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  1. interpro_active_site/advanced/idx2term.json +1 -0
  2. interpro_active_site/basic/idx2term.json +1 -0
  3. interpro_active_site/consensus.joblib +3 -0
  4. interpro_active_site/df_merge.tsv +1 -0
  5. interpro_active_site/metrics.json +7 -0
  6. interpro_active_site/paths.json +1 -0
  7. interpro_active_site/result.tsv +1 -0
  8. interpro_active_site/selections.json +1 -0
  9. interpro_binding_site/advanced/idx2term.json +1 -0
  10. interpro_binding_site/basic/idx2term.json +1 -0
  11. interpro_binding_site/basic/plot_0.png +3 -0
  12. interpro_binding_site/consensus.joblib +3 -0
  13. interpro_binding_site/df_merge.tsv +2 -0
  14. interpro_binding_site/metrics.json +7 -0
  15. interpro_binding_site/paths.json +1 -0
  16. interpro_binding_site/result.tsv +5 -0
  17. interpro_binding_site/selections.json +1 -0
  18. interpro_conserved_site/advanced/idx2term.json +1 -0
  19. interpro_conserved_site/basic/idx2term.json +1 -0
  20. interpro_conserved_site/basic/plot_0.png +3 -0
  21. interpro_conserved_site/basic/plot_1.png +3 -0
  22. interpro_conserved_site/consensus.joblib +3 -0
  23. interpro_conserved_site/df_merge.tsv +1 -0
  24. interpro_conserved_site/metrics.json +7 -0
  25. interpro_conserved_site/paths.json +1 -0
  26. interpro_conserved_site/result.tsv +27 -0
  27. interpro_conserved_site/selections.json +1 -0
  28. interpro_domain/advanced/idx2term.json +1 -0
  29. interpro_domain/basic/idx2term.json +1 -0
  30. interpro_domain/basic/plot_0.png +3 -0
  31. interpro_domain/basic/plot_1.png +3 -0
  32. interpro_domain/basic/plot_2.png +3 -0
  33. interpro_domain/basic/plot_3.png +3 -0
  34. interpro_domain/basic/plot_4.png +3 -0
  35. interpro_domain/basic/plot_5.png +3 -0
  36. interpro_domain/consensus.joblib +3 -0
  37. interpro_domain/df_merge.tsv +4 -0
  38. interpro_domain/metrics.json +7 -0
  39. interpro_domain/paths.json +1 -0
  40. interpro_domain/result.tsv +169 -0
  41. interpro_domain/selections.json +0 -0
  42. interpro_family/advanced/idx2term.json +1 -0
  43. interpro_family/basic/idx2term.json +1 -0
  44. interpro_family/basic/plot_0.png +3 -0
  45. interpro_family/basic/plot_1.png +3 -0
  46. interpro_family/basic/plot_2.png +3 -0
  47. interpro_family/basic/plot_3.png +3 -0
  48. interpro_family/consensus.joblib +3 -0
  49. interpro_family/df_merge.tsv +1 -0
  50. interpro_family/metrics.json +7 -0
interpro_active_site/advanced/idx2term.json ADDED
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+ {}
interpro_active_site/basic/idx2term.json ADDED
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+ {}
interpro_active_site/consensus.joblib ADDED
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interpro_active_site/df_merge.tsv ADDED
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
interpro_active_site/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
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+ {
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+ "type_of_task": "ranksum",
3
+ "signature_size": 2719,
4
+ "annotations_size": 51,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.450980392156863
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+ }
interpro_active_site/paths.json ADDED
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+ {"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C271/C271_val_log2fc"}
interpro_active_site/result.tsv ADDED
@@ -0,0 +1 @@
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
interpro_active_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAPN1", "CAPN2", "CDK1", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK1", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSR", "HADHB", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK3", "MDH1", "MDH2", "MTMR2", "MTMR6", "NEK9", "NME1", "NME2", "NME3", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKACA", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "WNK1"], "leading_proteins": []}
interpro_binding_site/advanced/idx2term.json ADDED
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+ {}
interpro_binding_site/basic/idx2term.json ADDED
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+ {"0": "EF-Hand 1, calcium-binding site [IPR018247]"}
interpro_binding_site/basic/plot_0.png ADDED

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interpro_binding_site/df_merge.tsv ADDED
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
2
+ Peptidase M16, zinc-binding site [IPR001431] 2 5 1.9641754058440437 0.0495097539144202 1.730582524271845 5.0 0.6776547957610433 0.4740055886775391 1.2118895823030245 0.0 0.8079860258854747 0.314626832259423 0.0257267757273305 0.0238038053541035 0.0471521402185075 0.0001338651392195 0.0010568895936515
interpro_binding_site/metrics.json ADDED
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+ {
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+ "type_of_task": "ranksum",
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+ "signature_size": 2719,
4
+ "annotations_size": 30,
5
+ "title": "Average number of proteins per term",
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+ "value": 4.166666666666667
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+ }
interpro_binding_site/paths.json ADDED
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+ {"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C271/C271_val_log2fc"}
interpro_binding_site/result.tsv ADDED
@@ -0,0 +1,5 @@
 
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Peptidase M16, zinc-binding site [IPR001431] 0.8812798275022125 1.9641754058440437 0.0495097539144202 0.7820133310154015 0.1534458018738055 5 Q10713,P22695 2
3
+ Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.8623481781376532 1.3868384987589653 0.1654910147840302 0.9956052870489442 0.3150682733310377 2 P34896 1
4
+ EF-Hand 1, calcium-binding site [IPR018247] 0.4699664841140719 1.378540694885416 0.1680364124432201 0.995990136676794 0.3150682733310377 34 Q14257,P43304,Q96AY3,Q02818,O43852,O95202,P80303,O95302 8
5
+ Beta tubulin, autoregulation binding site [IPR013838] 0.3044810403774085 0.0488114966710174 0.9610695200783628 1.0 0.9610695200783628 6 Q13885,P04350 2
interpro_binding_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "BPNT1", "CALM3", "CALU", "CAPN1", "CAPN2", "CDK1", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHEK1", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD4", "EIF2AK2", "EPS15L1", "FKBP10", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK4", "TBK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP10", "FKBP9", "GPD2", "LETM1", "NUCB1", "NUCB2", "PMPCA", "RCN2", "SHMT1", "TUBB2A", "TUBB4A", "UQCRC2"]}
interpro_conserved_site/advanced/idx2term.json ADDED
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interpro_conserved_site/basic/idx2term.json ADDED
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+ {"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "14-3-3 protein, conserved site [IPR023409]"}
interpro_conserved_site/basic/plot_0.png ADDED

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interpro_conserved_site/consensus.joblib ADDED
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interpro_conserved_site/df_merge.tsv ADDED
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
interpro_conserved_site/metrics.json ADDED
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+ {
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+ "type_of_task": "ranksum",
3
+ "signature_size": 2719,
4
+ "annotations_size": 256,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.55859375
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+ }
interpro_conserved_site/paths.json ADDED
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+ {"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C271/C271_val_log2fc"}
interpro_conserved_site/result.tsv ADDED
@@ -0,0 +1,27 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Haem oxygenase conserved site [IPR018207] 0.9819654030180348 1.8786287008585656 0.060295209403967 0.9999998781546762 0.2953162717988427 2 P09601 1
3
+ Proteasome beta-type subunit, conserved site [IPR016050] 0.6672014755094916 1.4218318120012283 0.1550750821017625 1.0 0.487968950410467 8 P28072,P28074,P28070,P20618,P49721 5
4
+ Mini-chromosome maintenance, conserved site [IPR018525] 0.634939127279591 1.175518668053807 0.2397872730287258 1.0 0.577649899126306 6 Q14566 1
5
+ Zinc finger, RING-type, conserved site [IPR017907] 0.5982428985377055 1.043371524115754 0.2967762566909031 1.0 0.6239558854453876 7 P19474 1
6
+ Chromo domain, conserved site [IPR023779] 0.7429689536676645 1.0031907720989348 0.3157688244960068 1.0 0.6239558854453876 4 Q13185,P45973 2
7
+ Tetraspanin, conserved site [IPR018503] 0.8078055964653911 0.9895751651268022 0.3223818137766374 1.0 0.6299980482963297 3 O60637,O43657 2
8
+ ABC transporter-like, conserved site [IPR017871] 0.5437828226512931 0.9593837661096448 0.3373654502127938 1.0 0.649933121204451 9 Q03518 1
9
+ Dynamin, GTPase region, conserved site [IPR019762] 0.7478836952521195 0.9236266524128012 0.3556807323382158 1.0 0.6598135324535018 2 P50570 1
10
+ Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.5653426778887302 0.9059603636865086 0.3649568321193879 1.0 0.6626166597344915 7 P05091,P51648 2
11
+ Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.664578154750161 0.7233593608298039 0.4694591319153112 1.0 0.7606426441159473 4 P48735 1
12
+ Cyclic nucleotide-binding, conserved site [IPR018488] 0.6779536253220511 0.6600407557292004 0.5092276756178393 1.0 0.7885652416882003 2 P10644 1
13
+ Guanylate kinase, conserved site [IPR020590] 0.6362623499198907 0.6271817128416667 0.5305401290425762 1.0 0.7893696852213243 4 O14936,Q9NZW5 2
14
+ 14-3-3 protein, conserved site [IPR023409] 0.4869148544047165 0.5755278573682666 0.5649343560104265 1.0 0.7893696852213243 6 P27348,P31946,Q04917,P62258,P61981 5
15
+ Annexin repeat, conserved site [IPR018252] 0.3992537957984245 0.2711609192127612 0.7862672692161339 1.0 0.9233230317400472 6 P09525 1
16
+ Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.5636966126656863 0.2530856039508302 0.8002020632062301 1.0 0.9303489134484167 3 Q08257,Q8N4Q0 2
17
+ Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.5399337504600731 0.251340417277029 0.8015509293600462 1.0 0.9303489134484167 2 P82675 1
18
+ Thioredoxin, conserved site [IPR017937] 0.3507622488026797 0.1809786749738703 0.8563843145132168 1.0 0.9573553908968712 10 Q9H1E5,O43396,Q9H3N1 3
19
+ Dynein light chain, type 1/2, conserved site [IPR019763] 0.4825174825174894 0.1482227524871985 0.8821669762581172 1.0 0.9776395927362684 2 P63167 1
20
+ Ribosomal protein L7Ae conserved site [IPR004037] 0.4677953625322131 0.1288213533170997 0.8974990088082977 1.0 0.9823338518741574 2 P55769 1
21
+ HMG box A DNA-binding domain, conserved site [IPR017967] 0.4874815905743757 0.1239423006997155 0.9013609600294136 1.0 0.9823338518741574 3 O15347,P09429 2
22
+ Profilin conserved site [IPR027310] 0.4324622745675444 0.0930223275198743 0.925885823332343 1.0 0.9884704746866352 2 P35080 1
23
+ Actin, conserved site [IPR004001] 0.4317261685682828 0.092426052476175 0.926359541133549 1.0 0.9884704746866352 2 P61163 1
24
+ Intermediate filament protein, conserved site [IPR018039] 0.3192485441651412 0.060262855595844 0.9519462850950208 1.0 0.9884704746866352 8 P07197,P08670 2
25
+ Alcohol dehydrogenase, zinc-type, conserved site [IPR002328] 0.3525947736474136 0.0553025998936573 0.9558973909225208 1.0 0.9884704746866352 2 Q00796 1
26
+ D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752] 0.3367684946632403 0.0524642373728699 0.958158790514182 1.0 0.9884704746866352 2 O43175 1
27
+ Tubulin, conserved site [IPR017975] 0.3044810403774085 0.0488114966710174 0.9610695200783628 1.0 0.9884704746866352 6 Q13885,P04350 2
interpro_conserved_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase, RluC/RluD, conserved site [IPR006224]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB6", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAK1", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BRCA1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAP2", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC1", "DSG2", "DST", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPDR1", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPB", "GNPDA1", "GNS", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KATNB1", "KDSR", "KIF11", "KIF13B", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIF5C", "KIFC1", "LAMP1", "LARS", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPST", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NFKB2", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIN1", "PLEC", "PLOD1", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "PPIB", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RPUSD2", "RRP9", "RSF1", "S100A10", "S100A11", "SART1", "SBDS", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX12", "STX18", "STX4", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP24", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACTR1A", "ALDH2", "ALDH3A2", "ANXA4", "CASK", "CBX3", "CBX5", "CRYZ", "DNM2", "DYNLL1", "HMGB1", "HMGB3", "HMOX1", "IDH2", "MCM6", "MPP6", "MRPS5", "NEFM", "PFN2", "PHGDH", "PRKAR1A", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "SNU13", "SORD", "TAP1", "TMX1", "TMX4", "TRIM21", "TSPAN3", "TSPAN6", "TUBB2A", "TUBB4A", "TXNL1", "VIM", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "ZADH2"]}
interpro_domain/advanced/idx2term.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {}
interpro_domain/basic/idx2term.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"0": "EF-hand domain [IPR002048]", "1": "14-3-3 domain [IPR023410]", "2": "HECT domain [IPR000569]", "3": "Band 7 domain [IPR001107]", "4": "SH3 domain [IPR001452]", "5": "Alcohol dehydrogenase, N-terminal [IPR013154]"}
interpro_domain/basic/plot_0.png ADDED

Git LFS Details

  • SHA256: 82f94c8a089461a463b12bc601698a69a88c778a48359ba8a5a7d561df535672
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  • Size of remote file: 132 kB
interpro_domain/basic/plot_1.png ADDED

Git LFS Details

  • SHA256: 2b51df368f54c6eb3398d1058d43d608df60dce948b4c63b0fed14f352aa2a49
  • Pointer size: 131 Bytes
  • Size of remote file: 131 kB
interpro_domain/basic/plot_2.png ADDED

Git LFS Details

  • SHA256: ae2aba90277a2417e1300889ca9247a47cacee050354c37c9e8bf24a9d7db949
  • Pointer size: 131 Bytes
  • Size of remote file: 131 kB
interpro_domain/basic/plot_3.png ADDED

Git LFS Details

  • SHA256: a40e3e921dce50a0a54af980e3c84e3f3caf6f4b4063aa1e188d68106566903d
  • Pointer size: 131 Bytes
  • Size of remote file: 133 kB
interpro_domain/basic/plot_4.png ADDED

Git LFS Details

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  • Pointer size: 131 Bytes
  • Size of remote file: 144 kB
interpro_domain/basic/plot_5.png ADDED

Git LFS Details

  • SHA256: 31ccabe40751d9659dc9c612e0f695248c39312c826f55f2bd8c6d0f2b705617
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  • Size of remote file: 138 kB
interpro_domain/consensus.joblib ADDED
@@ -0,0 +1,3 @@
 
 
 
 
1
+ version https://git-lfs.github.com/spec/v1
2
+ oid sha256:144716e684ea3bb0d731dba4b407528131bab1849e8b37fc07cc61afc414e0f2
3
+ size 293772
interpro_domain/df_merge.tsv ADDED
@@ -0,0 +1,4 @@
 
 
 
 
 
1
+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
2
+ Cytochrome b5-like heme/steroid binding domain [IPR001199] 4 6 2.380896094963888 0.0172705826111971 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0016924642526821 0.0014481500629001 3.74476751148508e-06 5.41373461507268e-06 0.0001575214550341
3
+ Peptidase M16, N-terminal [IPR011765] 3 7 2.08691708897003 0.0368956298661145 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 0.0358346609821331 0.0331691185540615 0.0653907127050202 1.093284607508717e-05 0.0001708540892308
4
+ Peptidase M16, C-terminal [IPR007863] 3 7 2.08691708897003 0.0368956298661145 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 0.0358346609821331 0.0331691185540615 0.0653907127050202 1.093284607508717e-05 0.0001708540892308
interpro_domain/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
1
+ {
2
+ "type_of_task": "ranksum",
3
+ "signature_size": 2719,
4
+ "annotations_size": 2332,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.0806174957118353
7
+ }
interpro_domain/paths.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C271/C271_val_log2fc"}
interpro_domain/result.tsv ADDED
@@ -0,0 +1,169 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.9377540766845018 2.380896094963888 0.0172705826111971 1.0 0.1150714247123195 6 Q8WUJ1,Q9UMX5,O43169,O15173 4
3
+ Peptidase M16, N-terminal [IPR011765] 0.8539428220208859 2.08691708897003 0.0368956298661145 1.0 0.1675562380553583 7 O43847,Q10713,P22695 3
4
+ Peptidase M16, C-terminal [IPR007863] 0.8539428220208859 2.08691708897003 0.0368956298661145 1.0 0.1675562380553583 7 O43847,Q10713,P22695 3
5
+ LEM domain [IPR003887] 0.7924495240062505 1.8192726064359617 0.0688698504921048 1.0 0.2337874339063404 6 P42167,Q86XL3 2
6
+ Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.9573058520426948 1.7777540515799115 0.0754442580129377 1.0 0.2462826500094096 2 Q13505 1
7
+ Metaxin, glutathione S-transferase domain [IPR033468] 0.9573058520426948 1.7777540515799115 0.0754442580129377 1.0 0.2462826500094096 2 Q13505 1
8
+ Fatty acid hydroxylase [IPR006694] 0.9488406330511594 1.7430279472627084 0.0813287331889409 1.0 0.2584796900294852 2 Q15800 1
9
+ TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9337205695128854 1.7078591303347157 0.0876624841846602 1.0 0.266878476656172 4 Q15629,Q96CP7 2
10
+ RBM3/CIRBP, RNA recognition motif [IPR034278] 0.9157158630842844 1.6067853354636 0.1081014662304062 1.0 0.3069544398505739 2 Q14011 1
11
+ Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.786817543659416 1.599043854180994 0.1098108586829225 1.0 0.3096480319813486 5 Q9NZ08,P55786 2
12
+ Aminopeptidase N-like , N-terminal domain [IPR045357] 0.786817543659416 1.599043854180994 0.1098108586829225 1.0 0.3096480319813486 5 Q9NZ08,P55786 2
13
+ FAD-binding domain, PCMH-type [IPR016166] 0.912403386087598 1.5931380626452916 0.1111292222006781 1.0 0.3122329471951582 2 Q15392 1
14
+ FAD linked oxidase, N-terminal [IPR006094] 0.912403386087598 1.5931380626452916 0.1111292222006781 1.0 0.3122329471951582 2 Q15392 1
15
+ ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.8770702981229308 1.4474855403443845 0.1477609833501079 1.0 0.3751661762032891 2 Q5T9A4 1
16
+ Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542] 0.8763341921236675 1.4444517348287709 0.1486119470496734 1.0 0.3760757084076002 2 Q9Y282 1
17
+ Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936] 0.8763341921236675 1.4444517348287709 0.1486119470496734 1.0 0.3760757084076002 2 Q9Y282 1
18
+ Reticulon [IPR003388] 0.9289396170839472 1.428620721305247 0.1531132751392567 1.0 0.3818825215237933 3 O95197,Q9NQC3 2
19
+ Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.869709238130292 1.4171534521363 0.1564380675808288 1.0 0.3868648712603316 2 O60506 1
20
+ MENTAL domain [IPR019498] 0.8656606551343411 1.4004777078386317 0.1613703143302651 1.0 0.3900435558700842 2 Q14849 1
21
+ Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.8630842841369171 1.3898690440405268 0.1645686472710454 1.0 0.3952359273286077 2 P51114 1
22
+ Serine hydroxymethyltransferase-like domain [IPR039429] 0.8623481781376532 1.3868384987589653 0.1654910147840302 1.0 0.3954150066356133 2 P34896 1
23
+ ELMO domain [IPR006816] 0.8535149061464866 1.3504921851258718 0.1768581587437883 1.0 0.4128460722627771 2 Q8IZ81 1
24
+ EF-hand domain [IPR002048] 0.4423068785605928 1.288745972039257 0.1974864144946153 1.0 0.4381519911436311 39 Q14257,P43304,Q96AY3,Q02818,O43852,O95202,P80303,O95302 8
25
+ P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8127691288614206 1.2606900079297552 0.2074205553697594 1.0 0.4415751572230171 4 Q9HD20 1
26
+ Sam68, tyrosine-rich domain [IPR032335] 0.8314317261685701 1.2598538089328415 0.2077221044055102 1.0 0.4415751572230171 2 O75525 1
27
+ KHDRBS, Qua1 domain [IPR032571] 0.8314317261685701 1.2598538089328415 0.2077221044055102 1.0 0.4415751572230171 2 O75525 1
28
+ ERAP1-like C-terminal domain [IPR024571] 0.8784977908689253 1.24452407702268 0.2133067436625495 1.0 0.4472960351694915 3 Q9NZ08,P55786 2
29
+ ABC transporter type 1, transmembrane domain [IPR011527] 0.6911160180412258 1.2201429117177018 0.2224107037418203 1.0 0.4569593005098301 5 Q03518 1
30
+ Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8646791292250189 1.1942789725461285 0.2323688601349736 1.0 0.4703855745093389 3 Q32P28 1
31
+ GOLD domain [IPR009038] 0.6303255878076641 1.177830767200898 0.2388640801795554 1.0 0.4801991680851062 7 Q9Y3A6,Q9H3P7,O76054,Q9BVK6 4
32
+ MCM, AAA-lid domain [IPR041562] 0.634939127279591 1.175518668053807 0.2397872730287258 1.0 0.480398557304973 6 Q14566 1
33
+ MCM OB domain [IPR033762] 0.634939127279591 1.175518668053807 0.2397872730287258 1.0 0.480398557304973 6 Q14566 1
34
+ MCM domain [IPR001208] 0.634939127279591 1.175518668053807 0.2397872730287258 1.0 0.480398557304973 6 Q14566 1
35
+ MCM N-terminal domain [IPR027925] 0.634939127279591 1.175518668053807 0.2397872730287258 1.0 0.480398557304973 6 Q14566 1
36
+ Glutathione S-transferase, N-terminal [IPR004045] 0.6271082573455373 1.1643489925047026 0.2442826096210764 1.0 0.4852359843580496 7 P21266,Q9H7Z7 2
37
+ Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.6189425317872658 1.1091384542030565 0.2673704581616254 1.0 0.509308776171387 6 Q9UDY2,O14936,Q9NZW5 3
38
+ Guanylate kinase-like domain [IPR008144] 0.6189425317872658 1.1091384542030565 0.2673704581616254 1.0 0.509308776171387 6 Q9UDY2,O14936,Q9NZW5 3
39
+ GMP phosphodiesterase, delta subunit [IPR008015] 0.8361561119293083 1.091094865123772 0.2752311420630668 1.0 0.5209732331908051 3 O43924,A6NIH7 2
40
+ Zinc finger, RanBP2-type [IPR001876] 0.5885673941737919 1.0792382059064942 0.2804815519730437 1.0 0.5274862735493047 8 Q92804,P35637 2
41
+ 4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896] 0.8221690134652717 1.0408514416849026 0.2979445010923824 1.0 0.5440928555578981 3 P21912 1
42
+ FAD dependent oxidoreductase [IPR006076] 0.7522282984410833 1.0370848529834422 0.2996963136985517 1.0 0.5447325047116311 4 Q9H9P8,P43304 2
43
+ Peptidase M3A/M3B catalytic domain [IPR001567] 0.8195876288659799 1.0316105227315424 0.302254608912778 1.0 0.5454595383154528 3 P52888,Q9BYT8 2
44
+ CARG-binding factor, N-terminal [IPR012956] 0.7721751932278278 1.0197831721257966 0.3078313057511974 1.0 0.550508132677755 2 Q99729 1
45
+ Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.7461067172586375 1.014663376119362 0.3102663177553433 1.0 0.5514794611322108 4 Q32P28 1
46
+ Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.7461067172586375 1.014663376119362 0.3102663177553433 1.0 0.5514794611322108 4 Q32P28 1
47
+ Zinc finger, CHHC-type [IPR012996] 0.809646539027983 0.9961269657615704 0.3191884593116088 1.0 0.5571463226906225 3 P52597,P31943 2
48
+ Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.7659182922340848 0.9948527276755424 0.3198078971340288 1.0 0.5573931361110278 2 P51812 1
49
+ Phospholipid/glycerol acyltransferase [IPR002123] 0.8055964653902805 0.9817214031251263 0.3262371181408072 1.0 0.5627107688641735 3 Q9NUQ2,Q99943 2
50
+ CRAL-TRIO lipid binding domain [IPR001251] 0.7581891792418141 0.9642059849938048 0.3349426643647244 1.0 0.568890235468709 2 O76054 1
51
+ ABC transporter-like, ATP-binding domain [IPR003439] 0.5437828226512931 0.9593837661096448 0.3373654502127938 1.0 0.5700421833598988 9 Q03518 1
52
+ AP complex, mu/sigma subunit [IPR022775] 0.6179119474801371 0.9302102766084992 0.3522622220893345 1.0 0.5832794070753738 5 Q9Y2T2 1
53
+ Dynamin stalk domain [IPR000375] 0.7478836952521195 0.9236266524128012 0.3556807323382158 1.0 0.5835678807673882 2 P50570 1
54
+ GTPase effector domain [IPR020850] 0.7478836952521195 0.9236266524128012 0.3556807323382158 1.0 0.5835678807673882 2 P50570 1
55
+ Dynamin GTPase effector [IPR003130] 0.7478836952521195 0.9236266524128012 0.3556807323382158 1.0 0.5835678807673882 2 P50570 1
56
+ Chromo shadow domain [IPR008251] 0.7853460972017681 0.910198988243424 0.3627175776444686 1.0 0.5889805307875522 3 Q13185,P45973 2
57
+ Chromo domain subgroup [IPR017984] 0.7853460972017681 0.910198988243424 0.3627175776444686 1.0 0.5889805307875522 3 Q13185,P45973 2
58
+ Heat shock chaperonin-binding [IPR006636] 0.7046553127811329 0.8645002030982394 0.387313168811159 1.0 0.6100083667091253 4 P31948,Q9BSL1 2
59
+ Peptidase M20, dimerisation domain [IPR011650] 0.7224880382775156 0.825249523239917 0.4092299426717916 1.0 0.6271266215966721 2 Q96KP4 1
60
+ Immunoglobulin subtype [IPR003599] 0.5865490286567918 0.8082495868203281 0.4189469173666782 1.0 0.6346825300852189 5 P10586,Q8WX93 2
61
+ Dynamin, GTPase domain [IPR001401] 0.7481590574374088 0.7816162360324146 0.4344401422015667 1.0 0.6405274404014358 3 P50570,O60313 2
62
+ Far upstream element-binding protein, C-terminal [IPR015096] 0.7085020242915021 0.7722385756983633 0.4399731379665392 1.0 0.6452776362632252 2 Q92945 1
63
+ PITH domain [IPR010400] 0.7081339712918702 0.7708562497949031 0.4407921417527092 1.0 0.6452776362632252 2 O43396 1
64
+ APC10/DOC domain [IPR004939] 0.7033492822966549 0.7529488359787815 0.451480660022953 1.0 0.6483068904901229 2 Q5T447 1
65
+ Isopropylmalate dehydrogenase-like domain [IPR024084] 0.664578154750161 0.7233593608298039 0.4694591319153112 1.0 0.6606992731602328 4 P48735 1
66
+ ZU5 domain [IPR000906] 0.6915715863084326 0.7093919481399995 0.4780812830270073 1.0 0.6671966199993903 2 Q12955 1
67
+ Tyrosine-specific protein phosphatase, PTPase domain [IPR000242] 0.7135493372606785 0.666277681981103 0.5052336280779175 1.0 0.6874007121806905 3 P18031,P10586 2
68
+ Immunoglobulin I-set [IPR013098] 0.7124436135872123 0.662677525156138 0.5075371068962797 1.0 0.6875192996622498 3 Q8WX93 1
69
+ cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.6779536253220511 0.6600407557292004 0.5092276756178393 1.0 0.6880179255740448 2 P10644 1
70
+ Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.7025922302532797 0.6308633355557308 0.5281298868242694 1.0 0.7029674064350435 3 P16615 1
71
+ Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.7025922302532797 0.6308633355557308 0.5281298868242694 1.0 0.7029674064350435 3 P16615 1
72
+ Sec24-like, trunk domain [IPR041742] 0.6628634523371415 0.6067694697684171 0.5440039118641593 1.0 0.7131068704144011 2 O95486 1
73
+ Tyrosine-specific protein phosphatases domain [IPR000387] 0.4935094006740392 0.600809715927354 0.5479667320863759 1.0 0.7135725577141521 6 Q13614,P18031,P10586 3
74
+ Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.6558704453441345 0.5826356824213458 0.5601385792099312 1.0 0.7203586749134261 2 Q9NR33 1
75
+ 14-3-3 domain [IPR023410] 0.4869148544047165 0.5755278573682666 0.5649343560104265 1.0 0.7218777634061998 6 P27348,P31946,Q04917,P62258,P61981 5
76
+ Glutathione S-transferase, C-terminal-like [IPR010987] 0.4442343289652076 0.5731911437255371 0.566515280179251 1.0 0.7231610628518688 10 P21266,Q9H7Z7 2
77
+ L27 domain, C-terminal [IPR014775] 0.6741397611647741 0.5418922748221857 0.5878927188710799 1.0 0.7343148475668764 3 Q9NZW5 1
78
+ L27 domain [IPR004172] 0.6741397611647741 0.5418922748221857 0.5878927188710799 1.0 0.7343148475668764 3 Q9NZW5 1
79
+ SUN domain [IPR012919] 0.6374677953625376 0.5209709217924504 0.602387028051635 1.0 0.7440500791400492 2 Q9ULT8 1
80
+ Sterile alpha motif domain [IPR001660] 0.6026273206041626 0.5181300708299232 0.604367520816194 1.0 0.7446404521087953 4 Q13136 1
81
+ Chromo domain [IPR023780] 0.5039276143520515 0.504072622369382 0.6142103448580853 1.0 0.7502876158169934 5 Q13185,P45973 2
82
+ FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.4265793196729767 0.4931194896041722 0.6219281606103237 1.0 0.7561712568004563 10 O95302 1
83
+ Class II aldolase/adducin N-terminal [IPR001303] 0.6220095693779961 0.4714375619543181 0.6373282977382768 1.0 0.7680876435791533 2 Q9UEY8 1
84
+ HECT domain [IPR000569] 0.4452231648838006 0.4699484387555114 0.6383918559761235 1.0 0.7686873606383576 8 Q96PU5,Q7Z6Z7,Q15386,Q9ULT8,Q9UII4,Q5T447,Q96J02 7
85
+ Immunoglobulin subtype 2 [IPR003598] 0.5867471982911927 0.4690518905135223 0.6390325458489019 1.0 0.7686873606383576 4 Q8WX93 1
86
+ PIK-related kinase [IPR014009] 0.6201693043798364 0.4656890907385076 0.6414380622125102 1.0 0.7694617083742664 2 P42345 1
87
+ FATC domain [IPR003152] 0.6201693043798364 0.4656890907385076 0.6414380622125102 1.0 0.7694617083742664 2 P42345 1
88
+ PIK-related kinase, FAT [IPR003151] 0.6201693043798364 0.4656890907385076 0.6414380622125102 1.0 0.7694617083742664 2 P42345 1
89
+ RNA recognition motif domain, eukaryote [IPR003954] 0.3847370082374839 0.3938065041258065 0.693723902066544 1.0 0.8084778308941433 12 Q14011,Q9UHX1 2
90
+ Band 7 domain [IPR001107] 0.434942867674166 0.3866043977809617 0.6990491016924385 1.0 0.812248383232071 6 O94905,P35232,Q14254,Q99623,Q9UJZ1 5
91
+ SAC3/GANP/THP3, conserved domain [IPR005062] 0.5899889584100173 0.3763389664284248 0.7066649139388086 1.0 0.8197071033374066 2 Q96PV6 1
92
+ Immunoglobulin-like domain [IPR007110] 0.4185192539518461 0.3672703931384301 0.7134173361480922 1.0 0.8240164576014617 8 Q08722,P10321,P10586,Q8WX93 4
93
+ Ubiquitin-associated domain [IPR015940] 0.3973506182728127 0.3655079786784045 0.7147322520869195 1.0 0.8251265405280674 10 Q9Y5A7,Q9UPU5 2
94
+ U-box domain [IPR003613] 0.4541429965191241 0.3421896894599291 0.7322081440188213 1.0 0.8361946091341289 5 P19474 1
95
+ JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.4176761942620252 0.3322627589474733 0.7396908580374137 1.0 0.8422651762418207 7 O00303 1
96
+ Fibronectin type III [IPR003961] 0.5693779904306286 0.3211323472333946 0.7481100979016295 1.0 0.8497772763305407 2 P10586 1
97
+ NOPS [IPR012975] 0.5854197349042722 0.3012729586549289 0.7632063594224654 1.0 0.864398849039917 3 Q15233,P23246 2
98
+ Agenet-like domain [IPR008395] 0.58366604920165 0.2972069661006546 0.7663085038607922 1.0 0.8662294866715305 3 P51114 1
99
+ Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.58366604920165 0.2972069661006546 0.7663085038607922 1.0 0.8662294866715305 3 P51114 1
100
+ Fragile X-related 1 protein, C-terminal core [IPR022034] 0.58366604920165 0.2972069661006546 0.7663085038607922 1.0 0.8662294866715305 3 P51114 1
101
+ Fxr1, tudor domain [IPR041560] 0.58366604920165 0.2972069661006546 0.7663085038607922 1.0 0.8662294866715305 3 P51114 1
102
+ Vicinal oxygen chelate (VOC) domain [IPR037523] 0.5550239234449827 0.2857273414696424 0.7750869618517513 1.0 0.8744570851660785 2 Q9HC38 1
103
+ 3'-5' exonuclease domain [IPR002562] 0.5491350754508718 0.2719566406909106 0.7856553588812039 1.0 0.8837357812951425 2 Q9NVH0 1
104
+ Rhodanese-like domain [IPR001763] 0.5721649484536097 0.2713003275660789 0.7861600545509924 1.0 0.8837357812951425 3 Q99956,Q8NCN5 2
105
+ Saposin B type domain [IPR008139] 0.5414059624586012 0.2545645114541056 0.799059472053854 1.0 0.8932917971378656 2 Q9Y2B0 1
106
+ Ribosomal protein S5, N-terminal [IPR013810] 0.5399337504600731 0.251340417277029 0.8015509293600462 1.0 0.8952187582699368 2 P82675 1
107
+ Ribosomal protein S5, C-terminal [IPR005324] 0.5399337504600731 0.251340417277029 0.8015509293600462 1.0 0.8952187582699368 2 P82675 1
108
+ Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038] 0.4174649963154031 0.2388656801265176 0.8112097385837103 1.0 0.905139287261824 5 P62888,Q9NX24,P55769,P62424 4
109
+ Protein kinase, C-terminal [IPR017892] 0.5543871005366425 0.2339255642282513 0.8150427663651572 1.0 0.90677416304082 3 P51812 1
110
+ SH3 domain [IPR001452] 0.3233759036263727 0.2242325304595938 0.8225763722199262 1.0 0.9121484070455862 28 Q96PC5,P46108,P62993,Q9UDY2,Q9UQB8,Q9NZW5 6
111
+ Tudor domain [IPR002999] 0.3773500907203794 0.2231349754245208 0.8234304580382268 1.0 0.9126615152781108 8 Q16637,Q14739,Q9Y2W6 3
112
+ G-protein, beta subunit [IPR001632] 0.520794994479212 0.2120489146901245 0.8320688735066353 1.0 0.91787351609152 2 Q9NVX2 1
113
+ Zinc finger C2H2 AKAP95-type [IPR034736] 0.5354695993008588 0.1978496018602814 0.8431627364932928 1.0 0.926604854619396 3 Q9ULX6 1
114
+ ABC-transporter extension domain [IPR032781] 0.4942951785057104 0.165774459852477 0.8683344460774836 1.0 0.9400463315658468 2 Q9NUQ8 1
115
+ Survival motor neuron [IPR010304] 0.4898785425101294 0.1589777193704356 0.8736864279321308 1.0 0.944131950851589 2 Q16637 1
116
+ Staufen, C-terminal [IPR032478] 0.4887743835112337 0.1573189641299394 0.8749934751390793 1.0 0.9451064307662496 2 Q9NUL3 1
117
+ Intermediate filament head, DNA-binding domain [IPR006821] 0.4549536180536619 0.148567360030796 0.8818950300422694 1.0 0.9504164052934272 4 P08670 1
118
+ ENTH domain [IPR013809] 0.4821494295178588 0.147703662700639 0.8825766409286591 1.0 0.9504164052934272 2 Q13492 1
119
+ MPN domain [IPR037518] 0.3411298276232046 0.1466734232866287 0.8833897968411919 1.0 0.9504164052934272 10 O00303 1
120
+ Ribosomal protein L2, C-terminal [IPR022669] 0.4814133235185935 0.1466707825980184 0.8833918812640595 1.0 0.9504164052934272 2 P62917 1
121
+ Ribosomal Proteins L2, RNA binding domain [IPR022666] 0.4814133235185935 0.1466707825980184 0.8833918812640595 1.0 0.9504164052934272 2 P62917 1
122
+ Arf GTPase activating protein [IPR001164] 0.4810452705189606 0.1461569893312356 0.8837974584096138 1.0 0.9504164052934272 2 Q96P47 1
123
+ Alcohol dehydrogenase, N-terminal [IPR013154] 0.3531146332473294 0.1457397687351113 0.8841268256185728 1.0 0.9504164052934272 6 Q08257,Q99536,Q00796,Q8N4Q0,Q9BV79 5
124
+ AGC-kinase, C-terminal [IPR000961] 0.370302137067071 0.1312367242083085 0.895588045458795 1.0 0.9576559962782144 5 Q16513,P51812,Q15418,P17612 4
125
+ Major sperm protein (MSP) domain [IPR000535] 0.4930044182621519 0.131162780317548 0.8956465385432186 1.0 0.9576559962782144 3 Q9P0L0,Q8NHP6 2
126
+ PABP, RNA recognition motif 2 [IPR045305] 0.4626426205373659 0.1226786956537104 0.9023615348201944 1.0 0.9623660527602188 2 P11940 1
127
+ Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.4626426205373659 0.1226786956537104 0.9023615348201944 1.0 0.9623660527602188 2 P11940 1
128
+ Ribosomal L28e/Mak16 [IPR029004] 0.4390872285609217 0.0986490762508181 0.9214169028139624 1.0 0.9749293182223956 2 P46779 1
129
+ Cobalamin (vitamin B12)-binding domain [IPR006158] 0.4306220095693871 0.091542290985544 0.9270617039366712 1.0 0.97912495180268 2 Q99707 1
130
+ MIRO domain [IPR020860] 0.4251012145749057 0.0873120882086012 0.9304234457158196 1.0 0.9813421417500188 2 Q8IXI1 1
131
+ EF hand associated, type-2 [IPR013567] 0.4251012145749057 0.0873120882086012 0.9304234457158196 1.0 0.9813421417500188 2 Q8IXI1 1
132
+ EF hand associated, type-1 [IPR013566] 0.4251012145749057 0.0873120882086012 0.9304234457158196 1.0 0.9813421417500188 2 Q8IXI1 1
133
+ Exportin-2, central domain [IPR013713] 0.4488217967599429 0.0823317159273735 0.9343829343623362 1.0 0.9836344980026344 3 O15397,O95373 2
134
+ Methyl-CpG DNA binding [IPR001739] 0.448085419734906 0.081684038479245 0.934897971387306 1.0 0.9836344980026344 3 Q15047,O95983 2
135
+ Longin domain [IPR010908] 0.4155318365844769 0.0806965422811108 0.9356832867100424 1.0 0.9836344980026344 2 O75396 1
136
+ v-SNARE, coiled-coil homology domain [IPR042855] 0.4155318365844769 0.0806965422811108 0.9356832867100424 1.0 0.9836344980026344 2 O75396 1
137
+ WWE domain [IPR004170] 0.444403534609722 0.0785224045927131 0.9374125089555336 1.0 0.9836344980026344 3 Q7Z2W4,Q7Z6Z7 2
138
+ Ataxin-2, C-terminal [IPR009818] 0.4440353460972036 0.0782132240231705 0.9376584429930774 1.0 0.9836344980026344 3 Q8WWM7,Q9H074 2
139
+ Intermediate filament, rod domain [IPR039008] 0.3192485441651412 0.060262855595844 0.9519462850950208 1.0 0.98985410376034 8 P07197,P08670 2
140
+ Legume-like lectin [IPR005052] 0.3669488406330592 0.0588504295471679 0.9530712410631376 1.0 0.98985410376034 2 Q12907 1
141
+ CAP Gly-rich domain [IPR000938] 0.3852670349907963 0.0575249297235428 0.9541270479381524 1.0 0.98985410376034 4 Q14203,Q99426,Q9NQT8 3
142
+ Synaptotagmin, SMP domain [IPR039010] 0.3595877806404203 0.0569017661519581 0.954623447408664 1.0 0.98985410376034 2 A0FGR8 1
143
+ Extended synaptotagmin, C2A domain [IPR037733] 0.3595877806404203 0.0569017661519581 0.954623447408664 1.0 0.98985410376034 2 A0FGR8 1
144
+ Extended synaptotagmin, C2B domain [IPR037749] 0.3595877806404203 0.0569017661519581 0.954623447408664 1.0 0.98985410376034 2 A0FGR8 1
145
+ Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.3595877806404203 0.0569017661519581 0.954623447408664 1.0 0.98985410376034 2 A0FGR8 1
146
+ Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.3595877806404203 0.0569017661519581 0.954623447408664 1.0 0.98985410376034 2 A0FGR8 1
147
+ B-box, C-terminal [IPR003649] 0.3264630106735455 0.051102386476493 0.9592439343462208 1.0 0.9899355657344266 2 O15164 1
148
+ Potassium channel tetramerisation-type BTB domain [IPR003131] 0.3213102686786984 0.0505407141064767 0.9596915056789042 1.0 0.9899355657344266 2 Q96CX2 1
149
+ Exportin-1/Importin-beta-like [IPR013598] 0.3767955801105087 0.050150069802627 0.9600027999732772 1.0 0.9899355657344266 4 O14980,Q9HAV4,O43592 3
150
+ Nucleotidyl transferase domain [IPR005835] 0.3014354066985737 0.0489676131738718 0.9609451059067238 1.0 0.9899355657344266 2 Q9Y5P6 1
151
+ Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.3044810403774085 0.0488114966710174 0.9610695200783628 1.0 0.9899355657344266 6 Q13885,P04350 2
152
+ Tubulin/FtsZ, GTPase domain [IPR003008] 0.3044810403774085 0.0488114966710174 0.9610695200783628 1.0 0.9899355657344266 6 Q13885,P04350 2
153
+ B-box-type zinc finger [IPR000315] 0.368661285518793 0.0437443993748355 0.9651081474867222 1.0 0.992875416968073 4 P19474 1
154
+ Glutamine amidotransferase type 2 domain [IPR017932] 0.3829160530191476 0.042399135853758 0.9661805172202054 1.0 0.992875416968073 3 P08243,Q06203 2
155
+ TGS [IPR004095] 0.2965623333468273 0.0366751626084766 0.9707440126832804 1.0 0.9955035345547096 6 Q9NTK5 1
156
+ Transcription factor IIS, N-terminal [IPR017923] 0.3416789396170861 0.0315249303141401 0.9748509105074556 1.0 0.9979597556204508 3 Q14241,P23193 2
157
+ Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617] 0.3416789396170861 0.0315249303141401 0.9748509105074556 1.0 0.9979597556204508 3 Q14241,P23193 2
158
+ Lamin tail domain [IPR001322] 0.2901325478645088 0.0261725389966265 0.9791197190831182 1.0 1.0 3 P20700,P02545 2
159
+ Ras GTPase-activating domain [IPR001936] 0.2695139911634779 0.0253730924654923 0.9797573732982612 1.0 1.0 3 Q14C86,Q13576 2
160
+ Glutathione S-transferase, C-terminal [IPR004046] 0.2998846565205162 0.0188316207784426 0.984975428558382 1.0 1.0 8 P21266 1
161
+ Zinc finger, RING-type [IPR001841] 0.2982201445929406 0.0170258586218677 0.9864159865630262 1.0 1.0 16 P19474 1
162
+ Ras-associating (RA) domain [IPR000159] 0.280029476787031 0.0130125406212358 0.989617787739104 1.0 1.0 5 Q15036,Q8TEU7,Q96L92,P55196 4
163
+ Cyclic nucleotide-binding domain [IPR000595] 0.2800294767870298 0.013012540621235 0.9896177877391048 1.0 1.0 5 Q8TEU7,P10644,P13861,Q6P4Q7 4
164
+ Nuclear transport factor 2, eukaryote [IPR018222] 0.2979742173112437 0.0109198469239234 0.9912873958863396 1.0 1.0 4 P61970,Q9UN86,Q9UBU9 3
165
+ Nuclear transport factor 2 domain [IPR002075] 0.2979742173112437 0.0109198469239234 0.9912873958863396 1.0 1.0 4 P61970,Q9UN86,Q9UBU9 3
166
+ CBS domain [IPR000644] 0.2939226519337102 0.0099970287435742 0.9920236579718672 1.0 1.0 4 P51790,P12268,Q6P4Q7 3
167
+ SH2 domain [IPR000980] 0.2941668139541538 0.0079140486515116 0.9936855686820034 1.0 1.0 8 P46108,P62993 2
168
+ Peroxiredoxin, C-terminal [IPR019479] 0.2740331491712763 0.0064692075309384 0.994838355193488 1.0 1.0 4 P30048,Q13162,P32119 3
169
+ Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866] 0.2740331491712763 0.0064692075309384 0.994838355193488 1.0 1.0 4 P30048,Q13162,P32119 3
interpro_domain/selections.json ADDED
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interpro_family/advanced/idx2term.json ADDED
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+ {}
interpro_family/basic/idx2term.json ADDED
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1
+ {"0": "Proteasome B-type subunit [IPR023333]", "1": "Proteasome, subunit alpha/beta [IPR001353]", "2": "Short-chain dehydrogenase/reductase SDR [IPR002347]", "3": "14-3-3 protein [IPR000308]"}
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500
interpro_family/metrics.json ADDED
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+ {
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+ "type_of_task": "ranksum",
3
+ "signature_size": 2719,
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+ "annotations_size": 2153,
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+ "title": "Average number of proteins per term",
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+ "value": 1.2786809103576404
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+ }