210059315951376 14.597087378640778 57.060679611650485 -0.0519222534779674 0.4286122989812534 8.002292830543196 9.368077769293231 1.3877870839733877 0.3500560744701435 0.0798366046689081 0.3177879180268566 0.554432810088066 0.1278737873832776 +Ribonucleotide catabolic process 2 10 2.3073627852933987 0.0210346040574589 3.0533980582524274 9.12135922330097 -0.2406720954268502 0.5191406740024529 2.1137697210866273 1.3688029271896271 0.8886402861439604 0.285223748615374 0.0155575631698287 0.0061250241039257 0.0665120453316815 0.2936288791787133 +Regulation of cellular ph 7 21 2.303648994198113 0.0212423551963794 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.2145132052110039 0.0803922289273931 0.0296336619489011 0.0022658484440293 +Regulation of ph 7 21 2.303648994198113 0.0212423551963794 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.2260688267312995 0.0890100643743446 0.035832848893567 0.0033296386804888 +Vasoconstriction 1 5 2.298031696298616 0.0215599851927772 0.941747572815534 4.296116504854369 0.4550147295285651 0.4226344904456337 1.0175665119211763 0.8063368360820031 1.0118367013922955 0.2822569644550113 0.0937235599037543 0.0155240337321844 0.082298412398385 0.2531867173469597 +Intracellular protein transmembrane transport 5 21 2.2975240318668475 0.0215888937543344 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0013622028220488 0.0091243340822671 0.0224343496689777 0.020723717832043 +Modification of synaptic structure 4 9 2.2752114905326626 0.022893245902537 1.9902912621359223 8.087378640776699 0.8554193794108192 0.3851394739224027 1.562579058231813 0.6625457832358376 0.856660193170285 0.2984698193580089 0.0038211367015083 0.014058804472369 0.0099900975749504 0.0017429018144962 +Cytoplasmic microtubule organization 5 13 2.273620768536293 0.0229887976539282 5.54126213592233 16.283980582524272 -0.4057129541840621 0.5157598295914038 3.1454615725041517 2.514894597110268 0.9601707502093324 0.3182361626257836 0.2145132052110039 0.0803922289273931 0.3301049419756523 0.2132278663521486 +Regulation of sterol transport 2 9 2.267740402402988 0.0233450337780927 2.2645631067961167 7.949029126213592 -0.2660435952469734 0.4696867674075412 1.5281839445392789 1.3346844393150472 0.977377779136872 0.2786928507413737 0.0112943240362007 0.0398064357050217 0.0440381918347023 0.2143350029099695 +Lipid homeostasis 7 24 2.267060706851737 0.0233865174984062 7.665048543689321 25.939320388349515 0.8425417577103904 0.3366972259521467 2.992619034719237 3.7336969269092393 1.1648658675422845 0.295769208633365 0.3361355940595682 0.0082628338092705 0.0037355642696067 0.0188615730839656 +Positive regulation of blood circulation 1 5 2.2662216053576665 0.0234378184536585 1.6116504854368932 3.924757281553398 0.6685578971888424 0.3646934888838808 1.007091454748733 1.005648459742718 1.1685725886577618 0.3064822812176077 0.0619434524836269 0.0066572828402184 0.0376759114543004 0.1289341732663725 +Negative regulation of leukocyte migration 2 6 2.263867767292063 0.0235822489473997 1.5655339805825244 6.388349514563107 1.0839414642274992 0.2862432737648586 1.19995002173864 1.2770035444730965 0.9459956297737524 0.2624453160295969 0.0027067874988798 0.0100519320580488 0.0060877577335729 0.0397387250697101 +Modification of postsynaptic structure 3 7 2.263598827245945 0.0235988000532292 1.720873786407767 6.691747572815534 0.6941377574078058 0.4017689645559979 1.65090478681785 0.5210425083463128 0.996138198164031 0.3082748387049209 0.0017760204843955 0.0066572828402184 0.003279014583115 0.0027630263410089 +Protein localization to synapse 2 11 2.262638160251601 0.0236580037494711 2.216019417475728 10.259708737864075 0.4052272000352453 0.5200209112383006 1.792496680370015 1.8481236647516075 0.8799565434808945 0.299731001479056 0.1868885334554594 0.3339976348230559 0.6407106430015278 0.3340933889960909 +Regulation of t cell migration 2 5 2.256636168807792 0.024030818389739 1.5 4.483009708737864 -0.065072821388176 0.4977528624047557 1.1915967911258234 1.4303243809909685 1.0661805049889752 0.3090058258393087 0.0892490045576324 0.014058804472369 0.0752233407476578 0.0618109910728358 +Ventricular cardiac muscle tissue development 1 5 2.256330815458602 0.0240499208935509 1.6116504854368932 6.567961165048544 0.3904318214236652 0.4380253997625189 1.2578530769833427 1.487077905666335 0.9457728224791138 0.2556599469035547 1.0 0.0376249374527164 0.1789098805923502 0.4647244871500471 +Negative regulation of cell population proliferation 12 94 2.2540991192438304 0.0241899330751913 19.383495145631063 97.08252427184466 0.1581356625225672 0.7238624266901581 7.86528068228601 11.547200956886966 0.6889214696860141 0.3091925248352111 0.0457005105145347 0.0388307650763123 0.1684703491735009 0.7538978264368484 +Cellular response to nitrogen compound 23 130 2.2493507609335097 0.0244901886676147 29.37864077669903 133.67233009708738 -0.0913440289593822 0.7339643029629616 11.993620071702985 14.495292553830469 0.617621954267992 0.2893340104916694 0.5949379225820289 0.1925466019749329 0.0002869644067501 0.0133064494293104 +Cellular response to peptide 17 67 2.245860709357552 0.024712931241321 15.512135922330096 71.98543689320388 0.1339793674773638 0.7290046555586139 7.235453991765964 8.363395832893957 0.6604460800519434 0.2979149736137888 0.6648986183556902 0.1614233982158536 0.002508015807569 0.0209894270789441 +Maintenance of protein localization in organelle 5 14 2.238482166818468 0.0251896290733855 3.866504854368932 15.29368932038835 0.5637691386290394 0.4400793840085654 2.3676920099244176 1.9777055894707407 0.9564449590017818 0.2977236914910925 0.0112943240362007 0.0398064357050217 0.0440381918347023 0.0045924061823516 +Cellular response to hormone stimulus 20 117 2.237657291281283 0.0252434123844564 24.800970873786408 125.97815533980582 -0.0327223002801705 0.728838929110741 10.793480548848688 14.063724889312835 0.6408595623378146 0.2955097448881067 0.097689876298331 0.0565652756347362 0.0057720365614494 0.0676876130361948 +Regulation of leukocyte migration 8 25 2.234643626960505 0.0254407542776466 6.080097087378641 26.6504854368932 0.4712165673240142 0.5560717407414059 2.980664549328318 3.842679935245632 0.8934424673809059 0.3310773445531978 0.0054233896663051 0.0052630916622981 0.0307925237330937 0.0085099687642093 +Organophosphate ester transport 6 23 2.234032039976825 0.0254809649774294 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0571768496395965 0.0402942577421927 0.0116807824112378 0.0372497576367333 +Organophosphate metabolic process 50 238 2.2294199397725403 0.0257859767384152 55.949029126213595 249.15533980582524 -0.4369782428024337 0.6503033096450813 19.79432653906351 23.474529589485684 0.7664088919220757 0.3242541559261604 0.0361229413872567 0.0199913579497765 0.0934776878727529 0.0049873496569405 +Purine containing compound salvage 2 7 2.2276062222897437 0.0259067853765528 1.8737864077669903 7.233009708737864 0.7743343410521683 0.3736672462346809 1.748395167894324 0.8238423298008908 1.0837559690437977 0.3116170205148165 0.0015075035399645 0.0056684159955205 0.0025675639060761 0.018020673376298 +Chemical homeostasis 29 171 2.22535934119092 0.0260571247226641 43.762135922330096 177.7597087378641 0.7082111793088889 0.511106347874914 13.668464281922288 17.87763227716401 1.3204137511810292 0.4179418895476048 0.2920335137981538 0.0178547225517254 0.0275140641907449 0.0997488791209369 +Purine deoxyribonucleotide metabolic process 2 5 2.2226562920722484 0.0262389852722875 1.4587378640776698 4.259708737864078 0.3549497635304336 0.4294218585197534 1.1237706807597552 0.8966106149148685 1.1035228423894563 0.3141848936342102 0.0619434524836269 0.0066572828402184 0.003279014583115 0.0225979674873623 +Response to food 1 5 2.2215472831062133 0.026313915901678 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 0.0619434524836269 0.1180585699575878 0.0376759114543004 0.0225979674873623 +Regulation of muscle system process 4 30 2.2204224622725093 0.0263901036750475 7.985436893203883 32.44660194174757 -0.3188005989864352 0.6004504328737817 3.6675937924748503 4.6425180549022445 0.8156039427307803 0.3196488796492143 0.0139189683537814 0.0172011735219368 0.1020214636350951 0.3840459553368933 +Negative regulation of type i interferon mediated signaling pathway 0 5 2.217118119685264 0.0266150209005608 2.162621359223301 5.483009708737864 -0.0230452746820418 0.5794347398886982 1.5904023189881271 1.2665229022965443 0.8389535891988721 0.292356529432894 1.0 0.1265462710440741 0.2887519731811417 0.5020158400168588 +Regulation of anion transport 2 10 2.216991075630822 0.0266237013822143 3.657766990291262 11.50242718446602 0.7713855446015195 0.3761489496061844 2.0089273726107977 1.6987985280405251 0.9512307489218268 0.2850669663772418 0.1499686155438198 0.0398064357050217 0.0440381918347023 0.2143350029099695 +Cell maturation 6 21 2.214818065107673 0.0267725547491892 5.558252427184466 23.611650485436893 0.3784230404296081 0.5141541830151944 2.6030237932680045 3.55055857689134 0.9250478571653724 0.3120408106541015 1.0 0.0511594720034292 0.3481728902143282 0.1291991657738266 +Mitochondrion organization 35 176 2.2133587972358817 0.0268729189255385 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 0.0189140759890556 0.0088225567521705 1.6340187406473237e-05 1.1062687925040106e-06 +Maintenance of protein location in cell 10 19 2.213019751603177 0.0268962839445983 4.963592233009709 20.74757281553398 0.5138976626555444 0.4828559702191822 2.90064182866346 2.9061984196552437 0.947299732036647 0.3164077327541715 0.0239365913087713 0.0803922289273931 0.1130565151476282 0.0302802497568866 +Type i interferon production 7 27 2.2065305934642656 0.0273468705892321 6.808252427184466 25.796116504854368 -0.1477826557617209 0.6734225567884852 4.037401578874221 2.740771712248145 0.6606019168156112 0.2736459887317027 1.0 0.4876012483283494 0.0061372441903375 0.0058898561186024 +Positive regulation of multicellular organismal process 35 188 2.206160513924459 0.0273727629059599 39.01699029126213 197.18446601941747 -0.1485555770791877 0.7987469369478079 12.944136981807215 18.82443030137102 0.4614700428477258 0.2559274460276268 0.2539261966081534 0.3531581396255051 0.0465415347964552 0.1929219235750479 +Response to insulin 10 57 2.2052665750107736 0.0274353938894478 13.133495145631068 61.12864077669903 0.0882163252533028 0.7449465367842997 6.212588568060487 6.874072230221212 0.6076890330045615 0.2809929302544454 0.5800983581755315 0.2368742482286771 0.0033094015221552 0.0454212632467114 +Regulation of membrane potential 8 55 2.204404976864756 0.0274958759826691 12.04611650485437 57.75970873786408 0.1124751219273164 0.6676030681415518 5.082838961521082 5.41286026291516 0.7215479250938304 0.3068872738743891 0.18840613689087 0.0197999377646971 0.1948775203502228 0.3878767508375655 +Chemical synaptic transmission postsynaptic 2 11 2.202594569201993 0.0276233370388137 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 0.1583124314184509 0.0443091130960601 0.2051784324027348 0.2403376761227438 +Regulation of postsynaptic membrane potential 2 11 2.202594569201993 0.0276233370388137 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 0.1624541869963563 0.0466281418945222 0.2140290435859761 0.2535314416198171 +Response to acid chemical 5 23 2.1971943420299382 0.0280065695199602 5.114077669902913 21.817961165048544 0.5197326923555237 0.5655380022552302 2.7701767974468736 2.8512248634214767 0.7871134488658174 0.3217866346203445 0.0085356676981486 0.0497306095082375 0.0558070993489551 0.123629346148218 +Cellular response to camp 2 6 2.196830717868936 0.0280325383623443 1.6019417475728157 5.065533980582524 -0.1953998899771133 0.4214681310513395 1.2034723695122669 0.805368188314036 1.1508648793217675 0.2996934524264009 1.0 0.0255840399150975 0.0237046415332288 0.1298078118605267 +Neuron recognition 0 5 2.1931670960299434 0.0282953422796232 1.9368932038834952 6.189320388349515 0.7447638338644241 0.3705616592284931 1.1064234596616862 1.175429078554095 1.011644937344681 0.2892876339238009 1.0 0.2372212797486779 0.494366254766713 0.7522555648072834 +Regulation of response to extracellular stimulus 1 5 2.1897262960622808 0.0285440928040654 1.0364077669902914 4.466019417475728 1.2416795343104177 0.2058666180593168 0.8221064046230258 0.7766686887277909 1.0462594039989206 0.2178110962907249 0.0526645480715484 0.1008375048293403 0.0274146616230463 0.0968157430558884 +Protein insertion into mitochondrial inner membrane 3 7 2.186645150059275 0.0287684386131874 2.45873786407767 5.665048543689321 0.6692509200083531 0.3406754428009103 1.501050234026552 1.645659707056692 1.2686438529444872 0.3125184360343283 1.0 0.1094892401774078 0.0001383364889708 0.0019884945269669 +Proteolysis 107 362 2.1859721904060856 0.028817639974648 82.13349514563107 384.1650485436893 0.3937128320128939 0.7591937859483255 23.57335472164496 35.5242559243431 1.030244592288769 0.3605545225308969 0.1524379162404655 0.0004605421567341 0.0850320803473189 0.0189809255944945 +Response to camp 3 10 2.179547711195581 0.0292910043632776 2.3228155339805827 9.390776699029129 -0.0351085811697283 0.5424294537007721 1.6751072520224228 1.068168007330424 0.8972970563898698 0.2965352321592767 1.0 0.0693457394610891 0.0931972749461429 0.1732034237667374 +Positive regulation of organic acid transport 0 5 2.177409952292124 0.0294499937847421 1.8567961165048543 5.946601941747573 0.3622827495700632 0.4822345019026507 1.3799456254886664 0.9358362164790908 0.9715216605110036 0.3096986355133196 0.0619434524836269 0.1180585699575878 0.2712176839291556 0.4765717690882453 +Negative regulation of neuron projection development 5 18 2.1726695449424445 0.0298051975232886 4.944174757281553 19.932038834951456 0.8070712719008988 0.4165241941447024 2.3357271686464363 2.7475042016888107 0.8484003015222881 0.3001902418041021 0.0597604037758126 0.1827953867238 0.3085284241617345 0.1995460919996873 +Glycolipid biosynthetic process 1 7 2.171645602029216 0.0298824045600789 3.3009708737864076 8.701456310679612 0.8778541677747596 0.2891249509557468 2.0940737065519093 2.1465026455410077 1.206628042966233 0.2848826766737565 0.1624541869963563 0.0466281418945222 0.2140290435859761 0.5274882304980407 +Regulation of lipid transport 4 18 2.169646093888264 0.0300336666560099 4.084951456310679 16.67718446601942 0.3665821344953645 0.5500608719110902 2.096012568417446 3.1783802180721676 0.8243482455883206 0.2999534514421824 0.0034245890280422 0.0029226642017144 0.0163696820911607 0.0298513421744587 +Ion homeostasis 18 99 2.169091851367999 0.0300757112231577 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.4878936714230979 0.0999758443946052 0.104089597721008 0.1874121323382686 +Histone h4 k20 methylation 1 5 2.1654986392622866 0.0303495194925016 1.8179611650485437 4.543689320388349 -0.2486405071538078 0.5170633906397567 1.4307197314457356 1.3971308952383936 0.975747481570383 0.3091193158254727 1.0 0.1094892401774078 0.2532529321952443 0.1125747569923622 +Regulation of tube size 2 11 2.161644280117123 0.0306456055739088 2.325242718446602 10.861650485436892 0.4663835105130179 0.4051459652205314 1.5156285149919448 1.9062455332877175 1.0707303124706984 0.2893702596977744 0.0204019662414969 0.0091243340822671 0.0931972749461429 0.3744563663843071 +Deoxyribonucleoside triphosphate metabolic process 4 9 2.158710627638152 0.030872623765062 2.3106796116504853 8.283980582524272 0.37885565145774 0.3611791401950917 1.8009119923381658 1.1145270578724225 1.2279981659947377 0.2841942772074602 0.0619434524836269 0.0066572828402184 0.0001960616495152 0.0002457979454447 +Gmp biosynthetic process 1 12 2.15779248875196 0.0309439691423751 5.487864077669903 12.216019417475728 -0.2136784453243963 0.4368939162536698 3.5317352236914625 0.6963397226438397 1.1565056526524748 0.3115850466790157 0.0619434524836269 0.1180585699575878 0.0376759114543004 0.1289341732663725 +Cation transport 20 143 2.150892982279254 0.0314846475820778 40.9247572815534 152.4733009708738 1.0106305648473772 0.4693050539746304 15.98502541638414 15.374508146736815 1.5607432077940149 0.4143686874753333 0.0950213330344316 0.0207966076301852 0.0901962789612799 0.4568310485412113 +Response to oxygen containing compound 43 270 2.1491772262866604 0.0316203538413195 48.78155339805825 273.7669902912621 -0.0414966249474367 0.8246448164404616 15.813256375541531 28.130056441601266 0.4928006342114703 0.2648986811695466 0.136800183211478 0.0416132911757745 0.0198131983377303 0.1356531706489318 +Protein lipid complex subunit organization 1 5 2.1461850578400665 0.0318582172242383 1.1310679611650485 5.281553398058253 0.8340606377827192 0.3186795511043827 1.091585568626531 0.8580569122292387 0.9998971723912514 0.2555622550899711 0.0892490045576324 0.1677870330809631 0.0752233407476578 0.2348875720984273 +Positive regulation of cell activation 10 38 2.143536140687148 0.0320700722963516 9.66504854368932 41.58980582524272 -0.0344461667002542 0.6127678592935748 3.990819774604169 3.7854079772897897 0.9017662407322792 0.3302397387818446 0.0414674769679191 0.1918302178058925 0.1767695438949403 0.0797951006545679 +Muscle adaptation 3 13 2.138866459859876 0.0324464850924777 3.825242718446602 15.776699029126211 0.2709182626781788 0.6170505472035889 2.4312974859855383 2.86655315102807 0.7483421945174314 0.2900515938756093 0.2260688267312995 0.3955810682553247 0.1289094914142556 0.2447590412697401 +Purine nucleoside biosynthetic process 2 6 2.128765255273288 0.033273686874466 1.4611650485436891 5.742718446601942 0.8935109670252933 0.3592786141720023 1.2698698816998135 0.508968486969168 1.0201063575252725 0.3098922359465458 0.0010343090391069 0.0039135152062846 0.0014512760162947 0.0105668672564949 +Regulation of biomineralization 1 5 2.125598349367716 0.0335367171773151 2.0 7.254854368932039 0.7087493386381231 0.4293372114928327 1.648771240027478 1.7124900192906916 0.7924172542279996 0.2810900644904195 1.0 0.3530974878629287 0.6660978714719568 0.6495498386383816 +Ceramide transport 2 5 2.1231045482643864 0.0337450919794652 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.0619434524836269 0.1180585699575878 0.0376759114543004 0.0225979674873623 +Positive regulation of protein binding 8 24 2.1183044552731043 0.0341492915663659 5.099514563106796 23.00242718446602 0.3155864476850776 0.5869976520948652 2.6175842559823277 2.8459635752908654 0.8435085117004013 0.3185282020054304 1.0 0.0254749821013702 0.0739031601884657 0.0401410360295106 +Neurotrophin trk receptor signaling pathway 4 5 2.116949390205788 0.0342641432713459 2.313106796116505 5.66747572815534 -0.1413624702694373 0.4615946426465154 1.411300804034482 1.2222096958676991 1.0502739438284965 0.3035060076734568 1.0 0.1515272625734178 0.0072626368836444 0.0465653262864464 +Purine ribonucleoside salvage 1 5 2.1144546894903 0.0344764508435089 1.194174757281553 5.087378640776699 0.7525597745497481 0.4015392353821809 1.3351720912111715 0.2990858602087254 0.9698061350109142 0.3038187137036782 0.0290719737908623 0.0563150378970086 0.0080925194523707 0.0309764532364539 +Nucleoside salvage 1 5 2.1144546894903 0.0344764508435089 1.194174757281553 5.087378640776699 0.7525597745497481 0.4015392353821809 1.3351720912111715 0.2990858602087254 0.9698061350109142 0.3038187137036782 0.0385773062479974 0.0743799864466655 0.0146338936924203 0.0542215392640632 +Positive regulation of necrotic cell death 1 5 2.106149730541051 0.0351913481764643 1.577669902912621 5.262135922330097 0.5638344924795549 0.4335998879538771 1.168471912149588 0.9650309623137224 1.027471527178098 0.3152978961085739 0.0479914252810258 0.0921025797166938 0.2159896916124382 0.0817606313480972 +Cytokine production involved in immune response 3 9 2.101216068299453 0.0356220035144332 2.441747572815534 11.356796116504857 0.4093967072187203 0.5138902009456215 1.857549501324998 1.803819417905269 0.799103762168713 0.2723815630799965 0.1908924307699622 0.3404254693467198 0.2766090590544724 0.1542690309953486 +Regulation of nervous system process 2 11 2.099876231530936 0.0357397301053188 2.6941747572815533 11.186893203883496 0.709685710886722 0.4267375683332639 1.6891041598029932 2.2483053074671338 0.9287991925104498 0.3050882814355576 0.2260688267312995 0.0890100643743446 0.1289094914142556 0.466104033566582 +Positive regulation of protein polymerization 2 27 2.0961594261531444 0.0360680508495174 8.29126213592233 29.067961165048544 -0.1407148677954534 0.5820281683314947 5.027364087585942 2.9976111392542504 0.9226797177142148 0.3196707976657912 0.046072228335376 0.029653655190088 0.2366877859381625 0.4437143289312975 +Negative regulation of immune system process 8 40 2.093287768960868 0.0363234738247439 10.262135922330096 46.91019417475728 0.2444799455656694 0.6277319776406994 4.757132947946456 7.065174604728879 0.8023664740567815 0.321929768279026 0.2080546526177427 0.0850908093349036 0.2369690366527296 0.4647372262570938 +Maintenance of location in cell 16 39 2.092987722236185 0.0363502505770685 9.635922330097088 42.1747572815534 0.2649647199662676 0.5798575457499338 4.236740695643613 4.719670023980757 0.8590313096955686 0.3222710831931881 0.1332928413805449 0.3561708686960925 0.3809458484999473 0.1003011935434931 +Phosphatidylserine metabolic process 1 5 2.092178881662405 0.036422516893432 1.6116504854368932 4.798543689320389 0.5449831042779167 0.333458204805222 1.1531553142618924 1.1765086639888198 1.1706570072177929 0.2634993979961211 0.0756950383436983 0.1432798584585485 0.0553069748090555 0.1807018090276839 +Ether biosynthetic process 3 5 2.0905515148157563 0.0365682859229621 2.279126213592233 4.927184466019417 0.4312886834031472 0.4962399070037939 1.3837655160783582 0.5481999094578265 0.9002858560873801 0.3118323573140075 1.0 1.0 0.2159896916124382 0.0817606313480972 +Anion transmembrane transport 8 36 2.0889392249827536 0.0367131943290379 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.4251307382490726 0.6629984443692342 0.0182150286968447 0.0452876692762686 +Positive regulation of chemokine production 3 7 2.088476440319289 0.0367548784526867 1.703883495145631 7.002427184466019 1.1308330497685224 0.261365768238967 1.2206493839204828 0.948936007151574 0.9251734036107908 0.2478284645013121 0.1070183553885475 0.0202898922491691 0.0170176746213231 0.0233101974365333 +Vascular associated smooth muscle cell proliferation 3 11 2.08567632399947 0.0370079524864044 1.9781553398058251 9.95631067961165 0.2612945272901553 0.5549650568227408 1.9275741823070591 1.137632518934991 0.7984220228563544 0.2742372848237238 0.1457663642848915 0.0376249374527164 0.0068941903455315 0.0674365169251515 +Sensory perception 14 35 2.0845131068359946 0.0371135192636147 8.587378640776699 35.48300970873787 0.2801501425459651 0.4439497622713729 3.631661729137722 5.322347342377745 1.1543967333771397 0.3256888258772134 0.5758772071007734 0.2317711545672773 0.2369690366527296 0.4647372262570938 +Neutral lipid biosynthetic process 2 6 2.081539459452948 0.0373845562202341 2.1067961165048543 6.288834951456311 1.1186547336258812 0.1821371148552785 1.2515048910859687 1.3298556757746482 1.2887117600293918 0.213034599641239 0.0076498462283805 0.0274603336438859 0.1365592686609386 0.1410707299584872 +Negative regulation of signal transduction by p53 class mediator 2 5 2.0805156736900465 0.0374782595283662 2.1262135922330097 6.490291262135922 0.0025135391117914 0.5277846023571443 1.4626721898500985 1.409882909350627 0.9389842991964372 0.2948801347666068 0.1157751708195439 0.2147385524083838 0.4559893986318888 0.1188827437046941 +Regulation of membrane depolarization 3 7 2.076201788835694 0.0378752919122589 2.516990291262136 7.686893203883495 0.0350478606542097 0.5368103099599445 1.9563694009351733 1.8385101234509107 0.9264070314419856 0.2972912730242556 0.0981765691424607 0.1837383274168749 0.0895680133917324 0.0790607116166092 +Negative regulation of smooth muscle cell proliferation 2 8 2.075700320672336 0.0379216762759822 1.3932038834951457 6.900485436893204 0.4400043471945363 0.4614539561465798 1.2962801249402136 0.9411311915407056 0.903186622818406 0.2725223910156518 0.1157751708195439 0.0237627189197599 0.0213395532455881 0.1188827437046941 +Porphyrin containing compound metabolic process 3 16 2.0729172483335474 0.0381799815197061 4.91747572815534 16.531553398058254 1.0269348271542438 0.279733852070357 2.276512713100022 2.089380108414912 1.2578863722796805 0.2914421038569487 0.012648542478749 0.0045096021611559 0.0094917115905994 0.0257423149537502 +Response to ketone 7 37 2.0682668605784658 0.038614936166256 8.135922330097088 38.38592233009709 0.3161441476593932 0.5684563546193468 3.4607326899442756 4.1947836161356875 0.8306352296989162 0.3114696972884839 0.0154102901166228 0.0837371519329494 0.0439332506751067 0.1482732403897816 +Negative regulation of defense response 8 32 2.0667272464914883 0.0387598622737033 6.924757281553398 32.34466019417476 0.3561607180123788 0.5888237141063734 3.4481835219839927 4.979340389024908 0.80507298525878 0.3146610297306706 0.4279811411777856 0.0948939281427919 0.1359181537943466 0.097972574862474 +Cytokine production 17 90 2.065551318148037 0.0388708651665763 18.97087378640777 96.13106796116504 0.0824735848580317 0.7508975178485808 7.48909409104055 11.178920255675855 0.680456448776925 0.3062861740716413 0.4846873920497683 0.3919723151155029 0.0551325587487618 0.1804346191755573 +Prostanoid metabolic process 5 12 2.0651681031449347 0.0389070974126424 3.781553398058252 13.131067961165048 -0.261723242286546 0.3706172000065809 1.570619046394198 1.5586606851087283 1.1874779925532215 0.2609303218723489 0.0002365528693072 0.0016986126979642 2.1849572487781167e-05 0.0010205277760807 +Positive regulation of toll like receptor signaling pathway 1 5 2.064125452161141 0.039005823321065 1.2936893203883495 5.031553398058253 1.0578528534380236 0.3141679357263049 1.0138166762254122 0.5543075051408229 0.7960587950562075 0.2703423316965778 1.0 1.0 0.3225700131084155 0.1807018090276839 +Ether metabolic process 6 8 2.0641132304535 0.0390069818233129 2.3009708737864076 8.116504854368932 0.6936598083237113 0.3993528168351505 1.8983127483146185 1.066260782267489 0.9725930071190376 0.2989456029254039 0.0847528009868792 0.1596960736798767 0.0683566835720805 0.0539281835546241 +Membrane lipid metabolic process 12 33 2.063508300450022 0.0390643599988478 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 0.020861421503252 0.028278569718715 0.069075924595368 0.031258877920322 +Positive regulation of lipid storage 0 5 2.06236316378134 0.0391731735826752 1.0218446601941749 4.87378640776699 -0.0461985583446553 0.3860078033766009 0.9306060741204804 0.5605062145188762 1.1283790470996855 0.2530202324700385 0.066549445548378 0.1265462710440741 0.2887519731811417 0.5020158400168588 +Cellular response to peptide hormone stimulus 10 58 2.0595706894279817 0.0394396006967492 14.33495145631068 62.47330097087379 0.0414662019259755 0.7184179492080863 7.422377719913005 7.616204350937662 0.6555256790521736 0.2907743466541715 0.6005942358150713 0.2626663455857818 0.0050372694265172 0.0661575497747017 +Protein import into mitochondrial matrix 1 9 2.057740862910024 0.039615015546601 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0023758658868836 0.0088504827764808 0.0491545726752397 0.0334620993119388 +Triglyceride biosynthetic process 1 5 2.052923070742541 0.0400800391035409 1.4757281553398058 5.274271844660194 0.8957176915704722 0.2655240444557116 1.2274740041869927 1.2502497629633054 1.1422343750332298 0.2371147384530898 0.1070183553885475 0.1993869387044997 0.4288068787284576 0.3080842130268088 +Neurotrophin signaling pathway 3 6 2.0514053284489155 0.0402274905847974 2.575242718446602 7.002427184466019 -0.28448872562993 0.4069596024308462 1.5206247723778896 1.4523145009764389 1.1265258568879903 0.2927189797017976 1.0 0.0202898922491691 0.0020099112654694 0.0233101974365333 +Deoxyribonucleoside triphosphate catabolic process 2 6 2.050409512648826 0.0403244856843172 1.3131067961165048 4.985436893203883 0.3582467332448406 0.3438147591003742 1.2253483983473652 0.7035151362894804 1.2506842424472815 0.2759561596807582 0.0338360956076009 0.0018609890552042 0.0004465916791071 0.0034377129995212 +Nucleoside triphosphate catabolic process 2 6 2.050409512648826 0.0403244856843172 1.3592233009708738 5.189320388349515 0.3719370715760305 0.3456734136720462 1.2645607774422765 0.8802484888971264 1.242145009747497 0.2750576734874809 0.0479914252810258 0.0039135152062846 0.0014512760162947 0.0105668672564949 +Glycoside catabolic process 2 5 2.049726208213926 0.0403911560182699 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 0.0385773062479974 0.0743799864466655 0.1768749528600843 0.0542215392640632 +Nucleobase containing small molecule biosynthetic process 2 7 2.0482551956520427 0.0405350006466771 1.7135922330097086 6.725728155339806 0.7645590390237343 0.3868941709719335 1.5487262880443011 0.5167281344531495 1.0510813905138674 0.3156372982117756 0.0017760204843955 0.0066572828402184 0.003279014583115 0.0225979674873623 +Glycosyl compound biosynthetic process 2 7 2.0482551956520427 0.0405350006466771 1.7621359223300972 6.927184466019417 0.7674599123201137 0.3848892158216302 1.5816678247150102 0.68587612099484 1.0539983320068638 0.3161304697180149 0.0030581061915538 0.0113213926532688 0.0072626368836444 0.0465653262864464 +Response to organic cyclic compound 25 164 2.0427444692734653 0.0410777402302151 30.196601941747577 169.66990291262135 -0.013234098749256 0.7860356956851513 12.68370593400014 16.207326851763508 0.5484100854921776 0.2781123252291441 0.0925631729249488 0.0470977808811681 0.0284818588153905 0.0374344985409876 +Cellular monovalent inorganic cation homeostasis 7 24 2.026095649868356 0.0427549838041141 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.2597451867723493 0.1163398228410075 0.0585952346233336 0.008913025090531 +Tetrapyrrole metabolic process 3 18 2.02608747764037 0.0427558211037455 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.0195557545343205 0.0085749794431607 0.02082153573846 0.0605931687414638 +Regulation of ruffle assembly 4 8 2.0243016149984907 0.0429391275706221 3.563106796116505 7.706310679611651 -0.1896001725095857 0.587027917065476 1.9228816507948483 0.5339530001702399 0.7949627142479727 0.2950991488494798 1.0 1.0 0.0895680133917324 0.0028145739091465 +Fatty acid derivative biosynthetic process 8 13 2.019756534787531 0.0434086476994388 3.667475728155339 14.54126213592233 -0.3314344595453453 0.4141934456805068 2.587987642130202 1.6940060978166809 1.0484306531566097 0.2629372897270916 1.0 1.0 0.1617118829485157 0.1766336232289773 +B cell proliferation 4 8 2.0196417606972967 0.0434205601258192 2.3567961165048543 8.825242718446601 0.1517755374331337 0.52012865384349 1.586159013069686 2.01295408899178 0.9393051152847148 0.2960682826562936 0.0119629297909749 0.0420348553288257 0.1963700434786238 0.0807266025333323 +Positive regulation of anion transport 1 6 2.017454436404291 0.0436481113419695 1.9344660194174756 6.878640776699029 0.6741621787536862 0.3772632196525015 1.2764013643913412 0.9602943000993394 1.0188817387556033 0.2883605125622093 0.0756950383436983 0.1432798584585485 0.0553069748090555 0.1807018090276839 +Regulation of neuron differentiation 2 20 2.0174098352652923 0.0436527617354387 5.286407766990291 20.160194174757283 -0.0173168065481275 0.5555762040934534 3.9079840740523073 2.6196731362780623 0.963059918132658 0.3115826074576115 0.0996898015200429 0.0873897608331362 0.4890621029119328 0.9047542689165794 +Negative regulation of vascular associated smooth muscle cell proliferation 2 6 2.0144609496371397 0.0439611608063461 0.9393203883495146 4.975728155339806 0.4817713646854316 0.4304105931495651 0.99205950547326 0.8240282325516696 0.9592701136788652 0.2771677993295702 0.066549445548378 0.0077184558590264 0.0040998381065295 0.0277461310389573 +Negative regulation of smooth muscle cell migration 2 6 2.010232289591784 0.0444066094260158 2.162621359223301 5.334951456310679 -0.2920508359570167 0.4737310539289996 1.4632258956428108 1.0308078402247205 1.0355360631589272 0.3113659433132448 0.0711332726649859 0.0088504827764808 0.0050347052047456 0.0334620993119388 +Membrane depolarization 4 10 2.004789700238903 0.0449855341162641 3.2815533980582523 10.604368932038836 -0.23027860289964 0.5538169301459358 2.207302424843833 1.825195917082276 0.8609514580447869 0.2904236451628909 0.1457663642848915 0.266209970857853 0.1789098805923502 0.2015708610705285 +Carboxylic acid transport 6 28 2.000514224344088 0.0454447655036374 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.093603257631803 0.2676422850845579 0.1084258215337314 0.1374763991753785 +Bile acid biosynthetic process 0 6 1.999918010887734 0.0455091179650954 2.621359223300971 7.864077669902913 -0.0520911036122666 0.6187748349847819 1.8505654074550568 1.5347024232560422 0.773278262832708 0.2901542808691608 0.0937235599037543 0.1758008751515455 0.3854765258786279 0.6307503726508297 +Regulation of viral transcription 1 5 1.9996947470404411 0.0455332357642177 2.058252427184466 5.33252427184466 -0.2370554914447475 0.4868147003845069 1.4834049177054625 1.3433079141892594 0.9701248108398718 0.288418377602304 1.0 0.1432798584585485 0.3225700131084155 0.1807018090276839 +Inflammatory response 18 63 1.9980766386449065 0.0457083520172711 13.228155339805824 68.3883495145631 0.4116983048649594 0.5194837377797665 5.6022172704029956 8.769134982645609 1.0984550499812151 0.3566163019943059 0.0473074236053336 0.1306918746338448 0.0735625451130406 0.0855014239852513 +Apoptotic dna fragmentation 0 5 1.992211910919336 0.0463478119191353 0.9927184466019418 4.233009708737864 0.4340356244646851 0.5108231271875565 1.0251428450545412 1.3049858348012648 0.9254843459004916 0.3195497922884586 0.0526645480715484 0.1008375048293403 0.2348471946143729 0.4217257773445009 +Leukocyte differentiation 17 56 1.991586537869912 0.0464164416466388 13.259708737864075 62.82281553398058 0.2230074329146526 0.6311707774623282 5.891661699815195 7.755058720737631 0.8147397072079771 0.3290680435049292 0.1424807372838079 0.1142179519295345 0.1937411646884055 0.3168450002101647 +Neuron apoptotic process 11 49 1.990172580734299 0.0465719276498601 11.191747572815531 49.65533980582524 0.9007291731588002 0.4299023129629146 4.0102574614548505 4.518854312987721 0.9862249081516458 0.3541854094791909 0.163845303256872 0.0540831694948363 0.0262969294295583 0.0277218886109379 +Phospholipid dephosphorylation 3 5 1.9885714699085504 0.0467485230726179 1.5097087378640777 5.133495145631068 0.2642559626879384 0.5011003069511705 1.1373632053119338 1.5592332001039908 1.0020710614418686 0.3103616798127063 1.0 1.0 1.0 0.4808786474245576 +Membrane organization 30 206 1.9848935871819129 0.047156312021318 62.02427184466019 223.60922330097088 0.9560408776070136 0.5603311757674675 21.467957454898308 21.375973545731355 1.611091026762519 0.4273954777865132 0.0435336356078595 0.0303548027508535 0.000924555842774 0.0010737392119654 +Iron ion homeostasis 5 18 1.977665629507872 0.047966440109036 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 1.0 0.08610744549237 0.0336895534920958 0.0359869143678365 +Nucleoside phosphate catabolic process 3 19 1.9709737822961009 0.0487268747260489 4.604368932038835 18.655339805825243 0.0962143819400473 0.5415770686805816 3.4056321626088666 2.256091136153212 0.9847714139711842 0.3121628759754123 0.0369748680428621 0.0216384292134882 0.0615073416932102 0.3549921005266846 +Biological process involved in interaction with host 4 48 1.9702485637315637 0.0488098902470799 10.618932038834952 53.64563106796116 -0.1735979361033036 0.5744529678567812 5.9122163164147095 5.1849909737500735 1.0319123463248503 0.3347248046760931 0.1299869053709053 0.0077260891597347 0.0879662178978236 0.5939336215901803 +Antigen processing and presentation of exogenous antigen 3 7 1.9650400525398912 0.0494096020226777 2.0800970873786406 7.682038834951456 0.7846141280949802 0.3912377722563422 1.42818099743969 1.069601013737802 0.957994485343778 0.3040877622263243 1.0 1.0 0.4559893986318888 0.0308662830144804 +Response to wounding 9 69 1.9635362352501509 0.0495838983663019 14.859223300970871 77.98300970873787 0.2907833523091244 0.6653892827271913 6.777288412904535 9.76879332264166 0.7686640367654125 0.3260596058790733 0.0611764564974782 0.168213828396044 0.4477842596102421 0.7215209030078719 +Phospholipid biosynthetic process 14 48 1.9623344216614256 0.0497235621914469 15.191747572815531 54.88834951456311 0.3601791313916425 0.5325104042072244 6.85810624136386 9.315774292776531 1.1122724170508866 0.3517335331311575 0.6182001151651297 0.8491879482379903 0.9499304858534032 0.0895267709622813 +Male meiotic nuclear division 1 5 1.9618266962047528 0.0497826644701238 1.2475728155339805 3.7354368932038833 0.0494577322344068 0.525941709048392 1.1090400519958274 1.1805077702125029 1.0220628651916135 0.3139728511824374 1.0 0.1837383274168749 0.0895680133917324 0.2715157705871365 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..989f9b99708c033e7c6f463aabf2ed0faa94acb3 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 6356, + "title": "Average number of proteins per term", + "value": 18.411736941472626 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6d7e933180c2117744fdf0253eb926553bea2280 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fa906aea932b01cc2739586f587b63de7fcabed3 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,2212 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lipid metabolic process 0.4388970159869195 5.260300523262783 1.4382015037147677e-07 0.0009137032602342 0.0002711829356974 259 P30536,Q9BZF3,Q8N4Q0,Q6P1A2,Q8WTV0,Q8NHP8,Q9HCL2,Q9BWD1,Q14849,Q15125,Q8NCC3,P07099,O43681,P35790,Q14914,O15269,Q9NPH0,Q9UHD1,Q9NZJ7,Q9H6V9,P14174,Q9BQE5,Q9HB40,Q2TAA5,Q15392,Q8NBX0,P07602,O15382,Q15800,Q86YN1,Q8N8N7,P05067,Q15185,O15118,Q9BV10,P48449,P32929,Q99805,Q16850,P50897,Q06481,P40939,Q96PU8,Q6NUM9,P31751,Q96N66,P61916,Q9UKG9,O75844,Q9Y6X9,O14880,P50542,Q15067,P16278,O00116,Q6UWP7,Q14739,O15254,Q10713 59 +Transmembrane transport 0.4472108682309538 4.501985762428682 6.732149248511732e-06 0.0418871252834709 0.000283478901701 190 P00403,Q99595,Q8TB61,Q8WTV0,Q99797,Q8IXU6,Q6NT16,Q9UHD1,Q9NS69,Q9UHG3,Q9Y584,Q70HW3,Q15043,P21796,O95831,O60830,O43772,Q9HD20,P41440,P05067,Q9UDW1,P27695,O43865,Q99523,Q06481,P31930,Q9UBX3,O75844,P00846,Q9HC07,L0R6Q1,P50542,P45880,Q13423,P08183,Q9Y619,Q9H2D1 37 +Lipid biosynthetic process 0.4926199966716646 4.473647913060855 7.68963217834262e-06 0.0477003068890309 0.0002964310685551 127 P30536,Q9BZF3,Q6P1A2,Q9HCL2,Q8WTV0,Q14849,Q15125,Q8NCC3,P35790,O15269,Q9NPH0,Q9UHD1,P14174,Q15392,Q8NBX0,Q15800,Q99943,Q86YN1,Q15185,P48449,Q05655,Q99805,O95864,Q16850,Q96PU8,Q96N66,Q99570,Q9NZ01,O14735,Q8IVS2,P49327,Q01968,Q06136,O00116,Q6UWP7,Q14739,Q9UBM7,Q10713 38 +Phosphatidylcholine catabolic process 0.9956982131039048 4.235947812319942 2.2758963651225983e-05 0.1346814890731508 0.0005138489525559 2 Q8WTV0 1 +Cellular lipid metabolic process 0.429235144364034 4.20101248587166 2.6572393427626295e-05 0.1554035812181376 0.0005413874560343 191 Q6P1A2,Q8N4Q0,Q9HCL2,Q8WTV0,Q8NHP8,Q9BWD1,Q8NCC3,P07099,P35790,Q14914,O15269,Q9NPH0,Q9UHD1,Q9NZJ7,P14174,Q9HB40,Q2TAA5,Q8NBX0,P07602,Q15800,Q86YN1,Q8N8N7,Q15185,Q9BV10,P48449,Q99805,P50897,Q06481,P40939,Q96PU8,Q6NUM9,P31751,Q96N66,P61916,Q9UKG9,O75844,Q9Y6X9,P50542,Q15067,P16278,O00116,Q6UWP7,O15254,Q10713 44 +Regulation of systemic arterial blood pressure by endothelin 0.9748510919920584 4.142623529277028 3.433553199094774e-05 0.1960678372530988 0.0006234327513605 2 P61586 1 +Regulation of systemic arterial blood pressure by hormone 0.9748510919920584 4.142623529277028 3.433553199094774e-05 0.1960678372530988 0.0006234327513605 2 P61586 1 +Nerve growth factor signaling pathway 0.969225678358703 4.117255205485913 3.834114301293212e-05 0.2162780498102706 0.0006604235907593 2 Q99523 1 +Regulation of appetite 0.9632693580410334 4.090307380687927 4.308018643883749e-05 0.2395337623704339 0.0007112147142993 2 Q9UMX5 1 +Negative regulation of response to food 0.9632693580410334 4.090307380687927 4.308018643883749e-05 0.2395337623704339 0.0007112147142993 2 Q9UMX5 1 +Regulation of response to food 0.9632693580410334 4.090307380687927 4.308018643883749e-05 0.2395337623704339 0.0007112147142993 2 Q9UMX5 1 +Xenobiotic transport 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.3509982072263239 0.0009762257527464 2 P08183 1 +Folate transmembrane transport 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.3509982072263239 0.0009762257527464 2 Q9H2D1 1 +Folic acid transport 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.3509982072263239 0.0009762257527464 2 Q9H2D1 1 +Cellular response to zinc ion 0.9361350099272026 3.966389110098212 7.296970091363875e-05 0.3711184415329213 0.001014869625836 2 P30536 1 +Actin myosin filament sliding 0.9348113831899416 3.960295050907875 7.485721535904766e-05 0.3786186342246764 0.0010343314365698 2 P09493 1 +Negative regulation of protein targeting to mitochondrion 0.924553275976176 3.9129079191657974 9.11913140808629e-05 0.4398991497272298 0.0011756835543569 2 O95429 1 +Cardiolipin acyl chain remodeling 0.9192587690271348 3.888339561082333 0.0001009323549094 0.4735286818555215 0.0012703486095142 2 P40939 1 +Diacylglycerol metabolic process 0.9133024487094664 3.860609348109159 0.0001131046100275 0.5127283748082545 0.0014013506848638 2 Q8NCC3 1 +Diacylglycerol biosynthetic process 0.9133024487094664 3.860609348109159 0.0001131046100275 0.5127283748082545 0.0014013506848638 2 Q8NCC3 1 +Bone maturation 0.911317008603576 3.851344445959914 0.0001174711368299 0.5260675148549637 0.0014377757021718 2 P61586 1 +Fluid transport 0.9109861019192608 3.849799246577552 0.000118214676233 0.5283022681985456 0.0014377757021718 2 O43865 1 +Phosphatidylethanolamine metabolic process 0.9096624751820012 3.843615446800126 0.0001212349278265 0.5372720205747598 0.0014566525543773 2 Q8NCC3 1 +Prostate gland growth 0.9070152217074808 3.8312334078375176 0.0001275024772735 0.5553453716924505 0.0015091354665749 2 P07602 1 +Negative regulation of cyclic nucleotide phosphodiesterase activity 0.9037061548643296 3.8157286941850415 0.0001357816309184 0.5781420542661767 0.0015982000854028 2 Q15043 1 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.8937789543348796 3.769032121293656 0.0001638817988982 0.6471520584890589 0.0018633858923029 2 Q9UIQ6 1 +Regulation of t cell differentiation in thymus 0.8934480476505653 3.767470826480855 0.0001649098050662 0.6494504303557713 0.0018717262875016 2 P00813 1 +Lipid localization 0.5391472469352461 3.749652452597949 0.0001770798176043 0.6755484257396589 0.001950640070526 74 P30536,Q9BZF3,Q6P1A2,Q8WTV0,Q9BUR5,Q14849,Q14108,P35790,Q9H6V9,P14174,Q9BQE5,O43772,P07602,O15118,Q99720,O15260,P61916,Q9UKG9,P08183 19 +Regulation of triglyceride metabolic process 0.8868299139642655 3.73618017714738 0.0001868368172694 0.6950616829466677 0.00204043781884 2 Q8WTV0 1 +Positive regulation of brown fat cell differentiation 0.8792190602250167 3.7000424256753246 0.0002155634266038 0.7459613440398624 0.0022684124826065 2 Q00839 1 +Positive regulation of chemokine c x c motif ligand 2 production 0.8782263401720748 3.6953166143197542 0.0002196129454248 0.7524179354554669 0.0022958221728951 2 P14174 1 +Chemokine c x c motif ligand 2 production 0.8782263401720748 3.6953166143197542 0.0002196129454248 0.7524179354554669 0.0022958221728951 2 P14174 1 +Negative regulation of b cell apoptotic process 0.967680773763832 3.693436833760179 0.000221243485257 0.7549711141960184 0.0023052845775313 3 P14174 1 +Regulation of b cell apoptotic process 0.967680773763832 3.693436833760179 0.000221243485257 0.7549711141960184 0.0023052845775313 3 P14174 1 +Secondary alcohol metabolic process 0.6570782983601655 3.686305021270347 0.0002275336190333 0.7645762595040686 0.0023477332509353 42 P48449,Q6P1A2,Q8WTV0,Q9BQE5,Q14849,Q16850,Q15392,Q15800,Q14739,P61916,P05067,O15118 12 +Small molecule metabolic process 0.3385884153315502 3.68332189909224 0.0002302141474213 0.7685542041961843 0.002363879032326 471 P00403,Q9BZF3,Q8N4Q0,Q6P1A2,Q8WTV0,Q9NUJ1,Q8TB61,Q9BWD1,Q9HCL2,Q14849,Q8NCC3,P07099,P35270,Q969T7,Q15125,Q14914,Q9H773,P49773,Q13126,Q15043,P21796,P14174,Q9BQE5,Q9HB40,P00813,P61586,Q15392,O15382,P09622,Q15800,P55263,P41440,O60725,Q8N8N7,P05067,Q15185,O15118,P48449,P09874,O43865,Q16850,P11182,P50897,Q06481,P40939,Q6NUM9,Q96DE0,P61916,P43490,Q9UBX3,Q9UKG9,O75844,Q9Y6X9,P00846,Q16775,O14880,P50542,Q15067,P30837,Q9UMR5,P16278,Q6PJG6,O00116,Q14739,Q9Y619,Q9H2D1,O15254,Q10713 68 +Monocarboxylic acid metabolic process 0.4296197397800733 3.655738359862737 0.0002564428037381 0.804101672351605 0.0025289495361961 151 Q9BZF3,Q8N4Q0,Q9NUJ1,Q9BWD1,Q8NCC3,P07099,Q14914,P21796,P14174,Q9HB40,P09622,Q15800,Q8N8N7,Q15185,P05067,O15118,Q06481,P40939,Q9UKG9,Q9Y6X9,Q16775,P50542,Q15067,O15254 24 +Positive regulation of monocyte chemotaxis 0.8666446062210456 3.639972327464488 0.0002726673428605 0.8233014225732884 0.0026378594082524 2 P09429 1 +Protein containing complex remodeling 0.8653209794837895 3.633622497992504 0.0002794696695487 0.830780311820754 0.0026824553115302 2 Q8WTV0 1 +Mitochondrial transport 0.4891574086532038 3.622518410146036 0.0002917486895803 0.8434884118990335 0.0027350363878655 83 P30536,Q99595,Q14849,Q99797,O60220,Q9Y584,Q9NS69,P55786,O95831,O60830,Q5JRX3,O43772,Q9Y5J9,O95429,Q9UBX3,P00846,P49257,P45880,Q9BZL1,Q9Y5L4,Q10713 21 +Behavioral response to cocaine 0.8603573792190614 3.609765016091415 0.0003064745146375 0.8574768127351355 0.0028231188623709 2 Q00535 1 +Dna methylation on cytosine 0.8603573792190632 3.609765016091415 0.0003064745146375 0.8574768127351355 0.0028231188623709 2 P26358 1 +Regulation of vasoconstriction 0.9467080598484788 3.601678135214995 0.0003161696639675 0.8659968717806991 0.0028914739340684 3 P61586 1 +Positive regulation of heart rate 0.9445197145792028 3.5920424144779397 0.00032809643204 0.8757827338114137 0.0029833775708817 3 P00813 1 +Protein targeting 0.4687595090622226 3.566902121308122 0.0003612263250074 0.8993764850128247 0.00325072443564 105 P30536,Q99595,Q14108,Q99797,O43681,O60220,P43307,Q9UHD1,Q9Y584,Q9NS69,P55786,Q00535,O95831,O60830,O00170,Q5JRX3,O60725,P27695,Q99523,Q9Y5J9,P31751,O95429,P49257,P50542,P46379,Q9BZL1,Q9Y5L4,Q10713 28 +Lipid translocation 0.8514228987425579 3.566638754101783 0.00036158939207 0.8996085053344721 0.00325072443564 2 P08183 1 +Cleavage furrow formation 0.8421575115817381 3.521664344539675 0.0004288467574085 0.9345412183205376 0.0036538203620489 2 P61586 1 +Alcohol metabolic process 0.4792950177650262 3.513208043309133 0.0004427306726395 0.9400724688199692 0.0037519948737293 80 P48449,Q6P1A2,Q8WTV0,Q9BQE5,Q16850,Q14849,Q15392,Q15125,P35270,P30837,Q15800,Q6NUM9,Q14739,P61916,P05067,Q10713,O15118 17 +B cell homeostasis 0.9265651423374314 3.512539302331628 0.0004438463535991 0.9404961149421412 0.0037564413095557 3 P14174 1 +Protein localization to mitochondrion 0.551235253734114 3.507849162451547 0.0004517451068899 0.9434109989734522 0.0037879840361378 57 P30536,O95831,Q9NS69,Q99595,O60830,P49257,Q9Y6C9,Q5JRX3,Q99797,O95429,O60220,Q9Y5J9,Q9BZL1,Q9Y5L4,Q9Y584,P55786,Q10713 17 +Steroid biosynthetic process 0.6344120098448139 3.505504384836005 0.0004557429943266 0.944831478359084 0.0037968407232095 42 P30536,P48449,Q9BZF3,Q6P1A2,Q14849,Q16850,Q15392,Q15800,Q14739 9 +Phospholipid homeostasis 0.8358702845797508 3.490998889689746 0.0004812182531734 0.953082258243544 0.0039619471725008 2 Q9HCL2 1 +Negative regulation of blood pressure 0.9150308856137352 3.461040915515513 0.0005380910231784 0.9673211447233598 0.0043020208092105 3 P42785 1 +Phosphagen metabolic process 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.9696268207573628 0.0043665437938719 2 P12532 1 +Organic hydroxy compound metabolic process 0.4576395465097214 3.453388528603375 0.0005535910452203 0.9703886925623758 0.0043818489208225 107 Q9BZF3,Q6P1A2,Q8WTV0,Q14849,Q15125,P35270,Q14914,Q9BQE5,Q15392,Q15800,P05067,O15118,P48449,Q16850,Q6NUM9,P61916,Q9Y4G8,Q16775,P30837,Q14739,Q10713 21 +Positive regulation of gastrulation 0.826604897418929 3.44558845716963 0.0005698174366297 0.9732919935173968 0.0044768351387129 2 O95747 1 +Protein targeting to mitochondrion 0.60479889594807 3.4389487079368006 0.0005839778680432 0.9755920784388548 0.0045767735256259 46 P30536,O95831,Q9NS69,Q99595,O60830,P49257,Q5JRX3,Q99797,O95429,O60220,Q9Y5J9,Q9BZL1,Q9Y5L4,Q9Y584,P55786,Q10713 16 +Vesicle tethering 0.9087707963719032 3.432949661601918 0.000597052936452 0.9775396059183512 0.0046401054960337 3 Q9BZH6 1 +Tetrapyrrole catabolic process 0.9087127016716274 3.4326885017066986 0.0005976282834758 0.977621640376018 0.0046401054960337 3 P30519 1 +Regulation of neurotrophin trk receptor signaling pathway 0.8239576439444115 3.432565674288256 0.0005978990562069 0.9776601441109344 0.0046401054960337 2 Q7L576 1 +Positive regulation of neurotrophin trk receptor signaling pathway 0.8239576439444115 3.432565674288256 0.0005978990562069 0.9776601441109344 0.0046401054960337 2 Q7L576 1 +Glycolipid transport 0.9073154584574572 3.4264047088042946 0.0006116283269765 0.9795280369852964 0.0047064281431757 3 P07602,P61916 2 +Steroid metabolic process 0.5290963330078374 3.422474999020287 0.0006205380419255 0.9806558270687132 0.0047612880804733 65 P30536,P48449,Q9BZF3,Q6P1A2,Q8WTV0,Q9BQE5,Q14849,Q16850,Q15392,Q15800,Q14739,P61916,P05067,O15118 14 +Positive regulation of ruffle assembly 0.904998344918898 3.415972971624505 0.0006355455477335 0.9824168056113542 0.0048261977316544 3 Q8NCA5,Q7L576 2 +Intraciliary transport involved in cilium assembly 0.8193249503639987 3.409723686092134 0.0006502872672546 0.9839904577781182 0.0048865625801067 2 A0AVF1 1 +Mammalian oogenesis stage 0.8156849768365353 3.391729647935874 0.0006945293312101 0.9879170766230686 0.0051812540248495 2 Q96MU7 1 +Protein retention in golgi apparatus 0.8136995367306432 3.381897294249978 0.0007198705355988 0.9897157820618276 0.005350844545638 2 Q9H4A6 1 +Negative regulation of vascular associated smooth muscle cell migration 0.8966476413303013 3.3782630415089727 0.0007294526876746 0.99032386876458 0.0053662051884955 3 P61586 1 +Alditol phosphate metabolic process 0.8958053188410242 3.374449280372555 0.0007396354430828 0.9909307190199886 0.0054238261718705 3 Q9NPH0 1 +Leukotriene metabolic process 0.8957880698720718 3.3743711634195948 0.0007398453887683 0.9909428220786198 0.0054238261718705 3 Q14914 1 +Meiotic spindle assembly 0.8103904698874944 3.3654825980080743 0.0007640988683124 0.992237639622895 0.0055695096410478 2 O14965 1 +Regulation of protein glycosylation 0.8103904698874945 3.3654825980080743 0.0007640988683124 0.992237639622895 0.0055695096410478 2 Q9UHD1 1 +Positive regulation of protein glycosylation 0.8103904698874945 3.3654825980080743 0.0007640988683124 0.992237639622895 0.0055695096410478 2 Q9UHD1 1 +Positive regulation of smooth muscle contraction 0.8933328079105909 3.36324390414229 0.0007703227180162 0.9925389414696278 0.0056084435231515 3 P00813 1 +Metanephric glomerulus development 0.8074123097286583 3.350679937133865 0.000806134170896 0.9940588652672518 0.0058027053116819 2 O95747 1 +L serine catabolic process 0.806750496360028 3.3473866584349574 0.0008157733905993 0.994412211776622 0.0058342454142311 2 P34896 1 +Regulation of blood pressure 0.836729932085147 3.339668935900417 0.0008387831727325 0.9951730621688518 0.0059434847780247 16 Q9HB40,P61586,Q9UIQ6,P42892,Q9NZ08,P42785,P09493 7 +Positive regulation of smad protein signal transduction 0.8034414295168804 3.330899482285254 0.0008656585491322 0.9959316126829028 0.0060888381387593 2 P09874 1 +Neuron death in response to hydrogen peroxide 0.8027796161482479 3.327597882049589 0.0008759820959336 0.9961902139567894 0.0061522013279052 2 P63244 1 +Regulation of system process 0.5307126723878429 3.290723795361522 0.0009992997870398 0.9982614869728812 0.0069113704531285 56 Q9UQB8,P09874,Q6P1A2,Q13555,P00813,P61586,P42892,P05067,P09493,O75844 10 +Positive regulation of cell adhesion molecule production 0.8765161882666601 3.2866062086423886 0.0010140252674797 0.9984169700533224 0.0069903954447952 3 Q5KU26 1 +Response to arsenite ion 0.7941760423560591 3.284550042423352 0.0010214535674952 0.9984900473047126 0.0070263624188311 2 Q9H2U1 1 +Nucleotide excision repair dna gap filling 0.7925215089344826 3.276244435009944 0.0010519747160597 0.9987565564601352 0.0071665072832539 2 P28340 1 +Positive regulation of blood pressure 0.9553219263128756 3.266297924169283 0.0010896354560192 0.999021508989636 0.0073443509633705 4 P61586 1 +Positive regulation of calcium mediated signaling 0.9491305010631016 3.2401224942876428 0.0011947836088994 0.9994988398538398 0.0079269776807567 4 P49773 1 +Regulation of toll like receptor 4 signaling pathway 0.865035313594088 3.2338539532791284 0.0012213189294791 0.9995767075925236 0.0080505125398996 3 P41440 1 +Toll like receptor 4 signaling pathway 0.865035313594088 3.2338539532791284 0.0012213189294791 0.9995767075925236 0.0080505125398996 3 P41440 1 +Hydrogen sulfide metabolic process 0.783917935142293 3.232912798280102 0.0012253496002734 0.99958742711199 0.0080541076104838 2 P32929 1 +Hydrogen sulfide biosynthetic process 0.783917935142293 3.232912798280102 0.0012253496002734 0.99958742711199 0.0080541076104838 2 P32929 1 +Lung alveolus development 0.8629428372034748 3.224201332525644 0.0012632455190602 0.9996758370421778 0.0082775139372646 3 P00813 1 +Fatty acid metabolic process 0.4566972735076135 3.200403544411948 0.0013723529467881 0.9998381217593064 0.0089097807250108 91 Q8N4Q0,Q9HCL2,Q9BWD1,Q8NCC3,P07099,Q14914,P14174,Q15800,Q8N8N7,Q15185,Q96PU8,Q06481,P40939,P31751,Q9UKG9,Q9Y6X9,P50542,Q15067,O15254 19 +Response to aldosterone 0.8565560473709264 3.1946657367204736 0.0013999287830934 0.9998641801809404 0.0090378845117741 3 O95831 1 +Maintenance of protein location in mitochondrion 0.8555766495056376 3.1901267350188096 0.0014221041495017 0.9998820591344376 0.0091579472889898 3 P30536 1 +Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway 0.7749834546657868 3.1876595079781587 0.0014342932414126 0.9998908635771931 0.0092084523660795 2 Q99497 1 +Detection of external biotic stimulus 0.8529469231433375 3.1779263824312864 0.0014833240855023 0.9999201217698004 0.0093699567868921 3 Q8WTV0 1 +Positive regulation of membrane depolarization 0.8528304241178521 3.1773854602633973 0.0014860937760059 0.999921517707679 0.0093699567868921 3 P30536 1 +Positive regulation of mitochondrial depolarization 0.8528304241178521 3.1773854602633973 0.0014860937760059 0.999921517707679 0.0093699567868921 3 P30536 1 +Sulfur amino acid catabolic process 0.7726671078755818 3.1758843947143425 0.0014938046787682 0.9999252768915968 0.0093820380812757 2 P25325 1 +Positive regulation of t cell receptor signaling pathway 0.852170359031313 3.1743199802771827 0.0015018802167845 0.9999290209844768 0.0094048774954508 3 P00813 1 +Positive regulation of antigen receptor mediated signaling pathway 0.852170359031313 3.1743199802771827 0.0015018802167845 0.9999290209844768 0.0094048774954508 3 P00813 1 +Organic hydroxy compound biosynthetic process 0.5686794496147003 3.1724427700296265 0.0015116234921985 0.99993328948628 0.0094194891337393 47 P48449,Q9BZF3,Q6P1A2,Q16850,Q15392,Q15125,P35270,Q15800,Q14739,Q9Y4G8 10 +Neuropeptide signaling pathway 0.8494075894191702 3.161476163376571 0.0015697166527814 0.9999539119967156 0.0096304237886864 3 Q99523 1 +Response to l glutamate 0.9305043502748273 3.160852628408504 0.001573080661962 0.9999548884915884 0.0096417557255841 4 Q9UQB8 1 +C21 steroid hormone biosynthetic process 0.8485175118426064 3.1573338333919176 0.0015921895227786 0.9999600555817152 0.0097494764997889 3 P30536 1 +Protein o linked glycosylation via threonine 0.7683653209794876 3.1539692877358627 0.0016106603521941 0.9999644869567904 0.0098341567709375 2 Q10472 1 +Epithelial cell differentiation involved in prostate gland development 0.8437516693343114 3.1351170332519573 0.0017178556309058 0.9999820528550472 0.0103103780831328 3 P07602 1 +Modified amino acid transport 0.9187048747362648 3.1102236339771 0.0018694574594217 0.9999931645768096 0.0110225154100973 4 Q9H2D1,O43772 2 +Circulatory system process 0.4990080955448049 3.100601399392252 0.0019312807612041 0.9999953891081071 0.0113240041680939 65 Q9HB40,P00813,P61586,Q9UIQ6,P42892,P42785,P09601,Q9NZ08,P08183,P09493,O75844 11 +Pyrimidine deoxyribonucleoside metabolic process 0.7577763070814063 3.0997620140353748 0.0019367619143058 0.9999955472780206 0.0113438638728136 2 P04183 1 +Regulation of membrane lipid distribution 0.8361469712015885 3.0995364483478527 0.0019382372822334 0.9999955889182802 0.0113438638728136 3 Q05655,P08183 2 +Negative regulation of nitric oxide metabolic process 0.8359318951015744 3.0985278237623226 0.00194484707173 0.9999957707426982 0.0113691204058076 3 P30536 1 +Neutrophil differentiation 0.8358902271449745 3.098332402103548 0.0019461301135177 0.9999958051587822 0.0113691204058076 3 Q14739 1 +Fatty acid homeostasis 0.8325482328481102 3.082642772367351 0.0020517128455521 0.9999978586691832 0.0118015265577643 3 Q9HCL2 1 +Positive regulation of actin cytoskeleton reorganization 0.832015146810295 3.080137214934554 0.0020690524860702 0.9999980825633566 0.0118865701656827 3 Q9UQB8 1 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.8319788534898873 3.0799666038322933 0.0020702380700772 0.9999980969877754 0.0118865701656827 3 P14174 1 +Pons development 0.8318979209340446 3.0795861350901763 0.0020728842087691 0.9999981287919448 0.0118910216885711 3 O14949 1 +Cellular response to nitrosative stress 0.7531436135009959 3.075928039693927 0.0020984848380973 0.9999984103298306 0.0120161888567089 2 Q99497 1 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.9097056524816812 3.0713920535886063 0.0021306318862079 0.9999987046681202 0.012178323982678 4 P61586,P09493 2 +Regulation of isomerase activity 0.8298462096781812 3.069934796639298 0.0021410550811298 0.9999987878746444 0.0121940377201265 3 Q00839 1 +Regulation of dna topoisomerase atp hydrolyzing activity 0.8298462096781812 3.069934796639298 0.0021410550811298 0.9999987878746444 0.0121940377201265 3 Q00839 1 +Acute inflammatory response 0.9084473326013592 3.0659472781081294 0.0021698157132159 0.999998990779891 0.012324708376408 4 P42785 1 +Vacuolar proton transporting v type atpase complex assembly 0.8230361514839266 3.037815277382069 0.0023829998179987 0.9999997404775008 0.013147870523611 3 Q8N511 1 +Proton transporting v type atpase complex assembly 0.8230361514839266 3.037815277382069 0.0023829998179987 0.9999997404775008 0.013147870523611 3 Q8N511 1 +Cellular response to mineralocorticoid stimulus 0.8213147274904815 3.029675518734132 0.0024481660573068 0.9999998286610368 0.0133317638368485 3 O95831 1 +Organic cation transport 0.8989179190871933 3.0245919982327067 0.0024896873907591 0.999999868490242 0.0133317638368485 4 Q70HW3 1 +Purine nucleoside triphosphate catabolic process 0.898600999088127 3.0232129487303325 0.0025010617994762 0.9999998776844164 0.0133473961355762 4 P00813 1 +Establishment of planar polarity involved in neural tube closure 0.7402382528127103 3.0091494053468555 0.0026198024944532 0.9999999426053418 0.0138863235660465 2 O95487 1 +Animal organ maturation 0.8169350302128641 3.0089282853642354 0.0026217099243637 0.9999999432987784 0.0138863235660465 3 P61586 1 +Lipoprotein catabolic process 0.8947378441265423 3.0063835612696335 0.0026437528397835 0.9999999507297154 0.0139681571485157 4 Q9NUJ1 1 +Protein depalmitoylation 0.8947378441265423 3.0063835612696335 0.0026437528397835 0.9999999507297154 0.0139681571485157 4 Q9NUJ1 1 +Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.8163230540612223 3.0060249355405846 0.0026468729115576 0.999999951699719 0.0139730267656647 3 P14174 1 +Protein processing involved in protein targeting to mitochondrion 0.8156789566175484 3.002968045172738 0.0026736050265423 0.9999999592655224 0.0140549876080311 3 Q10713 1 +Regulation of modification of postsynaptic structure 0.8919117403624011 2.9940494306777308 0.0027530133898059 0.9999999754433644 0.0140549876080311 4 Q9UQB8,P61586 2 +Gmp salvage 0.8909080642178779 2.9896644345353423 0.0027928407887105 0.9999999809487016 0.0140883302008288 4 P00813 1 +Sterol metabolic process 0.5876157571432229 2.9864206409712297 0.0028226408901239 0.9999999842444528 0.0142058800061458 38 P48449,Q6P1A2,Q8WTV0,Q9BQE5,Q14849,Q16850,Q15392,Q15800,Q14739,P61916,P05067,O15118 12 +Response to progesterone 0.8121513927082791 2.986205252276837 0.0028246298671152 0.9999999844429366 0.0142058800061458 3 P30536 1 +Positive regulation of amyloid precursor protein biosynthetic process 0.7346128391793578 2.979862298510278 0.002883779859891 0.9999999893295176 0.0144438966032054 2 Q92542 1 +Modulation of excitatory postsynaptic potential 0.8879160641050926 2.9765782630201634 0.0029148467442703 0.9999999912465668 0.0145765270704817 4 Q9UQB8 1 +Serine family amino acid catabolic process 0.8070175438596501 2.9617459644853104 0.0030590005575072 0.9999999965080532 0.0151543316785006 3 P34896,P23378 2 +Purine deoxyribonucleoside triphosphate metabolic process 0.8836163928146988 2.9577350627913224 0.0030990835954665 0.9999999972955332 0.0153051867387608 4 P00813,Q96DE0 2 +Negative regulation of sodium ion transmembrane transport 0.8051151276951067 2.9526630602041912 0.0031504563105251 0.9999999980509224 0.015510689627961 3 Q13557 1 +Positive regulation of b cell proliferation 0.8777468804442615 2.931940125191493 0.0033685168348014 0.9999999995147876 0.0163812494276954 4 P00813,P14174 2 +Corpus callosum development 0.799868811887882 2.927561041924759 0.0034163199183752 0.9999999996422924 0.016588334149116 3 Q00535 1 +Malonyl coa metabolic process 0.7243547319655896 2.926174356409902 0.0034315855445603 0.9999999996754776 0.0166411251618571 2 O00763 1 +Negative regulation of establishment of protein localization to mitochondrion 0.7992382703210437 2.924538745560132 0.0034496713180935 0.9999999997108332 0.0166865379739748 3 O95429 1 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.875578057170467 2.9223876340226624 0.0034735893243 0.9999999997517458 0.016776697374811 4 P30536 1 +Positive regulation of inflammatory response to antigenic stimulus 0.7233620119126446 2.920959293866666 0.0034895541784742 0.9999999997757804 0.0168281889353767 2 Q99497 1 +Ion transport 0.3669173834397836 2.913657469922772 0.0035722162348392 0.9999999998676612 0.0170644411338152 184 P30536,P00403,Q8TB61,O43681,Q9UHD1,Q9NZJ7,Q9UHG3,Q15043,Q70HW3,P21796,P14174,Q13555,P61586,O43772,P07602,Q9HD20,P41440,P05067,Q9UDW1,P27695,O43865,P31930,Q9UBX3,O75844,P00846,Q9HC07,P45880,Q13423,P08183,Q9Y619,Q9H2D1 31 +Positive regulation of t cell migration 0.8734573459994202 2.9130360113159504 0.0035793332147029 0.9999999998735348 0.0170644411338152 4 P61586,P05067 2 +Positive regulation of lymphocyte migration 0.8734573459994202 2.9130360113159504 0.0035793332147029 0.9999999998735348 0.0170644411338152 4 P61586,P05067 2 +Sterol biosynthetic process 0.6685276371333597 2.91204563087059 0.0035907017683682 0.9999999998823812 0.017069933014023 23 P48449,Q6P1A2,Q16850,Q15392,Q15800,Q14739 6 +Glycerolipid biosynthetic process 0.5746029040610214 2.910240889325721 0.0036115028459762 0.999999999896997 0.0170921162241436 39 Q01968,Q6P1A2,Q9HCL2,Q8WTV0,Q8NCC3,P35790,Q99943,Q9NPH0,Q96N66,Q6UWP7,Q99570,Q10713,O14735 13 +Regulation of gastrulation 0.7957679063841434 2.907884081657374 0.0036388319277509 0.999999999913476 0.017170316059974 3 O95747 1 +Lysosomal lumen acidification 0.86986754966887 2.8971812832547963 0.0037653210883021 0.9999999999613916 0.0176572320139442 4 Q8N511,O75503,P50897 3 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9999999999651418 0.0176982159881644 3 P10321 1 +Response to nitrogen compound 0.3290725719739361 2.872427090711706 0.0040733205802094 0.9999999999945908 0.0188154255870722 224 P30536,Q9UQB8,P26358,Q9H2U1,Q86X55,Q14103,Q92542,Q00535,Q15043,P49815,O95831,P08670,Q9Y4I1,P61586,Q5KU26,Q7L576,P49721,P41440,P05067,O15118,P27695,P09874,O43865,Q99523,P78527,Q06481,P40939,P31930,O60828,P43490,Q9NUD5,Q9Y4G8,P46379,Q8IWV8 34 +Histone arginine methylation 0.7864528423282287 2.863006910933997 0.0041964141025503 0.9999999999975344 0.019285906027339 3 Q86X55 1 +Vascular associated smooth muscle cell migration 0.8614428717652984 2.8598491565103643 0.0042384255805285 0.9999999999981142 0.0194157471953472 4 P61586 1 +Anatomical structure maturation 0.6230711133824036 2.859507453627067 0.0042429944704747 0.9999999999981684 0.0194157471953472 28 Q9Y2W6,P61586,P04818,Q15125,P09622,Q08J23,O14965,Q9NZJ7,P05067 9 +Motor neuron apoptotic process 0.7114493712773042 2.858108496988924 0.0042617464569416 0.9999999999983752 0.0194875255254109 2 P49327 1 +Damp metabolic process 0.7834238108451912 2.848359322436437 0.0043945276959389 0.9999999999993038 0.0199940000253314 3 P00813 1 +Purine deoxyribonucleoside monophosphate metabolic process 0.7834238108451912 2.848359322436437 0.0043945276959389 0.9999999999993038 0.0199940000253314 3 P00813 1 +Neuron fate commitment 0.7828533598146236 2.845597761498004 0.0044328150190511 0.9999999999994548 0.0201537712883326 3 Q9UPW6,Q96KQ7 2 +Regulation of long chain fatty acid import across plasma membrane 0.7078093977498395 2.838804068687347 0.0045282952453105 0.9999999999997036 0.0205437862806521 2 P31751 1 +Long chain fatty acid import across plasma membrane 0.7078093977498395 2.838804068687347 0.0045282952453105 0.9999999999997036 0.0205437862806521 2 P31751 1 +Negative regulation of t cell apoptotic process 0.7804851077785838 2.834122795311498 0.0045951670966148 0.9999999999998066 0.0207674157089708 3 P00813 1 +Hypothalamus development 0.8546387688495526 2.8295710374421112 0.0046610451271613 0.999999999999873 0.0210110658356295 4 P27695,O75569 2 +Positive regulation of long term synaptic potentiation 0.779400558774132 2.8288622864325883 0.0046713795424251 0.9999999999998812 0.0210427274072673 3 P05067 1 +Antigen processing and presentation of exogenous peptide antigen 0.8536141753347862 2.8250017251019837 0.0047280361478212 0.9999999999999172 0.0211778701589512 4 P04439,Q9UIQ6 2 +Coronary vasculature morphogenesis 0.7035076108537439 2.815928975576948 0.0048636417579503 0.9999999999999653 0.0216328250619543 2 O95487 1 +Pigment metabolic process 0.6169417916705563 2.79995685344519 0.0051109437510481 0.9999999999999928 0.0224966471479653 27 P30536,P00813,P22830,P30519,Q9Y4G8 5 +Cell projection organization 0.3260841326786967 2.78551512491732 0.0053442746679883 0.9999999999999984 0.0233619049447964 235 P30536,Q9UQB8,O14976,A6NIH7,P63167,Q9H2U1,P43034,Q14108,Q86X55,Q9NR77,Q8WUW1,Q14141,Q96F07,O14965,Q99538,P35579,Q9NT62,Q00535,P07737,P21333,Q15154,O94915,P08670,Q13555,P61586,Q7L576,P84095,Q66K74,P41440,P05067,P09493,P27695,Q05655,O43805,Q15428,Q9BZH6,Q8NCA5,Q9Y6A4,O95684,P42892,Q06481,A0AVT1,O60828,O95429,Q9P258,Q9Y4G8,Q01968,O95487,Q92766,P09429,A0AVF1,Q99873,Q9H4A6,P10586 54 +Anion transport 0.4793610188914063 2.783481765130769 0.0053778885382369 0.9999999999999988 0.023460438949234 58 P30536,P14174,Q8TB61,O43865,P45880,P07602,O43681,P08183,P41440,Q9Y619,Q9H2D1,Q9UHG3,Q9UBX3,Q15043,P21796 15 +Response to bacterium 0.4803211281867461 2.773396583669667 0.0055474469441949 0.9999999999999996 0.0240844076347699 56 P30536,Q9UQB8,P14174,P08670,O43823,Q8WTV0,P61586,P62888,Q9NZ08 9 +Glucosylceramide metabolic process 0.6949040370615537 2.769980218509982 0.0056059697222385 0.9999999999999996 0.0243052820972363 2 Q05655 1 +Regulation of mitochondrial atp synthesis coupled electron transport 0.6939113170086085 2.764661326253227 0.0056981922747878 0.9999999999999998 0.0246378980262255 2 P06493 1 +Glutamate receptor signaling pathway 0.7657028727300192 2.7621234751428947 0.0057426756100507 1.0 0.0248133556611028 3 P05067 1 +Mitochondrion distribution 0.8391265406470597 2.7601133833069285 0.0057781303858046 1.0 0.0249495901713141 4 P27695,O75153 2 +Protein transmembrane transport 0.6245279636759224 2.753577473374786 0.0058947816567083 1.0 0.0253499541339905 25 O95831,Q9NS69,Q99595,O60830,P50542,P31751,Q9Y584 7 +Keratan sulfate metabolic process 0.7631602401045959 2.7496737268975986 0.0059654631026289 1.0 0.0256365675999387 3 P16278 1 +Macromolecule depalmitoylation 0.9038447912352336 2.745692796216572 0.0060383276520195 1.0 0.025932169294754 5 Q9NUJ1,Q9UMR5 2 +Negative regulation of autophagy of mitochondrion 0.8339705443640134 2.7368940042965946 0.006202227345931 1.0 0.0265642567457799 4 P30536 1 +Pyrimidine nucleoside metabolic process 0.7580271433300083 2.724481140680332 0.0064402608390556 1.0 0.0272350618050827 3 P04183,P84090 2 +Deoxyribonucleoside triphosphate biosynthetic process 0.7580271433300073 2.7244811406803207 0.0064402608390559 1.0 0.0272350618050827 3 P04818,P55263 2 +Dttp metabolic process 0.7580271433300078 2.7244811406803207 0.0064402608390559 1.0 0.0272350618050827 3 Q9H773,P04818 2 +Manganese ion transport 0.8309687646757185 2.7233451619220435 0.006462450078575 1.0 0.0272925798667262 4 Q9HD20,Q15043 2 +Manganese ion transmembrane transport 0.8309687646757185 2.7233451619220435 0.006462450078575 1.0 0.0272925798667262 4 Q9HD20,Q15043 2 +Fatty acid elongation 0.6859695565850484 2.7219820433044415 0.0064891668377276 1.0 0.0273872140907016 2 Q9NZ01 1 +Regulation of response to external stimulus 0.3888225961290106 2.720426711802307 0.0065197722433374 1.0 0.0273888061565605 120 P60900,Q6P1A2,Q9UMX5,Q99538,P14174,Q96KB5,P00813,Q14166,P19474,P05067,P04439,P78527,Q9NZ08,Q06481,Q15366,O60828,Q9NUD5,O75844,O75531,P80303,P09429,P53634,O95747,P10586 24 +Modification of postsynaptic actin cytoskeleton 0.8977836183252013 2.7202115132165368 0.0065240170737936 1.0 0.0273888061565605 5 Q9UQB8,Q7L576,P61586 3 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.756702223830817 2.7179657858620496 0.0065684629945024 1.0 0.0275390176735207 3 O75844 1 +Phosphatidylinositol 3 phosphate biosynthetic process 0.7557100297914481 2.713083173575104 0.0066660372847615 1.0 0.0278788193486699 3 Q99570,Q01968 2 +Phagocytosis recognition 0.7556554731265072 2.7128146130613557 0.0066714418233679 1.0 0.0278788193486699 3 Q8WTV0 1 +Alcohol biosynthetic process 0.5684367157613844 2.7100703356929645 0.0067268941437959 1.0 0.0280736304517181 33 P48449,Q6P1A2,Q16850,Q15392,Q15125,P35270,Q15800,Q14739 8 +Histone h3 k9 demethylation 0.681005956320323 2.6951913337805955 0.0070348222438239 1.0 0.0290355248428276 2 Q7LBC6 1 +Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization 0.680344142951693 2.6916124621535493 0.0071107519455511 1.0 0.02919634325964 2 Q709C8 1 +Phosphatidylcholine acyl chain remodeling 0.7494207216153433 2.682064441474658 0.0073169363613678 1.0 0.0296976037757689 3 Q6P1A2,Q96N66 2 +Regulation of relaxation of muscle 0.6783587028458031 2.680866259816316 0.007343185710825 1.0 0.0297661277920943 2 Q13557 1 +Sequestering of metal ion 0.6783587028458028 2.680866259816316 0.007343185710825 1.0 0.0297661277920943 2 O14617 1 +Glycosaminoglycan catabolic process 0.8199244523242277 2.673300139022468 0.0075109016816385 1.0 0.0302914283556439 4 P15586,P16278 2 +Aminoglycan catabolic process 0.8199244523242277 2.673300139022468 0.0075109016816385 1.0 0.0302914283556439 4 P15586,P16278 2 +Purine nucleotide salvage 0.886036955275465 2.6706012823497987 0.0075715525357651 1.0 0.0304383009122452 5 P00813 1 +Purine ribonucleotide salvage 0.886036955275465 2.6706012823497987 0.0075715525357651 1.0 0.0304383009122452 5 P00813 1 +Amp salvage 0.886036955275465 2.6706012823497987 0.0075715525357651 1.0 0.0304383009122452 5 P00813 1 +Nucleotide salvage 0.886036955275465 2.6706012823497987 0.0075715525357651 1.0 0.0304383009122452 5 P00813 1 +Positive regulation of gluconeogenesis 0.6737260092653928 2.6557357530759456 0.0079135597416735 1.0 0.0315945890188925 2 P61964 1 +Estrogen biosynthetic process 0.6733951025810776 2.6539377096196164 0.0079558511863051 1.0 0.0317036928778404 2 Q53GQ0 1 +Fatty acid beta oxidation using acyl coa oxidase 0.8819903646430891 2.653441460333461 0.0079675589583214 1.0 0.0317304540971749 5 O15254,Q9UKG9 2 +Positive regulation of lyase activity 0.6720714758438178 2.6467415197355484 0.0081271447089372 1.0 0.0322447763857711 2 Q99497 1 +Regulation of mitochondrial electron transport nadh to ubiquinone 0.6720714758438178 2.6467415197355484 0.0081271447089372 1.0 0.0322447763857711 2 Q99497 1 +Phosphatidylcholine metabolic process 0.7866404607604986 2.638855152027717 0.0083186515582622 1.0 0.032820204409879 11 Q8WTV0,P35790,Q6P1A2,Q8NCC3 4 +Establishment of planar polarity of embryonic epithelium 0.7404832836808879 2.637779693933846 0.0083450776410298 1.0 0.0328836413430786 3 P43034,O95487 2 +Positive regulation of ion transport 0.556499724191005 2.63493533605592 0.0084153313285981 1.0 0.0330864025852595 34 P30536,P27695,O43865,P14174,P08183,Q9UHD1 6 +Ureter development 0.7394902350215199 2.6328442201710196 0.0084673173657496 1.0 0.0332255740317917 3 Q9BRK4,O95747 2 +Ph reduction 0.7849816141605578 2.6306214852220617 0.0085228902083172 1.0 0.0332953227806171 11 Q8N511,Q9Y487,P50897,O75503,Q93050 5 +Establishment of protein localization to organelle 0.3555788954861477 2.627129268189887 0.0086108615276048 1.0 0.0335488150397937 179 P30536,Q99595,Q14108,Q99797,O43681,O60220,Q5SRE5,Q15388,Q9UHD1,Q9Y584,Q9NS69,P55786,P55735,P49815,O95831,O60830,O00170,Q9UI26,Q5JRX3,P62826,P49368,Q9UFC0,Q92973,Q05655,Q99523,O14617,Q06481,Q9Y5J9,P13473,O95429,P49257,P50542,P46379,P52789,Q9BZL1,P49458,Q9Y5L4,Q10713 38 +C21 steroid hormone metabolic process 0.8097664426359809 2.626998544275846 0.008614170255655 1.0 0.0335488150397937 4 P30536 1 +Negative regulation of muscle cell apoptotic process 0.8095072962100437 2.6258138868842225 0.0086442067487348 1.0 0.0336040232996691 4 P26358 1 +Cellular hormone metabolic process 0.681505392958327 2.621359752312136 0.0087579788882241 1.0 0.0340254974410469 18 P30536,Q9HB40,Q6NUM9,P42892 4 +Inositol phosphate catabolic process 0.736190814066434 2.616424498544239 0.0088856012983344 1.0 0.0344581341380195 3 Q10713 1 +Negative regulation of ire1 mediated unfolded protein response 0.6657842488418324 2.612471697182249 0.0089890134866164 1.0 0.0347954748604956 2 Q96HY6 1 +Transepithelial transport 0.8063910019126073 2.611554704803129 0.0090131566567968 1.0 0.0348676955024957 4 O43865 1 +Cellular response to biotic stimulus 0.5535663212421057 2.611292009460805 0.0090200837318614 1.0 0.0348732677613817 34 P30536,P14174,O43823,Q8WTV0,P61586,O75844 6 +Phosphatidylinositol acyl chain remodeling 0.7350868579337737 2.610923212632396 0.0090298166434914 1.0 0.0348896745203839 3 Q6UWP7 1 +Cardiac muscle cell proliferation 0.6651224354732024 2.608855880864716 0.0090845493804785 1.0 0.0350060167698423 2 P06493 1 +Positive regulation of rna export from nucleus 0.7346501702422303 2.6087460653342487 0.0090874650204908 1.0 0.0350060167698423 3 Q08211 1 +Positive regulation of nucleobase containing compound transport 0.7346501702422303 2.6087460653342487 0.0090874650204908 1.0 0.0350060167698423 3 Q08211 1 +Regulation of long term synaptic potentiation 0.8049782564152335 2.605082262286954 0.0091852203902798 1.0 0.0353611513026156 4 Q92542,P05067 2 +Regulation of ion transport 0.4494572719120225 2.6028401440436055 0.009245505143725 1.0 0.0354703006166214 68 P30536,P27695,Q13557,P14174,Q13555,O43865,P61586,P08183,Q9UHD1,P05067,Q00535,O75844,P21796 13 +Organic acid metabolic process 0.3176280773827071 2.6027826356464714 0.009247056029223 1.0 0.0354703006166214 283 Q9BZF3,Q8N4Q0,Q8TB61,Q9NUJ1,Q9BWD1,Q8NCC3,P07099,Q14914,Q13126,P21796,P14174,Q9HB40,O15382,P09622,Q15800,P41440,O60725,Q8N8N7,P05067,Q15185,O15118,P11182,Q06481,P40939,Q9UKG9,Q9Y6X9,O14880,Q16775,P50542,Q15067,Q9H2D1,O15254 32 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.732912380804443 2.6000763943350766 0.0093203009297258 1.0 0.0357081571484853 3 Q86X55 1 +Hormone metabolic process 0.5868754933610467 2.597262435061974 0.0093970097690108 1.0 0.0358723087638635 28 P30536,Q9HB40,P42892,Q6NUM9,O75844 5 +Positive regulation of macrophage chemotaxis 0.6628060886829972 2.5961877970707183 0.0094264528043477 1.0 0.0358848338368466 2 P28482 1 +Positive regulation of macrophage migration 0.6628060886829972 2.5961877970707183 0.0094264528043477 1.0 0.0358848338368466 2 P28482 1 +Regulation of macrophage proliferation 0.6628060886829972 2.5961877970707183 0.0094264528043477 1.0 0.0358848338368466 2 P28482 1 +Regulation of systemic arterial blood pressure 0.875635451106916 2.596112462780229 0.0094285199036396 1.0 0.0358848338368466 8 P42785,P61586,P09493 3 +Protein trimerization 0.8024227823496609 2.5933614954533253 0.0095042812593604 1.0 0.035934319077822 4 P14174 1 +Negative regulation of chondrocyte differentiation 0.6621442753143674 2.5925647054581984 0.0095263259355142 1.0 0.035934319077822 2 Q06124 1 +Negative regulation of cartilage development 0.6621442753143674 2.5925647054581984 0.0095263259355142 1.0 0.035934319077822 2 Q06124 1 +Positive regulation of neuroblast proliferation 0.6621442753143674 2.5925647054581984 0.0095263259355142 1.0 0.035934319077822 2 O60341 1 +Dopaminergic neuron differentiation 0.6621442753143674 2.5925647054581984 0.0095263259355142 1.0 0.035934319077822 2 P55145 1 +Embryonic skeletal joint morphogenesis 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.035934319077822 2 O95747 1 +Lung associated mesenchyme development 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.035934319077822 2 Q13308 1 +Embryonic skeletal joint development 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.035934319077822 2 O95747 1 +Nephron tubule formation 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.035934319077822 2 O95747 1 +Limb joint morphogenesis 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.035934319077822 2 O95747 1 +Lipoprotein metabolic process 0.6886135183006814 2.5916272277228383 0.0095523213749257 1.0 0.0360110051358412 17 Q9BQE5,Q9NUJ1 2 +Regulation of glycogen catabolic process 0.6604897418927923 2.583499893354696 0.0097803497345219 1.0 0.0366748689749978 2 P62140 1 +Detection of biotic stimulus 0.8653489110540438 2.582494820870061 0.0098088834433589 1.0 0.0367601787535315 5 P30536 1 +Cellular response to endogenous stimulus 0.3287390926730775 2.5809815256813433 0.0098519853824505 1.0 0.0368999523222486 209 Q9UQB8,P26358,Q86X55,Q14103,P42785,Q92542,Q00535,Q15043,P49815,O95831,P08670,Q9Y4I1,P61586,Q13526,Q7L576,P17844,P05067,Q15185,O15118,Q92896,P27695,P09874,O43865,Q99523,P78527,Q06481,P43490,O95429,Q9Y4G8,O75844,O43823,Q8IWV8 32 +Regulation of protein neddylation 0.7279046673286885 2.575041819051637 0.0100227967575285 1.0 0.0374294337196543 3 P46777,Q9BTE7 2 +Organophosphate catabolic process 0.551390322482798 2.5742824646114237 0.0100448230061618 1.0 0.0374676614009181 33 Q8WTV0,Q8NHP8,P00813,Q8NCC3,Q96DE0,P49773 6 +Positive regulation of low density lipoprotein receptor activity 0.7264803262774546 2.5679072456344625 0.0102314529022387 1.0 0.0380814701378606 3 Q9Y2B0 1 +T cell mediated immune response to tumor cell 0.7264270332710112 2.5676401786196523 0.0102393380216494 1.0 0.0380814701378606 3 P04439 1 +Immune response to tumor cell 0.7264270332710112 2.5676401786196523 0.0102393380216494 1.0 0.0380814701378606 3 P04439 1 +Sperm dna condensation 0.6565188616810118 2.5617030063031203 0.0104160347579338 1.0 0.0386033182123629 2 Q96SB4 1 +Relaxation of cardiac muscle 0.7250679092936727 2.5608262673408637 0.0104423560936712 1.0 0.0386757159638878 3 Q13557 1 +Body fluid secretion 0.7166109517423804 2.5606452467114584 0.0104477980349269 1.0 0.0386757159638878 14 P00813,P00403,Q13505 3 +Cellular response to prostaglandin stimulus 0.7245945051307304 2.5584515466782483 0.0105139470944433 1.0 0.0388301265149806 3 P62873,O43823 2 +Response to prostaglandin e 0.7245945051307304 2.5584515466782483 0.0105139470944433 1.0 0.0388301265149806 3 P62873,O43823 2 +Response to prostaglandin 0.7245945051307304 2.5584515466782483 0.0105139470944433 1.0 0.0388301265149806 3 P62873,O43823 2 +Cellular response to prostaglandin e stimulus 0.7245945051307304 2.5584515466782483 0.0105139470944433 1.0 0.0388301265149806 3 P62873,O43823 2 +Negative regulation of sodium ion transport 0.7932197418280542 2.5510128988710283 0.0107410350448704 1.0 0.0395768224609835 4 Q13557 1 +Zinc ion homeostasis 0.7217936858708904 2.5443878394248816 0.0109469461870794 1.0 0.0400635353443672 3 Q15043 1 +Icosanoid metabolic process 0.6919435739749629 2.5439138925929825 0.0109618103334669 1.0 0.0400635353443672 16 O14880,P14174,Q8N4Q0,P07099,Q14914,Q8N8N7,Q15185 7 +Negative regulation of response to external stimulus 0.5168382267053003 2.543813811631233 0.0109649514127969 1.0 0.0400635353443672 43 P14174,Q9UMX5,O75531,P00813,P80303,Q14166,P19474 7 +Peptide catabolic process 0.8325175838842683 2.543138199462992 0.0109861766912615 1.0 0.0401080637849847 9 Q9NZ08,P55786,P42892 3 +Folic acid containing compound catabolic process 0.652878888153547 2.541671165119826 0.0110323913271201 1.0 0.040230567570382 2 Q8IYS1 1 +Regulation of lipid localization 0.6034862625660432 2.5401920779870877 0.0110791604288891 1.0 0.0403683996699554 24 P30536,P14174,Q9BZF3,Q8WTV0,O15260 5 +Positive regulation of lipid catabolic process 0.720935598790003 2.5400743254843925 0.0110828913505462 1.0 0.0403683996699554 3 P31751 1 +Glycoprotein catabolic process 0.7207371151250364 2.539076247028049 0.0111145597538644 1.0 0.0404605623113186 3 O60502 1 +Regulation of defense response 0.4054501664949816 2.5369627164299167 0.0111818862130836 1.0 0.0406823519006067 84 P60900,P04439,Q6P1A2,O75531,Q96KB5,P00813,P78527,Q9NZ08,Q06481,P53634,Q15366,P09429,Q14166,P19474,O60828,Q9NUD5,P05067,O75844 18 +Phospholipid metabolic process 0.4466900598926474 2.5342936315992923 0.0112674272370321 1.0 0.0409353965725103 66 Q9Y217,Q6P1A2,Q9HCL2,Q8WTV0,Q8NHP8,Q8NCC3,P35790,O15269,Q9NPH0,Q9UHD1,Q99943,Q86YN1,Q05655,P40939,Q96N66,Q99570,Q01968,Q6UWP7,O14735,Q10713 20 +Regulation of bone mineralization 0.7890295296494807 2.5316592428397495 0.011352425588514 1.0 0.0411849412332163 4 O75844 1 +Convergent extension 0.6508934480476567 2.5307239620736746 0.0113827389973066 1.0 0.0412478272901261 2 Q13308 1 +Engulfment of apoptotic cell 0.6499007279947118 2.5252448629998714 0.0115617699586261 1.0 0.0418012570290259 2 P84095 1 +Response to endogenous stimulus 0.3155701706186952 2.5242978704117753 0.0115929651789254 1.0 0.0418902141428371 261 P30536,Q9UQB8,P26358,Q86X55,Q14103,P42785,P09601,Q92542,Q00535,Q15043,P49815,O95831,P08670,Q9Y4I1,P61586,Q15392,Q13526,P04818,Q7L576,P17844,P05067,Q15185,O15118,Q92896,P27695,P09874,O43865,Q99523,P78527,Q06481,P40939,P43490,O95429,Q9Y4G8,O75844,O43823,Q8IWV8,P16278 38 +Regulation of autophagy 0.4044725116774024 2.52373936067029 0.0116113982389329 1.0 0.0418999443586564 84 P30536,O00267,P09601,O15269,Q9NZJ7,Q00535,P21796,P49815,Q93050,Q9Y6K9,Q9NNW5,P07602,P19474,O15118,Q8IYI6,Q9Y487,P10619,O75844,P09429,Q9NV70 20 +Regulation of microtubule based movement 0.7872504125762643 2.5234282377196715 0.0116216778173265 1.0 0.0418999443586564 4 Q9Y6A4,P27695 2 +Heme transport 0.6495698213103969 2.5234176817318628 0.0116220267313265 1.0 0.0418999443586564 2 O75027 1 +Iron coordination entity transport 0.6495698213103969 2.5234176817318628 0.0116220267313265 1.0 0.0418999443586564 2 O75027 1 +Methylglyoxal metabolic process 0.7870860927152248 2.5226676081894186 0.0116468432110461 1.0 0.0419418331158126 4 Q16775,Q04760,Q99497 3 +Positive regulation of actin filament polymerization 0.7630686529662573 2.5211146563243347 0.0116983727168762 1.0 0.042055914586236 11 Q9UQB8,P61586,O95429 3 +Lens development in camera type eye 0.7854452997756356 2.5150686342494946 0.0119009213135483 1.0 0.0427116069276755 4 P08670 1 +Protein transmembrane import into intracellular organelle 0.7181937152717665 2.5139467533552224 0.0119388457771323 1.0 0.0428235348529645 13 O95831,Q99595,O60830 3 +Snrna transport 0.7155125149340955 2.5127607318804315 0.0119790549490805 1.0 0.0429161494351795 3 Q09161 1 +Hydrogen peroxide biosynthetic process 0.7154782695222988 2.5125879660879105 0.0119849221597614 1.0 0.0429161494351795 3 Q15067 1 +Sterol transport 0.5899728615532128 2.5112927596991415 0.0120289892019389 1.0 0.0430254672861699 25 P30536,Q9BZF3,Q8WTV0,P61916,O15118 5 +T cell tolerance induction 0.6472534745201917 2.5106159972968576 0.0120520718935948 1.0 0.0430595665855472 2 Q96J02 1 +Lymphocyte anergy 0.6472534745201917 2.5106159972968576 0.0120520718935948 1.0 0.0430595665855472 2 Q96J02 1 +Ion transmembrane transport 0.3653200188100546 2.506939408731936 0.0121781585510662 1.0 0.0433092960608583 138 P00403,Q8TB61,Q9UHD1,Q9UHG3,Q15043,P21796,Q70HW3,O43772,Q9HD20,P41440,P05067,Q9UDW1,P27695,O43865,P31930,Q9UBX3,O75844,P00846,Q9HC07,P45880,Q13423,P08183,Q9Y619,Q9H2D1 24 +Positive regulation of nuclear cell cycle dna replication 0.6455989410986166 2.5014596976858083 0.0123682518865031 1.0 0.0437953253429604 2 O95785 1 +Cell adhesion molecule production 0.7816118342788472 2.4972877320511375 0.0125147365223439 1.0 0.0442154893474252 4 Q5KU26,P41440 2 +Vitamin transmembrane transport 0.8440929517077582 2.4909863831359056 0.0127389001928044 1.0 0.0448330285855288 5 Q8WTV0,Q9H2D1 2 +Vitamin transport 0.8440929517077582 2.4909863831359056 0.0127389001928044 1.0 0.0448330285855288 5 Q8WTV0,Q9H2D1 2 +Purine deoxyribonucleotide catabolic process 0.7801027943907992 2.490277899388232 0.0127643246513213 1.0 0.0448976466429433 4 P00813 1 +Regulation of modification of synaptic structure 0.8438290719296548 2.4898440634936674 0.0127799153294838 1.0 0.0449027870835817 5 Q9UQB8,Q7L576,P61586 3 +Entry into host 0.57220634257518 2.488876978253208 0.0128147299556073 1.0 0.0449825932050274 28 Q8WTV0,O15118,Q14108,P19474 4 +Response to mercury ion 0.6432825943084114 2.488623726892297 0.0128238607437869 1.0 0.0449825932050274 2 Q99497 1 +Mating 0.7786555806973463 2.483549741314766 0.0130080166062604 1.0 0.0454998610072108 4 P00813 1 +Positive regulation of b cell activation 0.7212935823678066 2.47925692022502 0.0131656434915652 1.0 0.0459532290128438 12 O96028,P00813,P14174,Q5JVF3 4 +Vacuolar acidification 0.8175603826668835 2.474692493839564 0.0133350937436833 1.0 0.0464681227164755 9 Q8N511,Q9Y487,P50897,O75503,Q93050 5 +Endocrine process 0.7747518123527348 2.465373975821462 0.0136870313471333 1.0 0.0476422624547532 4 P61586 1 +Unsaturated fatty acid metabolic process 0.6549602451142942 2.461211187629889 0.0138468832056377 1.0 0.0481459462007842 18 P14174,Q8N4Q0,P07099,Q14914,Q8N8N7,Q15185 6 +Response to zinc ion 0.8364057831559683 2.457645619343621 0.0139851100331038 1.0 0.0485734204209881 5 P30536 1 +Protein dna covalent cross linking repair 0.6376571806750564 2.4573672379702054 0.0139959531637636 1.0 0.0485845321184499 2 P55072 1 +Protein processing 0.5176544956254981 2.456307711124728 0.0140372903054393 1.0 0.0487014285924521 40 P09874,Q6P1A2,O75976,P50579,Q15392,Q5JRX3,Q99797,P42892,Q99538,P35579,O75503,Q92542,Q10713,O75844,Q92896 15 +B cell apoptotic process 0.835604006110811 2.4541605785267735 0.0141213906627724 1.0 0.0489664806615283 5 P14174 1 +Response to lead ion 0.772155440844877 2.453263575704857 0.0141566565576094 1.0 0.0489818775613313 4 P05067 1 +Response to oxygen levels 0.4477258301110794 2.4513306409300477 0.0142329146553559 1.0 0.0491216586989254 59 Q96A26,O95831,Q8N511,P00846,P00813,P61586,Q13526,Q9Y487,P09601,P52789,P30519,P55786 12 +Organic hydroxy compound transport 0.556164426046112 2.448756826690932 0.0143350191857993 1.0 0.0494107277358681 30 P30536,Q9BZF3,Q8WTV0,P61916,O15118 5 +Regulation of monocyte chemotaxis 0.7027506304783954 2.4481275878222393 0.0143600794891076 1.0 0.049470279258953 3 P09429 1 +Protein insertion into membrane 0.5665702134547356 2.4339890301828966 0.0149334476604532 1.0 0.0511406214061642 27 P46379,O43681,Q9Y5J9,O60220,Q9Y5L4,Q9NS69 6 +Purine ribonucleoside metabolic process 0.8382438032702351 2.432448694599237 0.0149971160182187 1.0 0.0512482093611818 8 O60725,P00813,Q13126 3 +Ribonucleoside metabolic process 0.8382438032702351 2.432448694599237 0.0149971160182187 1.0 0.0512482093611818 8 O60725,P00813,Q13126 3 +Production of sirna involved in rna interference 0.7673474943367687 2.4307915468461276 0.0150658795942248 1.0 0.0513727096034836 4 O75569 1 +Neutrophil mediated immunity 0.6317008603573859 2.4241431115868903 0.0153445572191643 1.0 0.0521829885955103 2 O75083 1 +Purine nucleotide catabolic process 0.7107249595762318 2.422797486329171 0.0154015097956294 1.0 0.0523206821277504 12 P49773,P00813 2 +Regulation of neuron projection development 0.4396322105489635 2.421807546400474 0.0154435269666652 1.0 0.0523713737635591 64 Q9UQB8,O14976,P08670,Q13555,Q9H2U1,Q14108,Q86X55,Q9NR77,P61586,Q7L576,O60828,P10586,Q9Y4G8 13 +Middle ear morphogenesis 0.7640595301869978 2.4153893534152258 0.0157183973438279 1.0 0.053226496279899 4 O75569,O95747 2 +Positive regulation of lipid localization 0.7091009605502916 2.4140901424228556 0.0157745591765026 1.0 0.053359818055269 12 Q8WTV0,P14174 2 +Regulation of blood circulation 0.5849933950100228 2.4111763797876185 0.015901156485454 1.0 0.0535316475749715 24 P00813,P61586,P42892,P09493 4 +Regulation of b cell proliferation 0.8255520896366041 2.41034687070761 0.0159373600301697 1.0 0.053607657299302 5 P00813,P14174 2 +Vitamin d metabolic process 0.6951340615690169 2.4093134385296007 0.0159825650856544 1.0 0.0536352606570429 3 Q99538,P38435 2 +Glycosylceramide metabolic process 0.6951340615690025 2.40931343852953 0.0159825650856575 1.0 0.0536352606570429 3 P06280,Q05655 2 +Glycosylceramide catabolic process 0.6951340615690025 2.40931343852953 0.0159825650856575 1.0 0.0536352606570429 3 P06280,Q05655 2 +Antigen processing and presentation of endogenous antigen 0.8250182795742099 2.40801382928975 0.0160395734299427 1.0 0.0537697936290697 5 Q9NZ08,P10321 2 +Antigen processing and presentation of endogenous peptide antigen 0.8250182795742099 2.40801382928975 0.0160395734299427 1.0 0.0537697936290697 5 Q9NZ08,P10321 2 +Diterpenoid biosynthetic process 0.6280608868299209 2.403774051654091 0.0162267992551656 1.0 0.0542258338937082 2 O94788 1 +Negative regulation of hormone metabolic process 0.6280608868299209 2.403774051654091 0.0162267992551656 1.0 0.0542258338937082 2 P05023 1 +Peptidyl methionine modification 0.7612387599107375 2.402153368059732 0.016298873386086 1.0 0.0543916164302754 4 P50579 1 +Cellular response to oxygen containing compound 0.3286020861977837 2.400694431698564 0.0163639948125173 1.0 0.054491894869924 200 P30536,Q9UQB8,P26358,Q8WTV0,Q9H2U1,Q14103,Q92542,Q00535,Q15043,P49815,O95831,P14174,P08670,Q9Y4I1,P61586,Q5KU26,Q7L576,P05067,P09493,P27695,P09874,O43865,P78527,Q99720,Q06481,P31751,O15111,P43490,Q9Y4G8,O43823,Q8IWV8,P09429,P30044 33 +Developmental maturation 0.5173570595043874 2.4003042889563453 0.0163814480082067 1.0 0.054491894869924 38 Q9Y2W6,P07737,P61586,Q15125,P04818,P09622,Q08J23,O14965,Q9NZJ7,P05067 10 +Lateral ventricle development 0.627399073461291 2.4000652493473984 0.0163921496210344 1.0 0.054491894869924 2 Q9Y5K5 1 +Negative regulation of myeloid leukocyte differentiation 0.6273990734612906 2.4000652493473984 0.0163921496210344 1.0 0.054491894869924 2 P35222 1 +Negative regulation of peptidyl serine phosphorylation 0.626737260092661 2.3963548044173986 0.016559052617151 1.0 0.0546563501085537 2 P63244 1 +Cellular response to molecule of bacterial origin 0.5612022983774289 2.3941514362456395 0.0166588690977693 1.0 0.054902371349768 27 P30536,O43823,P14174,Q8WTV0,P61586 5 +G quadruplex dna unwinding 0.6918807795477706 2.3926799520435957 0.0167258238173073 1.0 0.055054032202385 3 Q9H2U1 1 +Negative regulation of cell projection organization 0.5590971271857775 2.390983420163765 0.0168033116697781 1.0 0.0552518618588254 28 O14976,Q05655,P08670,P43034,Q86X55,Q9NR77,P61586,Q00535,Q9Y4G8 9 +Negative regulation of leukocyte apoptotic process 0.8200544539313899 2.386288752556324 0.0170193820921589 1.0 0.055846769529046 5 P00813,P14174 2 +Negative regulation of lymphocyte apoptotic process 0.8200544539313899 2.386288752556324 0.0170193820921589 1.0 0.055846769529046 5 P00813,P14174 2 +Phospholipid transport 0.7364026884835972 2.385983890394519 0.0170334971920573 1.0 0.0558642456928362 11 Q8WTV0,Q14108,P61916 3 +Response to hormone 0.347959582159669 2.3824963747246355 0.0171957012948227 1.0 0.0563090558629022 170 P30536,Q9UQB8,P42785,P09601,Q15043,P49815,O95831,Q9Y4I1,P61586,Q15392,Q7L576,Q15185,O15118,P27695,P09874,O43865,Q99523,P78527,Q06481,P43490,O43823,P16278 22 +Pigment biosynthetic process 0.5802758115163806 2.377984421524493 0.0174075613308508 1.0 0.0568534832599119 24 P30536,P00813,P22830 3 +Regulation of cell shape 0.537680137719613 2.3743967769813916 0.0175776502590241 1.0 0.0573441244088786 31 Q9UQB8,Q6XZF7,P63167,P61586,P35580,Q7L576,P35579,P09493,O75844 9 +Bile acid metabolic process 0.8251200249184606 2.374264112610517 0.0175839676640818 1.0 0.0573441244088786 8 Q9BZF3 1 +Transition metal ion homeostasis 0.5797043403857965 2.37395595468827 0.0175986496578011 1.0 0.0573625729358891 24 Q8N511,Q9Y487,Q96NT0,P09601,P30519,P05067,Q15043 7 +Regulation of smooth muscle contraction 0.8165510487987065 2.3709223643913906 0.0177437577245509 1.0 0.0577171566516099 5 P00813 1 +Phosphatidylinositol dephosphorylation 0.7537612481887089 2.366966605280633 0.017934550990946 1.0 0.0581591867849251 4 Q01968,Q10713 2 +Regulation of b cell activation 0.6607073832764221 2.3623737772986875 0.0181583238147247 1.0 0.0586156963770392 16 O96028,P00813,P14174,Q5JVF3 4 +Fc gamma receptor signaling pathway 0.6855057326542597 2.3599903600446126 0.0182754099552218 1.0 0.0589337928337848 3 Q06481 1 +Negative regulation of leukocyte mediated immunity 0.7518010637437111 2.3577186239855537 0.0183876244277527 1.0 0.059175564993821 4 P09601 1 +Cellular transition metal ion homeostasis 0.6020825767018897 2.3573333724288896 0.0184067139722048 1.0 0.0592070212587722 21 Q8N511,Q9Y487,Q96NT0,P09601,P05067,Q15043 6 +Carbohydrate derivative transport 0.6694571782630215 2.353329918241902 0.0186061175736473 1.0 0.0596973666320559 15 L0R6Q1,Q8TB61,Q8WTV0,P07602,P41440,P61916 6 +Response to manganese ion 0.8121578761192038 2.351614621275973 0.0186921296591777 1.0 0.0599430757385135 5 P30536 1 +Intracellular lipid transport 0.7295387608993498 2.3508671368740583 0.0187297203093974 1.0 0.0600333344863995 11 O15118,O43772 2 +Regulation of lipid metabolic process 0.4710818379313115 2.349522171039114 0.0187975245963771 1.0 0.060159650722343 49 P30536,Q05655,Q6P1A2,P61916,P05023,Q8WTV0,P34913,P11802,Q06481,P07602,P31751,Q9H6K4,Q96N66,Q9UHD1,Q99570,Q9NZJ7,Q9UBM7,O75844 18 +Muscle system process 0.4412068983830288 2.347783371058618 0.0188855015407778 1.0 0.0604107940579687 55 P09874,Q13555,P00813,P61586,P06753,P09601,P09493,P67936 8 +Glycerophospholipid biosynthetic process 0.5212825069771677 2.3473447925010973 0.0189077488055797 1.0 0.0604515349136142 34 Q8WVX9,O15228,Q9Y217,Q01968,O00443,Q6P1A2,Q9HCL2,Q8NF37,P35790,Q99943,Q9NPH0,Q96N66,Q6UWP7,Q99570,Q10713,O14735 16 +Negative regulation of neuron differentiation 0.8460033762774365 2.3427748791723086 0.0191409284736798 1.0 0.0610741673587898 7 P61586 1 +Bicarbonate transport 0.6168100595632103 2.340500924257796 0.0192578907466458 1.0 0.0614165346641651 2 Q9UHQ9 1 +Negative regulation of mitochondrial fusion 0.6803762550225652 2.333596322842298 0.019616869324837 1.0 0.0624673454051425 3 Q99536 1 +Maintenance of organelle location 0.6787833961196701 2.3253835865940307 0.0200514583401905 1.0 0.063659874730395 3 Q5T280 1 +Maintenance of centrosome location 0.6787833961196701 2.3253835865940307 0.0200514583401905 1.0 0.063659874730395 3 Q5T280 1 +Ventricular septum morphogenesis 0.6776452061333145 2.319510296981164 0.0203673834624831 1.0 0.0645339428153253 3 O96028 1 +Positive regulation of activated t cell proliferation 0.6771973982352439 2.317198418302458 0.0204929256567822 1.0 0.0648670495390977 3 Q9HCL2 1 +Negative regulation of fat cell differentiation 0.8042465397497173 2.3167361186467157 0.0205181107759528 1.0 0.0649144410612028 5 Q8N4Q0 1 +Glycerophospholipid metabolic process 0.4668790018117931 2.307877845719623 0.0210059315951376 1.0 0.066292801002331 49 Q9Y217,Q01968,Q6P1A2,Q9HCL2,Q8WTV0,Q8NCC3,P40939,P35790,Q99943,Q9NPH0,Q96N66,Q6UWP7,Q99570,Q10713,O14735 15 +Ribonucleotide catabolic process 0.7517934067496401 2.3073627852933987 0.0210346040574589 1.0 0.0663503441137513 10 P49773,P00813 2 +Regulation of cellular ph 0.5940285162525227 2.3036489941981135 0.0212423551963794 1.0 0.0668183176700506 21 Q8N511,Q9HC07,Q9Y487,P50897,O75503,Q9UHD1,Q93050 7 +Regulation of ph 0.5940285162525227 2.3036489941981135 0.0212423551963794 1.0 0.0668183176700506 21 Q8N511,Q9HC07,Q9Y487,P50897,O75503,Q9UHD1,Q93050 7 +Positive regulation of stem cell differentiation 0.7399567165202325 2.301626052398062 0.0213562696393871 1.0 0.0670985911161369 4 Q9Y6C9 1 +Spleen development 0.6740105181290812 2.3007277166065405 0.0214070264189256 1.0 0.0671401842821855 3 Q5JVF3 1 +Regulation of endoplasmic reticulum tubular network organization 0.6739914900079083 2.300629279450314 0.0214125945875669 1.0 0.0671401842821855 3 P57088 1 +Vasoconstriction 0.800016890224065 2.2980316962986156 0.0215599851927772 1.0 0.06737050200549 5 P61586 1 +Intracellular protein transmembrane transport 0.5931124341882599 2.2975240318668475 0.0215888937543344 1.0 0.06737050200549 21 O95831,Q99595,O60830,P50542,P31751 5 +Positive regulation of cellular respiration 0.6722939424031624 2.2918429386724513 0.0219147079255281 1.0 0.0681790913238696 3 Q99497,P55072 2 +Iron ion transmembrane transport 0.672293942403158 2.291842938672428 0.0219147079255295 1.0 0.0681790913238696 3 O75027,Q15043 2 +Phenotypic switching 0.6714125014499784 2.2872771693569702 0.0221796502119306 1.0 0.0689021782732314 3 P26358 1 +Layer formation in cerebral cortex 0.7357887780096282 2.281801026018476 0.0225010901911941 1.0 0.069526946648143 4 Q00535,Q96N66 2 +Secretory granule organization 0.669714390071082 2.2784743602805673 0.0226983304227172 1.0 0.0699412714124884 3 P43034 1 +Modification of synaptic structure 0.7746274215102895 2.2752114905326626 0.022893245902537 1.0 0.0703912081410019 9 Q9UQB8,Q7L576,P61586,P07737 4 +Lymphocyte costimulation 0.6052283256121849 2.274870668397745 0.0229136893712607 1.0 0.0703912081410019 2 Q06124 1 +Cytoplasmic microtubule organization 0.6743749573958662 2.2736207685362935 0.0229887976539282 1.0 0.0704856719191355 13 P43034,P61586,Q96CW5,Q9UHD1,Q96ED9 5 +Regulation of sterol transport 0.7730379415773609 2.2677404024029877 0.0233450337780927 1.0 0.0712220455862392 9 P30536,Q9BZF3 2 +Growth hormone secretion 0.6039046988749248 2.2673380424002554 0.0233695832128488 1.0 0.0712220455862392 2 Q06124 1 +Lipid homeostasis 0.5646255489733429 2.267060706851737 0.0233865174984062 1.0 0.0712241040823527 24 Q8WTV0,Q9Y6C9,Q15067,O15260,P61916,O15254,O15118 7 +Positive regulation of blood circulation 0.7928442482239787 2.2662216053576665 0.0234378184536585 1.0 0.0713272713527383 5 P00813 1 +Response to angiotensin 0.732502844805817 2.2661396108224685 0.0234428366670658 1.0 0.0713272713527383 4 O43865 1 +Negative regulation of protein export from nucleus 0.6672647707277221 2.2657601148667 0.0234660746520072 1.0 0.0713638136306975 3 Q00535 1 +Negative regulation of leukocyte migration 0.8539450431582196 2.263867767292063 0.0235822489473997 1.0 0.0716303596649116 6 P00813,P14174 2 +Modification of postsynaptic structure 0.8276011910631959 2.263598827245945 0.0235988000532292 1.0 0.0716303596649116 7 Q9UQB8,Q7L576,P61586 3 +Protein localization to synapse 0.7124097733966677 2.2626381602516012 0.0236580037494711 1.0 0.071771497115601 11 Q9UQB8,Q00535 2 +Plasma membrane raft assembly 0.666520126038551 2.2618915141775027 0.0237041067909093 1.0 0.0717786101777132 3 P41440 1 +Plasma membrane raft organization 0.666520126038551 2.2618915141775027 0.0237041067909093 1.0 0.0717786101777132 3 P41440 1 +Regulation of t cell migration 0.7906879411798208 2.2566361688077916 0.024030818389739 1.0 0.0725605138646943 5 P61586,P05067 2 +Ventricular cardiac muscle tissue development 0.7906192881424031 2.256330815458602 0.0240499208935509 1.0 0.072583711870565 5 P09493 1 +Negative regulation of cell population proliferation 0.3851218000016357 2.2540991192438304 0.0241899330751913 1.0 0.0729716253563911 94 P30536,P49815,O75569,Q9NPI1,P61586,Q9NR77,Q15392,P09601,Q96DY7,P05067,P09493,Q9Y4G8 12 +Cellular response to nitrogen compound 0.350983564342743 2.2493507609335097 0.0244901886676147 1.0 0.0736676001757498 130 Q9UQB8,P26358,Q14103,Q92542,Q15043,P49815,O95831,P08670,Q9Y4I1,Q5KU26,Q7L576,P41440,P05067,P27695,P09874,O43865,P78527,Q06481,O60828,P43490,Q9NUD5,Q9Y4G8,Q8IWV8 23 +Cellular response to peptide 0.4205415773228266 2.2458607093575513 0.024712931241321 1.0 0.0742750230331028 67 P49815,Q9UQB8,Q13243,P27695,P09874,P08670,O43865,Q9Y4I1,P78527,Q06481,Q7L576,Q99538,P31751,P43490,P05067,Q00535,Q15043 17 +Positive regulation of telomere capping 0.6630254882489219 2.243713189452639 0.0248508609395301 1.0 0.0742808813273251 3 P28482,Q14103 2 +Caveolin mediated endocytosis 0.6630254882489198 2.243713189452625 0.024850860939531 1.0 0.0742808813273251 3 Q9UNF0,P28482 2 +Cardiac neural crest cell differentiation involved in heart development 0.6630254882489197 2.243713189452625 0.024850860939531 1.0 0.0742808813273251 3 P60953,P28482 2 +Outer ear morphogenesis 0.6630254882489102 2.2437131894525773 0.0248508609395341 1.0 0.0742808813273251 3 O75569,P28482 2 +Stress granule disassembly 0.6626944720291181 2.2419893626681 0.0249620598069051 1.0 0.0745577312653613 3 Q07866,P55072 2 +Proximal distal pattern formation 0.6623634558093326 2.2402651978543795 0.0250737111992369 1.0 0.0747507074964118 3 O94788,O95747 2 +Maintenance of protein localization in organelle 0.6590345805364612 2.238482166818468 0.0251896290733855 1.0 0.0750259055250413 14 P30536,P24390,Q00535,Q9UH99,Q00839 5 +Cellular response to hormone stimulus 0.3627339560856887 2.237657291281283 0.0252434123844564 1.0 0.0751156971515006 117 Q9UQB8,Q86X55,P42785,Q15043,P49815,O95831,Q9Y4I1,P61586,Q7L576,P17844,Q15185,O15118,Q00839,P27695,P09874,O43865,P78527,Q06481,P43490,O43823 20 +Regulation of leukocyte migration 0.5515739594423754 2.234643626960505 0.0254407542776466 1.0 0.0754692513497398 25 P14174,P00813,P61586,P09601,P09429,Q99538,O95747,P05067 8 +Organophosphate ester transport 0.5681957067757135 2.234032039976825 0.0254809649774294 1.0 0.0754692513497398 23 Q9H2D1,Q8WTV0,Q14108,P08183,P41440,P61916 6 +Organophosphate metabolic process 0.3026501499360145 2.2294199397725403 0.0257859767384152 1.0 0.0763015214848077 238 Q9Y217,P00403,Q6P1A2,P17812,P12277,Q8WTV0,P43034,Q8NHP8,Q8TB61,Q9HCL2,Q8NCC3,Q969T7,P35790,O15269,Q9NPH0,Q9H773,P49773,Q9UHD1,Q13057,P00813,P61586,P04818,P62826,P09622,O00178,Q99943,P55263,Q86YN1,P05067,P12532,P09874,Q05655,P32321,P50897,P40939,Q96DE0,Q96N66,Q99570,P43490,Q9NZ01,Q9UKG9,P04183,P00846,Q01968,P56134,Q9UMR5,P52789,Q6UWP7,O14735,Q10713 50 +Purine containing compound salvage 0.8192892362633997 2.2276062222897433 0.0259067853765528 1.0 0.0765876873736605 7 P00813,Q13126 2 +Chemical homeostasis 0.339224824570057 2.2253593411909196 0.0260571247226641 1.0 0.0769963201939812 171 P30536,Q9HCL2,Q8WTV0,Q9Y6C9,P42785,P09601,Q9UHD1,Q00535,Q15043,Q93050,Q9HD20,P30519,P05067,O15118,P27695,Q8N511,P09874,Q9Y487,Q9BZE9,P50897,Q06481,O15260,P61916,Q9HC07,Q13557,Q15067,P09429,P52789,O15254 29 +Regulation of cell migration involved in sprouting angiogenesis 0.7238423409908779 2.2247282434395323 0.026099487053329 1.0 0.0770856597169887 4 P61586 1 +Purine deoxyribonucleotide metabolic process 0.7830625848980551 2.2226562920722484 0.0262389852722875 1.0 0.0774257151302968 5 P00813,Q96DE0 2 +Response to food 0.782814201346547 2.2215472831062133 0.026313915901678 1.0 0.0775388268294232 5 Q9UMX5 1 +Regulation of muscle system process 0.5268130406394395 2.2204224622725093 0.0263901036750475 1.0 0.0777272933079714 30 P00813,P61586,P09493,Q13555 4 +Regulation of anion transport 0.7334538034492611 2.216991075630822 0.0266237013822143 1.0 0.0783064534869757 10 P14174,O43865 2 +Cell maturation 0.5807980248071568 2.214818065107673 0.0267725547491892 1.0 0.0787078436567284 21 Q9Y2W6,P04818,P09622,O14965,Q9NZJ7,P05067 6 +Mitochondrion organization 0.3360327917986293 2.2133587972358817 0.0268729189255385 1.0 0.078852758649385 176 P30536,Q99595,Q9BUR5,Q9Y6C9,Q99797,O60220,O95298,O14965,Q13505,Q9Y584,Q9NS69,P55786,Q00535,P21796,P49815,O95831,O60830,O00170,Q9BUB7,Q5JRX3,P51970,P27695,P09874,Q86Y39,O75153,Q9Y5J9,Q9H061,O95429,P49257,P50542,P45880,Q69YU5,Q9BZL1,Q9Y5L4,Q10713 35 +Activation of cysteine type endopeptidase activity 0.657155874155028 2.213096005225701 0.0268910274678397 1.0 0.078852758649385 3 Q99538 1 +Maintenance of protein location in cell 0.6037263490181125 2.2130197516031775 0.0268962839445983 1.0 0.078852758649385 19 P30536,O15258,P24390,P52789,Q709C8,Q99497,Q9UH99,Q9H4A6,Q00535,Q00839 10 +Type i interferon production 0.5362069613821 2.2065305934642656 0.0273468705892321 1.0 0.0800261093301838 27 O75531,Q9H2U1,P09884,O60828,P19474,P41440,Q9NUD5 7 +Positive regulation of multicellular organismal process 0.3283684113416151 2.206160513924459 0.0273727629059599 1.0 0.0800650165808933 188 P30536,Q9UQB8,O96028,Q6P1A2,Q9HCL2,Q9H2U1,P55209,P09601,P14174,Q5JVF3,P00813,P61586,Q7L576,P41440,P05067,P09493,P27695,P09874,P04439,P78527,Q9NZ08,Q06481,P40939,O15111,O60828,Q68CQ4,Q9NUD5,Q96QE3,Q969H8,Q13557,P50542,Q92766,P09429,P52789,P16989 35 +Response to insulin 0.4270350953115045 2.2052665750107736 0.0274353938894478 1.0 0.0802112987862605 57 P49815,Q9UQB8,P09874,Q9Y4I1,Q99523,P78527,Q06481,Q7L576,P43490,Q15043 10 +Regulation of membrane potential 0.4280701417114317 2.204404976864756 0.0274958759826691 1.0 0.0803142406920243 55 P30536,Q9UQB8,P09874,P09622,P31751,P05067,Q00535,O75844 8 +Chemical synaptic transmission postsynaptic 0.7008456266248749 2.202594569201993 0.0276233370388137 1.0 0.0805754613211105 11 Q9UQB8,P05067 2 +Regulation of postsynaptic membrane potential 0.7008456266248749 2.202594569201993 0.0276233370388137 1.0 0.0805754613211105 11 Q9UQB8,P05067 2 +Response to acid chemical 0.5629452519615373 2.1971943420299382 0.0280065695199602 1.0 0.081468995820992 23 Q9UQB8,O95831,P26358,P61586,Q8IWV8 5 +Cellular response to camp 0.8378748592459394 2.196830717868936 0.0280325383623443 1.0 0.0815072341404668 6 P05067,Q9Y4G8 2 +Negative regulation of glucose import 0.6529874405457409 2.191288155800855 0.0284309466241445 1.0 0.082214329728418 3 Q06481 1 +Regulation of response to extracellular stimulus 0.7757002742464494 2.1897262960622808 0.0285440928040654 1.0 0.0825039808379445 5 Q9UMX5 1 +Protein insertion into mitochondrial inner membrane 0.8098696871221707 2.186645150059275 0.0287684386131874 1.0 0.0829256998924925 7 Q9Y5L4,Q9Y5J9,O60220 3 +Proteolysis 0.2865921308030982 2.1859721904060856 0.028817639974648 1.0 0.0829256998924925 362 P46777,P63244,P42785,Q8TBC4,Q96F07,P49773,Q9UHG3,P55786,Q9UBW8,Q9UMY4,Q9Y5A7,Q86UV5,O95831,O43765,Q9HB40,O43847,P61586,Q15392,P78318,P09622,P49721,Q86TI2,P19474,P28074,Q9BT78,P05067,Q92896,P48147,P34897,P42892,Q7L5N1,Q8N3C0,Q9NZ08,P10619,Q99497,Q96DE0,Q9H3G5,Q9UBV2,O75844,Q7Z6E9,P46379,Q9UIQ6,P55072,Q93009,Q86Y37,Q96FZ2,Q96HY6,Q6P1A2,P50579,P29144,Q92542,Q8NEZ5,Q92890,Q96JB5,Q5JVF3,Q9NR09,Q9Y4X5,Q5JRX3,Q5T4S7,Q13867,P25788,P38159,O94966,P63208,P09874,Q8WUX9,Q92990,Q9Y263,Q06481,Q8IWV8,P53634,Q10713,P60900,Q99797,O14965,Q9NZJ7,Q00535,P61289,O75832,P20618,O75976,Q15366,Q9GZP4,Q96A26,Q9H7D7,Q15369,P09429,P30044,O75503,Q9BZF9,O15484,P63167,Q9H1I8,Q99538,P35579,P67812,Q9C0D3,Q9C0C9,Q96KB5,P36551,P22695,A0AVT1,Q9Y5X1,Q6P2Q9,P49327,P30260,Q9Y5K5 107 +Response to camp 0.7259072162757145 2.179547711195581 0.0292910043632776 1.0 0.0835233843575563 10 P27695,P05067,Q9Y4G8 3 +Toll like receptor 3 signaling pathway 0.7135967394079676 2.1754880133997947 0.0295935653940464 1.0 0.0841972702079495 4 Q5KU26 1 +Maintenance of dna methylation 0.7134810593760438 2.174930517854666 0.0296353235812829 1.0 0.0842783519832816 4 P26358 1 +Negative regulation of neuron projection development 0.6082670312482787 2.1726695449424445 0.0298051975232886 1.0 0.0846478263887502 18 O14976,P08670,Q86X55,Q9NR77,P61586 5 +Glycolipid biosynthetic process 0.8064307935636154 2.171645602029216 0.0298824045600789 1.0 0.0848291931147216 7 Q8NBX0 1 +Regulation of lipid transport 0.6077850624720561 2.1696460938882636 0.0300336666560099 1.0 0.0849928696641135 18 P30536,O15260,Q9BZF3,P14174 4 +Ion homeostasis 0.3759558214592783 2.169091851367999 0.0300757112231577 1.0 0.0850192663949852 99 P30536,P27695,Q8N511,P09874,Q9HC07,Q13557,Q9Y487,P50897,P09601,P09429,Q9HD20,O75503,P30519,Q9UHD1,P05067,Q00535,Q15043,Q93050 18 +Regulation of amino acid transmembrane transport 0.5866975512905441 2.1688180637984726 0.0300964992744992 1.0 0.0850192663949852 2 O75915 1 +Regulation of l glutamate import across plasma membrane 0.5866975512905441 2.1688180637984726 0.0300964992744992 1.0 0.0850192663949852 2 O75915 1 +L glutamate import across plasma membrane 0.5866975512905441 2.1688180637984726 0.0300964992744992 1.0 0.0850192663949852 2 O75915 1 +Histone h4 k20 methylation 0.7703006019099683 2.1654986392622866 0.0303495194925016 1.0 0.0856578800596538 5 Q14166 1 +Regulation of tolerance induction 0.647467725918575 2.1623288069104274 0.0305928408110001 1.0 0.0861915320012042 3 P09429,Q96J02 2 +Tolerance induction 0.647467725918575 2.1623288069104274 0.0305928408110001 1.0 0.0861915320012042 3 P09429,Q96J02 2 +Regulation of tube size 0.6930007554466583 2.161644280117123 0.0306456055739088 1.0 0.086263715247017 11 Q9HB40,P61586 2 +Protein nitrosylation 0.5850430178689692 2.159286882016482 0.0308279172125911 1.0 0.0867384868540191 2 P04406 1 +Deoxyribonucleoside triphosphate metabolic process 0.7499873231835363 2.1587106276381514 0.030872623765062 1.0 0.0867490701373715 9 Q9H773,P00813,P55263,Q96DE0 4 +Gmp biosynthetic process 0.6619820437228381 2.15779248875196 0.0309439691423751 1.0 0.0868727331576575 12 P00813 1 +Cation transport 0.3441945325212804 2.150892982279254 0.0314846475820778 1.0 0.0880406599347499 143 P30536,P00403,Q9UHD1,Q15043,P21796,Q70HW3,Q13555,P61586,O43772,Q9HD20,P05067,Q9UDW1,P27695,O43865,P31930,O75844,P00846,Q9HC07,Q13423,Q9Y619 20 +Response to oxygen containing compound 0.3001060281747952 2.1491772262866604 0.0316203538413195 1.0 0.0882648085267576 270 P30536,Q9UQB8,P11717,P26358,Q8WTV0,Q9HCL2,Q9H2U1,Q86X55,Q14103,P09601,Q92542,Q13126,Q15043,Q00535,P49815,O95831,P14174,P08670,Q9Y4I1,P61586,Q5KU26,P04818,Q7L576,P05067,P09493,P27695,P09874,O43865,Q99523,P78527,Q99720,Q06481,P40939,P31751,O15111,P43490,Q9Y4G8,O43823,P23378,Q8IWV8,P09429,P16278,P30044 43 +Meiosis ii cell cycle process 0.5830575777630791 2.147836072017663 0.0317267803220056 1.0 0.0883471212831162 2 O60566 1 +Meiotic sister chromatid cohesion centromeric 0.5830575777630791 2.147836072017663 0.0317267803220056 1.0 0.0883471212831162 2 O60566 1 +Protein lipid complex subunit organization 0.766006351620072 2.1461850578400665 0.0318582172242383 1.0 0.088578665213149 5 Q8WTV0 1 +Positive regulation of cell activation 0.4877992777380578 2.143536140687148 0.0320700722963516 1.0 0.0889557986042706 38 O96028,P04439,P14174,Q5JVF3,Q9HCL2,P00813,P61586,P78527,P53634,Q96QE3 10 +Muscle adaptation 0.6502955102982001 2.138866459859876 0.0324464850924777 1.0 0.0897041580025177 13 P09601,P09874,Q13555 3 +Regulation of mitochondrial fusion 0.7052380646027475 2.1351170455215205 0.0327514506339294 1.0 0.0903900218103585 4 Q99536,Q9Y6C9 2 +Vesicle uncoating 0.6415094339622527 2.1309639046174333 0.0330921159562216 1.0 0.0908960626697254 3 O14976,P11142 2 +Purine nucleoside biosynthetic process 0.8216782068184006 2.128765255273288 0.033273686874466 1.0 0.0913553148052295 6 P00813,Q13126 2 +Negative regulation of lymphocyte mediated immunity 0.6408474015226702 2.1274722376742656 0.0333808656439664 1.0 0.0914296454749988 3 P04439,P01889 2 +Regulation of biomineralization 0.7614389004006512 2.1255983493677157 0.0335367171773151 1.0 0.0917603850103378 5 O75844 1 +Ceramide transport 0.7608863022721096 2.1231045482643864 0.0337450919794652 1.0 0.0920761798549641 5 P07602,P08183 2 +Positive regulation of protein binding 0.5439055201485907 2.1183044552731043 0.0341492915663659 1.0 0.0930359610783634 24 Q13526,P62826,P19474,P41440,Q96D46,P05067,Q00535,Q9Y4G8 8 +Neurotrophin trk receptor signaling pathway 0.7595230208678456 2.116949390205788 0.0342641432713459 1.0 0.0932177610812029 5 Q99523,P27695,Q7L576,Q96F07 4 +Purine ribonucleoside salvage 0.7589707352536059 2.1144546894902994 0.0344764508435089 1.0 0.09348648530774 5 Q13126 1 +Nucleoside salvage 0.7589707352536059 2.1144546894902994 0.0344764508435089 1.0 0.09348648530774 5 Q13126 1 +Regulation of phosphatidylinositol 3 kinase activity 0.6369258905280284 2.1067622531473567 0.0351381929662597 1.0 0.0948801174382547 3 Q99570 1 +Positive regulation of lipid kinase activity 0.6369258905280282 2.1067622531473567 0.0351381929662597 1.0 0.0948801174382547 3 Q99570 1 +Negative regulation of protein sumoylation 0.6368752068851393 2.106494281296821 0.035161439342731 1.0 0.0948801174382547 3 Q99497,P35222 2 +Positive regulation of necrotic cell death 0.7571332138813376 2.106149730541051 0.0351913481764643 1.0 0.0948801174382547 5 P30536 1 +Cytokine production involved in immune response 0.7379389011594965 2.101216068299453 0.0356220035144332 1.0 0.0957755729009042 9 Q9H2U1,P09601,P14174 3 +Regulation of nervous system process 0.6812305815097272 2.099876231530936 0.0357397301053188 1.0 0.0959703103292803 11 Q9UQB8,P05067 2 +Positive regulation of protein polymerization 0.5217131805716237 2.0961594261531444 0.0360680508495174 1.0 0.0965256973471718 27 Q9UQB8,P61586 2 +Negative regulation of immune system process 0.4767609528296234 2.093287768960868 0.0363234738247439 1.0 0.097086627262436 40 P04439,P14174,Q9HCL2,O75531,P00813,P09601,Q14166,P19474 8 +Maintenance of location in cell 0.4794675421373146 2.092987722236185 0.0363502505770685 1.0 0.0971173571533617 39 P30536,P27695,P63208,Q13557,P43034,Q5T280,O15258,P24390,O14617,P52789,Q709C8,Q99497,Q9UH99,Q9H4A6,Q00535,Q00839 16 +Negative regulation of centriole replication 0.5734612839179436 2.0922853834649944 0.0364129944363589 1.0 0.0972110160669407 2 P38398 1 +Phosphatidylserine metabolic process 0.7540457414539945 2.092178881662405 0.036422516893432 1.0 0.0972110160669407 5 Q8NCC3 1 +Positive regulation of protein maturation 0.6963680494485918 2.092081905803082 0.0364311894700208 1.0 0.0972110160669407 4 Q6P1A2 1 +Ether biosynthetic process 0.7536864006064765 2.0905515148157563 0.0365682859229621 1.0 0.0974928067407073 5 Q8WVX9,P49327,O00116 3 +Membrane repolarization during cardiac muscle cell action potential 0.6338319064730746 2.090389664325633 0.0365828105847367 1.0 0.0974928067407073 3 P21333 1 +Membrane repolarization during action potential 0.6338319064730746 2.090389664325633 0.0365828105847367 1.0 0.0974928067407073 3 P21333 1 +Anion transmembrane transport 0.486324470139528 2.0889392249827536 0.0367131943290379 1.0 0.0976764600901487 36 P45880,P08183,P41440,Q9Y619,Q9H2D1,Q9UHG3,Q9UBX3,P21796 8 +Positive regulation of chemokine production 0.7874623405728634 2.088476440319289 0.0367548784526867 1.0 0.097746446629823 7 P09601,P05067,P14174 3 +Vascular associated smooth muscle cell proliferation 0.6785351865434679 2.08567632399947 0.0370079524864044 1.0 0.0983136198498814 11 P61586,P09493,P26358 3 +Sensory perception 0.4879454147883992 2.0845131068359946 0.0371135192636147 1.0 0.0984697388122843 35 Q9Y6M9,Q6P4Q7,O75569,O43924,P11047,Q14108,P63173,Q99797,P50897,Q9Y5J9,Q9Y5L4,Q9H6K4,Q9ULX3,Q00535 14 +Neutral lipid biosynthetic process 0.8105095403869905 2.081539459452948 0.0373845562202341 1.0 0.0991306797395946 6 Q8WTV0,Q8NCC3 2 +Negative regulation of signal transduction by p53 class mediator 0.7514717388855165 2.0805156736900465 0.0374782595283662 1.0 0.0993377054054611 5 O75832,P14174 2 +Regulation of smad protein signal transduction 0.6933774834436993 2.0775275568597125 0.0377528945687342 1.0 0.0999406071965325 4 Q01082,P09874,Q8N1F7 3 +Regulation of membrane depolarization 0.7846768539857617 2.076201788835694 0.0378752919122589 1.0 0.1002228790151197 7 P30536,P09874,Q13557 3 +Negative regulation of smooth muscle cell proliferation 0.7590930314803795 2.075700320672336 0.0379216762759822 1.0 0.100303859513168 8 P61586,P09493 2 +Leydig cell differentiation 0.5701522170747937 2.073051584005621 0.0381674791508093 1.0 0.100903102926924 2 O95470 1 +Porphyrin containing compound metabolic process 0.6121273645839435 2.0729172483335474 0.0381799815197061 1.0 0.100903102926924 16 P30536,P30519,P22830 3 +Response to ketone 0.4816722712597436 2.0682668605784658 0.038614936166256 1.0 0.1020101971208325 37 P30536,P09874,O95831,O43823,Q14103,P16278,Q13126 7 +Negative regulation of defense response 0.49130757483755 2.0667272464914883 0.0387598622737033 1.0 0.1023080085596587 32 P04439,Q6P1A2,O75531,Q96KB5,P00813,Q15366,Q14166,P19474 8 +Synaptic vesicle cytoskeletal transport 0.629318367063095 2.0664533612024427 0.0387856918520088 1.0 0.10233368925337 3 O14617 1 +Cytokine production 0.3738414707674981 2.065551318148037 0.0388708651665763 1.0 0.1025158585057092 90 P30536,P04439,Q8IV08,P14174,O43823,O75531,Q9HCL2,Q9H2U1,Q06481,P09601,P19474,P41440,P09884,O15111,O60828,Q9NUD5,P05067 17 +Prostanoid metabolic process 0.6452627581126794 2.0651681031449347 0.0389070974126424 1.0 0.1025688557257383 12 P14174,Q8N4Q0,Q14914,Q8N8N7,Q15185 5 +Positive regulation of toll like receptor signaling pathway 0.7478598457476449 2.064125452161141 0.039005823321065 1.0 0.1027469442474004 5 P41440 1 +Ether metabolic process 0.756572636131033 2.0641132304535 0.0390069818233129 1.0 0.1027469442474004 8 Q8WVX9,P49327,P43034,P34913,P07099,O00116 6 +Membrane lipid metabolic process 0.489262892990635 2.063508300450022 0.0390643599988478 1.0 0.1028554565669746 33 Q05655,Q99805,P06280,Q06136,Q8NCC3,Q8NBX0,P50897,P07602,P16278,O15269,Q9NZJ7,Q9NZ01 12 +I kappab phosphorylation 0.6900662251655556 2.0613862347947256 0.0392662070324165 1.0 0.1033013294279965 4 Q13162,O15111,Q96HY6 3 +Cellular response to peptide hormone stimulus 0.4134013552166103 2.0595706894279817 0.0394396006967492 1.0 0.1037145643477609 58 P49815,Q9UQB8,P27695,P09874,O43865,Q9Y4I1,P78527,Q7L576,P43490,Q15043 10 +Protein import into mitochondrial matrix 0.7288756230218105 2.0577408629100233 0.039615015546601 1.0 0.1040467102538001 9 Q99595 1 +Triglyceride biosynthetic process 0.7453947498815175 2.052923070742541 0.0400800391035409 1.0 0.1050943599596148 5 Q8WTV0 1 +Amyloid beta clearance by cellular catabolic process 0.5665122435473284 2.0518482932649444 0.0401844082635576 1.0 0.1053245768755349 2 Q07954 1 +Neurotrophin signaling pathway 0.803411781166798 2.0514053284489155 0.0402274905847974 1.0 0.1053867209991968 6 Q99523,Q7L576,Q9Y4G8 3 +Deoxyribonucleoside triphosphate catabolic process 0.8031776053818995 2.050409512648826 0.0403244856843172 1.0 0.1054513590640169 6 P00813,Q96DE0 2 +Nucleoside triphosphate catabolic process 0.8031776053818995 2.050409512648826 0.0403244856843172 1.0 0.1054513590640169 6 P00813,Q96DE0 2 +Glycoside catabolic process 0.7446918038196794 2.049726208213926 0.0403911560182699 1.0 0.1054513590640169 5 Q9NUJ1,P08236 2 +Nucleobase containing small molecule biosynthetic process 0.7783480688703253 2.0482551956520427 0.0405350006466771 1.0 0.1055903541435573 7 P00813,Q13126 2 +Glycosyl compound biosynthetic process 0.7783480688703253 2.0482551956520427 0.0405350006466771 1.0 0.1055903541435573 7 P00813,Q13126 2 +Response to organic cyclic compound 0.3326663285069255 2.0427444692734653 0.0410777402302151 1.0 0.1068868875533738 164 P30536,P26358,Q9H2U1,Q86X55,P07099,Q14103,Q92542,Q13126,Q00535,O95831,P61586,Q5KU26,P04818,P49721,P17844,P41440,Q15185,P05067,O15118,P27695,P09874,O60828,Q9NUD5,Q9Y4G8,P16278 25 +Cellular monovalent inorganic cation homeostasis 0.5312077553783789 2.026095649868356 0.0427549838041141 1.0 0.1100226716337678 24 Q8N511,Q9HC07,Q9Y487,P50897,O75503,Q9UHD1,Q93050 7 +Tetrapyrrole metabolic process 0.5850632431278103 2.02608747764037 0.0427558211037455 1.0 0.1100226716337678 18 P30536,P30519,P22830 3 +Regulation of ruffle assembly 0.7479354564274887 2.0243016149984907 0.0429391275706221 1.0 0.1104245819909947 8 P07737,Q7L576,P84095,Q8NCA5 4 +Fatty acid derivative biosynthetic process 0.6292843430966817 2.019756534787531 0.0434086476994388 1.0 0.1113725101532314 13 Q8WVX9,Q13085,P50897,Q9UMR5,P35914,Q92947,Q53GQ0,Q9NZ01 8 +B cell proliferation 0.7469267528026514 2.0196417606972967 0.0434205601258192 1.0 0.1113725101532314 8 Q05655,P00813,P14174,Q96QE3 4 +Positive regulation of anion transport 0.795441352956342 2.017454436404291 0.0436481113419695 1.0 0.1118327100324259 6 P14174 1 +Regulation of neuron differentiation 0.5628340844862869 2.0174098352652923 0.0436527617354387 1.0 0.1118327100324259 20 P61586,Q8WUJ1 2 +Positive regulation of mitophagy in response to mitochondrial depolarization 0.680794701986749 2.016044782448687 0.0437952931982081 1.0 0.1121526525253066 4 Q709C8,Q16543,Q7Z6Z7 3 +Nadh oxidation 0.560225016545343 2.0151113890366883 0.0438929791758488 1.0 0.1123403553828003 2 Q16822 1 +Negative regulation of vascular associated smooth muscle cell proliferation 0.7947399118920649 2.0144609496371393 0.0439611608063461 1.0 0.1124415042596121 6 P61586,P09493 2 +Negative regulation of smooth muscle cell migration 0.7937494034818091 2.010232289591784 0.0444066094260158 1.0 0.1132618015697257 6 P61586,P09493 2 +Membrane depolarization 0.6910692018745638 2.004789700238903 0.0449855341162641 1.0 0.1145545091518329 10 P30536,P09874,Q13557,P63244 4 +Positive regulation of pinocytosis 0.6782902158024046 2.0037602588474064 0.0450957478241014 1.0 0.114585862311606 4 Q06481,P50897 2 +Regulation of pinocytosis 0.6782902158024046 2.0037602588474064 0.0450957478241014 1.0 0.114585862311606 4 Q06481,P50897 2 +Isopentenyl diphosphate biosynthetic process 0.557908669755138 2.001540890735546 0.0453341317249536 1.0 0.1150274416142934 2 Q13907 1 +Carboxylic acid transport 0.5080376399287303 2.000514224344088 0.0454447655036374 1.0 0.11526214267403 28 P14174,P07602,P41440,Q9Y619,Q9H2D1,Q9UBX3 6 +Regulation of viral transcription 0.7337206669728843 1.9996947470404416 0.0455332357642177 1.0 0.1153944364104338 5 P19474 1 +Inflammatory response 0.4041360319950935 1.9980766386449065 0.0457083520172711 1.0 0.115792062742836 63 P60900,Q05655,Q9Y6K9,P49327,Q6P1A2,P14174,Q8IV08,Q9BQE5,Q96KB5,P00813,P42785,P09601,Q06481,P09429,P53634,P30044,O15111,P05067 18 +Leukocyte differentiation 0.4084265571596882 1.991586537869912 0.0464164416466388 1.0 0.1171655691445736 56 P09874,O96005,P49327,Q5JVF3,Q13769,P43034,P00813,P61586,Q04760,P24390,O14617,P78527,P09429,P35579,Q14739,P05067,Q6IBW4 17 +Neuron apoptotic process 0.4352786550755414 1.990172580734299 0.0465719276498601 1.0 0.1174336619059457 49 Q96A26,O95831,P09874,P61586,P05067,Q99720,P50897,P09601,P31751,Q92542,Q00535 11 +Phospholipid dephosphorylation 0.7312890862935444 1.9885714699085504 0.0467485230726179 1.0 0.1176743818747874 5 Q9Y217,Q01968,Q10713 3 +Regulation of cardiac muscle cell membrane repolarization 0.6751655629138961 1.9884121629711191 0.046766124703542 1.0 0.1176743818747874 4 P21333,O75083,O75844 3 +Fatty acid alpha oxidation 0.6143661039390944 1.9867236888200417 0.0469530252052288 1.0 0.1180979138125977 3 O43808,A1L0T0 2 +Regulation of lipoprotein metabolic process 0.6141447938497091 1.985538639531919 0.0470845755942987 1.0 0.1183351373971384 3 Q9H2M9 1 +Regulation of protein lipidation 0.6141447938497091 1.985538639531919 0.0470845755942987 1.0 0.1183351373971384 3 Q9H2M9 1 +Membrane organization 0.3043516978326864 1.9848935871819129 0.047156312021318 1.0 0.1184685846669951 206 P30536,Q9UQB8,O14976,Q6P1A2,Q9BUR5,Q14849,O43681,O60220,Q13505,Q9UHD1,Q9Y584,Q9NS69,P55735,P61586,Q15392,P41440,O15118,P50897,Q06481,Q9Y5J9,P61916,Q9UH99,O75844,Q86XL3,O75531,P45880,P46379,P50542,P08183,Q9Y5L4 30 +Walking behavior 0.6737979693320848 1.981687098612805 0.04751427204898 1.0 0.1192735833899357 4 O15118 1 +Iron ion homeostasis 0.5774685872934636 1.977665629507872 0.047966440109036 1.0 0.1201713414793193 18 Q8N511,Q9Y487,P09601,P30519,Q15043 5 +Response to ether 0.6718503480327381 1.9721018952499976 0.0485979756632624 1.0 0.1214185272467358 4 Q9H4A6,Q14103 2 +Nucleoside phosphate catabolic process 0.5663639810997357 1.9709737822961009 0.0487268747260489 1.0 0.1216449394182118 19 P49773,P00813,Q96DE0 3 +Biological process involved in interaction with host 0.4372193906898846 1.9702485637315632 0.0488098902470799 1.0 0.1218043433099489 48 Q8WTV0,O15118,Q14108,P19474 4 +Antigen processing and presentation of exogenous antigen 0.7596086241629663 1.9650400525398912 0.0494096020226777 1.0 0.1232041704417966 7 Q99538,P04439,Q9UIQ6 3 +Response to wounding 0.3943943511416212 1.9635362352501509 0.0495838983663019 1.0 0.1234934396615263 69 P30536,P49257,Q8WTV0,P61586,P42785,P09601,O14965,P10586,P09493 9 +Phospholipid biosynthetic process 0.436432184064927 1.9623344216614256 0.0497235621914469 1.0 0.1237443074740942 48 Q01968,Q6P1A2,Q9HCL2,Q99570,P35790,O15269,Q99943,Q9NPH0,Q96N66,Q9UHD1,Q86YN1,Q6UWP7,Q10713,O14735 14 +Male meiotic nuclear division 0.7254536787480936 1.9618266962047528 0.0497826644701238 1.0 0.1238429022982805 5 Q9Y2W6 1 +Ruffle organization 0.6107934555433787 1.95993264237163 0.0500036637029708 1.0 0.1243440088012842 14 P07737,Q8NCA5,Q7L576,P84095,O95429,P09493 6 +Synaptic transmission dopaminergic 0.7249320085948161 1.959432317830779 0.0500621789840487 1.0 0.124425214485459 5 Q00535,P41440 2 +Neuron intrinsic apoptotic signaling pathway in response to oxidative stress 0.6692558447602612 1.959318728448016 0.0500754717831661 1.0 0.124425214485459 4 P09874,Q99497 2 +Regulation of metal ion transport 0.439774499905249 1.9583656327094707 0.0501871244394658 1.0 0.1246052198973612 47 P30536,P27695,Q13557,O43865,Q13555,P61586,Q9UHD1,Q00535,P21796 9 +Thrombin activated receptor signaling pathway 0.6086759068624095 1.956208981966001 0.0504405408709427 1.0 0.1251366423792787 3 Q13576 1 +Negative regulation of phosphatidylinositol 3 kinase signaling 0.7238870745620475 1.9546345432161336 0.0506262210901731 1.0 0.1255482876508546 5 P49815 1 +Mitochondrial depolarization 0.7794101425246891 1.9488147075693052 0.0513175567091082 1.0 0.1270149495494905 6 P30536 1 +Cellular iron ion homeostasis 0.5996430431098816 1.943646585737704 0.0519380839494527 1.0 0.1284507632617594 15 P09601,Q8N511,Q9Y487,Q15043 4 +Response to acidic ph 0.6062187105518997 1.943002774458351 0.0520158230945055 1.0 0.1285929877824494 3 Q9UHD1 1 +Regulation of cell population proliferation 0.2972922063518532 1.9424474901323356 0.0520829509099236 1.0 0.1287088786871985 212 P30536,P26358,Q9HCL2,P63167,Q8WUW1,Q86X55,Q9NR77,P55209,P09601,Q96DY7,P43307,P49815,P14174,P98175,Q9NNW5,P00813,P61586,Q15392,P05067,P09493,Q00839,P04439,O75569,Q8NCA5,Q9NPI1,P78527,Q06481,P31751,Q9UKA9,P43490,Q9Y4G8,O75844,Q96QE3,Q969H8,Q92766,P09429,O95747 37 +Myeloid leukocyte cytokine production 0.7544010186300707 1.941793245721761 0.052162134884184 1.0 0.1287422598243698 7 P09601,P14174 2 +Regulation of low density lipoprotein particle clearance 0.7210764735822774 1.941718535417973 0.0521711835624305 1.0 0.1287422598243698 5 Q9Y2B0 1 +Negative regulation of smoothened signaling pathway 0.6059736769468477 1.941684885821574 0.0521752595250437 1.0 0.1287422598243698 3 P63244 1 +Response to molecule of bacterial origin 0.4693557773032055 1.941332249748646 0.0522179902182544 1.0 0.1287422598243698 36 P30536,O43823,P14174,Q8WTV0,P61586 5 +Cardiac ventricle development 0.6230327069121094 1.940694085884249 0.0522953941615766 1.0 0.1288161444512545 12 O96028,P43243,P49840,Q96T37,P09493,O75844 6 +Negative regulation of interleukin 6 production 0.6054286660046343 1.9387529797583396 0.0525314240981191 1.0 0.1293138039295633 3 P04062,Q86UT6 2 +Response to peptide hormone 0.3604610989022088 1.9385879265586996 0.0525515348568379 1.0 0.1293138039295633 81 P49815,Q9UQB8,P27695,P09874,O43865,Q9Y4I1,Q99523,P78527,Q06481,Q7L576,P43490,Q15043 12 +Cellular response to exogenous dsrna 0.7532287738901801 1.936553143219381 0.0527999904074345 1.0 0.129874899005284 7 O60828,Q5KU26,Q9NUD5,P41440 4 +Positive regulation of golgi to plasma membrane protein transport 0.6049806282874632 1.9363421052087593 0.0528258151285045 1.0 0.1298881551090039 3 P63244 1 +Response to increased oxygen levels 0.6496504713642933 1.9322487955761996 0.0533288051035143 1.0 0.1309223195202538 11 P00846,Q8N511,Q96NT0,Q9Y487 4 +Regulation of lipid biosynthetic process 0.5055616737411109 1.9309579412976363 0.0534882538544931 1.0 0.1312124050556382 26 P30536,Q05655,Q6P1A2,Q8WTV0,Q9UHD1,Q9UBM7 6 +Chemokine production 0.7275830085613058 1.929865996364272 0.0536234436016127 1.0 0.1314425790712883 8 P09601,P05067,P14174 3 +Regulation of steroid biosynthetic process 0.6761135347392215 1.928831141041496 0.0537518284948252 1.0 0.1317064849318078 10 P30536 1 +Negative regulation of cytokine production 0.5050373554839058 1.9269535944473184 0.0539854134293054 1.0 0.1322278565536282 26 P30536,P09601,O43823,O75531 4 +Negative regulation of oxidative stress induced neuron death 0.6625827814569456 1.926365734895892 0.0540587227688353 1.0 0.1323564106004305 4 Q15233,Q99497,P63244 3 +Digestive system process 0.6203616225359846 1.9256390488424444 0.0541494593545175 1.0 0.1325275177733205 12 Q8WTV0 1 +Regulation of bone resorption 0.5446724023825374 1.9236301535835616 0.0544009586417555 1.0 0.1329894204334608 2 P41240 1 +Regulation of bone remodeling 0.5446724023825374 1.9236301535835616 0.0544009586417555 1.0 0.1329894204334608 2 P41240 1 +Positive regulation of extracellular matrix disassembly 0.5443414956982225 1.9216745198000904 0.05464672533365 1.0 0.1334875427443041 2 Q16658 1 +Long chain fatty acid transport 0.6195946274044527 1.921312203314537 0.0546923595773116 1.0 0.1335476901549723 12 P14174 1 +Blood vessel endothelial cell migration 0.5484236035352494 1.920539584184359 0.054789778140567 1.0 0.1335988032396524 20 Q8WTV0,P42785,P61586 3 +Negative regulation of hormone secretion 0.7164624047697996 1.9204794264432044 0.0547973694219279 1.0 0.1335988032396524 5 Q16836,Q06124,P40939,P17858 4 +Negative regulation of peptide secretion 0.7164624047697996 1.9204794264432044 0.0547973694219279 1.0 0.1335988032396524 5 Q16836,Q06124,P40939,P17858 4 +Regulation of glucan biosynthetic process 0.6609271523178722 1.9181733664009224 0.0550890321436106 1.0 0.1340527903157691 4 P49840,P62140,P31751 3 +Regulation of glycogen metabolic process 0.6609271523178722 1.9181733664009224 0.0550890321436106 1.0 0.1340527903157691 4 P49840,P62140,P31751 3 +Lipoprotein localization 0.7157876843817976 1.9173699483641096 0.0551909492526803 1.0 0.1342493966513724 5 A6NIH7 1 +Cellular response to insulin stimulus 0.4318190405058961 1.9158688863175577 0.0553817867125827 1.0 0.1345076944383553 48 P49815,Q9UQB8,P09874,Q9Y4I1,P78527,Q7L576,P43490,Q15043 8 +Negative regulation of innate immune response 0.6084763341702405 1.900443852356182 0.0573748967196432 1.0 0.1389237499238295 13 Q14166,P19474,O75531 3 +Response to auditory stimulus 0.5407015221707573 1.9001375971626704 0.0574150648923517 1.0 0.1389680702421125 2 Q8N2K0 1 +Regulation of response to biotic stimulus 0.3937339560525359 1.8983092998329951 0.0576553496111604 1.0 0.1393276202375925 65 P04439,P14174,O75531,P78527,Q9NZ08,Q15366,Q06481,Q14166,P19474,O60828,Q9NUD5,O75844 12 +Regulation of dna demethylation 0.5978152929493575 1.8977078155773113 0.057734582446776 1.0 0.1393276202375925 3 Q13263,Q93009 2 +Brainstem development 0.5400397088021273 1.8962169001381268 0.0579313693420704 1.0 0.1396858055911227 2 P22102 1 +Cellular response to inorganic substance 0.4569321531739549 1.8903706101589843 0.0587084112262394 1.0 0.1411845106901166 39 P30536,O95831,P09874,Q13557,P05067,Q14103,P09601,Q99538,O15111,Q92542 10 +Small rna loading onto risc 0.7656205643902533 1.889403380283376 0.0588377983031587 1.0 0.1414421505351273 6 Q5KU26,O75569 2 +Regulation of neuron projection regeneration 0.5957641772253373 1.8866217791310904 0.0592112152885475 1.0 0.1421784980634712 3 P10586 1 +Response to caffeine 0.5383851753805522 1.8864086097739672 0.0592399132421277 1.0 0.1421936890358625 2 P28161 1 +Positive regulation of muscle contraction 0.7647122871160663 1.885478387101188 0.0593652797224577 1.0 0.1424408146153044 6 P00813 1 +Small molecule biosynthetic process 0.3298647691717664 1.8836531750336292 0.0596119040827816 1.0 0.142897524516052 130 Q9BZF3,Q6P1A2,Q14849,Q15125,P35270,O15269,Q13126,Q15043,P14174,P00813,Q15392,O15382,Q15800,P55263,Q15185,P32929,P48449,Q16850,Q96PU8,Q9UBX3,O14880,Q14739 22 +Organic acid transmembrane transport 0.4993680275012379 1.883570684472439 0.0596230703298568 1.0 0.142897524516052 26 O43772,P08183,P41440,Q9Y619,Q9H2D1,Q9UBX3 6 +Maintenance of protein location 0.4933331831115454 1.8768286595868884 0.0605415811018139 1.0 0.1447169197003119 27 P30536,P21333,O15258,P24390,P52789,O75832,Q709C8,Q99497,Q9UH99,Q9H4A6,Q00535,Q00839 12 +Regulation of hexokinase activity 0.593843098311823 1.8762278833114492 0.0606239948376354 1.0 0.1448594402962447 3 P49792,Q9Y6N1 2 +Positive regulation of leukocyte proliferation 0.5963723460248408 1.875208896067372 0.0607639907931014 1.0 0.1451393932660477 14 P04439,P14174,Q9HCL2,P00813,Q96QE3 5 +Cartilage development 0.595383659295006 1.8693771026126096 0.0615703679077999 1.0 0.1467346300794811 14 Q9UPW6,P04818,O75844,Q15043,Q92896 5 +Neuron death 0.3845439880599551 1.868459248898284 0.0616980852025292 1.0 0.1469838941331619 71 O95831,Q9Y6K9,P09874,Q9UMX5,P61586,Q15392,P05067,Q99720,P50897,P09601,P31751,Q9UHD1,Q92542,Q00535 14 +Cellular response to ether 0.5921685518312007 1.8671594481352407 0.0618793246758562 1.0 0.1473604299886632 3 Q9H4A6 1 +Positive regulation of synaptic transmission 0.5602160025535134 1.8668825734083032 0.0619179879469689 1.0 0.1473972776745072 18 P27695,Q92542,P41440,P05067,Q00535 5 +Negative regulation of cell substrate adhesion 0.737317203968881 1.86516897054171 0.0621577234470822 1.0 0.147850919666556 7 P61586,Q9BTW9,P63167 3 +Regulation of cell activation 0.3962704397278193 1.864831519115019 0.0622050237775235 1.0 0.1478590617539042 58 O96028,P04439,O96005,P14174,Q05655,Q5JVF3,Q9HCL2,P00813,P61586,P78527,P09601,P09429,P53634,Q96QE3 14 +Negative regulation of nervous system development 0.5590034532641207 1.859056688849804 0.0630191034960856 1.0 0.1495703591565049 18 P30536,Q9Y4G8,Q06481 3 +Regulation of vascular associated smooth muscle cell differentiation 0.6486014215239345 1.856980212129858 0.0633139693907267 1.0 0.1499901563352438 4 P26358 1 +Vascular associated smooth muscle cell differentiation 0.6486014215239345 1.856980212129858 0.0633139693907267 1.0 0.1499901563352438 4 P26358 1 +Response to peptide 0.3587186832394058 1.85593254668302 0.063463173197009 1.0 0.1502789048731659 91 P49815,Q9UQB8,P27695,P09874,O43865,P08670,Q9Y4I1,Q99523,P78527,Q06481,Q7L576,P43490,P05067,Q15043 14 +Membrane raft organization 0.7112181710650736 1.85331533454926 0.0638371745152952 1.0 0.1509483189059585 8 O15118,P41440 2 +Negative regulation of glucose transmembrane transport 0.647315323063991 1.8505748110618316 0.0642307462562679 1.0 0.1516370016311568 4 Q06481 1 +Cellular response to estrogen stimulus 0.5882158225753055 1.8457228589930996 0.0649324563522162 1.0 0.152716073623207 3 Q8IZL8,Q9H7N4 2 +Negative regulation of cytokine production involved in inflammatory response 0.5881996937178848 1.8456353004092665 0.0649451773133305 1.0 0.152716073623207 3 Q06481 1 +Negative regulation of cell matrix adhesion 0.6461378894530191 1.8447072906834872 0.0650801297495131 1.0 0.1528637489607929 4 P63167 1 +Negative regulation of cell substrate junction organization 0.6461378894530191 1.8447072906834872 0.0650801297495131 1.0 0.1528637489607929 4 P63167 1 +Leukocyte apoptotic process 0.5566978737069023 1.8441622678680625 0.0651594954670959 1.0 0.1529936288100709 18 P00813,P24390,P14174 3 +Epiboly 0.755003352026437 1.843433572689648 0.0652657320820528 1.0 0.1530734291931838 6 P61586,Q92766 2 +Morphogenesis of an epithelial sheet 0.755003352026437 1.843433572689648 0.0652657320820528 1.0 0.1530734291931838 6 P61586,Q92766 2 +Glycerol ether metabolic process 0.7545067673244058 1.84127876497932 0.0655807179433844 1.0 0.1537369041418676 6 Q8WVX9,P43034,P49327,O00116 4 +Cellular response to amyloid beta 0.7544431270342187 1.8410025833216352 0.0656211801348154 1.0 0.1537369041418676 6 P09874,P05067,Q00535 3 +Response to amyloid beta 0.7544431270342187 1.8410025833216352 0.0656211801348154 1.0 0.1537369041418676 6 P09874,P05067,Q00535 3 +Lipopolysaccharide mediated signaling pathway 0.7543284380343049 1.840504846747273 0.0656941533546477 1.0 0.1538511564930513 6 Q8WTV0 1 +Regulation of calcium ion transport 0.4875409502116435 1.8398494216751016 0.0657903473307977 1.0 0.1540196860532413 28 P30536,P27695,Q13555,P61586,Q00535,P21796 6 +Calcium ion transport 0.4124550945127789 1.8370762770717572 0.0661986357264747 1.0 0.1547952571588869 51 P30536,P27695,Q9HC07,Q13555,P61586,O75844,P21796 7 +Bone morphogenesis 0.6982671647434001 1.836304789615124 0.0663125918008717 1.0 0.1549569240758607 5 Q92896 1 +Regulation of fatty acid beta oxidation 0.586169576590402 1.8346087521014256 0.066563680958936 1.0 0.1554293740540035 3 P31751 1 +Maintenance of location 0.3896969073854341 1.8280875101174203 0.0675364191330931 1.0 0.1572133414213884 63 P30536,Q9H6V9,P21333,P27695,Q13557,Q8WTV0,P43034,Q5T280,P24390,O14617,P52789,O75832,Q709C8,Q9UH99,Q9H4A6,Q00535,Q00839 17 +Response to purine containing compound 0.5876961029918015 1.823932716395632 0.0681622448468195 1.0 0.1584635070396434 14 P27695,P05067,Q9Y4G8 3 +Protein lipid complex assembly 0.6418693264888302 1.823409259316836 0.0682414289670008 1.0 0.1585895877565839 4 Q6P1A2,Q9Y5X1 2 +Neuron development 0.3184455437237282 1.823198482390364 0.0682733348528654 1.0 0.1586057442707649 171 P30536,Q9UQB8,O14976,Q9H2U1,Q14108,Q86X55,Q9NR77,O14965,Q9NZJ7,Q00535,P08670,Q13555,P61586,Q7L576,P41440,P05067,P42892,P50897,Q06481,O60828,Q9Y4G8,P10586 22 +Phosphatidic acid metabolic process 0.7501656726309067 1.8224239308345909 0.0683906862211518 1.0 0.1587623088464723 6 O15228,Q9HCL2,Q99943,Q6UWP7,Q9NPH0 5 +Deoxyribose phosphate metabolic process 0.5870961591403425 1.8203788968629533 0.0687013238885567 1.0 0.1594251970192284 14 P00813,P04818,P55263,Q96DE0,Q9H773 5 +Inner cell mass cell differentiation 0.5271343481138419 1.8194678308783745 0.0688400863454083 1.0 0.1596228501514074 2 Q9NVX2 1 +Blastoderm segmentation 0.5832958063108228 1.8189807930169504 0.0689143604217674 1.0 0.1596228501514074 3 Q9Y2W6 1 +Tripartite regional subdivision 0.5832958063108228 1.8189807930169504 0.0689143604217674 1.0 0.1596228501514074 3 Q9Y2W6 1 +Regulation of muscle adaptation 0.6012332009725596 1.817231402682951 0.069181688503729 1.0 0.1600723742736447 12 P09874,Q13555 2 +Intermembrane lipid transfer 0.726420602455063 1.816013476615101 0.0693683048699724 1.0 0.1603873938717879 7 P30536,P61916 2 +Regulation of lymphocyte differentiation 0.5783300085992867 1.8153356719477696 0.0694723402211574 1.0 0.1605111575593154 15 O96005,Q5JVF3,P00813,P61586,P78527,P09429 6 +Negative regulation of establishment of protein localization 0.532579383297797 1.8130935674862343 0.0698173911340234 1.0 0.1612405250260604 20 P49257,Q16836,Q16850,P31689,O95429,P40939,Q99497,Q9UHD1,Q06124,Q9UMY4,Q00535 11 +Lung cell differentiation 0.5821593927800133 1.8127946813271671 0.0698634946040428 1.0 0.1612405250260604 3 P35222 1 +Hindlimb morphogenesis 0.5815716250537349 1.8095937875670645 0.0703588040414109 1.0 0.162264353587521 3 O95747 1 +Embryonic hindlimb morphogenesis 0.5815716250537349 1.8095937875670645 0.0703588040414109 1.0 0.162264353587521 3 O95747 1 +Actin filament based movement 0.4842085197540442 1.8054565662826376 0.0710032663156838 1.0 0.1634540965963371 27 P21333,Q13557,P60660,P05023,Q9Y4I1,P35580,P35579,Q9UH99,P09493 9 +B cell differentiation 0.625860162616758 1.8042232522663235 0.0711963155755421 1.0 0.1637798703576352 11 P00813,Q5JVF3 2 +Deoxyribonucleoside metabolic process 0.637802864001889 1.8030814615394104 0.0713754221433373 1.0 0.1641324830474139 4 P00813 1 +Response to epidermal growth factor 0.5757342894217767 1.7996133943552306 0.071921704623328 1.0 0.1652093800454907 15 Q9UQB8 1 +Positive regulation of cytokine production involved in immune response 0.6993863203681276 1.7976397186513753 0.072234119859452 1.0 0.1656875012005331 8 Q9H2U1,P14174 2 +Gmp metabolic process 0.574763094813927 1.793725736710155 0.072856955317766 1.0 0.1668222794952778 15 P00813 1 +Regulation of protein binding 0.4232315856193032 1.7932779615341208 0.072928489505941 1.0 0.1669187898090605 47 Q05655,P35611,Q13526,P63244,P62826,Q9Y4G8,O14965,P19474,P41440,Q96D46,Q99497,P10586,P05067,Q00535,Q08379 15 +Axon development 0.3774112698309719 1.7930151669801333 0.0729704989275286 1.0 0.1669548204403786 72 P30536,Q9UQB8,P42892,Q7L576,P41440,P05067,P10586 7 +Lymphocyte apoptotic process 0.5743804336696865 1.791405174001332 0.0732282992485222 1.0 0.1673639230577517 15 P24390,P14174 2 +Response to testosterone 0.6740565031038496 1.790817220301556 0.0733226309416796 1.0 0.1675192819070151 9 P30536 1 +Positive regulation of stress fiber assembly 0.6230909264525456 1.7892287720146884 0.0735779797826714 1.0 0.1680422707505065 11 P61586,P09493 2 +Response to nerve growth factor 0.6488553262959792 1.789019116171647 0.073611736983465 1.0 0.168058979980928 10 Q99523,P05067 2 +Fc receptor mediated stimulatory signaling pathway 0.6349103563261245 1.788599780682222 0.0736792932164538 1.0 0.1681528142491133 4 Q06481 1 +Positive regulation of lipid transport 0.7202834914255891 1.7882348598743796 0.0737381243248314 1.0 0.1682118710980493 7 P14174,Q6P1A2 2 +Neuron differentiation 0.2970303243506034 1.7876360599734893 0.0738347437261421 1.0 0.168279627854118 204 P30536,Q9UQB8,O14976,Q9H2U1,Q14108,Q86X55,Q9NR77,O14965,Q9NZJ7,Q00535,Q8WUJ1,O94915,P08670,Q13555,Q9UPW6,P61586,Q7L576,P41440,P05067,P42892,P50897,Q06481,O60828,Q9Y4G8,P50542,P10586 26 +Smooth muscle contraction 0.6734035226276457 1.7875987840053964 0.0738407618132686 1.0 0.168279627854118 9 P00813 1 +Regulation of lymphocyte activation 0.41546654772036 1.787179523992811 0.0739084776414931 1.0 0.1683132511248048 49 O96028,P04439,O96005,P14174,Q5JVF3,Q9HCL2,P00813,P61586,P78527,Q96QE3 10 +Protein maturation 0.3876879099766696 1.7864454419945002 0.0740271634822558 1.0 0.1683422723052657 61 P09874,O00170,Q6P1A2,O75976,P50579,Q14CX7,Q15392,Q5JRX3,Q9BU89,Q99797,P42892,Q99538,P35579,O75503,Q92542,Q10713,O75844,Q92896 18 +Sphingolipid metabolic process 0.4814175415768228 1.7835481889955114 0.0744971109518588 1.0 0.169350370962094 27 Q05655,Q99805,P06280,Q06136,Q8NCC3,P50897,P07602,P16278,O15269,Q9NZJ7,Q9NZ01 11 +Lipid modification 0.407334441081969 1.7828150985358513 0.0746164071443622 1.0 0.1695003158718964 51 Q9Y217,Q6P1A2,Q16836,Q9BWD1,Q92947,Q53H12,O43808,Q06481,P40939,P31751,Q96N66,Q9UKG9,Q8IVS2,Q709F0,Q01968,P50542,P34913,Q15067,O15254,Q10713 20 +Hormone biosynthetic process 0.6719252546179657 1.7803094516047795 0.0750253311699049 1.0 0.1700691590721017 9 P30536,Q14849,Q9UBM7 3 +Motor behavior 0.5761698208921942 1.78013346682589 0.0750541207044124 1.0 0.1700691590721017 3 P04062 1 +Sterol homeostasis 0.6213258270905343 1.7796617037345803 0.0751313414305903 1.0 0.1701834661913157 11 Q8WTV0,O15118 2 +Mitochondrial transmembrane transport 0.4147032663729423 1.779307307092115 0.0751893936448264 1.0 0.1702542878541207 49 P00846,O95831,Q99595,O60830,O43772,Q9H2D1 6 +Cellular response to estradiol stimulus 0.6858886351581919 1.7786686358087562 0.0752941041534087 1.0 0.170430671652089 5 O95831 1 +Localization within membrane 0.317425313978608 1.77282860862768 0.0762571113191055 1.0 0.1722424305416612 167 O14976,Q9HD45,P63244,O43681,O60220,P43307,Q9UHD1,Q9NT62,Q9Y584,Q9NS69,Q9UMY4,Q9NZJ7,Q00535,P21333,Q9Y4I1,P07602,Q9HD20,P84095,P41440,O60725,O15118,Q99805,O43805,Q8IYI6,O15027,O14617,Q4V328,Q96KP1,Q9Y5J9,P31751,O95429,Q9Y4G8,P50542,P46379,Q9H4A6,Q9BTX1,Q96L92,P49458,Q9Y5L4,Q9NV70 40 +Cellular carbohydrate catabolic process 0.5362624424028624 1.7720554570000526 0.0763853519598787 1.0 0.1723820261027417 19 Q9NUJ1 1 +Branching morphogenesis of a nerve 0.5191925876902811 1.7719655374629115 0.0764002780886443 1.0 0.1723820261027417 2 Q9NQC3 1 +B cell activation involved in immune response 0.5628157873981912 1.770658203872615 0.0766175567845914 1.0 0.1728103582886336 16 O96028,P00813,Q9UQ84,Q96FZ2,Q96QE3 5 +Negative regulation of developmental process 0.3510960018351661 1.7703330112660427 0.076671681934227 1.0 0.1728103582886336 95 P30536,Q8N4Q0,P26358,Q86X55,Q99538,Q00535,P14174,P61586,P05067,Q00839,Q99523,Q06481,Q99536,Q9P258,Q9H6W3,Q9Y4G8,P09429,O95747,Q96T37,P16989 20 +Positive regulation of peptidyl serine phosphorylation 0.5622106342630593 1.7669003752043555 0.0772449141882165 1.0 0.1739173484166859 16 P05067,P14174 2 +Regulation of muscle contraction 0.5257842397198362 1.7667274327141205 0.0772738868322973 1.0 0.173920971921417 20 P00813,P61586 2 +Positive regulation of supramolecular fiber organization 0.4381877339746503 1.7637560372506975 0.0777730620684789 1.0 0.1748891500805257 41 Q9UQB8,P61586,O95429,P05067,P09493 5 +Vacuolar transport 0.4355514344329692 1.7636829227257236 0.0777853778623451 1.0 0.1748891500805257 42 O14976,Q96ED9,P11717,Q99523,Q14108,O14617,P07602,Q709C8,P13473,Q96L92,Q99570,Q9NZJ7,Q9Y2T2,O15118 14 +Fc receptor signaling pathway 0.6299074816484027 1.7635091048196383 0.0778146630379108 1.0 0.1748891500805257 4 Q06481 1 +Cellular metabolic compound salvage 0.6679567293436653 1.7607190001262294 0.0782859752578843 1.0 0.1757632139664829 9 P00813,Q13126 2 +Bone development 0.5019880815550268 1.7601469364934406 0.0783828963136785 1.0 0.175856579233936 23 O96028,P61586,Q7RTS9,Q92896,O75844 5 +Myeloid leukocyte differentiation 0.4878013816086951 1.7585426585035682 0.0786552198680841 1.0 0.176405284926444 25 P09874,P49327,Q13769,Q04760,P35579,Q14739,P05067 7 +Establishment of protein localization to mitochondrial membrane 0.552099008388157 1.7567895907818385 0.0789536799897436 1.0 0.1768874127651783 17 Q9Y5L4,Q9NS69,Q9Y5J9,O60220 4 +Membrane invagination 0.6418314744586888 1.752720576508891 0.0796499819628469 1.0 0.1783216926227033 10 P61586,Q06481,P84095,P35579,Q9Y5X1 5 +Fatty acid transmembrane transport 0.7337295213515901 1.7507545054221136 0.0799882062451162 1.0 0.1789528471995631 6 O43772 1 +B cell activation 0.4510009332776867 1.7499155250261 0.0801328913536163 1.0 0.1791504247075573 34 O96028,Q05655,P14174,P17812,Q5JVF3,P00813,Q9UQ84,P78527,P78318,Q96FZ2,Q96QE3 11 +Regulation of macroautophagy 0.4218265990474406 1.7458836602898138 0.080831169705362 1.0 0.1805210522302464 46 P21796,P49815,Q9Y6K9,O00267,Q96KQ7,Q8IYI6,Q9Y487,P09601,O15269,Q9NV70,Q00535,O15118,Q93050 13 +Multi organism reproductive process 0.3216404761594546 1.741753288530962 0.0815516235537425 1.0 0.1820021486332822 140 P25440,P11717,Q6IBW4,Q9H2U1,P43034,Q14141,O14965,P35579,Q96KQ7,Q9BQE5,P00813,P62826,P49368,P55769,P09622,Q08J23,P41440,P05067,O75718,Q99598,Q96PU8,Q9GZP4,Q9Y2W6,P45880,P46379,Q9UIQ6,Q8IWV8,Q96MU7,Q15067,Q96CW5,A0AVF1,Q9BTX1,P16989,O60879 34 +Smooth muscle cell migration 0.686795915905907 1.7381047060687198 0.0821923658349552 1.0 0.1829461625396508 8 P61586,P09493 2 +Cellular response to reactive nitrogen species 0.7292796368576606 1.731276483548818 0.0834024636731722 1.0 0.1852869832599381 6 O95831 1 +Response to nitric oxide 0.7292796368576606 1.731276483548818 0.0834024636731722 1.0 0.1852869832599381 6 O95831 1 +Phospholipid catabolic process 0.6372628023318655 1.7290534613479231 0.0837995273022929 1.0 0.1860390483874864 10 Q8WTV0,Q8NCC3 2 +Inorganic anion transport 0.5038354501012503 1.7264779565805883 0.0842614616809831 1.0 0.1869294078923637 22 P30536,P45880,O43681,P08183,Q9UHG3,Q15043,P21796 7 +Positive regulation of actin filament bundle assembly 0.5853265905565659 1.7263258294624944 0.0842888110477524 1.0 0.1869294078923637 12 P61586,O95429,P09493 3 +Positive regulation of neuron apoptotic process 0.6365228891903575 1.725216366586439 0.0844884872546658 1.0 0.1873068800106927 10 O95831,P61586 2 +Detection of stimulus 0.5706874857818403 1.7227864309259713 0.0849271534636701 1.0 0.1880825740122257 14 P30536 1 +Vascular process in circulatory system 0.4715510039696981 1.7216851167613814 0.0851265748603629 1.0 0.1884585544453036 29 Q9HB40,P61586,P42892,P08183 4 +Lysosomal transport 0.4443695421189931 1.7209588869791732 0.0852582845846396 1.0 0.1886844208983182 36 O14976,Q96ED9,P11717,Q99523,Q14108,O14617,P07602,P13473,Q96L92,Q9NZJ7,Q9Y2T2,O15118 12 +Regulation of protein folding 0.621226876796581 1.7198468281710533 0.085460287900128 1.0 0.1889863647823926 4 Q9UL15,O14737 2 +Monovalent inorganic cation homeostasis 0.4823166447158428 1.7167158347778309 0.0860311054829983 1.0 0.1901299396557501 25 Q8N511,Q9HC07,Q9Y487,P50897,O75503,Q9UHD1,Q93050 7 +Regulation of cellular component movement 0.3203799787490209 1.7160841839887735 0.0861466355568891 1.0 0.1903190877996481 136 P63167,Q8WTV0,P42785,P09601,Q99538,O75131,Q00535,P07737,P14174,P00813,P61586,Q13526,P84095,P05067,P09493,P27695,Q9Y6A4,O95684,Q06481,P31751,O95429,Q9UH99,Q9Y4G8,Q13557,Q92766,P09429,O95747 27 +Regulation of protein kinase a signaling 0.5643917142096875 1.7156366449044336 0.0862285670997851 1.0 0.1903677570289108 3 P14174 1 +Metal ion transport 0.3488749276848433 1.7142656147741324 0.0864799551511672 1.0 0.1907902099759871 91 P30536,P21796,P27695,Q9HC07,O43865,Q13555,P61586,Q9HD20,Q9UHD1,Q15043,O75844 11 +Regulation of hormone levels 0.3814431647055896 1.7132349287623334 0.086669328153315 1.0 0.1910747410705967 61 P30536,Q13555,Q9HB40,P42892,O15382,P40939,Q6NUM9,Q15043,O75844 9 +Rna interference 0.6339802451345878 1.712021909694088 0.0868926308741477 1.0 0.191434856788937 10 Q5KU26,O75569,Q99598 3 +Regulation of transmembrane transport 0.3818153468064624 1.7104491208462465 0.0871828542855328 1.0 0.1919411921852604 60 P27695,Q13557,O43865,Q9BZE9,Q06481,P52789,P31751,P08183,Q9UHD1,P05067,Q00535,O75844,P21796 13 +Positive regulation of lymphocyte differentiation 0.6336338648277969 1.710223422255577 0.087224566083351 1.0 0.1919665311723612 10 P00813,P61586,Q5JVF3 3 +Glycerophospholipid catabolic process 0.7242672814666367 1.7092997438887452 0.0873954407430381 1.0 0.1922094883608133 6 Q8WTV0 1 +Cysteine metabolic process 0.6184221469936344 1.7057058895381765 0.0880628525682534 1.0 0.1936103393026007 4 P32929 1 +Glycerolipid metabolic process 0.3830668112838811 1.7047204552216269 0.0882465730014578 1.0 0.193947170815099 56 Q9Y217,Q6P1A2,Q9HCL2,Q8WTV0,P43034,Q8NCC3,P35790,Q9NPH0,Q8WVX9,Q99943,Q53H12,P40939,Q96N66,Q99570,Q06124,Q9UBV2,O15228,Q01968,O00443,Q6UWP7,O14735,Q10713 22 +Regulation of lysosomal lumen ph 0.7230758943169567 1.704070466897841 0.0883679232689376 1.0 0.1941467405106697 6 Q8N511,Q9HC07,O75503,P50897 4 +Fatty acyl coa biosynthetic process 0.6322502763588578 1.7030370693672483 0.0885611314445635 1.0 0.1943025721303576 10 Q13085,P50897,Q9UMR5,Q92947,Q53GQ0,Q9NZ01 6 +Regulation of nervous system development 0.3821711930765228 1.7028600151406594 0.0885942683567095 1.0 0.1943082020963582 58 P30536,Q9UQB8,P27695,Q9H2U1,P55209,Q06481,Q7L576,P53634,Q9Y4G8 9 +Prostate gland development 0.6693348216712884 1.701147462537687 0.0889153003553393 1.0 0.1947435041552504 5 P07602 1 +Regulation of calcium mediated signaling 0.6788035535982753 1.700163637158516 0.0891001499504782 1.0 0.1950811412625696 8 P49773,P00813 2 +Negative regulation of locomotion 0.4400852658192055 1.6992560615795809 0.0892709474721977 1.0 0.1953205308548327 37 P27695,P14174,P00813,P61586,Q13526,P09601,P09429,P09493 8 +Sensory perception of mechanical stimulus 0.5588668364871159 1.696974681220394 0.0897014473792645 1.0 0.1961949069313852 15 Q14108,Q9Y5J9 2 +Tetrapyrrole biosynthetic process 0.5734308781074617 1.6966617812635862 0.0897606221992142 1.0 0.1962349346097377 13 P30536 1 +Regulation of dna damage response signal transduction by p53 class mediator 0.6549713049672655 1.696402409161926 0.0898096977907685 1.0 0.1962349346097377 9 P17844,P14174,O75844 3 +Response to alcohol 0.4333955069843944 1.696388288517196 0.0898123701667286 1.0 0.1962349346097377 40 P30536,P09874,O95831,O43823,P61586,Q14103,P16278 7 +Organic anion transport 0.4396505046681006 1.69534910640079 0.090009214389477 1.0 0.1965556432882412 37 P14174,Q8TB61,P07602,P41440,Q9Y619,Q9H2D1,Q9UBX3 7 +Cell recognition 0.4988375846030004 1.6905719410607454 0.0909185874147573 1.0 0.198243067447066 22 Q8WTV0,P05067,P45880 3 +Lymphocyte homeostasis 0.6985363025665232 1.689282034598969 0.0911653945366106 1.0 0.1985088207176078 7 P49327,P00813,P14174,Q9HCL2 4 +Dna damage response signal transduction by p53 class mediator 0.5718657206014031 1.6874844662241737 0.091510234358239 1.0 0.1991232624378525 13 P17844,P14174,O75844 3 +Regulation of neurogenesis 0.3857537940124185 1.6829481946602507 0.0923851206249015 1.0 0.2006834677689249 54 P30536,Q9UQB8,P27695,Q9H2U1,P55209,Q06481,Q7L576,Q9Y4G8 8 +Regulation of peptidyl serine phosphorylation 0.5228796656959684 1.682608068796828 0.092450988659954 1.0 0.2007116782281973 19 P05067,P14174 2 +Regulation of endothelial cell migration 0.4847657136868987 1.6825550271963186 0.0924612639792576 1.0 0.2007116782281973 24 Q8WTV0,P42785,P61586 3 +Regulation of necrotic cell death 0.5776694362228375 1.682336811712163 0.092503546743955 1.0 0.2007349071712454 12 P30536,P16989 2 +Mitotic nuclear membrane organization 0.6135274298068457 1.6809894989285028 0.0927649542874187 1.0 0.2011648070456613 4 O75531 1 +Establishment of protein localization to membrane 0.3432000614453047 1.678812893735136 0.0931885149240341 1.0 0.2016761114449968 83 Q9UHD1,Q9Y584,P50542,P46379,Q4V328,O43681,Q9Y5J9,Q9HD20,O60220,P43307,P31751,O60725,Q9Y5L4,Q9NS69,Q00535,O15118 16 +Lactation 0.6027975346637697 1.6787995469485526 0.0931911169468149 1.0 0.2016761114449968 11 P00403,Q13505 2 +Steroid hormone biosynthetic process 0.6961060393950547 1.678176001083869 0.0933127453347242 1.0 0.2018705954212073 7 P30536 1 +Gland development 0.373173116925749 1.6743619749964518 0.0940594811863122 1.0 0.2033476402789798 67 P30536,P00403,P11717,P00813,P04818,Q92766,Q14103,P09601,P07602,P31751,O14965,Q13505,Q9NZJ7,O75844 14 +Peptidyl arginine modification 0.6940875417006029 1.668944676043611 0.0951283445043877 1.0 0.2052395647216187 7 Q99873,Q86X55,Q9ULX3 3 +Negative regulation of multicellular organismal process 0.3431191702133596 1.6669950474285944 0.0955153896646301 1.0 0.2059348089241482 97 P30536,O43823,O75531,P00813,P61586,Q16850,Q9UIQ6,Q06481,P09601,P53634,Q92945,P16989,Q9Y4G8 13 +Neuron maturation 0.7141271727017224 1.664725073089203 0.0959676183371072 1.0 0.2066003487615053 6 Q9NZJ7,P05067 2 +Sulfur amino acid biosynthetic process 0.6603691528158543 1.658960765980247 0.0971236984839636 1.0 0.2086944650318028 5 Q13126 1 +Cholesterol efflux 0.6696596975413424 1.656621721270269 0.0975959780086315 1.0 0.2095444826807386 8 Q8WTV0,O15118 2 +Peptidyl arginine n methylation 0.6594437775897763 1.6545988847264992 0.0980058899016271 1.0 0.2100928958565741 5 Q86X55 1 +Peptidyl arginine methylation 0.6594437775897763 1.6545988847264992 0.0980058899016271 1.0 0.2100928958565741 5 Q86X55 1 +Negative regulation of cell development 0.4938007112575924 1.6542971199652308 0.0980671578802789 1.0 0.2101533565364306 22 P30536,Q9Y4G8,Q06481 3 +Response to vitamin a 0.553053555401635 1.653226566790173 0.0982847615529227 1.0 0.2105486836637604 3 P04818 1 +Negative regulation of nuclease activity 0.4993381866313808 1.6523591889049558 0.0984613498978013 1.0 0.2106869196607255 2 P61221 1 +Positive regulation of lipid metabolic process 0.5515578076448391 1.6522584214970653 0.0984818814210219 1.0 0.2106869196607255 15 Q8WTV0,Q9UHD1,Q05655,P31751 4 +Adult behavior 0.5088254223439898 1.650318895242428 0.0988777296291534 1.0 0.2113914730988561 20 O15020,Q96KQ7,P43034,P05067,P50897,Q92542,Q00535,O15118,O75844 9 +Regulation of dendrite development 0.526755829950629 1.6491553187049588 0.0991158190321765 1.0 0.2118292352953982 18 Q9UQB8,Q9H2U1,P61586,Q7L576,O60828,Q9Y4G8 6 +Protein targeting to vacuole 0.5580549717522828 1.6471633718653065 0.0995244702680615 1.0 0.2124882542908294 14 Q99523,Q14108,O14617,P13473,Q99570,Q9Y2T2 6 +Positive regulation of macrophage activation 0.5518471885709875 1.646568493713883 0.0996467708216741 1.0 0.2126065375436593 3 P53634 1 +Microglial cell activation 0.5510733621970936 1.6422959211223904 0.1005286920188588 1.0 0.2142761470253835 3 P05067 1 +Digestion 0.5641722861676222 1.6422874872609157 0.1005304390229222 1.0 0.2142761470253835 13 Q8WTV0 1 +Histone h2a k63 linked ubiquitination 0.5508109897384966 1.6408469620742476 0.1008291870073025 1.0 0.2147688715209166 3 O95071,Q96FW1 2 +Neuron cellular homeostasis 0.6052980132450216 1.6393283280063646 0.1011448993964796 1.0 0.2152408102924762 4 Q14203,P51790,Q00535 3 +Response to chemokine 0.7080762043193758 1.6380549558288209 0.1014102302446562 1.0 0.21571734385376 6 P61586,O95747 2 +Positive regulation of signaling 0.2776053804136116 1.6373717982389442 0.1015528071715996 1.0 0.2159332064258082 233 Q9UQB8,Q8TB61,Q9UMX5,Q9H2U1,P09601,P49773,Q92542,Q00535,Q15043,P55735,P61927,P25398,Q9Y6K9,P14174,Q5JVF3,P00813,P61586,Q13526,P57088,Q7L576,P17844,P19474,P41440,P05067,P27695,P09874,O75569,P42892,Q06481,Q9NUD5,O95429,Q9Y4G8,P53634 33 +Regulation of alpha beta t cell activation 0.5952037323610435 1.6372432422600978 0.1015796550052181 1.0 0.2159332064258082 11 P09429,P04439,P61586,P00813 4 +Positive regulation of myeloid leukocyte cytokine production involved in immune response 0.7071362665512954 1.6339075122210291 0.1022782721357677 1.0 0.2170553247729349 6 P14174 1 +Regulation of epithelial cell migration 0.4361909328577199 1.633585205812622 0.1023459763037684 1.0 0.2170725227080576 35 P07737,Q8WTV0,P61586,Q92766,P42785,P09601,P09429 7 +Deoxyribose phosphate catabolic process 0.6858996256688386 1.631434676856388 0.1027986328812888 1.0 0.2178686597510744 7 P00813,Q96DE0 2 +Positive regulation of cytoskeleton organization 0.4187013144292572 1.6285946339437394 0.1033988609856693 1.0 0.2189217722934424 43 Q9UQB8,P61586,Q7L576,Q00535,O95429,P09493 6 +Regulation of actin filament length 0.415937974070248 1.6284114743538365 0.1034376662299649 1.0 0.2189310045147044 44 Q9UQB8,P07737,Q9UEY8,O15143,Q05655,O15020,Q8WUW1,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,Q9Y5X1 14 +Regulation of extracellular matrix disassembly 0.5484015395849 1.6275335092260392 0.1036238377423488 1.0 0.2191837258244478 3 Q07954 1 +Negative regulation of intracellular protein transport 0.663518681606399 1.627301971879123 0.1036729793256208 1.0 0.2192100654004144 8 Q9UHD1,O95429,P49257 3 +Cellular response to increased oxygen levels 0.663027347845472 1.6249535597746945 0.1041724545261733 1.0 0.2201197210666082 8 Q8N511,Q96NT0,Q9Y487 3 +Negative regulation of autophagy 0.4657712060875715 1.6235192337998043 0.1044784551575865 1.0 0.2205463503758287 26 P30536,P09601,P10619,O15118 4 +Pancreatic juice secretion 0.494374586366655 1.622280177521158 0.1047433710339187 1.0 0.2210221992325209 2 Q9H4A3 1 +Rna secondary structure unwinding 0.6019100735476824 1.6221397694726725 0.1047734245260518 1.0 0.2210221992325209 4 Q9H2U1 1 +Intestinal absorption 0.6398822305245712 1.6212765888147147 0.1049583335598829 1.0 0.2213388082636416 9 Q8WTV0 1 +Relaxation of muscle 0.6016556291390622 1.6208480053938212 0.1050502401351214 1.0 0.2214591463677717 4 Q13557,P30626,P05023 3 +Embryonic hemopoiesis 0.6015840979187579 1.620484834263363 0.1051281695119334 1.0 0.2215499487459712 4 Q13769 1 +Inorganic anion transmembrane transport 0.6833800716718903 1.61987223272838 0.1052597257113943 1.0 0.2217536680880418 7 Q9UHG3 1 +Carbohydrate transport 0.5459379554492124 1.6177846089118704 0.105709024437991 1.0 0.2225527963427582 15 L0R6Q1,Q99523,Q9BZE9,Q06481,P31751 5 +Response to hyperoxia 0.650405981362743 1.6119255876558478 0.1069781333641208 1.0 0.2250009979028299 5 P00846 1 +Fat cell differentiation 0.4683361326709886 1.609567698254286 0.1074922647355995 1.0 0.2258581271601557 25 Q8N4Q0,Q99523,Q86X55,Q9NZ08,P31751,Q00839 6 +Leukocyte homeostasis 0.6374555102971513 1.6091577367002434 0.1075818551081471 1.0 0.2259716692225324 9 P49327,P14174,Q9HCL2,P00813,P09429 5 +Positive regulation of autophagy 0.4744018298566741 1.6046975651023268 0.1085603780576787 1.0 0.2275123935448495 24 P49815,Q9Y6K9,P09601,P09429,O15269,P19474,P21796 7 +Biological process involved in interspecies interaction between organisms 0.2780358068827646 1.604149465449406 0.1086811106812113 1.0 0.2276786880322278 256 P30536,Q9UQB8,P10321,P11717,Q9HCL2,Q8WTV0,Q9H2U1,Q14108,Q9Y6K9,P14174,P08670,P61586,Q5KU26,Q14166,P19474,Q7Z7L1,Q09161,O15118,P04439,O75569,Q13769,P78527,Q9NZ08,Q06481,Q96KP1,Q15366,O15111,O60828,P61916,Q9NUD5,O75844,O43823,P68371,O75531,P62888,P09429 36 +Muscle cell migration 0.6131712278128318 1.603560081842816 0.1088110556259613 1.0 0.2278758054558848 10 P61586,P09493 2 +Golgi to lysosome transport 0.6485188382422538 1.6029990259285525 0.1089348691472968 1.0 0.2280599566206255 5 Q99523 1 +Regulation of lymphocyte migration 0.6793399147103971 1.601312608878158 0.1093076977001827 1.0 0.2287651388153973 7 P61586,P05067 2 +Neuron projection regeneration 0.612435294777691 1.599709468071621 0.1096630504688356 1.0 0.2291461069159681 10 P30536 1 +Gtp metabolic process 0.5631304821844673 1.5984368723626652 0.1099457840965276 1.0 0.2294524420612602 12 P61586,P62826 2 +Organic acid transport 0.4205626006359048 1.5983684423947633 0.1099610035428884 1.0 0.2294524420612602 41 P14174,O43772,P31751,P08183,Q6P4A7,Q9Y619,P41440,Q9H2D1,Q9UBX3,Q9UKG9 10 +Regulation of innate immune response 0.4067913148143303 1.5960136474379214 0.1104857463882487 1.0 0.2302666211442482 46 P04439,O75531,P78527,Q9NZ08,Q06481,Q14166,P19474,O60828,Q9NUD5 9 +Regulation of brown fat cell differentiation 0.5419263810504801 1.591692173765668 0.1114538876871342 1.0 0.2320343629673846 3 Q00839 1 +Deoxyribonucleoside monophosphate metabolic process 0.6338960720098397 1.5913647702365292 0.1115275079765956 1.0 0.2321116046821354 9 P00813,P04818,P55263,P32321 4 +Transition metal ion transport 0.5483583206682368 1.5888523342669405 0.112093734667898 1.0 0.2330610983150671 14 Q9HD20,Q15043 2 +Cerebral cortex cell migration 0.609504330647179 1.5843644741719465 0.1131108014707886 1.0 0.2348684267064138 10 P50542,P43034,P61586,Q96N66,Q00535 5 +Ruffle assembly 0.5854313393893089 1.583593706950126 0.1132862069321027 1.0 0.2350790503625352 11 P07737,Q8NCA5,Q7L576,P84095,O95429 5 +Regulation of inflammatory response 0.4478649577242711 1.5826121864103837 0.1135098841851647 1.0 0.235389502081862 30 P60900,Q05655,Q6P1A2,Q96KB5,P00813,P53634,P05067 7 +Liposaccharide metabolic process 0.5460851714894448 1.57515204579753 0.1152213530786625 1.0 0.2383941797421807 14 Q99805,Q8NBX0 2 +Germ cell development 0.4322784779270466 1.5748914990115794 0.1152814912220403 1.0 0.2384409886779331 33 Q9Y2W6,Q96KQ7,P43034,P62826,Q96MU7,Q96PU8,P09622,Q08J23,A0AVF1,O14965,Q9GZP4,O60879 12 +Insulin like growth factor receptor signaling pathway 0.5925811991087702 1.5747036703496458 0.1153248602310432 1.0 0.2384530942187739 4 P49815 1 +Establishment of protein localization to vacuole 0.5313389772019089 1.573844886637232 0.1155233139742224 1.0 0.2387639331475827 16 Q99523,Q14108,O14617,P13473,Q99570,Q9Y2T2 6 +Positive regulation of sodium ion transport 0.6931592066017129 1.5720950266487648 0.1159285147351665 1.0 0.2393897464771665 6 O43865 1 +Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.5379285741401825 1.5695195236826558 0.1165269338837236 1.0 0.2405473178840361 3 Q99497 1 +Positive regulation of neuron differentiation 0.6059997866075848 1.5659973455956588 0.1173492385759544 1.0 0.2420875561144974 10 Q8WUJ1 1 +Regulation of biological process involved in symbiotic interaction 0.6710905940074167 1.5633469687146817 0.1179710063812378 1.0 0.2431047459092138 7 P19474 1 +Tumor necrosis factor superfamily cytokine production 0.5051455238775673 1.5632436267060963 0.1179953022545508 1.0 0.2431047459092138 19 P30536,P05067,P14174 3 +Actin polymerization or depolymerization 0.3936063720256715 1.5604588093651652 0.1186514966386651 1.0 0.2442192074596359 49 Q9UQB8,P07737,Q9UEY8,O15143,Q05655,O15020,Q8WUW1,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,Q9Y5X1 14 +Fatty acid catabolic process 0.4140595076186941 1.5595151196134136 0.1188745088423892 1.0 0.244519863495866 42 P50542,Q9BWD1,Q8NCC3,P40939,O15254,Q9UKG9 6 +Actin filament polymerization 0.4139928173368051 1.5588784679026269 0.1190251475178971 1.0 0.2446403314329462 42 Q9UQB8,P07737,Q9UEY8,O15143,Q05655,O15020,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,Q9Y5X1 13 +Response to xenobiotic stimulus 0.3626442900212557 1.5573150396271689 0.1193957063959414 1.0 0.2450335008539089 68 P30536,O43169,P27695,O00170,P61586,P07099,P09601,P40939,P08183,O15118 10 +Dtmp metabolic process 0.5891383360671215 1.5571594703735687 0.1194326283268423 1.0 0.2450335008539089 4 P04818,P32321 2 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.5891383360671215 1.5571594703735687 0.1194326283268423 1.0 0.2450335008539089 4 P04818,P32321 2 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.5891383360671215 1.5571594703735687 0.1194326283268423 1.0 0.2450335008539089 4 P04818,P32321 2 +Positive regulation of carbohydrate metabolic process 0.6383663197646225 1.5548849891920389 0.1199734629891686 1.0 0.245984300244889 5 P05067 1 +Antigen processing and presentation of peptide antigen 0.5797841376402038 1.5525091778716509 0.1205404383984616 1.0 0.2469078396585955 11 Q9UIQ6,P04439,Q9NZ08,P10321 4 +Phosphatidylglycerol metabolic process 0.5786559700544297 1.5462924917854437 0.1220339444499098 1.0 0.2496452368598736 11 P40939,Q6UWP7,Q8NCC3 3 +Positive regulation of mononuclear cell migration 0.6242698318471185 1.5431459740091458 0.1227953621705479 1.0 0.2508798849103191 9 P09429,P61586,P05067,O95747 4 +Smooth muscle cell proliferation 0.5020466987970009 1.5422993788297226 0.1230008598402916 1.0 0.2511509226596777 19 P09601,P61586,P09493,P26358 4 +Regulation of ubiquitin specific protease activity 0.5329998017048949 1.5421396344971738 0.1230396653702463 1.0 0.2511509226596777 3 Q99497 1 +Alcohol catabolic process 0.5778974036226566 1.5421112321484007 0.1230465659474884 1.0 0.2511509226596777 11 Q8WTV0,P30837 2 +Negative regulation of golgi to plasma membrane protein transport 0.4811383189940549 1.541756990837845 0.1231326570960171 1.0 0.2512459609959181 2 P41240 1 +Regulation of leukocyte apoptotic process 0.6010458542188074 1.539999782317879 0.1235604064847541 1.0 0.2520378509682598 10 P00813,P14174,Q9Y4G8 3 +Heparan sulfate proteoglycan biosynthetic process 0.63426255520625 1.535395379284528 0.1246867380559306 1.0 0.2538705943569389 5 Q99805 1 +Heparan sulfate proteoglycan metabolic process 0.63426255520625 1.535395379284528 0.1246867380559306 1.0 0.2538705943569389 5 Q99805 1 +Cell cycle dna replication 0.5173119960344078 1.533921699675459 0.1250489168662942 1.0 0.2543394929926932 17 Q96QE3,P33991,O75312,P12004,Q14566,P49736,P46100,O95785,P09884,O75419,O75844 11 +Cellular response to dsrna 0.6220850300957814 1.5321829451502829 0.1254772959236256 1.0 0.2551291404000527 9 O60828,Q5KU26,Q9NUD5,P41440 4 +Negative regulation of immune response 0.4823908402968951 1.530947431854775 0.1257823852344863 1.0 0.2554226327637046 21 Q14166,P19474,O75531 3 +Mitotic chromosome condensation 0.5449976357738079 1.5290653728901071 0.1262482384983467 1.0 0.2559778252106989 13 P42695,Q9UIG0,O43823 3 +Positive regulation of endothelial cell chemotaxis 0.5306196133614776 1.5289007623733084 0.126289047236038 1.0 0.2559778252106989 3 Q99538 1 +Regulation of endothelial cell chemotaxis 0.5306196133614776 1.5289007623733084 0.126289047236038 1.0 0.2559778252106989 3 Q99538 1 +Regulation of intracellular lipid transport 0.4788219722038471 1.527621979522835 0.1266064213778008 1.0 0.2559778252106989 2 P22307 1 +Positive regulation of intracellular lipid transport 0.4788219722038471 1.527621979522835 0.1266064213778008 1.0 0.2559778252106989 2 P22307 1 +Cellular ion homeostasis 0.3325672326643692 1.5273695008112784 0.1266691560303543 1.0 0.2559778252106989 83 P27695,Q8N511,Q9HC07,Q13557,Q9Y487,P50897,P09601,P09429,Q9HD20,O75503,Q9UHD1,P05067,Q00535,Q15043,Q93050 15 +Response to steroid hormone 0.3611919675908783 1.527209895445261 0.1267088264591636 1.0 0.2559778252106989 67 P30536,O95831,P09874,P61586,Q86X55,P04818,P17844,P16278,Q15185,O15118 10 +Vasculogenesis 0.6632416307590231 1.527141508576405 0.1267258271956461 1.0 0.2559778252106989 7 O95470,Q9BYW2,Q92990,Q96PU8,Q4VCS5,Q9Y4G8 6 +Deoxyribonucleoside monophosphate biosynthetic process 0.6825980665880793 1.525227118222944 0.1272024588925457 1.0 0.2567478020708228 6 P04183,P04818,P55263,P32321 4 +Sensory perception of light stimulus 0.5307925861408672 1.5245156891838054 0.1273799406723708 1.0 0.256942844466388 15 O75569,O43924,P11047,Q99797,P50897,Q9H6K4,Q9ULX3 7 +Positive regulation of atp metabolic process 0.6318833941322242 1.524085932431029 0.1274872463470164 1.0 0.2569961743677884 5 P05067 1 +Positive regulation of nucleotide metabolic process 0.6318833941322242 1.524085932431029 0.1274872463470164 1.0 0.2569961743677884 5 P05067 1 +Defense response 0.2849835960783217 1.5212412744468269 0.128199301229215 1.0 0.2582677523337214 204 P60900,P10321,Q6P1A2,Q9HCL2,Q9H2U1,P42785,P09601,Q9Y6K9,P14174,P08670,Q9BQE5,P00813,Q5KU26,Q14166,P19474,Q7Z7L1,P05067,Q09161,P04439,P78527,Q9NZ08,Q06481,Q15366,O15111,O60828,Q9NUD5,O75844,Q8IV08,O43823,P68371,O75531,P62888,P09429,P53634,P30044 35 +Positive regulation of neurotransmitter uptake 0.4774983454665898 1.5195394123974757 0.1286267753118894 1.0 0.2588827688037902 2 P05556 1 +Bone mineralization 0.6810863257696383 1.5185077970145104 0.1288864354293133 1.0 0.2592411973382011 6 O75844 1 +Dna strand elongation involved in dna replication 0.5969015190769554 1.5182214546390218 0.1289585806682958 1.0 0.2593042514165416 10 P33991,Q9NRF9,P09884 3 +Positive regulation of calcium ion transport 0.5293126332477407 1.5153758050228467 0.1296772610312313 1.0 0.2605844676302581 15 P30536,P27695 2 +Regulation of skeletal muscle contraction by calcium ion signaling 0.4765056254136447 1.5134749566130017 0.1301590577703542 1.0 0.2614699656094726 2 P28161 1 +Intracellular sterol transport 0.6598777500499307 1.5116016217491588 0.1306352388821148 1.0 0.2622538901011817 7 O15118 1 +Protein oxidation 0.4761747187293269 1.511452995504091 0.1306730758260608 1.0 0.2622538901011817 2 Q96JJ7 1 +Branched chain amino acid catabolic process 0.5213055637242502 1.5105960940059524 0.1308913897561474 1.0 0.2626091140435837 16 P09622,P11182 2 +Chloride transport 0.5949938690702201 1.5081882132277364 0.1315063630941049 1.0 0.2636764807022494 10 P30536,Q9UHG3 2 +Muscle cell proliferation 0.4734664644580553 1.5070404170521596 0.1318002976869672 1.0 0.2641824951429718 22 P09601,P61586,P09493,P26358 4 +Positive regulation of synaptic transmission glutamatergic 0.4751819986763848 1.5053857009887393 0.1322249431485409 1.0 0.2649501067629654 2 P15104 1 +Membrane protein ectodomain proteolysis 0.6165218201440584 1.5042375697805743 0.1325202073491995 1.0 0.2652953698194563 9 O43847,Q9NZ08,P35579,Q92542,Q9Y5X1 5 +Forebrain generation of neurons 0.6778104791528128 1.5039388438576289 0.1325971141640671 1.0 0.2653612272124719 6 P61586,Q9Y4G8,Q9UPW6 3 +Positive regulation of alpha beta t cell activation 0.6376959081968561 1.5034018168824386 0.1327354583606048 1.0 0.2655544769719875 8 P04439,P61586,P00813 3 +Anoikis 0.6574259714691584 1.5002670125074395 0.1335452507518035 1.0 0.2669225200561206 7 P49815 1 +Phenol containing compound biosynthetic process 0.626780483307565 1.4998045156928344 0.1336650472771285 1.0 0.2670779756345266 5 Q9Y4G8 1 +Negative regulation of macroautophagy 0.5700992161982192 1.4990719735518063 0.1338549614066662 1.0 0.2673733924263891 11 P09601,O15118 2 +Positive regulation of fibroblast proliferation 0.6766664184140562 1.49884804967831 0.1339130560949144 1.0 0.267405398849914 6 Q08211,P14174 2 +Response to dsrna 0.5188182844125904 1.4948846319335587 0.1349445537272271 1.0 0.2692114198023401 16 O60828,Q5KU26,Q9NUD5,P41440 4 +Lymphocyte activation 0.3334807851382538 1.4943726198822822 0.1350782538575106 1.0 0.2693935931968426 89 O96028,P17812,Q9HCL2,P24390,P35579,Q92542,P14174,Q5JVF3,P00813,P61586,P62753,P04439,O96005,Q05655,O14617,P78527,Q96QE3,P46379,Q9UQ84,P09429,Q96L92,Q6IBW4 22 +Cellular response to lipid 0.332811995769052 1.4905960254459334 0.1360675884515261 1.0 0.2709493984122227 93 P30536,Q00839,O95831,P09874,P14174,O43823,P08670,Q8WTV0,P61586,Q86X55,Q14103,P09429,P17844,Q15185,O15118 15 +Positive regulation of alpha beta t cell differentiation 0.6748092369641037 1.490581120601601 0.136071504048429 1.0 0.2709493984122227 6 P00813 1 +Inner mitochondrial membrane organization 0.4943032572100831 1.4898642861102307 0.1362599237254995 1.0 0.2711546885407875 19 Q9BUR5,Q9Y5J9,O60220,Q9Y5L4,Q9Y584 5 +Protein localization to lysosome 0.5377638377064112 1.4861630047452 0.1372360104011494 1.0 0.2728408139223352 13 Q99523,Q14108,P13473,O14617 4 +Pyrimidine deoxyribonucleoside triphosphate metabolic process 0.5744317858021986 1.482009064190893 0.1383378831685111 1.0 0.2747736204434552 4 Q9H773 1 +Activation induced cell death of t cells 0.5741649265728428 1.480642516198931 0.1387018594908649 1.0 0.2750667765753314 4 P49327,Q9HCL2 2 +T cell homeostasis 0.5741649265728428 1.480642516198931 0.1387018594908649 1.0 0.2750667765753314 4 P49327,Q9HCL2 2 +Dna methylation or demethylation 0.4514889517562676 1.4795651577471276 0.1389893306292413 1.0 0.2754649783222507 25 Q9Y2W6,P27695,O75844,P26358 4 +Regulation of catabolic process 0.2731202434767018 1.478652926903324 0.1392330993683326 1.0 0.2758620883993523 287 P30536,P52272,O60506,O00267,Q8WTV0,Q9H2U1,P46777,Q14108,P63244,Q14103,Q969T7,P09601,O15269,O14965,Q9NZJ7,Q9UMY4,Q00535,Q9Y5A7,Q93050,P49815,P21796,O95831,P21333,Q9Y6K9,O43765,P08670,Q5JVF3,P98175,Q9NNW5,Q9C0D3,Q96KQ7,Q96KB5,Q13526,P61289,P07602,Q08J23,O75832,O00178,P19474,P05067,O15118,Q00839,P27695,Q05655,Q8IYI6,Q16850,Q9Y487,P10619,P31751,Q99570,Q9GZP4,O75844,Q9Y5X1,P46379,Q08211,P09429,P53634,Q9Y5K5,Q92945,Q9NV70,P16989 61 +Axis elongation 0.5214823780746934 1.4779843954223957 0.1394119550306483 1.0 0.2760443570638007 3 Q13308 1 +Actin mediated cell contraction 0.5227692662583013 1.4749158923351966 0.1402351571215621 1.0 0.2774150820618265 15 P21333,Q13557,P09493,P60660 4 +Regulation of cell projection organization 0.3229979397180914 1.4746157115093343 0.1403158884422388 1.0 0.2774884215740106 109 Q9UQB8,P27695,O14976,P08670,Q13555,Q9H2U1,Q8NCA5,Q14108,P61586,Q9NR77,Q86X55,Q7L576,O60828,Q00535,P10586,Q9Y4G8 16 +Cellular component assembly involved in morphogenesis 0.5078634692633786 1.472881699546817 0.1407829374653828 1.0 0.2782389149657877 17 Q9NR77 1 +Cellular modified amino acid metabolic process 0.3623391005874045 1.4673078528920096 0.1422923284421653 1.0 0.2811346097539331 56 Q9NVH6,P12532,Q16775,Q6P1A2,P12277,P34897,P34896,Q04760,P04818,Q8NCC3,P00390,P41440,O60725,Q9H2D1,Q9UHG3,Q9UKG9 16 +Response to corticosteroid 0.4407489640952786 1.4660838191897525 0.1426254533035149 1.0 0.2816177015213237 28 O95831,P09874,P61586,P04818,P62826,P16278,Q00839 7 +Regulation of sodium ion transport 0.5341967355192625 1.4649742860249904 0.1429279334481559 1.0 0.2821273121107077 13 Q9UHD1,O95747,Q13557,O43865 4 +Branched chain amino acid metabolic process 0.5065141410750369 1.4641505109365176 0.1431528286922483 1.0 0.2823958346269181 17 P09622,P11182 2 +Astrocyte development 0.6684469971778393 1.4622343470014934 0.1436770024854539 1.0 0.282990712053779 6 P05067 1 +Regulation of protein polymerization 0.3605290220350391 1.460842464343984 0.1440586792266085 1.0 0.2833911993699547 60 Q9UQB8,P07737,Q9UEY8,O15143,O15020,Q05655,P45880,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,Q9BTW9,Q9Y5X1 15 +Multicellular organism reproduction 0.318820481991863 1.4596933598185744 0.1443743676630584 1.0 0.2839243443274751 113 P25440,P11717,Q6IBW4,Q9H2U1,Q14141,O14965,Q96KQ7,Q9BQE5,P00813,P62826,P09622,Q08J23,P05067,O75718,Q99598,Q96PU8,Q9GZP4,Q9Y2W6,P46379,Q8IWV8,Q96MU7,Q15067,A0AVF1,Q9BTX1,P16989,O60879 26 +Second messenger mediated signaling 0.4488521379046037 1.4591449492123738 0.1445252168860911 1.0 0.2841330895539731 25 P49773,P00813,Q9Y4G8 3 +Positive regulation of amyloid beta clearance 0.5174433199283128 1.4554330232509691 0.145549419699271 1.0 0.2857816910980605 3 Q07954 1 +Protein catabolic process in the vacuole 0.6476762400286041 1.4551289769803657 0.1456335584434578 1.0 0.2857816910980605 7 Q8N511,Q96NT0,O14773,P13473,P04062 5 +Lysosomal protein catabolic process 0.6476762400286041 1.4551289769803657 0.1456335584434578 1.0 0.2857816910980605 7 Q8N511,Q96NT0,O14773,P13473,P04062 5 +Skeletal system morphogenesis 0.5050581368509988 1.4547253883841706 0.1457453010571221 1.0 0.2859126955305766 17 Q92896,O75569,O75844,Q9UPW6 4 +Regulation of cell differentiation 0.2860067606713047 1.454006172874864 0.1459445947951803 1.0 0.2862153176544788 198 P30536,Q9UQB8,Q8N4Q0,P26358,Q9H2U1,Q9Y6C9,Q86X55,P55209,O14965,Q00535,Q8WUJ1,Q5JVF3,P00813,P61586,Q7L576,Q08J23,P17844,P05067,Q00839,Q92896,P32929,P27695,P09874,O96005,Q99523,P78527,Q06481,Q9H6W3,Q9Y4G8,Q9GZP4,Q92766,P09429 32 +Regulation of smoothened signaling pathway 0.6059143864181955 1.4508437477504843 0.146823374664911 1.0 0.2875837810077579 9 P63244,Q9BZH6,Q9Y5K5 3 +Cellular lipid catabolic process 0.3591243970702494 1.4498621718039069 0.1470969579869647 1.0 0.2879421820034333 61 P50542,Q8WTV0,Q8NHP8,Q9BWD1,Q8NCC3,P50897,P40939,O15254,Q9UKG9 9 +Regulation of fat cell differentiation 0.5610692392945433 1.4491187336390097 0.1473044272048858 1.0 0.288170803113036 11 Q00839,Q99523,Q86X55,Q8N4Q0 4 +Glycoside metabolic process 0.6263811126077641 1.4488423136177473 0.14738162399652 1.0 0.2882331083451941 8 P06280,Q9NUJ1,P08236 3 +Production of molecular mediator of immune response 0.4152287235406492 1.4473727745749665 0.1477925466766891 1.0 0.2889478396422751 35 O96028,P04439,P14174,Q9H2U1,Q9UQ84,P78527,P09601 7 +Nervous system process 0.328733071621573 1.4467805939448013 0.1479583835982325 1.0 0.2891831138223757 96 Q9UQB8,O75569,O43924,P50542,Q14108,Q99797,P50897,Q92542,Q7L576,Q9Y5J9,P53634,Q9Y5L4,P05067,O75844 14 +Cellular process involved in reproduction in multicellular organism 0.3918898729106616 1.4465483435309536 0.1480234628488084 1.0 0.2892213740753231 46 Q9Y2W6,Q6IBW4,Q96KQ7,P43034,P62826,Q8IWV8,Q96PU8,Q96MU7,P09622,Q08J23,A0AVF1,O14965,Q9GZP4,O60879 14 +Regulation of lipoprotein particle clearance 0.664857972270428 1.4462265037288835 0.1481136822301825 1.0 0.2892767602047196 6 Q9Y2B0 1 +Glucose import 0.5830517878656633 1.4452657655783994 0.1483832499510389 1.0 0.2896572287127774 10 Q06481,Q99523,P31751,Q9BZE9 4 +Organic acid catabolic process 0.3248648351109818 1.444159863394472 0.1486940121174726 1.0 0.2901747439418656 80 Q16836,Q9BWD1,Q8NCC3,P25325,Q92947,P34896,P42126,O15382,P09622,O43808,P00367,P34897,P11182,P40939,P31751,Q9UKG9,Q8IVS2,Q709F0,P50542,P23378,Q15067,O15254 22 +Positive regulation of actin filament depolymerization 0.5148357119665274 1.440860753856588 0.149624025537622 1.0 0.2918104652706736 3 O75083 1 +Histone h2a phosphorylation 0.6141105704600732 1.4393838770511622 0.1500417898692629 1.0 0.2924457578684561 5 O75844 1 +Synaptic vesicle recycling via endosome 0.5659572933558137 1.4385672718317215 0.1502731647130453 1.0 0.2926359600610017 4 Q4V328 1 +Reactive nitrogen species metabolic process 0.5021485862936441 1.4358801605496756 0.151036444750487 1.0 0.2939337546950691 17 P30536,O43169,P35270 3 +Wound healing 0.3780706258656693 1.4328365837101205 0.151904543765148 1.0 0.2954422521943944 50 Q8WTV0,P61586,P42785,P09601,P09493 5 +Protoporphyrinogen ix metabolic process 0.612677867843148 1.432540717073582 0.1519891340198453 1.0 0.2955163462313054 5 P36551,P22830 2 +Regulation of synaptic plasticity 0.4450888305267515 1.4299721672450003 0.1527250074864419 1.0 0.2966970319663609 25 Q9UQB8,P05067,Q9Y4G8 3 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.6121294573978653 1.4299207529176274 0.1527397649961268 1.0 0.2966970319663609 5 P14174 1 +Regulation of cholesterol biosynthetic process 0.6120978611930517 1.4297697969523016 0.1527831003187381 1.0 0.2966970319663609 5 Q6P1A2 1 +Regulation of alcohol biosynthetic process 0.6120978611930517 1.4297697969523016 0.1527831003187381 1.0 0.2966970319663609 5 Q6P1A2 1 +Negative regulation of nf kappab transcription factor activity 0.528242986806544 1.4295652210833096 0.15284184337532 1.0 0.2967204509754227 13 O75832,Q93009,O15111,P19474,Q9UHD1 5 +Mitotic dna replication 0.579673628211406 1.4274340974865924 0.153454808373938 1.0 0.2978194693205342 10 Q14566,O75844 2 +Meiotic spindle organization 0.6602707462750568 1.42574983421322 0.1539405660894715 1.0 0.2985519816164527 6 O14965,P35579 2 +Negative regulation of protein polyubiquitination 0.5634065133099059 1.425474347411993 0.1540201302266124 1.0 0.2985519816164527 4 Q96FW1,Q9Y263 2 +Negative regulation of protein k63 linked ubiquitination 0.5634065133099059 1.425474347411993 0.1540201302266124 1.0 0.2985519816164527 4 Q96FW1,Q9Y263 2 +Fatty acyl coa metabolic process 0.5274878782536424 1.4250707058468788 0.1541367635512167 1.0 0.2985959369495683 13 Q8WVX9,Q13085,P50897,Q9UMR5,Q92947,Q53GQ0,Q9NZ01 7 +Metanephric nephron development 0.5629952433058708 1.42336264388 0.1546310557599437 1.0 0.2991887337626187 4 O95747 1 +Cell differentiation involved in metanephros development 0.5629952433058708 1.42336264388 0.1546310557599437 1.0 0.2991887337626187 4 O95747 1 +Monocarboxylic acid catabolic process 0.3922356450166703 1.422240344670543 0.1549564903146705 1.0 0.2997271614242379 45 P50542,Q9BWD1,Q8NCC3,P40939,O15254,Q9UKG9 6 +Organic hydroxy compound catabolic process 0.5266387791894268 1.420015830678481 0.1556030723470121 1.0 0.3006118929597595 13 Q8WTV0,P30837 2 +Regulation of t cell differentiation 0.5545092753219314 1.4127615634823552 0.1577258432339578 1.0 0.3040103778216144 11 P61586,P00813,O96005,P09429 4 +Zymogen activation 0.6385193883923024 1.412650676570404 0.1577584607755011 1.0 0.3040103778216144 7 Q99538,Q15392 2 +Regulation of response to osmotic stress 0.6084576674190889 1.4123718365799007 0.1578405045329338 1.0 0.3040103778216144 5 P08183 1 +Organonitrogen compound catabolic process 0.2652439779626569 1.4115766101910106 0.1580746634247549 1.0 0.3043691489632664 336 Q8WTV0,Q9NUJ1,P46777,P63244,Q8NCC3,P49773,Q9UHG3,P55786,Q13126,Q9UMY4,Q9Y5A7,Q86UV5,P21333,O43765,P06280,P00813,O43847,P34896,P09622,P49721,P30519,P28074,Q8N511,P00367,P34897,Q16850,P11182,P42892,Q8N3C0,Q9NZ08,P10619,Q99497,Q96DE0,Q9UBV2,O75844,Q7Z6E9,P46379,Q9UIQ6,O00462,P55072,P16278,Q93009,Q86Y37,Q96HY6,P15586,P25325,P09601,Q9H773,Q8NEZ5,Q92890,Q96JB5,Q9Y4X5,Q5T4S7,Q13867,O15382,P25788,O60502,O94966,P63208,Q8WUX9,Q92990,Q9Y263,P50897,Q96RQ3,Q68CQ4,Q8IWV8,P53634,P60900,O14965,Q13526,P61289,O75832,P20618,Q15366,P13473,Q9GZP4,P23378,Q9H7D7,Q15369,O75503,Q96NT0,Q9H1I8,Q99538,Q9C0D3,Q96KB5,Q05655,P08236,A0AVT1,Q9Y5X1,P30260,Q9Y5K5 91 +Dna methylation 0.465524388264577 1.4104585204427325 0.1584043361235316 1.0 0.3049115567538362 21 Q9Y2W6,P09874,Q96KQ7,P26358,O75844 5 +Regulation of autophagy of mitochondrion 0.5123372879157806 1.4102628418668768 0.1584620861274612 1.0 0.3049303722149997 15 P30536,P21796 2 +Mrna pseudouridine synthesis 0.4596293845135789 1.4100801095483435 0.1585160297349437 1.0 0.3049418538121374 2 Q9Y606 1 +Regulation of alpha beta t cell differentiation 0.6376903513340666 1.40880117276374 0.1588939682896935 1.0 0.3054839874317277 7 P09429,P00813,P61586 3 +Cellular response to acid chemical 0.5046893733162878 1.4054298076632448 0.1598935082422814 1.0 0.307126968385597 16 Q9UQB8,Q8IWV8,P26358 3 +T cell migration 0.5967264337450016 1.4044930124348265 0.1601720909859247 1.0 0.3075691269808271 9 P61586 1 +Regulation of lymphocyte apoptotic process 0.6365512241928597 1.403510901739663 0.1604645433995091 1.0 0.3080274753940485 7 P00813,P14174 2 +Dna modification 0.4262544657651178 1.403295114119868 0.1605288545693219 1.0 0.3080274753940485 30 Q03164,P27695,P09874,Q9Y2W6,Q96KQ7,P26358,Q8N3C0,Q93009,O75844 9 +Pyridine containing compound metabolic process 0.5964626466634192 1.403161050944644 0.1605688192175094 1.0 0.3080274753940485 9 Q13126 1 +Nerve development 0.6363469536192591 1.4025621297483384 0.1607474513153941 1.0 0.3082083862928039 7 P42892 1 +Regulation of hormone metabolic process 0.6062941527345356 1.4020257918705163 0.1609075449426151 1.0 0.308422302670465 5 O75844 1 +Response to axon injury 0.5108668136163986 1.4011367145168234 0.1611731944817998 1.0 0.3088383551782693 15 P30536 1 +Neutral lipid metabolic process 0.5288992354614335 1.3992859295542126 0.161727257284985 1.0 0.3097770664486006 12 Q8WTV0,Q8NCC3,Q9HCL2 3 +Negative regulation of transport 0.3487135043940345 1.3964492936524822 0.162579239902648 1.0 0.3105962274785785 69 Q13557,P49257,P00813,Q16850,O95429,Q06481,P09601,Q7L576,P40939,P31751,P09429,Q9UHD1,P05067,Q00535,P21796 15 +Mitochondrial electron transport ubiquinol to cytochrome c 0.6049617521481576 1.3956521606968688 0.1628192668844088 1.0 0.3109613162011126 5 P08574,O14949,Q9UDW1 3 +Mammary gland development 0.472070495177179 1.395240780099252 0.1629432433857611 1.0 0.3110653044202376 20 P00403,Q92766,P52789,P31751,Q13505 5 +Regulation of long chain fatty acid import into cell 0.5065422930029536 1.3944520359759962 0.1631811438536328 1.0 0.311222776540062 3 P31751 1 +Response to hydrogen peroxide 0.4523328505031609 1.3934798569347162 0.1634747320641159 1.0 0.3114644475418227 23 P09601,O95831,Q99720 3 +Cellular response to organic cyclic compound 0.3198411498121439 1.3918718064982254 0.1639612207171508 1.0 0.3122977281624844 106 P27695,O95831,P09874,P26358,P61586,Q5KU26,Q86X55,Q14103,Q92542,Q15185,P17844,P41440,O15118,O60828,Q9NUD5,P05067,Q9Y4G8 17 +Sphingolipid mediated signaling pathway 0.4563203176704289 1.3897490989945285 0.1646050796426112 1.0 0.3134301636334443 2 P63000 1 +Post golgi vesicle mediated transport 0.3980360823141551 1.3852492414216873 0.1659762685786807 1.0 0.3153797199061569 41 O14976,Q9Y2D4,Q9Y4I1,Q8IYI6,Q99523,O15027,P63244,Q8TAG9,O14617,Q96KP1,O43795,Q709C8,P98194,Q9H4A6,Q9NV70,O15127 16 +Lymphocyte migration 0.5493953425819185 1.384384701871925 0.1662406906829865 1.0 0.31578775552333 11 P61586 1 +Leukocyte tethering or rolling 0.5547623985046135 1.3810530926730682 0.1672626367565852 1.0 0.3175392231854408 4 Q9H4A6 1 +Regulation of osteoclast differentiation 0.4546657842488539 1.3795777309986446 0.1677166978940976 1.0 0.3177226815410403 2 P35222 1 +Regulation of cytoplasmic translational initiation 0.4546657842488515 1.37957773099863 0.167716697894102 1.0 0.3177226815410403 2 P40429 1 +Positive regulation of lipid biosynthetic process 0.5916250054963708 1.3787231170092558 0.1679801392069055 1.0 0.3180463999997295 9 Q8WTV0,Q9UHD1 2 +Regulation of leukocyte differentiation 0.4444697533484322 1.3780385831720556 0.168191376023564 1.0 0.3182567389121086 24 O96005,Q5JVF3,P00813,P61586,P78527,P09429 6 +Regulation of ion transmembrane transport 0.3760952510285014 1.377457775838262 0.1683707607353486 1.0 0.3185013557243678 49 P27695,Q13557,O43865,P08183,Q9UHD1,P05067,Q00535,O75844,P21796 9 +Homocysteine metabolic process 0.553783423904617 1.3760176630706265 0.1688161648758885 1.0 0.3191539393073015 4 P25325,P32929 2 +Positive regulation of pattern recognition receptor signaling pathway 0.5698832104804522 1.3756876075458913 0.1689183702551919 1.0 0.3192400352637194 10 Q9NUD5,P41440 2 +Insulin receptor signaling pathway 0.4493836149218919 1.3715046521990213 0.1702176942787419 1.0 0.321006122582838 23 Q9UQB8,P43490,Q15043 3 +Endothelial cell migration 0.4162450533116356 1.371399622039967 0.1702504152339123 1.0 0.321006122582838 31 Q8WTV0,P61586,P42785,P09601,P09429,Q99538 6 +Smooth muscle cell apoptotic process 0.5997056135826938 1.3704950546915171 0.1705324180723959 1.0 0.3214424819893679 5 P26358 1 +G protein coupled receptor signaling pathway 0.3919624877498859 1.3698984633600182 0.1707185994642073 1.0 0.3216980190318712 43 O43865,P11717,Q99523,P00813,P42892,Q99720,Q06481,P07602,Q9Y4G8,Q15043 10 +Regulation of lipid catabolic process 0.6291621245993023 1.369170973979562 0.1709458368890888 1.0 0.3220307466707316 7 Q8WTV0,Q05655,P11802,P31751 4 +Erythrocyte maturation 0.4526803441429596 1.3673672997735928 0.1715102066488318 1.0 0.3229981847288816 2 P11413 1 +Mitochondrion localization 0.4913274990570486 1.3656802667963808 0.1720393406738931 1.0 0.323802798141328 17 P27695,O75153,Q6PJG6,Q66K74 4 +Membrane protein proteolysis 0.5459859061376201 1.3654515766915922 0.1721111627100195 1.0 0.3238420811678166 11 O43847,Q9NZ08,P35579,Q92542,Q9Y5X1 5 +Regulation of heart contraction 0.4538534979025685 1.3640315317381662 0.1725576418911232 1.0 0.3244900508461477 22 P00813,P09493 2 +Negative regulation of mitochondrion organization 0.5047621987088876 1.3632217569513871 0.1728126323239802 1.0 0.3247773776023709 15 P49815,P30536 2 +Negative regulation of atp metabolic process 0.5454791418978144 1.362636546391667 0.1729970849086832 1.0 0.324870488627772 11 P30536,P61586 2 +Regulation of macrophage activation 0.5978920353825896 1.3618100332716194 0.1732578443541346 1.0 0.325133409718004 5 P14174 1 +Long term synaptic potentiation 0.5882335394373693 1.361579378416155 0.1733306668469183 1.0 0.3251740609442187 9 Q92542,P05067 2 +Negative regulation of type i interferon production 0.597778266113458 1.3612651283188184 0.173429918892733 1.0 0.3252320102293675 5 Q92890,Q86UT6,O75531 3 +Regulation of leukocyte proliferation 0.4531718834581258 1.3590492860147794 0.174130971471818 1.0 0.3262902283829231 22 P04439,P14174,Q9HCL2,P00813,Q96QE3 5 +Muscle contraction 0.3952291304868043 1.35860890245356 0.1742705526672081 1.0 0.3264555357361552 41 P00813,P61586,P06753,P09493,P67936 5 +Phosphatidylcholine biosynthetic process 0.6264757688050449 1.3566771489643747 0.1748838162911596 1.0 0.3273149400313931 7 Q6P1A2 1 +Regulation of membrane repolarization 0.5962420099980316 1.3539062790079024 0.1757662800430679 1.0 0.3288697309254459 5 P21333,O75083,O75844 3 +Cell migration involved in sprouting angiogenesis 0.6258196421348119 1.353624925584226 0.1758560705819118 1.0 0.328940901888944 7 P61586 1 +Locomotion 0.2650605094713826 1.353010843898459 0.1760521661180685 1.0 0.3292108172540287 227 P30536,P63167,Q8WTV0,Q8WUW1,P42785,P09601,Q99538,P35579,Q00535,P49815,P07737,P14174,Q9UPW6,P00813,P61586,Q13526,Q7L576,Q5SNT2,P05067,P09493,P27695,Q9Y6A4,P42892,Q06481,P31751,Q96N66,O95429,Q9UH99,Q9Y4G8,P50542,Q92766,P09429,Q6PJG6,O95747,P10586 35 +Amyloid precursor protein catabolic process 0.5092657631227088 1.351941527085253 0.1763940215731976 1.0 0.3295678094846799 14 P27695,Q13526,Q15392,Q92542 4 +Protein targeting to lysosome 0.543393727676829 1.351050004048857 0.1766794152500943 1.0 0.329995405033676 11 Q14108 1 +Lipid oxidation 0.3963456431095811 1.3501888640787325 0.1769554092988838 1.0 0.3304138018518525 40 Q8IVS2,O43808,Q709F0,P50542,Q16836,Q9BWD1,Q15067,Q06481,P40939,Q92947,P31751,O15254,Q9UKG9 13 +T cell differentiation 0.4463613737196473 1.3489720458024363 0.1773459451434966 1.0 0.3308740829569764 23 O96005,P00813,P61586,P24390,O14617,P78527,P09429,Q6IBW4 8 +Lipid storage 0.4887078063167673 1.3486634155802668 0.1774451014921365 1.0 0.3309392796608039 17 Q8WTV0 1 +Skeletal system development 0.379156309628774 1.3466251103313402 0.1781010027395524 1.0 0.3320055321007816 47 O96028,O75569,Q9UPW6,P61586,Q15125,P04818,Q7RTS9,O75844,Q15043,Q92896 10 +Lytic vacuole organization 0.4460382416781996 1.3465621807207782 0.1781212813819486 1.0 0.3320055321007816 23 Q8N511,Q9HC07,Q14108,P50897,O75503,Q96ED9 6 +Amp biosynthetic process 0.5195339576440521 1.3445128139048612 0.178782615618537 1.0 0.3327809644465898 12 P00813 1 +Spermatid differentiation 0.4950867537936689 1.344471183685619 0.1787960686653285 1.0 0.3327809644465898 16 Q96KQ7,P62826,Q96PU8,P09622,Q08J23,A0AVF1,Q9GZP4 7 +Negative regulation of cell differentiation 0.3412008788843893 1.3438625869688794 0.1789928262024491 1.0 0.3330440290816062 73 P30536,Q8N4Q0,P26358,Q99523,P61586,Q9H6W3,Q06481,P09429,Q9Y4G8,P05067,Q00535,Q00839 12 +Nitrogen compound transport 0.2679493053283046 1.343669030527228 0.1790554361725549 1.0 0.3330630237965347 532 P30536,A6NIH7,Q99595,Q8TB61,Q14108,P24390,Q99797,Q9Y282,O43681,O60220,Q5SRE5,P43307,Q9UHD1,Q9NS69,Q9Y584,P55786,Q9NZJ7,Q00535,P55735,P49815,O95831,O60830,O00170,Q13555,Q5JVF3,Q9Y4I1,Q9UI26,Q5JRX3,O43772,P07602,P35580,Q08J23,Q9HD20,P41440,O60725,Q96ED9,Q09161,P27695,O43865,Q9BZH6,Q13769,Q99523,Q16850,Q8IYI6,Q96T51,Q9BZE9,P50897,Q06481,O15260,P10619,Q9Y5J9,P40939,Q96KP1,Q96PU8,Q4V328,P51991,P31751,P13473,Q9BZL1,O95429,O43823,L0R6Q1,P49257,P50542,P46379,Q92945,Q8NFH4,Q96MU7,P08183,Q9BTX1,Q9Y619,Q9Y5L4,Q9H2D1,P84103,Q10713 75 +Antigen processing and presentation of peptide antigen via mhc class i 0.5845934039173466 1.3431694579424895 0.179217108873201 1.0 0.3332168924811132 9 Q9UIQ6,Q9NZ08,P10321 3 +Regulation of the force of heart contraction 0.5936782086694602 1.3416219807712406 0.1797185954526059 1.0 0.3336851217256706 5 Q13557,P05023 2 +Negative regulation of inflammatory response 0.5185938659065513 1.3390102052208828 0.1805673506612299 1.0 0.3346447238380962 12 Q96KB5,P00813,Q6P1A2 3 +Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway 0.4480476505625536 1.3388579227378212 0.1806169299743012 1.0 0.3346447238380962 2 O75351 1 +Macrophage differentiation 0.6226432502299363 1.3388452175621366 0.1806210669140715 1.0 0.3346447238380962 7 P05067 1 +Positive regulation of type i interferon production 0.4639677346317836 1.3386472957228797 0.1806855214483502 1.0 0.3346447238380962 20 Q9BYW2,Q9H6R0,Q9H2U1,Q7Z434,Q08211,O15111,P41440,Q06124,O60828,Q9NUD5 10 +Positive regulation of leukocyte migration 0.5008039593645524 1.3386166135620752 0.1806955148225844 1.0 0.3346447238380962 15 P09429,P61586,P05067,O95747 4 +Ventricular system development 0.622228543020353 1.336915182605599 0.1812503243486953 1.0 0.335476721479414 7 Q9Y4G8,Q96N66 2 +Regulation of phagocytosis 0.5123569535317891 1.3348684660007597 0.1819194001995248 1.0 0.3365191233027298 13 Q8WTV0,P09429,P63244,Q06481 4 +Neurotransmitter uptake 0.6390925141221623 1.3310127944569763 0.1831848010618435 1.0 0.3384658707991504 6 P41440 1 +Protein import 0.3205093825643125 1.3301246897595065 0.1834771919960223 1.0 0.3388727271866338 86 P55735,P49815,O95831,Q99595,O60830,P50542,Q9UI26,P62826,Q06481,Q5SRE5,P13473,Q15388,Q9UHD1,Q92973,Q9NS69 15 +Regulation of mitochondrial membrane potential 0.4621361499269631 1.3258440062505397 0.1848913732029364 1.0 0.3412222903826551 20 P30536,P09874,P63244,Q9BSK2,P55072,P31751,Q99497 7 +Positive regulation of hemopoiesis 0.4920894276525986 1.325424404152005 0.185030427225296 1.0 0.3412807299605286 16 Q5JVF3,P00813,P61586,P78527,P09429 5 +Muscle organ development 0.3986670881460964 1.3239384614518015 0.1855234833113412 1.0 0.3415867586859055 37 P60660,P61586,O95425,P41440,Q00535,P09493,P16989 7 +Positive regulation of arp2 3 complex mediated actin nucleation 0.5436467109470107 1.323833696644917 0.1855582823365753 1.0 0.3415867586859055 4 Q7L576 1 +Positive regulation of actin nucleation 0.5436467109470107 1.323833696644917 0.1855582823365753 1.0 0.3415867586859055 4 Q7L576 1 +Negative regulation of blood circulation 0.493941261116174 1.3237907707909635 0.1855725421243599 1.0 0.3415867586859055 3 P05023 1 +Positive regulation of cell differentiation 0.3077865038704651 1.3227424887300503 0.1859210285803745 1.0 0.3421291423441981 116 P30536,Q9UQB8,Q9H2U1,Q9Y6C9,Q86X55,P55209,O14965,Q8WUJ1,Q5JVF3,P00813,P61586,Q7L576,Q00839,P32929,P27695,P09874,P78527,Q9GZP4,Q9Y4G8,Q92766 20 +Peripheral nervous system development 0.5378037181407715 1.319976042655839 0.1868430168497434 1.0 0.3436327901609252 11 Q9NR77,Q00535 2 +Motor neuron axon guidance 0.5885691812708056 1.3171311244635124 0.1877946757869104 1.0 0.3448325194264848 5 Q00535 1 +Muscle cell apoptotic process 0.514814398531488 1.316881391400628 0.1878783849549901 1.0 0.3448325194264848 12 P09601,P98175,P26358 3 +Positive regulation of macroautophagy 0.4905608095576381 1.315707898517772 0.1882721021386595 1.0 0.3454553929541917 16 P49815,Q9Y6K9,P09601,O15269,P21796 5 +Positive regulation of erad pathway 0.4924289608167126 1.3153012170305078 0.1884086892820597 1.0 0.3455025941734934 3 P46379 1 +Positive regulation of nervous system development 0.3961228292356587 1.3149840570980484 0.1885152606346247 1.0 0.3455025941734934 38 P30536,Q9UQB8,P27695,P55209,Q7L576 5 +Positive regulation of neurogenesis 0.3961228292356587 1.3149840570980484 0.1885152606346247 1.0 0.3455025941734934 38 P30536,Q9UQB8,P27695,P55209,Q7L576 5 +Dna synthesis involved in dna repair 0.5787544282233597 1.3136221550452456 0.1889733892416842 1.0 0.3462423932026939 9 P09884,P28340,P55072 3 +Positive chemotaxis 0.6168676604583953 1.3119582756035355 0.1895342130695838 1.0 0.3470095595907909 7 P49815,P14174 2 +Regulation of cell cycle checkpoint 0.5578340621914595 1.3118940577302716 0.189555882772062 1.0 0.3470095595907909 10 Q13769 1 +Nucleosome mobilization 0.5576720538627791 1.3110357040196163 0.1898457012727319 1.0 0.3473400337620853 10 Q9NRF9,Q9NRL2,Q9NRG0 3 +Regulation of t cell receptor signaling pathway 0.6342121812846998 1.3091457303498648 0.1904849912097042 1.0 0.3483091496343152 6 P00813 1 +Regulation of antigen receptor mediated signaling pathway 0.6342121812846998 1.3091457303498648 0.1904849912097042 1.0 0.3483091496343152 6 P00813 1 +Neuron projection guidance 0.4596739999253165 1.308628083243376 0.1906603632981516 1.0 0.3485295568372308 20 Q7L576,P42892,P05067,Q00535 4 +Small molecule catabolic process 0.3084285730069293 1.305018466192913 0.1918865598967993 1.0 0.3503679904349487 114 Q16775,P50542,Q8WTV0,P00813,Q9BWD1,P11182,Q8NCC3,Q15067,P30837,P09622,P16278,O15382,P40939,O15254,Q13126,Q9UKG9 16 +Positive regulation of cell cell adhesion 0.4285532148352659 1.3014806462840505 0.1930939849068877 1.0 0.352269049388111 25 P04439,Q9HCL2,P00813,P61586,P09429,P41440 6 +Regulation of production of molecular mediator of immune response 0.4284514115184379 1.3006884653431188 0.193365112079185 1.0 0.3526624540531708 25 O96028,P04439,P14174,Q9H2U1,P09601 5 +Forebrain cell migration 0.5338660178010431 1.298075600250979 0.1942613578241419 1.0 0.3539923137414695 11 P50542,P43034,P61586,Q96N66,Q00535 5 +Leukocyte migration 0.3796690953434738 1.2973037346514356 0.1945266999061017 1.0 0.3542726947287056 45 P14174,P00813,P61586,P09601,P09429,Q99538,O95747,P35579,P05067 9 +Positive regulation of developmental process 0.2877033634462047 1.2970402973517938 0.1946173218524756 1.0 0.3542981942364817 181 P30536,Q9UQB8,O96028,Q9HCL2,Q9H2U1,Q9Y6C9,Q86X55,P55209,P09601,O14965,Q8WUJ1,Q5JVF3,P00813,P61586,Q7L576,P41440,Q00839,P32929,P27695,P09874,P78527,Q9NZ08,Q68CQ4,Q9Y4G8,Q9GZP4,Q96QE3,Q969H8,P50542,Q92766,P09429,P52789,P16989 32 +Carbohydrate transmembrane transport 0.5114096629663547 1.2969389714899031 0.1946521860090928 1.0 0.3542981942364817 12 Q06481,Q99523,P31751,Q9BZE9 4 +Positive regulation of cell adhesion 0.351341300116232 1.296291745211792 0.194874991451077 1.0 0.3546021888528615 54 P04439,Q9HCL2,P00813,P61586,Q99797,Q92766,P41440,O95429,P09493 9 +Negative regulation of receptor signaling pathway via stat 0.4404367968233043 1.291976061503216 0.1963654348403085 1.0 0.3564977731633822 2 P30153 1 +Negative regulation of receptor signaling pathway via jak stat 0.4404367968233043 1.291976061503216 0.1963654348403085 1.0 0.3564977731633822 2 P30153 1 +T cell apoptotic process 0.5324192291139429 1.290027093884829 0.1970412511453161 1.0 0.3575204659662087 11 P49327,P00813,P24390,Q9HCL2 4 +Calcium mediated signaling 0.4722830975851847 1.2886359688463296 0.1975246726148332 1.0 0.3582953250969977 18 Q9UHD1,P49773,P00813,O75844 4 +Organ growth 0.4791825259389726 1.2867392968409337 0.1981851712643738 1.0 0.359390855508234 17 Q96KQ7,Q9NZJ7,P49840,P07602,O00763,Q06124,P16989,O75844 8 +T cell differentiation in thymus 0.5526337744325283 1.2843361225450196 0.1990243728685312 1.0 0.3607068474343839 10 P00813,O96005,P78527,Q6IBW4 4 +Negative regulation of secretion 0.4854916332803221 1.2834755961720434 0.1993255039941366 1.0 0.3609438471187272 16 P09601,P00813,Q16850 3 +Actin filament bundle organization 0.3850140269754236 1.2811477969918044 0.2001417580843667 1.0 0.362112443604963 42 Q9UQB8,P61586,P09493 3 +Double strand break repair via break induced replication 0.5916344436189496 1.2805983441090814 0.2003347819366876 1.0 0.3622554406798254 8 P33991,Q9BRT9,Q14566 3 +Response to toxic substance 0.3824270264100361 1.277296352637456 0.2014976408330699 1.0 0.3638907119518002 43 O14880,O95831,Q96KQ7,P04818,Q15165,P07099,P36551,P30044,P08183,P00390,Q6DKJ4 11 +Rna phosphodiester bond hydrolysis endonucleolytic 0.3991392453232534 1.2772177600574823 0.2015253785510284 1.0 0.3638907119518002 32 P27695,Q9UQ84,Q99598,O75691,Q14137,Q96DE0,Q5SY16,Q9ULX3 8 +Reactive oxygen species biosynthetic process 0.5296369311352541 1.274546936646718 0.2024696494063018 1.0 0.3653881577587889 11 P61586,P00403,Q9BSK2,Q15067 4 +Positive regulation of neuron projection development 0.421319322435247 1.273646982659882 0.202788553615604 1.0 0.3658597918764629 26 Q7L576,Q9UQB8,Q14108,Q9Y4G8 4 +Regulation of transcription involved in g1 s transition of mitotic cell cycle 0.5336632123051871 1.2723784630826054 0.2032386824340415 1.0 0.3664638483831965 4 Q00535 1 +Dna catabolic process endonucleolytic 0.6079831383635729 1.2705735360656638 0.203880406596862 1.0 0.3675166943646213 7 O95831 1 +Response to reactive oxygen species 0.3981563527194158 1.2686555635232666 0.2045639376777168 1.0 0.3683016153061916 32 P27695,O95831,Q05655,Q99720,P09601,P30044,O15111,P09493 8 +Negative regulation of gene expression 0.2649570910939262 1.2685388945770255 0.2046055701142484 1.0 0.3683016153061916 267 P30536,Q9UGR2,P52272,Q9Y2B0,Q9Y333,P26358,Q9H2U1,Q14103,Q969T7,P09601,Q99538,O14965,Q9NRF9,Q6PGP7,P14174,P08670,Q5JVF3,P98175,Q5KU26,P04818,P62826,P42694,P17844,P05067,Q09161,Q00839,Q92896,Q9BRJ7,P27695,O75569,Q8ND04,Q99598,Q06481,Q96DE0,Q9UKA9,Q9UK61,O75844,Q9Y2W6,Q9Y6X9,Q8IWR0,O43823,O75531,Q5T280,Q8IWV8,P09429,P49458,Q92945,Q10713,P16989 49 +Fatty acid beta oxidation 0.3950748634396787 1.267324335461235 0.2050393424466681 1.0 0.3686114764430611 35 Q8IVS2,O43808,Q709F0,P50542,Q16836,Q9BWD1,Q15067,P40939,Q92947,P31751,O15254,Q9UKG9 12 +Connective tissue development 0.4299205655719894 1.2672450526565016 0.2050676810419547 1.0 0.3686114764430611 24 Q9UPW6,P04818,O75844,P43490,Q15043,Q92896 6 +Protein localization to organelle 0.2635213020279167 1.2661835765390124 0.2054473660111269 1.0 0.369085205869622 309 P30536,O14976,Q99595,Q14108,Q9Y6C9,P24390,Q99797,Q96DY7,O43681,O60220,Q5SRE5,O14965,Q9UHD1,Q9NS69,Q9Y584,P55786,Q00535,P55735,P49815,O95831,O60830,O00170,Q9UI26,Q13526,Q5JRX3,Q9UFC0,Q8IY18,Q00839,P09874,Q99523,Q06481,Q9Y5J9,P13473,Q68CQ4,Q9UK61,O95429,Q9UH99,P49257,P50542,P46379,P52789,A0AVF1,Q9BZL1,Q9Y5L4,Q10713 45 +Purine nucleoside monophosphate biosynthetic process 0.4947673100426002 1.263606469292778 0.2063713104422611 1.0 0.3704944205481851 14 P00813 1 +Positive regulation of muscle hypertrophy 0.577261036756447 1.2628846675216752 0.2066306308838492 1.0 0.3707917249852472 5 P09874 1 +Positive regulation of cytoplasmic translation 0.5055337317694706 1.2625101289999314 0.2067652838638551 1.0 0.3709286322999333 12 Q00839,Q9H2U1,Q08211,Q14103,P16989 5 +Regulation of actin cytoskeleton reorganization 0.5877820429435499 1.2619067614062482 0.206982338737578 1.0 0.371213246336356 8 Q9UQB8 1 +Regulation of glycoprotein metabolic process 0.5482772361101378 1.261242528191853 0.2072214805373162 1.0 0.3712565008560596 10 Q99805,Q92542 2 +Extracellular matrix disassembly 0.587634500763032 1.26119083928083 0.2072400983381528 1.0 0.3712565008560596 8 Q8IYI6,P41440 2 +Establishment of tissue polarity 0.5676385818355716 1.257332575664506 0.2086332328162985 1.0 0.3732352632393634 9 O95487,P43034,P61586,Q13308,P60953 5 +Positive regulation of isotype switching 0.5676358304713232 1.2573186391358893 0.2086382772639172 1.0 0.3732352632393634 9 O96028,Q96FZ2,Q96QE3 3 +Positive regulation of b cell mediated immunity 0.5676358304713232 1.2573186391358893 0.2086382772639172 1.0 0.3732352632393634 9 O96028,Q96FZ2,Q96QE3 3 +Carbohydrate derivative catabolic process 0.3958177282327875 1.2555218036108406 0.2092893980692944 1.0 0.3742698822089488 33 P15586,Q9NUJ1,P00813,P16278,Q96DE0,Q9H773,P49773,Q13126 8 +Regulation of transport 0.2643009544047691 1.2545636362362285 0.2096372110870898 1.0 0.3746005380009961 290 P30536,Q9BZF3,Q6P1A2,Q8WTV0,Q9Y282,P09601,Q9UHD1,P55786,Q00535,P21796,P49815,P14174,Q13555,P00813,P61586,Q7L576,Q08J23,P35580,P41440,P05067,P27695,O43865,Q96T51,Q16850,Q9BZE9,P50897,Q06481,O15260,P40939,Q4V328,P31751,O95429,O75844,Q13557,P49257,P09429,P52789,O95747,P08183,Q9BZL1 40 +Regulation of isotype switching 0.52590147866119 1.2537603431813829 0.2099291273855033 1.0 0.3749113609615788 11 O96028,Q96FZ2,Q96QE3 3 +Regulation of b cell mediated immunity 0.52590147866119 1.2537603431813829 0.2099291273855033 1.0 0.3749113609615788 11 O96028,Q96FZ2,Q96QE3 3 +Fertilization 0.4138316736381743 1.252935272656495 0.2102292638242631 1.0 0.3751311625117957 29 Q9Y2W6,Q96KQ7,P45880,Q96CW5,P55769,P35579,P16989,Q9GZP4 8 +Phosphatidylinositol metabolic process 0.4516011465402349 1.2521541248748385 0.2105137085370778 1.0 0.3753226175208041 20 Q01968,Q6UWP7,O14735,Q99570,Q10713,Q96N66 6 +Synaptic signaling 0.3227256947692467 1.2467422751843638 0.2124920124468436 1.0 0.3784251137887752 77 Q9UQB8,P27695,Q9NR77,P05067,Q7L576,P41440,Q92542,Q9Y4G8 8 +Positive regulation of phospholipid metabolic process 0.5736043405990339 1.2453361911915086 0.2130081976474631 1.0 0.3791319250202396 5 Q9UHD1 1 +Dendrite development 0.3832826114861873 1.2451654867239188 0.2130709262562264 1.0 0.3791374040550323 41 Q9UQB8,Q9H2U1,Q86X55,P61586,Q7L576,O60828,P05067,Q9Y4G8 8 +Positive regulation of intracellular signal transduction 0.2936560086518395 1.2430948175588197 0.2138328952998396 1.0 0.3799613873429636 132 Q8TB61,Q9UMX5,Q9H2U1,P09601,P49773,P55735,P61927,Q9Y6K9,P14174,Q5JVF3,P00813,P61586,P17844,P19474,P05067,P32929,O75569,O15111,Q9NUD5,O95429,Q9Y4G8,Q969H8 22 +Tissue migration 0.3688357180753614 1.241377447455943 0.2144663463952814 1.0 0.380874014442137 47 P07737,Q8WTV0,P61586,Q92766,P42785,P09601,P09429,Q99538 8 +Inner cell mass cell proliferation 0.5727410661335111 1.2411931264435798 0.2145344134240074 1.0 0.3808884725483216 5 Q9BRT9,Q86XI2 2 +Negative regulation of viral process 0.4651320384862731 1.241018068401223 0.2145990741943269 1.0 0.3808968767325165 18 Q9Y6X9,P19474,O75531 3 +Regulation of receptor catabolic process 0.4789804700430394 1.2397551761387655 0.2150659620133648 1.0 0.3812996525960799 3 P18031,Q96J02 2 +Establishment of lymphocyte polarity 0.526472003008923 1.2352954157307938 0.2167205792467545 1.0 0.3836980506106886 4 P35579 1 +Regulation of cell junction assembly 0.4124378107566909 1.2334061975540556 0.2174242539130912 1.0 0.38441641965295 27 P61586,P05067,Q9Y4G8 3 +Golgi to vacuole transport 0.6173176111884415 1.2333941855264938 0.217428733268149 1.0 0.38441641965295 6 Q99523,O14976 2 +Pyrimidine deoxyribonucleotide metabolic process 0.616565996783425 1.2300232738116326 0.2186883896124229 1.0 0.3861470563148174 6 Q9H773,P34896,P04818,P32321 4 +Positive regulation of leukocyte cell cell adhesion 0.4484295685317772 1.2299619340438168 0.2187113597755416 1.0 0.3861470563148174 20 P04439,Q9HCL2,P00813,P61586,P09429 5 +Cellular response to oxygen levels 0.3919495227167238 1.2297884588440569 0.2187763311511008 1.0 0.3861545017485134 34 Q96A26,O95831,Q8N511,Q9Y487,P09601,P55786 6 +Actin cytoskeleton reorganization 0.430164794217112 1.2280728761731714 0.2194196120392177 1.0 0.3869675510880322 23 Q9UQB8 1 +Regulation of skeletal muscle contraction 0.4766633565044722 1.2267342789411133 0.2199224793888765 1.0 0.3875923932348258 3 P28161,Q99622 2 +Negative regulation of stress activated protein kinase signaling cascade 0.5416604057865605 1.2261620290785935 0.2201377071530377 1.0 0.3877733690748677 10 Q96KB5,P43034,P47897,P31689,P78318,P51452 6 +Sulfur compound biosynthetic process 0.3812687878213096 1.2260454427466094 0.2201815747311513 1.0 0.3877733690748677 41 Q16775,Q8TB61,P50897,P09622,Q9UMR5,Q13126,P32929 7 +Apoptotic cell clearance 0.5802395926385497 1.2253058768543588 0.2204599949717889 1.0 0.3881561573519917 8 Q8WTV0,P09429 2 +Glial cell migration 0.5206211945983014 1.224374679788497 0.2208109165370781 1.0 0.3883437148615575 11 P30536,P43034,Q00535,Q96N66 4 +Regulation of heart rate 0.5203799507988662 1.223032132628677 0.2213175600498516 1.0 0.388713165096233 11 P00813 1 +Regulation of multicellular organismal development 0.2907167017495042 1.2228458452172777 0.2213879259987985 1.0 0.388713165096233 160 P30536,Q9UQB8,Q9H2U1,P55209,P09601,Q00535,Q5JVF3,P00813,P61586,Q7L576,Q92896,P27695,O96005,P78527,Q9NZ08,Q06481,Q68CQ4,Q9Y4G8,O75844,Q9GZP4,Q969H8,P46379,P09429,P53634,P52789 25 +Male gamete generation 0.3363963411408129 1.2216134780127494 0.2218538293263727 1.0 0.389208650068569 67 P25440,P11717,Q9H2U1,Q14141,Q96KQ7,P62826,P09622,Q08J23,O75718,Q99598,Q96PU8,Q9GZP4,Q9Y2W6,P46379,Q8IWV8,Q96MU7,Q15067,A0AVF1,Q9BTX1,P16989 20 +Response to type i interferon 0.4817529939286412 1.2200616163391262 0.2224415178625756 1.0 0.3900243551819394 15 Q9BYW2,Q7Z434,P34897,Q9Y3Z3,Q14166,Q06124 6 +Adult locomotory behavior 0.481687122592118 1.2196515747352383 0.2225969862199539 1.0 0.3901893117523517 15 P05067,O15118,O75844 3 +Forebrain neuron differentiation 0.5680494703286088 1.2186767385860398 0.2229669101725324 1.0 0.3905159943073014 5 Q9Y4G8,Q9UPW6 2 +Positive regulation of dendritic cell cytokine production 0.567728792759923 1.2171377391483824 0.223551814003525 1.0 0.3911079905880555 5 Q9H2U1,Q92499 2 +Myeloid dendritic cell cytokine production 0.567728792759923 1.2171377391483824 0.223551814003525 1.0 0.3911079905880555 5 Q9H2U1,Q92499 2 +Dendritic cell cytokine production 0.567728792759923 1.2171377391483824 0.223551814003525 1.0 0.3911079905880555 5 Q9H2U1,Q92499 2 +Protein polymerization 0.3294414215366131 1.2165759317837723 0.2237656046819658 1.0 0.3913742937145225 75 Q9UQB8,P07737,Q9UEY8,O15143,O15020,Q05655,Q9Y5X1,P45880,P61586,Q13526,O95425,Q96CW5,Q13045,Q7L576,Q96F07,O95429,Q9BTW9,Q08379 18 +Golgi to plasma membrane transport 0.428436795553363 1.215168993169675 0.2243016438277254 1.0 0.3920960528517664 23 Q9Y2D4,O15027,Q8TAG9,Q8IYI6,P63244,Q96KP1,P98194,Q9H4A6,Q9NV70 9 +Regulation of mononuclear cell migration 0.4803263800112943 1.2111812968983653 0.2258259291852891 1.0 0.3939142171049656 15 P09429,P61586,P05067,O95747 4 +Granulocyte differentiation 0.5662869522860954 1.210218170034662 0.2261951876643892 1.0 0.3944297977489323 5 Q14739 1 +Regulation of plasma lipoprotein particle levels 0.4911989954269494 1.208480389748396 0.2268625343940569 1.0 0.3952681657370135 13 Q8WTV0,P09601,Q9Y2B0,Q6P1A2 4 +Cardiac muscle cell membrane repolarization 0.6113937498805783 1.2068270377935086 0.2274987610947136 1.0 0.3961977737900626 6 P21333,O75844,P05023 3 +Proton transporting two sector atpase complex assembly 0.6113810220197989 1.2067699597195043 0.2275207480071945 1.0 0.3961977737900626 6 Q9BUB7,Q8N511 2 +Dendrite extension 0.6103981361595822 1.2023622819021234 0.2292231960177582 1.0 0.3982894023753064 6 Q7L576,Q96F07,Q9Y263 3 +Regulation of cell death 0.259831485204236 1.1956453032581669 0.2318350044559249 1.0 0.4020581959950502 319 P30536,P00403,P11717,Q9UMX5,P26358,Q9HCL2,P63167,Q9Y6C9,P09601,Q9NYF8,O15269,O14965,Q9UHD1,Q9NS69,Q9NZJ7,Q00535,P21796,O95831,Q9Y6K9,P14174,P98175,Q5JVF3,P00813,P61586,Q15392,P61289,O75832,Q7Z7L1,O15118,P32929,P27695,P09874,O75569,P78527,Q99720,P50897,P31751,O95429,Q9Y4G8,Q96QE3,Q96A26,Q86XL3,Q969H8,Q13557,P45880,P46379,P09429,P53634,P30044,O95747,P16989 51 +Regulation of steroid metabolic process 0.4834846451399585 1.194824232110484 0.2321557106272902 1.0 0.4025045544863766 14 P30536 1 +Mononuclear cell differentiation 0.3757778060425816 1.1924877986863651 0.233070032136585 1.0 0.4033196635611583 42 P49327,O96005,Q5JVF3,Q13769,P00813,P61586,P24390,O14617,P78527,P09429,P35579,Q6IBW4 12 +Regulation of carbohydrate catabolic process 0.4828625525456237 1.1910325122936238 0.2336408216673355 1.0 0.4040873639503632 14 Q14108 1 +Response to interleukin 4 0.5897929780832601 1.185812777201919 0.2356962444821428 1.0 0.4068672813494026 7 P39023,P49327,P11802 3 +Dsrna processing 0.4290145828768306 1.1822520368866107 0.2371057105624201 1.0 0.408979512128186 22 Q9UGR2,Q8IWR0,O75569,Q99598,P17844,O75844 6 +Isoprenoid metabolic process 0.418699610666966 1.1817259085537015 0.2373144746502395 1.0 0.4090208843163027 24 P48449,Q9HB40,P61916 3 +Dna catabolic process 0.5712498178818952 1.1816869763438052 0.2373299278411775 1.0 0.4090208843163027 8 O95831 1 +Positive regulation of cell death 0.3035896809889796 1.1787050031581126 0.2385156627161708 1.0 0.41050786683563 110 P30536,P00403,P11717,P63167,Q9Y6C9,P09601,Q9NZJ7,Q9NS69,Q00535,O95831,P98175,P61586,Q7Z7L1,P09874,O75569,P78527,Q9Y4G8,Q96A26,Q13557,P09429,P53634 21 +Vascular transport 0.4911225449068804 1.1780606799196944 0.2387724161227125 1.0 0.4107207650252049 12 P08183,P41440 2 +Protein localization to cell junction 0.4284210695186849 1.1779081635857105 0.238833220190868 1.0 0.4107207650252049 22 Q9UQB8,Q00535 2 +Immune response 0.2742532244179989 1.1757930337221627 0.2396775908300432 1.0 0.4117272344096635 196 O96028,P10321,Q9H2U1,P09601,P36915,Q9Y6K9,P14174,P08670,P00813,Q5KU26,Q14166,P19474,P41440,P05067,P04439,O75569,Q9Y487,P78527,Q9NZ08,Q06481,Q15366,O15111,O60828,Q9NUD5,Q96QE3,O43823,P68371,O75531,P46379,Q9UQ84,P62888,P53634 32 +Positive regulation of i kappab kinase nf kappab signaling 0.3867095119716678 1.1755191331627377 0.2397870870638265 1.0 0.4118040327959151 33 Q9Y6K9,Q8TB61,Q9H2U1,P61586,P09601,P19474,P32929 7 +Mitotic intra s dna damage checkpoint signaling 0.5147080208349138 1.1746346267017034 0.2401409238112157 1.0 0.4121889580729374 4 P43246,Q14676 2 +Positive regulation of response to endoplasmic reticulum stress 0.5588296787811242 1.1744363161892717 0.240220306149838 1.0 0.4122138946782858 5 P46379,P57088 2 +Taxis 0.3354254370998591 1.1738428526656226 0.2404579759992948 1.0 0.4123167844984455 62 P49815,P14174,P61586,P42892,P09429,Q7L576,Q99538,P84095,O95747,P05067,Q00535 11 +Pyrimidine deoxyribonucleotide biosynthetic process 0.5584916281414999 1.1728146532214638 0.2408701406560103 1.0 0.4126758751281522 5 P34896,P04818,P32321 3 +Amyloid precursor protein metabolic process 0.4611819885082372 1.1696461289824205 0.2421434056057481 1.0 0.4143951227867891 17 P27695,Q13526,Q15392,Q92542 4 +Trna methylation 0.5106418216337327 1.168850602648933 0.2424638285221059 1.0 0.4147201544904481 11 Q9BV44,Q9NNW5,Q7Z2T5,Q08J23,Q7Z4G4 5 +Regulation of leukocyte chemotaxis 0.4734492758278433 1.1683835208716504 0.242652099083851 1.0 0.4149305197140051 15 P09429,O95747,P14174 3 +Regulation of peptidyl tyrosine phosphorylation 0.4079136867730046 1.1676059183333878 0.2429657618267202 1.0 0.4153551323751032 26 Q05655,P14174,Q9H2P0,Q86XI2,O95684,P63244,Q99816,Q06124,P05067 9 +Negative regulation of response to biotic stimulus 0.4219071047257441 1.166419757794254 0.2434447740515735 1.0 0.415950264481667 23 P04439,Q14166,P19474,O75531 4 +Scarna localization to cajal body 0.5568359346736067 1.1648727817734204 0.244070492445555 1.0 0.4169072964213781 5 P17987,P50991 2 +Negative regulation of cell junction assembly 0.6019459242001606 1.1644681075160517 0.2442343606491568 1.0 0.4170751199049007 6 P63167 1 +Vascular endothelial growth factor signaling pathway 0.4195896757114584 1.1634560527590143 0.2446445187743817 1.0 0.417551171141238 2 O00159 1 +Positive regulation of cell migration by vascular endothelial growth factor signaling pathway 0.4195896757114584 1.1634560527590143 0.2446445187743817 1.0 0.417551171141238 2 O00159 1 +Negative regulation of protein catabolic process 0.3761338779498059 1.1603658854672585 0.2458998700894388 1.0 0.4193836972183556 40 P21333,O43765,Q96JB5,Q96KB5,P46379,P46777,Q13526,Q16850,P10619,Q99497,Q93009,Q9Y5K5,Q9UMY4,Q96HY6 14 +Actin filament severing 0.5668160794193986 1.1601828572893185 0.2459743649739092 1.0 0.4193836972183556 8 P35579,O95425,Q13045 3 +Protein localization to vacuole 0.4529882107702031 1.1601637795433344 0.2459821307787963 1.0 0.4193836972183556 18 Q99523,Q14108,O14617,P13473,Q99570,Q9Y2T2 6 +Positive regulation of cell size 0.4189278623428297 1.1593778844663412 0.2463021873478743 1.0 0.4198167612719467 2 O60341 1 +Negative regulation of protein modification by small protein conjugation or removal 0.3846449797183982 1.1573972956072327 0.247110078455718 1.0 0.420855214004433 33 P30536,P19474,Q9UHD1,Q00535,Q6DKJ4 5 +Regulation of cell aging 0.5283819322422163 1.1557846372917588 0.2477692584146993 1.0 0.4216389307854963 10 P14174 1 +Rna capping 0.5109315264050452 1.1551704924384545 0.2480206156734872 1.0 0.4219537026821962 4 Q09161 1 +Sulfur amino acid metabolic process 0.5081015209656209 1.154723735377329 0.2482035765227732 1.0 0.4220591732838814 11 P52788,Q13126,P25325,P32929 4 +Dopamine receptor signaling pathway 0.565118100377445 1.1519498523277183 0.24934168088103 1.0 0.4234078877050031 8 Q92542,P21333,P62873 3 +Response to abiotic stimulus 0.2713622750274486 1.1515854605448403 0.2494914588360279 1.0 0.4234359712581559 199 P30536,P00403,Q9H2U1,Q96NT0,Q14103,P09601,P22830,Q9UHD1,P55786,Q00535,O95831,P00813,P61586,Q13526,Q7L576,P30519,P05067,Q8N511,P09874,Q9Y487,P78527,Q06481,P31751,P09884,O75844,P00846,Q96A26,P52789,Q6PJG6,O95747,P08183,P16989 32 +Negative regulation of nucleocytoplasmic transport 0.5987566260140451 1.1501757132909431 0.2500715071072403 1.0 0.4243071273821729 6 Q9UHD1,Q00535 2 +Negative regulation of endoplasmic reticulum unfolded protein response 0.5536413726811074 1.1495529516337648 0.2503280455515855 1.0 0.4244313108050314 5 P63244,Q96HY6 2 +Immune response regulating cell surface receptor signaling pathway 0.4088311088274037 1.147977408001221 0.2509778903849309 1.0 0.4253907923430989 25 P04439,Q9Y6K9,P46379,P00813,Q06481 5 +Cellular response to hydrogen peroxide 0.4509360707440848 1.1465093902400003 0.2515844440910482 1.0 0.4261181807610347 18 P27695,Q05655,O95831,P63244,Q99720 5 +Neurotransmitter receptor transport 0.5974645716920481 1.1443868819005718 0.2524632260727077 1.0 0.4272247776672339 6 Q4V328 1 +Positive regulation of ossification 0.5086603759303396 1.1434687986234613 0.2528440020852431 1.0 0.4276414255598205 4 O95747 1 +Collagen catabolic process 0.4614366103939118 1.1412004731971124 0.2537865074799446 1.0 0.428779117900725 3 P05556,Q9UBG0 2 +Negative regulation of cellular response to insulin stimulus 0.579573270279345 1.1382227071211013 0.2550274992616779 1.0 0.4303038984091384 7 P49815,Q06481 2 +Embryonic forelimb morphogenesis 0.5068552671871204 1.1341707929763354 0.2567229128513526 1.0 0.432475704766286 4 O94788,O95747 2 +Regulation of cell development 0.3034989683409895 1.1311452948736338 0.257993942568691 1.0 0.434386622242808 81 P30536,Q9UQB8,P27695,Q9H2U1,P55209,P78527,Q06481,Q7L576,O14965,Q9Y4G8 10 +Pinocytosis 0.5943730683220354 1.1305395229727273 0.2582489543865875 1.0 0.4347008352969148 6 P50897 1 +Skeletal muscle organ development 0.3994625064062137 1.129086071081168 0.2588615265875764 1.0 0.4353779253640898 27 P60660,P61586,O95425,P41440,Q00535,P16989 6 +Cellular response to osmotic stress 0.4777984863629437 1.128463388341537 0.2591242704365943 1.0 0.4353779253640898 13 P30536 1 +Somatic diversification of immunoglobulins involved in immune response 0.467027397585589 1.128448170249324 0.2591306940925664 1.0 0.4353779253640898 15 O96028,Q9UQ84,Q12888,Q96FZ2,Q96QE3 5 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.467027397585589 1.128448170249324 0.2591306940925664 1.0 0.4353779253640898 15 O96028,Q9UQ84,Q12888,Q96FZ2,Q96QE3 5 +Gamma aminobutyric acid metabolic process 0.4136333553937875 1.126766564998882 0.2598411903030924 1.0 0.4363409790135945 2 O43175 1 +Metencephalon development 0.3987394270585196 1.1258618923009212 0.2602239816307339 1.0 0.4368683643013588 28 P27695,O15020,O14949,O95487,P12277,Q5KU26,Q14103,Q9UKA9,Q06124,Q92542,Q00535 11 +Regulation of synapse structure or activity 0.3925370176145626 1.1220758607303176 0.2618301865098669 1.0 0.4392393775647906 30 Q9UQB8,Q9H2U1,P61586,P50897,Q7L576,P05067,Q00535 7 +Mitochondrial membrane organization 0.3619304943448792 1.1210817548405672 0.2622530641527363 1.0 0.4396873475568899 45 Q9Y584,P50542,Q9BUR5,P45880,O60220,Q9Y5J9,Q9Y5L4,Q9NS69 8 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.4656593189956644 1.119946058829918 0.2627367491779866 1.0 0.4401567679955938 15 P46379,P17844,P14174,P49773 4 +Negative regulation of protein secretion 0.5754037862097092 1.118822725346699 0.2632157746723527 1.0 0.4408430734696901 7 Q16836,Q16850,P17858,P40939,Q06124 5 +Response to lipid 0.2867277348271823 1.1179439332614989 0.263590939831682 1.0 0.4413551142176424 134 P30536,P11717,Q8WTV0,Q86X55,Q14103,Q13126,O95831,P14174,P08670,P61586,P04818,P17844,Q15185,Q00839,O15118,P09874,O43823,P23378,P09429,P16278 20 +Phosphatidylinositol biosynthetic process 0.4531744207527836 1.1176091466012816 0.2637339606132993 1.0 0.4414782864519701 17 Q01968,O00443,Q96N66,O14735,Q99570,Q9Y217,Q10713 7 +Actin filament based transport 0.55796017485139 1.1172625862260377 0.2638820675024986 1.0 0.4416055722368419 8 Q9Y4I1,Q8WXH0,Q9UH99 3 +Endocytosis 0.2975820805324514 1.1171061138309104 0.2639489567224296 1.0 0.4416055722368419 113 P49815,O14976,P11717,Q5VW38,Q8WTV0,Q99523,Q14108,Q5KU26,P50897,Q06481,O15260,P41440,Q96ED9,P05067,O15118 15 +Nuclear transcribed mrna catabolic process deadenylation independent decay 0.4119788219722096 1.1165817777623062 0.264173186491655 1.0 0.4417481645201155 2 Q96F86 1 +Neuron death in response to oxidative stress 0.5748047584604079 1.1160365334335491 0.2644064968526889 1.0 0.4419057833278177 7 P09874,Q15233,P63244,Q99497,P35222 5 +Organophosphate biosynthetic process 0.2859454785616552 1.1121217934132088 0.2660857876021962 1.0 0.4442451447332701 153 Q9Y217,P00403,Q6P1A2,P17812,P12277,Q8TB61,Q9HCL2,P35790,O15269,Q9NPH0,Q9UHD1,Q13057,P00813,P04818,P09622,Q99943,P55263,Q86YN1,P12532,P09874,P32321,P50897,Q96N66,Q99570,P43490,Q9NZ01,P04183,P00846,Q01968,P56134,Q9UMR5,Q6UWP7,O14735,Q10713 34 +Forebrain neuron development 0.502022580634146 1.1092909430059037 0.2673046909642975 1.0 0.4459287705430644 4 Q9Y4G8 1 +Nucleotide excision repair dna incision 0.4553440763999424 1.1070198213221436 0.2682853586416414 1.0 0.4473299421632404 3 P19447 1 +Fibroblast proliferation 0.474102795452641 1.1064232217705925 0.268543379004591 1.0 0.4476427267120851 13 P14174 1 +Regulation of trans synaptic signaling 0.3378244756178178 1.1060304415502769 0.2687133435683511 1.0 0.4476912219450694 53 Q9UQB8,P05067,Q7L576,P41440,Q92542,Q9Y4G8 6 +Regulation of toll like receptor signaling pathway 0.5552456490226829 1.1041181164503888 0.2695419035320634 1.0 0.4488229433114989 8 Q06481,P41440 2 +Cellular response to leucine starvation 0.4548162859980164 1.104060684729525 0.2695668142642997 1.0 0.4488229433114989 3 Q92616,Q9P2J5 2 +Fatty acid transport 0.4510491438819286 1.103811115890328 0.2696750818921671 1.0 0.4488229433114989 17 Q9UKG9,P14174,O43772 3 +Regulation of nitric oxide metabolic process 0.5184463051319053 1.1031912850241272 0.2699441051525015 1.0 0.4490355227294687 10 P30536 1 +Positive regulation of membrane protein ectodomain proteolysis 0.4543066212060722 1.1012034987786483 0.2708080993011723 1.0 0.4502823656763985 3 Q9Y5X1 1 +Positive regulation of cell development 0.3304851396523907 1.1011408742497948 0.2708353499025915 1.0 0.4502823656763985 56 P30536,Q9UQB8,P27695,Q9H2U1,P55209,P78527,Q7L576 7 +Lipid catabolic process 0.3233540497903751 1.0957187199689342 0.2732018878277036 1.0 0.4535965491904876 71 Q9H6V9,P50542,Q8WTV0,Q8NHP8,Q9BWD1,Q8NCC3,P50897,P40939,O15254,Q9UKG9 10 +Positive regulation of nik nf kappab signaling 0.4770309952947006 1.0955929416102004 0.2732569519903047 1.0 0.4535965491904876 12 P61586 1 +Positive regulation of dna methylation dependent heterochromatin assembly 0.5533333566399212 1.094862274827168 0.2735769786851003 1.0 0.4538697022650998 8 Q9Y6X9,P26358 2 +Very long chain fatty acid metabolic process 0.535515400771699 1.0947367087525774 0.2736320014933469 1.0 0.4538697022650998 9 Q15067,P50542 2 +Cdp diacylglycerol metabolic process 0.5860798317139166 1.0934237399061013 0.2742077949648114 1.0 0.4545609697402359 6 O14735,Q6UWP7,Q9HCL2 3 +Response to cocaine 0.5855644570486103 1.0911189845183784 0.2752205302506567 1.0 0.4553143846930678 6 Q00535 1 +Muscle tissue development 0.3396934058836512 1.0907606456099548 0.2753782174024972 1.0 0.45545249799903 52 P16989,P60660,P61586,O95425,P17844,P41440,Q00535,P09493,Q00839,O75844 10 +Regulation of protein maturation 0.5522170131323062 1.08946062406369 0.2759508098369116 1.0 0.4561621189397686 8 Q6P1A2,P35579,Q92896 3 +Toxin transport 0.4963017163949261 1.0891764148233127 0.2760760974449106 1.0 0.4562213784602398 11 P17987,P50991,P49368,Q99832,Q93050 5 +Enzyme linked receptor protein signaling pathway 0.3008558137882103 1.0888909162136156 0.2762019924976404 1.0 0.4562213784602398 105 Q9UQB8,P11717,Q99538,O75131,Q15043,P49815,P08670,Q13526,Q7L576,P17844,Q92896,P27695,P09874,Q99523,Q06481,P31751,P43490,Q9Y4G8,Q9UIQ6,P10586 20 +Regulation of actin filament organization 0.3277947089514442 1.0881593109399692 0.2765247839043359 1.0 0.4562477990450575 63 Q9UQB8,P07737,P21333,O15143,Q9UEY8,O15020,P63167,Q05655,Q8WUW1,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,P09493,Q9Y5X1 17 +Pore complex assembly 0.4756178555041901 1.087335272645866 0.276888665515032 1.0 0.4564331332337243 12 Q92621,Q9BTX1,P49368 3 +Stress fiber assembly 0.4007711143563406 1.0853384770530905 0.2777717701963627 1.0 0.456987850412905 25 P07737,P61586,O95429,P09493 4 +Cell redox homeostasis 0.4704673669041939 1.0847600959928914 0.2780279233694398 1.0 0.456987850412905 13 P27695,P09622,P30044 3 +Leucine metabolic process 0.5395911370691387 1.0822562802106883 0.279138666831864 1.0 0.4582599370982477 5 O15382,Q96RQ3 2 +Sulfur compound catabolic process 0.5674142518156681 1.0816865174145127 0.2793918460785751 1.0 0.4583930236642808 7 Q13867,P15586,P16278,P25325 4 +Diencephalon development 0.5829450885831637 1.079408861231829 0.2804055024396212 1.0 0.4593446838933589 6 P27695,O75569 2 +Positive regulation of epithelial cell migration 0.4050608106520412 1.0779238859307168 0.281067724877569 1.0 0.4601922873059837 24 P07737,Q8WTV0,Q92766,P09601,P09429 5 +Programmed cell death 0.2437539272821476 1.0739408834900246 0.2828491780500841 1.0 0.4621495315463914 399 P30536,Q9BZF9,P11717,P26358,Q9HCL2,P63167,Q9Y6C9,P24390,P09601,Q9NYF8,O15269,O14965,P49773,Q9NS69,Q9NZJ7,Q92542,Q00535,P21796,P49815,O95831,Q9Y6K9,P14174,P98175,Q5JVF3,P00813,P61586,Q15392,P61289,P17844,O75832,P05067,P32929,P27695,P09874,O95197,O43865,O75569,Q99523,P78527,Q99720,P50897,P31751,Q9UHX1,O95429,Q9Y4G8,O75844,Q96QE3,Q96A26,Q86XL3,Q969H8,Q13557,P45880,P46379,P09429,P53634,P52789,Q6PJG6,P30044,O95747,P16989 60 +Response to osmotic stress 0.4186040674239282 1.0737883980383347 0.2829175310331984 1.0 0.4621495315463914 21 P30536,P08183 2 +Negative regulation of proteolysis 0.3263634764689705 1.071114235400218 0.2841180681783388 1.0 0.4636929786260095 63 P46777,Q9UMY4,Q00535,Q9C0C9,O43765,Q5JVF3,Q96KB5,Q9NR09,Q15392,P78318,P19474,P05067,Q92896,Q06481,Q99497,P46379,P30044,Q93009,Q9Y5K5,Q96HY6 20 +Regulation of reactive oxygen species metabolic process 0.3809602218215382 1.0708489121025755 0.2842373700425984 1.0 0.463709631414465 31 P30536,P42785 2 +Protein destabilization 0.4927600287418001 1.0695347829474506 0.2848287642711091 1.0 0.4645461450063675 11 P19474,P78527 2 +Glycerolipid catabolic process 0.5640620477219687 1.0661233939178156 0.2863678657374646 1.0 0.4664669796584637 7 Q8WTV0 1 +Positive regulation of double strand break repair via nonhomologous end joining 0.4934649089046347 1.0652943181044725 0.2867427632058201 1.0 0.4668383716537378 4 P78527,A6NHR9 2 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.4670897792513174 1.0646520953365626 0.2870333958033857 1.0 0.46719187291327 13 O95831 1 +Nucleoside triphosphate metabolic process 0.3512865465083464 1.0629175380420597 0.2878193488817426 1.0 0.4682313236479028 47 P00846,P09874,P00403,P56134,P00813,P61586,P62826,P04818,O00178,P55263,Q96DE0,Q9H773 12 +Foregut morphogenesis 0.4030443414957064 1.0616559963160876 0.2883918827613434 1.0 0.4685192980697029 2 P35222 1 +Neural plate development 0.4030443414957064 1.0616559963160876 0.2883918827613434 1.0 0.4685192980697029 2 P35222 1 +Paraxial mesoderm development 0.4030443414957063 1.0616559963160876 0.2883918827613434 1.0 0.4685192980697029 2 Q8WUM0 1 +Cellular response to calcium ion 0.4711990646052225 1.0615343781343496 0.2884471181007948 1.0 0.4685192980697029 12 Q92542,Q13557,Q99538,O75131 4 +Neurogenesis 0.2557198886291081 1.0610434419643386 0.2886701591190017 1.0 0.46865581899371 252 P30536,Q9UQB8,O14976,Q9H2U1,Q14108,Q86X55,Q9NR77,P55209,O14965,Q9NZJ7,Q92542,Q00535,Q8WUJ1,O94915,P08670,Q13555,Q9UPW6,P61586,Q7L576,P41440,P05067,P27695,P42892,P50897,Q06481,O60828,Q9Y4G8,P50542,P10586 29 +Regulation of actomyosin structure organization 0.4123520846692636 1.0604757645186855 0.2889282099438737 1.0 0.4688275798109548 22 P07737,P61586,O95429,P09493 4 +Negative regulation of dna binding transcription factor activity 0.4076878864956563 1.060445249224954 0.2889420857727378 1.0 0.4688275798109548 23 P21333,P09601,O75832,Q93009,P19474,O15111,Q9UHD1 7 +Regulation of stress activated protein kinase signaling cascade 0.3974844612836656 1.0598361344771363 0.2892191546628504 1.0 0.4690678609433726 25 P36507,P49327,Q96KB5,P43034,P47897,P31689,P27361,P78318,P51452,P09429,P60953,P28482,Q96J02,Q99873,P05067,O75844 16 +Regulation of actin filament bundle assembly 0.407128599809832 1.056285563151262 0.2908377696827993 1.0 0.4707320764206448 23 P07737,P61586,O95429,P09493 4 +Meiotic cell cycle process 0.3692003762241834 1.0557870784656282 0.2910655029722582 1.0 0.4709807374978801 37 Q9Y2W6,Q96KQ7,P46379,Q8IWV8,P42695,Q08J23,O14965,P35579,Q9BTX1,Q6IBW4 10 +Regulation of atp metabolic process 0.3928365557600073 1.048582134117727 0.2943704821116748 1.0 0.4758440448376921 26 P30536,P09874,P61586,P05067 4 +Positive regulation of immune system process 0.2965146326146369 1.047705488402415 0.2947743181150488 1.0 0.4760125929723705 108 O96028,Q9HCL2,Q9H2U1,P09601,Q99538,Q9Y6K9,P14174,Q5JVF3,P00813,P61586,P05067,P04439,Q05655,P78527,Q06481,O60828,Q9NUD5,Q96QE3,P46379,P09429,P53634,O95747 22 +Negative regulation of blood vessel endothelial cell migration 0.5319360637108346 1.0456736685671535 0.2957117239105122 1.0 0.4771626598566174 5 P61586 1 +Negative regulation of catabolic process 0.3005621049476128 1.0444004172956924 0.2963001706423069 1.0 0.4778695469684098 99 P30536,O60506,Q9H2U1,P46777,Q14103,P09601,Q9UMY4,P49815,P21333,O43765,P98175,Q96KQ7,Q96KB5,Q9NNW5,Q13526,Q08J23,O15118,Q08379,Q00839,Q16850,Q92804,P10619,Q99497,P46379,Q08211,Q93009,Q9Y5K5,P16989 28 +T cell activation 0.3410288284107293 1.0403019902938095 0.2981996198128178 1.0 0.4799586689111851 50 P04439,O96005,P17812,Q9HCL2,P00813,P61586,P24390,O14617,P78527,P09429,P35579,Q92542,Q6IBW4 13 +Regulation of dendrite morphogenesis 0.4628598149226984 1.0394994321163018 0.298572522037354 1.0 0.4803616909606481 13 Q9UQB8,Q9Y4G8,O60828 3 +Meiosis i cell cycle process 0.4281574333162393 1.0394378023046789 0.2986011707025677 1.0 0.4803616909606481 19 P46379,O14965,Q8IWV8,Q9BTX1 4 +Regulation of cell morphogenesis 0.322690149164175 1.0387904078989814 0.2989022233889686 1.0 0.4807243248634324 65 Q9P258,Q9UQB8,Q6XZF7,P63167,Q9H2U1,P43034,P61586,P78527,Q92766,P35580,Q7L576,P84095,P35579,P09493,O75844 15 +Morphogenesis of a polarized epithelium 0.4573211296080063 1.0356863755366952 0.3003484805709477 1.0 0.4824399652537134 14 O95487,P43034,P61586,Q13308,P60953 5 +Transition between fast and slow fiber 0.3987425545996135 1.0352660845108648 0.3005446640867686 1.0 0.4825112111481537 2 Q08209 1 +Regulation of cardiac conduction 0.3987425545996115 1.0352660845108514 0.3005446640867748 1.0 0.4825112111481537 2 P20020 1 +Regulation of chromatin organization 0.4340589488440743 1.0344508468910718 0.3009254442678477 1.0 0.4830005363046566 18 Q13263,O60341,P26358,P46013,P24941,Q8NEY8,Q08945,Q66K74,Q15047,Q9UK61,Q00839,Q9Y6X9 12 +Mrna transport 0.2995937715263434 1.0340588683148304 0.3011086435032046 1.0 0.4831725670553822 79 P55735,Q5JVF3,Q13769,Q8NFH4,Q96MU7,Q96PU8,Q08J23,Q5SRE5,Q9BTX1,Q92945,P84103,Q09161 12 +Ammonium ion metabolic process 0.3984116479152966 1.0332379158857006 0.3014925731464979 1.0 0.4834553029394579 2 P49419 1 +Regulation of glucose import 0.5405553213376101 1.033121071010143 0.3015472437373083 1.0 0.4834553029394579 8 Q9BZE9,Q06481,P52789,P31751,Q06124 5 +Response to tumor cell 0.4870356528218178 1.0323071437350753 0.3019282555788289 1.0 0.4837549766723057 4 P04439 1 +Positive regulation of adaptive immune response 0.4513831410747742 1.0314020484476147 0.3023523206545784 1.0 0.4842043259218076 15 P04439,O96028,P00813 3 +Ear development 0.4082991677215223 1.030942985351723 0.3025675572641264 1.0 0.4844129455845812 22 O75569,O95487,P43034,P42892,P63173,P49736,O95747,Q06124 8 +Regulation of phospholipid metabolic process 0.5224495346897464 1.0288440308263125 0.303552972384304 1.0 0.4857458943793143 9 Q8WTV0,Q9UHD1 2 +Regulation of intracellular signal transduction 0.2548501115860762 1.0277608998232963 0.3040623129460313 1.0 0.4864384749773408 259 Q9BZF9,Q8TB61,Q9UMX5,Q9H2U1,P63167,P09601,O14965,Q9UHD1,P49773,P55735,P49815,P61927,Q9Y6K9,O00170,P14174,Q6XZF7,Q5JVF3,P00813,P61586,Q13526,P17844,O75832,P19474,P41440,P05067,P32929,P09874,O75569,Q13769,O15111,Q9NUD5,O95429,Q9Y4G8,O75844,Q96QE3,Q969H8,P45880,Q8IWV8,P09429,Q14137,Q10713,P16989 42 +Sprouting angiogenesis 0.4607981941104117 1.0272540458996546 0.3043008550157173 1.0 0.4866975929743078 13 P61586 1 +Hindbrain development 0.3696726444993408 1.0263036939154957 0.3047484566605294 1.0 0.4872908655432263 33 O15228,P27695,O15020,O14949,O95487,P12277,P63167,Q5KU26,Q14103,Q9UKA9,Q06124,Q92542,Q00535 13 +Response to iron ion 0.5709006112686807 1.0256573434148104 0.3050531276780224 1.0 0.4876553519923316 6 P09601 1 +Regulation of ossification 0.5389606673263724 1.0254316651764537 0.3051595534901903 1.0 0.4877028217208071 8 Q06124,O95747,P28482,O75844 4 +Fatty acid derivative metabolic process 0.4259146253758812 1.0242225154631548 0.3057301863602073 1.0 0.4883770760852002 19 Q8WVX9,Q13085,P35610,P50897,Q9UMR5,P35914,Q92947,Q14914,Q53GQ0,Q9NZ01 10 +Chondrocyte differentiation 0.5215291479823636 1.0242120801137549 0.3057351141823492 1.0 0.4883770760852002 9 Q15043,Q92896 2 +Negative regulation of reproductive process 0.5704379559167151 1.023596228093222 0.3060260275444175 1.0 0.4887189525307331 6 P00813 1 +Positive regulation of jnk cascade 0.5270092892744127 1.0221715923936476 0.3066996934607644 1.0 0.489271617403967 5 P09429,P05067 2 +Regulation of inflammatory response to antigenic stimulus 0.5269838905792493 1.022050531189736 0.3067569847946521 1.0 0.489271617403967 5 Q99497,Q15046 2 +Interferon alpha production 0.5378718774306527 1.020183863619706 0.3076412690441288 1.0 0.4900265052722714 8 Q9H2U1,Q7Z434,Q08211,O15111 4 +Positive regulation of interferon alpha production 0.5378718774306527 1.020183863619706 0.3076412690441288 1.0 0.4900265052722714 8 Q9H2U1,Q7Z434,Q08211,O15111 4 +Regulation of skeletal muscle tissue development 0.5692912844532627 1.018489142286927 0.3084455581586853 1.0 0.4907873189504184 6 P16989 1 +Carbohydrate catabolic process 0.3443668634812992 1.0184052825389371 0.308485392804112 1.0 0.4907873189504184 48 Q9NUJ1,Q14108,P05067 3 +Proteoglycan metabolic process 0.5692683890657767 1.0183871891411975 0.3084939878872079 1.0 0.4907873189504184 6 Q7LGA3,Q99805 2 +Proteoglycan biosynthetic process 0.5692683890657767 1.0183871891411975 0.3084939878872079 1.0 0.4907873189504184 6 Q7LGA3,Q99805 2 +Purine nucleobase biosynthetic process 0.502347933580283 1.0182282697233906 0.3085694877318845 1.0 0.4907873189504184 10 P00813,P34896 2 +Homeostatic process 0.2550647737279997 1.0177940338076084 0.3087758479485354 1.0 0.4907873189504184 274 P30536,Q6P1A2,Q9HCL2,Q8WTV0,Q9Y6C9,P42785,P09601,Q9UHD1,Q92542,Q00535,Q15043,Q93050,P14174,P00813,P09622,Q9HD20,P30519,P05067,O15118,P27695,Q8N511,P09874,Q9Y487,Q9BZE9,P78527,P50897,Q06481,O15260,P40939,P13473,P61916,Q9HC07,Q13557,Q86XI2,Q9UIQ6,Q15067,P09429,P52789,P30044,O15254 40 +Cardiac chamber morphogenesis 0.5371012534172622 1.0164707551941126 0.3094052669852969 1.0 0.4916449692396368 8 O96028,P09493 2 +Regulation of dna methylation dependent heterochromatin assembly 0.5198403404543812 1.0157168509077397 0.3097642412710968 1.0 0.4918770209770028 9 Q9Y6X9,P26358 2 +Negative regulation of cardiac muscle tissue growth 0.4389275074478727 1.015183508112344 0.3100183604778781 1.0 0.4918770209770028 3 P49840,P11413 2 +Regulation of cell growth involved in cardiac muscle cell development 0.4389275074478727 1.015183508112344 0.3100183604778781 1.0 0.4918770209770028 3 P49840,P11413 2 +Negative regulation of cell growth involved in cardiac muscle cell development 0.4389275074478727 1.015183508112344 0.3100183604778781 1.0 0.4918770209770028 3 P49840,P11413 2 +L serine metabolic process 0.4834927058120689 1.014159420958317 0.3105066880678226 1.0 0.4922874805086258 4 P34896 1 +Cellular response to ketone 0.4308355585830787 1.013119481397141 0.3110030940261294 1.0 0.4928286376539713 18 O95831,Q13085,O43823,P11802,Q99497,Q9H4A6,P62873 7 +Protein maturation by iron sulfur cluster transfer 0.4829004047656816 1.01112788228553 0.3119552269456733 1.0 0.4937219677456922 4 Q9H3K6,Q96T76 2 +Cellular response to alcohol 0.4478047960916498 1.0092759680360022 0.3128423021804432 1.0 0.494226974258426 15 O95831 1 +Ear morphogenesis 0.4529416071988573 1.009163199067986 0.3128963726267946 1.0 0.494226974258426 14 O75569,O95487,P63173,Q13308,P28482,O95747,Q8IZL8 7 +Maintenance of apical basal cell polarity 0.436941410129092 1.0041094895516869 0.3153258419014282 1.0 0.4974462772711633 3 O75083,Q8WUM4 2 +Negative regulation of platelet derived growth factor receptor signaling pathway 0.4369414101290897 1.0041094895516738 0.3153258419014344 1.0 0.4974462772711633 3 Q07954,O14964 2 +Sulfur compound transport 0.5340513877628069 1.001785603734546 0.3164471516985871 1.0 0.498720083361324 8 Q9UBX3,Q70HW3 2 +Cellular response to reactive oxygen species 0.3829597127200621 1.0010387404989267 0.3168080793626555 1.0 0.499165134464313 29 P27695,O95831,Q05655,P63244,Q99720,P30044,O15111,P09493 8 +Regulation of myeloid leukocyte mediated immunity 0.5493369120446567 0.9979313773282829 0.3183126355565053 1.0 0.5006669417463866 7 P09601 1 +Positive regulation of reactive oxygen species biosynthetic process 0.4796147870012433 0.994324468696563 0.3200649269417075 1.0 0.5032985343002209 4 P00403 1 +Negative regulation of protein localization 0.3651986997052225 0.9934670154936572 0.3204824170609748 1.0 0.5036523688334104 34 P49257,Q16836,Q16850,P31689,O95429,P40939,Q9BRK4,Q99497,Q9UHD1,Q10713,Q06124,Q9UMY4,Q00535 13 +Muscle structure development 0.2985475609986129 0.9909444457073712 0.3217127079981552 1.0 0.5052646335646835 93 Q00839,Q53GG5,Q8IV08,P32929,P60660,P26358,Q99523,P61586,O95425,P17844,P41440,Q00535,P09493,P16989,O75844 15 +Regulation of t cell apoptotic process 0.5203337960252579 0.9903917161690398 0.3219826928423828 1.0 0.5054914375108317 5 P00813 1 +Positive regulation of embryonic development 0.5316683767805609 0.990323183386746 0.3220161784898296 1.0 0.5054914375108317 8 P43034,O95747,P63244,Q68CQ4 4 +Smad protein signal transduction 0.531328057446439 0.988687116821656 0.3228162480131384 1.0 0.5066222400917304 8 Q9UIQ6,P08670 2 +Vascular endothelial growth factor production 0.3904698874917379 0.984653754569293 0.3247941757299979 1.0 0.5083456737108759 2 P38398 1 +Regulation of cell matrix adhesion 0.4263713544759978 0.983628972863585 0.325297974253373 1.0 0.5090088440065088 18 P61586,P63167 2 +Viral life cycle 0.2973243850449181 0.9826833198702962 0.3257633226332426 1.0 0.5096115379416416 88 O75531,Q8WTV0,Q14108,P19474,O15118 5 +Metanephric renal vesicle morphogenesis 0.3898080741231056 0.98061391744271 0.326783168514309 1.0 0.5103277196749259 2 P35222 1 +Positive regulation of mesenchymal cell proliferation 0.3898080741231056 0.98061391744271 0.326783168514309 1.0 0.5103277196749259 2 P35222 1 +Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 0.3898080741231056 0.98061391744271 0.326783168514309 1.0 0.5103277196749259 2 P35222 1 +Metanephric nephron morphogenesis 0.3898080741231056 0.98061391744271 0.326783168514309 1.0 0.5103277196749259 2 P35222 1 +Mesenchymal to epithelial transition involved in metanephros morphogenesis 0.3898080741231056 0.98061391744271 0.326783168514309 1.0 0.5103277196749259 2 P35222 1 +Signal transduction by p53 class mediator 0.3534115842119932 0.9788595746036644 0.3276493688458608 1.0 0.511303557177582 42 P61927,P14174,P46379,P17844,O75832,O14965,Q14137,P49773,O75844 9 +Cellular component morphogenesis 0.2806582640521556 0.9777209016334976 0.3282123811891981 1.0 0.5120564297590927 123 Q9UQB8,Q9H2U1,P61586,Q9NR77,P42892,Q06481,Q7L576,O14965,P41440,O60828,P05067,P09493,Q9Y4G8 13 +Positive regulation of chromatin binding 0.431976166832169 0.9764689550099348 0.3288321250796215 1.0 0.5126458148163048 3 P56545,O60341 2 +Membrane lipid biosynthetic process 0.4046462071404898 0.974148826642739 0.3299826490154427 1.0 0.5140612051819005 21 Q05655,Q99805,Q06136,Q8NBX0,O15269 5 +Negative regulation of protein polymerization 0.3800760041151833 0.9738676108997318 0.3301222774402261 1.0 0.5141127632249687 27 P07737,Q05655,O15020,Q9UEY8,P45880,O95425,Q13045,Q9BTW9 8 +Positive regulation of mitochondrial membrane potential 0.474816834302836 0.969830110176261 0.3321311815884833 1.0 0.5165220920421825 4 P31751 1 +Positive regulation of membrane potential 0.474816834302836 0.969830110176261 0.3321311815884833 1.0 0.5165220920421825 4 P31751 1 +Regulation of immune response 0.2887074318065383 0.9647022956976276 0.3346939450770383 1.0 0.5199987081177354 112 O96028,Q9Y6K9,P04439,O75531,P46379,P00813,Q5KU26,P78527,Q9NZ08,P09601,Q06481,Q14166,P19474,P41440,O60828,Q9NUD5,Q96QE3 17 +Snrna modification 0.4289970208540221 0.9599183270903834 0.3370963215961653 1.0 0.5228365593131349 3 O60832,Q9NX24 2 +Regulation of atp biosynthetic process 0.5547712310821832 0.9540030886353656 0.3400820789561269 1.0 0.526496797038454 6 P09874,P00403 2 +Ensheathment of neurons 0.388693333203487 0.95399278888985 0.3400872925624116 1.0 0.526496797038454 24 Q9NR77,Q96PU8,Q7L576,P53634,Q92542 5 +Macrophage activation 0.5397226218224905 0.9536030957449094 0.3402845881425376 1.0 0.526496797038454 7 P05067,P14174 2 +Forebrain development 0.3173645633625471 0.9517618128431516 0.3412177928101019 1.0 0.5275554101437625 56 P27695,Q9Y5K5,O14949,O75569,Q9UPW6,P63167,P43034,P50542,P61586,P62826,A0AVT1,Q96N66,P05067,Q00535,Q9Y4G8 15 +Maturation of lsu rrna 0.3804009123821826 0.9509350133826072 0.3416373663937182 1.0 0.5278506092276292 26 Q9Y4W2,P55769,O00541,Q14137,Q5SY16 5 +Alpha beta t cell activation 0.4381790528278003 0.9499439833497282 0.3421407164489343 1.0 0.5284681394287792 15 P09429,P04439,P61586,P00813 4 +Myoblast fusion 0.5535052264309586 0.94839896242688 0.3429263874464412 1.0 0.5293681668756415 6 P41440 1 +Syncytium formation 0.5535052264309586 0.94839896242688 0.3429263874464412 1.0 0.5293681668756415 6 P41440 1 +Purine nucleobase metabolic process 0.4707889694108345 0.9482364453689596 0.3430090972700919 1.0 0.5293681668756415 11 P00813,P34896 2 +Positive regulation of g1 s transition of mitotic cell cycle 0.4516647735972126 0.9479908908085868 0.3431340915590195 1.0 0.5293681668756415 12 Q96DY7 1 +Microtubule bundle formation 0.4474055146891442 0.9479795916525668 0.3431398438526813 1.0 0.5293681668756415 13 Q9UHD1,A0AVF1,Q66K74 3 +Negative regulation of cellular component organization 0.2754868956066256 0.9476576553973992 0.3433037644480503 1.0 0.5294925325968959 163 P30536,O14976,P63167,P43034,Q86X55,Q9NR77,Q96DY7,Q9NYB0,Q00535,P49815,P07737,P21333,Q9UEY8,P08670,O95104,Q5JVF3,Q96KQ7,P61586,O75832,P05067,Q9BTW9,Q00839,P09874,O15020,Q05655,O95425,Q99497,Q9UHV9,Q99536,Q9P258,Q9Y4G8,P50542,P45880,Q13045,P09429,Q9UIG0 36 +Positive regulation of production of molecular mediator of immune response 0.4006148369188192 0.9455040334925352 0.3444016125703837 1.0 0.5306707029084506 21 Q9H2U1,O96028,P04439,P14174 4 +Synaptic vesicle endosomal processing 0.5107378112244898 0.944864094408498 0.3447282645033434 1.0 0.5308081195556591 5 Q4V328 1 +Establishment of protein localization 0.2515723503486335 0.9445561223306836 0.3448855368783612 1.0 0.5308408164746871 485 P30536,P84085,A6NIH7,Q99595,P43034,Q14108,P24390,P63244,Q9NT62,Q9NS69,P55786,Q9UMY4,Q9Y2T2,P55735,O95831,P21333,O60830,Q15154,Q13555,O43765,Q9HD20,Q709C8,O60725,Q96D46,Q96ED9,Q9H267,O15118,Q08379,Q53H12,O43865,Q9BZH6,P00367,Q99523,Q16850,O15260,P10619,Q9Y5J9,Q8N1F7,Q99497,Q9BXS5,Q9NVG8,O95429,Q9UBQ0,Q9UBV2,Q9Y512,O00410,O43823,P46379,P55072,P98194,Q9Y5L4,Q9Y282,O43681,O60220,Q5SRE5,Q9Y584,P49815,Q5JVF3,Q9Y4I1,Q5JRX3,P27695,Q8IYI6,P50897,Q06481,P40939,Q96KP1,P49257,P50542,Q8NFH4,Q9BTX1,Q9BZL1,Q10713,O96028,Q99797,P43307,Q9UHD1,Q00535,O00170,Q9UI26,P35580,Q9UFC0,Q96T51,Q9BZE9,Q4V328,P31751,P13473,Q9Y3B3,P52789,A0AVF1,P49458,Q9NV70,Q99747,Q92621,Q15388,P35579,P62826,P49368,Q92973,Q05655,O15027,O14617,P53985,Q99570,Q9P258,Q9Y5X1,O95487,Q8NFH3,Q96L92,Q9H4A6,Q9H9E3 110 +Regulation of establishment of planar polarity 0.5525652287675491 0.9442400990719592 0.3450469683237189 1.0 0.5308928905024346 6 P60953,P61586,O95487 3 +Gtp biosynthetic process 0.4695364238410443 0.9429398769003058 0.3457116565094398 1.0 0.5316581874604402 4 P12268,P22392,P15531 3 +Response to virus 0.2920686062212524 0.942441984860422 0.3459664004323648 1.0 0.5318195108383338 84 Q9Y6K9,O75569,O75531,Q9HCL2,Q9H2U1,Q7Z7L1,Q15366,P19474,O60828,O15111,P61916,Q9NUD5,Q09161,O75844 14 +Regulation of adaptive immune response 0.4071328584273589 0.9421688704627516 0.3461061888020764 1.0 0.5318195108383338 20 O96028,P00813,P04439,Q96QE3 4 +Inositol phosphate mediated signaling 0.5101497403266054 0.9420808550078568 0.3461512454905895 1.0 0.5318195108383338 5 Q9UHD1 1 +Calcineurin mediated signaling 0.5101497403266054 0.9420808550078568 0.3461512454905895 1.0 0.5318195108383338 5 Q9UHD1 1 +Negative regulation of phagocytosis 0.5518775124924223 0.9411985982400404 0.3466030949590184 1.0 0.5323850342096474 6 P09429,P63244 2 +Toll like receptor signaling pathway 0.4502431075443905 0.9397704010191514 0.3473353444816207 1.0 0.5333808769087175 12 Q06481,Q5KU26,P41440 3 +Cell migration 0.2617018137972745 0.9338695276415638 0.3503711992354328 1.0 0.5373936636921841 198 P30536,P63167,Q8WTV0,P43034,P63244,P42785,P09601,Q99538,P35579,O75131,Q00535,P07737,P21333,P14174,Q9UPW6,P00813,P61586,P84095,Q5SNT2,P05067,P09493,P27695,Q05655,O95684,Q06481,P31751,Q96N66,O95429,Q9UH99,Q9Y4G8,Q9P258,P50542,Q92766,P09429,Q6PJG6,O95747,Q9H4A6,P10586 38 +Pattern specification process 0.3809310506027519 0.9319785472757616 0.3513476122658892 1.0 0.5387612602079593 25 Q9Y2W6,O75569,Q9UPW6,P78527,O14965,O95747,Q9UK61 7 +Necrotic cell death 0.4242402031465681 0.9306629884935866 0.3520279206729919 1.0 0.5394140462385576 17 P30536,P16989 2 +Forelimb morphogenesis 0.5075557303321887 0.9298141982466416 0.3524672937209763 1.0 0.539957126751151 5 O94788,O95747,P35222 3 +Response to mineralocorticoid 0.5342991578239022 0.9286834593923918 0.3530531552707678 1.0 0.5407243023857832 7 P09874,O95831 2 +Cation transmembrane transport 0.2874238574606616 0.9248876119285556 0.3550243711395806 1.0 0.5426475131111217 110 P00846,P27695,P00403,Q9HC07,Q9UHD1,O43772,Q13423,Q9HD20,P31930,Q9Y619,Q15043,P05067,Q9UDW1,Q70HW3,P21796 15 +Intracellular protein transport 0.2509237518846735 0.9248845555485712 0.3550259611375155 1.0 0.5426475131111217 302 P30536,Q99595,Q14108,Q99797,Q9Y282,O43681,O60220,Q5SRE5,P43307,Q9UHD1,Q9NS69,Q9Y584,P55786,Q00535,P55735,P49815,O95831,O60830,O00170,Q9UI26,Q5JRX3,O60725,P27695,O43865,Q9BZH6,Q99523,Q9BZE9,Q06481,O15260,P10619,Q9Y5J9,Q4V328,P31751,P13473,O95429,P49257,P50542,P46379,Q9BZL1,Q9Y5L4,Q10713 41 +Dna deamination 0.465894039735084 0.9244371269732152 0.3552587720820361 1.0 0.5427944123445725 4 Q5RKV6,Q9NPD3,Q9NQT4 3 +Transcription coupled nucleotide excision repair 0.4656063463631578 0.9229774049641982 0.3560189803020916 1.0 0.5436945311869521 4 Q93009 1 +Heart morphogenesis 0.3795720632007142 0.9215399179533744 0.3567686103773431 1.0 0.5447084524521721 25 O96028,P21333,O95487,P10253,P63167,P49840,P60953,Q96T37,P09493,O75844 10 +Heart process 0.3730895058166095 0.9183179067396912 0.3584524551672685 1.0 0.5464926981175996 27 P00813,P09493 2 +Cerebral cortex neuron differentiation 0.4638783809856613 0.9142154307880171 0.360603657505218 1.0 0.5492443918291795 4 P50542 1 +Regulation of reactive oxygen species biosynthetic process 0.4994993443040775 0.913884946473783 0.3607773044127476 1.0 0.5493408602303362 9 P61586,P00403,Q9BSK2 3 +Somatic diversification of immunoglobulins 0.3961077004247897 0.9135704904353796 0.3609425782567501 1.0 0.5493408602303362 21 O96028,Q9UQ84,P78527,Q9Y3Z3,Q12888,Q96FZ2,Q96QE3 7 +Pigment granule maturation 0.4205861463668643 0.9133504171281662 0.3610582740589949 1.0 0.5493408602303362 3 O14617 1 +Pigment accumulation 0.4205861463668643 0.9133504171281662 0.3610582740589949 1.0 0.5493408602303362 3 O14617 1 +Monocyte differentiation 0.5309374511612153 0.9132726995775082 0.3610991368852021 1.0 0.5493408602303362 7 Q13769,P35579 2 +Sulfur compound metabolic process 0.2928859295823429 0.9122709818519608 0.3616260859827087 1.0 0.5498593908305295 94 Q16775,P15586,O43865,Q8TB61,Q9HCL2,P50897,P09622,Q9UMR5,P16278,O60725,Q9UBX3,Q13126,P32929 13 +Regulation of protein catabolic process in the vacuole 0.42036535617888 0.9121314689737732 0.361699514327005 1.0 0.5498593908305295 3 P04062 1 +Regulation of lysosomal protein catabolic process 0.42036535617888 0.9121314689737732 0.361699514327005 1.0 0.5498593908305295 3 P04062 1 +Positive regulation of cellular carbohydrate metabolic process 0.463384871987137 0.9117147696562126 0.3619188869281196 1.0 0.5499298219734946 4 P61964,P31751 2 +Positive regulation of glucose metabolic process 0.463384871987137 0.9117147696562126 0.3619188869281196 1.0 0.5499298219734946 4 P61964,P31751 2 +Chromosome organization involved in meiotic cell cycle 0.4152711731404758 0.9106271079746776 0.3624918824054424 1.0 0.5502742786169076 18 P42695,P46379,Q9BTX1,Q96KQ7 4 +Regulation of golgi to plasma membrane protein transport 0.5033579148192602 0.9100010987863144 0.3628219303102602 1.0 0.5505123392341881 5 P63244 1 +Nuclear transcribed mrna catabolic process exonucleolytic 0.4309965107222265 0.9058906275493078 0.3649937455994123 1.0 0.5525509582953048 15 Q969T7 1 +Pteridine containing compound metabolic process 0.4203620936913603 0.905822479377848 0.3650298207733522 1.0 0.5525509582953048 17 P34896,P04818,P35270,P41440,Q9H2D1 5 +Ceramide metabolic process 0.4258430978282059 0.9058129889243012 0.3650348448524205 1.0 0.5525509582953048 16 Q05655,Q99805,P06280,Q8NCC3,O15269 5 +Regulation of response to interferon gamma 0.4190665342601725 0.9049647883551644 0.3654840417202878 1.0 0.5530991831367021 3 Q15648,Q16543 2 +Negative regulation of single stranded viral rna replication via double stranded dna intermediate 0.5022007091023581 0.904547908046778 0.3657049429708414 1.0 0.5533017418525752 5 Q9UK61,Q9Y6X9 2 +Arachidonic acid metabolic process 0.5019689911334019 0.9034564323103214 0.3662837010833764 1.0 0.5539136816764074 5 P07099 1 +Terpenoid metabolic process 0.4079705415567865 0.9031340091268316 0.3664547761482082 1.0 0.5540405702183662 19 P48449,Q9HB40 2 +Cell cell signaling 0.272410072392345 0.901872946286799 0.3671243641092214 1.0 0.5547889819967217 166 P49815,Q9UQB8,P25398,P27695,P14174,Q13555,Q9NPI1,P61586,Q9NR77,Q9UIQ6,P50897,Q92542,Q7L576,P41440,P43490,P05067,Q9Y4G8 17 +Carbohydrate derivative metabolic process 0.2487173828205963 0.9013287526709648 0.367413550576096 1.0 0.5548033031143034 248 P15586,P00403,Q8TB61,Q9HCL2,Q9NUJ1,Q9NPH0,Q9H773,P49773,Q9UHD1,Q92542,Q13126,P00813,P61586,Q7LGA3,Q2TAA5,Q10472,Q8NBX0,P04818,P09622,P55263,O60725,O60502,Q86YN1,P05067,P84090,O15118,Q9BV10,P09874,Q99805,P32321,P50897,Q96DE0,Q9NZ01,Q9UKG9,P00846,Q9HC07,Q9UMR5,P16278 38 +Negative regulation of response to dna damage stimulus 0.3740285998511033 0.901198114282202 0.3674829934095684 1.0 0.5548033031143034 26 Q9BRJ7,Q13769,O75832,P14174 4 +Urogenital system development 0.3466858906226381 0.8999880235483173 0.3681266242421461 1.0 0.5553792603093001 41 P07602,P61586,O75844 3 +Negative regulation of response to stimulus 0.2456390193692567 0.8973492007255639 0.3695326102921195 1.0 0.5572358887346883 220 Q6P1A2,Q9UMX5,P09601,Q9UHD1,P49815,P14174,P00813,P61586,Q13526,P61289,O75832,Q14166,P19474,Q92896,Q9BRJ7,P32929,P04439,Q13769,Q06481,Q15366,O75531,P45880,Q8IWV8,P80303,Q6DKJ4,Q10713,P16989 27 +Negative regulation of inflammatory response to antigenic stimulus 0.4174114531611976 0.8958422679962267 0.370337011558487 1.0 0.5578986843932247 3 P25786,P28070 2 +Positive regulation of cell cycle 0.2917289499479248 0.8958051747568121 0.3703568256485594 1.0 0.5578986843932247 89 P27695,Q5JVF3,Q13769,P61586,O95425,Q96DY7,O75832,O14965,P19474,Q96DE0,Q8IY18,P05067,Q00839 13 +Regulation of actin filament based process 0.2898374227201214 0.8938032008733127 0.3714271962900459 1.0 0.5591843854700742 86 Q9UQB8,P63167,Q8WUW1,Q96F07,P35579,Q00535,P07737,P21333,Q9UEY8,O15143,P61586,Q7L576,P84095,P09493,Q05655,O95425,O95429,Q9Y5X1,Q13557,Q13045 20 +Positive regulation of small molecule metabolic process 0.4381093942564595 0.8933112669087679 0.3716905059803963 1.0 0.559428097563675 13 P00403,P55072,P31751,Q99497,P05067 5 +Nuclear pore complex assembly 0.4950280403118002 0.8916506848638759 0.3725801940584192 1.0 0.560634401854951 9 Q92621,Q9BTX1 2 +Embryonic organ development 0.3293766740966624 0.8911793717660778 0.3728329491224507 1.0 0.5607986210066848 49 Q03164,Q9BYW2,Q13308,P60953,O94788,P27635,Q9UPW6,P00813,Q9NR09,Q12830,O75569,Q13769,P63173,P42892,Q68CQ4,Q8IZL8,Q7Z6E9,O95487,Q9ULT8,Q07864,P28482,O95747,P19447,P27361 24 +Regulation of immune system process 0.2697162330774292 0.890438835849298 0.3732302970739125 1.0 0.5612140449968744 174 O96028,Q9HCL2,Q9H2U1,P09601,Q9Y6K9,P14174,Q5JVF3,P00813,P61586,Q5KU26,Q14166,P19474,P41440,P05067,P04439,O96005,P78527,Q9NZ08,Q06481,O60828,Q9NUD5,Q9GZP4,Q96QE3,O75531,P46379,P09429,P53634 27 +Ovarian follicle development 0.4590059470590266 0.8895624418888078 0.3737008807501365 1.0 0.5615231201058789 4 P49770 1 +Segmentation 0.4598281621238621 0.8882341131228519 0.3744148325280862 1.0 0.5623300273035247 11 Q9Y2W6,Q9UK61,O95747,P78527 4 +Focal adhesion assembly 0.4229607325936173 0.8878091781066992 0.3746434050810296 1.0 0.5625403927935329 16 P61586,P63167 2 +Regulation of cytoplasmic translation 0.4278725828597077 0.8868003024220199 0.375186424777981 1.0 0.5629567790105873 15 Q00839,Q9H2U1,Q08211,Q14103,P16989 5 +Protein neddylation 0.5394655218279951 0.8864944842919321 0.3753511250725316 1.0 0.5630709820535783 6 Q9BTE7,P46777,Q8TBC4 3 +Positive regulation of transporter activity 0.4053320872923699 0.8854530213771511 0.3759123465088796 1.0 0.56351388547416 19 Q03164,P27695,Q05655,P08183,Q9UHD1,Q00535 6 +Dna dependent dna replication 0.3074682684190716 0.8844388502138325 0.3764593586256226 1.0 0.5640678178746953 69 Q9Y619,Q7Z7L1,Q14566,Q9NR33,Q9NRL2,P46063,Q9UFC0,P41440,Q9NRF9,P09884,P35250,O75844,Q96QE3 13 +Regulation of cyclic nucleotide phosphodiesterase activity 0.4568116735823184 0.8784876305872893 0.3796791474469037 1.0 0.5682224302266352 4 O00170,Q15043 2 +Cellular response to chemical stress 0.2881075068452762 0.8764651578437826 0.3807772097569706 1.0 0.5694635165212483 79 P30536,P27695,O95831,P09874,Q99720,P09601,P09493,P16989 8 +Cell cycle dna replication initiation 0.5370295368204212 0.8758046871761791 0.3811362215205225 1.0 0.5697323198458234 6 P33991,P09884 2 +Negative regulation of cell morphogenesis involved in differentiation 0.4136714500082135 0.8752712286263441 0.3814263450104471 1.0 0.5700319418966381 3 Q9P258 1 +Response to ph 0.4958041045823858 0.8744777306861551 0.3818581425879053 1.0 0.5702406526274865 5 Q9UHD1 1 +Plasma lipoprotein particle clearance 0.4572962450693598 0.8744380436547882 0.3818797469408073 1.0 0.5702406526274865 11 Q8WTV0,P09601,Q9Y2B0 3 +Olefinic compound metabolic process 0.4095406519281346 0.8731647861818147 0.3825732655062097 1.0 0.5710746067537503 18 Q6NUM9,Q15185,P07099 3 +Signal transduction in response to dna damage 0.3419070095761702 0.870300425490362 0.3841362464794966 1.0 0.5731384935736339 42 P14174,Q13769,P78527,P17844,O75832,O75844 6 +Locomotor rhythm 0.4549668874172045 0.8691907970490208 0.3847427802582746 1.0 0.5739087330020167 4 P54802,Q13330,O75376 3 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.5061245725136765 0.8682971280335652 0.385231694002037 1.0 0.5745032020358863 8 P46379,P14174 2 +Oocyte differentiation 0.5058532793088643 0.867011213278084 0.3859358658062324 1.0 0.5752833872102282 8 Q9Y2W6 1 +Dendrite morphogenesis 0.376999638718555 0.8662317075561561 0.3863631085303165 1.0 0.5757852093361528 24 Q9H2U1,Q9UQB8,Q9Y4G8,O60828 4 +Regulation of protein localization to chromatin 0.4542462397687417 0.86556268378536 0.3867300268485945 1.0 0.5761969176393967 4 P55072 1 +Positive regulation of erk1 and erk2 cascade 0.429007972650428 0.865330492014865 0.3868574194128027 1.0 0.5762173741917984 14 P05067,P14174 2 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.50535718086997 0.8646603817440185 0.3872252205381836 1.0 0.576472665525218 8 P46379 1 +Positive regulation of attachment of spindle microtubules to kinetochore 0.454047889822582 0.8645644494018804 0.3872778920378668 1.0 0.576472665525218 4 Q00839 1 +Uv protection 0.4529801324503167 0.8591934739408501 0.3902337832738505 1.0 0.5804647616402108 4 P39748,P19447,Q9BRK5 3 +Transcription elongation from rna polymerase i promoter 0.4529801324503153 0.8591934739408424 0.3902337832738547 1.0 0.5804647616402108 4 O15160,P19447,Q9GZS1 3 +Meiotic cell cycle 0.3181553528843525 0.8589240108122286 0.3903824414056234 1.0 0.580550022829701 52 Q9Y2W6,P46379,Q96CW5,Q8IWV8,Q9UQ84,P42695,Q08J23,O14965,P35579,Q9BTX1,Q9UH99 11 +Dna biosynthetic process 0.3083036172555924 0.8581873329650296 0.3907890294120242 1.0 0.5810052149059532 63 P04183,P28340,Q9UPR3,Q9NRG0,Q9NR33,P04818,P35250,Q14103,P49368,P55072,Q9BRT9,Q07864,P09884,P41440,Q9NRF9,Q9NYB0,Q15185,Q00839 18 +Glial cell development 0.3949000394553233 0.8580382372941632 0.3908713497384921 1.0 0.5810052149059532 20 Q92542,Q00535,P05067,P08670 4 +Histone h3 k4 demethylation 0.4523399353152684 0.8559754162358884 0.3920113776449367 1.0 0.5825635530304462 4 Q9H6W3,Q8NB78 2 +Cardiac chamber development 0.4224955414187257 0.8540543990201696 0.3930748487711 1.0 0.5834618726737767 15 O96028,P43243,P49840,Q96T37,P09493,O75844 6 +Ketone biosynthetic process 0.4495750804112151 0.8420971556564883 0.3997335732507587 1.0 0.5911369454587767 4 Q14849 1 +Cellular carbohydrate metabolic process 0.3075466691633768 0.8414358809262784 0.4001037914605687 1.0 0.5915468012382821 56 Q9NUJ1,Q7LGA3,Q14108,P08236,P35573,P52789,P16278,P31751,Q15185,Q10713,O75844 11 +Genitalia morphogenesis 0.3663136995367369 0.838430449462199 0.401788994096443 1.0 0.593624092625986 2 P35222 1 +Purine containing compound biosynthetic process 0.2961331461292268 0.8381565570128422 0.4019427822695709 1.0 0.5936990645400709 76 P00846,P09874,P00403,P00813,P50897,P09622,Q9UMR5,P55263,Q13126 9 +Regulation of transporter activity 0.3414256464974236 0.8380073893112117 0.402026553458223 1.0 0.5936990645400709 40 P27695,Q05655,Q13557,O43865,O95747,P08183,Q9UHD1,P05067,Q00535 9 +Regulation of response to cytokine stimulus 0.3914177479948881 0.8342548241757405 0.4041374030134119 1.0 0.5961237720012175 20 P43034,Q08211,Q9Y3Z3,Q14166,Q99943,Q06124 6 +Oogenesis 0.4277973224264141 0.8331222931250475 0.4047757618719778 1.0 0.5966941942144156 13 Q9Y2W6,O14965,Q96MU7,O60879 4 +Negative regulation of viral genome replication 0.4314616413850259 0.8319480729672477 0.4054382553577169 1.0 0.5974463163326166 12 Q96SB4,O75531,Q15047,Q9UK61,Q9Y6X9 5 +Alpha beta t cell differentiation 0.4666060221521083 0.831831612348831 0.4055039975863606 1.0 0.5974463163326166 10 P00813 1 +Low density lipoprotein particle clearance 0.4661559452946334 0.8295139692912411 0.4068136354789067 1.0 0.598888491841684 10 Q8WTV0,P09601,Q9Y2B0 3 +Innate immune response 0.2747648035117319 0.8232196185107029 0.4103831143635483 1.0 0.6036554211744304 119 P10321,Q9H2U1,Q9Y6K9,P14174,P08670,Q5KU26,Q14166,P19474,P04439,P78527,Q9NZ08,Q06481,Q15366,O15111,O60828,Q9NUD5,O43823,P68371,O75531 19 +Hormone mediated signaling pathway 0.341058203566412 0.8229454174696046 0.4105390335433199 1.0 0.6037450479410784 39 P09874,P61586,Q86X55,P42785,Q06481,Q15185 6 +Positive regulation of nucleotide biosynthetic process 0.4453577892839278 0.8209931887665672 0.411650147940128 1.0 0.6049182795547835 4 P00403 1 +Positive regulation of atp biosynthetic process 0.4453577892839278 0.8209931887665672 0.411650147940128 1.0 0.6049182795547835 4 P00403 1 +Ectoderm development 0.4031777557100264 0.8179132547873239 0.4134067211787435 1.0 0.6070892761515646 3 P35222,P13693 2 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.4954246960588102 0.8177820189070266 0.4134816671586097 1.0 0.6070892761515646 8 Q92896 1 +Reactive oxygen species metabolic process 0.3373356031742472 0.8134311823155221 0.4159708873027865 1.0 0.6105123367748556 41 P30536,P00403,P61586,Q13423,Q15067,P42785,P52789 7 +Negative regulation of cellular catabolic process 0.2858238770609059 0.8133056607033101 0.4160428323435772 1.0 0.6105123367748556 89 P30536,O60506,Q9H2U1,P46777,Q14103,P09601,P49815,O43765,P98175,Q96KQ7,Q96KB5,Q9NNW5,Q08J23,O15118,Q08379,Q00839,Q92804,P10619,Q99497,P46379,Q08211,Q93009,Q9Y5K5,P16989 24 +Regulation of smooth muscle cell differentiation 0.5226568893995182 0.813102176790146 0.4161594785283142 1.0 0.6105123367748556 6 P26358 1 +Striated muscle cell proliferation 0.4021442646980934 0.8122962119103738 0.4166216836671519 1.0 0.6108017194361911 3 P06493 1 +Cellular response to steroid hormone stimulus 0.321467391252214 0.8106826852183812 0.4175479192412961 1.0 0.6117848730119501 49 O95831,P09874,P61586,Q86X55,P17844,Q15185,O15118 7 +Amide transport 0.343523492554006 0.810518361145504 0.4176423165511094 1.0 0.6117848730119501 35 Q13555,P07602,P40939,P08183,P41440,Q9H2D1 6 +Xenobiotic metabolic process 0.4233290584005404 0.8072197896089043 0.4195398662223102 1.0 0.6138736749920782 13 O43169,O00170,P07099 3 +Glycosphingolipid metabolic process 0.4931712544088096 0.8072001641290572 0.419551171202893 1.0 0.6138736749920782 8 P16278,Q05655,Q99805 3 +Endosome organization 0.3618421037454975 0.8068846750739944 0.4197329287977642 1.0 0.6139260611413555 26 Q14108,Q96ED9 2 +Intrinsic apoptotic signaling pathway 0.2982382460658792 0.8065607726037698 0.419919581619288 1.0 0.6139886958298124 74 O95831,P09874,P14174,O75569,P45880,P46379,P09601,P49773,P16989 9 +Regulation of nik nf kappab signaling 0.4096982500107734 0.80555365130061 0.4205002593156728 1.0 0.6145791040506632 16 P61586 1 +Nucleobase catabolic process 0.4008606421714622 0.8053283867165492 0.4206302050155002 1.0 0.6145791040506632 3 Q16555,Q02252 2 +Pyrimidine nucleobase catabolic process 0.4008606421714622 0.8053283867165492 0.4206302050155002 1.0 0.6145791040506632 3 Q16555,Q02252 2 +Positive regulation of inflammatory response 0.4614210517890986 0.8051898287411275 0.420710145016431 1.0 0.6145791040506632 10 P53634,P05067,Q08211 3 +Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.3606882859033829 0.8048467425398715 0.4209081244504538 1.0 0.6147270310218483 2 Q92783 1 +Positive regulation of cell cycle process 0.2979902933157811 0.8034736299912849 0.4217010324444257 1.0 0.6154607949981101 74 P27695,Q5JVF3,Q13769,P61586,O95425,Q96DY7,O14965,Q96DE0,Q8IY18,P05067,Q00839 11 +Response to catecholamine 0.4139142782953556 0.8021340743392184 0.4224754063532416 1.0 0.6158838721975238 15 P05067 1 +Regulation of establishment of protein localization to mitochondrion 0.409052697107346 0.8015777444723804 0.4227972557090704 1.0 0.61592925906185 16 P55786,P49257,O95429 3 +Axis specification 0.4918060927841631 0.8007999778581258 0.4232474518426461 1.0 0.616443813911975 8 Q9Y2W6,O14965 2 +Regulation of fatty acid oxidation 0.4798175484300024 0.7999539890639941 0.4237374556164042 1.0 0.6168747750567717 5 Q06481 1 +Ventricular septum development 0.5056800852116998 0.7985755937510831 0.4245365441940021 1.0 0.6176901316343917 7 O96028,Q13308,Q96T37,P43243 4 +Response to hepatocyte growth factor 0.5186294534563695 0.7956587784144452 0.4262303924195294 1.0 0.6193746825539038 6 Q06481 1 +Positive regulation of stress activated protein kinase signaling cascade 0.4907068082529575 0.7956521518969866 0.4262342450426015 1.0 0.6193746825539038 8 Q99873,P09429,P05067 3 +Muscle hypertrophy in response to stress 0.3988745448526922 0.794566857397375 0.4268655037184872 1.0 0.6201502038022182 3 P02545,Q08209 2 +Somatic diversification of immune receptors via somatic mutation 0.5181844790691754 0.7937352834710603 0.4273495550109345 1.0 0.6205697444938313 6 Q9Y3Z3,Q9UQ84 2 +Regulation of fatty acid transport 0.4783446291126482 0.7931396534175815 0.427696462066411 1.0 0.6208191386846328 5 P14174 1 +Positive regulation of locomotion 0.2964449416395773 0.7931050051030403 0.4277166469949665 1.0 0.6208191386846328 75 P07737,Q8WTV0,Q9Y6A4,P61586,Q92766,O95429,P09601,P09429,Q99538,P31751,O95747,P05067,Q9UH99,Q9Y4G8 14 +Positive regulation of neuron death 0.3970169375336981 0.7919843133463185 0.4283698229327783 1.0 0.6214833587219217 18 P09874,P61586,O95831 3 +Membrane repolarization 0.5041533056028785 0.791715618018474 0.428526513600046 1.0 0.6215688088639645 7 P21333,O75844,P05023 3 +Amine biosynthetic process 0.477888178756998 0.791029884707926 0.428926552589598 1.0 0.6220071111703137 5 P52788 1 +Monocarboxylic acid biosynthetic process 0.3418312750736358 0.790383160248439 0.4293040337148912 1.0 0.6222705674553817 34 Q8IVS2,P14174,Q9BZF3,O95864,Q96PU8,Q9NZ01,Q15185 7 +Anterior posterior axis specification 0.5032435464814612 0.7876325800714499 0.4309116518777567 1.0 0.6242402357633394 7 Q9Y2W6,O14965 2 +Tail anchored membrane protein insertion into er membrane 0.4738734727152843 0.787465666529297 0.4310093192752129 1.0 0.6242402357633394 9 P46379 1 +Regulation of t cell activation 0.3471708601681339 0.7871267617287446 0.431207664728646 1.0 0.6243179765410648 31 P04439,O96005,Q9HCL2,P00813,P61586,P09429 6 +Dephosphorylation 0.2780351554119427 0.7858918667977036 0.43193083980232 1.0 0.6250802408432482 80 Q69YH5,Q86XL3,Q05655,Q01968,Q9Y217,Q13555,P05023,P63167,Q13526,Q5TFE4,Q969T7,Q9NPH0,Q96DE0,Q9UHD1,Q10713,Q9H857,O95429,P10586 18 +Regulation of muscle hypertrophy 0.4573077216620944 0.7841496406908419 0.432952310525456 1.0 0.6261141782424896 10 P49840,P09874,Q13557 3 +Central nervous system neuron development 0.4225295797424643 0.7813033320482511 0.4346241108459909 1.0 0.6275490341974371 12 Q00535,O14949,Q9Y4G8 3 +Negative regulation of neuron death 0.3350159954474626 0.7797119850410507 0.4355604227151246 1.0 0.628615360303663 40 Q9Y6K9,Q9UMX5,P61586,P50897,P09601 5 +Regulation of muscle organ development 0.4872302422991821 0.7794073751689815 0.4357397807222618 1.0 0.6287314520478312 8 P16989 1 +Er associated misfolded protein catabolic process 0.514682903096334 0.7786261109650932 0.4361999932852622 1.0 0.6291098609759761 6 P46379,P55072 2 +Metal ion homeostasis 0.2959525194185535 0.778167074433783 0.4364705245876157 1.0 0.6293412404793768 74 P27695,Q8N511,Q9HC07,Q13557,Q9Y487,P09601,P09429,Q9HD20,P30519,P05067,Q00535,Q15043 12 +Somatic diversification of immune receptors 0.3580778970119179 0.7780179125933903 0.43655845331554 1.0 0.6293412404793768 26 O96028,Q9UQ84,P78527,Q96QE3 4 +Protein kinase a signaling 0.5143979127116991 0.7773985507498395 0.436923667233168 1.0 0.629724904520185 6 P14174 1 +Biological adhesion 0.2675444719214483 0.774012738959908 0.438923257975466 1.0 0.6316970985936421 149 Q9UQB8,Q15417,Q9HCL2,Q8WTV0,P63167,Q99797,P35579,Q00535,P00813,P61586,P35580,P41440,P05067,P09493,Q9BTW9,P04439,Q05655,O14617,O95429,Q92766,P09429,P10586,Q69YQ0 23 +Anterior head development 0.3553937789543421 0.7734484180123544 0.4392570447146409 1.0 0.6319415518800945 2 Q13206 1 +Positive regulation of glycoprotein metabolic process 0.4999905235149389 0.7730618257958978 0.4394857918855166 1.0 0.6319845459783583 7 Q9UHD1,Q92542,Q08379 3 +Positive regulation of cell projection organization 0.3014870666650421 0.7723212597280907 0.4399241768235129 1.0 0.6323288258458273 58 Q9UQB8,P07737,P27695,Q9H2U1,Q8NCA5,Q14108,Q92766,Q7L576,Q9Y4G8 9 +Embryonic pattern specification 0.4995198072352224 0.7709572573808839 0.4407322669561144 1.0 0.6332039531584682 7 Q9Y2W6,Q9UPW6 2 +Auditory receptor cell development 0.5127755792431906 0.7704169217770365 0.441052618761109 1.0 0.6334487813147032 6 O95487 1 +Peptidyl tyrosine modification 0.3379789828184016 0.7689274860820736 0.4419363593410099 1.0 0.6339649778522352 36 Q05655,P14174,Q86XI2,Q96KB5,O95684,Q9UIG0,P05067 7 +Dicarboxylic acid transport 0.4079995052258345 0.7666276395453598 0.4433029372816386 1.0 0.6356042114509576 15 Q9H2D1,P41440 2 +Regulation of tor signaling 0.4079151553226333 0.7661231141096713 0.4436030509477744 1.0 0.6358910671682576 15 P49815,P55735,O75844 3 +Cardiac septum morphogenesis 0.4340031920195861 0.7646089221394755 0.4445044546879899 1.0 0.6368959229028097 4 O96028 1 +Positive regulation of multicellular organism growth 0.5113197334191728 0.7641611385430483 0.4447712219175068 1.0 0.6371345247932553 6 P50542 1 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4158037255783249 0.7638787106377349 0.4449395253908803 1.0 0.6372320016639107 13 Q9H2U1,Q08211,Q00839,Q14103 4 +Deoxyribonucleotide biosynthetic process 0.4836886216454655 0.7629166933283726 0.4455130799405531 1.0 0.6379096949993592 8 P34896,P04818,P55263,P32321 4 +3 utr mediated mrna destabilization 0.5109838965343139 0.7627193238644713 0.445630803647584 1.0 0.6379345468432531 6 Q9H2U1,Q92945 2 +Skeletal muscle contraction 0.4716793640278394 0.7624281945066103 0.4458044840728119 1.0 0.6380394732643081 5 Q99622,P28161,P10253,P78417 4 +Regulation of lipase activity 0.4186990947197114 0.7597389476772674 0.4474106430253217 1.0 0.6395873840979871 12 Q99523,P61586 2 +T cell lineage commitment 0.4710646516050363 0.7596065734384094 0.4474897887167635 1.0 0.6395873840979871 5 P61586 1 +Regeneration 0.3389450339590988 0.7585742302686067 0.4481072929531902 1.0 0.6401820530479831 32 P30536,P11717,P09601,O14965,P10586 5 +Blastocyst growth 0.482597359407377 0.7578478225829984 0.4485420894357175 1.0 0.6406592180794203 8 Q92541,Q86XI2 2 +Myotube differentiation 0.3968872854742233 0.7572956756876899 0.4488727410479187 1.0 0.6409874504831659 17 Q99523,Q8IV08 2 +Ossification 0.2999246116705511 0.7570428903345536 0.4490241669949086 1.0 0.6410596597977627 56 P49327,Q9UPW6,Q9H2U1,Q99523,P61586,Q15125,Q08211,P17844,O95747,P67936,Q9H6W3,Q00839,O75844 13 +Mitochondrial protein processing 0.5095205696109388 0.756442656233668 0.449383841178383 1.0 0.6414290802896481 6 Q10713 1 +Regulation of cation channel activity 0.4060284402084213 0.7548521781606694 0.450337682203709 1.0 0.6420471320405534 15 P27695,P05067,Q00535 3 +Protein insertion into er membrane 0.4176599176603541 0.7539061511543346 0.4509055767740064 1.0 0.6424469504540652 12 P46379 1 +Tetrahydrofolate interconversion 0.5088054057329137 0.7533784997772585 0.4512224988922504 1.0 0.6427544157236987 6 P34896,P04818 2 +Embryonic digit morphogenesis 0.4694020157694229 0.7519843784312644 0.4520604532004499 1.0 0.6433601282049547 5 P42892 1 +Process utilizing autophagic mechanism 0.2660554287819157 0.7510381076599353 0.4526297220473079 1.0 0.6436050365397514 139 P30536,O00267,P09601,O15269,Q9NZJ7,Q00535,P21796,P49815,Q93050,Q9Y6K9,Q96KQ7,Q9NNW5,P07602,P19474,Q66K74,O15118,P27695,Q8IYI6,O15027,Q9Y487,P10619,P13473,O75844,P09429,P52789,Q9NV70 26 +Gliogenesis 0.3105508484986758 0.7507763334607411 0.4527872747647525 1.0 0.6436850633873333 51 P30536,P08670,P61586,P05067,P31751,Q92542,Q00535 7 +Peptidyl serine modification 0.2993118003752545 0.7503158421847622 0.4530645034764125 1.0 0.6439351485009118 56 P09874,Q13557,P14174,Q10472,P78527,O95429,P31751,O14965,O15111,P05067,Q00535 11 +Regulation of g protein coupled receptor signaling pathway 0.4169297465916047 0.7498123797961209 0.4533677116366104 1.0 0.6442220378185325 12 P00813 1 +Negative regulation of nuclear division 0.3902469880398051 0.7485808687266615 0.4541098665762126 1.0 0.6445561214735167 18 Q96DY7 1 +Negative regulation of camp dependent protein kinase activity 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.6448204531322685 2 P10644 1 +Gamete generation 0.2809213410814317 0.7473694386204135 0.4548405878201944 1.0 0.6451610748014184 96 P25440,P11717,Q6IBW4,Q9H2U1,Q14141,O14965,Q96KQ7,P62826,P09622,Q08J23,O75718,Q99598,Q96PU8,Q9GZP4,Q9Y2W6,P46379,Q8IWV8,Q96MU7,Q15067,A0AVF1,Q9BTX1,P16989,O60879 23 +Amyloid beta metabolic process 0.4163854381085778 0.7467631720666676 0.4552065296388432 1.0 0.6452224655864345 12 P27695,Q13526,Q92542 3 +Regulation of mesenchymal cell proliferation 0.3899371069182361 0.7464569331452056 0.4553914381089907 1.0 0.6452224655864345 3 P02545,P35222 2 +Anterior posterior pattern specification 0.3999782912202019 0.7460121271995889 0.4556600892774347 1.0 0.6454418648091438 16 Q9Y2W6,P78527,O95747,O14965,Q9UK61 5 +Positive regulation of smoothened signaling pathway 0.4301744548028977 0.7457566556339942 0.4558144277396962 1.0 0.6454418648091438 4 Q8NCM8,Q9Y5K5 2 +Response to leukemia inhibitory factor 0.3421316154996545 0.7456962364958347 0.4558509331542237 1.0 0.6454418648091438 31 P23378,O15382,P52789,P84103,Q00839,P32929 6 +Receptor mediated endocytosis 0.3072955321485076 0.7446065554548206 0.4565096038017042 1.0 0.6462305215509203 52 O14976,Q5VW38,Q14108,P50897,P41440,P05067 6 +Response to nitrosative stress 0.4666816819169075 0.7395441093812755 0.4595766656427331 1.0 0.6488381356786344 5 Q99497 1 +Cerebral cortex radially oriented cell migration 0.4921569321849663 0.7381713762477993 0.4604103144748337 1.0 0.6495822328084446 7 P43034,Q00535,Q96N66 3 +Telencephalon glial cell migration 0.4921569321849663 0.7381713762477993 0.4604103144748337 1.0 0.6495822328084446 7 P43034,Q00535,Q96N66 3 +Regulation of stem cell differentiation 0.4030654951481979 0.7372084633245009 0.4609955874755402 1.0 0.650119359661534 15 Q9H2U1,Q9Y6C9,Q08J23,P78527 4 +Positive regulation of cell population proliferation 0.2699448043816079 0.7341594223138824 0.4628515810201075 1.0 0.6523025829188034 118 P30536,P26358,Q9HCL2,Q8WUW1,Q86X55,P11802,Q9BSK2,P55209,P09601,Q99538,P43307,P14174,P00813,P62753,P84095,Q00839,P04439,P11047,Q8NCA5,O43663,O95684,P31751,P43490,Q96QE3,Q969H8,Q15022,Q99873,Q08211,Q92766,P09429,O95747,Q86Y37,Q96HY6 33 +Regulation of gene expression by genomic imprinting 0.387166088317443 0.7316551392712531 0.4643790841610622 1.0 0.654165216960929 3 P38398 1 +Retinal metabolic process 0.3869579609400793 0.73054574293667 0.4650566630584247 1.0 0.6545394487155332 3 Q8TC12,O94788 2 +Post translational protein modification 0.4133436715592792 0.7297637156530238 0.4655346270033464 1.0 0.6550670996752868 12 O60725,O75718,Q9HA64 3 +Homologous chromosome pairing at meiosis 0.4763313307998185 0.7288611656863562 0.4660865918534012 1.0 0.6555535246338167 8 P46379,Q9BTX1 2 +Cell activation 0.2680513242603834 0.7279415479484523 0.4666493682830914 1.0 0.6561998638954268 120 O96028,P17812,Q9HCL2,P24390,P09601,P35579,Q92542,P21333,P14174,Q5JVF3,P00813,P61586,P62753,P05067,P04439,O96005,Q05655,O14617,P78527,Q96QE3,P46379,Q9UQ84,P09429,P53634,Q96L92,Q6IBW4 26 +Neuron projection organization 0.369257305149083 0.7261929612854147 0.4677204863566202 1.0 0.6574151727737015 21 Q9H2U1,Q9UQB8,P05067 3 +Sodium ion transmembrane transport 0.3916778841137722 0.7248830592032685 0.4685237745764006 1.0 0.6582531191882409 17 Q13557,Q6P4Q7,P05023,P27105,Q92581,O95747,Q9UHD1 7 +Regulation of membrane protein ectodomain proteolysis 0.4256917746226833 0.7237988855166747 0.4691892136598312 1.0 0.658896739288972 4 Q9Y5X1 1 +Regulation of cell substrate junction organization 0.3962103818081047 0.7231340275158337 0.4695975455365193 1.0 0.6593244973338009 16 P61586,P63167 2 +Regulation of sodium ion transmembrane transport 0.4282276949009996 0.7183882176410676 0.4725179496321781 1.0 0.6624005487124225 11 Q13557,P46939,P27105,O95747,Q9UHD1 5 +Cell death in response to hydrogen peroxide 0.4868209856944391 0.71457832335459 0.4748696430147774 1.0 0.6653223464263445 7 P63244,Q99720 2 +Dopamine biosynthetic process 0.3836477987421351 0.71294702949961 0.4758785358126776 1.0 0.6656434801112189 3 P05091,Q99497 2 +Catechol containing compound biosynthetic process 0.3836477987421351 0.71294702949961 0.4758785358126776 1.0 0.6656434801112189 3 P05091,Q99497 2 +Protein localization to chromosome centromeric region 0.4067676804469333 0.7123751354966746 0.4762325083726932 1.0 0.6659920403117356 13 P50748,Q96DY7,P06493,Q8IY18,Q9P258 5 +Positive regulation of nf kappab transcription factor activity 0.3467273803665707 0.7121956219394513 0.4763436476482026 1.0 0.6660009292679225 27 P60900,Q9Y6K9,P19474,P41440,P05067,P32929 6 +Response to growth factor 0.278967310954811 0.7117289193554959 0.4766326560313318 1.0 0.6662584477095108 91 Q9UQB8,P27695,P09874,Q99523,O95429,Q7L576,P05067,Q9Y4G8,Q92896 9 +Cerebellar cortex formation 0.423080094719339 0.7110662353997049 0.4770431920096669 1.0 0.6666856922632901 4 Q06124,Q00535 2 +Phosphatidylinositol phosphate biosynthetic process 0.4854315892114177 0.7084596953467042 0.4786598328887348 1.0 0.6685040425930122 7 Q99570,P42356,Q01968,O00443 4 +Smooth muscle cell differentiation 0.4850782191519931 0.7069052003147743 0.4796253920808238 1.0 0.6697054024748937 7 P26358 1 +Barbed end actin filament capping 0.4088669585373347 0.704875797763525 0.4808875328506772 1.0 0.6710035641901209 12 P35611,Q9UEY8,O95425,Q13045 4 +Regulation of cell cell adhesion 0.3265684570863094 0.7038466442909238 0.4815282820606792 1.0 0.6713300637810214 40 P04439,Q05655,Q9HCL2,P00813,P61586,P09429,P41440 7 +Spindle assembly 0.3123924376859143 0.6976134654623356 0.4854189582360155 1.0 0.6758648189590613 48 O94927,P21333,P07437,Q08379,O43663,P61586,Q8WUX9,Q96CW5,Q9BRK4,O14965,Q96CS2,Q9H6D7,Q00839 13 +Small gtpase mediated signal transduction 0.2761446858014553 0.6968757204722686 0.4858805735301246 1.0 0.6760632498593414 87 P49815,Q6XZF7,P26358,Q96T51,P63167,P61586,Q15392,Q92766,P80303,P09601,Q7L576,P41440,Q9UHD1,Q9Y4G8 14 +Appendage development 0.4001416458023077 0.6959637451275343 0.4864515347908944 1.0 0.6767095546357901 14 P42892,O75569 2 +Cell cycle process 0.2394021610145754 0.6952092351446097 0.4869241855967208 1.0 0.6769225992241377 332 P43034,Q96DY7,Q69YH5,P21333,Q15154,P61586,P62753,P05067,Q08379,Q13769,P33991,P46013,Q96DE0,Q9H6D7,O75844,Q9Y2W6,O43823,O75531,P07437,P46379,P55072,Q07864,P08183,Q86Y37,Q96HY6,O94927,P11802,P50748,P60953,Q14141,Q07666,Q12888,Q6DKK2,Q96JB5,Q5JVF3,Q9NR09,Q08J23,Q96CS2,O95785,O94966,P83731,P27695,Q9NPI1,Q14566,O95425,P78527,Q8WUX9,Q06481,Q9BRK4,P09884,Q9ULW0,Q06124,Q9NQG5,Q9UH99,O43159,Q86XL3,Q86XI2,P23246,Q8IWV8,P49736,Q9BTX1,Q9Y619,Q6NUQ1,Q53EZ4,Q9BTE3,Q15005,P42695,O14965,Q9UHD1,Q00535,Q9NNW5,Q13526,P61289,P35580,Q8IY18,Q7Z7L1,Q00839,Q96QE3,Q96CW5,Q8NBT2,Q9UIG0,Q9BV86,P35579,Q96KQ7,Q14807,P62826,Q9H4L7,O43663,P53985,Q8N6R0,Q99570,Q9P258,Q9Y5X1,P30260,Q6IBW4 95 +Regulation of supramolecular fiber organization 0.2776668869207293 0.6948153154363027 0.4871710488900533 1.0 0.6771176878952939 92 Q9UQB8,P63167,Q8WUW1,Q96F07,P07737,P21333,Q9UEY8,O15143,P61586,Q7L576,Q66K74,P05067,P09493,Q9BTW9,Q05655,O15020,O95425,Q99497,Q9UHV9,O95429,Q9Y5X1,Q13045 22 +Positive regulation of protein serine threonine kinase activity 0.3494483858505309 0.6939840523454124 0.4876922101491272 1.0 0.6775457240891481 25 P61586,P14174 2 +Positive regulation of ion transmembrane transport 0.3604096128010997 0.6888385527983052 0.4909248714662295 1.0 0.6813108300489884 22 Q9UHD1,P27695,P08183 3 +Ameboidal type cell migration 0.2910109867903329 0.6874365114744356 0.491807696044066 1.0 0.6823684165151896 69 P07737,Q8WTV0,P61586,Q92766,P42785,P09601,Q06481,P09429,Q99538,Q5SNT2,O95429 11 +Regulation of signal transduction by p53 class mediator 0.3301785775595265 0.6856405605106761 0.4929397975689842 1.0 0.6836407055091563 32 P61927,P14174,P17844,O75832,O14965,Q14137,O75844 7 +Erk1 and erk2 cascade 0.3296560617829375 0.6836788585346145 0.4941779763250253 1.0 0.6849095546275319 33 P05067,P14174 2 +Dna templated transcription termination 0.4516749937624426 0.6805278734242096 0.496170278939668 1.0 0.6866946805733893 9 Q08211,O75844 2 +Bergmann glial cell differentiation 0.4536316341934774 0.6804457559013465 0.4962222573746975 1.0 0.6866946805733893 5 Q06124,P28482,P08670 3 +Hydrogen peroxide metabolic process 0.4515063503450307 0.6797271819033108 0.496677221478468 1.0 0.6870251185456241 9 P30044,P00403,Q99497,Q15067 4 +Amp metabolic process 0.3932422609069269 0.679254605521415 0.4969765537084811 1.0 0.6871400860063316 15 P00813 1 +Multi multicellular organism process 0.3511007857021577 0.6759181608161386 0.499092606629687 1.0 0.6899157476594803 24 Q9BQE5,Q9UIQ6,P41440 3 +Activation of innate immune response 0.3731630743694267 0.6739589743044593 0.5003373966624536 1.0 0.6908851820957104 19 Q8WXF1,P23246,Q15233,Q7Z434,P78527,P43243,P09429,O60828,Q9NUD5 9 +Meiotic chromosome condensation 0.489900514450223 0.67327422517711 0.5007728473284994 1.0 0.6911861493202914 6 P42695 1 +Response to oxidative stress 0.2761205347113651 0.6729362176408812 0.5009878695797534 1.0 0.6913328048304196 91 O43169,O95831,P27695,P09874,Q15392,Q15165,Q99720,P09601,P30519,P28074,P05067,P09493 12 +Macromolecule deacylation 0.3276837477079582 0.6705619870979883 0.5024996053286781 1.0 0.6925168021398695 34 Q9NUJ1,Q9UMR5,O43823,P50897 4 +Regulation of neural precursor cell proliferation 0.3992195327850221 0.6698731097008275 0.5029386829306803 1.0 0.6928214713280026 13 Q06481,P61586,P55209 3 +Response to alkaloid 0.3913460044569737 0.6681719708605292 0.5040238250173541 1.0 0.6931383557701507 15 Q00535,P31930 2 +Molting cycle 0.4342612101182824 0.668144843803355 0.5040411391393387 1.0 0.6931383557701507 10 O75844 1 +Cell activation involved in immune response 0.3266240109920266 0.6659466154687282 0.5054452233267916 1.0 0.6943180980041253 35 O96028,P00813,Q9UQ84,P09601,P05067,Q96QE3 6 +Cell projection assembly 0.2750570430663321 0.6633671793582007 0.5070954207153591 1.0 0.6962839693382636 95 A6NIH7,P63167,Q8WUW1,Q9NR77,Q14141,Q9NT62,P07737,P21333,Q7L576,P84095,P27695,Q05655,Q9BZH6,Q8NCA5,Q9Y6A4,O95429,Q9P258,Q9Y4G8,Q01968,A0AVF1,Q9H4A6 21 +Biological process involved in symbiotic interaction 0.2882296244788018 0.6592524081590028 0.5097336979979286 1.0 0.6987875161644024 70 Q8WTV0,O15118,Q14108,P19474 4 +Negative regulation of jnk cascade 0.4864790329267862 0.6589806459289667 0.5099081969745907 1.0 0.6987875161644024 6 P51452,P43034,P31689 3 +Regulation of dna methylation 0.4165983695733236 0.6575296980078523 0.5108403817225391 1.0 0.6994617548962642 11 P09874,O75844,Q96KQ7 3 +Cellular response to corticosteroid stimulus 0.4000460460347015 0.6563380369619298 0.5116066489810489 1.0 0.7002092723780248 12 O95831,Q00839 2 +Response to estrogen 0.3998767577142779 0.6554135180609513 0.5122015503375796 1.0 0.7002317714432581 12 O15143,Q9H7N4,P04062,P38398,P09601,Q14258,Q8IZL8 7 +Skin epidermis development 0.4315545223702747 0.6547659809181234 0.5126184366292663 1.0 0.7002317714432581 10 O75844 1 +Long chain fatty acyl coa biosynthetic process 0.485460473839071 0.6547388263230502 0.512635922699407 1.0 0.7002317714432581 6 Q53GQ0,Q9NZ01 2 +T cell receptor signaling pathway 0.3645669268531772 0.6543858802566894 0.5128632288900308 1.0 0.7002317714432581 20 P04439,Q9Y6K9,P00813,P49770,Q07666,Q9NR50,Q13144 7 +Antigen receptor mediated signaling pathway 0.3645669268531772 0.6543858802566894 0.5128632288900308 1.0 0.7002317714432581 20 P04439,Q9Y6K9,P00813,P49770,Q07666,Q9NR50,Q13144 7 +Sodium ion transport 0.3643209006605678 0.6527735747621963 0.5139022619119795 1.0 0.7007858349522725 20 Q6P4Q7,O43865,Q13557,P05023,P27105,Q92581,O95747,Q9UHD1 8 +Positive regulation of organ growth 0.4109548290525778 0.6525939236996979 0.5140181038937295 1.0 0.7007934509542137 4 O00763,P16989 2 +Regulation of chromatin assembly or disassembly 0.388419647089849 0.651141243131395 0.5149553151528767 1.0 0.701469349145239 15 Q13263,O60341,P26358,P24941,Q8NEY8,Q66K74,Q15047,Q9UK61,Q9Y6X9 9 +Amyloid beta formation 0.4305277978640949 0.6497063625216689 0.5158819132896453 1.0 0.7020245041133351 10 P27695,Q13526,Q92542 3 +Regionalization 0.3693661019957298 0.6496549759292505 0.5159151130763668 1.0 0.7020245041133351 19 Q9Y2W6,P78527,O95747,O14965,Q9UK61 5 +Regulation of glucose transmembrane transport 0.430000364791568 0.6471105675561435 0.5175603864225029 1.0 0.7036607093265088 10 Q9BZE9,Q06481,P52789,P31751,Q06124 5 +Negative regulation of lipid metabolic process 0.4444392641454974 0.6463566908957533 0.5180483814490193 1.0 0.7040229874898368 9 O00763,Q8NF37,Q06481,P05023 4 +Cell morphogenesis involved in neuron differentiation 0.2722637795696273 0.6447745170794308 0.5190733181407916 1.0 0.7048130762877315 87 Q9UQB8,Q9H2U1,P42892,Q06481,Q7L576,P41440,O60828,P05067,Q9Y4G8 9 +Positive regulation of endothelial cell migration 0.378573139227322 0.6445068207997845 0.5192468360648146 1.0 0.7048980969730801 17 Q8WTV0,P09429,P09601 3 +Telomere maintenance 0.2898509891300684 0.6438779620046968 0.519654573513658 1.0 0.705300975710615 59 P27695,P09874,Q9H2U1,Q9UQ84,P49750,Q14103,P78527,P41440,Q8IY18,Q15185,Q00839 11 +Defense response to other organism 0.2599209024960139 0.6425957945690078 0.5204864125868083 1.0 0.706164142397661 151 P10321,Q9HCL2,Q9H2U1,Q9Y6K9,P14174,P08670,Q5KU26,Q14166,P19474,Q7Z7L1,Q09161,P04439,P78527,Q9NZ08,Q06481,Q15366,O15111,O60828,Q9NUD5,O75844,O43823,P68371,O75531,P62888,P09429 25 +Nucleotide transmembrane transport 0.4285739626583237 0.6401020059897846 0.5221062849545128 1.0 0.7077218057519479 10 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Regulation of protein deacetylation 0.4131558492450091 0.6397321281500189 0.5223467643725395 1.0 0.7077459037202858 11 O43823,Q86XI2 2 +Folic acid metabolic process 0.4693242198278898 0.6383503680615286 0.5232456314196927 1.0 0.7085107015985443 7 Q9H2D1,P34896,P41440 3 +Regulation of phosphatidylinositol 3 kinase signaling 0.4558456557529858 0.6357147831734395 0.5249623391571547 1.0 0.7100788737354492 8 P49815,Q10713 2 +Regulation of chemotaxis 0.3452866041724562 0.6342850238612083 0.5258948283423024 1.0 0.7106872514391358 24 P09429,O95747,P14174 3 +Icosanoid biosynthetic process 0.4552186539147778 0.6329082219951612 0.5267935782982627 1.0 0.7116471803748688 8 Q15185,P14174 2 +Nucleoside monophosphate biosynthetic process 0.3448817765484893 0.6314048392443433 0.5277758526662266 1.0 0.7126283784398177 24 P00813,P04818,P55263,P32321 4 +Regulation of protein targeting 0.348312556728158 0.629426910704577 0.5290696047212431 1.0 0.7139631438658643 23 P49257,P55786,Q9BZL1,Q9UHD1,O95429,Q00535 6 +Positive regulation of chromatin organization 0.4104877917234275 0.6260132527886976 0.5313062487065849 1.0 0.7163730413192733 11 Q9Y6X9,P26358 2 +Positive regulation of fat cell differentiation 0.4409479443381936 0.6240586549314704 0.5325890652065306 1.0 0.7177981548881909 5 Q86X55,Q00839 2 +Digestive tract morphogenesis 0.366434955312805 0.622989987831262 0.5332911012725339 1.0 0.718591952446094 3 Q9HCM4,P35222 2 +Regulation of chromatin binding 0.4406319178952917 0.6226685569777842 0.5335023493022202 1.0 0.7187242331845933 5 Q08209 1 +Regulation of rac protein signal transduction 0.3661039390930114 0.6212885788385314 0.5344097669957037 1.0 0.7194891927610025 3 P50570,O15294 2 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.4523713348628359 0.6201999094949315 0.5351261810962065 1.0 0.7201675828331102 8 P14174 1 +Sodium ion import across plasma membrane 0.3285903375248254 0.6185322307227471 0.5362245586218783 1.0 0.7210161401736109 2 Q92581 1 +Negative regulation of developmental growth 0.4088768789668885 0.6177629352706828 0.5367316192170732 1.0 0.7213927197597204 11 P49840,Q99538,Q00535 3 +Dna strand elongation 0.3691670507422772 0.6162982962804158 0.537697663108712 1.0 0.7223856154552892 18 P33991,Q9NRF9,P09884,Q9Y5K5 4 +Intraciliary transport 0.463821650093018 0.6147839386112725 0.5386974176615047 1.0 0.7232701281488222 7 O43805,A0AVF1 2 +Regulation of protein tyrosine kinase activity 0.4079746610570178 0.6131532812802868 0.5397749925637205 1.0 0.7244108641754661 11 Q86XI2,O95684,P63244,Q99816,P05067 5 +Central nervous system neuron differentiation 0.3733093255861541 0.6127616063379872 0.5400339807625683 1.0 0.7246054426275879 17 O14949,P50542,Q9UPW6,Q00535,Q9Y4G8 5 +Endothelial cell proliferation 0.3854031526096305 0.6121941121655607 0.540409336629847 1.0 0.7248030689215674 14 Q8WTV0,P09601,Q969H8 3 +Ribose phosphate metabolic process 0.2574038010768145 0.6102371371959852 0.5417047322874575 1.0 0.7260808263220329 136 P00846,P09874,P00403,Q8TB61,P00813,P61586,P50897,P09622,Q9UMR5,P55263,Q96DE0,P49773,P05067,Q9UKG9 14 +Binding of sperm to zona pellucida 0.4071943681491217 0.609173083446481 0.5424097194842137 1.0 0.726719261602374 11 P45880,P49368,P17987,Q99832 4 +Sperm egg recognition 0.4071943681491217 0.609173083446481 0.5424097194842137 1.0 0.726719261602374 11 P45880,P49368,P17987,Q99832 4 +Regulation of cysteine type endopeptidase activity 0.3051418767675661 0.6085916743997166 0.5427951243229967 1.0 0.7270823625283386 47 Q9BZF9,Q96A26,O95831,P49327,P63167,Q5JVF3,P61586,Q15392,P63244,P78318,P09429,P30044,Q99538,Q96F07,Q99497,Q9NZJ7 16 +Negative regulation of intracellular transport 0.3769386113409224 0.6083023971301453 0.5429869314625966 1.0 0.7271860380059553 16 P49257,O95429,Q9UHD1,Q9UMY4,Q00535 5 +Blastocyst formation 0.3845526746050379 0.60743162332252 0.5435645072842958 1.0 0.7278061951335547 14 P00813 1 +Negative regulation of histone h3 k4 methylation 0.4007307458215968 0.6042162338142363 0.5456998893032123 1.0 0.7292826947878926 4 P61964,P38398 2 +Homologous chromosome segregation 0.421145615990063 0.6038884299399073 0.5459178216154197 1.0 0.7294205747714121 10 P46379,Q9BTX1 2 +Long chain fatty acid metabolic process 0.3478473260168366 0.602801723441039 0.5466406001174857 1.0 0.7300793558198654 22 Q15185,Q96PU8,P07099 3 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.2840696161559865 0.601287089577676 0.5476487870366276 1.0 0.7308116083150965 68 P49815,Q9UQB8,Q99523,Q7L576,Q9Y4G8,P43490,Q15043 7 +Metanephric epithelium development 0.4356607754633779 0.6009044964160112 0.5479035982040177 1.0 0.7309981675450749 5 O95747,P11047 2 +Positive regulation of mapk cascade 0.3148047400976633 0.6005072863652238 0.548168206365319 1.0 0.7311493329296513 40 P05067,P14174,Q9UMX5 3 +Translesion synthesis 0.4712593212715 0.5962840139362982 0.5509855086145694 1.0 0.734031417471013 6 P28340,P55072 2 +Skin development 0.3176065955212024 0.5954301464379291 0.5515559793236104 1.0 0.7346374276154376 36 Q08J23,Q15392,O75844 3 +Positive regulation of deoxyribonuclease activity 0.3609479816869501 0.5949426701361362 0.5518817933958804 1.0 0.7348046242296326 3 Q05655 1 +Response to nutrient 0.3189785458519139 0.5943836619401413 0.5522555334948687 1.0 0.7348046242296326 32 P30536,P09601,P35573,P04818 4 +Regulation of dna replication 0.3102978325759638 0.5942047794434842 0.5523751564772159 1.0 0.7348046242296326 43 Q7Z6E9,Q96KQ7,Q9NRG0,Q7Z7L1,Q08211,Q9NRL2,P60953,Q9BRT9,Q9Y5K5,Q9NRF9,P35250,O75844,Q96QE3 13 +Protein homooligomerization 0.3114761741300835 0.5924509920093161 0.5535486289418723 1.0 0.735457434406219 42 P04183,P14174,Q99873,Q9BUB7,P34897,P34896,Q99797,Q99720,O00763,Q06481,Q9Y3Z3,O94788,Q12888,P38159,Q08379,P32929 16 +Positive regulation of cysteine type endopeptidase activity 0.3304820263468444 0.5877176813167813 0.5567218055457026 1.0 0.7391631272924639 28 Q9BZF9,Q96A26,O95831,P49327,P63167,P61586,P63244,P09429,Q99538,Q9NZJ7 10 +Nucleobase containing compound transport 0.26588250780777 0.5861281793100509 0.5577893809277656 1.0 0.7394394436925186 108 Q8TB61,Q92621,Q5SRE5,Q15388,P55735,Q5JVF3,Q08J23,P41440,Q09161,Q13769,Q96PU8,P51991,L0R6Q1,Q8NFH4,Q96MU7,Q9BTX1,Q92945,Q9H2D1,P84103 19 +Negative regulation of hydrolase activity 0.2843687810269105 0.585882515685853 0.5579544676179458 1.0 0.7394394436925186 58 Q5JVF3,Q99523,Q15392,O95429,Q06481,Q9UHD1,P05067,Q15043 8 +Immune response regulating signaling pathway 0.2891778480735257 0.5857110610653851 0.5580696997157035 1.0 0.7394394436925186 53 P04439,Q9Y6K9,P46379,P00813,Q5KU26,Q06481,P41440,Q9NUD5 8 +Phosphatidylglycerol acyl chain remodeling 0.322634017207155 0.5852554940936733 0.5583759357144413 1.0 0.7396910061277593 2 Q8NF37 1 +Positive regulation of cytokinesis 0.3864768782791057 0.5831754069133731 0.5597752250478458 1.0 0.7406845879986645 12 P61586 1 +Cell surface receptor signaling pathway involved in cell cell signaling 0.2806961645099345 0.581280657367102 0.5610513147373286 1.0 0.7418435940233952 72 P49815,Q9UQB8,P25398,Q9NPI1,P61586,P05067,Q00535,Q6DKJ4 8 +Nucleotide transport 0.386018251246723 0.5807382807864151 0.5614168574729763 1.0 0.7421018922257031 12 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Aminoglycan metabolic process 0.382907922843009 0.5799742152295219 0.5619320061420718 1.0 0.7425446634176732 13 Q7LGA3,P15586,P16278,P08236 4 +Embryonic organ morphogenesis 0.3474465640032405 0.5795280824813573 0.5622329035875235 1.0 0.7426099823958194 21 Q9BYW2,O75569,O95487,Q9UPW6,P63173,Q13308,P28482,O95747,P27361,Q8IZL8 10 +I kappab kinase nf kappab signaling 0.3055419873190275 0.5792288905434826 0.5624347393338629 1.0 0.7426099823958194 45 Q9Y6K9,Q8TB61,Q9H2U1,P61586,P09601,P19474,P32929 7 +Maintenance of cell polarity 0.3953642384105867 0.5792080770085939 0.5624487815062107 1.0 0.7426099823958194 4 O75083,Q8WUM4,O14745 3 +Cellular response to arsenic containing substance 0.4293583900499441 0.5764689509827249 0.5642982506818852 1.0 0.7441244152145358 9 P09601 1 +Regulation of cholesterol metabolic process 0.4545651194288023 0.5756405762370239 0.5648581487390247 1.0 0.7445537937339779 7 Q9UBM7,Q6P1A2 2 +Regulation of production of small rna involved in gene silencing by rna 0.4421123263655817 0.5749404622602551 0.5653315636473768 1.0 0.7448688678571158 8 O75844 1 +Regulation of nucleotide biosynthetic process 0.4543515343239617 0.5747452389447915 0.5654636070406744 1.0 0.7448884324042542 7 P09874,P00403 2 +Nucleoside bisphosphate biosynthetic process 0.3286585403665588 0.5741188555549279 0.5658873746337656 1.0 0.7451675302243536 28 Q8TB61,P50897,P09622,Q9UMR5,Q9NZ01 5 +Regulation of mrna 3 end processing 0.3621668403703776 0.5735601483131538 0.566265485847983 1.0 0.7451951854804375 18 Q9H2U1,Q09161,O43865,Q96MU7 4 +Negative regulation of proteasomal protein catabolic process 0.3520697778153244 0.5735410924302482 0.5662783842619836 1.0 0.7451951854804375 20 O43765,Q96KB5,P46379,Q99497,Q93009,Q9Y5K5,P62913,O94966,O15294,Q96HY6 10 +Regulation of reproductive process 0.3748410120740539 0.5733894605958723 0.5663810247911119 1.0 0.7451951854804375 15 P00813,O14965 2 +Negative regulation of proteasomal ubiquitin dependent protein catabolic process 0.3620708454252825 0.5729789010158772 0.566658979907412 1.0 0.7453817210868192 18 O43765,Q96KB5,P46379,Q93009,Q99497,Q9Y5K5 6 +10 formyltetrahydrofolate metabolic process 0.3565044687189661 0.5724830843914631 0.5669947425182813 1.0 0.7454874326470959 3 Q6UB35,Q9NRN7 2 +Tubulin deacetylation 0.3564761390184235 0.5723406566301931 0.5670912109579467 1.0 0.7454874326470959 3 P21333 1 +Triglyceride metabolic process 0.4143061046578542 0.5710000651180572 0.5679995987023272 1.0 0.7462185715899115 10 Q8WTV0,Q9HCL2 2 +Regulation of histone deacetylation 0.4140518534170667 0.5697864304502552 0.5688225601624914 1.0 0.7467686167121599 10 O43823,Q86XI2 2 +Intermediate filament organization 0.4645505074139071 0.5691543677114412 0.569251385212918 1.0 0.746963649273692 6 P08670 1 +Myeloid leukocyte activation 0.365974705228927 0.5691242005904644 0.5692718560543997 1.0 0.746963649273692 17 P14174,P09429,P09601,P53634,P05067 5 +Demethylation 0.3738930481819643 0.5680471402675579 0.5700029591387363 1.0 0.7477122116596094 15 P27695,Q16850,Q8NB78,Q7LBC6,Q93009,Q6P6C2,Q9H6W3 7 +Negative regulation of nik nf kappab signaling 0.3928388391707574 0.5675387220223592 0.5703482263559536 1.0 0.7478531565724756 4 Q9BZF9 1 +Cytoskeleton dependent intracellular transport 0.28264355771838 0.5665563024779051 0.5710156704491736 1.0 0.7482554111900493 59 P27695,Q9NZ32,Q15154,O43805,P07437,Q9Y4I1,P43034,Q8WXH0,O14617,A0AVF1,Q66K74,Q9UH99,Q96ED9,Q5SNT2,P05067,Q9Y2T2,Q00839 17 +Thioester biosynthetic process 0.3450677709832729 0.5639508025071928 0.5727876144504522 1.0 0.7498739603392532 21 Q13085,P35610,P50897,O00763,P09622,Q9UMR5,Q92947,Q53GQ0,Q9NZ01 9 +Autophagy of mitochondrion 0.3191765525167593 0.5619844331679599 0.5741266252543573 1.0 0.7511484170611158 31 P30536,P21796 2 +Odontogenesis 0.426028041394605 0.5613066637319826 0.5745884996292923 1.0 0.751457716799132 9 P61586 1 +Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.4623803193721389 0.5604509791040009 0.5751718674999207 1.0 0.7519112278546886 6 P09601,Q99497 2 +Mucopolysaccharide metabolic process 0.4384643615177935 0.55906049423385 0.5761204351806937 1.0 0.7526868419339134 8 P16278 1 +Positive regulation of histone h3 k4 methylation 0.3814916712000026 0.556821150269176 0.5776496317401587 1.0 0.753764001831076 12 Q92541,Q03164,P26358,P38398,P61964,O15294 6 +Maintenance of protein location in nucleus 0.4248200582858827 0.555833280534506 0.5783248320995362 1.0 0.75417165220038 9 Q9UH99,Q00535,Q99497,Q00839 4 +Microtubule organizing center localization 0.3782947093292295 0.5551089381103232 0.5788201495136751 1.0 0.7546627426274706 13 P43034,P49792,O14965,Q5T280,Q9UH99 5 +Positive regulation of protein containing complex assembly 0.2858397653349133 0.5521521916383562 0.5808440862465871 1.0 0.7566806747659987 53 Q9UQB8,P61586 2 +Purine containing compound metabolic process 0.2535704163640104 0.5497546367736621 0.5824876765524136 1.0 0.7586663262637584 135 P00846,P09874,P00403,Q8TB61,P00813,P61586,P50897,P09622,Q9UMR5,P55263,Q96DE0,O60725,P49773,P05067,Q13126,Q9UKG9 16 +Regulation of cell adhesion 0.2636205862014624 0.5483359211424281 0.5834612667621171 1.0 0.759778695255074 85 P04439,Q05655,Q9HCL2,P63167,P00813,P61586,O14617,Q99797,Q92766,P09429,P41440,O95429,P09493,Q9BTW9 14 +Positive regulation of response to external stimulus 0.2827965723939288 0.5478326985083276 0.5838067842020598 1.0 0.7599172476732114 54 Q8WXF1,Q99538,P21333,P14174,Q15233,P05067,Q15046,Q7Z434,P78527,Q99497,O60828,Q9NUD5,P23246,Q08211,P43243,P13010,P09429,P53634,O95747 19 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3791925180671595 0.5447716363311201 0.585910588585405 1.0 0.761875552587732 12 Q92896 1 +Sphingomyelin metabolic process 0.4581376154436249 0.5435433651602766 0.5867557417051932 1.0 0.762329116884334 6 O15269 1 +Inflammatory response to antigenic stimulus 0.4468227644338075 0.54342649638636 0.5868361866010774 1.0 0.762329116884334 7 P09429,Q99497,Q15046 3 +Regulation of organic acid transport 0.4219093384984881 0.5427039852288262 0.5873336298944607 1.0 0.7624780538417468 9 P14174 1 +Regulation of carbohydrate metabolic process 0.3164857589540063 0.5411273702090498 0.5884197941188685 1.0 0.7634203330107222 31 Q14108,P05067 2 +Establishment of golgi localization 0.3865002262759849 0.5385458670180051 0.590200248362255 1.0 0.7647360867446501 4 P60953 1 +Regulation of phospholipase a2 activity 0.3864218526697973 0.5381901389710613 0.5904457871957898 1.0 0.7647999640139475 4 Q9Y263,P50897 2 +Negative regulation of muscle hypertrophy 0.421000331235524 0.5379361035145442 0.5906211621950295 1.0 0.7648712524269778 5 P49840,O94826,P02545,P11413 4 +Biomineralization 0.420602704176893 0.5368379934104798 0.591379525136507 1.0 0.7656973440145933 9 O95747,O75844 2 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3378933683074411 0.5363701719832228 0.5917027419436169 1.0 0.7659583388540128 22 P09601,P14174,P46379 3 +One carbon metabolic process 0.3773986001718947 0.5354179486739972 0.592360881482672 1.0 0.766187578897815 12 P04818,P34896,O43865 3 +Plasma membrane organization 0.3310733670795569 0.5348217890716005 0.5927730945709602 1.0 0.766274391086552 24 Q9UQB8,Q05655,P31751,P35579,P41440,Q9Y5X1 6 +Bone remodeling 0.4559284930536667 0.5347978122294416 0.5927896760498075 1.0 0.766274391086552 6 O14773,P35222,Q9UBB6 3 +Bone resorption 0.4559284930536667 0.5347978122294416 0.5927896760498075 1.0 0.766274391086552 6 O14773,P35222,Q9UBB6 3 +Protein targeting to membrane 0.3108895583487966 0.5301304041326533 0.5960215201073362 1.0 0.7696693989846056 32 P50542,P46379,O43681,P31751,P43307,Q9UHD1,O60725,Q00535 8 +Regulation of embryonic development 0.3545647325008951 0.5279668774622367 0.5975223254854944 1.0 0.771294049712795 18 Q9H2U1,P46379,P43034,O95747,Q68CQ4 5 +Regulation of dendritic spine morphogenesis 0.3757338691426059 0.5267764572012776 0.5983488336959424 1.0 0.7718906407492205 12 Q9H2U1,Q9UQB8 2 +Regulation of lipid kinase activity 0.4182359227831516 0.5262846389153794 0.5986904542881435 1.0 0.7719122932046646 5 Q99570 1 +Regulation of catecholamine metabolic process 0.3837748344370759 0.526216603506447 0.5987377191470302 1.0 0.7719122932046646 4 P05091,Q99497,P00492 3 +Regulation of cellular amine metabolic process 0.3837748344370759 0.526216603506447 0.5987377191470302 1.0 0.7719122932046646 4 P05091,Q99497,P00492 3 +Positive regulation of oxidative stress induced cell death 0.3834628584171146 0.5248107129670254 0.599714783484667 1.0 0.7725551608894494 4 Q99497 1 +Folic acid containing compound metabolic process 0.3689910974130271 0.5219050465540919 0.6017364444281648 1.0 0.7743747399848988 14 Q9H2D1,P34896,P04818,P41440 4 +Regulation of hydrolase activity 0.2513991021515194 0.5186239388621043 0.6040230120209766 1.0 0.776845460219613 165 Q9BZF9,P63167,P43034,Q14108,P63244,Q99538,Q96F07,Q9UHD1,Q9NZJ7,Q92542,Q15043,P49815,O95831,O00170,Q9C0C9,Q5JVF3,O43847,P61586,Q15392,Q13526,P61289,P07602,P84095,P05067,Q05655,Q99523,P50897,Q06481,P31751,O95429,Q9P258,Q9Y4G8,Q9Y5X1,Q96A26,P49327,Q01968,Q13557,P09429,P30044,Q9Y5K5 40 +Negative regulation of cellular protein catabolic process 0.3207316722873115 0.5158016003600173 0.6059929847058037 1.0 0.7781194769272906 28 O43765,Q96JB5,Q96KB5,P46379,P46777,Q99497,Q93009,Q9Y5K5,Q96HY6 9 +Dna dealkylation 0.4507768467192411 0.514563998126915 0.6068577283049286 1.0 0.7786272311249272 6 P27695,Q8N3C0 2 +Phagocytosis 0.3079498842691062 0.5125890210192773 0.6082388347080296 1.0 0.7799003496881655 35 Q05655,Q8WTV0,Q5KU26,P63244,Q06481,P09429,P84095,P35579 8 +Response to arsenic containing substance 0.3670380072907964 0.5114072459327204 0.6090659221785011 1.0 0.7804343497813975 14 Q9H2U1,P09601,P36551 3 +Adaptive immune response 0.3052414066331954 0.5112535672154855 0.6091735138697341 1.0 0.7804343497813975 39 O96028,P04439,P10321,P00813,Q9UQ84,Q9NZ08,P36915,P53634,Q96QE3 9 +Cardiac cell development 0.3726792534211421 0.5110196697868362 0.6093372835421906 1.0 0.7804343497813975 12 O75844 1 +Germ cell proliferation 0.3087359364659245 0.5096879897509677 0.6102700684964968 1.0 0.780929445412469 2 Q13162 1 +Activation of immune response 0.2959030316122767 0.5074568776533018 0.6118342859873418 1.0 0.7823010906730125 46 Q8WXF1,Q07666,Q13144,Q9Y6K9,Q15233,P00813,P04439,Q05655,Q7Z434,P78527,Q06481,O60828,Q9NR50,Q9NUD5,P23246,P46379,P49770,P43243,P13010,P09429 20 +2fe 2s cluster assembly 0.3791390728476741 0.5054444522997241 0.6132467038359899 1.0 0.7837916850153934 4 O76003,Q86SX6,Q9H3K6 3 +Positive regulation of binding 0.2784340209614749 0.5040581135729155 0.6142205401171852 1.0 0.7845630532525782 54 P09874,P35611,Q13526,P62826,Q08211,P09429,Q99497,P19474,P41440,Q96D46,Q09161,O75503,P05067,Q00535,Q9Y4G8 15 +Negative regulation of ubiquitin dependent protein catabolic process 0.3296296610846581 0.5023968179062427 0.6153884169650263 1.0 0.7852657655550506 23 O43765,Q96KB5,P46379,P46777,Q99497,Q93009,Q9Y5K5 7 +Negative regulation of peptidyl tyrosine phosphorylation 0.4125748240694046 0.5011942426553526 0.6162344258009367 1.0 0.7860297030685839 9 Q05655,Q86XI2,O95684,P63244,Q99816 5 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.3706714201573401 0.5007348009179641 0.6165577766820389 1.0 0.7862687654991972 12 Q96A26,O95831,P63167,P63244,Q9NZJ7 5 +Anatomical structure formation involved in morphogenesis 0.250970296076754 0.5005764259647469 0.6166692567673848 1.0 0.7862687654991972 139 P25440,P63167,P43034,Q9NR77,P42785,P09601,Q6RFH5,P35579,Q9H9Y6,Q00535,Q92541,P49815,P07737,Q9Y3B4,P00813,P61586,P41440,P09493,P78527,Q9NZ08,Q96N66,Q9H488,Q969H8,O95487,Q13045,P52789,O95747,Q96T37 28 +Negative regulation of transmembrane transport 0.3404127587435835 0.5003628312167602 0.6168196200484819 1.0 0.7863027487019957 20 Q06481,Q13557,P31751,P21796 4 +Positive regulation of chromosome segregation 0.4243796787738952 0.4989210244715814 0.6178350220204738 1.0 0.7872762063852744 8 Q8IY18,Q00839 2 +Tor signaling 0.3450410721570282 0.4987509521138866 0.617954844816887 1.0 0.7872762063852744 19 P49815,P55735,O75844 3 +Regulation of cell cycle g1 s phase transition 0.3064161891067143 0.4977531200805294 0.6186580621741569 1.0 0.7880141569496876 34 P27695,Q9NPI1,P78527,P61289,Q06481,Q96DY7 6 +Calcium ion import 0.3983097940599299 0.4960208727483964 0.6198796845737156 1.0 0.7889232802230645 10 P21796,O75844 2 +Regulation of dendrite extension 0.3409467063886082 0.4958610984107 0.6199924142092836 1.0 0.7889232802230645 3 O60271,Q9Y263 2 +Muscle cell cellular homeostasis 0.4106589760553318 0.4947451972671338 0.6207799931139273 1.0 0.7897239334515024 5 P13473 1 +Regulation of chromatin assembly 0.3638492388785145 0.494392289185433 0.6210291585689476 1.0 0.7897681736423031 14 Q13263,O60341,P26358,P24941,Q8NEY8,Q15047,Q9UK61,Q9Y6X9 8 +Endoplasmic reticulum tubular network organization 0.4228009725307416 0.4923048445874407 0.6225038558613916 1.0 0.7905363652057952 8 O95197,Q9H2M9,P57088 3 +Regulation of endodeoxyribonuclease activity 0.3756415914218335 0.4899460187348794 0.6241720978187071 1.0 0.7921800826149565 4 P09429 1 +Ceramide biosynthetic process 0.433255706615736 0.488271150978578 0.6253577928954068 1.0 0.7931492261796752 7 Q05655,O15269 2 +Regulation of cell morphogenesis involved in differentiation 0.324014583371132 0.4868688742267799 0.6263512578356951 1.0 0.7936779495222643 24 Q9UQB8,Q9H2U1,P43034,P78527,Q92766,Q9P258 6 +Neural crest cell migration 0.3382985766302494 0.4831631856914974 0.6289798726374398 1.0 0.7958980829153031 3 P60953,P08133 2 +Long chain fatty acyl coa metabolic process 0.420338156955913 0.4820369558059962 0.6297796937886793 1.0 0.7961191780075717 8 Q8WVX9,Q53GQ0,Q9NZ01 3 +Gene silencing by rna 0.2874916782887738 0.4810883910279848 0.6304536784794084 1.0 0.7967945478990693 49 Q9UGR2,Q9Y2W6,Q8IWR0,O75569,Q5KU26,P62826,Q99598,P42694,P17844,Q5T280,O75844 11 +Rna stabilization 0.319409223547568 0.4793428962804933 0.631694710186919 1.0 0.7980623291488883 25 O60506,P98175,Q9H2U1,Q08211,Q14103,Q08J23,P16989,Q00839 8 +Roof of mouth development 0.440910979949444 0.4764798704062383 0.6337325448453808 1.0 0.7995907167705768 6 Q9UPW6 1 +Response to indole 3 methanol 0.3725165562913736 0.4762294920068374 0.6339108907814563 1.0 0.7995907167705768 4 P14923,P38398,P35222 3 +Cellular response to indole 3 methanol 0.3725165562913736 0.4762294920068374 0.6339108907814563 1.0 0.7995907167705768 4 P14923,P38398,P35222 3 +Regulation of fibroblast migration 0.4183889546355329 0.4739575919624824 0.6355301488295777 1.0 0.800679806929791 8 Q06481,O95429 2 +Stress activated protein kinase signaling cascade 0.303286198447119 0.4712542268556974 0.6374591986697142 1.0 0.80274597856654 32 P49327,Q96KB5,P43034,P61586,P09429,Q99873,P05067,O75844 8 +Regulation of mitotic nuclear division 0.3018990038802785 0.4680656588279577 0.6397376364137104 1.0 0.8048052336349844 36 Q69YH5,Q5JVF3,P30260,Q13526,P46013,P50748,Q96DY7,O14965 8 +Histone phosphorylation 0.3397037964987511 0.4669739557840718 0.6405185116628991 1.0 0.8055274357201002 19 O43823,O14965,Q9UIG0,Q00535,O75844 5 +Positive regulation of focal adhesion assembly 0.4034448492878563 0.4652897929175392 0.6417239433121493 1.0 0.8064393161936982 5 Q13464,P63000,Q9Y2S7,Q96AC1 4 +Positive regulation of cell matrix adhesion 0.403980099502478 0.4638424936083328 0.6427605960513143 1.0 0.8075482009294631 9 Q13464,P63000,Q96AC1,Q00534,P14923,Q13630,Q9Y2S7,P46939 8 +Regulation of leukocyte mediated immunity 0.3128358819564698 0.4618614001003683 0.6441807162649393 1.0 0.8082294365366851 27 O96028,P04439,Q9H2U1,P09601,Q96QE3 5 +Response to gamma radiation 0.3570718111021625 0.4587696354612247 0.6463996020117624 1.0 0.8103581598395979 14 P09874,O75844 2 +Oxidative phosphorylation 0.2719265907067959 0.4573577027976899 0.6474139609940592 1.0 0.8110855188281285 58 P00403,P14406,O14949,Q9BSK2,O95298,O75251,P61586,P09622,P51970,Q9UDW1,Q9Y6M9,P20674,P34897,P22695,P31930,Q99497,P08574,P00846,P56134 19 +Negative regulation of proteolysis involved in cellular protein catabolic process 0.3161629982466491 0.4572515728392003 0.647490233249516 1.0 0.8110855188281285 25 O43765,Q96KB5,P46379,P46777,Q99497,Q93009,Q9Y5K5,Q96HY6 8 +Platelet morphogenesis 0.4357223567030207 0.4568253421098834 0.6477965891143831 1.0 0.8113093833322205 6 Q06124,P35579,P78527 3 +Circulatory system development 0.2485349194258297 0.4564834189210676 0.6480423915607143 1.0 0.8114573366351261 143 O96028,P26358,Q9H2U1,P63167,P42785,P09601,P49815,P61586,P09493,Q00839,P32929,Q53GG5,Q9BZH6,P42892,P78527,Q96PU8,Q9NZ08,Q9Y4G8,O75844,Q969H8,P52789,O95747,Q6DKJ4 23 +Sphingoid metabolic process 0.4009025632052038 0.4550510535869417 0.6490725100671364 1.0 0.8119913872474857 5 O15269 1 +Ovulation cycle process 0.3316782522343582 0.4519027943423607 0.6513390113067672 1.0 0.8139206743435246 3 O95470,O75592 2 +Female gamete generation 0.332403886350627 0.4515706265349126 0.6515783347369029 1.0 0.8139606713026247 20 Q9Y2W6,Q96MU7,O14965,Q6IBW4,O60879 5 +Positive regulation of myeloid leukocyte mediated immunity 0.4341945922447863 0.4510899693082763 0.6519247067951963 1.0 0.8140733666778521 6 Q9H2U1,Q92499 2 +Negative regulation of protein binding 0.3242547060033474 0.4484378152014242 0.6538372556176664 1.0 0.8158204940529815 22 Q05655,Q13526,P63244,O14965,P10586,Q08379 6 +Protein export from nucleus 0.3179566503719979 0.4466081214486054 0.6551580306854914 1.0 0.8173080359248249 24 Q9HAV4,O43865,Q9C0E2,P62826,Q9UIA9,P61970,Q99497,Q9UHD1,Q06124,Q00535 10 +Antigen processing and presentation 0.3238599270307353 0.4459530393611484 0.655631168168002 1.0 0.8175773405681422 22 P04439,P10321,Q9UIQ6,Q9NZ08,Q99538 5 +Protein localization to endoplasmic reticulum 0.2997753341833872 0.4449823505325971 0.6563325088997929 1.0 0.8180965034837067 33 P46379,P24390 2 +Endosome to lysosome transport 0.3511663626929238 0.4439996035097236 0.6570428705704661 1.0 0.8186219814110592 15 Q99523,O14617,P55072,Q96L92,Q9H267,Q96ED9 6 +Cellular response to cadmium ion 0.4322709376159803 0.4439027977361901 0.6571128617305262 1.0 0.8186219814110592 6 P09601 1 +Regulation of polysaccharide metabolic process 0.4320549803040734 0.4430983577888505 0.6576945929751965 1.0 0.819025633415037 6 P49840,P62140,P62136,P31751 4 +Negative regulation of mapk cascade 0.3105307601607902 0.4429176047188684 0.6578253332154878 1.0 0.8190279760857277 28 Q05655,Q96JB5,Q96KB5,P43034,P47897,Q13526,Q8IV63,P31689,P78318,O75832,P04062 11 +Integrin mediated signaling pathway 0.3566742979815312 0.4425999576407204 0.6580551154201746 1.0 0.8191536062692185 13 P21333,Q9P258,P35579,P60953 4 +Leukocyte proliferation 0.2981159772091891 0.4423533882865075 0.6582335030988433 1.0 0.8192152233593594 37 P04439,Q05655,P14174,P17812,Q9HCL2,P00813,P09429,Q92542,Q96QE3 9 +Regulation of mitophagy 0.4215413055762433 0.4421333293164434 0.6583927275115355 1.0 0.8192529710382381 7 P21796 1 +Endoplasmic reticulum organization 0.2966606496743932 0.4414270301320233 0.6589038773068288 1.0 0.819538374466801 39 O14976,Q6P1A2,P49257,P50542,P46379,P57088,O43681 7 +T cell mediated immunity 0.3860926640693969 0.4408638708289778 0.6593115507724003 1.0 0.819538374466801 10 P36915,P04439,P53634 3 +Brown fat cell differentiation 0.4312609347010041 0.4401447809913796 0.6598322501669023 1.0 0.819538374466801 6 Q00839 1 +Rescue of stalled ribosome 0.4312535882968399 0.4401174861061654 0.659852017886221 1.0 0.819538374466801 6 Q9H1I8,P63244 2 +Regulation of nucleotide metabolic process 0.3504225632194869 0.4400859105243986 0.6598748861019696 1.0 0.819538374466801 15 P09874,P05067 2 +Regulation of phosphatidylcholine biosynthetic process 0.3290301224759915 0.4396015601081061 0.6602257105776428 1.0 0.819538374466801 3 O95573,Q8NF37 2 +Inositol phosphate metabolic process 0.3639970659137336 0.4395013510599633 0.6602983032794978 1.0 0.819538374466801 4 Q10713 1 +Regulation of double strand break repair via nonhomologous end joining 0.3855096863748967 0.4382826665906715 0.6611813894213767 1.0 0.819993933885321 10 Q9BRJ7,P78527 2 +Sphingolipid biosynthetic process 0.3497177058978555 0.4363865898974965 0.6625562668587368 1.0 0.8210582242452975 15 Q05655,Q99805,Q06136,O15269 4 +Limbic system development 0.3386471484718575 0.4357380914933487 0.663026765463504 1.0 0.8211370694681254 18 P27695,O75569,O14949,P62826,A0AVT1,Q00535 6 +Mononuclear cell migration 0.3221101325743394 0.4349840170308249 0.6635740288098688 1.0 0.8211370694681254 22 P09429,P61586,P05067,O95747 4 +Immune effector process 0.2689076144345063 0.4347011597986207 0.6637793564395205 1.0 0.8211370694681254 68 O96028,P04439,P14174,P68371,Q9H2U1,P00813,Q9UQ84,Q06481,P09601,P36915,P53634,P05067,Q96QE3 13 +Positive regulation of cation channel activity 0.4297914946049609 0.434696679357909 0.6637826090193877 1.0 0.8211370694681254 6 P27695 1 +Clathrin dependent endocytosis 0.3418015454385835 0.4312773784141628 0.6662666967847308 1.0 0.8235688690711298 17 Q5VW38 1 +Dendritic spine morphogenesis 0.3484541790411392 0.4297785103539916 0.6673567664554958 1.0 0.8244352978797145 15 Q9H2U1,Q9UQB8 2 +Inorganic ion import across plasma membrane 0.418257723269925 0.429471672019835 0.6675800049751504 1.0 0.8245393893982723 7 Q92581,Q15043,P05023 3 +Embryonic axis specification 0.4281763127335604 0.4287350579986793 0.6681160444571335 1.0 0.8248923035294368 6 Q9Y2W6 1 +Protein homotetramerization 0.3234612914105836 0.4273757421526161 0.6691056730059399 1.0 0.8257933315778163 21 P04183,P34897,P34896,Q99797,O00763,Q06481,Q9Y3Z3,O94788,Q08379,P32929 10 +Establishment of rna localization 0.2571866239159829 0.4268738704110053 0.6694711982817831 1.0 0.8259237065758955 95 P55735,Q5JVF3,Q13769,Q92621,Q8NFH4,P62826,Q96MU7,Q96PU8,Q08211,Q08J23,P51991,Q5SRE5,Q9BTX1,P41440,Q15388,Q92945,P84103,Q09161 18 +Rrna 5 end processing 0.3603672560604432 0.4241652485708149 0.6714453028428518 1.0 0.8277165137449894 4 O75691 1 +Positive regulation of cytokine production 0.2674279392001686 0.4215113728950849 0.673381708263753 1.0 0.8291387326083716 55 P04439,P14174,Q9H2U1,P09601,O15111,P41440,O60828,Q9NUD5,P05067 9 +Supramolecular fiber organization 0.2450142133369078 0.4185391121434205 0.6755529963967679 1.0 0.8312705732282674 168 Q9UQB8,P63167,P43034,Q8WUW1,O60879,Q6WCQ1,Q96F07,Q9UHD1,P07737,P21333,Q15154,O15143,P08670,P07197,Q9UEY8,Q9Y4I1,P61586,Q13526,P06753,Q7L576,P84095,Q66K74,Q96ED9,P05067,P09493,Q08379,Q9BTW9,Q05655,O15020,O75718,O95425,Q99497,Q9UHV9,O95429,Q9Y5X1,Q96CW5,Q13045,P67936 38 +Pyrimidine containing compound metabolic process 0.313248727690126 0.4159460470932355 0.6774494835798448 1.0 0.8330123532189541 24 P04183,P17812,P32321,P34896,P04818,P27708,Q9H773,P84090 8 +Rhythmic process 0.2692623634387381 0.4149083396191784 0.6782090045566223 1.0 0.8336257529938637 54 Q8WXF1,Q03164,Q9BWF3,Q9H2P0,P63244,Q14103,P06493,Q00535,O15294,Q15233,P04818,Q9BQG2,P17844,Q00839,O95470,Q7Z6Z7,P12004,P78527,P43490,P62140,P23246,Q08211,Q93009,Q9NRV9 24 +Synaptonemal complex organization 0.424351760831002 0.4147329872660094 0.6783373811334585 1.0 0.8336257529938637 6 P46379 1 +Positive regulation of cell morphogenesis involved in differentiation 0.3213291948296201 0.4144483102577828 0.6785458148688099 1.0 0.8337207035194579 21 Q9UQB8,Q9H2U1,P43034,Q92766,P78527 5 +Single fertilization 0.315989071992579 0.4141834551948777 0.6787397575317502 1.0 0.8337947659732351 23 P45880,Q96CW5,P55769,P35579,Q9GZP4 5 +Regulation of myelination 0.3918278765137756 0.4126117065838802 0.6798911229365707 1.0 0.8348894855843979 9 Q7L576 1 +Endothelium development 0.3156676645985801 0.4121596482322864 0.680222411217194 1.0 0.8349094734437195 23 P61586 1 +Vacuole organization 0.2878054188304191 0.4120578302869235 0.6802970364140517 1.0 0.8349094734437195 44 Q8N511,Q9HC07,Q14108,Q96NT0,P50897,O75503,Q96ED9 7 +Regulation of rho protein signal transduction 0.3660175328171603 0.4095674402356531 0.682123285652737 1.0 0.8363378864986104 11 P41440 1 +Negative regulation of intracellular signal transduction 0.2554773829048192 0.4086261873388229 0.6828140096865791 1.0 0.836940552583695 98 P49815,Q9BZF9,P14174,P63167,Q13769,P45880,Q96KB5,P61586,Q13526,Q8IWV8,O75832,Q9UHD1,Q10713,P16989,Q96QE3 15 +Trna transcription 0.4226454024639048 0.4085387619069091 0.6828781789960734 1.0 0.836940552583695 6 P62875,Q8WUA4 2 +Cilium organization 0.2732074644106474 0.408041395086516 0.6832432843919496 1.0 0.8372265887016063 52 P27695,P21333,A6NIH7,Q15154,O43805,Q9BZH6,P63167,Q01968,Q9Y6A4,Q14141,A0AVF1,Q9NT62,Q9NVG8 13 +Regulation of multicellular organism growth 0.3439930009741833 0.4066929425581041 0.6842335245699576 1.0 0.8382783890066788 15 Q9HCL2,O75844,P05067,P50542 4 +Regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.4014853068860475 0.4057711247142425 0.6849107769687663 1.0 0.8386872897238141 8 P14174 1 +Regulation of jnk cascade 0.3513241400687816 0.4048867175363567 0.6855607822046266 1.0 0.8390498346211417 12 P43034,P60953,P05067,P09429 4 +Nuclear pore organization 0.3488933842851682 0.403988941794429 0.6862208509219481 1.0 0.8392246383522557 13 Q92621,Q9BTX1 2 +Muscle cell differentiation 0.2668481273492198 0.4038456106893262 0.6863262539576818 1.0 0.8392246383522557 60 Q8IV08,P26358,Q99523,O75844,P41440,P09493,Q00839,P32929 8 +Regulation of anatomical structure size 0.2552403934303778 0.4020615353607744 0.68763873989769 1.0 0.8405061213057149 92 Q9UQB8,P07737,Q9UEY8,Q05655,P43034,Q9HB40,P61586,Q8WUW1,P42892,O95425,Q13045,Q7L576,Q96F07,O95429,Q00535,Q9Y5X1 16 +Positive regulation of peptidase activity 0.2906793586844505 0.4004181294616037 0.6888485733501075 1.0 0.8417934906302623 40 Q9BZF9,Q96A26,O95831,P49327,P63167,P61586,P63244,P61289,P05067,P09429,Q99538,Q9NZJ7,Q92542 13 +Regulation of transcription by rna polymerase iii 0.3638484479144576 0.3997316577839427 0.6893541722357639 1.0 0.8417934906302623 11 Q9H2U1,P30044 2 +Negative regulation of tor signaling 0.3867200922042799 0.3993950565612597 0.68960213587499 1.0 0.8417984103348235 5 P49815 1 +Positive regulation of defense response 0.2933260261631567 0.3991768601407263 0.6897628921946861 1.0 0.8418074006892137 35 Q8WXF1,Q15046,P23246,Q15233,Q7Z434,Q08211,P78527,P43243,P09429,P53634,Q99497,O60828,Q9NUD5,P05067 14 +Carbohydrate derivative biosynthetic process 0.2450882837638966 0.3988275209562076 0.6900202971624345 1.0 0.8419598788182825 155 P00403,Q8TB61,Q9UHD1,Q92542,Q13126,P00813,Q7LGA3,Q2TAA5,Q10472,P04818,Q8NBX0,P09622,P55263,O60502,Q86YN1,O15118,Q9BV10,P09874,Q99805,P32321,P50897,P00846,Q9HC07,Q9UMR5 24 +Synaptic vesicle transport 0.3995420988112544 0.398163227358026 0.690509870155259 1.0 0.8423867068967589 8 Q00535,O14617 2 +Response to calcium ion 0.3133968847617937 0.3979389264497657 0.6906752053351197 1.0 0.8423867068967589 23 Q13557,O43865,Q14103,Q99538,Q92542 5 +Sarcoplasmic reticulum calcium ion transport 0.4096189558694995 0.3967691136761557 0.6915377289112192 1.0 0.8430022640889354 7 O75844 1 +Telomere organization 0.266148438581705 0.3960961056120285 0.6920341311366127 1.0 0.8434456256000595 61 P27695,P09874,Q9H2U1,Q9UQ84,P49750,Q14103,P78527,P41440,Q8IY18,Q15185,Q00839 11 +Heterochromatin organization 0.2929028939472562 0.393651303864279 0.6938384981599142 1.0 0.8450422750213709 32 Q9NRF9,Q9Y6X9,Q8IWV8,P26358 4 +Regulation of pattern recognition receptor signaling pathway 0.3225747550973231 0.3936005637166533 0.6938759649679884 1.0 0.8450422750213709 20 Q06481,Q9NUD5,P41440 3 +Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna 0.3466427832464633 0.3930308125225644 0.6942967237834354 1.0 0.8453927157792176 13 Q5SY16,O00541,Q14137 3 +Cerebral cortex development 0.3095507226484467 0.3922749887424131 0.6948550418049184 1.0 0.8457997005473791 24 P61586,Q00535,P50542 3 +Cardiolipin metabolic process 0.4179805567235675 0.3917764596028794 0.695223389971785 1.0 0.8457997005473791 6 P40939 1 +Negative regulation of cell death 0.232123384928475 0.3916777609042205 0.6952963240025261 1.0 0.8457997005473791 203 Q9UMX5,P26358,Q9HCL2,P09601,O14965,Q00535,P21796,Q9Y6K9,P14174,Q5JVF3,P00813,P61586,Q15392,P61289,O75832,O15118,P32929,P78527,P50897,P31751,O95429,Q96QE3,Q86XL3,Q969H8,P45880,P46379,P30044,P16989 28 +Leucine catabolic process 0.3524617898791601 0.3914547627123609 0.6954611203147729 1.0 0.8458382856335049 4 Q96RQ3 1 +V d j recombination 0.4176165129867246 0.3904790919313357 0.6961823129356954 1.0 0.8460010596769898 6 P78527 1 +Regulation of gene expression epigenetic 0.2837614947244738 0.389808261604387 0.6966783342143139 1.0 0.8460010596769898 45 P26358,Q8IWV8,Q96MU7,Q9NRF9,Q9UFW8,Q00839,Q9Y6X9 7 +Positive regulation of canonical wnt signaling pathway 0.340598433715965 0.3893929617071219 0.6969854777638047 1.0 0.8460010596769898 15 P25398,Q13526,P55072 3 +Negative regulation of telomere maintenance via telomere lengthening 0.40755424202013 0.3890891304227567 0.6972102138828806 1.0 0.8460010596769898 7 P09874 1 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.3859828426843651 0.3886914442425107 0.6975044121789442 1.0 0.8460010596769898 9 Q08211,Q00839,Q14103 3 +Crd mediated mrna stabilization 0.3859828426843651 0.3886914442425107 0.6975044121789442 1.0 0.8460010596769898 9 Q08211,Q00839,Q14103 3 +Dopamine metabolic process 0.3839019542895067 0.3886495145065221 0.6975354334006432 1.0 0.8460010596769898 5 P05091,Q99497,P21964,P00492 4 +Catechol containing compound metabolic process 0.3839019542895067 0.3886495145065221 0.6975354334006432 1.0 0.8460010596769898 5 P05091,Q99497,P21964,P00492 4 +Regulation of intracellular steroid hormone receptor signaling pathway 0.3118747739715964 0.3884844464068158 0.697657562003521 1.0 0.8460010596769898 23 P61586,P09874,Q86X55 3 +Microtubule anchoring at centrosome 0.3176615671589791 0.3882139611580792 0.6978577023106447 1.0 0.8460010596769898 3 Q15154 1 +Microtubule anchoring at microtubule organizing center 0.3176615671589791 0.3882139611580792 0.6978577023106447 1.0 0.8460010596769898 3 Q15154 1 +Positive regulation of telomere maintenance via telomere lengthening 0.3336013189504778 0.3870251306331712 0.6987376033904527 1.0 0.8466851581887788 17 P22626,Q9H2U1,P17987,P50991,Q99832,P13010,P49368,P28482,P27361 9 +Mesonephric tubule morphogenesis 0.3509935692512388 0.3854883152993261 0.6998756618966551 1.0 0.8474775589664963 4 Q9BRK4,O95747 2 +Ribonucleoside monophosphate biosynthetic process 0.3253356503757108 0.3843867421740845 0.7006918253984789 1.0 0.8481426856280198 19 P00813 1 +Smoothened signaling pathway 0.3292870631510836 0.3838918839130503 0.7010585820352255 1.0 0.8484250471088906 18 O43805,Q9BZH6,P63244,A0AVF1,Q9Y5K5 5 +Cell morphogenesis involved in differentiation 0.2475930629712987 0.3821762029262718 0.7023306718634967 1.0 0.8498027318416876 116 Q9P258,Q9UQB8,Q9H2U1,P61586,P42892,P78527,Q92766,Q06481,Q7L576,P84095,P35579,P41440,Q66K74,O60828,P05067,Q00535,Q9Y4G8,Q9BTW9 18 +Metanephric tubule development 0.3498839404012677 0.3810024036416968 0.70320146497496 1.0 0.8503707213433879 4 O95747 1 +Prostanoid biosynthetic process 0.4147048158861495 0.3801597410876518 0.7038268417022648 1.0 0.8508726813993516 6 P14174 1 +Negative regulation of phosphatase activity 0.4146214121162408 0.3798656628056991 0.7040451372382801 1.0 0.8508726813993516 6 O95429 1 +Sno s rna metabolic process 0.3438906231167683 0.3797648432391878 0.7041199816376085 1.0 0.8508726813993516 13 Q96DE0 1 +Actin filament organization 0.251933841125221 0.3775547543385957 0.7057613817302264 1.0 0.851717877456527 104 Q9UQB8,P63167,Q8WUW1,O60879,Q6WCQ1,Q96F07,P07737,P21333,Q9UEY8,Q9Y4I1,P61586,P06753,Q7L576,P84095,P09493,Q05655,O95425,O95429,Q9Y5X1,Q13045,P67936 21 +Abscission 0.2822634017207235 0.3757711027389706 0.7070870726549245 1.0 0.8527979950274575 2 Q8N0X7 1 +Positive regulation of translation 0.2634626749026554 0.3744540121425662 0.7080665649383011 1.0 0.8529196570553094 58 Q567V2,P08670,Q7Z478,Q9H2U1,P61586,P78527,Q14103,P16989,Q00839 9 +Double strand break repair via nonhomologous end joining 0.3035435487493148 0.3740116232997795 0.7083956685958115 1.0 0.8529196570553094 25 Q9BRJ7,O96028,P78527,P09884,Q8IY18 5 +Protein catabolic process 0.2255595292509944 0.372840769118335 0.7092669577203008 1.0 0.8536452912838917 251 P60900,Q9NUJ1,P46777,Q96NT0,P63244,Q9H1I8,Q99538,O14965,Q9UHG3,Q9UMY4,Q9Y5A7,Q86UV5,Q8NEZ5,P21333,Q92890,Q9C0D3,O43765,Q96JB5,Q96KB5,O43847,Q9Y4X5,Q13526,Q5T4S7,P61289,P49721,O75832,P25788,P28074,O60502,O94966,P20618,P63208,Q8N511,Q16850,Q8WUX9,Q92990,Q8N3C0,P50897,Q9Y263,Q15366,P10619,A0AVT1,Q99497,P13473,Q68CQ4,Q9UBV2,Q9GZP4,O75844,Q7Z6E9,Q9Y5X1,P30260,P46379,Q9H7D7,Q9UIQ6,O00462,Q8IWV8,P55072,Q15369,P53634,Q93009,O75503,Q9Y5K5,Q86Y37,Q96HY6 64 +Protein exit from endoplasmic reticulum 0.3119090250110307 0.372565649070829 0.7094717430672288 1.0 0.8536580943280648 22 P55735,O15260 2 +Purine nucleoside monophosphate metabolic process 0.311695906399599 0.3712910915645859 0.7104207324171607 1.0 0.854386788125539 22 P00813 1 +Regulation of calcium ion transmembrane transport 0.3305743139734411 0.3710627887399194 0.7105907659060473 1.0 0.8544296080398859 17 P27695,Q00535,P21796 3 +Pyrimidine nucleoside triphosphate metabolic process 0.3440686737087591 0.3706439958592678 0.7109027084451218 1.0 0.8546430139733675 12 Q9H773,P04818,P17812,P27708 4 +Negative regulation of neuron apoptotic process 0.299380837075035 0.3698971904276976 0.711459094922511 1.0 0.8551501526716112 27 Q9H2P0,Q15233,O75312,P61586,Q9UNH7,P50897,P09601,Q99538,Q99497,Q01105 10 +Reproduction 0.2277757420181417 0.3678337481189291 0.71299720315178 1.0 0.8563511381770055 209 P11717,Q9H2U1,P42695,Q14141,O14965,P35579,Q9NZJ7,Q96KQ7,Q9BQE5,P00813,Q15392,P62826,P55769,P07602,P09622,Q08J23,P41440,P05067,P78527,Q99598,Q96PU8,Q9UH99,Q9GZP4,Q9Y2W6,P45880,P46379,Q9UIQ6,Q9UQ84,Q8IWV8,Q96MU7,Q15067,Q96CW5,A0AVF1,O95747,Q9BTX1,P16989 36 +Negative regulation of gene expression epigenetic 0.2928101039548199 0.3660871323754684 0.7143000589327735 1.0 0.8575918350163786 31 Q9NRF9,Q9Y6X9,Q8IWV8,P26358 4 +Response to dopamine 0.3407291545375182 0.3647136140102871 0.7153251951108497 1.0 0.8578503660612379 13 P21333,P62873,P49840,P28482,Q92542 5 +Embryo development 0.2394397391634152 0.3637933567735867 0.7160123237703702 1.0 0.858193883904665 179 Q03164,P25440,P26358,Q9H2U1,P43034,P63167,Q8WUW1,P63244,Q6RFH5,P35579,Q9H9Y6,Q92541,P49815,P07737,Q9Y3B4,Q9UPW6,P00813,P62753,O43772,P09622,Q08J23,O75569,Q13769,P42892,P78527,Q68CQ4,Q9UK61,Q9H488,Q9Y2W6,Q01968,O95487,Q86XI2,P46379,Q96MU7,Q8IWS0,O95747,Q6DKJ4,Q99873,Q9H0G5,P16989 40 +Positive regulation of cell cycle g2 m phase transition 0.3403000604409799 0.3626865821340525 0.7168390241237137 1.0 0.8587869036491229 13 P11802,P06493,O75351,P05067,Q9P258,Q96QE3 6 +Regulation of cation transmembrane transport 0.285802910493169 0.3624959206975522 0.7169814713671459 1.0 0.8587869036491229 40 P27695,Q13557,Q9UHD1,P05067,Q00535,P21796 6 +Regulation of synaptic vesicle recycling 0.3997889497358978 0.3607001811189773 0.7183235893010806 1.0 0.8590395467515134 7 Q7L576,Q00535 2 +Nadh dehydrogenase complex assembly 0.3045161375958392 0.3606727278267171 0.7183441143776421 1.0 0.8590395467515134 24 Q9Y6M9,Q86Y39,O95298,O75251,P51970,Q9H061,Q96CU9 7 +Notch signaling pathway 0.3371450909140103 0.3588658005987164 0.7196954849357888 1.0 0.8600083666576187 14 Q92542,Q9H488,P05067,Q96T37 4 +Negative regulation of epithelial cell migration 0.3783474166407597 0.3582082603339198 0.7201874660017631 1.0 0.8604344988547381 9 P61586 1 +Positive regulation of calcium ion transmembrane transporter activity 0.3984924802250718 0.3560389696305711 0.7218113813053268 1.0 0.8618886228774484 7 P27695 1 +Positive regulation of hydrolase activity 0.2512778784389726 0.3556853955667032 0.7220761833844187 1.0 0.8620428665648695 90 Q9BZF9,P63167,P63244,Q99538,Q9NZJ7,Q92542,P49815,O95831,P61586,Q13526,P61289,P07602,P84095,P05067,Q05655,P31751,Q9P258,Q9Y4G8,Q9Y5X1,Q96A26,P49327,P09429 22 +Peptidyl tyrosine dephosphorylation 0.3774749034037885 0.3547823848963307 0.7227526258719155 1.0 0.8625264157044489 9 P10586,Q9Y217 2 +Astrocyte differentiation 0.3405115079036749 0.3542334867890765 0.7231639096876417 1.0 0.8627403580998321 12 P05067 1 +Inner ear auditory receptor cell differentiation 0.3979003254548237 0.3539176549189466 0.7234005955778322 1.0 0.8627403580998321 7 O95487 1 +Digestive system development 0.339585320701356 0.3500030803297378 0.7263363859220091 1.0 0.8652278298183592 12 P00813 1 +Axonal transport of mitochondrion 0.3727240045976877 0.3471390478504645 0.7284868594066451 1.0 0.8666034958616202 5 P27695 1 +Cellular response to xenobiotic stimulus 0.2989223139188044 0.344693239653782 0.7303250010002977 1.0 0.8675776714155893 25 O43169,O00170,Q96KQ7,P07099 4 +Lymphocyte activation involved in immune response 0.2989120771878329 0.3446290460881744 0.73037326644997 1.0 0.8675776714155893 25 O96028,P00813,Q9UQ84,Q96QE3 4 +Positive regulation of mitotic cell cycle phase transition 0.2860673789863926 0.3445964789062123 0.7303977532638166 1.0 0.8675776714155893 32 Q96DY7,P05067 2 +Receptor catabolic process 0.3849506636590067 0.3427147808056158 0.7318130419594109 1.0 0.8682439701919855 8 Q99538,Q00535 2 +Establishment of protein localization to telomere 0.3629468965876682 0.3423978369647698 0.7320515160885541 1.0 0.8682439701919855 10 P49368,P17987,P50991,Q99832 4 +Regulation of establishment of protein localization to chromosome 0.3629468965876682 0.3423978369647698 0.7320515160885541 1.0 0.8682439701919855 10 P49368,P17987,P50991,Q99832 4 +Positive regulation of establishment of protein localization to telomere 0.3629468965876682 0.3423978369647698 0.7320515160885541 1.0 0.8682439701919855 10 P49368,P17987,P50991,Q99832 4 +Vesicle cytoskeletal trafficking 0.321476478747409 0.3421863442661548 0.7322106613189492 1.0 0.8682707021162762 18 Q9Y4I1,P27695,O14617,P43034 4 +Nuclear membrane reassembly 0.3941956619705862 0.3407568858302783 0.7332866100324509 1.0 0.8685742999191685 7 O75531 1 +Protein polyubiquitination 0.2806851582373833 0.3368553223036946 0.7362259665178472 1.0 0.871406376757437 42 P55786,P19474 2 +Diol metabolic process 0.3928177774884599 0.3359113667786753 0.7369377051745909 1.0 0.8717617818890191 7 P35270 1 +Diol biosynthetic process 0.3928177774884599 0.3359113667786753 0.7369377051745909 1.0 0.8717617818890191 7 P35270 1 +Pigment granule organization 0.3376399028473479 0.3328959156210255 0.739212852639189 1.0 0.873153111201391 4 O14617 1 +Protoporphyrinogen ix biosynthetic process 0.3370930437146839 0.3308092909155682 0.7407885425229428 1.0 0.8744288130595569 4 P36551 1 +Atp synthesis coupled electron transport 0.2841165025536067 0.3306185715677688 0.7409326163358734 1.0 0.8744288130595569 34 Q9Y6M9,P20674,P00403,O14949,P09622,O95298,Q99497,O75251,P51970,Q9UDW1 10 +Golgi localization 0.366345819227786 0.3242930856584255 0.7457161539259873 1.0 0.8777355322876992 5 P60953 1 +Embryonic skeletal system morphogenesis 0.3797211576181152 0.3236082766602403 0.7462346210255613 1.0 0.8778580883284226 8 Q9UPW6 1 +Embryonic skeletal system development 0.3797211576181152 0.3236082766602403 0.7462346210255613 1.0 0.8778580883284226 8 Q9UPW6 1 +Regulation of anatomical structure morphogenesis 0.2397832649540881 0.3223458691944388 0.7471906874163858 1.0 0.878657541021008 143 Q9UQB8,P63167,Q9H2U1,Q9Y6C9,P09601,O14965,P35579,Q00535,Q6XZF7,P00813,P61586,Q7L576,P35580,P84095,P09493,P78527,Q9NZ08,O60828,Q99536,Q9P258,Q9Y4G8,O75844,Q969H8,Q92766,P52789,O95747 26 +Positive regulation of gtpase activity 0.2827611944459423 0.3219940794955364 0.7474571797422822 1.0 0.8788083304554098 35 P49815,Q9Y5X1,Q13526,P63244,P84095,P31751,Q9P258,Q9Y4G8 8 +Cell substrate junction organization 0.3053084078681207 0.3211154614711982 0.7481228937293651 1.0 0.8794283544560467 21 P61586,Q9P258,P63167 3 +Negative regulation of dna templated transcription elongation 0.3786953928899992 0.3199105996838447 0.7490361024204184 1.0 0.8800487624839747 8 Q00839 1 +Ephrin receptor signaling pathway 0.3015557762330274 0.3197922498229246 0.7491258231050764 1.0 0.8800487624839747 3 Q06124,Q15375 2 +Negative regulation of fatty acid metabolic process 0.3969625782830524 0.31960227962214 0.7492698460601859 1.0 0.8800487624839747 6 O00763,Q06481 2 +Negative regulation of actin filament polymerization 0.30498804584496 0.3193232192416208 0.7494814272066952 1.0 0.8800487624839747 21 P07737,Q05655,O15020,Q9UEY8,O95425,Q13045 6 +Membrane biogenesis 0.3170279333365097 0.3191220019185307 0.7496340001260797 1.0 0.8800653315111493 18 P41440,Q86XL3,O75531 3 +Maintenance of synapse structure 0.3646902947996157 0.3184679482141725 0.7501300036235841 1.0 0.880485005176639 5 Q14203,Q8IUD2,P56545,Q9BRK5 4 +Positive regulation of gene expression 0.2245379718895417 0.3174689917553039 0.7508877644693919 1.0 0.8812117117739022 210 Q567V2,O96028,Q6P1A2,Q7Z478,P26358,Q9H2U1,Q96AE4,Q14103,P09601,P35579,P14174,P08670,P98175,P61586,P17844,P41440,P05067,Q09161,Q00839,P04439,Q8NCA5,P78527,Q96PU8,O15111,O60828,Q9NUD5,O75844,Q96QE3,P98179,Q13595,P09429,O95747,P16989 33 +Cellular macromolecule localization 0.2328956485894726 0.3170361455025649 0.7512161757195992 1.0 0.881271689345473 510 P30536,O14976,Q99595,Q9H2U1,Q14108,Q9HD45,Q9Y6C9,P24390,Q99797,Q9Y282,Q96DY7,O43681,O60220,Q14141,Q5SRE5,O14965,P43307,Q9UHD1,Q9NS69,Q9Y584,P55786,Q00535,P55735,P49815,O95831,O60830,O00170,Q9Y4I1,Q9UI26,Q13526,Q5JRX3,Q9HD20,Q9UFC0,P41440,O60725,Q8IY18,O15118,Q00839,P27695,P09874,Q99805,O43805,O43865,Q9BZH6,Q8IYI6,Q99523,Q9BZE9,Q06481,O15260,P10619,Q9Y5J9,Q4V328,P31751,P13473,Q9Y3B3,Q68CQ4,O95429,Q9UH99,Q9Y4G8,P49257,P50542,P46379,Q9BZL1,Q9Y5L4,Q10713 65 +Head morphogenesis 0.3640278237827173 0.316149328229398 0.7518891668113907 1.0 0.8817170470764882 5 O95470,Q06124,Q15042,Q6KC79 4 +Regulation of defense response to virus 0.3197929425314378 0.3159875278217142 0.75201197485866 1.0 0.8817170470764882 17 Q92890,Q08211,Q15366,O60828,O43657,O75844 6 +Protein localization to chromosome telomeric region 0.3196049845012166 0.3150532803548772 0.7527212002730364 1.0 0.8822231143159541 17 P17987,P50991,Q99832,P46100,P49368,P13010,O14773,Q9BUR4,Q9NYB0 9 +Blastocyst development 0.2817831277252834 0.3147709690382861 0.7529355554281612 1.0 0.8823116501293127 32 Q92541,Q9Y3B4,Q86XI2,P00813,Q8IWS0,Q6RFH5 6 +Regulation by virus of viral protein levels in host cell 0.3327814569536339 0.3145520780701059 0.7531017694842204 1.0 0.8823437505698994 4 Q16531,P42224,Q9P035 3 +Lymphocyte mediated immunity 0.2817294678655273 0.3137416965952578 0.7537172292546463 1.0 0.8826301088226355 33 O96028,P04439,Q05655,P68371,P07437,Q9UQ84,P36915,P09429,P53634,Q96FZ2,Q96QE3 11 +Cell part morphogenesis 0.24470532098377 0.3132246822810147 0.7541099674983991 1.0 0.8828740013667018 111 Q9UQB8,Q9H2U1,P61586,P42892,Q06481,Q7L576,O14965,P41440,O60828,P05067,Q9Y4G8 11 +Epithelial tube formation 0.3079674062937407 0.3119532899752744 0.7550760222701531 1.0 0.8838422094933873 20 P49815,P25440,Q9BYW2,P07737,O60313,O95487,P63167,Q9ULT8,Q92990,Q13308,O95747 11 +O glycan processing 0.3945081106770869 0.3115571084592238 0.7553771352279519 1.0 0.8838924678898927 6 Q9H488,Q10472 2 +Response to inorganic substance 0.247488951576071 0.311530859038496 0.7553970870953268 1.0 0.8838924678898927 99 P30536,P27695,O95831,O43865,Q99720,P09601,Q92542,O60888,P05067,O15118 10 +Embryonic appendage morphogenesis 0.3660692911050308 0.3111456322454816 0.7556899120844434 1.0 0.8838991908131415 9 P42892 1 +Leukocyte cell cell adhesion 0.2801816762113789 0.3109744718328543 0.7558200286452839 1.0 0.8838991908131415 38 P04439,Q9HCL2,P00813,P61586,O14617,P09429 6 +Hydrogen peroxide catabolic process 0.3313577920849641 0.3092609943222519 0.7571229995520621 1.0 0.8849344952469487 4 P30044 1 +Epithelial cell proliferation 0.278620309879831 0.3085329578876395 0.7576768258250715 1.0 0.8852562325264989 40 Q969H8,Q8WTV0,P78527,Q92766,P09601,P09429,Q92542 7 +Synapse organization 0.2568908195794488 0.3064211914894743 0.7592839753945897 1.0 0.8866953620770317 63 Q9UQB8,P07737,Q9H2U1,P61586,Q13526,Q7L576,P10586,P05067,Q00535 9 +Striated muscle cell differentiation 0.2782974307610283 0.306163601686497 0.7594800841809048 1.0 0.8866953620770317 40 Q99523,Q8IV08,P09493,O75844 4 +Golgi to plasma membrane protein transport 0.3277785634515068 0.3052924925267614 0.7601433932805635 1.0 0.887159641515105 13 Q01082,O15027,P63244,P98194,Q9H4A6,Q9UPN3 6 +Negative regulation of protein tyrosine kinase activity 0.3838249293431444 0.3049676010902539 0.7603908281900988 1.0 0.8872854973336274 7 Q99816,O95684,P63244,Q86XI2 4 +Regulation of telomere maintenance 0.2798130615810931 0.3028064660085621 0.762037355469142 1.0 0.8883913116951333 36 P22626,P09874,Q9H2U1,Q9UPR3,P17987,P49750,Q99832,Q14103,P49368,P50991,P13010,Q93009,P28482,Q9NYB0,P27361,Q00839 16 +Regulation of telomere maintenance via telomere lengthening 0.2949228900458161 0.3026226917364834 0.7621774193779958 1.0 0.888391651855225 24 P22626,P09874,Q9H2U1,Q9UPR3,P17987,P50991,P49368,Q99832,P13010,P28482,P27361,Q00839 12 +Dna replication initiation 0.3019165858345696 0.3022994124122982 0.7624238262275189 1.0 0.8885117152715944 21 Q9Y619,Q14566,P09884 3 +Cell matrix adhesion 0.2905007872579203 0.3018875611320809 0.7627377784188458 1.0 0.8885117152715944 26 P61586,Q00535,P63167 3 +Regulation of proteolysis 0.238672484343307 0.3000705999429603 0.7641233042763922 1.0 0.8889679355433849 156 Q9BZF9,Q6P1A2,P63167,P46777,P63244,Q99538,Q96F07,O14965,P35579,Q9NZJ7,Q9UMY4,Q92542,Q9Y5A7,Q8NEZ5,Q00535,O95831,Q9C0D3,O43765,Q96JB5,Q5JVF3,Q9C0C9,Q96KB5,O43847,P61586,Q15392,Q9NR09,Q9Y4X5,P78318,P61289,O75832,P19474,P25788,P05067,Q92896,Q06481,Q99497,Q9GZP4,Q9Y5X1,Q96A26,P49327,P46379,P55072,P09429,P53634,P30044,Q93009,Q9Y5K5,Q96HY6 48 +Rho protein signal transduction 0.3014722250618439 0.2998607392675866 0.7642833825337507 1.0 0.8889679355433849 21 P41440,P61586,P63167 3 +Regulation of response to stress 0.2182556807297566 0.2952483938371532 0.7678041358505987 1.0 0.8920056822274548 228 P60900,O96028,Q6P1A2,P43034,P63244,Q9NYF8,Q9UHD1,Q9NYB0,P21333,O43765,P14174,Q96KB5,P00813,P55145,P78318,P57088,P17844,O75832,Q14166,P19474,Q99615,P05067,Q9BRJ7,P09874,P04439,Q05655,Q13769,P78527,Q9NZ08,Q06481,Q15366,O60828,Q9NUD5,O75844,Q96QE3,P49327,O75531,P46379,Q08211,Q92766,P09429,P53634,P08183,Q99873,P10586,P16989 46 +Unsaturated fatty acid biosynthetic process 0.3806293579413201 0.2942653266974518 0.768555165571347 1.0 0.892225868926298 7 P14174 1 +Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.2946044356173362 0.2920236334232519 0.7702685542948196 1.0 0.8936433382604743 3 P49840,P30419 2 +Vitamin a metabolic process 0.2634017207147676 0.2905110190076025 0.7714253221533456 1.0 0.8942512032840898 2 O94788 1 +Regulation of nuclear transcribed mrna poly a tail shortening 0.3564094070884583 0.290004656111166 0.771812675543923 1.0 0.894537083471403 5 P11940,Q9UPQ9,Q9UIV1,P62487 4 +Positive regulation of proteolysis 0.2455599617217145 0.289706621469975 0.7720406902719898 1.0 0.8946382182987725 90 Q9BZF9,Q6P1A2,P63167,P63244,Q99538,Q96F07,O14965,P35579,Q9NZJ7,Q92542,Q9Y5A7,O95831,Q9C0D3,O43765,P61586,P61289,O75832,P05067,Q9Y5X1,Q96A26,P49327,P46379,P09429,P53634 24 +Positive regulation of transmembrane transport 0.2866271339408913 0.2880841026172362 0.7732823612939856 1.0 0.8953871928331072 27 Q9UHD1,P27695,Q00535,P08183 4 +Positive regulation of immune effector process 0.2779153363062838 0.2875284509418765 0.7737077205090463 1.0 0.8955063832088263 34 O96028,P04439,P14174,Q9H2U1,Q06481,P09601 6 +Cytokine production involved in inflammatory response 0.3867439033842865 0.2866743445622404 0.7743616835028897 1.0 0.895857819502069 6 Q8IV08 1 +Endomembrane system organization 0.2377189872108616 0.2862654960074086 0.7746747829740337 1.0 0.8960569464209205 157 Q9UQB8,O14976,Q6P1A2,Q14108,O43681,Q7RTS9,Q9Y4I1,P57088,P41440,Q96ED9,O95197,Q8IYI6,O15260,P31751,Q9UH99,O75844,Q86XL3,P49257,O75531,P50542,P46379 21 +Fibroblast migration 0.3186870373279291 0.2839077525647002 0.776481075174448 1.0 0.8974929466828134 15 Q06481,Q5SNT2,O95429 3 +Rna polyadenylation 0.2772535719065088 0.283189050466914 0.7770319214193762 1.0 0.8976087342749471 33 O43865,Q5KU26,Q96MU7,Q09161,P05067 5 +Hepaticobiliary system development 0.2770192886784741 0.2820099498861915 0.7779358809228976 1.0 0.8981822973660771 35 P11717,P00813,Q14103,P09601,O14965,O75844 6 +Polyol catabolic process 0.3768578760377765 0.2818393897909945 0.7780666660317213 1.0 0.8981822973660771 7 Q01968,Q10713 2 +Ribosome associated ubiquitin dependent protein catabolic process 0.3538233333799905 0.2813524989589026 0.7784400474380146 1.0 0.8984068082862333 5 Q9H1I8,Q8N3C0 2 +Multicellular organism growth 0.2831728962854917 0.2785481905807986 0.7805915773770966 1.0 0.9000622906244512 30 P50542,P05067,Q9BZH6,O75844 4 +Short chain fatty acid catabolic process 0.290963257199594 0.2779342500571751 0.7810628315534052 1.0 0.9001696024212953 3 P05166,Q16822 2 +Short chain fatty acid metabolic process 0.290963257199594 0.2779342500571751 0.7810628315534052 1.0 0.9001696024212953 3 P05166,Q16822 2 +Locomotory behavior 0.2856013397300795 0.274593163532974 0.7836288192223428 1.0 0.9013291304699984 29 P05067,O15118,O75844 3 +Regulation of megakaryocyte differentiation 0.3827622524773786 0.2742579008189736 0.7838864347838674 1.0 0.9014623085735954 6 Q96T37,Q9GZP4 2 +Er nucleus signaling pathway 0.3221932984437057 0.2740538263662603 0.7840432570056648 1.0 0.901479548033286 12 Q6P1A2 1 +Regulation of microtubule depolymerization 0.3820874043066437 0.2721771342698416 0.785485822587878 1.0 0.9024851569719002 6 Q66K74,Q9ULW0 2 +Inorganic ion transmembrane transport 0.2433525289626742 0.2712243979016262 0.7862184492115276 1.0 0.903000445100916 104 P00846,P27695,P00403,Q9HC07,Q13423,Q9HD20,P31930,Q9UHD1,Q9UHG3,Q9UBX3,Q9UDW1,Q15043,P21796 13 +Positive regulation of calcium ion transmembrane transport 0.3444323999236583 0.270364710711636 0.7868796862384833 1.0 0.903386920512058 10 P27695 1 +Cardiac muscle cell contraction 0.3442040991520215 0.2695182915079768 0.7875308682313984 1.0 0.9038544959333276 10 P21333,Q13557 2 +Kidney morphogenesis 0.3728904099878557 0.2690130033555982 0.7879196761769085 1.0 0.9038565297860992 7 O75844 1 +Histone h2a ubiquitination 0.3728234063666299 0.2687985817665598 0.7880846847783038 1.0 0.9038565297860992 7 P63208,Q96FW1,Q8IWV8 3 +Regulation of mrna polyadenylation 0.3192747927425842 0.268386522354384 0.7884018126916252 1.0 0.90403787145372 13 Q09161,Q96MU7 2 +Activated t cell proliferation 0.3807471071484395 0.2680651790554249 0.7886491482891052 1.0 0.9041583669779136 6 Q9HCL2 1 +Extrinsic apoptotic signaling pathway via death domain receptors 0.3169839866751152 0.266527135273811 0.7898332640175232 1.0 0.9051893664073888 14 Q99523 1 +Endonucleolytic cleavage involved in rrna processing 0.319844852532242 0.2643378382891466 0.7915196061084799 1.0 0.9062368622918422 12 Q5SY16,Q14137 2 +Dna methylation dependent heterochromatin assembly 0.3195527402074562 0.2631387859908131 0.7924436101220669 1.0 0.9064976370854873 12 Q9Y6X9,P26358 2 +Regulation of binding 0.2433237840238499 0.26255484194735 0.7928937100285689 1.0 0.9065717612774932 92 Q86X55,P63244,P09601,O14965,Q00535,Q13526,P62826,P19474,P41440,Q96D46,Q09161,P05067,Q08379,P09874,Q05655,Q99497,Q9Y4G8,O75844,P35611,Q08211,P09429,O75503,P10586,Q96HY6 24 +Regulation of peptidase activity 0.2438945289111914 0.2622002550801582 0.7931670567444393 1.0 0.9067211893287151 77 Q9BZF9,P63167,P63244,Q99538,Q96F07,Q9NZJ7,Q92542,O95831,Q9C0C9,Q5JVF3,O43847,P61586,Q15392,P61289,P05067,Q06481,Q96A26,P49327,P09429,P30044,Q9Y5K5 21 +Regulation of mitotic cell cycle 0.235154821604333 0.2603469348151676 0.7945961716944754 1.0 0.907634384865228 122 P27695,Q5JVF3,Q9NPI1,Q13526,P78527,P61289,Q06481,Q96DY7,Q14166,O14965,Q9Y619,Q7Z7L1,P05067,Q00839,O75844 15 +Hematopoietic progenitor cell differentiation 0.2873957435047117 0.2592600346811086 0.7954346130893628 1.0 0.9076384504619652 24 P78527,Q9NPH0 2 +Positive regulation of organelle organization 0.2355670852135075 0.2588577734764716 0.7957449797961726 1.0 0.9076384504619652 145 Q9UQB8,P26358,Q9H2U1,Q14103,O14965,Q00535,P21796,P07737,P61586,Q7L576,Q8IY18,P09493,P27695,O15260,P31751,Q9UK61,O95429,Q9Y6X9,P49257 19 +Appendage morphogenesis 0.3296882433519087 0.2565326693909497 0.7975395576753626 1.0 0.9087775956587674 11 P42892 1 +Spinal cord development 0.3295870438056978 0.2561447527900313 0.7978390666086741 1.0 0.9089287579881185 11 O75312,O75530,Q8NCM8,P25325,Q14203,Q9UKA9 6 +External encapsulating structure organization 0.2909873776887693 0.2540191944855151 0.7994807292995019 1.0 0.9093364747158827 22 P05067,P41440 2 +Regulation of nuclear division 0.2720701329579693 0.2540082676696844 0.7994891708592473 1.0 0.9093364747158827 38 Q69YH5,Q5JVF3,P30260,Q13526,P46013,P50748,Q96DY7,O14965 8 +Positive regulation of interferon beta production 0.3399269804127701 0.253859933719605 0.7996037692238938 1.0 0.9093364747158827 10 Q06124,Q08211,P41440 3 +Establishment of endothelial intestinal barrier 0.358914352186239 0.2520201191079149 0.8010255128142088 1.0 0.910311429407175 8 Q9Y4G8 1 +Mitochondrial electron transport nadh to ubiquinone 0.29645176885668 0.2519664077935281 0.8010670289439574 1.0 0.910311429407175 20 P51970,P09622,O95298,O75251 4 +Negative regulation of cell adhesion 0.2806508819686303 0.2518239079265531 0.8011771768571014 1.0 0.910311429407175 27 Q05655,P63167,P61586,P09429,Q9BTW9 5 +Positive regulation of cell cycle phase transition 0.2696305496383315 0.2492929724241376 0.8031341669566998 1.0 0.9120458755005868 41 Q13769,Q96DY7,P05067 3 +Protein localization to nuclear body 0.3274344688248656 0.247949226507406 0.8041736915901088 1.0 0.9127842240973008 11 P49368,P17987,P50991,Q99832 4 +Immune system development 0.234903913778333 0.2474412815249755 0.8045667292001908 1.0 0.9130201983210876 147 Q03164,O96028,Q9H2U1,P24390,Q9NPH0,P35579,Q5JVF3,P00813,P61586,P05067,P09874,O96005,Q13769,O14617,P78527,Q9GZP4,Q96QE3,O75844,P49327,Q86XI2,Q04760,Q9UQ84,P09429,Q96T37,Q14739,Q99873,Q6IBW4 27 +Negative regulation of erad pathway 0.2826878517047236 0.2471335774072373 0.8048048484914356 1.0 0.91305442085082 3 Q04323,O43765 2 +Regulation of collateral sprouting 0.2823568354849293 0.2459377900523562 0.8057303898247148 1.0 0.9138512415642196 3 Q8N0X7,Q15375 2 +Intracellular transport 0.2313448070951267 0.2452676920313295 0.8062491658701201 1.0 0.9139148521323344 522 P30536,O14976,Q99595,P11717,Q14108,Q14849,P24390,Q99797,Q9Y282,O43681,O60220,Q5SRE5,P43307,Q9UHD1,Q9NS69,Q9Y584,P55786,Q9NZJ7,Q00535,P55735,P49815,O95831,O60830,O00170,Q5JVF3,Q9Y4I1,Q9UI26,Q5JRX3,O43772,P07602,Q08J23,O60725,Q96ED9,Q5SNT2,P05067,Q09161,O15118,Q00839,P27695,O43805,O43865,Q9BZH6,Q13769,Q99523,Q9BZE9,Q06481,O15260,P10619,Q9Y5J9,Q4V328,P31751,P13473,P61916,O95429,Q9UBX3,Q9UH99,O75844,P00846,P49257,P50542,P45880,P46379,Q96MU7,Q9BZL1,Q9Y5L4,P84103,Q10713 67 +Meiotic chromosome separation 0.3730947647448581 0.2451224437317286 0.8063616253552754 1.0 0.9139148521323344 6 Q02880,Q15003,Q14674,P33981,Q6IBW4 5 +Macromolecule catabolic process 0.2141363940504956 0.2441486329555937 0.8071157082837317 1.0 0.9143643629792176 397 O60506,Q9NUJ1,P46777,P63244,Q969T7,Q9Y2C4,Q9UHG3,Q9UMY4,Q9Y5A7,Q86UV5,O95831,P21333,O43765,O43847,P49721,P28074,Q8N511,Q16850,Q8N3C0,Q92804,P10619,Q99497,Q96DE0,Q9UBV2,Q9UPR3,O75844,Q7Z6E9,P46379,Q9UIQ6,O00462,P55072,P16278,Q93009,Q86Y37,P16989,Q96HY6,P15586,Q9UK45,Q9Y333,Q9Y3B2,Q6P6C2,Q8NEZ5,Q9NPD3,Q92890,P08670,Q96JB5,Q5JVF3,Q9Y4X5,Q15287,Q5T4S7,Q08J23,P25788,O60502,O94966,Q9BRJ7,P27695,P63208,Q6NZY4,Q8ND04,Q8WUX9,Q92990,Q9Y263,P50897,Q68CQ4,Q8IWV8,P53634,Q92945,P60900,Q9H2U1,Q14103,O14965,Q6PGP7,Q00535,P98175,Q13526,P61289,P17844,O75832,Q09161,Q00839,P20618,Q15366,P13473,Q9GZP4,Q9H7D7,Q15369,O75503,P52272,Q96NT0,Q9H1I8,Q99538,Q9C0D3,Q96KB5,O00178,Q05655,P08236,A0AVT1,P35573,Q99570,Q9Y5X1,P30260,Q08211,Q9Y5K5 103 +Cellular homeostasis 0.23262835259551 0.2433939277588346 0.8077002473475725 1.0 0.9143643629792176 132 Q96NT0,P09601,Q9UHD1,Q00535,Q15043,Q93050,P09622,Q9HD20,P05067,P27695,Q8N511,Q9Y487,P50897,P13473,Q9HC07,Q13557,P09429,P52789,P30044,O75503 20 +Imp biosynthetic process 0.3561007957559703 0.2429191830848917 0.8080680046492437 1.0 0.9143643629792176 8 P30566,P00492,P22234,P31939,P22102,P07741,Q06203 7 +Interferon gamma production 0.3720821552164357 0.2421558381868599 0.8086594127828703 1.0 0.9143993377952728 6 P04439 1 +Regulation of signaling receptor activity 0.30679978452348 0.2416252684572839 0.8090705407440346 1.0 0.9143993377952728 16 Q05655,Q86XI2,P41223,Q99816,Q99497,P05067 6 +Nucleoside phosphate biosynthetic process 0.2415813896859591 0.2415989727345737 0.8090909181498764 1.0 0.9143993377952728 95 P00846,P09874,P00403,Q8TB61,P32321,P00813,P04818,P50897,P09622,Q9UMR5,P55263,P43490,Q9NZ01 13 +Mrna export from nucleus 0.2683423604086923 0.2403272162839584 0.8100765976324233 1.0 0.914862625186866 41 Q5JVF3,Q13769,Q96MU7,Q08J23,P84103 5 +5s class rrna transcription by rna polymerase iii 0.3407794147318683 0.2395175028061823 0.8107043261061246 1.0 0.9151330369814652 5 Q8WUA4 1 +Base excision repair gap filling 0.3542175787962101 0.2369087179675406 0.8127276065387736 1.0 0.9162219332020094 8 P27695,P28340 2 +Osteoclast differentiation 0.3625572216102771 0.2368301998370084 0.8127885218547612 1.0 0.9162219332020094 7 Q04760 1 +Telomere capping 0.3244131695649281 0.2366277816175247 0.8129455655827504 1.0 0.9162219332020094 11 Q9NYB0,P78527,Q14103 3 +Cerebellar cortex development 0.3114844233595188 0.2361731364313249 0.8132983239656604 1.0 0.9162219332020094 13 Q5KU26,O15020,Q00535,O14949 4 +Positive regulation of catabolic process 0.2330788694406009 0.2352740706180301 0.81399601896665 1.0 0.9165403712821284 138 O60506,O00267,Q9H2U1,P63244,Q14103,Q969T7,P09601,O15269,O14965,Q9Y5A7,P21796,P49815,Q9Y6K9,Q9C0D3,O43765,O00178,O75832,P19474,P05067,Q00839,Q05655,P31751,Q9Y5X1,P46379,Q08211,P09429,P53634,Q92945 28 +Negative regulation of map kinase activity 0.3616410136762777 0.2340644092771181 0.8149349757739421 1.0 0.9172828571500086 7 Q05655,P31689,Q96JB5 3 +Response to fatty acid 0.333878557443636 0.2323767232929087 0.8162454262715755 1.0 0.9172828571500086 10 O15228,P11802,P13010,P23378 4 +Leukocyte mediated immunity 0.2634154729560002 0.2321675501320274 0.8164078804369546 1.0 0.9172828571500086 45 O96028,P04439,P68371,Q9H2U1,Q9UQ84,P09601,P36915,P53634,Q96QE3 9 +Regulation of erad pathway 0.3685802959796105 0.2320240716258532 0.816519317464397 1.0 0.9172828571500086 6 P46379,O43765 2 +Placenta development 0.2924083726726685 0.2319209019283572 0.8165994496996425 1.0 0.9172828571500086 20 Q13263,Q9BYW2,Q9ULT8,P00813,Q9NR09,P62753,P28482,Q96T37,P35613,Q12830 10 +Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna 0.3381914541238913 0.2315882104302841 0.8168578653106502 1.0 0.9172828571500086 5 Q86U38,Q12788,P78316,O75691 4 +Fatty acid biosynthetic process 0.2786230503577934 0.2315319997219603 0.816901528521232 1.0 0.9172828571500086 26 Q8IVS2,P14174,O95864,Q96PU8,Q15185,Q9NZ01 6 +Nucleoside bisphosphate metabolic process 0.2644232556495614 0.23152286339431 0.816908625468203 1.0 0.9172828571500086 44 Q8TB61,Q9HCL2,P50897,P09622,Q9UMR5,Q9NZ01,Q9UKG9 7 +Organic acid biosynthetic process 0.2477444635171164 0.2308669796497232 0.8174181442112587 1.0 0.9176103363840976 71 O14880,Q8IVS2,P49327,P14174,Q9BZF3,P00367,O95864,P34897,P34896,Q96PU8,O15382,Q99497,Q9NZ01,Q15185,Q13126,P32929 16 +Positive regulation of response to biotic stimulus 0.2689346171958154 0.2300867705245574 0.818024344730576 1.0 0.9179665845881958 32 P14174,P78527,O60828 3 +Telencephalon development 0.2685739068651669 0.2282578975615818 0.8194457534643322 1.0 0.9186222433177876 37 Q9Y5K5,O14949,P50542,P61586,P62826,A0AVT1,Q96N66,Q00535 8 +Synaptic vesicle recycling 0.3010654156272812 0.227715216015902 0.8198676425192917 1.0 0.9186222433177876 17 Q4V328,O14976,Q7L576,Q00535 4 +Protein modification by small protein conjugation 0.2337136326683462 0.2274320014995973 0.8200878385920245 1.0 0.9186222433177876 153 P30536,P46777,P63244,P29144,Q86WB0,Q8TBC4,Q96DY7,P60953,Q9UHD1,Q9NT62,P55786,Q00535,Q9Y5A7,Q8NEZ5,P61927,Q9C0C9,Q96JB5,Q9NR09,Q9Y4X5,Q13526,Q5T4S7,Q13867,O75832,P19474,Q9BTE7,P63208,Q92990,Q9Y263,A0AVT1,Q99816,Q99497,Q9UBV2,Q7Z6E9,Q9NV06,Q15022,O75448,P30260,P26368,P31689,Q9UIQ6,Q8IWV8,P55072,Q15369,P49792,Q93009,Q6DKJ4,Q96HY6 47 +Negative regulation of organelle organization 0.2394564298291162 0.2238136114673836 0.8229023382055887 1.0 0.9205389213719362 103 P30536,P49815,P09874,P07737,Q9UEY8,Q05655,Q5JVF3,P63167,Q96KQ7,O95425,Q96DY7,O75832,Q99536,Q9UIG0,Q9BTW9,Q00839 16 +Protein quality control for misfolded or incompletely synthesized proteins 0.3093947111427522 0.2227880932204045 0.823700435362853 1.0 0.9207365508152828 12 P46379,Q9C0D3,P55072 3 +Tube formation 0.2867459643191375 0.2227411337333803 0.8237369853875736 1.0 0.9207365508152828 21 P49815,P25440,Q9BYW2,P07737,O60313,O95487,P63167,Q9ULT8,Q92990,Q13308,O95747 11 +Inositol lipid mediated signaling 0.3022726329262125 0.2219710825796738 0.8243363945558237 1.0 0.9211466462371336 16 P49815,P42356,Q969H8,O00443,Q10713,Q9NV70,Q53EZ4,O15294 8 +Embryo development ending in birth or egg hatching 0.2327466649644754 0.2213848783927461 0.8247927656314675 1.0 0.9213367143347994 121 P25440,P63167,Q8WUW1,Q6RFH5,P35579,Q9H9Y6,Q92541,P49815,P07737,Q9Y3B4,Q9UPW6,P00813,O43772,Q08J23,P42892,P78527,Q9H488,Q01968,O95487,Q86XI2,Q96MU7,Q8IWS0,O95747,Q99873,P16989,Q9H0G5,Q6DKJ4 27 +Apoptotic signaling pathway 0.2309960799124522 0.2213802131832095 0.8247963978233179 1.0 0.9213367143347994 132 Q9BZF9,P09601,P49773,O95831,P14174,P61289,P17844,O75832,P32929,P09874,O75569,Q99523,P78527,Q96QE3,Q96A26,P45880,P46379,P53634,P16989 19 +Positive regulation of t cell proliferation 0.3398548633143642 0.2197478447027486 0.82606754058973 1.0 0.9219916218963696 9 P04439,Q9HCL2 2 +Regulation of endoplasmic reticulum unfolded protein response 0.3566882180697712 0.219367632048107 0.8263636818452396 1.0 0.9219916218963696 7 P63244,P57088 2 +Glycine metabolic process 0.3564770882310598 0.2187507670499954 0.826844200168809 1.0 0.9220305127432894 7 P34896,P23378 2 +Regulation of histone h3 k4 methylation 0.301430046509188 0.2183805239918801 0.8271326389524476 1.0 0.9220305127432894 16 Q92541,Q03164,O60341,P26358,Q96KQ7,P38398,P61964,O15294 8 +Steroid hormone mediated signaling pathway 0.2672673299651171 0.2183476212120403 0.8271582730746123 1.0 0.9220305127432894 33 P61586,P09874,Q86X55,Q15185 4 +Dna replication 0.2372953045784036 0.2177198815780016 0.8276473719941024 1.0 0.922413939399354 110 Q9BQ67,Q9BTE3,P55209,P60953,Q9NRF9,P35250,Q96KQ7,Q9BRT9,O95785,P46063,P41440,Q9UFC0,Q7Z7L1,Q01105,P33991,Q9NRG0,Q14566,Q9NR33,P09884,Q9NRL2,O75844,Q7Z6E9,Q96QE3,P28340,Q08211,P49736,Q07864,Q9Y5K5,Q9Y619 29 +Xmp metabolic process 0.3559827643354263 0.2173095937090698 0.8279670810374995 1.0 0.9224467602233736 7 P12268,P30566,P22234,P31939,P22102,Q06203 6 +Vesicle transport along microtubule 0.307769784822848 0.2165829725285562 0.8285333567312498 1.0 0.9226895676729594 12 P27695,O14617,P43034 3 +Regulation of dna binding transcription factor activity 0.2467371281035715 0.2156035733258358 0.8292967701999276 1.0 0.9231648059411904 63 P60900,P21333,Q9Y6K9,Q08211,Q96HY6,P09601,O75832,Q12888,P19474,P41440,Q9UHD1,Q99497,Q9NYB0,O15111,P05067,Q93009,P32929 17 +Microtubule anchoring 0.3470640829474223 0.2146832175226673 0.830014307987067 1.0 0.9235371582490732 8 O95684 1 +Regulation of rna export from nucleus 0.328611247394963 0.2143180647895969 0.8302990316460703 1.0 0.9235877922895386 10 Q9BYW2,P12270,Q08211,Q08J23,Q07666 5 +Regulation of mitotic cell cycle phase transition 0.2336780829427759 0.2138255016822928 0.8306831373796622 1.0 0.923646917951762 83 P27695,Q5JVF3,Q9NPI1,P78527,P61289,Q06481,Q96DY7,O14965,Q9Y619,Q7Z7L1,P05067 11 +Heart development 0.2313439263341767 0.2136908567673238 0.830788141902175 1.0 0.923646917951762 80 O96028,P63167,Q9H2U1,O00763,P60953,Q13308,O94788,P49815,P21333,P09493,Q00839,Q53GG5,Q9BZH6,Q8TD19,P42892,P78527,Q06124,Q9H488,O75844,O95487,P10253,P43243,P49840,O95747,Q96T37,Q99873 26 +Divalent inorganic cation homeostasis 0.2536927015592813 0.2125525588521304 0.8316759783391845 1.0 0.923841354353248 50 P27695,Q9HC07,Q13557,Q9HD20,P05067,Q00535,Q15043 7 +Regulation of cellular response to transforming growth factor beta stimulus 0.3066428791226549 0.212321213542376 0.8318564466811629 1.0 0.9238650314704652 12 Q92896 1 +Actomyosin structure organization 0.2580979144099172 0.211869670562856 0.8322087128185471 1.0 0.9240023052495424 47 Q15417,P07737,P63167,P61586,P35580,O95429,P09493 7 +Protein modification by small protein removal 0.261386357778007 0.2102820517027734 0.8334475427852259 1.0 0.9243501481418698 44 P49773,P19474 2 +Monoubiquitinated protein deubiquitination 0.3602556000485288 0.2087487209018545 0.834644404111017 1.0 0.9245437075560397 6 Q9Y4E8,Q9Y6J9,Q93009,Q15393 4 +Positive regulation of cellular component biogenesis 0.2365209217463508 0.2086424313991628 0.8347273839980809 1.0 0.9245437075560397 110 Q9UQB8,P27695,P26358,Q8NCA5,P61586,Q7L576,P41440,O95429,P09493 9 +Negative regulation of microtubule polymerization or depolymerization 0.3268082282680876 0.2082790733527996 0.8350110703976568 1.0 0.9245437075560397 10 P04350,O75122,P16949,Q8WWK9,Q92974,Q02790,Q9ULW0,Q15691,Q9BTW9 9 +Protein maturation by protein folding 0.3301410587617922 0.2077400987233119 0.8354319063694369 1.0 0.9246047704830472 5 O00170 1 +Positive regulation of chromosome organization 0.257324388588068 0.2063392824823805 0.8365258956967732 1.0 0.925365040254356 47 P26358,Q9H2U1,P17987,Q14103,Q99832,Q15047,Q13263,P12270,Q8NEY8,P49368,Q8IY18,Q15021,P22626,P24941,P50991,Q9UK61,Q9Y6X9,P23246,P13010,P28482,P27361,P35222 22 +Nucleobase containing small molecule metabolic process 0.2277172277508559 0.205515347505212 0.8371695084345236 1.0 0.925365040254356 186 P00403,Q8TB61,Q9HCL2,Q969T7,Q9H773,P49773,Q13126,P00813,P61586,P04818,P09622,P55263,O60725,P05067,P84090,P09874,P32321,P50897,Q96DE0,P43490,Q9NZ01,Q9UKG9,P04183,P00846,Q9UMR5 25 +Negative regulation of intrinsic apoptotic signaling pathway 0.2652047965783689 0.2048026562489263 0.83772631161722 1.0 0.9255324937665652 34 P45880,P14174 2 +B cell mediated immunity 0.2930541017091033 0.2045911945859882 0.8378915355875292 1.0 0.9255541536660298 18 Q05655,O96028,Q9UQ84,Q96FZ2,Q96QE3 5 +Peptidyl serine dephosphorylation 0.3581842279655333 0.203138103583421 0.8390270902022299 1.0 0.926647469213792 6 P62136,P63151,P53041,P30153,Q08209 5 +Mrna 3 end processing 0.2642967254149344 0.2025917292073413 0.8394541550882311 1.0 0.9269580628458646 38 O43865,O00267,Q9H2U1,Q5KU26,Q96MU7,Q09161,P05067 7 +Negative regulation of mitotic cell cycle 0.2521994990785252 0.2014674084825185 0.8403331111902439 1.0 0.9273296890864082 50 Q5JVF3,Q9NPI1,P78527,Q96DY7,Q9Y619 5 +Interferon beta production 0.3146164394121624 0.2014229884927803 0.8403678413390265 1.0 0.9273296890864082 11 O75955,Q7Z434,Q86UT6,Q08211,P41440,Q06124 6 +Positive regulation of leukocyte chemotaxis 0.3144223744608518 0.2007494584370291 0.8408944846107811 1.0 0.9274729546571197 11 P09429,O95747 2 +Female meiotic nuclear division 0.3422626611512483 0.2003156427611669 0.8412337293263521 1.0 0.9274729546571197 8 O14965 1 +Ras protein signal transduction 0.2449632277963965 0.2000641528851643 0.8414304084096196 1.0 0.9275289066686684 64 P26358,P61586,Q15392,Q7L576,Q9Y4G8 5 +Hindbrain morphogenesis 0.3333081676917991 0.1990491347437924 0.8422243095488271 1.0 0.9281938008374928 9 Q06124,O15020,Q00535,P63167 4 +Ribose phosphate biosynthetic process 0.2297494294767229 0.197523752889009 0.84341769546262 1.0 0.9282221181802962 80 P00846,P09874,P00403,P00813,P50897,P09622,Q9UMR5,P55263 8 +Mammary gland epithelium development 0.3412606306834991 0.1973740675459681 0.8435348215457479 1.0 0.9282221181802962 8 P31751 1 +Schwann cell development 0.348854393830628 0.1970172760905834 0.8438140183789073 1.0 0.9282221181802962 7 P31751,Q00535 2 +Monosaccharide catabolic process 0.3009692330024993 0.1952787025927523 0.8451747689765683 1.0 0.9292390298590328 13 P16278 1 +Muscle cell development 0.2721111931115558 0.1944984824700034 0.8457855838536283 1.0 0.9293531168154856 29 O60341,Q8NEZ5,Q14315,Q13045,P49840,O43707,O75083,P06493,Q08209,P09493,Q00839,O75844 12 +Substrate adhesion dependent cell spreading 0.2844973384984454 0.1943433790317536 0.845907021524611 1.0 0.9293531168154856 20 P21333,P11047,P61586,Q92766,Q9P258 5 +Cochlea development 0.3249632881381261 0.1930712298302382 0.8469031839842482 1.0 0.9293531168154856 5 P43034,P49736 2 +Head development 0.2307244593243498 0.1920653464065528 0.8476910190786409 1.0 0.9295935329992824 145 Q9UQB8,O14949,P12277,P63167,Q14103,Q92542,Q00535,Q9UPW6,P61586,Q5KU26,P62826,Q66K74,P05067,P27695,O75569,Q9BZH6,O15027,P78527,P50897,A0AVT1,Q96N66,Q9UKA9,Q9Y4G8,O95487,P50542,P46379,O75503,Q9Y5K5 28 +Positive regulation of release of cytochrome c from mitochondria 0.3244305695017816 0.1915923111441199 0.8480615657572361 1.0 0.929775686762646 5 Q96A26 1 +Actin filament depolymerization 0.2801037493855633 0.1904781912814609 0.8489344311679672 1.0 0.930315042155793 21 P35612,O15020,Q9UEY8,P35611,O95425,Q13045,O75083,P60981 8 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.3239483272606863 0.1902584363266556 0.8491066217126813 1.0 0.930343335219066 5 P13674,O15460,Q13162,P07237 4 +Nik nf kappab signaling 0.283222294006214 0.1884977298895827 0.8504864949071127 1.0 0.9312131200051004 20 P61586 1 +Myeloid leukocyte mediated immunity 0.3000714207987163 0.1881598211704884 0.850751367936315 1.0 0.931342696280265 12 Q9H2U1,Q9UNH7,P09601,O75083,Q92499 5 +Regulation of hematopoietic progenitor cell differentiation 0.3376610624041136 0.1869712429114119 0.8516831801507443 1.0 0.9320417171208902 8 P78527 1 +Telomere maintenance via telomere lengthening 0.2617426419837515 0.1847431900525227 0.853430468448128 1.0 0.932682615264773 37 Q9H2U1,P17987,Q99832,Q9NYB0,Q9NX24,P49368,P41440,Q15185,Q00839,P22626,P09874,Q9NVN8,P50991,Q9BUR4,Q9UPR3,P13010,P28482,P27361,P35222 19 +Phosphatidylinositol 3 kinase signaling 0.3094538645935294 0.1838295695121131 0.8541471583122375 1.0 0.9329990822285004 11 P49815,Q10713 2 +Cell cell adhesion 0.2356209449095583 0.1833282220349645 0.8545404916576849 1.0 0.933080117673294 90 Q9UQB8,P04439,Q15417,Q05655,Q9HCL2,P00813,P61586,O14617,P09429,Q96F07,P35579,P41440,Q9H4A6,P10586 14 +Negative regulation of protein containing complex assembly 0.2597758019031513 0.1831281138212353 0.8546974971289951 1.0 0.9330912558831832 41 P07737,Q05655,O15020,Q9UEY8,P35611,P50542,P45880,O95425,Q13045,P09429,Q99497,Q9BTW9 12 +Pyrimidine nucleotide metabolic process 0.2905098173750985 0.1826210847456952 0.855095339322379 1.0 0.9332050097412502 17 P17812,P32321,P34896,P04818,P27708,Q9H773 6 +Columnar cuboidal epithelial cell development 0.3498757211037616 0.1813753566296523 0.856072960624874 1.0 0.9338014201214844 6 P49327,P04818 2 +Histone lysine demethylation 0.3491801238314505 0.1796079532003731 0.8574603604738145 1.0 0.9342206519956776 6 Q9H6W3,Q8NB78,Q7LBC6 3 +Regulation of dna templated transcription initiation 0.2975293791296923 0.1791357914377675 0.85783107902343 1.0 0.934425764913954 12 O75448,Q9H2U1,P11802,P09429,Q9NYF8 5 +Positive regulation of interleukin 6 production 0.3348022773362716 0.1788940426056871 0.8580209006413211 1.0 0.9344723859623436 8 P09429,P05067 2 +Regulation of cellular response to heat 0.3479438321523003 0.1764877825849661 0.8599107461173425 1.0 0.9357491235148836 6 Q9UHD1 1 +Defense response to symbiont 0.2416491720161898 0.1761221028088417 0.8601980168088845 1.0 0.9358813068875846 61 Q9HCL2,Q9H2U1,Q15366,P19474,O60828,Q7Z7L1,Q9NUD5,Q09161,O75844 9 +Negative regulation of amyloid precursor protein catabolic process 0.3255926329750132 0.1758255224276731 0.8604310179926753 1.0 0.9359032732324696 9 P27695,Q13526 2 +Positive regulation of telomere maintenance 0.2716125381899895 0.1753821156866427 0.8607793924015155 1.0 0.9359032732324696 24 P22626,Q9H2U1,P17987,P50991,Q99832,P49368,Q14103,P13010,P28482,P27361,P35222 11 +Pigment cell differentiation 0.2904540402086604 0.1753467295815148 0.8608071956131242 1.0 0.9359032732324696 4 O14617 1 +Import across plasma membrane 0.2861630407595079 0.1750522002232391 0.8610386169236173 1.0 0.9359947749557912 18 Q15043,P41440 2 +Regulation of osteoblast differentiation 0.3328418789141553 0.1734506667042518 0.8622972023115822 1.0 0.9364583329950972 8 P17844,Q9H6W3 2 +Ribonucleoside triphosphate metabolic process 0.2598295710011197 0.1730264824588599 0.8626306115701521 1.0 0.9364583329950972 37 P00846,P09874,P00403,P56134,P61586,P62826,O00178 7 +3 utr mediated mrna stabilization 0.3396252780293738 0.1721373786809257 0.8633295273988932 1.0 0.9365733692810184 7 P16989 1 +Protein deneddylation 0.3323602073171303 0.1721251919337812 0.8633391080266657 1.0 0.9365733692810184 8 Q9UBW8,Q7L5N1 2 +Epithelial tube morphogenesis 0.2596280287238445 0.1711232662129982 0.8641268419063635 1.0 0.9369651146104792 34 P49815,P07737,O95487,P63167,P61586,O95747,Q96T37 7 +Nucleobase biosynthetic process 0.2874607131579204 0.1702723182210877 0.8647959802045739 1.0 0.9375137728433006 17 P17812,P34897,P00813,P34896,P27708 5 +Nuclear envelope organization 0.267187449848524 0.1693136398165632 0.8655499478498716 1.0 0.937898972929851 26 O75531,Q9UH99,O75844 3 +Establishment of mitochondrion localization 0.3132955404189628 0.1654151141263377 0.868617258193431 1.0 0.939732986055736 10 P27695,Q66K74 2 +Neuromuscular process 0.265930983291873 0.1644955015479744 0.8693410877583929 1.0 0.9400360588282316 28 P05067,O75844 2 +Glucocorticoid metabolic process 0.285430463576149 0.1615203562899982 0.871683579851962 1.0 0.9420882219927004 4 P51608,Q9UNE7,P05023 3 +Negative regulation of peptidase activity 0.2579028203215995 0.1606913380034286 0.8723365120457904 1.0 0.9424733759243658 36 Q9C0C9,Q5JVF3,Q15392,P78318,Q06481,P30044,Q9Y5K5,P05067 8 +Regulation of amyloid precursor protein catabolic process 0.2920798380211244 0.1604112685963147 0.8725571135087831 1.0 0.942551497869107 12 P27695,Q13526 2 +Cellular pigmentation 0.3114187699470822 0.1598044975330787 0.8730350810974965 1.0 0.9425872219221484 10 Q9Y4I1,Q9H267,O14617 3 +Cardiac conduction 0.2878980013073342 0.1572560636735718 0.8750430454649176 1.0 0.9439747088753684 15 P21333,Q13557,O75844 3 +Positive regulation of translational initiation 0.3103634206836723 0.1566870251515868 0.8754915131977852 1.0 0.9439747088753684 10 Q07666,Q7Z478,Q13144 3 +Regulation of protein modification by small protein conjugation or removal 0.2357998839176547 0.1564945792053299 0.8756431917694685 1.0 0.9439747088753684 76 P30536,P61927,Q13526,Q96DY7,P19474,Q9UHD1,Q00535,Q6DKJ4 8 +Ubiquitin recycling 0.2545514730221677 0.156128063667246 0.8759320779996986 1.0 0.9439747088753684 3 Q9Y263,P14735 2 +Nucleobase metabolic process 0.2695372859896112 0.1559760489414493 0.8760519003127283 1.0 0.9439747088753684 23 P17812,P34897,P00813,P34896,P04818 5 +Rna localization 0.2288554398849959 0.1551849890080628 0.876675481960338 1.0 0.9439747088753684 118 Q9H2U1,Q92621,Q5SRE5,Q15388,P55735,Q5JVF3,P62826,Q08J23,P41440,Q09161,Q00839,Q13769,Q96PU8,P51991,Q8NFH4,Q96MU7,Q9BTX1,Q92945,P84103 19 +Positive regulation of protein dephosphorylation 0.2867655176200454 0.1531456639071248 0.8782834059901403 1.0 0.9449049944429704 15 Q13526,Q05655,Q86XL3,P63167 4 +Glial cell differentiation 0.2559240532615164 0.1529391249372691 0.8784462815982408 1.0 0.9449049944429704 39 P08670,P61586,P05067,Q92542,Q00535 5 +Regulation of cellular carbohydrate metabolic process 0.2638936147067994 0.152485788294309 0.8788037986586685 1.0 0.9451230024153126 26 Q14108 1 +Maturation of 5 8s rrna 0.2642590900761488 0.1516871561204498 0.8794336878741784 1.0 0.945207785721508 29 Q9Y4W2,P78527,O00541,Q14137,Q5SY16 5 +Positive regulation of response to cytokine stimulus 0.3085224810715766 0.1513138990902344 0.879728105633298 1.0 0.945207785721508 10 Q08211,Q99943 2 +Peptidyl proline hydroxylation 0.3242705570291796 0.1505772645962457 0.8803091970989845 1.0 0.945207785721508 8 P13674,P07237,O75718,Q13162,Q32P28,O15460,Q8N543 7 +Cardiac muscle cell action potential involved in contraction 0.3370091801206228 0.1500780205671482 0.8807030606175164 1.0 0.945207785721508 6 P21333 1 +Dendritic cell migration 0.2810613155532278 0.1499916105478187 0.8807712341946459 1.0 0.945207785721508 4 P09429 1 +Regulation of cellular component size 0.2264515072714268 0.1498774751502217 0.8808612831891074 1.0 0.945207785721508 82 Q9UQB8,P07737,O15020,O15143,Q9UEY8,Q05655,P43034,Q8WUW1,P61586,O95425,Q13045,Q7L576,Q96F07,O95429,Q00535,Q9Y5X1 16 +Negative regulation of hydrogen peroxide mediated programmed cell death 0.2522377274397621 0.1496429047574638 0.8810463561837778 1.0 0.945207785721508 3 Q99497 1 +Regulation of hydrogen peroxide mediated programmed cell death 0.2522377274397621 0.1496429047574638 0.8810463561837778 1.0 0.945207785721508 3 Q99497 1 +Programmed cell death in response to reactive oxygen species 0.2522377274397621 0.1496429047574638 0.8810463561837778 1.0 0.945207785721508 3 Q99497 1 +Cell cycle g1 s phase transition 0.2363307683728807 0.1492289283485622 0.8813729940396078 1.0 0.945207785721508 56 P27695,Q9NPI1,P11802,P61289,P62753,P78527,Q06481,Q96DY7,Q07864,Q8N6R0,Q86Y37,Q7Z7L1,Q00535,Q96HY6 14 +Membrane disassembly 0.3081400365650308 0.1491647133349575 0.8814236631185446 1.0 0.945207785721508 5 P43034,Q99986 2 +Positive regulation of plasma membrane bounded cell projection assembly 0.2661174966712375 0.1486289497382917 0.881846428138038 1.0 0.945207785721508 24 P07737,Q7L576,P27695,Q8NCA5 4 +Viral rna genome replication 0.2833801928483136 0.1468221163680077 0.8832724275243569 1.0 0.9457681181510802 16 Q15366,Q15365,Q9Y6X9 3 +Cellular response to abiotic stimulus 0.2377489002879714 0.1457147317511979 0.8841465912475661 1.0 0.9462593333091744 61 P30536,Q05655,P09874,P49327,Q9H2U1,Q96KB5,P31751,O95747,P09884,Q9UHD1,P16989,O75844 12 +Chaperone mediated autophagy 0.3223091649731007 0.1455576747496129 0.8842705826838975 1.0 0.9462593333091744 8 P10619 1 +Regulation of dna directed dna polymerase activity 0.3222811671087504 0.1454866064831754 0.8843266897193982 1.0 0.9462593333091744 8 Q9BRX5,P12004,P40937,P40938,Q9BRT9,P35249,P35250 7 +Aorta morphogenesis 0.2789006574155044 0.1444625264939112 0.8851352455322083 1.0 0.94631795851204 4 O95487 1 +Artery morphogenesis 0.2789006574155044 0.1444625264939112 0.8851352455322083 1.0 0.94631795851204 4 O95487 1 +Peptidyl threonine modification 0.26282397509653 0.144187465516084 0.8853524385850933 1.0 0.94631795851204 29 Q13557,Q10472,P78527,O95747,P05067,Q00535 6 +Microtubule organizing center organization 0.2548819354006453 0.1437201615865826 0.8857214498408001 1.0 0.94631795851204 37 O94927,Q15154,P43034,P53985,O14965,Q96CS2,Q9UHD1,Q9H6D7 8 +Fructose 1 6 bisphosphate metabolic process 0.3336646785950908 0.1424316972021931 0.8867390268583561 1.0 0.9466458908300976 6 Q9NQ88,P17858,Q01813,P04075,P09972 5 +Neural tube formation 0.2780469135333232 0.1423871207980432 0.8867742348499756 1.0 0.9466458908300976 18 P49815,P07737,P25440,Q9BYW2,O60313,O95487,P63167,Q92990,Q13308 9 +Positive regulation of dephosphorylation 0.2818758031060134 0.1413387627111053 0.8876023287451213 1.0 0.9468949985740168 16 Q13526,Q05655,Q86XL3,P63167 4 +Cardiac muscle tissue development 0.2662055228085725 0.1406155950222125 0.8881736276070344 1.0 0.9473454567998508 23 P09493 1 +Heart valve development 0.3320079522862793 0.1387196939538304 0.8896716550406136 1.0 0.9486249017678476 6 Q13464,P06400,Q9ULT8,P43243,P42345 5 +Negative regulation of cysteine type endopeptidase activity 0.2743945720501754 0.1379406938867879 0.8902872887340916 1.0 0.9488622914403004 19 P30044,Q15392,P78318,Q5JVF3 4 +Schwann cell differentiation 0.3189923417743457 0.1372532135964533 0.8908306504967751 1.0 0.9488701575529378 8 P31751,Q00535,P11047 3 +Regulation of telomerase activity 0.278767525493818 0.1368069312863443 0.8911834047870106 1.0 0.948963263666651 17 P22626,P27361,P17987,P50991,Q14103,P13010,P28482,Q9BUR4,Q15185 9 +Pallium development 0.2534131059721854 0.1356321663889303 0.8921120753185692 1.0 0.949542618577793 34 O14949,P50542,P61586,P62826,A0AVT1,Q96N66,Q00535 7 +Positive regulation of muscle cell apoptotic process 0.3183270424349163 0.135615430377081 0.8921253064770092 1.0 0.949542618577793 8 P98175 1 +Midbrain development 0.2661436278480699 0.1335743212940847 0.8937391908300159 1.0 0.9506206515906696 22 O14949,P00367,P12277,P63167,O15027,P14854,P61586,Q9Y5K5 8 +Pyrimidine nucleoside triphosphate biosynthetic process 0.3101927898729475 0.133407046344894 0.8938714730440953 1.0 0.9506206515906696 9 P04818,P17812,P27708 3 +Regulation of nucleobase containing compound transport 0.293319643978038 0.1333249702059548 0.893936380515644 1.0 0.9506206515906696 11 Q08J23,Q08211 2 +Positive regulation of dna biosynthetic process 0.2596532461007037 0.1320799377025114 0.8949210642709358 1.0 0.9512619908783392 28 P12004,P27361,P17987,P50991,P49368,Q99832,P13010,Q9BRT9,P28482,Q9BUR4,P35250,Q15185 12 +Regulation of viral process 0.249344651557871 0.1319110054351709 0.895054683621952 1.0 0.9512619908783392 44 Q13263,Q96SB4,Q16531,Q9UNP9,O75531,Q7Z434,Q08211,P11940,Q99816,P27105,Q9P035,Q15047,P19474,Q9UK61,Q14258,Q9Y6X9 16 +Serine family amino acid metabolic process 0.2816463071359893 0.1311282706704253 0.8956738374862481 1.0 0.9514490382054336 14 P34897,P34896,P32929,P23378 4 +Lipid import into cell 0.3004306061609929 0.1310152762388883 0.8957632228793759 1.0 0.9514490382054336 5 P33121,O95573,P07814,P31751 4 +Somite development 0.3009845917384595 0.130183340729082 0.8964213745813634 1.0 0.9516709966325616 10 Q7Z6E9,Q9H488,P78527 3 +Polysaccharide catabolic process 0.3215835757659666 0.1282098705386003 0.8979828889779953 1.0 0.9528512925449312 7 P35573,P62140 2 +Cellular polysaccharide catabolic process 0.3215835757659666 0.1282098705386003 0.8979828889779953 1.0 0.9528512925449312 7 P35573,P62140 2 +Morphogenesis of embryonic epithelium 0.2615829035871358 0.1275702046033048 0.8984891117147802 1.0 0.9529111954044958 24 P49815,P25440,Q9BYW2,P07737,O60313,O95487,P63167,Q9ULT8,Q92990,Q13308,O94788,O95747 12 +Blood vessel morphogenesis 0.2357259923815033 0.1261813589434206 0.8995883668249895 1.0 0.953758742208446 68 Q969H8,O95487,P61586,Q96PU8,P42785,P09601,Q9NZ08,P52789,P35579,Q9H488,Q9Y4G8 11 +Memory 0.3205476467401216 0.1258810473781142 0.8998260853244653 1.0 0.953851667498716 7 Q99538,Q96KQ7 2 +Potassium ion transport 0.2710063326534646 0.1247037015223987 0.9007581268883952 1.0 0.9544709384892134 19 P21333,P05023,P24941,Q92581,Q99996,O95747,O75351,Q9UHD1,Q96ER9 9 +Regulation of deoxyribonuclease activity 0.3253782775090528 0.1243700920328889 0.901022252565448 1.0 0.9544709384892134 6 P09429 1 +Mrna catabolic process 0.2291870514269122 0.124296945624897 0.9010801655870108 1.0 0.9544709384892134 109 Q9BRJ7,P27695,Q9Y333,P08670,P98175,Q5JVF3,Q9H2U1,Q8ND04,Q14103,Q969T7,P17844,Q09161,Q96DE0,Q92945,Q6PGP7,P16989 16 +Negative regulation of response to oxidative stress 0.297300002741312 0.1240050303870271 0.901311292135346 1.0 0.9544709384892134 5 P63244 1 +Negative regulation of response to reactive oxygen species 0.297300002741312 0.1240050303870271 0.901311292135346 1.0 0.9544709384892134 5 P63244 1 +Mitotic cell cycle 0.2152569441885637 0.1234191108317677 0.9017752245100824 1.0 0.9546503278546488 280 P43034,P11802,P42695,P50748,Q8TBC4,Q96DY7,P60953,Q07666,Q14141,O14965,Q99538,Q00535,Q69YH5,P21333,Q5JVF3,Q96KB5,P61586,Q13526,Q14807,P62753,P61289,Q01130,P62826,P35580,Q14166,Q8IY18,Q7Z7L1,P05067,Q9BTW9,Q08379,Q00839,P27695,P33991,O43663,Q9NPI1,P46013,Q14566,P78527,Q06481,Q86U86,P09884,Q9UH99,Q9Y5X1,O75844,Q9Y619,Q96QE3,Q86XL3,Q9P258,O43823,Q86XI2,P07437,P08243,O75531,P68371,P30260,Q9BUF5,Q96CW5,P55072,Q07864,P08183,Q86Y37,Q9UIG0,Q6IBW4 63 +Dicarboxylic acid catabolic process 0.3187414771820969 0.1218714930139137 0.9030007925848538 1.0 0.9557534399772448 7 Q9NRN7,Q8IYS1,P00367 3 +Positive regulation of telomerase activity 0.2786184663991867 0.1212954622538518 0.9034570140792332 1.0 0.9558731098683456 14 P27361,P17987,P50991,P13010,P28482,Q9BUR4,Q15185 7 +Anion homeostasis 0.2688741721854233 0.1203093425362016 0.9042381035964162 1.0 0.9564133910181616 4 P12277,P55011,O14745 3 +Cardiac muscle contraction 0.2734762985918855 0.1177356403922634 0.9062771262135794 1.0 0.9577186960830818 17 P21333,Q13557,P09493 3 +Regulation of body fluid levels 0.246748149244579 0.1163096315873151 0.9074071525190948 1.0 0.9583715289816164 44 P00403,P49257,P00813,P52789,P35579,Q13505 6 +Nephron morphogenesis 0.2933474032647041 0.1154523634280658 0.9080865763887986 1.0 0.9589255190800416 5 Q9BRK4,O95747 2 +Hair cell differentiation 0.2949568679495651 0.1143052913812587 0.9089957880786386 1.0 0.9594116952885796 10 O95487,O14745,Q9Y6M7,P43034,Q14160,P18074,Q14651,P19447,P35222 9 +Histone h3 k9 modification 0.2771333439698374 0.1135368561795998 0.9096049449719548 1.0 0.9598952399538012 12 Q03164,P26358,Q96KQ7 3 +Positive regulation of sister chromatid cohesion 0.2916548919239177 0.1118920204831553 0.9109090236040888 1.0 0.960792856625886 5 Q8IY18 1 +Nucleic acid phosphodiester bond hydrolysis 0.2285636267437021 0.1104452807923404 0.9120562438771378 1.0 0.9613647572277094 93 P27695,O95831,Q8IV08,O94919,Q9Y4W2,Q9UQ84,Q99598,Q14137,Q96DE0,Q5SY16,Q09161 11 +Regulation of organ growth 0.3073621069411949 0.1099794266809494 0.9124256910557164 1.0 0.9615947093931576 8 P49840,O00763,P16989 3 +Telomere maintenance in response to dna damage 0.2899443298619873 0.1083558338464929 0.913713434277304 1.0 0.9623136020325672 5 P27695 1 +Protein localization to chromosome 0.240918219182586 0.1060736312242499 0.9155239323259244 1.0 0.9637413239257332 48 Q9BYW2,P17987,Q99832,P50748,Q96DY7,O14773,P06493,Q9NYB0,Q8NEY8,P49368,Q9UFC0,Q8IY18,Q8WUX9,P50991,Q9UK61,Q9P258,O43684,P13010,P55072 19 +Single stranded viral rna replication via double stranded dna intermediate 0.3046404689742061 0.1040147057311304 0.9171576783877528 1.0 0.9645026809782524 8 Q9UK61,Q9Y6X9 2 +Negative regulation of telomere maintenance 0.2824723606640675 0.1033265530627645 0.9177038021075696 1.0 0.9647577516036574 11 P09874,Q00839 2 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.2520779317929743 0.1027116087285334 0.9181918599442004 1.0 0.9651112058550252 30 Q9H2U1,Q08211,Q14103,Q969T7,Q00839 5 +Regulation of intracellular estrogen receptor signaling pathway 0.2730184841753057 0.1023369741228764 0.9184892082482052 1.0 0.9652641216312158 13 P09874 1 +Dna dependent dna replication maintenance of fidelity 0.272997131848908 0.1017543199507641 0.9189516847736604 1.0 0.9653593666289412 12 P28340,P12004,P46100,Q9Y3Z3,Q07864,Q7Z7L1 6 +Regulation of phospholipid biosynthetic process 0.2862254901866416 0.1008834148584775 0.9196430089581876 1.0 0.9653593666289412 5 Q9UHD1 1 +Response to cytokine 0.2233529749526432 0.0983850015346158 0.9216265839380616 1.0 0.966962457495926 145 O60506,P31948,P43034,Q9NYF8,Q9Y5A7,P08670,P61586,P34896,P04818,O15382,P39023,Q14166,P19474,Q99943,P05067,Q00839,P32929,Q06481,O15111,O95429,Q6P2Q9,P49327,P23378,Q08211,P52789,O95747,Q96T37,Q92945,P84103,P16989 30 +Methylation 0.2271765795577448 0.096603269444475 0.9230414600001438 1.0 0.967807904942414 105 O96028,P26358,Q86X55,P62318,Q96KQ7,Q9NNW5,Q7Z2T5,O75530,P04818,Q08J23,Q14166,O60725,P09874,Q8NCA5,Q8N6R0,O75844,Q9Y2W6,Q96T37,Q99873,Q5T280,Q9BV86 21 +Platelet aggregation 0.2710164407428918 0.0962971988526972 0.9232845357413756 1.0 0.967862614996842 12 Q05655,P21333,P35579 3 +Negative regulation of transcription by rna polymerase i 0.257615894039727 0.0961540930241331 0.9233981902675976 1.0 0.967862614996842 4 O75367,P21333,Q9P0M6 3 +Positive regulation of nucleocytoplasmic transport 0.2537810258711323 0.0935728946493693 0.9254484420544232 1.0 0.969112432550334 24 P21333,Q05655,O00410,Q9C0E2,Q7Z434,P62826,Q08211,Q07666,P06493 9 +Positive regulation of protein import 0.2645809633159305 0.0935157706413025 0.925493821436424 1.0 0.969112432550334 18 Q05655,P21333,O00410,Q7Z434,P62826,P06493,O14737 7 +Protein modification by small protein conjugation or removal 0.2196915892860527 0.0929657738423365 0.925930751948946 1.0 0.969112432550334 187 P30536,P46777,P63244,P29144,Q86WB0,Q8TBC4,Q96DY7,P60953,Q9UHD1,Q9NT62,P49773,Q9UBW8,P55786,Q00535,Q9Y5A7,Q86UV5,Q8NEZ5,P61927,Q9C0C9,Q96JB5,Q9NR09,Q9Y4X5,Q13526,Q5T4S7,Q13867,O75832,P19474,O94966,Q9BT78,Q9BTE7,P63208,P34897,Q92990,Q7L5N1,Q9Y263,A0AVT1,Q99816,Q99497,Q9UBV2,Q7Z6E9,Q9NV06,Q15022,O75448,P30260,P26368,P31689,Q9UIQ6,Q8IWV8,P55072,Q15369,P49792,Q93009,Q9Y5K5,Q6DKJ4,Q96HY6 55 +Cerebellar cortex morphogenesis 0.3092633260704331 0.0928792075587878 0.925999524297713 1.0 0.969112432550334 6 Q06124,O15020,Q00535 3 +Negative regulation of plasma membrane bounded cell projection assembly 0.3046072257209112 0.0927334644304616 0.9261153107789064 1.0 0.969112432550334 7 Q05655,P50570,O94813,P35080,P47756,P27816 6 +G1 to g0 transition 0.3086916337134509 0.0918503677736726 0.9268169254662784 1.0 0.9696869758458708 6 O43159,O43175,Q9NNW5 3 +Somitogenesis 0.3038616767609035 0.0913068665796265 0.9272487620408656 1.0 0.9699791197386012 7 P78527 1 +Regulation of cilium assembly 0.2677371382853223 0.0904012453940855 0.9279683670656677 1.0 0.9704124615119092 15 P27695,Q9NVG8,Q9NT62 3 +Neuron migration 0.2527752323263789 0.089400452603828 0.9287636637873036 1.0 0.9709246458934376 24 P50542,Q9UPW6,P43034,Q00535,Q9Y4G8 5 +Muscle hypertrophy 0.2678393522422965 0.0887032602463321 0.9293177414501536 1.0 0.9713154470367992 14 P09874 1 +Response to ionizing radiation 0.2440252579081647 0.0878742391379167 0.9299766315711264 1.0 0.9715853718728046 33 P09874,Q6PJG6,O75844 3 +Regulation of cell cycle phase transition 0.2263831298417645 0.0878358505581479 0.930007143246404 1.0 0.9715853718728046 104 P27695,Q5JVF3,Q13769,Q9NPI1,P78527,P61289,Q06481,Q96DY7,Q08J23,O14965,Q9Y619,Q7Z7L1,P05067 13 +Protein localization to nucleolus 0.2762658721683401 0.0876267845268139 0.9301733130859268 1.0 0.9715992732907396 11 Q68CQ4,P62826 2 +Pigment granule localization 0.3060285747219826 0.0871373189379215 0.9305623619642662 1.0 0.9718459370103312 6 Q9Y4I1 1 +Positive regulation of ubiquitin dependent protein catabolic process 0.2510535787256193 0.0866686067511777 0.9309349306758908 1.0 0.9719156405019648 29 Q9C0D3,O43765,Q96JB5,Q9Y5A7,Q9Y4X5,P63244,P55072,P49840,O75832,O14965,Q8NEZ5,Q96HY6 12 +Regulation of telomere capping 0.3010542807176868 0.0860339831040026 0.9314394027573364 1.0 0.9721656473395964 7 Q93009,P28482,Q14103 3 +Regulation of protein localization to nucleolus 0.2782166430771934 0.0857901292137441 0.9316332532953872 1.0 0.9721656473395964 5 O95602,Q96D46 2 +Nls bearing protein import into nucleus 0.2892205638474242 0.0843818972555336 0.9327527998459008 1.0 0.9729318698356708 9 Q14974,Q7Z3B4,O00410,O00505,P52294,P49792,Q8NFH5,P52292 8 +Positive regulation of nuclease activity 0.2509933774834336 0.0834047897580464 0.9335296801078264 1.0 0.973345578537622 4 Q05655,P12004,P23396 3 +Organelle disassembly 0.2380633084388979 0.0824329530106589 0.934302432497665 1.0 0.9738317909077006 47 P30536,P49815,A6NDU8,P55072,P52789,Q709C8,Q99497,Q9NT62,Q08379,P21796 10 +Negative regulation of double strand break repair via homologous recombination 0.2759191785359492 0.0817109511137172 0.9348765697534758 1.0 0.9742704504595986 5 Q5UIP0,Q12888,Q6NSI4,A6NHR9 4 +Regulation of protein localization to chromosome telomeric region 0.2650282298239735 0.0802244849957456 0.9360587167103452 1.0 0.9751826263581304 13 O75367,O60832,P78371,Q9BVP2,P50990,P17987,Q9NVN8,Q99832,P49368,P50991,Q9BUR4,P48643 12 +Negative regulation of actin filament depolymerization 0.2613867523622979 0.0779643768212001 0.937856389885735 1.0 0.9765752316700084 17 P35612,P35611,O15020,Q9UEY8,O95425,Q13045 6 +Coenzyme a metabolic process 0.2854826423935847 0.0767173438370824 0.9388484068167706 1.0 0.977187149911198 9 Q9UKG9 1 +Positive regulation of dna binding transcription factor activity 0.2418930746791922 0.0766458609545079 0.9389052744662818 1.0 0.977187149911198 40 P60900,Q9Y6K9,P19474,P41440,P05067,P32929 6 +Positive regulation of atp dependent activity 0.2518069410019931 0.0758403945432859 0.9395460784520184 1.0 0.9772896741240786 22 P07737,P09493 2 +Regulation of small molecule metabolic process 0.2345178612293447 0.075487335826183 0.9398269733335998 1.0 0.9772896741240786 49 P09874,P00403,P62140,Q6P1A2,P34913,P55072,Q06481,P49840,P61964,P49792,P31751,Q99497,Q93009,Q9UBM7,P05067,O75844 16 +Regulation of cytokinesis 0.2493121019789733 0.0754077880137949 0.9398902629156072 1.0 0.9772896741240786 24 O43663,Q13526,P61586,O95425,O14965 5 +Positive regulation of developmental growth 0.2493006420303154 0.0753624511678065 0.9399263338452633 1.0 0.9772896741240786 24 Q7L576,P16989,P50542 3 +Activation of gtpase activity 0.2615201874131174 0.0748318468393043 0.940348502733986 1.0 0.9774088443789396 16 P84095,P31751,Q9P258 3 +Inner ear morphogenesis 0.2946635730858395 0.0746124774355267 0.9405230462399918 1.0 0.9774304254253414 7 O95487,O14745,Q14160,Q13308,Q14651,Q8IZL8 6 +Autophagosome maturation 0.2697509891911376 0.0722996280157563 0.942363460723928 1.0 0.9789595573618708 11 Q8WUX9,Q9H267,P55072,P13473,Q99570 5 +Pigmentation 0.2618283319776729 0.0721827124444201 0.9424565027528772 1.0 0.9789595573618708 14 Q9Y4I1,Q9H267,P63244,O14617 4 +Rna export from nucleus 0.2262756598761142 0.0717078570848607 0.9428344032128292 1.0 0.9789906391527856 54 Q5JVF3,Q13769,Q96MU7,Q08J23,Q5SRE5,P84103 6 +Thioester metabolic process 0.2408610133319577 0.0709515139825391 0.9434363444175108 1.0 0.9789906391527856 34 P09622,P50897,Q9UMR5,Q9HCL2 4 +Snrna processing 0.2590448805671119 0.0708815063436908 0.9434920621489188 1.0 0.9789906391527856 17 Q9NVR2 1 +Regulation of viral genome replication 0.2475094275002339 0.0707903538195108 0.9435646091016304 1.0 0.9789906391527856 29 Q13263,Q96SB4,Q9UNP9,O75531,Q7Z434,P11940,Q9P035,Q15047,Q9UK61,Q16531,Q9Y6X9 11 +Regulation of protein serine threonine kinase activity 0.233575726670679 0.0700920492427137 0.9441203949247 1.0 0.9792475897750312 49 P61586,P14174 2 +Protein localization to golgi apparatus 0.2873402078753406 0.0698134076073487 0.9443421754897164 1.0 0.979317811618965 8 O14976,Q9H4A6 2 +Response to interferon gamma 0.2486310203367046 0.0678658909528508 0.9458923912041832 1.0 0.9804455379148383 23 P19474 1 +Negative regulation of protein localization to nucleus 0.26672469731739 0.0664904560267783 0.9469873558834409 1.0 0.9811567992699596 5 Q9UHD1,Q9BRK4 2 +Cell death in response to oxidative stress 0.2498749141109746 0.0661574648934159 0.94725246064433 1.0 0.9811567992699596 21 Q05655,P09874,Q15233,P63244,Q99720,Q99497 6 +Spindle organization 0.2199272411708378 0.0660344210736119 0.9473504211956798 1.0 0.9811567992699596 78 Q00839,O94927,P21333,Q9BV86,P07437,O43663,P61586,Q96CW5,P62826,Q96CS2,O14965,P35579,Q9H6D7,Q9UH99,Q08379 15 +Synaptic vesicle membrane organization 0.2652061100798996 0.0641447239923324 0.9488549905511968 1.0 0.982247604752714 5 O14617 1 +Protein localization to nucleoplasm 0.2583001328021256 0.0641293171063495 0.9488672582098274 1.0 0.982247604752714 12 O60832,P78371,P50990,P17987,P50991,Q99832,P49368,P40227,Q9BUR4,P48643,Q4G0J3 11 +Negative regulation of protein serine threonine kinase activity 0.2559755240700814 0.0592485663678448 0.9527541271883204 1.0 0.9859500541206392 16 Q05655,O00410,Q96JB5,P31689,P10644,Q9UHD1,P04062 7 +Positive regulation of mitotic cell cycle 0.2372902888731327 0.0574645287938423 0.954175161318805 1.0 0.9867779572636388 42 P27695,P30260,Q96DY7,Q99538,P05067,Q9P258 6 +Synaptic vesicle localization 0.274792788791767 0.0565776430935868 0.9548816442382482 1.0 0.9873479308245168 9 Q00535,O14617 2 +Dna unwinding involved in dna replication 0.2552807840312815 0.0559609472655127 0.9553729179507902 1.0 0.9876952287728078 15 P33991,Q9BRT9,Q14566,P46063 4 +Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna 0.2489970287734791 0.0554997284986794 0.9557403462451102 1.0 0.9879143992086388 20 O60287,Q5SY16,O00541,Q14137 4 +Regulation of defense response to virus by host 0.2824826489096617 0.0550536857747112 0.956095693545784 1.0 0.988121012711708 7 O60828 1 +Regulation of protein depolymerization 0.2423410515367634 0.0532125601838684 0.9575625482152524 1.0 0.989359579760029 28 P35612,Q9UEY8,O15020,P35611,O95425,Q13045,O75083,Q66K74,Q9ULW0,P60981 10 +Inner ear receptor cell development 0.2773713450990655 0.0529901165849497 0.9577397824735432 1.0 0.989359579760029 8 O95487 1 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.2321192052980051 0.0528448293969415 0.957855542684833 1.0 0.989359579760029 4 O95373,O00410,O94992 3 +Regulation of ubiquitin dependent protein catabolic process 0.2219485281688902 0.0525726535438843 0.9580724061395498 1.0 0.989359579760029 56 P46777,P63244,O14965,P04062,O15294,Q9Y5A7,Q9UL15,Q8NEZ5,Q9C0D3,O43765,Q96JB5,Q96KB5,Q9Y4X5,P54725,O75832,P62913,P48729,O14980,P24941,Q92990,Q99497,Q9ULT8,P46379,P55072,P49840,O94874,Q93009,Q9Y5K5,Q96HY6 29 +Columnar cuboidal epithelial cell differentiation 0.2653232621376998 0.049596647620487 0.9604438181574708 1.0 0.991325253038143 10 P49327,P04818,P07437 3 +Positive regulation of blood vessel endothelial cell migration 0.2697312239462479 0.0479498152434259 0.961756238197678 1.0 0.9920603284396148 9 P09601 1 +Negative regulation of defense response to virus 0.2741002957437299 0.0479195925774365 0.9617803247081352 1.0 0.9920603284396148 8 Q15366,Q92890,O43657,Q86UT6 4 +Developmental growth 0.2219919990853342 0.0467555057567173 0.9627080914848408 1.0 0.9928561787242652 103 Q9BZH6,Q86XI2,P50542,Q9HCL2,P07602,Q7L576,O14965,Q9NZJ7,P05067,Q00535,P16989,O75844 12 +Cellular detoxification of aldehyde 0.252070221927804 0.0457881947149932 0.9634790681955524 1.0 0.9934900969258486 5 P10768,Q8TC12,Q99497,P11766 4 +Mrna cleavage 0.2627737226277416 0.0450572883246282 0.9640616458022871 1.0 0.9939295735148966 10 Q9UKF6,O43809,Q6UN15,Q12996,Q16630,Q9P2I0,P33240,Q09161,Q8N684 9 +Negative regulation of lipid biosynthetic process 0.2771580393347845 0.0442779526247771 0.9646828456920968 1.0 0.9941110359591157 6 Q8NF37,P05023 2 +Immunoglobulin production 0.2394241296829431 0.0442478123053044 0.9647068706412564 1.0 0.9941110359591157 26 O96028,Q9UQ84,P78527 3 +Erbb signaling pathway 0.2450411405060223 0.0432546928954785 0.9654985072258646 1.0 0.9946042969088486 20 P27695,O00443,Q9UNH7,Q99816,Q99538,P28482,Q06124,O75131 8 +Negative regulation of t cell proliferation 0.249604588595925 0.0427193328964028 0.9659252682140478 1.0 0.9948826778104826 5 P10644,Q92990 2 +Positive regulation of proteasomal ubiquitin dependent protein catabolic process 0.2380056276607673 0.0407036346331084 0.9675321639804736 1.0 0.996285460132048 27 Q9C0D3,O43765,Q9Y5A7,Q9Y4X5,P63244,P55072,P49840,O75832,O14965,Q8NEZ5,Q96HY6 11 +Protein localization to plasma membrane 0.223679727496656 0.0406176474511566 0.9676007151345394 1.0 0.996285460132048 67 O14976,Q9Y4I1,O15027,P63244,Q4V328,P84095,P31751,P41440,Q9H4A6,O95429,Q00535,Q9Y4G8 12 +Establishment of protein localization to plasma membrane 0.2419302553131773 0.0400417389584126 0.9680598500832672 1.0 0.9964353695755866 21 O15027,Q9H4A6,Q4V328,P63244 4 +Negative regulation of binding 0.2334944031634291 0.0393285132492246 0.968628473911151 1.0 0.9968592260652972 33 Q05655,Q13526,P63244,P09601,O14965,P10586,Q08379 7 +Cell cycle g2 m phase transition 0.2334952796091149 0.0371747216005292 0.9703456939171602 1.0 0.9977719193192808 41 O43823,O14965,P08183,Q9Y619,P05067 5 +Facultative heterochromatin assembly 0.2473005741819532 0.0370578552144178 0.9704388755957328 1.0 0.9977719193192808 16 Q9Y6X9,P26358 2 +Intracellular estrogen receptor signaling pathway 0.2458533185614042 0.037054232891466 0.9704417638076346 1.0 0.9977719193192808 18 P17844,P09874,Q86X55,Q92841 4 +Establishment of endothelial barrier 0.2474568273293588 0.0370348649205054 0.9704572066129318 1.0 0.9977719193192808 15 P49327,Q9Y4G8 2 +Retina development in camera type eye 0.2467358577747088 0.0357054365477499 0.9715172355796088 1.0 0.9987002344078916 16 P83731,P11047,Q9H0D6,P51532,Q9Y696,Q8NF37,P12268,P62873 8 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.2329788105989003 0.0347894345288372 0.9722476455576904 1.0 0.999242804481682 41 Q9C0D3,O43765,Q96JB5,Q9Y5A7,P46379,P63244,P55072,P53634,O75832,O14965,Q8NEZ5,Q96HY6 12 +Regulation of nuclease activity 0.2646986757785721 0.0345506156469607 0.97243808096882 1.0 0.999242804481682 8 P09429 1 +Cell cycle phase transition 0.2166423944037572 0.0341558407467199 0.9727528799557436 1.0 0.999242804481682 138 P27695,Q8IY18,O43823,Q5JVF3,Q13769,Q9NPI1,P78527,P61289,Q06481,Q96DY7,Q08J23,O14965,P08183,Q9Y619,P05067,Q00535 16 +Circadian rhythm 0.231969652270166 0.0341239778281096 0.9727782880752424 1.0 0.999242804481682 43 Q8WXF1,Q03164,Q9BWF3,Q7Z6Z7,P23246,Q15233,P04818,P78527,Q14103,Q9NRV9,Q93009,P06493,P43490,P62140,O15294,Q00839 16 +Regulation of histone h3 k9 methylation 0.2561849479627124 0.0340577489227716 0.9728311003984658 1.0 0.999242804481682 10 P26358 1 +Tetrahydrofolate metabolic process 0.2559149012544225 0.0336291506693223 0.973172876537386 1.0 0.9993245297795568 10 P34896,P04818 2 +Nucleoside monophosphate metabolic process 0.2327667386653268 0.0330972547708939 0.9735970319276146 1.0 0.9993835166233718 35 P00813,P04818,P55263,P32321 4 +Import into cell 0.2358118455386206 0.0301978096094922 0.9759092954146787 1.0 1.0 25 P05023,Q99816,P31751,Q99497,Q92581,P41440,Q15043 7 +Positive regulation of potassium ion transport 0.2631794880193738 0.0297778062929063 0.9762442589290532 1.0 1.0 7 Q99996,P21333 2 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.2260658023686968 0.0297753789207559 0.9762461948333948 1.0 1.0 49 P63244,O14965,P04062,O15294,Q9Y5A7,Q8NEZ5,Q9C0D3,O43765,Q96KB5,Q9Y4X5,O75832,P62913,P48729,O14980,P24941,Q92990,Q99497,Q9ULT8,P46379,P55072,P49840,Q93009,Q9Y5K5,Q96HY6 24 +Regulation of microtubule based process 0.2177976287158747 0.02504279918956 0.9800208254850696 1.0 1.0 57 P27695,P43034,Q9Y6A4,P61586,O14965,Q66K74,Q9UHD1,Q9BTW9,Q00839 9 +Multicellular organismal signaling 0.2367561899170648 0.0245431290941886 0.9804193820221184 1.0 1.0 21 P43034,P21333,Q13557,O75844 4 +Negative regulation of cell cycle process 0.221110719338182 0.0242275059245093 0.9806711380115058 1.0 1.0 68 Q5JVF3,Q13769,Q9NPI1,P78527,Q96DY7,Q08J23,Q9Y619 7 +Regulation of lymphocyte mediated immunity 0.2381573565779809 0.023526112551886 0.9812306094424784 1.0 1.0 20 O96028,P04439,P09429,Q96FZ2,Q96QE3 5 +Regulation of fatty acid metabolic process 0.2395372314700597 0.0231516422071876 0.9815293121839987 1.0 1.0 13 Q06481 1 +Cardiocyte differentiation 0.2393274868578193 0.0229726945282104 0.98167205380947 1.0 1.0 19 Q9H2U1,O75844 2 +Striated muscle contraction 0.2354030906449454 0.0206858598706983 0.983496248796354 1.0 1.0 21 P21333,Q13557,P09493 3 +Cell cell recognition 0.2381716353998288 0.0206601561323119 0.983516753030418 1.0 1.0 13 P45880,P49368 2 +Macroautophagy 0.2150890274056972 0.020516731951066 0.9836311647189682 1.0 1.0 87 P21796,P49815,A6NDU8,Q9Y6K9,O00267,Q96KQ7,Q8IYI6,Q9Y487,Q99570,P09601,Q709C8,O15269,P13473,Q9NT62,Q9NV70,Q00535,O15118,Q93050 18 +Microtubule nucleation 0.236850708421582 0.0183030509783545 0.9853970935463556 1.0 1.0 13 Q96CW5,Q9ULW0,Q99996,Q08379,Q9BSJ2 5 +Dna topological change 0.2511597084161651 0.0177227923491235 0.985859997837106 1.0 1.0 6 P11387,Q02880,P11388,P09429,P19447 5 +Positive regulation of immune response 0.220302131321447 0.0174065413617917 0.9861122906948 1.0 1.0 71 Q8WXF1,O96028,Q07666,Q12888,Q13144,Q9Y6K9,Q15233,P00813,P04439,Q05655,Q15046,Q7Z434,P78527,Q06481,Q99497,O60828,Q9NR50,Q9NUD5,Q96QE3,P23246,P46379,P49770,Q08211,P13010,P43243,P09429,Q96FZ2 27 +Response to tumor necrosis factor 0.2339321787031073 0.0163801921371293 0.9869310820151568 1.0 1.0 29 Q6P2Q9,P49327,Q08211,O15111,P16989,O95429,Q9Y5A7 7 +Carbohydrate metabolic process 0.2133955689386645 0.0163635993710885 0.9869443193528212 1.0 1.0 131 Q9NUJ1,Q14108,Q7LGA3,P30837,Q15185,P16278,Q6PJG6,Q9UBX3,P05067,Q15043,O75844 11 +Mitotic cell cycle process 0.2033369383684927 0.0163514398635522 0.9869540199382794 1.0 1.0 236 P42695,Q96DY7,Q14141,O14965,Q00535,Q5JVF3,P61586,Q13526,P61289,P35580,Q8IY18,Q7Z7L1,P05067,P27695,Q9NPI1,Q14566,P78527,Q06481,P09884,Q9UH99,O75844,Q86XL3,O43823,Q86XI2,O75531,P08183,Q9Y619 27 +Regulation of golgi organization 0.2471449148108447 0.0162485445437747 0.9870361076196206 1.0 1.0 9 Q9Y4I1,Q9P2W9,P28482,Q99996,P27361 5 +Cerebellar purkinje cell layer development 0.2482490184972696 0.0146932002024912 0.9882769442265078 1.0 1.0 7 O14949 1 +Protein ufmylation 0.2203673557417782 0.0145942774249434 0.9883558647211196 1.0 1.0 5 Q96JB5,Q96HY6 2 +Face development 0.2450345223228412 0.0138256548844515 0.988969074850388 1.0 1.0 9 O95470,Q06124,O94788,P28482 4 +Mitotic g2 m transition checkpoint 0.2315590855903267 0.0123794720921785 0.9901228626281438 1.0 1.0 12 Q9Y619,Q6NUQ1,Q96JB5,P06493 4 +Pattern recognition receptor signaling pathway 0.2327699458581567 0.012201469042297 0.9902648777867302 1.0 1.0 29 Q06481,Q5KU26,P41440 3 +Atp metabolic process 0.2178210215011439 0.0113694233760301 0.9909287080550484 1.0 1.0 103 P30536,P00846,P09874,P00403,P61586,P09622,P31930,P51970,P05067,Q9UDW1 10 +Cellular amino acid catabolic process 0.2274393218675719 0.0090591971274448 0.992771905346024 1.0 1.0 38 P09622,P11182 2 +Water soluble vitamin metabolic process 0.2337037997513602 0.0076307979718355 0.9939115631990671 1.0 1.0 18 Q9H2D1 1 +Vesicle mediated transport to the plasma membrane 0.2254744911592934 0.007281227624285 0.9941904722281912 1.0 1.0 44 Q8IYI6,O15027,P63244,Q4V328,Q96KP1,Q96L92,Q9H4A6,Q9NV70,Q9UMY4,Q9UBQ0 10 +Cellular aldehyde metabolic process 0.2302409293556848 0.006710720406548 0.9946456599834654 1.0 1.0 21 Q16775,O43488,P60174,Q04760,Q99497 5 +Protein demethylation 0.2370483811139906 0.0056781099673281 0.9954695480668738 1.0 1.0 7 Q9H6W3,Q8NB78,Q7LBC6 3 +Non motile cilium assembly 0.2312602229560532 0.0051104710124096 0.9959224518296046 1.0 1.0 11 P27695 1 +Positive regulation of mitotic nuclear division 0.2261256370838635 0.0043628048705024 0.9965189963949764 1.0 1.0 12 O14965 1 +Renal tubule development 0.2322180888436806 0.0023449756628906 0.9981289818378816 1.0 1.0 7 Q9BRK4,P35610,O95747 3 +Platelet activation 0.2267756350661534 0.001995037922484 0.9984081910993804 1.0 1.0 13 Q05655,P21333,P35579 3 +Protein k63 linked deubiquitination 0.2318244026049195 0.000575926920953 0.9995404768270242 1.0 1.0 9 P34897,P55072 2 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bc1879418cb05d8b1bb121bff964b17dd63528c4 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Acylglycerol transport", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aorta smooth muscle tissue morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cocaine", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system myelin maintenance", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Copulation", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Double strand break repair via synthesis dependent strand annealing", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain neuron fate commitment", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immature b cell differentiation", "Immune complex clearance", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Inositol trisphosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion import across plasma membrane", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of animal organ identity", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microtubule severing", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myd88 independent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fate commitment", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of atpase coupled calcium transmembrane transporter activity", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of hexokinase activity", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of interferon beta production", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of non canonical wnt signaling pathway", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of ribosome biogenesis", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron fate specification", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal signal transduction", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nitrogen utilization", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Opsonization", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast development", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine acyl chain remodeling", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor alpha signaling pathway", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic dna fragmentation", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of digestive system process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna catabolic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of opsonization", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to site of double strand break", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intestinal lipid absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of iron ion transmembrane transport", "Regulation of iron ion transport", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non canonical wnt signaling pathway", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of opsonization", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor activity", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of cardiac muscle", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to pheromone", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 3 uridylation", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of chemical stimulus", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory perception of taste", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal complex assembly", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tonic smooth muscle contraction", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Ureter morphogenesis", "Ureteric bud elongation", "Urogenital system development", "Uronic acid metabolic process", "Uterine smooth muscle contraction", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf57", "C12orf73", "C19orf70", "C1QBP", "C2CD5", "C2orf49", "C5orf51", "C9orf64", "CAB39", "CACUL1", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM129B", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPHN", "GPI", "GPR107", "GPR180", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTS2", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL42", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL58", "MRPL9", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS27", "MRPS28", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFR1L", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NEMF", "NENF", "NES", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PCYOX1L", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THADA", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM126A", "TMEM161A", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM70", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UACA", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13C", "VPS18", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASF2", "WASHC4", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WRAP53", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFYVE16", "ZMPSTE24", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF598", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWILCH", "ZYG11B", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB7", "ABCE1", "ABHD10", "ABHD12", "ACACA", "ACACB", "ACAD11", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL3", "ACTN4", "ACTR10", "ADA", "ADD1", "ADD2", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AGK", "AGL", "AGPAT1", "AGPS", "AHCYL1", "AIFM1", "AIP", "AKAP8", "AKAP9", "AKR7A2", "AKT2", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG11", "ALG12", "ALKBH5", "AMOT", "ANKLE2", "ANXA6", "AP1M1", "AP3D1", "AP3M1", "APEX1", "APLP2", "APOL2", "APOO", "APP", "APRT", "ARF5", "ARHGEF2", "ARIH1", "ARL6IP5", "ARPC1B", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPSCR1", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP2B1", "ATP2C1", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATRX", "AURKA", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAT2", "BCLAF1", "BIRC6", "BLMH", "BOLA2*", "BOP1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD7", "BRK1", "BSG", "BUB1B", "BUB3", "BUD31", "C12orf57", "C12orf73", "C5orf51", "CACUL1", "CAD", "CAMK2D", "CAMK2G", "CAPN5", "CAPZB", "CARM1", "CCDC115", "CCDC51", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC27", "CDC37", "CDC42", "CDC45", "CDCA2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CEP55", "CFAP20", "CGGBP1", "CHKA", "CHMP7", "CHORDC1", "CHRAC1", "CHUK", "CKAP2", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLIC4", "CLN5", "CLPTM1", "CLUH", "CNN3", "CNNM4", "CNOT7", "CNPY2", "COASY", "COG4", "COLEC12", "COMT", "COPS4", "COPS6", "COPS7A", "COX11", "COX2", "COX5A", "COX6B1", "COX7A2", "CPD", "CPNE3", "CPOX", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPVL", "CROT", "CRTAP", "CSK", "CSNK1A1", "CSTF2", "CSTF3", "CTBP2", "CTH", "CTNNB1", "CTPS1", "CTSA", "CTSC", "CUTA", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DBT", "DCAF13", "DCTD", "DCTN1", "DCTPP1", "DCUN1D5", "DDB1", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX5", "DHCR24", "DHCR7", "DHX29", "DHX33", "DHX36", "DHX9", "DIAPH2", "DIEXF", "DKC1", "DLD", "DNAJA1", "DNAJC7", "DNM2", "DNMBP", "DNMT1", "DOHH", "DOLPP1", "DPP9", "DPYSL2", "DSTN", "DUSP3", "DYM", "DYNC2H1", "DYNLL1", "EBP", "ECE1", "ECI1", "EDC3", "EED", "EHMT2", "EIF2B2", "EIF2B3", "EIF2B5", "ELOC", "ENDOD1", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERH", "ESD", "ESPL1", "EXO1", "EXOC1", "EXOC2", "EXOC6", "EXOC6B", "EXOC8", "EXOG", "EXOSC1", "EXOSC4", "EXOSC5", "EXOSC6", "FADS2", "FAM162A", "FAM208A", "FAM98A", "FAR1", "FASN", "FBXO22", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FIP1L1", "FKBP4", "FLII", "FLNA", "FLNC", "FLOT1", "FN3KRP", "FOXRED1", "FRYL", "FSCN1", "FUBP1", "G6PD", "GAA", "GAK", "GALNT1", "GAPDH", "GART", "GBA", "GCDH", "GCN1", "GGCX", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLUD1", "GLUL", "GNB1", "GNL1", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA2", "GOLPH3", "GPAM", "GPR107", "GRIPAP1", "GRWD1", "GSK3A", "GSR", "GSTM2", "GSTO1", "GTF3C2", "GTPBP1", "GUSB", "H2AFY", "H2AFY2", "HACD3", "HADH", "HADHA", "HAGH", "HAUS1", "HAUS4", "HAUS5", "HEBP1", "HECTD1", "HELZ", "HEXIM1", "HGS", "HINT1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMCES", "HMGB1", "HMGCL", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPD", "HNRNPM", "HNRNPU", "HOOK2", "HPRT1", "HS2ST1", "HSD17B12", "HSPA8", "HUWE1", "ICMT", "IDE", "IDI1", "IGBP1", "IGF2R", "IKBKG", "ILVBL", "IMPDH2", "INTS10", "IPO11", "IPO5", "IPO7", "IQGAP2", "ITCH", "ITGB1", "JUP", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "LAMC1", "LAMP2", "LARP7", "LARS", "LAS1L", "LBR", "LCLAT1", "LDAH", "LGMN", "LMAN1", "LMNA", "LNPEP", "LPCAT1", "LPCAT3", "LRP1", "LRWD1", "LSM2", "LSM7", "LSS", "LZTS2", "MACF1", "MANBA", "MANF", "MAP1S", "MAP2K2", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MATR3", "MAVS", "MBOAT7", "MCAT", "MCCC1", "MCM2", "MCM4", "MCM6", "MCMBP", "MDC1", "MECP2", "MED1", "MED24", "METAP2", "METTL13", "MGEA5", "MGST3", "MIF", "MIPEP", "MKI67", "MMS19", "MORC2", "MPRIP", "MPST", "MPV17L2", "MRC2", "MSH2", "MSMO1", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTHFD1L", "MTMR6", "MTOR", "MTX1", "MYCBP2", "MYDGF", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO5A", "NAA25", "NAGLU", "NAMPT", "NAP1L1", "NAPG", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCDN", "NCOR1", "NCSTN", "NDC1", "NDUFA11", "NDUFA8", "NDUFB9", "NDUFC2", "NDUFS7", "NEFM", "NEK9", "NENF", "NHP2", "NIPBL", "NLE1", "NLRX1", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOL9", "NONO", "NOP14", "NOP9", "NPC1", "NPC2", "NPEPPS", "NRDC", "NSD2", "NSRP1", "NSUN2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUCB2", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUP133", "NUP188", "NUP205", "NUP35", "NUP37", "NUP43", "NUP54", "NUP93", "NUTF2", "NXN", "OCRL", "OGFOD1", "OGT", "OPA1", "OPA3", "OSBPL6", "OTUB1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PACSIN2", "PAFAH1B1", "PAICS", "PARK7", "PARP1", "PBK", "PBRM1", "PCBP1", "PCBP2", "PCCB", "PCID2", "PCK2", "PCM1", "PCNA", "PCYOX1", "PDCD5", "PDCD6IP", "PDE6D", "PDLIM3", "PELP1", "PES1", "PEX5", "PFDN2", "PFKL", "PFKP", "PFN1", "PFN2", "PHF6", "PHGDH", "PI4KA", "PIK3C2A", "PIK3R4", "PIN1", "PITHD1", "PITRM1", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLS1", "PM20D2", "PMPCA", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2G", "POLR2L", "PON2", "PPAT", "PPHLN1", "PPIE", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R2A", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX4", "PRDX5", "PREP", "PRKAR1A", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRPF8", "PSAP", "PSMA1", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD10", "PSME3", "PSPC1", "PTBP2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUS1", "PXMP2", "QARS", "QKI", "RAB3GAP1", "RAB3GAP2", "RAC1", "RACK1", "RAD23A", "RAN", "RANBP2", "RAPGEF2", "RB1", "RBBP6", "RBM10", "RBM15", "RBM3", "RBM4", "RBMX", "RCC2", "RDH11", "RECQL", "RER1", "RETSAT", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RIF1", "RINT1", "RIOX1", "RNPS1", "ROCK1", "RPL10", "RPL11", "RPL13A", "RPL24", "RPL3", 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0.0133561195713928 +Endocytic vesicle membrane 12 39 3.121108448254528 0.0018017166969475 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 0.0022248923692317 0.023308813864781 0.0190345100678685 0.0003545199211167 +Vacuolar membrane 27 109 3.1199254520462745 0.0018089681494759 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 0.0058152150735298 1.8978941121453413e-05 0.0004893214848115 0.001945068631324 +Endosome 46 198 2.943959480910347 0.0032404242057102 49.68446601941748 210.85679611650485 0.3589512364806963 0.6263779709054735 15.417095902733692 27.960293924368397 1.2603534839168704 0.3964197633252465 0.1172475525147601 0.0138875699899977 0.0241161851748563 0.03412525209544 +Haus complex 2 5 2.730541884411304 0.0063230297887104 1.7142857142857142 4.192118226600985 0.9491182117305148 0.3338762298151981 1.141316695812668 1.4443833619809177 1.0587020246145291 0.3035334299176759 1.0 0.0743799864466655 0.0007018811705627 0.0053031795330487 +Endocytic vesicle 15 78 2.455414143300425 0.0140722363262393 19.521844660194176 83.27669902912622 0.428513908443532 0.5353120905813061 7.647069906220736 7.607555057832984 1.324058617895936 0.3761698531660883 0.0174923714516836 0.013686897100908 0.0254352042923354 0.0103384811371651 +Excitatory synapse 1 5 2.4181718910606778 0.0155987062107709 1.305825242718447 5.067961165048544 0.7953512276346466 0.4272224812891962 1.179791428227925 0.8869292057247719 0.8699509292644302 0.3159178070156055 0.0711332726649859 0.1349531130589082 0.0491545726752397 0.1630814235328921 +Tim23 mitochondrial import inner membrane translocase complex 1 6 2.386233488633545 0.0170219400465798 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0012601973854463 0.0047533286028597 0.0274146616230463 0.0968157430558884 +Mitotic spindle microtubule 3 7 2.2870811658858377 0.0221910859886587 2.0825242718446604 6.441747572815534 0.5708907058485942 0.4767644436015336 1.3027176362136732 1.6381391450699827 0.8609171719873856 0.3046846082742396 1.0 0.1180585699575878 0.003279014583115 0.0027630263410089 +Golgi apparatus 49 280 2.263098201900996 0.0236296363803842 79.29126213592232 307.80825242718447 1.0941692666231844 0.5225509759640199 24.90716006851961 39.34912971804267 1.7376904428153446 0.4394682295132952 0.3769257803639871 0.0588927004875962 0.0275561652335904 0.1004696766315935 +Endosome membrane 21 115 2.247193152772092 0.0246276855979907 28.436893203883496 125.75485436893204 0.1968108610887141 0.5657595498250074 10.058247741499075 16.477863960688197 1.2734596099850304 0.3756178998455078 0.2882676887574082 0.0303963465448423 0.0767758336046659 0.078593950334285 +Late endosome 12 55 2.2403794240567696 0.0250663009258351 15.655339805825244 65.18203883495146 0.1482522199608934 0.3683478922291265 6.675389202214119 9.543379127098556 1.7080817701484334 0.368772234437858 0.266182518567592 0.1347944849764237 0.0591197200397109 0.0738177159624069 +Dihydrolipoyl dehydrogenase complex 1 5 2.22411549886918 0.0261406743773631 2.3810679611650487 4.720873786407767 -0.5950550176261864 0.4614692602206815 1.4690763313136388 1.0035138330866908 1.000113717535392 0.3241162856662877 1.0 0.0031504918831051 0.018519525655472 0.0675218785318175 +External side of plasma membrane 6 18 2.2008766548890657 0.0277447570246505 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.4077336964203657 0.271213554068588 0.2507795031056615 0.2554949002325081 +Dna polymerase complex 5 10 2.1444768191694137 0.0319947008662926 4.252427184466019 11.6626213592233 -0.0029591580698458 0.5862527263353327 2.732289649750698 2.062202828801425 0.8514756592756991 0.2950821613853165 0.0937235599037543 0.1758008751515455 0.082298412398385 0.00223229240551 +Ciliary basal body 5 16 2.1115349004430013 0.0347263613862733 5.252427184466019 18.766990291262136 0.3291521736423572 0.5817838581641566 2.9698107115056382 4.463887207345828 0.8023105632951456 0.3105252801373722 1.0 0.6883336871670287 0.7882229027893156 0.6989088546616515 +Early endosome 18 90 2.023975757943954 0.0429726461117494 24.66504854368932 96.93203883495146 0.530758374709677 0.5743319290889299 8.086272783051246 14.025470683081796 1.1449007118883376 0.3721207721610414 0.4044123990598698 0.2869551331057779 0.0186282906338651 0.0337421119325823 +Golgi associated vesicle 7 31 2.0034080685106885 0.045133506137398 6.745145631067961 30.33009708737864 0.696501539533066 0.3869218626415568 3.3093865809086713 3.3403631844705557 1.2881306559419168 0.3350067162782171 0.2849410889163232 0.0040840095186766 0.0235082740557435 0.005344696455789 +Intrinsic component of plasma membrane 16 69 1.965602251328298 0.0493445738518529 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.9046312933555888 0.4683211830617984 0.5713477614629714 0.7528954879179477 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..207d3f4a769858ec1e70ed40876cc61b200d4b39 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 899, + "title": "Average number of proteins per term", + "value": 27.696329254727473 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7708deded6ba6e49ea6402c645d3339a37c2df08 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0e78a3b5701c2d7cfb028f6d815459781d3ba518 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,303 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuole 0.404422814488064 3.9537352826917807 7.694053158036063e-05 0.0668340240037439 0.0026119681763835 201 P15586,Q8WTV0,Q8NHP8,Q14108,Q14849,Q8NCC3,P42785,O43681,O95298,Q9UHG3,Q92542,Q15043,Q93050,P55735,P49815,Q9Y4I1,P00813,Q15165,P07602,P09622,P19474,P41440,O15118,P27695,Q8N511,Q9BZH6,Q99523,P42892,P50897,O15260,P10619,P61916,Q8IV08,Q9HC07,Q9UIQ6,Q9UMR5,P16278,P53634 38 +Nuclear outer membrane endoplasmic reticulum membrane network 0.3751400809463499 3.9490980770848743 7.844620774455358e-05 0.0680964036539464 0.0026119681763835 276 P10321,Q9BZF3,Q6P1A2,Q8TB61,Q9BUR5,Q14108,Q14849,P24390,Q15125,P07099,Q9Y282,P09601,O15269,P43307,P55735,Q13555,Q9BQE5,Q2TAA5,P61586,Q15392,Q10472,P57088,Q9HD20,Q15800,P30519,O60725,Q86YN1,Q9BV10,P48449,Q8N511,P04439,O95197,O43865,Q99523,Q16850,Q99720,Q9NZ08,O15260,Q6NUM9,Q96N66,O43852,Q9Y3B3,Q9NZ01,O75844,O14880,O14735,Q86XL3,Q8IV08,Q13557,P49257,Q6UWP7,Q14739 52 +Endoplasmic reticulum 0.3413014176636472 3.860543960029449 0.0001131348836822 0.096712157806928 0.0032179215458909 435 P30536,Q9UQB8,Q9BZF3,Q9UMX5,Q14108,P24390,P07099,P55735,Q9H6V9,Q13555,Q9BQE5,P61586,Q15392,Q9HD20,P30519,O60725,P05067,O15118,P48449,Q8N511,O43865,Q99523,Q16850,Q99720,Q9NZ08,O15260,P10619,P61916,O75844,Q8IV08,P46776,P80303,Q14739,Q9Y2B0,Q6P1A2,Q9Y282,P09601,O43681,Q92542,Q9Y4I1,Q14257,Q15800,Q9BV10,P27695,O43493,Q06481,Q6NUM9,O43852,O14880,Q86XL3,P49257,P53634,Q6UWP7,P10321,Q8TB61,Q9BUR5,Q14849,Q15125,Q99797,O15269,P43307,Q9UHD1,Q2TAA5,Q10472,P57088,Q86YN1,P04439,O95197,O43390,Q96N66,Q9Y3B3,Q9NZ01,Q969H8,Q13557,P52789,O75503,O14735 77 +Triglyceride rich plasma lipoprotein particle 0.9126406353408364 3.8575222453635742 0.0001145422574733 0.0978544310783956 0.0032179215458909 2 Q9UHG3 1 +Organelle subcompartment 0.3514476636273774 3.7296174431803686 0.0001917707069258 0.1583730359287675 0.0041048063220565 336 P10321,Q9BZF3,Q6P1A2,P11717,Q8TB61,Q9BUR5,Q14108,Q14849,Q96NT0,P24390,Q15125,P07099,Q9Y282,P09601,Q8NBN3,O15269,P43307,P67812,P55735,Q13555,Q6XZF7,Q9BQE5,Q2TAA5,P61586,Q15392,Q10472,P57088,Q9HD20,Q15800,P84095,P30519,O60725,Q86YN1,Q96ED9,Q99943,P05067,Q9BV10,P48449,Q8N511,P04439,O43493,O43865,Q9BZH6,O95197,O95864,Q99523,Q16850,O15027,Q99720,Q9NZ08,O15260,O00461,Q6NUM9,Q96N66,O43852,Q9Y3B3,Q9NZ01,Q9Y5X1,O75844,O14880,O14735,Q86XL3,Q8IV08,Q9HC07,P49257,Q13557,Q01968,O95487,Q06136,Q6UXD5,Q6UWP7,Q14739,P49458,Q9H4A6,Q9H9E3,Q10713 76 +Calcium and calmodulin dependent protein kinase complex 0.8825281270681699 3.715774770667619 0.0002025819808015 0.1665150642743943 0.0041391181986506 2 Q13555 1 +Mitochondrial alpha ketoglutarate dehydrogenase complex 0.965829645370299 3.6853803706512775 0.0002283613284461 0.1856135560519315 0.004462974658111 3 P09622 1 +Mitochondrial intermembrane space protein transporter complex 0.952002648129758 3.6249429648034504 0.000289025230723 0.228849126355344 0.0055283762217026 3 Q9Y5L4,Q9Y5J9 2 +Tim22 mitochondrial import inner membrane insertion complex 0.809728656518866 3.362195531868349 0.0007732534763118 0.5011370046252434 0.0115859145867392 2 Q9Y584 1 +Vesicle membrane 0.3495105908306273 3.3193499173275587 0.0009022729069985 0.5558129404530913 0.012875291164947 235 P10321,Q9BZF3,P11717,Q8WTV0,Q14108,Q14849,P24390,P42785,O95298,Q9NZJ7,Q92542,Q15043,Q93050,P55735,Q13555,P61586,Q5KU26,P07602,P30519,O15118,Q8N511,Q99805,O43493,P04439,O43924,Q96T51,Q99523,Q9Y487,P42892,Q9BZE9,Q06481,O15260,Q4V328,O00461,P13473,Q9Y3B3,Q9UH99,Q8IV08,Q9HC07,P49257,Q9UIQ6 41 +Proton transporting v type atpase v0 domain 0.8687238203269838 3.250840375229861 0.0011506444146609 0.6447824697360685 0.0149917294026115 3 Q93050 1 +Vacuolar proton transporting v type atpase v0 domain 0.8687238203269838 3.250840375229861 0.0011506444146609 0.6447824697360685 0.0149917294026115 3 Q93050 1 +Pericentriolar material 0.7842488418266073 3.234583837903512 0.0012182014980655 0.6657381976565729 0.0155947915920666 2 Q15154 1 +Endocytic vesicle membrane 0.6004191582884909 3.121108448254528 0.0018017166969475 0.8023394720174684 0.0193602662664152 39 P04439,P10321,P11717,Q13555,O43493,Q8WTV0,Q14108,Q5KU26,Q9Y487,Q06481,P13473,Q93050 12 +Vacuolar membrane 0.4312189324727792 3.1199254520462745 0.0018089681494759 0.803626156390626 0.0193602662664152 109 Q8WTV0,Q99747,Q14108,Q14849,Q96NT0,P42785,O95298,Q9NZJ7,Q92542,Q15043,Q93050,P55735,P07602,P41440,O15118,Q8N511,Q9BZH6,Q99523,Q9Y487,P42892,O15260,P10619,P13473,Q8IV08,Q9HC07,Q9UIQ6,O75503 27 +Axon hillock 0.7597617471872975 3.1099544552775416 0.0018711619345326 0.8143236836029254 0.0197902891664098 2 O14965 1 +Phosphatidylinositol 3 kinase complex 0.755459960291201 3.087854074564032 0.0020160744203656 0.8370448682138287 0.0203175167695672 2 Q99570 1 +Golgi lumen 0.9084615602600016 3.066008862297767 0.0021693688474095 0.85806429103636 0.0214143552448208 4 P05067 1 +Lsm1 7 pat1 complex 0.8263292113389712 3.053363225446602 0.0022629185186406 0.8695374447555732 0.0214143552448208 3 P62310 1 +Intrinsic component of vacuolar membrane 0.8203333513274562 3.0250313286673145 0.0024860737429284 0.893303088942989 0.0228059213764556 3 O15118 1 +Myosin filament 0.8137127210568673 2.993628975223897 0.0027568096281123 0.9164069040742154 0.0238365117762917 3 P35580 1 +Elongin complex 0.8065648414797595 2.959585522779789 0.0030805318492712 0.9375677008282024 0.0257575133082366 3 Q15369 1 +Endosome 0.3565632612477162 2.943959480910347 0.0032404242057102 0.9459513919914688 0.0267260675315001 198 P10321,Q9BZF3,P11717,Q14108,Q14849,Q96NT0,Q99538,Q9NZJ7,Q92542,Q15043,Q93050,Q5VW38,Q9Y4I1,P61586,P62826,P07602,P41440,P05067,O15118,P27695,P04439,Q99805,O43493,Q05655,Q8IYI6,Q99523,Q96T51,Q9Y487,P42892,O14617,Q06481,Q4V328,O00461,P31751,P13473,Q99570,Q9UH99,Q9Y4G8,Q9P258,Q8IV08,Q9HC07,Q01968,Q9UIQ6,P09429,Q96L92,Q9H4A6 46 +Cuticular plate 0.7246856386499048 2.927911944862389 0.0034124667419521 0.9537203960976076 0.0276379063154504 2 Q9Y5X1 1 +Atac complex 0.7971818710258609 2.914674068399128 0.0035606018382816 0.9595097196721012 0.0280787811632913 3 Q9NRF9 1 +Mhc protein complex 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9668219012723172 0.0290548877746885 3 P10321 1 +Mhc class i protein complex 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9668219012723172 0.0290548877746885 3 P10321 1 +Filopodium membrane 0.7088021178027841 2.844073579022169 0.0044540760912097 0.9819237889570758 0.0320337152479804 2 Q8WXH0 1 +Ikappab kinase complex 0.7776563069476173 2.820394676892348 0.0047964616005726 0.9867319101044442 0.0332669056851825 3 Q9Y6K9 1 +Equatorial microtubule organizing center 0.7041694242223742 2.8194525160082575 0.0048105647820619 0.9868998728047816 0.0332669056851825 2 Q96CW5 1 +Risc loading complex 0.765262806268616 2.7599701136432544 0.0057806649508453 0.9945486743423096 0.0379329765752555 3 O75569 1 +Myosin ii complex 0.8355208957678723 2.7438828182953787 0.0060717207560245 0.995810255467059 0.0394081470091584 4 P35580,P60660 2 +Haus complex 0.9002386004646687 2.730541884411304 0.0063230297887104 0.9966622262089152 0.0405834729932755 5 Q9H6D7,O94927 2 +Endosome lumen 0.8193729319693398 2.6707929577666123 0.0075672306124836 0.9989178555702548 0.0447561863198868 4 Q9UIQ6,P05067 2 +Cul4a ring e3 ubiquitin ligase complex 0.6737260092653928 2.6557357530759456 0.0079135597416735 0.9992092979091204 0.0455128081644145 2 Q92990 1 +Epsilon dna polymerase complex 0.796655777666622 2.566849521996113 0.0102627137796278 0.9999061533914904 0.054831316975629 4 Q9NRF9,Q9NRG0 2 +Esc e z complex 0.7794229311953839 2.487117859959931 0.0128782726308089 0.9999913050044362 0.0632653939622802 4 O75530 1 +Gamma tubulin complex 0.7044025157232784 2.4565219520295547 0.0140289230757399 0.9999969528518684 0.0672922364749423 3 Q96CW5,P38398 2 +Endocytic vesicle 0.4082671123242469 2.455414143300425 0.0140722363262393 0.9999970708490722 0.0672922364749423 78 P04439,O43493,P08670,Q13555,P10321,Q8WTV0,P11717,Q14108,Q5KU26,Q9Y487,Q06481,O00461,P13473,Q9Y4G8,Q93050 15 +Saga complex 0.6340172071475909 2.437079389812878 0.0148064282498636 0.9999985006916844 0.0694531108876557 2 Q9Y6J9 1 +Excitatory synapse 0.8273435516735645 2.4181718910606778 0.0155987062107709 0.9999992725786184 0.0715471269565464 5 Q9UQB8 1 +Tim23 mitochondrial import inner membrane translocase complex 0.8835924830252165 2.3862334886335455 0.0170219400465798 0.9999998018937288 0.0761329557307228 6 Q99595 1 +Lateral element 0.6154864328259504 2.333025795305757 0.0196467915013223 0.9999999820966416 0.0845094045918122 2 P38398 1 +Presynaptic cytoskeleton 0.6101919258769101 2.303059532403109 0.0212754937771986 0.9999999959843489 0.0902201363476488 2 Q8IUD2 1 +Postsynaptic cytoskeleton 0.6101919258769103 2.303059532403109 0.0212754937771986 0.9999999959843489 0.0902201363476488 2 O15020 1 +Mitotic spindle microtubule 0.8330419733203882 2.2870811658858377 0.0221910859886587 0.9999999982688332 0.0927897037386241 7 Q9H6D7,O94927,Q96CS2 3 +Golgi apparatus 0.3042399792449941 2.2630982019009953 0.0236296363803842 0.9999999995391972 0.0961223669953189 280 Q9UQB8,O14976,P10321,P11717,Q8TB61,Q9BUR5,Q14108,P24390,Q9Y282,Q7RTS9,Q9UHD1,Q92542,Q93050,P49815,P25398,Q6XZF7,Q5VW38,Q7LGA3,Q15392,Q10472,Q96ED9,P05067,O15118,Q92896,P04439,Q99805,O43493,O95197,Q9BZH6,Q99523,Q99598,P50897,O15260,O00461,O43852,Q9Y3B3,Q969H8,Q8IV08,Q9HC07,O43823,L0R6Q1,P49257,P50542,Q14CX7,P80303,P53634,P16278,O75503,Q10713 49 +Endosome membrane 0.3657878298654423 2.2471931527720916 0.0246276855979907 0.9999999998162568 0.0979658820911226 115 P10321,Q9BZF3,P11717,Q14108,Q14849,Q92542,Q15043,Q93050,O15118,P04439,Q99805,Q96T51,Q99523,Q9Y487,P42892,Q06481,Q4V328,O00461,Q9UH99,Q8IV08,Q9HC07 21 +Late endosome 0.4313521093768037 2.2403794240567696 0.0250663009258351 0.9999999998773694 0.0992713856049595 55 Q8IV08,Q9HC07,P11717,Q9Y4I1,Q8IYI6,Q14849,Q14108,P07602,O15118,Q9Y4G8,Q9NZJ7,Q15043 12 +Glycogen granule 0.6607083747103549 2.2316393049700634 0.0256388116875401 0.99999999992768 0.1006519288519588 3 P49327,P62140 2 +Dihydrolipoyl dehydrogenase complex 0.7833894485587644 2.22411549886918 0.0261406743773631 0.9999999999544898 0.1021759402836932 5 P09622 1 +External side of plasma membrane 0.6127705562467192 2.2008766548890657 0.0277447570246505 0.9999999999896608 0.1061384534687694 18 O96005,P00813,P42892,P08183,P41440,P00390 6 +Striated muscle thin filament 0.7134804463607052 2.174927563465051 0.0296355450093603 0.9999999999982032 0.1110098123475624 4 P09493,P67936 2 +Myofilament 0.7134804463607052 2.174927563465051 0.0296355450093603 0.9999999999982032 0.1110098123475624 4 P09493,P67936 2 +Dna polymerase complex 0.7188657506625014 2.1444768191694137 0.0319947008662926 0.9999999999997986 0.1188563474330458 10 P28340,Q9NRG0,Q9NR33,P09884,Q9NRF9 5 +Ciliary basal body 0.6185267468205594 2.1115349004430013 0.0347263613862733 0.999999999999984 0.125883060025241 16 O43805,Q9BZH6,Q9Y6A4,Q13526,A0AVF1 5 +Chloride channel complex 0.6338960609069825 2.09072944719075 0.0365523237233356 0.9999999999999972 0.1309184821803933 3 O00299,Q96S66 2 +Centriolar subdistal appendage 0.5688285903375336 2.0653468737010603 0.0388901914297052 0.9999999999999996 0.1365714144347853 2 Q14203 1 +Early endosome 0.3709024460131376 2.023975757943954 0.0429726461117494 1.0 0.1468912884200104 90 P27695,P04439,Q8IV08,Q9HC07,Q9BZF3,P10321,Q5VW38,Q9Y4I1,Q99523,P11717,Q96T51,Q9UIQ6,Q06481,Q92542,Q4V328,P41440,P05067,Q15043 18 +Golgi associated vesicle 0.4916665651411594 2.0034080685106885 0.045133506137398 1.0 0.1519663745974565 31 Q8N511,O43493,P11717,Q99523,P24390,Q9Y3B3,P05067 7 +Intrinsic component of plasma membrane 0.3945629519658431 1.965602251328298 0.0493445738518529 1.0 0.1619006273460431 69 P04439,Q99805,P10321,P11717,O96005,Q8WTV0,O60637,Q9UIQ6,Q99797,P05067,P41440,O15118,Q9Y4G8,Q92542,P10586,Q15043 16 +Saga type complex 0.7219330195222123 1.9456564918768589 0.0516960162068964 1.0 0.1683866614855069 5 Q9NRF9 1 +Pronucleus 0.6635266484767495 1.9310332413860865 0.0534789417233834 1.0 0.1723210344420132 4 O43823 1 +Copi coated vesicle membrane 0.6188185321466753 1.916932289027418 0.0552465343593875 1.0 0.1755004748731074 12 P24390 1 +Nsl complex 0.5984234254033957 1.9009924231114557 0.0573030050620761 1.0 0.181392258981713 3 P61964 1 +Nuclear pore outer ring 0.6933157001664693 1.8853443937614112 0.0593833561851675 1.0 0.1856250938713792 9 P55735,Q8NFH4 2 +Lysosomal lumen 0.4615864286754399 1.8566796510894488 0.0633567442624942 1.0 0.1950606612739121 35 P15586,Q8IV08,Q8NHP8,Q14108,P07602,O43681,P10619,Q9UMR5,P16278,P61916 10 +Cytosolic region 0.7345089064476302 1.8525211413412164 0.063951024593539 1.0 0.1962183314320533 7 Q9UQB8 1 +Dendritic shaft 0.6974464137191719 1.83249237245747 0.0668780971157769 1.0 0.2038081671426559 5 Q9UQB8 1 +Coated vesicle 0.3530799203029441 1.818835809080548 0.0689364834241366 1.0 0.207966102678855 83 P10321,P11717,Q14108,Q96NT0,P24390,Q9Y282,P55735,Q5VW38,P05067,Q8N511,P04439,O43493,O15027,Q99523,P42892,Q9Y3B3,Q9Y5X1,Q01968,P49257,P53634 20 +Copi coated vesicle 0.5832543851949308 1.7975972041601638 0.0722408617310303 1.0 0.2161329038219712 14 Q9Y3B3,Q8N511,P24390 3 +Iswi type complex 0.6491440439383114 1.79050887702156 0.0733721414673584 1.0 0.2178976766306069 10 Q9NRF9,Q9UIG0,Q9NRG0 3 +Microtubule bundle 0.5181998676373362 1.766013617304802 0.077393564338297 1.0 0.2261752825434704 2 Q7KZI7 1 +Postsynaptic cytosol 0.7370913395792074 1.7654491694477203 0.0774883059214559 1.0 0.2261752825434704 6 Q9UQB8 1 +Endoribonuclease complex 0.5669799693604858 1.7464432735012252 0.0807339560587636 1.0 0.2328623716031342 15 Q9Y4W2,O75569,Q5KU26,Q99598,Q8N5L8 5 +Exocyst 0.6810283046781459 1.7107361411900008 0.08712983274921 1.0 0.2463198730866032 8 Q8IYI6,Q96KP1,Q8TAG9,Q9NV70 4 +Ruffle 0.3822854761881018 1.6958106420498775 0.0899217464424864 1.0 0.2498293868544691 56 Q9UQB8,P63167,Q9Y4I1,P61586,Q06481,Q7L576,P31751,P35579,Q10713,P09493,Q9Y5X1 11 +Cul2 ring ubiquitin ligase complex 0.6670167264765771 1.6902530728251492 0.0909795487244926 1.0 0.2508914549181561 5 Q15369,Q9C0D3 2 +Cell surface 0.3679051990362803 1.6866634173961452 0.0916680901708837 1.0 0.2512488203159282 73 P04439,O96005,P10321,P14174,O15484,P11717,Q8WTV0,Q99523,P00813,P42892,P09429,P08183,P41440,P05067,Q00839 15 +Transcription factor tfiih holo complex 0.5576306762978744 1.6784576927492345 0.093257783005819 1.0 0.2548290180007029 3 Q96T76 1 +Lipid droplet 0.4489487913900957 1.648387166947555 0.0992732477386435 1.0 0.2664079096031061 31 P48449,Q9H6V9,Q8NBX0 3 +Proteasome core complex beta subunit complex 0.6884998575643131 1.643357604507186 0.1003089663371263 1.0 0.2675897944720374 7 P28074,P49721 2 +Phagocytic vesicle membrane 0.4907574827422672 1.6323388803256114 0.1026081169372932 1.0 0.2713079327253723 22 P04439,P10321,Q9Y487,Q06481,P13473,Q99570,Q93050 7 +Proteasome core complex 0.5504489045370501 1.601442293518507 0.109278991606097 1.0 0.2831176180227124 14 P60900,P28074,P49721 3 +Endoplasmic reticulum golgi intermediate compartment membrane 0.479751581791525 1.5968740105624717 0.1102937941113098 1.0 0.2841092289572135 23 Q8N511,P49257,Q10472,Q9BZE9,P24390,Q9Y282,O15260,P53634 8 +Gap junction 0.594179390244113 1.5828410145536955 0.113457705808933 1.0 0.2897684020517919 4 Q69YQ0 1 +Neuron projection terminus 0.5372705409563648 1.564469873650675 0.1177072625626936 1.0 0.2955833213515685 15 Q9UQB8,Q14141 2 +Sarcoplasm 0.5366284757496648 1.5605137336630956 0.1186385270694789 1.0 0.2962667662096155 15 Q13557,Q13555,P55145,P35573,P52789,O43852 6 +Neuron spine 0.4445828882943246 1.5554706789925543 0.1198340124586305 1.0 0.2983062719235679 30 Q9UQB8,Q7L576,P61586,P05067 4 +Cilium 0.3332458729517417 1.554274820359289 0.1201188770148293 1.0 0.2983062719235679 81 A6NIH7,P63167,P43034,Q14141,O14965,Q15388,Q15154,Q13526,P62826,P09622,Q92973,P05067,O43805,Q9BZH6,O43924,Q9Y6A4,Q99570,Q01968,A0AVF1,Q10713 20 +Clathrin coated endocytic vesicle membrane 0.5546754568863554 1.5494378730619562 0.1212764953762151 1.0 0.3003514306975685 12 Q14108,O43493 2 +Mitochondrial tricarboxylic acid cycle enzyme complex 0.6446282930397056 1.5367540676806437 0.1243535453321609 1.0 0.3071259265209139 8 P09622 1 +Late endosome membrane 0.4487149923410579 1.5244352736083244 0.1274000142375313 1.0 0.312077964031446 27 Q8IV08,Q9HC07,Q14849,Q14108,Q15043,O15118 6 +Transport vesicle 0.3341747320661287 1.5043825884115312 0.1324828848453552 1.0 0.3210299554608472 89 P55735,P27695,P04439,O43493,P49257,P10321,P11717,Q99523,P24390,P50897,O15260,Q92542,O00461,Q14141,Q9UHD1,P05067 16 +Vacuolar lumen 0.3588488069511262 1.4874257502181003 0.1369024001017331 1.0 0.3255959198186722 66 P15586,Q8NHP8,Q14108,O43681,Q99538,Q9NZJ7,P06280,P15289,P07602,Q05655,P08236,P50897,P10619,P13473,Q99536,P61916,Q8IV08,P68371,P07437,O00462,P55072,Q9UMR5,P53634,P16278 24 +Caveola 0.5275272527290328 1.4629181297612115 0.1434897825020247 1.0 0.3372306323842076 14 Q8WTV0,P09601 2 +Filopodium 0.4333052295405272 1.461943498281291 0.1437566937449841 1.0 0.3372306323842076 30 Q9Y4I1,Q9UQB8,Q7L576,P05067 4 +Er membrane insertion complex 0.5162561579221419 1.4487999647247094 0.1473934536523327 1.0 0.34127283325106 3 P46379 1 +Golgi associated vesicle membrane 0.4879841648471514 1.4469796809919746 0.1479026145103588 1.0 0.34127283325106 19 P24390 1 +Proton transporting v type atpase complex 0.5367462770885488 1.4451028180269287 0.1484290075652552 1.0 0.34127283325106 12 Q8N511,Q9Y487,Q93050 3 +Intrinsic component of golgi membrane 0.6043848650898446 1.4431338218556542 0.1489827773757295 1.0 0.341672236889747 9 L0R6Q1,Q8TB61,O15258,Q9Y282,P98194 5 +Nuclear inner membrane 0.4869177988698067 1.4397352475404783 0.1499423170953127 1.0 0.3422306547607225 19 Q14739,Q9UH99,O75844,Q99720 4 +Apical junction complex 0.4360233908876403 1.4279229836798153 0.1533140273897997 1.0 0.3480538147056312 28 P61586,Q9NR77,Q9Y4G8 3 +Microbody 0.3701632026206285 1.4233182243081683 0.1546439262851726 1.0 0.3493087681667593 52 P08670,Q8N4Q0,P50542,Q9Y4I1,Q9NR77,O00116,O15254,Q9UKG9 8 +Sarcoplasmic reticulum membrane 0.6352413454236596 1.3974263608607278 0.1622853966477109 1.0 0.3611251771937923 7 Q13557,Q13555 2 +Sperm connecting piece 0.4549966909331689 1.381612302473762 0.1670907744925465 1.0 0.370900262392097 2 P10644 1 +Chromaffin granule membrane 0.4530112508272789 1.369402720831409 0.1708734242371858 1.0 0.3755873065751347 2 P30626 1 +Side of membrane 0.3503460277266947 1.3656955190926303 0.1720345513607732 1.0 0.3762994201297693 64 P04439,O96005,P10321,P00813,P61586,Q9BZE9,P42892,P10619,Q9NV70,P35579,P41440,O15111,P08183,P00390,Q9Y5X1 15 +Aster 0.5978030090161803 1.3613836367381231 0.1733924844721484 1.0 0.3783491348069451 5 P43034 1 +Coated vesicle membrane 0.3601140052571018 1.3529668024277282 0.176066236203968 1.0 0.3823274066361527 53 P55735,P04439,Q8N511,P10321,P11717,O43493,P49257,Q14108,P24390 9 +Dna replication factor c complex 0.6404442436326447 1.3370675549041833 0.1812005866810193 1.0 0.3897113096321444 6 P41440 1 +Outer membrane 0.3196237873057846 1.3339032315218518 0.1822355723787352 1.0 0.3900709037344832 84 P30536,Q9HCL2,Q9BUR5,Q9Y6C9,P09601,Q15388,Q13505,Q9NZJ7,Q9NS69,P21796,Q13057,O43169,Q709C8,Q92667,Q9BUK6,Q99720,Q6NUM9,Q99536,Q5VT66,P45880,P52789,Q9UBM7 22 +Intrinsic component of organelle membrane 0.3070514704327451 1.325570086604952 0.1849821400285662 1.0 0.3922144902964177 117 Q99595,P10321,Q8TB61,Q9BUR5,Q15125,Q9Y282,Q13505,O60830,Q9BUB7,P57088,Q86YN1,Q5SNT2,O15118,P04439,P42892,P13473,Q9UH99,O75844,Q86XL3,L0R6Q1,Q14739 21 +Plasma membrane region 0.2916627343348936 1.3195125052475307 0.186997832223478 1.0 0.3955275070091175 174 Q9UQB8,O43865,Q8WTV0,Q99523,P61586,O95425,Q99720,P09601,Q92542,Q14141,P08183,P41440,Q15043,P05067,P09493,Q9Y4G8 16 +Mitotic spindle astral microtubule 0.5418194574607278 1.3144195482987966 0.1887050555721572 1.0 0.3955275070091175 4 Q86Y91 1 +Nuclear outer membrane 0.5580171950184578 1.3128643177573955 0.1892286724292629 1.0 0.3956199453811798 10 Q8WXH0,Q6NUM9,Q9UBM7,Q99720 4 +Actin filament 0.3984545833777266 1.2975484479268484 0.1944425467320711 1.0 0.4046385405373426 35 Q53GG5,Q9Y4I1,P06753,P09493,P67936 5 +Azurophil granule membrane 0.4492264643233835 1.2935676683154569 0.1958147963317529 1.0 0.4065531221760874 21 P42785,P07602,O15260,O95298,P13473,Q9NZJ7,Q92542 7 +Respiratory chain complex iii 0.5907919354912056 1.2765108365287705 0.2017749985954218 1.0 0.4153766872542038 8 P31930,Q9UDW1,O14949,P22695 4 +Mcm complex 0.6150886766041029 1.2233976793308627 0.2211795294575136 1.0 0.4448331028686907 6 P33991,Q14566 2 +Derlin 1 retrotranslocation complex 0.5216141309428023 1.2102429417545444 0.2261856849040033 1.0 0.4515129790063227 4 Q9UBV2,P55072 2 +Nuclear replication fork 0.4734048599513809 1.206592305689044 0.2275891913971648 1.0 0.451661552022188 16 Q9UIG0,P09884,Q9H4L7 3 +Stereocilium membrane 0.4255459960291286 1.2001712794348018 0.2300728271239063 1.0 0.4550237065696355 2 O00159 1 +Clathrin coated endocytic vesicle 0.4617295300872654 1.173206479756186 0.2407130141921183 1.0 0.4704369559972051 17 Q14108,O43493 2 +Early endosome membrane 0.3735475025855422 1.1710979740732663 0.2415593981127157 1.0 0.4710670258206756 42 P04439,Q01968,P10321,Q9BZF3,Q9HC07,Q8IV08,Q96T51,Q4V328,Q06481,Q96L92,Q9UMY4,Q9P258,Q15043 13 +Condensin complex 0.564473408953986 1.148824335903977 0.2506284224031949 1.0 0.4855925684061902 8 P42695,Q86XI2 2 +Cell leading edge 0.300195683297456 1.135856648437183 0.2560165641588836 1.0 0.4917925025188812 111 Q9UQB8,P08670,P63167,Q9Y4I1,Q8IYI6,Q8WUW1,P61586,Q06481,Q7L576,P35580,P31751,P41440,Q10713,Q00535,P05067,P09493 16 +Secretory granule membrane 0.3269345989378956 1.132215865939468 0.2575436913529505 1.0 0.493671169565677 70 P10321,P11717,P63167,P61586,P42785,Q92542,P07602,O95298,Q06481,O15260,P13473,P30519,Q9NZJ7,O75131,Q93050 15 +Cleavage furrow 0.4333252094720319 1.1243306131360662 0.2608727959707568 1.0 0.4972988481081623 20 P35580,P61586,Q14141,O95425 4 +Commitment complex 0.5926055561109953 1.1226250800900797 0.2615967590684276 1.0 0.4972988481081623 6 P62316,P62318 2 +Plasma membrane raft 0.440371528878083 1.1225023865793315 0.2616488933872756 1.0 0.4972988481081623 19 Q8WTV0,P09601 2 +Pcg protein complex 0.5910486140662519 1.1156552085340423 0.2645697503859692 1.0 0.5017894632847812 6 O75530 1 +Paraspeckles 0.586816352707569 1.0967178569824343 0.2727647479161268 1.0 0.5119321678008308 6 Q15233,P52272,P23246 3 +Azurophil granule 0.3236937200688132 1.0916571810022475 0.2749838125295218 1.0 0.5150217655500837 70 Q9NZ32,P15586,P42785,O43681,O95298,Q9NZJ7,Q92542,O75131,P06280,P15289,P07602,Q05655,P08236,O15260,P10619,P13473,Q99536,P61916,P68371,P07437,O00462,P55072,P53634,P16278 24 +Oxidoreductase complex 0.3294965140182724 1.0898304179448794 0.2757878521234969 1.0 0.5150778830076244 56 O43169,Q9Y6M9,O14949,Q86Y39,P23378,P11182,P22695,P09622,O95298,P31930,O75251,P51970,Q96CU9,Q9UDW1 14 +Ficolin 1 rich granule membrane 0.4422823251148359 1.088986892572574 0.2761596658617073 1.0 0.5150778830076244 18 P42785,Q93050 2 +Lsm2 8 complex 0.5390674171599108 1.079751260284492 0.2802529605915662 1.0 0.520552503247558 5 P62310 1 +Filopodium tip 0.5328447056881712 1.0500120235928814 0.2937125847681463 1.0 0.5355935369301492 5 Q9Y4I1 1 +Endoplasmic reticulum golgi intermediate compartment 0.3444450174938587 1.0466805313095755 0.2952469458654883 1.0 0.5373016282046031 49 Q8N511,Q9Y3B3,Q969H8,P49257,Q10472,P24390,Q9BZE9,Q9Y282,P80303,O15260,P09429,P53634,Q9UHD1 13 +Cell division site 0.3955998305225346 1.045226179847513 0.2959184463881517 1.0 0.53743572384434 25 P61586,Q96CW5,O95425,P35580,Q14141 5 +Intrinsic component of mitochondrial inner membrane 0.3880490857669537 1.037553483302895 0.2994779837714167 1.0 0.5417116849305909 27 Q53H12,Q6P4A7,Q99595,O60830,Q9BUR5,P50336,Q13505 7 +U2af complex 0.4422376696458215 1.0336604791970032 0.3012949149397064 1.0 0.5427098952998666 3 P26368,Q15637 2 +Organelle inner membrane 0.2522073502614129 1.029130854316508 0.3034181891145859 1.0 0.5433724143705434 232 Q567V2,P00403,Q99595,Q9BUR5,Q9Y6C9,O60220,O95298,P22830,Q13505,Q9Y584,Q70HW3,O95831,O60830,Q9BUB7,P04818,O43772,P51970,Q5SNT2,Q9UDW1,Q86Y39,Q99720,P40939,Q9Y5J9,P31930,Q9H061,Q9UBX3,Q9UH99,O75844,P00846,Q69YU5,Q13423,Q14739,Q9Y619,Q9Y5L4,Q9H2D1,Q10713 36 +Dna replication preinitiation complex 0.5207441759078634 1.020262789163004 0.3076038460344366 1.0 0.5475957575939772 9 P33991,Q9BRT9,Q14566 3 +Lamellipodium 0.3220444819828615 1.0117659708287994 0.311649964079602 1.0 0.5506850781454335 61 Q9UQB8,P61586,Q7L576,P41440,P05067,Q00535 6 +Golgi membrane 0.2854215541290103 1.0115153230005915 0.3117698510190272 1.0 0.5506850781454335 120 P10321,P11717,Q8TB61,Q9BUR5,Q14108,P24390,Q9Y282,Q9UHD1,Q7LGA3,Q15392,Q10472,Q92896,P04439,O95197,O15260,O00461,Q8IV08,Q9HC07,P49257,L0R6Q1,Q10713 21 +Intrinsic component of endoplasmic reticulum membrane 0.3468987132247037 0.9946962982728104 0.3198839953855825 1.0 0.5594858207230325 46 P04439,Q86XL3,P10321,Q8TB61,Q15125,P57088,Q9Y282,Q86YN1,O75844 9 +Origin recognition complex 0.5624371726747767 0.9880036270154892 0.3231508718753662 1.0 0.5619199880385961 6 Q9Y619,Q9UFC0,P49736 3 +Lumenal side of membrane 0.5120002826215899 0.9763517435839912 0.3288901863840703 1.0 0.5696961031970698 9 P10619,P10321 2 +Replication fork 0.3617738170354031 0.9705421877076345 0.3317763068555679 1.0 0.571392528473478 35 P28340,P26358,Q9UIG0,P09884,P41440,P35250,Q96FZ2,Q9H4L7 8 +Apical part of cell 0.3306707112797931 0.9612423034597796 0.3364303505075483 1.0 0.5739303704622349 51 Q15154,O43865,P05023,Q99797,P36551,P53985,Q99538,P08183,P41440,Q9Y4G8,Q9NV70,P05067,Q15043 13 +Mitotic spindle midzone 0.5413773356054387 0.9612192460968216 0.336441941305448 1.0 0.5739303704622349 7 O43663,Q00839 2 +Phagocytic vesicle 0.3558050760702467 0.945378232979019 0.3444658108623426 1.0 0.5833604239738874 38 P04439,P10321,P08670,Q9Y487,Q06481,P13473,Q99570,Q93050 8 +Ruffle membrane 0.3761742300013855 0.943912429266788 0.3452143999489523 1.0 0.5833604239738874 28 Q06481,P61586,P31751,P09493 4 +Platelet alpha granule lumen 0.4491235276846974 0.9333016773586392 0.3506642293560891 1.0 0.5892469947497646 12 Q8NBX0 1 +Gemini of coiled bodies 0.5065236198136978 0.924938351043802 0.3549979761618997 1.0 0.5951104639734581 5 O75312,Q8TEQ6 2 +Actin based cell projection 0.3417940131299203 0.9227461275508496 0.35613952126554 1.0 0.5951104639734581 45 Q9Y4I1,Q9UQB8,Q7L576,P05067 4 +Protein kinase complex 0.384187786249427 0.9200817659788596 0.3575300321755075 1.0 0.5963256009754754 24 Q9Y6K9,Q9Y4W2,Q8IUD2,P11802,P12004,P24941,P78527,P13010,P49736,P10644,Q96T76,P06493,O15111,Q00535,P14635 15 +Zona pellucida receptor complex 0.5046606226259893 0.9161445160455016 0.3595911019771765 1.0 0.5971233089916876 5 P17987,P49368 2 +Integrator complex 0.4997353734709931 0.9150603742515492 0.3601599360048579 1.0 0.5971233089916876 9 Q9NVR2 1 +Iron sulfur cluster assembly complex 0.4207216153591482 0.914098414689961 0.3606651354643897 1.0 0.5971233089916876 3 Q86SX6,Q9H3K6 2 +Mcrd mediated mrna stability complex 0.5028121853715246 0.9074289339592232 0.3641800144670437 1.0 0.5983617604270661 5 Q14103 1 +Pole plasm 0.501016069415553 0.8989694886858541 0.3686689127092861 1.0 0.5998343862348624 5 Q9Y2W6 1 +Spliceosomal tri snrnp complex 0.3854445382461471 0.8959251415168681 0.3702927454013016 1.0 0.6008902132053613 23 Q9Y333,P62310,P55769,P62316,P62318 5 +Pericentric heterochromatin 0.4953763011326186 0.8933801545154746 0.3716536266347372 1.0 0.6020119105308627 9 P42695,P26358 2 +Tight junction 0.3782503965047488 0.8755770418088125 0.3812600107569879 1.0 0.6109674682184173 24 Q9NR77,Q9Y4G8 2 +Tricarboxylic acid cycle enzyme complex 0.4369451961462557 0.8632611051967741 0.3879939239183625 1.0 0.6158733226166333 12 P09622 1 +Intrinsic component of nuclear inner membrane 0.5176466601536205 0.8526534611293348 0.3938515062075898 1.0 0.620091951104419 7 Q9UH99,Q14739 2 +Platelet alpha granule 0.4094160826429919 0.8361263134059712 0.4030838466500945 1.0 0.6322353310175803 17 P05067,Q8NBX0 2 +Rough endoplasmic reticulum 0.3462054992209175 0.8338283394741804 0.4043777232760637 1.0 0.6322357795220545 35 Q9UQB8 1 +Filamentous actin 0.444600348978469 0.8056996587949194 0.4204160463037962 1.0 0.6538996983168042 11 Q53GG5 1 +Perinuclear region of cytoplasm 0.2635944271820091 0.7969445775826676 0.4254832198570648 1.0 0.6594989907784505 178 O14976,P84085,Q9BZF3,P11717,P43034,P63244,P09601,Q99538,Q96F07,O14965,Q93050,P49815,O95831,Q10472,P55145,P62753,Q7L576,Q66K74,P05067,O15118,P27695,Q05655,O75569,Q8IYI6,Q99523,Q9Y487,O15027,O95684,P42892,Q7L5N1,Q9BZE9,Q99598,Q9Y4G8,Q9UIQ6,P16278,P30044,O75503,Q9NV70,Q9Y217,P16989 40 +Ribbon synapse 0.3988745448526946 0.7945668573973891 0.426865503718479 1.0 0.6597944371865877 3 P56545,P11142 2 +Spectrin 0.4398807192892991 0.7937113757701968 0.4273634761837348 1.0 0.6597944371865877 4 Q01082,O15020 2 +Apical plasma membrane 0.3356807094283776 0.7857306209624163 0.4320253198918129 1.0 0.6629654721000886 40 O43865,P05023,Q99797,P36551,P53985,P08183,P41440,Q9Y4G8,Q9NV70,Q15043 10 +Contractile ring 0.4339688302849414 0.7644393460170674 0.4446054689784788 1.0 0.6739050783180601 4 P35579 1 +Synaptic membrane 0.3315209108216102 0.7601958292639044 0.4471375376597968 1.0 0.675360638528452 41 Q9UQB8,Q99720 2 +Membrane microdomain 0.300194034234611 0.757938930435868 0.4484875430494837 1.0 0.675360638528452 58 Q8WTV0,P09601,P41440,P05067,O15118,P21796 6 +Camp dependent protein kinase complex 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.6819756174839091 2 P10644 1 +Nucleotide activated protein kinase complex 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.6819756174839091 2 P10644 1 +Neuromuscular junction 0.4083950944862511 0.7437706964698235 0.4570152110604795 1.0 0.6844293678084363 14 P05067,Q00535,P35579,P11047 4 +Pore complex 0.479367077058435 0.7428787092145941 0.4575551168552505 1.0 0.6844293678084363 8 P45880 1 +Sarcoplasmic reticulum lumen 0.4282505474224062 0.7363170807773094 0.4615377536895284 1.0 0.6880969163629951 4 O43852 1 +Lamellipodium membrane 0.427814569536407 0.7341811940742503 0.4628383134945677 1.0 0.6888934500523449 4 Q9Y2A7,Q8WXH0,P23528 3 +U6 snrnp 0.5032396423099956 0.7296109477655411 0.4656280284225542 1.0 0.6906543446957288 6 P62310 1 +Clathrin coated vesicle 0.3262648695032086 0.7253338103944296 0.4682472684363816 1.0 0.6916994310387932 42 O43493,Q5VW38,Q99523,Q14108,P42892 5 +Smn sm protein complex 0.4456043701095031 0.7248067693453436 0.4685705823166017 1.0 0.6916994310387932 10 P62316,P62314,P62304,Q8TEQ6,P62318 5 +Nuclear envelope lumen 0.4607426593239896 0.712524598255573 0.4761399847957483 1.0 0.7005915610036084 5 P05067 1 +Scar complex 0.4937101902703744 0.6892678907553533 0.4906547002588191 1.0 0.713352746411578 6 Q8WUW1,Q7L576 2 +Ciliary base 0.455500027538368 0.6888440246872449 0.4909214276460558 1.0 0.713352746411578 5 Q8TD19,A0AVF1 2 +Outer mitochondrial membrane protein complex 0.3948278231025373 0.6885486600859028 0.4911073386060502 1.0 0.713352746411578 15 Q9BUR5,Q9NS69,Q13505 3 +Nuclear pore 0.3154176583998208 0.6874746634984791 0.4917836615544488 1.0 0.713352746411578 46 P55735,O00410,Q5JVF3,Q9C0E2,Q92621,Q8WUX9,P62826,Q8NFH4,P61970,Q8N1F7,Q8NFH3,Q5SRE5,Q9BTX1,P49792 14 +U5 snrnp 0.4222906042500437 0.6871830070184418 0.4919674113183296 1.0 0.713352746411578 11 Q6P2Q9,P62316,P62314,Q96DI7,P62318 5 +Mitochondria associated endoplasmic reticulum membrane 0.4370945504721326 0.6822107069971417 0.4951057253437885 1.0 0.7166264545989621 10 O43865,Q96N66 2 +Trans golgi network transport vesicle 0.3983563150973378 0.6650458674559802 0.5060211564498927 1.0 0.7253077018589922 13 Q99523,O43493 2 +Actomyosin 0.3320123839193086 0.6635740652929834 0.506962960860847 1.0 0.7253077018589922 31 Q53GG5,P06753,P35580,P09493,P67936 5 +Azurophil granule lumen 0.3157915565814018 0.6578448527765308 0.5106378298091307 1.0 0.7261290120710611 44 P15586,Q05655,P68371,P07437,P06280,P15289,P08236,P55072,O43681,P10619,P53634,P16278,Q99536,P61916 14 +Microbody lumen 0.3647509285854614 0.65559221861748 0.5120865335406593 1.0 0.7261290120710611 20 O15254,O00116,Q9UKG9,Q15067 4 +Ciliary plasm 0.3871858933264483 0.6439882908611888 0.5195830268967709 1.0 0.731379418411123 15 Q10713,Q9BZH6 2 +Contractile fiber 0.2962299477989001 0.6309369929300302 0.5280817226533481 1.0 0.7371824047598756 52 Q53GG5,P49257,O95425,P06753,P09493,P67936 6 +U7 snrnp 0.3650931034570426 0.6161002329885318 0.5378283683230192 1.0 0.7464454094609685 3 P62318 1 +Respirasome 0.3122356570720009 0.5991496098369354 0.5490731218906957 1.0 0.7570808843247475 42 Q9Y6M9,P20674,P00403,P08574,P14406,O14949,Q86Y39,P14854,Q13423,P22695,O95298,P31930,O75251,P51970,Q96CU9,Q9UDW1 16 +Cytochrome complex 0.3661251393526173 0.59764317422354 0.5500780497982238 1.0 0.7573050027084276 18 P08574,P20674,P00403,P14406,O14949,P22695,P31930,Q9UDW1 8 +Inner mitochondrial membrane protein complex 0.2801371646770984 0.5865729075002704 0.557490582721796 1.0 0.762142216658529 74 P00403,Q99595,P14406,O14949,Q9BUR5,O95298,O75251,Q13505,Q9Y584,O60830,P51970,Q96CU9,Q9UDW1,Q53H12,Q9Y6M9,P20674,Q86Y39,P22695,P31930,Q9Y512,P08574,P00846,P56134 23 +Cell cell junction 0.2654396893661188 0.5860670549463077 0.5578304544619712 1.0 0.762142216658529 109 Q53GG5,Q9UQB8,Q6XZF7,P61586,Q9NR77,P16989,P05067,Q9Y4G8 8 +Myosin complex 0.400725385705786 0.5764171238887551 0.5643332727514481 1.0 0.7686903215205331 11 Q9Y4I1,P35580,P60660 3 +Cell trailing edge 0.4627669588563508 0.561998891220182 0.5741167745511946 1.0 0.7749714419242102 6 P41440 1 +Proton transporting two sector atpase complex proton transporting domain 0.3949652032300773 0.5476356028546735 0.5839421379164789 1.0 0.7815134269681292 11 P00846,Q9Y487,Q93050 3 +Transporter complex 0.2919558901399102 0.5423249599171989 0.5875946638912675 1.0 0.782743189683105 50 Q9Y6M9,O14949,Q86Y39,O95298,O60220,Q9Y5J9,P31930,O75251,P51970,Q9Y5L4,Q96CU9,Q9UDW1 12 +Small subunit processome 0.3118253477082789 0.538604208111657 0.5901599833132565 1.0 0.7848429363884876 33 P55769,Q68CQ4,P78527 3 +Proton transporting two sector atpase complex 0.3306527502461224 0.5319351720789661 0.5947708960647475 1.0 0.7870542402792623 24 Q8N511,Q93050 2 +Spindle microtubule 0.3101885396975023 0.5246369405385103 0.5998356017721336 1.0 0.7906923841541761 32 O94927,O43663,Q96CW5,O14965,Q96CS2,Q9H6D7,Q00839 7 +Cytoplasmic side of endoplasmic reticulum membrane 0.4415670050089061 0.5218551854794647 0.60177116282971 1.0 0.7920823944127515 7 P62273,P31689,Q6YHU6 3 +Core mediator complex 0.4519649513557756 0.5192100657493401 0.6036142604741412 1.0 0.793346813108557 6 O60244,O75448 2 +Axonal growth cone 0.4486174670506319 0.5061518318588277 0.6127500664609424 1.0 0.8006719618435861 6 Q7L576 1 +Secretory granule 0.2287791268482716 0.4923540466151511 0.6224690791015846 1.0 0.8093430411985613 233 Q9UQB8,P15586,P10321,P11717,P42785,O43681,O95298,Q92542,Q93050,P14174,Q9Y4I1,P61586,Q8NBX0,P07602,P09622,Q7L576,P30519,P05067,P42892,Q06481,O15260,P10619,P61916,P45880,P53634,P16278 26 +Leading edge membrane 0.3011075799690856 0.4845953908577841 0.627963383843452 1.0 0.8093430411985613 40 Q06481,P61586,P31751,P09493 4 +Microtubule organizing center attachment site 0.3736092488871934 0.481011183554411 0.630508550328968 1.0 0.8093430411985613 4 Q9UH99 1 +Organelle membrane contact site 0.3541455927029797 0.4786142568459555 0.6322130740316934 1.0 0.8093430411985613 16 Q14849,O43865,Q15388,Q96N66 4 +Centriole 0.3225572429353058 0.4771045611607177 0.6332876669016783 1.0 0.8093430411985613 24 P27695,Q9Y6A4,O95684,P62826,Q96CW5,O14965 6 +Envelope 0.2327101524959683 0.4742260042655751 0.6353387515297948 1.0 0.8093430411985613 459 P30536,Q567V2,P00403,Q99595,Q9BZF3,P11717,Q9HCL2,Q9BUR5,Q9Y6C9,Q15125,P09601,O60220,O95298,Q5SRE5,P22830,Q13505,Q9NS69,Q9Y584,Q9NZJ7,Q8N201,Q70HW3,P21796,P55735,O43169,O95831,O60830,Q5JVF3,Q9UI26,Q9BUB7,P04818,O43772,P51970,P05067,Q9UDW1,O15118,P09874,Q86Y39,Q99523,Q99720,P40939,Q9Y5J9,Q6NUM9,P31930,P09884,Q9H061,Q9UBX3,Q9UH99,O75844,O14880,P00846,O75531,P45880,Q69YU5,Q8NFH4,Q13423,P80303,Q9BTX1,Q14739,Q9Y619,Q9Y5L4,Q9H2D1,Q10713 62 +Hrd1p ubiquitin ligase erad l complex 0.3363124793114791 0.4737110815018133 0.6357059499898934 1.0 0.8093430411985613 3 Q9UBV2,Q9BUN8 2 +Er ubiquitin ligase complex 0.3363124793114791 0.4737110815018133 0.6357059499898934 1.0 0.8093430411985613 3 Q9UBV2,Q9BUN8 2 +Copii coated er to golgi transport vesicle 0.3071020492295861 0.4697965029493927 0.6385004131172467 1.0 0.8099204873993802 31 P55735,P04439,P10321,P49257,O15027,Q9Y282,P53634,Q9Y3B3,P05067 9 +Nuclear lamina 0.3994700231864924 0.4493153688894116 0.6532041725382407 1.0 0.8221736553456496 5 P50747,P02545,P12004,P56537 4 +Condensed chromosome centromeric region 0.2702119866687232 0.4485415824001399 0.6537623830883716 1.0 0.8221736553456496 68 P55735,P63167,Q14807,Q8NFH4,Q8NBT2,P42695,Q8IWS0,Q96DY7,Q8NFH3,Q14141,Q9UFC0,Q5T280,Q00839 13 +Precatalytic spliceosome 0.2988525445079648 0.4481414161858712 0.6540511395352675 1.0 0.8221736553456496 37 Q15428,Q9Y333,Q9Y3B4,Q9HCG8,P62310,P55769,P62316,P62314,P62318 9 +Replisome 0.3874586988666504 0.4469309828610021 0.6549248927456515 1.0 0.8221736553456496 10 P09884 1 +Clathrin coated vesicle membrane 0.3262491022010016 0.4444419694406315 0.6567230756154685 1.0 0.8221736553456496 21 Q14108,O43493 2 +Nuclear pore nuclear basket 0.4205523571779179 0.4383069126315501 0.6611638155920145 1.0 0.825536486412807 7 Q5JVF3 1 +Glutamatergic synapse 0.2690326789598303 0.4260119098235936 0.6700991676572632 1.0 0.8320706515523199 64 Q9UQB8,P07737,P61586,Q13526,P41440,Q00535 6 +Midbody 0.2506230788454595 0.4123359342462248 0.6800932137120914 1.0 0.8406007919363137 82 P63244,P60953,Q14141,O14965,Q6DKK2,Q9NR09,Q13526,P61586,P62826,Q8NBX0,P35580,Q14166,O95785,P84090,Q00839,O43663,Q8TAG9,Q8WUX9,O95425,Q99816,Q96KP1,Q9P258,O14530,Q9NV70 24 +Rnai effector complex 0.4235765333543858 0.4119147452799761 0.6804019126766514 1.0 0.8406007919363137 6 Q9HAV4,P06730,Q08211 3 +Clathrin coated pit 0.312474321890915 0.4109581073903052 0.6811032532359864 1.0 0.8406007919363137 24 P05067 1 +Annulate lamellae 0.354784702716712 0.4009651626582075 0.688445772920117 1.0 0.8443557296796523 4 Q9Y5L0,P49792 2 +Nuclear envelope 0.243910055185486 0.3931802493661271 0.6941863561936645 1.0 0.8502364226404693 165 Q9BZF3,P11717,Q15125,Q5SRE5,Q8N201,P55735,Q5JVF3,Q9UI26,P57088,P05067,O15118,P09874,Q99523,Q99720,Q6NUM9,P09884,Q9UH99,O75844,O14880,O75531,Q8NFH4,P80303,Q9BTX1,Q14739 24 +Actin filament bundle 0.2904740508389699 0.376023009660772 0.706899789998372 1.0 0.8620057604774406 32 Q53GG5,P09493,P67936 3 +U4 snrnp 0.4037949425425757 0.3752463593554849 0.7074772551569919 1.0 0.8620057604774406 7 P62316,P62318 2 +Smn complex 0.3786021861543689 0.3687420606631836 0.7123199946811534 1.0 0.8620057604774406 5 Q9UHI6,Q8TEQ6,Q9Y3F4,P57678 4 +Er to golgi transport vesicle membrane 0.310766204264735 0.3657458384908801 0.7145547382422361 1.0 0.8634203087093687 22 P55735,P04439,P10321,P49257,O15027,Q9Y3B3 6 +Organelle envelope lumen 0.28717567529069 0.3625458001027989 0.7169442044438914 1.0 0.8647277458802594 38 O95831,Q9Y5J9,O60220,P51970,Q9Y5L4,P05067 6 +Ficolin 1 rich granule 0.247769546900751 0.3531000808043528 0.724013412309612 1.0 0.8701712000886915 85 P14174,P61586,P42785,P16278,Q93050 5 +Mediator complex 0.3591760342959968 0.3272039359720429 0.743513644126407 1.0 0.8864970372276391 10 O75448,P11802,Q13503,Q9NYF8,O60244 5 +Cytosolic large ribosomal subunit 0.2754551189075392 0.3228044028390679 0.7468433783901665 1.0 0.8880478713982601 45 P61927,P46776,Q02543,P61313,P46777,P50914,P49207,P62888,P39023,P36578,P18621,P62910,P62917,Q07020 14 +Preribosome small subunit precursor 0.3459091014704801 0.3216171878408627 0.7477427211250898 1.0 0.8880478713982601 11 Q9BVI4,Q2NL82,Q9ULX3,O75691 4 +P body 0.2827864823088426 0.3212372029959143 0.7480306410178175 1.0 0.8880478713982601 34 P62310,Q9Y333,P19474 3 +Neuron projection cytoplasm 0.2814958644269761 0.3127979565258162 0.7544341679962332 1.0 0.8900739068616977 32 Q9UQB8,P27695,P43034,O14617,O60828,Q00839 6 +Microtubule 0.2399580679452466 0.3085364685173363 0.7576741549471313 1.0 0.8927248562221114 120 Q9UQB8,O94927,P63167,P43034,P17987,P50748,O14965,Q00535,Q96JB5,Q14807,P49368,Q86TI2,Q96CS2,Q66K74,Q96ED9,Q9BTW9,Q07866,Q08379,Q00839,Q9Y6A4,O43663,Q8WUX9,O95425,Q99426,Q9BRK4,Q9H6D7,Q9P258,P68371,P07437,Q9BUF5,Q96CW5 31 +Spindle midzone 0.3106056183882331 0.3049258074576149 0.7604226596911889 1.0 0.893620877205724 19 O43663,P05067,O14965,Q00839 4 +Cytoplasmic ubiquitin ligase complex 0.3905589368485885 0.2987917334564719 0.7650989587303694 1.0 0.8963418570806694 6 Q9NT62 1 +U2 snrnp 0.3177555691923602 0.2796827553534297 0.7797209097799613 1.0 0.9079910594458358 15 P62316,P62314,Q9Y3B4,P62318 4 +Copi vesicle coat 0.3517568026231834 0.2596160347955192 0.7951599663609914 1.0 0.9188034398859832 9 Q9Y3B3,Q9Y678,P53618,P35606 4 +Aggresome 0.377845199622666 0.2592570389742279 0.7954369243228909 1.0 0.9188034398859832 6 P13639,P28340 2 +Chaperonin containing t complex 0.3607551584264743 0.2580521514116813 0.7963666587876246 1.0 0.9188034398859832 8 P49368,P17987,Q99832 3 +Cul4 ring e3 ubiquitin ligase complex 0.3767091346464361 0.2558444040598759 0.798070985166262 1.0 0.9188034398859832 6 Q9NV06,P61962,Q92990 3 +X chromosome 0.3132402784762643 0.2454603020595652 0.8061000424231515 1.0 0.9225609989486152 4 P24941,A6NHR9 2 +Telomerase holoenzyme complex 0.3132880719495992 0.2434903152925639 0.8076255866744848 1.0 0.9225609989486152 13 Q15185,P62318 2 +Crd mediated mrna stability complex 0.372495301494922 0.2433642331822007 0.8077232487774626 1.0 0.9225609989486152 6 Q08211,Q00839 2 +Transcription factor tfiiic complex 0.3407794147318683 0.2395175028061823 0.8107043261061246 1.0 0.9225609989486152 5 Q8WUA4 1 +Rna polymerase iii transcription regulator complex 0.3407794147318683 0.2395175028061823 0.8107043261061246 1.0 0.9225609989486152 5 Q8WUA4 1 +Lumenal side of endoplasmic reticulum membrane 0.3605292882617379 0.2307280115240883 0.8175261105499183 1.0 0.925637246076041 7 P10321 1 +Spindle pole centrosome 0.3447415290790829 0.2076772988939753 0.8354809440773456 1.0 0.9351013665326582 8 O14965 1 +Endoplasmic reticulum lumen 0.2443224557356572 0.2046158635893812 0.8378722602799358 1.0 0.9351013665326582 58 O43493,Q14257,Q9NZ08,Q06481,O43681,O43852,P05067,Q9BV10 8 +Barr body 0.2697782191327282 0.2026521834506785 0.8394068996572359 1.0 0.9351013665326582 3 Q9P0M6,A6NHR9 2 +Polymeric cytoskeletal fiber 0.2303427047014758 0.194445981414457 0.84582668895348 1.0 0.9399236011979956 170 Q9UQB8,O94927,P63167,O14965,Q00535,P07197,P08670,Q9Y4I1,Q14807,P49368,P06753,Q96CS2,Q66K74,Q96ED9,P09493,Q00839,Q9BTW9,Q53GG5,Q9Y6A4,O43663,O95425,Q9H6D7,P68371,Q9BUF5,Q96CW5,P67936,Q69YQ0 27 +Cytoplasmic region 0.2428339216736609 0.1898846642638005 0.8493995099807505 1.0 0.9406922954398808 59 Q9UQB8,P27695,Q9BZH6,P43034,O14617,O60828,Q99570,Q10713,Q00839 9 +Nuclear periphery 0.2427983251245189 0.187272412044447 0.8514470523079147 1.0 0.9410253664457752 60 Q8WXF1,P60900,P52272,O14929,Q92621,P08670,Q9UPW6,Q15233,P27708,Q00839,Q05655,Q5BKZ1,Q8N1F7,Q13427,P09884,Q9Y6X9,O43823,P23246,P43243 19 +Stereocilium bundle 0.3365384615384635 0.1837798309695352 0.8541861791849408 1.0 0.9410703126069384 8 Q6IBS0,Q00013,O14745,Q9Y6M7,P43034,Q9HBM0,O00159 7 +Adherens junction 0.2555795338524617 0.177873728632484 0.8588221433240013 1.0 0.9450197146245742 45 Q53GG5,Q9UQB8 2 +Dynactin complex 0.3185958035783079 0.1757692178471108 0.8604752536938212 1.0 0.945250017995418 5 Q9NZ32 1 +Nadh dehydrogenase complex 0.2752617930053886 0.1680235258248592 0.8665647712574693 1.0 0.94773933012222 21 Q86Y39,O95298,O75251,P51970,Q96CU9 5 +Rdna heterochromatin 0.2575306190003213 0.164707895315703 0.8691739022987925 1.0 0.948285604571134 3 O43159,Q9UIF9 2 +Intrinsic component of mitochondrial membrane 0.2563696344707669 0.1616147256229022 0.8716092603963979 1.0 0.9497899698137716 41 Q9BUR5,Q9BUB7,Q99595,O60830 4 +Exoribonuclease complex 0.28809167236159 0.1579631245747504 0.8744858561655489 1.0 0.9500526163117404 15 Q9Y3B2,Q9Y4W2 2 +Catalytic step 2 spliceosome 0.2395277789834851 0.1578074365527694 0.8746085385666629 1.0 0.9500526163117404 69 P52272,Q9UK45,Q9Y333,O60506,Q92620,P31943,P62318,Q9Y3B4,P52597,P17844,O75934,P38159,Q00839,Q15428,O43390,Q6NZY4,P62314,P51991,P62304,Q6P2Q9,P61978,Q9HCG8,P62310,P62316,Q96DI7 25 +Golgi apparatus subcompartment 0.2269001488279361 0.1541447146973832 0.8774956323395846 1.0 0.950084935065746 82 O43493,Q9HC07,Q9BZH6,Q6XZF7,P11717,Q99523,Q10472,O00461,Q96ED9,P05067,Q10713 11 +Transferase complex transferring phosphorus containing groups 0.238800890101849 0.1532249394799629 0.8782208910340767 1.0 0.950084935065746 72 P11802,P17858,P29083,Q9H9Y6,Q9NRF9,Q00535,Q92541,Q9Y6K9,P62875,Q9NRG0,Q9NR33,P78527,P09884,Q96T76,O15111,Q99570,Q9NQG5,Q9Y4W2,O00443,P28340,P30876,P49736,Q07864 23 +Chromosome telomeric repeat region 0.2791390728476733 0.1450670115275172 0.8846579637166532 1.0 0.9547509116221744 4 Q9NYB0,P12956,P13010 3 +Vesicle lumen 0.2242419452274484 0.131155361049574 0.8956524075633574 1.0 0.9618306169252688 123 P15586,P14174,P00813,Q8NBX0,P10619,P16278,O43681,P61916,P05067 9 +Protein phosphatase type 1 complex 0.2448542403982751 0.1299988198617111 0.8965673603819526 1.0 0.9618306169252688 3 P62140 1 +U12 type spliceosomal complex 0.2774317388236936 0.1208601305021487 0.9038018218622884 1.0 0.9646103484888549 15 P62316,Q9Y3B4,P62318 3 +Recycling endosome 0.250549582073044 0.1200348333716769 0.904455554398046 1.0 0.9646103484888549 34 P04439,P10321,Q9Y4I1,Q4V328,P05067 5 +Rna cap binding complex 0.3178650544127138 0.1199492051701491 0.9045233857353778 1.0 0.9646103484888549 7 Q7L576 1 +Cop9 signalosome 0.2959846811437257 0.1169481452925067 0.906901145459124 1.0 0.9648861106079926 10 Q9UBW8,Q7L5N1 2 +Motile cilium 0.2570301637734229 0.1155592819935446 0.9080018348991789 1.0 0.9648861106079926 25 P43034,Q9Y6A4,P62826,P09622,Q14141,Q15388 6 +Cell projection membrane 0.231526647230166 0.1079261476063868 0.914054275474346 1.0 0.970170948821059 58 P61586,Q06481,P31751,P41440,P09493 5 +Podosome 0.2738007566885087 0.1040026750884494 0.9171672256715536 1.0 0.9723270470268004 12 P67936 1 +Basal part of cell 0.2433467359785583 0.0924923242880001 0.9263068894116756 1.0 0.9797057571542312 43 P42785,Q15043 2 +Condensed chromosome 0.226033953854768 0.0828044805534277 0.9340070063990668 1.0 0.9866889527059473 101 P63167,P42695,Q96DY7,Q14141,P55735,Q9UEY8,Q14807,Q9UFC0,Q8IY18,Q00839,O43823,O75531,Q8NFH4,Q8NBT2,Q8IWS0,P09429,Q8NFH3,Q5T280,Q9UIG0 19 +Cyclin dependent protein kinase holoenzyme complex 0.2701519186029154 0.073208805795705 0.941639959181756 1.0 0.9892479901553828 11 P12004,P11802,P49736,P06493,Q00535,P14635 6 +Nucleocytoplasmic transport complex 0.2891246684350159 0.073045498100105 0.9417699119392448 1.0 0.9892479901553828 8 Q14974,Q9HAV4,P62826,O00505,P52294,P52292,Q9BQG0 7 +Photoreceptor inner segment 0.2450331125827748 0.0728426321888341 0.9419313454649696 1.0 0.9892479901553828 4 P05023,Q9HCM4,P35613 3 +Neuron projection membrane 0.286140583554375 0.0676785075821229 0.946041558540676 1.0 0.990440602080023 8 Q01082,O94832,Q9HBM0,P20020,Q9Y2J2,Q14168,O00159 7 +Autophagosome 0.2526315435779066 0.0673344191759207 0.9463154765156812 1.0 0.990440602080023 20 P27695,P13473,P19474 3 +Polysomal ribosome 0.2450045760176054 0.0662306896449771 0.9471941636043943 1.0 0.990440602080023 26 P83731,P62273,Q02543,P63173,Q08211,P62888,P62266,P62913,P62910,P62917,Q07020 11 +Vcp npl4 ufd1 aaa atpase complex 0.2799867461895249 0.0478281956861846 0.9618531653566034 1.0 1.0 6 Q92890,Q9UNN5,P55072,Q04323,Q8TAT6 5 +Cluster of actin based cell projections 0.231864698234887 0.034605561492261 0.9723942667281328 1.0 1.0 32 Q9UEY8,P60660,P43034,Q13045,P35579,P41440 6 +Chromosome centromeric region 0.2190556923089101 0.0340105804385879 0.972868713613288 1.0 1.0 90 P55735,P26358,P63167,Q8NFH4,Q14807,Q8NBT2,P42695,Q8IWS0,Q96DY7,Q8NFH3,Q14141,Q9UFC0,Q8IY18,Q5T280,Q9P258,Q00839 16 +Nuclear inclusion body 0.2533996683250396 0.023952972888576 0.9808901201303986 1.0 1.0 9 P12270,P49790,Q9NS91,P52948,Q9UBU9,P49792,Q9UNE7,Q86U42 8 +Proteasome core complex alpha subunit complex 0.2491287936686466 0.0154816370471413 0.9876479342521912 1.0 1.0 7 P60900 1 +Anchoring junction 0.2042198773394843 0.0069076563392619 0.9944885314862169 1.0 1.0 245 Q9UQB8,O14976,Q15417,O15484,P11717,P63167,Q14108,Q9NR77,Q99797,Q6WCQ1,P35579,Q9UHD1,Q92542,O75131,P62917,Q07020,P07737,Q9UEY8,P08670,Q6XZF7,P61586,P39023,Q7L576,P36578,P84095,P41440,P05067,Q9BTW9,Q53GG5,O95425,Q15366,Q9Y4G8,P62888,P67936,Q10713,P16989,Q69YQ0 37 +Proteasome complex 0.2218015102464735 0.0003980200249205 0.9996824259756104 1.0 1.0 47 P60900,P61289,P49721,O75832,P28074 5 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a4e62552433d9dc8537e6177071ea71119a13ce0 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fhf complex", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Photoreceptor connecting cilium", "Photoreceptor disc membrane", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spherical high density lipoprotein particle", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADNP", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC8", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BIRC6", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRI3BP", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf57", "C12orf73", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CAST", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC51", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD8", "CHERP", "CHID1", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA7", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPAGT1", "DPF2", "DPM1", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP4", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGCX", "GGH", "GHDC", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPHN", "GPI", "GPR107", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOOK2", "HP1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "ISCU", "ISG20L2", "ISOC1", "IST1", "ISY1", "ITCH", "ITGB1", "ITM2B", "ITPK1", "ITSN2", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRWD1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTS2", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METTL13", "MFAP1", "MFN1", "MFN2", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFR1L", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NENF", "NES", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PECR", "PEF1", "PELP1", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPM1L", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SCAF1", "SCAF11", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAMM41", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM126A", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM70", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT112", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA5", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFD1", "UFL1", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13C", "VPS18", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WASF2", "WASHC4", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR61", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WRAP53", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC11", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYND8", "ZNF207", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZYG11B", "ZYX"], "leading_proteins": ["ABCB1", "ACOX1", "ACOX3", "ACTR10", "ADA", "ADD3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCYL1", "AIFM1", "AKAP1", "AKAP8", "AKT2", "ALG11", "ALG12", "ANKLE2", "AP3D1", "APEX1", "APLP2", "APOL2", "APOO", "APP", "ARF5", "ARSA", "ASNA1", "ASPSCR1", "ATG3", "ATP13A1", "ATP1A1", "ATP2B1", "ATP2C1", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "AURKA", "BAG6", "BAIAP2", "BANF1", "BAZ1B", "BAZ2A", "BCAS2", "BCLAF1", "BIRC6", "BOLA2*", "BRCA1", "BRK1", "BSG", "C12orf73", "CAD", "CALU", "CAMK2D", "CAMK2G", "CAPN5", "CCDC115", "CCNB1", "CCT3", "CCT7", "CDC42", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CFAP20", "CFL1", "CHMP7", "CHORDC1", "CHRAC1", "CHUK", "CLCC1", "CLIC1", "CLN5", "CLPTM1", "CNN3", "CNPY2", "COASY", "COG4", "COLEC12", "COPB1", "COPB2", "COPG1", "COPS6", "COPS7A", "COX2", "COX5A", "COX6B1", "COX7A2", "CPNE3", "CPOX", "CROT", "CTBP2", "CTSA", "CTSC", "CWC22", "CYB5B", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DBT", "DCAF13", "DCAF7", "DCTN1", "DDX20", "DDX5", "DERL1", "DHCR24", "DHCR7", "DHX38", "DHX9", "DIEXF", "DLD", "DNAJA1", "DNMBP", "DNMT1", "DOLPP1", "DPP9", "DYM", "DYNLL1", "EBP", "ECE1", "EED", "EEF2", "EIF4E", "EIF6", "ELOC", "EPB41L3", "EPB41L5", "EPHX1", "ERAP1", "ERC1", "ERGIC3", "ERH", "EXOC1", "EXOC2", "EXOC6", "EXOC8", "EXOSC1", "FADS2", "FAF1", "FASN", "FECH", "FGFR1OP", "FLII", "FOXRED1", "GAK", "GALNT1", "GEMIN4", "GEMIN5", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLRX5", "GNS", "GOLGA2", "GOLIM4", "GOLPH3", "GPAM", "GPR107", "GRIPAP1", "GSR", "GTF2E1", "GTF3C2", "GUSB", "H2AFY2", "HADHA", "HAT1", "HAUS1", "HAUS4", "HAUS5", "HK2", "HLA-A", "HLA-C", "HLCS", "HMCES", "HMGB1", "HMOX1", "HMOX2", "HNRNPA3", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HOOK2", "HS2ST1", "HSPA8", "ICMT", "IGF2R", "IKBKG", "INTS1", "INTS10", "IPO11", "IPO5", "KDELR1", "KDSR", "KIF18B", "KIF22", "KLC1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNB1", "LAMC1", "LAMP2", "LAS1L", "LBR", "LCLAT1", "LDAH", "LGMN", "LMAN1", "LMNA", "LNPEP", "LPCAT3", "LRWD1", "LSM2", "LSM3", "LSM7", "LSS", "LZTS2", "MANBA", "MANF", "MAP1S", "MARC1", "MARK2", "MATR3", "MBOAT7", "MCM2", "MCM4", "MCM6", "MED14", "MED21", "MED24", "MGST3", "MIF", "MIPEP", "MMS19", "MORC2", "MPP1", "MPP2", "MPRIP", "MPV17L2", "MSMO1", "MSTO1", "MTBP", "MTCH1", "MTCH2", "MTMR6", "MTX1", "MYBBP1A", "MYDGF", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO1D", "MYO5A", "NAA25", "NAPG", "NCAPD3", "NCAPG2", "NCKAP1", "NCSTN", "NDC1", "NDUFA11", "NDUFA8", "NDUFB9", "NDUFC2", "NDUFS7", "NEFM", "NEK9", "NENF", "NNT", "NOB1", "NOC4L", "NONO", "NPC1", "NPC2", "NPLOC4", "NUCB2", "NUP153", "NUP188", "NUP205", "NUP37", "NUP43", "NUP93", "NUP98", "NUTF2", "NXF1", "OCRL", "OSBPL6", "PABPN1", "PAFAH1B1", "PARP1", "PCBP2", "PCID2", "PCM1", "PCNA", "PCYOX1", "PDE6D", "PDLIM3", "PEX5", "PFKL", "PFN1", "PHF6", "PIK3C2A", "PIK3R4", "PIN1", "PLA2G15", "PLBD2", "PLD3", "PMPCA", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1B", "POLR2B", "POLR2L", "PON2", "PPIG", "PPOX", "PPP1CB", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX5", "PRKAR1A", "PRKCD", "PRKDC", "PRKRA", "PRPF8", "PSAP", "PSMA6", "PSMB2", "PSMB5", "PSMD10", "PSME3", "PSPC1", "PTGES3", "PTPRF", "PXMP2", "RACK1", "RAD18", "RAN", "RANBP2", "RAPGEF2", "RBMX", "RCC2", "RCN2", "RER1", "RETSAT", "RFC2", "RHOA", "RHOG", "RPL11", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL24", "RPL27A", 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setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Transporter activity 37 157 4.818723078883899 1.444799214711523e-06 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 3.266073834813902e-05 3.159881303904587e-05 2.384298950418844e-06 4.967881955133319e-05 +Lipid binding 34 134 3.699925415235873 0.0002156628399712 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 0.0013982202745197 0.0011951654800798 0.0057878972723881 0.0186001904714013 +Peptidase activity 34 108 3.5010417129332017 0.0004634432991934 29.021844660194176 113.626213592233 1.2572335980018865 0.3731282983707893 8.334453494010912 9.805689463637474 1.5136028692995414 0.3922229485757941 0.0542732260417351 6.871636595207527e-07 7.766804090450395e-05 8.130418908429529e-05 +Exopeptidase activity 9 33 3.33735331509955 0.000845803541458 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 0.0032700867405931 1.0564625302288573e-07 1.7839068863531593e-07 5.478593541938059e-06 +Steroid binding 7 21 3.2517083976307912 0.0011471364573627 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 0.0017444833819082 0.0001009929501613 0.0001541210820523 0.0022658484440293 +Sterol binding 7 16 3.2217006247979136 0.0012743221065969 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 0.0007069993740851 2.2037872854000083e-05 1.953959903017768e-05 0.0002645246913318 +Cholesterol binding 7 13 3.158453206150752 0.0015860877024247 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0004104233816526 8.719376349895246e-06 5.389312886506094e-06 6.616615234342882e-05 +Alcohol binding 7 16 3.1283957179853714 0.0017576336854612 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0018494623097264 0.0001113664394611 0.0001755897066278 0.0005879318152671 +Transition metal ion binding 44 180 3.0690728099859323 0.0021472425240078 36.75970873786408 189.9271844660194 0.0666561204764537 0.7651506972740183 13.032000491419966 22.89517138296398 0.6734214621869332 0.3106060226933 0.2039481147127314 0.0081502885160268 0.0030861382386796 0.0076263935707532 +Protein transporter activity 5 15 2.953241420216779 0.0031445593218746 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0002365528693072 3.3768958612978955e-06 2.1849572487781167e-05 0.000136356004925 +Lipid transporter activity 4 16 2.9396855527277337 0.0032854548501364 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.0546342218360011 0.0063560749071577 0.037538595103497 0.1700618733952761 +Metallopeptidase activity 14 41 2.9249300091839148 0.003445337041724 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.326192706464958 0.0001144472789083 0.000120926001959 5.681648836188599e-06 +Palmitoyl protein hydrolase activity 2 5 2.745692796216572 0.0060383276520195 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0573151884822011 0.1094892401774078 0.0025675639060761 0.018020673376298 +Molecular transducer activity 7 31 2.736262911801808 0.0062141355831359 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.1323708772076377 0.0378049213506607 0.2809855947934208 0.8105609845648432 +Exogenous protein binding 2 14 2.730970566512907 0.0063148111093231 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0204019662414969 0.0091243340822671 0.0931972749461429 0.3744563663843071 +Amide binding 18 98 2.726541631903042 0.0064001878179651 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 0.0032478194797668 0.0008043062234573 0.000130676317857 0.0004185835525766 +Serine type carboxypeptidase activity 4 5 2.702886781447556 0.0068740156344986 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 0.0002334823336694 3.9836639152197847e-08 1.5965763223642982e-06 2.6454681464607386e-07 +Monocarboxylic acid binding 5 19 2.671585098913274 0.007549392755662 5.274271844660194 16.905339805825243 -1.499852934083699 0.2065496077735153 1.9093582014997763 1.630495377421885 1.3571743846352866 0.2736855335695264 0.1747599807978781 0.0538434207197609 0.0138407349238781 0.0105883475769395 +Endopeptidase activity 18 58 2.648826732026035 0.0080771730864164 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 1.0 0.0052178109018932 0.0187000959352266 0.0028710917511246 +Protein transmembrane transporter activity 3 12 2.638816770746068 0.0083195933707478 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 7.189730386960826e-05 0.0005309775927247 0.0006049883657283 0.0010053263520343 +Metalloexopeptidase activity 5 21 2.623177491861872 0.0087113876689548 5.395631067961165 20.067961165048544 0.9825976981990544 0.3457114951896768 2.1791777953827336 1.4039620491256346 0.996651753778752 0.2995335114577974 0.1583124314184509 0.0003343305987075 0.0001637369749933 0.0002147363626889 +Transferase activity transferring one carbon groups 25 57 2.5672405121745268 0.0102511482271785 15.330097087378642 60.89320388349515 -0.0477714165453824 0.6328340990686153 8.505438978887788 9.11113968909267 0.8654901708448212 0.3212092574275675 1.0 0.5309522077521716 0.2815406504972733 0.0638414521442461 +Hydrolase activity acting on ester bonds 25 162 2.5584801247476374 0.0105130829587323 32.30825242718446 170.5995145631068 -0.3137126550979784 0.6673492259664346 14.468735287836472 18.191332080723143 0.7866273779959065 0.3355586504450551 0.0112535977990551 0.1140087027387602 0.0011445944492337 0.076044955506378 +Macromolecule transmembrane transporter activity 5 13 2.550599957925475 0.0107537681660137 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0001192904084611 0.0008717411361388 0.0011637071015076 0.0002747300414667 +Scavenger receptor activity 2 5 2.5462326802137434 0.0108892578210628 2.128640776699029 4.245145631067961 0.8895147156183107 0.1752904943890176 1.2029313295363038 0.9324780265795692 1.5451274177295422 0.2106852326062687 0.0015075035399645 0.0056684159955205 0.0025675639060761 0.018020673376298 +Metalloaminopeptidase activity 3 12 2.545445806964557 0.0109138303041074 2.9635922330097086 11.638349514563108 0.76408267919638 0.3753125793491905 1.6253856028641098 0.991608086033072 0.9139565265319636 0.2703249940924116 0.0756950383436983 0.0100519320580488 0.0004714775801565 0.0062633876942655 +Fad binding 4 10 2.532815479885992 0.0113150498419223 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.007105321595433 0.0255840399150975 0.0003345965146668 0.0074494564855197 +Carboxypeptidase activity 5 12 2.51831242862852 0.0117918671798376 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 0.0060718409625537 7.357256485958134e-05 0.0023669228385379 0.0008083265510004 +Thiolester hydrolase activity 3 14 2.504925559375604 0.0122477167644381 3.5388349514563107 15.259708737864075 0.4632661556505638 0.4260334035866009 2.4217755265330267 1.4839032472520584 1.039719510457206 0.2990167148437984 0.141543756104335 0.2590666885683055 0.0061462663837818 0.0157766780310383 +Serine hydrolase activity 8 18 2.4860742823320727 0.012916100230532 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.0230307909850112 9.137815410524424e-05 0.000134828763291 0.0004290006789134 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 1 5 2.439447738500053 0.0147097301808178 1.7839805825242718 5.402912621359223 0.124333058746836 0.3914974509468271 1.6038290588801534 0.6951924104236209 1.2069109191912994 0.2922321894579511 1.0 1.0 0.0323840811666381 0.1125747569923622 +Sterol transporter activity 3 9 2.4390487487144403 0.0147259815717317 2.621359223300971 8.364077669902912 0.5454888897585024 0.2973249899153176 1.425267849835305 1.6080715320593837 1.318674977748992 0.2709274408896192 0.0055832614279084 6.176416462866221e-05 0.0020099112654694 0.0042957165481444 +Cargo receptor activity 3 8 2.4328221984077323 0.0149816556591362 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.0082126449787597 0.0023694947377154 0.0042306660622233 0.0446088038944012 +Protein methyltransferase activity 12 28 2.392939937270686 0.0167139769466215 6.014563106796117 26.026699029126213 0.4409399615077188 0.5320867344352032 3.687394106216641 3.742535065332291 0.9403351080372092 0.3355341604352824 1.0 0.1897338295109766 0.1388871985844639 0.0477335517051887 +Monooxygenase activity 4 8 2.390127290798265 0.0168425342587525 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 1.0 0.0274603336438859 0.0036949558723267 0.008785557350241 +Dna polymerase activity 6 9 2.303949011890624 0.021225505962507 3.599514563106796 9.856796116504857 -0.0870956022486368 0.6209196333214555 2.312334960215435 1.5583715134606066 0.7431559902486617 0.2773525096433673 0.1330370821365251 0.2445730022705269 0.0316151554384263 0.0023211498250519 +Phosphoric ester hydrolase activity 10 56 2.302602444238398 0.0213012215148853 13.983009708737864 63.310679611650485 0.0419549724534753 0.6140737111070494 7.163296596269021 9.21904858538458 0.8993707212934827 0.3266109107762958 0.123613049261554 0.2196755626061812 0.0793566502209948 0.4402076577504455 +Peptide binding 10 68 2.3018482620881624 0.0213437307724937 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.0057124733176429 0.000519616476736 0.0028522382284012 0.012044722220628 +Zinc ion binding 32 130 2.291230251871596 0.0219501001662343 28.59223300970874 139.68203883495147 -0.0405402661254739 0.6975438866599186 14.186474409757915 17.65179293730256 0.7773657878061386 0.3244829078143309 0.2363083857932047 0.1140087027387602 0.020030403381554 0.1084925713390393 +Signaling receptor regulator activity 6 18 2.28809510438161 0.0221319832881097 4.072815533980583 17.339805825242717 0.7311308082630681 0.4520633016494398 2.421493327854957 2.496807274147909 0.9157780911218903 0.317372323464707 0.0496758524768897 0.0052630916622981 0.0307925237330937 0.0631907450454829 +Serine type exopeptidase activity 3 7 2.286472325368217 0.0222266413561129 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 0.0008300469730069 9.745982190989103e-07 3.72798665310574e-05 2.8311070051942505e-05 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 3 5 2.277889266890829 0.0227331759223781 1.5048543689320388 4.490291262135922 0.278788560706552 0.5101874933406457 1.0180295683783271 0.9176811810851436 0.921984521977564 0.2894246869117938 1.0 1.0 0.0111508905617615 0.0034377129995212 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 7 12 2.276631001099652 0.0228082700048415 3.8398058252427183 12.78883495145631 0.8288316105774708 0.2715528044153261 1.786836430207192 1.277729935586139 1.1940635938633195 0.228034100916913 0.0001834080308804 0.0013262573806951 0.0001815389677784 7.568702219565374e-05 +Nucleotidase activity 1 5 2.261685038520936 0.0237168697616914 1.900485436893204 6.160194174757281 0.4966413438555779 0.4635466099877495 1.3374006658627218 1.094366847655584 0.9498877141797232 0.303739625411128 0.0573151884822011 0.1094892401774078 0.0323840811666381 0.018020673376298 +Tetrapyrrole binding 5 15 2.26051552469099 0.0237892740154666 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.2336798458054532 0.0149914480702132 0.0093310290543298 0.0457670040656382 +Oxidoreductase activity acting on the ch ch group of donors 14 27 2.2539823482063883 0.0241972784725514 7.567961165048544 28.033980582524272 0.602739632464327 0.3658961640745555 3.3714596992024415 2.798024733162656 1.2394975779858992 0.2994161584769358 0.0017444833819082 0.0115248505447769 1.907485071840189e-05 1.7163900968398735e-05 +Oxidoreductase activity 58 222 2.252195724921753 0.0243099060690792 52.54126213592233 227.42961165048544 0.490492706528076 0.5955656171597654 20.033606385640603 16.688970744458114 1.2909283370539455 0.4039853598071011 0.027996741015638 0.0390991013877605 1.0188139143613432e-05 2.3615819426453573e-06 +Ion transmembrane transporter activity 19 92 2.23686605438671 0.0252950957647686 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 0.1940093225463129 0.1778047539529303 0.0033096355555559 0.0160472502450774 +Fatty acid binding 2 10 2.2152353599889376 0.0267439140106642 2.313106796116505 8.240291262135923 -0.0607820781776598 0.5562999429831071 1.5221736687759966 1.4822666690825792 0.9067280493676612 0.2991394972625407 1.0 0.1837383274168749 0.0132372029803992 0.0790607116166092 +Aminopeptidase activity 3 15 2.171145105460995 0.029920205370308 3.5776699029126213 14.45631067961165 0.6007185097241242 0.4145729618819276 2.0659717400878788 1.0453475199467217 0.9473217510139031 0.2770948009370171 0.1157751708195439 0.0237627189197599 0.0027652692158518 0.0308662830144804 +Catalytic activity acting on dna 23 85 2.168884791960947 0.030091431623078 26.00242718446602 85.75 -0.3500608277779486 0.5919299439851401 12.582639216108683 9.385649291410756 0.931241404473262 0.3350047723683129 0.6440859247507438 0.8686198190791818 0.0635952248117071 0.0059684921076351 +Sphingolipid binding 3 5 2.119200915271285 0.0340734909847557 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0847528009868792 0.1596960736798767 0.0085625102176751 0.0097510399506001 +Dna directed dna polymerase activity 5 7 2.1016762364931 0.0355816465987348 2.9199029126213594 7.495145631067961 0.1147726318284263 0.586152160764852 2.064703836467016 1.4287192065009142 0.8321595329711028 0.2979673720697421 0.1070183553885475 0.1993869387044997 0.1046379555654025 0.0042957165481444 +Phospholipid binding 19 83 2.0799507855949115 0.0375300471520949 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.0599945491514207 0.1650643812232873 0.111845426200506 0.29861106729011 +O acyltransferase activity 6 14 2.078822948979549 0.037633626765497 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.1457663642848915 0.266209970857853 0.0407347123090255 0.0007105677029561 +C acyltransferase activity 2 11 2.078676765512714 0.0376470699281088 3.754854368932039 10.57766990291262 -0.1925493966773774 0.5134389449480119 2.509322565170358 0.7315938231723079 0.9617710308168496 0.2943503822027815 0.0573151884822011 0.1094892401774078 0.0323840811666381 0.018020673376298 +Phosphatidylserine binding 3 10 2.0757726674498924 0.0379149814260491 2.029126213592233 10.060679611650484 0.6615116985008255 0.3340719518205703 1.5854698894895154 0.9597266622759548 1.1646704221215245 0.2873190862432436 0.0082126449787597 0.0293903981750984 0.0288428745821564 0.0446088038944012 +Modified amino acid binding 5 20 2.074227678481665 0.0380581708169969 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 0.0230307909850112 0.0775813155228076 0.0277204467011949 0.0079620077053278 +Epoxide hydrolase activity 2 5 2.05381636357558 0.0399934685608274 1.1019417475728157 4.521844660194175 0.5286018285197666 0.3719344719688537 1.0354381449156973 0.6208422834489354 1.1335270265758153 0.2772966130846634 0.0242848323540905 0.0471521402185075 0.1145296834007133 0.2203285200495684 +Ether hydrolase activity 2 5 2.05381636357558 0.0399934685608274 1.1019417475728157 4.521844660194175 0.5286018285197666 0.3719344719688537 1.0354381449156973 0.6208422834489354 1.1335270265758153 0.2772966130846634 0.0242848323540905 0.0471521402185075 0.1145296834007133 0.2203285200495684 +Histone methyltransferase activity 11 21 2.0238523987571364 0.0429853409423197 5.097087378640777 18.237864077669904 0.1244895512019806 0.4941614121988424 3.313006328716042 3.142524385825145 1.057643161070896 0.3213310584694642 1.0 0.4014202890149608 0.3651865398778758 0.0423415641222214 +Acylglycerol o acyltransferase activity 4 7 2.01569105011095 0.0438322920712717 2.6601941747572817 6.820388349514563 0.8174935736497821 0.2734948556707107 1.708365471336677 1.514259678343348 1.2372108727630755 0.2654117957889352 0.0981765691424607 0.1837383274168749 0.0895680133917324 0.0028145739091465 +Hydrolase activity acting on ether bonds 1 7 2.0067966878485906 0.0447713156935589 1.733009708737864 6.473300970873787 0.442831885081079 0.3761322348666416 1.4402594392445152 0.6511869496520301 1.1243392396889562 0.2763300958015678 0.0385773062479974 0.002465796513642 0.0146338936924203 0.0542215392640632 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8e47763c3fc97a24e3f970f64029f2dc52b20a96 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 1353, + "title": "Average number of proteins per term", + "value": 16.251293422025128 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0df7fa2a1182de77072c3f2b380bd848c848aaaf --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..eb285ae4ab4a630c7f34fcc580e9d0a128db193a --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,442 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transporter activity 0.4992320636815743 4.818723078883899 1.444799214711523e-06 0.001952905343692 0.000205113101904 157 P30536,P00403,Q99595,Q9BZF3,Q8TB61,Q8WTV0,Q14849,Q99797,O43681,Q8IXU6,O95298,Q6NT16,Q9NS69,Q9Y584,Q70HW3,Q93050,Q15043,P21796,O60830,O43772,Q9HD20,P41440,P51970,Q9UDW1,O15118,Q9Y5J9,P31930,P61916,Q9UBX3,P00846,Q9HC07,L0R6Q1,P45880,Q13423,P08183,Q9Y619,Q9H2D1 37 +5 3 exodeoxyribonuclease activity 0.9642620780939776 4.094804946947264 4.225239526145508e-05 0.0555652688471074 0.0006805653665327 2 Q8IV08 1 +Phospholipase d activity 0.952349437458637 4.040667548439278 5.329927025776726e-05 0.0695768855612962 0.0008158817683946 2 Q8IV08 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9523494374586376 4.040667548439278 5.329927025776726e-05 0.0695768855612962 0.0008158817683946 2 P30519 1 +Pattern recognition receptor activity 0.9437458636664476 4.0013402165341665 6.298472062749028e-05 0.0816906943462916 0.0009025426267836 2 Q8WTV0 1 +Low density lipoprotein particle binding 0.9437458636664476 4.0013402165341665 6.298472062749028e-05 0.0816906943462916 0.0009025426267836 2 Q8WTV0 1 +Amide transmembrane transporter activity 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.0879202055479419 0.0009025426267836 2 Q9H2D1 1 +Modified amino acid transmembrane transporter activity 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.0879202055479419 0.0009025426267836 2 Q9H2D1 1 +Folic acid transmembrane transporter activity 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.0879202055479419 0.0009025426267836 2 Q9H2D1 1 +Xenobiotic transmembrane transporter activity 0.9397749834546664 3.983123887000454 6.801527652244843e-05 0.0879202055479419 0.0009025426267836 2 P08183 1 +Neurotrophin binding 0.9364659166115166 3.967911899979936 7.250512584100477e-05 0.0934444688318636 0.0009168171519895 2 Q99523 1 +Chloride ion binding 0.920251489080081 3.8929518966127734 9.903179465187152e-05 0.1254070083469957 0.0011073555220163 2 Q96DE0 1 +Ganglioside binding 0.9070152217074808 3.8312334078375176 0.0001275024772735 0.1584600994285431 0.0013477410293056 2 P07602 1 +Glycosphingolipid binding 0.9070152217074808 3.8312334078375176 0.0001275024772735 0.1584600994285431 0.0013477410293056 2 P07602 1 +Deoxynucleoside kinase activity 0.8838517538054288 3.7220589610698247 0.0001976048641891 0.2346222686025077 0.0019245551820951 2 P55263 1 +Calmodulin dependent protein kinase activity 0.8825281270681699 3.715774770667619 0.0002025819808015 0.2397600614954804 0.0019439249647131 2 Q13555 1 +Lipid binding 0.438949548304795 3.699925415235873 0.0002156628399712 0.2530994918934758 0.0020263321005628 134 P30536,A6NIH7,Q9BZF3,P11717,P63167,Q8WTV0,Q14108,Q14849,Q8NCC3,Q9NZJ7,O75131,P21796,P07737,Q9BQE5,P07602,O15118,Q8IYI6,Q96T51,O95218,P11182,O95425,P50897,Q06481,P61916,Q9Y4G8,Q9Y5X1,P45880,Q13045,Q15067,P09429,Q96L92,O14735,Q9NV70,O15254 34 +Diacylglycerol binding 0.8762409000661839 3.685856510094548 0.0002279347555964 0.2654012716790653 0.0020979300974286 2 Q9Y4G8 1 +High density lipoprotein particle binding 0.9457424843997282 3.597427956974445 0.0003213794708114 0.3526682152970941 0.0027695950573751 3 Q8WTV0 1 +Sulfotransferase activity 0.8444738583719423 3.5329320680010814 0.000410978059836 0.4265976396499838 0.0033536079170775 2 Q7LGA3 1 +Fatty acid synthase activity 0.8408338848444744 3.5152183907261008 0.0004393924913932 0.4482325943684415 0.0033536079170775 2 Q8IVS2 1 +Inositol phosphate phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Phosphatidylinositol trisphosphate phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Phosphatidylinositol phosphate 5 phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Inositol polyphosphate 5 phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Inositol trisphosphate phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Phosphatidylinositol 4 5 bisphosphate phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity 0.8405029781601611 3.5136060763904333 0.0004420678651815 0.4502271383648121 0.0033536079170775 2 Q10713 1 +Peptidase activity 0.4596279526617479 3.5010417129332017 0.0004634432991934 0.4659063747344164 0.0034452680429052 108 P60900,O15484,P50579,Q99797,P42785,Q99538,P49773,P55786,Q92542,P67812,Q86UV5,Q9HB40,O43847,Q5JRX3,P36551,P49721,Q86TI2,P28074,P20618,P48147,O75976,P42892,Q7L5N1,P22695,Q9NZ08,P10619,Q96DE0,Q9H3G5,O75844,Q6P2Q9,Q9UIQ6,P53634,Q9Y5K5,Q10713 34 +Polysome binding 0.8371939113170123 3.4974647227161872 0.0004697028292108 0.4704126839008969 0.0034727209176083 2 P16989 1 +Phosphatidylinositol 3 5 bisphosphate phosphatase activity 0.831899404367969 3.4715694097372687 0.0005174255493083 0.5035427736291874 0.0037841987471036 2 Q01968 1 +Galactosidase activity 0.8176704169424265 3.401549693431156 0.0006700494527274 0.5962182504835091 0.0046730768532999 2 P16278 1 +Galactoside binding 0.8176704169424265 3.401549693431156 0.0006700494527274 0.5962182504835091 0.0046730768532999 2 P16278 1 +Arylsulfatase activity 0.8173395102581111 3.3999138725344857 0.0006740708182622 0.5984106932623482 0.0046770144467116 2 O43681 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.8962126542722708 3.3762937922379894 0.0007346942166481 0.6300571009941207 0.0049209964115098 3 Q16850 1 +Acyl coa oxidase activity 0.8927323054927275 3.3605200351024456 0.0007779588808727 0.6511063076524536 0.0051596978716706 3 O15254 1 +Oxidoreductase activity acting on the ch nh2 group of donors 0.8077432164129733 3.3523260579005636 0.0008013557966162 0.6619863682892244 0.0052632737515618 2 P23378 1 +Exopeptidase activity 0.6504100485287376 3.33735331509955 0.000845803541458 0.6817303888740345 0.0055017893826572 33 Q9HB40,Q9UIQ6,P42785,Q9NZ08,P10619,Q96DE0,P55786,Q9H3G5,O75844 9 +Steroid binding 0.7434316866711411 3.2517083976307912 0.0011471364573627 0.7883807330426897 0.0068591886127217 21 P30536,Q9BZF3,P45880,Q14108,P61916,O15118,P21796 7 +Sterol binding 0.8144105732907082 3.2217006247979136 0.0012743221065969 0.8218727881458978 0.0072443605471666 16 P30536,Q9BZF3,P45880,Q14108,P61916,O15118,P21796 7 +Histone methyltransferase activity h3 k9 specific 0.7809397749834571 3.217857384745465 0.0012915201744918 0.8259749782757531 0.0073042593157791 2 Q96KQ7 1 +Structural constituent of eye lens 0.8570009930486544 3.19672696713629 0.0013899642603019 0.8477040870570649 0.0076448034316605 3 P08670,Q99797 2 +Cholesterol binding 0.8418325841973521 3.158453206150752 0.0015860877024247 0.8832453222256726 0.0083177389975995 13 P30536,Q9BZF3,P45880,Q14108,P61916,O15118,P21796 7 +Alcohol binding 0.7969748599656811 3.1283957179853714 0.0017576336854612 0.9074652217308784 0.0091114114039426 16 P30536,Q9BZF3,P45880,Q14108,P61916,O15118,P21796 7 +Phosphatidylinositol bisphosphate phosphatase activity 0.8321747765640539 3.0808875739855113 0.0020638455980575 0.938901538232577 0.0104535743404526 3 Q01968,Q10713 2 +Transition metal ion binding 0.3781002251351938 3.0690728099859323 0.0021472425240078 0.9454339133155232 0.0106167713530086 180 P00403,Q8N4Q0,P26358,Q8NCC3,Q9BU89,P22830,Q9UHD1,P55786,Q96KQ7,P00813,Q10472,Q5JRX3,P36551,Q15800,P19474,Q8N8N7,P05067,Q9NVH6,P09874,Q15428,O75976,P32321,Q16850,P42892,Q9NZ08,Q06481,Q9Y5J9,O60888,P09884,Q96DE0,Q99536,Q9NUD5,Q9H6W3,Q9Y6X9,P04183,Q5VT66,O43823,O95487,Q9UIQ6,Q8IWV8,O14735,Q9NWV4,Q9Y5L4,Q9UIG0 44 +Protein lipid complex binding 0.9090798675829844 3.0686847353068876 0.0021500335186432 0.9456400200826036 0.0106167713530086 4 Q8WTV0,Q9BQE5 2 +Ceramide binding 0.907615894039732 3.062347582024693 0.0021960828377531 0.948930481906297 0.0107655799981161 4 P45880,P07602,P21796 3 +Protein tyrosine kinase inhibitor activity 0.8268785170473362 3.0559537616108594 0.0022434585032566 0.9521081220815892 0.0108981817914687 3 O95684,Q86XI2 2 +O acetyltransferase activity 0.7491727332892157 3.0554411634448604 0.0022472969104359 0.9523567541742968 0.0108981817914687 2 O15228 1 +Organic cation transmembrane transporter activity 0.8989179190871933 3.0245919982327067 0.0024896873907591 0.9657047125813738 0.0114100169632204 4 Q70HW3 1 +Sulfuric ester hydrolase activity 0.8176100628930655 3.012129555119806 0.0025942185386367 0.9702384621929891 0.0117784485999177 3 O43681,P15586 2 +Phosphotransferase activity nitrogenous group as acceptor 0.8137019669521686 2.9935778659456935 0.0027572714130397 0.9761445080461524 0.0124352940728091 3 P12532 1 +Sterol transfer activity 0.890074605860321 2.9860212764823504 0.002826329779382 0.9782781882206916 0.0126623317599466 4 P30536,P61916 2 +Mitochondrion targeting sequence binding 0.8110647220164684 2.981034299585265 0.0028727661488572 0.9796046087798056 0.0127774414770234 3 Q9Y584 1 +Protein transporter activity 0.7774331985325598 2.953241420216779 0.0031445593218746 0.9858959349610488 0.0135929353434388 15 Q99595,O60830,Q9Y5J9,Q9HD20,Q9NS69 5 +Lipid transporter activity 0.7622867434987176 2.9396855527277337 0.0032854548501364 0.9883510441716 0.013804461117792 16 P30536,P61916,Q9BZF3,O15118 4 +Metallopeptidase activity 0.5685613308440124 2.9249300091839148 0.003445337041724 0.9906238851786552 0.0142120152971115 41 O75976,P50579,Q9UIQ6,Q5JRX3,Q99797,P42892,Q7L5N1,Q9NZ08,P36551,P22695,Q96DE0,P55786,Q10713,O75844 14 +Tap binding 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.9940588122960684 0.0154100868087063 3 P10321 1 +Histone arginine n methyltransferase activity 0.7864528423282287 2.863006910933997 0.0041964141025503 0.9966193754405436 0.0168479177470344 3 Q86X55 1 +Peptide antigen binding 0.851847206382834 2.817115591057501 0.0048457082562354 0.9986012546104333 0.0191144118678907 4 Q15392,P10321 2 +Sulfur compound transmembrane transporter activity 0.848725900993585 2.8031660427842033 0.0050603609329993 0.9989553259049858 0.0198454154850669 4 Q9UBX3,Q70HW3 2 +K63 linked polyubiquitin modification dependent protein binding 0.7680316709424435 2.773509294138774 0.0055455256282119 0.9994600196004704 0.0214374176427737 3 Q9Y6K9 1 +Vitamin d binding 0.6949040370615536 2.769980218509982 0.0056059697222385 0.999502650282138 0.0215479461198545 2 P38435 1 +Solute proton symporter activity 0.6925876902713484 2.757563943761268 0.0058233822505917 0.999630021980056 0.0223037741310107 2 Q9H936 1 +Palmitoyl protein hydrolase activity 0.9038447912352336 2.745692796216572 0.0060383276520195 0.9997238656947898 0.0229490373965797 5 Q9NUJ1,Q9UMR5 2 +Molecular transducer activity 0.5841946006486802 2.7362629118018074 0.0062141355831359 0.999782640424668 0.0235510516638179 31 P30536,Q8WTV0,Q99523,Q14108,Q99720,P10586,O15118 7 +Exogenous protein binding 0.7478985184105628 2.730970566512907 0.0063148111093231 0.999810482695648 0.0238657526003192 14 Q8WTV0,Q14108 2 +Amide binding 0.4156919119003433 2.726541631903042 0.0064001878179651 0.9998312823570225 0.023868874635403 98 P10321,P50542,Q8WTV0,P45880,Q9NZJ7,Q15392,P24390,P42892,Q9UIQ6,Q9NZ08,P07602,P40939,P04818,Q13427,P41440,Q9Y584,P55786,P21796 18 +Manganese ion transmembrane transporter activity 0.8309687646757185 2.7233451619220435 0.006462450078575 0.9998449976247796 0.0238898769298143 4 Q9HD20,Q15043 2 +Transition metal ion transmembrane transporter activity 0.8309687646757185 2.7233451619220435 0.006462450078575 0.9998449976247796 0.0238898769298143 4 Q9HD20,Q15043 2 +Nucleotide phosphatase activity acting on free nucleotides 0.757206602207521 2.7204467115453146 0.0065193778710326 0.9998565604173651 0.0239693430964868 3 Q96DE0 1 +Serine type carboxypeptidase activity 0.8936734017886758 2.702886781447556 0.0068740156344986 0.9999115131356549 0.0251366031175044 5 P42785,Q9HB40,P10619,Q9H3G5 4 +Polypeptide n acetylgalactosaminyltransferase activity 0.7521381651984695 2.695481431105871 0.0070286995263286 0.9999283278825 0.0254638556992665 3 Q10472 1 +Acetylgalactosaminyltransferase activity 0.7521381651984695 2.695481431105871 0.0070286995263286 0.9999283278825 0.0254638556992665 3 Q10472 1 +Histone h3 methyl lysine 9 demethylase activity 0.681005956320323 2.6951913337805955 0.0070348222438239 0.9999289233342296 0.0254638556992665 2 Q7LBC6 1 +Voltage gated anion channel activity 0.8220254639953248 2.6828441677419743 0.007299899638637 0.999950472887468 0.0260600638814669 4 P45880 1 +Monocarboxylic acid binding 0.6771001435717144 2.671585098913274 0.007549392755662 0.9999647512165636 0.0268383276126458 19 P11717,P11182,Q15067,P07602,O15254 5 +17 beta hydroxysteroid dehydrogenase nadpplus activity 0.6733951025810776 2.6539377096196164 0.0079558511863051 0.9999797491660154 0.02788670117894 2 Q53GQ0 1 +Endopeptidase activity 0.4667839140107489 2.648826732026035 0.0080771730864164 0.9999828376005356 0.0280518185778813 58 P60900,P20618,O15484,P48147,Q5JRX3,Q99797,P42892,P22695,Q9NZ08,P53634,P49721,Q99538,O75844,P28074,Q92542,Q10713,P67812,Q86UV5 18 +Protein transmembrane transporter activity 0.7515296897566616 2.6388167707460677 0.0083195933707478 0.9999876702503456 0.0286695035565107 12 Q9NS69,Q99595,O60830 3 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.7391592188017113 2.631198396486382 0.0085084350166102 0.9999904709576962 0.0289972609004374 3 O43169,Q5VT66 2 +Metalloexopeptidase activity 0.6426458238552905 2.6231774918618713 0.0087113876689548 0.9999927763200638 0.0295545901029337 21 Q9UIQ6,Q9NZ08,Q96DE0,P55786,O75844 5 +Peptidase activator activity involved in apoptotic process 0.7332009268454082 2.60151656146735 0.0092812583657235 0.9999966821068582 0.0310830261604554 3 P53634,P63244 2 +Protein arginine omega n asymmetric methyltransferase activity 0.732912380804443 2.6000763943350766 0.0093203009297258 0.999996854384828 0.0311367090318987 3 Q86X55 1 +Map kinase activity 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999972789250282 0.0313365863495884 2 P28482 1 +Transferase activity transferring one carbon groups 0.4601067782839603 2.5672405121745268 0.0102511482271785 0.9999991182734512 0.0335830594464226 57 Q03164,Q9BZ95,O96028,Q9BV44,P26358,Q86X55,Q15047,Q96KQ7,P34896,O75530,Q7Z2T5,P04818,Q08J23,Q14166,P27708,O60725,P34897,Q8NCA5,Q8N6R0,O43159,Q15022,Q7Z4G4,Q99873,Q5T280,Q9BV86 25 +Hydrolase activity acting on ester bonds 0.3611776222381094 2.5584801247476374 0.0105130829587323 0.999999383680018 0.0341927914499154 162 P15586,Q9NUJ1,Q8NHP8,Q5TFE4,Q8NCC3,Q969T7,P09601,O43681,Q9NPH0,Q9Y3B2,Q9H6V9,O94919,Q13555,Q15165,Q9BRJ7,P27695,P50897,Q96DE0,Q16775,Q8IV08,Q9Y4W2,Q9UQ84,Q9UMR5,Q10713,P10586 25 +Macromolecule transmembrane transporter activity 0.724980142848013 2.550599957925475 0.0107537681660137 0.9999995565348442 0.0346424960205155 13 Q99595,O60830,Q9Y584,P51991,Q9NS69 5 +Scavenger receptor activity 0.8568979535939552 2.5462326802137434 0.0108892578210628 0.9999996315532288 0.0347804185228326 5 Q8WTV0,Q14108 2 +Metalloaminopeptidase activity 0.7337693914402823 2.545445806964557 0.0109138303041074 0.999999643732002 0.0347804185228326 12 Q9NZ08,Q9UIQ6,P55786 3 +Fad binding 0.7983555539437138 2.532815479885992 0.0113150498419223 0.99999979423558 0.0355203304782387 10 O15254,O95831,Q15392,O00116 4 +Sumo transferase activity 0.6508934480476567 2.5307239620736746 0.0113827389973066 0.9999998124403005 0.0356284386311785 2 P49792 1 +Thioesterase binding 0.6499007279947118 2.5252448629998714 0.0115617699586261 0.9999998532020518 0.0358786118211494 2 P60953 1 +Heme transmembrane transporter activity 0.6495698213103969 2.5234176817318628 0.0116220267313265 0.9999998648245472 0.0359830713214754 2 O75027 1 +Carboxypeptidase activity 0.7286437516889634 2.51831242862852 0.0117918671798376 0.9999998928684624 0.0364255623157997 12 O75976,Q9HB40,P42785,P10619,Q9H3G5 5 +Thiolester hydrolase activity 0.7065061857718905 2.504925559375604 0.0122477167644381 0.9999999426146337 0.0375763283045007 14 Q9NUJ1,Q16775,Q9UMR5 3 +Dna translocase activity 0.6455989410986167 2.5014596976858083 0.0123682518865031 0.999999951348966 0.0377748189671303 2 Q2NKX8 1 +Serine hydrolase activity 0.6590509249621013 2.4860742823320727 0.012916100230532 0.9999999770356416 0.0390976835069479 18 P48147,O75976,Q9HB40,Q5JRX3,P42785,P10619,P53634,Q9H3G5 8 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 0.8322227590251955 2.4394477385000535 0.0147097301808178 0.999999998039556 0.0436935374266515 5 Q9UQ84 1 +Sterol transporter activity 0.8098178233413983 2.4390487487144403 0.0147259815717317 0.999999998082822 0.0436935374266515 9 P30536,Q9BZF3,O15118 3 +Cargo receptor activity 0.8383283309166963 2.4328221984077323 0.0149816556591362 0.9999999986505306 0.0442580351677103 8 Q8WTV0,O15260,Q14108 3 +Sulfatide binding 0.6977821913273653 2.4228286965281343 0.0154001867426347 0.9999999992406526 0.0452966362234453 3 P55145,P50897 2 +Rna dna hybrid ribonuclease activity 0.7649711356895916 2.4196624991069906 0.0155349180057737 0.9999999993690012 0.0454951170169089 4 Q9UQ84 1 +Metal ion proton antiporter activity 0.629384513567181 2.411186729173488 0.0159007052483803 0.9999999996183552 0.0463656340540057 2 Q92581 1 +Protein arginine omega n monomethyltransferase activity 0.628060886829921 2.403774051654091 0.0162267992551656 0.9999999997562647 0.0472147513811594 2 Q99873 1 +Protein methyltransferase activity 0.5593578570778488 2.392939937270686 0.0167139769466215 0.9999999998753024 0.0482175070549658 28 Q03164,Q9BZ95,O96028,Q15022,Q96KQ7,Q99873,Q8NCA5,Q86X55,O75530,Q14166,O60725,Q9BV86 12 +Monooxygenase activity 0.8286894078431688 2.390127290798265 0.0168425342587525 0.9999999998955208 0.0484849975576431 8 P09601,Q16850,Q15800,P30519 4 +Dynactin binding 0.6880812195651653 2.3732119465503816 0.0176341417650842 0.9999999999648664 0.0504418473745433 3 P43034 1 +Phosphatidylinositol phosphate phosphatase activity 0.7537612481887089 2.366966605280633 0.017934550990946 0.9999999999767724 0.0511929271956752 4 Q01968,Q10713 2 +Wide pore channel activity 0.7458752948130682 2.3297007696871472 0.0198219718436547 0.9999999999982796 0.0555261447297409 4 P45880 1 +Porin activity 0.7458752948130682 2.3297007696871472 0.0198219718436547 0.9999999999982796 0.0555261447297409 4 P45880 1 +Minus end directed microtubule motor activity 0.6118464592984851 2.312435288157407 0.0207537075917687 0.9999999999995248 0.0576586578473575 2 Q8NCM8 1 +Dna polymerase activity 0.7807535207335543 2.303949011890624 0.021225505962507 0.9999999999997524 0.0588485851788361 9 P28340,Q9NRG0,Q9NR33,P09884,Q9NRF9,Q15185 6 +Phosphoric ester hydrolase activity 0.4364784186869872 2.302602444238398 0.0213012215148853 0.9999999999997772 0.0589348321126204 56 Q9BRJ7,P27695,Q8IV08,Q13555,Q5TFE4,P09601,Q969T7,Q9NPH0,Q96DE0,P10586 10 +Peptide binding 0.4238299721438932 2.3018482620881624 0.0213437307724937 0.9999999999997898 0.0589348321126204 68 P50542,Q8WTV0,Q15392,P24390,P42892,Q9UIQ6,Q9NZ08,Q13427,Q9Y584,P55786 10 +Zinc ion binding 0.3534288548078171 2.2912302518715957 0.0219501001662343 0.9999999999999092 0.0601516736530349 130 Q03164,Q8N4Q0,P26358,Q8NCC3,Q9UHD1,P55786,Q96KQ7,P00813,Q5JRX3,P36551,P19474,Q8N8N7,P09874,Q15428,O75976,P32321,P42892,Q9NZ08,Q9Y5J9,P09884,Q99536,Q9NUD5,Q9Y6X9,P04183,O43823,O95487,Q04760,Q9UIQ6,Q8IWV8,Q9NWV4,Q9Y5L4,Q9UIG0 32 +Retromer complex binding 0.7377257825469257 2.2910200878507627 0.021962251873318 0.9999999999999106 0.0601516736530349 4 Q99523 1 +Vitamin transmembrane transporter activity 0.7373320359009892 2.289146859814095 0.0220708209426145 0.9999999999999232 0.0603269105764798 4 Q9H2D1 1 +Signaling receptor regulator activity 0.6267775493241995 2.28809510438161 0.0221319832881097 0.9999999999999294 0.060372123767767 18 P14174,Q86XI2,Q9UMX5,P43490,P05067,Q00535 6 +Serine type exopeptidase activity 0.8329007271410933 2.286472325368217 0.0222266413561129 0.999999999999938 0.060386838865102 7 P42785,Q9HB40,P10619 3 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.7954721117957717 2.277889266890829 0.0227331759223781 0.9999999999999692 0.0614787402885258 5 P36551,O15254,Q15067 3 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.6836686536550007 2.276631001099652 0.0228082700048415 0.9999999999999722 0.0614787402885258 12 P49327,Q8N4Q0,Q15392,Q14914,Q14739,Q8N8N7,Q9NZ01 7 +Proline rich region binding 0.7344065142375121 2.2752162838264076 0.022892958500341 0.9999999999999754 0.0614787402885258 4 Q9UQB8 1 +R smad binding 0.7343285758488174 2.274844858550836 0.02291523816409 0.999999999999976 0.0614787402885258 4 P09874 1 +Dipeptidyl peptidase activity 0.73428535032142 2.274638855043593 0.0229276032468161 0.9999999999999764 0.0614787402885258 4 P42785 1 +Long chain fatty acid binding 0.6042356055592399 2.269221814198342 0.0232548403482115 0.9999999999999852 0.0620587751304344 2 Q00169 1 +Nucleotidase activity 0.7918234276768759 2.261685038520936 0.0237168697616914 0.999999999999992 0.0629983689699869 5 Q969T7 1 +Tetrapyrrole binding 0.6533847424632369 2.26051552469099 0.0237892740154666 0.9999999999999928 0.0629983689699869 15 O43169,Q8WUJ1,Q16850,P09601,P30519 5 +Oxidoreductase activity acting on the ch ch group of donors 0.5424851163660697 2.2539823482063883 0.0241972784725514 0.999999999999996 0.0635435942264473 27 P49327,Q8N4Q0,Q15392,Q15067,O15254,P50336,P36551,Q92947,Q14914,Q6NUM9,Q14739,Q8N8N7,Q9UBM7,Q9NZ01 14 +Oxidoreductase activity 0.3020741290957581 2.2521957249217532 0.0243099060690792 0.9999999999999966 0.0635435942264473 222 P00403,P14406,Q8N4Q0,Q9BU89,P35270,P09601,O95298,Q14914,Q92947,O75251,Q9UHG3,P00390,Q8IZ83,O43169,O95831,Q15392,Q8NBX0,P09622,P50336,Q15800,P36551,P30519,P51970,Q8N8N7,Q96CU9,Q9UDW1,Q9NVH6,P27695,P20674,Q9Y6M9,O43488,P00367,O95864,Q16850,P40939,Q6NUM9,Q99497,P31930,Q99536,Q9NZ01,Q9H6W3,O14880,P08574,Q709F0,P49327,Q5VT66,P23378,Q06136,Q13423,Q15067,P30837,P30044,Q3SXM5,O00116,Q14739,Q9UBM7,O15254,Q6DKJ4 58 +Ion transmembrane transporter activity 0.3850287549545953 2.23686605438671 0.0252950957647686 0.9999999999999992 0.0656895673123454 92 P00403,Q8TB61,O43681,Q15043,P21796,Q70HW3,Q93050,O43772,Q9HD20,P41440,Q9UDW1,P31930,Q9UBX3,P00846,Q9HC07,P45880,Q13423,Q9Y619,Q9H2D1 19 +Fatty acid binding 0.7330992731837063 2.2152353599889376 0.0267439140106642 1.0 0.0690544191916578 10 O15254,P11182 2 +Aminopeptidase activity 0.6380555534869184 2.171145105460995 0.029920205370308 1.0 0.0755180029499551 15 Q9NZ08,Q9UIQ6,P55786 3 +Catalytic activity acting on dna 0.3790677874899726 2.168884791960947 0.030091431623078 1.0 0.0755180029499551 85 P26358,Q9H2U1,Q9Y2C4,Q9NRF9,P35250,P46063,Q66K74,P41440,Q15185,Q9H4L7,P27695,P33991,Q9NRG0,Q14566,Q9NR33,Q8N3C0,P09884,Q96QE3,Q8IV08,P28340,Q9UQ84,Q08211,Q07864 23 +Coreceptor activity 0.5866975512905441 2.1688180637984726 0.0300964992744992 1.0 0.0755180029499551 2 Q13308 1 +Fibronectin binding 0.586697551290544 2.1688180637984726 0.0300964992744992 1.0 0.0755180029499551 2 Q53GQ0 1 +Oxidoreductase activity acting on diphenols and related substances as donors 0.7096026490066137 2.156219508559222 0.0310665289205129 1.0 0.0772665691717905 4 P31930,P08574,Q9UDW1 3 +Ubiquinol cytochrome c reductase activity 0.7096026490066137 2.156219508559222 0.0310665289205129 1.0 0.0772665691717905 4 P31930,P08574,Q9UDW1 3 +Sphingolipid binding 0.7600215979412818 2.119200915271285 0.0340734909847557 1.0 0.0833660638379286 5 P45880,P07602,P21796 3 +Dna directed dna polymerase activity 0.7904617392758072 2.1016762364931 0.0355816465987348 1.0 0.0864308219893864 7 P28340,Q9NRG0,Q9NR33,P09884,Q9NRF9 5 +Transferrin receptor binding 0.6973509933774739 2.096860726389378 0.0360059060238229 1.0 0.0873046431007749 4 Q9Y6K9,Q13596,O15111 3 +Phospholipase binding 0.6958744212405503 2.0896810923448363 0.036646456581372 1.0 0.0885404567046362 4 P84103 1 +Phospholipid binding 0.3716841258086517 2.0799507855949115 0.0375300471520949 1.0 0.0901530718809403 83 Q8WTV0,Q14108,Q8NCC3,Q9NZJ7,O75131,P21796,P07737,P07602,Q8IYI6,O95425,P50897,Q06481,Q9Y5X1,Q9Y4G8,P45880,Q13045,P09429,Q96L92,Q9NV70 19 +O acyltransferase activity 0.6312216642764044 2.078822948979549 0.037633626765497 1.0 0.0901530718809403 14 Q6P1A2,Q9HCL2,Q8NCC3,Q6UWP7,Q96N66,Q9UKG9 6 +C acyltransferase activity 0.677207963199209 2.078676765512714 0.0376470699281088 1.0 0.0901530718809403 11 P40939,Q9BWD1 2 +Phosphatidylserine binding 0.7051452928790634 2.0757726674498924 0.0379149814260491 1.0 0.0905807078005996 10 Q8WTV0,Q14108,Q06481 3 +Modified amino acid binding 0.5713455237707787 2.074227678481665 0.0380581708169969 1.0 0.0905807078005996 20 Q8WTV0,Q14108,P04818,Q06481,P41440 5 +Solute proton antiporter activity 0.6295928500496475 2.067910755016624 0.038648415897396 1.0 0.0917391345775033 3 P51790,Q92581 2 +Epoxide hydrolase activity 0.7455912144167217 2.0538163635755797 0.0399934685608274 1.0 0.0944348393766134 5 O43488,P07099 2 +Ether hydrolase activity 0.7455912144167217 2.0538163635755797 0.0399934685608274 1.0 0.0944348393766134 5 O43488,P07099 2 +Racemase and epimerase activity 0.5628722700198634 2.03059694303572 0.0422958980906071 1.0 0.0976558875709752 2 Q8NCW5 1 +Histone methyltransferase activity 0.5527429710958413 2.0238523987571364 0.0429853409423197 1.0 0.0990786478619397 21 Q03164,Q9BZ95,O96028,Q15022,Q96KQ7,Q86X55,O75530,Q14166,Q15047,Q99873,Q9BV86 11 +Tau protein kinase activity 0.6821348392192143 2.0226117997014383 0.0431131866890377 1.0 0.0992043224324286 4 Q00535 1 +Acylglycerol o acyltransferase activity 0.7709962931255168 2.01569105011095 0.0438322920712717 1.0 0.1002256378864389 7 Q6UWP7,Q6P1A2,Q8NCC3,Q96N66 4 +Hydrolase activity acting on ether bonds 0.768992464415612 2.0067966878485906 0.0447713156935589 1.0 0.1019791079686621 7 P07099 1 +Protein disulfide reductase nad p activity 0.6765773788335605 1.995349882263902 0.0460047329889967 1.0 0.1044369190169675 4 Q6DKJ4 1 +Cytochrome b5 reductase activity acting on nad p h 0.6117179741807303 1.9725343506621575 0.0485486389493208 1.0 0.1083198786461353 3 Q9UHQ9,P00387 2 +Structural constituent of muscle 0.7815582675609722 1.9580392424620612 0.0502254081314992 1.0 0.1110375444475791 6 P09493,P67936 2 +Pre mirna binding 0.7237119437669457 1.9538302148440188 0.0507212997204655 1.0 0.1119509274417453 5 Q9H2U1,O75569 2 +Hormone binding 0.7563184048798526 1.950358555397322 0.0511333979738308 1.0 0.1126766896719758 7 P30536 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.5996470616127968 1.943670642856013 0.0519351809770594 1.0 0.1140719153603269 15 Q9BRJ7,Q9UQ84,Q96DE0 3 +Hydroxymethyl formyl and related transferase activity 0.6645135232681176 1.9359111455403255 0.0528785844517585 1.0 0.1159557937815709 4 P34896 1 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.5872360012707653 1.9213506880119584 0.0546875108702791 1.0 0.1195350601090269 16 Q9BRJ7,Q9UQ84,Q96DE0 3 +Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor 0.7694024264104505 1.9057306702032664 0.0566851579430447 1.0 0.1231324683303895 6 P09622,Q6DKJ4 2 +Atpase regulator activity 0.7684223392128704 1.9015017829509808 0.0572363191896432 1.0 0.1233740205189553 6 O95429 1 +Adenyl nucleotide exchange factor activity 0.7684223392128704 1.9015017829509808 0.0572363191896432 1.0 0.1233740205189553 6 O95429 1 +Single stranded dna exodeoxyribonuclease activity 0.7123009459918995 1.9012863796698771 0.0572645121107937 1.0 0.1233740205189553 5 Q8IV08 1 +U3 snorna binding 0.665904641543944 1.876670300793156 0.0605632955455537 1.0 0.1287446428488747 10 P55769,P78527 2 +5 3 exonuclease activity 0.7133245286362764 1.863198389548105 0.0624343593883311 1.0 0.1315789536641933 8 Q8IV08 1 +2 acylglycerol 3 phosphate o acyltransferase activity 0.6488199806680923 1.8580683660092032 0.0631593064185251 1.0 0.1325853307486224 4 Q6P1A2 1 +Microtubule minus end binding 0.7025809149305773 1.8563206456137176 0.0634078680501724 1.0 0.1328031663651443 5 Q9H6D7 1 +C acetyltransferase activity 0.7331325024132037 1.8463169132928337 0.064846203363972 1.0 0.1351878476909926 7 Q9BWD1 1 +Dna apurinic or apyrimidinic site endonuclease activity 0.5860379591142221 1.833893486573786 0.0666698066285671 1.0 0.1381382057709821 3 P27695 1 +Alpha glucosidase activity 0.5833083510039128 1.819049061202648 0.0689039454449278 1.0 0.1416595792743636 3 P35573 1 +Lipid transfer activity 0.726420602455063 1.816013476615101 0.0693683048699724 1.0 0.1422050249834436 7 P30536,P61916 2 +Flavin adenine dinucleotide binding 0.4901819625640232 1.8129550031430857 0.0698387617075912 1.0 0.1426326062432969 26 O95831,Q15392,P09622,O00116,O15254 5 +Scaffold protein binding 0.5596584088980481 1.8047611971967823 0.0711120588179199 1.0 0.1449015294889241 17 Q9UQB8,Q9NZJ7,P08670,P07602 4 +Microfilament motor activity 0.6740880554300575 1.790972714764206 0.0732976736413388 1.0 0.1489065351902875 9 Q9Y4I1,P35580,P60660 3 +Phosphatase activity 0.4263042917975711 1.7586790357543554 0.0786320401531115 1.0 0.1585289977227916 45 Q9BRJ7,Q13555,Q5TFE4,Q969T7,Q9NPH0,Q96DE0,P10586 7 +Acetyl coa c acetyltransferase activity 0.7345583230775845 1.7543789011514197 0.0793656041553818 1.0 0.1595567049364512 6 Q9BWD1 1 +Mismatch repair complex binding 0.5706436099089283 1.7499158584106485 0.0801328338180784 1.0 0.1606218135642372 3 P52701 1 +Mutlalpha complex binding 0.5706436099089283 1.7499158584106485 0.0801328338180784 1.0 0.1606218135642372 3 P52701 1 +Metalloendopeptidase activity 0.5732007280664609 1.7377823180367735 0.0822491774456655 1.0 0.1641344204778546 14 P42892,Q99797,P22695,Q5JRX3,Q10713,O75844 6 +Abc type transporter activity 0.6756186120371355 1.7306323410675315 0.0835173596349831 1.0 0.166419716621697 5 Q9HD20 1 +Glycolipid binding 0.6848895969272565 1.7290653244637022 0.0837974043249136 1.0 0.1667321883111885 8 P07602,Q9NZJ7,P50897 3 +Cation transmembrane transporter activity 0.3771005882889688 1.7224311025925032 0.0849914535144573 1.0 0.1686120771335202 67 P00846,P00403,Q9HC07,O43772,Q13423,Q9HD20,Q9UDW1,P31930,Q70HW3,Q9Y619,Q00535,Q15043,Q93050 13 +Exodeoxyribonuclease activity 0.6063155047395183 1.6980096822299573 0.0895059344407398 1.0 0.1762037333309231 11 P27695,Q8IV08,Q9UQ84,P28340 4 +Acetyl coa c acyltransferase activity 0.6780365559695852 1.6965167165017048 0.0897880671274089 1.0 0.1763182218046216 8 Q9BWD1 1 +Non membrane spanning protein tyrosine kinase activity 0.6157702207904392 1.692320662669273 0.0905848502073931 1.0 0.1771117085702354 4 Q9UIG0 1 +Cullin family protein binding 0.6154702144107373 1.690805532530912 0.0908739501883002 1.0 0.1774205694152528 4 P63208,Q9BTE7 2 +Voltage gated channel activity 0.6951012309165643 1.673581436443807 0.0942128893630469 1.0 0.1828838440576793 7 P45880,P21796 2 +N methyltransferase activity 0.4832094414236236 1.6708881773656463 0.0947437671604538 1.0 0.1833881501689471 24 Q03164,Q9BZ95,O96028,O43148,Q96KQ7,Q86X55,Q7Z2T5,P61964,Q14166,Q7Z4G4,Q15047,Q99873 12 +Dolichyl phosphate mannose protein mannosyltransferase activity 0.5013236267372709 1.6643717707886116 0.0960381577779623 1.0 0.1848358854531764 2 Q6ZXV5 1 +Protein arginine n methyltransferase activity 0.6594437775897763 1.6545988847264992 0.0980058899016271 1.0 0.1881229416757086 5 Q86X55 1 +Threonine type peptidase activity 0.666396318018264 1.6410484958800653 0.1007873487543384 1.0 0.1923226006978554 8 P28074,P49721 2 +Threonine type endopeptidase activity 0.666396318018264 1.6410484958800653 0.1007873487543384 1.0 0.1923226006978554 8 P28074,P49721 2 +Deaminase activity 0.6559882877192339 1.6382986397369816 0.1013594113123561 1.0 0.1928469591192804 5 P00813 1 +Metallocarboxypeptidase activity 0.60497772804079 1.6377042861414666 0.1014833960775518 1.0 0.1928469591192804 4 O75976 1 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines 0.6852417248641778 1.6284164057432091 0.1034366212858184 1.0 0.1957339141254718 7 P00813 1 +H4 histone acetyltransferase activity 0.5482862526129182 1.6268961662343957 0.1037591523602854 1.0 0.1960700183567963 3 Q86UY6 1 +Lysophospholipid acyltransferase activity 0.703506493426719 1.617879921452279 0.1056884781679161 1.0 0.1988824909056892 6 Q6UWP7,Q6P1A2,Q96N66 3 +Phosphatidylglycerol binding 0.5458559454186465 1.613453880507725 0.1066459353157547 1.0 0.2004054867808557 3 O60313 1 +Nucleoside kinase activity 0.545326538546969 1.6105239737820904 0.1072835160657961 1.0 0.2010451485277315 3 P55263 1 +Antigen binding 0.7013293986036577 1.6082582495723972 0.1077786304615973 1.0 0.2016936196604995 6 P10321,Q15392 2 +Organic acid transmembrane transporter activity 0.5287516463942372 1.607562042686359 0.1079311309847543 1.0 0.2017000279314539 17 Q9H2D1,Q9UBX3,P08183,P41440 4 +Pdz domain binding 0.5421564752039895 1.5945451987931416 0.1108139756542996 1.0 0.2065149530220503 15 Q9UQB8,Q9Y4G8 2 +Cyclic nucleotide binding 0.6465150131353479 1.5935146259172852 0.1110447898759252 1.0 0.2065149530220503 5 Q9Y4G8 1 +Nucleobase containing compound transmembrane transporter activity 0.5545330900970431 1.585467118376103 0.1128602420554203 1.0 0.2080380211185064 13 L0R6Q1,Q8TB61,Q9BSK2,P51991,P41440,Q9H2D1 6 +Folic acid binding 0.5402576865791962 1.582441232225612 0.1135488782266342 1.0 0.2090226288988247 3 P41440 1 +Gated channel activity 0.6298775077652469 1.5712525451903312 0.1161239992367217 1.0 0.2128939986006566 9 P45880,P21796 2 +Oxidoreductase activity acting on a sulfur group of donors 0.4626372734211196 1.5656903434127494 0.1174211280630492 1.0 0.2146902517152779 25 P09622,Q9UHG3,Q6DKJ4 3 +S adenosylmethionine dependent methyltransferase activity 0.4176706549852821 1.5500116453257846 0.1211387209415235 1.0 0.2203499860191878 40 Q03164,Q9BZ95,O96028,Q9BV44,O43159,P26358,Q96KQ7,Q99873,Q86X55,Q7Z2T5,Q08J23,Q14166,Q7Z4G4,Q15047,O60725 15 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.4493194253978777 1.535140895079263 0.124749222854029 1.0 0.2256493295741995 28 Q9NVH6,Q16850,Q9BU89,P09601,Q15800,P30519,Q9H6W3 7 +Deoxyribonuclease activity 0.5002783599466143 1.5303371126148844 0.1259333064501033 1.0 0.2270172247387563 19 P27695,Q8IV08,P28340,Q9UQ84,Q66K74,Q9Y2C4 6 +Chemoattractant activity 0.5826977962230935 1.5242883800556897 0.127436688578403 1.0 0.2289620926561615 4 P14174 1 +Insulin receptor binding 0.6815251653018896 1.5204585942579112 0.1283957576419849 1.0 0.230092000118683 6 O14654,Q06124,Q13596 3 +Mannose binding 0.6595547305091272 1.5101086919557336 0.1310156919728899 1.0 0.2332424095254212 7 P49257,P11717,O75503 3 +3 5 dna helicase activity 0.6377290549203802 1.503561431619196 0.1326943281390966 1.0 0.2355846494066954 8 P46063,Q14566,Q08211,Q8N3C0 4 +Aspartic type endopeptidase inhibitor activity 0.4702183984116595 1.4750185044701332 0.1402075685743735 1.0 0.2473283445647033 2 P04406 1 +Cytokine activity 0.6674098165588446 1.4576095109974478 0.1449482065682632 1.0 0.2543643624991701 6 P43490,P14174 2 +Dna insertion or deletion binding 0.5639072847682023 1.4280453486614817 0.1532788062138841 1.0 0.2665632709606493 4 P20585,P12004,P52701 3 +Growth factor binding 0.5549492278041408 1.415201509246355 0.1570094221552662 1.0 0.2712238253443437 11 Q99523,P27695,Q92896 3 +P type transmembrane transporter activity 0.5594291157833514 1.405044343103199 0.160008092713479 1.0 0.2747347074128644 4 P05023 1 +Phosphatidylcholine binding 0.6149443406616586 1.3935613031080565 0.163450120874637 1.0 0.279227289827505 8 P45880,Q14108 2 +Carboxylic acid binding 0.4013613738707749 1.3794266879755634 0.167763235475693 1.0 0.285873624179613 39 P11717,P11182,P04818,Q15067,P07602,P41440,Q9NZJ7,O15254 8 +Nitrite reductase activity 0.553526701267077 1.3746970500169862 0.1692253861922075 1.0 0.2880024497082475 4 O43169,Q5VT66 2 +Phospholipase activity 0.5177236667705161 1.3668891282070263 0.1716600601971858 1.0 0.2914128750900783 13 Q8NHP8,Q8IV08,Q8NCC3 3 +Glycosaminoglycan binding 0.483778535208422 1.3651190705504124 0.1722156290562115 1.0 0.291989656783276 18 P15586,P05067,P10586 3 +Iron ion binding 0.466136474865139 1.3538028501465238 0.1757992841367064 1.0 0.2969493526054479 20 Q16850,Q9BU89,Q15800,P22830,Q9H6W3 5 +Methyl cpg binding 0.5652934566013175 1.3513992586881258 0.1765675711508119 1.0 0.2978752166671428 10 P84090,Q9UFC0,P26358 3 +Nuclear export signal receptor activity 0.6057118190980514 1.3488563456203553 0.17738311232306 1.0 0.2988783947361148 8 Q9C0E2,Q9HAV4,P62826,Q9UIA9 4 +Nadplus adp ribosyltransferase activity 0.5470325947412871 1.3412726056588689 0.1798319606447656 1.0 0.3025429102968917 4 P09874 1 +Single stranded dna helicase activity 0.517503743085344 1.3326285682609984 0.1826537252279514 1.0 0.3050993706585411 12 P33991,P35250,Q14566,Q08211 4 +Acyltransferase activity 0.3500835572083758 1.325353224081589 0.1850540236159648 1.0 0.3087276127649819 55 Q8IVS2,Q6P1A2,Q9HCL2,Q14CX7,Q9BWD1,P11182,Q9NPF4,Q8NCC3,P40939,O15269,Q99943,Q6UWP7,Q96N66,Q9NRL2,Q9UKG9 15 +Intramolecular oxidoreductase activity transposing c c bonds 0.6158961916846936 1.307434380252098 0.1910652273555184 1.0 0.3164152418751731 7 P14174 1 +Transmembrane transporter binding 0.4289710331933565 1.3047318009099498 0.1919841888759013 1.0 0.317548419986668 25 P30536,P21796 2 +Heparin binding 0.5095890398870552 1.286272733749502 0.1983478948625874 1.0 0.3268753979891361 12 P05067,P10586 2 +Histone lysine n methyltransferase activity 0.4977015041989373 1.2814924806714516 0.2000207393785342 1.0 0.3284321121106273 14 Q03164,Q9BZ95,O96028,Q96KQ7,Q14166,Q15047 6 +Lysine n methyltransferase activity 0.4977015041989373 1.2814924806714516 0.2000207393785342 1.0 0.3284321121106273 14 Q03164,Q9BZ95,O96028,Q96KQ7,Q14166,Q15047 6 +Gtpase activating protein binding 0.5776105947216417 1.264562087394687 0.2060283508967899 1.0 0.3366622690378705 5 Q13526,P07437 2 +Inorganic molecular entity transmembrane transporter activity 0.3360431760095998 1.2560439486704915 0.2091000364002624 1.0 0.3408582521078976 71 P21796,P00846,P00403,Q9HC07,P45880,Q99797,Q13423,O43681,Q9HD20,P31930,Q9UDW1,Q9UBX3,Q00535,Q15043,Q93050 15 +Endoribonuclease activity 0.4336776623236509 1.2543056769179828 0.2097309213194225 1.0 0.341475254567002 23 Q9BRJ7,P27695,Q9UQ84,Q99598,Q96DE0,Q9ULX3 6 +Isopeptidase activity 0.5468365413981173 1.2536046730215011 0.2099857318659252 1.0 0.3414792009790828 10 P49773 1 +G protein alpha subunit binding 0.5252862428683808 1.229180259396964 0.2190042285736766 1.0 0.3535951327687165 4 P80303,P11717 2 +Pyrimidine nucleotide binding 0.5691965116460427 1.2241816925146969 0.2208836938562961 1.0 0.3556210739995853 5 Q9H773 1 +Leucine binding 0.4751608569531502 1.2182910871580217 0.2231133758405008 1.0 0.3572454408428374 3 Q8IWV8 1 +Lipopolysaccharide binding 0.5949981084448243 1.2100648970585848 0.2262539915462782 1.0 0.3605673151497225 7 Q8WTV0,P09429 2 +G protein beta subunit binding 0.4242223692918688 1.192010906318236 0.2332569688659891 1.0 0.370418637178032 2 P48643 1 +Potassium channel regulator activity 0.5618795059064365 1.1890684117244146 0.2344127474099808 1.0 0.3713822567279907 5 Q9UHD1 1 +Importin alpha family protein binding 0.6066932140228747 1.1857494687562038 0.2357212523116341 1.0 0.3730185431317437 6 Q08211,Q08379,P62826 3 +Ubiquinone binding 0.4222369291859799 1.179771677423932 0.2380910370231457 1.0 0.3755475864218714 2 P21912 1 +Pentosyltransferase activity 0.4808892804389812 1.1790064122305826 0.2383956225210683 1.0 0.3755475864218714 14 P43490,Q13126 2 +Trna methyltransferase activity 0.6051701088360925 1.1789208498268446 0.2384296945575665 1.0 0.3755475864218714 6 Q7Z2T5,Q08J23,Q7Z4G4 3 +Quaternary ammonium group binding 0.4855263769865119 1.1745942379545575 0.2401570896504283 1.0 0.377389712307816 13 P45880,Q14108 2 +Glutathione oxidoreductase activity 0.420582395764401 1.1695738918658594 0.2421724890432108 1.0 0.3801152873265247 2 Q86SX6 1 +Transforming growth factor beta receptor binding 0.464676985885394 1.1593932537104306 0.246295925410801 1.0 0.38613949835552 3 Q9UNH7 1 +Endonuclease activity 0.381857473860528 1.149176161477142 0.2504833484861488 1.0 0.3895447936801832 35 Q9BRJ7,P27695,Q9Y4W2,O94919,Q9UQ84,Q96DE0 6 +Ligand gated ion channel activity 0.4169424222369402 1.1471454953898128 0.2513214935545229 1.0 0.389730091700133 2 Q96ER9 1 +Potassium ion transmembrane transporter activity 0.5086808086475932 1.143574059566833 0.252800324700337 1.0 0.3906796484274079 4 Q92581,P05023 2 +Anion transmembrane transporter activity 0.3774630275697414 1.1433297390028645 0.252901712085315 1.0 0.3906796484274079 38 P45880,O43681,P41440,Q9Y619,Q9H2D1,Q9UBX3,Q15043,P21796 8 +Isoprenoid binding 0.508612865271109 1.1432240443808337 0.2529455816869248 1.0 0.3906796484274079 4 P11717 1 +Endodeoxyribonuclease activity 0.5227364714349046 1.1258904613652834 0.2602118873275398 1.0 0.399621661241954 10 P27695,Q9UQ84 2 +Phosphoric diester hydrolase activity 0.5207585257960079 1.115422946059155 0.2646692210752679 1.0 0.4046298939150706 10 P09601,Q8IV08 2 +Nucleotide diphosphatase activity 0.4544852697782245 1.102204967399201 0.2703725729205886 1.0 0.4110270687208498 3 Q9BQG2,Q9BY32 2 +Sulfur compound binding 0.3590217506568428 1.0922722223533408 0.2747134659675949 1.0 0.4171574853581997 45 P15586,P35610,P29401,P43034,P11182,Q96RQ3,O00763,P40939,Q06481,Q92947,Q99873,Q53GQ0,P05067,P10586,O14737 15 +Sh2 domain binding 0.5839691229793438 1.0839861462466232 0.2783709414171529 1.0 0.4212929348293153 6 Q96T51,P63244,P63167 3 +Channel inhibitor activity 0.4919769489216036 1.057654154806802 0.2902131434042756 1.0 0.4358028668434905 4 Q13557 1 +Dihydropyrimidinase activity 0.4007279947054987 1.0474407407338422 0.2948963498472294 1.0 0.4418546637245863 2 Q16555 1 +Growth factor receptor binding 0.4495143319560096 1.0198424582127057 0.3078031831317593 1.0 0.4561420665687518 15 Q9NZ08,P05067 2 +Lamin binding 0.5193264622094977 1.0131329120881258 0.3109966796691106 1.0 0.459867221412357 9 Q9UH99,Q14739 2 +Dna clamp loader activity 0.5523781305237617 1.011988765013211 0.3115434252890914 1.0 0.4601727668298479 7 P41440 1 +Lipase activity 0.4469519616957826 1.0040076485620206 0.3153749269517512 1.0 0.464989912912383 15 Q9H6V9,Q8NHP8,Q8IV08,Q8NCC3 4 +Oligopeptide binding 0.4802358196096573 0.9974988101891772 0.3185224510395721 1.0 0.4684357350614577 4 P48637,Q9H7Z7 2 +Inorganic anion transmembrane transporter activity 0.4392505914002 0.9900223057761346 0.3221632165091281 1.0 0.4727622906039592 16 P45880,O43681,Q15043,P21796 4 +Glutamate binding 0.3884844473858441 0.9725387905800744 0.3307825767675236 1.0 0.483836569044821 2 P15104 1 +Hydrolase activity acting on carbon nitrogen but not peptide bonds 0.3887420162564796 0.9543597848228176 0.3399015552791242 1.0 0.495567677039499 24 P49773 1 +Organophosphate ester transmembrane transporter activity 0.467614790917083 0.9308172324221632 0.3519481141397187 1.0 0.510032369804621 11 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Nucleotide transmembrane transporter activity 0.467614790917083 0.9308172324221632 0.3519481141397187 1.0 0.510032369804621 11 P41440,Q9H2D1,Q8TB61,Q9BSK2 4 +Dynein light intermediate chain binding 0.5053263260790951 0.9192857231182948 0.357946143394392 1.0 0.5168635346986259 5 Q96ED9 1 +Trna guanine methyltransferase activity 0.5041849983366202 0.913900974711924 0.3607688814593537 1.0 0.5187250761046819 5 Q7Z2T5,Q7Z4G4 2 +Gtpase inhibitor activity 0.5423504867872431 0.8991754143907134 0.3685592336500163 1.0 0.5293637400514565 6 O00410,O43924 2 +Hydrolase activity acting on glycosyl bonds 0.3731727218680316 0.8945372887907079 0.3710344879380889 1.0 0.5306656048416852 26 P27695,P06280,Q9NUJ1,P08236,P35573,P16278,O75503,O60502 8 +Serine type endopeptidase inhibitor activity 0.5364800780663134 0.8733958156663898 0.3824473709443408 1.0 0.545259528859529 6 P05067 1 +Glucosidase activity 0.4946206175851735 0.8689285544153293 0.3848862101626582 1.0 0.548158991947449 5 P35573,P10253 2 +Anion channel activity 0.4902135950377634 0.8677846814931636 0.3855122175110776 1.0 0.5482047927716424 9 P45880 1 +Carbohydrate derivative transmembrane transporter activity 0.4726873743354702 0.8632344487649155 0.3880085768547612 1.0 0.5502888935896142 10 L0R6Q1,P41440 2 +Histone h3 methyl lysine 4 demethylase activity 0.4523399353152684 0.8559754162358884 0.3920113776449367 1.0 0.5536444613294358 4 Q9H6W3,Q8NB78 2 +Copper ion binding 0.486206748068869 0.8479864520529443 0.396445515825099 1.0 0.5561795218376133 9 P00403,Q99497,O60888 3 +Histone kinase activity 0.5119967744204139 0.8270553785519295 0.4082056738588786 1.0 0.5699713898153382 7 Q9UIG0,P24941,O14965,P06493 4 +Cytokine receptor binding 0.3815336038494737 0.8111510380222995 0.4172789391323488 1.0 0.5808419800885473 21 P14174 1 +Nadplus binding 0.5204311291172861 0.8034546170489143 0.4217120176703597 1.0 0.5846069261352426 6 P40939,P00367 2 +Lysine acetylated histone binding 0.4260882272475427 0.8014232950835999 0.422886633619735 1.0 0.5851936420753727 12 Q03164,Q9NPI1,Q86X55 3 +Histone methyltransferase activity h3 k36 specific 0.4785868320663629 0.794259523838117 0.4270443624271713 1.0 0.5895826758815947 5 Q9BZ95,O96028 2 +Protein homodimerization activity 0.2670435829856502 0.7853265755720618 0.4322621180865527 1.0 0.5955709223738348 161 Q14108,Q14849,P09601,P22830,Q9NZJ7,P49815,Q9Y6K9,Q13555,P04818,P07602,P19474,P09493,Q9BRJ7,O75569,P42892,Q06481,O15111,Q96DE0,Q9Y6X9,Q13557,O75531,Q15067,P16278,P67936 24 +Pre mrna intronic binding 0.4762504193898743 0.7834677437318113 0.4333524884128976 1.0 0.5964658360352497 5 Q9BWF3,Q6P2Q9,P14866 3 +3 5 exodeoxyribonuclease activity 0.4975383539202829 0.7621091422560051 0.4459948668702247 1.0 0.6095263180559738 7 P27695,P28340 2 +Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor 0.370486556650459 0.759288298782469 0.4476801156223455 1.0 0.6105959641502354 22 P30837,P09622 2 +Organic anion transmembrane transporter activity 0.3578387703621515 0.7564632826896132 0.4493714786175111 1.0 0.6122856098383611 25 Q9Y619,Q9H2D1,Q9UBX3,P41440 4 +Camp dependent protein kinase regulator activity 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.6178893279109472 2 P10644 1 +Camp dependent protein kinase inhibitor activity 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.6178893279109472 2 P10644 1 +Metal ion transmembrane transporter activity 0.3687266675783479 0.7469053276754918 0.4551207097964576 1.0 0.6182513256572361 22 Q9HC07,P05023,P98194,Q9HD20,Q00535,Q15043 6 +Dicarboxylic acid transmembrane transporter activity 0.493346630836859 0.7434513866185193 0.4572084431314789 1.0 0.6204644168073129 7 P41440 1 +Hydrolase activity hydrolyzing o glycosyl compounds 0.3764026234265918 0.7327948225262999 0.4636835796014229 1.0 0.6286211254516284 20 P06280,Q9NUJ1,P08236,P35573,P16278,O60502 6 +Carboxylic ester hydrolase activity 0.3444993671413013 0.7278240440876614 0.4667213040184195 1.0 0.630633948358983 30 Q9NUJ1,Q8NCC3 2 +Rna polymerase ii c terminal domain phosphoserine binding 0.3863516036842424 0.7273155406900526 0.4670326801594242 1.0 0.630633948358983 3 Q92541 1 +Cyclin binding 0.4288276772035985 0.7215564149894881 0.4705672440500321 1.0 0.632461036140637 11 Q9BWF3,O14976,Q96JB5,P11802,P63244,P06493 6 +Atpase binding 0.3456249619224856 0.7028973038998595 0.482119751478693 1.0 0.6458495284660115 28 P55769,Q93050 2 +Structural constituent of cytoskeleton 0.330838660491073 0.6910904551631664 0.4895086981549528 1.0 0.6538057932908699 32 P07197,Q9UEY8,O15143,P08670,O15020,P68371,Q9BUF5,Q96CW5,Q16204,P09493 10 +Sulfurtransferase activity 0.3790135716650061 0.6884600432327393 0.491163123972326 1.0 0.6547228637778887 3 O75648,P25325 2 +Protein dimerization activity 0.2395511275199462 0.6812203666129265 0.4957320628013213 1.0 0.6588658948626598 215 Q14108,Q14849,P09601,O14965,P22830,Q9NRF9,Q9NZJ7,P49815,O95831,Q9Y6K9,Q13555,P04818,P07602,P19474,P09493,Q9BRJ7,O75569,Q9NRG0,Q9NR33,P42892,Q06481,O15111,Q96DE0,Q9Y6X9,Q13557,O75531,Q15067,P16278,P67936 29 +Phosphatidylinositol kinase activity 0.4167092033688609 0.6802059744833363 0.4963740499199431 1.0 0.6590717267337419 4 P42356,O00443 2 +Cysteine type endopeptidase activity 0.3681055344104684 0.6776591640120704 0.4979878239688553 1.0 0.6595549840215926 20 O15484,P53634,Q99538,Q93009,Q86UV5 5 +Protease binding 0.3550684040794707 0.6767638581474718 0.4985557926747521 1.0 0.6595549840215926 23 P07602,P14174,P46379,P41440 4 +Myosin binding 0.3957522555503481 0.6707854862491313 0.5023571947005809 1.0 0.6633976503151087 14 P61586 1 +Sequence specific single stranded dna binding 0.4632754047316331 0.6691837512136035 0.5033782700465319 1.0 0.6638116952952804 8 Q15365 1 +Active ion transmembrane transporter activity 0.3250784056376565 0.6644682367330057 0.5063906718609368 1.0 0.665837297403156 37 P08574,P20674,P00403,P05023,P14854,Q9HD20,P31930,P41440,Q9UDW1,Q15043 10 +5 deoxyribose 5 phosphate lyase activity 0.3342157511581806 0.6503899904868689 0.5154403412489366 1.0 0.6752072842039326 2 P13010 1 +Gtpase binding 0.2738503327880549 0.6422705177066327 0.5206975533781764 1.0 0.6793672032021915 91 Q9Y333,Q8WUW1,Q8TBA6,P50748,Q96F07,Q14C86,Q27J81,Q9Y2T2,P49815,P07737,P21333,Q9Y4I1,Q9UI26,Q9UIA9,Q7L576,Q92973,O15397,P62873,Q01082,Q13576,O43924,Q8IYI6,Q96KP1,Q9Y5L0,Q9NVG8,Q9P258,Q01968,O00410,P50542,P61970,P49792,P16989,O60879 33 +Oxidoreductase activity acting on the aldehyde or oxo group of donors 0.3453579911597983 0.6347931747933023 0.5255633152773362 1.0 0.6837376592021499 24 P30837,P09622 2 +Transcription coregulator binding 0.3478180866961198 0.6259882088359459 0.5313226753165889 1.0 0.6892421665420373 23 Q15369,Q9UQB8,O75530 3 +Nucleocytoplasmic carrier activity 0.3567899172496323 0.6038116541584536 0.5459688703346277 1.0 0.7021823969227673 20 Q9HAV4,O00410,Q9UI26,Q9C0E2,P62826,Q9UIA9,Q9Y5L0,Q92973,Q8TEX9 9 +Cysteine type peptidase activity 0.3132576976992507 0.5871544804421003 0.5570999606430993 1.0 0.7144608973934723 40 Q6P2Q9,Q92890,O15484,Q7L5N1,Q13867,P53634,Q99538,Q93009,Q9Y5K5,P49773,Q9BT78,Q86UV5 12 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0.4668297054796271 0.5783337548435109 0.5630388093078915 1.0 0.7186712348996012 6 O43169,Q5VT66 2 +Peptidase activator activity 0.3846669537354423 0.5735721577429453 0.5662573570607665 1.0 0.7211802356759391 12 Q9BXK5,P63244,P61289,P55072,P53634,P05067 6 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.3929534791629592 0.5680670299331237 0.5699894540777926 1.0 0.7248080182023058 4 Q9UHQ9,P00387 2 +Oxidoreductase activity acting on ch oh group of donors 0.2871639416602745 0.5654146335474765 0.5717917734778837 1.0 0.7264171544747199 53 P35270,Q8N8N7,Q14914,Q8N4Q0 4 +Hsp90 protein binding 0.3547786289070097 0.5580564277592159 0.5768058528229065 1.0 0.7314136071878093 19 Q9UHD1,Q15185,P49815 3 +Carbohydrate kinase activity 0.460488739122252 0.5528950177358147 0.580335299263943 1.0 0.7338258503776774 6 P52789 1 +Cyclosporin a binding 0.409616740734831 0.5487244614699065 0.5831945564956134 1.0 0.7367527870574835 10 P49792,P30414,Q13427,Q08209 4 +Nucleobase containing compound kinase activity 0.3601830349754766 0.535208206823765 0.5925058919735029 1.0 0.7450376132343396 17 Q5SY16,Q5KU26,P55263 3 +Active transmembrane transporter activity 0.2791265094340535 0.5321164212989901 0.5946453646664884 1.0 0.7470335918233602 64 Q9Y6M9,P20674,P00403,P08574,P05023,P14854,P53985,O95298,Q9HD20,Q15388,P31930,O75251,P51970,P41440,P08183,Q9UBX3,Q9UDW1,Q15043 18 +Polyubiquitin modification dependent protein binding 0.3665760322947931 0.527231758769674 0.598032656765523 1.0 0.7498609629923878 15 Q6P2Q9,Q9Y6K9,P46379,P55072,P35573 5 +Rna polymerase ii c terminal domain binding 0.4479309180764785 0.5034860665299323 0.6146225741359368 1.0 0.7657314390478108 6 Q92541,Q00839 2 +Carbon sulfur lyase activity 0.4472536502107878 0.5008605385491026 0.6164692762939428 1.0 0.766620340832449 6 O14880,P32929 2 +Rna methyltransferase activity 0.3626796853710307 0.4881914987693537 0.6254142055500522 1.0 0.7741861117193235 14 Q9BV44,O43148,Q8IY81,Q7Z2T5,Q08J23,Q7Z4G4 6 +Cytoskeleton nuclear membrane anchor activity 0.3736092488871934 0.481011183554411 0.630508550328968 1.0 0.7789219163855604 4 Q9UH99 1 +Intramolecular oxidoreductase activity 0.3257104473646213 0.4766100234150104 0.6336398445320612 1.0 0.7799676156133756 23 Q15185,P14174 2 +Primary active transmembrane transporter activity 0.2922549474088279 0.4751574172871144 0.6346747759839355 1.0 0.7799676156133756 46 Q9Y6M9,P20674,P00403,P08574,P05023,P14854,O95298,Q9HD20,Q15388,P31930,O75251,P51970,P08183,Q9UDW1 14 +C2h2 zinc finger domain binding 0.3366108204520595 0.4751269571456888 0.6346964854326138 1.0 0.7799676156133756 3 Q96KQ7 1 +Modification dependent protein binding 0.2732022736895417 0.4723424020857236 0.6366824092817316 1.0 0.7806114494408701 57 Q03164,P25440,Q92890,Q9Y6K9,Q6P2Q9,O43159,Q15022,Q86XI2,P46379,Q9NPI1,Q86X55,P55072,P42695,P35573,Q12888,Q14166,Q9UFC0,Q12830 18 +Phosphatidylinositol 4 5 bisphosphate binding 0.3616252600885598 0.467721352597757 0.6399838693399551 1.0 0.7817055367738914 13 P07737,Q9NV70,O95425 3 +Phosphofructokinase activity 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.7830975577508519 3 Q01813,P17858 2 +Fructose 6 phosphate binding 0.3333333333333271 0.4596510648766661 0.6457666994532132 1.0 0.7830975577508519 3 Q01813,P17858 2 +Fructose binding 0.3333333333333212 0.4596510648766382 0.6457666994532332 1.0 0.7830975577508519 3 P04075,P17858 2 +C3hc4 type ring finger domain binding 0.3325474683725582 0.4559663556966801 0.648414171910586 1.0 0.7852264092080959 3 P31689 1 +Symporter activity 0.4226256103839155 0.4463413866328242 0.6553506650210712 1.0 0.7908898998268323 7 P53985,Q15043,Q9H936 3 +Demethylase activity 0.3978958888647811 0.4379496280386561 0.6614227987663412 1.0 0.7937652845632371 9 Q16850,Q8NB78,Q7LBC6,Q6P6C2,Q9H6W3 5 +Mannosyltransferase activity 0.4256759699177708 0.4195626421762908 0.6748049840078818 1.0 0.8037069923967114 6 Q9BV10 1 +Atpase coupled transmembrane transporter activity 0.3314728028210513 0.3958240693279504 0.6922348192250727 1.0 0.820427049032996 18 Q9HD20 1 +Cytoskeletal motor activity 0.3031807028736469 0.3897062099419718 0.6967538040066659 1.0 0.8233256740794924 29 P60660,Q9Y4I1,Q13526,P35580,P35579 5 +Nadh dehydrogenase activity 0.3245682715875024 0.3801088432840722 0.7038646216084228 1.0 0.828501483975594 19 P51970,O95831,O95298,O75251 4 +Protein tyrosine kinase activity 0.3436972159540381 0.3788382407935938 0.7048079882157492 1.0 0.828501483975594 13 Q96KB5,Q9UIG0,P11717 3 +Long chain acyl coa dehydrogenase activity 0.3464296988234659 0.3671687522853255 0.7134931460632938 1.0 0.8350832410239071 4 Q9NZ01 1 +Protein tyrosine phosphatase activity 0.3774749034037885 0.3547823848963307 0.7227526258719155 1.0 0.8404740357938939 9 P10586,Q9Y217 2 +Transketolase or transaldolase activity 0.3098886156938948 0.3545114674029931 0.7229556116149998 1.0 0.8404740357938939 3 P29401 1 +1 phosphatidylinositol 4 kinase activity 0.309139990074572 0.3513310407766978 0.7253400101825362 1.0 0.8416681250231317 3 P42356 1 +Protein serine threonine tyrosine kinase activity 0.2645547310626142 0.3498662848927598 0.7264390506031757 1.0 0.8422211100823451 53 O14976,Q05655,Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O95747,Q9UIG0,Q00535 11 +Nadp binding 0.3282812703616658 0.3426307944215211 0.7318762322727215 1.0 0.8463491814230703 16 Q13423,Q14739 2 +Biotin binding 0.3686453819442299 0.3324567029601921 0.7395444281581902 1.0 0.8514596643691792 5 Q96RQ3 1 +Organic acid binding 0.2830591804822535 0.3319314390172825 0.7399410300838059 1.0 0.8514596643691792 38 P11717,P00367,P23378,P34897,P34896,P11182,P04818,Q8IWV8,P54136,P27708,P41440 11 +Proton transmembrane transporter activity 0.2828392379751172 0.3303164435132942 0.7411608694598759 1.0 0.8516499958801867 38 P00846,P00403,Q13423,P31930,Q9UDW1,Q93050 6 +Ubiquitin like protein specific protease activity 0.292353935625249 0.3174932044946958 0.7508693949921932 1.0 0.8565988966479235 29 Q6P2Q9,Q92890,Q7L5N1,Q93009,Q9Y5K5,P49773,Q9BT78,Q86UV5 8 +Mirna binding 0.3226689347987854 0.3150800461028412 0.7527008783926883 1.0 0.8574448060204176 16 Q9UGR2,Q8IWR0,P98175 3 +Ankyrin binding 0.2989690113877771 0.309328094978777 0.7570719615283599 1.0 0.8587987020942384 3 Q01082 1 +Ligase activity forming carbon carbon bonds 0.384599462909003 0.3075851903943886 0.7583979905862686 1.0 0.8587987020942384 7 O00763,Q96RQ3 2 +Aldehyde lyase activity 0.3600529976813615 0.3023881130994614 0.7623562152467036 1.0 0.8609916187218614 5 O95470,P04075,P09972,Q9UJ83 4 +Antiporter activity 0.3518404038483521 0.2983978196226557 0.7653995529989865 1.0 0.8629879960063573 10 P41440 1 +Retinal binding 0.2634017207147676 0.2905110190076025 0.7714253221533456 1.0 0.8685202247883698 2 O94788 1 +Protein kinase a catalytic subunit binding 0.3514408744617589 0.2734841849610627 0.7844810477089463 1.0 0.8802376782617894 5 P49840,P41240,P15311,P10644 4 +3 hydroxyacyl coa dehydrogenase activity 0.3821858925012644 0.2724803722531572 0.7852526811988025 1.0 0.8802376782617894 6 Q16836,P40939 2 +Signal sequence binding 0.2836910766508296 0.2700933228123096 0.7870884589058544 1.0 0.880835967658909 27 Q9Y584,P24390,Q15388,P50542 4 +Secondary active transmembrane transporter activity 0.3065918850768754 0.2671440111001614 0.7893582825579328 1.0 0.8808918035236022 18 Q15043,P41440 2 +Nucleotidyltransferase activity 0.2681261085495571 0.2666448570404508 0.7897426146889353 1.0 0.8808918035236022 45 Q13057,P28340,P30876,Q9NRG0,Q9NR33,Q8NFW8,P09884,Q9H9Y6,Q9NRF9,Q15185 10 +Telomeric dna binding 0.3051580173369075 0.2602487699785977 0.7946718869171603 1.0 0.8848446966793432 18 P22626,P27695,O60341,Q14103,P13010,Q12888,Q9NYB0,Q9UPR3 8 +Nucleoside binding 0.3173977025452102 0.2595013393546589 0.7952484487524623 1.0 0.8848446966793432 4 Q9H9Y6 1 +Regulatory rna binding 0.3014115883164934 0.2584248173482259 0.7960790654412995 1.0 0.8850410645374512 19 Q9UGR2,Q5T280,Q8IWR0,P98175 4 +Nuclease activity 0.2504350975607876 0.2545770283139213 0.799049803468276 1.0 0.887614436857617 70 Q9BRJ7,P27695,Q8IV08,O94919,Q9UQ84,Q96DE0,Q9Y3B2 7 +Disulfide oxidoreductase activity 0.2949400798934805 0.2444076001583063 0.8069151561625783 1.0 0.8948821363016134 20 Q96JJ7,Q6ZRP7,O43396,P00390,O95881,P07237,P13667,P78417,P30101,Q9BRA2,Q8IXB1,Q9H3N1,Q9Y320,O76003,O43819,P00558,Q86SX6,Q96HE7,Q6DKJ4 19 +Dynein intermediate chain binding 0.3539429375020129 0.236037659503762 0.8134034475988758 1.0 0.8998161512150312 8 P62826,P63167 2 +Rna 7 methylguanosine cap binding 0.3392122240975143 0.2176764880779759 0.827681184206756 1.0 0.9110783287091972 9 Q7L576,Q09161 2 +Amino acid binding 0.3011537733681874 0.2172078984090509 0.8280463295825331 1.0 0.9110783287091972 16 P00367,P23378,P34897,P34896,Q8IWV8,P54136 6 +Dipeptidase activity 0.3023178807946879 0.2103722708544743 0.8333771330442998 1.0 0.9137433233459789 4 Q8IYS1,P12955,Q12765 3 +Protein serine kinase activity 0.2545703392535648 0.2071769007860627 0.8358717064504961 1.0 0.914540736107422 49 O14976,Q05655,Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O95747,Q00535 10 +Arachidonate coa ligase activity 0.3003311258277999 0.2042784909903092 0.8381358772749992 1.0 0.9159012380937404 4 O95573,P33121,O60488 3 +Enoyl coa hydratase activity 0.358206250427011 0.2031973703284512 0.838980768136038 1.0 0.9159012380937404 6 P40939 1 +Rdna binding 0.2697782191327288 0.2026521834506805 0.8394068996572344 1.0 0.9159012380937404 3 P42345,Q9H6R0 2 +Oxidoreduction driven active transmembrane transporter activity 0.2723217555297653 0.1994420256678319 0.8419169890211777 1.0 0.9171607778950512 28 Q9Y6M9,P20674,P00403,P08574,O95298,P31930,O75251,P51970,Q9UDW1 9 +Purine nucleotide transmembrane transporter activity 0.3323564226493448 0.1961151568231264 0.8445200331877096 1.0 0.9192563193105158 9 P41440 1 +Four way junction dna binding 0.3224045744658425 0.1860199269498444 0.8524291346147399 1.0 0.9241479319981916 5 P09429 1 +Phosphatidylinositol binding 0.2477993566045157 0.1815363048370824 0.8559466393885287 1.0 0.9256304429596282 51 P07737,Q8WTV0,Q8IYI6,O95425,Q13045,Q06481,Q96L92,Q9H4A6,Q9NV70,Q9Y5X1 10 +Protein self association 0.2981279833854476 0.1812443577641004 0.8561757786498372 1.0 0.9256304429596282 12 Q9Y282 1 +Protein demethylase activity 0.3491801238314505 0.1796079532003731 0.8574603604738145 1.0 0.9256304429596282 6 Q9H6W3,Q8NB78,Q7LBC6 3 +Phosphatidylinositol bisphosphate binding 0.2916765543629044 0.178413622946671 0.8583981513792096 1.0 0.9256304429596282 16 P07737,Q9NV70,O95425 3 +Mrna 3 utr au rich region binding 0.2963152381547167 0.1781750313563826 0.8585855180445923 1.0 0.9256304429596282 13 Q9H2U1,Q92945 2 +Ribosomal large subunit binding 0.3231311328006321 0.1686892655379205 0.866041062635692 1.0 0.9314416198299612 9 Q96D46,Q9NTK5,P98179,Q9H6R0 4 +Sodium ion transmembrane transporter activity 0.3433198796545907 0.16505817618261 0.8688981919802068 1.0 0.9315581886115468 6 Q6P4Q7,P05023 2 +Monosaccharide binding 0.2643957690395067 0.1524067663077315 0.878866120680154 1.0 0.9385208060617588 29 P49257,P52789,Q5KU26,P11717 4 +Dna polymerase binding 0.30620973244091 0.1446813785104741 0.8849624422416742 1.0 0.9417386713385024 10 Q15185 1 +Calcium ion transmembrane transporter activity 0.285836574084608 0.1420064793779078 0.8870748877531982 1.0 0.9417386713385024 13 Q9HC07 1 +Isomerase activity 0.2376877048500821 0.1412978027819795 0.8876346853273409 1.0 0.9417386713385024 64 P48449,O00170,P14174,Q15125,Q13427,Q15185 6 +Smad binding 0.2859750588004793 0.1404615826352476 0.8882953041373758 1.0 0.9417386713385024 12 P09874 1 +Vitamin b6 binding 0.2713764968143469 0.1371301296525969 0.8909279374081915 1.0 0.9417386713385024 20 Q5VT66,P23378,P34896,O15269,P32929 5 +Dna replication origin binding 0.2835118491445326 0.1344330037782136 0.8930601852498463 1.0 0.9432556054980812 13 Q9BQ67,Q08211,P49736,P09884,Q9Y619 5 +Long chain fatty acid coa ligase activity 0.3004306061609954 0.1310152762388942 0.8957632228793713 1.0 0.9453725745364971 5 Q96CM8,O95573,P33121,O60488 4 +Oxidoreductase activity acting on a heme group of donors 0.319452316360893 0.1234417873577054 0.901757268562544 1.0 0.9502161872002508 7 P20674,P00403 2 +Pre mrna binding 0.2696011079170624 0.1193437421776348 0.9050030298663893 1.0 0.951735019362775 19 Q6P2Q9,P17844,Q00839,P14866 4 +S acyltransferase activity 0.3205449969578879 0.1144200606417098 0.9089048123349688 1.0 0.9528828928010444 6 Q8IVS2 1 +Passive transmembrane transporter activity 0.2517648180514847 0.11436802714706 0.9089460582998818 1.0 0.9528828928010444 31 P45880,P00846,Q99797,P21796 4 +G rich strand telomeric dna binding 0.2921497184498313 0.1129266055428672 0.9100887430726048 1.0 0.9528828928010444 5 P22626,P09651,Q9NYB0,P15927 4 +Protein c terminus binding 0.244202093600083 0.112248411032632 0.9106264452267188 1.0 0.9528828928010444 46 Q9UQB8 1 +K48 linked polyubiquitin modification dependent protein binding 0.2902526595842375 0.1089886192022918 0.913211517121028 1.0 0.9547690539869798 5 P55072 1 +Structural constituent of nuclear pore 0.2612818429358283 0.0977390191918158 0.9221395310383356 1.0 0.9593423618670436 20 Q5SRE5,Q9BTX1 2 +Electron transfer activity 0.2353618520006691 0.0973205337747036 0.9224718498071128 1.0 0.9593423618670436 51 Q9Y6M9,P20674,P00403,O43488,P14406,P08574,P23378,O95298,P31930,O75251,P51970,P00390,Q9UDW1 13 +Estrogen receptor binding 0.2683147761223763 0.0890744899759934 0.92902271084006 1.0 0.9654130013568364 13 P09874 1 +5s rrna binding 0.3065618563387948 0.0880706426196197 0.9298205294846116 1.0 0.9655005191041286 6 P39023,P46777 2 +Nuclear import signal receptor activity 0.2675630103839647 0.0870701589968477 0.9306157449497504 1.0 0.9655852016234758 12 Q9UI26,Q92973,Q9Y5L0,O00410 4 +Protein phosphatase 2a binding 0.2888100012399602 0.0835241842006981 0.9334347483644684 1.0 0.96702696365783 9 Q86XL3,P78318 2 +Translation repressor activity mrna regulatory element binding 0.3015194399945851 0.0794546545529803 0.9366709979572811 1.0 0.9688959176117748 6 P34896,P04818 2 +Fatty acid ligase activity 0.3005301524188141 0.0778189596252227 0.9379720645827244 1.0 0.9695005373418076 6 O95573,Q96CM8,P33121,O60488,Q4G176 5 +Clathrin binding 0.2571439321964869 0.0752291022404881 0.940032429715984 1.0 0.9701723438822824 19 Q5VW38 1 +Dna helicase activity 0.2411591875627712 0.0703749023053024 0.9438952667685784 1.0 0.9726506442786644 37 Q9H2U1,P33991,Q14566,Q08211,P46063,P35250,Q9H4L7 7 +Manganese ion binding 0.2527586131107234 0.0677582911494246 0.945978046257947 1.0 0.9740550202336395 20 Q10472,Q96DE0 2 +Single stranded telomeric dna binding 0.2922465208747446 0.064820654265818 0.9483167963064087 1.0 0.9757206276825636 6 P22626,Q92878,P09651,P15927,Q9NYB0 5 +Adenylyltransferase activity 0.2805039787798373 0.0580529541078914 0.9537064483348944 1.0 0.9790978996917834 8 Q13057,Q15046,Q9NQX3,O95340,P51003,Q9NVV4,O43252 7 +Exonuclease activity 0.2381742933972754 0.0579729639646557 0.9537701639273988 1.0 0.9790978996917834 40 Q9Y3B2,Q8IV08,Q9UQ84 3 +Signaling receptor complex adaptor activity 0.2856696535281336 0.0553769130965073 0.955838188288456 1.0 0.9804769285475972 6 P62873,Q96T76 2 +Lyase activity 0.2204325601540857 0.0473272527697284 0.9622524078449012 1.0 0.9863087180410238 55 P60174,P22830,Q9H7Z7,P42126,Q9P035,P32929,O95470,P40939,Q99497,A1L0T0,Q16822,O14880,P49327,Q9NTX5,P23378,Q04760,P38435,P13010,P09429,P35914 20 +Ribonuclease activity 0.2275511264526784 0.0438006498249379 0.9650633090975732 1.0 0.988441072830444 50 Q9BRJ7,Q9Y3B2,Q9UQ84,Q96DE0 4 +Atp dependent activity acting on dna 0.2210695699063146 0.0408716100779554 0.9673982504042652 1.0 0.9900830807843956 54 Q96QE3,Q9H2U1,Q9H4L7,P33991,Q14566,Q08211,Q8N3C0,P13010,P49736,P46063,Q92499,P41440,P35250,P52701,Q12830 15 +Ubiquitin like protein ligase activity 0.2343524925297887 0.0385015302907253 0.9692878113945592 1.0 0.9910932176518852 38 Q7Z6E9,Q9C0C9,O75448,Q7Z6Z7,Q9ULT8,Q9Y4X5,Q5T4S7,Q8IWV8,P60953,O94874,Q9H1B7,P49792,P19474,O94822,Q14258 15 +Rna stem loop binding 0.2670987804741146 0.0377960753027451 0.9698502735928276 1.0 0.9910932176518852 8 P35580 1 +Fatty acid derivative binding 0.2477972506370657 0.029231940113594 0.9766796075854672 1.0 0.9965667489163929 11 Q9H3P7,P40939,P35610,Q92947 4 +Acyl coa binding 0.2477972506370657 0.029231940113594 0.9766796075854672 1.0 0.9965667489163929 11 Q9H3P7,P40939,P35610,Q92947 4 +Protein serine threonine kinase activity 0.2197490688516682 0.027339203620827 0.9781891885767352 1.0 0.99660389468699 60 O14976,Q05655,Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O15111,O95747,Q99570,O75131,Q00535 13 +Channel regulator activity 0.2408337487224055 0.0255688692374061 0.9796012166979796 1.0 0.9972915321236768 13 Q9UHD1,Q13557,P63244 3 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.2290447867568465 0.0134948380059279 0.9892330039029742 1.0 1.0 31 Q8IV08,Q9UQ84 2 +Rna cap binding 0.2321164384801531 0.013247265040243 0.9894305208921336 1.0 1.0 12 Q7L576,Q09161 2 +Mhc class i protein binding 0.2417905527462407 0.0092686184932293 0.9926048182877673 1.0 1.0 7 P68371,P07437 2 +Histone methyltransferase binding 0.2332670642809786 0.0051524144980124 0.9958889862106246 1.0 1.0 6 O00567,Q13185,O95785,P08238,P35222 5 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..02941f48d35882f36a55c42d739c629e32a2e5fb --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp gated ion channel activity", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "Butyrate coa ligase activity", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix constituent conferring elasticity", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H3 histone acetyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Ige binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate kinase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated cation channel activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular sequestering activity", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin light chain binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus nucleosidase activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nadplus nucleosidase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion antiporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Potassium proton antiporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein self association", "Protein sequestering activity", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoic acid responsive element binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Selenium binding", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Stat family protein binding", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATRX", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD7", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "CAB39", "CACUL1", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHMP3", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM129B", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FOXK2", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPR107", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS4", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZIC", "MACF1", "MAGT1", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL51", "MRPL58", "MRPL9", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NEMF", "NENF", "NES", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCA", "RTCB", "RTF1", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYNCRIP", "SYNE1", "SYNE2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM115", "TMEM165", "TMEM201", "TMEM43", "TMEM70", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSPYL1", "TSR1", "TSTA3", "TTC1", "TTC26", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS18", "VPS25", "VPS33B", "VPS35", "VPS4B", "VRK1", "VRK3", "VTA1", "WARS", "WASF2", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WRAP53", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF598", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABHD10", "ACACB", "ACAD11", "ACAT2", "ACBD3", "ACOX1", "ACOX3", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ADA", "ADD3", "ADK", "AGL", "AGPAT1", "AGPS", "AIFM1", "AIP", "AKAP8", "AKR7A2", "AKT2", "ALDH16A1", "ALDH1A2", "ALDH1B1", "ALDOA", "ALDOC", "ALG12", "ALKBH5", "ANKLE2", "AP3M1", "APEX1", "APLP2", "APOL2", "APP", "ARIH1", "ARPC1B", "ASCC3", "ASNA1", "ATAD5", "ATP13A1", "ATP1A1", "ATP2C1", "ATP6", "ATP6V0A1", "AURKA", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCL2L13", "BLMH", "BPTF", "BRD2", "BRD7", "BRK1", "C1orf123", "CAD", "CAMK2D", "CAMK2G", "CAPN5", "CARM1", "CBX3", "CCDC51", "CCDC6", "CCT5", "CDC42", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CHORDC1", "CHRAC1", "CHUK", "CKMT1A*", "CLCN3", "CLN5", "CMAS", "CNNM4", "COASY", "COLEC12", "COPS4", "COPS6", "COX2", "COX5A", "COX6B1", "COX7A2", "CPD", "CPNE3", "CPOX", "CPVL", "CROT", "CSK", "CTH", "CTNNB1", "CTSA", "CTSC", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DBT", "DCTD", "DCTPP1", "DCUN1D5", "DDX1", "DDX5", "DHCR24", "DHCR7", "DHX33", "DHX36", "DHX9", "DIAPH2", "DLD", "DNAJA1", "DNAJC10", "DNMT1", "DOHH", "DPP9", "DPYSL2", "DYNC2H1", "DYNLL1", "EBP", "ECE1", "ECHDC1", "ECI1", "EED", "EHMT2", "ELOC", "ENDOD1", "EPHX1", "ERAP1", "ERCC6L", "ERGIC3", "ERH", "ERO1A", "EXO1", "EXOC1", "EXOC2", "EXOC8", "EXOG", "EXOSC1", "EZR", "FADS2", "FAM98A", "FASN", "FECH", "FGFR1OP", "FLII", "FLNA", "FOXRED1", "FTSJ3", "GAA", "GAK", "GALNT1", "GAPDH", "GAPVD1", "GCDH", "GGCX", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLRX3", "GLRX5", "GLUD1", "GLUL", "GNB1", "GNPAT", "GNS", "GOLGA2", "GOLGA5", "GOLPH3", "GPAM", "GPHN", "GPR107", "GRWD1", "GSK3A", "GSR", "GSS", "GSTO1", "GUSB", "HACD3", "HACL1", "HADH", "HADHA", "HAGH", "HAUS4", "HECTD1", "HINT1", "HK2", "HLA-C", "HMGB1", "HMGCL", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPD", "HNRNPL", "HNRNPU", "HOOK2", "HS2ST1", "HSD17B12", "HSDL1", "HSP90AB1", "HUWE1", "ICMT", "IGBP1", "IGF2R", "IKBKG", "ILVBL", "INF2", "IPO11", "IPO4", "IPO5", "IPO8", "IQGAP2", "IRF2BPL", "IRS4", "ITPA", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHSRP", "KMT2A", "KNTC1", "LAS1L", "LBR", "LCLAT1", "LDAH", "LGMN", "LMAN1", "LNPEP", "LPCAT3", "LRWD1", "LSM2", "LSS", "LTN1", "MANF", "MAP1S", "MAPK1", "MARC1", "MBOAT7", "MCAT", "MCCC1", "MCM2", "MCM4", "MCM6", "MED24", "METAP2", "METTL13", "MGEA5", "MGST3", "MIF", "MIPEP", "MMS19", "MORC2", "MPST", "MSH3", "MSH6", "MSMO1", "MTAP", "MTCH1", "MTMR6", "MTOR", "MTPAP", "MYH10", "MYH9", "MYL6", "MYO5A", "NAA25", "NAA40", "NAMPT", "NAXE", "NCAPD3", "NCAPG2", "NCBP1", "NCSTN", "NDC1", "NDUFA8", "NDUFB9", "NDUFC2", "NDUFS7", "NEFM", "NENF", "NKTR", "NMD3", "NNT", "NOB1", "NOL9", "NOP56", "NPC1", "NPC2", "NPEPPS", "NRDC", "NSD2", "NSD3", "NSUN2", "NT5C3B", "NT5DC1", "NTMT1", "NUCB2", "NUDT12", "NUDT16", "NUDT16L1", "NUP188", "NUTF2", "NXN", "OCRL", "OLA1", "OPA1", "OSBPL6", "OSGEP", "OXSR1", "P4HB", "PAFAH1B1", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARP1", "PBK", "PCBP1", "PCK2", "PCNA", "PCYOX1", "PDCD5", "PDE6D", "PDIA3", "PDIA4", "PEPD", "PEX5", "PFKL", "PFKP", "PFN1", "PGK1", "PI4KA", "PIK3C2A", "PIK3R4", "PIN1", "PITPNA", "PITRM1", "PLA2G15", "PLBD2", "PLD3", "PM20D2", "PMPCA", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1B", "POLR2B", "PON2", "PPIG", "PPOX", "PPP3CA", "PPT1", "PPT2", "PRCP", "PRDX5", "PREP", "PRKAR1A", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRPF8", "PSAP", "PSMA6", "PSMB1", "PSMB2", "PSMB5", "PSME3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN11", "PTPRF", "QSOX2", "RACK1", "RAD50", "RAN", "RANBP2", "RAPGEF2", "RARS", "RBBP6", "RBM10", "RBM3", "RBM4", "RCC2", "RECQL", "RETSAT", "RFC2", "RHOA", "RIOX1", "RNMT", "RPA2", "RPL3", "RPL5", "RRP8", "RTF1", "RUFY1", "SCARB1", "SCARB2", "SCCPDH", "SCO2", "SCPEP1", "SCRN1", "SDHB", "SEC11A", "SEC24B", "SETDB1", "SF3A2", "SGPL1", "SHMT1", "SHMT2", "SIGMAR1", "SKP1", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A33", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC9A6", "SMARCAD1", "SMG5", "SNU13", "SNX1", "SNX27", "SNX6", "SNX9", "SOAT1", "SORT1", "SPOUT1", "SPR", "SPTBN1", "SPTBN2", "SPTLC1", "SRSF3", "STARD3", "SUN2", "SURF4", "SUZ12", "SVIL", "TBC1D13", "TECR", "TERF2IP", "THUMPD3", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM8B", "TK1", "TKT", "TMEM165", "TMLHE", "TMTC3", "TMX1", "TMX2", "TMX3", 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0.0011293669878184 0.0056731852980481 0.0079620077053278 +Abnormal csf protein level 5 11 2.555569657464953 0.0106014139816013 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.0155575631698287 0.0538434207197609 0.0138407349238781 0.0105883475769395 +Sensory axonal neuropathy 4 17 2.547356808538931 0.0108542388342951 3.9975728155339807 14.679611650485436 0.7278248103953019 0.4694895664907109 2.2409459540492587 2.061969989484369 0.8093416738396336 0.3127535543746148 0.0087935329278829 0.031373049189738 0.0005695758393465 0.0119362160344991 +Arthritis 12 40 2.520569057532709 0.011716524535797 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0981576694070633 0.0201115001422002 0.1183910041975557 0.0021436695302957 +Proportionate short stature 7 32 2.5062910504919933 0.0122005144935406 8.20873786407767 34.116504854368934 0.7111768198576495 0.4559300049156646 3.388318218343798 3.7920483254309434 0.966379822462628 0.3393663702605685 0.0966324665930835 0.0837371519329494 0.0144872792095396 0.1482732403897816 +Abnormality of peripheral nerves 9 43 2.4923698216412675 0.0126893836639847 10.25 46.179611650485434 0.6405954271790926 0.5475676474607668 4.435418457508139 5.762430366840002 0.784998085911033 0.3389861349319225 0.0146537708834138 0.0183313093591291 0.0131613945624557 0.0310346728123828 +Segmental peripheral demyelination remyelination 1 5 2.486620680908415 0.0128962821334388 1.6601941747572817 4.737864077669903 1.1231406516527276 0.2457358043386077 1.1021021225411718 1.375663406058269 1.1869683790120098 0.2709829643602553 0.0573151884822011 0.0056684159955205 0.0323840811666381 0.1125747569923622 +Abnormality of the distal phalanges of the toes 1 5 2.485031916090924 0.0129539820165609 2.094660194174758 5.058252427184466 1.0467054837889296 0.2409661092181722 1.19191069217632 0.9786581135773657 1.170071232541671 0.254087308422285 1.0 0.1349531130589082 0.0491545726752397 0.1630814235328921 +Elevated pulmonary artery pressure 11 22 2.4819276545593163 0.013067380263749 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.3555919235953944 0.2107495506364678 0.0628592194430533 0.0667716397760765 +Oromandibular dystonia 3 5 2.4649525206024774 0.0137031408170802 1.730582524271845 4.956310679611651 1.1882502597012077 0.2382412593757527 1.131086190944388 1.1979083634266432 0.9893427275402558 0.2482274576089271 1.0 0.1265462710440741 0.0040998381065295 0.003721367796782 +Distal lower limb muscle weakness 4 17 2.463426446295032 0.0137616128248059 4.344660194174757 17.815533980582526 0.1186580396731779 0.5383160781021461 2.7593874427650213 2.6059959720089503 0.9262387077523402 0.2986056584700273 0.0239365913087713 0.0115248505447769 0.0061967751678044 0.0877145718471434 +Abnormality of the tarsal bones 8 26 2.4481764262585903 0.0143581330489266 7.135922330097087 26.50242718446602 0.598228998535255 0.5095033527659901 3.3211547403728976 3.593750499473341 0.86584218888204 0.3274398125512684 1.0 0.5440657264544094 0.0451247139786066 0.0162906747230869 +Abnormal metatarsal morphology 11 23 2.4471614751282105 0.0143986314688209 6.706310679611651 24.638349514563107 0.7721346669926398 0.4611221801551243 2.9696946625730853 3.9478131090337834 0.8523308608564429 0.3258568187536518 0.093603257631803 0.2676422850845579 0.1084258215337314 0.0686472570530836 +Decerebrate rigidity 3 5 2.417608095311445 0.0156228929554151 2.070388349514563 4.286407766990291 0.7483196612133007 0.2095871679116443 0.9590634816350864 0.5578301484347907 1.4826535249517825 0.245070013535738 0.0290719737908623 0.0563150378970086 0.0002598056683521 7.614857799780336e-05 +Hypergonadotropic hypogonadism 1 13 2.412489356026003 0.0158440000563633 3.5485436893203883 14.614077669902912 -0.0439616597189732 0.6010569255526399 2.5609223185949337 2.011881183589132 0.8070144224494777 0.2867397207010345 1.0 0.3404254693467198 0.2766090590544724 0.6247651003553614 +Disproportionate short limb short stature 10 23 2.410183299743922 0.0159445075590587 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.2849410889163232 0.4825947600252522 0.0057156172518009 0.005344696455789 +Increased cerebral lipofuscin 3 5 2.4079405773284908 0.0160427919980228 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 0.0479914252810258 0.0921025797166938 0.0227865880642579 0.0009118158302113 +Abnormal circulating amino acid concentration 14 54 2.405062704226025 0.0161696910648956 11.888349514563108 51.69660194174757 -0.7211284566914492 0.415539480862222 6.12785777945427 5.522037764680656 1.0841423731150537 0.3278509795234428 1.0 0.0150746255638078 0.0006080047307834 2.0157272190379912e-05 +Aplasia hypoplasia involving bones of the lower limbs 17 89 2.4008675726652404 0.0163562545156481 19.410194174757283 88.28155339805825 0.2455434370550195 0.7366360730888745 6.913416881109145 11.322215876065782 0.6022756981459902 0.2969807113615431 0.0531667526311392 0.3042853013015008 0.0906520978506483 0.1700337327436302 +Calcinosis 1 5 2.400834707340684 0.0163577235182765 1.5072815533980584 5.099514563106796 1.1513451038285936 0.2590169313384529 1.041584579038491 0.4030222683885372 0.953608514142629 0.2639318719258676 1.0 0.0921025797166938 0.0227865880642579 0.0817606313480972 +Bulbar signs 6 13 2.367388904576597 0.017914097415316 4.888349514563107 12.016990291262136 1.527818207801298 0.1656113111527082 2.218011046873564 1.4803576942139227 1.2783367300196684 0.2344360472575242 0.1457663642848915 0.0034893000144238 9.709596743557455e-05 0.0007105677029561 +Abnormality of skin pigmentation 35 126 2.342603901612817 0.0191497011697585 26.3373786407767 128.95145631067962 0.1990504083782209 0.7377192576079741 10.52829110144782 14.962820356630305 0.6200550523080489 0.2977060696441045 0.8509920253450844 0.8852714750053846 0.074262875834555 0.0104430337031806 +Abnormality of upper limb joint 21 118 2.3384549195311304 0.0193636616229988 22.174757281553397 112.72815533980582 0.5181453657197084 0.6203796408917344 7.717622231118391 13.742566693149987 0.824816154844266 0.3600833350084496 0.0939477265764656 0.1239689989821366 0.0021376043546424 0.0038318281001749 +Toxemia of pregnancy 1 5 2.3370651204731345 0.0194357982922823 1.4878640776699028 5.800970873786408 1.2181595126321945 0.2438445067902855 1.0938256996143263 0.5566883958063523 0.8280220660434614 0.2316195823412623 0.0573151884822011 0.1094892401774078 0.0323840811666381 0.1125747569923622 +Pericarditis 1 5 2.3355133643959545 0.0195166185706652 1.5412621359223302 4.808252427184466 1.0465356013883245 0.3273693330411259 1.0523881114446327 0.8152847226576512 0.8192491618381674 0.278983410545408 0.066549445548378 0.0077184558590264 0.0432719236791885 0.0277461310389573 +Flexion contracture of digit 17 74 2.318909887632569 0.0203999228948426 14.550970873786408 68.22572815533981 -0.2325397928866349 0.7179307730751237 6.6354318147415015 9.173622920062636 0.5984144074432136 0.2834984248928443 0.67972075728327 0.1782641205635585 0.0004131194362542 0.0037809265573523 +Muscle stiffness 6 19 2.306382368044582 0.021089276321401 5.109223300970874 19.216019417475728 1.2530133657268057 0.2695837776665858 2.5817154639007844 2.4582801786037667 1.0397164239726309 0.2961148999712332 0.0024333620388206 0.0018806372047711 0.0019598595015423 0.0047453897441578 +Foot dorsiflexor weakness 6 30 2.30637842339329 0.0210894965418795 6.871359223300971 31.803398058252423 0.5722811231484813 0.5519136473671545 3.234440738423893 3.8012118796735064 0.7842026565791261 0.3226099174033894 0.0508992589190798 0.034172513126223 0.0085914678921418 0.0670258998725707 +Neuronal loss in central nervous system 5 12 2.2817324985107086 0.0225051381554723 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.1373006943976843 0.0334071197556988 0.0054543168641633 0.0027845492980534 +Limited wrist movement 3 5 2.2768629917979184 0.0227944084732651 1.3519417475728157 5.033980582524272 0.5996596677114278 0.4085363950174713 1.0882965742387771 1.0765869657248284 0.9224773457089386 0.2739378776344282 1.0 0.0921025797166938 0.2159896916124382 0.3921885014959403 +Increased bone mineral density 7 25 2.271496600549873 0.0231169325278708 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.0060673937801388 0.0365585180593606 0.0357740016809835 0.0304896229948475 +Thoracic scoliosis 4 12 2.263207399227507 0.0236229073239522 2.895631067961165 11.815533980582524 0.7054864621280054 0.4260251550564725 1.907135385454388 1.092761468704903 0.8938736368000172 0.2999782404089314 0.1244478155008913 0.0274603336438859 0.0036949558723267 0.008785557350241 +Disproportionate short trunk short stature 3 5 2.258457999044549 0.0239171202891483 1.5218446601941749 4.983009708737864 0.4124275912660306 0.360786721341216 0.9306060741204804 1.0713400871945435 1.1869525657580595 0.284085703465065 1.0 1.0 0.082298412398385 0.0143001062154138 +Postural tremor 3 17 2.2551005448204813 0.0241270184622373 5.194174757281553 17.851941747572816 1.214872214945056 0.2487017685351703 2.341305968762478 2.2981463861426747 1.2391489410765593 0.2821199379659175 0.0163255968864409 0.0065760397653667 0.0150956780286917 0.1274755097437061 +Abnormal circulating branched chain amino acid concentration 2 6 2.2550454629590835 0.0241304752922546 1.949029126213592 5.395631067961165 -1.2148052932905906 0.2273464014421418 1.1255307395862653 1.1021956638296482 1.083092281843234 0.250832540326621 1.0 0.002465796513642 0.0007018811705627 0.0053031795330487 +Acquired abnormal hair pattern 2 5 2.2458743640419208 0.0247120563619018 1.4199029126213591 5.766990291262136 0.6620014283747138 0.3904282029890095 1.3075182117543094 1.3506839942536244 0.9640587931791604 0.2815607873033881 1.0 0.1515272625734178 0.0072626368836444 0.0465653262864464 +Sensorimotor neuropathy 8 31 2.238194009720352 0.0252084061307851 8.980582524271844 31.118932038834952 1.3016328701661894 0.3009249972125085 3.646997920951252 3.5836645053134393 1.2437208862143418 0.3260038325488978 0.0048225524960019 0.0045315560193572 0.0014029652894457 0.006476918487605 +Equinovarus deformity 1 5 2.227740642388565 0.0258978151211248 1.6019417475728157 5.201456310679611 0.5878066527272209 0.4188147239684637 1.2294114609421758 0.9881324031472178 1.0021081641648737 0.306259169635257 0.0479914252810258 0.0921025797166938 0.0227865880642579 0.0817606313480972 +Disturbance of facial expression 0 5 2.224796993520737 0.0260948693280891 1.3932038834951457 5.439320388349515 -0.3527804163950597 0.3903928157082794 1.0546947412718393 1.037504251609885 1.0930671067739652 0.2599408008496999 0.0802348466038066 0.1515272625734178 0.3388735835116871 0.5711774547855736 +Abnormal circulating lipid concentration 26 82 2.22305781095425 0.0262119019940285 21.0995145631068 75.44417475728156 1.321442689138656 0.3287247628796158 8.33534407984455 6.5596064623065375 1.4065018349702674 0.365722219395451 0.0100490737429994 0.0002510269571156 1.7389305417042723e-05 8.806190960704186e-07 +Abnormal corneal epithelium morphology 3 17 2.205472456808127 0.027420958489664 4.177184466019417 16.62621359223301 0.8116695621933796 0.4446326391054055 1.7953996864022932 1.7490891479802395 0.7696685494080681 0.3046964378924103 1.0 0.1100932826860655 0.0529987567153138 0.1573271124776855 +Male hypogonadism 2 9 2.201249915064086 0.0277183364097179 2.9393203883495147 7.871359223300971 -0.2891462930988354 0.6142321289128655 1.8311510317925173 1.3778606947945031 0.723361577462375 0.2895119666615631 1.0 0.2070995190727305 0.112413166150522 0.1083207684216986 +Broad phalanx of the toes 2 5 2.1994956074570946 0.0278427011283572 1.5604938271604938 5.439506172839506 0.5670705717196924 0.4763752885673162 1.212861020438932 1.4330903336087657 0.8595553173769842 0.3029593861447532 1.0 1.0 0.5524281428970466 0.2143350029099695 +Nephropathy 8 20 2.180194110943409 0.0292430759630524 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.2742474624411909 0.4672829604777532 0.7952575964607393 0.0946135485635064 +Atrophy degeneration involving the caudate nucleus 1 5 2.1693649534610917 0.0300549875138793 1.2888349514563109 4.283980582524272 0.3751529128205025 0.4147621281846377 1.0481475114547032 1.0836094304135666 1.1513114797047737 0.3142236199023666 1.0 0.1094892401774078 0.0323840811666381 0.1125747569923622 +Abnormal pupillary light reflex 2 5 2.1656281312016934 0.0303396149360644 1.4174757281553398 3.679611650485437 0.9517861806903368 0.2765165930815738 0.9113552465055588 0.9133698645011392 1.1632683567768367 0.2562066598516425 0.0015075035399645 0.0056684159955205 0.0323840811666381 0.018020673376298 +Slow pupillary light response 2 5 2.1656281312016934 0.0303396149360644 1.4174757281553398 3.679611650485437 0.9517861806903368 0.2765165930815738 0.9113552465055588 0.9133698645011392 1.1632683567768367 0.2562066598516425 0.000647621121882 0.002465796513642 0.0146338936924203 0.0053031795330487 +Impaired vibration sensation in the lower limbs 2 14 2.163089665608451 0.0305342838029072 3.5436893203883497 13.5752427184466 0.6952737045250533 0.4242336391370475 2.2993316843683766 2.2069327415111175 1.0005780794846004 0.3215228956981494 0.0155575631698287 0.0061250241039257 0.0665120453316815 0.2936288791787133 +Abnormality of the ribs 12 61 2.153447480990095 0.031283527416932 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.2643557331790067 0.312508620554065 0.0254352042923354 0.0397444216142391 +Aplasia hypoplasia of the breasts 2 9 2.1532202104426927 0.0313013760419635 2.2936893203883497 7.881067961165049 0.0206508184322712 0.5816562811855188 1.8756640197883692 1.3358139314511397 0.7947208508835064 0.2806094383959772 1.0 0.3076603852203092 0.2318289312745187 0.2801972283088816 +Dementia 11 55 2.1530888380675117 0.0313116973169407 17.021844660194176 58.19174757281554 0.9978727756866732 0.3214313161707923 5.814027938449679 5.568168011495494 1.793982160512653 0.3770196158976925 0.145012854682081 0.0020186844379805 0.0057370722617064 0.0342361314750581 +Hypoplasia of the musculature 3 5 2.1521343317763804 0.0313867758521424 1.412621359223301 5.393203883495145 0.6491558839366509 0.4339241341629252 1.0724420559765822 0.8594152602202743 0.8694942858597294 0.2925094147190523 0.0711332726649859 0.1349531130589082 0.0491545726752397 0.0334620993119388 +Wide cranial sutures 3 7 2.151765408128044 0.0314158356079221 2.0145631067961167 7.703883495145631 0.7152221419680245 0.3932675421341624 1.400340303092121 0.8783725385755785 0.8965275088954128 0.2767752142477642 1.0 0.1432798584585485 0.0553069748090555 0.0062633876942655 +Metaphyseal striations 3 6 2.1511628775703557 0.0314633459827917 1.300970873786408 5.247572815533981 1.010217520882931 0.3307806984352505 1.0528274594376033 0.9460541108309968 0.8938491735917876 0.283997233679671 0.0008300469730069 0.0031504918831051 0.018519525655472 0.0005688349419973 +Progressive gait ataxia 6 11 2.1494882250703142 0.0315957184992798 3.3810679611650487 11.0873786407767 0.9190295749650902 0.2658532875386696 1.7592835107251577 1.880439920211323 1.2434873962438642 0.2734996669217905 0.1070183553885475 0.0202898922491691 0.0170176746213231 0.0233101974365333 +Broad foot 5 11 2.148473983894696 0.0316761209703464 2.3300970873786406 9.016990291262136 0.256328891212772 0.5237546105785787 1.7131039762059068 1.5223903885177978 0.8992937610865464 0.290191176620823 0.1201219647894398 0.2223047329091382 0.0237046415332288 0.0351238878380088 +Abnormal motor nerve conduction velocity 3 18 2.1383050856628207 0.0324919900757141 4.25 20.558252427184467 0.4097033673292805 0.5168820746224434 2.874076466272354 3.062298910278382 0.8700343666746154 0.2942167990911473 0.1988423464133734 0.0693457394610891 0.0224343496689777 0.1732034237667374 +Abnormality of neutrophil morphology 2 5 2.1367569263038084 0.0326177672139809 1.3495145631067962 5.186893203883495 0.8052558850098389 0.4007759928981252 1.1613411887055554 0.6730044635900011 0.8443305889492255 0.2973774449831792 1.0 1.0 0.018519525655472 0.0076703518288617 +Abnormal circulating proteinogenic amino acid concentration 8 34 2.133041951628466 0.0329212849436797 8.5 32.19417475728155 -1.0078893392617716 0.3644384304499172 4.199803509042192 3.414157424741308 1.1366485391639345 0.33759537713931 1.0 0.1226746045160812 0.0039178524894254 0.0031780548629359 +Horizontal nystagmus 5 23 2.1280501777772143 0.0333329234950521 6.274271844660194 23.053398058252423 1.1086320165192889 0.2915732095622053 2.6115907074401723 2.1860242554539786 1.3408731048130669 0.3129960018850027 0.0286799036387023 0.0017566671607845 0.0093310290543298 0.0457670040656382 +Hand polydactyly 11 28 2.1257489356887573 0.0335241699348829 9.114077669902912 32.17718446601942 0.810453590544338 0.4452800586149166 3.6615419153480793 5.309376559579211 0.948384387998628 0.3474317696921568 1.0 0.7583477142273662 0.686044674574245 0.1720596118631594 +Anisocoria 0 5 2.124900719383969 0.0335948979410418 0.9174757281553398 4.461165048543689 0.5569455701691335 0.4690972952709908 1.195860756292305 0.6041495683308217 0.9122546461628256 0.3082539456267605 0.0290719737908623 0.0563150378970086 0.1358171161885085 0.2581989334031505 +Abnormality of the musculature of the lower limbs 2 24 2.118170308649266 0.0341606467830297 6.565533980582524 25.90776699029126 0.508988513486999 0.5486864479414023 3.113247057195523 3.357535773447294 0.8220902923092538 0.3269446155121387 0.0484634562358207 0.0318707386939593 0.249568173305376 0.6861788336422434 +Biliary cirrhosis 2 7 2.116991110241403 0.0342606022733356 1.9733009708737863 6.650485436893204 1.1218722294682368 0.279893930524248 1.1603338056285764 0.598683634692072 0.8535321112514973 0.2502325498718601 0.0573151884822011 0.1094892401774078 0.0025675639060761 0.018020673376298 +Neck muscle weakness 4 15 2.116159715842096 0.0343312260804118 4.206310679611651 15.46359223300971 0.939049769317174 0.3360301393876674 2.1919222801274123 2.3742417714011115 0.9901989764800458 0.2887083620559018 0.2222355866483168 0.08610744549237 0.0336895534920958 0.1000707214680032 +Abnormal tendon morphology 33 214 2.115994813682363 0.0343452486687592 39.83009708737864 210.66747572815535 0.186427012418248 0.8250793001687675 13.057574783009096 21.97689895783318 0.5249130695927144 0.2801943200265986 0.2942643036739734 0.0889692476433556 4.139112016737314e-06 0.000154172974124 +Abnormal intraocular pressure 2 5 2.1132761099822246 0.0345771422611993 1.7378640776699028 5.364077669902913 0.7975593383695336 0.3664160137723464 1.328998199598039 1.2081723635255046 0.9260288950993424 0.2857643490638551 1.0 1.0 0.3703176202019055 0.0618109910728358 +Neurofibrillary tangles 2 6 2.0999307002901166 0.0357349376701128 1.9878345498783456 4.347931873479319 0.5966090900062281 0.2642083372508564 1.0995898071170882 1.1496807364853057 1.4348037417662018 0.2714513638042118 1.0 0.0002902447274798 0.0040998381065295 0.0277461310389573 +Abnormal pupillary function 3 7 2.091478405542564 0.0364852002178679 1.7985436893203883 6.25 0.9459174425459445 0.2892194993230557 1.1928988171245156 1.7202745886032773 1.109204161812943 0.2732247962160634 0.0100088432903632 0.0354914601129098 0.0375621633755105 0.0612536211646263 +Abnormality of fundus pigmentation 4 5 2.089982551482592 0.0366193671242713 1.327669902912621 4.106796116504855 0.698602514723802 0.4086607308417097 0.9738879183169284 0.9493239429840492 0.960772634952198 0.2928039707147685 1.0 1.0 0.3547863423381785 0.0097510399506001 +Abnormal vascular physiology 18 49 2.0848029496846183 0.0370871908693544 12.74757281553398 50.021844660194176 0.816183607478715 0.4136638745601454 4.907827009322534 5.622165606934028 1.2216480011219424 0.371091913776798 0.5737510651666717 0.083711718614366 0.0555952198234099 0.0402129266597144 +Motor axonal neuropathy 5 18 2.075095097400736 0.0379777220251373 4.257281553398058 16.37378640776699 0.3055932101454106 0.6606056588139702 2.440917460083662 2.148852083035663 0.6415167723360936 0.2892196864974227 0.0100088432903632 0.0354914601129098 0.0375621633755105 0.0033138804057902 +Clonus 6 30 2.0743058242431056 0.0380509172511458 8.04611650485437 31.93446601941747 0.5828978309354407 0.490454230151838 3.78619227044226 4.424455038167712 0.8696948910263331 0.3203390008180061 0.3328373805982222 0.1862598674919939 0.0471541643629231 0.0449507103926583 +Abnormality of the alveolar ridges 4 6 2.0737131840290477 0.03810595605589 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.1330370821365251 0.031373049189738 0.0316151554384263 0.0498364179528963 +Abnormal joint morphology 61 265 2.0575766065364616 0.0396307941905564 52.30339805825243 266.1990291262136 0.2500788863693359 0.8078491493990106 14.864197165849184 27.339633008473005 0.6288365893380027 0.3047285664472046 0.071657022223046 0.1828148595068962 0.0129934055622759 0.0012564848032673 +Thin skin 7 25 2.053651256970534 0.0400094573648024 5.233009708737864 24.262135922330096 0.5619176829908993 0.56634777500469 2.7153067859181794 2.501305154648419 0.6915958695001003 0.3147007677784247 0.2597451867723493 0.1163398228410075 0.4330229721991795 0.0275888658736797 +Abnormal thoracic spine morphology 8 28 2.04827412089975 0.0405331472657852 6.558252427184466 27.104368932038835 0.8238927765093872 0.4398474942511601 2.7009535990178555 2.5649391710658156 0.8855000478727516 0.3360788168488923 0.0369748680428621 0.0216384292134882 0.0036158068957019 0.0028431464975424 +Clonic seizure 1 5 2.046129301764854 0.0407436507792386 1.8131067961165048 6.669902912621359 0.6623037513988556 0.3539209052149137 1.4095799340712598 1.43559702755526 1.0696389563271094 0.2888576403054313 0.0981765691424607 0.1837383274168749 0.4002719515071794 0.2715157705871365 +Impaired tactile sensation 2 7 2.0448808223224257 0.0408666090478835 2.0800970873786406 7.844660194174757 0.3974848446712213 0.5051291165171002 1.725280894617257 1.4698080024763955 0.8897962544432779 0.3006087956437986 0.1026081339138497 0.191600110602388 0.0970188007029606 0.088385561156941 +Abnormal auditory evoked potentials 3 9 2.043424784596573 0.0410104060683691 2.837378640776699 8.45388349514563 0.8113355275163785 0.2966376606156203 1.5470802196866602 1.3128600166506037 1.1722229382642326 0.2813987538538041 0.0937235599037543 0.1758008751515455 0.082298412398385 0.0143001062154138 +Loss of speech 5 19 2.03657960894625 0.0416921879172464 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.1868885334554594 0.0075361578498098 0.0031662335838307 0.0150707717640174 +Cupped ribs 1 6 2.0259415091142707 0.0427707788948803 1.577669902912621 6.0 0.5801603501469451 0.4766240977970409 1.475129221842277 1.23264653316681 0.9086766247812612 0.313155017995867 0.0015075035399645 0.0056684159955205 0.0323840811666381 0.1125747569923622 +Abnormality of femur morphology 19 65 2.024540380254413 0.0429145815599398 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.2479282812723955 0.2888062349103493 0.0074135417096035 0.0139459099561602 +Ankylosis 0 5 2.022233807311804 0.0431522032318105 1.7160194174757282 5.099514563106796 0.776290643053947 0.3289690792318075 1.1013829257517682 0.4264322039260138 1.078831323421012 0.282224813150681 1.0 0.1265462710440741 0.2887519731811417 0.5020158400168588 +Hypoglycemic seizures 5 7 2.0219780650130685 0.0431786179863775 2.4854368932038833 6.856796116504855 0.9058299307950756 0.3166741060128459 1.3942606188234674 0.5840745955687526 1.0191247609873073 0.2803355691671325 1.0 1.0 0.0376759114543004 0.0027630263410089 +Ventricular preexcitation 3 6 2.0148425549231583 0.0439211485980015 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 1.0 0.1677870330809631 0.0752233407476578 0.0118865434534573 +Scarring 13 30 2.0098955931690856 0.0444422402761361 7.41747572815534 30.87378640776699 -0.1258492688784176 0.6582841673370581 3.825119509129044 3.6852622033956304 0.7192518810653888 0.2892438224654526 0.4047844567784328 0.6391647109532668 0.0406706140168594 0.0048014262518894 +Hypopigmentation of the skin 15 48 2.009567333779308 0.044477001499755 10.74757281553398 47.849514563106794 0.1707325332420539 0.6590834799133349 5.239355267906412 6.913591142293391 0.7758816324812914 0.3207839249753909 0.538277640080983 0.7809139112323245 0.3211392325223598 0.0194006675776902 +Emg neuropathic changes 4 27 2.002435603532946 0.0452379025056162 6.915048543689321 24.58252427184466 0.5887299592537784 0.4208819793990807 3.046574831105746 2.544837804909062 1.1306803597402475 0.3318248802653038 0.0013622028220488 0.0091243340822671 0.0224343496689777 0.0655768501043339 +Limited hip movement 2 13 1.997754703900397 0.0457432602959924 3.4611650485436893 14.42233009708738 0.4006176539546613 0.5357270610058099 1.852824294411875 2.000312210526048 0.7577897012425846 0.2739986193635235 1.0 0.3593428278464597 0.0980165262967078 0.3878167330330442 +Muscle hypertrophy of the lower extremities 0 6 1.995347965897787 0.0460049418535573 2.0558252427184467 8.055825242718447 0.5668750819760063 0.4584615762503552 1.6203469748712638 1.290100488501096 0.8942414668325795 0.296643114491846 0.1287528218161406 0.2372212797486779 0.494366254766713 0.7522555648072834 +Abnormality of the metaphysis 16 49 1.9912891571709332 0.0464491068188637 9.87621359223301 51.49514563106796 0.3562011438392169 0.6166342982450355 4.530020385411355 8.226317920685393 0.7780483709827255 0.3214835918572445 0.0414674769679191 0.1918302178058925 0.0134347740712361 0.0797951006545679 +Babinski sign 15 84 1.989596080010204 0.046635448325907 19.08009708737864 87.19902912621359 0.4494221734255122 0.5751659127226604 6.9223075443198026 7.569689110667714 0.8530342054419842 0.3513302291959216 0.0844023186954509 0.052431950334134 0.0005641917966459 0.0512886993951487 +Abnormal caudate nucleus morphology 4 11 1.9873248858152128 0.0468864056209623 2.8519417475728157 10.133495145631068 0.4630014218675518 0.4635627378613905 1.7037711217888412 1.7774598482419672 0.9891574305728495 0.3131768373752813 1.0 0.1837383274168749 0.0895680133917324 0.017002584405276 +Abnormal circulating metabolite concentration 73 342 1.987283987590796 0.0468909350950386 69.69660194174757 340.378640776699 0.1675785411628017 0.7818742837094025 21.975221882900627 30.626822594421736 0.6727942561101089 0.3183181726027206 0.0160819358113511 0.0017637680513581 2.225051202748249e-05 3.08736039637423e-07 +Osteoarthritis 3 8 1.9797868347561856 0.0477274863246315 3.783980582524272 10.466019417475728 1.011181157871384 0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.1287528218161406 0.0293903981750984 0.1448451451272836 0.0446088038944012 +Abnormal spermatogenesis 1 11 1.9727782360251973 0.0485208338197677 3.4902912621359223 13.310679611650484 0.2028210856104466 0.5561438428576214 2.1080987874600754 2.5543761277865236 0.8285113815997247 0.2817588245662891 1.0 0.4775398588675821 0.4812926628356874 0.6382073330630182 +Profound sensorineural hearing impairment 0 5 1.9700268117590127 0.0488352978108381 0.9174757281553398 4.160194174757281 0.513692147830608 0.4967944551210621 0.9744231237856372 0.7264543238402954 0.875985645396128 0.3008833773673707 0.0242848323540905 0.0471521402185075 0.1145296834007133 0.2203285200495684 +Abnormal platelet volume 5 8 1.9672379206971704 0.0491557881745541 2.3228155339805827 8.118932038834952 0.3570188357315436 0.5697375193447283 1.7626557178202784 0.6176457221577161 0.7895451993814145 0.3017943720876272 1.0 1.0 0.2532529321952443 0.018020673376298 +Limb joint contracture 18 104 1.9671562366483608 0.0491652015840682 21.16747572815534 100.42233009708738 0.6687590042181877 0.5853612155895958 7.458858708924721 11.434332835202127 0.8235264349573469 0.3682957054317731 0.1682346394206446 0.059540268273496 0.0006009144649694 0.0036289631225664 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c181cc3496bdfc009e8a2750376aceed3f92a186 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 4577, + "title": "Average number of proteins per term", + "value": 22.94931177627267 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..426f7ed588afb1b239633fe38c4f9810bb45b38c --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..36e715fa0c19882b695913cd231b906708fc5177 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1743 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vascular tortuosity 0.9682329583057584 4.112770152116325 3.9093957085345465e-05 0.163841039029518 0.0010109350307163 2 P05067 1 +Hypoplastic iliac wing 0.9434149569821316 3.999823769632621 6.338967019514641e-05 0.251843962618283 0.0013308922957944 2 Q7RTS9 1 +Percussion myotonia 0.9324950363997372 3.949619263180158 7.827560217088525e-05 0.3011236539878364 0.0015245422601538 2 P49773 1 +Narrow foot 0.9291859695565856 3.934343366449388 8.342445095177453e-05 0.3174023191408228 0.0015778252562242 2 P55263 1 +Corneal scarring 0.92422236929186 3.911374611340173 9.177229815549026e-05 0.3429933139663935 0.0016935435461881 2 P09884 1 +Hyporeflexia of upper limbs 0.9212442091330268 3.897561565748908 9.716612498866796e-05 0.3590161143614098 0.001739509212319 2 Q9NR77 1 +Abnormality of the glenoid fossa 0.9182660489741904 3.883724555493005 0.000102868438065 0.3755306684306346 0.0017568240336708 2 Q7RTS9 1 +Agenesis of cerebellar vermis 0.916611515552616 3.876026936083932 0.0001061759354765 0.384913922476422 0.0017866443260157 2 O43924 1 +Stuttering 0.9146260754467246 3.866779965168413 0.0001102818456906 0.3963663728795422 0.0018156834810286 2 Q9Y4W2 1 +Nail pits 0.91429516876241 3.865237759115761 0.0001109810354789 0.3982952415518047 0.0018206458759389 2 Q9Y6K9 1 +Hyperesthesia 0.9070152217074808 3.8312334078375176 0.0001275024772735 0.44212259526618 0.0019649119140776 2 P07602 1 +Bilateral tonic clonic seizure with focal onset 0.9070152217074808 3.8312334078375176 0.0001275024772735 0.44212259526618 0.0019649119140776 2 P07602 1 +Alveolar ridge overgrowth 0.9033752481800156 3.814176557921425 0.0001366377598732 0.4649706944443756 0.00203710432228 2 Q15392 1 +Tongue nodules 0.9033752481800154 3.814176557921425 0.0001366377598732 0.4649706944443756 0.00203710432228 2 O43924 1 +Abnormality of the phalanges of the hallux 0.9027134348113834 3.811071375464748 0.0001383658055178 0.469186269579311 0.0020429041672748 2 Q6DKJ4 1 +Broad hallux phalanx 0.9027134348113834 3.811071375464748 0.0001383658055178 0.469186269579311 0.0020429041672748 2 Q6DKJ4 1 +Prominent calcaneus 0.9027134348113848 3.811071375464748 0.0001383658055178 0.469186269579311 0.0020429041672748 2 Q7RTS9 1 +Peroneal muscle atrophy 0.9889153140783056 3.785275313213299 0.0001535385034352 0.5048030342782247 0.0022178707733414 3 Q9NR77 1 +Sea blue histiocytosis 0.9625951671631904 3.671283687990994 0.0002413352837422 0.6686979903027852 0.0030097863588237 3 P61916,O15118 2 +Somatic mosaicism 0.9616751980054106 3.667269657713687 0.0002451542219812 0.6744399785697079 0.0030491056358916 3 P00813 1 +Giant platelets 0.8659827928524186 3.636798051379814 0.0002760481864885 0.7173785675321969 0.0033425199723755 2 Q14739 1 +Prominent sternum 0.951009599470374 3.62058462583431 0.0002939380883719 0.7396041731550578 0.0034584951940321 3 O95831,P16278 2 +Abnormally shaped carpal bones 0.8587028457974881 3.601796456321203 0.0003160257651599 0.7646492991006775 0.0036526513311547 2 Q7RTS9 1 +Fractures of the long bones 0.8530774321641339 3.574642929693584 0.0003507061886045 0.7992035889819114 0.0040129555631076 2 Q13126 1 +Patchy alopecia 0.9394648117821256 3.5697398019721684 0.0003573359806743 0.8052072428581466 0.0040583791154998 3 O75844 1 +Ketotic hypoglycemia 0.8461283917935176 3.5409705728790235 0.0003986580383823 0.8387858454892982 0.0043444234325619 2 Q13423 1 +Hypomelanotic macule 0.8431502316346823 3.5264953453542827 0.0004210985670951 0.8545283507009576 0.0045137427203619 2 P49815 1 +Reticular hyperpigmentation 0.8431502316346817 3.5264953453542827 0.0004210985670951 0.8545283507009576 0.0045137427203619 2 P09884 1 +Abnormal proportion of double negative alpha beta regulatory t cell 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Burkitt lymphoma 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Increased b cell count 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Coombs positive hemolytic anemia 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Follicular hyperplasia 0.8408338848444745 3.5152183907261008 0.0004393924913932 0.8662176955230168 0.0046126133786854 2 Q05655 1 +Buphthalmos 0.8405029781601613 3.5136060763904333 0.0004420678651815 0.8678466090759317 0.0046169309411476 2 Q86XI2 1 +Metaphyseal cupping 0.924197285666992 3.5019945632822873 0.000461789041644 0.8792576828435792 0.0047618530619926 3 O95831,Q14739 2 +Decreased circulating igg subclass level 0.8289212442091377 3.456965700895848 0.0005462943762613 0.9180029971757436 0.0054474713728714 2 P00813 1 +Abnormality of the leydig cells 0.8269358041032471 3.447214787282163 0.0005663980914458 0.9252150418326406 0.0056234361486936 2 Q13423 1 +Mild short stature 0.9105592952972384 3.4409854890398535 0.0005795996156376 0.929602429534386 0.0057420507376054 3 Q13555 1 +Long neck 0.819655857048315 3.411357463314846 0.0006464028761121 0.9481573751983504 0.0061127809172839 2 Q15125 1 +Abnormality of the 5th metacarpal 0.8196558570483166 3.411357463314846 0.0006464028761121 0.9481573751983504 0.0061127809172839 2 Q14739 1 +Cor pulmonale 0.8196558570483163 3.411357463314846 0.0006464028761121 0.9481573751983504 0.0061127809172839 2 P06753 1 +Aplasia hypoplasia of the 5th metacarpal 0.8196558570483166 3.411357463314846 0.0006464028761121 0.9481573751983504 0.0061127809172839 2 Q14739 1 +Patchy changes of bone mineral density 0.901313360297432 3.3993545927715836 0.0006754508439941 0.9546154288635124 0.0063160732290506 3 Q13126 1 +Large placenta 0.898336228237607 3.3859028671749356 0.0007094449008029 0.9611591086174088 0.0064172516027174 3 O75844 1 +Retrocollis 0.8925860887286988 3.3598566559418512 0.0007798292254697 0.9718630270096844 0.0069985850293624 3 Q99720 1 +Flaring of rib cage 0.8915641628522992 3.355218664921746 0.0007930227331476 0.9735131001737688 0.0071030627194064 3 P16278 1 +Abnormality of lens shape 0.8074123097286582 3.350679937133865 0.000806134170896 0.975057050625342 0.0071100170622265 2 Q01968 1 +Elevated diastolic blood pressure 0.7981469225678413 3.304447660066533 0.0009516374329507 0.987192423173186 0.0081262024824921 2 P42892 1 +Elevated systolic blood pressure 0.7981469225678413 3.304447660066533 0.0009516374329507 0.987192423173186 0.0081262024824921 2 P42892 1 +Elevated mean arterial pressure 0.7981469225678413 3.304447660066533 0.0009516374329507 0.987192423173186 0.0081262024824921 2 P42892 1 +Hyperketonemia 0.7961614824619476 3.2945051659824425 0.0009859513237016 0.9890555776049572 0.0083568503862634 2 Q92947 1 +Reduced vital capacity 0.7941760423560603 3.284550042423352 0.0010214535674952 0.9906985255830048 0.008578335740231 2 P06753 1 +Shoulder girdle muscle atrophy 0.7941760423560603 3.284550042423352 0.0010214535674952 0.9906985255830048 0.008578335740231 2 P06753 1 +Elevated alkaline phosphatase of bone origin 0.7941760423560575 3.284550042423352 0.0010214535674952 0.9906985255830048 0.008578335740231 2 Q96NT0 1 +Premature osteoarthritis 0.7888815354070174 3.2579410534277193 0.0011222371498735 0.9941385822461044 0.0092883895749934 2 Q14807 1 +Amelogenesis imperfecta 0.7872270019854442 3.2496071806580806 0.0011556452013821 0.9949705606958728 0.0095304289850918 2 Q9HC07 1 +Increased c peptide level 0.7855724685638694 3.2412644352430666 0.0011900074015813 0.9957032967463664 0.0097785706948616 2 P40939 1 +Complex febrile seizure 0.7779616148246218 3.2027729912951415 0.0013611122715517 0.9980385169898328 0.0109799919929063 2 Q9H9E3 1 +Abnormality of the proximal phalanx of the thumb 0.774983454665789 3.1876595079781587 0.0014342932414126 0.9985974630400808 0.011357716550079 2 O60828 1 +Confetti like hypopigmented macules 0.7749834546657896 3.1876595079781587 0.0014342932414126 0.9985974630400808 0.011357716550079 2 P49815 1 +Symphalangism of middle phalanx of finger 0.774983454665789 3.1876595079781587 0.0014342932414126 0.9985974630400808 0.011357716550079 2 O60828 1 +Widened cerebral subarachnoid space 0.8540644703111304 3.183113435832716 0.0014570052071447 0.9987361286036776 0.0114734327296259 3 Q9BV10 1 +Flattened epiphysis 0.8526872255777987 3.1767205175059687 0.0014895050196359 0.9989110559852044 0.0115354728847272 3 O95831 1 +Mixed demyelinating and axonal polyneuropathy 0.8511559144536498 3.169606365369879 0.0015264557715446 0.9990807255660492 0.0118016690310132 3 Q9Y6X9 1 +Sensory neuropathy 0.621287874093952 3.14291118801925 0.0016727658512118 0.9995299446044144 0.0126759094387365 34 P00846,O95831,P00403,Q8IV08,P26358,Q15067,P40939,O60220,P49773,Q9Y6X9 10 +Renal cortical microcysts 0.7637326273990777 3.130299693985749 0.0017462804694428 0.9996644409510778 0.0131243443491621 2 Q6PGP7 1 +Abnormal serum interleukin level 0.8411122144985128 3.1227858035148204 0.0017914807439496 0.9997272516187418 0.0133761947227691 3 Q05655,P09884 2 +Elevated serum acid phosphatase 0.840781198278698 3.121237973933032 0.0018009243637742 0.999738809907992 0.0134029769316985 3 P07602,Q9NZJ7 2 +Contractures of the joints of the upper limbs 0.4801246441070523 3.106795277602357 0.0018912732403946 0.9998274034427168 0.0139618671311067 75 Q9Y6K9,P50542,Q9BUB7,Q7LGA3,O75530,Q9NR77,Q15392,O95425,P06753,Q99720,P42892,O60828,Q9Y619,P49773,O75844,Q9Y6X9 16 +Osteolytic defects of the distal phalanges of the hand 0.9136902022263677 3.088608745696504 0.0020109608170941 0.9999003089541484 0.0144492427940974 4 O75844 1 +Eversion of lateral third of lower eyelids 0.754136333553941 3.081041416505097 0.0020627795408132 0.999921396401232 0.0147520968098472 2 P60953 1 +Toe walking 0.704529279933335 3.0767987391096714 0.0020923652188646 0.9999313705379536 0.0147833611188577 22 Q13057,O95831,P15289,Q8ND04,Q99720,P06753,P07602,O43681,P40939,P55072,Q9NZJ7,Q9Y6X9 12 +Short middle phalanx of finger 0.831181727904668 3.0762184708048403 0.0020964417514031 0.9999326418120228 0.0147833611188577 3 Q8IWS0,Q9UHX1 2 +Joint hemorrhage 0.7528127068166828 3.0742228403012897 0.002110517232182 0.999936853009306 0.0148384598643581 2 P49257 1 +Psoriasiform dermatitis 0.830516123102967 3.0730873942389976 0.0021185643345336 0.9999391412527596 0.0148721916551539 3 Q15800 1 +Erlenmeyer flask deformity of the femurs 0.8283051002027493 3.062677593601438 0.0021936626509102 0.9999568756477788 0.015261717118379 3 P07602 1 +Cerebral hamartoma 0.824561403508758 3.045020445909751 0.0023266449239689 0.9999765692512608 0.0161056554728218 3 P49815,O43924 2 +Abnormal lower limb bone morphology 0.3887171640978213 3.036279962837822 0.0023951685642915 0.9999828898082164 0.0163970592438344 160 O96028,Q15125,Q5SRE5,Q7RTS9,P49773,Q9NZJ7,O95831,P98175,Q13555,Q9UPW6,P00813,Q7LGA3,Q15392,O75530,P07602,Q08J23,Q9BV10,O43924,Q9Y487,P40939,O15111,Q9UHX1,O75844,Q9Y4W2,P50542,Q9H7D7,P16278,O00116,Q14739,Q9Y619,Q9UGU0,Q10713,Q6DKJ4,Q69YQ0 34 +Joint contracture of the hand 0.537043225182975 3.035638612099438 0.0024002686679853 0.9999832855265588 0.0163970592438344 50 Q9Y6K9,P50542,Q9BUB7,O75530,Q9NR77,Q15392,O95425,P06753,P42892,O60828,Q9Y619,P49773,O75844,Q9Y6X9 14 +Abnormal foot bone ossification 0.819927176431636 3.0231083797889657 0.0025019262208136 0.9999895160540244 0.0169441663222265 3 Q15125,Q14739 2 +Myokymia 0.8149957868098244 2.999724427310355 0.0027022396659492 0.9999958187151184 0.0178472596696246 3 P49773 1 +Polar cataract 0.8921805546651318 2.9952234538835363 0.0027424385543945 0.999996523152392 0.0180866588810721 4 Q7LGA3,P08670 2 +Absence of secondary sex characteristics 0.8907379120925556 2.9889208119339963 0.0027996468071571 0.9999973260513944 0.0182535376586301 4 Q9BZH6 1 +Impacted tooth 0.810469907086491 2.9782024269913845 0.002899444220739 0.9999983087326116 0.0187971050967743 3 O75844 1 +Limitation of movement at ankles 0.810469907086491 2.9782024269913845 0.002899444220739 0.9999983087326116 0.0187971050967743 3 O75844 1 +Abnormal serum insulin like growth factor 1 level 0.8086082705272943 2.96933276198272 0.0029844721525364 0.9999988552834758 0.0193037106732651 3 Q9BV10 1 +Abnormal libido 0.8862139048921724 2.969123909417443 0.0029865014279304 0.9999988658979148 0.0193037106732651 4 Q9BZH6 1 +Angina pectoris 0.8084838097677222 2.9687394215753677 0.002990240521596 0.9999988851987966 0.0193037106732651 3 O75844 1 +Abnormal number of granulocyte precursors 0.8065402730953573 2.959468257696026 0.0030817044756368 0.9999992674540744 0.0197548478781369 3 Q07020 1 +Aplasia hypoplasia involving the musculature of the upper limbs 0.729318332230315 2.9521980696016827 0.0031552046871303 0.999999477270979 0.0200261199063254 2 P21333 1 +Edema of the dorsum of feet 0.729318332230315 2.9521980696016827 0.0031552046871303 0.999999477270979 0.0200261199063254 2 Q9Y263 1 +Edema of the dorsum of hands 0.729318332230315 2.9521980696016827 0.0031552046871303 0.999999477270979 0.0200261199063254 2 Q9Y263 1 +Abnormal sweat gland morphology 0.8819382940832992 2.95036876120165 0.0031739485441721 0.9999995203770766 0.0200928941724427 4 Q9Y6K9,O75844 2 +Abducens palsy 0.8807947019867509 2.9453448748161177 0.0032259486585486 0.99999962225036 0.0202818228161773 4 P07602,Q9NZJ7,O00170 3 +Secundum atrial septal defect 0.7276637988087398 2.9435330389834715 0.00324489186168 0.9999996537201802 0.0203450274669996 2 P34897 1 +Flat forehead 0.8016340254150053 2.9360159101475425 0.0033245727052646 0.9999997598302254 0.0207310208065344 3 Q13555 1 +Cortical cataract 0.8013902681231365 2.934848917832491 0.0033371012848084 0.9999997732583829 0.0207808334429501 3 Q01968,Q99797 2 +Laryngeal cleft 0.7246856386499065 2.927911944862389 0.0034124667419521 0.9999998395960444 0.0211924834164383 2 Q69YQ0 1 +Gingival fibromatosis 0.8741319334428267 2.916011900057891 0.003545369780584 0.9999999128810398 0.0217814194439372 4 Q15392 1 +Angiokeratoma 0.7954319761668256 2.9062700615143036 0.0036576561458019 0.9999999479875966 0.022298730081421 3 P06280,P16278 2 +Menorrhagia 0.7933193628540853 2.896112225028871 0.0037781725964154 0.999999970101152 0.0228739364732717 3 P49257 1 +Opportunistic infection 0.792200636399967 2.8907279245982336 0.0038435071049316 0.9999999778543748 0.0229957281297674 3 P00813 1 +Absence of pubertal development 0.9314100643578088 2.8605815458092008 0.0042286478727124 0.9999999962276164 0.0246868894303636 5 Q9BZH6 1 +Cerebellar cortical atrophy 0.7114493712773042 2.858108496988924 0.0042617464569416 0.999999996760014 0.0248307498661775 2 Q9Y263 1 +Anterior rib cupping 0.8607706509985078 2.856862861350313 0.0042785065079578 0.9999999970002492 0.0248307498661775 4 O95831 1 +Spondylolysis 0.7107875579086742 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 P21333 1 +Knee dislocation 0.7107875579086741 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 Q9Y2D4 1 +Failure of eruption of permanent teeth 0.7107875579086741 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 A6NHR9 1 +Cervical kyphosis 0.7107875579086742 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 Q8NCH0 1 +Abnormal cervical curvature 0.7107875579086742 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 Q8NCH0 1 +Capitate hamate fusion 0.7107875579086742 2.854602098278381 0.0043090778749204 0.99999999739352 0.0248307498661775 2 P21333 1 +Molar tooth sign on mri 0.8599746695181371 2.853325331269647 0.0043264304528185 0.9999999975933552 0.0248457618350696 4 Q96KP1,O43924 2 +Megalencephaly 0.783929959068711 2.850808792726629 0.004360818426778 0.999999997945252 0.0250118620794024 3 P49815 1 +Diaphyseal thickening 0.7828673695730111 2.8456655943697755 0.0044318709483899 0.9999999985178264 0.0253875761336429 3 Q14739 1 +Finger swelling 0.707147584381209 2.835289114714606 0.0045784231234837 0.9999999992444392 0.0260460035964178 2 Q01968 1 +Biliary tract abnormality 0.6218460683346271 2.834835546653704 0.0045849280826568 0.9999999992667036 0.0260460035964178 27 O96028,P14174,P50542,Q14108,P09601,O43681,P07602,Q14739,Q10713 9 +Agyria 0.7800062959989642 2.831800788260715 0.0046286676235332 0.9999999994003012 0.026252059123806 3 Q00535 1 +Fasting hypoglycemia 0.7794518633668508 2.829111212885241 0.0046677475436172 0.9999999994989412 0.0264251104883825 3 O43772 1 +Cataplexy 0.8536423841059554 2.8251275606395283 0.0047261796546236 0.9999999996170068 0.0266729029336773 4 P61916,O15118,P26358 3 +Action tremor 0.496931115327916 2.8132661201324014 0.0049041046502931 0.9999999998310312 0.0276089630804324 53 P00846,Q9BUB7,Q14108,Q9NR77,Q5JRX3,Q99720,P07602,O43681,Q6PJG6,P41440 10 +Abnormal peripheral nervous system physiology 0.5186678853522875 2.810544981323067 0.0049457675116379 0.999999999860498 0.027707194492983 49 O95831,Q9NR77,Q15125,Q99720,P07602,O43681,O60220,O15269,P31930,Q9Y619,Q9Y6X9 11 +Abnormal biliary tract morphology 0.6406612901839865 2.7942803543586057 0.0052015362603341 0.999999999956989 0.0289980894805717 24 P14174,P50542,Q14108,P09601,P07602,O43681,Q14739,Q10713 8 +Widely patent fontanelles and sutures 0.8465372018034403 2.7933700227295755 0.0052161986875631 0.9999999999597948 0.0290444542493633 4 O75844 1 +Rhizomelia 0.759094369261206 2.7911185605336284 0.0052526228056415 0.9999999999659984 0.0291993405628251 14 O75718,Q15392,Q15125,O00116,Q7RTS9,Q14739,Q9UBM7,Q9BV10 8 +Short lingual frenulum 0.8459774542635053 2.790862834018304 0.0052567744425973 0.9999999999666418 0.0291993405628251 4 O75844 1 +Intracellular accumulation of autofluorescent lipopigment storage material 0.6975512905360738 2.7841465896849185 0.0053668772465642 0.999999999979901 0.0295598040403425 2 O75503 1 +Nuclear cataract 0.8423054395818965 2.774396019705931 0.0055304310180785 0.9999999999905314 0.0302220534966855 4 P08670 1 +Breast aplasia 0.8422910401018749 2.7743313804191803 0.0055315301097202 0.9999999999905792 0.0302220534966855 4 Q9Y6K9 1 +Pleuritis 0.7675651495684291 2.77122969960188 0.0055845016508491 0.9999999999926176 0.0302220534966855 3 Q9NZ08 1 +Neuroinflammation 0.7675651495684291 2.77122969960188 0.0055845016508491 0.9999999999926176 0.0302220534966855 3 Q9NZ08 1 +Orchitis 0.7675651495684291 2.77122969960188 0.0055845016508491 0.9999999999926176 0.0302220534966855 3 Q9NZ08 1 +Pulmonary embolism 0.7675651495684291 2.77122969960188 0.0055845016508491 0.9999999999926176 0.0302220534966855 3 Q9NZ08 1 +Multiple myeloma 0.6949040370615535 2.769980218509982 0.0056059697222385 0.999999999993312 0.0302220534966855 2 Q01130 1 +Abnormal substantia nigra morphology 0.6949040370615536 2.769980218509982 0.0056059697222385 0.999999999993312 0.0302220534966855 2 Q15813 1 +Spontaneous recurrent epistaxis 0.6949040370615536 2.769980218509982 0.0056059697222385 0.999999999993312 0.0302220534966855 2 P35579 1 +Disproportionate short stature 0.6118291651924918 2.7634555954350195 0.0057192873711233 0.9999999999960304 0.0307084179629209 27 Q7LGA3,O75718,Q14807,Q15125,Q15392,P16278,Q9UBM7,O00116,Q7RTS9,Q14739,Q9UHX1,Q6DKJ4,Q9BV10 13 +Ectodermal dysplasia 0.7659315945695866 2.7632424435393097 0.0057230239288554 0.999999999996098 0.0307084179629209 3 Q9Y6K9 1 +Dilation of virchow robin spaces 0.6932495036399786 2.761113424854198 0.0057604666702784 0.9999999999967156 0.0308370245027652 2 P43034 1 +Branchial cyst 0.6932495036399791 2.761113424854198 0.0057604666702784 0.9999999999967156 0.0308370245027652 2 Q9UHX1 1 +Hyperkeratotic papule 0.6929185969556635 2.7593388818288216 0.0057918439333706 0.9999999999971576 0.0309326367363329 2 Q9H488 1 +Dyspareunia 0.8382808768186156 2.756309605683027 0.0058457634697086 0.9999999999977824 0.0311842184159167 4 Q9BZH6 1 +Abnormality of pulmonary circulation 0.6176043516749858 2.753457968618428 0.0058969341673562 0.9999999999982478 0.0314205677345629 26 P21333,P00403,Q9Y6K9,P20674,P49327,P11047,O75531,Q69YQ0,Q8IZA0,Q14108,Q9NZ08,P51970,O75844 13 +Decreased light and dark adapted electroretinogram amplitude 0.7578614022164625 2.7236663890665276 0.0064561685377262 0.9999999999998668 0.0338486636851924 3 P50897 1 +Deep set nails 0.7568765717358005 2.718823451005551 0.0065514566251767 0.999999999999914 0.0343089439055309 3 O75530 1 +Female hypogonadism 0.8972597126029248 2.7180052679720292 0.0065676792454194 0.9999999999999202 0.0343409276218139 5 Q9BZH6,O75844 2 +Abnormal placental size 0.8297325872630662 2.7177589639992057 0.0065725699359207 0.999999999999922 0.0343409276218139 4 O75844 1 +Breast hypoplasia 0.8928317597658134 2.699334698942308 0.0069478261843687 0.999999999999986 0.0360546490315824 5 Q9Y6K9,Q9BZH6 2 +Aplasia hypoplasia of the 4th metacarpal 0.752618391153159 2.6978501640094303 0.0069788844660712 0.999999999999988 0.0360930555945851 3 Q14739 1 +Sclerosis of skull base 0.752618391153159 2.6978501640094303 0.0069788844660712 0.999999999999988 0.0360930555945851 3 Q14739 1 +Abnormality of the 4th metacarpal 0.752618391153159 2.6978501640094303 0.0069788844660712 0.999999999999988 0.0360930555945851 3 Q14739 1 +Generalized clonic seizure 0.8229671829041934 2.687118383362151 0.0072071404252183 0.9999999999999958 0.0368372044296411 4 P07602 1 +Abnormal nerve conduction velocity 0.5406497135861488 2.6865528962877896 0.0072193516218894 0.999999999999996 0.0368372044296411 41 O95831,Q9NR77,Q99720,P07602,O43681,O15269,P31930,Q9Y619,Q9Y6X9 9 +Abnormality of the calf musculature 0.7496001793380668 2.6823019063356246 0.0073117440703376 0.9999999999999974 0.0370197484623178 13 Q9NR77 1 +Onychogryposis 0.746732014060904 2.668767395962926 0.0076130152666684 0.9999999999999992 0.0381651378702536 3 Q9Y6K9 1 +Progressive peripheral neuropathy 0.8178807947019803 2.664005920015569 0.0077216203795129 0.9999999999999996 0.0385407377066857 4 P07602,O43681,Q9NZJ7 3 +Vegetative state 0.8178807947019803 2.664005920015569 0.0077216203795129 0.9999999999999996 0.0385407377066857 4 P07602,O43681,Q9NZJ7 3 +Blurred vision 0.8141522313838525 2.647021729107362 0.0081204135012198 1.0 0.039921732110723 4 P00846 1 +Heterogeneous 0.54280092381161 2.6441227207269384 0.0081902955336328 1.0 0.0401127269302412 39 P49815,P00846,Q9BQE5,Q9NR77,P06753,P40939,P53634,Q9Y619,P61916,P05067,O75844 11 +Scanning speech 0.6707478491065576 2.639538899426786 0.0083018895176414 1.0 0.0404661856466931 2 O14773 1 +Temporal cortical atrophy 0.7391592188016924 2.6311983964862846 0.0085084350166126 1.0 0.0410792268681817 3 O43924,P55072 2 +Abnormal pericardium morphology 0.7462441739181501 2.6111338384776768 0.0090242568720944 1.0 0.0428659613551033 12 Q9NZ08,Q14108,P14174 3 +Hyperphosphatemia 0.6651224354732024 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 Q15813 1 +Bacterial endocarditis 0.6651224354732024 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 P04062 1 +Abnormality of the vestibulocochlear nerve 0.6651224354732023 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 Q15046 1 +Abnormal thyroid stimulating hormone level 0.6651224354732023 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 O14654 1 +Absent hypoplastic paranasal sinuses 0.6651224354732024 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 A6NHR9 1 +Neoplasm of the inner ear 0.6651224354732023 2.608855880864716 0.0090845493804785 1.0 0.0428659613551033 2 Q15046 1 +Cutaneous melanoma 0.6634679020516273 2.599809270723739 0.0093275586721044 1.0 0.0438769126847091 2 P11802 1 +Abnormal ossification involving the femoral head and neck 0.8028116773331504 2.5951462522749797 0.0094550676461047 1.0 0.0443400047297349 4 Q14739 1 +Splanchnic vein thrombosis 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.0444012156892565 2 Q9NWH9 1 +Vitreoretinopathy 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.0444012156892565 2 O15484 1 +Portal vein thrombosis 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.0444012156892565 2 Q9NWH9 1 +Epigastric pain 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.0444012156892565 2 Q9NWH9 1 +Retinal neovascularization 0.6621442753143671 2.5925647054581904 0.0095263259355145 1.0 0.0444012156892565 2 O15484 1 +Abdominal wall muscle weakness 0.6614824619457371 2.588939995197846 0.0096271868556865 1.0 0.0447801160960134 2 A6NHR9 1 +Mixed hypo and hyperpigmentation of the skin 0.8007697458626979 2.5857708927996748 0.0097161489707002 1.0 0.0451480343542083 4 Q9H488 1 +Pes cavus 0.4046361702910692 2.5827506778695044 0.0098016127095537 1.0 0.0454528686642627 99 O95831,Q9Y4W2,Q9BZH6,P50542,Q7LGA3,Q9UGU0,Q9NR77,O75530,Q99720,P06753,P40939,Q08J23,O15269,Q14739,P49773,O60828,Q10713,Q9Y6X9 18 +Ectrodactyly 0.6980218492572128 2.5788217658362487 0.0099137923318142 1.0 0.045741358369671 16 P48449,Q9NR77,Q99720,P49773,Q6DKJ4,Q9Y6X9 6 +Abnormal granulocytopoietic cell morphology 0.7981980062634046 2.57394777486398 0.0100545448794444 1.0 0.0463318699436573 4 Q07020 1 +Unilateral ptosis 0.7270822099716675 2.57092285925982 0.0101427916878173 1.0 0.04665684176396 3 Q9UHX1 1 +Abnormal cochlea morphology 0.7263610657285786 2.5673095837142204 0.0102491062861558 1.0 0.0470985536864811 3 O60220 1 +Ulnar deviation of the hand 0.7261009509807594 2.5660058944647193 0.0102877079923238 1.0 0.0471812018846353 3 Q14739 1 +Hyperorality 0.6561879549966969 2.5598839616069933 0.0104707118336184 1.0 0.0478714818527987 2 P55072 1 +Short stepped shuffling gait 0.6561879549966971 2.5598839616069933 0.0104707118336184 1.0 0.0478714818527987 2 P04062 1 +Ulnar deviation of the wrist 0.7947859452724346 2.5582352591813216 0.0105204891845427 1.0 0.0479127154205493 4 P16278 1 +Abnormal natural killer cell physiology 0.7240210578901122 2.555574063651128 0.0106012797589951 1.0 0.0480422493007813 3 Q9Y6K9 1 +Abnormal csf protein level 0.769933533587352 2.555569657464953 0.0106014139816013 1.0 0.0480422493007813 11 P00403,Q9NR77,O15382,P07602,O43681 5 +Smooth muscle antibody positivity 0.6542025148908069 2.5489611620810755 0.0108044331905303 1.0 0.0487691229911809 2 P49327 1 +Sensory axonal neuropathy 0.681074397950732 2.547356808538931 0.0108542388342951 1.0 0.0489456661522846 17 P49773,O95831,Q8IV08,Q9Y6X9 4 +Abnormality of circulating leptin level 0.7921252030786319 2.545961823664359 0.0108977105758505 1.0 0.0490933280567597 4 O75844 1 +Reduced brain n acetyl aspartate level by mrs 0.7218537303725501 2.544689592257919 0.010937491805639 1.0 0.0491274779140432 3 P07602 1 +Abnormal brain choline level by mrs 0.7218537303725501 2.544689592257919 0.010937491805639 1.0 0.0491274779140432 3 P07602 1 +Abnormal brain n acetyl aspartate level by mrs 0.7218537303725501 2.544689592257919 0.010937491805639 1.0 0.0491274779140432 3 P07602 1 +Dilated third ventricle 0.7183314704849216 2.526969802906683 0.0115051394604046 1.0 0.0512247308465682 3 P26358 1 +Asymmetry of the ears 0.7176431645150506 2.5235026207396527 0.0116192194499733 1.0 0.0516322013810951 3 Q9UHX1,P52788 2 +Hydranencephaly 0.6492389146260815 2.521590092896766 0.0116825755078406 1.0 0.0518131280032818 2 Q53EZ4 1 +Arthritis 0.525035386370484 2.520569057532709 0.011716524535797 1.0 0.0519133909006226 40 Q05655,P49327,P10321,P14174,O00170,Q14108,Q14807,Q92766,Q9NZ08,Q14739,Q9H488,O75844 12 +Amyloidosis 0.7859889980792175 2.517587422438521 0.0118161641836613 1.0 0.0523042393313521 4 P05067,P09884 2 +Proportionate short stature 0.5451035428171047 2.5062910504919933 0.0122005144935406 1.0 0.0539013077576598 32 Q13555,Q15392,P40939,P10619,P16278,Q7RTS9,Q14739 7 +Absent frontal sinuses 0.6455989410986165 2.5014596976858083 0.0123682518865031 1.0 0.0544845898792347 2 P21333 1 +Abnormality of frontal sinus 0.6455989410986165 2.5014596976858083 0.0123682518865031 1.0 0.0544845898792347 2 P21333 1 +Hamartomatous polyposis 0.6452680344143015 2.4996272130248514 0.012432405387158 1.0 0.0546619783448822 2 P21912 1 +Antiphospholipid antibody positivity 0.7126480251171772 2.498297096067898 0.0124791559017958 1.0 0.0548148719409976 3 Q05655 1 +Abnormality of peripheral nerves 0.5111204770066881 2.4923698216412675 0.0126893836639847 1.0 0.0556848600479944 43 O95831,Q9NR77,Q99720,P07602,O43681,O15269,P31930,Q9Y619,Q9Y6X9 9 +Fibular aplasia 0.7110228401191632 2.490079831257157 0.012771440498779 1.0 0.0557185005899475 3 P21333,Q9Y5S9 2 +Laryngeal stenosis 0.7110228401191601 2.4900798312571446 0.0127714404987795 1.0 0.0557185005899475 3 Q14807,Q96HY6 2 +Broad face 0.7110228401191413 2.4900798312570456 0.012771440498783 1.0 0.0557185005899475 3 P21333,Q6PJG6 2 +Segmental peripheral demyelination remyelination 0.843084652191932 2.486620680908415 0.0128962821334388 1.0 0.0561620202899615 5 Q9NR77 1 +Abnormality of the distal phalanges of the toes 0.8427178417104593 2.485031916090924 0.0129539820165609 1.0 0.0561994082367767 5 O75844 1 +Elevated pulmonary artery pressure 0.6126570355996772 2.4819276545593163 0.013067380263749 1.0 0.0565306233149145 22 P21333,P00403,Q9Y6K9,P20674,Q69YQ0,P11047,O75531,Q8IZA0,Q14108,P51970,O75844 11 +Abnormal b cell subset distribution 0.7083679590339884 2.4766386997531016 0.0132626082500433 1.0 0.057266941472121 3 Q05655 1 +Fasting hyperinsulinemia 0.7756730509222145 2.469666770469871 0.0135238964592381 1.0 0.0582851921788445 4 P40939,P00367 2 +Oromandibular dystonia 0.8380878972260979 2.4649525206024774 0.0137031408170802 1.0 0.058844497319808 5 O60220,Q15043,Q99720 3 +Distal lower limb muscle weakness 0.6668820100051324 2.463426446295032 0.0137616128248059 1.0 0.0589213301208014 17 P06753,P00846,Q9NR77,P49773 4 +Abnormality of the intrahepatic bile duct 0.7718450705210738 2.451814731361865 0.0142137823916272 1.0 0.0607436806783175 4 P50542 1 +Abnormality of the tarsal bones 0.5749300185618393 2.4481764262585903 0.0143581330489266 1.0 0.0612462022040421 26 P98175,Q9UPW6,Q15125,P40939,Q5SRE5,Q7RTS9,Q14739,O75844 8 +Abnormal metatarsal morphology 0.5989585735245482 2.4471614751282105 0.0143986314688209 1.0 0.061361765579882 23 O96028,P50542,Q9H7D7,Q14807,Q15392,P08236,Q08J23,Q7RTS9,P49773,Q9H9E3,Q9UBM7 11 +Right ventricular hypertrophy 0.7680873663512771 2.434253556275687 0.0149225377093002 1.0 0.0634173213514089 4 Q9H267,P11047 2 +Long clavicles 0.6994372724263287 2.431264714917242 0.015046217149405 1.0 0.0635300146612793 3 O75369,Q14739 2 +Posterior pituitary dysgenesis 0.7661201090849807 2.4250452387458963 0.0153064792514254 1.0 0.064391319424425 4 Q9BZH6 1 +Decerebrate rigidity 0.8272144213233154 2.417608095311445 0.0156228929554151 1.0 0.0656018174834269 5 P07602,O43681,P16278 3 +Hypergonadotropic hypogonadism 0.6995535186246142 2.412489356026003 0.0158440000563633 1.0 0.0664084141556547 13 P48449 1 +Disproportionate short limb short stature 0.5935727265197468 2.410183299743922 0.0159445075590587 1.0 0.0667075055738682 23 Q7LGA3,O75718,Q15392,Q15125,O00116,Q7RTS9,Q14739,Q9UBM7,Q6DKJ4,Q9BV10 10 +Increased cerebral lipofuscin 0.82500152156076 2.4079405773284908 0.0160427919980228 1.0 0.066935149475798 5 P07602,Q9NZJ7,P50897 3 +Abnormal circulating amino acid concentration 0.4519089850737431 2.405062704226025 0.0161696910648956 1.0 0.0673418343985689 54 P00846,Q9BUB7,P11182,Q99797,P05067,P35270,O15382,P09622,O95298,P55263,P41440,Q9Y619,Q6PGP7,P32929 14 +Abnormal c reactive protein level 0.7613879707759843 2.4028540312439337 0.0162676794405052 1.0 0.0676883352719931 4 P14174 1 +Aplasia hypoplasia involving bones of the lower limbs 0.3974804475536146 2.4008675726652404 0.0163562545156481 1.0 0.0677550231159745 89 O95831,Q9Y4W2,Q69YQ0,O96028,Q13555,P50542,Q9UPW6,P00813,Q7LGA3,Q08J23,O00116,Q7RTS9,O15111,Q9Y619,P49773,Q9UGU0,Q9BV10 17 +Calcinosis 0.8233765768347323 2.400834707340684 0.0163577235182765 1.0 0.0677550231159745 5 O75844 1 +Synostosis of metacarpals metatarsals 0.6933846654758676 2.4003731417012153 0.0163783666645134 1.0 0.0677791900754773 3 O60828 1 +Impaired horizontal smooth pursuit 0.6932751728680977 2.3998132641719807 0.016403437445907 1.0 0.067821619864423 3 P41440 1 +Decreased specific antibody response to protein vaccine 0.6900819621908574 2.3834688301732614 0.0171503367860976 1.0 0.0705274855974564 3 Q9BV10 1 +Hypochromia 0.6234281932495106 2.377777934596455 0.0174173115163955 1.0 0.071561072540882 2 P11172 1 +Aplasia hypoplasia of the retina 0.6888100156542417 2.3769495832275744 0.0174564739116713 1.0 0.0715934418402508 3 Q9Y6K9 1 +Bulbar signs 0.6913345219814319 2.3673889045765972 0.017914097415316 1.0 0.072882510106579 13 P00846,Q99720,P06753,P07602,O43681,Q15043 6 +Hypopigmentation of the fundus 0.7533112582781384 2.3648444727850957 0.0180376440180574 1.0 0.0733199792812156 4 P49815,Q6P2Q9,Q9Y619 3 +Fibroadenoma of the breast 0.686095335131411 2.363018972224306 0.0181267416002652 1.0 0.0736167669071998 3 Q05655 1 +Cutaneous finger syndactyly 0.6859960592766454 2.3625090971486458 0.0181516959339331 1.0 0.0736527591219965 3 Q9Y619 1 +Proximal symphalangism 0.6855127957607328 2.3600266474904283 0.0182736223793957 1.0 0.073885485539306 3 O60828 1 +Symphalangism affecting the phalanges of the hand 0.6855127957607328 2.3600266474904283 0.0182736223793957 1.0 0.073885485539306 3 O60828 1 +Pilomatrixoma 0.6174718729318404 2.344236022851418 0.019066101764384 1.0 0.0764146653026145 2 P35222 1 +Germinoma 0.6174718729318404 2.344236022851418 0.019066101764384 1.0 0.0764146653026145 2 P35222 1 +Abnormality of skin pigmentation 0.3564679795852454 2.342603901612817 0.0191497011697585 1.0 0.0766155439283085 126 P00403,P52788,Q15125,Q9NYB0,Q9NZJ7,Q6PGP7,P49815,P21333,Q9Y6K9,O00170,Q9Y4I1,Q7LGA3,Q8IZA0,O75530,P07602,P50336,Q08J23,P36551,Q9H4L7,P33991,Q8ND04,O14617,P09884,Q9H488,O75844,P49327,Q01968,Q15022,O75531,Q06136,Q13423,Q92766,P53634,Q14739,Q9UGU0 35 +Abnormality of upper limb joint 0.3677242150209133 2.3384549195311304 0.0193636616229988 1.0 0.0774039120073936 118 O96028,Q9NR77,Q7RTS9,P49773,O95831,Q9Y6K9,Q9BUB7,Q7LGA3,Q15392,O75530,P06753,Q9BV10,P42892,O95425,O60828,Q9Y6X9,O75844,P50542,P16278,Q9Y619,Q6DKJ4 21 +Toxemia of pregnancy 0.808853824674999 2.3370651204731345 0.0194357982922823 1.0 0.0776244753785134 5 O43772 1 +Pericarditis 0.8085017620040331 2.3355133643959545 0.0195166185706652 1.0 0.0778793053164208 5 P14174 1 +Gastrointestinal stroma tumor 0.6795762992386596 2.3294727553426644 0.0198340346873155 1.0 0.079008160804043 3 Q05655,P31040 2 +Noncompaction cardiomyopathy 0.6795762992386584 2.329472755342656 0.019834034687316 1.0 0.079008160804043 3 Q15233,P31040 2 +Flexion contracture of digit 0.4166804751939583 2.318909887632569 0.0203999228948426 1.0 0.0811103529491177 74 Q9Y6X9,Q9Y6K9,Q9BZH6,P50542,Q9BUB7,O75530,O95425,P42892,P06753,Q6DKJ4,Q5SRE5,Q7RTS9,O60828,Q9Y619,P49773,O75844,Q9BV10 17 +Hypoplastic aortic arch 0.6765885010902157 2.3140538948584344 0.0206647660029086 1.0 0.0818188875391981 3 Q9UHX1 1 +Lambdoidal craniosynostosis 0.6115155526141702 2.3105609585946265 0.0208571178125129 1.0 0.0824378482105975 2 P61978 1 +Muscle stiffness 0.6183776379348705 2.306382368044582 0.021089276321401 1.0 0.0831027289214117 19 P00846,Q9Y4I1,Q15392,P06753,P07602,P49773 6 +Foot dorsiflexor weakness 0.5377857203672474 2.30637842339329 0.0210894965418795 1.0 0.0831027289214117 30 Q9NR77,Q99720,P06753,Q14739,P49773,Q9Y6X9 6 +Abnormal left atrium morphology 0.6088682991396501 2.2955515345062083 0.0217015366005213 1.0 0.0846064165422368 2 Q14315 1 +Orthopnea 0.6088682991396501 2.2955515345062083 0.0217015366005213 1.0 0.0846064165422368 2 Q14315 1 +Pulmonary venous hypertension 0.6088682991396501 2.2955515345062083 0.0217015366005213 1.0 0.0846064165422368 2 Q14315 1 +Interstitial cardiac fibrosis 0.6088682991396501 2.2955515345062083 0.0217015366005213 1.0 0.0846064165422368 2 Q14315 1 +Left atrial enlargement 0.6088682991396501 2.2955515345062083 0.0217015366005213 1.0 0.0846064165422368 2 Q14315 1 +Parietal bossing 0.60688285903376 2.284277219145056 0.0223552438607685 1.0 0.0867853699327717 2 Q06124 1 +Neuronal loss in central nervous system 0.6846057439576568 2.2817324985107086 0.0225051381554723 1.0 0.0872932350318619 12 P26358,P07602,Q6PJG6,Q9NZJ7,O15118 5 +Limited wrist movement 0.7952408287682987 2.2768629917979184 0.0227944084732651 1.0 0.0880422004912529 5 P21333,O75844,P11047 3 +Hypometric saccades 0.6693073691475186 2.276363086940501 0.0228242870886665 1.0 0.0880832731912537 3 O15020 1 +Increased bone mineral density 0.5566274127535943 2.271496600549873 0.0231169325278708 1.0 0.0891255341088419 25 Q14108,Q15392,Q15125,Q14739,Q9UIG0,Q13126,Q15043 7 +Thoracic scoliosis 0.6812053286582291 2.263207399227507 0.0236229073239522 1.0 0.0909352790763072 12 P06753,P49773,O75844,P50542 4 +Disproportionate short trunk short stature 0.7910975948956953 2.2584579990445492 0.0239171202891483 1.0 0.0916051466682388 5 Q9UHX1,P16278,Q7RTS9 3 +Onychomycosis 0.6022501654533499 2.257913032291844 0.0239510819604849 1.0 0.0916051466682388 2 Q9Y5L0 1 +Tapered distal phalanges of finger 0.6657013243155434 2.257635673245923 0.0239683826958627 1.0 0.0916051466682388 3 P53634 1 +Postural tremor 0.632204960436279 2.2551005448204813 0.0241270184622373 1.0 0.0920376545105412 17 P00846,Q14108,Q9NR77 3 +Abnormal circulating branched chain amino acid concentration 0.8518233198867524 2.2550454629590835 0.0241304752922546 1.0 0.0920376545105412 6 P09622,P11182 2 +Acquired abnormal hair pattern 0.7882697686126621 2.2458743640419208 0.0247120563619018 1.0 0.0937928273154232 5 Q9Y6K9,O75844 2 +Abnormal circulating ceruloplasmin concentration 0.6624363811239886 2.2406450731092393 0.025049074627705 1.0 0.094908621333614 3 Q8N511 1 +Sensorimotor neuropathy 0.5206027993779334 2.238194009720352 0.0252084061307851 1.0 0.0953544420335566 31 P00846,O95831,P00403,Q5KU26,Q9NR77,P07602,P40939,P41440 8 +Abnormal thyroid hormone level 0.5976174718729396 2.231468506475968 0.0256501113934495 1.0 0.096072471233894 2 O14654 1 +Equinovarus deformity 0.7842017138014418 2.227740642388565 0.0258978151211248 1.0 0.0969209319782408 5 Q9NR77 1 +Contractures of the large joints 0.6595100836739203 2.2253888243475632 0.0260551471248511 1.0 0.0974300722144147 3 P50542 1 +Abnormal circulating lipid concentration 0.3814892400267023 2.22305781095425 0.0262119019940285 1.0 0.0976969669598279 82 Q96NT0,Q15125,P22830,Q9NZJ7,P35250,Q9Y4I1,Q15392,O43772,P07602,P09622,Q15800,Q9BV10,Q8N511,P40939,P35573,P31751,P61916,O75844,Q01968,P49257,P28340,P50542,Q13045,Q9H9E3,Q14739,Q9UIG0 26 +Upper airway obstruction 0.7226112745120886 2.218826025657262 0.0264985627032263 1.0 0.0986048142216805 4 O75844 1 +Mitochondrial inheritance 0.7224282228562628 2.217948070475136 0.026558373355257 1.0 0.0986669438693274 4 P00846 1 +Abnormality of the extraocular muscles 0.5949702183984196 2.21632133447306 0.0266695029197334 1.0 0.0989192178797569 2 P43243 1 +Limitation of knee mobility 0.7211920529801237 2.2120168746484956 0.0269654989908785 1.0 0.0999361043572882 4 P21333,Q7RTS9,P55072 3 +Diastasis recti 0.7210084777042515 2.211135737173191 0.0270264388555685 1.0 0.1000809147588489 4 Q69YQ0 1 +Abnormal heart rate variability 0.7202010877347649 2.2072593407686507 0.0272959461437185 1.0 0.1009156264134085 4 P07602 1 +Abnormal corneal epithelium morphology 0.6240551365533664 2.205472456808127 0.027420958489664 1.0 0.1012959862850625 17 Q9NZ08,O75844,Q14739 3 +Aplasia hypoplasia of the sternum 0.7195849145704805 2.20429987571198 0.0275032616929165 1.0 0.1014362842614656 4 Q9Y619 1 +Male hypogonadism 0.7589487398155063 2.201249915064086 0.0277183364097179 1.0 0.1019010648572524 9 P09884,Q9BZH6 2 +Broad phalanx of the toes 0.7778816494027305 2.1994956074570946 0.0278427011283572 1.0 0.1022761180292867 5 Q7LGA3,Q6DKJ4 2 +Nephropathy 0.5873428299178186 2.180194110943409 0.0292430759630524 1.0 0.1065649352570787 20 P00403,P06280,P43034,Q14108,Q9NPF4,P36551,P35579,Q10713 8 +Abnormality of metacarpophalangeal joint 0.7139174429675117 2.1770333973388403 0.0294780756935308 1.0 0.1073358412484414 4 P21333,O60828 2 +Atrophy degeneration involving the caudate nucleus 0.7711613366243281 2.1693649534610913 0.0300549875138793 1.0 0.1091187336711324 5 P00846 1 +Abnormal pupillary light reflex 0.7703294240614295 2.1656281312016934 0.0303396149360644 1.0 0.1098610898436446 5 P07602,Q9NR77 2 +Slow pupillary light response 0.7703294240614295 2.1656281312016934 0.0303396149360644 1.0 0.1098610898436446 5 P07602,Q9NR77 2 +Tracheal stenosis 0.7112582781456878 2.16421163627635 0.0304481106469092 1.0 0.1101157886297262 4 Q9UBM7,Q15125,Q96HY6 3 +Small epiphyses 0.7112313743130326 2.164081820906565 0.0304580704402956 1.0 0.1101157886297262 4 O95831 1 +Impaired vibration sensation in the lower limbs 0.6458448233592619 2.163089665608451 0.0305342838029072 1.0 0.1103041965003207 14 P49773,Q9NR77 2 +Bell shaped thorax 0.6471041766166772 2.160418160242433 0.0307403128470107 1.0 0.1109608926662209 3 Q96HY6 1 +Hypochromic microcytic anemia 0.6458126448195944 2.1536272010484545 0.0312694193392077 1.0 0.1119637801715919 3 Q15046,O75027 2 +Abnormality of the ribs 0.4193948629374537 2.153447480990095 0.031283527416932 1.0 0.1119637801715919 61 P15586,Q9Y6K9,O95831,O75531,P00813,P16278,Q6DKJ4,Q7RTS9,Q14739,Q9Y619,O75844,Q9BV10 12 +Aplasia hypoplasia of the breasts 0.748833636968314 2.1532202104426927 0.0313013760419635 1.0 0.1119637801715919 9 Q9Y6K9,Q9BZH6 2 +Dementia 0.4234043441657579 2.1530888380675113 0.0313116973169407 1.0 0.1119637801715919 55 P00846,P00403,P61916,P26358,Q14108,P07602,O43681,O60220,Q9NZJ7,P05067,O15118 11 +Hypoplasia of the musculature 0.7673281747115293 2.1521343317763804 0.0313867758521424 1.0 0.1120734836924861 5 P06753,Q9Y487,Q9NR77 3 +Adenomatous colonic polyposis 0.6454816285997854 2.151885875660496 0.0314063439611052 1.0 0.1120734836924861 3 Q07864,P28340 2 +Wide cranial sutures 0.801881466102018 2.151765408128044 0.0314158356079221 1.0 0.1120734836924861 7 P98175,O75844,O75531 3 +Metaphyseal striations 0.8269947553134966 2.1511628775703553 0.0314633459827917 1.0 0.1121555565134251 6 P00813,Q9H7D7,Q13126 3 +Progressive gait ataxia 0.6906784520067454 2.1494882250703142 0.0315957184992798 1.0 0.1125397693161121 11 P00846,O15020,P15289,P07602,O43681,Q9NZJ7 6 +Broad foot 0.6904848225484866 2.1484739838946956 0.0316761209703464 1.0 0.1127384181036358 11 O95831,O00170,O75530,Q8IWS0,Q7RTS9 5 +Abnormal motor nerve conduction velocity 0.6027974897433 2.1383050856628207 0.0324919900757141 1.0 0.1147498754448638 18 Q9NR77,P31930,Q99720 3 +Abnormality of neutrophil morphology 0.7639133296767724 2.1367569263038084 0.0326177672139809 1.0 0.1151052587034623 5 P41440,Q14739 2 +Anal stenosis 0.705087145247896 2.13438649234459 0.032811156375696 1.0 0.1156503636421439 4 Q08J23 1 +Ectopia pupillae 0.7050578157263152 2.134244510616784 0.0328227708916637 1.0 0.1156503636421439 4 P61586 1 +Abnormal circulating proteinogenic amino acid concentration 0.4956617973426351 2.133041951628466 0.0329212849436797 1.0 0.115819155409087 34 P11182,P35270,O15382,P09622,O95298,P55263,P41440,Q6PGP7 8 +Atlantoaxial abnormality 0.704181292127581 2.130000323793921 0.0331715866350972 1.0 0.1165206078502225 4 Q7RTS9 1 +Glomerular deposits 0.579748510919929 2.1287189894818463 0.0332775167793872 1.0 0.1166746238870595 2 P52565 1 +Horizontal nystagmus 0.5531408336862226 2.1280501777772143 0.0333329234950521 1.0 0.1166746238870595 23 P00846,O95831,P50542,P07602,Q9H061 5 +Hand polydactyly 0.5242108873163958 2.1257489356887573 0.0335241699348829 1.0 0.1171298670167627 28 O96028,P98175,O43924,Q15125,Q13045,Q92766,Q15067,Q9UBM7,Q14739,Q9UHX1,Q10713 11 +Extramedullary hematopoiesis 0.703165667950296 2.1250801584877093 0.0335799248843604 1.0 0.1171980547836498 4 Q14739 1 +Long hallux 0.639413815321853 2.119906704378573 0.0340139138996855 1.0 0.1184792115059823 3 P52788 1 +Abnormality of the musculature of the lower limbs 0.5438869683005938 2.118170308649266 0.0341606467830297 1.0 0.1187662825739349 24 P49773,Q9NR77 2 +Biliary cirrhosis 0.793946941578826 2.116991110241403 0.0342606022733356 1.0 0.1189763100190114 7 P14174,Q14739 2 +Neck muscle weakness 0.6286933389771953 2.116159715842096 0.0343312260804118 1.0 0.1190895478461446 15 P06753,P07602,Q9Y6X9,Q99720 4 +Abnormal tendon morphology 0.3030681555486386 2.115994813682363 0.0343452486687592 1.0 0.1190895478461446 214 P15586,Q9NR77,Q5SRE5,Q7RTS9,P49773,Q15043,O95831,Q9Y6K9,Q9BUB7,Q7LGA3,Q15392,O75530,P06753,Q08J23,P41440,Q9BV10,P48449,Q9BZH6,Q8IYI6,P42892,O95425,Q99720,P50897,Q96KP1,O60828,O75844,Q9Y6X9,Q86XL3,Q86XI2,O75531,P50542,Q6PJG6,Q9Y619 33 +Abnormal intraocular pressure 0.7587098683901102 2.1132761099822246 0.0345771422611993 1.0 0.1195314049316536 5 P04439,Q15043 2 +Neurofibrillary tangles 0.8148523645867956 2.0999307002901166 0.0357349376701128 1.0 0.1231617543042969 6 P05067,O15118 2 +Abnormal morphology of myocardial trabeculae 0.6972436689129389 2.0963390611286465 0.0360521240199047 1.0 0.1241614534530504 4 Q15233,Q99797 2 +Bilateral camptodactyly 0.5737921906022587 2.0942065604747273 0.0362415836181457 1.0 0.1243461231036381 2 Q9BYW2 1 +Sacrococcygeal teratoma 0.5737921906022587 2.0942065604747273 0.0362415836181457 1.0 0.1243461231036381 2 Q9BYW2 1 +Neoplasm of the middle ear 0.5737921906022587 2.0942065604747273 0.0362415836181457 1.0 0.1243461231036381 2 Q9BYW2 1 +Abnormal pupillary function 0.7881441168141594 2.091478405542564 0.0364852002178679 1.0 0.1250882107844056 7 P07602,Q9NR77,Q6XZF7 3 +Abnormal circulating porphyrin concentration 0.6961237503738986 2.0908938080410433 0.0365375842915418 1.0 0.1251740443880142 4 P36551,P22830 2 +Abnormality of fundus pigmentation 0.7535607817158074 2.0899825514825916 0.0366193671242713 1.0 0.1253603914194391 5 P49815,Q6P2Q9,O15484,Q9Y619 4 +Anotia 0.6954965712804884 2.0878429633691664 0.0368120025957185 1.0 0.125925662093127 4 Q9Y619 1 +Abnormal vascular physiology 0.4446096396730626 2.0848029496846183 0.0370871908693544 1.0 0.1265832010507346 49 P21333,P00403,Q9Y6K9,P20674,P49327,P11047,P06280,O75531,Q14108,Q8IZA0,Q69YQ0,Q9UIG0,Q9NZ08,Q14739,P51970,P35250,P05067,O75844 18 +Motor axonal neuropathy 0.592784716506305 2.0750950974007356 0.0379777220251373 1.0 0.1293333584144745 18 Q13057,O95831,O15269,P49773,Q9Y6X9 5 +Clonus 0.5083615993935054 2.0743058242431056 0.0380509172511458 1.0 0.1294862812330814 30 Q99720,P07602,O60220,Q6PJG6,Q9Y619,Q15043 6 +Abnormality of the alveolar ridges 0.8086640124363714 2.0737131840290473 0.03810595605589 1.0 0.1295772369003037 6 P53634,Q15392,P98175,O43924 4 +Barrel shaped chest 0.6922990407076828 2.072273517851152 0.0382399406414739 1.0 0.1299363090690618 4 Q14739 1 +Abnormal joint morphology 0.2964894441125451 2.0575766065364616 0.0396307941905564 1.0 0.1343630703779089 265 Q03164,O96028,P10321,P43034,Q14108,Q9NR77,Q15125,Q9NPF4,O60220,Q92947,O15269,Q7RTS9,P49773,Q9Y584,Q9NZJ7,P35250,Q15043,O95831,P21333,Q9Y6K9,P14174,O00170,Q9UPW6,Q9BUB7,Q7LGA3,Q8IZA0,Q15392,O75530,Q14807,P06753,P07602,Q9BTW9,Q9BV10,Q9H4L7,Q05655,Q9Y487,O75718,P42892,O95425,P08236,Q9NZ08,O15111,O60828,Q8NCH0,Q9UHX1,Q9H488,O75844,Q9Y6X9,Q86XL3,Q01968,P49327,P49257,P50542,Q92766,Q8IWS0,P16278,Q14739,Q9Y619,Q9UIG0,Q9UBM7,Q6DKJ4 61 +Thin skin 0.5270136856797761 2.053651256970534 0.0400094573648024 1.0 0.1354462177209325 25 O00170,Q9UPW6,O15111,Q9Y619,Q13126,O75844,Q9H4L7 7 +Subcortical band heterotopia 0.6259496261179688 2.048548317084488 0.0405063028385086 1.0 0.1366128240320318 3 P43034 1 +Subcortical heterotopia 0.6259496261179688 2.048548317084488 0.0405063028385086 1.0 0.1366128240320318 3 P43034 1 +Abnormal thoracic spine morphology 0.5141842418317432 2.04827412089975 0.0405331472657852 1.0 0.1366128240320318 28 O95831,P50542,Q14807,P06753,Q7RTS9,P49773,Q9UHX1,O75844 8 +Increased circulating igg level 0.6871326888601281 2.0470632341023487 0.0406518762671406 1.0 0.1367017266515091 4 Q05655,P49327 2 +Clonic seizure 0.743901172336748 2.046129301764854 0.0407436507792386 1.0 0.1367017266515091 5 P07602 1 +Ureteropelvic junction obstruction 0.6252875936783797 2.045025587572028 0.0408523355388066 1.0 0.1367017266515091 3 Q9UBM7 1 +Impaired tactile sensation 0.7775851329920651 2.0448808223224257 0.0408666090478835 1.0 0.1367017266515091 7 Q9NR77,Q9Y6X9 2 +Abnormal auditory evoked potentials 0.7258998719101551 2.043424784596573 0.0410104060683691 1.0 0.1369107429430529 9 P07602,O60220,Q15125 3 +Loss of speech 0.576406441732969 2.03657960894625 0.0416921879172464 1.0 0.1390853819950708 19 P50897,P07602,O43681,P61916,O15118 5 +Conjugated hyperbilirubinemia 0.6236345580933393 2.036223940957864 0.0417278732675252 1.0 0.1391030414752098 3 Q9H267,Q9Y5L0 2 +Pancreatic islet cell hyperplasia 0.6231546008136621 2.033666866781346 0.0419851949767169 1.0 0.1397572635697697 3 Q14739 1 +Abnormality of somatosensory evoked potentials 0.6841094866153757 2.032279968215652 0.0421253212160452 1.0 0.1401213405385851 4 O60220 1 +Cupped ribs 0.797431221383102 2.0259415091142707 0.0427707788948803 1.0 0.1417536965980212 6 O95831 1 +Abnormality of femur morphology 0.4043401777243723 2.024540380254413 0.0429145815599398 1.0 0.1421273804629846 65 Q7RTS9,Q9NZJ7,O95831,P21333,Q7LGA3,Q14807,O75530,P07602,Q9BV10,Q9Y487,O75718,Q9UHX1,O75844,P50542,P16278,O00116,Q14739,Q9Y619,Q9H9E3 19 +Scarring alopecia of scalp 0.6824090153467187 2.0239547852272715 0.0429748041796362 1.0 0.1421463033898154 4 P61586 1 +Abnormal foramen magnum morphology 0.6213189800871413 2.023880890979477 0.0429824085408574 1.0 0.1421463033898154 3 P21333 1 +Hypoglycemic seizures 0.7724137854348836 2.0219780650130685 0.0431786179863775 1.0 0.1425891302479438 7 P00367,Q13423,P40939,P53985,P31751 5 +Ventricular preexcitation 0.7948293187585143 2.0148425549231583 0.0439211485980015 1.0 0.1440571293890773 6 P49815,P00846,P00403 3 +Chorioretinal hypopigmentation 0.6194964530597586 2.014154832926043 0.0439932801018922 1.0 0.1440571293890773 3 P49815 1 +Scarring 0.5003043054765351 2.0098955931690856 0.0444422402761361 1.0 0.1446936349149158 30 Q6P2Q9,P21333,Q9Y6K9,P04439,Q01968,Q86XI2,P61586,Q15125,P36551,P53634,P09884,Q8NCH0,Q92542 13 +Hypopigmentation of the skin 0.4411369416210133 2.009567333779308 0.044477001499755 1.0 0.1446936349149158 48 P49815,P49327,Q9Y6K9,Q01968,Q9Y4I1,Q8IZA0,P52788,Q15125,O14617,Q92766,P07602,P53634,Q9NZJ7,Q9H488,Q6PGP7 15 +Short thorax 0.6786616572480791 2.0055831590507163 0.0449007401786856 1.0 0.1452372351928226 4 Q7RTS9 1 +Synostosis of carpal bones 0.6177759434410225 2.0049641859955596 0.0449668759114225 1.0 0.1453484400046476 3 Q6DKJ4 1 +Emg neuropathic changes 0.5095200737150735 2.002435603532946 0.0452379025056162 1.0 0.1461212983544145 27 P49773,O43681,Q9NR77,P07602 4 +Limited hip movement 0.625429813765473 1.997754703900397 0.0457432602959924 1.0 0.1475453857468338 13 Q7LGA3,O75844 2 +Abnormality of the metaphysis 0.4353883804410331 1.9912891571709337 0.0464491068188637 1.0 0.1487890870780141 49 O95831,P21333,Q01968,Q9HC07,Q15022,P50542,P00813,Q9H7D7,Q14807,O75530,P16278,Q07864,Q7RTS9,Q14739,Q9H9E3,Q13126 16 +Tritanomaly 0.6151875566418734 1.9911210669907724 0.0464675788983242 1.0 0.1487890870780141 3 Q9H6K4 1 +Anomalous trichromacy 0.6151875566418734 1.9911210669907724 0.0464675788983242 1.0 0.1487890870780141 3 Q9H6K4 1 +Babinski sign 0.3657399794981067 1.989596080010204 0.046635448325907 1.0 0.1490575747120646 84 P00846,O95831,P26358,Q9NR77,Q99720,Q15067,P07602,O43681,O60220,Q6PJG6,P40939,P41440,Q9UHD1,Q15043,Q9Y6X9 15 +Abnormal caudate nucleus morphology 0.6599701968133087 1.9873248858152128 0.0468864056209623 1.0 0.1495608431567886 11 Q13057,P00846,O60220,Q9BU61 4 +Abnormal circulating metabolite concentration 0.2846242205541042 1.987283987590796 0.0468909350950386 1.0 0.1495608431567886 342 Q92621,Q9BWD1,Q96NT0,Q15125,Q99797,Q9NPF4,P35270,O95298,P22830,O75251,P49773,Q9Y584,Q9NZJ7,Q6PGP7,P35250,Q70HW3,Q15043,P00390,O95831,O00170,P14174,Q9Y4I1,Q9BUB7,Q15392,Q5JRX3,O43772,P06753,P07602,P09622,O15382,Q08J23,Q15800,P55263,P41440,P36551,Q96CU9,P05067,P09493,Q9BTW9,Q9BV10,P32929,Q9BUK6,Q8N511,Q9Y6M9,Q05655,Q86Y39,Q9Y487,P11182,O95425,P22695,P40939,P35573,P53985,P31751,P13473,Q9BU61,P61916,O75844,P00846,Q01968,Q9HC07,P49257,P28340,P50542,P23378,Q8NFH4,Q13423,Q92766,Q13045,Q9H9E3,Q14739,Q9Y619,Q9UIG0 73 +Osteoarthritis 0.7383184727528702 1.9797868347561856 0.0477274863246315 1.0 0.1518059102903672 8 Q14108,O00170,O75844 3 +Abnormality of lysosomal metabolism 0.6730132828353987 1.977826382978208 0.0479482960901367 1.0 0.1522965657214127 4 P07602,Q9NZJ7 2 +Abnormal spermatogenesis 0.657239354926791 1.9727782360251975 0.0485208338197677 1.0 0.1534579561264112 11 Q9BZH6 1 +Enlarged ovaries 0.6117179741807358 1.9725343506621889 0.0485486389493172 1.0 0.1534579561264112 3 P21912,P10644 2 +Bronchomalacia 0.6117179741807313 1.9725343506621635 0.0485486389493201 1.0 0.1534579561264112 3 O75369,P63000 2 +Tarsal synostosis 0.6117179741807295 1.9725343506621535 0.0485486389493212 1.0 0.1534579561264112 3 P21333,O75369 2 +Synostosis involving bones of the lower limbs 0.6117179741807295 1.9725343506621535 0.0485486389493212 1.0 0.1534579561264112 3 P21333,O75369 2 +Abnormal platelet volume 0.7356149778935082 1.9672379206971704 0.0491557881745541 1.0 0.1544468961223612 8 P21333,O15143,P35579,Q14739,Q6PGP7 5 +Limb joint contracture 0.3586392306237894 1.9671562366483608 0.0491652015840682 1.0 0.1544468961223612 104 Q9Y6X9,Q9Y6K9,Q86XL3,P50542,Q9BUB7,Q7LGA3,Q9NR77,P42892,Q15392,Q99720,O75530,P06753,O95425,Q08J23,O60828,Q9Y619,P49773,O75844 18 +Progressive spastic quadriplegia 0.7085538258776718 1.9595688018556512 0.0500462108518036 1.0 0.1564884530664642 9 P43034,P15289,Q9Y263,P07602,O43681,Q9NZJ7 6 +Distal sensory impairment of all modalities 0.7817027121447016 1.9586592221136907 0.0501527089960447 1.0 0.1564884530664642 6 P49773 1 +Distal lower limb amyotrophy 0.6100112945548641 1.9553540123485684 0.0505413001235826 1.0 0.1571518550717646 14 P06753,P49773,Q9NR77 3 +Abnormal exteroceptive sensation 0.4192652044855902 1.954245155057353 0.0506722315053069 1.0 0.1573277334514841 52 O95831,Q9NR77,Q9NZ08,P07602,O15269,P49773,Q9NZJ7,P05067,Q9Y6X9 9 +Brain neoplasm 0.6082596487483064 1.9539730290695905 0.0507044069197264 1.0 0.1573277334514841 3 P28340 1 +Glomerulopathy 0.6810044614277508 1.9537320044476365 0.0507329192866303 1.0 0.1573277334514841 10 Q14108,Q9NZ08,P49327,Q01968 4 +Temperature instability 0.7562133207933133 1.9498893089034364 0.0511893136739423 1.0 0.1586279544249383 7 P35270,P07602,Q9NZJ7 3 +Short nail 0.7212972332107308 1.942733619388611 0.0520483519618593 1.0 0.1607458211399663 5 O75844 1 +U shaped upper lip vermilion 0.6059386235214792 1.9414963403635763 0.0521981028906868 1.0 0.1610178043033009 3 P28482 1 +Alkalosis 0.7210032477312771 1.9413818103718443 0.0522119829403402 1.0 0.1610178043033009 5 Q9Y619 1 +Broad palm 0.7296810413029015 1.939640791214676 0.0524233598593002 1.0 0.1612511546209793 8 O95831,Q7RTS9,Q14739 3 +Splenomegaly 0.3620820842237886 1.9381989791694112 0.0525989512570128 1.0 0.1616826057107776 84 P15586,Q14108,Q96NT0,Q9NZJ7,Q6PGP7,P14174,P00813,Q15392,P07602,P36551,O15118,Q05655,O14617,P08236,Q9NZ08,P61916,P49327,Q92766,P16278,Q14739,Q10713 21 +Diffuse cerebral atrophy 0.6221184248803517 1.9355432548388296 0.0529236660730514 1.0 0.1625715567895009 12 P07602,P16278,P31930,Q9NZJ7,Q10713 5 +Tetraplegia tetraparesis 0.4213815041104646 1.931236382896485 0.0534538265883834 1.0 0.1640899827599136 51 P00846,O95831,Q13423,P07602,O43681,Q7RTS9,P51970,P49773,Q9UBX3 9 +Azoospermia 0.6753551699924143 1.9249649446785264 0.054233743978679 1.0 0.1661498301140657 10 Q9BZH6 1 +Fulminant hepatic failure 0.6025109563119829 1.9230425629602603 0.0544747047186542 1.0 0.1666649221238505 3 P40939 1 +Demyelinating peripheral neuropathy 0.5960736888082729 1.9222577617251937 0.0545733319472097 1.0 0.1668551371558976 15 P00846,Q9NR77 2 +Psychosis 0.4962189018156811 1.9081294195002136 0.0563744911491099 1.0 0.1719027621515498 28 P00403,O00170,P26358,Q5JRX3,P55072,P50336,P36551,Q99497,P61916,Q6DKK2,O15118 11 +Intrinsic hand muscle atrophy 0.7129235748147793 1.9041602435365077 0.0568893177274927 1.0 0.173126600557669 5 Q9NR77 1 +Abnormal oral frenulum morphology 0.6082322308236321 1.8990364262641957 0.0575596867875627 1.0 0.1748179737403282 13 Q69YQ0,Q6DKJ4,O75844,O43924 4 +Symptomatic seizures 0.7206423407143083 1.8974651094727275 0.0577665794653077 1.0 0.175097771001797 8 P00367,Q13423,P40939,P53985,P31751 5 +Lateral clavicle hook 0.6564823283141894 1.896147359107254 0.0579405616980248 1.0 0.1753928246639284 4 Q9Y619,Q9Y5S9 2 +Sandal gap 0.5007643829422015 1.8942702143905616 0.0581891524526965 1.0 0.17591264912549 26 P61586,O75530,O95425,Q08J23,Q14739,Q9BV10 6 +Tibial bowing 0.7101391974580186 1.8913023220718272 0.0585839989162613 1.0 0.1769727899974024 5 Q7RTS9,Q9UPW6 2 +Submucous cleft of soft and hard palate 0.5335222877002442 1.891053807773149 0.0586171618169242 1.0 0.1769727899974024 21 Q7LGA3,Q08J23,Q15392,O75844 4 +Thin nail 0.6548252920949362 1.8879241156067164 0.059036138536892 1.0 0.178120241320603 4 O75530 1 +Depressed nasal tip 0.7089553452759908 1.8858306952186692 0.0593177731407958 1.0 0.1788520735608846 5 Q03164,Q96KP1,P21333 3 +Respiratory failure 0.3948749277306919 1.8793356603758884 0.0601986754223975 1.0 0.1810220152818359 62 P49815,P61916,Q9BUB7,Q15165,P06753,P07602,P40939,Q5SRE5,Q9Y619,Q9NZJ7,Q70HW3 11 +Abnormality of the mastoid 0.5943143320384218 1.878778422545738 0.0602747544875503 1.0 0.1810220152818359 3 Q15043 1 +Mastoiditis 0.5943143320384218 1.878778422545738 0.0602747544875503 1.0 0.1810220152818359 3 Q15043 1 +Paresthesia 0.5110951479346166 1.8784783136473024 0.0603157610366347 1.0 0.1810263857473292 24 P49773,Q9NR77,P05067 3 +Multiple joint dislocation 0.5941104221322717 1.8776748419344549 0.0604256603791641 1.0 0.1812373837191576 3 Q14807 1 +Ventricular hypertrophy 0.4664017394941438 1.8695391887371784 0.0615478367397348 1.0 0.1840002931141518 33 P00403,O00170,P10253,P11047,P06280,Q15233,P46777,P14854,O95425,O43772,P35573,P40939,Q9H267,O75844,Q9BV10 15 +Frequent falls 0.4465953599363776 1.8676750584915105 0.0618073771941116 1.0 0.1846555910035568 42 P00846,Q9NR77,P06753,P07602,O43681,P40939,Q7RTS9,Q9UHD1,P49773 9 +Cerebellar dysplasia 0.6503311258278075 1.8655889851627752 0.062098891864891 1.0 0.185284633680317 4 P60953,P42356,Q8NI27 3 +Narrow vertebral interpedicular distance 0.6498400625429384 1.86314565504611 0.062441776380326 1.0 0.1859440536712765 4 Q14807,Q96HY6 2 +Vertebral arch anomaly 0.6498400625429384 1.86314565504611 0.062441776380326 1.0 0.1859440536712765 4 Q14807,Q96HY6 2 +Cognitive impairment 0.3244646432281591 1.86205395198142 0.0625954858033399 1.0 0.1862148770157072 160 Q03164,P00403,P26358,Q14108,Q9NPF4,P35270,O43681,O60220,Q92947,Q96F07,Q9NZJ7,Q6PGP7,P49815,Q13057,O95831,P21333,Q9Y6K9,Q9UEY8,Q9BQE5,P15289,P06280,P07602,Q709C8,P05067,O15118,O15020,O75569,Q9Y487,Q99720,Q9NZ08,P50897,Q9BU61,Q99497,P13473,P61916,Q9H6K4,P00846,P49327,Q01968,P50542,P14854,P49770,P16278,O75503,Q9Y619,Q10713 46 +Psychotic mentation 0.7037895071016231 1.8619219593385803 0.062614091266588 1.0 0.1862148770157072 5 P00403 1 +Metaphyseal widening 0.5391991820695247 1.8581009099118293 0.0631546856575058 1.0 0.1875335356003997 20 O95831,P21333,Q14807,O75530,P16278,Q7RTS9,Q14739,Q9H9E3 8 +Kinetic tremor 0.4650296013006164 1.85780270629323 0.0631970366871226 1.0 0.1875335356003997 33 Q9BUB7,Q14108,P07602,O43681,P41440 5 +Cardiorespiratory arrest 0.7028636777727169 1.8576313906605857 0.0632213776341308 1.0 0.1875335356003997 5 Q9H0U9,P13473,O43772 3 +Aplasia hypoplasia of the femur 0.5676253898203796 1.8551214240541245 0.0635788890643986 1.0 0.1881466303436107 17 O95831,P50542,O00116,Q9BV10 4 +Sparse eyelashes 0.5846176768772585 1.8533361062570073 0.0638341990739159 1.0 0.1882602896713681 15 P48449,O75844,O75531 3 +Talipes calcaneovalgus 0.7572828617799484 1.853319571902228 0.0638365675267562 1.0 0.1882602896713681 6 Q9UBM7,Q9NR77,Q69YQ0 3 +Neoplasm of the gallbladder 0.7017923643837599 1.852664491804956 0.0639304624641492 1.0 0.1882945474249749 5 P07602,O43681,Q9NZJ7 3 +Biliary tract neoplasm 0.7017923643837599 1.852664491804956 0.0639304624641492 1.0 0.1882945474249749 5 P07602,O43681,Q9NZJ7 3 +Bone fracture 0.7015919647476978 1.85173513360201 0.0640638663023644 1.0 0.1885661196565416 5 Q13126 1 +Infectious encephalitis 0.6609421964746109 1.8512267545826735 0.0641369382909893 1.0 0.1886598756798574 10 Q9NZ08,Q9Y6K9,Q14739 3 +Supranuclear gaze palsy 0.5575286839950176 1.8495315502087064 0.0643810964043334 1.0 0.1892564407467142 18 P07602,O15118,Q99720 3 +Temporal pattern 0.7327142772745819 1.8444310536067745 0.0651203451657338 1.0 0.1909358933323483 7 Q9NR77 1 +Aplasia hypoplasia involving the sinuses 0.6460264900662166 1.844151988590213 0.0651609930926651 1.0 0.1909358933323483 4 P21333,P10644,A6NHR9 3 +Paranoia 0.6458694121940508 1.8433689409101508 0.0652751616547595 1.0 0.1911480581534449 4 P36551,O60220 2 +Polyneuropathy 0.5744050725934353 1.842409026517415 0.0654153424441696 1.0 0.1914360756822024 16 P00846,O95831,P31930,P07602 4 +Chorioretinal atrophy 0.6452038173895175 1.8400502652890696 0.0657608580302762 1.0 0.1918339370328707 4 P40939 1 +Chorioretinal degeneration 0.6452038173895175 1.8400502652890696 0.0657608580302762 1.0 0.1918339370328707 4 P40939 1 +Undetectable electroretinogram 0.6989516926044153 1.8394834412768888 0.0658441112258545 1.0 0.1919544567393224 5 O43924 1 +Cutaneous photosensitivity 0.5192572626573915 1.8366828158074608 0.0662567335413091 1.0 0.1927889824657163 22 Q14108,Q06136,P36551,Q08J23,P22830,Q9UBM7 6 +Abnormal corpus striatum morphology 0.5645413853425258 1.8356516548146504 0.0664091923295266 1.0 0.1929872211379324 17 Q13057,P00846,O95831,O60220,Q9BU61,Q92947 6 +Abnormal heart sound 0.6440904726233728 1.8344968421556864 0.0665802761201184 1.0 0.1933616267777804 4 Q01082,P10253 2 +Frontotemporal cerebral atrophy 0.5860637062831487 1.8340334113777568 0.0666490346925234 1.0 0.1934385743739251 3 Q9H9E3 1 +Abnormal peripheral myelination 0.4707929537867553 1.831084994591857 0.0670878578527598 1.0 0.1944655638961885 31 P00846,P26358,Q9NR77,P07602,O43681,O15269,Q9Y6X9 7 +Digenic inheritance 0.5852366765971437 1.8295379613941456 0.0673190578530893 1.0 0.1950122327807531 3 Q8NCM8,A6NHR9 2 +Adenoma sebaceum 0.6427112254064564 1.8276131865002456 0.0676076253440238 1.0 0.1956005696584053 4 P49815,P52701 2 +Angiofibromas 0.6427112254064564 1.8276131865002456 0.0676076253440238 1.0 0.1956005696584053 4 P49815,P52701 2 +Abnormal middle phalanx morphology of the hand 0.7284624001503521 1.825240527333147 0.0679647404944558 1.0 0.1962615881660092 7 Q03164,Q8IWS0,Q9UHX1,O60828 4 +Suicidal ideation 0.5842903300871003 1.8243916744818296 0.0680928797578217 1.0 0.1965076359719736 3 Q01082 1 +Central apnea 0.7281021350837827 1.8236130019310808 0.0682105995376562 1.0 0.1967233233042551 7 P07602,Q10713 2 +Abnormal midbrain morphology 0.7501094623138019 1.8221795830099967 0.0684277414520768 1.0 0.1972092863910323 6 Q96KP1,O43924 2 +Abnormality of the wrist 0.4690116384717826 1.8162724299206656 0.0693285922588218 1.0 0.1989671633531219 31 O95831,P21333,Q01968,P11047,Q14807,Q15125,P16278,Q7RTS9,Q6DKJ4,O75844,Q9BV10 11 +Metatarsus adductus 0.5939014355642178 1.8161061849102984 0.0693540851469434 1.0 0.1989671633531219 13 O96028,P50542,Q9H7D7,Q15392,P08236,Q08J23 6 +Diaphragmatic weakness 0.6938249398770334 1.8156549070357888 0.069423325294939 1.0 0.1989671633531219 5 Q9NR77 1 +Localized hirsutism 0.6396822018507397 1.8124806558352369 0.0699119602475231 1.0 0.2001169743920658 4 P36551,P21333 2 +Conical tooth 0.7254485371428608 1.811618020964908 0.0700452384676362 1.0 0.2003731602914818 7 P61586,Q9Y6K9,Q9UPW6 3 +Abnormal oral mucosa morphology 0.3914175888573937 1.8092395827879864 0.0704137906407298 1.0 0.2010504802012604 58 P49815,Q05655,P49327,Q01968,P49257,Q14108,Q9H7D7,Q15392,P78527,P08236,Q9NZ08,Q9UIG0,P53634,P16278,Q14739,P35250,Q6DKJ4 17 +Abnormality of the phalanges of the toes 0.584270313802061 1.803625772434463 0.0712899930150678 1.0 0.2027573792476422 14 Q7LGA3,Q6DKJ4,O75844 3 +Natal tooth 0.7236373429380184 1.803423745441664 0.0713216911926379 1.0 0.2027573792476422 7 Q69YQ0,O75844 2 +Abnormal pupil morphology 0.5840431721737172 1.802278159108977 0.0715016530380006 1.0 0.2031428094071562 14 P61586,Q9NR77 2 +Hyperactive deep tendon reflexes 0.6762934773006377 1.801836332400777 0.0715711596058441 1.0 0.2032141423796207 9 Q9NR77 1 +Delayed epiphyseal ossification 0.6356835575460128 1.792472709473714 0.0730572769171431 1.0 0.2068511562031543 4 Q14807 1 +Delusions 0.5393101359516066 1.7923428175213325 0.0730780685122352 1.0 0.2068511562031543 19 Q9BQE5,P15289,P07602,O43681,O60220,P50336,P36551,Q9NZJ7 8 +Adrenal hypoplasia 0.6968476985347878 1.785659213819594 0.0741544530171429 1.0 0.2092508825274126 8 Q9BZH6 1 +Muscle fiber necrosis 0.5211780277961717 1.7838600433923446 0.0744464099905473 1.0 0.20968690370876 2 Q96RR1 1 +Abnormality of visual evoked potentials 0.5117859747729753 1.7834072518665007 0.0745200336168092 1.0 0.2097651868783124 22 P15289,Q15067,P07602,O43681,O60220,O75503,Q9NZJ7 7 +Emg chronic denervation signs 0.564548606509703 1.7814124505450717 0.0748450957377995 1.0 0.210448639786856 16 P07602,O43681,P49773 3 +Incoordination 0.3762936449864996 1.7788946192241384 0.0752570404470298 1.0 0.2111903581398256 72 Q9Y619,P00846,Q9NR77,O75530,Q15067,P06753,P07602,O43681,P40939,Q7RTS9,Q9UHD1,P49773,Q9UGU0,Q10713 14 +Raynaud phenomenon 0.7398947097196478 1.7776890301259125 0.0754549423515302 1.0 0.2116159749650454 6 O75844 1 +Hammertoe 0.5630468284314297 1.7720926144159737 0.0763791847358292 1.0 0.2135759240193726 16 Q9NR77,P55072,Q99720,Q9UHD1,Q27J81,Q9UBM7,Q9Y6X9 7 +Severe short stature 0.5101964800991153 1.7720448848348234 0.076387106755454 1.0 0.2135759240193726 22 P10619,P16278,Q15392,Q7RTS9 4 +Teratoma 0.5739821251241273 1.7681804551643427 0.0770307405549521 1.0 0.2149815240975708 3 P20585,Q9BYW2 2 +Pericardial effusion 0.7151320908221983 1.7648671364997055 0.0775860980494118 1.0 0.216267704489743 7 Q14108 1 +Flared iliac wing 0.6828533196291289 1.7644915991910937 0.0776492484913848 1.0 0.2163119965581671 5 O95831 1 +Nail dysplasia 0.462754608294776 1.7641165390855655 0.0777123604664109 1.0 0.2163561276488825 31 O96028,Q9Y6K9,P10321,O75530,P42892,Q9Y619,Q6DKJ4 7 +Psychotic episodes 0.5727194668047713 1.7612759735617258 0.0781917045846571 1.0 0.2169960983006557 3 Q5JRX3 1 +Abnormalities of placenta or umbilical cord 0.5913199405246105 1.7606548093477823 0.0782968458266264 1.0 0.2170591540572193 12 P16278,Q6PGP7,O75844 3 +Unexplained fevers 0.735887703766182 1.7601900848046164 0.0783755825695677 1.0 0.2171459088504308 6 P07602,Q9HC07 2 +Abnormality of the odontoid process 0.691360595878099 1.7597229264450196 0.0784547966063764 1.0 0.2172338802585511 8 O95831,P08236,P16278,Q7RTS9,Q9H9E3 5 +Prenatal maternal abnormality 0.5825485203900066 1.749999723829332 0.0801183613821752 1.0 0.221171133924135 13 O43772,Q14739 2 +Abnormality of the 5th toe 0.7106033539729047 1.7442864300404015 0.0811091566835031 1.0 0.2229649310152516 7 Q14739,Q10713,O43924 3 +Postaxial foot polydactyly 0.7106033539729047 1.7442864300404015 0.0811091566835031 1.0 0.2229649310152516 7 Q14739,Q10713,O43924 3 +Abnormal circulating citrulline concentration 0.6251458123079673 1.739578182987079 0.0819331128960141 1.0 0.224824854751233 4 P00846 1 +Distal muscle weakness 0.3842506850994282 1.738855262597257 0.0820602251254059 1.0 0.225038736008977 60 P00846,O95831,Q9NR77,Q99720,P06753,P40939,O15269,P41440,P49773,Q9Y6X9 10 +Epidermoid cyst 0.568440142188623 1.7378454032814892 0.0822380579821455 1.0 0.2253088055765131 3 P49815 1 +Decreased specific antibody response to vaccination 0.6247798654700076 1.7377370429450931 0.0822571584265574 1.0 0.2253088055765131 4 Q9BV10 1 +Aplasia hypoplasia of metatarsal bones 0.7090380558669842 1.7371649454892055 0.0823580604570053 1.0 0.2254502647797329 7 P49773,Q9H9E3,Q7RTS9 3 +Increased circulating iga level 0.6763447223853909 1.7340348955667897 0.0829118917747648 1.0 0.22655983800185 5 Q05655,Q9Y6K9 2 +Distal peripheral sensory neuropathy 0.6234032662142204 1.7308086282962314 0.0834859024756831 1.0 0.2279922288968983 4 P40939 1 +Abnormal circulating iga level 0.5791467127166321 1.7301242769421228 0.0836080736434352 1.0 0.228178212010662 13 Q05655,Q9Y6K9,P00813,Q9BV10 4 +Central scotoma 0.6117271824447639 1.7275071910798918 0.0840766148280653 1.0 0.2289224664295391 11 Q9H061,P00846 2 +Chronic fatigue 0.706366738310483 1.7250021001147735 0.0845270940440872 1.0 0.229437763672835 7 P07602,Q13423 2 +Delayed cns myelination 0.4464233809101136 1.7238543292705988 0.0847341438485804 1.0 0.229619997865573 35 O95831,Q8IYI6,Q7LGA3,Q5SRE5,Q9Y3B2,Q9Y584 6 +Unusual infection by anatomical site 0.5627130857440696 1.7204491044156451 0.0853508376201395 1.0 0.2308810778885215 15 Q9NZ08,Q9Y6K9,Q14739 3 +Abnormality of tibia morphology 0.5698499368955503 1.7177852500066135 0.0858357928950044 1.0 0.2318277425329669 14 O95831,Q7RTS9,Q9BV10 3 +Abnormal b cell morphology 0.6095036694535207 1.7153953935282962 0.0862727593964534 1.0 0.2324134312875616 11 Q05655,P49327,P00813,Q9BV10 4 +Skin appendage neoplasm 0.5637206223104931 1.711951265577584 0.0869056499341618 1.0 0.2338431274242555 3 Q9UPY3,P35222 2 +Serositis 0.5176782778226697 1.711205386065147 0.0870432047619327 1.0 0.2340756452381704 20 P49327,P14174,Q92621,Q8NFH4,Q9NZ08,Q8N1F7,Q14C86 7 +Overlapping fingers 0.6799835414121196 1.7057722649885472 0.088050488889857 1.0 0.2365065068361945 8 P21333,Q8TD19,Q15125,P78527,Q9BV10 5 +Decreased calvarial ossification 0.6179391315575614 1.7032689941954808 0.0885177402370076 1.0 0.2374199117157403 4 O75844 1 +Abnormality of dental color 0.5620895957543212 1.70298969989307 0.0885699959874113 1.0 0.2374199117157403 3 P16278 1 +Lower limb amyotrophy 0.5429891351551831 1.6987468371289438 0.089366894341027 1.0 0.2393401260379642 17 P06753,P49773,Q9NR77 3 +Cholestatic liver disease 0.6686506728454008 1.6979331207117276 0.0895203852408683 1.0 0.2394002414571595 5 P40939,Q9UBM7,Q96NT0 3 +Duplication involving bones of the feet 0.5341880199152133 1.6978192700695802 0.0895418777463845 1.0 0.2394002414571595 18 Q92890,O96028,O43924,Q15125,Q92766,Q14739,Q9UBM7,Q10713 8 +Progressive psychomotor deterioration 0.654805030664683 1.6955767838879208 0.0899660575266949 1.0 0.2397056699119009 9 P07602,O43681,P16278,Q10713 4 +Limb ataxia 0.4864980296335662 1.695531022545339 0.0899747303711264 1.0 0.2397056699119009 24 Q14108,Q8IV08,Q9NR77,P41440 4 +Abnormality of the calcaneus 0.6774156565726299 1.6935637250254192 0.0903482160313207 1.0 0.2405606659542495 8 P40939,Q14739,Q7RTS9,Q9UPW6 4 +Muscular ventricular septal defect 0.6156749207194699 1.691839385705571 0.0906766017384179 1.0 0.2410144054336463 4 Q5SRE5 1 +Triangular mouth 0.6979857406778742 1.6867668419829844 0.0916481935999624 1.0 0.2433142587627773 7 Q6DKJ4,Q10713,Q86XI2,P11047 4 +Acne inversa 0.5588241664849701 1.685028673259268 0.0919830395699619 1.0 0.2440616649922989 3 Q92542 1 +Bifid tongue 0.6654491771314415 1.6828808156802166 0.0923981660973165 1.0 0.2450210928316441 5 P61978,Q9UBM7,Q6DKJ4 3 +Short chin 0.6519411595082093 1.6813484198352482 0.0926952580613527 1.0 0.2456665872303482 9 Q08J23,O75844 2 +Abnormality of the pulmonary veins 0.7175455097655905 1.679768557728743 0.0930023549413463 1.0 0.2463378348186008 6 O75718,Q15392 2 +Thin ribs 0.5704438382265127 1.6791420097773937 0.0931243705482443 1.0 0.2465183597451209 13 O95831,O75844 2 +Myotonia 0.6275869182337377 1.678787241338625 0.0931935160386587 1.0 0.2465587993693301 10 P49773 1 +Lower limb pain 0.7171961835089362 1.678232014405565 0.0933018142138011 1.0 0.2465960943173683 6 P00846 1 +Keratitis 0.5769441034116407 1.678162567242016 0.0933153671308022 1.0 0.2465960943173683 12 Q9NZ08,Q14739 2 +Hypoplasia of the odontoid process 0.6955650884084899 1.6757026560544823 0.0937964493252261 1.0 0.2474932792208341 7 Q7RTS9,O95831,P16278,P08236 4 +Achilles tendon contracture 0.5761471324783203 1.6735746175306714 0.0942142304454294 1.0 0.2483977723206973 12 P49773 1 +Sparse body hair 0.6263142207024739 1.6721616296196713 0.0944924545010701 1.0 0.248789347698094 10 P48449,Q9BZH6 2 +Erythroderma 0.6728842082513847 1.6719924064790526 0.0945258194553169 1.0 0.248789347698094 8 P48449,P00813 2 +Coxa vara 0.5690460204766731 1.6709359374165142 0.0947343321750677 1.0 0.2491948496352213 13 O95831,Q9Y487,Q7RTS9,P50542 4 +Atrial flutter 0.501985440105901 1.6683734998521162 0.0952416054969609 1.0 0.2502415777035546 2 O75694 1 +Aplasia of the phalanges of the hand 0.5019854401059007 1.668373499852114 0.0952416054969613 1.0 0.2502415777035546 2 Q9BXW9 1 +Abnormal astrocyte morphology 0.5613001742309195 1.6666287655458092 0.0955882453739165 1.0 0.2508643343328073 14 P00846,O95831 2 +Aplasia hypoplasia involving bones of the feet 0.3743903675965772 1.6658149369609785 0.0957502801254164 1.0 0.2511455771541724 65 Q03164,O96028,Q9Y4W2,Q13555,Q9UPW6,Q7LGA3,P00813,Q9UGU0,Q8IWS0,Q08J23,Q7RTS9,Q9UBM7,P49773,Q9H9E3,Q9UHX1,Q69YQ0 16 +Impaired proprioception 0.4321124303882606 1.6638067278385391 0.0961510590685272 1.0 0.2519080694657409 39 P00846,Q8IV08,Q9NR77,P41440,P49773,Q9Y6X9 6 +Aplasia hypoplasia of the uvula 0.6606317247812761 1.66019817795748 0.096874591088693 1.0 0.2529377321370219 5 Q01082,Q6DKJ4 2 +Vascular skin abnormality 0.3282506738865013 1.6590038399767206 0.0971150185233449 1.0 0.253129521515575 116 P00403,Q14108,Q15125,P35579,P22830,Q13126,P21333,Q9Y6K9,O00170,P06280,Q8IZA0,Q08J23,Q05655,Q9Y487,P10619,P09884,Q8NCH0,O75844,P00846,P49327,P49257,P28340,Q06136,Q92766,P16278,Q14739,Q9H9E3,Q9UBM7 28 +Clubbing of toes 0.5531281032770647 1.653637895936103 0.0982011080482521 1.0 0.2553786770095738 3 P38398,Q9BXW9 2 +Pyridoxine responsive sideroblastic anemia 0.5531281032770647 1.653637895936103 0.0982011080482521 1.0 0.2553786770095738 3 P38398,Q9BXW9 2 +Wide nasal ridge 0.6072847682119105 1.6493980874520302 0.0990661062959685 1.0 0.2574818674143374 4 P27635,P61978,Q15022 3 +Hand muscle weakness 0.5972420140560104 1.6484093164148332 0.0992687055284908 1.0 0.257715748839423 11 P49773,Q9NR77 2 +Abnormal renal cortex morphology 0.3866700787942402 1.6467749584128353 0.0996043103225192 1.0 0.2584404355703915 53 P00846,Q05655,P00403,P49327,Q01968,P11047,P06280,Q14108,Q92621,P00813,Q9NPF4,Q8NFH4,Q9NZ08,Q8N1F7,Q14C86,Q6PGP7 16 +Abnormality of the peripheral nervous system 0.3399793933334302 1.6440139002689085 0.1001733311552504 1.0 0.2594755725509797 100 O95831,Q9NR77,P42892,Q15125,Q99720,Q15067,P07602,O43681,O60220,Q6PJG6,P31930,O15269,P41440,Q9Y619,Q10713,Q9Y6X9 16 +Flared metaphysis 0.5962618715439295 1.643040980784238 0.1003744545893878 1.0 0.2594929807263312 11 P21333,Q14807,O75530,Q14739,Q9H9E3,Q96HY6 6 +Calcific stippling 0.6059454412275647 1.642610597467549 0.1004635267308409 1.0 0.2594929807263312 4 P50542 1 +Mucosal telangiectasiae 0.6658985072128639 1.6386713819194234 0.1012817172316937 1.0 0.2611641801518098 8 Q8IZA0,P10619,Q14739 3 +Acne 0.5565617238341635 1.6381979799639588 0.1013804008925252 1.0 0.2612714498226846 14 O00170,Q92766,Q9NZ08,Q9H488,Q92542 5 +Hypopigmented macule 0.6049137858538508 1.6373800372111171 0.101551086724327 1.0 0.26156405398832 4 P49815,Q9H488 2 +Cystoid macular edema 0.6042184718915878 1.633853629178375 0.1022895884068497 1.0 0.2630221607517704 4 P04439 1 +Upper motor neuron dysfunction 0.2684471709335732 1.6316376670122668 0.1027558383211606 1.0 0.2639245072929025 358 P00403,P26358,Q9NR77,P35270,O43681,O60220,O95298,Q7RTS9,Q9UHD1,P49773,Q9NZJ7,Q15043,P49815,P07737,O95831,Q9Y6K9,Q9UPW6,Q9Y4I1,Q5KU26,Q15392,Q15165,O75530,P07602,P09622,O15382,Q08J23,P41440,P51970,O15118,O75569,Q9BZH6,Q8IYI6,Q99720,Q9NZ08,P50897,P40939,Q96KP1,P09884,O60828,P61916,Q9UBX3,Q9Y6X9,P00846,Q86XL3,P50542,Q13423,Q15067,P16278,Q6PJG6,Q9Y619,Q9UGU0,Q10713 52 +Hip pain 0.6543294453527281 1.6304667268691158 0.1030028919302477 1.0 0.2644106765926773 5 O75844 1 +Exercise induced muscle cramps 0.6855347788461597 1.6297609363694492 0.1031520328427477 1.0 0.2646450977137088 7 P49773,P13473 2 +Abnormal circulating cholesterol concentration 0.4340897534640162 1.6293765853659967 0.1032333224105428 1.0 0.2647052754470894 36 Q8N511,Q01968,P61916,Q96NT0,Q15125,Q15392,Q13045,P07602,Q9H9E3,Q15800,Q14739,Q9NZJ7,Q9BV10 13 +Visual loss 0.4034823272333754 1.627492461046556 0.1036325484747544 1.0 0.2651348095969542 48 P48449,P00846,P04439,P00403,O00170,P50897,P07602,P40939,O60220,P09884,Q9NZJ7,Q10713 12 +Childhood onset 0.4301679416431215 1.6271085239570942 0.1037140509931777 1.0 0.2651950901652372 38 Q14566,Q9NR77,Q5JRX3,O95425,O60220,P09884,P22830 7 +Tremor 0.3124541405152258 1.625221289346589 0.1041154157400634 1.0 0.2659488217420837 158 P26358,Q14108,Q9NR77,P35270,O43681,O60220,Q15043,O95831,Q9Y4I1,Q9BUB7,Q5JRX3,P07602,P41440,O75569,Q9BZH6,O43924,Q99720,P31930,P00846,Q6PJG6 20 +Intestinal hypoplasia 0.6532093894053648 1.6251761266895863 0.104125035735594 1.0 0.2659488217420837 5 O75844 1 +Limb pain 0.6168630101807631 1.6228620238681633 0.104618903291378 1.0 0.2669612274492319 10 P00846,O15269,O75569 3 +Abnormal protein o linked glycosylation 0.6020346929173512 1.622772394368367 0.1046380690504527 1.0 0.2669612274492319 4 Q9H9E3,Q8N511 2 +Intestinal malrotation 0.4591011456764501 1.6214407320655404 0.1049231511505266 1.0 0.2675394221815935 29 O96028,Q15392,Q92766,Q14739,Q8NCH0,Q9UBM7,Q00839,Q9BV10 8 +Ovoid vertebral bodies 0.6835701077678673 1.6207446449724587 0.1050724145779304 1.0 0.2677708471732671 7 P16278 1 +Primitive reflex 0.7038681737414463 1.619477754096997 0.1053445091384663 1.0 0.2683148682953593 6 P26358 1 +Abnormality of the calf 0.3744354177767833 1.6183795374056102 0.1055808291109587 1.0 0.2686178181438901 59 O95831,Q9UPW6,O75718,Q7LGA3,Q9NR77,Q14807,P08236,Q9UIG0,P16278,Q7RTS9,Q9Y619,P35250,Q13126,Q9BV10 14 +Arteriovenous malformation 0.6515134011849498 1.6171613574434656 0.1058434552054323 1.0 0.2691363858195911 5 Q92990,P08236 2 +Overgrowth 0.6510680550807544 1.6150560335649813 0.1062985609888604 1.0 0.27014353894837 5 P61978,O75530,Q15022 3 +Generalized hyperpigmentation 0.5526626319980473 1.6147631494553418 0.1063619962045188 1.0 0.2701547484062611 14 Q9Y4I1,P09884,Q13423 3 +Moderately reduced visual acuity 0.5451939129790571 1.6097898870259026 0.1074437337202141 1.0 0.272599761218082 3 O60313 1 +Ankle clonus 0.5504399503365133 1.6013883901101127 0.1092909225673879 1.0 0.2766728720082602 14 P07602,O60220,Q15043 3 +Myocardial fibrosis 0.5976040174446947 1.6002630501056323 0.1095402402038385 1.0 0.2769622829365763 4 P13473 1 +Endocarditis 0.6478966545213776 1.600054785793456 0.1095864301599123 1.0 0.2769622829365763 5 Q9NZ08,P49327,P04062,P10644 4 +Acute encephalopathy 0.5975627447909724 1.6000532063733042 0.1095867805108454 1.0 0.2769622829365763 4 Q9Y619 1 +Uveitis 0.6120476044673848 1.5976805789105035 0.1101140831208946 1.0 0.2778347069704161 10 Q05655,P49327,O15484,P14174,Q9Y6K9 5 +Iris hypopigmentation 0.5966078547686986 1.5951973963074608 0.1106681008281307 1.0 0.2789250536841158 4 Q9Y4I1 1 +Abnormal proximal phalanx morphology of the hand 0.5957298537603326 1.59073117666528 0.1116700874482568 1.0 0.2809862508249979 4 Q14807 1 +Tall chin 0.5405494869248639 1.584059335492769 0.1131802170504143 1.0 0.2838497827067104 3 Q96L73,Q9BYW2 2 +Abnormal glomerular mesangium morphology 0.508181577406952 1.5837400775107746 0.113252880536999 1.0 0.2838764699988195 19 P11047,Q92621,P00813,Q8NFH4,Q9NPF4,Q8N1F7,Q14C86 7 +Gait ataxia 0.3636485124345028 1.5830791879950885 0.1134034165464306 1.0 0.28394333306945 69 P00846,Q8IV08,Q14108,Q9NR77,P07602,O43681,Q6PJG6,P41440,Q10713,O15118 10 +Abnormal pyramidal sign 0.3205426926576946 1.5830782529635865 0.1134036296375256 1.0 0.28394333306945 119 P26358,Q9NR77,O43681,O60220,Q9UHD1,Q15043,O95831,P07602,O15382,P41440,O75569,Q99720,Q9NZ08,P40939,Q9Y6X9,P00846,Q15067,Q6PJG6,Q9Y619 19 +Episodic vomiting 0.6077351999625593 1.5750951242680138 0.115234489322797 1.0 0.2877404569724178 10 P00846,P00403,Q2TAA5,P36551,Q9Y619 5 +Abnormal femoral head morphology 0.5063071769406948 1.5710887728805083 0.1161620300663772 1.0 0.2897184349145893 19 Q7LGA3,O95831,P16278,Q7RTS9 4 +Unconjugated hyperbilirubinemia 0.4857710125744651 1.569989479264141 0.1164175588945011 1.0 0.2900616042787869 2 P11413 1 +Areflexia of lower limbs 0.5060785153830032 1.5695447947040218 0.1165210503862899 1.0 0.2900746138776245 19 P49773,Q9NR77 2 +Abnormal sputum 0.6721997917014577 1.5684571051317406 0.1167744930949379 1.0 0.2904765515736581 7 P49815,Q9NZ08 2 +Deep plantar creases 0.6405912832901473 1.5654420805325664 0.1174792880759212 1.0 0.2919124329660648 5 Q9Y487,O00170 2 +Abnormal circulating acetylcarnitine concentration 0.690801567647464 1.561643913708535 0.118371898274999 1.0 0.2936521292166236 6 O43772 1 +Abnormal placenta morphology 0.6705794903877194 1.5609917449429858 0.1185256986295049 1.0 0.2937152802529745 7 P16278,O75844 2 +Airway obstruction 0.5436402437226395 1.560404117026936 0.118664412538562 1.0 0.2938999005351724 14 P06280,Q14807,Q92766,Q96HY6,P09601,O75844 6 +Microcytic anemia 0.626729040925403 1.5554776815964693 0.1198323459334103 1.0 0.2963371737160619 9 P22830 1 +Mental deterioration 0.3366389569678597 1.5519358919213395 0.1206775638073769 1.0 0.2982403939235227 94 Q03164,P00403,P26358,Q14108,O43681,O60220,Q92947,Q96F07,Q9NZJ7,Q13057,Q9BQE5,P15289,P07602,Q709C8,P05067,O15118,Q9Y487,P50897,Q9BU61,Q99497,P61916,P00846,P14854,P16278,O75503,Q10713 26 +Supernumerary tooth 0.6883274657710619 1.55066927347028 0.1209809616272412 1.0 0.2984081365572367 6 Q9UHX1,Q9UBM7,Q6DKJ4 3 +Hypopigmented skin patches 0.4564155733521542 1.5503111218660015 0.1210668591595187 1.0 0.2984081365572367 26 Q9Y6K9,Q8IZA0,Q15125,Q92766,P07602,P53634,Q9NZJ7 7 +Cholecystitis 0.6255305826688998 1.5494691173560975 0.1212689898291747 1.0 0.2987342122971652 9 P15289,O43681,Q9NZJ7,P07602 4 +Inappropriate crying 0.6674335875236661 1.5464876668567225 0.1219868363731198 1.0 0.3001794355267577 7 P07602 1 +Abnormal larynx morphology 0.4497629783833914 1.545863474059794 0.1221375435175304 1.0 0.3003887891884669 29 P27635,Q01082,Q92890,P21333,Q69YQ0,Q9UPW6,O75369,Q14807,Q92766,P43243,P07602,Q14739,Q9NZJ7,Q9UHX1,Q96HY6 15 +Neoplasm of the ear 0.5867477997634749 1.5449663415612251 0.1223544049608222 1.0 0.3005990936691807 4 Q9BYW2,Q15046 2 +Abnormal endocrine physiology 0.6359403331751233 1.5433662511906563 0.1227419373413107 1.0 0.3013894030102894 5 Q13423 1 +Arnold chiari type i malformation 0.6356073922081729 1.5417847997333285 0.1231258970083968 1.0 0.3021700968404462 5 Q15233,Q15043 2 +Limb muscle weakness 0.3542812475930942 1.5406006737585558 0.1234140038557825 1.0 0.3027148422550463 75 P00846,Q9NR77,Q99720,P06753,P40939,Q15067,Q7RTS9,Q14739,P49773,Q13126,Q9Y6X9 11 +Photophobia 0.4256708505897746 1.5403209708093597 0.123482134494766 1.0 0.3027197266108968 35 P48449,Q6P2Q9,P04439,Q9NZ08,P07602,P40939,O60220,P09884,Q9NZJ7 9 +Abnormal inflammatory response 0.2736451836400024 1.5388132365703309 0.1238498974704114 1.0 0.3031342142898786 234 O96028,P00403,P10321,P11717,O15484,P26358,P43034,Q92621,Q15125,O60220,O15269,P35579,P22830,P35250,Q92542,Q13126,Q6PGP7,P21333,Q9Y6K9,O15143,P14174,O00170,P00813,P78318,Q01130,P06753,Q08J23,Q15800,Q9BTW9,Q9BV10,P48449,Q9H4L7,P04439,Q05655,Q8ND04,P11182,P78527,P08236,Q9NZ08,P09884,Q8NCH0,Q9H488,Q9Y6X9,P49327,Q01968,Q9H7D7,Q8NFH4,Q06136,Q92766,Q13045,P53634,P16278,P08183,Q14739,Q9Y619,Q9UIG0,Q9UBM7,Q6DKJ4 58 +Diffuse mesangial sclerosis 0.5098535553066105 1.537924620828321 0.1240670465494382 1.0 0.3035034056957663 18 P11047,P00813,Q92621,Q8NFH4,Q9NPF4,Q8N1F7,Q14C86 7 +Bilateral cryptorchidism 0.6005789957334982 1.5375477693261703 0.12415922658462 1.0 0.3035666560244691 10 P48449,Q07864,P78318,O43924 4 +Pendular nystagmus 0.665084458648486 1.5356489454454207 0.1246245029481596 1.0 0.3044803823971338 7 P00846 1 +Abnormal diaphysis morphology 0.3644112919018784 1.535479902332467 0.1246659900835107 1.0 0.3044803823971338 64 O00170,Q9HC07,Q9UPW6,O75718,Q7LGA3,Q9NR77,Q14807,Q9Y487,P08236,Q9UIG0,P16278,Q7RTS9,Q14739,Q9Y619,P35250,Q13126 16 +Tinnitus 0.5459121269105878 1.534482286831542 0.1249110476518344 1.0 0.3047536594362721 13 O95831,Q9NR77 2 +B lymphocytopenia 0.6440496795069914 1.5339726730669152 0.1250363757139729 1.0 0.3048969055103113 8 P00813 1 +Caesarian section 0.5843312425217784 1.5326312693100868 0.1253667324885574 1.0 0.3055396882854779 4 P33991,O60313 2 +Abnormal nervous system electrophysiology 0.3033855017318763 1.5284757557302835 0.1263944585064382 1.0 0.3074622338370674 171 O96028,P00403,Q14108,Q9NR77,Q15125,O43681,O60220,O15269,Q5SRE5,Q9NZJ7,O95831,Q9BQE5,Q2TAA5,P07602,Q08J23,Q00839,P48449,Q8IYI6,Q99720,P50897,P31930,Q96N66,Q9UBX3,Q9Y6X9,P50542,Q15067,Q9Y619 27 +Confusion 0.5163137094541955 1.527481202888068 0.1266413978705554 1.0 0.3076633110687538 17 P26358,Q9NZ08,P40939,P36551,Q9Y619,P05067 6 +Facial hemangioma 0.5829087587502608 1.5253661083926895 0.1271678071858915 1.0 0.3081244327632744 4 Q9UBM7 1 +Abnormal femoral neck morphology 0.4219830670845584 1.5209574067787806 0.1282705263247536 1.0 0.3099986664927523 36 O95831,P50542,Q9Y487,O75718,O75530,Q14807,P16278,Q7RTS9,Q9Y619,Q9H9E3,O75844 11 +Decreased number of peripheral myelinated nerve fibers 0.5369788206268596 1.520160229788681 0.1284707101051689 1.0 0.3102957467817194 14 Q9NR77,P26358 2 +Synostosis involving digits 0.5817927285322276 1.519663965374295 0.1285954525470676 1.0 0.3104332206265445 4 O60828 1 +Psychomotor deterioration 0.6188790999923132 1.5160839077822248 0.1294981368349554 1.0 0.3117900958935251 9 P07602,Q9Y487,Q9NZJ7,P50897 4 +Fused cervical vertebrae 0.6802385623508682 1.5147385863989946 0.1298386185185105 1.0 0.3123968825366981 6 Q9UHX1,P21333,Q9Y5S9 3 +Calvarial hyperostosis 0.6296999112779291 1.5137001846723186 0.1301018981066914 1.0 0.3125860302542398 5 P22626,Q15043,P55072 3 +Prolonged partial thromboplastin time 0.6796315381588809 1.5120392339948303 0.1305238818673704 1.0 0.3130734958709606 6 Q9BV10 1 +Abnormal sternal ossification 0.5802039628533479 1.5115432545971794 0.1306500968502351 1.0 0.3130734958709606 4 Q9Y619 1 +Abnormal iliac wing morphology 0.5480844172879527 1.5111460153645604 0.1307512530700987 1.0 0.3130734958709606 12 O95831,P16278,O75530,Q7RTS9 4 +Abnormal circulating igg level 0.528625876563345 1.5111330906362903 0.1307545453479117 1.0 0.3130734958709606 15 Q05655,P49327,Q9Y6K9,P17812,P00813,Q9BV10 6 +Laryngomalacia 0.5354863135729543 1.5111316746258556 0.1307549060479709 1.0 0.3130734958709606 14 P07602,Q9NZJ7,Q9UPW6 3 +Dry skin 0.4460373893637565 1.50872089238353 0.1313701241375706 1.0 0.3143131511644856 28 P00813,Q2TAA5,Q8ND04,Q06136,Q96KP1,Q08J23,Q6PGP7,Q9H4L7 8 +Abnormality of the larynx 0.4003794057390787 1.5030571873805112 0.1328242976604636 1.0 0.3171292698966835 45 P07737,Q92890,P21333,Q69YQ0,Q9UPW6,Q14807,Q15165,Q92766,P55072,Q92804,P07602,Q9UBM7,Q14739,Q9NZJ7,Q9UHX1,Q96HY6 16 +Mesomelia 0.6577945479406158 1.501971384357568 0.1331044992271068 1.0 0.3176325823579083 7 Q9UBM7,Q6DKJ4,Q14739 3 +Peripheral demyelination 0.5042851117736592 1.5011285886408947 0.1333223057378278 1.0 0.3179865520385816 18 P00846,O43681,Q9NR77,P07602 4 +Limb girdle muscle atrophy 0.5458218818969132 1.497983611049357 0.134137508571271 1.0 0.3195978015256156 12 P06753,Q9Y6X9,Q8WXH0,P55072 4 +Thickened ribs 0.5771496497338533 1.4959212825019188 0.1346741695333257 1.0 0.3207095077804537 4 P16278 1 +Small earlobe 0.6357246999511924 1.4939072760973942 0.1351998564174141 1.0 0.3216266854586822 8 P10586,P52788,P98175,Q92766 4 +Milia 0.5241712455194164 1.4929827234143032 0.1354417093300215 1.0 0.3220346512226019 3 Q9H4L7 1 +Pleural effusion 0.5445344320622082 1.4904899570415415 0.1360954551857016 1.0 0.3234210271988351 12 Q9NZ08,P14174,Q14739 3 +Brachydactyly 0.3560224391488323 1.4878587118498785 0.136788158208952 1.0 0.3243077003096148 69 P48449,O95831,Q13555,O43924,P61586,Q08J23,Q7RTS9,Q14739,Q6DKJ4 9 +Hemoptysis 0.6741682878477575 1.4877272176209684 0.1368228466895054 1.0 0.3243077003096148 6 P49815,Q9NZ08 2 +Scotoma 0.5311105743619033 1.4846383203094324 0.1376396586955355 1.0 0.3260749057191853 14 Q9H061,P00846,O60220 3 +Rigidity 0.3639056872759264 1.483508280258611 0.1379394181352324 1.0 0.3264471131359663 55 Q13057,P00846,Q9Y4I1,P15289,Q15392,P35270,P07602,O43681,Q96CU9,Q92947,Q96F07,Q709C8,P31930,Q99497,Q9H6K4,Q9NZJ7,Q6PJG6,P16278 18 +Distal upper limb amyotrophy 0.5431757531105301 1.482578759324962 0.1381863639596066 1.0 0.3266936920677269 12 Q9NR77 1 +Aplasia hypoplasia of the earlobes 0.6120203913881436 1.4815958732932262 0.1384478577306536 1.0 0.3271429245395981 9 P10586,P52788,P98175,Q92766 4 +Osteolysis involving bones of the upper limbs 0.6323299266103404 1.477545246524728 0.1395295390050428 1.0 0.3290194229912834 8 O75844,O75531 2 +Abnormality of the tonsils 0.6321103891002502 1.4764866705893218 0.1398132909599472 1.0 0.3293491676395668 8 P00813,P31751 2 +Increased connective tissue 0.6316407183048117 1.4742218084631262 0.1404218798591658 1.0 0.3303841138800555 8 O95831 1 +Chronic hepatic failure 0.572668353153265 1.472977003621559 0.1407572366998901 1.0 0.3305675092817652 4 P40939 1 +Hypoglycemic coma 0.6091923146900156 1.4673580724963955 0.1422786737786623 1.0 0.3337824140876153 9 P40939,Q13423,P31751,P00367 4 +Abnormal circulating non proteinogenic amino acid concentration 0.6495229570138903 1.4636862574033005 0.1432796920965129 1.0 0.3354430438494832 7 P00846,P05067 2 +Impaired vibratory sensation 0.4329631974872466 1.4591012444854643 0.1445372437740331 1.0 0.3375239616090558 30 P49773,Q9NR77,P00846,Q9Y6X9 4 +Alopecia 0.4033111356973279 1.4567160859755182 0.1451947675590803 1.0 0.3385436945540235 42 P48449,Q9Y6K9,P00813,P61586,Q6DKJ4,O75844 6 +Pain 0.3000114055636965 1.455326726483541 0.1455788309780521 1.0 0.3392639049829656 170 Q14108,Q9NR77,O15269,Q9NZJ7,Q15043,Q70HW3,P49815,P07737,P14174,Q15165,P07602,Q15800,O75569,Q14566,P42892,O95425,Q9NZ08,P40939,O75844,P00846,Q8NFH4,Q13423,Q14739 23 +Nasogastric tube feeding in infancy 0.6066711847770041 1.4546576149505692 0.1457640720969681 1.0 0.3395227267113604 9 P06753,P07602,Q9NZJ7,Q9UPW6 4 +Homocystinuria 0.4665784248841916 1.452718410051598 0.1463019533008192 1.0 0.3402607140576162 2 P51610 1 +Rheumatoid factor positive 0.5687145303135154 1.4527112954391166 0.1463039294877406 1.0 0.3402607140576162 4 Q05655 1 +Abnormality of the spleen 0.3200042943444994 1.4519185037460138 0.1465242668634496 1.0 0.3406000860507918 111 P15586,O96028,P14174,Q14108,P00813,Q15392,Q9NZJ7,Q9NZ08,P07602,P10619,P16278,Q96KP1,Q14739,P61916,Q10713,O15118 16 +Postaxial hand polydactyly 0.5833653735698963 1.4469203618171484 0.1479192295630302 1.0 0.343668179548218 10 Q9UBM7,Q14739,Q10713,O43924 4 +Agitation 0.4161502245886332 1.4440808439964563 0.1487162358381293 1.0 0.3448197626297457 34 P48449,P42892,P05067,Q15165 4 +Sparse or absent eyelashes 0.4589490960352078 1.4427224724165852 0.1490986661520208 1.0 0.3451818892148707 23 P48449,O75531,O75844 3 +Abnormal upper limb bone morphology 0.3279840403591378 1.441813591418819 0.1493549676086485 1.0 0.3455851766841154 97 O96028,Q7RTS9,P35250,P98175,Q9UPW6,Q7LGA3,O75530,Q14807,Q08J23,Q9BV10,O43924,P08236,O60828,Q9UHX1,O75844,O75531,P50542,Q9UIG0,P53634,P16278,Q9H9E3,O00116,Q14739,Q9UGU0,Q6DKJ4 25 +Porphyrinuria 0.5147366553336551 1.4403069941775484 0.1497805634938434 1.0 0.3455851766841154 3 P36551 1 +Respiratory paralysis 0.5147366553336551 1.4403069941775484 0.1497805634938434 1.0 0.3455851766841154 3 P36551 1 +Elevated urinary dicarboxylic acid level 0.5147366553336551 1.4403069941775484 0.1497805634938434 1.0 0.3455851766841154 3 P36551 1 +Astrocytosis 0.6625651773740501 1.435994078554227 0.1510040262301912 1.0 0.3480087754559846 6 P00846 1 +Short long bone 0.4150236287331346 1.4341251703645206 0.1515365462124367 1.0 0.3488827418313727 34 P98175,P50542,P16278,O00116,Q7RTS9,P49773,Q9BV10 7 +Hyporeflexia 0.3162990124051281 1.4329316534873389 0.1518773702900275 1.0 0.3490705451946958 114 P00846,O95831,P26358,P50542,Q9NR77,Q99720,P06753,P07602,O43681,P40939,Q15067,O15269,P41440,Q9Y3B2,Q10713,Q9Y6X9 16 +Short femur 0.66132922266083 1.4304763012093695 0.1525803628409976 1.0 0.3500552986081434 6 O00116,Q9BV10 2 +Hypointensity of cerebral white matter on mri 0.6610538929890529 1.429246947853924 0.1529332682872173 1.0 0.3506560634252412 6 P07602 1 +Steppage gait 0.476914898260269 1.4290305724426042 0.1529954465064904 1.0 0.3506560634252412 20 Q9NR77 1 +Abnormal erythrocyte sedimentation rate 0.6222175979227016 1.4287315695398295 0.1530814004296394 1.0 0.3506741742026608 8 Q05655,P14174 2 +Hypocholesterolemia 0.6012886539509311 1.4275189311472003 0.1534303723984085 1.0 0.3511101972321651 9 P07602,Q15800,Q9BV10 3 +Cherry red spot of the macula 0.6012264403740791 1.4272050718485747 0.153520793015077 1.0 0.3511101972321651 9 P07602,P10619,P16278 3 +Metaphyseal dysplasia 0.5795932234175621 1.4270095225568855 0.1535771498489828 1.0 0.3511101972321651 10 O95831,Q7RTS9 2 +Abnormal full field electroretinogram 0.6413982338497439 1.4260136508025132 0.1538644017472956 1.0 0.3511480612656926 7 P00846,P50897 2 +Abnormal light and dark adapted electroretinogram 0.6413982338497439 1.4260136508025132 0.1538644017472956 1.0 0.3511480612656926 7 P00846,P50897 2 +Retinal detachment 0.5211111216586904 1.4239765787434715 0.1544532520978867 1.0 0.3520480133437585 14 P49327,Q9Y6K9,O15484,P04439,Q8NCH0,Q9BV10 6 +Steroid resistant nephrotic syndrome 0.6107865183287089 1.42350379580358 0.1545901625364303 1.0 0.3520480133437585 5 Q92621 1 +Tetraplegia 0.5208844839966591 1.4225999478503517 0.1548521591347613 1.0 0.3524407420983604 14 O95831,P15289,P43034,Q13423,O43681,P51970,Q9BTW9 7 +Aplasia hypoplasia involving the femoral head and neck 0.5555699500051069 1.4186436157259197 0.1560029432539424 1.0 0.3543550725922058 11 O95831,O00443,Q96HY6,P50542 4 +Spondyloepimetaphyseal dysplasia 0.5776007397142516 1.4164860354665083 0.1566332499047229 1.0 0.3554340033782434 10 O95831,Q14807,Q7RTS9,Q96HY6 4 +Schizophrenia 0.4662229717803706 1.4154605276582402 0.1569335137931005 1.0 0.3557626016003076 21 Q9BQE5,Q92766,P07602,O43681,Q9NZJ7,Q9BUK6 6 +Bilateral sensorineural hearing impairment 0.4551902485636391 1.4147567501926757 0.1571398288997905 1.0 0.3560539588486837 23 P07602,O43681,P00403,Q15067 4 +Aplasia hypoplasia of the skin 0.3574800079520018 1.4114246873191807 0.1581194278872826 1.0 0.3576441982715888 56 O96028,O00170,Q9UPW6,Q15392,Q15125,P53634,O15111,Q8NCH0,Q9Y619,Q13126,O75844,Q9H4L7 12 +Abnormal metacarpal morphology 0.4331684124640517 1.410892899434133 0.1582761961664924 1.0 0.3577432838785363 29 O43924,Q14807,P08236,P16278,Q14739,Q7RTS9,O60828,Q9H9E3 8 +Abnormality of the metacarpal bones 0.4110809088333565 1.410370490778672 0.1584303140698129 1.0 0.3577553590221087 35 O96028,O43924,Q14807,P08236,P16278,Q14739,Q7RTS9,O60828,Q9H9E3,Q9UBM7 10 +Abnormal circulating androgen level 0.5540723407765638 1.4103381391956162 0.158439861976692 1.0 0.3577553590221087 11 Q13423,Q9BZH6 2 +Reticulated skin pigmentation 0.4596293845135791 1.4100801095483446 0.1585160297349435 1.0 0.3577553590221087 2 Q9NX24 1 +Generalized muscle weakness 0.4336821274543745 1.4089972952964758 0.1588359678985704 1.0 0.35830075163714 28 P07737,O95831,P10253,P11047,P31040,Q15165,P55072,P06753,Q92804,P40939,P49792,Q9Y6X9 12 +Poor coordination 0.5760498136152701 1.4082917758720834 0.1590446899058073 1.0 0.3583999430056797 10 Q9Y619,O75530 2 +Abnormality of the septum pellucidum 0.3957518023190925 1.406673718254647 0.1595241624435543 1.0 0.3589685798938782 43 O96028,Q69YQ0,Q9BZH6,Q8ND04,Q15392,Q08J23,Q96N66,Q9BV10 8 +Aplasia hypoplasia involving the skeletal musculature 0.6175560029065427 1.4061954774923449 0.1596660867425998 1.0 0.3591113901822504 8 P06753,Q9NR77 2 +Aphthous ulcer 0.6365446844320192 1.403480527139547 0.1604735947617825 1.0 0.3604451601690817 7 Q9NZ08,Q05655,P78527 3 +Abnormal circulating carboxylic acid concentration 0.3271128523704433 1.3954465604928843 0.1628812190872501 1.0 0.3645512663874543 90 P43034,Q99797,P35270,O95298,Q92947,P00390,Q6PGP7,Q9BUB7,O15382,P09622,P36551,P55263,P41440,Q9H267,P05067,P32929,P11182,P22695,P00846,P23378,Q14739,Q9Y619 22 +Abnormal phalangeal joint morphology of the hand 0.4062079589237892 1.3926119831511934 0.1637371573726431 1.0 0.366108924911865 37 Q9Y6X9,Q9Y6K9,Q01968,Q9BUB7,O75530,Q9NPF4,Q6DKJ4,Q9Y619,P49773,O75844,Q9H4L7 11 +Functional abnormality of male internal genitalia 0.431956640575344 1.3902810067017333 0.1644435630744933 1.0 0.3673295208355081 27 O00170,Q9BZH6,Q13423,Q9UIG0,P09884,P35250 6 +Abnormal bone structure 0.2959222640607348 1.3890811669214072 0.1648080698909662 1.0 0.3676055243133296 172 O96028,Q14108,Q15125,P42695,Q7RTS9,Q9NZJ7,Q13126,Q15043,O95831,Q9Y6K9,O00170,Q15392,O75530,P07602,Q9BV10,Q9BZH6,O75844,Q86XL3,Q9HC07,O75531,P50542,P53634,P16278,O00116,Q14739,Q9Y619 26 +3 4 finger syndactyly 0.4556585043017948 1.3856810018291916 0.1658443318242046 1.0 0.3688384386585931 2 P14923 1 +2 3 finger syndactyly 0.4556585043017948 1.3856810018291916 0.1658443318242046 1.0 0.3688384386585931 2 P14923 1 +Hypovolemic shock 0.4556585043017948 1.3856810018291916 0.1658443318242046 1.0 0.3688384386585931 2 P14923 1 +Genetic anticipation 0.4553275976174839 1.3836467266224617 0.1664666532168612 1.0 0.3698630445502787 2 Q9UBB4 1 +Aplasia hypoplasia of the proximal phalanges of the hand 0.4546657842488535 1.3795777309986423 0.1677166978940982 1.0 0.3715582411719689 2 Q9BXW9 1 +Neoplasm of the small intestine 0.5543703330904395 1.379036577675082 0.1678834764953354 1.0 0.3717477851568215 4 P31040 1 +Tracheomalacia 0.524872154449704 1.3757441451132084 0.1689008594717691 1.0 0.373458567054245 12 P63000,P19367,P46777,Q9H7D7,Q14807,O75369,Q9Y4A5,Q9H2M9 8 +Squamous cell carcinoma of the skin 0.5534702835703359 1.374406822651918 0.1693154192373249 1.0 0.3740138387303264 4 Q9H4L7 1 +Duodenal stenosis 0.5533112582781335 1.3735887400749442 0.1695693945331791 1.0 0.3743941721072652 4 P38398,O75419,Q9BXW9 3 +Aplasia involving bones of the extremities 0.5021516054286723 1.3698485894503116 0.1707341707711593 1.0 0.3766025540335405 3 Q8NCM8,Q9BXW9 2 +Abnormality of amino acid metabolism 0.4526803441429638 1.3673672997736184 0.1715102066488238 1.0 0.3775864434014752 2 P19447 1 +Flat nasal alae 0.4526803441429638 1.3673672997736184 0.1715102066488238 1.0 0.3775864434014752 2 P19447 1 +Abnormality of head blood vessel 0.4428295262002675 1.3655606724309957 0.1720768974847435 1.0 0.3786519037440726 24 P00846,Q92766,Q9UIG0,P07602,P10619,P16278,Q9NZJ7 7 +Abnormal femoral neck head morphology 0.3887103325518905 1.3618193428861354 0.1732549055971133 1.0 0.3806950086020104 44 O95831,P50542,Q7LGA3,Q9Y487,O75530,Q14807,O75718,P16278,Q7RTS9,Q14739,Q9Y619,Q9H9E3,O75844 13 +Aplasia hypoplasia of the vagina 0.4516876240900153 1.3612602285771156 0.1734314667523704 1.0 0.3807174212592852 2 P30153 1 +Elevated circulating follicle stimulating hormone level 0.4516876240900141 1.3612602285771085 0.1734314667523726 1.0 0.3807174212592852 2 P16435 1 +Skeletal dysplasia 0.38860792266388 1.360813313448742 0.17357269351097 1.0 0.3808447834130919 44 O95831,Q9HC07,Q9BZH6,P10619,P16278,Q7RTS9,Q14739 7 +Abnormal cellular phenotype 0.2916311413429924 1.3587265261931425 0.1742332632132428 1.0 0.3817572022801226 179 P15586,P00403,P26358,Q14108,P09601,O60220,O95298,Q9Y584,Q9NZJ7,Q70HW3,Q9Y6K9,P14174,Q9BUB7,P00813,O43772,P07602,P09622,P51970,Q9BV10,Q86Y39,P40939,Q9UBX3,O75844,P00846,P50542,Q14739 26 +Peripheral axonal neuropathy 0.3523566760473586 1.3543150516703824 0.1756358861299034 1.0 0.3840828718664921 57 P00846,O95831,P00403,Q8IV08,Q15067,P07602,O15269,P49773,Q9Y6X9 9 +Abnormality of the gingiva 0.3823972107939665 1.351036706665246 0.1766836746013795 1.0 0.3851746149513613 46 P49815,Q01968,P49257,Q14108,Q9H7D7,Q15392,P08236,Q9UIG0,P53634,P16278,Q14739,P35250,Q6DKJ4 13 +Neonatal hypoglycemia 0.5652010673491016 1.350910182184552 0.1767242061170764 1.0 0.3851746149513613 10 P40939,O43772 2 +Abnormal retinal artery morphology 0.4519675986787994 1.35024510144226 0.1769373755116916 1.0 0.3854556724021954 22 P00846,Q92766,Q9UIG0,P07602,P10619,P16278,Q9NZJ7 7 +Cessation of head growth 0.6426716614344382 1.347042780174707 0.177966454998617 1.0 0.386777048684079 6 P49770,Q9Y263,Q13144 3 +Hypokinesia 0.5142421848091866 1.3461196076973314 0.178263946097082 1.0 0.3872397158454412 13 P06753,O95831,Q2TAA5 3 +Fever 0.3219190154946427 1.34513305298831 0.1785822709308981 1.0 0.3877471793409492 79 P49815,P00846,P00403,Q9HC07,P14174,P00813,Q9NR77,Q8NFH4,Q9NZ08,P07602,Q14739 11 +Inflammation of the large intestine 0.5139170889839682 1.3441796288850094 0.1788903073944796 1.0 0.3882318335441125 13 Q05655,P49327,P09884,P08183,Q6PGP7 5 +Upper limb amyotrophy 0.501400555687253 1.3423260856147574 0.1794902890080623 1.0 0.3893493141184366 15 P49773,Q9NR77 2 +Clumsiness 0.4556392854785763 1.3395985143813385 0.1803759070766888 1.0 0.3903454026903095 21 Q9NR77,Q15067,P06753,P07602,O43681,Q9NZJ7 6 +Gastritis 0.6403153346284101 1.3364901747395894 0.1813891098110769 1.0 0.3921671967904105 6 Q05655,Q6PGP7 2 +Abnormality of the upper arm 0.438853527546204 1.335297613606392 0.1817789593752383 1.0 0.3928245028614098 24 Q9Y6X9,O00116,Q7RTS9,Q9BV10 4 +Hypoketotic hypoglycemia 0.6026176286354807 1.3338614030279712 0.1822492829259774 1.0 0.39326722175703 8 P40939,O43772 2 +Generalized joint laxity 0.5062765854078022 1.3337405179202702 0.1822889109568484 1.0 0.39326722175703 14 Q9BZH6,Q9UPW6,Q9Y487,Q14807,Q9UHX1,Q9BUK6 6 +Abnormal morphology of the conjunctival vasculature 0.6395153963364935 1.3329070914084418 0.1825622951251677 1.0 0.3935881416805901 6 P06280,P10619,P12004,O00462 4 +Keratoconjunctivitis 0.5609294564976651 1.328291447501833 0.1840818440127325 1.0 0.3958906666031487 10 Q9NZ08 1 +Arteriosclerosis 0.5044678109173121 1.3227234687519374 0.1859273559669474 1.0 0.3993381080528945 14 P61916,O75844,O15118,O75531 4 +Nephrotic syndrome 0.4364389251763408 1.3169096203419175 0.1878689213867983 1.0 0.4025839637105602 24 Q05655,P11047,P06280,Q92621,Q14108,P00813,Q9NPF4,Q8NCH0 8 +Cerebral dysmyelination 0.6168072148496616 1.3116768059760449 0.1896292058189375 1.0 0.4057216110083302 7 P07602 1 +Hypoplastic vertebral bodies 0.6341185513014418 1.3087261134421069 0.1906271428247263 1.0 0.4073298005176343 6 P16278 1 +Lymphocytosis 0.5401409315802578 1.305770050083627 0.1916307679481881 1.0 0.4090923623595415 4 Q05655,P49327 2 +Vertical supranuclear gaze palsy 0.5557669253915977 1.300941010135125 0.1932786472454117 1.0 0.411458776019651 10 O15118 1 +Avascular necrosis 0.450135641053612 1.3000957438987988 0.1935681562191105 1.0 0.4118835197651644 21 Q9NZ08,Q14108,O75844 3 +Impaired temperature sensation 0.6321026431613823 1.2996907588109392 0.1937069789311283 1.0 0.4119873803753598 6 Q9NR77 1 +Increased serum pyruvate 0.4134871729967276 1.2968630714273963 0.1946783046697282 1.0 0.4132850651546132 30 Q9Y6M9,O95831,Q86Y39,Q9BWD1,Q5JRX3,P22695,O75251,Q96CU9,Q70HW3 9 +Abnormal circulating proline concentration 0.5381579780110195 1.295550048163456 0.1951305480856551 1.0 0.4140530916031726 4 O95298 1 +Gastrointestinal infarctions 0.439774983454676 1.2878973404595533 0.1977817014070275 1.0 0.4185144925288789 2 P01889 1 +Glossitis 0.439774983454676 1.2878973404595533 0.1977817014070275 1.0 0.4185144925288789 2 P01889 1 +Aplasia hypoplasia involving the vertebral column 0.4921536488959807 1.2848026129088137 0.1988612690719993 1.0 0.4204101748464391 15 O95831,P16278,Q14739 3 +Impaired pain sensation 0.4635994176746909 1.2809227097563889 0.200220815235939 1.0 0.4225863625326534 19 Q9NR77 1 +Increased blood urea nitrogen 0.4384513567174147 1.2797391488784122 0.2006368912238993 1.0 0.4229917324420946 2 Q16658 1 +Focal dystonia 0.4470781868671737 1.278140583088417 0.2011998617355677 1.0 0.4235932691645324 21 P49773,O60220,Q15043,Q99720 4 +Red green dyschromatopsia 0.4856101839351208 1.2770059250566057 0.2016001554494932 1.0 0.4239413316655608 3 Q9H6K4 1 +Decreased plasma carnitine 0.5077065401673032 1.2752426094513978 0.2022233840200424 1.0 0.4245763434218965 12 P09622,O43772 2 +Oculomotor apraxia 0.4465483153622844 1.274335130775864 0.2025446712129031 1.0 0.4250559193679309 21 P35270,P05067,O43924 3 +Bowing of the legs 0.3627588159661465 1.270285916364866 0.2039828030350863 1.0 0.4278777678696563 50 Q9UPW6,Q7LGA3,O75718,Q9NR77,Q14807,P08236,Q9UIG0,P16278,Q7RTS9,Q9Y619,P35250,Q13126 12 +Abnormality of temperature regulation 0.3160272877731402 1.269468022653035 0.2042741885829802 1.0 0.4282926986460377 98 P49815,P00846,P00403,Q9HC07,P14174,P00813,Q9NR77,Q8NFH4,O43772,Q9NZ08,P07602,P35270,Q14739,Q9NZJ7 14 +Progressive inability to walk 0.4540211955638971 1.269086654361066 0.204410159596053 1.0 0.4283815478347686 20 P49773,P00846 2 +Myoclonic spasms 0.6251285116440957 1.2684232818392605 0.2046468317293173 1.0 0.4286725033757378 6 P00846,Q6PJG6 2 +Broad ribs 0.578152568058793 1.267162801427927 0.2050970836705332 1.0 0.4291573860846264 5 P16278 1 +Diaphragmatic paralysis 0.5326200214463774 1.266999634041024 0.2051554207457204 1.0 0.4291573860846264 4 P60174,Q9Y6X9 2 +Opisthotonus 0.4233195029189232 1.2607455145230402 0.2074005498980358 1.0 0.4334576789421506 25 P43034,Q2TAA5,Q99720,P07602,P51970,Q9NZJ7 6 +Abnormal sensory nerve conduction velocity 0.6229738408130244 1.2587610105369638 0.2081166671285117 1.0 0.4343593184893745 6 Q9NR77 1 +Tremor by anatomical site 0.4226589732216966 1.255603509721252 0.2092597582517403 1.0 0.4359498923615 25 Q9NR77,Q99720,P26358 3 +Beaking of vertebral bodies 0.5668564461413126 1.2533707710126931 0.2100708036293526 1.0 0.437440431397428 9 Q9Y2D4,P08236,P16278,Q7RTS9,Q6NUQ1 5 +Abnormality of corneal stroma 0.5464154892929812 1.2513724088611646 0.2107986388243738 1.0 0.438563416193429 10 P10619,P16278 2 +Cutaneous syndactyly of toes 0.4810463565430188 1.2513639338557063 0.2108017294353383 1.0 0.438563416193429 3 Q9H4L7 1 +Fasciculations 0.3931088248951995 1.2497419213221246 0.2113938382098312 1.0 0.4393958208385094 35 O95831,P07602,P49773,Q9NZJ7,Q9Y6X9 5 +Abnormality of the fetal cardiovascular system 0.5292081443590586 1.2494058539494075 0.211516668402431 1.0 0.4394515620871206 4 P47985,P16435 2 +Pathologic fracture 0.4862105018988196 1.247809894065987 0.2121006844943818 1.0 0.4402652303540977 15 Q14108 1 +Abnormal vertebral morphology 0.3097008647375485 1.2437481267618469 0.2135922772773719 1.0 0.4423610035395589 107 P15586,O96028,Q14108,Q15125,Q7RTS9,P35250,O95831,Q9Y6K9,O00170,P00813,Q14807,Q9BV10,O75718,P08236,P10619,Q8NCH0,Q9UHX1,Q01968,Q13045,Q8IWS0,Q9H9E3,P16278,Q14739,Q9Y619,Q9UIG0,Q10713,Q6DKJ4 27 +Stillbirth 0.5239610831570714 1.2429618120390389 0.2138819060459054 1.0 0.4423610035395589 11 P21333,O75369,Q8TD19,Q14739,Q53EZ4,O75844 6 +Talipes equinovarus 0.314603762140308 1.2428461038586525 0.2139245495458799 1.0 0.4423610035395589 79 O96028,Q9Y2D4,P52788,Q9NR77,Q15125,Q7RTS9,P21333,Q92890,P42356,P98175,Q9UPW6,Q15392,O75530,P06753,Q9Y5S9,Q9BV10,P32929,Q01082,P11047,Q9Y487,Q8TD19,P08236,Q9H2M9,Q8NCH0,Q15022,P50542,P61978,O75369,Q92766,P28482,Q9Y619,Q6NUQ1,Q9H9E3,Q53EZ4 34 +Thyroiditis 0.6020003147336355 1.242695195148681 0.2139801751882419 1.0 0.4423610035395589 7 Q05655,P00813 2 +Carcinoma 0.5724535835214969 1.2398134167284718 0.2150444145386758 1.0 0.4437593712098824 5 Q07864,P28340 2 +Joint subluxation 0.6181852797975009 1.2372855843719128 0.215981077759944 1.0 0.4454913893227867 6 Q9UHX1,P16278 2 +Abnormal nipple morphology 0.3409278903072399 1.23004493603654 0.2186802780812278 1.0 0.4499423565014755 60 O96028,Q9Y6K9,Q9BZH6,Q7LGA3,O75530,Q15067,Q96KP1,Q5SRE5,Q9UGU0,P10586,Q9BV10 11 +Hypermethioninemia 0.569633158429926 1.2262772937836424 0.2200943430237631 1.0 0.4523371991958388 5 P55263 1 +Fibrous tissue neoplasm 0.4626706294422049 1.2246261705875516 0.2207161027902366 1.0 0.452809324281001 18 P49815,Q05655,P49327,Q15392,Q13126 5 +Chronic pulmonary obstruction 0.5976931186529747 1.222623375163546 0.2214719801448872 1.0 0.4541564754135971 7 P06280,P09601,Q92766 3 +Abnormality of the nasal tip 0.3131002774607472 1.2201569453983745 0.2224053847385745 1.0 0.4554583650776087 97 O95831,Q9Y4W2,O43924,Q9UPW6,Q7LGA3,Q8ND04,Q9Y487,P42892,Q9H7D7,Q96KP1,P16278,Q9UHX1,O60828,Q9UGU0,Q8N201,P10586,Q6DKJ4,O75844 18 +Cervical ribs 0.4748796754304845 1.2167110259440532 0.2237141824817894 1.0 0.4575244920550269 3 Q9UHX1 1 +Parkinsonism 0.4088930836579221 1.2125509459400143 0.2253015533092326 1.0 0.4603269111832229 29 O75569,Q99720,P07602,P31930,P05067,Q15043 6 +Cavum septum pellucidum 0.4863808827286832 1.212478930406263 0.2253291030810231 1.0 0.4603269111832229 14 Q69YQ0,Q8ND04,Q9BV10 3 +Progressive leukoencephalopathy 0.4739287276499521 1.211367374831822 0.22575463737396 1.0 0.4606682903524811 3 Q9Y263 1 +Bifid scrotum 0.6123260437375795 1.211007966442341 0.225892351526733 1.0 0.460743891683537 6 Q01082,Q96EK5,Q9UBM7,O60566,Q69YQ0 5 +Decreased circulating level of specific antibody 0.5771805828216987 1.2104617609713204 0.2261017553221669 1.0 0.4607603446614238 8 Q05655,P49327,P00813,Q9BV10 4 +Pulmonary infiltrates 0.5765327918622045 1.207318447031152 0.227309529126459 1.0 0.4626036971150748 8 P49815,Q05655,Q9NZ08 3 +Radial bowing 0.5204708274961669 1.2043471693313206 0.2284554224132775 1.0 0.4636820270902521 4 P21333 1 +Decreased circulating total igm 0.5567283979314038 1.202067701205375 0.2293372989761155 1.0 0.464870158287724 9 Q05655,Q9Y6K9,P00813 3 +Asthma 0.4442707418728932 1.2008632989395598 0.2298042328631451 1.0 0.4655070848235482 20 Q92890,P50542,P00813,Q92766,Q08J23,Q93009 6 +Moderate global developmental delay 0.5368637041965634 1.200732637945963 0.2298549293644787 1.0 0.4655070848235482 10 O95831 1 +Nocturnal seizures 0.4252150893448175 1.1981311309518867 0.2308659711181406 1.0 0.4669348430436278 2 Q01082 1 +Spondyloepiphyseal dysplasia 0.4248841826605009 1.196091017607586 0.2316610425059453 1.0 0.4681180187075792 2 P27635 1 +Aortic valve stenosis 0.574167752372535 1.195843093643128 0.2317577955847443 1.0 0.4681180187075792 8 P16278,O75844 2 +Thickened skin 0.310972879604127 1.193983008441918 0.2324846147329009 1.0 0.4693789508744982 98 Q15125,O15269,Q9Y6K9,O00170,P06280,P00813,P50336,Q15800,Q9H267,P09493,Q9H4L7,P48449,Q9BZH6,P31751,P09884,Q9H488,O75844,P28340,P07437,P50542,Q06136,P98194,P16278,P53634,Q14739 25 +Breech presentation 0.5737088472638595 1.193616595584007 0.2326279792404395 1.0 0.469461314366619 8 P06753,Q9Y619,O75718 3 +Positive romberg sign 0.554299213433654 1.1897648774742298 0.2341388177670436 1.0 0.4718025748564217 9 Q8IV08 1 +Omphalocele 0.4826174439831645 1.1895385959149107 0.2342277925580496 1.0 0.4718025748564217 14 P43034,O15111,Q14739,Q6DKJ4,Q69YQ0 5 +Hemorrhage of the eye 0.4930799438064356 1.1895280996495985 0.2342319203117631 1.0 0.4718025748564217 12 Q9Y487,Q9Y6K9,O15484,Q92947 4 +Abnormal circulating fatty acid anion concentration 0.4879782054587411 1.189238871241118 0.2343456823437328 1.0 0.4718025748564217 13 P09622,O43772 2 +Abnormal shape of the frontal region 0.3083841097973549 1.1883292991617984 0.2347036988554283 1.0 0.4721928921588111 103 P15586,O96028,Q15125,Q8N201,Q6PGP7,Q9Y6K9,O00170,Q9UPW6,Q15392,P55263,Q00839,O43924,Q8ND04,Q86XI2,P50542,Q15067,P16278,Q14739,Q9Y619,Q9UGU0,Q6DKJ4,Q69YQ0 22 +Neonatal hyperbilirubinemia 0.4694189159765531 1.186028100149116 0.2356112025898293 1.0 0.4734025122163655 3 P36551 1 +Cupped ear 0.4920034947483451 1.1832214953732627 0.2367213760926789 1.0 0.4749994468988126 12 Q15392,P42892 2 +Emphysema 0.5526604844948945 1.1814663969208694 0.2374174948871568 1.0 0.4753268277061356 9 P49815,Q05655 2 +Lymphedema 0.4693544520817834 1.1808324918015063 0.2376692736906789 1.0 0.4753268277061356 16 P49815,Q9Y6K9,P26358,P06280,P08236,P60953,Q14739,Q00535 8 +Dysphagia 0.2915659324974316 1.1807165631051544 0.2377153394405384 1.0 0.4753268277061356 124 P00846,P15586,P07737,O75569,Q86XI2,Q14108,Q9NZJ7,Q9NR77,Q99720,P06753,P07602,Q15067,O60220,Q14739,P61916,P05067,O15118,Q69YQ0 18 +Dyschromatopsia 0.5886285147375256 1.1803881320968843 0.2378458799403229 1.0 0.475380171391641 7 Q9H061 1 +Restlessness 0.3782122438984515 1.1798657730430706 0.2380536047209986 1.0 0.4755876686198215 40 P48449,P07737,Q9UPW6,Q15165,P42892,Q6PJG6,P05067 7 +Abnormality of lower limb epiphysis morphology 0.4689803393047544 1.178453619478746 0.2386158122519561 1.0 0.4761063238599556 16 Q7LGA3,O95831,Q7RTS9 3 +T cell lymphoma 0.5595091043756975 1.177695716471203 0.2389179352201786 1.0 0.4761063238599556 5 Q05655,P49327,Q07864 3 +Distal sensory impairment 0.3721322159444976 1.177361843441488 0.2390511126643195 1.0 0.4761257365816321 43 P49773,Q9NR77 2 +Respiratory distress 0.3474163732548901 1.1748397562459414 0.2400588313148359 1.0 0.4777170743165236 52 P49815,P00846,O95831,Q9Y619,P07602,P51970,Q9NZJ7 7 +Localized skin lesion 0.2676944641112727 1.1687844384774202 0.2424904916211137 1.0 0.4810918856306187 206 Q03164,O96028,P43034,Q15125,O15269,Q9H9Y6,Q9NYB0,Q9NZJ7,Q92542,Q13126,Q6PGP7,P35250,P49815,P21333,Q9Y6K9,O00170,Q9UPW6,P06280,Q7LGA3,P61586,Q15392,O75530,Q8IZA0,P07602,P36551,Q08J23,Q00839,Q9H4L7,Q05655,Q9NZ08,O15111,Q8NCH0,Q9UHX1,Q9H488,O75844,Q6P2Q9,P49327,Q01968,Q86XI2,P28340,Q06136,Q92766,Q9UIG0,P53634,Q14739,Q9Y619,Q9UGU0,Q6DKJ4,Q69YQ0 49 +Central diabetes insipidus 0.4202514890800888 1.1675345375134534 0.2429945690952197 1.0 0.4815552236743774 2 P35222 1 +Freckling 0.5304039740210588 1.1664971143577283 0.2434135146108551 1.0 0.4818787441063512 10 P11802,Q9NYB0,P10644,Q06124,Q9H488,P62140,P52701 7 +Irregular epiphyses 0.5569777805712434 1.165553129594799 0.2437951674484235 1.0 0.4820863500095138 5 Q7RTS9,P50542 2 +Pelvic girdle muscle weakness 0.5853800155880572 1.1652574437802714 0.243914799567634 1.0 0.4820863500095138 7 Q14315,A6NHR9,P06753,O14979,P55072 5 +Abnormality of the distal phalanx of the thumb 0.4657102474013709 1.165195922988752 0.2439396955695945 1.0 0.4820863500095138 3 P21333 1 +Tissue ischemia 0.4216304361482095 1.1643548864951463 0.2442802220317883 1.0 0.4825509608284399 23 P49327,Q9Y6K9,Q9UIG0,Q9NZ08,P35250,P05067,O75844 7 +Restrictive ventilatory defect 0.488581201762757 1.163175346050204 0.2447583671271131 1.0 0.4830683621977497 12 P49815,P16278 2 +Abnormal nephron morphology 0.3348582859373873 1.1625071546069352 0.245029520196029 1.0 0.4830683621977497 61 P00846,Q05655,P00403,P49327,Q01968,P11047,P06280,Q14108,Q92621,P00813,Q9NPF4,Q8NFH4,Q9UIG0,Q9NZ08,Q8N1F7,Q9BU61,Q14C86,P35250 18 +Antinuclear antibody positivity 0.5562136247755587 1.161888048344632 0.245280942483629 1.0 0.4830683621977497 5 Q05655,P49327 2 +Choanal stenosis 0.5119305326956738 1.1603186769892977 0.2459190830491608 1.0 0.4837007490829434 4 Q9H9Y6 1 +Abnormal blood sodium concentration 0.5077780261269254 1.1529250516715872 0.2489411485358195 1.0 0.4881763654020761 11 P36551,Q01968,Q13423,Q9BV10 4 +Abnormal uvula morphology 0.3731225340407239 1.148766839235578 0.2506521365077878 1.0 0.4911107999983496 41 Q01082,P21333,P62140,Q9UPW6,P61978,P34897,P46777,P52788,Q15392,P38398,A6NHR9,P78318,P62266,P09884,Q9Y619,Q6PGP7,Q6DKJ4,Q69YQ0 18 +Poor appetite 0.4860695659777936 1.1484683372431974 0.2507752767730937 1.0 0.4911418236159393 12 Q70HW3 1 +Hypoparathyroidism 0.5066516028885146 1.1466625469385805 0.2515211152704659 1.0 0.4916694767950963 11 P40939,P00403,Q08J23 3 +Abnormality of bone mineral density 0.2880878637352194 1.146515775784821 0.251581803507563 1.0 0.4916694767950963 131 O95831,O96028,Q9HC07,O00170,Q9BZH6,O75531,Q14108,Q15392,O75530,Q15125,P07602,P16278,Q14739,Q9NZJ7,Q13126,Q15043,O75844 17 +Abnormal rib cage morphology 0.3278505602936767 1.1436944489640195 0.2527503763009866 1.0 0.4927827968231799 70 P15586,Q9Y6K9,O95831,O75531,P00813,P16278,Q6DKJ4,Q7RTS9,Q14739,Q9Y619,O75844,Q9BV10 12 +Cyanosis 0.4750544346743363 1.143460668243088 0.2528473759555956 1.0 0.4927827968231799 14 O43772,O75844 2 +Abnormal coronary artery morphology 0.5969016599700322 1.1418651155908244 0.2535100908559471 1.0 0.4933836619036089 6 P16278,P34913 2 +Abnormality of the humerus 0.4632140654272795 1.1418006407722578 0.2535368959574586 1.0 0.4933836619036089 16 O00116,Q7RTS9,Q9BV10 3 +Focal segmental glomerulosclerosis 0.435569003422009 1.140009661704843 0.2542822759309961 1.0 0.4942038118624923 20 P00403,Q14108,Q92621,Q8NFH4,Q8N1F7,Q14C86 6 +Abnormal cervical spine morphology 0.5072066043401513 1.1359803221772062 0.2559647998851959 1.0 0.4964198682519244 4 O75369,Q8NCH0 2 +Dystrophic toenail 0.5788456300876503 1.1348362912931025 0.2564439173611197 1.0 0.4971384200600783 7 O75844 1 +Constitutional symptom 0.2561973885117538 1.1340371124010875 0.2567789808910188 1.0 0.497577220803638 229 P26358,Q14108,Q9NR77,O43681,O15269,Q9NZJ7,Q15043,Q70HW3,P49815,P07737,P14174,Q15165,P06753,P07602,Q15800,O75569,Q14566,P42892,O95425,Q99720,Q9NZ08,P40939,O75844,Q9Y6X9,P00846,Q8NFH4,Q13423,Q14739 28 +Patellar aplasia 0.5067755949771087 1.1337604617692396 0.2568950401451144 1.0 0.4975914510131988 4 Q9Y619 1 +Abnormal preputium morphology 0.5781958873923927 1.131812685822683 0.2577131932113679 1.0 0.4986476580868596 7 P38398,O60828 2 +Paralysis 0.3629996991278644 1.131680745440901 0.2577686793647369 1.0 0.4986476580868596 45 P07737,P60174,P10253,Q15233,P31040,Q9NR77,Q15165,P54136,P55072,Q92804,P50336,P36551,P09884,Q8WXH0,Q9Y6X9 15 +Heparan sulfate excretion in urine 0.5063221717485166 1.1314253157898768 0.2578761211910851 1.0 0.4986476580868596 4 P15586 1 +Aplasia hypoplasia of the scapulae 0.5060688356699001 1.1301206962764117 0.2584253700249994 1.0 0.4994986987349756 4 Q7RTS9 1 +Weak voice 0.5494931077781418 1.1296680919184752 0.2586161071823238 1.0 0.4995710240284375 5 P04062,P43243 2 +Aplasia hypoplasia affecting bones of the axial skeleton 0.2561444801816424 1.1294124751859829 0.258723872643078 1.0 0.4995710240284375 230 Q03164,O96028,P46777,Q15125,Q9NPF4,Q7RTS9,Q9H9Y6,P35250,Q8N201,Q00535,Q07020,Q13057,O95831,P98175,Q9UPW6,Q9BUB7,Q7LGA3,Q15392,O75530,P06753,Q08J23,Q9BTW9,Q00839,Q9BV10,Q9BUK6,O43924,Q8ND04,P08236,O15111,O60828,Q8NCH0,Q9UHX1,O75844,Q86XL3,Q9Y4W2,Q01968,Q86XI2,O75531,P50542,P28340,P61313,Q9H7D7,Q92766,Q9UIG0,Q13045,Q9H9E3,P16278,Q6PJG6,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 54 +Irritability 0.3236321145806304 1.1292551061428324 0.258790233334373 1.0 0.4995710240284375 74 P00846,O95831,P26358,Q8IYI6,Q5KU26,Q8NFH4,O43772,P50897,Q9NZ08,P07602,Q15067 11 +Hip contracture 0.5034135105235308 1.12866561994239 0.259038917632111 1.0 0.4996296359048345 11 Q7LGA3 1 +Abnormality of the achilles tendon 0.477684378076888 1.1277826383425933 0.2594117273596055 1.0 0.5001379427653388 13 P49773 1 +Muscle fibrillation 0.4545722509270708 1.1266877675785312 0.259874516102482 1.0 0.500608442845564 17 P49773 1 +Autoimmune antibody positivity 0.5027181197264243 1.124801946290419 0.2606729695348861 1.0 0.5015725288840738 11 Q05655,P00813 2 +Humeroradial synostosis 0.4133024487094708 1.1247293367739537 0.2607037461689341 1.0 0.5015725288840738 2 P16435 1 +Elbow ankylosis 0.4133024487094708 1.1247293367739537 0.2607037461689341 1.0 0.5015725288840738 2 P16435 1 +Abnormality of glycolipid metabolism 0.5582969602570397 1.1188938237674764 0.2631854381649079 1.0 0.5052851302352279 8 P06280,P07602,O43681,Q9NZJ7 4 +Abnormality of salivation 0.3715725310369323 1.1176098157095624 0.2637336747170236 1.0 0.5059132561524798 40 P07737,P15586,Q9NR77,Q15165,Q14739 5 +Tetraparesis 0.3729157024778001 1.1151401819764892 0.2647903547983095 1.0 0.5073024085022447 39 P00846,P07602,Q7RTS9,P49773,Q9UBX3 5 +Abnormal circulating carbohydrate concentration 0.3779817996450893 1.114585342054448 0.2650281545178337 1.0 0.5073913321877228 35 Q9Y6M9,O95831,Q86Y39,Q9BWD1,Q5JRX3,P22695,O75251,Q96CU9,Q70HW3 9 +Osteolysis 0.3972789967711118 1.114038386839796 0.2652627189019469 1.0 0.5073913321877228 28 Q14108,Q9Y6K9,O75531,O75844 4 +Episodic tachypnea 0.5739238571198955 1.1119397887931268 0.2661640396093268 1.0 0.5080813223004079 7 Q10713,O43924 2 +Abnormality of coordination 0.2580464726813202 1.1118655046342665 0.2661959822758091 1.0 0.5080813223004079 304 O96028,P00403,P26358,Q14108,Q9NR77,P35270,O43681,Q7RTS9,Q9UHD1,P49773,O95831,Q9Y4I1,Q9BUB7,O75530,Q5JRX3,P06753,P07602,P09622,P41440,P05067,O15118,Q9BZH6,O43924,Q86Y39,P11182,Q99720,Q9NZ08,P50897,P40939,P61916,P00846,Q8IV08,P50542,Q15067,P16278,Q6PJG6,Q9Y619,Q9UGU0,Q10713 39 +Central hypoventilation 0.5898620563948258 1.1103445552729194 0.2668505803858554 1.0 0.5085526397708194 6 P06753 1 +Bilateral external ear deformity 0.455809334657401 1.1096286401324884 0.2671590844970808 1.0 0.5085859832765456 3 P14923,O94905 2 +Cerebral inclusion bodies 0.4637599937257615 1.108146363367838 0.267798610615297 1.0 0.5090175418547401 15 P05067,O15118 2 +Falls 0.5445582654468452 1.106028628358102 0.2687141283473786 1.0 0.5101216166621524 5 Q8WVX9,Q01082,P21912 3 +Ankyloglossia 0.5723113578669545 1.104442251511662 0.269401341124702 1.0 0.5105796846077687 7 O75844 1 +Hypoplasia of the iris 0.5438856928829132 1.1028083572502938 0.2701103980601396 1.0 0.5114999139103263 5 Q7LGA3,O96028 2 +Abnormally large globe 0.5877932476133217 1.101087753022488 0.2708584666855991 1.0 0.5127043846236505 6 Q9H7D7,Q86XI2 2 +Aplasia hypoplasia of the capital femoral epiphysis 0.543204146167136 1.0995455381121946 0.2715301824111236 1.0 0.5134632730330064 5 Q7LGA3,Q7RTS9 2 +Convex nasal ridge 0.4126004889560432 1.097015977300564 0.2726344078030729 1.0 0.5143437761329078 23 O96028,P28340,Q9UPW6,O75531,Q5SRE5,O75844 6 +Wide intermamillary distance 0.4125693185393932 1.096783765809901 0.2727359284847208 1.0 0.5143437761329078 23 Q9BZH6,P07437,P61978,O75530,P52788,Q96KP1,Q5SRE5,Q06124,Q9UBM7,P62140 10 +Abnormal greater sciatic notch morphology 0.5422074038667829 1.0947745468858807 0.2736154201011156 1.0 0.5157898590621113 5 Q7RTS9,P08236 2 +Lower limb muscle weakness 0.3688341315892388 1.0919744742515485 0.2748443209593796 1.0 0.5174749699929181 40 P00846,Q9NR77,P06753,P40939,P49773 5 +Bifid uvula 0.3743814768326801 1.091964933259512 0.2748485147591837 1.0 0.5174749699929181 36 P21333,P62140,Q9UPW6,P61978,P34897,P46777,P52788,Q15392,P78318,P62266,P09884,Q9Y619,Q6PGP7,Q69YQ0 14 +Xerostomia 0.4715400547132182 1.091150105960765 0.2752068381592458 1.0 0.5175109688803896 13 P07737,Q15165,P55072,Q92804,Q14739 5 +Exaggerated cupid s bow 0.5693753903766958 1.090796791344921 0.2753623086647665 1.0 0.5175906721801381 7 Q96KP1,Q6DKJ4 2 +Premature graying of hair 0.533826846588289 1.0862086140662432 0.2773867070865243 1.0 0.5199033824383459 9 Q13126 1 +Spinal cord compression 0.407015221707489 1.0860505759759522 0.2774566168963828 1.0 0.5199033824383459 2 O75369 1 +Advanced ossification of carpal bones 0.4070152217074884 1.0860505759759482 0.2774566168963845 1.0 0.5199033824383459 2 Q9BYW2 1 +Exercise intolerance 0.3881677912281103 1.0856926297256535 0.2776150025517407 1.0 0.5199033824383459 30 P00403,P06753,P40939,P49773,Q9H2D1 5 +Perseveration 0.5841345223558446 1.0847255496747927 0.2780432283167344 1.0 0.5204923746444554 6 P61916,Q93009,P55072 3 +Eruption failure 0.5835864925758064 1.0822757281153406 0.2791300277342912 1.0 0.5218864938479783 6 P21333,O75844,A6NHR9 3 +Shoulder girdle muscle weakness 0.5329389654278803 1.081725646058718 0.2793744539206462 1.0 0.5221302064494886 9 P43243,P55072,P06753,P07602,O14979,Q9NZJ7 6 +Spastic paraparetic gait 0.4502505720922432 1.0784776987255045 0.2808206288864265 1.0 0.5241908721097774 3 Q15043 1 +Narrow mouth 0.3246858272575396 1.077862300140159 0.2810952118746255 1.0 0.5244800794082908 67 P43034,P52788,Q9NPF4,Q9H9Y6,Q6PGP7,Q92890,P21333,Q9UPW6,Q15233,Q7LGA3,Q15392,Q9Y487,Q8NCH0,O60828,O75844,P28340,P07437,Q92766,Q9Y619,Q9UGU0 20 +Young adult onset 0.5136081285590208 1.0776169285562542 0.2812047443451924 1.0 0.5244800794082908 10 P07602,Q9NZJ7,Q14566,O15118 4 +Pulmonary edema 0.4495200264812985 1.074387048754128 0.2826492447190243 1.0 0.526744948322058 3 Q14315,O95235 2 +Sparse eyebrow 0.37432607115432 1.073843911971884 0.2828926451146294 1.0 0.5269839791166702 34 P48449,O75531,Q9H7D7,P52788,Q15125,P60953,Q08J23,Q5SRE5,O60828,P62304,P62140,Q9BTW9,O75844 13 +Memory impairment 0.3730431831077299 1.0705723094806554 0.2843617797162907 1.0 0.529289900675666 35 P00403,P26358,Q9NZ08,P07602,O43681,P05067 6 +Abnormal visual electrophysiology 0.3461482394640386 1.0643844712994817 0.2871545655235605 1.0 0.5330924061386111 49 P00846,O43924,P50897,Q15067,P07602,O43681,O60220,P40939,O75503,Q9NZJ7 10 +Abnormal pleura morphology 0.4081634460908873 1.063982874848438 0.2873364574926706 1.0 0.5330924061386111 23 P49815,P14174,P08236,Q9NZ08,Q14739,Q8NCH0 6 +Apnea 0.2979858839952582 1.0628780330505931 0.2878372660581085 1.0 0.5335889699262709 80 P00846,O00170,P98175,O43924,Q86Y39,P50542,O43772,P07602,Q96KP1,Q6PJG6,Q9NZJ7,Q10713 12 +Tongue fasciculations 0.4913383640722109 1.0616558024717246 0.2883919707939792 1.0 0.5343807007760502 11 O95831,Q9BTW9,P55072 3 +Abnormal gallbladder morphology 0.3742509144959762 1.0606773637339608 0.2888365505957568 1.0 0.5347916230084059 32 Q92766,Q9UIG0,P07602,O43681,P22830,Q9NZJ7,Q69YQ0 7 +Somatic sensory dysfunction 0.2993564285538365 1.0581861188795412 0.2899705984442384 1.0 0.5360240020514052 104 P00846,O95831,Q8IV08,Q9NR77,Q9NZ08,P07602,O15269,P41440,Q9Y619,P49773,Q9NZJ7,P05067,Q9Y6X9 13 +Ragged red muscle fibers 0.4307011009311783 1.0567102823682524 0.2906438308135364 1.0 0.5370516001750327 19 P00846,O95831,Q70HW3,Q9H2D1 4 +Bradycardia 0.4600253935371306 1.0520862120229932 0.2927599974453816 1.0 0.5403132433415 14 Q6PJG6,O43772 2 +Abnormal muscle fiber morphology 0.3243098187634998 1.0520793849002794 0.292763129448748 1.0 0.5403132433415 64 P00846,O95831,Q99720,Q9H2D1,P05067,Q70HW3 6 +Abnormality of globe size 0.3248755906553612 1.048785413237593 0.2942768924590702 1.0 0.5424508001551205 62 Q9Y6K9,O75569,Q86XI2,O43924,P61586,Q9H7D7,Q15125,Q9NPF4,Q92766,Q9UHX1,Q5SRE5,O15111,O60828,Q8N201,Q9BUK6 15 +Inflammatory abnormality of the eye 0.36519693542421 1.043711049199376 0.2966190962393984 1.0 0.5451772244119621 39 P04439,Q9Y6K9,O15484,P14174,Q05655,Q9NZ08,Q15800,Q14739 8 +Synostosis involving bones of the hand 0.4878004644003959 1.0420633071303032 0.2973823289742656 1.0 0.5459763015303706 11 P21333,Q15233,Q9Y5S9,O60828,Q6DKJ4 5 +Absent thumbnail 0.3994043679682428 1.0393232422145051 0.2986544289249027 1.0 0.5472142999156508 2 Q9H936 1 +Large fleshy ears 0.3994043679682415 1.0393232422144976 0.2986544289249062 1.0 0.5472142999156508 2 O43776 1 +Capillary hemangioma 0.5739018044232618 1.0390345959368512 0.2987886467741374 1.0 0.5472411509744806 6 Q7LGA3,Q9UHX1 2 +Decreased circulating androgen concentration 0.5414370688561787 1.037374532817294 0.2995613423906751 1.0 0.548436905648848 8 Q9BZH6 1 +Abnormal delivery 0.4134050076211653 1.036603789805416 0.2999205463607646 1.0 0.5488749862827746 21 O75718,Q9Y487,P06753,Q9Y619,Q9UBM7,O75844 6 +Bruising susceptibility 0.387152153461244 1.032197439153933 0.3019796344683219 1.0 0.5524223768830973 28 Q05655,P49327,O00170,P49257,Q14108,P35579,Q8NCH0,Q13126 8 +Abnormality of the pubic bone 0.5566187757351261 1.0316148287657103 0.3022525908992515 1.0 0.5527008024554032 7 Q8IZA0,O96028,Q7RTS9 3 +Color vision defect 0.4395217291163057 1.0291155165503143 0.3034253955868484 1.0 0.5546238161345868 17 Q9BZH6,O60220,Q709C8,Q99497,Q9H061,Q9H6K4,Q9Y6X9 7 +Genu valgum 0.3705183158848698 1.0283334889912312 0.303792983158053 1.0 0.5550740454748139 32 Q01968,Q7LGA3,Q14807,Q9NR77,P08236,Q9UIG0,P16278,Q7RTS9,Q9Y619,P35250 10 +Abnormality of earlobe 0.3867734964577016 1.027347342700776 0.3042569371539878 1.0 0.5556925402389735 27 P98175,Q7LGA3,Q15392,Q92766,Q8IWS0,P10586 6 +Hypotension 0.3867423275374038 1.0270980305467348 0.3043743059600408 1.0 0.5556925402389735 27 Q13423,O43772,P07602,O43681,Q9NZJ7 5 +Decreased circulating igg level 0.4846923302219789 1.0248700458503688 0.3054245100200878 1.0 0.5570172937162567 11 Q05655,P49327,P00813 3 +Alopecia of scalp 0.5382201266066217 1.0218621611308758 0.3068461436514891 1.0 0.5588678071997079 8 P61586 1 +Upper limb spasticity 0.554428535553813 1.0214747975740726 0.307029543563873 1.0 0.5589794036960409 7 Q9BTW9,Q8NI27,Q99720 3 +Abnormal autonomic nervous system physiology 0.3681685257720369 1.0195755181338562 0.3079298207548817 1.0 0.5601728098549656 34 P06280,P15289,P42892,Q15067,P07602,O43681,P50336,Q709C8,Q6PJG6,P41440,Q9NZJ7 11 +Gynecomastia 0.443165442783318 1.0147290223860383 0.3102350156552469 1.0 0.5633700436223023 16 Q9Y4W2,O00170,Q9BZH6,P31751 4 +Vasculitis 0.5196156321754481 1.0145868879764095 0.3103027922158234 1.0 0.5633700436223023 9 Q9NZ08,Q05655,P49327 3 +Severe combined immunodeficiency 0.552754631141974 1.0137301184726462 0.3107115483947416 1.0 0.5635857855234613 7 P00813 1 +Combined immunodeficiency 0.5364189053489122 1.0131838253968295 0.3109723647999136 1.0 0.56369129255018 8 P00813 1 +Abnormal talus morphology 0.4242261352640014 1.0127773563339757 0.3111665187941199 1.0 0.5638199352813488 19 P98175,Q5SRE5,O75844 3 +Sinus tachycardia 0.5190900662430045 1.0119444050978448 0.3115646360091564 1.0 0.5640946752428437 9 P06753,O75531 2 +Short ribs 0.500901691916413 1.0106168736780088 0.312199836577375 1.0 0.5647494262860465 10 Q9Y619,P21333,Q14739,Q9BV10 4 +Peripheral axonal degeneration 0.3171762965429873 1.0104151378937087 0.3122964382630508 1.0 0.5647494262860465 70 P00846,O95831,P00403,Q8IV08,Q15067,P07602,O15269,P41440,P49773,Q9Y6X9 10 +Abnormality of hair pigmentation 0.4052520062772838 1.0087723394377652 0.3130838295659712 1.0 0.5659497187691352 22 P49327,Q9Y4I1,O14617,Q6PGP7,Q13126 5 +Recurrent respiratory infections 0.2832210702109727 1.0050620558011003 0.3148669695737587 1.0 0.5680512888210854 122 P15586,O96028,P09601,O95298,Q7RTS9,Q9NZJ7,P35250,P49815,P21333,P14174,Q9Y4I1,P00813,P78318,P06753,P07602,Q9BTW9,Q9BV10,Q05655,P11047,Q9Y487,O14617,P78527,P08236,P09884,Q01968,P50542,P53634,P16278,Q9H9E3,Q9UIG0,Q6DKJ4 31 +Abnormality of skin physiology 0.2989549500488012 1.0030938651119856 0.3158155744378952 1.0 0.5693138575038386 95 P48449,Q9Y6K9,P10321,P14174,P00813,Q8ND04,Q15125,Q9NZ08,P53634,Q08J23,Q14739,Q15800,P22830,Q92542,Q9Y6X9 15 +Respiratory arrest 0.5340551378444469 1.0018036502310232 0.3164384339241959 1.0 0.56976345872189 8 Q9H0U9,P13473,O43772 3 +Retinal pigment epithelial atrophy 0.4807947019867401 1.0003561942760342 0.3171381613887116 1.0 0.570798806400367 4 P51648,P50213,Q8TC12 3 +Happy demeanor 0.5222134021784087 0.9993317745359692 0.3176339979082967 1.0 0.5712419679474554 5 Q9UPW6 1 +Fatigue 0.3007227305224615 0.999007736102476 0.3177909437326562 1.0 0.571299744487183 78 P49815,P07737,Q15165,Q13423,O95425,Q9NZ08,P07602,P06753,Q14739,Q9NZJ7,Q70HW3,Q9Y6X9 12 +Perisylvian polymicrogyria 0.5219220390163115 0.997945513527834 0.3183057803603444 1.0 0.5713054444841087 5 P34897 1 +Axonal degeneration regeneration 0.4356173452499127 0.9967322516195372 0.3188944905514712 1.0 0.571862229998368 3 P02545,O95140 2 +Intellectual disability progressive 0.4556228667587748 0.996559382274626 0.3189784297980846 1.0 0.571862229998368 13 O95831 1 +Progressive spasticity 0.4401762247730154 0.9958598649286926 0.3193182383687305 1.0 0.5720403073828146 16 P43034,P07602,O43681,Q9NZJ7,Q9BTW9 5 +Hemiparesis 0.4552905544158739 0.9945908512522252 0.3199352989062685 1.0 0.5723477133016658 13 P49815,Q9NZ08,P49327,P00403 4 +Schistocytosis 0.4343438000862631 0.9896407985355844 0.3223497209827635 1.0 0.5749784384014452 3 P41440 1 +Fatigable weakness of bulbar muscles 0.4539797971358325 0.9868293042139012 0.3237263262405032 1.0 0.5767595933058713 13 P07737,Q15165,P55072,Q92804,P06753 5 +Hemivertebrae 0.4533291850855784 0.9829785966598522 0.325617972798929 1.0 0.5794531343315311 13 Q9Y619,Q9Y6K9,Q15125 3 +Advanced eruption of teeth 0.4769256197003076 0.9819992249130108 0.3261002300595996 1.0 0.5798895071208019 11 Q69YQ0,Q9UBM7,O75844 3 +Corneal opacity 0.3353585229526955 0.9807468410764694 0.3267175986355495 1.0 0.5798895071208019 50 O96028,Q9Y6K9,Q01968,O75569,Q86XI2,P50542,Q06136,P08236,Q9UIG0,P10619,P16278,O15111,P09884,P35250,Q9UBM7,O75844 16 +Abnormal renal vascular morphology 0.3898080741231062 0.9806139174427146 0.3267831685143068 1.0 0.5798895071208019 2 P21912 1 +Abnormal epiphyseal ossification 0.419420721467009 0.9802551820521418 0.3269601717011332 1.0 0.5798895071208019 19 P50542,Q14807,Q15125,P08236,O00116,Q7RTS9,Q14739 7 +Pulmonary fibrosis 0.4126228617391859 0.9801674763201 0.3270034559490473 1.0 0.5798895071208019 20 Q05655,P49327,P14174,Q6NZY4,Q8IZA0,P09601,Q86TI2 7 +Aplasia hypoplasia involving the pelvis 0.4375354316856982 0.9792127549181436 0.3274748676711319 1.0 0.5802758301706429 16 O95831,P50542 2 +Skin nodule 0.4122646973031914 0.977684684710156 0.328230298794693 1.0 0.5809397051752939 20 P49815,P49327,Q01968,P06280,P34913,P11802,Q92990,Q9NZ08 8 +Aplasia hypoplasia of the humerus 0.4943923285325335 0.9764149156457692 0.3288588929410601 1.0 0.581827272126491 10 O15228,P21333,P50542,Q9Y5S9,O00116,Q9BV10 6 +B cell lymphoma 0.5171651905880337 0.9753364536554447 0.3293933937218312 1.0 0.5825477446154641 5 Q05655,P00813 2 +Large face 0.3137230193352903 0.9750020404561024 0.3295592478189872 1.0 0.5826159433246445 71 Q01968,O00170,Q9UPW6,O43924,Q7LGA3,Q96NT0,P52788,Q13045,Q92766,P06753,Q08J23,Q6PJG6,P09884,O60828,Q9UGU0,Q10713,Q9BUK6,Q9BV10 18 +Abnormal arterial physiology 0.3796147598546694 0.9739116347107004 0.330100416340382 1.0 0.5832037472917136 29 Q9NZ08,P05067,Q14739,O75844 4 +Abnormal c peptide level 0.4755644235308941 0.9736430541839924 0.3302338011520125 1.0 0.5832037472917136 4 P40939 1 +Absent septum pellucidum 0.363589446128205 0.9733056327129256 0.3304014237988668 1.0 0.5832037472917136 33 O96028,Q9BZH6,Q15392,Q08J23,Q96N66 5 +Mandibular aplasia 0.516592023896848 0.9726153266456922 0.3307445223317278 1.0 0.5833594137619723 5 Q9Y619 1 +Antineutrophil antibody positivity 0.4751195295895909 0.9713737852621352 0.3313621778407762 1.0 0.5841780483764596 4 Q05655 1 +Preaxial polydactyly 0.4512554037441791 0.9707132187400752 0.3316911074382813 1.0 0.5843534252290276 13 Q9UHX1,P21333,O96028,O43924 4 +Gait disturbance 0.2528415866271981 0.9700862813715304 0.3320034865194112 1.0 0.5844538299228251 299 P00403,Q14108,Q9NR77,O43681,O60220,O15269,Q7RTS9,P49773,Q9NZJ7,Q8N201,Q15043,O95831,Q9Y6K9,P98175,Q7LGA3,O75530,Q5JRX3,P06753,P07602,P41440,P05067,O15118,O75569,Q9BZH6,O43924,Q8ND04,Q99720,Q9NZ08,P40939,O75844,Q9Y6X9,P00846,Q8IV08,P50542,Q15067,P16278,Q6PJG6,Q9Y619,Q9UGU0,Q10713 40 +Urinary glycosaminoglycan excretion 0.5579535092078819 0.9681039864283016 0.3329924391783267 1.0 0.5855191679290057 6 P15586,P16278 2 +Dysostosis multiplex 0.5422041750083509 0.9650271054993138 0.3345312355631975 1.0 0.5871712001837487 7 P10619,P16278 2 +Sepsis 0.4102911335952482 0.9640131088131744 0.3350393537348317 1.0 0.587538360936523 20 P00813,P42892 2 +Hyporeflexia of lower limbs 0.47325822578706 0.96180886847109 0.336145622389385 1.0 0.5888015743116017 11 Q9NR77 1 +Osteomyelitis 0.4495118445179927 0.9604113875074612 0.3368482091423099 1.0 0.5897810809932749 13 Q13126,P26358 2 +Abnormal circulating ferritin concentration 0.5555618698781364 0.957504602071698 0.338312624677108 1.0 0.5912397415605664 6 P41440 1 +Abnormal vena cava morphology 0.5078670277840616 0.9556530613641264 0.3392475442347242 1.0 0.592647332046692 9 Q05655,Q8ND04,P98175,Q7LBC6 4 +Bilateral talipes equinovarus 0.5550518087149693 0.9552455429415404 0.3394535394831686 1.0 0.592723766172355 6 Q15392,Q15125 2 +Poor wound healing 0.5548287001927614 0.9542575604798876 0.3399532846625319 1.0 0.5932009850935602 6 O15269 1 +Orthostatic hypotension due to autonomic dysfunction 0.4898226771354012 0.952466202581138 0.3408605985028783 1.0 0.5943310321324472 10 P07602,O43681 2 +Aplasia hypoplasia of the tibia 0.4712792437224412 0.951806765258475 0.3411949903945881 1.0 0.5946875365712223 4 O75369,Q9BV10 2 +Abnormal circulating sulfur amino acid concentration 0.52351971084834 0.951215555414576 0.3414949635300117 1.0 0.5949838020848358 8 P55263,P41440 2 +Erythema 0.3882715762352671 0.95081388218119 0.341698864218634 1.0 0.5949881822695754 24 Q9Y6K9,P00403,Q15125,P22830 4 +Abnormal lung lobation 0.4431413798617291 0.9500078282397753 0.342108274961332 1.0 0.5951376453859638 14 Q92766,Q14739,O15111,Q9UBM7,Q9UHX1 5 +Adult onset 0.3158235878583468 0.9462723438618298 0.3440096955282352 1.0 0.5972244228649987 63 P49815,Q8IV08,P26358,Q14566,P07602,P31930,P41440,Q9Y4G8,Q9NZJ7,O15118 10 +Hyperreflexia 0.2469508054838791 0.945611476069184 0.3443467887132907 1.0 0.5972244228649987 221 O14949,P26358,Q9NR77,P35270,P42695,O43681,O60220,Q96F07,Q7RTS9,O75251,Q9UHD1,Q9NZJ7,P35250,Q15043,O95831,P15289,Q2TAA5,Q5KU26,Q5JRX3,P07602,P50336,O15382,Q709C8,Q08J23,Q96CU9,Q9BTW9,P20674,O15020,O75569,Q8IYI6,P34897,Q99720,Q96KR1,Q9NZ08,Q9BU61,Q99497,O60828,Q96N66,Q9H6K4,Q9Y6X9,P00846,Q86XL3,Q6P2Q9,P49327,Q01968,P50542,P08243,P23378,P54136,Q15067,Q9H9E3,Q6PJG6,O75503,Q14739,Q9Y619,Q9UIG0,Q10713 57 +Short foot 0.3764709370103497 0.9451692528479502 0.34457247410467 1.0 0.5973894749913162 27 Q08J23,Q13555,Q9Y4W2 3 +Abnormal circulating methionine concentration 0.5522284181063004 0.9427503906323854 0.3458085920988414 1.0 0.5986255393481079 6 P55263 1 +Morphological abnormality of the pyramidal tract 0.4137718482869048 0.942135042915606 0.3461235052875873 1.0 0.5987359820090195 19 P00846,O95831,O75569,Q9UIG0,Q9Y619,P35250 6 +Limited extraocular movements 0.5371684963378947 0.9418589996206757 0.3462648338164462 1.0 0.5987359820090195 7 Q9UHD1,Q9BU61 2 +Oligomenorrhea 0.550987898302044 0.937265693493032 0.3486219051706387 1.0 0.6018190313386066 6 O00170 1 +Laryngotracheomalacia 0.5509627287715628 0.9371544463279096 0.3486791182040001 1.0 0.6018190313386066 6 Q9Y4A5,O75369,Q14807 3 +Elevated tissue non specific alkaline phosphatase 0.4246108585729832 0.935602615862997 0.349477827237806 1.0 0.6029249963314883 3 Q96NT0 1 +Scleroderma 0.508644566104394 0.9349610413583092 0.3498083772314075 1.0 0.6029551225535639 5 Q14739 1 +Progressive neurologic deterioration 0.3987261608160234 0.9321100086068238 0.3512796761271821 1.0 0.604537580991891 21 P07602,O43681,P16278,Q10713 4 +Furrowed tongue 0.5079179525462104 0.9315260543825452 0.3515815136353795 1.0 0.604730773359313 5 P61978,Q9H2M9 2 +Epiphyseal dysplasia 0.5481903190976257 0.9249092928615232 0.3550130923573389 1.0 0.6085748777975806 6 Q9HC07,Q7RTS9 2 +Myoclonus 0.2951623678262075 0.923910097481466 0.3555331253901526 1.0 0.6092241530149761 78 P00846,P00403,P23378,Q14108,P50897,P07602,Q9UBX3,Q6PJG6,Q9NZJ7,P05067,Q10713,Q9Y4G8 12 +Congenital onset 0.2899157817524694 0.9221134263887436 0.3564694143155456 1.0 0.6099291623634587 105 Q15125,Q9NZJ7,Q00535,P08670,Q9BUB7,Q7LGA3,P61586,Q5KU26,O75530,P06753,P07602,O43924,O95425,Q96KP1,O15111,Q96N66,Q86XI2,P50542,Q8NFH4 19 +Abnormality of the carpal bones 0.4282939208374642 0.9211518265717756 0.3569711651575933 1.0 0.610331349617596 16 P21333,Q9Y2D4,O75369,Q14807,Q15125,Q9Y5S9,Q7RTS9,Q6DKJ4 8 +Abnormality of the lymphatic system 0.2756757923031853 0.9199183533660156 0.3576154271251799 1.0 0.6110682117215749 137 P49815,P15586,O96028,P14174,P50542,Q14108,P00813,Q15392,Q9NZJ7,Q9NZ08,P07602,P10619,P16278,Q96KP1,Q14739,P61916,Q10713,O15118 18 +Narrow nasal bridge 0.4217566139237877 0.9198155447578452 0.3576691586633382 1.0 0.6110682117215749 3 Q9H9E3 1 +Abnormal circulating sex hormone concentration 0.4103919631995744 0.9193928533806128 0.3578901260265499 1.0 0.6111531096286379 19 Q13423,Q9BZH6 2 +Abnormality of the vasculature of the eye 0.3109521211301703 0.9185743844951074 0.3583182353446639 1.0 0.6114854758004775 68 O15484,P29401,Q92620,Q9NZJ7,P35250,Q9Y6K9,P06280,P07602,P04439,P34897,Q9NZ08,P10619,Q6P2Q9,P49327,P00846,O00462,Q92766,P16278,Q14739,Q9UIG0 20 +Subcutaneous hemorrhage 0.3548830538292742 0.917558049378432 0.3588502889596177 1.0 0.6119440285276342 36 Q05655,P49327,O00170,P49257,Q14108,Q92766,P35579,Q8NCH0,Q13126 9 +Abnormal vitamin b12 level 0.5464613549105609 0.9172817731604764 0.3589950059659597 1.0 0.6119628090525876 6 Q05655,P41440 2 +Abnormal cartilage morphology 0.4462011796367831 0.9164387210999574 0.3594368341128788 1.0 0.612259914303925 12 P50542,Q7LGA3,O75369,Q9H9Y6,Q06124,Q9UHX1 6 +Basal ganglia calcification 0.5460159055305422 0.915317773794582 0.3600248309518645 1.0 0.6130333524057604 6 Q9Y3Z3,P00403,O60313 3 +Joint swelling 0.5458248704667339 0.9144756412463336 0.3604669716143642 1.0 0.6135579505685924 6 O00170,P14174 2 +Middle age onset 0.4994133827526603 0.9134568989428876 0.3610022920851774 1.0 0.6142407029270844 9 P07602,P31930 2 +Nonprogressive 0.5039849419062384 0.9129574886568992 0.3612649002176795 1.0 0.6143285548433441 5 Q10713 1 +Multiple joint contractures 0.4028829979453391 0.912848234313976 0.3613223660996902 1.0 0.6143285548433441 20 Q15043,O75844 2 +Gastric ulcer 0.4203905991393522 0.9122708217356342 0.3616261702496928 1.0 0.6146167772866112 3 Q8N5K1,P04062 2 +Abnormal facial expression 0.3719137199285038 0.9116874918497636 0.3619332503178931 1.0 0.6146843148908194 29 P35270,Q9NR77,Q15043 3 +Postaxial polydactyly 0.4205402564560874 0.9069621361430296 0.3644268205646739 1.0 0.617770947305375 17 Q86XI2,O43924,Q15125,Q14739,Q10713 5 +Abnormal metabolic brain imaging by mrs 0.4307300451390253 0.9042604946434614 0.3658572893557106 1.0 0.619966239682002 15 P07602,Q9NZJ7,P00403 3 +Thoracic kyphosis 0.4198679891969495 0.9026626353779876 0.3667049728102509 1.0 0.6203961645230421 17 O95831,Q9UHX1,Q14807,Q7RTS9 4 +Muscle spasm 0.3127791002404036 0.9002310835857621 0.3679972876143638 1.0 0.621980644538753 59 P07737,P00846,P05023,P06280,Q9NR77,Q15165,O95425,Q92804,P40939,P09622,P53985,Q709C8,Q99497,P13473,P49773,Q9H6K4,Q9Y6X9 17 +Status epilepticus 0.3431705146801251 0.898533763206693 0.3689010534464287 1.0 0.6232780072441139 43 P49815,P50542,Q15392,P42892,P07602,P51970,Q9NZJ7 7 +Soft tissue sarcoma 0.3650016546534704 0.8940526126693279 0.3712937418127988 1.0 0.6267672116649061 30 P49815,Q05655,P49327,P63167,Q15392,Q9BZE9,O14965,Q13126 8 +Abnormality of the gallbladder 0.3500883496535898 0.8936410582815882 0.3715139709956063 1.0 0.6267672116649061 38 O96028,Q92766,Q9UIG0,P07602,O43681,P22830,Q9NZJ7,Q69YQ0 8 +Abnormal right ventricle morphology 0.5112648358375882 0.8927073037819686 0.3720139380157241 1.0 0.6273706345147001 8 P06753,Q9H267,P21333,P11047 4 +Abnormal liver morphology 0.2448347630502803 0.8924611857629937 0.3721457882253465 1.0 0.6273706345147001 222 P15586,P11717,Q14108,P09601,P22830,Q9NZJ7,P49815,P14174,Q9BUB7,P00813,O43772,P07602,P09622,P55263,O15118,Q8N511,Q86Y39,P40939,P10619,P61916,P00846,Q9HC07,P50542,Q15067,P53634,P16278,Q14739,Q9Y619,Q10713 29 +Aplasia hypoplasia of the eyebrow 0.3405507641937686 0.8912924863318965 0.3727722785323357 1.0 0.6281595296912384 44 P48449,O75531,P00813,Q08J23,Q5SRE5,O60828,O75844 7 +Abnormal enchondral ossification 0.3646388340151896 0.8910763102533032 0.3728882329410301 1.0 0.6281595296912384 30 O96028,P50542,Q14807,Q15125,P08236,O00116,Q7RTS9,Q14739,Q9Y619,Q9UBM7 10 +Abnormality of pelvic girdle bone morphology 0.2742222040613368 0.8903860954993335 0.373258605861853 1.0 0.6284004637907207 143 O96028,Q15125,Q9NPF4,Q7RTS9,Q9Y584,P35250,O95831,Q9UPW6,P00813,Q7LGA3,O75530,Q8IZA0,Q14807,P06753,Q9BTW9,Q9Y487,O75718,P08236,Q9UHX1,O75844,Q01968,P50542,Q9H7D7,Q9UIG0,Q8IWS0,P16278,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4 31 +Malrotation of small bowel 0.458897267656294 0.8890135049687871 0.373995821836754 1.0 0.6290991828544004 4 O96028 1 +Coma 0.3516178962320375 0.8886124317235173 0.3742114075273659 1.0 0.629227061467232 36 P11182,Q13423,O43772,P40939,Q9Y619,P05067 6 +Abnormal conjunctiva morphology 0.3752426287794259 0.8883606283026798 0.3743467966736449 1.0 0.629227061467232 25 P49327,P06280,P34897,O00462,Q9NZ08,P10619,Q14739 7 +Pediatric onset 0.2452223018308906 0.8877493493155555 0.3746755939155739 1.0 0.6295485291305367 220 Q9NR77,Q99797,P35270,O60220,O95298,P22830,Q9NZJ7,Q70HW3,P49815,O95831,Q9Y4I1,Q5JRX3,P06753,P07602,P55263,P41440,P51970,O15118,Q14566,O95425,P78527,P40939,Q96KP1,P09884,Q15067,P16278,Q6PJG6,Q10713,Q69YQ0 29 +Abnormal anatomic location of the heart 0.4766978511492312 0.8840267835682926 0.3766817546988492 1.0 0.6319913457685604 10 O75844,O60828 2 +Increased susceptibility to fractures 0.3232809452018986 0.8832046665492492 0.3771257007329618 1.0 0.63227264917757 51 Q9BZH6,Q14108,P06753,O60220,O15269,Q14739,Q13126 7 +Hypothermia 0.4764514282915471 0.8827474221021301 0.3773727538694875 1.0 0.6323504214742065 10 O43772 1 +Psychomotor retardation 0.3523754486818233 0.8814062511951981 0.3780979754093367 1.0 0.6329752865576205 34 O95831,Q9BUB7,P16278,Q9Y619,Q9BV10 5 +Abnormality of the antihelix 0.4753578360664125 0.8770725466800218 0.3804472350498256 1.0 0.6357769306163061 10 Q08J23,P98175,Q5SRE5 3 +Occipital meningocele 0.5364112169939859 0.8730939842140679 0.3826118526044841 1.0 0.6384303497523602 6 Q10713,Q92766 2 +Abnormality of immune serum protein physiology 0.5217918016372106 0.8715023414779278 0.383479927945165 1.0 0.6394126157395338 7 Q05655,P09884 2 +Limb girdle muscle weakness 0.3859471875695916 0.8692602730707251 0.3847047868068669 1.0 0.640754661286401 22 P06753,P07602,Q13126,Q9Y6X9 4 +Polydactyly 0.3447637529231559 0.8685770716315621 0.3850784999708661 1.0 0.6410929198842419 40 Q92890,O96028,P21333,P98175,Q86XI2,O43924,P61978,Q8TD19,Q15125,Q9Y263,Q13045,Q92766,Q15067,Q9UBM7,Q14739,Q9UHX1,Q10713 17 +Fluctuations in consciousness 0.5352801947092505 0.8681384594569809 0.3853185390246767 1.0 0.6410929198842419 6 P00403 1 +Abnormality of the biliary system 0.2831288345640675 0.8675594745627593 0.3856355397674293 1.0 0.6410929198842419 111 O96028,P14174,P50542,Q14108,Q9NZJ7,P07602,P09601,O43681,Q14739,P40939,P55263,P22830,P61916,Q10713,O15118,Q69YQ0 16 +Abnormality of long bone morphology 0.2698769874339629 0.8674771747123864 0.3856806127907544 1.0 0.6410929198842419 169 O96028,Q9NR77,Q15125,Q7RTS9,P49773,P35250,Q13126,O95831,O00170,P98175,Q9UPW6,P00813,Q7LGA3,O75530,Q14807,Q08J23,Q9BTW9,Q9BV10,Q9Y487,O75718,P08236,Q9UHX1,O75844,Q01968,Q9HC07,P50542,Q9H7D7,Q9UIG0,Q9H9E3,P16278,O00116,Q14739,Q9Y619,Q9UGU0,Q6DKJ4 35 +Decreased circulating progesterone 0.5350511247537485 0.8671352544351265 0.385867906161246 1.0 0.6410929198842419 6 P49770,Q13144 2 +Abnormal circulating progesterone level 0.5350511247537485 0.8671352544351265 0.385867906161246 1.0 0.6410929198842419 6 P49770,Q13144 2 +Diabetes insipidus 0.4292727424315794 0.8669083979768281 0.3859922017735233 1.0 0.6410929198842419 14 P06280,Q01968,Q9BZH6 3 +Pes valgus 0.5207648276680278 0.8668273391597288 0.3860366201702672 1.0 0.6410929198842419 7 P06753,Q9UHX1 2 +Neoplasm of the oral cavity 0.4556849553923775 0.8656723815896402 0.3866698497930707 1.0 0.6416924954687763 11 Q05655,P49327,O43924 3 +Arthralgia 0.3513099261475658 0.863161377982822 0.3880487453070085 1.0 0.6432433770479256 32 Q05655,P49327,O00170,P14174,P06280,Q9UIG0,P55072,Q01130,Q9NZ08,Q15800,P35250 11 +Genu varum 0.4551835831828646 0.8629471415451208 0.3881665299118135 1.0 0.6432433770479256 11 Q9Y619,Q14807,Q7RTS9,Q96HY6 4 +Ascites 0.3689455452423757 0.8617157663899535 0.3888439473609884 1.0 0.6441327350963604 26 Q14108,P61916,O15118,Q14739 4 +Abnormality of skull ossification 0.4546187535120091 0.8598783077097237 0.3898561272452552 1.0 0.645575793922407 11 O75718,O75844,Q14739 3 +Abnormality of pain sensation 0.3656437568011272 0.859461681335855 0.3900858520818235 1.0 0.6457225840790258 27 Q9NR77 1 +Abnormality of the ankles 0.3351622211628636 0.8582292237541278 0.3907659021083915 1.0 0.6463807495302163 45 O95425,Q9UIG0,P06753,P07602,O60220,Q7RTS9,Q9NZJ7,Q15043,O75844 9 +Abnormal right atrium morphology 0.4104601125455058 0.8576590028404859 0.3910807842598736 1.0 0.6466679008516768 3 Q14315,O95235 2 +Abnormal uvea morphology 0.2890443636915628 0.8573578853314257 0.3912471267513642 1.0 0.6467093171328977 94 O96028,O15484,Q9NR77,Q9H9Y6,P35250,P49815,P21333,Q9Y6K9,P14174,Q9Y4I1,Q7LGA3,P61586,P78318,P04439,Q05655,O14617,P40939,Q9UHX1,P49327,Q01968,P50542,Q9Y619,Q9UIG0,Q9UBM7,Q10713 25 +Retinal hemorrhage 0.5181450776908083 0.854916923429341 0.39259714098693 1.0 0.6482384972212044 7 Q9Y487,Q9Y6K9 2 +Absent testis 0.4519867549668713 0.8542008206358278 0.3929937285797455 1.0 0.6486593204866554 4 Q9NVI1,P38398,Q9BXW9 3 +Glossoptosis 0.5319680466053192 0.8536483036102621 0.3932998859689207 1.0 0.6486967848936037 6 Q9H9Y6,P98175 2 +Carpal bone hypoplasia 0.5317642011523432 0.8527576039266337 0.3937937391720878 1.0 0.6488099151154233 6 Q9Y2D4,Q14807,Q7RTS9 3 +Aplasia hypoplasia involving the carpal bones 0.5317642011523432 0.8527576039266337 0.3937937391720878 1.0 0.6488099151154233 6 Q9Y2D4,Q14807,Q7RTS9 3 +Hepatic failure 0.3173416823366493 0.8502825673611195 0.3951680062007399 1.0 0.6501380173906494 52 P00846,P50542,O43772,P40939,P09622,P22830,Q9Y619,Q10713,O15118 9 +Spastic tetraparesis 0.3641113627607646 0.8477216147874768 0.3965930258236574 1.0 0.6517796334631525 28 P07602,Q7RTS9,P00846 3 +Juvenile onset 0.3436105612650263 0.8460202934322228 0.3975414234986796 1.0 0.6525993252708331 39 Q14566,Q9NR77,P06753,P16278,P41440,O15118 6 +Brisk reflexes 0.3862426960010407 0.8440844756112883 0.398622202112485 1.0 0.6536282132837482 21 P20674,Q5JRX3,Q99720,O15382,Q10713,Q9BTW9 6 +Hyperinsulinemic hypoglycemia 0.5296896948687925 0.843700522159177 0.3988367756898414 1.0 0.6536282132837482 6 P40939,P53985,P00367 3 +Abnormal circulating proteinogenic amino acid derivative concentration 0.3738691816397494 0.8428922240411146 0.3992887228187372 1.0 0.6536282132837482 24 P00846,P20674,Q9BUB7,P11182,Q99797,P22695,O95298,P32929 8 +Supernumerary bones of the axial skeleton 0.5291495732197553 0.8413446651340721 0.4001548752846915 1.0 0.6545778642523349 6 Q9Y6K9 1 +Abnormality of the radioulnar joints 0.4071499503475604 0.8395579223783074 0.4011562999910194 1.0 0.6550454459717787 3 Q9Y2D4,P16435 2 +Radioulnar dislocation 0.4071499503475604 0.8395579223783074 0.4011562999910194 1.0 0.6550454459717787 3 Q9Y2D4,P16435 2 +Inappropriate behavior 0.4198140384127912 0.8377826330545204 0.4021527942505281 1.0 0.656106005192863 15 P07602 1 +Thick cerebral cortex 0.4482918994314658 0.8356674211544831 0.4033420280129165 1.0 0.65628912051181 4 Q9Y487 1 +Diffuse white matter abnormalities 0.5138135409882684 0.8352743787535536 0.4035632397500741 1.0 0.65628912051181 7 P16278 1 +Fragile nails 0.4835955906792227 0.8351182976875677 0.403651105291829 1.0 0.65628912051181 9 Q13555 1 +Osteopenia 0.3033599757401968 0.8346037177236247 0.4039408682365784 1.0 0.65628912051181 69 O00170,Q9BZH6,Q9UPW6,Q14108,Q9Y487,O75530,Q9UIG0,P07602,Q9NZJ7,Q13126,O75844 11 +Difficulty walking 0.3030978648747013 0.8314370548485419 0.4057267733446796 1.0 0.6580479948967395 69 P00846,Q9NR77,Q99720,P06753,P07602,O43681,Q15067,Q7RTS9,Q9NZJ7,Q9Y6X9 10 +Abnormal finger phalanx morphology 0.2695350857239661 0.8307945239089589 0.4060897167394963 1.0 0.6584033416637176 161 Q03164,O96028,Q15125,Q9NPF4,Q7RTS9,P49773,Q07020,Q9Y6K9,P98175,Q9UPW6,Q9BUB7,Q7LGA3,O75530,Q14807,Q08J23,Q9H4L7,O43924,O15111,O60828,Q9UHX1,Q9Y6X9,O75844,Q01968,O75531,P61313,Q92766,Q15067,Q13045,Q8IWS0,P53634,Q9H9E3,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4 37 +Rhabdomyolysis 0.4272067002116974 0.8296918123110394 0.4067130518591764 1.0 0.6591804668411652 13 O43772 1 +Delayed myelination 0.2811860959479422 0.8289651345849948 0.4071241363916131 1.0 0.6596131583236862 80 O95831,Q9Y6X9,Q9UPW6,Q8IYI6,Q7LGA3,Q5KU26,Q2TAA5,Q6PJG6,Q5SRE5,Q9Y3B2,Q9Y584,Q9BV10 12 +Vitiligo 0.525652991173188 0.8261169107288006 0.4087377756876496 1.0 0.6615250351210651 6 P00403 1 +Multifocal cerebral white matter abnormalities 0.4849643599650295 0.823838243727292 0.4100314742262569 1.0 0.6621505775248043 5 Q9Y619,P10253 2 +Proximal upper limb amyotrophy 0.4966956597863763 0.8237594913932421 0.4100762288282009 1.0 0.6621505775248043 8 Q8WXH0,Q9Y6X9 2 +Abnormality of the musculature of the upper arm 0.4966956597863762 0.8237594913932413 0.4100762288282014 1.0 0.6621505775248043 8 Q8WXH0,Q9Y6X9 2 +Hyperconvex nail 0.496332438884008 0.8220505611195016 0.4110481212778085 1.0 0.6631537719733979 8 Q9Y619,P42892 2 +Abnormal retinal vascular morphology 0.3271362611800285 0.8209233480534919 0.4116899309339337 1.0 0.663955184596411 47 P00846,P04439,Q9Y6K9,O15484,Q92766,Q9UIG0,P07602,P10619,P16278,Q9NZJ7 10 +Brittle hair 0.4120195437677408 0.8198734582501872 0.4122882489133621 1.0 0.6644518715762178 16 Q6PGP7,O75844,O60828 3 +Hemolytic anemia 0.3510346619399516 0.8190972708810942 0.4127309188612758 1.0 0.6649311565040688 31 Q05655,P00813,P09601,P36551,P22830,P41440,P00390 7 +Persistence of primary teeth 0.5232028605511387 0.8154714445288808 0.4148025034709717 1.0 0.6673290187650747 6 P61586 1 +Postural instability 0.3999564314854508 0.810942394672556 0.417398752659341 1.0 0.6707984869809704 18 Q8WVX9,Q9NR77,O60220,Q709C8,Q99497,O75503,P41440 7 +Abnormal form of the vertebral bodies 0.2817423421049823 0.8081408523278609 0.4190095025118587 1.0 0.6731502743154839 83 P15586,O96028,Q15125,Q7RTS9,P35250,O95831,Q9Y6K9,O00170,P00813,Q14807,Q9BV10,P08236,Q9UHX1,Q01968,Q13045,Q9H9E3,P16278,Q14739,Q9Y619,Q9UIG0,Q10713 21 +Proximal muscle weakness in upper limbs 0.4142470953428349 0.8041391740142826 0.4213166026969865 1.0 0.6763823537510022 15 P36551,Q9Y6X9,P50336,P55072 4 +Abnormality of extrapyramidal motor function 0.300326804538939 0.8034743983352071 0.4217005885171081 1.0 0.6765727140486972 70 O14949,P11802,P35270,O75251,Q9NZJ7,P35250,Q9NYB0,Q15043,Q13057,P98175,P06753,P07602,Q709C8,P05067,O75569,Q99720,P31930,Q99497,Q9H6K4,P08243,P54136,P55072,P16278,Q9UIG0 24 +Abnormality of the gastric mucosa 0.4093106757081419 0.8031662706202762 0.4218786379495263 1.0 0.6765727140486972 16 Q05655,Q9UIG0,Q14739,P35250,Q6PGP7 5 +Abnormality of skeletal muscle fiber size 0.4092586111190444 0.8028456414309687 0.4220639580578431 1.0 0.676632832234938 16 O95831 1 +Broad distal phalanx of finger 0.5197003932356283 0.8002912468982337 0.4235420732936914 1.0 0.6785271506703625 6 Q7LGA3,Q14807 2 +Myositis 0.4764268150464703 0.7999388794013694 0.4237462102747984 1.0 0.6785350596558264 9 P22626,P49327,Q9NZ08,Q9Y3Z3,P28070 5 +Peripheral neuropathy 0.2683709013850577 0.7995151651798125 0.4239917567436451 1.0 0.6785350596558264 157 P00403,P26358,Q9NR77,O43681,O60220,O15269,P49773,O95831,Q5KU26,P07602,P41440,P40939,P31930,Q9Y6X9,P00846,Q8IV08,P50542,Q15067,Q10713 19 +Abnormality of humoral immunity 0.3038229711681579 0.7988969252387706 0.4243501819921553 1.0 0.6786340960789989 57 Q9Y6K9,P14174,Q14108,P00813,P09601,O60220 6 +Abnormal peripheral nervous system morphology 0.2684055354747212 0.7946467144944741 0.426819036484154 1.0 0.6813919532570536 154 P00403,P26358,Q9NR77,O43681,O15269,P49773,Q15043,P49815,O95831,P06753,P07602,P41440,Q9BV10,Q99720,P31930,Q9Y6X9,P00846,Q8IV08,P50542,Q15067,Q9Y619 21 +Colitis 0.4750056444013269 0.7929925180944246 0.4277821819204503 1.0 0.6822156956968297 9 Q05655,Q6PGP7,P09884 3 +Generalized abnormality of skin 0.2458860599860078 0.790364468633388 0.4293149465354311 1.0 0.6841833253108176 213 P00403,Q14108,Q96NT0,Q15125,O15269,P35579,P22830,P35250,Q6PGP7,Q13126,P49815,P21333,Q9Y6K9,O00170,P98175,P06280,Q9Y4I1,P00813,Q8IZA0,O43772,Q01130,P50336,Q08J23,P36551,O15118,Q9H4L7,Q05655,Q9Y487,P10619,P09884,Q8NCH0,P61916,Q9H488,O75844,P00846,P49327,P49257,P28340,P50542,Q06136,Q92766,Q9H9E3,P16278,Q14739,Q9UIG0,Q9UBM7 46 +Distal amyotrophy 0.3086228530035895 0.7881700557779104 0.430597241848067 1.0 0.6856160454177516 53 Q13057,Q9NR77,Q99720,P06753,O15269,Q9UHD1,P49773,Q9BUK6,Q9Y6X9 9 +Corneal erosion 0.4387417218542884 0.7880570350819319 0.430663345111653 1.0 0.6856160454177516 4 P51648,Q96EK5,P01889 3 +Abnormal social behavior 0.3009172577954656 0.7854535816442378 0.4321876757546636 1.0 0.6873255705104571 66 P49815,Q9Y6M9,Q86Y39,Q2TAA5,Q9NZJ7,Q5KU26,Q15125,Q9UIG0,Q15067,Q96CU9,P07602,O43681,O95298,P09884,O75251,P35250,Q9UHX1,P05067 18 +Abnormal aortic arch morphology 0.457400437217568 0.784622912229183 0.4326746922586677 1.0 0.6878610859562078 10 Q9UHX1,Q92890,Q9H7D7,Q92766 4 +Absent hair 0.4228145435258572 0.7829114975660404 0.4336790852812593 1.0 0.6887401711770729 12 P36507,Q07954,Q9H9Y6,P62304,O75844 5 +Vocal cord paralysis 0.3954131897628944 0.7816686735220382 0.4344093165258429 1.0 0.6894214430439608 18 Q9NR77 1 +Broad nasal tip 0.3229048389250669 0.7793001363776352 0.4358029343662992 1.0 0.6911538567548688 47 O95831,Q9Y4W2,O43924,Q7LGA3,Q9Y487,P16278,P10586,Q6DKJ4 8 +Female sexual dysfunction 0.5012072855264528 0.7785064991971626 0.4362704766789935 1.0 0.6916222103132968 7 O00170,Q9BZH6,Q709C8 3 +Titubation 0.4561582420538667 0.7782859299612607 0.4364004682946911 1.0 0.6916222103132968 10 Q6PJG6,Q99720 2 +Fatigable weakness of swallowing muscles 0.4394284692215502 0.7779387771266737 0.436605106661394 1.0 0.6917070173725167 11 Q92804,P07737,Q15165,P55072 4 +Dermal atrophy 0.3579483265006145 0.7770268339495492 0.4371429388312451 1.0 0.692319457104017 26 O00170,Q15392,P53634,Q8NCH0,O75844 5 +Gastrointestinal inflammation 0.3763396919415426 0.7750358277311995 0.4383184891763314 1.0 0.6937825073713143 21 Q05655,P49327,P08183,P09884,Q6PGP7 5 +Involuntary movements 0.2447891045281046 0.7746923447265908 0.4385214756008766 1.0 0.6937825073713143 306 O96028,P00403,P26358,Q14108,Q9BWD1,Q9NR77,P35270,O43681,O60220,P49773,Q9NZJ7,Q15043,P49815,P07737,O95831,Q9Y4I1,Q9BUB7,Q5JRX3,P07602,Q08J23,P41440,P05067,P32929,O75569,Q9BZH6,O43924,Q99720,P50897,P31930,Q96N66,P61916,Q9UHX1,Q9UBX3,Q9NZ01,Q9Y4G8,Q9Y6X9,P00846,P23378,Q9H7D7,Q6PJG6,O75503,Q9Y619,Q9UIG0,Q10713 44 +Anteverted ears 0.3550628722700271 0.7714933296846136 0.4404145746057533 1.0 0.6952579300086773 2 P27635 1 +Depression 0.2813151490255713 0.7712276988194834 0.4405719789199311 1.0 0.6952579300086773 101 P00403,Q2M389,P26358,O43681,Q9NZJ7,Q6DKK2,P35250,P49815,P07737,Q13057,O00170,P06280,P15289,Q15165,P07602,P36551,Q08J23,Q709C8,Q9BUK6,Q9BZH6,P50897,Q92804,Q99497,P31930,Q96N66,Q9NZ01,Q01968,Q92766,P55072,Q9UIG0 30 +Skin plaque 0.5126810406695144 0.7700104171768463 0.4412937133500534 1.0 0.6955763203487769 6 P49815,Q06136 2 +Dilated cardiomyopathy 0.3338880099622393 0.7695139560780961 0.4415882627882532 1.0 0.6957485297011481 40 P00846,P00403,P06753,P40939,P16278,P09493 6 +Sporadic 0.3638887540794732 0.7690319037188114 0.4418743712456034 1.0 0.6958732808281128 24 P49815,Q9BWD1,Q69YQ0 3 +Weakness of muscles of respiration 0.3396629188581563 0.7676630867570147 0.4426873718011563 1.0 0.6962818215580386 33 O95831,P60174,P10253,P55072,P06753,Q15067,P50336,P36551,Q7RTS9,Q8WXH0,Q9Y6X9 11 +Progressive sensorineural hearing impairment 0.4538344813465997 0.7664543181031486 0.4434060233267232 1.0 0.6971725760104472 10 O60220 1 +Fatigable weakness of respiratory muscles 0.4193709677011547 0.7635141408494655 0.4451568322660517 1.0 0.6987252473531271 12 Q92804,P07737,Q15165,P55072 4 +Zonular cataract 0.4688654141168687 0.7630952363977832 0.4454066007626998 1.0 0.6987998288563495 9 Q01968,P08670,Q99797 3 +Respiratory insufficiency 0.2634474724941678 0.761009296183668 0.4466515147470948 1.0 0.6998712711391486 172 Q9NR77,Q5SRE5,Q7RTS9,Q9NZJ7,Q70HW3,P49815,O95831,Q9BUB7,Q15165,O43772,P06753,P07602,Q08J23,Q86Y39,P40939,P61916,Q9Y6X9,P50542,Q15067,Q14739,Q9Y619 21 +Abnormal upper motor neuron morphology 0.483033708701004 0.7598739364401726 0.4473299423236889 1.0 0.7004547198137271 8 P55072,Q99720 2 +Coxa valga 0.3918642232027394 0.758914513850769 0.4479036961731557 1.0 0.7011132754393071 18 P16278,O75530,O75844 3 +Hypertonia 0.2373310784857679 0.7526480424249083 0.4516614398856005 1.0 0.7051456213865797 360 P26358,Q15125,Q99797,P35270,P42695,O43681,O60220,O95298,Q7RTS9,Q9UHD1,Q9NZJ7,Q15043,P07737,O95831,Q9Y6K9,Q9UPW6,Q9Y4I1,Q7LGA3,Q5KU26,Q15392,Q15165,O75530,P07602,P09622,Q08J23,P51970,P05067,O15118,Q8IYI6,P11182,Q99720,P50897,Q96KP1,P31930,P09884,O60828,P61916,Q9UBX3,Q9Y6X9,P00846,Q86XL3,Q86XI2,P50542,Q15067,P16278,Q6PJG6,Q14739,Q9Y619,Q9UGU0,Q10713 50 +Pace of progression 0.2660421873371232 0.7525635157437998 0.4517122486138194 1.0 0.7051456213865797 154 O95831,Q8IV08,P15586,O75569,P26358,Q14108,Q9NR77,Q99720,Q6PJG6,P55263,P41440,P49773,Q13126,Q15043,Q9Y6X9 15 +Abnormal ilium morphology 0.3789418420644236 0.7498123696498787 0.4533677177482969 1.0 0.7070064886316711 20 O95831,P16278,O75530,Q7RTS9 4 +Chronic diarrhea 0.3842124656917509 0.7455899947883383 0.4559151286838871 1.0 0.709848220384178 19 P00813,Q08J23 2 +Asymmetric growth 0.416169610543701 0.7455547078381556 0.4559364516090829 1.0 0.709848220384178 12 Q9Y6K9,P07437,Q9UPW6,Q15125,P31751 5 +Congestive heart failure 0.2989970154764712 0.7454419376864359 0.4560045992447272 1.0 0.709848220384178 57 P21333,P00403,Q9Y6K9,P07437,P06280,Q9BUB7,Q9UIG0,P55072,P40939,P16278,Q9BU61,P35250,P09493,Q70HW3 14 +Neuronal loss in basal ganglia 0.4679304838958933 0.7452501361463363 0.4561205191500694 1.0 0.709848220384178 5 Q99986,Q9BU61 2 +Positional foot deformity 0.2803095503124703 0.741567668820945 0.4583493184118459 1.0 0.7121061881775352 97 O96028,P52788,Q9NR77,Q15125,Q7RTS9,P21333,P98175,Q9UPW6,Q15392,O75530,P06753,Q9H267,P32929,Q9BV10,Q9Y487,P08236,Q8NCH0,Q9UHX1,P50542,Q92766,Q9Y619,Q9H9E3,Q9UBM7,Q69YQ0 24 +Sparse and thin eyebrow 0.4153209666302354 0.7408062982257441 0.4588108958276136 1.0 0.7125095428227299 12 P48449,O75531 2 +Lower limb hypertonia 0.4484862832519621 0.7393428624479549 0.4596988282483449 1.0 0.7134762756502796 10 Q8WVX9,O60341,P21912,P31040,P54136,Q14739 6 +Dyslexia 0.4665317838075582 0.7388597536362503 0.4599921632136945 1.0 0.7136895359420609 5 Q9H6K4,P55072 2 +Variable expressivity 0.293867989931353 0.7376609861546144 0.4607204854936952 1.0 0.7145773168772088 72 P00403,Q9UEY8,Q9H7D7,Q9NR77,Q15125,Q9BUF5,P35270,P06753,P07602,P09622,Q9H061,Q9NZJ7,Q70HW3 13 +Skin erosion 0.4781363338943937 0.7371897783616899 0.46100694858927 1.0 0.7146339699495285 8 P50336,O75844 2 +2 3 toe cutaneous syndactyly 0.3491065519523565 0.7364606634335803 0.4614503982565245 1.0 0.7146339699495285 2 P27635 1 +Meningitis 0.4914553571655793 0.7350610078442951 0.4623023399452055 1.0 0.7151991757828948 7 Q9NZ08 1 +Wormian bones 0.3928787592262835 0.7323336308505715 0.4639649571084809 1.0 0.7162116724065827 17 O75718,O95831,Q9Y487,O75844 4 +Hyperpigmentation of the skin 0.2804094007841827 0.7315138125451541 0.4644653708323969 1.0 0.7167424148010386 91 P49815,Q9Y6K9,O75531,Q9Y4I1,Q7LGA3,Q8ND04,Q13423,P09884,Q14739,Q9UGU0,Q6PGP7,O75844 12 +Polyphagia 0.4902476134104048 0.729712401491926 0.4655659990288758 1.0 0.7179567309821984 7 Q9BYW2,Q9H2P0,P35222,Q9UPW6 4 +Abnormal peripheral action potential amplitude 0.4753769656326337 0.7244647807763188 0.4687804416477081 1.0 0.7212067558392903 8 P31930,Q9Y6X9 2 +Acute coronary syndrome 0.3864189602453858 0.7242144565589944 0.4689340846357281 1.0 0.7212067558392903 18 P49327,P35250,Q9NZ08,P35579,Q9UIG0,O75844 6 +Decreased testicular size 0.3688921064081811 0.7236882764047335 0.4692571321786318 1.0 0.7214611669404091 21 P09884,Q9BZH6,O60828 3 +Abnormal abdomen morphology 0.2464472666596139 0.7208154377684468 0.4710230758811846 1.0 0.7233137973824668 207 P15586,Q14108,Q96NT0,P09601,O75251,Q9NZJ7,Q6PGP7,P49815,P14174,Q9BUB7,P00813,Q15392,O43772,P07602,P09622,P36551,Q96CU9,O15118,Q9Y6M9,Q05655,Q86Y39,O14617,P08236,Q9NZ08,P40939,P10619,P35573,P31751,Q9BU61,P61916,P00846,P49327,Q9HC07,P50542,Q92766,Q15067,P16278,Q14739,Q9Y619,Q10713 40 +Subcutaneous nodule 0.3909368232811404 0.7202918966717937 0.4713452929286943 1.0 0.7234565411584956 17 P49815,P49327,Q01968,P06280,P11802,Q9NZ08 6 +Hypoplasia of teeth 0.3742062189482364 0.7181269179925823 0.4726790342021476 1.0 0.7247745191099597 20 P61586 1 +Abnormality of the mitochondrion 0.2782229172805006 0.7168297193717348 0.4734791715163573 1.0 0.7252724792604979 88 P00846,P00403,P26358,Q86Y39,Q9BUB7,P50542,O43772,P40939,P09622,P51970,Q9Y584,Q9UBX3,Q70HW3 13 +Inability to walk 0.275554834701196 0.7147944785022914 0.474736047492212 1.0 0.7264683682286373 84 P00846,O14949,Q9NR77,Q99720,O60220,O15269,Q7RTS9,Q96N66,O75503,P49773,Q96CU9,Q8N201,Q9BTW9,Q15043,Q9Y6X9 15 +Abnormal acetabulum morphology 0.3735600493454653 0.7138212628992016 0.4753377098403741 1.0 0.7264819227737601 20 O75718,Q9Y584,P16278,Q7RTS9 4 +Abnormal umbilicus morphology 0.2961088043023724 0.7124785141862768 0.4761685116738854 1.0 0.7272016276047293 59 P21333,Q9Y6K9,Q01968,Q15022,Q69YQ0,Q9BUB7,Q9Y487,O75530,P08236,Q92766,Q9UIG0,Q14739,Q8NCH0,P35250,Q6DKJ4,O75844 16 +Cutaneous syndactyly 0.4430418739459907 0.7119273364860702 0.4765097732947587 1.0 0.7274800641661477 10 Q9Y619,P98175,O15111 3 +Spina bifida occulta 0.3841218501833014 0.7096592370897563 0.4779154758308079 1.0 0.7286539416647595 18 P21333,Q9Y6K9,Q8TD19,P35250,Q08J23,P09884,Q9UIG0,Q9UHX1 8 +Hypoplastic nipples 0.4086492457529809 0.7036696005674229 0.4816385559999225 1.0 0.7325412403526856 12 P10586 1 +Abnormality of the vertebral endplates 0.4563111776005578 0.7026150346463154 0.482295690408336 1.0 0.7331342992357867 9 O15228,Q14807,Q7RTS9 3 +Onset 0.2332816613070639 0.7020213079003679 0.4826658752388815 1.0 0.7332099936834918 372 P26358,Q9NR77,Q15125,Q99797,P35270,O60220,O95298,P22830,Q9NZJ7,Q00535,Q70HW3,P49815,O95831,P08670,Q9Y4I1,Q9BUB7,Q7LGA3,P61586,Q5KU26,O75530,Q5JRX3,Q2TAA5,P06753,P07602,P55263,P41440,P51970,O15118,Q00839,O43924,Q14566,O95425,P78527,P50897,P40939,Q96KP1,P31751,P31930,P09884,O15111,Q96N66,P61916,Q9UHX1,Q9Y4G8,Q8IV08,Q86XI2,P50542,Q9H7D7,Q8NFH4,Q15067,P16278,Q6PJG6,Q10713,Q69YQ0 54 +Abnormal location of ears 0.2377916524016096 0.6976234974068612 0.4854126827726295 1.0 0.7359171411229961 231 Q03164,P15586,O96028,P43034,P46777,Q15125,Q9NPF4,Q5SRE5,P35250,Q8N201,Q6PGP7,Q07020,O95831,P98175,Q13555,Q9UPW6,Q9BUB7,Q7LGA3,Q15392,O75530,P06753,Q08J23,O43924,Q9Y487,Q8ND04,P42892,P78527,O14617,Q96KP1,O15111,Q8NCH0,Q9UHX1,O75844,Q01968,Q9HC07,P50542,P61313,Q92766,Q15067,Q9UIG0,P16278,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 48 +Abnormal circulating free fatty acid concentration 0.4200994282713459 0.6965918059276962 0.4860582853005741 1.0 0.7366519111989166 4 P40939 1 +Abnormality of body mass index 0.3803376365441829 0.6954376560884942 0.4867810687407656 1.0 0.737058058703741 3 P42858,Q8NI27 2 +Juvenile aseptic necrosis 0.4567939516131246 0.6946729988272422 0.4872602530916783 1.0 0.7372529515373922 5 Q9Y619 1 +Oral cleft 0.262539830521046 0.6936886603173481 0.4878774789195015 1.0 0.7374554891065253 156 O96028,P46777,P52788,Q15125,Q5SRE5,Q9H9Y6,Q8N201,Q6PGP7,Q07020,P21333,Q9Y6K9,P98175,Q9UPW6,Q7LGA3,Q15392,Q08J23,Q9BZH6,O43924,P09884,O60828,O15111,Q8NCH0,Q9UHX1,O75844,P50542,P61313,Q9H7D7,Q92766,Q13045,Q8IWS0,Q14739,Q9Y619,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 36 +Abnormality of malar bones 0.2936355069055429 0.6928357018593092 0.4884126643313413 1.0 0.7379823587016423 64 O95831,Q9Y4W2,Q9HC07,Q9UPW6,O75531,Q9Y487,P61586,Q14807,Q15125,Q92766,P35573,Q14739,O60828,Q9H9Y6,Q9H9E3 15 +Lipoatrophy 0.3813562158841951 0.6922054211304213 0.4888083347530201 1.0 0.7379823587016423 18 P09493 1 +Myofibrillar myopathy 0.3796756041045941 0.6919469420763837 0.4889706497035853 1.0 0.7379823587016423 3 Q13642,Q14315 2 +Telangiectasia 0.3302249439955474 0.6918488983180966 0.4890322250255803 1.0 0.7379823587016423 34 P00846,P10619,Q14739 3 +Abnormal circulating fatty acid concentration 0.3692773117536472 0.6853992035837078 0.4930920464800592 1.0 0.7428842319747305 20 P40939,P09622,O43772 3 +Narrow palpebral fissure 0.3973564412186707 0.6799662002038181 0.4965258627045905 1.0 0.7460596384562459 14 Q03164,Q9H2P0,Q8IWS0,P38159,Q8N201,Q53EZ4 6 +Atrophy degeneration affecting the central nervous system 0.2414103807337092 0.6797437154434885 0.4966667507922615 1.0 0.7460596384562459 286 P00403,P26358,O60220,Q9Y3B2,Q9NZJ7,Q15043,P07737,O95831,Q9Y6K9,Q9Y4I1,Q9BUB7,Q7LGA3,Q5KU26,Q15165,Q5JRX3,P07602,Q08J23,P55263,P51970,P05067,O15118,O43924,Q86Y39,Q8IYI6,Q8ND04,P78527,Q99720,P50897,P31930,P09884,O60828,Q9Y6X9,P00846,P16278,Q6PJG6,Q9Y619,Q9UGU0,Q10713,Q69YQ0 39 +Retinopathy 0.3423655225537029 0.6788400175248696 0.4972392349441885 1.0 0.7466324285240018 27 P00846,O96028,P49327,P07437,Q9Y4I1,Q9NZ08,P40939,Q9BU61,Q9NYB0 9 +Delayed puberty 0.3059115891141882 0.6785724107925795 0.4974088287277487 1.0 0.7466324285240018 50 Q01968,O00170,Q9BZH6,Q14108,Q13045,Q8IWS0,Q15800,O75844 8 +Abnormal macrophage morphology 0.4531115866231443 0.6781121672857592 0.4977005766717783 1.0 0.7466324285240018 5 P61916,O15118 2 +Foam cells 0.4531115866231443 0.6781121672857592 0.4977005766717783 1.0 0.7466324285240018 5 P61916,O15118 2 +Ulnar deviation of the hand or of fingers of the hand 0.4197962505075564 0.6741554956874551 0.5002124604491911 1.0 0.7496669509441442 11 P21333,Q9Y2D4,Q9H2M9,Q14739,Q9UBM7 5 +Supernumerary nipple 0.4029226645400477 0.6720894649801492 0.5015267428936385 1.0 0.7511413292618401 12 Q9Y6K9 1 +Skeletal myopathy 0.4515781239283216 0.671241394507517 0.5020667623358517 1.0 0.7517041449823988 5 P40939,P31040 2 +Abnormal insulin level 0.3575490358697277 0.6690569800377049 0.5034591310207128 1.0 0.7525579499287403 22 Q6P2Q9,P00367,Q16836,P40939,P53985,P31751,O75844 7 +Abnormal cardiac ventricular function 0.382410314479579 0.6678537282276285 0.5042269663892278 1.0 0.7534596229720848 17 P09622,O75844 2 +Hepatitis 0.3816858525653711 0.6634331740749091 0.5070531652611587 1.0 0.7566945997392642 17 Q05655,P49327,P11717,P08236,Q9Y619,Q9H267 6 +Relative macrocephaly 0.3262907507465578 0.6631431233096973 0.5072388943353361 1.0 0.7567250389090069 35 Q7LGA3,Q15392,Q9UGU0,Q6DKJ4,O75844 5 +Lissencephaly 0.3107027058907197 0.6612272091896395 0.5084666143716814 1.0 0.7574291959451921 47 Q86XL3,Q9Y487,Q9H7D7,Q15392,P78527,P42695,Q00535,Q9BV10 8 +Amyotrophic lateral sclerosis 0.3940577690412192 0.6611153745702597 0.5085383262266934 1.0 0.7574291959451921 14 Q15165,Q99720 2 +Cough 0.3420789978090863 0.65716639300305 0.5110739321770046 1.0 0.7599692617199968 26 P49815,Q9NR77,P41440 3 +Limb dystonia 0.3930887754015857 0.6555984642369505 0.5120825139247431 1.0 0.7606550537665645 14 Q92947,O75569,Q709C8,Q99720 4 +Abnormality of the breast 0.2734409313265507 0.6546231952534722 0.51271038624779 1.0 0.7610670630906445 100 O96028,Q9H2P0,P52788,P11802,A6NHR9,Q5SRE5,Q9NYB0,Q9Y6K9,O00170,Q15233,Q7LGA3,Q2TAA5,O75530,P52701,Q9BV10,Q01082,Q05655,Q9BZH6,Q96KP1,P31751,Q9H2M9,Q06124,P62140,P49327,Q9Y4W2,P28340,P07437,P61978,O75330,P38398,Q15067,Q8IWS0,Q07864,Q9Y619,Q9UGU0,Q9UBM7,P10586 37 +Abnormality of the diencephalon 0.3389156109629412 0.6526544544921374 0.5139790711185401 1.0 0.7622041870941327 27 Q13057,Q9BZH6,O43924,Q9UIG0,Q96KP1,P35250 6 +Abnormality of the hypothenar eminence 0.4109271523178641 0.6524617549647923 0.5141033371557873 1.0 0.7622041870941327 4 P62913,Q9NRG9,Q96IJ6 3 +Abnormality of the parathyroid gland 0.3746965201885422 0.6505149901040976 0.5153596221590497 1.0 0.7625718308616745 18 P49815,P00403,Q92766,P40939,Q08J23 5 +Epicanthus inversus 0.3717460856292976 0.6504451677756738 0.5154047094464416 1.0 0.7625718308616745 3 Q7Z6Z7 1 +Palpebral edema 0.4468709386243593 0.6502493464588865 0.5155311706365324 1.0 0.7625718308616745 5 O00170,A6NHR9,P50542 3 +Deviation of the 2nd finger 0.410376913464231 0.6498354225048704 0.5157985352615198 1.0 0.7625718308616745 4 P21333 1 +Multifocal epileptiform discharges 0.3409562475977085 0.6488169276896262 0.5164567146536583 1.0 0.7630156174854079 26 Q01082,Q9H936,Q2M389,Q08209,Q08J23,Q9UBX3,Q9NZ01,O75503,Q96N66,P62873 10 +Micromelia 0.3508751430057677 0.6473062404728411 0.5174337634741111 1.0 0.764212434792193 23 O75718,Q15392,Q07864,Q9UBM7,Q14739,Q9UHX1 6 +Abnormality of toe 0.258685963766413 0.6463960754206681 0.5180228813992613 1.0 0.7646122151343874 165 Q03164,O96028,P52788,Q9NR77,Q15125,P60953,Q9UHD1,Q27J81,P35250,Q8N201,P21333,Q92890,Q96BR5,Q9UPW6,Q15233,P00813,P61586,Q7LGA3,O75530,Q08J23,Q10471,Q9BV10,Q12830,Q9H4L7,O43924,P34897,Q8TD19,O95425,Q99720,Q9UHX1,O75844,Q9Y6X9,Q15022,Q92766,P55072,Q9UIG0,Q13045,Q8IWS0,Q93009,Q14739,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 45 +Polyhydramnios 0.3070923155053556 0.6462668313890205 0.5181065646468044 1.0 0.7646122151343874 48 Q15125,Q92766,P06753,Q14739,O75844,Q9UBM7,Q6PGP7,Q9BTW9,Q70HW3,Q9BV10 10 +Abnormal blistering of the skin 0.3630562028546 0.6444978005568589 0.5192526834132449 1.0 0.7650646307501817 20 P49327,Q9Y6K9,Q06136,Q01130,Q9NZ08,P36551,Q9H4L7 7 +Abnormal oral physiology 0.294796274215791 0.6430814190787009 0.5201712704970058 1.0 0.7657844660871006 53 P07737,P15586,Q9NR77,Q15165,P06753,Q14739 6 +Abnormal macroscopic urine appearance 0.3625595652433708 0.6412536588650638 0.5213578921015485 1.0 0.7672845891153658 20 P49815,Q92621,Q8NFH4,P36551,Q8N1F7,Q14C86 6 +Pseudobulbar signs 0.4128635445295546 0.6382258837030488 0.5233266503515879 1.0 0.7697199951255638 11 Q15233,P54136,P26358 3 +Microdontia 0.3370029129879556 0.6368526092086058 0.5242208541970454 1.0 0.7703330995430288 28 Q9UPW6,Q7LGA3,P61586,Q9Y487,Q9Y619,Q9UIG0 6 +Slowly progressive 0.2890042144269552 0.6367758888451303 0.5242708335321247 1.0 0.7703330995430288 57 O95831,Q8IV08,Q9NR77,Q99720,P41440 5 +Acetabular dysplasia 0.427777866162539 0.6361978608468704 0.524647467261675 1.0 0.7706391070785258 10 Q9Y584,P16278 2 +Broad thumb 0.3367078224344497 0.6341324069594855 0.52599441509697 1.0 0.7721220134377267 29 P21333,Q9H2P0,Q15022,Q9UPW6,Q7Z6Z7,Q7LGA3,O75530,Q08J23,Q9Y5S9,Q9UGU0,Q9UHX1,Q6DKJ4,Q12830 13 +Functional motor deficit 0.2579845630293958 0.6337362246093712 0.5262529800342459 1.0 0.7722538921502865 130 P00846,P00403,Q9NZJ7,Q9NR77,Q99720,P06753,P07602,O43681,P40939,Q15067,Q7RTS9,Q9UHD1,P49773,Q9H2D1,Q8N201,Q9Y6X9 16 +Abdominal pain 0.2680803314412934 0.6332687736274492 0.5265581413147657 1.0 0.7724540425633599 82 P49815,P14174,Q14108,Q14566,P42892,Q13423,Q9NZ08,Q70HW3 8 +Bowing of the arm 0.4426835282736791 0.6317063964821362 0.527578747536974 1.0 0.7737032769870971 5 P21333,O75369 2 +Abnormality of the nail 0.2680728506029914 0.6313142763260547 0.5278350541165562 1.0 0.773755477551368 110 P49815,Q9BV10,O96028,Q9Y6K9,P10321,O00170,Q13555,Q9UPW6,O75530,P42892,Q15125,P53634,Q08J23,Q14739,Q9Y619,O60828,Q6DKJ4,O75844 18 +Carpal synostosis 0.4675171812872806 0.6305879562230896 0.5283099757505638 1.0 0.7737839228833058 7 P21333,Q9Y5S9,Q6DKJ4 3 +Synostosis of carpals tarsals 0.4675171812872806 0.6305879562230896 0.5283099757505638 1.0 0.7737839228833058 7 P21333,Q9Y5S9,Q6DKJ4 3 +Retinal coloboma 0.4545270637126157 0.6298159093037101 0.5288150354903727 1.0 0.7740214881886348 8 Q8N201,Q10713 2 +Cutaneous cyst 0.4061590974605692 0.6297877419182816 0.5288334667523074 1.0 0.7740214881886348 4 P49815 1 +Abnormality of central nervous system electrophysiology 0.2588663585655893 0.6295645712371855 0.5289795095158509 1.0 0.7740214881886348 139 O96028,P00403,P43034,Q14108,P52788,Q15125,Q9NPF4,O60220,Q5SRE5,Q9NZJ7,Q9BQE5,Q2TAA5,P07602,Q08J23,Q00839,P48449,Q8IYI6,O14617,P50897,Q96N66,Q9UBX3,Q9NZ01,Q9Y6X9,Q01968,P50542,Q13045,Q15067,Q8IWS0,O75503 29 +Atrophy degeneration affecting the cerebrum 0.233912184939639 0.6289925357479395 0.5293539429060192 1.0 0.7740223069838923 226 P00403,P26358,Q9NPF4,O60220,Q9Y3B2,Q9NZJ7,Q15043,O95831,Q9Y6K9,Q9Y4I1,Q9BUB7,Q7LGA3,Q5KU26,Q2TAA5,Q5JRX3,P07602,Q08J23,P55263,P51970,P05067,O43924,P50897,P31930,P09884,O60828,Q96N66,Q9UHX1,Q9NZ01,Q9Y6X9,P00846,Q9UIG0,P16278,O75503,Q9Y619,Q9UGU0,Q10713,Q69YQ0 37 +Gingival bleeding 0.4110335645499202 0.6288141011300289 0.5294707672183776 1.0 0.7740223069838923 11 Q14108 1 +Spina bifida 0.3231338477052414 0.6279570559262729 0.5300320725804735 1.0 0.7740223069838923 32 Q92890,Q9Y6K9,P21333,Q8TD19,O75369,Q92766,Q9UIG0,Q08J23,Q9Y5S9,P09884,Q06124,P35250,Q9UHX1,Q10713 14 +Abnormality of the nasolabial region 0.4418080567382604 0.6278458516677743 0.5301049258350103 1.0 0.7740223069838923 5 Q9Y487 1 +Prominent nasolabial fold 0.4418080567382604 0.6278458516677743 0.5301049258350103 1.0 0.7740223069838923 5 Q9Y487 1 +Hypoventilation 0.4108443571831121 0.6278427874265478 0.5301069333836201 1.0 0.7740223069838923 11 P06753,Q9BU61,P11047 3 +Increased circulating antibody level 0.3800483663177607 0.6265545333087518 0.5309512796758131 1.0 0.7746777198202731 16 P00813,Q14108 2 +Oral ulcer 0.4657308088122285 0.622936464400518 0.5333262745479317 1.0 0.7769046335473849 7 Q9NZ08 1 +Abnormal larynx physiology 0.3904738768224595 0.6213122748202325 0.5343941789078657 1.0 0.777717696935231 13 P07737,Q9H0U9,Q15165,P55072,Q92804 5 +Lack of skin elasticity 0.3868048916601066 0.6200617650008423 0.535217123621355 1.0 0.7784203288258473 14 Q9H4L7,O00170,O75844 3 +Abnormal circulating protein concentration 0.2585950891557245 0.619416638544193 0.5356419228490861 1.0 0.7787906864295638 150 Q92621,Q96NT0,Q9NPF4,P49773,Q9Y584,P35250,Q6PGP7,O95831,P14174,Q5JRX3,O43772,P06753,P36551,Q08J23,P41440,P09493,Q9BTW9,Q9BV10,Q9BUK6,Q8N511,Q05655,Q9Y487,O95425,P40939,P35573,P53985,P13473,Q9HC07,Q8NFH4,Q9UIG0 30 +Pierre robin sequence 0.4764236475160192 0.6173872766239387 0.536979312201842 1.0 0.7800868196186767 6 P98175,Q9UPW6 2 +Camptodactyly of toe 0.4762749966034788 0.6167772855087287 0.5373816362117534 1.0 0.7800868196186767 6 Q8IWS0 1 +Migraine 0.3530787921088114 0.616771326207408 0.5373855674585291 1.0 0.7800868196186767 21 Q9NZ08,P00403,P05067 3 +Platyspondyly 0.3206558004069436 0.6160729153207296 0.537846396951742 1.0 0.7805082304527974 35 O95831,P16278,P00813,Q14739 4 +Anorexia 0.3342168550609213 0.6157667158631325 0.538048497784946 1.0 0.7805540330781926 28 Q9NZ08,Q14108 2 +Restrictive behavior 0.4029188118149728 0.6144914317411992 0.5388906333374546 1.0 0.7810330680131506 4 P55072 1 +Increased arm span 0.3644488579940361 0.6127992941482449 0.5400090576543488 1.0 0.7816639648589357 3 Q9BYW2,Q96L73 2 +Abnormal arm span 0.3644488579940361 0.6127992941482449 0.5400090576543488 1.0 0.7816639648589357 3 Q9BYW2,Q96L73 2 +Abnormality of lower limb joint 0.2573637889979915 0.6124261921719754 0.5402558169214609 1.0 0.78177390896286 161 O96028,Q9NR77,Q15125,Q9NPF4,O60220,Q7RTS9,Q9NZJ7,Q9Y584,P35250,Q15043,O95831,Q9UPW6,Q7LGA3,Q14807,P06753,P07602,Q9BTW9,Q9Y487,O75718,O95425,P08236,Q9UHX1,O75844,Q86XL3,Q01968,Q92766,Q8IWS0,P16278,Q9Y619,Q9UIG0,Q9UBM7 31 +Neoplasm of the tongue 0.4630404171449943 0.6114554527334933 0.5408981011482057 1.0 0.7824559446761497 7 Q05655,O43924 2 +Highly arched eyebrow 0.2864968494377178 0.6100134747843097 0.5418528815099446 1.0 0.7835894592957398 57 Q13555,O43924,Q7LGA3,Q5KU26,Q5SRE5,Q9UGU0,Q10713,Q69YQ0 8 +Reduced visual acuity 0.2655628644758273 0.6094067800239473 0.5422548449810569 1.0 0.7836588238530694 112 O15484,O43681,O60220,O75251,Q9UHD1,Q9NZJ7,Q15043,O00170,P61586,P07602,P09622,Q96CU9,Q9Y6M9,Q86Y39,P50897,Q9NZ08,Q9BU61,O60828,Q9H061,Q9UHX1,P00846,Q6P2Q9,P49327,P68371,Q9H7D7,P16278,Q10713 27 +Generalized hypopigmentation 0.4498295713128448 0.6089075584427953 0.5425857139590073 1.0 0.7836588238530694 8 Q6PGP7,O14617 2 +Impaired mastication 0.4617123907657277 0.6058075479422458 0.5446425569830315 1.0 0.7856378768708904 7 P06753,P11047 2 +Progressive 0.2692485990032072 0.6034642178700637 0.5461999125791897 1.0 0.7871401133107528 102 O95831,P15586,P26358,Q99720,Q6PJG6,P55263,P49773,Q13126,Q15043 9 +Severe global developmental delay 0.2831881528458741 0.6006805145253855 0.5480527997473654 1.0 0.7883072977061834 70 P00846,P50542,Q8IYI6,Q7LGA3,Q15067,Q96KP1,P55263,Q7RTS9,P51970,Q9UGU0,Q8N201,Q9BV10 12 +Adrenal hyperplasia 0.3996688741721696 0.5992457912126192 0.5490089910460494 1.0 0.7883072977061834 4 P40818,P10644,P16435 3 +Orthostatic hypotension 0.3793107759853595 0.5987370526810085 0.5493482444976496 1.0 0.7883072977061834 15 P07602,O43681 2 +Unsteady gait 0.3059395947554041 0.598668207455876 0.5493941620339524 1.0 0.7883072977061834 46 O95831,O75569,P60174,P31040,P52788,Q9NR77,Q5JRX3,P49770,P43243,Q96F07,O75503,Q9NR50,Q9H6K4,Q10713,Q13144 15 +Increased intracranial pressure 0.3709473091802802 0.5986297558971023 0.5494198088024991 1.0 0.7883072977061834 17 Q9NZ08,P07602 2 +Abnormality of female external genitalia 0.3185173295032856 0.5983845913714334 0.5495833447364673 1.0 0.7883072977061834 35 P50542,Q15392,Q08J23,Q9Y619,Q6DKJ4 5 +Hydrocele testis 0.4716276341411207 0.5977829188738938 0.5499847894490921 1.0 0.7884267734555409 6 Q9BYW2,Q9UBX3 2 +Arterial thrombosis 0.4712472834014884 0.5962350402624795 0.5510182201839882 1.0 0.7889208399511976 6 Q9NZ08 1 +Abnormality of the knee 0.2672912546764022 0.5960169878580184 0.5511638781180059 1.0 0.7889208399511976 85 O95831,Q86XL3,Q9UPW6,Q7LGA3,Q9NR77,O95425,Q15125,Q92766,P06753,P35250,Q14807,P16278,P08236,Q7RTS9,Q9Y619,Q9UIG0 16 +Abnormal mitral valve physiology 0.3165049976840635 0.5918144008608937 0.5539748787939605 1.0 0.7913696411251713 37 P21333,P49327,O00170,P46777,Q9UIG0,Q9NZ08,P40939,Q9BU61,P35250,P09493,O75844 11 +Large basal ganglia 0.3739179067869316 0.5906884246232639 0.5547292052211206 1.0 0.7916739775289798 16 Q08J23,Q96N66 2 +Gait imbalance 0.3491364673548308 0.5906505575597181 0.5547545822685755 1.0 0.7916739775289798 21 Q9NR77,Q9UIG0,O15269,Q99497,Q709C8,P35250 6 +Aplasia hypoplasia of toe 0.3179434104191024 0.590124820691854 0.5551069695015016 1.0 0.7916739775289798 34 Q03164,O96028,Q7LGA3,P00813,Q8IWS0,Q9UBM7,Q9UGU0,Q9UHX1,Q69YQ0 9 +Esophageal stricture 0.397682119205283 0.5899750827798761 0.5552073547918814 1.0 0.7916739775289798 4 O60832,P01889,Q9NX24 3 +Neoplasm of the stomach 0.3737901309614608 0.5899459474727075 0.5552268883259832 1.0 0.7916739775289798 16 O43684,P63167,P21912,P31040,P11802,P52701,P20585,O14965,P10644,Q9NYB0,P35222 11 +Shyness 0.3974249249412519 0.5887777472928439 0.5560103753125052 1.0 0.7922974744101295 4 Q15233,P09884 2 +Stroke like episode 0.4327821526411992 0.5883926800786763 0.5562687498602807 1.0 0.7923320833492359 5 P51970 1 +Abnormal electrophysiology of sinoatrial node origin 0.3867680411837535 0.5847239271062213 0.5587333627994857 1.0 0.7948928973212464 12 P06753,O75531 2 +Epiphyseal stippling 0.3804385244041484 0.584515126228513 0.558873791474715 1.0 0.7948928973212464 14 P50542,Q15125,P08236,O00116,Q14739 5 +Motor deterioration 0.4318074747371216 0.5841719584135053 0.5591046256369967 1.0 0.7949741756882678 5 P31040,O75503 2 +Cns demyelination 0.3802197442028071 0.5833022892217933 0.5596898217410409 1.0 0.7955591037604794 14 P07602,Q15067 2 +Slow saccadic eye movements 0.4306508923157978 0.5823813754955419 0.5603098237269557 1.0 0.7960114653220275 9 Q9UHD1,Q8IV08 2 +Broad long bones 0.3169842105444438 0.582312960516058 0.5603558971526268 1.0 0.7960114653220275 34 P21333,Q9H2P0,Q15022,Q9UPW6,Q7Z6Z7,Q7LGA3,O75369,Q14807,O75530,Q08J23,Q9Y5S9,Q9UGU0,Q9UHX1,Q6DKJ4,Q12830 15 +Seborrheic dermatitis 0.4436156936115047 0.5815185330792607 0.5608910312215785 1.0 0.7964299450332301 8 P29401,Q92890,Q92766 3 +Hepatomegaly 0.2551156942455453 0.5804343635846779 0.5616217373225454 1.0 0.7970127603446912 164 P15586,Q14108,Q96NT0,P09601,O75251,Q9NZJ7,Q6PGP7,P14174,Q9BUB7,P00813,O43772,P07602,P09622,P36551,Q96CU9,O15118,Q9Y6M9,Q05655,Q86Y39,O14617,P08236,P40939,P35573,P31751,Q9BU61,P61916,P00846,P49327,Q9HC07,P50542,Q15067,P16278,Q14739,Q9Y619,Q10713 35 +Abnormal eosinophil morphology 0.4160539968112151 0.5793611531731708 0.5623455102667978 1.0 0.7976000621292636 10 Q05655,P49327,P00813,Q9Y6K9 4 +Polycystic kidney dysplasia 0.3676030147759866 0.5787482135053459 0.5627590786939995 1.0 0.7979393752114113 17 P49815,Q6PGP7,P50542 3 +Abnormality of the testis size 0.3286178788003459 0.5756690861428917 0.564838874469789 1.0 0.7998971313268021 27 P27635,O43175,Q9H7N4,Q9UPW6,Q9BZH6,O75312,P38398,Q8IWS0,Q8NI27,P09884,O60828,P38159,P19447,O15294 14 +Renal cortical cysts 0.4291134768565665 0.5725482731471259 0.5669505918289237 1.0 0.8021689458468025 5 Q6PGP7 1 +Optic disc pallor 0.2972812090768397 0.5725333871581478 0.5669606735861934 1.0 0.8021689458468025 49 Q9Y6M9,O95831,P04439,P00846,Q86Y39,Q8IYI6,Q8ND04,O95298,O75251,Q9H061,Q96CU9,Q10713,Q9BUK6 13 +Deep palmar crease 0.3813225914829176 0.5713989135539389 0.5677292653868595 1.0 0.8022199625357274 13 O00170,P98175,Q69YQ0 3 +Retinal dysplasia 0.4410146206677268 0.5701497087351426 0.5685761626813277 1.0 0.8022199625357274 8 O43924 1 +Emg abnormality 0.2786604463796961 0.5692115292380541 0.5692125974389419 1.0 0.8022199625357274 74 Q9NR77,O95425,P06753,P07602,O43681,O15269,P49773,P09493 8 +Uterus didelphys 0.3558424362793755 0.5691573009084689 0.5692493948192756 1.0 0.8022199625357274 3 Q96EX3,Q8NCM8 2 +Abnormality of the amniotic fluid 0.2631536859936587 0.5689754124264096 0.5693728260482571 1.0 0.8022199625357274 82 Q9BV10,Q9BUB7,Q7LGA3,Q15125,Q92766,Q9NPF4,P06753,P40939,Q9UBM7,Q14739,Q9UHX1,Q6PGP7,Q9BTW9,Q70HW3,O75844 15 +Abnormal leukocyte physiology 0.282696774205905 0.5688488188765463 0.569458741157653 1.0 0.8022199625357274 63 Q9Y6K9,P14174,Q14108,P00813,P09601,O60220 6 +Abnormal bleeding 0.2669211942915289 0.5674316316598776 0.5704209642088274 1.0 0.8033282317488625 101 O15484,Q14108,Q92947,P35579,Q13126,P49815,P21333,Q9Y6K9,O00170,Q01130,P05067,Q05655,Q9Y487,Q9NZ08,Q8NCH0,Q9UHX1,O75844,P49327,P49257,Q92766,Q14739 21 +Spinal canal stenosis 0.4638538232244927 0.5663563919272552 0.5711515328030461 1.0 0.8036192875158524 6 Q8IWS0,O00170,Q15813 3 +Abnormal clavicle morphology 0.3507277621536248 0.5649981131529956 0.5720750475684817 1.0 0.8043001112327305 20 O75531,Q14739,O75844 3 +Abnormality of the posterior pituitary 0.4395069696890041 0.5635870436398697 0.5730352064281394 1.0 0.8048004577490235 8 Q9BZH6 1 +Muscle weakness 0.2358754117141102 0.5630361170747499 0.573410290500973 1.0 0.8048141366522397 269 P00403,Q9NR77,P35270,O43681,O15269,Q7RTS9,Q9UHD1,P49773,Q9NZJ7,Q13126,Q15043,Q70HW3,O95831,Q5KU26,Q15165,O43772,P06753,P07602,P41440,P51970,Q9BZH6,Q86Y39,Q8IYI6,O95425,Q99720,P40939,Q9Y6X9,P00846,Q9HC07,P50542,Q15067,Q14739,Q10713 33 +Multiple prenatal fractures 0.4625675892110961 0.5612005682960826 0.5746608155901838 1.0 0.8058170875291172 6 P06753,Q14739 2 +Abnormality of hepatobiliary system physiology 0.2610364607435596 0.560453777935605 0.5751699589242172 1.0 0.8058170875291172 80 P00846,Q8N511,P50542,O43772,P40939,P09622,P55263,P22830,Q9Y619,Q10713,O15118 11 +Long foot 0.4120868614262766 0.5604293042275786 0.5751866481055714 1.0 0.8058170875291172 10 P21333,O75530,O00170,Q15022 4 +Abnormal saccadic eye movements 0.3444500024232088 0.5599209889129467 0.5755333316872808 1.0 0.8058170875291172 21 O15020,Q8IV08,P34897,Q9BU61,Q9UHD1,Q10713 6 +Aplasia hypoplasia of the nipples 0.3641492476509945 0.5583802657017829 0.5765847455467019 1.0 0.8060563165446716 17 Q9Y6K9,P10586 2 +Abnormal urinary color 0.4614029242390556 0.5565432127419523 0.577839562101506 1.0 0.8068576914510246 6 P49815 1 +Abnormality of facial skeleton 0.235411583745054 0.5526764644384612 0.5804849722044281 1.0 0.8087694734628997 313 O96028,P46777,Q15125,Q9NPF4,Q5SRE5,Q7RTS9,Q9Y3B2,P35250,Q8N201,Q00535,Q15043,Q07020,Q13057,O95831,O00170,P98175,Q9UPW6,Q9BUB7,P00813,P61586,Q15392,Q7LGA3,O75530,Q2TAA5,P06753,Q14807,Q08J23,Q9BTW9,Q00839,Q9BV10,Q9BUK6,Q05655,O43924,Q9Y487,Q8ND04,O95425,O14617,P35573,P09884,O60828,O15111,Q8NCH0,Q9UHX1,O75844,Q86XL3,Q9Y4W2,Q9HC07,Q01968,Q86XI2,O75531,P50542,P28340,P61313,Q9H7D7,Q92766,Q9UIG0,Q13045,Q9H9E3,P16278,Q6PJG6,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 66 +Limb undergrowth 0.2830802824293822 0.550707030619849 0.5818345242813332 1.0 0.8093077734714352 54 Q03164,P98175,O75718,Q15392,Q15125,Q14739,O00116,Q7RTS9,O15111,Q9UBM7,Q9UHX1,Q6DKJ4,Q9BV10 13 +Aplasia hypoplasia of the extremities 0.2502922987619269 0.5435646491994269 0.5867410917009641 1.0 0.8137921141561554 177 O96028,Q15125,Q7RTS9,P49773,O95831,Q9Y6K9,P98175,Q13555,P00813,Q7LGA3,Q15392,Q08J23,Q9BV10,O75844,Q9Y4W2,P50542,O00116,Q14739,Q9Y619,Q9UGU0,Q6DKJ4,Q69YQ0 22 +Glomerulonephritis 0.3523290330661282 0.5429858448050119 0.5871395485574249 1.0 0.8140980653581744 19 P49327,Q05655,Q92621,Q8NFH4,Q8N1F7,Q14C86 6 +Increased hepatic glycogen content 0.3871787893649473 0.5416286568266635 0.5880743463032085 1.0 0.8149004792702953 4 P31751 1 +Abnormality on pulmonary function testing 0.3559464373165885 0.5361855781980577 0.5918302997087284 1.0 0.8173830059646499 18 P49815,P16278 2 +Acute phase response 0.3311115960922401 0.5350843239506955 0.592591549271763 1.0 0.8181874874862322 24 Q05655,Q01968,P14174,P36551,P41440 5 +Periventricular white matter hyperintensities 0.4062943394569212 0.5330856500341988 0.5939742920686617 1.0 0.8189423312896792 10 P07602,O43681,Q9NZJ7 3 +Potter facies 0.3130377233620197 0.5327425373892417 0.5942118160832477 1.0 0.8189423312896792 2 Q53EZ4 1 +Hallucinations 0.2948977566571681 0.5311557407710095 0.5953108602989867 1.0 0.8199632282842197 48 Q9BQE5,P15289,P11182,P50897,P07602,O43681,P50336,P36551,Q709C8,Q99497,O75503,Q9NZJ7,P05067 13 +Abnormal electroretinogram 0.3108041645187024 0.5294605493271338 0.5964860045156297 1.0 0.8208407825219596 32 P00846,O43924,P50897,P40939,O60220 5 +Facial cleft 0.4533780900020386 0.524752171595107 0.599755484155827 1.0 0.8248440057034916 6 Q69YQ0 1 +Poikiloderma 0.3831125827814462 0.5232335788479134 0.6008117167205815 1.0 0.8250570739364242 4 P19447,P18074,O75431 3 +Abnormal blood monovalent inorganic cation concentration 0.33859221009343 0.522045340623669 0.6016387621343942 1.0 0.8256973356189271 21 Q01968,O00170,P05023,Q13423,P36551,Q9BV10 6 +Head tremor 0.3711466751849894 0.517138729319519 0.6050593195167748 1.0 0.8284731385705434 13 Q99720 1 +Abnormality of the autonomic nervous system 0.2775338497218889 0.5163410727725966 0.6056162144975346 1.0 0.8284731385705434 57 P06280,P15289,P42892,Q92766,Q15067,P07602,O43681,P50336,O15269,Q709C8,Q6PJG6,P41440,Q9NZJ7,Q9UBM7,Q10713 15 +Ankle flexion contracture 0.3645606888317262 0.5161272245751515 0.6057655545897964 1.0 0.8284731385705434 15 P06753 1 +Severe intrauterine growth retardation 0.3449189010261453 0.5151048139220404 0.6064797789757468 1.0 0.8291093035758641 3 O14802,Q15813 2 +Decreased circulating antibody level 0.2996725896866739 0.5131451121463083 0.6078498171409348 1.0 0.8300775909908019 44 Q9Y6K9,P14174,P00813,P09601,O60220 5 +Biparietal narrowing 0.4010672406487902 0.5087353926916414 0.6109377106605656 1.0 0.8305936452416246 10 Q10713,Q00839,O43924 3 +Abnormality of pancreas physiology 0.3014244536849632 0.5053376434665358 0.6133217076692394 1.0 0.8320922546070287 42 Q9NZ08,P11182,P14174,Q14739 4 +Slurred speech 0.4256794553588504 0.5043879767367897 0.6139887653386717 1.0 0.8323428599621384 8 P16278,Q9Y487,O15020,Q8N0X7 4 +Secondary amenorrhea 0.3547887230259851 0.5040916034568979 0.6141970070548943 1.0 0.8323428599621384 17 Q9BZH6,P29401,O60879,P49770,Q12830,Q13144 6 +Nonprogressive cerebellar ataxia 0.3426017874875836 0.5038511100712004 0.6143660085680063 1.0 0.8323428599621384 3 Q4G0N4,O75027 2 +Emotional lability 0.2899000384036121 0.5032510308072724 0.6147877905494656 1.0 0.8323428599621384 49 P07737,Q9Y4W2,O00170,Q9UPW6,P15289,Q15165,P49770,Q96CU9,P07602,O43681,Q92804,O75251,Q9NZJ7 13 +Multiple suture craniosynostosis 0.411718832449642 0.4991208277436135 0.6176942655909574 1.0 0.8352102374031941 5 Q92766 1 +Tricuspid atresia 0.411718832449642 0.4991208277436135 0.6176942655909574 1.0 0.8352102374031941 5 Q92766 1 +Infantile axial hypotonia 0.3988775520366578 0.4986311810406295 0.6180392344408205 1.0 0.8354298806956986 10 P07602,Q15043 2 +Decreased activity of mitochondrial complex i 0.3066610024231566 0.4979750979443812 0.6185015941024035 1.0 0.8354892405296982 33 Q9Y6M9,Q86Y39,Q96CU9,O95298,O75251,P51970,Q9Y584,Q9UBX3,Q70HW3 9 +Abnormal tissue metabolite concentration 0.3535726904995705 0.4971439028639346 0.6190875768912787 1.0 0.8356130461313426 17 P50542,P06280,Q96NT0,P07602,O43681,Q9NZJ7 6 +Recurrent lower respiratory tract infections 0.3180508452408098 0.4947728637217374 0.6207604614673328 1.0 0.837377138855285 29 Q05655,P11047,P00813,P78527,P78318,O95298,P09884,Q9BTW9,Q9BV10 9 +Limb hypertonia 0.3030603174293061 0.493277593754521 0.6218164579814309 1.0 0.8383074898913135 39 Q8WVX9,Q2TAA5,P31040,Q15125,Q9Y263,P54136,P42695,P35270,O95298,Q96F07,Q14739,Q9H9E3,P62873 13 +Abnormal eyebrow morphology 0.2508390300250506 0.4913794458006248 0.6231580989895056 1.0 0.8391102854008398 154 P15586,O96028,Q15125,Q5SRE5,Q8N201,O95831,O00170,P98175,Q13555,P00813,Q7LGA3,Q5KU26,Q08J23,Q00839,P48449,O43924,P09884,O60828,Q9UHX1,O75844,Q9Y4W2,O75531,Q9UGU0,Q10713,Q69YQ0 25 +Premature rupture of membranes 0.4445116524679747 0.4902739929841694 0.6239400276372808 1.0 0.8391158570234974 6 O75844 1 +Absent epiphyses 0.4444450804169245 0.4900178372650948 0.624121276799849 1.0 0.8391158570234974 6 Q7LGA3,Q7RTS9 2 +Abnormality of circulating enzyme level 0.2619796134127959 0.4881879546940893 0.6254167156468378 1.0 0.8391158570234974 95 Q96NT0,P49773,P35250,Q9Y584,O95831,Q5JRX3,O43772,P06753,Q08J23,P09493,Q9BUK6,Q9BTW9,O95425,P40939,P35573,P53985,P13473,Q9HC07,Q9UIG0 19 +Respiratory tract infection 0.2505888430474564 0.4880093454102074 0.625543221572312 1.0 0.8391158570234974 155 P15586,O96028,P17812,P43034,Q92621,P29144,P09601,O60220,O95298,Q7RTS9,Q14C86,Q9NZJ7,P35250,P49815,P21333,P14174,Q9Y4I1,P00813,P78318,P06753,P07602,Q9BTW9,Q9BV10,Q05655,P11047,P33991,Q9Y487,O14617,P78527,P08236,Q8N1F7,P09884,Q01968,P50542,O00462,Q8NFH4,P53634,P49792,Q07864,P16278,Q9H9E3,Q9UIG0,Q6DKJ4 43 +Sparse lateral eyebrow 0.4216609787264702 0.4875438390871356 0.6258729836172863 1.0 0.8391158570234974 8 Q9H7D7,P62140,Q08J23,O60828 4 +Aplasia hypoplasia involving the skeleton 0.2332115946651291 0.4869890901111449 0.6262660623972618 1.0 0.8391158570234974 296 Q03164,O96028,Q15125,Q9NPF4,Q7RTS9,P49773,P35250,Q8N201,Q00535,Q07020,Q13057,O95831,Q9Y6K9,P98175,Q13555,Q9UPW6,Q9BUB7,P00813,Q7LGA3,Q15392,O75530,Q14807,P06753,Q08J23,Q9BTW9,Q00839,Q9BV10,Q9BUK6,O43924,O75718,Q8ND04,P08236,O15111,O60828,Q8NCH0,Q9UHX1,O75844,Q86XL3,Q9Y4W2,Q01968,Q86XI2,O75531,P50542,P28340,P61313,Q9H7D7,Q92766,Q9UIG0,Q13045,Q8IWS0,Q9H9E3,P16278,Q6PJG6,O00116,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 60 +Abnormality of the external nose 0.2296786720060629 0.4860690498881099 0.6269182098835011 1.0 0.8394200316178415 216 P15586,O96028,Q15125,Q5SRE5,Q9Y3B2,Q8N201,Q6PGP7,O95831,P98175,Q9UPW6,Q9BUB7,Q7LGA3,P61586,Q15392,Q5KU26,Q08J23,O43924,Q9Y487,Q8ND04,P42892,Q96KP1,O60828,Q9UHX1,O75844,Q9Y4W2,O75531,P50542,Q9H7D7,P16278,Q10713,Q9UGU0,P10586,Q6DKJ4 33 +Spasticity 0.2331536247273528 0.4856527199037041 0.6272134108656153 1.0 0.8394200316178415 296 P26358,Q9NPF4,P35270,O43681,O60220,O95298,Q7RTS9,O75251,Q9UHD1,Q9NZJ7,P35250,Q15043,Q13057,P07737,O95831,Q9Y6K9,Q9UPW6,Q9Y4I1,Q2TAA5,Q5KU26,Q15392,Q15165,O75530,P07602,P09622,Q08J23,P51970,O15118,Q8IYI6,Q9Y487,Q99720,P50897,Q96KP1,P09884,O60828,Q96N66,P61916,Q9UBX3,Q9NZ01,Q9Y6X9,P00846,Q86XL3,P50542,Q9H7D7,Q9UIG0,P16278,O75503,Q9Y619,Q9UGU0,Q10713 50 +Parkinsonism with favorable response to dopaminergic medication 0.395777104349518 0.4844257011522206 0.6280837820840364 1.0 0.8400758242544227 10 P07602,P31930 2 +Abnormal respiratory system morphology 0.2329873691132441 0.4831484052401423 0.6289903665395735 1.0 0.8410426256650974 300 P17812,P43034,P46777,Q14108,Q9H9Y6,P21333,P14174,P06280,P00813,Q15392,Q15165,P78318,P07602,Q86TI2,P11047,P33991,Q92804,Q9NZ08,Q8N1F7,O75844,O00462,P55072,P16278,Q07864,P49792,Q14739,Q96HY6,P15586,P29144,P09601,P60953,O60220,Q7RTS9,Q14C86,Q27J81,P49815,Q92890,Q9Y4I1,Q7LGA3,P06753,Q9BV10,Q8ND04,P78527,P09884,P50542,Q8NFH4,P53634,Q9UGU0,Q6DKJ4,Q69YQ0,O96028,Q15125,O95298,Q9NZJ7,Q6PGP7,P07737,P98175,Q9UPW6,Q9Y487,O15111,Q9UHX1,Q9H7D7,Q92766,Q9UIG0,Q92621,P35250,Q8IZA0,Q14807,Q9BTW9,Q05655,O75718,O14617,P08236,Q8NCH0,P49327,Q01968,Q13045,Q9H9E3,Q9UBM7 79 +Ichthyosis 0.3035566944498911 0.4811751511107446 0.6303920199608373 1.0 0.8421821289477501 36 P48449,Q15800,Q9BZH6,P50542 4 +Abnormality of the synovia 0.2576245011547391 0.4796933838746365 0.6314454330864008 1.0 0.8421821289477501 79 O96028,Q01968,P43034,Q9Y487,O75718,Q14807,Q9NPF4,P08236,P06753,P16278,Q7RTS9,Q9UBM7,Q9Y584,Q9UHX1,Q9BTW9,O75844 16 +Hyperkinetic movements 0.3809862368470607 0.4794817146731476 0.6315959734466876 1.0 0.8421821289477501 11 P07602 1 +Pancreatitis 0.3314780431022996 0.4769267279080005 0.6334142986193068 1.0 0.8427724548780718 21 Q9NZ08,P11182 2 +Peritonitis 0.3571324303617184 0.4757515125813736 0.634251417247462 1.0 0.8431749980716449 15 P52565,Q92621,Q8NFH4,Q8N1F7,Q14C86,Q27J81 6 +Dental crowding 0.3160351793556198 0.469455116020374 0.6387443601118148 1.0 0.8472205330403527 26 Q01968,Q69YQ0,P28340,Q9UPW6,O75531,P06753,Q9UBM7,O75844 8 +Ventricular arrhythmia 0.3012157162855328 0.4668342803033248 0.6406184477303691 1.0 0.8476758124492337 37 P49815,P00846,P00403,P42892,O43772,P09493 6 +Bone pain 0.3395206037240055 0.4658931403672885 0.6412919914459234 1.0 0.8481518499217383 19 Q14108 1 +Physical urticaria 0.3001323626737343 0.4645805695114331 0.6422318495435841 1.0 0.8489865732320439 2 Q9Y5L0 1 +Kyphosis 0.2489632360686315 0.4614452182948197 0.6444792159715904 1.0 0.8504891896134753 145 O96028,Q14108,Q9NR77,Q15125,Q7RTS9,P35250,O95831,Q9Y6K9,O00170,Q7LGA3,Q5KU26,Q14807,P06753,Q9Y487,O95425,P08236,Q8NCH0,Q9UHX1,O75844,Q01968,Q9HC07,P28340,Q9UIG0,Q8IWS0,P16278,Q14739,Q9UGU0,Q9UBM7,Q6DKJ4 29 +Abnormal myelination 0.2358024582636306 0.4612729403700032 0.6446027963227323 1.0 0.8504891896134753 203 P00403,P26358,Q9NR77,O43681,O15269,Q5SRE5,Q9Y3B2,Q9Y584,Q9NZJ7,O95831,Q9UPW6,Q7LGA3,Q5KU26,Q2TAA5,P07602,P41440,Q9BV10,Q86Y39,Q8IYI6,P78527,Q99720,Q96KP1,Q9Y6X9,P00846,Q15067,Q6PJG6 26 +Abnormal pulmonary interstitial morphology 0.3092125637221411 0.4570030669982168 0.6476688410426816 1.0 0.852568388108241 30 Q05655,P14174,Q8IZA0,Q14108,O14617,P09601 6 +Abnormality of the spinal cord 0.2716071085091799 0.4567269583684238 0.6478673114880924 1.0 0.8525844406788381 66 O96028,Q9Y6K9,Q92766,Q9UIG0,Q08J23,P16278,P09884,P35250,Q9UHX1,P05067,Q10713,Q9Y6X9 12 +Abnormality of the optic nerve 0.228675606940563 0.4563895335171103 0.6481098908082616 1.0 0.85265851400673 244 O96028,P00403,P26358,Q15125,O43681,O60220,O95298,Q9NZJ7,Q15043,P49815,O95831,Q9Y6K9,P98175,Q9Y4I1,Q7LGA3,P61586,Q5KU26,P07602,P41440,Q00839,Q9BZH6,Q86Y39,Q8IYI6,Q8ND04,P50897,Q9NZ08,Q96KP1,Q9H061,P00846,P50542,Q15067,P16278,Q6PJG6,Q9UGU0,Q10713 35 +Skeletal muscle hypertrophy 0.2976060073724947 0.4558940301665131 0.6484661826205358 1.0 0.8528821028316645 40 O00170,Q7LGA3,Q9NR77,P16278,O60828,Q9UIG0,Q10713 7 +Abnormality of epiphysis morphology 0.271621528795308 0.4543000123159015 0.649612907207092 1.0 0.8541448653510084 58 O96028,O95831,Q9HC07,P50542,Q7LGA3,P16278,O00116,Q7RTS9,Q14739,Q9Y619 10 +Excessive salivation 0.3116524890821357 0.4535681904828976 0.650139652771637 1.0 0.854319435563284 27 P15586,Q9NR77 2 +Decreased fertility 0.327513236026305 0.4522397700273533 0.651096260556493 1.0 0.8546221923048661 21 Q9BZH6 1 +Chorea 0.2610411742245768 0.4503740367247078 0.6524407626299766 1.0 0.8553052742884226 77 P00846,Q9BWD1,Q99720,P35270,P07602,O43681 6 +Abnormality of the tongue 0.258392362388096 0.4495386182562166 0.653043156219592 1.0 0.8557052751265595 89 Q9H9Y6,P35250,O95831,O00170,P98175,Q7LGA3,Q9BTW9,Q05655,O43924,O15111,O60828,Q9Y6X9,O75844,P49327,P50542,P16278,Q9UIG0,Q9UBM7,Q10713,Q6DKJ4 20 +Abnormality of the upper respiratory tract 0.2589993827673738 0.4489681976858857 0.6534545982991067 1.0 0.8559993407026363 91 P07737,P15586,Q69YQ0,Q05655,Q9UPW6,P00813,Q14807,Q15165,Q92766,P08236,P07602,Q9H9E3,P16278,Q7RTS9,Q14739,Q9NZJ7,Q9UHX1,Q9BV10 18 +Acantholysis 0.399138787678057 0.4479926546610607 0.6541584977593782 1.0 0.8566756079123217 5 P14923,P98194,P01889,P15924 4 +Calvarial skull defect 0.4111638651930464 0.4443882279474261 0.6567619230347101 1.0 0.8581982328260792 8 Q14739 1 +Chronic oral candidiasis 0.3300231711353776 0.4442005043109462 0.6568976276757319 1.0 0.8581982328260792 3 P02786,O75083 2 +Dysmetric saccades 0.4323101286959656 0.4440488370130472 0.657007275603632 1.0 0.8581982328260792 6 P13639,O15020,O14773 3 +Somatic mutation 0.2951881525170366 0.4440475353171874 0.6570082166970901 1.0 0.8581982328260792 41 P49815,O00170,P11717,P00813,P61586,Q9BZE9,O14965 7 +Vertebral hypoplasia 0.386380818724623 0.442141492261511 0.6583868209082775 1.0 0.8587124051567451 10 P16278 1 +Constriction of peripheral visual field 0.3258578914094309 0.4420361756269218 0.6584630283225714 1.0 0.8587124051567451 21 Q9H061,O60220,P00846 3 +Premature loss of teeth 0.3729959857631406 0.4417332126737392 0.6586822729516422 1.0 0.8587124051567451 11 O75844 1 +Congenital hip dislocation 0.3231395817289727 0.4414285633889362 0.658902767513762 1.0 0.8587124051567451 22 P43034,Q9Y487,Q14807,P06753,Q9UHX1,Q9BTW9 6 +Abnormality of the zygomatic bone 0.2673502939753992 0.440111098039551 0.6598566443370322 1.0 0.8588438827696477 74 O95831,Q9Y4W2,Q9HC07,Q9UPW6,O75531,Q9Y487,P61586,Q14807,Q15125,Q92766,Q9UIG0,P35573,Q9H9E3,Q14739,O60828,Q9H9Y6,P35250 17 +Abnormal pulmonary valve morphology 0.3504247885562659 0.4400976044510981 0.6598664168864019 1.0 0.8588438827696477 15 Q9BUB7,P09884,Q6DKJ4 3 +Retinal arteriolar tortuosity 0.3584525988486182 0.4394753268086578 0.6603171560992769 1.0 0.8588438827696477 12 P00846,Q9UIG0,Q92766 3 +Skin rash 0.3295318768199644 0.4344030399135613 0.6639957906416671 1.0 0.8628928829548298 20 P14174,Q14739 2 +Abnormal tracheal morphology 0.2965554750773605 0.4301525712339809 0.6670846603662199 1.0 0.863718950635414 37 P46777,Q9H7D7,Q14807,Q15125,Q9UIG0,Q14739,P35250,Q9UBM7,Q69YQ0 9 +Tented upper lip vermilion 0.3153418601363799 0.4295076141760913 0.667553853938136 1.0 0.8640820105980906 24 Q86XI2,Q13045,P60953,Q6PJG6,Q96F07,Q9UGU0,Q10471,Q6DKJ4 8 +Functional abnormality of the inner ear 0.2248881397973937 0.4279700477816818 0.6686729272889256 1.0 0.8647968319303229 228 O96028,P00403,P26358,Q9NR77,Q15125,O43681,O60220,O15269,Q9NZJ7,Q15043,O95831,O00170,Q7LGA3,P07602,P55263,P41440,P09493,Q9BV10,Q9BZH6,Q86Y39,P42892,P78527,Q9NZ08,Q9H061,O75844,P00846,P50542,Q15067 28 +Focal myoclonic seizure 0.4174885846447069 0.426523834523232 0.6697261842134119 1.0 0.8657708680223183 7 P31040,O75503,O14617,Q9H936 4 +Spinal muscular atrophy 0.3696940668643751 0.4264165015950373 0.6698043792149944 1.0 0.8657708680223183 11 Q99720 1 +Retinal vascular tortuosity 0.3531188832988197 0.4248207079144951 0.6709673807343441 1.0 0.8664363683935687 13 P00846,Q9UIG0,Q92766 3 +Hypersplenism 0.3824392148985673 0.4247685122944001 0.6710054338133875 1.0 0.8664363683935687 10 Q05655,P49327,Q14108,P07602,Q9NZJ7 5 +Short digit 0.2462049270062674 0.4239263242297259 0.6716195453709306 1.0 0.8664363683935687 140 P48449,O95831,Q69YQ0,Q13555,O43924,P00813,P61586,Q7LGA3,Q08J23,Q7RTS9,Q14739,Q9UGU0,Q6DKJ4,O75844 14 +Inverted nipples 0.3944240574960519 0.4233911625662425 0.6720098916140465 1.0 0.8664363683935687 9 Q9BV10,Q9UGU0,Q15067 3 +Abnormal circulating aspartate family amino acid concentration 0.4059337225803048 0.4233732420559024 0.6720229643428379 1.0 0.8664363683935687 8 P55263 1 +Abnormal tongue morphology 0.2679451854136556 0.4212142925161583 0.6735986086208594 1.0 0.8677345431065785 67 O00170,P98175,O43924,Q7LGA3,Q9UIG0,P16278,Q6DKJ4,O15111,O60828,Q9H9Y6,P35250,Q9UBM7,Q10713,O75844,Q9Y6X9 15 +Red eye 0.3316474820913214 0.4201025353670022 0.6744105506251077 1.0 0.8685360411398756 19 Q9NZ08 1 +Vertebral segmentation defect 0.3040371645671549 0.4197437742126187 0.6746726431982406 1.0 0.8686291667843453 30 O96028,Q9Y6K9,Q15125,Q9Y619,Q9UIG0,Q9UHX1,Q6DKJ4 7 +Oligosacchariduria 0.3917064757293638 0.4186698816310796 0.6754574100569042 1.0 0.8686353394188856 5 P16278,Q01968,O00462 3 +Abnormal globus pallidus morphology 0.4046957822109845 0.4184491862189794 0.6756187310504862 1.0 0.8686353394188856 8 Q13057,Q9BU61 2 +Sparse hair 0.2524361537020942 0.4172686917635455 0.6764818859915493 1.0 0.8694741932464415 79 P48449,Q9Y6K9,Q9BZH6,O75531,Q9UPW6,Q15125,P53634,Q08J23,O60828,Q6PGP7,O75844 11 +Immunologic hypersensitivity 0.2959840743903606 0.4164372985195033 0.6770900400980957 1.0 0.8697842025060298 33 Q01082,Q92890,P49327,Q9UPW6,P50542,P00813,Q8TD19,Q92766,Q01130,Q9NZ08,Q08J23,Q9Y5S9,Q93009 13 +Minimal change glomerulonephritis 0.3485418388884602 0.4150669803645212 0.6780928707014156 1.0 0.8705837501263335 14 Q92621,Q8N1F7,Q8NFH4,Q14C86 4 +Abnormality of primary teeth 0.3482606417916065 0.4136491561315518 0.6791310678935547 1.0 0.8713396528632212 14 P61586,O75844 2 +Cardiac conduction abnormality 0.2993837849027265 0.412975186853956 0.6796247933881485 1.0 0.8713396528632212 31 P00846,O43772,O75531 3 +Neoplasm 0.228294638656731 0.4098903373894408 0.6818863938221862 1.0 0.8731685498799631 212 O96028,P11717,P17812,P63167,P46777,O43681,Q92947,O14965,Q9H9Y6,Q9NYB0,Q9NZJ7,Q6PGP7,Q13126,Q07020,P49815,P21333,Q9Y6K9,O00170,P15289,P00813,Q7LGA3,Q15392,Q01130,P07602,P50336,Q08J23,P36551,Q9BUK6,Q9H4L7,Q05655,O43924,P33991,P42892,Q9BZE9,Q92804,P10619,Q9UHX1,Q9H488,P49327,Q01968,P28340,P61313,Q06136,Q13423,P53634,Q9UBM7,Q10713 47 +Abnormal circulating bilirubin concentration 0.3089203633178365 0.4089365744799915 0.6825862074438513 1.0 0.8731685498799631 25 P43034,P36551,Q14739,P55263,P41440,P00390 6 +Cirrhosis 0.2937571709097878 0.4084905737284858 0.682913549571095 1.0 0.87326400981719 37 P11717,Q14108,P22830,Q14739,Q10713 5 +Metaphyseal irregularity 0.3518668231303459 0.4074879002144866 0.6836496791998128 1.0 0.8735932499261033 12 Q14807,Q96HY6,Q7RTS9,P50542 4 +Finger clinodactyly 0.2508719255592264 0.4066098375343373 0.6842945707803691 1.0 0.8735932499261033 83 Q03164,Q15125,Q7RTS9,P35250,Q9UPW6,Q08J23,Q9BV10,O43924,P09884,O60828,Q9UHX1,Q8NFH4,Q9UIG0,Q13045,Q6PJG6,Q9Y619,Q9UGU0,Q6DKJ4,Q69YQ0 19 +Elbow flexion contracture 0.3048928588066172 0.4038340488550589 0.6863347565820717 1.0 0.8740291588824064 28 P21333,O00443,Q7LGA3,Q14807,O95425,P06753,Q8WXH0 7 +Bulbar palsy 0.3773201914150133 0.4025489084777487 0.6872801017708228 1.0 0.8742859993899543 10 P15289,Q9Y263,P55072,P06753,O43681 5 +Phenotypic variability 0.2551784578342091 0.4011563658748914 0.6883050038704441 1.0 0.8747266635434526 93 P00846,P00403,Q9UEY8,Q9H7D7,Q9NR77,Q15125,Q9BUF5,P35270,P07602,P09622,P06753,P36551,Q9H061,Q9NZJ7,Q70HW3 15 +Myopathic facies 0.4204415903307341 0.4005881196723147 0.6887233939234565 1.0 0.874906182067072 6 P06753 1 +Prolonged neonatal jaundice 0.332110663277963 0.399326842513288 0.6896523911033661 1.0 0.8758432281021383 18 P61916,Q96NT0,O15118 3 +Aortic regurgitation 0.3071663685231065 0.3974511941166701 0.6910347702447428 1.0 0.8769265082433646 25 P49327,Q9NZ08,Q9UHX1,Q6PGP7,O75844 5 +Chronic noninfectious lymphadenopathy 0.3536353565575191 0.3962488010371147 0.6919214933106144 1.0 0.8775075297541374 4 Q05655 1 +Resting tremor 0.3310929475290954 0.3937425105775665 0.6937711524956458 1.0 0.8779072615351315 18 P26358,P07602,Q709C8,P31930,Q99497,Q9NZJ7 6 +Ureteral stenosis 0.3851400921916974 0.3933571140869478 0.6940557399391429 1.0 0.8780246328638632 5 P21333,Q9UBM7 2 +Difficulty standing 0.3842232639256788 0.3898691512062889 0.6966333062395369 1.0 0.8796072944833937 5 P52788,Q7RTS9 2 +Supernumerary spleens 0.407645643808949 0.389427967044116 0.6969595869318401 1.0 0.8796072944833937 7 Q96KP1 1 +Irregular hyperpigmentation 0.2649955541170758 0.3883213320299712 0.697778252802826 1.0 0.8796072944833937 66 P49815,Q9Y6K9,O75531,Q7LGA3,P09884,Q14739,Q9UGU0,O75844 8 +Oval face 0.4169889147077654 0.388246190626351 0.6978338536382935 1.0 0.8796072944833937 6 Q96KP1 1 +Abnormal sacrum morphology 0.2959191024500821 0.38807924941889 0.697957387486994 1.0 0.8796072944833937 31 Q03164,O96028,Q86XI2,Q15125,Q9UIG0,Q08J23,Q14739,P35250,Q6DKJ4 9 +Obstructive sleep apnea 0.3610282547598035 0.3870632793521568 0.6987093617015039 1.0 0.8796072944833937 11 Q96KP1 1 +Aplasia hypoplasia of the thymus 0.3370160323548128 0.3869867316804953 0.698766030749753 1.0 0.8796072944833937 16 Q92890,P50542,P00813,Q92766,Q9H9Y6,Q6PGP7 6 +Muscle fiber atrophy 0.3212928549174106 0.3862097152620958 0.6993413591527502 1.0 0.8800894695744124 20 Q99720 1 +Aspiration 0.3842224289010369 0.3815847454178201 0.7027694009600796 1.0 0.8825535341220926 9 Q9H2P0,P43243,Q69YQ0 3 +Hypogonadotropic hypogonadism 0.3104500812863245 0.3796929779116401 0.7041733333215463 1.0 0.882772212164535 23 P00403,O00170,Q9Y4W2,Q9BZH6,Q9UIG0 5 +Lipodystrophy 0.2908093051124555 0.3789124979364377 0.7047528430355561 1.0 0.8828154062483056 34 Q9Y487,O75531,P09493,O75844 4 +Increased serum lactate 0.2526638286652007 0.3786959814375237 0.7049136378442005 1.0 0.8828154062483056 101 P00403,O14949,Q9BWD1,Q99797,O95298,O75251,Q9Y584,Q70HW3,O95831,Q9BUB7,Q5JRX3,P09622,Q6P4A7,P51970,Q96CU9,Q9Y6M9,Q86Y39,P22695,Q9BU61,Q9UBX3,P00846 21 +Fatigable weakness of skeletal muscles 0.3944136933720337 0.3783304357962225 0.7051851382578738 1.0 0.8828154062483056 8 P49773 1 +Areflexia 0.2484793988203792 0.3780882007313888 0.7053650733340733 1.0 0.8828154062483056 83 O95831,P50542,Q9NR77,Q15067,P06753,P40939,O15269,P41440,P49773,Q9Y6X9 10 +Hyperlipidemia 0.294421123421072 0.3774408305395067 0.7058460284325396 1.0 0.8829735115918057 31 P49257,P28340,Q9Y4I1,Q13045,P35573,P31751,P22830,O75844 8 +Renal agenesis 0.262737640373589 0.3767668199706864 0.7063469005305698 1.0 0.8829735115918057 55 Q86XL3,Q9BZH6,O43924,P61313,Q7LGA3,Q15392,P42695,Q9BU61,Q9UBM7,Q9UHX1,Q07020 11 +Abnormality of skeletal maturation 0.2529876343772204 0.3760159049011499 0.7069050718581162 1.0 0.8829735115918057 90 P48449,Q9UHD1,O95831,O96028,Q9BZH6,Q14108,O75530,Q08J23,Q15800,P09884,Q9Y619 11 +Bladder neoplasm 0.4133839193460736 0.3755123258916016 0.7072794812852403 1.0 0.8829735115918057 6 O14965 1 +Scrotal hypoplasia 0.3235185604822431 0.3742804011323912 0.7081957118318822 1.0 0.8834591913476493 19 P46977,P07437,Q9H0U9,Q8IWS0,Q9H9Y6,Q9UBM7,Q9BV10 7 +Punctate cataract 0.3476733185679304 0.3721261924722379 0.7097988957097008 1.0 0.8842524833103141 4 P08670 1 +Abnormal patella morphology 0.3013609077918014 0.3707055966301669 0.7108568213865039 1.0 0.8846433689818269 26 Q92890,P21333,Q01968,Q9Y2D4,Q14807,Q15125,Q92766,Q9UIG0,Q9Y5S9,Q9Y619,P35250 11 +Non hodgkin lymphoma 0.3922535853213686 0.3700862520261861 0.7113182253296533 1.0 0.8846433689818269 8 Q05655,P49327,P00813 3 +Abnormal urine carbohydrate level 0.3570044723639554 0.3692301801076237 0.7119561622530219 1.0 0.8846433689818269 11 Q01968,P29401,O00462,P16278,Q6PGP7 5 +Abnormal neural tube morphology 0.2874110184848601 0.3691148744454546 0.7120421023926999 1.0 0.8846433689818269 39 Q9Y6K9,Q92766,Q9UIG0,Q08J23,P09884,P35250,Q9UHX1,Q10713 8 +Contractures involving the joints of the feet 0.3104872356297493 0.3640866547311162 0.7157933019212412 1.0 0.886527350588485 22 P21333,Q8IZA0,Q8IWS0,Q08J23,P49773 5 +Aplasia hypoplasia affecting the eye 0.2517785828119208 0.3638070586476745 0.7160020913006522 1.0 0.886527350588485 99 O96028,Q15125,Q9NPF4,Q5SRE5,Q8N201,Q9Y6K9,Q9Y4I1,Q7LGA3,P61586,Q00839,O75569,Q9BZH6,O43924,Q96KP1,O15111,O60828,Q9UHX1,Q92766,Q9UIG0 19 +Small hand 0.2887290783095491 0.3634909091862559 0.7162382026310887 1.0 0.886527350588485 32 Q9Y4W2,Q69YQ0,Q9H2P0,Q9UPW6,Q08J23,Q93009,O15111,Q9Y619,Q9H9E3,Q10471,Q12830 11 +Encephalopathy 0.2520019765819251 0.3632192921572921 0.7164410772753818 1.0 0.886527350588485 96 P00403,P43034,Q92947,O75251,Q9NZJ7,Q9BUB7,Q5KU26,O43772,P07602,P09622,Q96CU9,Q9BTW9,Q00839,Q9Y6M9,Q86Y39,P40939,Q9BU61,P23378,Q15067,Q9Y619 20 +Retrognathia 0.2566322086504301 0.3630614284334838 0.7165589971469299 1.0 0.886527350588485 76 Q9BUB7,Q7LGA3,Q2TAA5,O75530,Q15125,Q15392,Q5SRE5,P09884,Q9Y619,Q9Y3B2,Q8N201,O75844 12 +Myalgia 0.2848592982380978 0.3617781093956795 0.7175178518383607 1.0 0.886527350588485 41 Q92890,P49327,P06280,P14854,P31040,O95425,Q92766,P55072,Q01130,P40939,Q9NZ08,Q14739,Q9BUK6 13 +Abnormal aortic valve physiology 0.2875753292878582 0.3616829757297294 0.7175889503971924 1.0 0.886527350588485 37 P49327,Q15125,Q9UIG0,Q9NZ08,P16278,P35250,Q9UHX1,Q6PGP7,O75844 9 +Personality changes 0.3400102160639165 0.3613195307534539 0.7178605951014365 1.0 0.886527350588485 13 P00403,P49770,P55072,O60220,Q9NR50,Q13144 6 +Aplasia hypoplasia involving bones of the thorax 0.2883721041772273 0.3611222154679462 0.7180080867080458 1.0 0.886527350588485 34 Q9BV10,P98175,Q7RTS9,Q14739,Q9Y619,O75844 6 +Biconcave vertebral bodies 0.3997649824227289 0.360613803115398 0.7183881693142529 1.0 0.886527350588485 7 O00170 1 +Accessory spleen 0.4089405215468837 0.3600379702120446 0.7188187388281491 1.0 0.886527350588485 6 Q96KP1 1 +Overlapping toe 0.3042918332779088 0.3592822250003936 0.7193839702432165 1.0 0.886527350588485 24 Q7Z6Z7,P61978,Q8TD19,Q15125,P60953,Q9UHX1,Q9UBM7,Q9H2M9,Q8N201,Q12830 10 +Abnormal cerebellar vermis morphology 0.259437528579387 0.3591320575783657 0.7194963006489787 1.0 0.886527350588485 75 P98175,Q86XI2,O43924,Q9Y4I1,Q8NFH4,Q15125,P78527,Q96KP1,Q9UHD1,Q8N201,Q10713,Q69YQ0 12 +Squamous cell carcinoma 0.3415149236799323 0.3588365920461697 0.7197173367318683 1.0 0.886527350588485 12 P53634 1 +Limited elbow movement 0.2858201542097169 0.3570233718747964 0.7210743090165517 1.0 0.8868769204819917 39 P21333,O00443,Q9Y2D4,Q7LGA3,O75369,Q14807,O95425,P06753,Q9H6K4,Q7RTS9,Q06124,Q8WXH0 12 +Facial asymmetry 0.2876565699285307 0.3559427466725613 0.7218834422258347 1.0 0.887279304990665 34 Q03164,O96028,Q9UPW6,P61586,P52788,Q8NCH0,Q9H9Y6,Q9UHX1 8 +Chronic lymphatic leukemia 0.3435103158009527 0.3556350120052249 0.7221139198361868 1.0 0.887279304990665 4 Q01130 1 +Chronic leukemia 0.3435103158009527 0.3556350120052249 0.7221139198361868 1.0 0.887279304990665 4 Q01130 1 +Large hands 0.3538242880535784 0.3553437240104957 0.7223321029647121 1.0 0.8873091882097389 11 O75530,O00170,Q15022 3 +Abnormal connection of the cardiac segments 0.2763758746409939 0.3532952606660586 0.7238670981848649 1.0 0.8877518569215229 47 Q69YQ0,P98175,Q92766,O15111,O60828,Q9UIG0,Q9UHX1,Q6PGP7,Q6DKJ4,O75844 10 +Apraxia 0.2615981167717173 0.3530155218170436 0.7240768040203254 1.0 0.8877518569215229 60 O43924,Q7LGA3,P35270,O60220,Q9Y619,Q9UGU0,P05067 7 +Global brain atrophy 0.3152492113888679 0.3519323776788264 0.7248889767117175 1.0 0.8877518569215229 20 Q9UHX1,P07602,Q9NZJ7,O60220 4 +Hiatus hernia 0.364652700243566 0.349354150221706 0.7268234501912574 1.0 0.8890088005145337 10 Q9NPF4,Q69YQ0 2 +Spastic diplegia 0.3024609398899623 0.34798970742134 0.7278479132832671 1.0 0.8896395618886812 24 Q9UEY8,Q99720,P07602,Q92947,O60828,Q9NZJ7 6 +Congenital nystagmus 0.318621668626245 0.3474574578501203 0.7282476736523082 1.0 0.8896395618886812 19 P00846,Q7LGA3 2 +Contractures of the joints of the lower limbs 0.259975464391858 0.3473953619010954 0.7282943173045382 1.0 0.8896395618886812 56 Q7LGA3,O95425,Q99720,P06753,Q08J23,P49773 6 +Left ventricular hypertrophy 0.3179284012731064 0.3437101578741178 0.7310642712257573 1.0 0.8913375517848405 19 P00403,O00170,P10253,P06280,Q15233,O95425,P40939 7 +Abnormality of chorioretinal pigmentation 0.3716063870400494 0.343090338952164 0.7315304989260141 1.0 0.8916684669998313 5 P49815 1 +Abnormal heart valve physiology 0.2467710398727902 0.3414912741917486 0.7327337727019483 1.0 0.8924221601002708 85 P46777,Q15125,P60953,P35250,Q6PGP7,Q8WVX9,P21333,O00170,P06280,Q15233,P00813,Q86TI2,P55263,P09493,Q12830,Q8TD19,Q9NZ08,P40939,Q9BU61,Q06124,Q9UHX1,O75844,P49327,Q86XI2,P14854,P16278,Q9UIG0 27 +Melanoma 0.3306149382500538 0.3399398391420692 0.7339018339886731 1.0 0.8928943897305042 15 P21912,P11802,P38398,P53634,Q9NYB0,Q06124 6 +Multifactorial inheritance 0.3349900502081544 0.3379246425658659 0.7354199767385934 1.0 0.893813695812097 13 P35611,P10321,P42892,P38398,A6NHR9,P62873 6 +X linked recessive inheritance 0.2652803888477196 0.3370898906561692 0.7360491380059222 1.0 0.893813695812097 52 Q9NVH6,P21333,O95831,Q9Y6K9,P98175,Q9Y4W2,Q01968,P06280,P52788,Q15125,Q8IWS0,O60220,P09884,O60828 14 +Abnormality of thalamus morphology 0.3325718418543569 0.3370841414691023 0.7360534718428853 1.0 0.893813695812097 14 Q13057,Q96KP1,P49792,Q9BU61 4 +Abnormal pineal morphology 0.3696604165213251 0.3360865963329359 0.7368055657196946 1.0 0.893813695812097 5 Q15233,Q9H7D7,Q10471 3 +Pineal cyst 0.3696604165213251 0.3360865963329359 0.7368055657196946 1.0 0.893813695812097 5 Q15233,Q9H7D7,Q10471 3 +Abnormality of the pineal gland 0.3696604165213251 0.3360865963329359 0.7368055657196946 1.0 0.893813695812097 5 Q15233,Q9H7D7,Q10471 3 +Abnormal odontoid tissue morphology 0.2802565074006081 0.3335657060450204 0.7387073000295321 1.0 0.8949347041384775 42 Q9Y6K9,Q9HC07,Q01968,P61586,Q92766,Q9UIG0,P16278,P35250,Q9UBM7 9 +Underdeveloped supraorbital ridges 0.3334694702529387 0.3309463606531596 0.7406850024818152 1.0 0.8955751450876671 13 Q08J23,Q6PGP7,P50542 3 +Hoarse voice 0.2933111137822149 0.3266422086923212 0.7439385151940794 1.0 0.8979447742730226 28 Q01082,P21333,Q69YQ0,O00170,Q15022,O75530,Q13045,P43243,P06753,Q9UIG0,Q9Y3Z3,Q8N0X7,P35250,Q96HY6 14 +Platybasia 0.3986075800223402 0.3250411302317589 0.7451499429107162 1.0 0.8985722985542853 6 Q92890,Q92766 2 +Tetralogy of fallot 0.2820201918096681 0.3243213120883364 0.7456947862387742 1.0 0.8985722985542853 38 P98175,Q92766,O15111,O60828,Q9UIG0,Q9UHX1,Q6PGP7,Q6DKJ4,Q69YQ0 9 +Chondrosarcoma 0.3025561832050759 0.3238798493009365 0.7460290003290986 1.0 0.8985722985542853 3 Q92804 1 +Broad finger 0.2830493505821743 0.3230854660898602 0.7466305169017935 1.0 0.8986995476077239 34 P21333,Q9H2P0,Q15022,Q9UPW6,Q7Z6Z7,Q7LGA3,O75369,Q14807,O75530,Q08J23,Q9Y5S9,Q9UGU0,Q9UHX1,Q6DKJ4,Q12830 15 +Broad neck 0.3460344316054711 0.3221416182888539 0.7473454105520259 1.0 0.8987388187326911 11 Q12830,Q07864,O95425,P78318 4 +Skin pit 0.3310014619190621 0.3197300508012574 0.7491729773634939 1.0 0.8989911072777904 13 O96028,Q9H488,P62140,Q69YQ0 4 +Hemianopia 0.3968206170624782 0.3191346707336337 0.7496243937152545 1.0 0.8989911072777904 6 P00403 1 +Abnormal systemic arterial morphology 0.23883117072825 0.318587239935216 0.7500395306959933 1.0 0.8989911072777904 137 Q9NZJ7,P35250,P49815,Q7LGA3,P06753,P07602,P55263,P05067,O15118,P10619,P61916,Q9UHX1,O75844,P00846,O75531,Q9H7D7,Q92766,Q9UIG0,P16278,Q9UGU0,Q6DKJ4,Q69YQ0 22 +Aplasia hypoplasia of the uterus 0.3201491816279683 0.3177607444660922 0.7506664298647747 1.0 0.899028315863077 17 Q9BZH6 1 +Hereditary nonpolyposis colorectal carcinoma 0.3960828450830436 0.3167090268706254 0.751464398690715 1.0 0.899028315863077 6 O14965 1 +Flat face 0.2911040707756215 0.3161460906331109 0.7518916241161624 1.0 0.899028315863077 27 Q03164,P21333,Q13555,P50542,Q9BUB7,Q9Y487,Q14807,Q15125,P08236 9 +Telecanthus 0.2788627836042533 0.3161252410749731 0.751907448792628 1.0 0.899028315863077 41 Q03164,Q86XL3,Q69YQ0,Q15125,Q92766,Q08J23,Q8NCH0,Q9Y3B2,O60828,Q00839,O75844 11 +Abnormal sternum morphology 0.2431340761477455 0.3152064221014915 0.7526049297959574 1.0 0.8995073540213464 115 Q03164,O96028,P52788,P60953,Q7RTS9,P35250,Q8N201,O95831,P21333,P98175,Q7LGA3,P78318,P06753,Q08J23,P62873,Q9BTW9,Q9BUK6,Q9Y487,O75718,Q9Y263,P08236,O60828,Q8NCH0,Q06124,Q9UHX1,P62140,O00443,P07437,Q9H9E3,P16278,Q14739,Q9Y619,Q9UIG0,Q8WXH0,Q6DKJ4,Q69YQ0 36 +Abnormality of the cerebrospinal fluid 0.2370451975077506 0.3137375629812055 0.7537203690086913 1.0 0.9004902450933908 129 P49815,P00846,O95831,O96028,P00403,P26358,Q86Y39,Q9NR77,Q15392,Q15125,P07602,O43681,O15382,Q08J23,P51970,Q10713 16 +Limited elbow extension 0.32951666467371 0.3130487981321498 0.7542435884230361 1.0 0.9006727813215847 13 P21333,Q9Y2D4,O75369,Q7RTS9,Q9H6K4 5 +Decreased fertility in males 0.3767708913294314 0.3130183531147262 0.754266718550499 1.0 0.9006727813215847 8 Q06124,O00170 2 +Oligodontia 0.3312329467399723 0.312678698760857 0.7545247805946398 1.0 0.9007459365627716 12 P21333,O00443,Q9UPW6,P61978,P61586 5 +Cerebral palsy 0.3431208361320646 0.3100323847638784 0.7565363293981464 1.0 0.9022060395141522 11 P35270,O00170 2 +Generalized onset seizure 0.247530845670634 0.3095981005224766 0.75686660093392 1.0 0.9023647909545588 96 P00846,Q9UPW6,Q8IYI6,Q14108,Q9H7D7,P07602,P16278,Q6PJG6,Q08J23,Q96N66,Q9Y619,Q9NZJ7,Q9NZ01 13 +Abnormal systemic blood pressure 0.2472084546461394 0.3083972206573057 0.7577800965748345 1.0 0.9029459272221706 90 P49815,P00403,O00170,O75531,Q9BUB7,P42892,O43772,Q13423,Q92766,P07602,O43681,Q9UIG0,Q9NPF4,P35250,Q9NZJ7,Q10713,O75844 17 +Neurodegeneration 0.291554279318398 0.3083854961518416 0.7577890169425363 1.0 0.9029459272221706 26 Q13057,P07737,Q15165,P08236,P43243,Q92804,P55072,Q9Y3Z3,Q6DKK2 9 +Abnormal pharynx morphology 0.2808840175326159 0.3079485832418426 0.7581214568328007 1.0 0.9029459272221706 34 P15586,P16278,P00813,Q7RTS9 4 +Abnormal brainstem mri signal intensity 0.3180117360915617 0.3071712710222562 0.7587130115392735 1.0 0.9029459272221706 17 Q9Y6M9,O95831,Q86Y39,O75251,Q96CU9 5 +Hypoplasia of the frontal lobes 0.3648180300371851 0.3064928580887542 0.7592294167870095 1.0 0.9029459272221706 9 P42695,Q86XL3 2 +Branchial anomaly 0.3746283725040225 0.3054155408058507 0.7600496870295275 1.0 0.9029459272221706 8 P61978,Q9H9Y6,Q9UHX1,P28482 4 +Rib fusion 0.3745784147607299 0.3052391551823303 0.7601840129235684 1.0 0.9029459272221706 8 Q6DKJ4 1 +Long philtrum 0.2356692339216038 0.3041333950491411 0.7610262655653095 1.0 0.9029459272221706 126 Q9Y3B2,P35250,Q8N201,Q6PGP7,Q13555,Q9UPW6,Q9BUB7,Q7LGA3,Q2TAA5,O75530,P06753,Q9Y487,Q8ND04,O75718,P78527,Q96KP1,Q8NCH0,Q9UHX1,Q01968,Q92766,Q9UIG0,P16278,Q6PJG6,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 27 +Elevated circulating glutaric acid concentration 0.3298013245033039 0.3035208757003966 0.7614929408531823 1.0 0.9029459272221706 4 Q16134,Q92947,P38117 3 +Micropenis 0.256236727669155 0.3029979144909154 0.7618914509355523 1.0 0.9029459272221706 60 P48449,Q9BZH6,P42892,P78527,Q9Y619,Q10713,Q9BV10 7 +Broad toe 0.2895558334477359 0.3026034180346001 0.762192109317718 1.0 0.9030222774973128 28 Q9UPW6,Q7LGA3,P61586,Q15125,Q9UGU0 5 +Metopic synostosis 0.2972339745684459 0.3023956565570875 0.7623504654248672 1.0 0.9030222774973128 3 P61978 1 +Elevated urinary delta aminolevulinic acid 0.3293296840084031 0.3017907667127452 0.762811569992554 1.0 0.9031352426691738 4 P36551 1 +Abnormally low pitched voice 0.3735885986750792 0.3017528536924844 0.7628404737074559 1.0 0.9031352426691738 8 O75530 1 +Papule 0.3193847239904455 0.2993239606537229 0.7646928742168391 1.0 0.9043925801784166 16 Q9NZ08 1 +Abnormal 2nd finger morphology 0.3588263707880023 0.298194221452063 0.7655549319047517 1.0 0.9049444533388554 5 P21333,Q9H6K4 2 +Abnormal ovarian physiology 0.2881407467978043 0.2974881176830655 0.7660938783225391 1.0 0.9053477100651334 27 Q05655,P49327,O00170,Q9BZH6,O75844 5 +Progressive hearing impairment 0.3238343382322994 0.2968032756034842 0.7666167045344006 1.0 0.9053538433007752 14 O60220 1 +Tube feeding 0.2556957730765763 0.2953059887526876 0.7677601420543683 1.0 0.905679940768774 63 Q9UPW6,Q99720,P06753,P07602,Q08J23,Q96N66,Q9NZJ7,Q9UHX1,Q9NZ01,Q9BV10 10 +Aplasia hypoplasia affecting the fundus 0.2893192140588357 0.2946474752034481 0.7682631913112647 1.0 0.90569189312469 26 Q9Y6K9,Q9BZH6,Q9Y4I1,Q96KP1,Q00839 5 +Neoplasm of the breast 0.2960999565462276 0.2945156439696308 0.7683639110778175 1.0 0.90569189312469 23 Q05655,P49327,P28340,P21912,O75330,P11802,P38398,P48735,Q07864,P10644,P35222,Q9NYB0,P52701 13 +Aplasia hypoplasia of the cerebellar vermis 0.2553845604045974 0.292481348805144 0.769918618241106 1.0 0.906823858901066 64 P98175,Q86XI2,O43924,Q8NFH4,Q15125,P78527,Q96KP1,Q8N201,Q10713,Q69YQ0 10 +Abnormal cranial nerve physiology 0.2551002365365116 0.2903851887024349 0.7715215734852532 1.0 0.9077340324537366 65 O00170,P50542,Q9H7D7,Q9NR77,P06753,P07602,Q9NZ08,Q9NZJ7,Q9UHX1,Q15043 10 +Aplasia hypoplasia of the ribs 0.2996228285633556 0.2897782781074925 0.7719858667633575 1.0 0.9077340324537366 21 Q03164,P21333,Q96HY6,Q14739,Q9Y619,Q9UHX1,Q9BV10 7 +Abnormal size of the palpebral fissures 0.2406493859633276 0.2883887726423738 0.773049160973686 1.0 0.908002950159834 83 P98175,Q13555,Q7LGA3,P61586,Q5KU26,Q9UIG0,Q9UHX1,Q08J23,Q9Y619,Q9UGU0,Q8N201,Q6DKJ4,O75844 13 +Prominent superficial blood vessels 0.3232474880029226 0.2854085445371825 0.7753311620670083 1.0 0.9099206996873582 13 Q9Y487,O75844 2 +Abnormality of the calvaria 0.2214432614659305 0.2849638720842087 0.7756718207353901 1.0 0.910087137530346 253 Q03164,P15586,O96028,P43034,P52788,Q15125,Q96F07,Q5SRE5,Q7RTS9,Q9H9Y6,Q8N201,Q6PGP7,Q15043,O95831,Q9Y6K9,O00170,P98175,Q9UPW6,Q9BUB7,Q15392,Q08J23,P55263,Q9BTW9,Q00839,Q9BV10,Q05655,O43924,Q8IYI6,Q9Y487,Q8ND04,O75718,P09884,O60828,O15111,Q8NCH0,O75844,Q01968,Q86XI2,O75531,P50542,Q92766,Q15067,Q13045,Q8IWS0,Q9H9E3,P16278,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 53 +Abnormal visual fixation 0.385433286619795 0.2825610759958254 0.7775133216459711 1.0 0.9113133093914494 6 P49792,Q5KU26 2 +Delayed ability to sit 0.3224443157627805 0.2819356735533773 0.7779928350798002 1.0 0.9114085503353584 13 P10253,P43034,Q9H7D7,Q10713,Q10471 5 +Abnormal endocardium morphology 0.3180678492086116 0.2810966844128479 0.7786362441447681 1.0 0.9116955971989265 15 Q9NZ08,P49327,Q9UIG0,P35250 4 +Abnormal hand bone ossification 0.3762629378410102 0.2798998479029588 0.7795543439148493 1.0 0.911818503987632 7 P21333,O75369,Q15125 3 +Joint dislocation 0.2412104563895703 0.2786121883574964 0.7805424580035674 1.0 0.9119423440073704 85 O96028,P43034,Q15125,Q9NPF4,Q92947,P35250,Q14807,P06753,Q9BTW9,Q9Y487,Q8NCH0,Q9UHX1,O75844,Q01968,Q92766,Q9Y619,Q9UIG0,Q9UBM7,Q6DKJ4 19 +Corneal neovascularization 0.3838757267382889 0.2777061832786688 0.7812379136667902 1.0 0.9119423440073704 6 Q92766 1 +Pigmentary retinopathy 0.2732216690685691 0.2747633878514888 0.7834980280879842 1.0 0.9134158111458746 41 P00846,P00403,Q86XI2,P50542,Q15067,P40939,O75251,Q96CU9,Q9Y6X9 9 +Tetany 0.3826720343798834 0.2739793296306113 0.7841005066489888 1.0 0.9138854135300284 6 Q92890,Q92766 2 +Vestibular dysfunction 0.2848843427649717 0.2734395546052522 0.7845153506879297 1.0 0.9141361405546472 28 P49327,O00170,Q9NZ08,O60220,Q92947,P41440,Q15043 7 +Thickened calvaria 0.3549097420833582 0.2706420073041967 0.7866663839668431 1.0 0.9150119541083204 9 Q8IWS0,P21333,P16278,Q7RTS9 4 +Abnormality of the shoulder girdle musculature 0.2782082052293108 0.2676982303910273 0.7889316120599399 1.0 0.916947686236248 31 P21333,P11047,Q9Y487,P43243,A6NHR9,P06753,O14979,P07602,Q9Y5S9,Q9Y5L0,P55072,Q06124,Q9NZJ7,Q8WXH0 14 +Wrist flexion contracture 0.3494534614110727 0.266996920271542 0.7894715323136605 1.0 0.9171722301059456 5 O60231,P21333,O94905,Q969X5 4 +Gaze evoked nystagmus 0.3434605606184754 0.266769042468354 0.7896469912293429 1.0 0.9171722301059456 10 O15020,Q10713,P41440 3 +Atrophic scars 0.3799641802333489 0.2656759478149804 0.7904887887210679 1.0 0.917335646910243 6 P53634 1 +Spinal rigidity 0.3200531208499342 0.2651940177616866 0.7908600031084188 1.0 0.917335646910243 12 P02545,Q13642,Q5JTV8,O94905,Q9BQP7,P06753,Q9Y5L0,Q9Y281,Q8NF91,P50402,Q8WXH0 11 +Prominent nasal bridge 0.2637224581348857 0.2644905684501082 0.791401931422181 1.0 0.9175136304516804 48 Q69YQ0,O43924,Q9UPW6,Q15125,P42892,Q08J23,Q10713,Q9BV10 8 +Functional abnormality of the gastrointestinal tract 0.221587580818051 0.2620150166612328 0.7933098649036971 1.0 0.9175136304516804 266 Q03164,P15586,O96028,P00403,Q14108,Q9NR77,O60220,Q92947,Q96F07,O15269,Q9Y584,Q9NZJ7,Q6PGP7,P35250,P49815,P07737,P21333,Q9UEY8,O15143,Q9UPW6,P06280,Q8IZA0,Q01130,P07602,P50336,P06753,P36551,P05067,Q9BTW9,O15118,Q9BV10,Q05655,O75569,P42892,Q99720,Q9NZ08,Q9BU61,P09884,P61916,Q9UHX1,P00846,P49327,Q01968,P49257,Q86XI2,Q9H7D7,Q9BUF5,Q92766,Q15067,Q13045,Q9H9E3,P08183,Q14739,Q9Y619,Q9UIG0,Q9UBM7,Q69YQ0 57 +Visual impairment 0.2217959813503684 0.2613485281024633 0.7938237465241105 1.0 0.9175136304516804 269 P00403,O15484,Q9NPF4,O43681,O60220,O75251,Q9UHD1,Q9NZJ7,P35250,Q15043,O95831,Q9Y6K9,O00170,Q7LGA3,P61586,Q5KU26,P07602,P09622,Q08J23,Q6P4A7,Q96CU9,P48449,Q9Y6M9,P04439,Q9BZH6,Q86Y39,P78527,P50897,Q9NZ08,P40939,Q9BU61,P13473,P09884,O60828,Q96N66,Q9H061,Q9UHX1,Q9NZ01,P00846,Q6P2Q9,P49327,Q86XI2,P50542,P68371,Q9H7D7,Q9UIG0,P16278,Q6PJG6,O75503,Q9UGU0,Q10713 51 +Finger syndactyly 0.2739103322813273 0.2609529055564411 0.7941288251041567 1.0 0.9175136304516804 33 Q9Y6K9,P98175,O75530,Q9Y619,Q6DKJ4,Q69YQ0 6 +Abnormality of fontanelles 0.2632516154778151 0.2608593583820555 0.7942009672550163 1.0 0.9175136304516804 48 P21333,P98175,P50542,O75531,Q9Y487,O75718,Q15125,Q08J23,O15111,Q8NCH0,Q9Y619,Q9H9E3,O75844 13 +Varicose veins 0.3783645459769675 0.2608238187254723 0.7942283753563828 1.0 0.9175136304516804 6 Q92890,Q92766 2 +Venous insufficiency 0.3783645459769675 0.2608238187254723 0.7942283753563828 1.0 0.9175136304516804 6 Q92890,Q92766 2 +Abnormality of the lymph nodes 0.2733895486829796 0.2604317969889769 0.7945307184677339 1.0 0.9176298507259192 37 Q9NZ08,P00813,P14174 3 +Conspicuously happy disposition 0.3174600734325933 0.2597147843861262 0.7950837875888905 1.0 0.9176575763363588 4 Q92581,Q9UPW6 2 +Reduced consciousness confusion 0.2361869491621527 0.2583970204795966 0.7961005158547643 1.0 0.9178718500883932 120 P00403,P26358,P46777,P35270,O43681,Q92947,O75251,Q9NZJ7,Q07020,P15289,O43772,P07602,P09622,P50336,P36551,Q96CU9,P05067,Q9Y6M9,P20674,Q86Y39,P11182,Q9NZ08,P40939,P31751,Q9BU61,P49327,P23378,P61313,Q13423,Q9Y619,Q9UBM7 31 +Abnormal left ventricle morphology 0.2895398909835765 0.2578199056990511 0.7965459011850293 1.0 0.9178718500883932 23 P00403,O00170,P10253,P06280,Q15233,O95425,P40939,Q06124 8 +Hyperreflexia in upper limbs 0.3693232429797073 0.2577003742774579 0.7966381572274184 1.0 0.9178718500883932 7 Q8WVX9,P31040 2 +Abnormality of limb epiphysis morphology 0.2828404674616705 0.2575699604472038 0.7967388157084416 1.0 0.9178718500883932 29 Q7LGA3,O95831,Q7RTS9,P50542 4 +Glomerular sclerosis 0.276624984752846 0.2575611002895362 0.7967456544464029 1.0 0.9178718500883932 31 Q14108,Q92621,P00403,Q8NFH4 4 +High pitched voice 0.3295909434488296 0.2561596965100298 0.7978275280678175 1.0 0.9185740338241132 11 Q9Y6X9,O75844 2 +Abnormal vitreous humor morphology 0.359947219170606 0.2553971566482035 0.7984163666593087 1.0 0.9186758882088454 8 P04439 1 +Expressive language delay 0.3505241831579442 0.2553572746356256 0.7984471669859705 1.0 0.9186758882088454 9 P34897,Q9UHX1,P62873 3 +Abnormal myocardium morphology 0.2350622652394349 0.2534164524550637 0.7999464152873699 1.0 0.9194763291738554 164 P15586,P00403,Q14108,Q99797,O75251,P35250,O00170,Q9BUB7,O43772,P06753,P09622,Q96CU9,P09493,Q9Y6M9,Q86Y39,P08236,Q9NZ08,P40939,P35573,Q9BU61,P13473,Q9H061,P00846,P50542,Q13423,P16278,Q9UIG0 27 +Abnormal urine cytology 0.2721664046181787 0.2521470949721426 0.8009273691273591 1.0 0.9196401998373812 37 P49815,P09601,Q14108 3 +Bicornuate uterus 0.367506186339041 0.2520193067637984 0.801026140710944 1.0 0.9196401998373812 7 Q69YQ0 1 +Abnormality of the choanae 0.2716000952025139 0.2466358533654358 0.8051900545456332 1.0 0.9221971168433348 36 Q92890,P42356,Q92766,A6NHR9,P78318,P38398,P62913,Q9H9Y6,Q9UBM7,Q53EZ4,O75844 11 +Preaxial hand polydactyly 0.3479502672044554 0.2465594586947339 0.8052491832432409 1.0 0.9221971168433348 9 O96028 1 +Generalized onset motor seizure 0.2580143774339838 0.2455229647210516 0.8060515289606955 1.0 0.9221971168433348 50 P00846,Q8IYI6,P07602,P16278,Q6PJG6,Q9Y619,Q9NZJ7 7 +Thromboembolism 0.3132450331125688 0.2454761485058322 0.8060877740263834 1.0 0.9221971168433348 4 Q14315,P10644,O95235 3 +Generalized myoclonic seizure 0.2702724845958472 0.2449804123946618 0.8064715979572918 1.0 0.9223439539856384 39 P00846,P07602,P16278,Q6PJG6,Q9Y619,Q9NZJ7 6 +Round face 0.2948279217812343 0.2438498283712745 0.8073471274473121 1.0 0.9226429752608027 20 Q03164,Q8IYI6,O75718,O75530,Q69YQ0 5 +Recurrent pneumonia 0.2908220888880574 0.2433413604640308 0.8077409661066282 1.0 0.9226429752608027 21 P00813,Q9BV10 2 +Shawl scrotum 0.3720291150031381 0.2420009014947449 0.8087794646977662 1.0 0.9226573801423126 6 Q9Y619 1 +Abnormal left ventricular outflow tract morphology 0.3121271614728357 0.2417639284386017 0.8089630907824121 1.0 0.9226573801423126 4 Q06124,O43684 2 +Subvalvular aortic stenosis 0.3121271614728357 0.2417639284386017 0.8089630907824121 1.0 0.9226573801423126 4 Q06124,O43684 2 +Abnormality of finger 0.2211948169097454 0.2411808514630571 0.8094149512298798 1.0 0.9229427582907724 275 Q03164,O96028,P43034,P46777,Q15125,Q9NPF4,Q7RTS9,P49773,P35250,Q07020,O95831,Q9Y6K9,O00170,P98175,Q9UPW6,Q9BUB7,Q7LGA3,O75530,Q14807,Q08J23,Q9BV10,Q9H4L7,O43924,P42892,P78527,P09884,O60828,O15111,Q8NCH0,Q9UHX1,O75844,Q9Y6X9,Q86XL3,Q9Y4W2,Q01968,O75531,P50542,P61313,Q8NFH4,Q06136,Q92766,Q15067,Q9UIG0,Q13045,P53634,Q8IWS0,Q6PJG6,Q9H9E3,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 55 +Skeletal muscle atrophy 0.2344863268033429 0.2407117170610379 0.8097785570545535 1.0 0.9231273862113802 148 Q9UHD1,O95831,P07737,P50542,Q9NR77,Q15165,Q99720,P06753,P16278,O15269,P55263,P51970,P49773,Q13126,Q9Y6X9 15 +Deviation of the hand or of fingers of the hand 0.2403059982340823 0.2403101678873931 0.8100898131044534 1.0 0.9232522596063454 106 Q03164,Q9Y2D4,P43034,Q15125,P60953,Q7RTS9,P35250,P21333,Q9Y6K9,P42356,Q9UPW6,Q15233,Q08J23,Q9Y5S9,Q12830,Q9BV10,O43924,P34897,Q8TD19,P78527,P09884,O60828,Q9H2M9,Q9H6K4,Q06124,Q9UHX1,O43684,O75369,Q8NFH4,P38398,Q9UIG0,Q13045,Q6PJG6,Q93009,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q53EZ4,Q6DKJ4,Q69YQ0 41 +Abnormality of the musculature of the limbs 0.2345092310605741 0.2387105321335712 0.8113300493628579 1.0 0.923975525238567 153 P00846,Q9NZJ7,Q9NR77,Q15125,Q99720,P35270,P07602,P06753,P40939,Q15067,P42695,Q7RTS9,Q14739,O95298,P49773,O15269,Q13126,Q9Y6X9 18 +Aplasia hypoplasia of the spleen 0.3105960264900595 0.2367234621829573 0.8128713320351642 1.0 0.924991280015784 4 Q86Y56,Q8TD19,Q7L590 3 +Abnormal brain lactate level by mrs 0.3449648336214141 0.236518502424578 0.8130303516503166 1.0 0.924991280015784 9 P00403,Q9BU61,Q15046 3 +Hyperammonemia 0.2693623961749668 0.2357296449014817 0.8136424647441207 1.0 0.925005441739931 38 Q9BUB7,P09622,P40939,O43772 4 +Abnormality of prothrombin 0.3093756772144154 0.2343368144071458 0.8147235076891148 1.0 0.9255372287647254 14 P40939,Q9BV10 2 +Abnormal circulating igm level 0.3045110279468625 0.231613066542775 0.816838557824247 1.0 0.9265664021015286 16 P00813,Q9Y6K9 2 +Abnormality of the thymus 0.3016952976911317 0.230517452137002 0.8176897037666266 1.0 0.9265664021015286 17 P00813,Q6PGP7,P50542 3 +Abnormality of mouth size 0.2369083089890613 0.2304554633950161 0.8177378671683011 1.0 0.9265664021015286 114 P15586,P43034,P52788,Q9NPF4,Q9H9Y6,P35250,Q6PGP7,Q9UPW6,Q9BUB7,Q7LGA3,Q15392,Q08J23,Q9Y487,O60828,Q8NCH0,O75844,P28340,Q9UGU0,Q92766,P16278,Q9Y619,Q9UIG0,Q9UBM7,Q6DKJ4 24 +Multiple renal cysts 0.3015616152303446 0.2299217019470429 0.8181526123272649 1.0 0.9265664021015286 17 P49815,Q9UIG0,Q92766,P35250 4 +Abnormal number of teeth 0.2471954840031307 0.2295214967711521 0.8184636145283986 1.0 0.9265664021015286 73 O96028,Q9Y6K9,Q01968,Q9BZH6,Q9UPW6,P61586,Q8ND04,Q9UIG0,Q15067,P53634,Q96F07,Q9UBM7,Q9H9Y6,P35250,Q9UHX1,Q6DKJ4,O75844 17 +Abnormal vascular morphology 0.2139163118271866 0.2275664877047862 0.819983275324023 1.0 0.9278278000390738 220 P46777,Q9H9Y6,Q9NZJ7,P35250,Q6PGP7,Q07020,P49815,P21333,O15143,P98175,Q7LGA3,Q15392,O75530,P06753,P07602,P55263,P05067,O15118,Q9BV10,Q05655,Q9Y487,Q8ND04,O75718,P42892,P08236,Q9NZ08,P10619,P09884,O60828,O15111,P61916,Q9UHX1,O75844,P00846,P49327,Q86XI2,O75531,P61313,Q9H7D7,Q92766,Q9UIG0,Q9H9E3,P16278,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 47 +Nephritis 0.2838074097673951 0.2270254238615147 0.8204039728844166 1.0 0.9280743904824456 23 Q05655,P49327,Q92621,Q8NFH4,Q8N1F7,P35579,Q14C86 7 +Abnormal incisor morphology 0.297129768375781 0.2228101023411 0.8236833051134294 1.0 0.9302924233358372 18 Q7LGA3,Q9Y6K9 2 +Panniculitis 0.3495759367163085 0.2223769627987408 0.8240204438896186 1.0 0.9302924233358372 8 Q05655,P49327,Q9Y3Z3 3 +Duplication of hand bones 0.2531259829064649 0.2213355555992735 0.8248311670650152 1.0 0.9303530895298204 51 O96028,P21333,P98175,O43924,P61313,P46777,Q15125,Q13045,Q92766,Q15067,Q9UHX1,Q14739,Q9UBM7,Q10713,Q07020 15 +Abnormality of circulating adrenocorticotropin level 0.3402005447892789 0.2208655643494259 0.8251971109445266 1.0 0.9303530895298204 9 Q13423 1 +Vertebral fusion 0.3305166872545952 0.2207796018075536 0.8252640470812915 1.0 0.9303530895298204 10 Q9UHX1,Q9Y5S9,P21333,O96028 4 +Periorbital edema 0.2764345001962405 0.2191854865612838 0.8265055606615819 1.0 0.9309283926967168 26 Q01082,P52565,O00170,P50542,Q92621,Q8NFH4,Q9UIG0,A6NHR9,Q8N1F7,Q14C86,Q27J81,P35250 12 +Abnormal neuron morphology 0.2776084449159615 0.2190797342301568 0.8265879370590903 1.0 0.9309283926967168 25 Q15165 1 +Sleep apnea 0.283968635688461 0.2175560304059583 0.8277750464913294 1.0 0.9316092789604556 22 O00170,P11047,Q9H0U9,Q9UPW6,Q96KP1,Q93009 6 +Abnormality of the nasal dorsum 0.2507900577151606 0.2175199869649609 0.8278031325174073 1.0 0.9316092789604556 52 O96028,O75531,Q15125,P16278,Q5SRE5,Q6PGP7,O75844 7 +Abnormal circulating pyruvate family amino acid concentration 0.285218669699187 0.2151770750805636 0.8296292637284848 1.0 0.9329762014951536 21 P00846,P20674,Q9BUB7,Q99797,P22695,O95298 6 +Motor neuron atrophy 0.2848036387675842 0.2131364276927705 0.8312205521708453 1.0 0.9341401558576128 21 Q15165 1 +Clinodactyly 0.2311208615719851 0.2130646090877924 0.8312765686711945 1.0 0.9341401558576128 136 Q15125,Q5SRE5,Q7RTS9,P98175,Q7LGA3,P61586,Q08J23,Q9BV10,O43924,P09884,O60828,Q86XI2,Q8NFH4,Q6PJG6,Q9Y619,Q9UGU0,Q10713,Q6DKJ4,Q69YQ0 19 +Eczema 0.2657701911380253 0.2120849696604352 0.8320407454599781 1.0 0.9345399980295264 38 Q08J23,Q14739,Q8ND04,P22830 4 +Slender long bone 0.3049568475817727 0.2104258750181797 0.833335299374687 1.0 0.935084247709716 13 Q9Y619 1 +Bruxism 0.3608662450044443 0.2104166416588856 0.8333425052234937 1.0 0.935084247709716 6 P61978,Q01082 2 +Impaired smooth pursuit 0.2941757765430715 0.2095508483348177 0.8340182451346418 1.0 0.9356131147012882 18 O15020,P43034,P54136,P13639,P41440,P62873,Q10713,Q9BTW9 8 +Submucous cleft soft palate 0.2717643164514956 0.2092021855144112 0.8342904063799133 1.0 0.935689093359682 3 Q15233,O14802 2 +Generalized hypotonia 0.2177709170968297 0.2088818656090467 0.8345404610463556 1.0 0.9357402474789734 345 Q03164,Q9BWD1,Q9NR77,P52788,Q92947,Q96F07,Q70HW3,O95831,Q13555,P15289,O43772,P07602,P09622,Q9H267,O15118,Q53H12,Q8N511,O15020,O43924,P11047,P11182,P61916,Q15022,P07437,P14854,O00462,P49770,P62266,Q93009,P60174,Q2M389,P29401,O43681,Q9Y4I1,Q9BUB7,Q5KU26,O75530,P06753,Q08J23,P55263,Q9BV10,Q86Y39,P50897,P40939,Q9UBX3,Q9Y6X9,Q9HC07,Q86XI2,P50542,Q9Y619,Q9UGU0,Q10713,Q69YQ0,O96028,Q15125,Q99797,Q9NZJ7,P98175,Q00839,Q9Y487,Q96N66,Q9UHX1,Q9NZ01,P23378,Q9H7D7,O14949,Q96NT0,Q9NPF4,O75251,Q14807,Q6P4A7,Q96CU9,Q9BUK6,Q9Y6M9,O14617,Q8NCH0,Q8IWS0,Q9H9E3,Q9UBM7 79 +Glutaric aciduria 0.3299105664127307 0.2070758263566953 0.8359506406945074 1.0 0.9359457148871724 5 P35914,Q92947,Q16134,P38117 4 +Long palpebral fissure 0.2776978682873549 0.2065262219867608 0.836379884039349 1.0 0.9359683934591932 24 Q5KU26,Q13555 2 +Cerebral cortical atrophy 0.2382856080136042 0.2058112852248686 0.8369383255813367 1.0 0.935978750789918 95 Q9Y619,P00846,Q9Y6K9,O43924,Q9Y4I1,Q9BUB7,Q7LGA3,Q5KU26,P51970,Q9UGU0,P05067,Q69YQ0 12 +Hyperintensity of cerebral white matter on mri 0.2832860144685657 0.2057289701215061 0.8370026277000511 1.0 0.935978750789918 21 Q9BUK6,P15289,P07602,O43681,O75503,Q9NZJ7,Q15043 7 +Type 1 muscle fiber atrophy 0.3350765359449284 0.2045515814619139 0.8379224877974731 1.0 0.9362155135920932 9 P06753,Q8WXH0 2 +Focal onset seizure 0.2410397311895713 0.2043926972538542 0.838046636480525 1.0 0.9362155135920932 76 P00403,Q2M389,P43034,P52788,Q9NZJ7,Q8WVX9,P49815,P21333,P07602,Q08J23,Q01105,P62873,O14617,Q96N66,Q9NZ01,Q9UBX3,P54136,Q6PJG6,O75503 19 +Food allergy 0.3003311258278036 0.2042784909903203 0.8381358772749905 1.0 0.9362155135920932 4 Q01082,Q9Y5S9,O95394 3 +Abnormal natural killer cell morphology 0.328585624378941 0.2032776630215137 0.8389180133702254 1.0 0.9365189627306152 5 P33991,O00203,O95394,Q7L590 4 +Reduced natural killer cell count 0.328585624378941 0.2032776630215137 0.8389180133702254 1.0 0.9365189627306152 5 P33991,O00203,O95394,Q7L590 4 +Hyperkeratosis 0.2449246466617608 0.2027894861144939 0.8392995760655375 1.0 0.936592940445578 54 Q9Y6K9,Q06136,P53634,O15269,P09884,Q9H488,P09493,O75844,Q9H4L7 9 +Lower limb asymmetry 0.3503500562528939 0.2011983355931779 0.8405434928879032 1.0 0.9371906375025416 7 Q9UPW6,P07437 2 +Intracranial hemorrhage 0.2763382490284118 0.1994332759978636 0.8419238327788003 1.0 0.9378158633800364 24 P05067,O75844 2 +Hypocalcemia 0.2983802308293625 0.1972233577069868 0.8436527527745108 1.0 0.937915630179484 15 P40939,Q9BV10 2 +Inguinal hernia 0.229636979513627 0.1963950261420943 0.8443009890196758 1.0 0.938046346519936 80 P43034,P60953,P35250,Q6PGP7,P21333,Q9UPW6,Q9BUB7,O75530,P51970,Q9Y487,P08236,Q8NCH0,Q9UHX1,Q01968,Q15022,P07437,Q92766,P16278,Q6PJG6,Q9UIG0,Q10713,Q6DKJ4,Q69YQ0 23 +Abnormality of fluid regulation 0.2306039675713441 0.1963075579388676 0.8443694461057125 1.0 0.938046346519936 169 P26358,P46777,Q14108,Q92621,Q15125,Q9NPF4,P22830,P35250,Q00535,Q07020,P49815,Q9Y6K9,O00170,P14174,P00813,Q9BV10,P04439,Q05655,P11182,P08236,Q9NZ08,P40939,P10619,Q6P2Q9,P49327,Q01968,P50542,P61313,Q8NFH4,P16278,Q14739,Q9UIG0,Q9UBM7 33 +Gastrointestinal hemorrhage 0.2636290825192148 0.1959515584586519 0.8446480816155217 1.0 0.938046346519936 33 P49815,P49257,Q9NZ08,Q14739,Q9UHX1 5 +Aplasia hypoplasia of the phalanges of the hand 0.2526423043898921 0.1931887512306749 0.846811148012439 1.0 0.9391457776721428 49 Q03164,Q8IWS0,Q14739,O15111,Q7RTS9,Q9H9E3,Q9UHX1,Q6DKJ4,O75844 9 +Abnormal blood glucose concentration 0.2364499623164312 0.1917599346340547 0.8479302559973647 1.0 0.9399314075320752 90 Q9BV10,Q9Y6M9,Q9BZH6,Q86Y39,P11182,O43772,Q13423,P22695,P40939,P09622,P35573,P31751,P53985,O75251,Q96CU9,O75844 16 +Sclerocornea 0.3295410523355597 0.1875495673566387 0.8512297639634949 1.0 0.9424476607791282 9 O96028,O75569 2 +Recurrent fractures 0.2707117666357893 0.1866533068306595 0.8519324683338036 1.0 0.9429429189306454 29 Q13126 1 +Heart block 0.2736803229886815 0.1857895567365477 0.8526097944674798 1.0 0.9429429189306454 24 O43772 1 +Specific learning disability 0.2428195694595383 0.1855207823467907 0.85282058123697 1.0 0.9429429189306454 61 P49815,Q9Y4W2,Q9Y4I1,Q9Y619,P49773,Q10713,Q9Y6X9 7 +Systemic lupus erythematosus 0.3513973045456527 0.1852710916348436 0.8530164110180201 1.0 0.9429429189306454 6 Q05655,P49327 2 +Hypertensive crisis 0.3509326748379422 0.1840771873468839 0.8539529025231682 1.0 0.9434386554597678 6 Q92766 1 +Abnormal tricuspid valve morphology 0.2988440295791088 0.1837799295291269 0.8541861018626344 1.0 0.9434386554597678 12 Q92890,P21333,Q92766,Q6DKJ4 4 +Movement abnormality of the tongue 0.2930463576158845 0.182717800690264 0.8550194479611479 1.0 0.9437284784027782 4 P04350,P08754,P10253 3 +Stroke 0.264303731076299 0.1826571052473244 0.8550670744890367 1.0 0.9437284784027782 31 P21333,P00403,Q9UIG0,P51970,P35250,P05067,O75844 7 +Attenuation of retinal blood vessels 0.34227282567742 0.1791111805395695 0.8578504031693275 1.0 0.9463504292530894 7 Q96S66,P04439,P38435 3 +Facial edema 0.2675530538721306 0.1776043875383738 0.8590336785720936 1.0 0.9467366113230128 27 Q01082,P52565,O00170,P50542,Q92621,Q8NFH4,Q9UIG0,A6NHR9,Q8N1F7,Q14C86,Q27J81,P35250 12 +Reticulocytosis 0.3166658608401275 0.1757034247769015 0.8605269445827664 1.0 0.9478763725853137 10 P36551,Q05655 2 +Abnormality of vitamin b12 metabolism 0.3068551035007019 0.175231252268363 0.8608979284762639 1.0 0.9478782339754294 11 Q05655,P41440 2 +Tachypnea 0.2795757409913685 0.1721130398599976 0.8633486614159396 1.0 0.9496327605214598 20 Q9Y619,O43924 2 +Sloping forehead 0.2573484432976957 0.1719580634611443 0.8634704983288142 1.0 0.9496327605214598 42 Q13057,Q86XL3,P98175,Q9NPF4,P42695,Q96KP1,Q08J23,Q9H267,Q9H9E3 9 +Thick hair 0.3395544621010806 0.1719526698307752 0.8634747386669681 1.0 0.9496327605214598 7 Q9Y487,Q9BUK6 2 +Abnormal pulmonary thoracic imaging finding 0.2744062765285913 0.1708974414643941 0.8643044084841189 1.0 0.9501821702106864 22 P49815,P49327,Q05655,Q01968,Q92766,Q9NZ08 6 +Vascular neoplasm 0.2594855184473823 0.1702849095324047 0.8647860783879047 1.0 0.9502128728989048 34 P49815,Q7LGA3,O96028,P10619 4 +Decreased activity of mitochondrial complex iv 0.2912360190025133 0.1696099326605105 0.8653169106030911 1.0 0.950384793659197 15 Q70HW3 1 +Abnormality of skin adnexa physiology 0.2574870388565941 0.1685922534274473 0.8661173742095061 1.0 0.950424172082692 41 Q9Y6K9,P35270,O15269,P09884,P49773 5 +Abnormality of hair texture 0.2423139742820944 0.1678649251189172 0.8666895442186402 1.0 0.9505962242723978 53 P15586,Q9Y6K9,Q9UPW6,O75530,Q15125,Q08J23,O60828,Q6PGP7,O75844 9 +Abnormal pattern of respiration 0.2280851857990173 0.1663421105542546 0.8678877282105582 1.0 0.951454402878976 172 Q9NZJ7,P49815,P07737,O95831,O00170,P98175,Q15165,O43772,P06753,P07602,P51970,O43924,Q86Y39,Q96KP1,O75844,P00846,P50542,Q6PJG6,Q9Y619,Q10713 20 +Abnormality of the musculature of the hand 0.2587975034813244 0.1659864277311654 0.8681676311077853 1.0 0.9515333447270912 36 Q9NR77 1 +Severe viral infection 0.3431062239893748 0.1645392776914342 0.8693066289496696 1.0 0.95222646216362 6 Q9Y6K9,P17812 2 +Unusual infection 0.220395678074821 0.1606303467116719 0.8723845520358344 1.0 0.9538348321036648 199 P15586,O96028,P09601,O95298,Q7RTS9,Q9NZJ7,P49815,Q9Y6K9,P14174,Q9Y4I1,Q9BUB7,P00813,P06753,P07602,Q08J23,Q9BV10,P78527,Q9NZ08,P09884,P50542,Q13423,P53634,P16278,Q14739,Q6DKJ4 25 +Hamartoma 0.2868517280669681 0.1597649951019559 0.8730661996841462 1.0 0.9538348321036648 16 P49815,O43924,P31040,Q8TD19,P11802,Q92947,P52701 7 +Reduced tendon reflexes 0.2286421280057193 0.1592643692297396 0.8734605916414706 1.0 0.9538348321036648 161 P00846,O95831,Q9Y3B2,P26358,P50542,Q9NR77,Q99720,P06753,P07602,O43681,P40939,Q15067,O15269,P41440,P49773,Q9NZJ7,Q10713,Q9Y6X9 18 +Cerebral hypoplasia 0.2884470026933455 0.159263500329896 0.873461276186215 1.0 0.9538348321036648 15 Q13057,P42695,Q86XL3,Q9UBM7 4 +Limb girdle muscular dystrophy 0.3197346600331604 0.1590627007982713 0.8736194744775634 1.0 0.9538348321036648 9 P02545,Q13642,P09651,O14979,Q8NF91,Q7Z392,P50402,Q8WXH0 8 +Abnormality of the musculature of the thigh 0.3197346600331544 0.1590627007982544 0.8736194744775767 1.0 0.9538348321036648 9 P02545,Q13642,P07196,O14979,Q8NF91,Q14204,P50402,Q8WXH0 8 +Short palm 0.2731995465602004 0.1587414249794413 0.8738725995472705 1.0 0.9538348321036648 21 Q9Y619,Q9H9E3,Q9UHX1,Q13555 4 +Cortical dysplasia 0.2655566670052428 0.1585560805854292 0.8740186335684446 1.0 0.9538348321036648 29 P49815,P07437,P08243,Q08J23,Q96N66,Q9NZ01 6 +Progressive microcephaly 0.2570869568183638 0.1579402784202544 0.8745038587816649 1.0 0.95390947608286 38 Q5KU26,Q6PJG6,Q15043,Q9BV10 4 +Immunodeficiency 0.2394062042088282 0.156819249499131 0.8753873016489928 1.0 0.9540728768634772 62 O96028,Q9Y6K9,Q05655,P14174,P00813,O14617,P78527,Q92766,P09601,Q6PGP7 10 +Morphological abnormality of the corticospinal tract 0.2902073466431001 0.1566921738122137 0.8754874552821945 1.0 0.9540728768634772 13 P00846,P35250,Q13045,Q9UIG0 4 +Upper limb undergrowth 0.278645114350104 0.1551639178367659 0.8766920931228332 1.0 0.9547526327371448 19 Q14739,P98175,Q9BV10 3 +Periauricular skin pits 0.3002545370406324 0.1541855952900655 0.8774633996660648 1.0 0.955089174856499 11 O96028,P62140,Q69YQ0 3 +Gastrointestinal obstruction 0.2893610995634888 0.1538036110354653 0.8777645865237984 1.0 0.9551898508129876 13 P21912,P31040,P42892,P38398,Q15813,P50336 6 +Patellar dislocation 0.2751733540567576 0.1530047446119238 0.8783945336900307 1.0 0.955362636736038 20 Q92890,P21333,Q01968,Q9Y2D4,Q15125,Q92766,Q9UIG0,Q9Y5S9,P35250 9 +Urinary incontinence 0.2548196320615489 0.1520672405842038 0.8791339018999409 1.0 0.955362636736038 41 P26358,Q99720,P07602,O43681,Q9Y6X9 5 +Abnormality of the abdominal organs 0.2160732521191963 0.1518054199346258 0.879340407193367 1.0 0.955362636736038 335 P15586,O96028,P00403,P11717,Q14108,P09601,O43681,P22830,Q9NZJ7,P49815,P14174,Q9BUB7,P00813,Q15392,O43772,P07602,P09622,P55263,O15118,Q8N511,Q86Y39,P11182,Q9NZ08,P40939,P10619,Q96KP1,P61916,P00846,Q9HC07,P50542,Q8NFH4,Q15067,P53634,P16278,Q14739,Q9Y619,Q10713,Q69YQ0 38 +Abnormality of the 1st metacarpal 0.3170914614933993 0.1517495364133489 0.8793844851581665 1.0 0.955362636736038 9 O60828 1 +Abnormality of muscle size 0.2263391905958813 0.1510298478882418 0.8799521707450364 1.0 0.9555879762586446 176 Q9NR77,Q96NT0,O15269,Q9UHD1,P49773,P35250,Q13126,Q13057,P07737,O95831,O00170,Q7LGA3,Q15165,P06753,P55263,Q6P4A7,P51970,Q9BTW9,Q9Y487,Q99720,P13473,O60828,Q9Y6X9,P50542,P16278,Q9UIG0,Q10713 27 +Acanthosis nigricans 0.3083992613494442 0.1509572173122626 0.8800094646996257 1.0 0.9555879762586446 10 O00170 1 +Infection related seizure 0.2800756150940146 0.1503311218549627 0.8805033802962985 1.0 0.9556907666755224 18 Q9H7D7,P05067,Q9BTW9,Q96N66 4 +Abnormal macular morphology 0.2641121802107988 0.1490050366089257 0.8815496586958254 1.0 0.956352876949702 25 Q9Y4I1,Q9Y6K9,P50897 3 +Adducted thumb 0.2627603680758846 0.1468142012291468 0.8832786751912607 1.0 0.957320979481506 26 Q86XL3,P42892,Q9NPF4,Q9UIG0,Q8NCH0,P35250 6 +Urinary urgency 0.3343273691186154 0.1439305566636771 0.8855553061765546 1.0 0.9585308927036336 6 Q8WVX9,Q9UBB4,P54886,P20700,P04062 5 +Thick eyebrow 0.251166237142113 0.1431391978371468 0.8861802482686432 1.0 0.9588763584694042 44 P15586,O95831,Q9Y4W2,P98175,P08236,Q8IWS0,Q08J23,Q9UHX1,Q69YQ0 9 +Abnormal thorax morphology 0.2086836975226635 0.1428224579637103 0.8864304000185073 1.0 0.9589203358271584 222 Q03164,P15586,O96028,P46777,Q15125,Q7RTS9,P49773,P35250,Q8N201,Q07020,O95831,Q9Y6K9,P98175,P00813,Q7LGA3,Q14807,P06753,Q08J23,Q9BTW9,Q9BUK6,Q9BV10,Q9Y487,O75718,P08236,O60828,Q8NCH0,Q9UHX1,O75844,Q01968,O75531,P50542,P61313,Q92766,Q9UIG0,Q9H9E3,P16278,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 42 +Knee flexion contracture 0.2608106083976801 0.1424594165453245 0.8867171332714967 1.0 0.9590038560925426 27 P06753,Q7LGA3,O95425 3 +Impairment of activities of daily living 0.2385008180056345 0.1404852188254813 0.8882766303409393 1.0 0.9600099497214828 53 P26358,Q99720,P07602,O43681,O15269,Q9Y6X9 6 +Abnormal circulating nitrogen compound concentration 0.2342665879927442 0.1380639244445013 0.8901898968012874 1.0 0.960940272226602 55 P49257,Q9BUB7,O43772,P40939,P09622 5 +Melanocytic nevus 0.2948573918817123 0.137838556483381 0.8903680115186172 1.0 0.960940272226602 11 Q01082,Q15022,P21912,O75530,P10644,Q06124 6 +Abnormal male reproductive system physiology 0.2538764695720588 0.1375360667395602 0.8906070864726339 1.0 0.960940272226602 35 Q01968,O00170,Q9BZH6,Q13423,Q9UIG0,Q709C8,P09884,P35250 8 +Early onset of sexual maturation 0.2516019133207408 0.13634587376269 0.8915478604467244 1.0 0.961049118526768 42 P49815,O96028,O00170,Q7LGA3,Q9UGU0,Q13045,Q13423,Q9UIG0,P35250 9 +Undetectable visual evoked potentials 0.2754374576128556 0.1358393884652036 0.8919482521516842 1.0 0.9612543324931148 4 P14854 1 +Bulbous nose 0.2489669403562416 0.1352478671359158 0.8924159022382327 1.0 0.9614365703494564 45 Q9UPW6,Q8ND04,P42892,O60828,Q9UGU0,Q8N201 6 +Autoimmune hemolytic anemia 0.3027820197677129 0.1350941097707584 0.8925374672088355 1.0 0.9614365703494564 10 Q05655,P00813 2 +Abnormal epidermal morphology 0.2781867332457472 0.1346649364322464 0.8928767972772205 1.0 0.9615757885030208 17 Q9H4L7,Q06136,O75844 3 +Abnormal carotid artery morphology 0.2811254594309706 0.1332942403179035 0.8939606825157305 1.0 0.9621943873600656 15 Q9UIG0,O75844 2 +Severe infection 0.309880224525596 0.1326016874409874 0.8945083978225647 1.0 0.9624271125608552 9 Q05655,Q9Y6K9,P17812 3 +Axial muscle weakness 0.2735099337748269 0.1311680111226003 0.8956424007125279 1.0 0.9627419605592392 4 P02545,Q9Y281,P11047 3 +Accelerated skeletal maturation 0.2923700623202141 0.1305698909261763 0.8961155623330912 1.0 0.963024402159793 11 Q03164,O75530,O00170 3 +Dyspnea 0.2307720104961813 0.1293443802382615 0.8970851559979136 1.0 0.9634308246787088 95 P49815,P00846,O95831,Q9Y619,Q15165,P07602,P51970,Q9NZJ7,O75844 9 +Progressive visual loss 0.2693693109530839 0.128968975216842 0.8973821979608372 1.0 0.9634308246787088 20 P00846,O00170,P50897 3 +Hypertrophic cardiomyopathy 0.2300289500043796 0.1286348882079616 0.897646558840643 1.0 0.9634308246787088 107 P15586,P00403,Q99797,O75251,P35250,O00170,Q9BUB7,P09622,Q96CU9,P09493,Q9Y6M9,Q86Y39,P40939,P13473,Q9H061,P00846,Q13423,P16278,Q9UIG0 19 +Short palpebral fissure 0.2590123978204557 0.1284956869833169 0.8977567112201645 1.0 0.9634308246787088 26 Q03164,P98175,P55795,Q7Z6Z7,O95602,P07437,P38398,Q9Y619,Q9UHX1,O75844,Q12830 11 +Hypoplastic female external genitalia 0.2807333885978858 0.1281326349624811 0.898044009940562 1.0 0.963513228668062 14 Q9Y619 1 +Abnormality of the voice 0.2233288738739231 0.1265957926933641 0.8992603270931165 1.0 0.9643661005401112 131 Q69YQ0,P52788,Q9NR77,P35250,Q6DKK2,P21333,Q92890,O00170,Q9H0U9,Q15233,Q7LGA3,O75530,P06753,Q12830,O75569,Q9BZH6,P11047,Q9Y487,P09884,O60828,Q06124,O75844,Q9Y6X9,P00846,Q01968,Q15022,P28340,P31040,P54136,Q92766,Q9UIG0,Q13045,Q9UGU0,Q8WXH0,Q96HY6 35 +Abnormal distal phalanx morphology of finger 0.2473947091269261 0.1255655773407189 0.9000758125380515 1.0 0.9650145218989604 45 O75531,Q7LGA3,Q14807,Q8IWS0,P53634,O15111,Q9H9E3,Q6DKJ4,O75844 9 +Abnormal large intestine physiology 0.2609470096164937 0.124692432692821 0.9007670484795663 1.0 0.9655294568831324 24 P06280,P15289,Q92766,P55072,P07602,O43681,Q9NZJ7,Q9BTW9 8 +Upper extremity joint dislocation 0.2718818273119781 0.1191710026454098 0.9051398794443556 1.0 0.9688552919122584 18 Q9Y619,Q14807,Q6DKJ4 3 +Abnormal pulmonary valve physiology 0.250294353271814 0.1186682990873835 0.905538152700847 1.0 0.9690549742604108 34 P00813,Q8TD19,Q9UIG0,P60953,Q9BU61,Q86TI2,P55263,Q06124,P35250,Q6PGP7,Q12830 11 +Abnormality of the intrinsic pathway 0.2782874341190745 0.1180227209654257 0.9060496549736664 1.0 0.9690937145041134 13 P49257,Q9BV10 2 +Abnormality of the inner ear 0.29608733486934 0.1172135646936635 0.9066908179460372 1.0 0.9692346649681668 10 Q9Y619,Q9H9Y6,Q06124,O60220 4 +Cystic hygroma 0.3104184405250428 0.1168670200960928 0.9069654331738888 1.0 0.9692346649681668 8 P61978,Q06124,Q14739 3 +Macrodontia 0.2663128950083842 0.1168528812824959 0.9069766375483196 1.0 0.9692346649681668 20 Q7LGA3,O60828 2 +Ventricular escape rhythm 0.3194168323392939 0.11215983374319 0.9106966761883312 1.0 0.9723020030123608 6 P02545,Q13642,Q8NF91,P50402,Q8WXH0 5 +Atrophy degeneration involving the corticospinal tracts 0.2853551931615375 0.1109826300944177 0.91163012080854 1.0 0.9730716098275856 11 P00846,Q9UIG0 2 +Abnormal venous morphology 0.2549246824161817 0.1089718920368251 0.913224784447703 1.0 0.9738652932006376 28 Q05655,Q92890,P98175,Q9Y487,Q8ND04,Q92990,Q92766,Q7LBC6,P47985,Q9H9E3 10 +Large intestinal polyposis 0.316501090546099 0.1064275575125633 0.9152431295061196 1.0 0.9753359263677552 6 P20585,P21912,Q07864,P28340 4 +Colorectal polyposis 0.316501090546099 0.1064275575125633 0.9152431295061196 1.0 0.9753359263677552 6 P20585,P21912,Q07864,P28340 4 +Irregular vertebral endplates 0.3106083288216157 0.1046192072337842 0.9166779731753458 1.0 0.9764103056140464 7 O15228,Q14807 2 +Abnormal magnesium concentration 0.2871684818870454 0.1027502956021528 0.9181611547392504 1.0 0.976913152044574 5 P05023 1 +Coronary artery atherosclerosis 0.2605960264900596 0.1022429782730467 0.9185638147499318 1.0 0.976913152044574 4 P02545,P34913,P31153 3 +Abnormal esophagus physiology 0.2117593181179768 0.1014776517652716 0.9191712972763082 1.0 0.9769232563498104 210 Q03164,P15586,O96028,Q14108,Q9NR77,O60220,Q92947,Q96F07,O15269,Q9Y584,Q9NZJ7,P35250,P07737,P21333,Q9UEY8,Q9UPW6,Q8IZA0,P06753,P07602,P05067,Q9BTW9,O15118,Q9BV10,O75569,Q99720,Q9BU61,P61916,Q9UHX1,P00846,Q01968,Q86XI2,Q9H7D7,Q9BUF5,Q92766,Q15067,Q13045,Q14739,Q9Y619,Q9UIG0,Q9UBM7,Q69YQ0 41 +Dysdiadochokinesis 0.2701705282238718 0.1013231216485208 0.9192939622238656 1.0 0.9769232563498104 16 O15020,Q9BUK6,O75503,P41440 4 +Intestinal pseudo obstruction 0.3032477378735519 0.1010239190363986 0.9195314726636444 1.0 0.9769488278508588 8 P61978,P21333,P00403 3 +Headache 0.231904000070792 0.0974703838389129 0.9223528524919756 1.0 0.9790373390203556 65 P00846,Q05655,P00403,O00170,P49327,Q92621,Q8NFH4,Q01130,O15382,P06753,Q9NZ08,Q92947,Q8N1F7,Q14C86,P05067 15 +Abnormality of the pinna 0.205852619663153 0.0963108660129044 0.9232736813763658 1.0 0.9791806008301897 222 O96028,P46777,P52788,Q15125,Q9NPF4,Q5SRE5,Q9H9Y6,P35250,Q8N201,Q6PGP7,Q07020,P21333,O00170,P98175,Q13555,Q7LGA3,Q15392,O75530,P36551,Q08J23,Q9BTW9,Q9BV10,P48449,Q8ND04,P42892,O14617,Q96KP1,P09884,O60828,O15111,Q8NCH0,Q9UHX1,O75844,Q9Y4W2,Q01968,P50542,P61313,Q06136,Q92766,Q9UIG0,Q8IWS0,P16278,Q9Y619,Q9UGU0,P10586,Q69YQ0 46 +Unilateral renal agenesis 0.2581224335892433 0.0962228796471411 0.923343559795302 1.0 0.9791806008301897 21 Q86XL3,Q7LGA3,P42695,P60953,Q9UBM7,Q9UHX1 6 +Macular thickening 0.3108586259531768 0.0957821202404595 0.92369361804307 1.0 0.9793249223495788 6 P04439 1 +Hip dislocation 0.2300530451805375 0.0948673165946598 0.9244202169818984 1.0 0.979790231234944 59 O96028,Q01968,P43034,Q9Y487,Q14807,Q9NPF4,P06753,Q9UBM7,Q9UHX1,Q9BTW9,O75844 11 +Weak cry 0.2936868522264338 0.0939658376570459 0.925136294228486 1.0 0.979790231234944 9 P06753 1 +Primary amenorrhea 0.251384761972186 0.0933534090506458 0.9256228030061736 1.0 0.979790231234944 26 Q9BZH6,P49770,A6NHR9,Q9NR50,Q9BUK6,Q13144 6 +Hypodontia 0.243487617201563 0.0932746104752001 0.9256854020380962 1.0 0.979790231234944 43 O96028,Q9Y6K9,Q8ND04,Q15067,Q9UIG0,Q6DKJ4,O75844 7 +Joint stiffness 0.2297130581994609 0.0925543765008612 0.926257590375258 1.0 0.979790231234944 59 P15586,P21333,Q01968,Q15022,O75531,O75530,P08236,Q13045,Q9UIG0,P16278,P35250,O75844 12 +Pneumothorax 0.2984843083173316 0.0911097020888981 0.9274054235568558 1.0 0.9807612346625992 8 P49815 1 +Increased muscle lipid content 0.292192004320051 0.0907064434930259 0.9277258505740762 1.0 0.9808734622493755 9 P06753 1 +Weakness due to upper motor neuron dysfunction 0.2210719641105479 0.0897963402853671 0.9284490564719894 1.0 0.9809960501089816 135 P49815,P00846,O95831,Q9Y6K9,Q9Y619,P00403,Q9BZH6,Q13423,Q9NZ08,P07602,O43681,Q7RTS9,P51970,P49773,Q9UBX3 15 +Tics 0.2803026646354113 0.0895903753117302 0.9286127330376304 1.0 0.9809960501089816 5 Q01082,Q9UHX1 2 +Blue sclerae 0.2542262634842067 0.0894816669138177 0.9286991228145548 1.0 0.9809960501089816 23 Q9Y6K9,Q9Y2D4,O75718,P62266,Q8NCH0,Q9Y3B2,Q9H9E3,Q6DKJ4 8 +Astrocytoma 0.2974502316668596 0.0890218064442336 0.9290645798853194 1.0 0.981073253966438 8 P49815,P48735,P52701 3 +Lower extremity joint dislocation 0.2305611301118063 0.0882267311569754 0.9296964717642292 1.0 0.9813700994614568 73 O96028,Q01968,P43034,Q9Y487,Q14807,Q15125,Q9NPF4,Q92766,P06753,Q9UIG0,Q9UBM7,P35250,Q9UHX1,Q9BTW9,O75844 15 +Abnormal hair morphology 0.2134073709407501 0.0862085229695255 0.9313006555836968 1.0 0.9823837521563912 325 Q03164,P15586,O96028,P00403,P46777,P52788,Q15125,Q5SRE5,Q96F07,O75251,Q9H9Y6,Q9NYB0,Q8N201,Q6PGP7,Q13126,Q00535,Q07020,O95831,Q9Y6K9,O00170,P98175,Q13555,Q9UPW6,Q9Y4I1,P00813,P61586,Q7LGA3,Q5KU26,O75530,P36551,Q08J23,Q96CU9,Q9BTW9,Q00839,Q9BV10,P48449,Q9BUK6,Q05655,Q9BZH6,O43924,Q8IYI6,Q9Y487,O14617,P08236,Q9BU61,P09884,O60828,Q9UHX1,O75844,P49327,Q9Y4W2,Q01968,O75531,P61313,Q9H7D7,Q06136,Q13045,Q8IWS0,P53634,P16278,Q9H9E3,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 67 +Abnormal pons morphology 0.260226672583185 0.0855708074662911 0.9318076055827028 1.0 0.9826424600292828 19 Q9Y3B2 1 +Abnormal periventricular white matter morphology 0.2438653230436067 0.0853598726909358 0.9319752936393088 1.0 0.9826424600292828 39 O96028,P07602,O43681,O95298,Q9NZJ7,Q9UHX1,Q9Y6X9 7 +Abnormality of carpal bone ossification 0.3044631719843059 0.0844278666764135 0.9327162519737442 1.0 0.9829708232290646 6 O75369,Q15125 2 +Optic atrophy 0.219903042888344 0.0826117461709236 0.9341602611099726 1.0 0.98381304995406 183 O96028,P00403,P26358,Q15125,O43681,O60220,Q9NZJ7,Q15043,P49815,Q9Y6K9,Q9Y4I1,P61586,Q5KU26,P07602,P41440,Q86Y39,P50897,Q9H061,P00846,P50542,Q15067,P16278,Q6PJG6 23 +Joint contractures involving the joints of the feet 0.2880533860422122 0.0819537874585453 0.9346834620437026 1.0 0.9841376134745864 9 Q8IWS0 1 +Low hanging columella 0.2808096013164247 0.0806451895547722 0.9357241271506213 1.0 0.9844219149178244 10 P55795,Q7LBC6,Q96J02,O60828,Q9BTW9,P35222 6 +Long fingers 0.2232824763353908 0.0805146258616575 0.9358279642442292 1.0 0.9844219149178244 88 Q03164,O96028,P52788,Q15125,Q9NPF4,O00170,Q9UPW6,O75530,Q9H4L7,Q9BV10,P42892,Q8NCH0,O60828,Q9UHX1,Q9Y4W2,Q06136,Q92766,Q8IWS0,P53634,Q9UGU0 20 +Osteomalacia 0.2490066225165487 0.0797887220021107 0.9364052942641744 1.0 0.9844219149178244 4 Q9Y617,Q01968,O43175 3 +Narrow nose 0.2968155795024833 0.078368574861297 0.937534870256258 1.0 0.9849423503861882 7 Q9Y4A5,Q07864,O75431,Q9UPW6 4 +Generalized hyperreflexia 0.2480132450331041 0.0780165444927637 0.9378148925022958 1.0 0.9849423503861882 4 P13639,P19447,P18074 3 +Delayed ability to walk 0.2284342741509567 0.0771026071409281 0.9385419189783606 1.0 0.9853253523237676 62 P48449,Q86XI2,Q99720,Q6PJG6,Q96N66,Q9UGU0,Q10713 7 +Spastic tetraplegia 0.2423995024815957 0.0768875436610749 0.938713006930505 1.0 0.9853253523237676 38 Q13057,Q01082,P42356,Q9UEY8,Q86XL3,P08243,P15289,P34897,O43681,Q9Y3Z3,Q96KP1,P16278,P00387,P49792 14 +Abnormality of the hallux 0.2287906806022707 0.0765184052399552 0.9390066716384164 1.0 0.9853253523237676 53 O96028,Q9UPW6,Q7LGA3,P61586,Q15125,Q9UIG0,Q9UGU0,Q9UHX1,Q6DKJ4 9 +Antenatal onset 0.2633080066887455 0.0762050609496932 0.9392559563444612 1.0 0.9853253523237676 12 O95298 1 +Spastic dysarthria 0.2899912199339536 0.0746394177200514 0.940501610773484 1.0 0.9861800395212454 8 Q8WVX9,Q8N0X7,Q86SX6,Q9H2M9 4 +Renal hypoplasia aplasia 0.2209469888027358 0.0731316944319005 0.9417013206671444 1.0 0.9872118517392396 86 Q86XL3,Q9BZH6,O43924,Q86XI2,P61313,Q7LGA3,Q15392,Q92766,P35250,P42695,Q13045,Q9BU61,Q9UBM7,O60828,Q9UIG0,Q9UHX1,Q6PGP7,Q07020 18 +Increased circulating prolactin concentration 0.2968216350427944 0.071846083939723 0.9427243978749156 1.0 0.9873506920004952 6 O00170 1 +Tooth malposition 0.2229801430863819 0.0718404066489156 0.9427289160224388 1.0 0.9873506920004952 89 P52788,Q9H9Y6,P35250,O00170,Q9UPW6,P61586,P06753,Q9BTW9,P08236,O75844,Q01968,P28340,O75531,Q9H7D7,P16278,Q14739,Q9UIG0,Q9UBM7,Q6DKJ4,Q69YQ0 20 +Meningocele 0.2766819602627859 0.0717805657393336 0.9427765392115126 1.0 0.9873506920004952 10 P21333,Q10713,Q92766 3 +Truncal obesity 0.2592901102002082 0.0716136751094342 0.9429093568561882 1.0 0.9873506920004952 17 Q9Y4W2,Q8IWS0,P31751,Q8NI27,Q10713,Q12830 6 +Aplasia hypoplasia of the fibula 0.2923625533477135 0.0706968920109529 0.9436389944658592 1.0 0.9878855621386636 7 Q9Y5S9,P21333,O75369,Q8NCM8 4 +Brain imaging abnormality 0.2403230279897718 0.0683970471006818 0.9454695723997992 1.0 0.9889859978228384 34 P00403,Q9UPW6,Q9H7D7,P55072,P07602,Q9BU61,Q93009,Q9NZJ7,Q9BV10 9 +Blepharophimosis 0.2360473747575497 0.0657186609982549 0.9476018152018072 1.0 0.990448391911092 46 Q7LGA3,P61586,Q9UGU0,Q9UIG0,Q8IWS0,Q08J23,Q9Y619,P35250,O75844 9 +Broad based gait 0.2466921008832223 0.0652097056314103 0.9480070336020988 1.0 0.9906457061179924 24 Q03164,Q01082,P98175,Q9UPW6,P50542,Q9H7D7,P52788,P55072,O14773,P27708 10 +Abnormal toenail morphology 0.2346185177123664 0.0632605665541398 0.949559016169894 1.0 0.9914237245458736 47 Q9Y6K9,O00170,O75530,Q08J23,Q14739,Q9UIG0,O75844 7 +Aplasia hypoplasia involving bones of the upper limbs 0.2189265101832548 0.063186487242129 0.9496180048960255 1.0 0.9914237245458736 136 Q03164,O96028,Q7RTS9,Q07020,O95831,Q9Y6K9,P98175,Q13555,Q9UPW6,Q14807,Q08J23,Q9BV10,O15111,Q9UHX1,O75844,Q9Y4W2,P50542,P61313,Q8IWS0,O00116,Q14739,Q9Y619,Q9H9E3,Q9UBM7,Q6DKJ4,Q69YQ0 26 +Nasal speech 0.2391902885414991 0.0618775298808393 0.9506603617585144 1.0 0.992059388000164 35 Q92890,Q15233,Q7LGA3,Q9Y487,P52788,Q92766,P06753,O60828,Q9UGU0,Q12830 10 +Nail dystrophy 0.2449719647068179 0.0598436971178531 0.9522801226524172 1.0 0.9924134636405 29 Q9Y6K9,O75844,O60828 3 +Myoclonic seizure 0.2275781766994461 0.0596619409103901 0.9524248844644304 1.0 0.9924134636405 52 P00846,Q8IYI6,P43034,O14617,P07602,P16278,Q6PJG6,O75503,Q96N66,Q9Y619,Q9NZJ7 11 +Decreased facial expression 0.2446819544931662 0.0576136420466429 0.9540563829420644 1.0 0.9933385042597428 24 P35270,Q15043 2 +Abnormal circulating glutamine family amino acid concentration 0.2794347819531718 0.0563020782947671 0.9551011632232098 1.0 0.9939179018440434 8 O95298 1 +Abnormal morphology of the abdominal musculature 0.2676099107459061 0.0538040687760938 0.9570912678027776 1.0 0.9955924392575712 10 Q06124,Q69YQ0,O00462,Q8NCH0 4 +Chronic kidney disease 0.2373555574191446 0.0522089281826859 0.9583622189765664 1.0 0.9964723449721196 37 P49815,Q05655,Q01968,P11047,Q92621,Q8NFH4,Q9NPF4,P50336,Q8N1F7,Q92947,Q14C86,Q27J81 12 +Abnormal enzyme coenzyme activity 0.2179748252201951 0.0498346504290701 0.9602541539278088 1.0 0.9982019674148492 180 P00813,Q5JRX3,O43772,P07602,P09622,O15382,P55263,P41440,O15118,Q9BV10,Q8N511,Q14566,P40939,P10619,P61916,P00846,Q9HC07,Q15067,P16278,Q14739,Q9Y619 21 +Juvenile cataract 0.2785769718200525 0.0493850002026559 0.960612481680348 1.0 0.998285937167142 7 Q8WVX9,Q9H2P0 2 +Plagiocephaly 0.2378729092700005 0.049043933489197 0.9608842841830176 1.0 0.998285937167142 31 Q01082,Q9H2P0,Q15233,Q9Y3Z3,Q96F07,Q93009,Q10713,Q9UGU0,Q01105,Q08209,Q9BTW9,Q9BV10 12 +Fatty replacement of skeletal muscle 0.280318091451288 0.048253000745752 0.9615146108610664 1.0 0.998285937167142 6 P22626,P09651,P55072,P51114,Q7Z406 5 +Smooth philtrum 0.2248458827648921 0.0481989181645025 0.9615577123669784 1.0 0.998285937167142 69 Q9UPW6,Q7LGA3,Q9Y487,Q8ND04,Q96KP1,Q08J23,Q9Y3B2,Q9UGU0,P10586,Q00839,Q69YQ0 11 +Nevus 0.239761258983475 0.0470687836626222 0.9624584067794392 1.0 0.9989052444057804 30 P49815,Q15022,Q8TD19,P11802,O75530,Q9UIG0,P35250,P60953,Q9Y5S9,Q06124,Q9NYB0,Q9UHX1,Q6DKJ4 13 +Poor suck 0.2399019614499037 0.0460659109422923 0.9632577162775188 1.0 0.9995081766951268 26 P11047,P50542,Q15233,P22695,P40939,Q9BU61,Q93009,O60828,Q9UBM7 9 +Fetal onset 0.2776673293571844 0.0449071035098803 0.9641813547763992 1.0 0.9997866019056588 6 P27635,Q9NSD9,Q7L590,P62140,O95235 5 +Abnormality of the scrotum 0.2319451147299629 0.0442747925745897 0.9646853645771348 1.0 0.9999862870480652 46 Q9Y619,P46977,Q9BV10,Q01082,Q69YQ0,Q7Z6Z7,Q9H0U9,P07437,Q7LGA3,Q8IWS0,Q9UBM7,Q9H9Y6,Q9UGU0,Q9H488,Q12830 15 +Abnormal muscle fiber protein expression 0.273781902552198 0.0428162352686618 0.9658480219845572 1.0 0.9999862870480652 7 P02545,Q13642,Q9BTV4,Q8NF91,P50402,Q8WXH0 6 +Abnormality of the radial head 0.2703618733438173 0.042391596672164 0.9661865272132908 1.0 0.9999862870480652 8 P21333,Q14807 2 +Heat intolerance 0.2492286886144253 0.0422616407285008 0.9662901242134534 1.0 0.9999862870480652 5 P61978,Q9H488 2 +Abnormal jaw morphology 0.210442885532991 0.0421987549239929 0.9663402551045646 1.0 0.9999862870480652 279 O96028,P46777,Q15125,Q9NPF4,Q5SRE5,Q7RTS9,Q9Y3B2,P35250,Q8N201,Q00535,Q07020,Q13057,O00170,P98175,Q9UPW6,Q9BUB7,Q7LGA3,Q2TAA5,Q15392,O75530,P06753,Q08J23,Q9BTW9,Q00839,Q9BV10,Q9BUK6,O43924,Q8ND04,O95425,O14617,P09884,O60828,O15111,Q8NCH0,Q9UHX1,O75844,Q86XL3,Q9Y4W2,Q01968,Q86XI2,O75531,P50542,P28340,P61313,Q9H7D7,Q92766,Q9UIG0,Q13045,Q9H9E3,P16278,Q6PJG6,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q6DKJ4,Q69YQ0 57 +Aplasia hypoplasia involving the metacarpal bones 0.2411341416792626 0.0412262645839306 0.967115515357816 1.0 1.0 23 Q14739 1 +Abnormal circulating dicarboxylic acid concentration 0.2347047084865197 0.0405180287915332 0.967680133946358 1.0 1.0 39 P43034,P22695,P36551,Q92947,Q14739,P55263,P41440,P00390 8 +Pseudobulbar paralysis 0.2639397441704554 0.033547886031995 0.9732376797713848 1.0 1.0 8 Q15233,P42356,P54136 3 +Primary gonadal insufficiency 0.2633739268197358 0.0328076097579156 0.973828009771604 1.0 1.0 8 P49770,Q13144 2 +Ulnar deviation of finger 0.2628598402143146 0.0321404060481568 0.9743600806760266 1.0 1.0 8 Q9Y2D4,Q9UBM7,Q9H2M9 3 +Abnormal eyelid physiology 0.2663322276515401 0.0319245747538351 0.9745322008059648 1.0 1.0 6 Q9H9Y6 1 +Cerebellar vermis atrophy 0.2422925462319846 0.0306300209541439 0.9755646001179824 1.0 1.0 12 Q9UHD1,Q10713,P07437 3 +Abnormality of the humeroradial joint 0.2583174617657415 0.0305764469627191 0.9756073259662944 1.0 1.0 9 P21333,Q14807 2 +Turricephaly 0.2483717610062146 0.0301942799937458 0.975912110356962 1.0 1.0 11 P50542 1 +Long toe 0.2565013218161249 0.0280712866125499 0.9776052950091444 1.0 1.0 9 Q9UHX1 1 +Abnormality of the abdominal wall 0.2169024062092779 0.0250035179400222 0.98005215757664 1.0 1.0 117 P43034,Q96HY6,P60953,P35250,Q6PGP7,P21333,Q9Y6K9,Q9UPW6,Q9BUB7,O75530,P51970,Q9Y487,P08236,O15111,Q8NCH0,Q9UHX1,O75844,Q01968,Q15022,P07437,O00462,Q92766,P16278,Q6PJG6,Q14739,Q9UIG0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 30 +Abnormal duodenum morphology 0.2402915671933116 0.0245518703323747 0.9804124096241568 1.0 1.0 13 O43684,Q8NCH0,P98175,Q7LBC6 4 +Limitation of joint mobility 0.2191876293016086 0.024010236160043 0.980844443786718 1.0 1.0 98 P15586,Q7RTS9,P35250,P21333,Q7LGA3,O75530,Q14807,P06753,P11047,O95425,P08236,Q9H6K4,O75844,Q01968,Q15022,O75531,Q13045,P55072,P16278,Q9UIG0 20 +Truncal ataxia 0.240000607931336 0.0221814483632935 0.9823032160119808 1.0 1.0 18 O15020,P34897,P31040,P14854,P13639,O75503,Q9BUK6 7 +Abnormality of the peritoneum 0.2389641385096712 0.0220399732996946 0.9824160691914684 1.0 1.0 19 P52565,Q92621,Q8NFH4,Q8N1F7,Q14C86,Q27J81 6 +Abnormal cns myelination 0.2138196044648109 0.0206640487713216 0.9835136478167648 1.0 1.0 131 O43681,Q5SRE5,O75251,Q9Y3B2,Q9NZJ7,Q9Y584,O95831,Q7LGA3,P07602,Q96CU9,Q9BTW9,Q9Y6M9,Q86Y39,Q8IYI6,O14617,P78527,Q99720,Q96KP1,Q9Y6X9,Q9H7D7,Q15067 21 +Atrophy degeneration affecting the brainstem 0.2362449971182165 0.0199447403032423 0.9840874546321208 1.0 1.0 12 P26358 1 +Posteriorly rotated ears 0.2183679111429778 0.0189751212965707 0.9848609521657764 1.0 1.0 108 O96028,Q9HC07,O43924,P50542,Q7LGA3,Q8ND04,O75530,Q15392,P42892,Q08J23,Q9Y619,Q9UGU0,Q10713,Q6DKJ4,Q69YQ0 15 +External genital hypoplasia 0.2168424420001654 0.0185837468637603 0.9851731687221016 1.0 1.0 115 Q9H7N4,Q9H936,P43034,Q15813,A6NHR9,O43172,Q92620,Q9H9Y6,P35250,O15294,P27635,P46977,Q9UPW6,Q9H0U9,O75530,Q9Y3Z3,Q9BV10,P48449,Q01082,Q9BZH6,Q7Z6Z7,P42892,P78527,P09884,O60828,Q9H2M9,Q06124,O75844,Q6P2Q9,Q15022,P07437,O75312,Q8IWS0,Q07864,Q93009,Q8NI27,Q9Y619,Q9UIG0,Q9UBM7,Q10713,Q6DKJ4 41 +Secondary microcephaly 0.219878037524866 0.0178698819651848 0.9857426558866352 1.0 1.0 66 Q9HC07,Q86Y39,Q9Y487,Q5KU26,P50897,Q96KP1,Q6PJG6,Q96CU9,Q9UHX1,Q15043,Q9BV10 11 +Abnormal 5th finger morphology 0.2185237240544719 0.0170801995299564 0.986372635095335 1.0 1.0 102 Q03164,P43034,Q15125,Q7RTS9,P35250,Q9UPW6,Q08J23,Q9BV10,O43924,P09884,O60828,Q9UHX1,Q8NFH4,Q9UIG0,Q13045,Q6PJG6,Q14739,Q9Y619,Q9UGU0,Q9UBM7,Q10713,Q6DKJ4,Q69YQ0 23 +Abnormal atrioventricular valve morphology 0.2279247324186979 0.0164853316391861 0.9868472041555448 1.0 1.0 33 Q92890,P21333,Q15233,P46777,Q92766,Q9UIG0,P06753,P35250,Q6DKJ4,O75844 10 +Abnormal cry 0.232123666420525 0.0132585751949786 0.9894214974867594 1.0 1.0 12 P06753 1 +Abnormal shape of the palpebral fissure 0.2433597711219656 0.0119648305104061 0.990453674234496 1.0 1.0 9 Q9UHX1,P28482,P38398 3 +Macular degeneration 0.2303181433784714 0.0104780149915353 0.9916399065847744 1.0 1.0 12 P50897 1 +Abnormal urine protein level 0.2153999942678244 0.010304893426615 0.9917780301507408 1.0 1.0 54 P00403,Q01968,P11047,P06280,Q14108,Q92621,Q8NFH4,Q9NPF4,Q9UIG0,P09601,Q8N1F7,Q14C86,P35579,P35250 14 +Arthrogryposis multiplex congenita 0.2269694633850845 0.0083141222906594 0.9933663666123188 1.0 1.0 36 P06753,Q15392,O75844 3 +Telangiectasia of the skin 0.2297010912756042 0.0053166232787096 0.9957579683548744 1.0 1.0 21 P06280,Q8IZA0,Q9Y6K9,Q14739 4 +Renal insufficiency 0.2093944015822358 0.0022749460223492 0.9981848572577832 1.0 1.0 83 P49815,Q05655,P49327,Q01968,P11047,P06280,Q14108,Q92621,Q8NFH4,Q9NPF4,P35250,Q9NZ08,P50336,Q92947,P35579,Q9UIG0,Q10713 17 +Syndactyly 0.2092551367654347 0.0013033351170915 0.9989600893269336 1.0 1.0 83 Q9Y6K9,P98175,O43924,P61586,O75530,Q15125,Q08J23,O15111,Q9Y619,Q6DKJ4,Q69YQ0 11 +Echolalia 0.2288940218947389 0.0002326127521655 0.999814401878075 1.0 1.0 7 Q9UHX1,P55072 2 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f1122b5e123f35b80fdb534ed65ef1937d4904b9 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 4th finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil count", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcification of the carpal bones", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal coronary sinus morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lacrimal punctum morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the dental root", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal tarsal ossification", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the eustachian tube", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent lacrimal punctum", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lens", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of cartilage", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac rhabdomyoma", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical incisor", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dacryocystitis", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the bladder", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked horizontal nystagmus", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Halitosis", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the primary teeth", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Imbalanced hemoglobin synthesis", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Increased vldl cholesterol concentration", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular iliac crest", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "Ivory epiphyses", "Ivory epiphyses of the phalanges of the hand", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the 5th finger", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Knee pain", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens luxation", "Lens subluxation", "Lenticonus", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megacystis", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncommunicating hydrocephalus", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic endocrine tumor", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid hyperplasia", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Percussion myotonia", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Photosensitive tonic clonic seizure", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Popliteal pterygium", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Reflex seizure", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rhizomelic arm shortening", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged fingernail", "Ridged nail", "Rieger anomaly", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of finger phalanx", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Silver gray hair", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Small thenar eminence", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic dysplasia", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thymus hyperplasia", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Wide pubic symphysis", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP9", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG12", "ALG14", "ANAPC1", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARPC1B", "ARSA", "ARVCF", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATP1A1", "ATP2A2", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATRX", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDHA", "BCS1L", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRCA1", "BRD4", "BUB1B", "BUB3", "BUD23", "C12orf57", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CAPN5", "CARS", "CAST", "CBL", "CCDC115", "CCDC22", "CCDC47", "CCNK", "CCT5", "CD2AP", "CD3EAP", "CDC40", "CDC42", "CDC45", "CDC73", "CDH2", "CDK4", "CDK5", "CDK6", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHORDC1", "CHST14", "CHUK", "CISD2", "CLCC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "CNP", "COA7", "COASY", "COG4", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX15", "COX2", "COX4I1", "COX5A", "COX6B1", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDHD2", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIP2B", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJB11", "DNAJC13", "DNAJC3", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DOCK7", "DPAGT1", "DPF2", "DPM1", "DPP9", "DSG2", "DSP", "DYM", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S3", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC6B", "EXOC7", "EXOC8", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FAH", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FSCN1", "FTO", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GCLC", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GLUL", "GM2A", "GMPPA", "GMPPB", "GNAI2", "GNAI3", "GNB1", "GNPAT", "GNS", "GOT2", "GPD2", "GPHN", "GPI", "GPRASP2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GUSB", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HEXIM1", "HIBCH", "HINT1", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFRD1", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IGHMBP2", "IKBKG", "INF2", "INTS1", "INTS8", "IQCB1", "IRF2BPL", "IRS4", "ISCU", "ITCH", "ITM2B", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KLC2", "KMT2A", "L2HGDH", "LAMC1", "LAMP2", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LSS", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MANBA", "MAP1B", "MAP2K1", "MAP2K2", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED23", "MED25", "MESD", "MFN2", "MGME1", "MIA3", "MICU1", "MIF", "MIPEP", "MMAB", "MOCS1", "MOGS", "MORC2", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MYH14", "MYH9", "MYLK", "MYO5A", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCDN", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NELFA", "NEMF", "NFS1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NR2F1", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE3", "NSUN2", "NT5C2", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PAPSS2", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDK3", "PDXK", "PEPD", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PQBP1", "PREPL", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRPS1", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QRSL1", "RAB11B", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF213", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS29", "RPS6KA3", "RPS7", "RPSA", "RREB1", "RTN4IP1", "SAMHD1", "SAR1B", "SARS", "SARS2", "SATB2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SELENBP1", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC39A14", "SLC9A3R1", "SLC9A6", "SLTM", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMG8", "SMN1*", "SMPD4", "SMS", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPART", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SRCAP", "SRP54", "SRP72", "SRSF2", "SSBP1", "SSR4", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK4", "STT3A", "STT3B", "STUB1", "STX3", "SUCLA2", "SUCLG1", "SUZ12", "SVIL", "SYNE1", "SYNE2", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBL2", "TCF20", "TCOF1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFG", "TFRC", "THG1L", "THOC2", "THOC6", "TIA1", "TIMM22", "TIMM50", 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0000000000000000000000000000000000000000..9e139ea9d64b4d2f1f6b7c4ea524f2e18859ae32 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Lysosome 24 48 2.8598771474426905 0.0042380515131585 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 0.0013677912764436 4.553595339527414e-06 9.1197401809712e-08 1.3689791195026063e-09 +Glycerophospholipid metabolism 7 15 2.512575755821494 0.0119853369227436 5.553398058252427 16.104368932038835 0.8448777148315795 0.3373638196000335 3.045697762577092 2.514285464673758 1.2272389207362138 0.3056726473181033 0.2336798458054532 0.4072036678679048 0.3738517588653947 0.0042301612836837 +Dilated cardiomyopathy 2 7 2.495780033641504 0.0125680510023307 3.0097087378640777 8.393203883495145 0.4535126033788805 0.4859001261794073 1.6428435307790814 1.6853890758730747 0.9621453761461582 0.3132641846990659 1.0 0.3467918934582977 0.0884797465964613 0.3610395035532395 +Hypertrophic cardiomyopathy hcm 2 7 2.495780033641504 0.0125680510023307 3.429611650485437 9.101941747572816 0.6486134300733651 0.4298239576137608 1.8675556020784376 1.719193792909202 1.0005513529453438 0.3180395638112931 1.0 0.3339976348230559 0.0793607883255565 0.3340933889960909 +Apoptosis 7 16 2.1861664110183345 0.0288034327040282 4.643203883495145 18.20873786407767 0.1736799529314038 0.6273242179757177 3.154035391319136 4.106603888177133 0.7370235923699673 0.284300288058217 0.2919842266274133 0.4925597827158772 0.2366877859381625 0.052504971472103 +Base excision repair 6 12 2.1209573951834537 0.0339253879340901 5.786407766990291 16.211165048543688 -0.2730268248762191 0.5152500921911025 3.196328249777864 2.273009980360234 1.0166543179529104 0.3267952106522383 0.1541506060207377 0.2802926639431586 0.0474710620888575 0.0053527619374205 +Adherens junction 2 22 1.9800960912133423 0.0476927322975797 5.798543689320389 23.155339805825243 -0.0755005182068188 0.6586102317692263 5.016061369796722 2.9004762968536166 0.741215920019997 0.2941115658302539 0.0425713267043903 0.1355867800667393 0.2176044663565646 0.6382073330630182 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f8cce1c00983b2bea067a913b3e94f19bf22143e --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 180, + "title": "Average number of proteins per term", + "value": 15.86111111111111 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..228a76742d088925f0ba9fda2faf30b12c9cff90 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..44ec44cf0d497c76084341bd5ea6f10cd2b93fe7 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,95 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Primary immunodeficiency 0.9463931171409674 4.013461477699449 5.9834771282130106e-05 0.0107127860348652 0.0026925647076959 2 P00813 1 +Alpha linolenic acid metabolism 0.8503806686527571 3.166002288341796 0.0015454957786418 0.2430093916670547 0.034773655019441 3 O15254,Q15067 2 +Renin angiotensin system 0.892566866067378 2.996910332985428 0.0027273092039761 0.3883446543360377 0.0545461840795225 4 P10619 1 +Pantothenate and coa biosynthesis 0.7907355156461655 2.883670956084184 0.0039306922894986 0.5078239481278044 0.069349933851686 3 O15382 1 +Lysosome 0.5290651026816126 2.8598771474426905 0.0042380515131585 0.5344195402751938 0.069349933851686 48 P15586,P11717,Q14108,Q8NCC3,O43681,Q99538,Q9NZJ7,Q9Y2T2,Q93050,P06280,P07602,O15118,Q99523,Q9Y487,O14617,P08236,P50897,P10619,P13473,P61916,Q9UMR5,P53634,P16278,O75503 24 +Cytokine cytokine receptor interaction 0.6710787557908726 2.6413401576985485 0.008257876310894 0.7752100933112716 0.1238681446634104 2 P49327 1 +Glycerophospholipid metabolism 0.6974115657505976 2.512575755821494 0.0119853369227436 0.8858672724588676 0.1396986956856365 15 Q6P1A2,Q9HCL2,Q8NCC3,P35790,Q6UWP7,Q96N66,O14735 7 +Dilated cardiomyopathy 0.8820388426397747 2.495780033641504 0.0125680510023307 0.8973659426140356 0.1396986956856365 7 P09493,P67936 2 +Hypertrophic cardiomyopathy hcm 0.8820388426397747 2.495780033641504 0.0125680510023307 0.8973659426140356 0.1396986956856365 7 P09493,P67936 2 +Allograft rejection 0.7643445198025283 2.4167254719799267 0.0156608236135191 0.9416476109170572 0.1396986956856365 4 P04439,P10321 2 +Autoimmune thyroid disease 0.7643445198025283 2.4167254719799267 0.0156608236135191 0.9416476109170572 0.1396986956856365 4 P04439,P10321 2 +Graft versus host disease 0.7643445198025283 2.4167254719799267 0.0156608236135191 0.9416476109170572 0.1396986956856365 4 P04439,P10321 2 +Ether lipid metabolism 0.7496688741721772 2.347647823751053 0.0188923748460023 0.9677152676614384 0.153111961870303 4 Q15102,P43034,O00116 3 +Apoptosis 0.6309634671552924 2.1861664110183345 0.0288034327040282 0.994808594309524 0.1921731767872891 16 P49327,O95831,O94919,Q9Y6K9,P31751,O15111,Q9UHD1 7 +Base excision repair 0.6553143150960876 2.1209573951834537 0.0339253879340901 0.997995895048245 0.2180917795762939 12 P27695,P09874,P28340,Q9NR33,P09429,Q9NRF9 6 +Adherens junction 0.5395314409313596 1.9800960912133423 0.0476927322975797 0.999848686466568 0.2960238556401501 22 Q9UQB8,P61586 2 +Dna replication 0.5034370435464569 1.9553876883227057 0.0505373281793108 0.9999116877159276 0.3032239690758653 27 P28340,P33991,Q14566,Q9NR33,P09884,P41440,Q9NRF9,P35250 8 +Nicotinate and nicotinamide metabolism 0.7201553368864829 1.9374819329429411 0.0526864597805438 0.9999412680971502 0.3059213793708999 5 P43490 1 +Ecm receptor interaction 0.6002293576900128 1.9107403521417388 0.0560379564108812 0.9999689675742226 0.3140636176680368 3 P11047 1 +Glycine serine and threonine metabolism 0.7154160877525859 1.8730033263744092 0.0610679256576738 0.999988138175302 0.3140636176680368 8 P09622,P34896,P32929,P23378 4 +Cysteine and methionine metabolism 0.5727478984620049 1.8321747634465768 0.0669253874822422 0.999996154550058 0.3204898934028181 16 Q13126,O43865,P26358 3 +Retinol metabolism 0.6421213036129949 1.8246676461245468 0.0680511984601657 0.9999969056477398 0.3204898934028181 4 Q6NUM9 1 +Regulation of autophagy 0.6406629435644806 1.817382542838198 0.0691585588866789 0.9999975017967168 0.3204898934028181 4 Q99570,Q9NT62 2 +Cardiac muscle contraction 0.5125806114576468 1.7890839913928838 0.0736012899122944 0.999998944083682 0.3312058046053249 22 P08574,P20674,P00403,P14406,O14949,P05023,P22695,P06753,P09493,P31930,Q9UDW1,P67936 12 +Olfactory transduction 0.5656518896164334 1.7225540473112328 0.0849692010419507 0.999999885599428 0.3528791849764285 3 Q13555 1 +Type i diabetes mellitus 0.6730137122698012 1.718418042883261 0.0857203916427229 0.9999999013207034 0.3528791849764285 5 P04439,P10321 2 +Limonene and pinene degradation 0.7009727895354505 1.7004071301950996 0.0890543715761222 0.9999999488739684 0.3528791849764285 7 P30837 1 +Tryptophan metabolism 0.5653953887981721 1.6911553499604497 0.0908071361896651 0.9999999638520812 0.3528791849764285 14 P30837,Q9BWD1 2 +Sphingolipid metabolism 0.6047312918973899 1.6893623034217151 0.0911500204218058 0.9999999662249248 0.3528791849764285 11 P06280,Q06136,O43681,P16278,O15269 5 +Valine leucine and isoleucine degradation 0.4448659156776917 1.684212149458163 0.0921406760771785 0.999999972245048 0.3528791849764285 33 Q9BWD1,P11182,O15382,P09622,P30837 5 +Pyruvate metabolism 0.462222107014125 1.6319552727411488 0.1026889088388667 0.999999996613536 0.3772245630815513 27 P09622,Q9BWD1,Q16775 3 +Glycerolipid metabolism 0.5430779049905721 1.517688927834408 0.1290928365998194 0.9999999999843348 0.438428501659764 13 Q9HCL2,P06280,P30837,Q99943,Q6UWP7 5 +Fatty acid metabolism 0.4383761940017612 1.4469295476118964 0.1479166565670353 0.9999999999996932 0.4930555218901178 28 P40939,Q9BWD1,O15254,P30837 4 +Vibrio cholerae infection 0.4838449716825391 1.418848646057635 0.1559431468045222 0.9999999999999442 0.5012458290145358 19 P24390 1 +Calcium signaling pathway 0.4863783276871782 1.289114620057414 0.1973582415725883 1.0 0.6021098895434898 16 P45880,Q9UHD1,Q13555,P21796 4 +Cytosolic dna sensing pathway 0.5860150670669986 1.2533326202188926 0.2100846817004544 1.0 0.6091358357167657 8 Q9Y6K9 1 +Nucleotide excision repair 0.4430427226139018 1.2491559835155797 0.2116080276729042 1.0 0.6091358357167657 21 Q9NRF9,P35250,Q9NR33,P41440 4 +B cell receptor signaling pathway 0.5240770694444209 1.2436072977539587 0.2136441289900879 1.0 0.6091358357167657 11 Q9UHD1,Q9Y6K9,P31751 3 +Rig i like receptor signaling pathway 0.5572651277170069 1.2047862144784254 0.2282858431509402 1.0 0.6092312639081177 9 Q13526,Q9Y6K9 2 +Lysine degradation 0.4100167657094551 1.1842370320346591 0.236319246799429 1.0 0.6092312639081177 26 Q9NVH6,Q9BZ95,O96028,Q96KQ7,Q16836,Q9BWD1,P40939,P30837,Q92947 9 +Cell adhesion molecules cams 0.5520844790454017 1.1785497498597268 0.2385775110628687 1.0 0.6092312639081177 9 P10321,P10586,Q92896 3 +Nitrogen metabolism 0.5574915869118172 1.1680176160851174 0.2427996591791803 1.0 0.6092312639081177 5 P00367,P32929 2 +Purine metabolism 0.3473184224623249 1.1390134516355466 0.2546975436897938 1.0 0.6280213406049711 51 Q9NRF9,P00813,P55263,O43924 4 +Porphyrin and chlorophyll metabolism 0.4706365594669076 1.1165677364599802 0.2641791929915926 1.0 0.6425980370065767 14 P08236,P09601,P36551,P30519,P22830 5 +Small cell lung cancer 0.4916719648174097 1.0635043526844523 0.2875532923288704 1.0 0.6901279015892889 11 Q9Y6K9,P31751,O15111,P11047 4 +Drug metabolism other enzymes 0.5450238492130811 1.0546884370661886 0.2915678418234586 1.0 0.6905554148450336 8 P04183,P49915,P08236,P11172 4 +Biosynthesis of unsaturated fatty acids 0.5237809619849241 1.035547132612591 0.3004134669490281 1.0 0.7022652474133126 9 O15254,P40939,Q9NZ01,Q15067 4 +Steroid biosynthesis 0.4796554268213864 0.9970509445097576 0.3187397824491422 1.0 0.7224731394021595 11 P48449,Q16850,Q15800,Q15392 4 +T cell receptor signaling pathway 0.4330337858019314 0.9872192662420284 0.3235351588282693 1.0 0.7224731394021595 17 Q9UHD1,P61586,Q9Y6K9,P31751 4 +Mismatch repair 0.4323748754984949 0.9829716267603474 0.3256214032419677 1.0 0.7224731394021595 17 P35250,Q9UQ84,P41440 3 +Natural killer cell mediated cytotoxicity 0.4384907285924833 0.9518602298622276 0.3411678713843531 1.0 0.7224731394021595 15 P36507,P49327,P63000,P10321,P04439,Q08209,P28482,Q9UHD1,Q06124,P27361 10 +Metabolism of xenobiotics by cytochrome p450 0.5094279819980276 0.8839746919982631 0.3767098747567821 1.0 0.7884625285607066 8 P07099 1 +Pyrimidine metabolism 0.3414588768325378 0.8383110431301778 0.4018560353479867 1.0 0.8037120706959735 40 P04183,P62875,P17812,P32321,P28340,P30876,Q9NR33,P04818,Q07864,P09884,P27708,Q9H9Y6,Q9NRF9 13 +Peroxisome 0.3433676063998961 0.7991155296945787 0.4242234255927262 1.0 0.8252400263301253 33 P50542,Q9NR77,O00116,O15254,Q9UKG9 5 +Sulfur metabolism 0.3978814961933141 0.7891952248066125 0.4299979125093258 1.0 0.8252400263301253 3 O95340,O43252 2 +Colorectal cancer 0.434556755183384 0.7519358017292544 0.4520896666934688 1.0 0.8252400263301253 11 P61586 1 +Butanoate metabolism 0.3903427097209529 0.7491918652464556 0.4537415714801014 1.0 0.8252400263301253 18 P30837,Q9BWD1 2 +Epithelial cell signaling in helicobacter pylori infection 0.3704505550028741 0.734386653864686 0.4627131184905502 1.0 0.8252400263301253 21 Q9Y487,Q9Y6K9,Q93050 3 +Antigen processing and presentation 0.3979747345904941 0.7338316503275404 0.4630513481074592 1.0 0.8252400263301253 16 P04439,P10321,P61289 3 +Type ii diabetes mellitus 0.45178072193983 0.6810299538287847 0.4958525371875968 1.0 0.8452202306302772 9 Q05655,P52789,P28482,P14618,O14654 5 +Selenoamino acid metabolism 0.4177672609217219 0.6635966236248761 0.5069485188644922 1.0 0.8452202306302772 11 O43865 1 +Propanoate metabolism 0.3529453887606706 0.6618194778156343 0.5080869216250248 1.0 0.8452202306302772 23 P30837,Q9BWD1 2 +Glycosaminoglycan degradation 0.4855606935576075 0.6551559185508873 0.5123673724674467 1.0 0.8452202306302772 6 P15586,P16278 2 +Neurotrophin signaling pathway 0.3381975188054363 0.6455488166881508 0.5185715938563522 1.0 0.8452202306302772 29 P61586,Q13555 2 +O glycan biosynthesis 0.4003944437547598 0.6026409075192566 0.546747600512107 1.0 0.8709253813467192 4 Q10472 1 +Systemic lupus erythematosus 0.3865676235757433 0.583657919170393 0.5594504842031809 1.0 0.8830181051446706 12 P62316,P19474,P62318 3 +Regulation of actin cytoskeleton 0.2904733811273747 0.5732477419868466 0.5664769630648241 1.0 0.8830181051446706 52 Q9UQB8,P07737,Q8WUW1,P61586,P35580,Q7L576,Q96F07,P35579,O60879 9 +Proteasome 0.3149722167690472 0.5692914111394642 0.5691583945428409 1.0 0.8830181051446706 35 P60900,P28074,P49721,P61289 4 +Pathogenic escherichia coli infection 0.3417983233815035 0.5622264120589074 0.5739617683440359 1.0 0.8830181051446706 22 O15143,P68371,P07437,P61586,Q9BUF5 5 +Inositol phosphate metabolism 0.39435392339719 0.5446038183325792 0.5860260280569285 1.0 0.8901260287599129 11 Q01968,O00443,P60174,O14735,Q10713 5 +Viral myocarditis 0.3913056256319439 0.5295523731487671 0.5964223231580723 1.0 0.8901260287599129 11 P04439,P10321,P35580 3 +Erbb signaling pathway 0.3580837529861171 0.4640399105306768 0.6426191517829885 1.0 0.9328342525882092 14 P31751,Q13555 2 +Prion diseases 0.4229426920615144 0.4096155644137534 0.6820879776105526 1.0 0.9468892538306176 6 P31948,P27361,P28482,P11047 4 +Glioma 0.3401198740153766 0.3869731447841816 0.6987760894477544 1.0 0.9468892538306176 15 P31751,Q13555 2 +Proximal tubule bicarbonate reclamation 0.4008283488425699 0.3644536611684021 0.7155192708066918 1.0 0.9540256944089224 7 Q9UBX3,P05023 2 +Galactose metabolism 0.3385627216521882 0.3545187745833409 0.7229501364323498 1.0 0.956845768807522 13 P06280,P52789,P16278,P10253 4 +P53 signaling pathway 0.3589473953546053 0.3262909524211629 0.7442042329036294 1.0 0.97070117335256 10 P49815,P49327,P11802,P06493,P14635 5 +Axon guidance 0.2978489525446944 0.2913523170377831 0.7707818788118308 1.0 0.9722443872114582 22 Q9UHD1,P61586 2 +Alzheimers disease 0.2530628637236949 0.27635250584651 0.7822773315833311 1.0 0.9722443872114582 59 Q9Y6M9,P20674,P00403,P08574,P14406,O14949,P49327,P00846,P05067,P22695,O95298,Q9UDW1,P31930,O75251,Q9UHD1,Q92542,Q00535,P51970 18 +Long term potentiation 0.3103639358700774 0.238429638125504 0.8115478822517652 1.0 0.974320924530639 14 Q9UHD1,Q13555 2 +Gnrh signaling pathway 0.3233018367662881 0.2325174722599362 0.8161361181445239 1.0 0.974320924530639 11 Q13557,Q13555 2 +Oxidative phosphorylation 0.2455072238629481 0.2093965109871279 0.8341387162251317 1.0 0.974320924530639 60 Q9Y6M9,P20674,P00403,P08574,P14406,O14949,Q86Y39,P00846,P56134,Q9Y487,P22695,O95298,P31930,O75251,P51970,Q9UDW1,Q93050 17 +Thyroid cancer 0.3136365446939173 0.166443678897417 0.8678078025265707 1.0 0.974320924530639 10 P06753 1 +Rna polymerase 0.3031663461523478 0.1633282964560329 0.8702599556838451 1.0 0.974320924530639 11 Q9H9Y6,P62875,P30876,P62487 4 +Glycolysis gluconeogenesis 0.2602260480129973 0.1441289994396324 0.8853986055522405 1.0 0.974320924530639 30 P09622 1 +Spliceosome 0.2317128546359526 0.1398640627214111 0.888767395926984 1.0 0.974320924530639 103 P52272,Q9UK45,Q9Y333,Q92620,P62318,Q13243,Q9Y3B4,P55769,Q01130,P17844,O75934,P38159,Q09161,Q00839,Q5VTL8,Q15428,Q7L014,P62314,P51991,O60828,P62304,Q9UHX1,Q6P2Q9,P61978,P26368,P62310,Q15365,P41223,Q13595,P62316,P84103,Q96DI7 32 +Arginine and proline metabolism 0.2646339858855543 0.1335390331232696 0.8937670967194584 1.0 0.974320924530639 23 P12532,P52788,P30837,P12277 4 +Vegf signaling pathway 0.2803467558024737 0.1230498201978736 0.9020676468815538 1.0 0.974320924530639 12 P36507,Q08209,P60953,P31751,P28482,Q9UHD1,P27361 7 +Toll like receptor signaling pathway 0.2786741902861072 0.1192084274249077 0.905110230142124 1.0 0.974320924530639 13 Q9Y6K9,P31751 2 +Prostate cancer 0.2739837922016761 0.113838023348588 0.9093661962285964 1.0 0.974320924530639 16 Q9Y6K9,P31751 2 +Nod like receptor signaling pathway 0.2872098111325221 0.0802185763660523 0.9360634159693724 1.0 0.9853299115467078 9 Q9Y6K9 1 +One carbon pool by folate 0.2679351491060623 0.0544130160076984 0.956606108944031 1.0 1.0 10 P34896,P04818 2 +Aldosterone regulated sodium reabsorption 0.2696789113823231 0.035538329001031 0.9716504835437444 1.0 1.0 6 O14654,P28482,P05023 3 +Melanoma 0.2362121886295328 0.0068704240803486 0.9945182378258428 1.0 1.0 10 P36507,Q9NWH9,P11802,P31751,P28482,P27361 6 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e473086038e3e490b39d98d54f42e638e82032d9 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "APP", "APRT", "AQR", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATRX", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BCAT2", "BCKDHA", "BIRC6", "BLVRA", "BPNT1", "BRCA1", "BRK1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CBL", "CBR1", "CCDC6", "CCNB1", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDS2", "CFL1", "CFL2", "CHD8", "CHERP", "CHKA", "CHMP3", "CHORDC1", "CHST14", "CHUK", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COMT", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CROT", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPAGT1", "DPM1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERCC2", "ERCC3", "ERO1A", "ESPL1", "EXO1", "EXOC3", "EXOC7", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBXW11", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLC", "GCLM", "GFPT1", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GLUL", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3A", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GUSB", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HCCS", "HDAC1", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGF2BP1", "IGF2R", "IKBKG", "ILK", "IMPDH2", "IQGAP1", "IQGAP2", "IQGAP3", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LGMN", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LYPLA1", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST3", "MIF", "MMAB", "MOGS", "MPI", "MPST", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NIT2", "NLN", "NLRX1", "NME1", "NME2", "NME3", "NNT", "NPC1", "NPC2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NT5C2", "NUDT12", "NUDT5", "OAT", "OCRL", "OGDH", "ORC2", "ORC5", "OXA1L", "OXCT1", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PATL1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PECR", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PI4KA", "PI4KB", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN1", "PKM", "PKN1", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLXNB2", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "PPA1", "PPA2", "PPAT", "PPID", "PPIE", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4aa71ac85318bb3972229f4a711a2b639e7ebeb21329fd30e9ee92e719ff700a +size 136788 diff --git a/msigdb_reactome/consensus.joblib b/msigdb_reactome/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..20283d3f2597d89826912cac87e69c3c4a7e0a7f --- /dev/null +++ b/msigdb_reactome/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0c8408bc51f9e35529b84898499d1977a1c5c24cdc53e4fcfc136e9748ca6c08 +size 239568 diff --git a/msigdb_reactome/df_merge.tsv b/msigdb_reactome/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2c20803c0c6be748def1920a8d68d424ef089917 --- /dev/null +++ b/msigdb_reactome/df_merge.tsv @@ -0,0 +1,36 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Metabolism of lipids 54 169 4.040991991297019 5.322557630038638e-05 47.21601941747573 182.9902912621359 0.7669400545274999 0.4573741022352977 16.76057659641467 20.451455734561765 1.5920609507025254 0.4091924181498379 0.0001461124316895 0.0011025919903946 1.2410559951846516e-05 8.679397390594288e-08 +Protein localization 20 75 3.325884186603625 0.0008813854199443 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 0.0050563691544293 0.0024184954955513 1.121718976641514e-09 1.2170136278607866e-06 +Metabolism of steroids 16 42 3.3174573432122414 0.0009084078572063 11.16019417475728 45.26699029126213 0.7621248609364072 0.3994790342082778 4.702670999060317 5.049423467032678 1.2014135082145578 0.3371477938402821 0.0015835716265251 0.000456081402069 0.0033082282977481 3.346017298380816e-05 +Mitochondrial protein import 10 36 3.012024785484771 0.0025951140755826 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 0.0029741493546945 0.0024373211620913 1.01581180688848e-05 2.081105380280337e-05 +Cholesterol biosynthesis 6 15 2.92768227110905 0.0034149882837763 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 0.0060718409625537 7.357256485958134e-05 1.694412356328404e-05 0.0001024209024739 +Phase i functionalization of compounds 7 15 2.557141465310796 0.0105536288723484 3.5364077669902914 14.184466019417476 1.0829555250605305 0.2802752482018614 1.63283502003666 1.0657744603346575 1.0337417132355466 0.2758879448139676 0.1747599807978781 0.0538434207197609 0.0022717439932715 0.0004730993907641 +Interferon gamma signaling 5 11 2.414825200446549 0.0157427627066593 3.4174757281553396 12.29126213592233 0.3504356398232429 0.5841793314671695 2.235087678151022 1.9577134867833192 0.8232177003646645 0.3100303898066223 0.2222355866483168 0.08610744549237 0.3477235736204088 0.0359869143678365 +Pcna dependent long patch base excision repair 6 17 2.321015825625623 0.0202859897442202 6.305825242718447 18.131067961165048 -0.2629874999917882 0.517441963572211 3.5188349032394246 1.8997459782268384 0.968142963238218 0.3133577308525272 0.1114073342812727 0.2070995190727305 0.0191106391622076 0.0008083265510004 +Epha mediated growth cone collapse 3 7 2.29115753494881 0.0219543040048026 3.2524271844660193 7.905339805825243 -0.0134632275998438 0.547687937966358 2.2239580154325385 1.9739248348060368 0.9359809307366288 0.3136862668708668 0.1070183553885475 0.1993869387044997 0.1046379555654025 0.0233101974365333 +Cargo trafficking to the periciliary membrane 6 20 2.257480470629305 0.0239780684474264 4.793689320388349 19.611650485436893 0.4417439518734258 0.5335628156487865 3.7330404824062655 2.13833711687666 0.905912611492572 0.3248932005652495 0.1908924307699622 0.0640285846884502 0.0192821424832371 0.0042906431799932 +Biological oxidations 8 44 2.243996586449424 0.0248326209755134 9.58980582524272 42.907766990291265 0.5797258374932459 0.4965502516733612 4.863095917627343 3.5143586004975274 1.0031637620757048 0.3373734498260092 0.0774829110890059 0.061711249787699 0.0073795233338045 0.0056886962616095 +Fatty acid metabolism 11 54 2.241500849954384 0.0249936505337649 12.601941747572816 56.89320388349515 -0.6410370109047604 0.354277511640737 6.622394788478767 4.797678689021568 1.3258270224785833 0.3264233172937892 0.0195209796293355 0.1026543028729206 2.325631566708945e-05 0.000160196255065 +Class a 1 rhodopsin like receptors 4 7 2.2229148575359226 0.0262215417265434 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0981765691424607 0.0010099703116007 0.0132372029803992 0.0028145739091465 +Peptide ligand binding receptors 4 7 2.2229148575359226 0.0262215417265434 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.0802348466038066 0.0005309775927247 0.0072626368836444 0.0010053263520343 +Bile acid and bile salt metabolism 0 5 2.1969577758940804 0.028023461937668 2.424757281553398 6.216019417475728 0.186626892267787 0.5806126455525314 1.7958065200885671 1.3668884939755577 0.8497767995987026 0.308150526237464 0.1026081339138497 0.191600110602388 0.4147125777305785 0.6658017842410733 +Synthesis of bile acids and bile salts 0 5 2.1969577758940804 0.028023461937668 2.424757281553398 6.216019417475728 0.186626892267787 0.5806126455525314 1.7958065200885671 1.3668884939755577 0.8497767995987026 0.308150526237464 0.0937235599037543 0.1758008751515455 0.3854765258786279 0.6307503726508297 +Sema4d induced cell migration and growth cone collapse 3 6 2.18841045618164 0.0286397173148822 2.849514563106796 6.131067961165049 0.0137836048830172 0.4937642018007891 1.7042706942567776 1.0461700029120171 1.0124337106022097 0.3060261841703338 0.0847528009868792 0.1596960736798767 0.0683566835720805 0.0097510399506001 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 6 20 2.184591423991606 0.0289188172981456 7.691747572815534 21.0995145631068 -0.3466659118659361 0.4922744727209283 4.105363512205524 2.424050160748896 1.0608179313016342 0.3301803369974565 0.1287528218161406 0.2372212797486779 0.0042306660622233 0.0002958707603858 +Heparan sulfate heparin hs gag metabolism 2 5 2.16693393990448 0.0302398915742461 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 1.0 1.0 0.1789098805923502 0.2015708610705285 +Gpcr ligand binding 4 10 2.162383910484309 0.0305885967070553 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 0.2027885470531376 0.0096938597365547 0.0980165262967078 0.0707827064406983 +Hdr through homologous recombination hrr 5 20 2.1570235067618584 0.0310038329226485 6.589805825242719 24.111650485436893 -0.0092264701981264 0.5458067298737065 4.0672971108020715 4.028076246394997 0.9713175634602784 0.3148065661700105 0.2778293030066073 0.4724360815693985 0.211317067908577 0.1000607998149871 +Heme signaling 1 5 2.152124133243623 0.0313875788705781 1.230582524271845 5.803398058252427 0.6243516489333526 0.4389875136545328 1.4355867683297088 1.6714879444213002 0.8385522152075133 0.2749710688420202 1.0 1.0 0.5840260458969068 0.5274882304980407 +Cilium assembly 18 60 2.140985926841769 0.0322751729695087 17.691747572815533 60.07281553398058 0.7163847705434252 0.5030560453085753 8.208427462797529 7.176657065505861 1.1196611241046792 0.3669144822823486 0.5965750836212735 0.2574752425413383 0.0740914993991102 0.0076758096099639 +Activation of gene expression by srebf srebp 5 15 2.1241588841935344 0.0336568600090663 4.5 17.614077669902912 -0.4104789735438113 0.3678488977621815 1.9933140672944107 2.3210927861941943 1.1966557776449334 0.274390460759911 1.0 0.0614247268920475 0.2676442975527425 0.051296284939533 +G alpha i signalling events 8 24 2.1191547141048166 0.0340773940273 5.524271844660194 23.135922330097088 0.3542805343277662 0.5682536708808468 3.0075783252329704 3.1998135373141725 0.8730739370642754 0.3221042917790208 0.0691107257825923 0.0101118666995626 0.1612916963216715 0.0265567637490863 +Sema4d in semaphorin signaling 3 8 2.1125532711878487 0.0346390218702339 3.5266990291262137 7.995145631067961 -0.2235317860800916 0.5248607620796493 2.091769766029887 1.2675853232059473 0.9428528394172464 0.3079301576932962 0.1070183553885475 0.1993869387044997 0.1046379555654025 0.0233101974365333 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 7 21 2.111786593658869 0.0347047576980823 7.359223300970874 20.859223300970875 -0.2672141946628648 0.5561702710937696 4.38909586401741 2.011999772877474 0.8912159134669635 0.3145503701499852 0.1828652209005429 0.327507803675052 0.2586784161501983 0.0469837238449897 +Egr2 and sox10 mediated initiation of schwann cell myelination 1 6 2.0852880678154864 0.0370431598785048 1.5631067961165048 6.456310679611651 0.9405466898133904 0.3504222949879002 1.1919625891097876 1.444955732376159 0.8981851290078471 0.2877478182828594 0.0937235599037543 0.0155240337321844 0.082298412398385 0.2531867173469597 +Striated muscle contraction 3 5 2.080454075841524 0.0374839037197021 2.3932038834951457 5.325242718446602 0.6053303821705729 0.3904114603068206 1.4382947114128322 1.0455841909244117 1.143829865381849 0.3284891204761319 1.0 0.1432798584585485 0.0004714775801565 0.0062633876942655 +Dag and ip3 signaling 3 8 2.0700891059635147 0.038444000872492 2.716019417475728 7.949029126213592 0.1042041257629114 0.6264378722427083 2.13715073899254 1.4020872198145156 0.7343129120625027 0.2878262373440899 0.1373006943976843 0.0334071197556988 0.1617118829485157 0.0553856285019619 +Purine salvage 1 5 2.065445810748372 0.0388808378288667 2.111650485436894 5.288834951456311 0.197178541669856 0.4175562109566574 1.6944112000139675 0.9303781473308704 1.1388664400876831 0.3024861591528771 0.0573151884822011 0.1094892401774078 0.0323840811666381 0.1125747569923622 +Constitutive signaling by akt1 e17k in cancer 2 5 2.0438874550735107 0.0409646667358551 1.9296116504854368 5.266990291262136 0.3564799056299969 0.5059420021573545 1.4934799541528836 1.8841643791539875 1.007824838624244 0.3184496724089312 1.0 1.0 0.4559893986318888 0.1188827437046941 +Fatty acyl coa biosynthesis 8 13 1.9931691728471472 0.0462429255029837 3.8640776699029127 15.514563106796116 -0.1829808486879168 0.4222853765507983 2.5949859931504444 1.4820222190196806 1.0812172032678584 0.2668945966653873 1.0 1.0 0.0316151554384263 0.0119362160344991 +Tysnd1 cleaves peroxisomal proteins 1 5 1.9897524220358191 0.046618214864631 1.6504854368932038 5.099514563106796 0.1445135139155807 0.5257016903306084 1.2184562719610088 0.6052358581269563 0.9030664508920184 0.2862787025071504 1.0 1.0 0.0111508905617615 0.0419919493306108 +Traf6 mediated nf kb activation 3 6 1.960728207391865 0.0499107367609781 1.800970873786408 5.669902912621359 0.1650864411930541 0.5327423914035455 1.5102237438317596 1.6436896071200986 0.9190666419337 0.3058592578453835 1.0 0.191600110602388 0.0970188007029606 0.0200033311952484 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..82544944a3778109837d96203c50005ad529b8b2 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 1372, + "title": "Average number of proteins per term", + "value": 18.965014577259474 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..53ffe1c57fedef3aeebe6bbeab534680dad2e1c4 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..70ef6d70c2b3c6f57ca32e2cfc25d4171ad82a37 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,513 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metabolism of lipids 0.4411880143248933 4.040991991297019 5.322557630038638e-05 0.0704246724469476 0.0010003491874538 169 P30536,Q9BZF3,Q6P1A2,Q9HCL2,Q14849,Q9BWD1,Q86X55,Q15125,Q8NCC3,O43681,P35790,Q14914,O15269,Q9NPH0,Q99538,Q9NZJ7,O75131,Q15392,Q15165,O43772,P62826,P07602,Q15800,Q99943,Q8N8N7,Q15185,P48449,O95864,Q96T51,Q16850,P50897,P40939,P10619,Q96N66,Q99570,Q9NZ01,Q9UKG9,Q9Y6X9,O14735,Q8IVS2,P49327,Q8IV08,Q01968,O95487,Q06136,Q15067,Q9UMR5,P16278,O00116,Q6UWP7,Q14739,Q9UBM7,O15254,Q10713 54 +Ikba variant leads to eda id 0.887160820648579 3.737747647862917 0.0001856761687435 0.2249063023420871 0.0026536219116264 2 Q9Y6K9 1 +Phase 0 rapid depolarisation 0.8825281270681699 3.715774770667619 0.0002025819808015 0.2426809397831041 0.0027846403624932 2 Q13555 1 +Dex h box helicases activate type i ifn and inflammatory cytokines production 0.8371939113170108 3.4974647227161872 0.0004697028292108 0.4751189822426259 0.004957019774468 2 Q9H2U1 1 +Creatine metabolism 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.5296384457777789 0.0055444583026619 2 P12532 1 +Heme degradation 0.9087127016716274 3.4326885017066986 0.0005976282834758 0.5596525101291641 0.0059850073352474 3 P30519 1 +The activation of arylsulfatases 0.8173395102581111 3.3999138725344857 0.0006740708182622 0.6035229026526404 0.0066534184363722 2 O43681 1 +Aflatoxin activation and detoxification 0.8084050297816052 3.3556172630242704 0.0007918807715239 0.6627365216781556 0.0073409487738569 2 O14880 1 +Protein localization 0.4990009346645242 3.325884186603625 0.0008813854199443 0.7017412921414591 0.0081158442695543 75 Q99595,Q9NR77,P09601,O43681,O60220,Q9NS69,Q9Y584,P21796,O60830,Q5JRX3,P05067,Q9Y5J9,Q9UKG9,P50542,P46379,Q15067,O00116,Q9Y5L4,O15254,Q10713 20 +Metabolism of steroids 0.6112806252749418 3.3174573432122414 0.0009084078572063 0.7126062389057123 0.0082434417998215 42 P30536,P48449,P49327,Q9BZF3,O95487,Q9HCL2,Q14849,Q86X55,Q9BWD1,Q15125,P62826,Q15392,Q16850,Q99538,Q15800,Q14739 16 +Bmal1 clock npas2 activates circadian gene expression 0.8816499382821739 3.310081075170166 0.0009326895138161 0.7220314058481039 0.0083094156685443 3 P43490 1 +Diseases of immune system 0.878517047335321 3.2957637552959724 0.000981545177098 0.7400695878575463 0.0085804556661728 3 Q9Y6K9,O15111 2 +Camk iv mediated phosphorylation of creb 0.8765092956764085 3.2865746442039243 0.001014138921251 0.7514483512687149 0.0086962412497274 3 Q13555 1 +Aryl hydrocarbon receptor signalling 0.8355377398376063 3.096679052143239 0.0019570163311213 0.9319598399664774 0.0148461495421456 3 Q15185 1 +Synthesis of pips at the late endosome membrane 0.755459960291201 3.087854074564032 0.0020160744203656 0.9372656505650953 0.0148461495421456 2 Q99570 1 +Acyl chain remodelling of pc 0.7491727332892187 3.0554411634448604 0.0022472969104359 0.9543504302070502 0.0148461495421456 2 Q6P1A2 1 +Mitochondrial protein import 0.5978554178862053 3.012024785484771 0.0025951140755826 0.9717065363504144 0.0160382725752225 36 Q99595,O60830,Q9Y584,Q5JRX3,O60220,Q9Y5J9,Q9Y5L4,Q9NS69,Q10713,P21796 10 +Hs gag degradation 0.8019634452300971 2.9375927408814633 0.0033077122347207 0.989387293577042 0.0194771724722609 3 P16278 1 +Cholesterol biosynthesis 0.7726799115496281 2.92768227110905 0.0034149882837763 0.990844334558523 0.0197808267479208 15 P48449,Q16850,Q9BWD1,Q15392,Q15800,Q14739 6 +Vegfr2 mediated cell proliferation 0.799136351616832 2.9240501233865253 0.0034550910659447 0.9913361240335068 0.0197808267479208 3 O43865 1 +Linoleic acid la metabolism 0.707809397749839 2.838804068687347 0.0045282952453105 0.998024493446961 0.0247168196575613 2 O95864 1 +Beta oxidation of butanoyl coa to acetyl coa 0.7720750984956585 2.7932398623068173 0.0052182981894337 0.9992369985097664 0.0276428768953788 3 P40939 1 +Ecm proteoglycans 0.7710780730261418 2.788379222621347 0.005297249529149 0.9993157206727684 0.0278316142285047 3 P05067 1 +Inflammasomes 0.844634332928514 2.7848436239208127 0.0053553543413449 0.9993684232189508 0.0278316142285047 4 P05067 1 +The nlrp3 inflammasome 0.844634332928514 2.7848436239208127 0.0053553543413449 0.9993684232189508 0.0278316142285047 4 P05067 1 +Purinergic signaling in leishmaniasis infection 0.844634332928514 2.7848436239208127 0.0053553543413449 0.9993684232189508 0.0278316142285047 4 P05067 1 +Ras processing 0.8419926775195108 2.7729919139761985 0.0055543500862953 0.999520041379634 0.0285414543760195 4 O60725 1 +G2 m dna replication checkpoint 0.6939113170086085 2.764661326253227 0.0056981922747878 0.9996064406925838 0.0291713425410781 2 P06493 1 +Endosomal vacuolar pathway 0.8388645407325637 2.758935104547266 0.005799004962196 0.99965755294827 0.0295571289964135 4 Q9UIQ6,P10321 2 +Acyl chain remodeling of cl 0.7639558244789106 2.7535713009181255 0.0058948928171851 0.9996999991891736 0.0297345328866838 3 P40939 1 +Transport of bile salts and organic acids metal ions and amine compounds 0.7545463518036841 2.7073529155260996 0.0067822116542397 0.9999118871953095 0.0334719222648091 3 Q15043 1 +Ptk6 regulates cell cycle 0.6786896095301178 2.6826582928525524 0.0073039577000875 0.9999571500352638 0.0355355672500711 2 P11802 1 +Mucopolysaccharidoses 0.8199244523242277 2.673300139022468 0.0075109016816385 0.9999678099044808 0.036157744235818 4 P15586,P16278 2 +Role of phospholipids in phagocytosis 0.8190347619300725 2.6692552742218423 0.0076019648972387 0.9999716176123024 0.0364681672692711 4 Q8IV08,O43865 2 +Traf6 mediated irf7 activation 0.6631369953673123 2.5979987360988677 0.0093768839101191 0.9999975655304224 0.0433996417703526 2 Q7Z434 1 +Traf3 dependent irf activation pathway 0.6631369953673123 2.5979987360988677 0.0093768839101191 0.9999975655304224 0.0433996417703526 2 Q7Z434 1 +Signaling by activin 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999977270582552 0.0433996417703526 2 P28482 1 +Activation of the ap 1 family of transcription factors 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999977270582552 0.0433996417703526 2 P28482 1 +Signaling by nodal 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999977270582552 0.0433996417703526 2 P28482 1 +Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 0.6621442753143671 2.5925647054581904 0.0095263259355145 0.9999980207102956 0.0437127731890498 2 Q32MZ4 1 +Pregnenolone biosynthesis 0.7966896423348862 2.5670054528250796 0.0102580999289561 0.9999992820008328 0.0467578508389626 4 P30536 1 +Phase i functionalization of compounds 0.7053231573679599 2.557141465310796 0.0105536288723484 0.9999995233706674 0.047787388821327 15 O43169,O00170,Q96DG6,Q16850,P07099,P30837,Q15185 7 +Dcc mediated attractive signaling 0.6499007279947118 2.5252448629998714 0.0115617699586261 0.999999882304153 0.0510228337652624 2 P60953 1 +Formyl peptide receptors bind formyl peptides and many other ligands 0.7179654617764972 2.525126299969753 0.0115656715021841 0.999999882939817 0.0510228337652624 3 P05067 1 +Proton coupled monocarboxylate transport 0.6432825943084115 2.488623726892297 0.0128238607437869 0.999999979608026 0.0549823029389865 2 P53985 1 +Small interfering rna sirna biogenesis 0.7673474943367687 2.4307915468461276 0.0150658795942248 0.9999999990991456 0.0624482984993249 4 O75569 1 +Akt phosphorylates targets in the cytosol 0.7653630873787451 2.4214991086136783 0.015456638947854 0.9999999994773494 0.0636832091184859 4 P49815,P31751 2 +Interferon gamma signaling 0.7420600881739495 2.414825200446549 0.0157427627066593 0.99999999964923 0.0644748371150345 11 P04439,Q13557,P10321,Q13555,P19474 5 +Vitamin d calciferol metabolism 0.6951340615690169 2.4093134385296007 0.0159825650856544 0.9999999997489082 0.0652621407664222 3 Q99538,P38435 2 +Beta oxidation of pristanoyl coa 0.7567762472097763 2.3811716621954684 0.0172576677441731 0.9999999999576143 0.0694355429472303 4 O15254 1 +Wax and plasmalogen biosynthesis 0.752542028625491 2.361215603783167 0.0182151371634389 0.9999999999888722 0.0730735911936789 4 Q8WVX9,O00116 2 +G beta gamma signalling through pi3kgamma 0.7447884776519237 2.324552268060219 0.0200959136263194 0.9999999999991986 0.0796866864026309 4 P61586 1 +Pcna dependent long patch base excision repair 0.643094280097816 2.321015825625623 0.0202859897442202 0.9999999999993858 0.0802085819281561 17 P27695,P28340,Q9NR33,P41440,Q9NRF9,P35250 6 +Interaction between l1 and ankyrins 0.6762661370407134 2.3123886475843225 0.0207562754056898 0.999999999999682 0.0815977359788149 3 Q01082,O15020 2 +Epha mediated growth cone collapse 0.8339879061375346 2.29115753494881 0.0219543040048026 0.9999999999999408 0.0850884324705912 7 P35580,P61586,P60660 3 +Pd 1 signaling 0.6052283256121849 2.274870668397745 0.0229136893712607 0.9999999999999846 0.0878144743501946 2 Q06124 1 +Regulation of tnfr1 signaling 0.7315436906573894 2.261562825117123 0.0237244270011585 0.9999999999999952 0.0901659663312727 4 Q9Y6K9,O15111 2 +Cargo trafficking to the periciliary membrane 0.5991160168918852 2.257480470629305 0.0239780684474264 0.9999999999999966 0.090878204170909 20 A6NIH7,O43924,Q8IYI6,Q96KP1,Q9NV70,Q10713 6 +Biological oxidations 0.4803587276345843 2.243996586449424 0.0248326209755134 0.999999999999999 0.093445326757448 44 O14880,O43169,Q8TB61,Q9NUJ1,Q16850,P07099,P30837,Q15185 8 +Fatty acid metabolism 0.436616170269288 2.241500849954384 0.0249936505337649 0.9999999999999992 0.093584250629434 54 Q15165,O43772,P50897,O15254,P40939,Q9UMR5,Q14914,Q8N8N7,Q15185,Q9UKG9,Q9Y6X9 11 +Mapk1 erk2 activation 0.6617014233697408 2.2368158543221837 0.0252983779066842 0.9999999999999994 0.0943189524129639 3 Q06124,P28482 2 +Class a 1 rhodopsin like receptors 0.8182082582016506 2.2229148575359226 0.0262215417265434 1.0 0.0969702297811795 7 P07602,Q9NRV9,P05067,P42892 4 +Peptide ligand binding receptors 0.8182082582016506 2.2229148575359226 0.0262215417265434 1.0 0.0969702297811795 7 P07602,Q9NRV9,P05067,P42892 4 +Sialic acid metabolism 0.7222368838266575 2.2170302750176356 0.0266210227626215 1.0 0.097919686944549 4 P10619 1 +Sema4d induced cell migration and growth cone collapse 0.8358647174192911 2.1884104561816393 0.0286397173148822 1.0 0.1036772880106027 6 P35580,P61586,P60660 3 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.5880102489235604 2.184591423991606 0.0289188172981456 1.0 0.1044121508764625 20 P27695,P09874,Q9NR33,P41440,Q9NRF9,P35250 6 +Chl1 interactions 0.586697551290544 2.1688180637984726 0.0300964992744992 1.0 0.1075322838661794 2 P11142 1 +Met interacts with tns proteins 0.586697551290544 2.1688180637984726 0.0300964992744992 1.0 0.1075322838661794 2 Q9NWH9 1 +Heparan sulfate heparin hs gag metabolism 0.7706200920506074 2.16693393990448 0.0302398915742461 1.0 0.1077639772464043 5 Q7LGA3,P16278 2 +Gpcr ligand binding 0.722457872059731 2.162383910484309 0.0305885967070553 1.0 0.1087242349276683 10 P07602,Q9NRV9,P05067,P42892 4 +Hdr through homologous recombination hrr 0.5838307947984683 2.1570235067618584 0.0310038329226485 1.0 0.1099153973381751 20 Q9NR33,Q9UQ84,P41440,Q9NRF9,P35250 5 +Heme signaling 0.7673259080490941 2.152124133243623 0.0313875788705781 1.0 0.110989067552663 5 P09601 1 +Cilium assembly 0.4191524908995136 2.1409859268417692 0.0322751729695087 1.0 0.1132520135912174 60 O94927,A6NIH7,O43805,P68371,P63167,O43924,P43034,Q8IYI6,O95684,Q9BUF5,P49368,Q96KP1,A0AVF1,Q96CS2,Q9H6D7,Q92973,Q9NV70,Q10713 18 +Activation of gene expression by srebf srebp 0.6300521359111975 2.1241588841935344 0.0336568600090663 1.0 0.1172010455138045 15 P48449,P49327,Q9HCL2,Q16850,Q86X55 5 +G alpha i signalling events 0.5440231123963234 2.1191547141048166 0.0340773940273 1.0 0.1180661227410496 24 Q13557,O43865,Q13555,P07602,Q9NZJ7,Q9NRV9,P05067,Q00535 8 +Sema4d in semaphorin signaling 0.7671291993833819 2.1125532711878487 0.0346390218702339 1.0 0.1196354963863542 8 P35580,P61586,P60660 3 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.5655979029496009 2.111786593658869 0.0347047576980823 1.0 0.1196354963863542 21 P28340,Q9NR33,P55072,Q07864,P41440,Q9NRF9,P35250 7 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.8113940406416031 2.0852880678154864 0.0370431598785048 1.0 0.1264259088390761 6 Q9NR77 1 +Striated muscle contraction 0.7514581530002578 2.0804540758415233 0.0374839037197021 1.0 0.1276126945494573 5 P09493,P08670,P67936 3 +Dag and ip3 signaling 0.7578721210982026 2.0700891059635147 0.038444000872492 1.0 0.1302349856717506 8 Q13557,O43865,Q13555 3 +Purine salvage 0.748150581892601 2.065445810748372 0.0388808378288667 1.0 0.1313904174906531 5 P00813 1 +Irak1 recruits ikk complex 0.6288848005811284 2.0641508376677535 0.0390034171086188 1.0 0.1314808065676292 3 Q9Y6K9 1 +Constitutive signaling by akt1 e17k in cancer 0.7434085438715285 2.0438874550735107 0.0409646667358551 1.0 0.1367191115182505 5 P49815,P31751 2 +Fatty acyl coa biosynthesis 0.6246274828887746 1.9931691728471472 0.0462429255029837 1.0 0.1514207489023714 13 P49327,Q13085,P50897,Q9UMR5,P33121,Q53GQ0,Q9NZ01,Q9Y6X9 8 +Tysnd1 cleaves peroxisomal proteins 0.7315471166248457 1.9897524220358191 0.046618214864631 1.0 0.1522861685577946 5 O00116 1 +Traf6 mediated nf kb activation 0.7821848135409838 1.960728207391865 0.0499107367609781 1.0 0.1622690304172085 6 Q9Y6K9,P05067,O15111 3 +Glycerophospholipid biosynthesis 0.5083509394700384 1.952237628785579 0.0509099986200354 1.0 0.1640786470399337 26 Q8IV08,Q6P1A2,Q9HCL2,Q8NCC3,P40939,P35790,Q6UWP7,Q9NPH0,Q96N66,O75131,O14735 11 +Termination of translesion dna synthesis 0.5716151179672908 1.9401994989646552 0.0523554493956548 1.0 0.1678310200253234 18 P28340,Q9NR33,P41440,Q9NRF9,P35250 5 +Muscle contraction 0.5064237841993419 1.9375391723614597 0.0526794697993004 1.0 0.168476066584243 26 O43865,P08670,Q13555,P06753,P09493,P67936 6 +Chrebp activates metabolic gene expression 0.7194094750067503 1.9340501936589891 0.053106956787261 1.0 0.1694482435165632 5 O00763,P49327,Q99943 3 +Signaling by vegf 0.5106724424298803 1.9315464270085008 0.0534155136803833 1.0 0.1699992077073758 25 Q9UQB8,Q05655,O43865,Q8WUW1,P61586,Q7L576,P31751 7 +Estrogen dependent nuclear events downstream of esr membrane signaling 0.6632450331125743 1.9296408512374792 0.053651353452838 1.0 0.1699992077073758 4 O14980,P31751,P28482 3 +Negative regulation of nmda receptor mediated neuronal transmission 0.7167553410803092 1.9218291463011243 0.0546272595909818 1.0 0.171115525476774 5 Q13555 1 +Long term potentiation 0.7167553410803092 1.9218291463011243 0.0546272595909818 1.0 0.171115525476774 5 Q13555 1 +Ras activation upon ca2 influx through nmda receptor 0.7167553410803092 1.9218291463011243 0.0546272595909818 1.0 0.171115525476774 5 Q13555 1 +Unblocking of nmda receptors glutamate binding and activation 0.7167553410803092 1.9218291463011243 0.0546272595909818 1.0 0.171115525476774 5 Q13555 1 +Gpvi mediated activation cascade 0.7148182891279614 1.912900821387283 0.0557607504125381 1.0 0.1738721581045507 5 P60953,P61586,P84095 3 +Resolution of abasic sites ap sites 0.5291417030877382 1.9068188680737292 0.056544047155842 1.0 0.1755168160584056 22 P27695,P09874,Q9NR33,P41440,Q9NRF9,P35250 6 +Rho gtpases activate rocks 0.6710827957708019 1.9031583008772537 0.0570198924303269 1.0 0.1765943395359108 10 P35580,P61586,P60660 3 +Assembly and cell surface presentation of nmda receptors 0.6706398621243828 1.9008950281207084 0.0573157634624057 1.0 0.1771108726811276 10 Q13555,Q13557,P68371 3 +Ddx58 ifih1 mediated induction of interferon alpha beta 0.5830209506917355 1.8954769311989716 0.0580292451250352 1.0 0.1789126389023559 16 Q9Y6K9,Q13526,Q15366,O15111,P05067 5 +Activation of the pre replicative complex 0.5338229941878121 1.8931432260381416 0.0583388250751679 1.0 0.1793689288825112 21 Q9NRF9,Q9Y619,Q14566,P09884 4 +Dual incision in gg ner 0.5337149378324191 1.892392453243936 0.0584387107948123 1.0 0.1793689288825112 21 P09874,Q9NR33,P41440,Q9NRF9,P35250 5 +Zbp1 dai mediated induction of type i ifns 0.7036363166064625 1.86121214612458 0.0627142237967084 1.0 0.19163455467502 5 Q9Y6K9,O15111 2 +Rip mediated nfkb activation via zbp1 0.7036363166064625 1.86121214612458 0.0627142237967084 1.0 0.19163455467502 5 Q9Y6K9,O15111 2 +Signaling by gpcr 0.4474940291066567 1.8504388909859768 0.0642503180196125 1.0 0.195571758443323 41 O43865,Q13555,P61586,P42892,P07602,P31751,Q9NZJ7,Q9NRV9,P05067,Q00535 10 +Met activates ptk2 signaling 0.5868917576961266 1.8385325542692783 0.0659839693864388 1.0 0.1998773967981024 3 Q9NWH9,P11047 2 +The phototransduction cascade 0.6400414826479182 1.814276642246818 0.0696351457562038 1.0 0.2086013536626893 4 P50579 1 +Insulin processing 0.6530078139358507 1.810427854969092 0.0702294629099873 1.0 0.2099233619008771 10 Q9Y4I1,Q96KP1,Q8IYI6 3 +Carboxyterminal post translational modifications of tubulin 0.7389984279161976 1.7737771269751814 0.0761000229778647 1.0 0.2232218730792985 6 Q14166,P68371 2 +Metabolism of porphyrins 0.6685337029607694 1.7635691534523077 0.077804544913659 1.0 0.2267695157689351 9 P22830,P30519 2 +Vitamin b5 pantothenate metabolism 0.6298672353447503 1.7633070399254147 0.0778487186058078 1.0 0.2267695157689351 4 Q13057 1 +Dna replication initiation 0.7355062165520594 1.7585227589713937 0.078658602608741 1.0 0.2276784868759339 6 Q9NRF9,P09884 2 +Transport of the slbp dependant mature mrna 0.4531987229962444 1.744814895991508 0.081017095026175 1.0 0.2325427915814062 32 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1,Q09161 8 +Irs mediated signalling 0.6245546048325517 1.7366035790755066 0.0824571673544452 1.0 0.2349972974916973 4 Q99570,P31751 2 +Antigen processing cross presentation 0.4022990109263321 1.7292949197358594 0.0837563254179591 1.0 0.2349972974916973 51 P60900,P20618,P04439,Q9Y6K9,P10321,Q9UIQ6,P61289,P49721,O75832,O15111,P28074 11 +Metabolism of steroid hormones 0.7255302293794914 1.7148407729456774 0.0863744238681216 1.0 0.2408652633070384 6 P30536 1 +Diseases of mismatch repair mmr 0.5637206223104889 1.7119512655775602 0.0869056499341662 1.0 0.2417851351777153 3 P20585,P52701 2 +Rho gtpases activate cit 0.6087214720949018 1.7111320062913635 0.0870567469225884 1.0 0.2417851351777153 11 P35579,P35580,P61586,P60660 4 +Ion transport by p type atpases 0.6575679843557671 1.7092893981836843 0.0873973561615555 1.0 0.242240752835665 9 Q13557,Q9HD20,Q13555,P05023 4 +Semaphorin interactions 0.5347070557913379 1.7012117061663696 0.0889032404636176 1.0 0.2459178345082326 18 P35580,P61586,Q00535,P60660 4 +Polymerase switching 0.580462173971265 1.698397120813884 0.0894328351542617 1.0 0.2467171260743846 12 P35250,P09884,P41440 3 +Transport of small molecules 0.3187454525219096 1.697766488613755 0.0895518431377868 1.0 0.2467171260743846 145 P60900,Q8TB61,Q8WTV0,Q99797,P09601,Q15043,P21796,Q70HW3,Q93050,Q13555,P61289,P49721,Q9HD20,O75832,P30519,P28074,O15118,P20618,P61916,Q9UBX3,P45880,P08183,Q10713 23 +Response to elevated platelet cytosolic ca2 0.4447206177787574 1.695172824902792 0.0900426404521994 1.0 0.2475721497002357 34 P07737,O94919,Q8NBX0,Q06481,P07602,O43852,Q9NZJ7,P05067 8 +Nucleotide salvage 0.7184861869040498 1.6839053235678658 0.092199967354118 1.0 0.2524917269657684 6 P00813,P55263 2 +Telomere c strand synthesis initiation 0.6137534022056756 1.6821316224178773 0.0925433196373537 1.0 0.2529271604431261 4 P09884 1 +Recruitment of numa to mitotic centrosomes 0.4417656475569328 1.6693519479151313 0.095047650718681 1.0 0.2587408269564095 34 O94927,Q15154,O43805,P68371,P63167,P43034,O95684,Q9BUF5,Q96CW5,Q96CS2,Q9H6D7 11 +Export of viral ribonucleoproteins from nucleus 0.4575346426796963 1.6623436700554814 0.0964438864057881 1.0 0.2619569688347022 30 P55735,Q92621,Q8NFH4,P62826,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 8 +Ion channel transport 0.4812513324291479 1.656196311429275 0.0976820699905423 1.0 0.2638185039902048 24 Q13555,Q93050 2 +Gap filling dna repair synthesis and ligation in gg ner 0.5349755579526896 1.6474909407590088 0.0994571767666525 1.0 0.2678787410457625 17 P28340,Q9NR33,P41440,Q9NRF9,P35250 5 +Postmitotic nuclear pore complex npc reformation 0.479888674997846 1.645964035210942 0.0997711637568401 1.0 0.2678787410457625 24 P55735,Q92621,Q8NFH4,P62826,Q8NFH3,Q5SRE5,Q9BTX1,Q92973 8 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7087206869990876 1.640898007853996 0.1008185886367929 1.0 0.2691064138035052 6 Q5KU26,P10321 2 +Ca dependent events 0.6876437841882203 1.639433328044467 0.1011230453824849 1.0 0.2691064138035052 7 Q13557,Q13555 2 +Nuclear envelope ne reassembly 0.4033646529093573 1.6262857103466062 0.103888890183257 1.0 0.2748399608079662 48 P55735,Q86XL3,P68371,O75531,Q92621,Q8NFH4,P62826,Q9BUF5,Q5SRE5,Q9BTX1,Q14739,Q92973 12 +Phospholipid metabolism 0.425207242135145 1.620297363897191 0.1051684149146285 1.0 0.2774828178132123 40 Q01968,Q8IV08,Q6P1A2,Q9HCL2,Q96T51,Q8NCC3,P40939,P35790,Q99943,Q9NPH0,Q96N66,Q6UWP7,Q99570,O75131,Q10713,O14735 16 +Ion homeostasis 0.6391319475655453 1.6175307765210705 0.1057637578648311 1.0 0.2775680799292592 9 Q13557,O43865,Q13555 3 +Aurka activation by tpx2 0.4452601904994563 1.617327263312121 0.1058076572908182 1.0 0.2775680799292592 31 O94927,Q15154,O43805,P68371,P63167,P07437,P43034,O95684,O14965,Q96CS2,Q9ULW0,Q9H6D7,P61163 13 +Cardiac conduction 0.6149184620896105 1.6126982809493446 0.1068100742149238 1.0 0.2785996612602195 10 Q13557,O43865,Q13555 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.5881485591872807 1.598529521890466 0.1099251806526924 1.0 0.286180925722 11 P46379,P09601,P05067 3 +Regulation of cholesterol biosynthesis by srebp srebf 0.4844095624165054 1.5864406253844496 0.1126393909177769 1.0 0.2915872534701698 22 P48449,P49327,O95487,Q9HCL2,Q16850,Q86X55,P62826 7 +Branched chain amino acid catabolism 0.5406325854969939 1.5851706485535948 0.1129275673561793 1.0 0.2917347987167529 15 P09622,P11182 2 +Polymerase switching on the c strand of the telomere 0.5476055708194726 1.5843167470030235 0.1131216566452715 1.0 0.2917347987167529 14 P35250,P09884,P28340,P41440 4 +Degradation of cysteine and homocysteine 0.5939691170156494 1.581770636233297 0.1137019406661732 1.0 0.2921330760187072 4 Q9UBX3,P32929 2 +Dna replication pre initiation 0.3695131985942604 1.5798933176824383 0.1141312998095491 1.0 0.2926881183900962 62 P60900,P20618,Q9Y619,Q14566,P61289,P49721,O75832,P09884,Q9NRF9,P28074 10 +Diseases associated with glycosylation precursor biosynthesis 0.6744324393092267 1.5787381122248778 0.1143961390915966 1.0 0.292819967973266 7 P10619 1 +Synthesis of dna 0.3522047749750061 1.577537818430372 0.1146718273289861 1.0 0.2929790448703334 76 P60900,Q9NRF9,P35250,P28072,P49720,P61289,Q9UL46,P49721,Q9BRT9,O75832,P25788,P41440,P28074,P20618,P63208,P33991,Q14566,Q9NR33,P09884,O43242,P28340,P30260,O43913,P49736,Q07864,Q9Y619 26 +Dna damage bypass 0.4635398359380226 1.5726466080995432 0.1158006691474571 1.0 0.2953132306139612 25 P28340,Q9NR33,P55072,Q07864,P41440,Q9NRF9,P35250 7 +Sumoylation of ubiquitinylation proteins 0.453328054188793 1.5673635734145237 0.117029733316982 1.0 0.2967925953990747 28 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 7 +Regulation of glucokinase by glucokinase regulatory protein 0.453328054188793 1.5673635734145237 0.117029733316982 1.0 0.2967925953990747 28 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 7 +Sumoylation of sumoylation proteins 0.453328054188793 1.5673635734145237 0.117029733316982 1.0 0.2967925953990747 28 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 7 +Cell surface interactions at the vascular wall 0.5569890662655936 1.5628599506615743 0.118085539455699 1.0 0.2983671457333683 12 P14174 1 +Dna strand elongation 0.4618331169019818 1.5594903245916023 0.1188803728143141 1.0 0.2997669278587115 25 P28340,Q14566,Q9BRT9,P09884,P41440,P35250 6 +Sting mediated induction of host immune responses 0.6899787705611786 1.557994961653402 0.1192344424806053 1.0 0.2997669278587115 6 P19474 1 +Interferon signaling 0.3653023444008851 1.5375726249625556 0.1241531451081279 1.0 0.3086805905634184 63 P55735,P21333,P04439,P10321,Q05655,Q13555,Q13557,Q92621,Q13526,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,P19474,Q9BTX1 15 +Cellular response to heat stress 0.367126115696485 1.5331396572835383 0.1252414483052368 1.0 0.3101647420122473 59 P55735,Q13557,Q13555,Q92621,Q8NFH4,O95429,P55072,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1,Q99615,Q15185 13 +Recognition of dna damage by pcna containing replication complex 0.4985878774192598 1.518894646615396 0.1287890167526728 1.0 0.3178031132817754 19 P28340,Q9NR33,P41440,Q9NRF9,P35250 5 +Beta oxidation of hexanoyl coa to butanoyl coa 0.579544382588854 1.5081708255608814 0.131510812039461 1.0 0.3216271552908031 4 P40939 1 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.579544382588854 1.5081708255608814 0.131510812039461 1.0 0.3216271552908031 4 P40939 1 +Synaptic adhesion like molecules 0.678382468779183 1.5064835381160409 0.1319430899262472 1.0 0.322110176830625 6 P10586,P41440 2 +Polb dependent long patch base excision repair 0.6236476682892632 1.4848816241492526 0.1375751845954131 1.0 0.3311458829208893 5 P27695 1 +Sumoylation of dna replication proteins 0.418823263153646 1.4794049071901791 0.1390321293939092 1.0 0.3340666926942967 35 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,O14965,Q5SRE5,Q9BTX1 8 +Leishmania infection 0.4138314716835797 1.461935520199248 0.1437588801816383 1.0 0.3434945904283593 37 Q9UQB8,O43865,Q9Y4I1,P09601,P05067 5 +Fcgamma receptor fcgr dependent phagocytosis 0.4268085690962404 1.4612119631334852 0.1439572809739844 1.0 0.3434945904283593 31 Q9UQB8,Q05655,Q8IV08,O43865,Q9Y4I1,Q8WUW1,Q7L576,Q96F07,P35579 9 +G protein beta gamma signalling 0.6674518251987988 1.457796848951615 0.1448965470947703 1.0 0.3451355253715709 6 P60953,P61586,P31751 3 +Glycosaminoglycan metabolism 0.5193980129991049 1.454040860663704 0.1459349780663141 1.0 0.3470065682963311 15 P15586,Q8TB61,Q7LGA3,P08236,P16278,Q9UHD1 6 +Iron uptake and transport 0.4966198105045818 1.450372104163456 0.1469547818214431 1.0 0.3482805884516763 18 P09601,Q93050,P30519 3 +Ns1 mediated effects on host pathways 0.4168527130462238 1.4502871177349184 0.1469784699078138 1.0 0.3482805884516763 34 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 7 +Cytosolic sensors of pathogen associated dna 0.4962902069093129 1.448187126655068 0.1475647238870632 1.0 0.3488542837586195 18 Q9Y6K9,Q9H2U1,P78527,O15111,P19474 5 +Mitotic g1 phase and g1 s transition 0.3420741754081427 1.4430811555657974 0.1489976111203184 1.0 0.3512452275894791 76 P60900,P20618,Q9Y619,Q14566,P04818,P61289,Q9NR33,P49721,O75832,P31751,P09884,Q9NRF9,P28074 13 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.6031741377128161 1.4370290536864718 0.1507097383026061 1.0 0.3546719741872652 9 P09601,Q9Y6K9,P05067 3 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.6124383391606979 1.4313964341252938 0.1523166298025307 1.0 0.3568419008015551 5 Q99570,Q06124,P31751 3 +Platelet activation signaling and aggregation 0.3670351677968629 1.4297298733112884 0.1527945628665292 1.0 0.3571280072451075 53 P07737,O94919,P61586,Q8NBX0,Q06481,P07602,P84095,P13473,O43852,Q9NZJ7,P05067 11 +Keratan sulfate degradation 0.5626304629562013 1.4214894886512686 0.1551745072327066 1.0 0.3608464812258873 4 P16278 1 +Ticam1 rip1 mediated ikk complex recruitment 0.5616007798227836 1.4162012561640098 0.1567165882267993 1.0 0.3632009754244459 4 Q9Y6K9 1 +Mrna decay by 3 to 5 exoribonuclease 0.5056027388118861 1.4112220474012005 0.1581791511990689 1.0 0.3653565579884217 16 Q969T7,Q9Y3B2 2 +Cytokine signaling in immune system 0.2970802537258442 1.4048158813160954 0.1600760353183017 1.0 0.3691165049692604 171 P60900,P10321,P09601,Q5SRE5,Q13126,P55735,Q9Y6K9,O00170,P14174,Q13555,P08670,Q13526,P61289,P49721,O75832,P19474,P28074,P05067,P20618,P04439,P31751,O15111,Q13557,Q8NFH4,Q15369,Q9BTX1 26 +Innate immune system 0.2702801579852278 1.402413442757312 0.1607918214242121 1.0 0.3701449311980185 283 P60900,Q9UQB8,P15586,P10321,P11717,P63167,Q9H2U1,Q8WUW1,P42785,P09601,O43681,O95298,Q99538,P35579,Q9NZJ7,Q92542,O75131,Q93050,Q9Y6K9,P14174,Q9Y4I1,P61586,Q13526,P61289,P07602,Q7L576,P49721,O75832,P84095,P19474,P30519,P28074,P05067,P20618,P04439,Q05655,O43865,Q9Y487,P78527,P08236,O15260,P10619,Q15366,P35573,P13473,O15111,Q99536,P61916,Q8IV08,P68371,P09429,P53634,P16278 53 +Recruitment of mitotic centrosome proteins and complexes 0.419305674712141 1.397445848811535 0.1622795399191532 1.0 0.3718642734730129 31 O94927,Q15154,O43805,P68371,P63167,P43034,O95684,Q96CW5,Q96CS2,Q9H6D7 10 +Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.6041910458053616 1.3919647532701185 0.1639330715608433 1.0 0.3742365626979652 5 Q9Y6K9 1 +Rho gtpases activate nadph oxidases 0.6507620941020744 1.383251161931332 0.1665878672078773 1.0 0.3790357442938767 6 Q05655,Q13526,P28482,Q99570,P27361 5 +Base excision repair 0.4371653735958868 1.3684550408996727 0.1711696856927054 1.0 0.3886308004270466 25 P27695,P09874,P28340,Q9NR33,Q9NYB0,P41440,Q9NRF9,P35250 8 +Interferon alpha beta signaling 0.5892387623939821 1.3666616492735355 0.1717313839065399 1.0 0.3886308004270466 9 Q06124,P04439,P10321 3 +Lagging strand synthesis 0.4984592816515295 1.3658922388212695 0.1719727891187448 1.0 0.3886308004270466 16 P35250,P09884,P41440 3 +Class i mhc mediated antigen processing presentation 0.3160147142555459 1.364200445773779 0.1725044879446584 1.0 0.3886308004270466 109 P60900,P10321,P55786,P55735,Q9Y6K9,Q9C0C9,P61289,P49721,O75832,P19474,P28074,P20618,P04439,Q9NZ08,A0AVT1,O15111,O95487,Q9UIQ6,Q8IWV8,Q15369,P09429 21 +Slc transporter disorders 0.4064387217773291 1.3581729132509142 0.1744088233458183 1.0 0.3917089222175442 34 P55735,Q92621,Q8NFH4,P53985,Q8N1F7,Q8NFH3,Q5SRE5,Q9BTX1 8 +Sulfur amino acid metabolism 0.5867813206923087 1.3542358818942322 0.1756611347685512 1.0 0.3936035253043613 9 Q9UBX3,Q13126 2 +Pink1 prkn mediated mitophagy 0.5864809106546219 1.352716603485716 0.1761461840647797 1.0 0.3936035253043613 9 Q9NS69,P21796 2 +Arachidonic acid metabolism 0.6056813788334835 1.3487088546007555 0.177430500306696 1.0 0.3951861143194594 8 Q8N8N7,Q14914,Q15165 3 +Pcp ce pathway 0.3758466216189468 1.3427656194510793 0.179347879228529 1.0 0.3988092225308619 48 P60900,P07737,P61586,P61289,P49721,O75832,P28074 7 +Rho gtpases activate ktn1 0.6020609147072371 1.3311629097915116 0.1831354126850666 1.0 0.4048763316681946 8 P60953,P61586,P84095 3 +Telomere c strand lagging strand synthesis 0.4782476450786749 1.3283342328611911 0.1840677154691352 1.0 0.4060143177229157 18 P35250,P09884,P28340,P41440 4 +Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.6354527133444617 1.314705048711991 0.1886090491479684 1.0 0.4140345846896202 6 Q9Y6K9,P05067,O15111 3 +Signaling by the b cell receptor bcr 0.3830508473422857 1.3062108060975637 0.191480879008183 1.0 0.4189980318966939 44 P60900,P20618,Q9Y6K9,O43865,P61289,P49721,O75832,P28074 8 +Transport of connexons to the plasma membrane 0.5842503542121078 1.2964184234366225 0.1948313681862918 1.0 0.4211997203602703 5 P68371 1 +Gap junction assembly 0.5842503542121078 1.2964184234366225 0.1948313681862918 1.0 0.4211997203602703 5 P68371 1 +Activation of ampk downstream of nmdars 0.5842503542121078 1.2964184234366225 0.1948313681862918 1.0 0.4211997203602703 5 P68371 1 +Glycosphingolipid metabolism 0.493284052718719 1.2918374000299289 0.1964134603665392 1.0 0.4211997203602703 15 P07602,P10619,P16278,O43681 4 +S phase 0.3187934263888173 1.2898809457970588 0.1970919974280565 1.0 0.4211997203602703 88 Q9Y619,P60900,P20618,Q14566,Q9NR33,P61289,P49721,O75832,P09884,P41440,Q9NRF9,P28074 12 +Transport of inorganic cations anions and amino acids oligopeptides 0.5531809281645848 1.2872361544195388 0.1980119892107945 1.0 0.4224264640840282 10 Q70HW3 1 +Binding and uptake of ligands by scavenger receptors 0.5919944802941168 1.2823450393647102 0.1997216349210901 1.0 0.423520993990318 8 Q8WTV0 1 +Nuclear import of rev protein 0.3993808893752121 1.2793227234077946 0.2007834338643475 1.0 0.4242333375639079 32 P55735,Q92621,Q8NFH4,P62826,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 8 +Diseases of carbohydrate metabolism 0.6098263237566787 1.2791610771627009 0.2008403391939919 1.0 0.4242333375639079 7 P15586,P16278 2 +Glyoxylate metabolism and glycine degradation 0.490241697179416 1.2729028755384697 0.2030525087502055 1.0 0.4248178450743682 15 P09622,Q9NR77 2 +G protein mediated events 0.5293073409187214 1.2727130006911247 0.2031199026011556 1.0 0.4248178450743682 11 Q13557,O43865,Q13555 3 +Nuclear pore complex npc disassembly 0.4044560258210521 1.2709530260056217 0.2037453603781549 1.0 0.4249608444986136 31 P55735,Q92621,Q8TD19,Q8NFH4,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1 9 +Dna replication 0.3139761918640942 1.2707776782849216 0.2038077519534167 1.0 0.4249608444986136 82 Q9Y619,P60900,P20618,Q14566,P61289,P49721,O75832,P09884,P41440,Q9NRF9,P28074 11 +Smooth muscle contraction 0.4939977638232564 1.25891515438846 0.2080609794864631 1.0 0.4305575623762104 14 P06753,P09493,P67936 3 +Synthesis of pips at the early endosome membrane 0.4814262321177194 1.253498480692249 0.2100243516523434 1.0 0.4320141086461997 3 Q99570 1 +Tnf signaling 0.6165840390461574 1.2301041914184023 0.2186580907038569 1.0 0.4449120371604891 6 Q9Y6K9,O95429,O15111 3 +E2f enabled inhibition of pre replication complex formation 0.5691748438442905 1.2240777023216587 0.2209229166671273 1.0 0.4470593534915911 5 Q9Y619,P06493,O43913 3 +Organelle biogenesis and maintenance 0.3145598249415765 1.2168036603485652 0.2236789270347545 1.0 0.4509740575939379 91 O94927,A6NIH7,P63167,P43034,Q9BUR5,Q86X55,Q13505,Q15154,P49368,Q96CS2,Q92973,O43805,P00367,O43924,Q8IYI6,O95684,Q96KP1,Q9H6D7,Q9Y512,P00846,P68371,P56134,Q9BUF5,A0AVF1,Q9NV70,Q10713 26 +Gene silencing by rna 0.3658182289670201 1.2106235911659138 0.2260396985611468 1.0 0.4539397303548004 47 P55735,Q9Y2W6,O75569,Q92621,P30876,Q8NFH4,P62826,Q99598,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 12 +Pi3k akt signaling in cancer 0.517840237593199 1.2088988568069716 0.2267017054209126 1.0 0.4540653136313753 11 P49815,P84095,P31751,O15111,Q06124 5 +Lysosome vesicle biogenesis 0.4934183506152497 1.191510832571762 0.2334531066216296 1.0 0.4641995105577912 12 P05067 1 +Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0.4232296492389232 1.185891065622397 0.2356653219237339 1.0 0.4677692003676497 2 P63000 1 +Regulation of plk1 activity at g2 m transition 0.3828284638414246 1.168042086199068 0.2427897890364441 1.0 0.4786028599971283 36 O94927,P63208,Q15154,O43805,P68371,P63167,P07437,P43034,O95684,O14965,Q96CS2,Q9H6D7,P61163,P62140 14 +Translocation of slc2a4 glut4 to the plasma membrane 0.3779581220134008 1.1619181974611656 0.2452686945794584 1.0 0.4816485144420463 39 P68371,Q9Y4I1,Q8IYI6,Q9BUF5,Q9BZE9,Q9UIQ6,Q96KP1,P31751,Q9NV70 9 +Initiation of nuclear envelope ne reformation 0.4599927026691389 1.16191365332407 0.2452705405814044 1.0 0.4816485144420463 17 Q14739,O75531 2 +Runx2 regulates osteoblast differentiation 0.5121839317228716 1.1616246071181384 0.2453879822120921 1.0 0.4816485144420463 4 P28482,Q9UPW6 2 +Visual phototransduction 0.5651319343111618 1.152016922890657 0.2493141193491479 1.0 0.4872634925171382 8 P50579 1 +Role of second messengers in netrin 1 signaling 0.4172733289212527 1.1491839905193133 0.2504801208778497 1.0 0.4888459827089756 2 Q00169 1 +Disorders of transmembrane transporters 0.3244485587648046 1.139775976105561 0.2543796448884481 1.0 0.4943468453072957 74 P60900,P55735,P20618,Q92621,Q8NFH4,P61289,P55072,P53985,P49721,O75832,Q5SRE5,Q8N1F7,Q8NFH3,Q9BTX1,P28074,Q9UBV2 16 +Gaba synthesis release reuptake and degradation 0.4136333553937883 1.1267665649988885 0.2598411903030897 1.0 0.5035340580449705 2 P11142 1 +Ovarian tumor domain proteases 0.5399253688315754 1.1170233030984742 0.2639843615979691 1.0 0.5086889664500192 9 Q9Y6K9,Q96FW1,P61586,P55072,P06493 5 +Signaling by erbb2 0.4983065190427902 1.1003023728094523 0.2712003986525972 1.0 0.5218610756681115 11 P61586,P31751 2 +Slc mediated transmembrane transport 0.4295849549048476 1.0982113260937942 0.272112221673543 1.0 0.5221510043861551 20 Q9UBX3,Q15043,Q70HW3 3 +Beta catenin independent wnt signaling 0.33287552713926 1.0887016218035133 0.2762854863928901 1.0 0.5279438542215114 54 P60900,P07737,P61586,P61289,P49721,O75832,P28074 7 +Viral messenger rna synthesis 0.3740911781996668 1.0799049287379172 0.2801845182492763 1.0 0.5316851215873782 35 P55735,Q92621,P30876,Q8NFH4,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1 9 +Heme biosynthesis 0.5824675923548608 1.0772748651597162 0.2813574878243787 1.0 0.5324447907517899 6 P36551,P22830 2 +Interleukin 1 signaling 0.3503904637640286 1.0538427624193956 0.2919549117558873 1.0 0.5479646223379991 47 P60900,P20618,Q9Y6K9,P61289,P49721,O75832,O15111,P28074,P05067 9 +Peptide hormone metabolism 0.4536154566205477 1.045221155578971 0.2959207679548743 1.0 0.5508864228413671 15 Q9Y4I1,Q8IYI6,Q8TAG9,Q96KP1,Q9NV70,P62873,P67812 7 +Plasma lipoprotein clearance 0.4624412398791185 1.0370124611093263 0.2997300497737665 1.0 0.5564676972795773 13 Q8WTV0,O15118 2 +Hur elavl1 binds and stabilizes mrna 0.5730626383771722 1.0352929737439966 0.3005321101695379 1.0 0.5572027772332515 6 Q05655,Q01105,P39687 3 +Sumoylation of rna binding proteins 0.3757243786792811 1.0264268395822873 0.3046904322522445 1.0 0.5614445133419994 31 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 7 +Antigen presentation folding assembly and peptide loading of class i mhc 0.4505187539615216 1.0260542622865978 0.304866007609176 1.0 0.5614445133419994 15 P55735,Q9NZ08,P10321 3 +Unwinding of dna 0.5207441759078634 1.020262789163004 0.3076038460344366 1.0 0.5657271806424222 9 P33991,Q9BRT9,Q14566 3 +Amyloid fiber formation 0.5690696473164515 1.0175022241182394 0.3089145747623947 1.0 0.5673772377162056 6 P05067 1 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3886351817601721 1.0155211271973563 0.3098574807947933 1.0 0.5683482134364392 26 Q13126 1 +Synthesis of pips at the golgi membrane 0.536607739935988 1.0140933783373451 0.3105381973689469 1.0 0.5688363241524635 8 P42356,Q01968,O00443,Q99570,Q10713 5 +Opioid signalling 0.4240555109114487 1.0116212912000777 0.3117191618392267 1.0 0.5702382533912255 19 Q13557,O43865,Q00535,Q13555 4 +Trans golgi network vesicle budding 0.3668117157077676 1.0076415292318477 0.3136265843853028 1.0 0.5722016938519088 34 O14976,P15586,O43493,P11717,O75976,Q99523,P05067,Q9Y5X1 8 +Interleukin 12 signaling 0.3818309767531446 0.987862003213582 0.3232202365192411 1.0 0.584677032468448 27 Q13126 1 +Trna processing in the nucleus 0.3539337100880659 0.9838146779652622 0.3252066410611172 1.0 0.5855394563607766 42 P55735,Q92621,Q5KU26,Q8NFH4,P62826,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 9 +Tnfr1 induced nfkappab signaling pathway 0.5185858646855659 0.982084107025167 0.3260584144749514 1.0 0.5855394563607766 5 Q9Y6K9,O15111 2 +Slbp dependent processing of replication dependent histone pre mrnas 0.475796287595249 0.974825916058074 0.3296466194434577 1.0 0.5900008591786962 4 Q09161,P62318 2 +Nuclear envelope breakdown 0.3545589959198293 0.9735845279126156 0.3302628716102322 1.0 0.5900008591786962 41 P55735,Q8NFH4,Q5SRE5,O75531 4 +Cdt1 association with the cdc6 orc origin complex 0.3567754305526139 0.9661393880265612 0.333974437486694 1.0 0.5950817249762911 39 P60900,P61289,P49721,O75832,Q9Y619,P28074 6 +Insulin receptor signalling cascade 0.5566962571605102 0.9625306497133732 0.3357831147937529 1.0 0.5975284481154721 6 Q99570,Q06124,P31751,P28482 4 +Peroxisomal lipid metabolism 0.4724212472124011 0.9572063241784626 0.3384631256404731 1.0 0.5984167633746509 11 O15254,Q9UKG9 2 +Activation of nmda receptors and postsynaptic events 0.4214760188233691 0.9513710645819066 0.3414160435955897 1.0 0.6013129805046844 18 Q13555,Q13557,P68371 3 +Sphingolipid metabolism 0.3825933658099879 0.944761352511285 0.3447807267131462 1.0 0.6057035510416197 25 P06280,Q06136,P07602,O43681,P10619,O15269,P16278,Q9NZJ7 8 +Peroxisomal protein import 0.4039212050077427 0.9200027221944757 0.3575713366862731 1.0 0.6234946009178399 20 O15254,O00116,Q9UKG9,P50542 4 +Cytosolic iron sulfur cluster assembly 0.5469709159370806 0.9195290252741748 0.3578189310366997 1.0 0.6234946009178399 6 Q96T76,Q9Y5Y2,P28340 3 +Mitotic g2 g2 m phases 0.2925507541833437 0.915299032556118 0.3600346668647949 1.0 0.6247691446400091 88 P60900,O94927,Q13200,P63167,P43034,Q14997,O14965,P06493,P28072,P14635,P49720,Q15154,O00231,P61289,Q9UL46,P49721,O75832,Q96CS2,P25788,P28074,P61163,P20618,P63208,O43805,O14980,P24941,O95684,Q9ULW0,Q9H6D7,Q99996,P62140,Q13885,O43242,P68371,P07437,Q9UNM6,O75330,Q9BUF5,Q96CW5,P28070,Q9BSJ2 41 +Clec7a dectin 1 signaling 0.3340147035967608 0.912989223103813 0.3612482095253684 1.0 0.6250095125710031 48 P60900,P20618,Q9Y6K9,O43865,P61289,P49721,O75832,P28074 8 +Formation of tubulin folding intermediates by cct tric 0.4403266070580469 0.9063184102516684 0.3647673437968159 1.0 0.629510434829222 13 P68371,Q9BUF5,P17987,P49368,Q99832,Q13885 6 +Syndecan interactions 0.4184045018205923 0.9013144231071536 0.3674211672756577 1.0 0.6310783191875671 3 P05556,Q9Y296 2 +Orc1 removal from chromatin 0.3298568469892902 0.8960957143206211 0.3702016457924433 1.0 0.6333125411810876 49 P60900,Q14566,P61289,P49721,O75832,Q9Y619,P28074 7 +Antigen processing ubiquitination proteasome degradation 0.2891711751980493 0.8931071319618659 0.3717998040342629 1.0 0.635254459694905 85 P60900,P29144,Q8TBC4,P55786,Q8NEZ5,Q9C0C9,Q5T4S7,P61289,Q13867,P49721,O75832,P19474,P25788,P28074,P20618,P63208,A0AVT1,Q7Z6E9,P30260,Q9UIQ6,Q8IWV8,Q15369 22 +Fc epsilon receptor fceri signaling 0.3211097228334779 0.8903892888792472 0.373256891752846 1.0 0.6369508152797323 52 P60900,P20618,Q9Y6K9,O43865,P61289,P49721,O75832,P28074 8 +Mrna splicing minor pathway 0.3537702697958044 0.8882679783933488 0.37439662010939 1.0 0.6380460343819595 33 Q6P2Q9,P62875,Q9Y333,Q9Y3B4,P30876,P55769,Q01130,P62314,P62316,Q09161,Q96DI7,P62318 12 +Interactions of vpr with host cellular proteins 0.3517340170644393 0.8821263975664995 0.3777084585293444 1.0 0.6419124852512756 35 P55735,Q8NFH4,Q5SRE5,O75531 4 +Sumoylation of chromatin organization proteins 0.352285332498756 0.8806234262318929 0.3785216747889413 1.0 0.641942815587673 34 P55735,Q15022,Q9UPW6,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 9 +Cell cycle mitotic 0.2473875536666418 0.8797294614220531 0.3790058853063729 1.0 0.6419704625189427 244 P60900,O94927,P63167,P43034,Q92621,P11802,P42695,P50748,Q5SRE5,O14965,Q9NRF9,P35250,P55735,Q15154,P04818,P61289,P62826,Q9BRT9,P49721,Q96CS2,P25788,P41440,O75832,P28074,P61163,Q01105,Q92973,Q08379,P20618,P63208,O43805,P33991,Q8TD19,Q14566,Q8WUX9,Q9NR33,O95684,Q8N1F7,P31751,P09884,Q9ULW0,Q9H6D7,Q9P258,P04183,Q86XL3,Q86XI2,P07437,O75531,P68371,P28340,P30260,Q8NFH4,Q9BUF5,Q96CW5,Q8NBT2,Q8NFH3,P49792,Q07864,Q9BTX1,Q14739,Q9Y619,Q6IBW4 62 +Downstream signaling events of b cell receptor bcr 0.3422300781983891 0.8733302736374603 0.3824830840863067 1.0 0.6462645213872079 42 P60900,P20618,Q9Y6K9,P61289,P49721,O75832,P28074 7 +Global genome nucleotide excision repair gg ner 0.3490556123379297 0.8659679954565737 0.3865077129893743 1.0 0.6514601747191912 36 P09874,P28340,Q9NR33,Q7L5N1,Q9BT78,P41440,Q9NRF9,P35250,Q9UBW8 9 +Maturation of sars cov 2 nucleoprotein 0.4934230825427868 0.863318326594482 0.3879624706784801 1.0 0.6529998134931299 5 P49840,Q99873,Q96SB4 3 +Anchoring of the basal body to the plasma membrane 0.3562589229350769 0.862571570442988 0.3883730669171967 1.0 0.6529998134931299 31 O94927,Q15154,O43805,P68371,P63167,P43034,O95684,Q96CS2,Q9H6D7 9 +Negative regulators of ddx58 ifih1 signaling 0.5180872455580433 0.8546542482119949 0.3927425859568882 1.0 0.6595383450830486 7 Q7Z434,Q13526,Q86UT6,Q15366,Q14258 5 +Hcmv early events 0.328008461323621 0.8523901084251525 0.3939976083765075 1.0 0.6601070691456857 48 P55735,Q15022,P68371,P63167,Q92621,O75530,Q8NFH4,Q9BUF5,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 12 +Circadian clock 0.4695484026152193 0.8470055943195134 0.3969920032562068 1.0 0.6606006083435517 10 Q9BWF3,P63208,Q86X55,P43490,P62140 5 +Cellular response to hypoxia 0.3437058739632587 0.8468835132801955 0.397060052811188 1.0 0.6606006083435517 39 P60900,P20618,P61289,P49721,O75832,P28074 6 +Regulation of runx3 expression and activity 0.3474712952064617 0.8448581968513923 0.3981900168368202 1.0 0.6606006083435517 35 P60900,P61289,P49721,O75832,P28074 5 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.4849748581754523 0.8419120881855843 0.3998371635015898 1.0 0.6615537585330478 9 P15289,Q9BU89,P13639,O43681,O60725,Q9HA64 6 +Rho gtpases activate iqgaps 0.4329776173198987 0.8405891849721274 0.4005781195531002 1.0 0.6615537585330478 12 Q13576,P68371,Q9BUF5,P60953,P35222,Q13885 6 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.4045026747109749 0.8403837184157579 0.4006932750298562 1.0 0.6615537585330478 18 Q06481,O43493,P05067 3 +Dna damage reversal 0.4485355173912539 0.8368875759794969 0.4026557645320878 1.0 0.662555072682148 4 Q9H1I8,Q8N3C0 2 +Keratan sulfate keratin metabolism 0.4855725670875089 0.8266678869014128 0.4084253277020457 1.0 0.6705110560437197 5 P16278 1 +Parasite infection 0.3759356774843868 0.8264266158587269 0.4085621303590012 1.0 0.6705110560437197 23 Q9UQB8,Q9Y4I1,Q8WUW1,Q7L576,Q96F07,P35579 6 +Synthesis of substrates in n glycan biosythesis 0.4217979128575378 0.8225073280985392 0.410788217706842 1.0 0.6733589422864842 14 P10619,P16278 2 +Translesion synthesis by polh 0.4250823378554537 0.817369522187464 0.4137172875096981 1.0 0.675007283402321 13 P41440,P35250,P55072 3 +Asymmetric localization of pcp proteins 0.3422328309183101 0.8139180747032628 0.4156918854082057 1.0 0.675007283402321 37 P60900,P61289,P49721,O75832,P28074 5 +Degradation of axin 0.3425279121749943 0.8085972607775495 0.4187468409122572 1.0 0.6791024417631405 36 P60900,P61289,P49721,O75832,P28074 5 +Mismatch repair 0.4618617151561804 0.8074490142752667 0.4194078378519128 1.0 0.6793713737105365 10 P52701,P12004,Q9UQ84,P28340 4 +Cross presentation of soluble exogenous antigens endosomes 0.3411876308454964 0.8046863724516546 0.4210006854828427 1.0 0.6811473354745994 37 P60900,P61289,P49721,O75832,P28074 5 +C type lectin receptors clrs 0.318231938805401 0.8031455938972202 0.4218905874263754 1.0 0.681320994430538 50 P60900,P20618,Q9Y6K9,O43865,P61289,P49721,O75832,P28074 8 +Ros and rns production in phagocytes 0.4770077733831057 0.80278121915564 0.4221011991734382 1.0 0.681320994430538 9 Q93050 1 +Hemostasis 0.2749262071672118 0.801543472070845 0.4228170877598121 1.0 0.6816745527690508 117 P42785,Q9NZJ7,Q00535,P07737,O94919,P14174,P61586,Q14807,Q8NBX0,P07602,P84095,P05067,Q92896,Q05655,Q06481,P13473,O43852,P68371,Q9BUF5 19 +Ncam signaling for neurite out growth 0.5191603988935762 0.7979548956123369 0.4248966650966932 1.0 0.6834211307299685 6 Q01082,O15020,Q13813,P28482 4 +Platelet calcium homeostasis 0.3988745448526933 0.7945668573973814 0.4268655037184834 1.0 0.6849818375459172 3 P20020,P30626 2 +Reduction of cytosolic ca levels 0.3988745448526933 0.7945668573973814 0.4268655037184834 1.0 0.6849818375459172 3 P20020,P30626 2 +Transcriptional regulation by mecp2 0.4166855029418931 0.7923292906449158 0.428168697036881 1.0 0.686270388241356 14 Q13555,Q14739 2 +Runx2 regulates bone development 0.475850093273219 0.781621165604603 0.434437244270788 1.0 0.6944229141931386 5 P28482,Q9UPW6 2 +Regulation of ras by gaps 0.3380362517600163 0.7769394413904421 0.437194499925051 1.0 0.6950531331369293 37 P60900,P61289,P49721,O75832,P28074 5 +Degradation of dvl 0.3380362517600163 0.7769394413904421 0.437194499925051 1.0 0.6950531331369293 37 P60900,P61289,P49721,O75832,P28074 5 +Hcmv late events 0.3396894690528601 0.7720538186779727 0.4400825526753067 1.0 0.6988347942945842 34 P55735,Q92621,Q8WUX9,Q8NFH4,Q99816,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1 10 +Homologous dna pairing and strand exchange 0.4196480451421281 0.7650719260207303 0.4442287159975748 1.0 0.7021679704477796 12 Q9UQ84 1 +Hdr through single strand annealing ssa 0.4196480451421281 0.7650719260207303 0.4442287159975748 1.0 0.7021679704477796 12 Q9UQ84 1 +Interactions of rev with host cellular proteins 0.3372172666469543 0.7560666466372553 0.4496092380588139 1.0 0.7063014235785824 35 P55735,Q92621,Q8NFH4,P62826,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 8 +Regulation of mecp2 expression and activity 0.4349677575903761 0.754123725095216 0.4507749325039401 1.0 0.7063014235785824 11 Q13555,Q14739 2 +Pka activation in glucagon signalling 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.7063014235785824 2 P10644 1 +Creb1 phosphorylation through the activation of adenylate cyclase 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.7063014235785824 2 P10644 1 +Pka mediated phosphorylation of creb 0.3510919920582463 0.7481038049568752 0.4543975471333277 1.0 0.7063014235785824 2 P10644 1 +Auf1 hnrnp d0 binds and destabilizes mrna 0.3297191996456992 0.7438088383504222 0.4569921323643848 1.0 0.7063014235785824 41 P60900,P61289,Q14103,P49721,O75832,P28074 6 +Dual incision in tc ner 0.336129918188802 0.7350284211085129 0.462322185273101 1.0 0.7063014235785824 32 P28340,P30876,Q9NR33,Q07864,Q93009,P41440,Q9NRF9,P35250 8 +Synthesis of very long chain fatty acyl coas 0.4905129181352334 0.7308866929255367 0.4648483647232413 1.0 0.7078490082134152 7 Q53GQ0,P33121,Q9NZ01 3 +Switching of origins to a post replicative state 0.3001960307750286 0.7293392760360179 0.4657941526949487 1.0 0.7082466457311358 54 P60900,Q14566,P61289,P49721,O75832,Q9Y619,P28074 7 +Snrnp assembly 0.3280603807445642 0.7287707199788152 0.4661419249965128 1.0 0.7082466457311358 41 P55735,Q8NFH4,P62316,P62314,Q5SRE5,Q9BTX1,Q09161,P62318 8 +Aquaporin mediated transport 0.4628514660055096 0.7220958847442142 0.4702355281540136 1.0 0.7133746607332476 5 P62873,Q99797 2 +Adaptive immune system 0.2587178280844657 0.7163001806769181 0.473806015263192 1.0 0.7175075639526484 180 P60900,P10321,P63167,Q99538,P55786,P55735,Q9Y6K9,Q9C0C9,Q5KU26,Q14807,P61289,P49721,O75832,P19474,P28074,P20618,P04439,O43865,Q9NZ08,A0AVT1,P10619,P31751,O15111,O95487,P68371,Q9UIQ6,Q8IWV8,Q9BUF5,Q15369,P09429,P53634 31 +Cdc42 gtpase cycle 0.3382887864912962 0.714328486754125 0.475024081199612 1.0 0.7185590291134153 31 Q9UQB8,Q14739 2 +Translesion synthesis by polk 0.4426776279805304 0.7101001780321402 0.4776420159309396 1.0 0.7196581572048596 10 P41440 1 +Rhov gtpase cycle 0.4053565395107126 0.7043910569174887 0.4811892738161289 1.0 0.7223103760128327 13 P06753,P67936 2 +Hsf1 dependent transactivation 0.3969223238604067 0.7008628019871416 0.4833886405670524 1.0 0.723237966039254 15 Q15185,Q13555 2 +Intracellular signaling by second messengers 0.2728113671750342 0.6961632728393218 0.4863265853009597 1.0 0.7255562175945685 82 P49815,P60900,P20618,O43865,Q13555,O75530,P61289,P49721,O75832,P31751,O15111,P28074 12 +Plasma lipoprotein assembly remodeling and clearance 0.3915608523133439 0.6950784607546203 0.4870061323582675 1.0 0.7255562175945685 16 Q8WTV0,O15118 2 +Transport of mature mrnas derived from intronless transcripts 0.327731666571229 0.6950030207991107 0.4870534084581615 1.0 0.7255562175945685 38 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1,Q09161 8 +Trna processing 0.2939946625399071 0.6896005584828306 0.4904454160777654 1.0 0.7298168230571519 58 P55735,Q92621,Q5KU26,Q8NFH4,Q9NPF4,P62826,Q8NFH3,Q08J23,Q8N1F7,Q5SRE5,P49792,Q9BTX1 12 +Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.4931581321263533 0.6869452833535504 0.4921172095106214 1.0 0.7315111716669259 6 Q15067 1 +Transferrin endocytosis and recycling 0.4213377804731775 0.6822006076887949 0.4951121104831069 1.0 0.7351664670809769 11 Q93050 1 +Microrna mirna biogenesis 0.436534285404243 0.6794244943378306 0.4968689342215477 1.0 0.7363131465686737 10 P62875,O75569,P30876,P62826,P62487 5 +Metabolism of polyamines 0.3259242222880008 0.6792843559646805 0.496957706794892 1.0 0.7363131465686737 38 P60900,P61289,P49721,O75832,P28074 5 +Synthesis of pa 0.4643659414909965 0.6741279661950049 0.500229961011168 1.0 0.7401091821606794 8 Q6UWP7,Q9NPH0,Q9HCL2 3 +Activation of atr in response to replication stress 0.3730105009432616 0.6729790788130292 0.500960600894401 1.0 0.7401091821606794 19 O43913,P33991,P24941,Q14566,P49736,Q9Y619,P35250,O75419 8 +Metabolism of folate and pterines 0.464002391217124 0.6724788542529699 0.501278897486658 1.0 0.7401091821606794 8 Q9H2D1,P34896,P41440 3 +Diseases of programmed cell death 0.3504949638024344 0.6715576305292611 0.5018653591434101 1.0 0.7401091821606794 24 O75530,P09884,P05067,P26358 4 +Stabilization of p53 0.3252028761926567 0.6655344319369345 0.50570872827238 1.0 0.7433660372230588 37 P60900,P61289,P49721,O75832,P28074 5 +Interleukin 1 family signaling 0.3067040428908227 0.6635606915424006 0.5069715229283229 1.0 0.7433660372230588 49 P60900,P20618,Q9Y6K9,P61289,P49721,O75832,O15111,P28074,P05067 9 +Mapk family signaling cascades 0.2730368855182264 0.6635032178335901 0.5070083192882402 1.0 0.7433660372230588 86 P60900,P20618,Q13555,O43924,P61289,P49721,O75832,O60725,P28074,Q9Y4G8 10 +Death receptor signalling 0.3656732784498226 0.6616456957023679 0.5081983147855964 1.0 0.7433660372230588 20 P61586,Q92542,O95429 3 +Ikk complex recruitment mediated by rip1 0.4488150442112661 0.658900823029161 0.5099594573287352 1.0 0.7433660372230588 5 Q9Y6K9 1 +G beta gamma signalling through cdc42 0.4119891106911246 0.6575375463707459 0.5108353370215835 1.0 0.7433660372230588 4 P60953 1 +Fceri mediated nf kb activation 0.3169888330217183 0.65441275678326 0.5128459178802818 1.0 0.7433660372230588 43 P60900,P20618,Q9Y6K9,P61289,P49721,O75832,P28074 7 +Tcr signaling 0.3098630747692305 0.6532273502665624 0.5136097204425703 1.0 0.7433660372230588 47 P60900,P20618,Q9Y6K9,P61289,P49721,O75832,P28074 7 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.3135955716887688 0.653186867707741 0.5136358153484608 1.0 0.7433660372230588 45 P60900,P61289,P49721,O75832,O14965,P28074 6 +Transcriptional regulation by small rnas 0.3229066788374525 0.653183854779761 0.5136377574981486 1.0 0.7433660372230588 38 P55735,Q92621,P30876,Q8NFH4,P62826,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1 9 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.4089212257063882 0.6428993931493485 0.5202893832215565 1.0 0.7498288169957726 4 P11802,P24941 2 +Cyclin a cdk2 associated events at s phase entry 0.3151244477487733 0.6375250785539143 0.5237828798448492 1.0 0.7524922629812912 43 P60900,P20618,P61289,P49721,O75832,P28074 6 +Signaling by notch4 0.3173300307988512 0.6327848104914424 0.5268741772481347 1.0 0.7539538046012316 41 P60900,P61289,P49721,O75832,P28074,Q92542 6 +Mitophagy 0.3952956338849286 0.6305026446806021 0.5283657730081477 1.0 0.7543369829002899 12 Q9NS69 1 +Regulation of pten stability and activity 0.3175822939880093 0.6246288259508177 0.5322146960216987 1.0 0.7561118033330785 40 P60900,P20618,P61289,P49721,O75832,P28074 6 +G1 s dna damage checkpoints 0.3193773806248711 0.6228975323458152 0.5333518597411318 1.0 0.7561118033330785 38 P60900,P61289,P49721,O75832,P28074 5 +Insulin receptor recycling 0.4245749289256949 0.6205455348765119 0.5348986850262367 1.0 0.7573591288503579 10 Q93050 1 +Activation of kainate receptors upon glutamate binding 0.3644488579940351 0.6127992941482397 0.5400090576543521 1.0 0.7601080541903381 3 P62873,Q9UBI6 2 +Signaling by insulin receptor 0.3773398233178732 0.6106505839131053 0.5414309272153983 1.0 0.7601080541903381 16 Q9Y487,P31751,Q93050 3 +Met activates ptpn11 0.3631988883154982 0.60640784817109 0.5442439582303567 1.0 0.7601080541903381 3 Q06124 1 +O linked glycosylation of mucins 0.4003944437547598 0.6026409075192566 0.546747600512107 1.0 0.7601080541903381 4 Q10472 1 +O linked glycosylation 0.4003944437547598 0.6026409075192566 0.546747600512107 1.0 0.7601080541903381 4 Q10472 1 +Mrna decay by 5 to 3 exoribonuclease 0.4339295355601568 0.5974471090284388 0.5502089095012679 1.0 0.7601080541903381 9 P62310 1 +Activation of nima kinases nek9 nek6 nek7 0.3979208292749202 0.5910869458570956 0.5544621660660185 1.0 0.7601080541903381 4 Q8TD19,P06493 2 +Hedgehog off state 0.2991228556726999 0.5901127901268418 0.5551150345444829 1.0 0.7601080541903381 49 P60900,P20618,P68371,P61289,P49721,O75832,P28074 7 +Acyl chain remodelling of pg 0.322634017207155 0.5852554940936733 0.5583759357144413 1.0 0.7601080541903381 2 Q8NF37 1 +Hedgehog ligand biogenesis 0.3139174601493111 0.5841296206637435 0.559133107619437 1.0 0.7601080541903381 39 P60900,P61289,P49721,O75832,P28074 5 +Defective cftr causes cystic fibrosis 0.3127376928351609 0.5826799432832496 0.5601087775411311 1.0 0.7601080541903381 40 P60900,P61289,P49721,O75832,P28074 5 +Abc transporter disorders 0.3127376928351609 0.5826799432832496 0.5601087775411311 1.0 0.7601080541903381 40 P60900,P61289,P49721,O75832,P28074 5 +Degradation of gli1 by the proteasome 0.313466553717287 0.5802919200353075 0.5617177753022413 1.0 0.7612186288875536 39 P60900,P61289,P49721,O75832,P28074 5 +Signaling by ntrk2 trkb 0.4305646644948571 0.5788018610177114 0.5627228752781248 1.0 0.761396237555806 5 Q00535 1 +Selective autophagy 0.316590236759903 0.5752540512814651 0.5651194921443559 1.0 0.7638856583468534 32 P08670,P68371,P63167,P50542,Q9BUF5,Q9NS69,P21796 7 +Signaling by braf and raf1 fusions 0.3326358928096268 0.5718025735613279 0.5674557335841588 1.0 0.766288648107742 25 Q13557,Q13555,Q96PU8 3 +The role of gtse1 in g2 m progression after g2 checkpoint 0.2990974063859977 0.5702700022762901 0.5684945835129995 1.0 0.7669366456045579 48 P60900,P20618,P68371,P61289,P49721,O75832,P28074 7 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4275924945430533 0.5684161539993832 0.569752424071905 1.0 0.7678785125998563 9 Q13555 1 +Homology directed repair 0.3151055648553653 0.5647669825073581 0.572232267492581 1.0 0.7697085009802168 33 O96028,P09874,Q9NR33,Q9UQ84,P41440,Q9NRF9,P35250 7 +Rho gtpases activate paks 0.3796203350807864 0.5622263007490624 0.5739618441727563 1.0 0.7697709190664924 13 P21333,P60660,P35580,P60953,P35579 5 +Vxpx cargo targeting to cilium 0.411425863579739 0.5572907551287926 0.5773287910875124 1.0 0.7712707900409612 10 Q8IYI6,Q96KP1 2 +Pkmts methylate histone lysines 0.3591194979467859 0.5551758325202902 0.5787743976503714 1.0 0.771347887052707 18 Q03164,Q9BZ95,O96028,Q15022,Q96KQ7,O75530,Q15047 7 +Prc2 methylates histones and dna 0.4610205071230643 0.5550163096955039 0.57888350473597 1.0 0.771347887052707 6 P26358 1 +Trafficking of ampa receptors 0.4105110607294169 0.5529547321702211 0.5802944078766146 1.0 0.771347887052707 10 Q13555 1 +Regulation of hsf1 mediated heat shock response 0.2883543496199567 0.5523029709807669 0.5807407954316854 1.0 0.771347887052707 52 P55735,Q92621,Q8NFH4,Q8NFH3,Q8N1F7,Q5SRE5,Q9BTX1,Q99615,O95429 9 +Regulation of hmox1 expression and activity 0.3025561100832806 0.5522753112971323 0.580759742948576 1.0 0.771347887052707 45 P60900,P61289,P09601,P49721,O75832,P28074 6 +Inactivation of cdc42 and rac1 0.3510954186346733 0.5454725866085564 0.5854285295780892 1.0 0.7738034128912702 3 P60953 1 +Interleukin 12 family signaling 0.3199999706106909 0.5369989836014075 0.5912683161322414 1.0 0.7777757715565055 30 Q13126 1 +Bbsome mediated cargo targeting to cilium 0.455988713447704 0.5350356762070754 0.5926251877121829 1.0 0.7780686675034593 6 P17987,P49368 2 +Nod1 2 signaling pathway 0.4200284085222629 0.5338311228513489 0.593458378949947 1.0 0.7784176825232575 5 Q9Y6K9 1 +Phase ii conjugation of compounds 0.3227848673389447 0.5307760300643732 0.595573992329077 1.0 0.7799149814073091 28 O14880,Q9NUJ1 2 +Dna double strand break repair 0.299552890661089 0.5254474720887123 0.5992721598648063 1.0 0.7824633477241284 45 P09874,O96028,Q9NR33,Q9UQ84,P78527,P41440,Q9NRF9,Q9UIG0 8 +Regulation of runx2 expression and activity 0.3048338297537061 0.5244514093056715 0.5999646077301626 1.0 0.7824633477241284 41 P60900,P61289,P49721,O75832,P28074 5 +Transcriptional regulation by runx2 0.2871545099297238 0.517784067370906 0.604608935866624 1.0 0.7862781611459793 51 P60900,P20618,Q9UPW6,P61289,P49721,O75832,P28074 7 +Processive synthesis on the lagging strand 0.4026293067128066 0.5159787490514983 0.6058692516146467 1.0 0.7871710352417568 10 P09884 1 +Scf skp2 mediated degradation of p27 p21 0.3043035938364797 0.51114596088313 0.6092488549502859 1.0 0.7908130832467287 40 P60900,P61289,P49721,O75832,P28074 5 +Pyruvate metabolism 0.3556061029648789 0.5087757682840643 0.6109094062404179 1.0 0.7919837515189017 17 Q16775,P09622 2 +Transcription coupled nucleotide excision repair tc ner 0.3017618005548425 0.5082111922396944 0.6113052426082484 1.0 0.7919837515189017 42 P28340,P30876,Q9NR33,Q7L5N1,Q9BT78,Q07864,P41440,Q9NRF9,P35250,Q9UBW8 10 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3407188495860237 0.5022530137626409 0.6154895559587319 1.0 0.7944042058093888 20 Q2TAA5,P16278,P10619,Q9BV10 4 +Hcmv infection 0.2803964941189008 0.4983737907446727 0.618220606387228 1.0 0.7947040014038484 53 P55735,Q15022,P68371,P63167,Q92621,O75530,Q8WUX9,Q8NFH4,Q9BUF5,Q99816,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1 15 +Tnfr2 non canonical nf kb pathway 0.300529860401774 0.4977355493588935 0.6186704481878664 1.0 0.7947040014038484 42 P60900,P20618,P61289,P49721,O75832,P28074 6 +Dectin 1 mediated noncanonical nf kb signaling 0.300529860401774 0.4977355493588935 0.6186704481878664 1.0 0.7947040014038484 42 P60900,P20618,P61289,P49721,O75832,P28074 6 +Intraflagellar transport 0.3667009139309921 0.4938912095537013 0.6213830130079239 1.0 0.7961106439070084 13 A0AVF1,Q9BUF5,P68371,P63167 4 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.4230204647216437 0.4932231231995631 0.6218549411501224 1.0 0.7961106439070084 8 Q86X55,O14965,P06493,Q99873,P14635 5 +Rho gtpase effectors 0.2554003438062192 0.4929648758613198 0.6220374056440208 1.0 0.7961106439070084 116 Q9UQB8,P63167,P43034,Q8WUW1,Q96F07,P35579,P55735,P07737,P21333,P61586,Q13526,Q7L576,P35580,P84095,Q05655,P60660,O43663,Q99570,Q9P258,P68371,Q8NFH4,Q9BUF5,Q8NBT2,Q8NFH3,O60879 25 +Downregulation of tgf beta receptor signaling 0.4342089814801141 0.4920888069078652 0.6226565646282982 1.0 0.7961106439070084 7 Q9Y4E8,O14980,P62140,Q9Y5K5 4 +Rhoh gtpase cycle 0.3309829736466088 0.4913279936311185 0.623194483641492 1.0 0.7961106439070084 22 Q9BZH6 1 +Negative regulation of notch4 signaling 0.3020691675532138 0.4851582205484196 0.627564115808573 1.0 0.8009469459435926 39 P60900,P61289,P49721,O75832,P28074 5 +Ptk6 regulates proteins involved in rna processing 0.3370308897156461 0.477122924729915 0.6332745911610558 1.0 0.8056842830825226 3 Q07666 1 +Rac3 gtpase cycle 0.3036931229555916 0.47496046440424 0.6348151531262585 1.0 0.8056842830825226 33 Q9UQB8,Q7L576,Q14739 3 +Mrna capping 0.3642761890791446 0.4683772048906867 0.6395148663375856 1.0 0.807932225244169 12 P62875,O00267,P30876,Q09161,P62487 5 +Prolactin receptor signaling 0.3330618867801861 0.4583771704070677 0.6466814904429623 1.0 0.815484379492412 3 P63208 1 +Chaperone mediated autophagy 0.4253154991208477 0.4568369916256504 0.647788215162648 1.0 0.8161298725465133 7 P13473,P08670 2 +Regulation of tp53 activity through phosphorylation 0.3189875429468294 0.4533972347083102 0.6502627273199946 1.0 0.8180474301148569 24 Q9UQ84,Q00535,Q13526,O14965 4 +Role of abl in robo slit signaling 0.3316782522343564 0.4519027943423518 0.6513390113067736 1.0 0.8180474301148569 3 O75122,Q01518 2 +Suppression of apoptosis 0.3999934918479279 0.4514084150370663 0.651695219471967 1.0 0.8180474301148569 5 P49840,P28482,P23246 3 +Rho gtpases activate wasps and waves 0.3360297006548037 0.4454279517461941 0.6560105160822454 1.0 0.8210333912273731 19 Q9UQB8 1 +G1 s specific transcription 0.3733680160041446 0.4434696150113863 0.6574260922966795 1.0 0.82148324101188 11 Q9Y619,P04818,P09884 3 +Transcriptional regulation by e2f6 0.4078832218106767 0.4311668509452728 0.6663470551717776 1.0 0.8247929958174798 8 O75530,Q96KQ7 2 +Signal attenuation 0.3270440251572286 0.4304550126830571 0.6668646849777449 1.0 0.8247929958174798 3 P27361,P28482 2 +Downstream signaling of activated fgfr1 0.3270440251572244 0.4304550126830385 0.6668646849777584 1.0 0.8247929958174798 3 Q06124,P19174 2 +Downstream signaling of activated fgfr2 0.3270440251572244 0.4304550126830385 0.6668646849777584 1.0 0.8247929958174798 3 Q06124,P19174 2 +Downstream signaling of activated fgfr3 0.3270440251572244 0.4304550126830385 0.6668646849777584 1.0 0.8247929958174798 3 Q06124,P19174 2 +Downstream signaling of activated fgfr4 0.3270440251572244 0.4304550126830385 0.6668646849777584 1.0 0.8247929958174798 3 Q06124,P19174 2 +Host interactions of hiv factors 0.2574200695763294 0.4292438254835714 0.6677457924876393 1.0 0.8247929958174798 94 P55735,P60900,P20618,P04439,O75531,Q92621,Q8NFH4,P61289,Q15369,P49721,O75832,Q5SRE5,Q9BTX1,P28074 14 +Transcriptional regulation of white adipocyte differentiation 0.3672055639127459 0.4149878683348712 0.6781507841546439 1.0 0.8301859543860576 11 Q86X55,P11802,O75448 3 +Neutrophil degranulation 0.2440669770705178 0.4147732390627318 0.6783079117104742 1.0 0.8301859543860576 172 P15586,P10321,P11717,P63167,P42785,O43681,O95298,Q9NZJ7,Q92542,O75131,Q93050,P14174,P61586,P07602,Q7L576,P84095,P30519,P20618,P04439,Q05655,P08236,O15260,P10619,P35573,P13473,P61916,P68371,P09429,P53634,P16278 30 +Mitotic prophase 0.2675785042980866 0.4102552744936807 0.681618697339551 1.0 0.8320114348308398 61 P55735,Q86XI2,O75531,Q6IBW4,Q92621,Q8NFH4,P42695,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1,Q01105,Q08379 14 +Signaling by interleukins 0.2537737885163729 0.4048683812057438 0.6855742611666802 1.0 0.8352547915792119 105 P60900,P20618,Q9Y6K9,O00170,P14174,P08670,P61289,P09601,P49721,O75832,O15111,P28074,P05067,Q13126 14 +Hedgehog on state 0.2902466595029647 0.4041503655069193 0.6861021502257811 1.0 0.8352547915792119 41 P60900,P61289,P49721,O75832,P28074 5 +Cytoprotection by hmox1 0.266581339901966 0.4011136264811521 0.6883364688469293 1.0 0.8364903766678362 64 P60900,P00403,Q86X55,P61289,P09601,P49721,O75832,P30519,P28074 9 +Metabolism of water soluble vitamins and cofactors 0.2923957335315115 0.3906128134103781 0.6960834529366342 1.0 0.8444089278771549 34 Q13057,P49327,P34897,P34896,Q96RQ3,O00763,P00387,P41440,Q9H2D1,P43490 10 +Glucagon signaling in metabolic regulation 0.3513245033112441 0.3868300863846516 0.6988820021458373 1.0 0.8463072435517112 4 P10644,P62873,Q9UBI6 3 +Vasopressin regulates renal water homeostasis via aquaporins 0.3513245033112441 0.3868300863846516 0.6988820021458373 1.0 0.8463072435517112 4 P10644,P62873,Q9UBI6 3 +Transcriptional regulation by runx3 0.2895278111231537 0.3853672360296792 0.6999653534692687 1.0 0.8468716622220781 39 P60900,P61289,P49721,O75832,P28074 5 +Apc c mediated degradation of cell cycle proteins 0.2704256630219312 0.3827445439416299 0.7019091834514191 1.0 0.847728344802242 52 P60900,P61289,P49721,O75832,O14965,P28074 6 +Methylation 0.3952254641909785 0.3814455910627633 0.7028726367423026 1.0 0.8481453453038164 8 Q9UI30,P31153,Q99707,P78417,P23526,Q9NZL9,P51580 7 +Citric acid cycle tca cycle 0.3245588547224851 0.3800564364286998 0.7039035224020127 1.0 0.8486429110154318 19 P09622 1 +Metabolism of vitamins and cofactors 0.2852140687940045 0.3721321929471088 0.7097944283069906 1.0 0.852001710968671 42 P35270,Q9H2D1,P43490,P41440 4 +Nucleotide excision repair 0.2744056151403045 0.3651279629632567 0.7150158883461071 1.0 0.8528590188437596 49 P09874,P28340,P30876,Q9NR33,Q7L5N1,Q9BT78,Q07864,P41440,Q9NRF9,P35250,Q9UBW8 11 +Rho gtpases activate formins 0.262455927318283 0.3627860309218814 0.7167647277124869 1.0 0.8536468805742465 59 P55735,P07737,P68371,P63167,P43034,P61586,Q8NFH4,Q9BUF5,Q8NBT2,P50748,Q8NFH3,P49792,Q9P258,O60879 14 +Processive synthesis on the c strand of the telomere 0.3891132818371756 0.3582202838364994 0.7201784688037443 1.0 0.8569686549858951 8 P28340 1 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.2836563196783294 0.3461235075001876 0.7292498976121986 1.0 0.8655111241556543 40 P60900,P61289,P49721,O75832,P28074 5 +Glycolysis 0.2750184727346688 0.3421405620582525 0.7322451132922112 1.0 0.8675650219662469 47 P55735,Q92621,Q8NFH4,P52789,Q8N1F7,Q8NFH3,Q5SRE5,P49792,Q9BTX1 9 +Golgi associated vesicle biogenesis 0.2947011395155134 0.3392185460175102 0.7344450989839248 1.0 0.8694207729128084 27 O14976,Q01968,O43493,O75976,P11717,Q99523,Q14789,Q9BXS5,Q9Y5X1 9 +Signaling by hedgehog 0.2597148989500625 0.3269780959608375 0.7436844523132695 1.0 0.8741807473039928 54 P60900,Q13200,Q14997,P28072,P49720,O00231,P61289,Q8NCM8,Q9UL46,P49721,O75832,P25788,P28074,P48729,P20618,P63208,Q9UBV2,Q13885,O43242,P68371,Q9UNM6,Q9BUF5,P55072,P10644,P28070 25 +Biotin transport and metabolism 0.3804638404926617 0.3262958608547748 0.744200519570746 1.0 0.8741807473039928 8 O00763,Q96RQ3 2 +Degradation of the extracellular matrix 0.3800812540564062 0.3249102928439762 0.74524896661688 1.0 0.8746634578257992 8 Q92542,O15484 2 +Rho gtpases activate pkns 0.3081814486267696 0.3131067740391819 0.7541995427409127 1.0 0.881711594385137 20 P35580,P61586,P60660 3 +E2f mediated regulation of dna replication 0.3399063999021922 0.2968759837388526 0.7665611922106401 1.0 0.8897816884204723 11 P09884 1 +Protein protein interactions at synapses 0.3249263205923937 0.2927184414536762 0.7697373727742955 1.0 0.8919591853431871 13 P10586,P41440 2 +Raf independent mapk1 3 activation 0.3874764259444552 0.2889844152992813 0.7725933037851898 1.0 0.8945130909647936 6 Q06124,P27361,P28482,P06493 4 +Advanced glycosylation endproduct receptor signaling 0.3586506786508064 0.2839669159856016 0.7764357346186677 1.0 0.8974472012610042 9 P05067 1 +Translation of sars cov 1 structural proteins 0.3835342709005439 0.2766467468730182 0.7820513661874764 1.0 0.9005080648340157 6 Q10472 1 +Phosphorylation of emi1 0.2898113668353265 0.273544277189427 0.7844348613658065 1.0 0.9005080648340157 3 P06493 1 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.3514408744617553 0.2734841849610508 0.7844810477089554 1.0 0.9005080648340157 5 P10644,P62873,Q9UBI6,P46940 4 +Regulation of mrna stability by proteins that bind au rich elements 0.253208371242473 0.2730940104781521 0.7847809507443746 1.0 0.9005080648340157 62 P60900,Q92945,P61289,Q14103,P49721,O75832,Q9Y3B2,P28074 8 +Deadenylation dependent mrna decay 0.2734709858008771 0.2713604051759271 0.7861138519642228 1.0 0.9009921493048964 40 Q969T7,P62310,Q9Y333 3 +Ub specific processing proteases 0.2518757164112593 0.2697103714175076 0.787383080915868 1.0 0.9009921493048964 71 P60900,Q9Y6K9,P45880,P61289,P49721,O75832,P28074,P21796 8 +Piwi interacting rna pirna biogenesis 0.3634253093237792 0.2669094034203206 0.7895389163413515 1.0 0.90195483550133 8 Q9Y2W6,P62875,P30876 3 +Autophagy 0.266896212954866 0.2669090586455776 0.7895391818054645 1.0 0.90195483550133 46 P49815,Q96E29,P08670,P68371,P63167,P50542,Q8WUX9,Q99570,Q9BUF5,P55072,Q15388,Q99497,P13473,Q9NT62,Q9NS69,P21796 16 +G2 m checkpoints 0.2440040755675347 0.2633198717170153 0.7923040445766032 1.0 0.9039541900540312 77 P60900,O96028,Q14566,Q9UQ84,P61289,P49721,O75832,Q9Y619,P28074 9 +Folding of actin by cct tric 0.3607551584264743 0.2580521514116813 0.7963666587876246 1.0 0.9067344861880672 8 P49368,P17987,Q99832 3 +Mitotic metaphase and anaphase 0.2333634604744695 0.2562383626410021 0.7977667880725079 1.0 0.9068398678357708 131 P60900,P63167,Q92621,Q5SRE5,P55735,P62826,P61289,P49721,O75832,P28074,Q92973,P20618,Q9P258,Q86XL3,P68371,O75531,P30260,Q8NFH4,Q9BUF5,Q8NBT2,Q8NFH3,Q9BTX1,Q14739 23 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3071826295893992 0.2554382457639332 0.7983846344316898 1.0 0.9068398678357708 17 P68371,Q9BUF5,P17987,P49368,Q99832,Q9UHV9,Q13885 7 +Protein methylation 0.3685780576731709 0.2553638364353227 0.7984420993772676 1.0 0.9068398678357708 7 O60678,P15880,P55072,P13639,P11142,O60870 6 +Glucose metabolism 0.249663224923571 0.2522007132582324 0.8008859267909632 1.0 0.9088631030249804 57 P55735,Q92621,Q8NFH4,P52789,Q8N1F7,P49792,Q5SRE5,Q8NFH3,Q9BTX1,Q9UBX3 10 +Sars cov 1 infection 0.3146459917597826 0.2490559084277926 0.8033175349132677 1.0 0.9099836420601054 13 Q8WUX9,Q10472,P55072,P17844,Q99570 5 +Cell cycle 0.2219298742540986 0.2452115239940638 0.8062926538805475 1.0 0.9099836420601054 286 P60900,O94927,O96028,P63167,P43034,Q92621,P11802,P42695,P50748,P30260,Q5SRE5,Q12888,O14965,Q9NRF9,Q9NYB0,P35250,P55735,Q15154,P04818,P61289,P62826,Q9BRT9,P49721,Q96CS2,P25788,P41440,O75832,P28074,P61163,Q01105,Q92973,Q08379,P20618,P63208,P62875,O43805,P33991,Q8TD19,Q14566,Q8WUX9,Q9NR33,O95684,Q8N1F7,P31751,P09884,Q9ULW0,Q9H6D7,Q9UH99,Q9P258,P04183,Q86XL3,Q86XI2,P07437,O75531,P68371,P30876,P28340,Q8NFH4,Q9UQ84,Q9BUF5,Q96CW5,Q8NBT2,Q8NFH3,P49792,Q07864,Q9BTX1,Q14739,Q9Y619,Q8WXH0,Q6IBW4 70 +Metabolism of amino acids and derivatives 0.2295125224947517 0.2430133013065093 0.8079950933212046 1.0 0.9099836420601054 188 P60900,P12277,P46777,P46782,P52788,Q9NR77,P50914,Q92947,P00390,Q13126,P62917,P62910,P61927,Q07020,P25398,P34896,P62753,P61289,O15382,P09622,P49721,P39023,O75832,P36578,P28074,P32929,P20618,P12532,Q9NVH6,P00367,Q02543,P49207,P63173,P11182,P18621,Q9UBX3,P46776,P23378,P08243,P61313,P54136,P62888,Q9Y619 43 +Deubiquitination 0.2404282768758666 0.2403503873121897 0.8100586361429425 1.0 0.910335568589994 89 P60900,Q9Y6K9,P45880,P61586,P61289,P49721,O75832,P28074,P21796 9 +Synthesis of ketone bodies 0.2802292669245108 0.2383200488446406 0.8116328725346769 1.0 0.910335568589994 3 P35610 1 +Sumoylation of dna damage response and repair proteins 0.2678625307592199 0.2370112042655111 0.8126480981331916 1.0 0.910335568589994 41 P55735,P09874,Q8NFH4,Q5SRE5,Q9BTX1,Q8IY18 6 +M phase 0.2290644353978662 0.2310392453711658 0.817284313299192 1.0 0.9123792333982844 187 P60900,O94927,P63167,Q92621,P42695,Q5SRE5,P55735,P62826,P61289,P49721,O75832,Q96CS2,P28074,Q92973,P20618,O43805,O95684,Q9H6D7,Q9P258,Q86XL3,Q86XI2,O75531,P68371,P30260,Q8NFH4,Q9BUF5,Q96CW5,Q8NBT2,Q8NFH3,Q9BTX1,Q14739,Q6IBW4 32 +Triglyceride metabolism 0.3678079835335957 0.2298164260701871 0.8182344201651619 1.0 0.9126972556639042 6 P62140,Q9HCL2 2 +Eph ephrin signaling 0.2763842634774096 0.2190097127997917 0.8266424817125086 1.0 0.9183429027607788 29 P35580,P61586,Q92542,P60660 4 +Hiv transcription elongation 0.2851089927460235 0.1971687710612575 0.8436954679721045 1.0 0.9312551746240768 20 P62875,O00267,P30876,Q15369,Q14241,Q09161 6 +Extension of telomeres 0.2707289097218082 0.1949010909851398 0.8454703800892531 1.0 0.9319079853802456 27 P35250,P28340,P09884,P41440 4 +Mapk3 erk1 activation 0.2947928604338658 0.1877736479239898 0.8510540942035159 1.0 0.9334686288675376 4 Q06124,P06493 2 +Mitochondrial calcium ion transport 0.2944328609504933 0.1817708492925902 0.8557625622722984 1.0 0.937604936610497 15 P45880,P21796 2 +Neddylation 0.2420341661912924 0.1772909793908517 0.8592798359625595 1.0 0.9386400755896748 68 P60900,Q8TBC4,P28072,Q9UBW8,Q9Y5A7,Q8NEZ5,P49720,P61289,P49721,O75832,P25788,P28074,Q9BT78,Q9BTE7,P20618,P63208,Q7L5N1,Q9NV06,Q15369,P61964 20 +Sensory perception 0.2695480189026127 0.1762605942307275 0.8600892185491942 1.0 0.9387767763321356 25 P50579,Q6NUM9 2 +Rac1 gtpase cycle 0.2573762076110612 0.1678966612489656 0.8666645767818368 1.0 0.94201681205593 41 Q9UQB8,Q14739 2 +Fgfr2 mutant receptor activation 0.3302493369419916 0.1663724097612544 0.8678638851593992 1.0 0.94201681205593 8 P62875,Q09161,P30876 3 +Signaling by fgfr2 iiia tm 0.3302493369419916 0.1663724097612544 0.8678638851593992 1.0 0.94201681205593 8 P62875,Q09161,P30876 3 +Abortive elongation of hiv 1 transcript in the absence of tat 0.2924873476059687 0.1617818335709725 0.8714776592830911 1.0 0.9446506955716928 12 P62875,Q09161,O00267,P30876 4 +Map3k8 tpl2 dependent mapk1 3 activation 0.3409579338438897 0.1593673405096845 0.8733794685223355 1.0 0.945758982488275 6 Q9Y6K9 1 +Influenza infection 0.2257784225232216 0.1564469801385717 0.875680708247474 1.0 0.9475031007220304 124 P46777,P46782,P50914,Q92621,Q5SRE5,P62910,P62917,Q07020,P55735,P61927,P25398,P62826,P62753,P39023,P36578,P09874,Q02543,P49207,P63173,Q8N1F7,P18621,O00410,P46776,P61313,P30876,Q8NFH4,P62888,P62266,Q8NFH3,Q9BTX1 30 +Rho gtpase cycle 0.2281806114282591 0.1520887019879026 0.8791169750530021 1.0 0.9498566275800792 153 Q9BZF9,Q9UQB8,P12277,P31948,P63167,Q8WUW1,O60879,Q96NT0,Q96HY6,P60953,Q8NBN3,Q96F07,Q13505,Q9UEY8,P08670,Q6XZF7,Q9NNW5,P61586,P06753,Q7L576,P84095,P30519,P41440,Q9BT78,O75976,Q9BZH6,P34897,P11182,Q9Y512,Q7Z6E9,Q86XL3,Q01968,P49257,P55072,Q14739,Q9BTT6,P67936 37 +Oncogenic mapk signaling 0.26221974833814 0.1450969278893026 0.8846343438112461 1.0 0.9521685952043324 28 Q13557,Q13555,Q96PU8 3 +Abc family proteins mediated transport 0.2436959787552385 0.1415146452235221 0.8874633912552476 1.0 0.9527384763710484 50 P60900,P61289,P49721,O75832,P08183,P28074 6 +Uch proteinases 0.2495721966966138 0.1390223801914818 0.8894324639413784 1.0 0.9534330575675676 45 P60900,P61289,P49721,O75832,P28074 5 +Formation of apoptosome 0.2749180842855133 0.1345716550408627 0.8929505537120193 1.0 0.9543006180307124 4 Q9BZF9,P28482 2 +Cytochrome c mediated apoptotic response 0.2749180842855133 0.1345716550408627 0.8929505537120193 1.0 0.9543006180307124 4 Q9BZF9,P28482 2 +Processing of capped intron containing pre mrna 0.2231241006902269 0.1335002086840114 0.8937977992423114 1.0 0.9543006180307124 185 P52272,Q9Y333,Q92621,Q14103,Q5SRE5,P31943,P62318,P55735,Q13243,Q9Y3B4,Q5KU26,P14866,P55769,P17844,Q09161,Q00839,Q15428,Q05048,O43390,Q13769,Q15366,P62314,P51991,O60828,Q9UHX1,Q6P2Q9,P62310,Q15365,Q8NFH4,Q9HCG8,Q08211,P62316,Q9BTX1,P84103 34 +Stimuli sensing channels 0.3286944996686491 0.131446740888886 0.8954219155145016 1.0 0.9545601150628564 6 Q12797,P30626,P51790,Q9H4A3,P27105 5 +Late endosomal microautophagy 0.3217118709619722 0.1284997616510262 0.8977534868358739 1.0 0.954819987549472 7 Q99497,Q8WUX9,P08670 3 +Cellular response to chemical stress 0.2349673513225255 0.1217772959906742 0.9030753952801174 1.0 0.9575111609925202 72 P60900,P20618,P00403,Q86X55,P61289,P09601,P49721,O75832,P30044,P30519,P28074,P00390 12 +Thromboxane signalling through tp receptor 0.2396557431314038 0.117133600623438 0.9067541835528188 1.0 0.9606692971694728 3 P62873,Q9UBI6 2 +Rnd1 gtpase cycle 0.2763349156592858 0.1112218080910759 0.9114404585651084 1.0 0.9641451882431216 12 P31948,Q9NNW5,O75976,P38159 4 +Post chaperonin tubulin folding pathway 0.2821338154449953 0.1024425763493084 0.9184053903750228 1.0 0.9679273934517018 11 P68371,Q9BUF5,Q99426,Q9BTW9,Q13885 5 +Rhoa gtpase cycle 0.24251607862658 0.1022101400338081 0.9185898793266702 1.0 0.9679273934517018 46 P49257,P63167,P61586,Q96NT0,Q14739,P30519,P41440 7 +Defective intrinsic pathway for apoptosis 0.271885417624315 0.1004924300169951 0.9199533923877784 1.0 0.9679273934517018 14 P05067 1 +Netrin 1 signaling 0.302055702917774 0.0984972003851764 0.9215374949202376 1.0 0.9688501479161428 8 Q00169,P19174,P63000,O94813,P15311,P60953,Q06124 7 +Thrombin signalling through proteinase activated receptors pars 0.2829833013095809 0.0946091957373972 0.9246252454606552 1.0 0.9713520955375337 5 P62873,P28482 2 +Metabolism of carbohydrates 0.2265615101651955 0.0908923377738769 0.9275781385624288 1.0 0.9729149630502212 94 P15586,P60174,Q8TB61,Q92621,Q5SRE5,Q9UHD1,P55735,Q7LGA3,P08236,P35573,Q8N1F7,Q8NCH0,Q9UBX3,O00462,Q8NFH4,P52789,P49792,P16278,Q8NFH3,Q9BTX1 20 +Glycogen breakdown glycogenolysis 0.2805564756541974 0.0900590423510448 0.9282402963795476 1.0 0.9729149630502212 5 P35573,P06737,P10253,P11216 4 +Antiviral mechanism by ifn stimulated genes 0.2324593421355357 0.0890087030837802 0.9290749935151634 1.0 0.9730464817578658 52 P55735,P21333,Q92621,Q13526,Q8NFH4,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1 10 +Dna damage recognition in gg ner 0.2667877226902356 0.0875895747793178 0.9302028884525788 1.0 0.9734846399366422 15 Q7L5N1 1 +Apc c cdc20 mediated degradation of cyclin b 0.300974913457278 0.0858871869774784 0.9315560971822248 1.0 0.9741577479679971 7 P06493,P14635,P30260 3 +Neuronal system 0.2358157601925453 0.0759823317842081 0.9394331547515496 1.0 0.9793821176500966 48 Q13557,O95197,P68371,Q13555,P41440,P10586 6 +Mapk6 mapk4 signaling 0.2356731709003954 0.0751716662789874 0.9400781275870786 1.0 0.9793821176500966 48 P60900,P61289,P49721,O75832,P28074 5 +Defects in biotin btn metabolism 0.2913490222074793 0.069005058894933 0.9449855926846932 1.0 0.9807263488376694 7 Q13085,P11498,Q9HCC0,Q96RQ3,P05166,P50747 6 +Formation of the early elongation complex 0.2588013774733061 0.0643141577793209 0.9487200805161956 1.0 0.983711303151164 14 P62875,Q09161,O00267,P30876 4 +Constitutive signaling by aberrant pi3k in cancer 0.2914197258731872 0.0635911894357054 0.949295747355788 1.0 0.983711303151164 6 Q06124,Q9NWH9,P84095 3 +Diseases of signal transduction by growth factor receptors and second messengers 0.2186102330332581 0.0482321107576455 0.96153125927548 1.0 0.9926417514868008 142 P60900,Q86WB0,Q6WCQ1,P35579,P28072,Q92542,P49815,P49720,Q13555,Q9NR09,P62753,Q14789,P06753,P61289,Q9UL46,P49721,O75832,P84095,P25788,P28074,Q09161,P48729,Q07866,P62487,Q53H12,P63208,P62875,P20618,O95684,Q96PU8,Q9NRY5,P31751,Q9P2E9,O15111,Q06124,O95429,Q9UBV2,P62140,Q13557,P30876,P55072,P49840,P49792,Q32MZ4,P67936 45 +Signaling by fgfr2 in disease 0.263312149351553 0.0460026675402269 0.9633081237726172 1.0 0.9937283803128052 10 P62875,Q09161,P30876 3 +Synthesis of pips at the plasma membrane 0.2614308167525502 0.0303126028553307 0.975817745567116 1.0 1.0 8 Q96T51,Q01968,Q9Y217 3 +Nervous system development 0.2104414818237202 0.028838750920227 0.9769931949573274 1.0 1.0 201 P60900,P46777,P46782,Q9NR77,P50914,P35579,Q92542,Q00535,P62917,P62910,P61927,P07737,P25398,Q07020,O15143,P61586,P62753,P61289,P39023,P35580,P49721,O75832,P36578,P28074,Q09161,P20618,O15020,P60660,P11047,Q02543,Q16850,P49207,P18621,P46776,P68371,P61313,Q9BUF5,P62888,Q15369 39 +Degradation of beta catenin by the destruction complex 0.2274235293206774 0.0263128562556692 0.9790078006531876 1.0 1.0 47 P60900,P61289,P49721,O75832,P28074 5 +Gap junction trafficking and regulation 0.2337433081883782 0.0158295014784666 0.987370412606508 1.0 1.0 12 P68371 1 +Condensation of prophase chromosomes 0.2309552042798671 0.011448888663432 0.9908653080556138 1.0 1.0 12 P42695,Q01105,Q86XI2,Q6IBW4 4 +Transport of mature transcript to cytoplasm 0.2180805171689227 0.0074292783210924 0.9940723480583876 1.0 1.0 66 P55735,Q13243,Q13769,Q92621,Q8NFH4,Q01130,Q8NFH3,Q8N1F7,P49792,Q5SRE5,Q9BTX1,Q92620,P84103,Q09161 14 +Processing of capped intronless pre mrna 0.2327438280808494 0.006884466895857 0.9945070335451388 1.0 1.0 19 Q5KU26,Q09161,P62318 3 +Hiv life cycle 0.218430975405645 0.0050821802805707 0.9959450242746182 1.0 1.0 73 O00267,Q92621,Q5SRE5,P29083,P55735,P62826,Q14241,Q09161,P62875,Q8WUX9,Q92804,Q8N1F7,O75531,P30876,Q8NFH4,Q15369,Q8NFH3,P49792,Q9BTX1 19 +Dna repair 0.2164571318496922 0.0034239939174573 0.9972680534550816 1.0 1.0 97 O96028,Q9H1I8,Q12888,Q9NRF9,Q9NYB0,Q9UBW8,Q6P6C2,P35250,P41440,Q9BT78,P27695,P09874,Q9NR33,Q8N3C0,Q7L5N1,P78527,P28340,P30876,Q9UQ84,P55072,Q07864,Q93009,Q9UIG0 23 +Mitotic prometaphase 0.2140487087941913 0.0018865067070308 0.9984947863174284 1.0 1.0 89 O94927,P63167,P43034,P50748,P55735,Q15154,Q96CS2,P61163,O43805,O95684,Q9H6D7,Q9P258,P68371,P07437,Q8NFH4,Q9BUF5,Q96CW5,Q8NBT2,Q8NFH3,P49792 20 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.2311761183164872 0.0016672634689868 0.9986697168356178 1.0 1.0 7 O43684,Q9UJX3,P30260 3 +Apc cdc20 mediated degradation of nek2a 0.2311761183164872 0.0016672634689868 0.9986697168356178 1.0 1.0 7 O43684,Q9UJX3,P30260 3 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bc6e778262032b22ed003a24e1febbb292439ca3 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the phototransduction cascade", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling by cbl mutants", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose catabolism", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Olfactory signaling pathway", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr regulates axonogenesis", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase 2 plateau phase", "Phase 3 rapid repolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Ptk6 regulates rtks and their effectors akt1 and dok1", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory perception of taste", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sodium proton exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Terminal pathway of complement", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride biosynthesis", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "APLP2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC8", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3B", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATRX", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRK1", "BSG", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CAD", "CADM1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC22", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDS2", "CENPH", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLINT1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CLU", "CMAS", "CMBL", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COG3", "COG4", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJB11", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPH5", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFTUD2", "EHD1", "EHMT2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM3C", "FAM49B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FIS1", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FOXK2", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKG", "ILF2", "ILK", "IMMT", "IMP4", "IMPDH2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO5", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRS4", "ISCU", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRRC1", "LRRC8A", "LRRC8C", "LRRFIP1", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LYPLA1", "MAGED2", "MAGT1", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MAPRE1", "MARC1", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "METAP1", "METAP2", "MFAP1", "MFN1", "MFN2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MIPEP", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1C", "MYO5A", "MYO6", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCKAP1", "NCKIPSD", "NCL", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEK9", "NELFA", "NELFB", "NELFCD", "NFS1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIT2", "NLN", "NLRX1", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT16", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN1", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PMVK", "PNO1", "PNP", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIE", "PPIH", "PPIL1", "PPIL4", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUS1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RALGAPB", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIPK1", "RNASET2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SATB2", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX2", "SNX3", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX18", "STX3", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE1", "SYNE2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM87A", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMX3", "TNPO1", "TNRC6B", "TOLLIP", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRMT10C", "TRMT11", "TRMT112", "TRMT6", "TRMU", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TSTA3", "TTC26", "TTC37", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXNDC5", "TXNL1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UACA", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBR1", "UBR2", "UBR4", "UBTF", "UBXN1", "UCHL5", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASF2", "WBP11", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR34", "WDR36", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WNK1", "WRAP53", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF638", "ZW10", "ZWILCH"], "leading_proteins": ["ABCB1", "ABHD10", "ACACA", "ACACB", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACTR1A", "ADA", "ADD3", "ADK", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIP", "AKAP9", "AKT2", "ALDH1B1", "ALG11", "ALG12", "ALKBH5", "ANAPC7", "ANKLE2", "ANP32A", "AP1M1", "APEX1", "APLP2", "APOO", "APP", "ARPC1B", "ARSA", "ASCC2", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATG3", "ATP13A1", "ATP1A1", "ATP2B1", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "AURKA", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1B", "BCAT2", "BIRC6", "BLMH", "BRK1", "BUB3", "CALU", "CAMK2D", "CAMK2G", "CAP1", "CAPN5", "CARM1", "CCDC115", "CCNB1", "CCT3", "CCT7", "CDC27", "CDC42", "CDC45", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CHKA", "CHMP7", "CHORDC1", "CHST14", "CHUK", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CMBL", "COASY", "COLEC12", "COPS4", "COPS6", "COPS7A", "COX2", "CPD", "CPNE3", "CPOX", "CROT", "CSNK1A1", "CSTF1", "CTH", "CTNNB1", "CTSA", "CTSC", "CWC22", "CYB5B", "CYB5R3", "CYFIP1", "CYFIP2", "CYP51A1", "DBT", "DCAF13", "DCUN1D5", "DDRGK1", "DDX5", "DHCR24", "DHCR7", "DHX36", "DHX38", "DHX9", "DIAPH2", "DLD", "DNAJC7", "DNMBP", "DNMT1", "DOHH", "DYNC2H1", "DYNLL1", "EBP", "ECE1", "EED", "EEF2", "EHMT2", "ELOA", "ELOC", "ENDOD1", "EPHX1", "ERAP1", "EXO1", "EXOC1", "EXOC2", "EXOC6", "EXOC8", "EXOSC1", "EZR", "FADS2", "FAM114A2", "FAR1", "FASN", "FBXO22", "FECH", "FGFR1OP", "FLNA", "FN3KRP", "GAA", "GAK", "GALNT1", "GCDH", "GGCX", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLUD1", "GNB1", "GNG12", "GNS", "GOLGA2", "GOLGB1", "GPAM", "GSK3A", "GSR", "GSTO1", "GTF2E1", "GUSB", "HADHA", "HAGH", "HAUS1", "HAUS4", "HAUS5", "HEBP1", "HK2", "HLA-A", "HLA-C", "HLCS", "HMGB1", "HMMR", "HMOX1", "HMOX2", "HNRNPA3", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HS2ST1", "HSD17B12", "HSPA8", "ICMT", "IGF2R", "IKBKG", "IPO5", "IQGAP1", "IQGAP2", "ITGB1", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIN", "KLC1", "KMT2A", "KNTC1", "LAMC1", 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"Average number of proteins per term", + "value": 10.149078726968174 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..41d693b0713b09da0fa224a59e689051987cbc72 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cf67b5aeb5c49327c1ef1ba788440586f926225a --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,235 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Inclusion body myositis 0.9487094639311724 4.024052576436688 5.720513742080158e-05 0.0335758320589648 0.0010044549129476 2 P05067 1 +Nodlike receptor nlr signaling pathway 0.887160820648579 3.737747647862917 0.0001856761687435 0.1049350244767057 0.0020821534421547 2 Q9Y6K9 1 +Canonical nfkb pathway 0.887160820648579 3.737747647862917 0.0001856761687435 0.1049350244767057 0.0020821534421547 2 Q9Y6K9 1 +Altered glycosylation of muc1 in tumor microenvironment 0.887160820648579 3.737747647862917 0.0001856761687435 0.1049350244767057 0.0020821534421547 2 Q9Y6K9 1 +Fibrin complement receptor 3 signaling pathway 0.8874544852697661 3.3365394016181504 0.0008482840348777 0.3974836558311382 0.0077911625972622 3 P61586,Q9Y6K9 2 +Supression of hmgb1 mediated inflammation by thbd 0.878517047335321 3.2957637552959724 0.000981545177098 0.4436013488521045 0.008744766368395 3 Q9Y6K9,O15111 2 +Arachidonate epoxygenase epoxide hydrolase 0.7954996690933176 3.291188196353164 0.0009976514590452 0.4489309821219403 0.008744766368395 2 P20674 1 +Neuroinflammation 0.8403459181288175 3.119202145053095 0.0018134150326183 0.6616219685745179 0.0144347836596419 3 P00403 1 +Monoamine transport 0.7571144937127787 3.0963615891297898 0.0019591130023415 0.6898619136631274 0.0153893481894459 2 P49815 1 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.9027887357165968 3.0414162837326906 0.002354680344442 0.7552215607949317 0.0177942299447079 4 P07099 1 +Nephrogenesis 0.7392455327597653 3.0039890085183796 0.0026646495138837 0.7966687769492684 0.0191041353828244 2 O95747 1 +Glycerolipids and glycerophospholipids 0.7931165862620349 2.895136555110152 0.0037899362311084 0.8963660534497332 0.02470534467736 3 Q9HCL2 1 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.6843704249836429 2.888806033063102 0.0038670753047318 0.9010478964508292 0.024824128569085 21 P48449,P49327,O95864,Q16850,Q9BWD1,Q15392,Q15125,Q15800,Q14739 9 +Sting pathway in kawasakilike disease and covid19 0.7892458455725764 2.8764893243636203 0.0040212579766381 0.9097824127466244 0.0252780664061027 3 Q9Y6K9 1 +Apoptosis modulation by hsp70 0.7657347338942757 2.762279357825892 0.0057399343052444 0.9678265342090484 0.0337940418826325 3 O95831 1 +Striated muscle contraction pathway 0.9075451955893268 2.7612103347346095 0.005758757543361 0.9681881260673134 0.0337940418826325 5 P09493,P08670,P67936 3 +Familial hyperlipidemia type 5 0.6929185969556635 2.7593388818288216 0.0057918439333706 0.9688139057094568 0.0337940418826325 2 Q9UBV2 1 +Familial hyperlipidemia type 1 0.6929185969556635 2.7593388818288216 0.0057918439333706 0.9688139057094568 0.0337940418826325 2 Q9UBV2 1 +Nad metabolism 0.7634049132366523 2.750872583737693 0.0059436757080006 0.9715316280190092 0.0337940418826325 3 P43490 1 +Nad biosynthetic pathways 0.7634049132366523 2.750872583737693 0.0059436757080006 0.9715316280190092 0.0337940418826325 3 P43490 1 +Mapk and nfkb signaling pathways inhibited by yersinia yopj 0.7555398417283947 2.712245376642045 0.0066829102195504 0.9817408415170362 0.0366027284501984 3 Q9Y6K9 1 +Mitochondrial complex ii assembly 0.6793514228987481 2.686241159431395 0.007226091242269 0.9868276923911884 0.0381412598246366 2 P31040 1 +Ovarian infertility 0.7411589341351386 2.6411359797141976 0.0082628548250074 0.9929407559934904 0.0414531456347011 3 Q8WXH0 1 +Neovascularisation processes 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9964975211344388 0.0461278059360294 2 P28482 1 +Mitochondrial fatty acid synthesis pathway 0.7245945051307516 2.5584515466783513 0.0105139470944402 0.9981820697524846 0.0506195678659742 3 Q8IVS2,Q53GQ0 2 +Nad metabolism sirtuins and aging 0.7098682397030625 2.4842369913169913 0.0129829372825085 0.9995909067731876 0.0582767936665985 3 P43490 1 +Angiotensin ii receptor type 1 pathway 0.7077126779212153 2.4733177974035634 0.0133865044544894 0.9996795281529356 0.0596398743233595 3 Q06124,P63244 2 +Eicosanoid metabolism via lipooxygenases lox 0.8926372573905879 2.423225609996784 0.0153833696349905 0.9999043910410484 0.0670355596502872 6 O15254,Q8N8N7,Q14914 3 +Vitamin d metabolism 0.6951340615690135 2.4093134385295856 0.015982565085655 0.9999335235770814 0.0691419663488122 3 Q9UBM7,P38435 2 +Familial hyperlipidemia type 4 0.6931479642502373 2.399162751303539 0.0164326091284188 0.9999494104663876 0.069452536981284 3 P49327,Q9UBV2 2 +Triacylglyceride synthesis 0.7572847682119126 2.383565217149803 0.0171458461110169 0.999967192037568 0.0710838203352579 4 O00116,Q99943,Q9HCL2 3 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.8185615017529635 2.379743821125337 0.0173246775091793 0.9999705693528744 0.0713298791240003 5 P09601,Q9Y6K9 2 +Metabolism of spingolipids in er and golgi apparatus 0.6876874739226145 2.371191934255653 0.0177308208690682 0.999977005771954 0.0720088439376447 3 Q10472 1 +Onecarbon metabolism and related pathways 0.6816277075442696 2.3662516829051774 0.0179692240606317 0.9999801077578072 0.0720588384088134 14 O43865,P34896,P04818,O15382,P35790,P00390,P32929 7 +Eicosanoid synthesis 0.6105228325612251 2.3049355051028497 0.021170185757892 0.9999971673567354 0.0836993436917985 2 Q9H7Z7 1 +Nocgmppkg mediated neuroprotection 0.8316763738994788 2.2811930266531144 0.0225370272200973 0.9999987700484844 0.0879385964078307 7 P30536 1 +Eicosanoid metabolism via cyclooxygenases cox 0.8560440418544618 2.2725870304549733 0.0230510779362871 0.9999991015389562 0.0891858868288886 6 O15254,Q8N8N7,Q14914 3 +Hypothesized pathways in pathogenesis of cardiovascular disease 0.6630254882489258 2.2437131894526563 0.024850860939529 0.9999997011784774 0.0934113429494498 3 P21333,P28482 2 +Cannabinoid receptor signaling 0.6630254882489217 2.243713189452636 0.0248508609395303 0.9999997011784774 0.0934113429494498 3 P10644,P28482 2 +Regulation of wnt bcatenin signaling by small molecule compounds 0.6623634558093323 2.2402651978543764 0.0250737111992371 0.9999997392925676 0.0934113429494498 3 Q07954,P48729 2 +Heart development 0.6623634558093303 2.2402651978543693 0.0250737111992376 0.9999997392925676 0.0934113429494498 3 Q06124,P28482 2 +Dna mismatch repair 0.6167444768202145 2.2257003327541542 0.0260342604653645 0.99999985526381 0.0947710579135524 18 P28340,Q9NR33,Q9UQ84,P41440,Q9NRF9,P35250 6 +Hair follicle development cytodifferentiation part 3 of 3 0.5946393117141043 2.2144260985282416 0.0267994812178877 0.9999999094700948 0.0963812667896325 2 P35222 1 +Joubert syndrome 0.6447295293298397 2.2101561353409855 0.0270943280763418 0.9999999244509574 0.0968581668357848 15 P09874,P21333,O43924,Q9Y4I1,P61586,Q10713 6 +Influence of laminopathies on wnt signaling 0.758211447431147 2.1977572944663715 0.0279664062114892 0.9999999557695964 0.0993806220729708 9 O60725 1 +Hostpathogen interaction of human coronaviruses autophagy 0.7158121881608396 2.1861582823157972 0.0288040271990515 0.999999973563552 0.1008759863638767 4 Q99570 1 +Mammary gland development pathway pregnancy and lactation stage 3 of 4 0.774629726405501 2.184927991730531 0.028894126747442 0.9999999749879837 0.1008759863638767 5 P06753 1 +Microglia pathogen phagocytosis pathway 0.6501158556769182 2.176233949018625 0.0295377716067841 0.9999999831637196 0.1025235444723845 3 O15143,O00443 2 +Sterol regulatory elementbinding proteins srebp signaling 0.53845129304839 2.1383237334377334 0.0324904776100312 0.9999999972698712 0.1102091768931172 25 Q8WTV0,P55735,P48449 3 +Progeriaassociated lipodystrophy 0.7424759288675618 2.1229069559281752 0.0337616494591024 0.9999999987545976 0.1137834640261338 9 P09874,O75531,P46063,O60725,O75844 5 +Base excision repair 0.6553143150960876 2.1209573951834537 0.0339253879340901 0.9999999988744376 0.1137834640261338 12 P27695,P09874,P28340,Q9NR33,P09429,Q9NRF9 6 +Oxidation by cytochrome p450 0.7574596490210304 2.107625641399219 0.0350633838266587 0.999999999443102 0.1156510505221838 5 Q16850 1 +Vitamin a and carotenoid metabolism 0.7498092684755312 2.0729751361474924 0.0381745935826027 0.999999999919005 0.1245367889006221 5 Q8WTV0 1 +Ferroptosis 0.5380435338117266 2.020688033238859 0.0433120693830664 0.9999999999966898 0.1397692184956251 23 Q6P1A2,P45880,Q15365,P09601,Q15043,P32929 6 +Mirna biogenesis 0.6176762661370376 2.0044314604241222 0.0450238620706673 0.9999999999988636 0.1445120734203677 3 Q9HAV4,P62826 2 +Familial partial lipodystrophy fpld 0.766302233905401 1.9948431830712263 0.0460599859046544 0.9999999999994056 0.1462649552397803 7 O60725,O75844,O75531 3 +Insulin signaling in adipocytes diabetic condition 0.6751442378834783 1.9883073334675705 0.046777710230687 0.9999999999996207 0.1467678990301716 4 P31751 1 +Insulin signaling in adipocytes normal condition 0.6751442378834783 1.9883073334675705 0.046777710230687 0.9999999999996207 0.1467678990301716 4 P31751 1 +7oxoc and 7betahc pathways 0.71369318073918 1.9844855591032509 0.0472017363715124 0.9999999999997092 0.1467678990301716 9 P61916,Q9UBM7,Q15125,O15118 4 +Relationship between inflammation cox2 and egfr 0.6632450331125745 1.9296408512374792 0.053651353452838 0.999999999999995 0.1651023608832179 4 Q9H7Z7,P31751,P28482 3 +Foxa2 pathway 0.6014564713670899 1.9173586994248992 0.0551923773449891 0.999999999999998 0.1681114758926455 3 P49327,Q13085 2 +Methionine metabolism leading to sulfur amino acids and related disorders 0.7151055660409285 1.9142254314670135 0.055591357602402 0.9999999999999986 0.1684672106022032 5 P55263 1 +Cholesterol biosynthesis pathway 0.6389443756267766 1.874813551624467 0.0608183781932023 1.0 0.181542858906709 11 P48449,Q16850 2 +Cholesterol biosynthesis with skeletal dysplasias 0.7572049369576948 1.8529817660569987 0.0638849721952716 1.0 0.1897479024904337 6 Q16850,Q15392,Q14739 3 +Proteoglycan biosynthesis 0.6468823845171506 1.8484177113685825 0.0645419384695284 1.0 0.1907501844866758 4 Q8TB61 1 +Hair follicle development organogenesis part 2 of 3 0.5868917576961246 1.8385325542692696 0.0659839693864401 1.0 0.1940513779492845 3 Q9BZE4,P35222 2 +Wntbetacatenin signaling pathway in leukemia 0.5849056603773544 1.8277381514031257 0.0675888594252338 1.0 0.1977968092003167 3 P48729,P35222 2 +Mirnas involvement in the immune response in sepsis 0.5844166075581861 1.8250785185402931 0.067989181337263 1.0 0.1979977622358343 3 Q9Y6K9 1 +Rala downstream regulated genes 0.7348225386089859 1.755534101941418 0.079167992838796 1.0 0.2229400553054775 6 Q8IYI6,P16989 2 +Mthfr deficiency 0.707091777687166 1.7283044630353812 0.0839336533412675 1.0 0.233062283929008 7 P35790,P26358 2 +Reninangiotensinaldosterone system raas 0.5656518896164334 1.7225540473112328 0.0849692010419507 1.0 0.2348454306576137 3 Q13555 1 +Oxidative stress response 0.6195695314873914 1.7114927384940166 0.086990190536333 1.0 0.239323243088437 4 P09601 1 +Neurodegeneration with brain iron accumulation nbia subtypes pathway 0.6021860605731817 1.675457816452505 0.0938444409925369 1.0 0.2523654561826332 11 P49815,Q99570,O15269,Q13057 4 +Aryl hydrocarbon receptor pathway wp2873 0.6031049608794152 1.6282043936724933 0.1034815534766073 1.0 0.2757968188639937 4 Q15185 1 +Spinal cord injury 0.5159277415165131 1.577981326286082 0.1145698998530599 1.0 0.3003353042075292 18 P61586,P14174,P08670 3 +T cell receptor and costimulatory signaling 0.5930699811952849 1.5771928111390416 0.1147511666246567 1.0 0.3003353042075292 4 P49840,P48729 2 +Resistin as a regulator of inflammation 0.6938661031479618 1.5752272716177729 0.1152039944112632 1.0 0.3003353042075292 6 Q9Y6K9,P31751 2 +Selenium micronutrient network 0.6064767523887556 1.5684983013914682 0.1167648860664614 1.0 0.301768991262673 10 Q8WTV0,P30044,P32929 3 +Nitric oxide metabolism in cystic fibrosis 0.6318906450617713 1.5241204112974576 0.1274786347483458 1.0 0.3221180568797035 5 Q86X55 1 +Nephrotic syndrome 0.5501460850360027 1.5231321199400707 0.1277256543649456 1.0 0.3221180568797035 12 Q14108 1 +Follicle stimulating hormone fsh signaling pathway 0.6290573979480035 1.5106429112691129 0.1308794547590994 1.0 0.3269248305070392 5 P49815,P28482,P62753 3 +Atm signaling in development and disease 0.4728177323493918 1.5023233644100942 0.1330136174243281 1.0 0.3289864036863602 22 P49815,Q9Y6K9,P78527,Q14739 4 +Ebola virus infection in host 0.4164983883465702 1.4716747016744194 0.1411087423297574 1.0 0.3438445680443477 36 P10321,O75569,P61586,P41440,P61916,O15118 6 +Metapathway biotransformation phase i and ii 0.4736737769912332 1.468752486237718 0.1418999356783126 1.0 0.3443669170729781 21 O14880,O43488,Q7LGA3,Q16850,Q86UY6,P07099,Q8NCH0,P00390 8 +Dna repair pathways full network 0.3985467182358189 1.4583698339732147 0.1447386308614637 1.0 0.3498338567785177 44 P27695,P09874,Q9NR33,Q9UQ84,P78527,P09429,P41440,Q9NRF9,P35250 9 +Tolllike receptor signaling related to myd88 0.5692825159616168 1.4556237835506152 0.1454966495937673 1.0 0.3499072979440462 4 Q9Y6K9 1 +Folatealcohol and cancer pathway hypotheses 0.4665784248841906 1.4527184100515924 0.1463019533008207 1.0 0.3499072979440462 2 P11766 1 +Pregnane x receptor pathway 0.5673264897160468 1.4455920980929695 0.1482916442875201 1.0 0.3499072979440462 4 P08183 1 +Omega3 omega6 fatty acid synthesis 0.6645543903163934 1.444871925113443 0.1484938635000841 1.0 0.3499072979440462 6 O15254,Q15067 2 +Dna replication 0.4373003116482603 1.438239892915396 0.1503659997836877 1.0 0.3506582104330529 28 P28340,O43913,P33991,P12004,Q14566,P49736,Q07864,P09884,P41440,Q9Y619,P35250 11 +Heme biosynthesis 0.612677867843148 1.432540717073582 0.1519891340198453 1.0 0.3514374468787428 5 P36551,P22830 2 +Transsulfuration pathway 0.6197022919429866 1.4165739785095306 0.1566075208886814 1.0 0.355493117758718 8 P32929,P26358 2 +Osteoblast differentiation and related diseases 0.6140603778229117 1.389283776934131 0.1647464750762366 1.0 0.3697505474455386 8 Q05655,O00443,P78527,P28482,Q99570,P27361 6 +Extracellular vesiclemediated signaling in recipient cells 0.5042433321187133 1.3815723340795023 0.1671030535968269 1.0 0.3722407574526332 3 Q9NWH9 1 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.5117562523820499 1.3670998473436635 0.1715940111354872 1.0 0.3806682218686415 14 O60725,O75844 2 +Envelope proteins and their potential roles in edmd physiopathology 0.475248415760236 1.360339010164911 0.1737226689987114 1.0 0.3812957110008483 19 P61586,O75531 2 +Interactome of polycomb repressive complex 2 prc2 0.5969603648456736 1.3573474803971808 0.1746708274622468 1.0 0.3819724688460123 5 Q9NYF8,O75530 2 +Sulfation biotransformation reaction 0.5483443708609148 1.3480267881877344 0.1776497667892094 1.0 0.3856614937205745 4 P00390,P11413,O95340 3 +Target of rapamycin tor signaling 0.5926434446613795 1.336662844053148 0.1813327154851922 1.0 0.3892773256143036 5 P49815 1 +Nucleotidebinding oligomerization domain nod pathway 0.6216243549267358 1.3341031494830682 0.1821700538174435 1.0 0.3892773256143036 7 Q9Y6K9,Q7L5N1 2 +Alpha 6 beta 4 signaling pathway 0.5825569564430984 1.332866462676784 0.182575630103861 1.0 0.3892773256143036 9 Q05655,P11047,P61586,P28482,Q06124,P27361 6 +Pyrimidine metabolism 0.394418362582037 1.2992978939933053 0.1938417168401529 1.0 0.4089169786345276 38 P04183,P62875,P17812,P32321,P28340,P30876,Q9NR33,P04818,Q07864,P09884,P27708,Q9H9Y6,Q9NRF9,Q9H773 14 +Hijack of ubiquitination by sarscov2 0.6300468428396235 1.2904752319415198 0.196885706006944 1.0 0.4138759383314984 6 Q15369,Q9C0D3 2 +Regulation of apoptosis by parathyroid hormonerelated protein 0.4848641424834211 1.272814710850983 0.2030837997468197 1.0 0.4210180891949846 3 P49840 1 +Phosphoinositides metabolism 0.6244596644200945 1.2654240252264972 0.2057193673289812 1.0 0.4249635373543314 6 Q99570,Q01968,Q9Y217 3 +Wnt signaling pathway 0.5260718062783997 1.2547082175196882 0.20958470154758 1.0 0.4314554028410526 11 P61586 1 +Nucleotide excision repair 0.4430427226139018 1.2491559835155797 0.2116080276729042 1.0 0.4341236856382262 21 Q9NRF9,P35250,Q9NR33,P41440 4 +15q112 copy number variation syndrome 0.5230336621229941 1.217563423208373 0.2233899211270551 1.0 0.4520806200435658 4 Q7L576 1 +Allograft rejection 0.5563149930170147 1.1999738669603066 0.2301494899463225 1.0 0.4571110499878977 9 P04439,P10321,P08670,P08183 4 +Transsulfuration and onecarbon metabolism 0.4490433239509354 1.1816154823012752 0.2373583075087588 1.0 0.4692149323931425 19 O43865,P26358,P34896,P04818,P32929 5 +Interactions between loxl4 and oxidative stress pathway 0.4677916174862134 1.1768864884359145 0.2392408157048682 1.0 0.4706134477713043 3 Q8TAG9 1 +Small cell lung cancer 0.5090225817393934 1.1598453738964605 0.2461117666498937 1.0 0.4791955835959321 11 Q9Y6K9,P11047,P11802,P31751,O15111 5 +Oxysterols derived from cholesterol 0.5820315554816183 1.1496657617798614 0.2502815612761049 1.0 0.4792840774489459 7 Q9UBM7,Q15125 2 +Angiogenesis 0.4172733289212562 1.1491839905193342 0.2504801208778411 1.0 0.4792840774489459 2 P28482 1 +Synaptic signaling pathways associated with autism spectrum disorder 0.5947249103209282 1.1321152070197844 0.2575860023493925 1.0 0.4897415394986858 6 P49815 1 +Circadian rhythm genes 0.3742531122436727 1.1275399625370992 0.259514254245192 1.0 0.4918413009027925 39 Q03164,P63208,P49327,P23246,Q15233,P00813,P11802,P04818,P78527,Q14103,Q08211,Q9NRV9,P17844,P43490,P62140,Q00839 16 +Constitutive androstane receptor pathway 0.5408908014726121 1.0884740113559177 0.2763859034952589 1.0 0.5172488538767072 5 P08183 1 +Disruption of postsynaptic signaling by cnv 0.5317500419539891 1.0757241738582657 0.2820506327927903 1.0 0.5262007118040495 9 Q7L576,Q13555 2 +Vitamin b12 metabolism 0.5655949301830097 1.073238530392502 0.2831641071351041 1.0 0.526632311400801 7 Q8WTV0 1 +Estrogen signaling pathway 0.5366085774354747 1.0679944521002882 0.2855230143679916 1.0 0.5293703092474876 5 Q9Y6K9,P62873,O15111 3 +Glycerophospholipid biosynthetic pathway 0.5629643315038838 1.0610297959351431 0.2886763604123314 1.0 0.5313230566214173 7 O00116,Q9HCL2 2 +Mfap5mediated ovarian cancer cell motility and invasiveness 0.4468923264926595 1.0596805615049638 0.2892899490461325 1.0 0.5313230566214173 3 P28482 1 +Nongenomic actions of 125 dihydroxyvitamin d3 0.5411898147649078 1.0361816854677388 0.3001173893149125 1.0 0.5429396406697053 8 Q13557,Q13555 2 +Vitamin d receptor pathway 0.4658930624456358 1.0306005560059452 0.3027281752477166 1.0 0.5443636163339965 12 P09493 1 +Chromosomal and microsatellite instability in colorectal cancer 0.4556061517586067 1.0252945482130082 0.305224227421665 1.0 0.5444919192361753 14 Q96KP1,P61586 2 +Autophagy 0.5264037571798035 1.0192856509876955 0.3080673741253215 1.0 0.5444919192361753 5 Q99570 1 +Primary focal segmental glomerulosclerosis fsgs 0.4316948027757344 1.018802796447162 0.308296597859734 1.0 0.5444919192361753 18 P08670,P11047,Q14108,P46013,P35579 5 +Tryptophan metabolism 0.44902875865925 1.0168403827176122 0.3092293679477844 1.0 0.5444919192361753 15 Q16836,Q15392,P40939,Q92947,O94788,Q99873 6 +Corticotropinreleasing hormone signaling pathway 0.4387225843714576 0.9866936041468488 0.3237928664636773 1.0 0.5615964464880564 16 P61586,P42892 2 +Immune response to tuberculosis 0.3898080741231083 0.9806139174427276 0.3267831685143003 1.0 0.5615964464880564 2 O60244 1 +Sars coronavirus and innate immunity 0.3898080741231079 0.9806139174427244 0.3267831685143019 1.0 0.5615964464880564 2 Q7Z434 1 +Folate metabolism 0.4438606085043259 0.954338580090366 0.3399122852608327 1.0 0.5797932408591918 14 Q8WTV0,P34896,P32929,P41440 4 +Proteasome degradation 0.3516681998415478 0.9464979281587568 0.3438946785049834 1.0 0.5849148805341171 41 P60900,P20618,P10321,P61289,P49721,O75832,P28074 7 +Hostpathogen interaction of human coronaviruses interferon induction 0.550375721957967 0.9345603219466468 0.3500149352513904 1.0 0.5936332850712501 6 Q9Y6K9 1 +Hif1a and pparg regulation of glycolysis 0.421990239049181 0.9211066111632596 0.3569947689419561 1.0 0.6024906623462042 3 P60174 1 +Omega9 fatty acid synthesis 0.5044185208845461 0.9150024322601036 0.3601903532516259 1.0 0.6057285658907626 5 P49327,O95864 2 +Cardiac hypertrophic response 0.4439559052019431 0.9035053126779726 0.3662577699154461 1.0 0.6107706386578808 12 Q9Y6K9,P31751,O15111 3 +Genes related to primary cilium development based on crispr 0.4609936073506975 0.8945931821231555 0.3710045977501577 1.0 0.6152492912690116 11 A0AVF1,Q10713,P63167 3 +Male infertility 0.3846216002904697 0.8898858034669461 0.3735272075673386 1.0 0.6177167393842137 23 P09874,Q8IWV8,Q15165,P08183,P41440 5 +Wnt signaling 0.4366308570305315 0.8846495910465203 0.376345651223001 1.0 0.6201831828182331 13 Q13555 1 +Sphingolipid metabolism in senescence 0.4746565058167332 0.8734356061095445 0.3824256905599408 1.0 0.6272201573194633 10 P11802,Q06136,P16278,O15269,P28482,P04062 6 +Bile acids synthesis and enterohepatic circulation 0.4116940887997687 0.8644207967901473 0.3873567724445443 1.0 0.633567104518885 3 P28482 1 +Leptin and adiponectin 0.3692918596955758 0.856294081274127 0.3918351342780228 1.0 0.6384978599540274 2 Q13085 1 +Ebsteinbarr virus lmp1 signaling 0.4880147145407543 0.8380444458714433 0.4020057418622844 1.0 0.6439499569133266 5 Q9Y6K9 1 +Dna irdouble strand breaks and cellular response via atm 0.3846890459360026 0.8332003209134602 0.4047317616450891 1.0 0.6439499569133266 21 P09874,Q9UQ84,P78527 3 +Tcell activation sarscov2 0.4309344753422335 0.82894613135244 0.407134889921108 1.0 0.6439499569133266 12 P49815,Q9Y6K9 2 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.418148378240075 0.8276962310809781 0.4078425541169928 1.0 0.6439499569133266 15 P05067,P16989 2 +Tlr4 signaling and tolerance 0.4833448533345072 0.816310873276375 0.4143223570774363 1.0 0.6509222294084986 5 Q9Y6K9 1 +Fatty acid betaoxidation 0.3929031951760035 0.8027401834543165 0.4221249220236438 1.0 0.6597083205448045 19 P09622,O43772 2 +Alzheimers disease 0.2791253694274343 0.7910657360582924 0.4289056324657001 1.0 0.6685552547833499 81 P60900,P20618,O95197,P68371,P45880,Q92542,P49721,P31751,O15111,P28074,P05067,Q00535,P21796 13 +Nucleotide excision repair in xeroderma pigmentosum 0.345459632469478 0.7730223015085977 0.4395091823159422 1.0 0.6762551078417978 31 P09874,P28340,Q9NR33,Q07864,P41440,Q9NRF9,P35250 7 +Alzheimers disease and mirna effects 0.278039546814683 0.7667876055352291 0.4432078067860301 1.0 0.6784488734647691 82 P60900,P20618,O95197,P68371,P45880,Q92542,P49721,P31751,O15111,P28074,P05067,Q00535,P21796 13 +Kallmann syndrome 0.4330973238250132 0.7601407183529189 0.4471704757077765 1.0 0.6796570740950281 4 Q06124,P28482 2 +Dna irdamage and cellular response via atr 0.3388703106785065 0.7579478211317919 0.4484822203803467 1.0 0.6796570740950281 32 P09874,Q9Y6K9,Q9UQ84,P78527 4 +Id signaling pathway 0.3527465254798211 0.7578331073433577 0.4485508998215093 1.0 0.6796570740950281 2 P24941 1 +Vitamin d in inflammatory diseases 0.4682532701932261 0.7467263520073599 0.4552287595240498 1.0 0.6862449963295184 5 Q9Y6K9,O60244,O15111 3 +P53 transcriptional gene network 0.5066459309498607 0.7441399681256966 0.4567918015528387 1.0 0.6862449963295184 6 P49327,Q709F0 2 +Neural crest cell migration in cancer 0.4712350314769888 0.7054444453554854 0.4805336930967856 1.0 0.7118576049101266 8 Q99523,P61586,P31751 3 +Degradation pathway of sphingolipids including diseases 0.4808808503002063 0.6884941741815152 0.4911416377298789 1.0 0.7239612027768353 7 P06280,O43681,P16278 3 +Dna damage response only atm dependent 0.3923491056673772 0.6740300882694413 0.5002921848647506 1.0 0.7302553407439024 15 O00443,P61586,P09429,P60953,P31751,Q99570,Q16822 7 +Nrf2 pathway 0.3821208477559157 0.6660867561691096 0.5053556492053863 1.0 0.7358471282332089 17 P09601,Q14914,Q15043 3 +Adipogenesis 0.3856652228042199 0.6598084209983334 0.5093767786491381 1.0 0.7398976565779452 16 P43490,P14174 2 +Glycosaminoglycan degradation 0.4855606935576075 0.6551559185508873 0.5123673724674467 1.0 0.7424352460268584 6 P15586,P16278 2 +Head and neck squamous cell carcinoma 0.4113847549862316 0.6306178706473847 0.5282904111974933 1.0 0.7603594442313195 11 P49815,P31751,P62753 3 +Vitamin dsensitive calcium signaling in depression 0.4740582943879832 0.607698763654876 0.5433872831861484 1.0 0.7736996999406912 6 P20020,P00390,O60341,Q8NB78 4 +G1 to s cell cycle control 0.3396960496057327 0.5947419617298442 0.5520159681513579 1.0 0.7743905810317699 24 P33993,O43913,P33991,P12004,P11802,Q14566,P24941,P49736,Q07864,P06493,Q9Y619,O75419,P14635 13 +Cysteine and methionine catabolism 0.4589727534672074 0.5941977305672139 0.5523798704889393 1.0 0.7743905810317699 7 P23526,P25325,P32929 3 +Nrp1triggered signaling pathways in pancreatic cancer 0.4189426228413556 0.5932455136272098 0.5530168572216636 1.0 0.7743905810317699 10 P36507,Q9NWH9,P24941,P49840,P31751,P28482,P27361 7 +Regulation of actin cytoskeleton 0.3159466306382251 0.5871401301365099 0.5571095976339335 1.0 0.7752783911129565 37 Q9UQB8 1 +Nuclear receptors metapathway 0.3104779427037312 0.5836699182357616 0.5594424097461737 1.0 0.7767142293452689 42 O14880,Q9HCL2,Q15067,P09601,Q14914,P08183,Q15185,Q15043 8 +Methylation pathways 0.3947019867549525 0.5761416532010442 0.5645194391527921 1.0 0.7819445595689487 4 Q9NZL9,P51580,P31153 3 +Pathogenic escherichia coli infection 0.3417983233815035 0.5622264120589074 0.5739617683440359 1.0 0.7902636415195899 22 O15143,P68371,P07437,P61586,Q9BUF5 5 +Cell migration and invasion through p75ntr 0.4265254014011114 0.5614416220187433 0.5744965166155813 1.0 0.7902636415195899 5 P61586 1 +Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence 0.3764120026422295 0.545040272491641 0.5857258197885788 1.0 0.8010214790270449 13 P43490 1 +Histone modifications 0.4082296815553827 0.5421806355642622 0.5876940739015812 1.0 0.8010214790270449 10 Q03164,Q15047,O75530,Q96KQ7 4 +G13 signaling pathway 0.365832580263002 0.5231281693145193 0.6008850637947527 1.0 0.809287835476867 15 Q7L576,P61586 2 +Novel intracellular components of rigilike receptor rlr pathway 0.3896678920326519 0.5215131627125138 0.6020093385590846 1.0 0.809287835476867 11 Q13526,Q9Y6K9,O15111 3 +Modulators of tcr signaling and t cell activation 0.3746911924883149 0.5213833117285994 0.6020997745239931 1.0 0.809287835476867 12 Q15366,Q9Y6K9 2 +Kisspeptinkisspeptin receptor system in the ovary 0.4516045807190138 0.5177995312633071 0.6045981454082743 1.0 0.809293930064439 6 Q05655,P27361,P31751,P28482 4 +Ampactivated protein kinase ampk signaling 0.370975877541418 0.5022905826207612 0.6154631326736149 1.0 0.8184464777834977 12 P49815,P49327,Q13085,O00763,P13639,P31751 6 +Onecarbon metabolism 0.3681349264283035 0.5013575949969047 0.6161194778591634 1.0 0.8184464777834977 13 P34896,P04818,P26358 3 +Praderwilli and angelman syndrome 0.4459336217284719 0.4957553496683667 0.6200670307101894 1.0 0.8207982645986321 6 Q7L576,Q15154 2 +Sphingolipid metabolism overview 0.4072702668321568 0.4808366746112829 0.6306325824687666 1.0 0.8220254404669295 5 O15269 1 +Sphingolipid metabolism integrated pathway 0.4072702668321568 0.4808366746112829 0.6306325824687666 1.0 0.8220254404669295 5 O15269 1 +Leptin signaling pathway 0.3165600564965199 0.4599397465809355 0.6455594698342357 1.0 0.8270766133260314 25 P36507,Q13085,Q9Y6K9,P61586,P62753,O00763,P49840,P60953,Q07666,P06730,O15111,P28482,Q06124,P27361 14 +Micrornas in cardiomyocyte hypertrophy 0.3317916808665904 0.4478959402818438 0.6542282984351226 1.0 0.8327810110144311 20 P61586,Q9Y6K9,P31751,O15111 4 +Type i interferon induction and signaling during sarscov2 infection 0.3243958953988684 0.4183683111786784 0.6756778517410786 1.0 0.8490757984388663 3 Q7Z434,P42224 2 +Osteopontin signaling 0.3586486992319807 0.416972464909362 0.6766985481823051 1.0 0.8490757984388663 4 P28482,O15111 2 +Nicotine effect on dopaminergic neurons 0.3569395573972309 0.4098635667952816 0.6819060327388486 1.0 0.8516692500943361 4 Q00535 1 +Neuroinflammation and glutamatergic signaling 0.3176300881722618 0.3922866302561609 0.6948464411013386 1.0 0.8598043530930688 21 Q13555 1 +Cytosolic dnasensing pathway 0.3469845579078292 0.384284202458925 0.7007678154140693 1.0 0.8643768301698335 12 P62875,Q9Y6K9,Q7Z434,Q86UT6,Q9NZI8,O15111,Q14258 7 +Type ii diabetes mellitus 0.34745550460774 0.3712560344606794 0.710446841020508 1.0 0.8727093911301302 4 Q05655 1 +Apoptosis 0.3689082975987092 0.3669280901942621 0.7136726577317858 1.0 0.8739030266938393 10 Q9Y6K9,O15111 2 +Burn wound healing 0.3911831010234372 0.3660253057234177 0.7143461926743611 1.0 0.8739030266938393 8 P07737,P08670 2 +Splicing factor nova regulated synaptic proteins 0.3362096527173516 0.3543729831817324 0.7230593788633388 1.0 0.8816239903624608 14 Q13555 1 +Ccl18 signaling pathway 0.3739972121586217 0.3412486402476284 0.732916408834386 1.0 0.8868018167340027 9 P08670 1 +Nonalcoholic fatty liver disease 0.2784875920968502 0.3367965374507635 0.7362702834585333 1.0 0.8868018167340027 44 Q9Y6M9,P20674,P00403,P08574,P14406,O14949,Q86Y39,P49327,P14854,P22695,O95298,P31751,P31930,O75251,P51970,Q9UDW1 16 +Biomarkers for pyrimidine metabolism disorders 0.4006587547911948 0.3318749288533592 0.7399837023540257 1.0 0.8868018167340027 6 P04818 1 +Endothelin pathways 0.370473224146333 0.3277367564685172 0.7431107093068423 1.0 0.8868018167340027 9 P42892 1 +Biotin metabolism including iems 0.3804638404926617 0.3262958608547748 0.744200519570746 1.0 0.8868018167340027 8 O00763,Q96RQ3 2 +Pdgf pathway 0.3285507237997421 0.3183226625846622 0.7502401954281033 1.0 0.890444128569737 14 P61586,P00403 2 +Retinoblastoma gene in cancer 0.2710119914306654 0.3097870477769697 0.756722901795106 1.0 0.8911062138079652 47 P26358,Q14566,P04818,P78527,Q16204,P09884,Q9Y619 7 +Erbb signaling pathway 0.322685583087885 0.3022985181965514 0.7624245078414327 1.0 0.8911062138079652 15 P31751,Q13555 2 +Il18 signaling pathway 0.2648215611112451 0.2999855916119419 0.764188146013139 1.0 0.8911062138079652 50 Q05655,P09874,P49327,Q9HC07,Q6IBW4,Q16836,P39687,Q9UIG0,P13639,P09601,P40939,Q9UMR5,O15111,Q32MZ4,Q9NZJ7,Q07866 16 +Physicochemical features and toxicityassociated pathways 0.3218051114315301 0.2982139667029295 0.765539862616132 1.0 0.8911062138079652 15 P07737,P61586 2 +Sphingolipid pathway 0.3817415090935812 0.2979721300055538 0.7657244349807137 1.0 0.8911062138079652 7 O95470,P04062,Q06136,O15269 4 +Pancreatic adenocarcinoma pathway 0.2949913550739388 0.2756092889518485 0.7828481743562268 1.0 0.9039852226125096 22 P61586,Q9Y6K9,P31751,O15111 4 +Neural crest cell migration during development 0.3730695252284439 0.2695865593222323 0.7874783417312545 1.0 0.9075763899875656 7 P61586,P31751 2 +Lung fibrosis 0.3762961119549205 0.2546087344788304 0.7990253123381019 1.0 0.9173425220497056 6 P09601 1 +Mrna processing 0.2411035277394927 0.247064761259834 0.804858104895712 1.0 0.9215450147835316 105 P52272,Q9UK45,Q9Y333,O00267,Q14103,Q92620,P31943,P62318,Q13243,Q15233,Q5KU26,Q15287,P14866,P55769,Q01130,P38159,Q09161,Q00839,Q15428,Q05048,O43390,Q15366,P62314,P62304,Q9UKA9,Q6P2Q9,P23246,P61978,Q08211,P62316,Q99873,P84103,Q96DI7 33 +Dna damage response 0.2888551374205926 0.2333264487252863 0.8155079222025452 1.0 0.9255859877469952 21 P49327,P11802,P06493,P78527,P38398,P41440,Q00535,P14635 8 +Mesodermal commitment pathway 0.2899247305173788 0.219885192521447 0.8259605687599454 1.0 0.9270247374371672 20 Q9BYW2,Q13085,Q86XI2,P63173,Q8N3C0,Q8IWS0,Q16204,P10644,Q9UPN3 9 +Ciliopathies 0.3007862365810831 0.2068742542466203 0.836108063701748 1.0 0.9330028299625112 15 Q99570,Q10713,O43924 3 +Mirna regulation of dna damage response 0.2811732570362807 0.2035459443887897 0.8387083387773433 1.0 0.934158354944168 22 P49327,P33993,P11802,P06493,P24941,P78527,P38398,P41440,P35251,Q00535,P14635 11 +Serine metabolism 0.340959042323131 0.159369987732123 0.873377382997766 1.0 0.9480114502721204 6 P34896,P04818 2 +Fas ligand pathway and stress induction of heat shock proteins 0.2856547863461804 0.1445956272804914 0.8850301498751876 1.0 0.9533599129718078 14 P09874,P78527 2 +Thermogenesis 0.2664949797277715 0.1419308744556268 0.8871346068880075 1.0 0.9533599129718078 23 O43772 1 +Tcell antigen receptor tcr pathway during staphylococcus aureus infection 0.2842079849409124 0.1348927714118779 0.8926966548917004 1.0 0.9550894318464964 12 Q9UHD1,Q9Y6K9 2 +Fatty acid transporters 0.3004306061609952 0.1310152762388939 0.8957632228793715 1.0 0.9566558927709924 5 O95573,P33121,O60488,Q01469 4 +Ras signaling 0.2573623070042334 0.1253432478804152 0.9002518152806176 1.0 0.9580219852451493 27 P61586,Q96KP1,Q9Y6K9,P31751 4 +Tolllike receptor signaling pathway 0.2786741902861072 0.1192084274249077 0.905110230142124 1.0 0.96091419052409 13 Q9Y6K9,P31751 2 +Urea cycle and metabolism of amino groups 0.3108462909683949 0.1178471629722155 0.9061887592379608 1.0 0.96091419052409 8 P52788,P12277 2 +Ranklrank signaling pathway 0.2694093844046158 0.0932141477157173 0.925733435073889 1.0 0.9752623056988704 14 Q9Y6K9,P31751 2 +Thyroid hormones production and peripheral downstream signaling effects 0.2668688288007046 0.0852596094063583 0.9320550015903448 1.0 0.9770170799606402 12 P49815,O60341,P62753,Q7LBC6,P28482 5 +Cerebral organic acidurias including diseases 0.2728147326629179 0.0763750897739719 0.9391206871892852 1.0 0.9801661717692364 5 Q92947 1 +Tcell receptor tcr signaling pathway 0.2594465029318752 0.07208177139962 0.9425368328009264 1.0 0.9820148153266196 17 Q05655,Q9Y6K9,P08670,O15111 4 +Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma 0.2850334289862216 0.0589123049569337 0.9530219571371584 1.0 0.9867820920727016 7 P28482,P27361,O75530,Q15022 4 +Pentose phosphate metabolism 0.2504140443855636 0.0437140280511959 0.9651323571384928 1.0 0.9919222712831404 5 P29401,O95336,P52209,P11413 4 +Rett syndrome causing genes 0.2502090715039172 0.0434559353604241 0.9653380898082152 1.0 0.9919222712831404 15 P27695,P49770,Q9UPW6 3 +H19 action rbe2f1 signaling and cdkbetacatenin activity 0.2700463883366443 0.0359461694956215 0.9713252817024882 1.0 0.9960452489231804 6 Q16527,Q15648,P06400,P11802,P35222 5 +Homologous recombination 0.2531477799867404 0.0193880544731324 0.9845315397683664 1.0 1.0 6 P28340,Q92878,Q9Y2S7,P49959,P27694 5 +Preimplantation embryo 0.2530580585863134 0.0191525266452802 0.9847194288964168 1.0 1.0 7 Q92945 1 +Atm signaling pathway 0.2341361320695767 0.0095162869596998 0.9924072161589188 1.0 1.0 15 Q9Y6K9,Q14676,P38398,Q12888,P06493,P14635 6 +Fragile x syndrome 0.2260517401922449 0.0038812718500467 0.9969032008897412 1.0 1.0 40 P49815,P05067 2 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..19763755d6eea959c867fb47a7a5ab7c3b15fbd8 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 and megakaryocytes in obesity", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirna targets in ecm and membrane receptors", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Srf and mirs in smooth muscle differentiation and proliferation", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAR2", "AARS", "AASS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSF2", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL8B", "ARMC8", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2L", "AURKA", "B3GALT6", "BAG4", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAT2", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BLVRA", "BPTF", "BRCA1", "BRD4", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "C1QBP", "CAB39", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPZB", "CARM1", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CEP44", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHUK", "CIP2A", "CISD1", "CKB", "CLASP2", "CLIC1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COASY", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DARS", "DAXX", "DBNL", "DCAF1", "DCAF7", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJB11", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPAGT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERCC2", "ERCC3", "ERI1", "ESD", "ESPL1", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC2", "EXOSC4", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FBXW11", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXRED1", "FSCN1", "FTO", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GCLC", "GCLM", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GLUL", "GM2A", "GMPPB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNPAT", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTPBP4", "GUSB", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IKBKG", "ILF2", "ILK", "IMPDH2", "INF2", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC2", "KMT2A", "KPNA1", "KPNB1", "KTN1", "L2HGDH", "LAMC1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM2", "LSM4", "LSM7", "LSS", "LTA4H", "LUC7L", "MACF1", "MAGT1", "MANF", "MAP1B", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARCKS", "MARK2", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MFAP1", "MFN2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOCS1", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MUT", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYLK", "MYO1C", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCAPG2", "NCAPH2", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCOR1", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NIPBL", "NKRF", "NLRX1", "NME1", "NME2", "NME3", "NONO", "NOP2", "NPC1", "NPC2", "NR2F1", "NSD1", "NSDHL", "NSF", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCRL", "OGDH", "OGT", "OPA1", "ORC2", "ORC5", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PIGT", "PIK3C2A", "PIK3R4", "PIN1", "PKM", "PKN1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPM1L", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPT2", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB2A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RB1", "RBBP4", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTF1", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARS", "SATB2", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC13", "SEC14L2", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SELENBP1", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SMYD3", "SNAP23", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOM", "STRAP", "STRN", "STUB1", "STX3", "STX4", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE1", "SYNE2", "TAB1", "TALDO1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCF20", "TCP1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMED10", "TMEM165", "TMEM43", "TMEM70", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP13", "TRMT2A", "TRRAP", "TSC2", "TSG101", "TSPO", "TSPYL1", "TTC19", "TTC26", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWISTNB", "TXNDC5", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2G2", "UBE2L3", "UBE2N", "UBR2", "UBR5", "UBTF", "UCHL5", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UPF1", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS18", "VPS33A", "WAPL", "WARS", "WASF2", "WDHD1", "WDR1", "WDR26", "WDR34", "WDR48", "WDR5", "WDR74", "WFS1", "WIPI2", "WNK1", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM3", "ZNF281", "ZNF318", "ZYG11B", "ZYX"], "leading_proteins": ["ABCB1", "ACACA", "ACACB", "ACAD11", "ACAT2", "ACOX1", "ACOX3", "ACSL1", "ACSL3", "ACSL4", "ADA", "ADH5", "ADK", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AKR7A2", "AKT2", "ALDH1A2", "ANP32A", "APEX1", "APP", "ARPC1B", "ASCC3", "ASNA1", "ATP2B1", "BAIAP2", "BANF1", "BAZ1B", "BCAT2", "BCLAF1", "BRCA1", "CAD", "CAMK2D", "CAMK2G", "CARM1", "CCDC6", "CCNB1", "CDC42", "CDC45", "CDK1", "CDK2", "CDK4", "CDK5", "CHKA", "CHORDC1", "CHST14", "CHUK", "CKB", "COASY", "COLEC12", "COPS6", "COX2", "COX5A", "COX6B1", "COX7A2", "CPOX", "CSNK1A1", "CSRP2", "CSTF1", "CTH", "CTNNB1", "CTPS1", "CYC1", "CYFIP1", "CYP51A1", "DCTD", "DCTPP1", "DDX5", "DHCR24", "DHCR7", "DHX38", "DHX9", "DLD", "DNMT1", "DYNLL1", "EBP", "ECE1", "EED", "EEF2", "EHMT2", "EIF2B2", "EIF4E", "ELOC", "EPHX1", "EXO1", "EXOC2", "EXOC6", "EXOC8", "FABP5", "FADS2", "FASN", "FECH", "FLNA", "G6PD", "GALNT1", "GBA", "GCDH", "GGCX", "GLA", "GLB1", "GNB1", "GNS", "GPAM", "GSK3A", "GSR", "GTPBP4", "HADH", "HADHA", "HEBP1", "HLA-A", "HLA-C", "HMGB1", "HMOX1", "HNRNPD", "HNRNPH1", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HS2ST1", "HSD17B12", "ICMT", "IGF2BP1", "IKBKG", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KLC1", "KMT2A", "LAMC1", "LBR", "LPCAT3", "LRP1", "LRRFIP1", "LSM2", "LSM7", "LSS", "MACF1", "MAP2K2", "MAPK1", "MAPK3", "MAT2A", "MAT2B", "MAVS", 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"SLC25A15", "SLC25A20", "SLC35B2", "SLC39A14", "SLTM", "SMS", "SNRNP40", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SORT1", "SPTLC1", "SRSF2", "SRSF3", "SRSF5", "STAT1", "SUPT5H", "SUZ12", "SYNE2", "TK1", "TKT", "TMEM165", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TRIM25", "TSC2", "TSPO", "TTC26", "TUBB", "TUBB4B", "TUBB6", "TYMS", "UBR2", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "VDAC1", "VDAC2", "VIM", "XPO5", "YBX3", "ZMPSTE24", "ZYG11B"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/opencell_localization/basic/idx2term.json b/opencell_localization/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..b8835e9dbf12618fab08e092cb679aa465a711c1 --- /dev/null +++ b/opencell_localization/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "vesicles"} \ No newline at end of file diff --git a/opencell_localization/basic/plot_0.png b/opencell_localization/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..dc657b5232ffb95cd2f76a440083eba4fd9fa93b --- /dev/null +++ b/opencell_localization/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5f2bcfea7441e95ad97a2683a6d5b55e8eb5ba219432f2420e75cc80c33b7fa0 +size 140528 diff --git a/opencell_localization/consensus.joblib b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..7da8bf8ad9356492efcdb23b18c846f33036e4ba --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6693fda05ee065c345f59ec1a9a9e069711e7f8813d04d568a90af207f26cab3 +size 66608 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9789baeb245505043338e27650aa0179415092ab --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 91.0 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bdc2c5f05c2aee5d37062c37a5873d22c5d71fb4 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3ccd7bc271b6d49a941b967afc6ec581e63ab0f1 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +nuclear_membrane 0.4124960445597361 1.393485867635729 0.163472915670898 0.9518983344507056 0.8173622180360839 32 P55735,O75531 2 +mitochondria 0.487775186041229 1.0419233992715045 0.2974471945866486 0.9975251861966647 0.8173622180360839 11 P45880,P21796 2 +vesicles 0.2662058300494375 0.7587133607064059 0.4480240427693343 0.9999590133199028 0.8173622180360839 156 O14976,P17812,Q99747,Q15125,Q8IXU6,O15269,Q6NT16,Q8NBN3,Q9UMY4,Q8IZ83,Q93050,P55735,Q5VW38,Q8IZA0,P61586,Q15392,P41440,P48449,P04439,O96005,O15027,O95425,Q06481,P53985,P31751,P13473,Q01968,P49257,Q06136,Q96L92,O14735,Q10713 32 +nucleolus_fc_dfc 0.3516449480777037 0.6285741631954327 0.5296278795086002 0.9999972991110028 0.8173622180360839 22 P55769 1 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0819c629218f3e3587b26064f50c4a44b111a44f --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP8L", "AKR1A1", "AKT2", "ALDH16A1", "ALDH9A1", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APLP2", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARPC2", "ARPC3", "ATG3", "ATG7", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG4", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BMS1", "BOP1", "BPNT1", "BRD2", "BRD4", "BTF3", "BUB1B", "BUD23", "BYSL", "C12orf57", "C1orf123", "C8orf33", "CAD", "CALD1", "CALM3", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDS2", "CHMP3", "CHMP7", "CHUK", "CKAP2", "CKAP4", "CKAP5", "CKB", 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"GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GLUL", "GNB1", "GNL2", "GNL3", "GOLGA2", "GOLT1B", "GORASP2", "GPR107", "GRB2", "GSK3A", "GSPT1", "GTPBP4", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HGS", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSF1", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "ILK", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "ITSN2", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KLC2", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "LAMP1", "LAMP2", "LAMTOR2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LMAN1", "LMNA", "LMNB1", "LPCAT1", "LSM14B", "LSS", "LTV1", "LZTS2", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MARK2", "MBOAT7", "MCM10", "MDH1", "MECP2", "MED14", "MED21", 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pval_100 pval_250 pval_500 +transporter 14 59 3.340370151527872 0.0008366679523248 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 2.113203132899288e-05 0.0001278957824949 4.362222344351095e-06 1.2512597553716874e-05 +metalloprotease 8 27 3.0366608529263583 0.0023921443743126 8.58495145631068 26.398058252427184 1.4262736372921438 0.246779453311036 3.321022586051017 1.6463540525991265 1.1083706824215755 0.2918245458017476 0.2336798458054532 0.0017566671607845 0.0002869398639522 0.0002308677663279 +esterase 1 5 2.869135418204612 0.0041159553659395 2.0679611650485437 7.684466019417476 0.7172320192268422 0.3647762514846939 1.5217653004191571 1.4253091833924298 1.0863934099472772 0.3032327374846778 0.0051137089586154 0.018640880521655 0.0970188007029606 0.2898287915273368 +oxidoreductase 14 41 2.748781445463525 0.0059817256425149 12.558252427184469 43.60436893203884 0.9664652969079414 0.3656199292680728 5.072676172192643 3.8442089013841825 1.3118377214144643 0.3470065139863294 0.078908455169182 0.0632956597671369 0.0019920697129915 4.827818755480527e-05 +serine protease 4 17 2.483027870369214 0.0130270894854058 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 0.0239365913087713 0.0001009929501613 0.0061967751678044 0.0302802497568866 +transmembrane signal receptor 2 6 2.429122244558359 0.0151354281383726 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 0.0746572323120207 0.058599533767272 0.3810529645432158 0.8308464049608552 +actin binding motor protein 3 8 2.361261150744798 0.0182128999541677 3.4441747572815533 7.160194174757281 -0.3046693197747457 0.510735955406928 1.8072910717434485 1.2784881701177822 0.951972036952174 0.317366704733812 1.0 0.1515272625734178 0.0006049883657283 0.0078812527225172 +acyltransferase 4 16 2.290674285498424 0.0219822589416556 5.550970873786408 17.609223300970875 0.8395368249042097 0.3495065414698917 3.0409541216574527 2.8086572783837886 1.152491475155923 0.3107783941454108 0.0179094063189584 0.0614247268920475 0.0793607883255565 0.0150707717640174 +secondary carrier transporter 3 14 2.10960086282299 0.0348927499705631 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 0.295480255529908 0.497470817800254 0.2431138696044149 0.4545916116320574 +hydrolase 3 23 2.013114370634077 0.0441025987544458 5.730582524271845 22.686893203883496 0.1039794126037792 0.5340059271703876 3.435640815918521 2.8019623945440895 0.9464611702434822 0.3066554522137604 0.2336798458054532 0.0949012099695084 0.0403511127078517 0.2663234719844228 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d16cb394bdadfaa099ac7501c36592bac0cb6ae7 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 158, + "title": "Average number of proteins per term", + "value": 13.329113924050633 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..87b4c89abd55bf6b3c8c7de2fd71b4fd8b5764bc --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..46248797b0641d21c510c8ae8365216996142eef --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,53 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +G-protein coupled receptor 0.866975512905364 3.641558986881344 0.0002709920152459 0.0419186048077877 0.0030583384577756 2 Q5VW38 1 +amino acid kinase 0.8285903375248196 3.4553413891936753 0.0005495964498265 0.0831946616799577 0.0043418119536297 2 P12532 1 +galactosidase 0.8176704169424265 3.401549693431156 0.0006700494527274 0.1004883713024402 0.004812173342315 2 P16278 1 +transporter 0.5316319270385284 3.340370151527872 0.0008366679523248 0.1238770713485041 0.0055080640194718 59 P55735,Q567V2,Q99805,Q99595,O60830,Q9H2D1,Q9HD45,Q9NR77,Q8NFH4,O43772,O43681,P41440,Q9Y619,Q9Y584 14 +voltage-gated ion channel 0.8761975927509762 3.2851470767167275 0.001019291492692 0.1488187506431595 0.0064419222338139 3 P45880 1 +metalloprotease 0.6505941481773526 3.0366608529263583 0.0023921443743126 0.3150514817593696 0.0130330624531518 27 Q9UIQ6,P42892,Q5JRX3,Q9NZ08,P31930,P55786,Q10713,O75844 8 +major histocompatibility complex protein 0.7932647591890674 2.8958495084774296 0.0037813368961496 0.4504105133961127 0.018670350924739 3 P10321 1 +esterase 0.933478065894932 2.8691354182046114 0.0041159553659395 0.4788216521996215 0.0197066953884379 5 Q9NUJ1 1 +deaminase 0.7640697328575128 2.7541291842857345 0.0058848534601156 0.606452503740432 0.0242336577312145 3 P00813 1 +oxidoreductase 0.5478725418947836 2.748781445463525 0.0059817256425149 0.6124656066111115 0.0242336577312145 41 O43169,O95831,P00403,O14949,Q8N4Q0,Q86Y39,Q15067,P09622,O95298,P30044,Q6DKJ4,P51970,O15254,Q9GZP4 14 +serine protease 0.6701848771930773 2.483027870369214 0.0130270894854058 0.8740417053379518 0.044745220406394 17 P42785,Q9HB40,P10619,P48147 4 +transmembrane signal receptor 0.8940826069004759 2.429122244558359 0.0151354281383726 0.9101559388974476 0.0508808009758059 6 Q8WUJ1,Q9UMX5 2 +aspartic protease 0.6211118464593055 2.3647496796501595 0.0180422611468276 0.9436800897372154 0.0544158568956605 2 Q8TCT9 1 +actin binding motor protein 0.8221990037139626 2.361261150744798 0.0182128999541677 0.9452055217378404 0.0544158568956605 8 Q9Y4I1,P09493,P67936 3 +homeodomain transcription factor 0.60820648577102 2.29179507163858 0.02191747120589 0.9698470918234164 0.0620213734425283 2 Q13330 1 +acyltransferase 0.6485382700909132 2.290674285498424 0.0219822589416556 0.9701610322574256 0.0620213734425283 16 Q9UKG9,Q9BWD1,Q6UWP7,Q8NCC3 4 +secondary carrier transporter 0.6365484254457267 2.10960086282299 0.0348927499705631 0.9963445458348668 0.0934416016160843 14 Q9UBX3,Q6NT16,Q15043 3 +hydrolase 0.5369841252416903 2.013114370634077 0.0441025987544458 0.9991965064698756 0.1104206909759217 23 P15586,O43865,P07099 3 +membrane trafficking regulatory protein 0.5415672847707226 1.946825937133313 0.0515556062862083 0.9997667207813028 0.1215788924361331 21 Q8WTV0,Q14108 2 +ion channel 0.6341059602648926 1.7845692067415333 0.0743312199060217 0.9999949882728334 0.167776182073592 4 O00299,Q96S66,P51790 3 +nucleotide phosphatase 0.7341509895657652 1.7525977448132268 0.0796710786637373 0.9999979908838194 0.1772962032235281 6 P49773 1 +oxygenase 0.7120397521452655 1.655530445862929 0.0978169458388302 0.9999999135913666 0.2146538533685442 6 Q16850,P30519 2 +small GTPase 0.6589064255331156 1.6052422495930674 0.1084405028607429 0.999999986703044 0.2318989730347042 8 P61586,P84095,P62826 3 +mitochondrial carrier protein 0.7004721911426826 1.6044680960519806 0.1086109114213171 0.9999999870986382 0.2318989730347042 6 Q9NZJ7,Q9Y6C9,Q70HW3 3 +nucleic acid metabolism protein 0.6858959184786043 1.5398763083162157 0.1235905067708809 0.9999999991134207 0.2536012996077816 6 Q9UGR2,Q9NYF8,Q8IWR0 3 +lyase 0.5239852661884689 1.4414282658900366 0.1494637295760943 0.9999999999922112 0.2989274591521886 14 Q9UHG3,P32929,Q9BU89,P22830 4 +primary active transporter 0.4566978714880599 1.2338362588355598 0.2172639252748469 1.0 0.4086630975407835 19 P05023,O60888,Q15388,Q6P4A7,Q9NS69 5 +pyrophosphatase 0.4756703078450833 1.2211538953253074 0.222027756813754 1.0 0.4127104185479194 3 Q9H2U2,Q9UKK9 2 +RNA helicase 0.4805117923901567 1.1446544012874489 0.2523523473587601 1.0 0.4440281511409725 13 Q7Z478,Q9H6R0,Q9H2U1,Q08211,Q92620,Q8IX18 6 +RNA methyltransferase 0.5442737107749254 1.1390152793677204 0.2546967813723872 1.0 0.4440281511409725 9 Q9BV44,O43148,Q8IY81,Q7Z2T5,Q08J23,Q7Z4G4 6 +tubulin 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.4440281511409725 6 Q9BUF5,P68371,P07437 3 +reductase 0.3992294047611455 1.129829589692102 0.2585480373732245 1.0 0.4440281511409725 28 Q15392,P35270,Q14914,Q14739,Q8N8N7 5 +protein modifying enzyme 0.3839817504265209 0.8851930857677113 0.3760525008338191 1.0 0.5882801498192418 23 O75718,Q86X55,P50897,Q9UMR5,O60725,Q86YN1,Q9H488 7 +glucosidase 0.377027474346235 0.6780226504786241 0.497757331874981 1.0 0.7149605312386091 3 Q13724,P10253 2 +membrane traffic protein 0.2833955173901687 0.5755839796000267 0.564896412125278 1.0 0.7694278716878786 58 O14976,A6NIH7,O43493,P11717,P49257,Q99523,Q96ED9 7 +oxidase 0.3703466911004464 0.5292244113496547 0.5966497843740608 1.0 0.8057321874453129 14 P20674,P14406,P36551,P50336,Q15800 5 +protease inhibitor 0.4129950895344176 0.4518249217702897 0.651395114457481 1.0 0.8319093726304491 8 P05067 1 +replication origin binding protein 0.3263819927176363 0.4274215797652453 0.6690722922745129 1.0 0.8457073774349844 3 O75419,O43913 2 +DNA metabolism protein 0.2890270593771045 0.3725402462423324 0.7094906526973759 1.0 0.8655826558681832 37 P09874,P28340,P33991,Q14566,Q8IWS0,Q07864,P09884,Q9NRF9,Q9NYB0,Q96QE3 10 +zinc finger transcription factor 0.3803242593224378 0.3660145612796396 0.7143542100578035 1.0 0.8655826558681832 9 Q5VZL5,Q9UGU0,Q9H1B7,Q9UPT8 4 +protease 0.2860502877941036 0.354104370375874 0.7232606669369259 1.0 0.8655826558681832 38 P60900,P20618,P50579,P49721,P28074 5 +acetyltransferase 0.3387159309632029 0.3460483341215715 0.7293063906878259 1.0 0.8655826558681832 12 P11182,Q6P1A2,Q96N66 3 +transaminase 0.345460432054817 0.2741892805193896 0.7839391654803327 1.0 0.8866329720839206 10 O15382 1 +DNA helicase 0.3433624055660286 0.266406960365068 0.7899258052736644 1.0 0.8866329720839206 10 P51532,P13010,P46063,Q9H4L7 4 +cysteine protease 0.281038699013811 0.2242747636623951 0.8225435117469528 1.0 0.8866329720839206 24 O15484,Q13867,P53634,Q99538,Q93009,Q9Y5K5,O94966,Q86UV5 8 +carbohydrate kinase 0.3335541570056388 0.2176980894286138 0.8276643523956906 1.0 0.8866329720839206 5 P00558,Q01813,P17858,P51570 4 +non-motor microtubule binding protein 0.2981879836280524 0.2150705593580819 0.82971230702543 1.0 0.8866329720839206 17 O43663,Q9ULW0,Q96CW5,P60520,Q66K74,O75351,Q9UH99,Q9BSJ2 8 +methyltransferase 0.29257521682671 0.1746653695612349 0.8613425804986856 1.0 0.8919107292035741 15 P34896,P04818,Q8N6R0,Q5T280,Q9BV86 5 +ATP synthase 0.2745739749170184 0.1716843295015331 0.8636857061275116 1.0 0.8919107292035741 22 Q93050 1 +non-receptor serine/threonine protein kinase 0.2356272679820938 0.0634614409408078 0.9493990629961924 1.0 0.9583834233989148 46 Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O15111,Q00535 8 +transferase 0.2427539600910922 0.0597965096134759 0.9523177055293016 1.0 0.9583834233989148 30 O14880,Q7LGA3,Q2TAA5,O14735,P43490 5 +kinase 0.2327177071079158 0.0093449762496336 0.9925438962513328 1.0 0.9925438962513328 20 Q13057,Q53H12,P42356,O00443,P35790,P52789,Q9UBF8,Q9HA64,Q16822 9 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7c7c9a3a733d27f7e2e53de8a45c9fa92a6adce9 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "C4 zinc finger nuclear receptor", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "Lambda repressor-like transcription factor", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic helix-loop-helix transcription factor", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APLP2", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGDIA", "ARHGEF1", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATL2", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG6", "BAIAP2", "BAP18", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCKDHA", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CDS2", "CEBPZ", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNP", "COASY", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DSTN", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM3C", "FAM98A", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPD2", "GPI", "GPR107", "GPRASP2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN2", "HMGN4", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "ISCU", "ISG20L2", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "METAP1", "METAP2", "METTL13", "MFAP1", "MFSD5", "MGEA5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MIPEP", "MMAB", "MMS19", "MOGS", "MON2", "MORF4L1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCDN", "NCKIPSD", "NCOA5", "NCOR1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NENF", "NFS1", "NHP2", "NIP7", "NIPBL", "NIT2", "NKRF", "NKTR", "NLN", "NLRX1", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD3", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC2", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PCYOX1L", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PDZD8", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHF14", "PHF3", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIK3C2A", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RAC1", "RACGAP1", "RAD18", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIPK1", "RNASEH2A", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTN4IP1", "S100A11", "SAAL1", "SACM1L", "SAE1", "SAMHD1", "SAP130", "SAP18", "SARM1", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SCAF1", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC39A14", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A6", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYNCRIP", "SYNGR2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TES", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM87A", "TMLHE", "TMOD3", "TMPO", "TMX2", "TMX3", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAP1", "TRAPPC4", "TRIM21", "TRIM24", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSPYL1", "TSTA3", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE3C", "UBE4A", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UPF2", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", 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0000000000000000000000000000000000000000..b86a6d92ac3d42965ceb49ea30d5302174140c48 --- /dev/null +++ b/pharos_dto/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:993b7f3f59f8ff7b968205a74169a7e79ba72d65ec1fcc676792c790eb54ee2a +size 137774 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f7fc7765ea48e9c5712cacdeacd67d1cb9cca98b --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1db5ea7c2a4d95f5186268c2761ace1cfc2f1f9f702915fd95283e7f0f341fd9 +size 777235 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ec3ea06b29b14401b73e1dca821576a08882fbcf --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,11 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Receptor 5 22 3.729433818507298 0.0001919105019285 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 1.200625690464637e-05 0.0005317154146911 0.0422820747053583 0.1428239412840529 +Protease 37 107 3.304984820842858 0.0009498154389637 23.87864077669903 112.97330097087378 0.5565894930811873 0.44121745363286 8.615285022365173 8.917462185063522 1.4311973593718734 0.3778605174872721 0.1598900155921283 0.0003656061160771 0.0012692067816645 0.0026235599249437 +Metalloprotease 9 37 2.9337898207956625 0.0033485087261817 10.080097087378642 37.81310679611651 1.0846602244748076 0.3802793741361127 4.2814674000125414 2.184793664748831 0.9789887795730944 0.3416347995760264 0.3024216363859021 0.0006633301665035 0.0003462124150969 0.0007310207327381 +Serine protease 9 27 2.8753202554094983 0.0040361788007174 5.475728155339806 28.060679611650485 -0.0299555241091654 0.3004695585307199 2.9431330647424168 1.972802334926414 1.5768370330864625 0.2828311561719579 0.0327224420542492 0.0002266749410996 0.0025776990482271 0.0004229506315236 +SLC superfamily of solute carriers 12 40 2.6550379378683187 0.007929948955792 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.0119412685134754 0.0979989328881401 0.0124295299930757 0.0593739065116454 +Dehydrogenase 13 55 2.641350660611041 0.0082576202888013 14.00485436893204 56.08009708737864 -0.4370363771193292 0.4692872079440394 7.431563212064344 3.4983896420583886 1.174195224675972 0.3512016895000671 0.0121763996061447 0.0145704521374391 0.0005643259136828 0.0002563222355264 +Oxidoreductase 26 111 2.5495309011284086 0.0107867951228755 26.983009708737864 113.91747572815534 0.6392672411957 0.4324241122550336 10.483097938966514 7.235161275092307 1.3581321831066435 0.3819609334162012 0.0195472198633937 0.0041482795575296 3.1227581482175416e-06 3.6106574113802257e-06 +Actin binding motor protein 3 8 2.361261150744798 0.0182128999541677 3.400485436893204 7.016990291262136 -0.3266016906233755 0.5103074691239311 1.7810490410657198 1.1091861224675832 0.9387464349855232 0.3165822920421544 1.0 0.1432798584585485 0.0004714775801565 0.0062633876942655 +SLC25 family of mitochondrial transporters 6 18 2.1961651078722624 0.0280801278117615 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0140700862732742 0.048990890514732 0.0017882188023504 0.0017617577033715 +Writer 5 11 2.001240261498744 0.0453665040623372 3.2766990291262137 9.402912621359222 0.100981103301605 0.4673481501477311 2.224344733160938 1.612388706819648 1.0736681315847354 0.3097033619248117 1.0 1.0 0.4559893986318888 0.0308662830144804 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a990414e827d614c5252d8b3b03ad2c7a4a8d2a3 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 1956, + "title": "Average number of proteins per term", + "value": 3.1431492842535786 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..716b101b23677cc0e620d6393b59072421133645 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d36a1779ec7530692a09bd080dbfaaedb99be545 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,86 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC35 family of nucleotide sugar transporters 0.9136333553937814 3.862152450722985 0.0001123923917498 0.1973623187982092 0.0003371771752496 2 Q8IXU6 1 +Miscellaneous SLC25 mitochondrial transporters 0.90701522170748 3.8312334078375176 0.0001275024772735 0.2207401703182033 0.0003744667350556 2 Q9Y6C9 1 +Receptor 0.812672609887704 3.729433818507298 0.0001919105019285 0.3129944895578737 0.0005154699419922 22 Q9UQB8,Q567V2,A6NIH7,Q8WTV0,Q14108 5 +Nucleoside kinase 0.8838517538054288 3.7220589610698247 0.0001976048641891 0.320605492765992 0.0005244438457992 2 P55263 1 +CAMK2 family 0.8825281270681699 3.715774770667619 0.0002025819808015 0.327188781731321 0.0005340301272882 2 Q13555 1 +Protease 0.4469813533472295 3.304984820842858 0.0009498154389637 0.8441282709704834 0.0018267836761191 107 O15484,P17812,Q8NHP8,Q96AE4,Q99797,P29144,P42785,Q99538,P55786,P67812,Q9HB40,O43847,Q5JRX3,Q13867,Q86TI2,P27708,P48147,P42892,Q7L5N1,P22695,Q9NZ08,Q15366,P10619,Q99497,P31930,Q9NVG8,Q9H3G5,O75844,P08243,Q15365,Q9UIQ6,P34913,P53634,Q93009,Q9Y5K5,Q92945,Q10713 37 +Galactosidase 0.7951687624090056 3.289529184931714 0.0010035514852502 0.8596943923472613 0.0019087548145897 2 P16278 1 +Metalloprotease 0.5846496042060463 2.9337898207956625 0.0033485087261817 0.9985850674897656 0.0052147158187989 37 Q9UIQ6,P42892,Q5JRX3,Q7L5N1,Q9NZ08,P31930,P55786,Q10713,O75844 9 +Serine protease 0.6275619646887399 2.8753202554094983 0.0040361788007174 0.9996332173347002 0.0060822540325141 27 P48147,Q9HB40,Q96AE4,Q15365,P42785,Q15366,P10619,Q92945,Q9H3G5 9 +Lysine-specific demethylase 0.681005956320323 2.6951913337805955 0.0070348222438239 0.9999989932069488 0.0097520285676254 2 Q8NB78 1 +CDK1 subfamily 0.6786896095301178 2.6826582928525524 0.0073039577000875 0.9999994075331172 0.0100609445502613 2 P06493 1 +VRK family 0.6743878226340227 2.6593306358681432 0.0078296084106335 0.9999997897530304 0.0106352180911105 2 Q8IV63 1 +SLC superfamily of solute carriers 0.5406279667223886 2.6550379378683187 0.007929948955792 0.9999998274895244 0.0107169155494961 40 Q9HC07,Q8TB61,Q9Y6C9,O43772,Q8IXU6,Q6NT16,Q70HW3,Q9Y619,P41440,Q9H2D1,Q9UBX3,Q15043 12 +Dehydrogenase 0.4686022252910179 2.6413506606110415 0.0082576202888013 0.9999999095946914 0.0110705313810113 55 O95831,Q8N4Q0,P23378,Q13423,P30837,P09622,Q14914,O75251,P51970,Q8N8N7,P00390,Q9NZ01,Q8IZ83 13 +ERK subfamily 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999999909959814 0.0124413911506775 2 P28482 1 +MAPK family 0.6628060886829972 2.5961877970707183 0.0094264528043477 0.9999999909959814 0.0124413911506775 2 P28482 1 +Oxidoreductase 0.3900724278807336 2.5495309011284086 0.0107867951228755 0.999999999387573 0.0140472511720003 111 P00403,Q8N4Q0,O95298,Q14914,O75251,P00390,Q8IZ83,O43169,O95831,Q15392,P09622,P36551,Q15800,P51970,Q8N8N7,Q96CU9,Q9UDW1,Q16850,O15260,Q9NZ01,P23378,Q13423,Q15067,P30837,Q14739,O15254 26 +Intracellular chloride channel (clic) family 0.6336863004632761 2.4352325804956534 0.0148822205034764 0.9999999999998168 0.0185902052817924 2 O00299 1 +Deaminase 0.7617722529542215 2.4046582747322223 0.0161875947955891 0.9999999999999865 0.0199640198109536 4 P00813 1 +Guanyl-nucleotide exchange factor 0.6933379005153766 2.400134019135281 0.0163890702232909 0.9999999999999908 0.0201419165602802 3 Q9Y4G8 1 +CDK4 subfamily 0.6273990734612909 2.4000652493473984 0.0163921496210344 0.9999999999999908 0.0201419165602802 2 P11802 1 +Actin binding motor protein 0.8221990037139626 2.361261150744798 0.0182128999541677 0.9999999999999998 0.0220311888128337 8 Q9Y4I1,P09493,P67936 3 +Lysine demethylase 0.6812313803376335 2.3380020832117436 0.0193871400771872 1.0 0.023293148643107 3 Q8NB78,Q7LBC6 2 +CK1 group 0.6746110559417395 2.3038338707647683 0.0212319710032893 1.0 0.0252613961571982 3 Q8IV63,P48729 2 +Carbohydrate kinase 0.6055592322965 2.2767527992697008 0.0228009916054321 1.0 0.0267699517288266 2 P17858 1 +Antibacterial response protein 0.5929847782925294 2.204943792372091 0.027458038986889 1.0 0.0314449205259689 2 P40222 1 +SLC25 family of mitochondrial transporters 0.6120174277690443 2.1961651078722624 0.0280801278117615 1.0 0.0320634734382985 18 Q9Y6C9,O43772,Q9Y619,Q9H2D1,Q9UBX3,Q70HW3 6 +Protein arginine methyltransferase 0.6946186834613906 2.083570907496288 0.0371992156014804 1.0 0.0408773402901661 4 Q86X55 1 +Writer 0.6625860831185703 2.001240261498744 0.0453665040623372 1.0 0.0486229490114693 11 O96028,P26358,Q96KQ7,Q86X55,Q99873 5 +Mitochondrial amino acid transporter subfamily 0.7223605923201639 1.9476216832210524 0.0514602472985505 1.0 0.0550034118666475 5 O43772 1 +Transporter 0.3222861581891827 1.9434612382371423 0.0519604543837921 1.0 0.0555077273482782 176 Q8TB61,Q9HD45,Q9Y6C9,P24390,Q8IXU6,Q6NT16,Q9Y584,Q15043,Q70HW3,P55735,Q93050,Q9BQE5,O43772,P41440,Q99805,O43493,Q99523,Q9UBX3,P00846,Q9HC07,P49257,P50542,Q8NFH4,P08183,Q9Y619,Q9H2D1 26 +Nucleotide phosphatase 0.6906186658995417 1.8721542421512625 0.0611852675059896 1.0 0.0652553888995178 9 P49773,Q5TFE4 2 +TK group 0.5849303667501949 1.8278724957724208 0.0675686897767908 1.0 0.071984944010568 3 Q13308 1 +Esterase 0.6629061852565659 1.735742239942161 0.0826094211496508 1.0 0.0878651591999549 9 Q969T7,Q9UMR5 2 +Phosphatase 0.470135713033541 1.710321663033361 0.0872064080341488 1.0 0.0927042033232582 29 Q01968,Q86YN1,Q5TFE4,O43681,Q9NPH0,P49773,Q9H857,P10586 8 +Hydrolase 0.3449051375796096 1.7012090749159126 0.088903734379252 1.0 0.0944571995903405 98 P15586,O43865,O43924,P00813,Q5TFE4,Q8NCC3,Q969T7,Q9UMR5,P16278,Q9NPH0,P49773,P10586 12 +DNA-directed DNA polymerase 0.6887280523047328 1.6444034746467149 0.1000928878737552 1.0 0.106229890765635 7 Q9NRG0,Q9NR33 2 +Protein methyltransferase 0.6203662083146982 1.6411550754517086 0.1007652285155784 1.0 0.1068854593147893 10 Q99873,O96028,Q86X55,Q96KQ7 4 +Small GTPase 0.4852771564105227 1.5927210512613348 0.1112227828510303 1.0 0.1178503592939411 22 Q9UI26,P61586,Q14141,P62826 4 +Phosphatase inhibitor 0.6517496842247665 1.473999832580833 0.1404816362432575 1.0 0.1485308543198981 7 Q9H0U9,P39687,P55209,Q99733 4 +SET domain 0.6018905915547546 1.3809554816579512 0.1672926492149411 1.0 0.176591700952199 5 Q9BZ95,O96028 2 +Enzyme 0.2678322658108658 1.272398461662854 0.20323158038222 1.0 0.2138359178201303 616 Q8N4Q0,Q9BWD1,Q8NCC3,P42785,Q969T7,Q14914,Q9NPH0,P22830,P49773,P55786,Q13126,O95831,Q9HB40,P00813,Q15392,P09622,P48147,O43865,O43924,Q16850,P11182,P42892,Q7L5N1,Q9NZ08,O15260,P10619,Q9H3G5,O75844,Q9Y2W6,Q15365,Q9UIQ6,Q9UQ84,Q13423,P30837,Q9UMR5,P16278,Q14739,O15254,P10586,P15586,Q6P1A2,Q7Z478,Q8NHP8,Q5TFE4,O43681,Q9Y3B2,Q8IZ83,O43169,Q5JRX3,O15382,Q08J23,Q15800,P51970,Q8N8N7,Q9UDW1,Q9BV10,Q14566,P50897,P40939,P31930,Q9UKG9,O14880,Q15067,P53634,Q92945,Q10713,P00403,Q15125,Q99797,O95298,O15269,Q10472,P04818,P46063,Q86YN1,P32929,O96005,P32321,Q9Y6A4,Q9NRG0,Q9NR33,Q15366,Q96N66,Q9NZ01,P23378,Q14CX7,Q9HCG8,Q9BV86,O15484,Q96AE4,Q9NPF4,Q99538,O75251,P35250,P00390,P67812,Q13057,P42694,P36551,O00178,Q96CU9,Q9H4L7,Q9Y6M9,P22695,A0AVT1,P35573,Q8N5L8,Q8NCH0,Q9H857,P49327 110 +Phosphatase modulator 0.561345969661682 1.2254570523942372 0.2204030622382113 1.0 0.2316541589134559 9 Q9H0U9,P39687,P55209,Q99733 4 +Pyrophosphatase 0.4756703078450833 1.2211538953253074 0.222027756813754 1.0 0.2332364620449532 3 Q9H2U2,Q9UKK9 2 +Oxidase 0.4436628612487583 1.1449292062149137 0.2522384843551934 1.0 0.2642627077658052 19 O43169,P20674,P14406,Q15067,O15260,P36551,Q15800,O15254 8 +CAMK group 0.5506664354660719 1.1352913745187934 0.2562532550205205 1.0 0.2683251428373331 5 Q13555 1 +Tubulin 0.5946395689336473 1.1317330086018254 0.2577466996457822 1.0 0.269744539597191 6 Q9BUF5,P68371,P07437 3 +V-type ATPase 0.5489472520298224 1.0736468533664958 0.2829809897297914 1.0 0.2952057684861184 8 Q93050 1 +DNA helicase 0.463154584285083 1.0146589606029162 0.3102684232802681 1.0 0.32332713688663 12 P33991,Q14566,P49736,P46063,Q9H4L7 5 +Mitochondrial nucleotide transporter subfamily 0.5365075364492734 1.0136107240826049 0.3107685384624066 1.0 0.3236758579512605 8 Q70HW3 1 +Reductase 0.4424063016792834 1.009934575419534 0.3125266361382701 1.0 0.3253337415042344 16 Q15392,Q14739 2 +Membrane trafficking regulatory protein 0.3878319640761247 0.913469372994523 0.3609957343072532 1.0 0.3745929211167041 23 P55735,P24390,P50542 3 +Bromodomain 0.5276945543124053 0.898434539241759 0.3689539295405306 1.0 0.3824450907160985 7 P25440,Q9NPI1 2 +Other group 0.4374701400475536 0.8895651283310353 0.3736994376920837 1.0 0.3871589513377731 13 Q96KB5,O14976,O14965,O15111 4 +Helicase 0.369828045604747 0.8470478877434536 0.3969684299940832 1.0 0.4103965375625934 25 Q14562,Q7Z478,P33991,Q14566,Q08211,P49736,P42694,P46063,Q92620,Q8IX18,Q9H4L7 11 +Acetyltransferase 0.3728597872402851 0.8040941938647175 0.4213425775297423 1.0 0.4349055839832063 23 Q6P1A2,Q9BWD1,P11182,Q96N66,Q9UKG9 5 +Transaminase 0.5184709995434167 0.7949737407740828 0.4266287772504429 1.0 0.4401296879229253 6 O15382 1 +RNA helicase 0.4225101198678302 0.7811935314203583 0.4346886776454677 1.0 0.4482082516998075 12 Q7Z478,Q08211,P42694,Q92620,Q8IX18 5 +Cysteine protease 0.322272443996533 0.6477215641329539 0.5171650543056763 1.0 0.5324078138010014 38 Q9Y5K5,O15484,Q96FW1,P17812,P08243,Q8NHP8,Q13867,P53634,Q99538,Q99497,Q93009,P27708,O94966,Q9NVG8,Q06203 15 +Extracellular matrix glycoprotein 0.4068777219080087 0.6331926955594518 0.5266078151375178 1.0 0.5415588256619267 4 Q9Y2T2 1 +Extracellular structure 0.4504036226113923 0.6114535184556977 0.540899381332923 1.0 0.5559638412439293 8 O75718,Q5KU26,Q9Y2T2 3 +Signaling 0.3718532092529322 0.6040411267108213 0.5458162995685525 1.0 0.5607230472458449 17 P43490,Q8WUJ1 2 +G-protein 0.3256074795088903 0.5503407208361736 0.5820856992426839 1.0 0.596729364632437 29 Q9UI26,P61586,Q14141,P62826 4 +Intracellular calcium-sensing protein 0.3692574161701202 0.5233408841192941 0.6007370546908373 1.0 0.6148831391812023 14 P80303,Q14257,P60660 3 +Calmodulin 0.3692574161701202 0.5233408841192941 0.6007370546908373 1.0 0.6148831391812023 14 P80303,Q14257,P60660 3 +Polymerase 0.3401596796569339 0.4988013660906402 0.6179193250884762 1.0 0.6321392258750311 20 P62875,P30876,Q9NRG0,Q9NR33,Q9H9Y6,P35250 6 +Calcium-binding protein 0.3493869167265089 0.4734268313116748 0.6359086910640324 1.0 0.6495234463296331 17 P60660,Q02818,Q14257,P80303,P43307,O43852 6 +Lyase 0.3358530706421725 0.4443991920146889 0.65675399750565 1.0 0.6704649369107784 19 P32929,P22830 2 +Replication origin binding protein 0.3263819927176363 0.4274215797652453 0.6690722922745129 1.0 0.6826840916478598 3 O75419,O43913 2 +Protease inhibitor 0.3810811941166516 0.4188354491602697 0.6753363954941154 1.0 0.6883574724265188 10 P05067 1 +Non-motor microtubule binding protein 0.3395446591126682 0.4001429501104762 0.6890512312753709 1.0 0.7019709418617841 16 Q9UH99,Q96CW5,Q66K74,Q9BTW9 4 +Methyltransferase 0.3483348203518617 0.390656495991011 0.6960511596184755 1.0 0.7084042293026566 12 Q08J23,P34896,P04818,Q9BV86 4 +Epigenetic regulator 0.296272932741459 0.3906033428172551 0.6960904543556778 1.0 0.7084042293026566 31 P25440,O96028,Q9BZ95,P26358,Q96KQ7,Q9NPI1,Q86X55,Q86U86,Q99873 9 +Immune response 0.3815833057303888 0.3798910185148757 0.7040263146286108 1.0 0.7157356920028912 5 Q9NUQ3,Q6P2E9,P40222,P78318 4 +F-type and V-type ATPases 0.3281532926357523 0.3584486298196839 0.7200076046526278 1.0 0.731222676376189 17 Q93050 1 +Nucleotidyltransferase 0.2984618112879303 0.3577428629197207 0.7205357530819967 1.0 0.7313793113795461 29 Q9NPD3,P30876,Q9NRG0,Q9NR33,Q8NFW8,Q9H9Y6,P35250 7 +PI3/PI4 kinase family 0.309139990074572 0.3513310407766978 0.7253400101825362 1.0 0.7358739937329051 3 P42356 1 +P-type ATPases 0.3478633102835708 0.2618570124470556 0.7934316825364891 1.0 0.8016282908271553 5 P05023 1 +Unclassified protein 0.2933573184988222 0.2198639811537928 0.8259770887882003 1.0 0.8332187651726249 19 P12532,P52789,Q9HA64,O75569 4 +Protein kinase 0.2390996485596149 0.1605448066185894 0.8724519287622676 1.0 0.8791942156924242 59 O14976,Q05655,Q9Y6K9,Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O15111,O95747,Q00535 12 +Enzyme modulator 0.2264099403547931 0.1035119101023876 0.9175566973769578 1.0 0.9213248973661856 112 P49815,P46379,P61586,P55209,Q7L576,Q14141,Q99733,Q96ED9,P05067,Q9Y4G8 10 +CDK family 0.2944960862234612 0.0743239660581762 0.9407526076113956 1.0 0.942680379348304 7 P11802,P24941,Q00535,P06493 4 +DNA-directed RNA polymerase 0.2584352006735152 0.0644449354025046 0.9486159510875652 1.0 0.9500731184471466 12 Q9H9Y6,P62875,P30876,P62487 4 +Kinase 0.2203282241707843 0.0361186999946359 0.9711877116163432 1.0 0.9721817624982432 95 O14976,P35790,O14965,Q00535,Q9Y6K9,Q13555,Q96KB5,P55263,Q9HA64,P12532,Q05655,O75569,P78527,P31751,O15111,P04183,Q13557,P52789,O95747 19 +Ion channel 0.2429922306168851 0.03505383589543 0.9720368123869452 1.0 0.972534017917578 5 O00299,Q96S66,P51790 3 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ff84be541f0eafd3de7774ba7033df859ef6d6bf --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S12, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S21, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L51, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP synthase-coupling factor 6, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 2, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase family 16 member A1", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Annexin", "Antibacterial response protein", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Apoptosis-stimulating of p53 protein 2", "Arfaptin-1", "Arginase-2, mitochondrial", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Arylsulfatase A", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-adducin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Beta-mannosidase", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "Bifunctional coenzyme A synthase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "Bromodomain-containing protein 7", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 7", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "COUP-TF-like receptors", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-regulated heat-stable protein 1", "Calcium-transporting ATPase type 2C member 1", "Calcium/calmodulin-dependent protein kinase type ii subunit delta", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calpain-5", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division control protein 45 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centromere/kinetochore protein zw10 homolog", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Condensin-2 complex subunit D3", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1C", "Coup transcription factor 1", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-K", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystathionine gamma-lyase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-binding protein SATB2", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxycytidylate deaminase", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dual specificity mitogen-activated protein kinase kinase 3", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase CBL", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase ZNF598", "E3 ubiquitin-protein ligase listerin", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Erythrocyte band 7 integral membrane protein", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2 subunit 3", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 1", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 6B", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP41", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Folate transporter 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GDP-L-fucose synthase", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIF subunit 2", "General vesicular transport factor p115", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine synthetase", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Heat shock factor protein 1", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group nucleosome-binding domain-containing protein 4", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 1", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT2", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase NSD3", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase SMYD3", "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "ILK subfamily", "ITPK1 family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit alpha", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol polyphosphate 5-phosphatase OCRL-1", "Inositol-tetrakisphosphate 1-kinase", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intersectin-2", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lambda repressor-like transcription factor", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit gamma-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat flightless-interacting protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 5", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "M-phase phosphoprotein 8", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAP7 domain-containing protein 1", "MAPK family", "MARK subfamily", "MCU family", "MFS-type transporter SLC18B1", "MLCK family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mediator of RNA polymerase II transcription subunit 14", "Mediator of RNA polymerase II transcription subunit 21", "Mediator of RNA polymerase II transcription subunit 25", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine aminopeptidase 1", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import inner membrane translocase subunit Tim22", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light chain kinase, smooth muscle", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 6", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] 1 subunit C2", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NLR family member X1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nf-kappa-b essential modulator", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor", "Nuclear receptor coactivator 5", "Nuclear receptor corepressor 1", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase 3", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 3", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Origin recognition complex subunit 2", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 3", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 14", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PITSLRE subfamily", "PKC delta subfamily", "PKC family", "PKD family", "PKN family", "PLK family", "PMS1 protein homolog 1", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Paxillin", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal carnitine O-octanoyltransferase", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal targeting signal 1 receptor", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phospholipase DDHD2", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 39", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor CWC22 homolog", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX34", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable ribosome biogenesis protein RLP24", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein Hook homolog 2", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein SCAF8", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SEC13 homolog", "Protein SET", "Protein Wiz", "Protein angel homolog 1", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c delta type", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase 1L", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIPK family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 6", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras GTPase-activating-like protein IQGAP3", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p25-like protein", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 1", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SCY1 family", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC18 family of vesicular amine transporters", "SLC19 family of vitamin transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC35 family of nucleotide sugar transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC41 family of divalent cation transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC64 Golgi Ca2+/H+ exchangers", "SLC7 family", "SLC9 family of sodium/hydrogen exchangers", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Scy1-like protein 2", "Sec1 family domain-containing protein 1", "Sec1 family domain-containing protein 2", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Separin", "Septin-11", "Septin-2", "Septin-6", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 2", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase d3", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 19 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein F", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-dependent HCO3- transporters", "Sodium/hydrogen exchanger 6", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Solute carrier family 41 member 3", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptosomal-associated protein 23", "Syntaxin-12", "Syntaxin-18", "Syntaxin-3", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Terminal uridylyltransferase 4", "Testin", "Testis-specific Y-encoded-like protein 1", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid adenoma-associated protein", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription initiation factor IIB", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 115", "Transmembrane protein 165", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tuberin", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone C", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm3", "U6 snRNA-associated Sm-like protein LSm4", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "UDP-glucose:glycoprotein glucosyltransferase 1", "UDP-glucuronic acid decarboxylase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Unconventional myosin-Va", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4B", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 34", "WD repeat-containing protein 74", "WD repeat-containing protein 82", "WNK family", "Winged helix/forkhead transcription factor", "Wiskott-Aldrich syndrome protein family member 2", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCCH domain-containing protein 7B", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 1", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 3", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter ZIP14", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG12", "ALYREF", "ANAPC1", "ANGEL1", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APLP2", "APOL2", "APP", "ARCN1", "ARFIP1", "ARG2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG7", "ATIC", "ATL2", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRIX1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC40", "CDC42", "CDC45", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKN2AIP", "CEBPZ", "CFAP20", "CHAF1A", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTOP", "CHUK", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CROT", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CWC22", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCPS", "DCTD", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX34", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLGAP5", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DSG2", "DSP", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "EPHA7", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC1", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FOXRED1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNPDA1", "GNS", "GOLGA2", "GPATCH4", "GPD2", "GPI", "GPR107", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2F2", "GTF3C3", "GTF3C5", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HEATR1", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN2", "HMGN4", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK2", "HPRT1", "HSD17B10", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LRRC47", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LTN1", "MACF1", "MAGED2", "MAGT1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "MED21", "MED25", "METAP1", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MORF4L1", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL51", "MRPL9", "MRPS12", "MRPS16", "MRPS2", "MRPS21", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYEF2", "MYL6", "MYLK", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCL", "NCOA5", "NCOR1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS7", "NEK9", "NFS1", "NHP2", "NIPBL", "NKRF", "NLN", "NLRX1", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD3", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCRL", "OLA1", "OPA1", "ORC2", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDHX", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIK3C2A", "PIK3R4", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNP", "PNPT1", "POGZ", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1G", "PPM1L", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PXN", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAPGEF2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RBMXL1", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIPK1", "RNASEH2A", "RNH1", "RNPS1", "ROCK1", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCA", "S100A11", "SAE1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCPEP1", "SCYL2", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A7", "SLC7A1", "SLC9A6", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP23", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPNS1", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK4", "STOM", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM22", "TJP1", "TJP2", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM165", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1B", "TP53", "TP53BP1", "TP53BP2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRMT6", "TROVE2", "TSC2", "TSFM", "TSG101", "TSPYL1", "TSTA3", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UGGT1", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP3", "UTP6", "UXS1", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VRK1", "VRK3", "WARS", "WASF2", "WDHD1", "WDR1", "WDR33", "WDR34", "WDR74", "WDR82", "WIZ", "WNK1", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZC3H7B", "ZCCHC11", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF598", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ADA", "ADK", "AGL", "AHCYL1", "AIFM1", "AKT2", "ALDH16A1", "ALDH1B1", "ALG12", "ANP32A", "AP3M1", "APOL2", "APP", "ASNA1", "ASNS", "ATP1A1", "ATP6", "ATP6V0A1", "AURKA", "BAG6", "BAIAP2", "BCAT2", "BLMH", "BRD2", "BRD7", "CAD", "CALU", "CAMK2D", "CAMK2G", "CAPN5", "CARM1", "CDC45", "CDK1", "CDK2", "CDK4", "CDK5", "CFAP20", "CHKA", "CHRAC1", "CHST14", "CHUK", "CKMT1A*", "CLCC1", "CLCN3", "CLIC1", "CLPTM1", "CMAS", "COASY", "COLEC12", "COPS6", "COX2", "COX5A", "COX7A2", "CPOX", "CPVL", "CROT", "CRTAP", "CSNK1A1", "CTH", "CTPS1", "CTSA", "CTSC", "CWC22", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DBT", "DCTD", "DHCR24", "DHX29", "DHX38", "DHX40", "DHX8", "DHX9", "DLD", "DNMT1", "DOLPP1", "DPP9", "EBP", "ECE1", "EDC4", "EHMT2", "EPHX2", "ERAP1", "EXO1", "EXOSC1", "EXOSC4", "FASN", "FECH", "FN3KRP", "FOXRED1", "FUBP1", "GAK", "GALNT1", "GLB1", "GLDC", "GNS", "GSR", "GTPBP1", "HADHA", "HELZ", "HINT1", "HK2", "HOOK2", "IGBP1", "IKBKG", "IPO11", "KDELR1", "KDM1B", "KDM3B", "KHSRP", "LBR", "LGMN", "LMAN1", "LNPEP", "LPCAT3", "MAP1S", "MAPK1", "MBOAT7", "MCM2", "MCM4", "MCM6", "MGST3", "MIPEP", "MPV17L2", "MSMO1", "MTAP", "MTCH2", "MYL6", "MYO5A", "NAA25", "NAMPT", "NAP1L1", "NAP1L4", "NDUFA8", "NDUFB9", "NDUFC2", "NDUFS7", "NNT", "NPEPPS", "NRDC", "NSD2", "NSD3", "NSUN2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUCB1", "NUCB2", "NUDT5", "NUP37", "OCRL", "ORC5", "OSGEP", "OTUB1", "OXSR1", "PARK7", "PBK", "PBRM1", "PCBP1", "PCBP2", "PDE6D", "PEX5", "PFKL", "PI4KA", "PITRM1", "PLA2G15", "PLBD2", "PMPCA", "POLE4", "POLR1B", "POLR2B", "POLR2G", "POLR2L", "PPA2", "PPAT", "PPT1", "PPT2", "PRCP", "PREP", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PTGR1", "PTGR2", "PTK7", "PTPRF", "RAN", "RAPGEF2", "RCN2", "RECQL", "RFC2", "RHOA", "RPP25L", "SCARB1", "SCARB2", "SCPEP1", "SEC11A", "SEC13", "SEPT6", "SHMT1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC35B2", "SLC35F2", "SLC39A14", "SMARCAD1", "SORT1", "SPTLC1", "SSR1", "SUN2", "SURF4", "TBC1D13", "TBCD", "TDRKH", "TECR", "TGOLN2", "TIMM22", "TK1", "TM9SF2", "TM9SF3", "TMEM165", "TPM1", "TPM4", "TPP2", "TSC2", "TSPYL1", "TUBB", "TUBB4B", "TUBB6", "TUBGCP3", "TXLNA", "TXLNG", "TYMS", "UBA6", "UCHL5", "UNC119B", "UQCR10", "UQCRC1", "UQCRC2", "USP19", "USP7", "VRK3", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..577277ffe210c7e974817cc6f2273abdcf58fb6c --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tchem"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..40770ce0112b1a7ef6f3bff23a266bbef4af8b44 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9156edfd6c974441d3cb9d0c8be44a73773d8be29a94f81f54c24914ee83cc0b +size 209299 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..5ebda3d70a1ac6744a80e742d2e3d1f2faaad420 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tchem", "1": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..fbd7dfa7aa9cc298d22d0e3ec0fd572bce8dc6f9 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6f689bac7f81fb2a0669bb8ce7a4dd98eb50bc5cdd87db481115bd550acd06d8 +size 139116 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..d9d530537aeebcb6818584f1b18bf73112e505a4 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fa3aba5b75b63f2eda44888dd54df368897922fc03a23ba18d456cd60dfe6aef +size 133858 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..aba3d4d649ab6dcbee997795bb33023ff7b13cc0 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6fbdd926d9a4844d2836437ba760e9938d25c0ec5f9718e19fb3497d6d7938a6 +size 76408 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..61b7e8fd3f49c587c263c1a6e3f3204b423db8f8 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Tchem 46 305 2.8280663374568795 0.0046830101328552 59.439320388349515 318.5218446601942 -0.2305334187536127 0.615521577515179 22.555943558835885 30.16438793527643 1.14481176642065 0.379503350430493 0.0672679154402013 9.163527811582716e-05 0.0001719418885549 0.0014744391798045 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d9bb934a6992cf108936eb74b42e9e028b883201 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 755.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5aee29504f07543a935b54518240b575013460c3 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..41643d24de3b776c1abc0407c36ffbc7d6347e37 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tchem 0.323740397394252 2.8280663374568795 0.0046830101328552 0.0186008673516303 0.0103534948963552 305 P30536,O14976,P11717,Q8WTV0,P50579,Q86X55,Q15125,P07099,P42785,P09601,P35790,O15269,O14965,Q9H773,P55786,Q13126,P14174,Q13555,O75530,Q5JRX3,O15382,P55263,P30519,O60725,P41440,O60502,P05067,P48449,P27695,P48147,O43865,Q99523,Q16850,Q9NPI1,P42892,P78527,Q9NZ08,P10619,Q13427,P43490,P45880,Q9UIQ6,P53634,P16278,P08183,P10586 46 +Tclin 0.3502799287968813 1.6193786906478913 0.1053658088879052 0.3594073254004488 0.1404877451838736 77 P26358,O95298,O75251,P00390,P05023,P00813,P04818,P49721,P51970,P28074,P20618,Q9Y6M9,P09874,Q05655,O43924,Q86Y39,Q99720,Q9BU61,P09884,P68371,P28340,Q9BUF5 22 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8ef7da8b849e3bb7963315a398a7c36aed2340fa --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRI3BP", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf57", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C5orf15", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACUL1", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA7", "COASY", "COG3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH4", "GPATCH8", "GPD2", "GPHN", "GPI", "GPR107", "GPR180", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZIC", "LZTS2", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFR1L", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFB", "NELFCD", "NEMF", "NENF", "NES", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "ODR4", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THEM6", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM126A", "TMEM161A", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM70", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC27", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UACA", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13C", "VPS18", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASF2", "WASHC4", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WRAP53", "XAB2", 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sha256:0b7bb785ebe08115ebddcce14b35f6f634a069fa3b06daf86fcd9117dd704cbf +size 138643 diff --git a/protein_atlas_biological_process/consensus.joblib b/protein_atlas_biological_process/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..8bef853e4aa3fd1bbc11ccdb6e528ca38fd7bb0e --- /dev/null +++ b/protein_atlas_biological_process/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f953772bc0c65933513139923c4e4d245f1d8ac7a7e50e9f169fddc411618169 +size 99729 diff --git a/protein_atlas_biological_process/df_merge.tsv b/protein_atlas_biological_process/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5482c398242c8ef5fad7358a1ece74120c07826d --- /dev/null +++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,15 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Translocation 11 50 3.6423485523328423 0.0002701619258942 12.434466019417476 47.86165048543689 1.1297087783550883 0.3515144245437065 6.687771513864753 3.601211391947168 1.550426642680832 0.3811939235350816 0.0004573916663925 0.0007060425621212 1.3539029440989637e-06 4.897211079555433e-05 +Lipid metabolism 36 112 3.3586161318637124 0.0007833379898416 32.65533980582524 126.3009708737864 0.0122638234126047 0.3570579745388888 13.120525890444084 12.789813112229345 1.8284441878622113 0.3670562446523409 0.0035808658277258 0.0006759353496621 1.3898899342271148e-05 4.767447989416664e-06 +Lipid biosynthesis 19 47 2.939727480298226 0.0032850103411183 15.9126213592233 54.70145631067961 0.536392080403718 0.3712014565741516 7.84820404428356 6.53895703030749 1.480689631873909 0.3519149032884112 0.4557340909954169 0.1147508609141721 0.0095337053279706 6.777781022525243e-06 +Nucleotide metabolism 2 10 2.716488492427771 0.0065978488806734 2.825242718446602 9.657766990291265 0.1031324982165795 0.4462534906167557 2.086373657371837 1.6478473348312213 1.124114753923129 0.2978561945400932 0.0051137089586154 0.0011613234829685 0.0150601402708497 0.088385561156941 +Cholesterol metabolism 6 21 2.6778329185279226 0.0074100171711162 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 0.1988423464133734 0.0008840144918394 0.0006723458545905 0.0055591316089767 +Sterol metabolism 6 22 2.662574618188581 0.0077545374478062 7.606796116504855 25.203883495145632 1.1785484151208083 0.2872927387372206 3.1377365577760563 3.096691699470945 1.2399567569518877 0.3064799172119154 0.2106238865633207 0.0011293669878184 0.0009539854611851 0.0079620077053278 +Steroid metabolism 6 23 2.6444240944031208 0.0081830057877509 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.237457799625543 0.0018806372047711 0.0019598595015423 0.0164244734054917 +Transport 99 461 2.584607435716086 0.0097489926250846 127.39320388349516 491.7621359223301 1.4832290368286314 0.5289485259644714 40.31460927260851 50.077723312236 2.248556521823017 0.4543981544818752 0.0040849658877666 0.0007734144438178 5.763752945750993e-06 2.723717385254151e-07 +Lipid transport 6 21 2.55517883945049 0.0106133252148243 5.140776699029126 21.796116504854368 0.7022879686929654 0.35525802853007 2.5598823127228028 3.5727100026626353 1.209238263022456 0.2984698606617377 0.0402962873689797 0.0003875215520721 0.019727566606408 0.0373784288289189 +Steroid biosynthesis 5 19 2.382574250315392 0.0171920645683589 6.351941747572815 21.094660194174757 1.1936032046421512 0.306057763510231 2.838692628881621 2.6297902443336034 1.071011617665077 0.2981933340003868 0.1373006943976843 0.0028960612595367 0.0006702441173732 0.0027845492980534 +Phospholipid metabolism 7 14 2.3471941639012166 0.0189153948531248 5.706310679611651 15.194174757281552 0.9499140430417652 0.282763149469861 3.1039684871946744 2.8053632837701987 1.3505948321648105 0.2868829019946007 0.2067156970649581 0.3655284832956332 0.3123584546310498 0.0017199102450681 +Cholesterol biosynthesis 4 13 2.2970198884086384 0.0216176352042885 4.478155339805825 14.449029126213592 1.241205081084055 0.2669045154832569 1.9237928998467095 1.7749125587996368 0.9260618360685376 0.2641298712278396 0.0892490045576324 0.014058804472369 0.0009487109772629 0.0017429018144962 +Sterol biosynthesis 4 14 2.2490727726722324 0.0245078664878835 4.970873786407767 15.854368932038836 1.2489526119817105 0.2730082640054638 2.2746228138386324 2.237837752303934 0.9571049414552286 0.2704007779320353 0.1026081339138497 0.018640880521655 0.0016919334745771 0.0034992238505004 +Purine salvage 1 5 2.1144546894903 0.0344764508435089 1.203883495145631 4.978155339805825 0.7681087001497898 0.4029938560290594 1.3427925061534858 0.146176164319549 0.9596088570072956 0.304895906276926 0.0242848323540905 0.0471521402185075 0.0054816148577098 0.0213301790272909 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0858e2fdf6e01be49970f0e031c423d6b81e1935 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 168, + "title": "Average number of proteins per term", + "value": 29.136904761904763 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..02ac45ae29a21c701bb77158de87a135aa035693 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..31b2b3007b0e0d50c89e86381255a76868badeee --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,59 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Viral RNA replication 0.8888153540701544 3.7455803522009856 0.0001799772284423 0.0297862739452698 0.0017104144389306 2 Q15365 1 +Translocation 0.6034162416140423 3.6423485523328423 0.0002701619258942 0.0443784720689096 0.0020630547068287 50 P55735,Q99595,O60830,Q9Y584,Q5JVF3,Q8NFH4,O60220,Q9Y5J9,Q5SRE5,Q9Y5L4,Q9NS69 11 +Glycogen biosynthesis 0.8464592984778301 3.5425772888789107 0.0003962372912531 0.0644129228656376 0.0028942549969795 2 P31751 1 +DNA excision 0.8395102581072174 3.508767148886812 0.0004501888576373 0.0728581989979299 0.0030206372677412 2 Q9UQ84 1 +Lipid metabolism 0.4434813789769287 3.3586161318637124 0.0007833379898416 0.1233542947915498 0.0045379580101171 112 Q6P1A2,Q9HCL2,Q8NHP8,Q15125,Q8NCC3,P35790,Q14914,O15269,Q9NPH0,Q9H6V9,Q15392,P07602,Q15800,Q99943,Q15185,O15118,P48449,O95864,Q16850,P40939,Q96N66,P61916,Q9NZ01,Q9UKG9,Q9Y6X9,O14735,Q8IVS2,P49327,Q06136,Q15067,O00116,Q6UWP7,Q14739,Q9UBM7,O15254,Q9Y217 36 +Prostaglandin metabolism 0.8653759280660556 3.235424095075437 0.0012146217529673 0.1846847907053251 0.0061835289241975 3 Q14914 1 +Prostaglandin biosynthesis 0.7319655857048376 2.966042330100404 0.0030165896697937 0.3980332029196855 0.0144796304150101 2 Q15185 1 +Lipid biosynthesis 0.5428255947547904 2.939727480298226 0.0032850103411183 0.4246577489219428 0.0153300482585524 47 Q6P1A2,Q9HCL2,Q15125,P35790,Q15392,Q15800,Q99943,Q15185,P48449,O95864,Q16850,Q96N66,Q9NZ01,O14735,Q8IVS2,P49327,O00116,Q6UWP7,Q14739 19 +Nucleotide metabolism 0.8371905392110157 2.716488492427771 0.0065978488806734 0.6711361459145536 0.0283583490431256 10 Q969T7,P00813 2 +Cholesterol metabolism 0.6511308622626383 2.6778329185279226 0.0074100171711162 0.7133571028414776 0.0283583490431256 21 Q16850,Q15392,Q15800,Q14739,P61916,O15118 6 +Sterol metabolism 0.6399217163881344 2.662574618188581 0.0077545374478062 0.7295964257372729 0.0283583490431256 22 Q16850,Q15392,Q15800,Q14739,P61916,O15118 6 +Steroid metabolism 0.6280492749177685 2.6444240944031208 0.0081830057877509 0.7485222141469798 0.0286405202571284 23 Q16850,Q15392,Q15800,Q14739,P61916,O15118 6 +Transport 0.3011818875623996 2.584607435716086 0.0097489926250846 0.8071546355000079 0.0334251175717188 461 A6NIH7,Q99595,Q9BZF3,P24390,Q8IXU6,Q6NT16,Q9NS69,Q70HW3,Q93050,P55735,O60830,Q9BQE5,O43772,Q9HD20,Q96ED9,O15118,Q13769,Q99523,Q99720,Q9Y5J9,O00461,P61916,P00846,O43823,P45880,P46379,P08183,Q9Y5L4,Q9H2D1,P84103,Q9Y6C9,Q9Y282,O43681,O60220,Q5SRE5,Q9Y584,Q15043,P21796,O43169,Q5JVF3,Q9Y4I1,P41440,P51970,Q9UDW1,Q86Y39,Q8IYI6,Q96KP1,P31930,Q9UBX3,Q9UKG9,P49257,P50542,Q8NFH4,Q9BTX1,Q9Y619,Q92945,P00403,P11717,Q8TB61,Q9H2U1,Q9BUR5,Q14849,O95298,Q13505,Q9NZJ7,Q9UI26,Q09161,O95197,Q96T51,Q9Y487,Q96PU8,Q4V328,P31751,Q9Y3B3,A0AVF1,Q9NV70,O14949,P63167,Q99747,Q92621,Q15388,O75251,Q9C0C9,P62826,Q6P4A7,Q92973,Q96CU9,Q9Y6M9,O95864,O15027,O14617,P22695,P53985,Q9Y5X1,O95487,P56134,Q08211,Q8NFH3,Q96L92 99 +Lipid transport 0.6321598773420005 2.55517883945049 0.0106133252148243 0.8334680517805294 0.0349615418841274 21 Q9BZF3,Q9BQE5,Q9BUR5,Q99720,P61916,O15118 6 +Steroid biosynthesis 0.6304396020127812 2.382574250315392 0.0171920645683589 0.945708237211419 0.0544956008959303 19 P48449,Q16850,Q15392,Q15800,Q14739 5 +Phospholipid metabolism 0.6782381696585624 2.3471941639012166 0.0189153948531248 0.9595717035479474 0.058841741216991 14 Q6P1A2,Q9HCL2,P35790,Q6UWP7,Q9NPH0,Q96N66,O14735 7 +GMP biosynthesis 0.6108537392455401 2.306811067048229 0.0210653550155215 0.9720345779634229 0.0605001896148446 2 P49915 1 +Cholesterol biosynthesis 0.6785910677663045 2.2970198884086384 0.0216176352042885 0.9745640777782136 0.0605001896148446 13 Q16850,Q15800,Q15392,Q14739 4 +Sterol biosynthesis 0.6608956683935553 2.2490727726722324 0.0245078664878835 0.9845263197300628 0.064700948158874 14 Q16850,Q15800,Q15392,Q14739 4 +Purine salvage 0.7589707352536059 2.1144546894902994 0.0344764508435089 0.9972447419608754 0.0804450519681874 5 Q13126 1 +Transcription termination 0.6153591525984679 1.9920393998872103 0.0463667350972571 0.9996563836427388 0.1052650202208001 3 Q9H0D6,Q08211 2 +Phospholipid biosynthesis 0.610134944980396 1.910002232793132 0.0561329258361444 0.9999390434300334 0.1257377538729636 13 Q6P1A2,Q9HCL2,P35790,Q6UWP7,Q96N66,O14735 6 +Cell shape 0.7623318976414883 1.8751850654903228 0.0607672680157005 0.9999733375026088 0.134327645087338 6 Q7L576,P35580 2 +Immunity 0.3739119382181814 1.7487725694416745 0.0803303401448776 0.9999992234805274 0.1678753489237413 72 P04439,Q8IV08,P10321,P14174,O43823,Q9H2U1,P46379,Q9UQ84,P78527,Q9NZ08,Q15366,Q14166,O60828,Q7Z7L1,Q9NUD5 15 +Sensory transduction 0.7267627822578357 1.7202461071750104 0.0853877151749167 0.9999996925170006 0.1694029950825563 6 P50897,Q9H6K4,O43924 3 +Vision 0.7267627822578357 1.7202461071750104 0.0853877151749167 0.9999996925170006 0.1694029950825563 6 P50897,Q9H6K4,O43924 3 +Notch signaling pathway 0.7121941917405551 1.65621093075509 0.0976791104093492 0.9999999683298598 0.1886217304456399 6 Q92542,Q9H488,P05067 3 +Fatty acid metabolism 0.3917275611841499 1.4449166327404577 0.1484813038032593 0.9999999999981266 0.2802793150443546 46 Q8IVS2,O95864,Q8NCC3,Q15067,O15254,P40939,Q14914,Q9NZ01,Q15185,Q9UKG9,Q9Y6X9 11 +Porphyrin biosynthesis 0.612677867843148 1.432540717073582 0.1519891340198453 0.9999999999990636 0.283713050170378 5 P36551,P22830 2 +Sphingolipid metabolism 0.5981965017158201 1.4119147627494175 0.1579750603674115 0.9999999999997152 0.2884761971926644 9 P07602,O15269,Q9NZ01 3 +Differentiation 0.3152477799492586 1.2799953167238918 0.200546782997959 1.0 0.3509568702464283 83 Q9Y2W6,Q00839,O96005,Q13555,Q13769,Q99523,P46379,Q9H2U1,Q99598,Q7L576,Q08J23,Q14141,Q6DKJ4,Q9Y4G8 14 +mRNA capping 0.5109315264050454 1.1551704924384545 0.2480206156734872 1.0 0.4251781982974066 4 Q09161 1 +DNA condensation 0.564473408953986 1.148824335903977 0.2506284224031949 1.0 0.4253088380175429 8 P42695,Q86XI2 2 +Exocytosis 0.4692643963238125 1.1423548527149905 0.2533065493777251 1.0 0.4255550029545782 15 O00443,Q8IYI6,Q8TAG9,Q96KP1,Q9NV70 5 +Antiviral defense 0.4068113147675969 1.132269876856254 0.2575209903779232 1.0 0.428351746371199 25 Q9BYW2,Q92841,Q9H2U1,Q7Z434,Q9NUD5,Q15366,Q9Y3Z3,Q9NV70,Q92499,O95801,Q7Z7L1,Q14258 12 +Protein transport 0.2551763750254898 1.1030176762110395 0.2700194890331473 1.0 0.4404201374521237 231 P84085,A6NIH7,Q99595,Q99747,Q92621,P24390,O60220,Q5SRE5,Q15388,Q13505,Q9NT62,Q9NS69,Q9Y584,Q9UMY4,Q9Y2T2,P55735,O60830,Q5JVF3,Q9Y4I1,Q9UI26,P62826,Q9HD20,Q96D46,Q9H267,Q96ED9,Q92973,Q08379,Q8IYI6,Q96T51,O15027,O14617,Q4V328,Q96KP1,Q8N1F7,Q9Y5J9,Q9Y3B3,Q9BXS5,Q9UBQ0,Q9Y5X1,O43823,P49257,P50542,O95487,Q8NFH4,Q9H4A6,Q8NFH3,A0AVF1,Q9BTX1,Q96L92,Q9Y5L4,Q9NV70 51 +Inflammatory response 0.4906744562033022 1.057977499916664 0.2900657003999156 1.0 0.464105120639865 11 Q08211,Q8IV08,P14174,P09429 4 +Innate immunity 0.3259051789352641 1.049881022605285 0.2937728177250158 1.0 0.4656022016773836 58 P04439,P10321,P14174,O43823,Q9H2U1,P78527,Q15366,Q14166,O60828,Q9NUD5 10 +Respiratory chain 0.3781116202065125 1.0021802141380924 0.3162565620403974 1.0 0.4935592960564898 30 Q9Y6M9,P00403,O14949,Q86Y39,O95298,P31930,O75251,P51970,Q96CU9,Q9UDW1 10 +Electron transport 0.3525911761777997 0.9710780020452996 0.3315094372307392 1.0 0.5109503252730659 42 O43169,Q9Y6M9,P00403,O14949,O95864,Q86Y39,O95298,P31930,O75251,P51970,Q96CU9,Q9UDW1 12 +Heme biosynthesis 0.5520836996708663 0.942110377531883 0.3461361319651015 1.0 0.5280977585321458 6 P36551,P22830 2 +Fatty acid biosynthesis 0.4567690314070701 0.8715686928238077 0.3834437161241246 1.0 0.575165574186187 11 Q8IVS2,P49327,Q13085,O95864,Q9H7Z7,P38398,O00763,Q9NZ01,Q15185 9 +Neurogenesis 0.3258184914769515 0.7510993959489932 0.4525928392481859 1.0 0.6320474378535748 44 Q13555,Q9Y4G8,Q8WUJ1,P55209 4 +Cilium biogenesis/degradation 0.3704026829238941 0.692847730484548 0.4884051148182404 1.0 0.6650864170278695 20 P21333,A6NIH7,Q01968,O95684,O14965 5 +mRNA transport 0.2921718995857551 0.6888826519566204 0.4908971173300942 1.0 0.6650864170278695 67 P55735,Q5JVF3,Q13769,Q92621,Q8NFH4,Q08211,Q96PU8,Q5SRE5,Q9BTX1,Q92945,P84103,Q09161 12 +Spermatogenesis 0.3428561608753979 0.5916935659083304 0.5540558058207348 1.0 0.7160105798298726 23 Q9Y2W6,P46379,Q08J23,Q14141 4 +Adaptive immunity 0.3810899135452807 0.4799776083034783 0.6312433150709726 1.0 0.7914095293427119 11 Q9NZ08,P04439,P10321 3 +Cell adhesion 0.3118896926703529 0.4552275561403237 0.6489455378758882 1.0 0.8075766693566608 27 P00813,P05067 2 +Glycogen metabolism 0.415764449388195 0.3839033380875433 0.7010500921608149 1.0 0.8473123416044382 6 P49840,P62140,P31751 3 +Biological rhythms 0.2802678192782946 0.3266717332708653 0.7439161818827289 1.0 0.8863682167113366 41 Q8WXF1,Q03164,P23246,Q15233,P63244,P78527,Q14103,Q08211,P17844,Q93009,P06493,P43490,P62140,Q00535,Q00839 15 +One-carbon metabolism 0.3391866668975824 0.2511884746541974 0.801668394863607 1.0 0.918166585026306 10 P34896,O43865 2 +Amino-acid biosynthesis 0.2978134570667796 0.1466949765682691 0.8833727838267711 1.0 0.9763593926506418 11 O15382 1 +Nucleotide biosynthesis 0.3189201235332613 0.122265193204533 0.9026889969418236 1.0 0.9868728565169684 7 P04818 1 +ER-Golgi transport 0.2431377514740318 0.119810263005157 0.904633451807221 1.0 0.9868728565169684 48 P55735,O95197,O95487,P49257,Q99747,O15027,P24390,Q9Y282 8 +Gluconeogenesis 0.2446487285340163 0.0721907958621129 0.9424500699011168 1.0 0.9957963002728782 4 P60174 1 +Potassium transport 0.2157162729021304 0.0328210576066919 0.9738172857159708 1.0 1.0 4 P05023 1 +Symport 0.2563829686049981 0.022220845652146 0.9822717892694024 1.0 1.0 6 P53985,Q9H936 2 +Sodium transport 0.200728718118588 0.0030472535047404 0.9975686472385396 1.0 1.0 5 Q9Y6M7,Q92581,P55011,P05023 4 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bb8392ab12dc4bfd814c6489c5af0c5d2a17f815 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Carnitine biosynthesis", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Cysteine biosynthesis", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEX1", "API5", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARG2", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL8B", "ARMT1", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATRX", "AUP1", "AURKA", "BABAM2", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BIRC6", "BMS1", "BOP1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C2CD5", "CACUL1", "CACYBP", "CAD", "CADM1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARM1", "CARS", "CBL", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC51", "CCDC86", "CCNB1", "CCNK", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CENPV", "CEP55", "CFL1", "CGGBP1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP2", "CLCC1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CLU", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COG3", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CROT", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCPS", "DCTD", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDHD2", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPY30", "DPYSL2", "DSG2", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FIS1", "FKBP15", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXK2", "FOXRED1", "FRYL", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCC2", "GCLC", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GINS3", "GINS4", "GLUL", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPHN", "GPI", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSS", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP4", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK2", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBKG", "ILF2", "ILF3", "ILVBL", "IMP4", "IMPDH2", "INA", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "ISG20L2", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITSN2", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIF11", "KIF18A", "KIF18B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRR1", "LAMC1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPPRC", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "LZTS2", "MACF1", "MAGT1", "MANF", "MAP1S", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "MFAP1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MIA3", "MICU1", "MIF", "MINDY3", "MKI67", "MLEC", "MMS19", "MOCS1", "MON2", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MRC2", "MRE11", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTERF3", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MYBBP1A", "MYCBP2", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCKAP1", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFA", "NELFCD", "NES", "NFS1", "NHP2", "NIP7", "NIPBL", "NKRF", "NLE1", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NR2F1", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT16", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PDZD8", "PECR", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLIN3", "PLK1", "PLRG1", "PMS1", "PMVK", "PNN", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POP1", "PPAT", "PPHLN1", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RANBP6", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN3", "RNASET2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP14", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL24D1", "RTCB", "RTF1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCFD2", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDE2", "SDF4", "SDHA", "SDHB", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SELENBP1", "SENP3", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SON", "SORT1", "SPC24", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPTLC1", "SPTLC2", "SRCAP", "SREK1", "SRFBP1", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNGR2", "TACC3", "TAF6L", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBCB", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TK1", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM214", "TMLHE", "TMX1", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOLLIP", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TP53", "TP53BP1", "TP53BP2", "TPI1", "TPR", "TPRKB", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC26", "TTC4", "TTF2", "TTLL12", "TUBB2B", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNL1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAPA", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS18", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VTA1", "WAPL", "WARS", "WASF2", "WASHC4", "WBP11", "WDR12", "WDR33", "WDR36", "WDR41", "WDR43", "WDR48", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "WRAP53", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZMYM2", "ZMYND8", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWILCH", "ZYG11B", "ZYX"], "leading_proteins": ["ABCB1", "ACACA", "ACACB", "ACOX1", "ACOX3", "ACP6", "ADA", "AGPAT1", "AGPS", "AHCYL1", "AKAP8", "AKT2", "AP1M1", "AP3D1", "AP3M1", "APOL2", "APOO", "APP", "ARF5", "ASNA1", "ATG3", "ATP13A1", "ATP1A1", "ATP5J2", "ATP6", "ATP6V0A1", "ATP6V0A2", "AURKA", "BAG6", "BCAT2", "BRCA1", "CAMK2G", "CDIPT", "CDK1", "CDK5", "CHKA", "CLPTM1", "COX2", "CPOX", "CROT", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DDX1", "DDX17", "DDX5", "DHCR24", "DHCR7", "DHX36", "DHX9", "DYNLL1", "EBP", "ERAP1", "ERGIC3", "EXO1", "EXOC1", "EXOC2", "EXOC6", "EXOC8", "FADS2", "FASN", "FECH", "FGFR1OP", "FLNA", "FOXRED1", "GMPS", "GOLGA2", "GOLIM4", "GOLPH3", "GPAM", "GRIPAP1", "GSK3A", "HADHA", "HLA-A", "HLA-C", "HMGB1", "HNRNPD", "HNRNPU", "HOOK2", "IGF2R", "IPO11", "KDELR1", "KDSR", "KHSRP", "KMT2A", "LBR", "LCLAT1", "LDAH", "LMAN1", "LPCAT3", "LSS", "MAVS", "MBOAT7", "MCAT", "MIF", "MORC2", "MSMO1", "MTAP", "MTCH1", "MTCH2", "MTMR6", "MTX1", "MYH10", "MYO5A", "NAMPT", "NAP1L1", "NAPG", "NCAPD3", "NCAPG2", "NCBP1", "NCSTN", "NDC1", "NDUFA11", "NDUFA8", "NDUFB9", "NDUFC2", "NDUFS7", "NMD3", "NONO", "NPC1", "NPC2", "NSUN2", "NT5C3B", "NUP188", "NUP205", "NUP37", "NUP43", "NUP93", "NXN", "OCRL", "OPA3", "OSBPL6", "PCBP1", "PCBP2", "PCID2", "PDE6D", "PEX5", "PIK3C2A", "PLA2G15", "PLBD2", "PLD3", "POFUT1", "PPP1CB", "PPT1", "PQBP1", "PRKDC", "PSAP", "PSPC1", "PTGES2", "PTGES3", "PTGR1", "QKI", "RACK1", "RAN", "RAPGEF2", "RTN3", "RUFY1", "SAMHD1", "SEC13", "SEC16A", "SEC24B", "SEPT6", "SETD2", "SFPQ", "SFXN4", "SHMT1", "SIGMAR1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A26", "SLC25A32", "SLC35B2", "SLC35F2", "SLC39A14", "SLC4A7", "SLC9A6", "SLFN11", "SNX12", "SNX27", "SNX9", "SORT1", "SPTLC1", "SRSF3", "STARD3", "TDRKH", "TECR", "THOC5", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM8A", "TIMM8B", "TMED7", "TNPO1", "TOMM20", "TOMM22", "TPI1", "TRIM25", "TSNAX", "TTC26", "TTC4", "TTLL12", "TYMS", "UBE2O", "UNC119B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "USP7", "VDAC1", "VDAC2", "VPS29", "VPS33B", "XRN2", "ZCCHC3"]} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/advanced/idx2term.json b/protein_atlas_disease_involvement/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..61747197996f0b1d35ab747da50fc57e88820e60 --- /dev/null +++ b/protein_atlas_disease_involvement/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Cataract", "1": "FDA approved drug targets"} \ No newline 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https://git-lfs.github.com/spec/v1 +oid sha256:83145fb6675356ecd38a62830dbfd44c9bcef194f6fa046d9e3d1c22fc8ce8ea +size 88157 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..48f9bd4d62f3cd9091e2c8899b289137741236d0 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Cataract 15 26 2.4058427776610074 0.0161352070670139 7.509708737864078 26.679611650485437 0.6066406061606927 0.4718259290301406 3.570701015264242 3.2395121058789256 1.0572468917106954 0.3422408621391183 1.0 0.4242240140575919 0.0023574925731147 0.0015622461376846 +FDA approved drug targets 29 105 2.283952910954006 0.0223742985289656 24.04854368932039 119.4247572815534 0.6623112070438231 0.5745671660823485 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"results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8461fa9bdf373c44711dba90068ea93788bdd30e --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,35 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Niemann-Pick disease 0.970549305095963 4.123231400214424 3.735940491012002e-05 0.0042499948197943 0.0005885265698643 2 O15118 1 +Metachromatic leukodystrophy 0.8173395102581122 3.3999138725344857 0.0006740708182622 0.0739897581649031 0.0032018363867454 2 P07602 1 +SCID 0.7988075840485395 2.922473729739872 0.0034726291421063 0.3273759270369993 0.013253159423052 3 P00813 1 +Rhizomelic chondrodysplasia punctata 0.7877947798380254 2.8694875720696142 0.0041113748911745 0.3747869958204642 0.015119249599803 3 O00116 1 +Neuronal ceroid lipofuscinosis 0.7428468211450864 2.6495144858359123 0.0080607516554538 0.602535369343564 0.0248358294249118 3 P50897 1 +Cataract 0.5691195329713364 2.4058427776610074 0.0161352070670139 0.8434554820416598 0.0423104936174013 26 Q8WVX9,P48449,Q53H12,O15228,Q01968,P08670,Q6XZF7,O00443,Q15125,Q15800,Q5SRE5,P35579,Q9H078,O00116,Q9H6K4 15 +FDA approved drug targets 0.3788121390769098 2.283952910954006 0.0223742985289656 0.924198535124333 0.0554493485283062 105 P12277,P26358,Q16836,P11802,Q9NRF9,P00390,P05023,P00813,P04818,P39023,P49721,P28074,P05067,P20618,P12532,P09874,Q05655,O95864,Q16850,Q9NR33,Q99720,P09884,P49327,P68371,P07437,Q13423,P98194,P30044,Q07864 29 +Dystonia 0.7383993714924815 1.77116176966197 0.0765338046257995 0.9998857136800886 0.1504285125403645 6 P35270,O60220,Q15043 3 +Fanconi anemia 0.5531281032770647 1.653637895936103 0.0982011080482521 0.9999923703345032 0.1897445138559447 3 P38398,Q9BXW9 2 +Gangliosidosis 0.6263359897102718 1.4976879272468788 0.1342143499518522 0.999999926754036 0.2390693108517367 5 P07602 1 +Mucopolysaccharidosis 0.6187251354183747 1.4614105447047716 0.1439028086196532 0.9999999796937262 0.2523833874252379 5 P15586,P16278 2 +Xeroderma pigmentosum 0.4526803441429638 1.3673672997736184 0.1715102066488238 0.9999999995161212 0.2918233366860585 2 P19447 1 +Cockayne syndrome 0.4526803441429638 1.3673672997736184 0.1715102066488238 0.9999999995161212 0.2918233366860585 2 P19447 1 +Neuropathy 0.3574030743051928 1.2474435789418807 0.2122348959215814 0.999999999998454 0.3506489584791344 51 P00846,O95831,P26358,Q15067,P49773,Q9Y6X9 6 +Ectodermal dysplasia 0.5760613354980347 1.205030815849188 0.22819140584257 0.99999999999985 0.3716260038007569 8 P61586,Q9Y6K9 2 +Palmoplantar keratoderma 0.6075408120137629 1.189549817600104 0.2342233795832413 0.9999999999999388 0.3760769756688664 6 P53634,Q9H4L7 2 +Primary microcephaly 0.5472795957581849 1.1542256518189415 0.2484076684656311 0.9999999999999928 0.3933121417372492 9 Q86XL3,Q8NFH4 2 +Schizophrenia 0.3944407677035186 1.008922627287456 0.3130117425115286 1.0 0.4634199824196657 2 Q9NTZ6 1 +Proto-oncogene 0.3540791395540937 0.9545080840122674 0.3398265192517484 1.0 0.4903825720848015 40 Q03164,O96028,Q15154,Q15022,Q9BZH6,P61586,Q06136,Q9BZE9,P06753,Q92804,Q16204,P31751,O14965,Q96T37 14 +Hypotrichosis 0.4816866208544171 0.6390775574143714 0.5227724789073973 1.0 0.7180248505475095 6 P48449,Q8IWS0 2 +Leukodystrophy 0.3667555226621538 0.57373447793177 0.5661474933679831 1.0 0.7541487225399179 17 P15289,P49770,P54136,P07602,Q13144 5 +Craniosynostosis 0.3525322740814208 0.5526109975690551 0.5805298097251317 1.0 0.7606942334329311 3 Q08209,P16435 2 +Hereditary hemolytic anemia 0.3657171510525345 0.488787306591637 0.6249922854933216 1.0 0.7916568949582073 13 P00813,P00390 2 +Dwarfism 0.2874773792634205 0.4208217168634366 0.6738852723422686 1.0 0.8213398668186285 45 O95831,Q14739,O00116,P09884,Q7RTS9,Q6DKJ4 6 +Spinocerebellar ataxia 0.3791883997177341 0.4106120381770412 0.6813570351389922 1.0 0.8213398668186285 10 O15020,Q8IV08,Q9UBB4,P13639,O14773,Q14671 6 +Glutaricaciduria 0.3298013245033039 0.3035208757003966 0.7614929408531823 1.0 0.8832311651025139 4 Q16134,Q92947,P38117 3 +Cardiomyopathy 0.2946274761872628 0.2861487693344743 0.7747641799144858 1.0 0.8832311651025139 23 P09493 1 +Lissencephaly 0.3629016871431961 0.2651625176529739 0.7908842682274304 1.0 0.8926812532468027 8 P43034,Q9Y320,Q9UPN3,Q00535,Q9BSJ2 5 +Amyotrophic lateral sclerosis 0.3121483636692695 0.2334632460187565 0.8154017064645742 1.0 0.9113313189898182 12 Q99720 1 +Congenital disorder of glycosylation 0.2902341053381307 0.1923078003690432 0.8475011086272757 1.0 0.9333829081651196 18 Q8N511,Q9HC07,Q2TAA5,Q9BV10 4 +Charcot-Marie-Tooth disease 0.2716575986624415 0.187195676639483 0.8515072144664249 1.0 0.9333829081651196 25 O95831 1 +Glycogen storage disease 0.3235399975739423 0.1486982029992072 0.8817917792727756 1.0 0.9573739317818708 8 P35573,P13473 2 +Emery-Dreifuss muscular dystrophy 0.3194168323392939 0.11215983374319 0.9106966761883312 1.0 0.9785378681693448 6 P02545,Q13642,Q8NF91,P50402,Q8WXH0 5 +Epilepsy 0.2203344139221219 0.0333877385001764 0.9733653874719616 1.0 0.999672560106339 59 Q14108,Q6PJG6,Q9Y4G8 3 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a25dd19afa9f11070f6db78d0eaddf0a477fa30c --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Aortic aneurysm", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP9", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ANAPC1", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARPC1B", "ARSA", "ASAH1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATRX", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCKDHA", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BMS1", "BPTF", "BRAT1", "BRCA1", "BRD4", "BRD7", "BRI3BP", "BUB1B", "BUD23", "C12orf57", "C19orf70", "C1QBP", "CAD", "CADM1", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN5", "CARM1", "CARS", "CAST", "CBL", "CCAR1", "CCAR2", "CCDC115", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCNB1", "CCNK", "CCT5", "CDC27", "CDC37", "CDC42", "CDC45", "CDC73", "CDH2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHST14", "CISD2", "CKB", "CKMT1A*", "CLCC1", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CLU", "CNNM4", "CNOT1", "CNOT3", "COA7", "COASY", "COLGALT1", "COMT", "COPA", "COPB2", "COX15", "COX2", "COX4I1", "COX5A", "COX6B1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTH", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DARS", "DARS2", "DAXX", "DBN1", "DBT", "DCPS", "DCTN1", "DDHD2", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJB11", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DOCK7", "DPAGT1", "DPF2", "DPM1", "DSG2", "DSP", "DYM", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "EBP", "ECE1", "ECHS1", "ECT2", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF2S3", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERGIC1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC6B", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM3C", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FASTKD2", "FBXW11", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FSCN1", "FTO", "FUBP1", "FUS", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GCLC", "GCLM", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GLUL", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNB1", "GNPAT", "GNS", "GOLGA5", "GOT1", "GOT2", "GPHN", "GPI", "GPRASP2", "GRB2", "GSK3A", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2I", "GUSB", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HINT1", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B4", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "IGHMBP2", "IKBKG", "ILF3", "ILK", "IMPDH2", "INF2", "INTS1", "INTS8", "IPO7", "IQCB1", "IRF2BPL", "IRS4", "ITGB1", "ITM2B", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KLC2", "KMT2A", "KTN1", "L2HGDH", "LAMC1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRP1", "LRPPRC", "LSS", "LTA4H", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK3", "MARS", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM3AP", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED23", "MED25", "MESD", "MFN2", "MGME1", "MICU1", "MIF", "MIPEP", "MKI67", "MMAB", "MOCS1", "MOGS", "MORC2", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTOR", "MTPAP", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYLK", "MYO5A", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCKIPSD", "NCOR1", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFL", "NEK9", "NHLRC2", "NHP2", "NIPBL", "NME1", "NME2", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NR2F1", "NSD1", "NSD2", "NSD3", "NSDHL", "NSMCE3", "NSUN2", "NT5C2", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIN1", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRPS1", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PYCR1", "PYCR2", "PYGL", "QARS", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB18", "RAB3GAP2", "RAB7A", "RAB8A", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBM10", "RBM12", "RBM15", "RBM28", "RBM6", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF213", "ROCK1", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS28", "RPS29", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "RTN4IP1", "SAMHD1", "SAR1B", "SARS", "SART1", "SATB2", "SBDS", "SCARB2", "SCO1", "SCO2", "SCRIB", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC31A", "SEC61A1", "SEC63", "SELENBP1", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC39A14", "SLC3A2", "SLC9A3R1", "SLC9A6", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SMYD3", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRP54", "SRP72", "SRSF2", "SRSF3", "SSB", "SSR4", "STAG1", "STAG2", "STAMBP", "STARD3", "STAT1", "STAT3", "STMN1", "STRAP", "STRN", "STT3A", "STT3B", "STUB1", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SYNE1", "SYNE2", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TBL2", "TCEA1", "TCF20", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC2", "THOC6", "TIA1", "TIMM17A", "TIMM22", "TIMM50", "TIMM8A", "TIMMDC1", "TJP2", "TK1", "TKFC", "TKT", "TMCO1", "TMEM165", "TMEM199", "TMEM43", "TMEM70", "TMLHE", "TMTC3", "TMX2", "TNPO3", "TNRC6B", "TOE1", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPR", "TPRKB", "TPX2", "TRAPPC11", "TRIM24", "TRIM25", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRRAP", "TSC2", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWNK", "TXLNA", "TYMS", "U2AF1", "UBA1", "UBA5", "UBE2N", "UBQLN4", "UBR1", "UBR5", "UBTF", "UFC1", "UGDH", "UGP2", "UMPS", "UPF3B", "UQCC2", "UQCRB", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP8", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VKORC1L1", "VPS13C", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS53", "VRK1", "WARS", "WASHC4", "WDR1", "WDR11", "WDR26", "WDR34", "WDR36", "WDR5", "WFS1", "WIPI2", "WNK1", "WRAP53", "XPNPEP3", "XPO1", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2"], "leading_proteins": ["ACOX1", "ADA", "AGK", "AGL", "AGPS", "AIFM1", "AKT2", "ALG11", "ALG12", "ANKLE2", "APP", "ARSA", "ASPSCR1", "ATP1A1", "ATP2C1", "ATP6", "ATXN10", "AURKA", 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https://git-lfs.github.com/spec/v1 +oid sha256:cf62d14d627e9f71aa3caf39fc2cf82880dfeeb2fef7d37699457f1cd00e4bed +size 83646 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a21efc17544d95b9c6093af7aba6a32f2d2c09aa --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Receptor 9 36 3.377037613227535 0.0007327102986953 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0337004996412966 0.0102187791156541 0.0793566502209948 0.6751585522787455 +Protease 18 78 2.8958553192737617 0.0037812668817487 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.1027419130690078 6.922830596561845e-05 0.0013081291481222 0.0164637209396585 +Host cell receptor for virus entry 2 14 2.730970566512907 0.0063148111093231 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0179094063189584 0.0075361578498098 0.0793607883255565 0.3340933889960909 +Metalloprotease 7 26 2.5516005067176883 0.0107229391415148 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.2486824788491954 0.0022887430854204 0.0025776990482271 0.0065824357934952 +Muscle protein 3 5 2.364046045104303 0.0180765657389598 2.395631067961165 5.79126213592233 0.1338245975855889 0.4297267356278353 1.4112173151187923 1.0428309859537837 1.1380106971522683 0.3003044609278026 1.0 0.1677870330809631 0.0009487109772629 0.0118865434534573 +Carboxypeptidase 3 6 2.306572508349509 0.0210786636169768 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 0.0023758658868836 1.0100053103379697e-05 0.0003603697136508 0.0005289198821125 +Aminopeptidase 3 12 2.251999734238499 0.0243222888105438 2.8567961165048543 11.50728155339806 0.7720047733796322 0.3726630495484194 1.6314200816170448 0.9938868429806352 0.9329115225234256 0.2734153397335634 0.0981765691424607 0.0170518298819148 0.0014106533758772 0.017002584405276 +Hydrolase 40 368 2.0009600890812917 0.0453966911083287 64.97087378640776 381.1650485436893 -0.1426199141915242 0.6734352746482181 21.484790877323487 36.07841973574662 1.159823788317903 0.3763062344575927 0.0010123971744463 0.0006051724693403 0.0001840016625693 0.0095842886082654 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f71ed8a7ec064a1c4f4b849b767661c54f5248d9 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3024, + "annotations_size": 96, + "title": "Average number of proteins per term", + "value": 37.895833333333336 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..75b6c570cad339110e823ad4091a2d3eca8548b7 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..48ac60b9f44294fcbbd440e3d6a872abe43b62c0 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,40 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Monooxygenase 0.868630046326939 3.649487503515831 0.0002627640215062 0.0249130776228482 0.0025225346064601 2 Q16850 1 +Receptor 0.6449299337086009 3.377037613227535 0.0007327102986953 0.0679473465364004 0.0058616823895629 36 Q8WTV0,Q99523,Q14108,P24390,Q99720,Q14739,Q9NS69,P10586,O15118 9 +Protease 0.4426011769051511 2.8958553192737617 0.0037812668817487 0.3048931183089322 0.022358644582722 78 P48147,O75976,O15484,P50579,Q9HB40,Q9UIQ6,P42892,Q5JRX3,Q99797,P42785,Q9NZ08,P10619,P53634,Q99538,P28074,P55786,Q9H3G5,O75844 18 +Host cell receptor for virus entry 0.7478985184105628 2.730970566512907 0.0063148111093231 0.455639763160893 0.031906414026054 14 Q8WTV0,Q14108 2 +Metalloprotease 0.5892331547286933 2.5516005067176883 0.0107229391415148 0.6447597791910575 0.0457077668276539 26 Q9UIQ6,P42892,Q5JRX3,Q99797,Q9NZ08,P55786,O75844 7 +DNA-directed DNA polymerase 0.7930463576158889 2.5502129709371055 0.0107657131708478 0.6462312916097817 0.0457077668276539 4 Q9NRG0,P09884,P28340 3 +Voltage-gated channel 0.6336863004632761 2.4352325804956534 0.0148822205034764 0.7629373671377196 0.0566708716207392 2 O00299 1 +Cytokine 0.7659082772670704 2.4240531008010167 0.0153483610639502 0.7734675724381702 0.0566708716207392 4 P14174 1 +Muscle protein 0.8149853264447685 2.364046045104303 0.0180765657389598 0.8264390620291515 0.064272233738524 5 P06753,P09493,P67936 3 +Porin 0.7458752948130682 2.3297007696871472 0.0198219718436547 0.8536891766926912 0.067961046321102 4 P45880 1 +Carboxypeptidase 0.8642450548098355 2.306572508349509 0.0210786636169768 0.8706434978965224 0.0697776450768889 6 P42785,Q9HB40,P10619 3 +Aminopeptidase 0.6791513484858243 2.251999734238499 0.0243222888105438 0.9059382935515332 0.0771033265148221 12 Q9NZ08,Q9UIQ6,P55786 3 +Serine protease inhibitor 0.7063099893582013 2.140304227336089 0.0323301885813673 0.9573606594558108 0.0912852383473902 4 P05067 1 +Chloride channel 0.6338960609069825 2.09072944719075 0.0365523237233356 0.9719778904915936 0.1002578022125776 3 O00299,Q96S66 2 +Hydrolase 0.2785859380831396 2.0009600890812913 0.0453966911083287 0.9884388296905682 0.1146863775368306 368 P15586,Q7Z478,P50579,Q9NUJ1,Q8NHP8,Q5TFE4,Q8NCC3,P07099,P42785,Q969T7,O43681,Q9NPH0,Q9H773,P49773,P55786,Q9H6V9,O94919,Q9HB40,P00813,P61586,Q15165,Q5JRX3,P28074,O60502,P27695,P48147,Q14566,P42892,Q9NZ08,P10619,Q96DE0,Q9H3G5,O75844,Q16775,Q8IV08,Q9UIQ6,Q9UQ84,Q9UMR5,P16278,P10586 40 +Methyltransferase 0.4611051313621137 1.9513034026839835 0.0510209645441479 0.9934440542558304 0.1255900665702103 40 Q03164,Q9BZ95,O96028,Q9BV44,P26358,Q96KQ7,Q99873,Q86X55,Q7Z2T5,P04818,Q08J23,Q8N6R0,Q7Z4G4,O60725,Q5T280,Q9BV86 16 +Oxidoreductase 0.3061016164157133 1.505385185734999 0.1322250755416321 0.9999987779717142 0.2884910739090155 158 Q8N4Q0,Q9BU89,P35270,P09601,Q14914,O75251,Q9UHG3,P00390,O95831,Q15392,Q8NBX0,P09622,P36551,Q15800,P30519,Q8N8N7,Q96CU9,Q9NVH6,O95864,Q16850,P40939,Q6NUM9,Q99536,Q9NZ01,Q9H6W3,O14880,P49327,Q5VT66,P23378,Q06136,Q15067,P30837,P30044,Q14739,O15254,Q6DKJ4 36 +Heparin-binding 0.6417810746541306 1.4277901742394057 0.1533522618330456 0.9999998853261908 0.3132301518291995 7 P05067 1 +Transferase 0.2580817937994766 1.1796083270967588 0.2381560295010087 0.9999999999954382 0.4661096292358597 328 Q03164,P12277,Q9BWD1,P52788,Q8NCC3,Q86UY6,Q9H9Y6,Q9NT62,Q13126,Q13555,P34896,P19474,O60725,Q53H12,P34897,P11182,Q8NFW8,P43490,Q7Z6E9,P30876,P49792,Q07864,O00116,Q7Z4G4,Q9BV44,Q9BZ95,Q6P1A2,P26358,P29401,Q16836,O14929,P11802,Q7LGA3,O15382,Q08J23,P55263,Q9BV10,P09874,P78527,P40939,P09884,Q5SY16,Q9UKG9,O14880,Q8IWV8,Q6UWP7,O14976,O96028,Q9HCL2,Q86X55,P35790,O15269,O14965,Q00535,Q2TAA5,Q10472,P04818,P12532,Q9NRG0,P31751,O15111,Q96N66,P04183,Q13557,P52789,O95747,O14735,Q5T280,Q9UIG0,Q9BV86,Q9NPF4,Q13057,Q9C0C9,Q96KQ7,Q96KB5,Q7Z2T5,Q99943,Q9HA64,Q05655,P35573,Q8N6R0,Q8NCH0,Q99570,Q9H488,Q8IVS2,P49327,P28340,Q99873 88 +Acyltransferase 0.3808419540861529 1.1743813199925213 0.2402423240252957 0.999999999996494 0.4661096292358597 38 Q6P1A2,Q9HCL2,Q9BWD1,P11182,Q9NPF4,Q8NCC3,O15269,Q6UWP7,Q96N66,Q9UKG9 10 +Myosin 0.5176799696042069 1.0991386230918634 0.2717076053756586 0.9999999999999396 0.4921496248313816 10 Q9Y4I1,P35580,P60660 3 +Endonuclease 0.4250314792999342 0.9747909103142548 0.3296639868468896 1.0 0.5632249188154855 18 P27695,Q9ULX3,O94919,Q9UQ84 4 +Translocase 0.4172008638237838 0.9652596120651784 0.3344147955466945 1.0 0.5632249188154855 19 P08574,P00403,P05023,Q13423,Q9HD20,P08183,O75251 7 +Protease inhibitor 0.4867873433803715 0.714430046006278 0.4749612983354712 1.0 0.7237505498445275 7 P05067 1 +Glycosyltransferase 0.3338190131983763 0.6781185858884134 0.4976965072991008 1.0 0.7465447609486513 31 P09874,Q2TAA5,Q10472,P35573,P43490,Q13126,Q9BV10 7 +Developmental protein 0.2714515574305437 0.613298995082861 0.5396786577332944 1.0 0.7732709125730786 78 Q00839,O96005,Q13555,Q9UPW6,Q9H2U1,Q99523,P43034,O60879,Q99598,Q96PU8,Q13045,Q7L576,P31751,Q6UWP7,Q6DKJ4,Q68CQ4,Q9Y4G8,Q8IUH3 18 +Exonuclease 0.3467936026210794 0.540125363851168 0.5891105799326954 1.0 0.8316855246108641 20 Q8IV08,Q9UQ84 2 +Signal transduction inhibitor 0.2958305757776391 0.4425670947506361 0.6580788898973737 1.0 0.9025081918592556 2 P49840 1 +Isomerase 0.2661679804447295 0.3858209662554939 0.699629266474386 1.0 0.9088586836566138 54 P48449,P14174,Q15125,Q13427,Q15185 5 +Serine/threonine-protein kinase 0.2657351892323175 0.3234581307745496 0.7463483114491876 1.0 0.9223555434835568 51 O14976,Q05655,Q13557,Q13555,Q96KB5,P78527,P31751,O14965,O15111,O95747,Q00535 11 +Guanine-nucleotide releasing factor 0.3287864865218315 0.3194123076797537 0.7494138790803899 1.0 0.9223555434835568 14 P80303,Q9Y4G8 2 +DNA-binding 0.2138460859789621 0.2337584906567284 0.8151724764525103 1.0 0.9436732484675988 222 O96028,P26358,Q9H2U1,Q96AE4,Q14103,Q9NYF8,Q9NRF9,Q9UFW8,O95831,Q96ME7,Q9UPW6,Q14807,P46063,P19474,Q66K74,Q00839,Q9H4L7,P27695,P09874,Q9NRG0,Q14566,Q9NR33,P78527,Q99598,Q06481,Q15366,P09884,Q9NUD5,Q9UHX1,O43823,P28340,O75531,Q02818,Q15365,Q9UQ84,Q92766,Q08211,P80303,P09429,Q14739,Q92945,Q9UGU0,P16989 43 +Kinase 0.2407988200846558 0.2328419164039778 0.8158841627376114 1.0 0.9436732484675988 96 O14976,P35790,O14965,Q00535,Q13057,Q13555,Q96KB5,P55263,Q9HA64,P12532,Q05655,P78527,P31751,O15111,Q5SY16,P04183,Q13557,P52789,O95747,Q9UIG0 20 +Nuclease 0.2607050378310131 0.1783621555677069 0.85843856818634 1.0 0.9633744874120488 37 Q8IV08,O94919,Q9UQ84 3 +Glycosidase 0.2763191674953823 0.1278582301955366 0.8982611671365666 1.0 0.9819546178029632 17 P06280,P08236,P35573,P16278,O60502 5 +Lyase 0.2423046947644911 0.0787717379458939 0.9372141840282016 1.0 0.988709468864916 40 O14880,P49327,P40939,P22830,P32929 5 +Nucleotidyltransferase 0.2362380844695289 0.0278860879446501 0.9777530043414708 1.0 1.0 24 Q13057,P28340,P30876,Q9NRG0,Q8NFW8,P09884,Q9H9Y6 7 +Thiol protease 0.2329892696543197 0.0205754189761529 0.9835843491301764 1.0 1.0 25 O15484,Q13867,P53634,Q99538,Q93009,Q9Y5K5,Q86UV5 7 +Actin capping 0.2396486161701606 0.0076068253546057 0.9939306900251076 1.0 1.0 7 Q01082,O15020 2 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..026bd4e259affb7c51d20f7ffe9c8dc513d3f9e7 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Potassium channel", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALKBH5", "ANKHD1", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APLP2", "APP", "APRT", "AQR", "ARFGAP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATF7IP", "ATG3", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATRX", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BANF1", "BAP18", "BAZ1B", "BAZ2A", "BCAT2", "BCKDHA", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "CAD", "CADM1", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC47", "CCDC51", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CEP55", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLU", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "COASY", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CROT", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTH", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXADR", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTD", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DRG1", "DRG2", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ERP44", "ESD", "ESPL1", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "F11R", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM208A", "FAM3C", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FOXK2", "FOXRED1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPAM", "GPD2", "GPHN", "GPI", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFRD1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "INA", "INF2", "INTS11", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISG20L2", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "KARS", "KAT7", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAPK1", "MAPK3", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST3", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOCS1", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPHOSPH10", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MTA1", "MTA2", "MTAP", "MTERF3", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP3", "NCL", "NCOA5", "NCOR1", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEK9", "NELFA", "NELFCD", "NES", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUP153", "NUP98", "NUSAP1", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PCYOX1L", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM7", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB2", "PHF5A", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PI4KB", "PIGK", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP3CA", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKCD", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS1", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB11B", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD50", "RALA", "RALGAPB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIOX1", "RIPK1", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP14", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RSF1", "RTCA", "RTCB", "RTF1", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SCAF1", "SCAF4", "SCAF8", "SCARB1", "SCARB2", "SCCPDH", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC14L2", "SEC61A1", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAMBP", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SVIL", "SYNCRIP", "SYNE1", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKFC", "TKT", "TMCO1", "TMLHE", "TMOD3", "TMTC3", "TMX3", "TNRC6B", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSN", "TSNAX", "TSTA3", "TTF2", "TTK", "TUFM", "TWF1", "TWF2", "TWNK", "TXNDC12", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBLCP1", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCRFS1", "UROD", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP3", "UTRN", "UXS1", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS4B", "VRK1", "WARS", "WASF2", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR48", "WDR5", "WNK1", "WRAP53", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF3", "ZADH2", "ZC3H14", "ZC3H7A", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCRB1", "ZFR", "ZMPSTE24", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF638", "ZRANB2"], "leading_proteins": ["ABCB1", "ABHD10", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ADA", "ADK", "AGK", "AGL", "AGPAT1", "AGPS", "AIFM1", "AKAP8", "AKT2", "ALDH1B1", "ALG11", "ALG12", "APEX1", "APLP2", "APP", "ASNA1", "ATG3", "ATP13A1", "ATP1A1", "AURKA", "BANF1", "BAZ1B", "BCAT2", "BCLAF1", "BLMH", "CAMK2D", "CAMK2G", "CAPN5", "CARM1", "CDIPT", "CDK4", "CDK5", "CGGBP1", "CHKA", "CHRAC1", "CHST14", "CHUK", "CKB", "CKMT1A*", "CLCC1", "CLIC1", "CLPTM1", "CMAS", "COASY", "COX2", "CPD", "CPOX", "CPVL", "CROT", "CTH", "CTSA", "CTSC", "CYC1", "CYFIP1", "CYP51A1", "DBT", "DCTPP1", "DHCR24", "DHX29", "DHX36", "DHX9", "DIAPH2", "DIEXF", 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2.460138488635829e-06 1.3778884012714958e-06 0.0001135037001612 +Transporters 59 342 3.771674531518289 0.0001621556771418 108.9004854368932 367.3009708737864 1.469396346451591 0.4764419032567517 40.40141182476491 35.10022679965902 2.352674986871393 0.4490473364946538 0.0004208511408673 1.6310152096496998e-06 9.586494942999e-06 0.0006646816441017 +Metabolic proteins 197 834 3.2125604590682317 0.0013155745575592 167.96116504854368 885.0898058252427 0.3517504365488901 0.4992811695371688 49.08590099318301 81.73901275864796 1.4937513760737942 0.4046478208580187 0.0001011325526231 0.0001633763622332 2.3018590891488844e-05 7.84507429492491e-06 +Predicted secreted proteins 11 47 2.773378420632435 0.0055477566161152 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0099079782805238 0.0002507561403829 0.0290807952078154 0.1605096404151789 +FDA approved drug targets 29 105 2.283952910954006 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--git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4a09eedef243c1cb2e710d8a28fd89d31057155d --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C262/C262_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0bd37dec758170393aa3d7daaab77234bc606a3f --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,13 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.4398952250263747 6.433956586750529 1.2432438241767048e-10 2.6108120485252042e-09 1.3054060258855402e-09 501 Q567V2,Q99595,Q8WTV0,Q14108,Q9NR77,P24390,Q8NCC3,Q8IXU6,Q6NT16,Q9NS69,Q70HW3,Q93050,Q9H6V9,O95831,O60830,Q13555,Q5VW38,Q9BQE5,Q15392,O43772,Q8NBX0,Q9HD20,P30519,O60725,P05067,P09493,O15118,Q92896,Q8N511,Q99805,Q99523,Q16850,P42892,Q99720,O15260,O00461,Q9H061,O75844,Q9Y2W6,P00846,Q8IV08,Q9UIQ6,Q13423,P08183,Q14739,P10586,Q6P1A2,Q9HD45,Q9Y6C9,Q9Y282,P09601,Q7RTS9,Q9Y584,Q92542,Q8IZ83,Q15043,P49815,O43169,O94919,Q9BUB7,Q5KU26,Q15800,P41440,Q8NC54,Q9UDW1,Q9BV10,O43493,Q86Y39,Q8ND04,Q06481,Q6NUM9,Q9UBX3,Q9UH99,O14880,Q86XL3,Q9HC07,P49257,O60637,Q6UW68,Q8IWV8,P53634,Q6UWP7,Q9BTX1,Q9Y619,P00403,P10321,P11717,Q8TB61,Q9HCL2,Q9H2U1,Q9BUR5,Q14849,Q15125,O95298,O15269,P43307,Q13505,Q9NZJ7,Q8N201,Q2TAA5,Q10472,P57088,Q86YN1,Q5SNT2,P04439,O96005,O95197,O75976,Q9Y487,P13473,Q96N66,Q9Y3B3,Q9NZ01,Q96A26,Q13557 115 +Transporters 0.3510099086049501 3.771674531518289 0.0001621556771418 0.0033997530493301 0.0008513173049946 342 P00403,P11717,Q8TB61,Q8WTV0,Q9BUR5,Q14108,Q9Y6C9,Q9NR77,P24390,Q14849,O43681,Q8IXU6,Q6NT16,Q5SRE5,Q9NZJ7,Q70HW3,Q93050,P55735,Q15043,Q13555,Q5VW38,Q9UI26,Q9BUB7,O43772,P57088,P07602,Q9HD20,P41440,P05067,Q09161,O15118,Q8N511,Q99805,P04439,O43865,O96005,Q8IYI6,Q99523,Q99720,O15260,Q96KP1,P13473,Q96N66,Q9H061,P61916,Q9UBX3,Q9UH99,Q9UKG9,O75844,Q9HC07,P49257,P45880,O60637,Q6UW68,Q8NFH4,P08183,Q9BTX1,Q9Y619,Q9H2D1 59 +Metabolic proteins 0.2912030342295812 3.2125604590682313 0.0013155745575592 0.0272666215074479 0.0055254131417489 834 Q03164,Q8N4Q0,P17812,Q8WTV0,P12277,P43034,Q9BWD1,P52788,Q8NCC3,P07099,Q86UY6,Q969T7,Q8TBC4,Q14914,Q92947,Q9NPH0,P22830,Q9NRF9,Q9H9Y6,Q9UHG3,P55786,Q13126,Q70HW3,Q93050,P55735,Q86UV5,P14174,Q13555,P05023,P06280,P15289,P00813,P34896,Q15392,Q15165,O43772,Q8NBX0,P07602,P09622,P50336,P30519,O60725,O15118,P48449,Q53H12,O43808,P20674,P48147,O43865,O43488,O43924,P00367,P34897,Q16850,P11182,Q8NFW8,P10619,Q8N1F7,Q13427,P43490,Q9UBQ0,O75844,Q7Z6E9,P00846,Q16775,Q8IV08,P08574,Q709F0,P08243,P14854,P30876,P34913,O00462,Q13423,P54136,P30837,Q9UMR5,P16278,P98194,O00116,P08183,Q14739,P49792,Q07864,Q9H2D1,Q93009,O15254,P10586,P15586,Q6P1A2,P26358,P35270,P09601,Q5SRE5,Q9H773,Q15043,Q7LGA3,O15382,Q15800,P55263,P41440,P51970,O60502,Q15185,Q9UDW1,Q9BW71,Q9BV10,P09874,Q86Y39,P78527,P50897,P40939,P31930,P09884,Q5SY16,Q9UBX3,Q9UKG9,O14880,Q8NFH4,Q8IWV8,Q15067,P53634,Q6UWP7,Q9BTX1,Q9Y619,Q10713,O14976,O96028,P00403,Q8TB61,Q9HCL2,Q14849,Q86X55,Q15125,P35790,O95298,O15269,O14965,Q00535,Q2TAA5,Q13526,Q10472,P04818,Q86YN1,P32929,P12532,P32321,Q9Y487,Q9NR33,P31751,O15111,Q96N66,Q9NZ01,P04183,Q13557,P23378,P52789,P30044,O95747,O14735,O14949,Q92621,Q99538,O75251,P00390,P67812,Q13057,Q9C0C9,Q96KQ7,Q96KB5,Q7Z2T5,P36551,Q99943,Q9HA64,Q9NVH6,Q9Y6M9,Q05655,O95864,P08236,P22695,A0AVT1,P35573,P53985,Q8N6R0,Q8NCH0,Q99570,Q8IVS2,P49327,Q01968,P28340,P56134,Q04760,Q06136,Q8NFH3,Q99873,Q9UBM7,Q9Y217 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153 +Potential drug targets 0.253736338264962 1.085566102798993 0.2776710034780325 0.9989199694708384 0.530099188458062 464 P15586,O96028,P00403,Q14108,Q15125,Q99797,P07099,P35270,P09601,O15269,Q5SRE5,P22830,Q13126,Q70HW3,Q15043,Q00535,P14174,Q13555,Q9BUB7,Q2TAA5,P61586,Q15392,O43772,P07602,P09622,Q08J23,Q15800,P55263,O15118,Q9BV10,P48449,P32929,Q8N511,P04439,Q99523,P11182,P42892,P78527,P50897,P40939,P10619,P31751,P13473,O15111,Q96N66,Q9H061,P61916,O75844,Q8IV08,Q9HC07,P49257,Q8NFH4,Q15067,P53634,P16278,O00116,Q14739,Q9Y619,Q10713,Q9H2D1,P10586,Q6DKJ4 62 +Candidate cardiovascular disease genes 0.4954117255873892 0.9817646444125604 0.3262158098820753 0.999749425343766 0.5609174851279042 10 Q15165 1 +CD markers 0.3697573634803923 0.5260391176601968 0.5988610282518008 0.9999999953313428 0.8249453936329377 14 P11717,P08183 2 +Human disease related genes 0.2156611690148081 0.4337369533669752 0.6644794688676559 0.9999999998903266 0.8249453936329377 886 Q14108,Q9NR77,P07099,P22830,P49773,Q70HW3,O95831,P14174,Q13555,Q9BQE5,P00813,P61586,Q15392,O43772,P07602,P09622,P05067,P09493,O15118,P48449,Q8N511,Q9BZH6,O43924,P11182,P42892,Q99720,P10619,Q9H061,P61916,Q9Y4G8,O75844,P00846,Q8IV08,O75531,Q13423,P16278,Q6PJG6,O00116,P08183,Q14739,P15586,P26358,P35270,P09601,O60220,Q7RTS9,Q9Y584,Q92542,Q15043,P49815,Q9Y6K9,P08670,Q6XZF7,Q9Y4I1,Q9BUB7,O75530,P06753,Q08J23,Q15800,P55263,Q9BV10,O75569,Q86Y39,Q8IYI6,P78527,P50897,P40939,Q16204,P09884,O60828,Q9UBX3,Q9Y6X9,Q86XL3,Q9Y4W2,Q9HC07,P49257,Q86XI2,P50542,Q8NFH4,Q15067,P53634,Q9Y619,Q9UGU0,Q10713,Q69YQ0,O96028,P00403,P10321,Q15125,Q99797,P42695,O15269,Q8N201,Q6PGP7,Q00535,P07737,O00170,P98175,Q9UPW6,Q2TAA5,Q00839,P32929,P04439,Q9Y487,P31751,P13473,O15111,Q96N66,Q9UHX1,Q9NZ01,P68371,P23378,Q14CX7,Q9H7D7,O75503,Q9UIG0,O15484,O14949,Q92621,Q96NT0,Q9NPF4,P35579,O75251,P35250,Q07020,Q13057,Q9UEY8,Q14807,P36551,Q6P4A7,Q96CU9,Q9BTW9,Q9H4L7,Q9NVH6,Q9Y6M9,Q05655,O75718,O14617,P08236,P22695,P35573,P53985,Q9BU61 143 +RAS pathway related proteins 0.2696090794477721 0.1765743350330178 0.8598427549635288 1.0 0.9511650652697584 25 P61586,Q96KP1,Q9Y6K9,P31751 4 +RNA polymerase related proteins 0.3069794077443065 0.1756385479576289 0.860577916196448 1.0 0.9511650652697584 11 Q9H9Y6,P62875,P30876,P62487 4 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ec163dc0a465754a3a61b8e3dc41a0d449d234a2 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Nuclear receptors", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG14", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMC8", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATF7IP", "ATG3", "ATG7", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATRX", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCKDHA", "BCL2L13", "BCLAF1", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRI3BP", "BRIX1", "BRK1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf57", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C2orf49", "C5orf15", "C5orf51", "C8orf33", "C9orf64", "CAB39", "CACUL1", "CACYBP", "CAD", "CADM1", "CALD1", "CALM3", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC138", "CCDC22", "CCDC47", "CCDC51", "CCDC6", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CENPH", "CENPV", "CEP44", "CEP55", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA7", "COASY", "COG3", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTH", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPAGT1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF2S3", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXW11", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GOT2", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPR107", "GPR180", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GXYLT1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HAT1", "HAUS1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFRD1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPCAT3", "LPGAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRC8C", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZIC", "LZTS2", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED24", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MFSD5", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS12", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFR1L", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYLK", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NEK9", "NELFA", "NELFCD", "NEMF", "NENF", "NES", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSRP1", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT12", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "ODR4", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD1", "SCFD2", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNRPF", "SNU13", "SNW1", "SNX1", "SNX12", "SNX17", "SNX2", "SNX27", "SNX3", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THEM6", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLCD1", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED7", "TMED9", "TMEM115", "TMEM126A", "TMEM161A", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM70", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TNRC6B", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", 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"WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "WNK1", "WRAP53", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZWILCH", "ZYG11B", "ZYX"], "leading_proteins": ["ABCB1", "ABHD10", "ACAD11", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ADA", "ADD3", "ADK", "AGK", "AGL", "AGPAT1", "AGPS", "AHCYL1", "AIFM1", "AIP", "AKR7A2", "AKT2", "ALDH16A1", "ALDH1B1", "ALG11", "ALG12", "ANKLE2", "AP3D1", "APLP2", "APOL2", "APOO", "APP", "ARSA", "ASNA1", "ASNS", "ATP13A1", "ATP1A1", "ATP2C1", "ATP5J2", 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Q15417,Q69YQ0,P17812,O75718,O95425,P42694,P06753,Q6WCQ1,P35580,P35579,Q9BTX1,P09493,P67936 13 +Cell Junctions 0.2796840072505257 0.368017690098362 0.7128600436688908 1.0 1.0 46 Q9NV06,Q13557,Q13555,Q8WUW1,Q5KU26,Q15369,Q66K74,P43490,Q00535 9 +Cytokinetic bridge 0.2810535988583226 0.2382145316587145 0.8117147068644985 1.0 1.0 25 O94915,P68371,P07437,O43663,Q9BUF5,P60953,Q6IBW4,Q96QE3 8 +Intermediate filaments 0.2633600722939712 0.1943229858958063 0.8459229885283335 1.0 1.0 33 P07197,Q9C0D3,P08670,Q5SY16,O75718,O75832,Q86YN1,Q9NU22 8 +Centrosome 0.242861918855533 0.1825783032894685 0.8551289096330752 1.0 1.0 64 P43034,Q8TBC4,O14965,Q5T4S7,Q9Y3D8,Q9BRT9,O75934,Q96CS2,P28074,Q3B7T1,P39687,O95684,Q9H488,Q9Y2W6,Q9NV06,Q69YU5,O75330,P41223,P52789,Q2NKX8,Q96ER9 21 +Microtubules 0.2360495172544753 0.0773149044965178 0.9383730343242024 1.0 1.0 48 O94915,O60830,Q01968,Q9BZH6,P68371,P07437,P34897,O43663,Q02818,P31689,Q9BUF5,P55209,P60953,Q709C8,Q99570,P61163,Q9NV70 17 +Focal adhesion sites 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0000000000000000000000000000000000000000..3d8397ac8d447a62dc9827e66fb8009166e2c100 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", 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"CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHID1", "CHKA", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLU", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA7", "COG3", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COTL1", "COX15", "COX4I1", "COX5B", "COX6B1", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRKL", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDHD2", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DOLPP1", "DPF2", "DPH5", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DRG1", "DRG2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "EBP", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOC", "ELP1", "ELP2", "ELP3", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPPK1", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERI1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC1", "EXOC2", "EXOC3", "EXOC6", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM3C", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXW11", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FIS1", "FKBP10", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FOXK2", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GIGYF2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLUL", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNG12", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GPAM", "GPATCH8", "GPD2", "GPHN", "GPI", "GPR107", "GPR180", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS1", "HAUS3", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXIM1", "HGH1", "HGS", "HIBCH", "HINT1", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMGN4", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSF1", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFRD1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IGHMBP2", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INA", "INF2", "INTS1", "INTS10", "INTS11", "INTS3", "INTS4", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "ISCU", "ISG20L2", "ISOC1", "IST1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM4", "LSM6", "LSM7", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZIC", "LZTS2", "MACF1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP2K3", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED21", "MED23", "MED25", "MESD", "METAP1", "METAP2", "METTL13", "MFAP1", "MFN1", "MFN2", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORF4L1", "MOV10", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL42", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL50", "MRPL51", "MRPL53", "MRPL58", "MRPL9", "MRPS10", "MRPS15", "MRPS16", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS6", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTERF3", "MTFR1L", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYLK", "MYO1B", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCAPH2", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFC2", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEFL", "NEFM", "NELFA", "NELFCD", "NEMF", "NES", "NFS1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NLRX1", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NR2F1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSD3", "NSDHL", "NSF", "NSFL1C", "NSRP1", "NSUN2", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NUSAP1", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "ODR4", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARG", "PARK7", "PARN", "PARP1", "PATL1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1L", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PDZD8", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX11B", "PEX14", "PEX19", "PEX3", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PI4KB", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN1", "PIN4", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIL1", "PPIL4", "PPM1G", "PPM1L", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP3CA", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAR1A", "PRKCD", "PRKCSH", "PRKD3", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF39", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PUS1", "PWP1", "PWP2", "PXN", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB11B", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD18", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP6", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM6", "RBM8A", "RBMX", "RBMXL1", "RCC1", "RCL1", "RCN1", "RCN2", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPUSD3", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A11", "SAAL1", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCFD2", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT6", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIN3A", "SIRT2", "SKA1", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC41A3", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMAP1", "SMAP2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5L1", "SPC24", "SPCS2", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOM", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SVIL", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TATDN1", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCC", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8A", "TIMMDC1", "TJP1", "TJP2", "TKFC", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM115", "TMEM126A", "TMEM161A", "TMEM165", "TMEM167A", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM70", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC3", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPYL1", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC27", "TTC37", "TTC38", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TWISTNB", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "U2AF1", "U2AF2", "U2SURP", "UACA", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE3C", "UBE4A", "UBLCP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF2", "UPF3B", "UQCC2", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP24", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13C", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4B", "VPS53", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WASF2", "WASHC4", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR34", "WDR36", "WDR41", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR74", "WDR77", "WDR82", "WIPI2", "WIZ", "WNK1", "WRAP53", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM1", "ZMYM2", "ZMYM3", "ZMYM4", "ZMYND8", "ZNF207", "ZNF280C", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYG11B", "ZYX"], "leading_proteins": ["ABCB1", "ACTR1A", "AGPAT1", "AK6", "AKT2", "ALG12", "ANKLE2", "ANP32A", "APLP2", "APP", "ASCC2", "ASPSCR1", "ATAD5", "ATP13A1", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "AURKA", "BCAS2", "BRK1", "BUD31", "C12orf73", "C1orf123", "C5orf15", "CALU", "CAMK2D", "CAMK2G", "CCDC51", "CDC42", "CDIPT", "CDK5", "CHKA", "CLPTM1", "CLUH", "CNN3", "COLEC12", "CPD", "CPVL", "CROT", "CRTAP", "CTPS1", "CTSA", "CTSC", "CUTA", "CYB5B", "CYB5D2", "CYFIP2", "CYP51A1", "DCAF13", "DHCR7", "DIAPH2", "DNAJA1", "DNMBP", "DOLPP1", "DYM", "EBP", "EDRF1", "EIF2B2", "ELOC", "ENDOD1", "ERCC6L", "EXOC1", "EXOC2", "FAM98A", "FGFR1OP", "FLII", "FRYL", "GAK", "GINS4", "GLB1", "GLG1", "GNL1", "GOLIM4", "GPR107", "GRIPAP1", "GTPBP1", "HAUS1", "HEBP1", "HELZ", "HK2", "HLA-A", "HMMR", "HMOX1", "HMOX2", "HOOK2", "IGF2R", "KDELR1", "KIAA0319L", "KIF18B", "LAMC1", "LAS1L", "LBR", "LCLAT1", "LMAN1", "LRWD1", "MANF", "MAP1S", "MDN1", "MPRIP", "MSMO1", "MYH10", "MYH9", "MYO5A", "NAA25", "NAA40", "NAMPT", "NAP1L1", "NCAPH2", "NDC1", "NEFM", "NOB1", "NOL9", "NPC1", "NUCB1", "NUCB2", "OCRL", "PAFAH1B1", "PEX5", "PIK3R4", "PLA2G15", "PLD3", "POFUT1", "PPT1", "PPT2", "PRC1", "PRCP", "PRKCD", "PSAP", "PSMB5", "PSMD10", "PTGR2", "PTPRF", "RANBP2", "RCN2", "RFC2", "RPL14", "RPL17", "RPL18", "RPL27A", "RPL30", "RPL32", "RPL34", "RPL4", "RPL5", "RPL8", "RPS12", "RPS5", "RPS6", "RTN3", "RUFY1", "SCARB1", "SCCPDH", "SCPEP1", "SEC11A", "SEC13", "SEC16A", "SHMT2", "SLC18B1", "SLC35B2", "SLC35F2", "SLC39A14", "SORT1", "SPECC1L", "SPTLC1", "SSR1", "STARD3", "SUN2", "SURF4", "SVIL", "SYNE2", "TDRKH", "TECR", "TGOLN2", "TIMM17B", "TM9SF3", "TMEM165", "TMEM201", "TMEM205", "TMEM87A", "TPM1", "TPM3", "TPM4", "TRA2A", "TSNAX", "TSPAN3", "TUBB", "TUBB4B", "TUBB6", "UBA3", "UBR4", "VIM", "VPS13C", "WDR11", "ZADH2", "ZC3HC1", "ZCCHC3", "ZYG11B"]} \ No newline at end of file