Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Protein localization 0.6283578464861267 3.3534101428384244 0.0007982232746048 0.662980415906989 0.4004793444367741 68 Q13505,Q10713,Q9NS69,P40855,P12235,Q99595,O60830,Q8NBU5,Q5JRX3,P09601,P50402,P12236,Q8N4H5,O43765,P51648,Q3ZCQ8,O75874,O14734,P62072,Q15067,O14925,Q9NR77,P21796,Q15388,Q9Y3D6,P46379,Q9BY49,O00116,O75431 29 Mitochondrial protein import 0.7351149685578385 3.1332387933463 0.0017288872404304 0.9052754729018224 0.4004793444367741 33 Q3ZCQ8,Q13505,Q10713,Q9NS69,Q5JRX3,P21796,P62072,Q99595,Q8N4H5,O60830,O75431,O14925 12 Organelle biogenesis and maintenance 0.5477306191438269 2.7832262563728127 0.0053821258776607 0.9993575703429723 0.4004793444367741 85 Q13505,P56385,Q10713,O75964,P41208,A0AVF1,Q15691,A6NIH7,P43034,Q9NX63,Q9Y496,O94927,Q92538,O75935,Q9H6D7,Q13561,Q16539,Q96CS2,Q8NCM8,Q92973,P30153,Q5XKP0,P48735,Q9BUR5,O43924,O95684,O75431,P24539,P06576 29 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5652520939356582 2.5706295178051257 0.0101513860022022 0.9999990781135686 0.4158595146414213 55 P03886,P20674,P56385,O14949,O75964,O96000,P13073,O43676,Q16134,P21912,Q9NX14,Q9NPL8,Q9UDW1,P47985,P00403,P24539,P22695 17 Respiratory electron transport 0.5760576491896711 2.5448682106828877 0.0109318988345181 0.9999996851684508 0.4158595146414213 46 P03886,P20674,O14949,P13073,O96000,O43676,Q16134,P21912,Q9NX14,Q9NPL8,Q9UDW1,P47985,P00403,P22695 14 Slc mediated transmembrane transport 0.7529694186796584 2.4784324896349967 0.0131961081176981 0.9999999861189388 0.4158595146414213 16 Q70HW3,P53985,Q8TB61 3 Glycerophospholipid biosynthesis 0.6579126575649084 2.379468589184582 0.0173376205723143 0.999999999954846 0.4339563182994945 24 Q8IV08,P43304,Q96N66,Q8NCC3,Q9NPH0,P35790,P48651,Q9NUQ2 8 Cilium assembly 0.52762286911709 2.2762439859047583 0.0228314106082556 0.9999999999999782 0.4339563182994945 56 P30153,O94927,Q9Y496,O75935,Q10713,Q92538,Q9H6D7,Q13561,P41208,O43924,A0AVF1,O95684,Q15691,A6NIH7,Q96CS2,Q8NCM8,P43034,Q92973 18 Sphingolipid de novo biosynthesis 0.8120442939128596 2.272404064155982 0.0230621164745048 0.9999999999999842 0.4339563182994945 10 O95470,Q06136,P51648,Q96G23 4 Biological oxidations 0.5619229128781327 2.2458281808763823 0.0247150155058746 0.9999999999999984 0.4339563182994945 40 Q9NUJ1,Q16850,P21964,P05091,P07099,P30837,P16435,O43169,Q99735,P21266,Q8TB61 11 The citric acid tca cycle and respiratory electron transport 0.4899959923172578 2.225933777152611 0.0260186174924392 0.9999999999999998 0.4339563182994945 84 P56385,O75964,O96000,Q13423,P47985,P00403,P22695,O43676,Q9NPL8,Q9UDW1,O14949,Q16134,Q9NX14,P53985,P03886,P20674,P48735,P21796,P13073,P21912,P24539 21 Metabolism of porphyrins 0.8256614055006469 2.2036273654737264 0.0275505611224644 1.0 0.4339563182994945 9 P22830,P09601 2 Transport of small molecules 0.4389278867838677 2.1758751703414423 0.0295645958920629 1.0 0.4339563182994945 128 P60900,Q10713,P40855,Q93050,Q70HW3,Q99576,Q9Y487,Q9UBV2,P09601,P12236,Q8WTV0,P30519,Q9BUN8,P53680,Q9HD20,P28074,Q9Y277,P45880,P16615,P53985,O95202,P49721,Q8TB61,Q9UBX3,P08183,P21796,P28070,O00231,Q9UBI6 29 Transport of inorganic cations anions and amino acids oligopeptides 0.8768003532253902 2.1753618890732307 0.0296030080749118 1.0 0.4339563182994945 7 Q70HW3 1 Mitophagy 0.786328957214302 2.161491818242008 0.0306573682914692 1.0 0.4378226219375831 10 Q8N4H5,Q9NS69,P21796 3 Pink1 prkn mediated mitophagy 0.8725215913023299 2.1588765669578627 0.0308597442775389 1.0 0.4378226219375831 7 Q8N4H5,Q9NS69,P21796 3 Mitochondrial biogenesis 0.5964266430514399 2.148923869025557 0.0316404353639612 1.0 0.4381006004774107 29 Q13505,P48735,O75964,Q9BUR5,Q16539,O75431,Q5XKP0,P24539 8 Mitochondrial calcium ion transport 0.6992651619504877 2.145038530967278 0.0319497664120536 1.0 0.4381006004774107 15 P45880,P21796,Q10713,Q9Y277 4 Phase i functionalization of compounds 0.7038533478377499 2.1123287067674106 0.034658265263703 1.0 0.4495672122777485 14 Q16850,P05091,P07099,P16435,O43169 5 Class i peroxisomal membrane protein import 0.8015140679262066 2.1028706856502737 0.0354770749573689 1.0 0.4558469442635521 9 P40855,Q9NR77,Q9Y3D6,Q8NBU5,P51648 5 Rac2 gtpase cycle 0.5916168618251754 2.095727907797179 0.0361063347247614 1.0 0.4575751114310469 28 Q13505,Q86XL3,O15173,P50402,P42167,Q14739 6 Cristae formation 0.6463560632519683 2.086931425411031 0.0368943337310132 1.0 0.4610099315746793 19 Q13505,Q9BUR5,O75964,O75431,Q5XKP0,P24539 6 Phospholipid metabolism 0.5549079933228263 2.0545173913788153 0.0399256418907538 1.0 0.4855243237072033 36 Q8IV08,P43304,Q10713,P42356,Q96N66,Q9UG56,Q8NCC3,Q9NPH0,P35790,P48651,Q9NUQ2 11 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7514731646680336 1.8900904133297525 0.0587458690379929 1.0 0.6154759509980492 9 P09601,P46379,P50402,P51648 4 Ras processing 0.8581277449097214 1.8757675735957555 0.060687202433959 1.0 0.626181588750396 5 O60725,O43924 2 Cargo trafficking to the periciliary membrane 0.6117306162529894 1.8421290201658505 0.0654562798152851 1.0 0.6367960936315596 18 A6NIH7,Q10713 2 Synthesis of pa 0.7893397814949343 1.806867878898228 0.0707828819075437 1.0 0.6586653024651897 6 Q9NUQ2,P43304,Q99943,Q9NPH0 4 Selective autophagy 0.5438531132335495 1.7807197853537486 0.0749582392673307 1.0 0.6586653024651897 28 Q8N4H5,Q15388,Q9NS69,P21796 4 Synaptic adhesion like molecules 0.7768344774789496 1.7568323840506244 0.0789463834732353 1.0 0.6762576999405443 6 O95197 1 Intraflagellar transport 0.6471479687828265 1.7370802238502858 0.0823730115178542 1.0 0.6840978151665701 12 Q8NCM8,Q9Y496,A0AVF1 3 Neurotransmitter clearance 0.9377990430622012 1.6976701526157942 0.0895700341376646 1.0 0.7202058533649871 2 P21964 1 Ion channel transport 0.5517716555299857 1.6931741640599691 0.0904223207969256 1.0 0.7202058533649871 23 P16615,Q93050,Q9Y487,Q9HD20 4 Cholesterol biosynthesis 0.6068124739897849 1.6615369775064386 0.0966056487894224 1.0 0.7371008855083002 15 Q16850,Q15392,Q15800,Q9BWD1,O75845 5 Role of phospholipids in phagocytosis 0.9278616120721396 1.6567959830521162 0.0975607294301696 1.0 0.7371008855083002 2 Q8IV08 1 Transport of vitamins nucleosides and related molecules 0.736971064764377 1.5957894453507109 0.1105358105590155 1.0 0.7863939254357899 6 P12236,Q8TB61 2 Egr2 and sox10 mediated initiation of schwann cell myelination 0.7363585808918321 1.5932978590223537 0.1110933867632892 1.0 0.7863939254357899 6 Q16850 1 Iron uptake and transport 0.5681360041547371 1.591777643498307 0.1114346751902404 1.0 0.7863939254357899 18 P09601,Q93050,P30519 3 Rhog gtpase cycle 0.5080392865883696 1.57234834971251 0.1158697857294976 1.0 0.8093058880183377 30 Q86XL3,O15173,P50402,Q96JJ3,Q7L576,P34897,P42167,Q14739,O95202 9 Alpha oxidation of phytanate 0.8905568525757415 1.5490330549610478 0.1213737741903673 1.0 0.8134685460183261 4 P51648 1 Rac3 gtpase cycle 0.5060297870150261 1.5071353980558662 0.1317759550705115 1.0 0.8347853525862172 27 O15173,P50402,Q9UQB8,P42167,Q14739 5 Heme degradation 0.8767677341515132 1.4980501705661062 0.1341202159848147 1.0 0.8418052265959339 4 P09601 1 Cytoprotection by hmox1 0.4333544632936469 1.4689470228561936 0.141847159006909 1.0 0.8663490159973547 58 P60900,P20674,P13073,P09601,P30519,P28074,O00231,P00403,P49721 9 Synthesis of pe 0.8778064041221949 1.450519456704332 0.1469137174808177 1.0 0.8708013985309041 2 P35790 1 Metabolism of folate and pterines 0.649382347947361 1.440210537090349 0.1498078429585061 1.0 0.8708013985309041 9 P41440,P34896,Q9H2D1 3 Recruitment of mitotic centrosome proteins and complexes 0.4915878658824923 1.438654609246516 0.1502484057670796 1.0 0.8708013985309041 29 P30153,O94927,O75935,Q9H6D7,Q13561,P41208,Q9BSJ2,O95684,Q15691,Q96CS2,P43034 11 Fcgamma receptor fcgr dependent phagocytosis 0.5004400486402393 1.4215555433826357 0.1551553183866192 1.0 0.8729402629517493 25 Q8IV08,P46108,O43865,Q9UQB8,Q96JJ3,Q7L576 6 Adp signalling through p2y purinoceptor 1 0.8605079131394935 1.3792631774746245 0.1678136253193911 1.0 0.8928209284570733 2 Q16539 1 Initiation of nuclear envelope ne reformation 0.5351945434148724 1.3600734990168704 0.1738066663235347 1.0 0.9116333122898368 17 Q86XL3,Q9Y2U8,P50402,P42167,Q14739 5 Metabolism of cofactors 0.7261322875768864 1.3593777525202813 0.1740269171772082 1.0 0.9116333122898368 5 P35270 1 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.6736217759998906 1.3358121819470836 0.1816106702322404 1.0 0.9164182129791532 6 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.6736217759998906 1.3358121819470836 0.1816106702322404 1.0 0.9164182129791532 6 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Carnitine metabolism 0.7193621599430633 1.3324863291515128 0.1827004308004056 1.0 0.9164182129791532 5 P23786 1 Protein protein interactions at synapses 0.5603205733013723 1.3294870025958676 0.1836873510596981 1.0 0.9164182129791532 13 O95197 1 Metabolism of steroids 0.4484257837697888 1.3102475884849991 0.190112091592322 1.0 0.9357686100935696 38 Q16850,Q15392,Q15800,Q53GQ0,O14734,Q14849,O75845,Q9BWD1,Q14739,P38435 10 Platelet homeostasis 0.6158127519283281 1.2883847624817109 0.197612060262271 1.0 0.9390265966973838 9 P16615,Q16539,Q9UBI6 3 Gamma carboxylation hypusine formation and arylsulfatase activation 0.6355715329447322 1.2846117013345095 0.1989280076233783 1.0 0.9390265966973838 8 Q9BU89,O60725 2 Nr1h2 and nr1h3 mediated signaling 0.8160254610527301 1.2727712509540634 0.2030992256213568 1.0 0.9390265966973838 4 Q8NB78 1 Fceri mediated ca 2 mobilization 0.8336400441663618 1.2688990780661136 0.2044770611951778 1.0 0.9390265966973838 2 O43865 1 Antigen activates b cell receptor bcr leading to generation of second messengers 0.8336400441663618 1.2688990780661136 0.2044770611951778 1.0 0.9390265966973838 2 O43865 1 Pre notch processing in golgi 0.8136669168621327 1.2640206481767848 0.2062226158830926 1.0 0.9390265966973838 4 Q9UBV2 1 Ion transport by p type atpases 0.6561443356260963 1.2634687016334138 0.2064207877270627 1.0 0.9390265966973838 6 Q9HD20 1 Synthesis of very long chain fatty acyl coas 0.6491040291840012 1.2564420848231792 0.2089557313546099 1.0 0.9390265966973838 7 P33121,Q53GQ0 2 Ros and rns production in phagocytes 0.607646572156802 1.2512405347162765 0.2108467335599935 1.0 0.9390265966973838 9 Q93050 1 Regulation of lipid metabolism by pparalpha 0.5342199894975997 1.2250921191516448 0.2205405141584153 1.0 0.9484370536120968 14 P23786,Q15067,P33121 3 Autophagy 0.43707661544862 1.2198289950957404 0.2225297072771828 1.0 0.9484370536120968 38 Q8N4H5,Q15388,Q9NS69,P21796 4 Anchoring of the basal body to the plasma membrane 0.4565803946625176 1.2042259048640078 0.2285022760887092 1.0 0.9546628835362636 30 P30153,O94927,O75935,Q9H6D7,Q13561,P41208,O95684,Q15691,Q96CS2,P43034 10 Insulin receptor recycling 0.5712681608646362 1.1758966144576084 0.2396361919228744 1.0 0.9559459111166424 10 Q93050 1 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.8594037121636576 1.1751349558711297 0.2399407276412637 1.0 0.9559459111166424 3 Q8NB78 1 Peptide hormone metabolism 0.5369210166882433 1.1748895980573206 0.2400388876934878 1.0 0.9559459111166424 12 P67812 1 Peroxisomal lipid metabolism 0.5369194056905333 1.1748812071888122 0.2400422451202128 1.0 0.9559459111166424 12 Q15067,Q9BY49,P51648 3 Aurka activation by tpx2 0.4535564712539129 1.167387068131806 0.2430540911466878 1.0 0.9559459111166424 29 P30153,O94927,O75935,Q9H6D7,Q13561,P41208,O95684,Q15691,Q96CS2,P43034 10 Deubiquitination 0.3888903260097036 1.1651178767349093 0.2439712816015364 1.0 0.9559459111166424 78 P21796,Q8NB78,Q15388,Q96FW1,P28074,Q9Y277,P45880,O00231,P49721 9 Orc1 removal from chromatin 0.4094442790678917 1.1352345082687525 0.256277074404315 1.0 0.9731587037759204 43 P25205,Q9Y619,P28074,Q14566,O00231,P49721 6 Anti inflammatory response favouring leishmania parasite infection 0.5450838841868051 1.1287404698770087 0.2590073318020893 1.0 0.9735831358785966 11 Q16539,O43865 2 Nuclear envelope ne reassembly 0.4041674232690491 1.1262716717930172 0.2600505445925387 1.0 0.9735831358785966 46 Q12769,P30153,Q86XL3,Q8NFH5,Q9Y2U8,Q9BTX1,P02545,P50402,Q92621,P42167,Q14739,Q8N1F7,Q92973 13 Aquaporin mediated transport 0.665806927044948 1.1194897818895235 0.2629312476854972 1.0 0.9757829954976764 5 Q9UBI6,P10644,P13861,Q99797 4 Leishmania infection 0.4313430308126177 1.1051200999321509 0.2691075521833999 1.0 0.9805729675473877 35 P46108,O43865,P09601,Q9UQB8,Q96JJ3,Q16539,Q7L576,Q9UBI6 8 Cellular response to chemical stress 0.3831305625139449 1.104008799515558 0.2695893205840236 1.0 0.9805729675473877 68 P60900,P20674,Q9UL46,P13073,Q8TED1,P09601,P32119,P30519,P28074,P28070,O00231,P00403,P49721 13 Switching of origins to a post replicative state 0.4004541935454118 1.1023798624795345 0.2702965624868583 1.0 0.9805729675473877 49 Q9UJX3,P60900,Q9UL46,P28072,P25205,Q9Y619,P28074,Q9H1A4,P28070,Q14566,O00231,P20618,P49721 13 Uch proteinases 0.4111395662427308 1.0888016463123644 0.2762413654823681 1.0 0.9805729675473877 41 Q8NB78,O00231,P28074,P49721 4 Copi dependent golgi to er retrograde traffic 0.3994521428959195 1.0868635654044458 0.2770971103899793 1.0 0.9805729675473877 47 Q9Y496,P24390,Q9H0B6,Q9P2W9,Q12981 5 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6072386961260079 1.081063143673172 0.2796690266379664 1.0 0.9824085944257012 7 Q15067,P33121 2 Dopamine neurotransmitter release cycle 0.7865292602134734 1.0773414823518634 0.2813277364633042 1.0 0.9824085944257012 2 O14936 1 Nicotinate metabolism 0.8321392458895748 1.0766377392849231 0.2816421372829478 1.0 0.9824085944257012 3 P43490 1 Disorders of transmembrane transporters 0.3805313796012607 1.075785166032823 0.2820233479820988 1.0 0.9824085944257012 69 Q12769,P60900,Q9UL46,P28072,Q9UBV2,Q9BTX1,O00231,Q9BUN8,P28074,P28070,P49721,P53985,P20618,Q8N1F7,Q8NFH5 15 Tysnd1 cleaves peroxisomal proteins 0.6547946740337109 1.0757753831140229 0.2820277242440889 1.0 0.9824085944257012 5 Q15067 1 Depolymerisation of the nuclear lamina 0.5684339071581432 1.0721527821645338 0.2836514146194757 1.0 0.9830362002842898 9 P42167,P50402,Q9Y2U8 3 Metabolism of lipids 0.3645101083660241 1.0611702681790405 0.2886125285851013 1.0 0.9876639797309248 157 P23786,Q8IV08,Q16850,Q06136,Q15392,Q15800,Q10713,P43304,O75845,P33121,Q9NPH0,P35790,O15269,Q96G23,Q71SY5,Q53GQ0,O43772,P48651,Q9NUQ2,P38435,P51648,Q9NZJ7,P42356,O14734,Q8NCC3,Q15067,Q15165,Q14739,O95470,Q96N66,Q9BY49,Q9BWD1,Q9H7Z7,O00116,Q14849,Q16739 36 Response to elevated platelet cytosolic ca2 0.4411095098901983 1.0530537226070102 0.292316370831938 1.0 0.992855104920448 27 Q8NBF2,Q9NTK5,O94919,Q8NBX0,O43852 5 Activation of smo 0.7754876702245153 1.0330225580859955 0.3015933421127528 1.0 1.0 2 Q9Y496 1 Recruitment of numa to mitotic centrosomes 0.4260817817042199 1.0267885387181397 0.3045200473985348 1.0 1.0 33 P30153,O94927,O75935,Q9H6D7,Q13561,P41208,Q9BSJ2,O95684,Q15691,Q96CS2,P43034 11 Linoleic acid la metabolism 0.7736474052263553 1.0256639575250606 0.3050500089537036 1.0 1.0 2 P33121 1 Acyl chain remodelling of pc 0.771071034228932 1.01537620450034 0.3099265315023711 1.0 1.0 2 Q8NF37 1 Signaling by cytosolic fgfr1 fusion mutants 0.5924578852153075 0.9994276385754304 0.3175875765491183 1.0 1.0 6 O95684,P62993,P42224 3 Creb phosphorylation 0.7659182922340848 0.9948527276755424 0.3198078971340288 1.0 1.0 2 P51812 1 Interleukin 4 and interleukin 13 signaling 0.5024139018066283 0.9945950043466716 0.3199332781844015 1.0 1.0 12 P08670,P09601 2 Metalloprotease dubs 0.6337509211495992 0.9925171477042976 0.3209453188049762 1.0 1.0 5 O00487,Q9NWV8,Q15018,Q92783 4 Synthesis of pips at the er membrane 0.80338733431517 0.973877037102178 0.3301175965500458 1.0 1.0 3 Q9NTJ5,P42356 2 Fgfr1 mutant receptor activation 0.5810672609955783 0.9715170160636848 0.3312908837896098 1.0 1.0 7 O95684,P62993,P42224 3 Signaling by fgfr1 in disease 0.5810672609955783 0.9715170160636848 0.3312908837896098 1.0 1.0 7 O95684,P62993,P42224 3 Wax and plasmalogen biosynthesis 0.7978645066273939 0.9543088828792896 0.3399273129567539 1.0 1.0 3 Q6IAN0,O00116 2 Defective cftr causes cystic fibrosis 0.403369544455768 0.947734445839411 0.3432646604417531 1.0 1.0 38 P60900,Q9UL46,Q9UBV2,Q9BUN8,P28074,P28070,O00231,P20618,P49721 9 Rho gtpase cycle 0.3451565827306649 0.945914984097518 0.3441919502090065 1.0 1.0 132 Q13505,Q9UDY2,Q07065,Q96JJ3,P42167,P41440,Q5JTV8,P51572,P08670,Q86XL3,O15173,P50402,Q9UQB8,P30519,P51648,P38159,Q14739,O95202,Q5VTR2,O75323,Q7L576,P34897,Q96HY6,Q9BT78 24 Tp53 regulates metabolic genes 0.4208162596080492 0.9419138819330266 0.3462367322665607 1.0 1.0 30 P20674,P13073,Q9HCE1,P11413,P00403 5 Rora activates gene expression 0.7508281192491753 0.9351858256768038 0.3496925419907795 1.0 1.0 2 P50416 1 Cdt1 association with the cdc6 orc origin complex 0.4085230078554571 0.9270872500445873 0.3538812354268452 1.0 1.0 35 P60900,Q9UL46,P28072,Q9Y619,P28074,P28070,O00231,P20618,P49721 9 Metabolism of steroid hormones 0.5703666840422367 0.908398787297847 0.3636675662253581 1.0 1.0 6 Q14849,Q53GQ0 2 Pyruvate metabolism and citric acid tca cycle 0.4142603911832898 0.9065679448216148 0.3646353194313607 1.0 1.0 31 P53985,P48735,Q13423 3 Complex i biogenesis 0.4339526650957745 0.9002808721005954 0.3679707977398512 1.0 1.0 22 P03886,O96000,O43676,Q9NPL8,Q9NX14 5 Striated muscle contraction 0.6101011582478428 0.8996371991149171 0.3683133541420549 1.0 1.0 5 P08670,Q9NYL9 2 Antigen processing cross presentation 0.3784489164527265 0.8965673731176821 0.3699498145062676 1.0 1.0 46 P60900,P10321,Q9UL46,Q9UIQ6,P28074,Q03518,P28070,O00231,P20618,P49721 10 Receptor type tyrosine protein phosphatases 0.739786529260217 0.8919930303719944 0.3723966681187232 1.0 1.0 2 Q13136 1 Hedgehog off state 0.3764719945809979 0.8818202169861661 0.3778740370038802 1.0 1.0 48 P60900,Q9Y496,Q9UL46,P28072,P04350,P28074,P28070,Q8NCM8,O00231,P20618,P49721 11 Dap12 interactions 0.7767138197356067 0.8800004928573387 0.3788590425588896 1.0 1.0 3 P10321 1 Pyruvate metabolism 0.4707464549037201 0.8766581763830489 0.3806723299801466 1.0 1.0 14 P53985 1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.7072457871276869 0.873780736171447 0.3822376731875587 1.0 1.0 4 P12236 1 Cytochrome p450 arranged by substrate type 0.7739981771408745 0.8705403585102549 0.3840051737156797 1.0 1.0 3 Q16850 1 Signaling by hedgehog 0.3726287784983267 0.862045195550447 0.3886626477441461 1.0 1.0 53 Q9Y496,Q9UBV2,P28074,Q8NCM8,O00231,P49721 6 Abc transporter disorders 0.3874321204535525 0.8395981874114344 0.4011337158842143 1.0 1.0 39 P60900,Q9UL46,Q9UBV2,Q9BUN8,P28074,P28070,O00231,P20618,P49721 9 Formation of atp by chemiosmotic coupling 0.5170291913941761 0.8374559073285064 0.402336351514803 1.0 1.0 9 P24539,P56385,O75964 3 Phase ii conjugation of compounds 0.4120704722629085 0.8370765304311604 0.402549551675913 1.0 1.0 26 Q9NUJ1,P21964,Q99735,P21266,Q8TB61 5 Abc family proteins mediated transport 0.3714548211609483 0.8336522347288267 0.4044769816388529 1.0 1.0 46 P60900,P08183,Q9UL46,P40855,Q9UBV2,Q9BUN8,P28074,P28070,O00231,P20618,P49721 11 Regulation of plk1 activity at g2 m transition 0.3990087639374639 0.8054377789658222 0.4205670982658085 1.0 1.0 32 P30153,O94927,O75935,Q9H6D7,Q13561,P41208,O95684,Q15691,Q96CS2,P43034 10 Intra golgi traffic 0.5404317231476569 0.8028676324103005 0.4220512459921564 1.0 1.0 7 O00461 1 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.4571255164493149 0.8018057843808972 0.4226653121227337 1.0 1.0 14 O76024,Q13217,Q07065,Q02818,O43852 5 Incretin synthesis secretion and inactivation 0.6869947383956677 0.8016976281575462 0.4227278881618035 1.0 1.0 4 P67812 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.6869947383956677 0.8016976281575462 0.4227278881618035 1.0 1.0 4 P67812 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.4608556423363492 0.7980525947852671 0.424839969488425 1.0 1.0 13 P51572,P10321,Q9NZ08,Q03518 4 Ethanol oxidation 0.7529262460896036 0.7978623775557683 0.4249503581366125 1.0 1.0 3 P05091 1 Metabolism of nitric oxide nos3 activation and regulation 0.5430252767884882 0.7968900457690161 0.4255148925318366 1.0 1.0 6 P35270 1 Regulation of hmox1 expression and activity 0.3763763624633325 0.7941711070588378 0.4270958263701474 1.0 1.0 41 P60900,Q9UL46,P09601,P28074,P28070,O00231,P20618,P49721 8 Frs mediated fgfr2 signaling 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr2 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Frs mediated fgfr1 signaling 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr1 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Frs mediated fgfr3 signaling 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Tie2 signaling 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr2 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Stat5 activation 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr3 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Stat5 activation downstream of flt3 itd mutants 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Signaling by flt3 itd and tkd mutants 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr1 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Frs mediated fgfr4 signaling 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr4 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr4 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Activated ntrk2 signals through frs2 and frs3 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr3 0.7132867132867173 0.7902697659302302 0.429370239773206 1.0 1.0 2 P62993 1 Activation of irf3 irf7 mediated by tbk1 ikk epsilon 0.7132867132867171 0.7902697659302282 0.4293702397732071 1.0 1.0 2 Q9UHD2 1 Cardiac conduction 0.5219237591990571 0.7890765085158313 0.4300672910407803 1.0 1.0 8 O43865 1 Ion homeostasis 0.5219237591990571 0.7890765085158313 0.4300672910407803 1.0 1.0 8 O43865 1 Disinhibition of snare formation 0.7129186602870854 0.7888787910577505 0.4301828527669604 1.0 1.0 2 O00186 1 Ire1alpha activates chaperones 0.4247456270371715 0.7882647246907782 0.4305418766613971 1.0 1.0 20 O76024,P43307 2 Activation of atr in response to replication stress 0.447936419019263 0.7775830993615476 0.4368148275979746 1.0 1.0 15 Q9Y619,Q14566 2 Rhoa gtpase cycle 0.3838471289834637 0.7685924075375961 0.4421353141449404 1.0 1.0 37 Q96HY6,O15173,P30519,P42167,Q14739,P41440 6 Rhod gtpase cycle 0.4077567210157509 0.7624372733033249 0.4457990673094363 1.0 1.0 24 O15173,P50402,P42167,Q14739,Q5JTV8 5 Glycogen storage diseases 0.7367696987636617 0.7431307358927967 0.4574025328062683 1.0 1.0 3 Q04446 1 Arms mediated activation 0.6996687523003354 0.7392554275448898 0.4597519093830144 1.0 1.0 2 P46108 1 Ptk6 regulates proteins involved in rna processing 0.7323948860289471 0.728478699719451 0.4663206029142863 1.0 1.0 3 O75525 1 Glucagon signaling in metabolic regulation 0.6655616942909679 0.7267595537233393 0.4673732641271952 1.0 1.0 4 Q9UBI6,P10644,P13861 3 Vasopressin regulates renal water homeostasis via aquaporins 0.6655616942909679 0.7267595537233393 0.4673732641271952 1.0 1.0 4 Q9UBI6,P10644,P13861 3 Fcgr3a mediated il10 synthesis 0.6655616942909487 0.7267595537232729 0.4673732641272359 1.0 1.0 4 P10644,P13861,O43865 3 Synthesis of ip2 ip and ins in the cytosol 0.6956201693043842 0.7242776384465597 0.4688953024833893 1.0 1.0 2 Q01968 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7247019384455905 0.7029019374433867 0.4821168636739037 1.0 1.0 3 P67812 1 Synthesis secretion and deacylation of ghrelin 0.7247019384455905 0.7029019374433867 0.4821168636739037 1.0 1.0 3 P67812 1 Metabolism of vitamins and cofactors 0.3678770827418853 0.698837464024935 0.484653612630074 1.0 1.0 40 Q4G0N4,O75874,Q9H2D1,P43490,P34896,Q96EY8,Q8N0U8,P35270,Q9NRN7,P41440,P78417 11 Apc c cdc20 mediated degradation of cyclin b 0.5000987843752567 0.6957569216510728 0.4865810713956464 1.0 1.0 8 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Signal amplification 0.5561950406451305 0.6928771640460444 0.4883866417290874 1.0 1.0 5 Q16539 1 Signaling by ntrk2 trkb 0.6545119705340717 0.6887762050826158 0.4909641119074657 1.0 1.0 4 Q00535,Q06124,P62993 3 Processing of smdt1 0.4688339295651229 0.6873826265753742 0.4918416427886996 1.0 1.0 10 Q9Y4W6,P35232,Q10713 3 Gpcr ligand binding 0.494159466091277 0.6706251626488627 0.502459348560268 1.0 1.0 8 Q9NZJ7,Q9BYT8 2 Regulation of ifng signaling 0.7135493372606785 0.666277681981103 0.5052336280779175 1.0 1.0 3 P18031,P42224 2 Regulation of ifna signaling 0.7135493372606785 0.666277681981103 0.5052336280779175 1.0 1.0 3 P18031,P42224 2 Slc transporter disorders 0.3834942898509786 0.6655836813730583 0.5056772397806668 1.0 1.0 30 Q12769,P53985,Q8N1F7,Q9BTX1 4 Sulfur amino acid metabolism 0.4498335397185797 0.6547353900784035 0.512638135474685 1.0 1.0 11 Q9UBX3 1 Signaling by flt3 fusion proteins 0.709823121624582 0.6541685790875742 0.5130032024527467 1.0 1.0 3 P62993 1 Ub specific processing proteases 0.3440850983980543 0.6455116956750122 0.5185956415042834 1.0 1.0 63 P60900,P28070,Q9UL46,P21796,Q15388,P51784,Q96FW1,P28074,Q9Y277,P45880,P49721,O00231,P20618,Q9UPU5 14 O linked glycosylation 0.7005032255369202 0.6241794864770625 0.5325097171677828 1.0 1.0 3 O43505 1 O linked glycosylation of mucins 0.7005032255369202 0.6241794864770625 0.5325097171677828 1.0 1.0 3 O43505 1 Collagen biosynthesis and modifying enzymes 0.4680330106460891 0.6180634301178883 0.5365335273494904 1.0 1.0 9 Q32P28 1 Robo receptors bind akap5 0.6650717703349331 0.61446575998333 0.5389075924982376 1.0 1.0 2 P13861 1 Hedgehog ligand biogenesis 0.3640311557430158 0.6088657796521859 0.5426134082410798 1.0 1.0 37 P60900,Q9UL46,P28072,Q9UBV2,P28074,P28070,O00231,P20618,P49721 9 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.5305006010364501 0.5981734820993511 0.549724183486598 1.0 1.0 5 Q96JJ3 1 Activation of bad and translocation to mitochondria 0.4870943952802433 0.5879960044724072 0.5565349746922981 1.0 1.0 7 Q9Y3B8,P27348,P31946,Q04917,P62258,P61981 6 Mitotic g2 g2 m phases 0.3357748612681513 0.5876657974780957 0.5567566371521329 1.0 1.0 79 P60900,P41208,Q9BSJ2,Q15691,P43034,O94927,O75935,Q99640,Q9H6D7,Q13561,P04350,Q96CS2,P30153,Q9UL46,P28074,P20618,P49721,O95684,P28070,O00231,P28072 21 Synthesis of pc 0.623744643814657 0.5858613104103751 0.5579687187406819 1.0 1.0 4 P35790,Q8NF37 2 Assembly of the hiv virion 0.6566065513433984 0.5851587061478036 0.5584410079150786 1.0 1.0 2 Q99816 1 Neuronal system 0.3436958733962864 0.5843642354626055 0.5589752834715953 1.0 1.0 45 P21964,P10644,P10586,P53680,Q13136,Q13885,P05091,O95197,O75915,O14936,P04350,P51812,P41440,Q9UBI6,Q15418 15 Citric acid cycle tca cycle 0.4034256308874547 0.5784980764556323 0.5629278956859278 1.0 1.0 17 P48735,Q13423 2 Activated ntrk2 signals through cdk5 0.6540301803459749 0.5763463910904653 0.5643810720065283 1.0 1.0 2 Q00535 1 Phenylalanine metabolism 0.6525579683474472 0.5713339289373689 0.5677733067572053 1.0 1.0 2 Q7L266 1 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.4568657752025927 0.5693096258435048 0.5691460355212525 1.0 1.0 9 P09601 1 Flt3 signaling in disease 0.6154366978295832 0.5589020454193653 0.5762285734003811 1.0 1.0 4 Q14789,P62993 2 Constitutive signaling by akt1 e17k in cancer 0.6459330143540722 0.5489914375749635 0.5830113259300111 1.0 1.0 2 P49840 1 Transcriptional regulation by ventx 0.4365690239531146 0.5381982631486693 0.5904401790135032 1.0 1.0 10 Q9UJX3,P30260,P35222,Q9HCE1,Q9H1A4,Q9UJX2 6 Vxpx cargo targeting to cilium 0.4618222058281004 0.536505350382308 0.5916093391465691 1.0 1.0 8 P18085,Q92538,Q8TAG9,O00471,P61006,O60645,Q9UPT5 7 Glycogen synthesis 0.5132189505695065 0.5364658316771053 0.591636644270159 1.0 1.0 5 Q04446 1 Transferrin endocytosis and recycling 0.4239290149570346 0.5296627502933334 0.5963457788586362 1.0 1.0 11 Q93050 1 Pka activation in glucagon signalling 0.6653166421207671 0.5152848479984975 0.6063539854427327 1.0 1.0 3 P10644,P13861 2 Pka mediated phosphorylation of creb 0.6653166421207671 0.5152848479984975 0.6063539854427327 1.0 1.0 3 P10644,P13861 2 Creb1 phosphorylation through the activation of adenylate cyclase 0.6653166421207671 0.5152848479984975 0.6063539854427327 1.0 1.0 3 P10644,P13861 2 Platelet sensitization by ldl 0.5070920664490102 0.5150390637821486 0.6065257228669172 1.0 1.0 5 Q16539 1 Pre notch expression and processing 0.4310671269590441 0.5132923569621404 0.6077468295476653 1.0 1.0 10 P16615,Q9UBV2 2 Methylation 0.4532856847944251 0.5020480021497042 0.6156337554512756 1.0 1.0 8 P21964 1 Notch3 activation and transmission of signal to the nucleus 0.6601542915454361 0.4999537165463013 0.6171076674275553 1.0 1.0 3 P67809 1 Activation of the pre replicative complex 0.3921775638864253 0.4886486265330887 0.6250904805195159 1.0 1.0 16 Q9Y619,Q14566 2 G2 m checkpoints 0.3255074268123357 0.4838366665233816 0.6285017907269861 1.0 1.0 73 Q9UQ84,P25205,Q9Y619,P28074,Q14566,O00231,P49721 7 Synthesis of pips at the golgi membrane 0.4612702562497862 0.479760407433162 0.6313977687298058 1.0 1.0 6 Q10713,P42356 2 Glycogen metabolism 0.4191691239856247 0.4601150080744626 0.6454336721218243 1.0 1.0 10 P13807,Q04446 2 Signaling by vegf 0.3633385072938195 0.4472732794233938 0.6546777574386111 1.0 1.0 23 O43865,Q9UQB8,Q96JJ3,Q16539,Q7L576 5 Regulation of localization of foxo transcription factors 0.4867354458364152 0.4457824354125564 0.6557544107231814 1.0 1.0 5 P61981,Q9Y3B8,P27348,P31946 4 Degradation of axin 0.3485532365869219 0.4453666853671408 0.6560547835696218 1.0 1.0 34 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Regulation of runx3 expression and activity 0.3485532365869219 0.4453666853671408 0.6560547835696218 1.0 1.0 34 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Cross presentation of soluble exogenous antigens endosomes 0.3485532365869219 0.4453666853671408 0.6560547835696218 1.0 1.0 34 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Hedgehog on state 0.3389291389763358 0.4391680069387904 0.6605398049805693 1.0 1.0 39 P60900,Q9Y496,Q9UL46,P28074,P28070,O00231,P20618,P49721 8 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3762840172002527 0.4390705507692955 0.6606104168681597 1.0 1.0 18 Q86YN1 1 Traf6 mediated irf7 activation 0.6384388807069231 0.4375230074669868 0.6617320942650857 1.0 1.0 3 Q9UHD2,Q7Z434 2 Traf3 dependent irf activation pathway 0.6384388807069231 0.4375230074669868 0.6617320942650857 1.0 1.0 3 Q9UHD2,Q7Z434 2 Hiv transcription initiation 0.4256617366825359 0.4369858819428718 0.6621215868122645 1.0 1.0 9 Q92804,P18074,P29083 3 Signaling by notch3 0.4831456681087041 0.4339052450264445 0.6643572508089433 1.0 1.0 5 P67809,P42224 2 Peptide ligand binding receptors 0.4483496859082677 0.4333065159655487 0.6647921050001089 1.0 1.0 6 Q9BYT8 1 Class a 1 rhodopsin like receptors 0.4483496859082677 0.4333065159655487 0.6647921050001089 1.0 1.0 6 Q9BYT8 1 Signaling by hippo 0.4461651917404217 0.4326847803389285 0.6652437881704172 1.0 1.0 7 Q07157,Q9UDY2,O14641,P31946,Q4VCS5,P62258 6 Mitotic metaphase and anaphase 0.3058591240990442 0.4310407740499144 0.6664387233592683 1.0 1.0 120 Q12769,P60900,Q8NBT2,Q15005,Q29RF7,Q92621,Q15691,P42167,P43034,Q8N1F7,Q14674,Q9UJX3,Q86XL3,Q9Y2U8,Q9BTX1,P02545,P50402,P04350,Q92973,Q8NFH5,P30153,Q9UL46,P28074,Q9H1A4,Q14739,P20618,P49721,Q7Z5K2,P28070,O00231,P28072 31 Transcriptional activation of mitochondrial biogenesis 0.4109401995980493 0.4239518849870167 0.6716009036016701 1.0 1.0 10 Q8WVM0,P48735,P06576 3 Carboxyterminal post translational modifications of tubulin 0.4440705562114841 0.4182257014090588 0.6757821061832168 1.0 1.0 6 Q13885,Q14166,P04350 3 Beta catenin phosphorylation cascade 0.4776558514134822 0.4159522589177236 0.6774449379947658 1.0 1.0 5 P30153,P48729 2 Signaling by ctnnb1 phospho site mutants 0.4776558514134822 0.4159522589177236 0.6774449379947658 1.0 1.0 5 P30153,P48729 2 Class i mhc mediated antigen processing presentation 0.3184163736704641 0.411120550277855 0.6809841419228646 1.0 1.0 95 P60900,Q9NWX5,P52888,P55786,P51572,Q9Y6B6,Q9UJX3,Q03518,P10321,Q9UL46,Q9UIQ6,P28074,Q9H1A4,P20618,P19474,P49721,Q9NZ08,Q9BSL1,P28070,O00231,P28072 21 Pi3k akt signaling in cancer 0.4398327248287839 0.4097322099750319 0.6820023992677853 1.0 1.0 7 P62993,Q06124,P63000,O43815,P49840 5 Postmitotic nuclear pore complex npc reformation 0.3587869266604169 0.4066933682321613 0.6842332118891408 1.0 1.0 22 Q92973,Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 6 Miscellaneous transport and binding events 0.6222385861561129 0.3933015028720082 0.6940968083635344 1.0 1.0 3 Q9UNS2,Q9UEY8 2 Rac1 gtpase cycle 0.3435562463409087 0.3882539465030283 0.6978281146070313 1.0 1.0 32 P42167,Q14739,P50402,Q9UQB8 4 Regulation of ras by gaps 0.3395337447592612 0.3877532669265618 0.6981986324369864 1.0 1.0 35 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Signaling by ptk6 0.3798190052996588 0.3703946991761435 0.7110884228502448 1.0 1.0 12 P18031,P46108,O75525,Q96JJ3 4 Golgi to er retrograde transport 0.3133781927987765 0.3663305022613953 0.7141184716115627 1.0 1.0 69 Q9Y496,O75935,Q92538,P24390,Q9H0B6,Q13561,Q9BVK6,O15260,Q9P2W9,Q9Y678,Q12981,Q9UJW0,Q10472,P43034 14 Fgfr2 alternative splicing 0.3769401330376977 0.3639074043942923 0.7159271553098325 1.0 1.0 13 P13984,P62487,P09651,Q09161,P31943,Q01085,P19387,P30876,P26599,P62875,P52597,P24928 12 Regulation of signaling by cbl 0.6099474966229794 0.3612145535453401 0.7179390634209377 1.0 1.0 3 P46108 1 Signaling by fgfr in disease 0.3740035093889878 0.3591421295856565 0.7194887662509266 1.0 1.0 14 O95684,P62993,P42224 3 Interleukin 3 interleukin 5 and gm csf signaling 0.4261669970440168 0.3569503261880303 0.7211289931681031 1.0 1.0 6 P46108 1 Formation of the early elongation complex 0.3855243722304287 0.3524652241875813 0.7244893942940696 1.0 1.0 11 P13984,Q8IXH7,P62487,P18074,O00267,Q8WX92,P19387,P30876,P62875,P24928 10 Traf6 mediated nf kb activation 0.5454880294659405 0.3504507259570837 0.726000463210847 1.0 1.0 4 Q14258,Q7Z434,Q00653 3 Metabolism of polyamines 0.3330535116472108 0.3496126330404728 0.7266294287740358 1.0 1.0 36 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Retrograde neurotrophin signalling 0.4222339357676969 0.3478116735508617 0.7279816221789774 1.0 1.0 7 P53680 1 Degradation of dvl 0.3323107379195479 0.3438841569716396 0.7309334069771065 1.0 1.0 36 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Cdc42 gtpase cycle 0.3480696805140851 0.3388275961621292 0.7347396109473219 1.0 1.0 22 P42167,Q9UQB8 2 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.3214960959274473 0.330127931329197 0.741303299073959 1.0 1.0 41 Q9UJX3,P60900,Q9UL46,P28072,P49720,P28074,Q9H1A4,P28070,O00231,P20618,P49721 11 Regulation of runx2 expression and activity 0.3271814503342191 0.3294575502919831 0.7418098745197241 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P42224,P28070,O00231,P20618,P49721 9 Intra golgi and retrograde golgi to er traffic 0.3125747546644385 0.3279539648840892 0.7429464699776516 1.0 1.0 84 P24390,Q9BVK6,O15260,P43034,Q9Y496,O75935,Q92538,Q13561,Q8TBA6,Q9P2W9,Q9Y678,Q12981,Q9H0B6,Q9UJW0,Q7Z6M1,O00461,Q5VZE5,Q10472,Q5VIR6 19 Asymmetric localization of pcp proteins 0.3300381145984646 0.326396936476264 0.7441240550673451 1.0 1.0 36 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Interferon gamma signaling 0.3969893601398128 0.3222819686138646 0.747239091973428 1.0 1.0 9 P18031,P10321,P19474 3 Signaling by the b cell receptor bcr 0.3198091709451238 0.3161970306813618 0.751852961395858 1.0 1.0 41 P60900,P62993,O43865,Q9UL46,P28074,P28070,O00231,P20618,P49721 9 Abortive elongation of hiv 1 transcript in the absence of tat 0.3853820598006656 0.3155476709351683 0.7523458621442884 1.0 1.0 10 P13984,Q8IXH7,P62487,O00267,Q8WX92,P19387,P30876,P62875,P24928 9 Regulation of glucokinase by glucokinase regulatory protein 0.3390751022370309 0.31207811210441 0.7549811604313235 1.0 1.0 25 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Sumoylation of sumoylation proteins 0.3390751022370309 0.31207811210441 0.7549811604313235 1.0 1.0 25 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Sumoylation of ubiquitinylation proteins 0.3390751022370309 0.31207811210441 0.7549811604313235 1.0 1.0 25 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 The canonical retinoid cycle in rods twilight vision 0.5653294074346772 0.3108863103631583 0.7558870519110299 1.0 1.0 2 P09455 1 Nuclear envelope breakdown 0.3244009974787342 0.307522530753478 0.7584456762839218 1.0 1.0 38 Q12769,Q9Y2U8,Q9BTX1,P02545,P50402,Q92621,P42167,Q8N1F7,Q8NFH5 9 Parasite infection 0.3474494795576136 0.306925139243501 0.7589003536516659 1.0 1.0 20 P46108,Q7L576,Q9UQB8,Q96JJ3 4 Copi mediated anterograde transport 0.313023985709313 0.3058420076972866 0.7597249424701789 1.0 1.0 48 Q14789,O75935,Q92538,Q12955,P24390,Q13561,Q9BVK6,Q9Y678,Q9UJW0 9 Cd209 dc sign signaling 0.561280824438726 0.3008432793559913 0.7635340041124057 1.0 1.0 2 P17612 1 Nef and signal transduction 0.5612808244387246 0.3008432793559878 0.7635340041124083 1.0 1.0 2 P63000 1 Ephrin signaling 0.5612808244387246 0.3008432793559878 0.7635340041124083 1.0 1.0 2 P63000 1 Cellular response to hypoxia 0.3262891512479526 0.2976895422410172 0.7659401258483243 1.0 1.0 36 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Regulation of pten stability and activity 0.3216857335638632 0.2862005101623407 0.774724553027103 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Activated notch1 transmits signal to the nucleus 0.5542878174457191 0.2839816727170463 0.7764244257495534 1.0 1.0 2 Q96J02 1 Mrna capping 0.3852398523985285 0.2777494603038853 0.7812046899436051 1.0 1.0 9 P13984,P62487,P18074,O00267,P19387,P30876,P62875,P24928 8 Chromatin modifying enzymes 0.3100378264445858 0.2774923091486203 0.781402110455474 1.0 1.0 56 Q8NB78 1 Scf skp2 mediated degradation of p27 p21 0.3205751936662785 0.2652741156410561 0.7907983031367969 1.0 1.0 37 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Cyclin a cdk2 associated events at s phase entry 0.3205751936662785 0.2652741156410561 0.7907983031367969 1.0 1.0 37 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Diseases of immune system 0.5450864924549204 0.2627492429860055 0.792743859423277 1.0 1.0 2 Q00653 1 Sumoylation of rna binding proteins 0.3287229123217107 0.2604097330962351 0.7945477359574107 1.0 1.0 28 Q12769,Q9BTX1,Q92621,P61978,Q8N1F7,Q8NFH5 6 Energy dependent regulation of mtor by lkb1 ampk 0.5670103092783518 0.2601248458506868 0.7947674732230439 1.0 1.0 3 P42345,Q9Y376 2 Disassembly of the destruction complex and recruitment of axin to the membrane 0.3945870847554436 0.2571551445903612 0.7970590092410066 1.0 1.0 6 P30153,P48729 2 Signaling by notch 0.3078955074742774 0.2562194447164714 0.7977813949412855 1.0 1.0 55 P60900,P28070,Q9UL46,P28072,Q9UBV2,Q9HCE1,P67809,P28074,P42224,P16615,O00231,P20618,P49721 13 Regulation of mecp2 expression and activity 0.3871997562403459 0.2557721448164682 0.7981267838324557 1.0 1.0 8 Q14739 1 Transcriptional regulation of white adipocyte differentiation 0.4237863194186608 0.2555416596627287 0.7983047716079399 1.0 1.0 5 Q71SY5 1 Regulation of insulin secretion 0.3627922188735747 0.2545334364476866 0.799083475919866 1.0 1.0 11 O43865 1 N glycan trimming in the er and calnexin calreticulin cycle 0.3519905942305173 0.2511441512379637 0.8017026617511265 1.0 1.0 14 Q9UBV2 1 Signaling by fgfr2 in disease 0.385097749907783 0.2487007941025952 0.8035922345322319 1.0 1.0 8 P13984,P62993,P62487,P19387,P30876,P62875,P24928 7 Regulation of innate immune responses to cytosolic dna 0.5001857669208843 0.23822491399557 0.811706654705032 1.0 1.0 4 P19474 1 Constitutive signaling by aberrant pi3k in cancer 0.4167871202686655 0.2371071708081505 0.8125736494751248 1.0 1.0 5 O43815,P62993 2 Smac xiap regulated apoptotic response 0.5329407434670663 0.2364172767541719 0.813108891214517 1.0 1.0 2 P98170 1 Rho gtpases activate wasps and waves 0.344999254890691 0.2349642867491522 0.8142364523326342 1.0 1.0 16 Q9UQB8 1 Irf3 mediated activation of type 1 ifn 0.5318365844681707 0.2341203755760661 0.8148915280386491 1.0 1.0 2 Q9UHD2 1 Signaling by insulin receptor 0.3462664821365797 0.2311865128683907 0.8171699073927696 1.0 1.0 15 Q93050 1 Stabilization of p53 0.3174640055114521 0.2308959781892476 0.8173956152649235 1.0 1.0 36 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Unwinding of dna 0.3640246663341372 0.2305850311582097 0.8176371976690389 1.0 1.0 10 Q14566 1 Gab1 signalosome 0.4966152538312174 0.2302948777256595 0.8178626406381955 1.0 1.0 4 Q06124,P62993 2 Signaling by fgfr2 iiia tm 0.3849557522123984 0.2274607620644668 0.8200654769318625 1.0 1.0 7 P13984,P62487,P19387,P30876,P62875,P24928 6 Fgfr2 mutant receptor activation 0.3849557522123984 0.2274607620644668 0.8200654769318625 1.0 1.0 7 P13984,P62487,P19387,P30876,P62875,P24928 6 Diseases of mitotic cell cycle 0.3713753148877282 0.2273973003643137 0.820114819306689 1.0 1.0 9 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Signaling by pdgf 0.3836034601935669 0.2253012833155433 0.8217449013927594 1.0 1.0 6 P46108,P62993 2 Downstream signal transduction 0.3836034601935669 0.2253012833155433 0.8217449013927594 1.0 1.0 6 P46108,P62993 2 Nef mediated cd8 down regulation 0.4112011790714884 0.2228400176929999 0.8236600213810932 1.0 1.0 5 Q9UI12,Q96CW1,O94973,P53680 4 Nef mediated cd4 down regulation 0.4112011790714884 0.2228400176929999 0.8236600213810932 1.0 1.0 5 Q9UI12,Q96CW1,O94973,P53680 4 Transcriptional regulation by runx2 0.3024774770172913 0.2185359381573775 0.8270115603143808 1.0 1.0 46 P60900,Q9UL46,P28072,Q96PK6,P49720,P28074,P42224,P28070,O00231,P20618,P49721 11 Mapk family signaling cascades 0.302115537878226 0.2161424427813972 0.8288767169864042 1.0 1.0 80 P49356,P30153,P60900,P28070,P62993,Q9UL46,P28072,Q9HCE1,O43924,P28074,P30086,O60725,O00231,P20618,P49721 15 Nuclear events kinase and transcription factor activation 0.3452578672656404 0.2139993295727726 0.8305475799941611 1.0 1.0 12 Q16539,P50570,P51812 3 Degradation of gli1 by the proteasome 0.3123086217827572 0.2134229779342265 0.8309970595467044 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Beta oxidation of very long chain fatty acids 0.3727779854520118 0.1955081091976595 0.8449951899536607 1.0 1.0 6 Q15067 1 Pregnenolone biosynthesis 0.4796485703245318 0.1945748653969317 0.8457257814658212 1.0 1.0 4 Q14849 1 Formyl peptide receptors bind formyl peptides and many other ligands 0.5079131394920944 0.1883731348020864 0.8505841580138633 1.0 1.0 2 Q9NRV9 1 Negative regulation of notch4 signaling 0.3090326961974395 0.188354594839978 0.8505986906471317 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Dna replication pre initiation 0.3004207199050961 0.1872054179249003 0.8514995770475164 1.0 1.0 55 P25205,Q9Y619,P28074,Q14566,O00231,P49721 6 Export of viral ribonucleoproteins from nucleus 0.3168144360482523 0.1788638048064288 0.8580446439935574 1.0 1.0 27 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Antigen processing ubiquitination proteasome degradation 0.2975581219549506 0.1759910210579437 0.8603009965078499 1.0 1.0 76 Q9UJX3,P60900,P28070,Q9NWX5,Q9UL46,P28072,Q9UIQ6,P28074,Q9BSL1,Q9H1A4,P52888,P49721,O00231,P20618,P19474,P55786 16 Platelet aggregation plug formation 0.3652195895973731 0.175696578182872 0.8605323237023184 1.0 1.0 6 P18031,P46108 2 Integrin signaling 0.3652195895973731 0.175696578182872 0.8605323237023184 1.0 1.0 6 P18031,P46108 2 Hur elavl1 binds and stabilizes mrna 0.3909358879882147 0.1745462905661075 0.8614361544593092 1.0 1.0 5 O14980,P35658,Q01105,Q15717 4 Nuclear pore complex npc disassembly 0.3153269770097671 0.1706741355886053 0.8644800012044707 1.0 1.0 28 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Regulation of pten localization 0.4972396025027682 0.170449963297438 0.8646562819469981 1.0 1.0 2 P98170 1 Glucagon like peptide 1 glp1 regulates insulin secretion 0.3871057506929234 0.1660503953234059 0.8681172908971186 1.0 1.0 5 Q9UBI6,P10644,P13861 3 Signalling to ras 0.51558090316257 0.1641422310410728 0.8696191770818154 1.0 1.0 3 Q16539 1 Negative regulators of ddx58 ifih1 signaling 0.3563260789376603 0.1580018598328619 0.8744553331910914 1.0 1.0 8 Q7Z434,Q15366,Q9UII4,Q14258,Q96J02,Q9UHD2,Q13526 7 Flt3 signaling 0.5102803422249844 0.1558956586655731 0.8761152673540877 1.0 1.0 3 P62993 1 Notch4 activation and transmission of signal to the nucleus 0.48619801251381 0.1535111445344592 0.8779952024068753 1.0 1.0 2 Q92542 1 Josephin domain dubs 0.4854619065145449 0.1524392523374453 0.8788404999344495 1.0 1.0 2 P54727 1 Transcriptional regulation by runx3 0.3041886641117368 0.1516748151988134 0.8794434218827232 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Interaction between l1 and ankyrins 0.45561694290977 0.1497085699624201 0.8809945465343516 1.0 1.0 4 Q13813,Q01082,Q12955 3 G1 s dna damage checkpoints 0.3052470864345648 0.1495606516004141 0.8811112543957973 1.0 1.0 37 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Pd 1 signaling 0.4832535885167532 0.1492662387783197 0.8813435543387589 1.0 1.0 2 Q06124 1 Interactions of vpr with host cellular proteins 0.309750439069439 0.1464156211263025 0.8835932963246265 1.0 1.0 32 Q12769,P12235,Q9BTX1,P12236,Q8N1F7 5 Signaling by ntrk3 trkc 0.4988954344624465 0.1392293729143933 0.8892688983176023 1.0 1.0 3 P62993,Q07812 2 Raf activation 0.3521386430678505 0.1364461476681648 0.8914685942150842 1.0 1.0 7 P30153,P35232,P62140,P31946,Q14738,P36507 6 Gastrin creb signalling pathway via pkc and mapk 0.3719764015271725 0.134523549767234 0.892988590314852 1.0 1.0 5 P51812,P62993 2 Rap1 signalling 0.4863770250368204 0.1225376515001217 0.9024732290728998 1.0 1.0 3 P31946,P17612 2 Regulation of tp53 activity through phosphorylation 0.3099828325366763 0.1194410753856385 0.9049259207434756 1.0 1.0 24 Q9UQ84,Q92804 2 Er to golgi anterograde transport 0.2896551309179467 0.11784639015634 0.906189371588896 1.0 1.0 67 Q96PC5,Q9Y6B6,Q14789,Q92734,O75935,Q12955,Q92538,P24390,Q13561,Q9BVK6,Q9Y678,O15027,Q9UJW0,Q9HCU5 14 Receptor mediated mitophagy 0.4797084045145535 0.1143343076085402 0.9089727872699896 1.0 1.0 3 Q96HS1 1 Killing mechanisms 0.4541774015458313 0.1132929196949387 0.9097983303661892 1.0 1.0 2 P63000 1 Degradation of beta catenin by the destruction complex 0.288956755208629 0.1083385205550776 0.9137271674406288 1.0 1.0 45 P30153,P60900,P48729,Q9UL46,P28072,P49720,P28074,P28070,O00231,P20618,P49721 11 Collagen formation 0.3249398303316922 0.1081028375931174 0.9139141172735537 1.0 1.0 11 Q32P28 1 Dex h box helicases activate type i ifn and inflammatory cytokines production 0.4740625825372508 0.1077569869764282 0.9141884635654912 1.0 1.0 3 Q9H2U1 1 Endosomal vacuolar pathway 0.4725296551049067 0.1060287058721336 0.915559576563416 1.0 1.0 3 Q9UIQ6 1 Deactivation of the beta catenin transactivating complex 0.3375138325341164 0.1055050505440977 0.915975062603877 1.0 1.0 8 Q15291,Q04726,P35222,P98170,Q13547,P63104,O14980 7 Transport to the golgi and subsequent modification 0.2882703538576713 0.1049797473868975 0.9163918791522064 1.0 1.0 69 Q96PC5,Q9Y6B6,Q14789,Q92734,O75935,Q12955,Q92538,P24390,Q13561,Q9BVK6,Q9Y678,O15027,Q9UJW0,Q9HCU5 14 Miro gtpase cycle 0.4254143646408881 0.1030789996926054 0.9179002720459122 1.0 1.0 4 P52306,Q8IXI1,O95140 3 Signaling by wnt in cancer 0.3373893805309768 0.1008286989453606 0.919686444465978 1.0 1.0 7 P30153,P48729,P30154,P56545,P35222,Q14738 6 Erk mapk targets 0.3321559257905322 0.1003195650532015 0.9200906251800628 1.0 1.0 9 P30153,Q16539,P51812 3 Mapk targets nuclear events mediated by map kinases 0.3321559257905322 0.1003195650532015 0.9200906251800628 1.0 1.0 9 P30153,Q16539,P51812 3 Signaling by notch4 0.2942666278925495 0.0987789837211481 0.921313755433153 1.0 1.0 40 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Association of tric cct with target proteins during biosynthesis 0.3140807866437353 0.0982474399146107 0.9217358130443783 1.0 1.0 18 Q9Y2T2 1 Protein methylation 0.3313674898636246 0.0976587323468623 0.9222032856738736 1.0 1.0 6 O60678,P13639,P15880,P11142,P55072 5 Cytosolic iron sulfur cluster assembly 0.3302270174790056 0.0953466390254541 0.9240394987801936 1.0 1.0 6 Q9Y5Y2,P18074 2 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3341862799813216 0.0935554873072008 0.9254622704426816 1.0 1.0 7 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Apc cdc20 mediated degradation of nek2a 0.3341862799813216 0.0935554873072008 0.9254622704426816 1.0 1.0 7 Q9UJX2,Q9UJX3,Q9H1A4,P30260 4 Signaling by braf and raf1 fusions 0.3109416026051453 0.0907152395226714 0.9277188611730534 1.0 1.0 19 Q9NRY5,P30086 2 Fc epsilon receptor fceri signaling 0.2871582749353595 0.0893820246898563 0.92877830850684 1.0 1.0 46 P60900,P62993,O43865,Q9UL46,P28074,P28070,O00231,P20618,P49721 9 Triglyceride catabolism 0.3240502562013528 0.0831926961088513 0.9336983202694632 1.0 1.0 6 P43304 1 Triglyceride metabolism 0.3240502562013528 0.0831926961088513 0.9336983202694632 1.0 1.0 6 P43304 1 Transport of connexons to the plasma membrane 0.3417509218188891 0.0814789405567121 0.9350610721868656 1.0 1.0 5 Q13885,P04350 2 Activation of ampk downstream of nmdars 0.3417509218188891 0.0814789405567121 0.9350610721868656 1.0 1.0 5 Q13885,P04350 2 Gap junction assembly 0.3417509218188891 0.0814789405567121 0.9350610721868656 1.0 1.0 5 Q13885,P04350 2 Unfolded protein response upr 0.2994076011478389 0.080645949793002 0.9357235225375886 1.0 1.0 33 O76024,P43307 2 G alpha i signalling events 0.3087892923232839 0.079811032082527 0.9363875499834712 1.0 1.0 19 Q9NZJ7,Q9UBI6,O43865 3 Inositol phosphate metabolism 0.3988950276243148 0.0709713686128307 0.9434205425500264 1.0 1.0 4 Q9BW91,Q01968,Q9NPH2 3 Pcp ce pathway 0.2848625007208301 0.0705289627540875 0.943772648998205 1.0 1.0 46 P60900,P53680,Q9UL46,P28074,P28070,O00231,P20618,P49721 8 Runx1 regulates transcription of genes involved in differentiation of hscs 0.2923659688801606 0.0644057801389314 0.9486471276994192 1.0 1.0 38 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Mapk6 mapk4 signaling 0.2835083565791504 0.0638650868101745 0.9490776521923778 1.0 1.0 45 P60900,Q9UL46,Q9HCE1,P28074,P28070,O00231,P20618,P49721 8 Signaling by mras complex mutants 0.3820390136179691 0.0638187815121822 0.949114523258702 1.0 1.0 2 P31946 1 Maturation of sars cov 2 spike protein 0.318606215415974 0.0625067960604262 0.9501592500513958 1.0 1.0 9 P46977 1 Beta catenin independent wnt signaling 0.2852117386021532 0.0595568413649955 0.952508592917056 1.0 1.0 50 P60900,P53680,Q9UL46,Q9HCE1,P28074,P28070,Q9UBI6,O00231,P20618,P49721 10 G2 m dna replication checkpoint 0.4138438880706942 0.056925798580696 0.954604303335474 1.0 1.0 3 P06493,Q99640 2 Piwi interacting rna pirna biogenesis 0.3163716814159318 0.0561993484039222 0.9551830002425352 1.0 1.0 7 P62487,Q9Y2W6,P19387,P30876,P62875,P24928 6 Signaling by kit in disease 0.4088973484686922 0.0541501471188419 0.9568155392018818 1.0 1.0 3 P62993 1 Interleukin 2 family signaling 0.4088973484686922 0.0541501471188419 0.9568155392018818 1.0 1.0 3 P62993 1 Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.4088973484686922 0.0541501471188419 0.9568155392018818 1.0 1.0 3 P62993 1 Adora2b mediated anti inflammatory cytokines production 0.3164916394154105 0.053947398309433 0.9569770732317132 1.0 1.0 8 P10644,P13861,P17612,P04899,Q9UBI6 5 Oncogenic mapk signaling 0.2996687607928594 0.0533505015154868 0.957452643073356 1.0 1.0 22 P35232,Q9NRY5,P02545,P30086,P51114 5 Maturation of sars cov 2 nucleoprotein 0.37974217311235 0.0526322082717628 0.9580249540374512 1.0 1.0 4 P48729,Q99873,P49840 3 Met receptor recycling 0.3187643200906177 0.0499966316421231 0.9601250725268742 1.0 1.0 5 P46108 1 Notch3 intracellular domain regulates transcription 0.2984909827015181 0.0488003585249314 0.9610783964550156 1.0 1.0 2 P42224 1 Chylomicron assembly 0.2955465587044624 0.0486470258686053 0.9612005930806424 1.0 1.0 2 Q9Y6B6 1 Negative regulation of fgfr1 signaling 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Negative regulation of fgfr3 signaling 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Negative regulation of fgfr2 signaling 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Spry regulation of fgf signaling 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Negative regulation of fgfr4 signaling 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Signaling by fgfr3 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Signaling by fgfr4 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Signaling by fgfr1 0.3168567213060942 0.0477180587094118 0.9619409417279636 1.0 1.0 5 P30153 1 Recycling of eif2 gdp 0.3018798378179181 0.0447128276406708 0.964336208946266 1.0 1.0 6 P05198,Q14232,Q13144,P49770,P20042 5 Met activates ptpn11 0.3804160538520383 0.0414954212456798 0.9669009430286486 1.0 1.0 3 P62993 1 Integrin cell surface interactions 0.371502209131077 0.0385595869399447 0.9692415232630288 1.0 1.0 3 Q08722,P35613 2 Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.3703976435935221 0.0382255666592555 0.9695078365428558 1.0 1.0 3 P49023,Q15404 2 Mapk3 erk1 activation 0.3663475699558194 0.0370541077917842 0.9704418635542392 1.0 1.0 3 P06493,Q06124 2 Glycogen breakdown glycogenolysis 0.2948765204570647 0.034222058502838 0.9727000766999632 1.0 1.0 6 Q96G03,P06737,P11216,P46020,P35573 5 Wnt mediated activation of dvl 0.3523564064801199 0.0336047957167877 0.9731922980007844 1.0 1.0 3 O14641,P67870 2 Ctla4 inhibitory signaling 0.351749539594857 0.0324105299639028 0.974144665203806 1.0 1.0 4 P30153,Q06124,Q14738 3 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.3517495395948547 0.0324105299639011 0.9741446652038072 1.0 1.0 4 P30153,Q14738,P17612 3 Transport of the slbp dependant mature mrna 0.293105414841897 0.0300986864870063 0.9759883482892866 1.0 1.0 29 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Vldlr internalisation and degradation 0.2911905639513499 0.0290167204149901 0.9768512552463362 1.0 1.0 6 P63010,O94973,P53680,Q96CW1,P09496 5 Tnfr2 non canonical nf kb pathway 0.2861430335250681 0.0283675479960842 0.977369006727232 1.0 1.0 39 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Dectin 1 mediated noncanonical nf kb signaling 0.2861430335250682 0.0283675479960839 0.9773690067272324 1.0 1.0 39 P60900,Q9UL46,P28072,P28074,P28070,O00231,P20618,P49721 8 Interleukin 35 signalling 0.3060759192064389 0.0271928792515123 0.9783058951417224 1.0 1.0 3 P42224 1 Interleukin 27 signaling 0.3060759192064389 0.0271928792515123 0.9783058951417224 1.0 1.0 3 P42224 1 Plasma lipoprotein assembly 0.295655375552285 0.0264785945493982 0.9788756066876976 1.0 1.0 3 Q9Y6B6,P17612 2 Translation of sars cov 2 structural proteins 0.2981249456914619 0.0205105135678015 0.9836361252271456 1.0 1.0 14 P48729,P04843,P46977,Q10472,P27824 5 Glutamate neurotransmitter release cycle 0.3263351749539668 0.0198424951350042 0.9841690183319792 1.0 1.0 4 Q13136,O94925,O75915 3 Condensation of prometaphase chromosomes 0.2996309963099686 0.01542792320874 0.9876907865765988 1.0 1.0 9 P19784,P06493,Q9BPX3,Q15003,P67870,P14635,Q9NTJ3,Q15021 8 Viral messenger rna synthesis 0.2903535896904043 0.0154136179345178 0.9877021991769988 1.0 1.0 31 Q12769,Q9BTX1,Q92621,Q8N1F7,Q8NFH5 5 Transcriptional regulation by mecp2 0.29597074906976 0.0141818505342832 0.9886848997077262 1.0 1.0 11 Q9HCE1,Q14739 2 M phase 0.2934824306478378 0.0130685246232479 0.989573122766176 1.0 1.0 166 Q12769,P60900,Q01105,Q8NBT2,Q15005,P41208,Q9BSJ2,Q29RF7,Q92621,Q15691,Q15003,P42167,P43034,Q8N1F7,Q14674,Q9UJX3,O94927,Q86XL3,O75935,Q9Y2U8,Q9H6D7,Q9BTX1,P02545,Q13561,P50402,P04350,Q96CS2,Q92973,Q8NFH5,P30153,Q9UL46,P28074,Q9H1A4,Q14739,P20618,P49721,O95684,Q7Z5K2,P28070,O00231,P28072 41 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.2965695315381683 0.0124283137944584 0.990083895585758 1.0 1.0 8 Q9Y3B8,Q86X55,P06493,Q99873,Q07812,P14635,P12004 7 Met activates rap1 and rac1 0.2780022369786905 0.012140771336637 0.9903133039619784 1.0 1.0 6 P46108 1 The role of gtse1 in g2 m progression after g2 checkpoint 0.2774622014904078 0.0108374536583426 0.9913531323109372 1.0 1.0 46 P60900,Q9UL46,P28072,P04350,Q15691,P28074,P28070,O00231,P20618,P49721 10 Activation of bh3 only proteins 0.2967884828349937 0.010676000132564 0.991481946133746 1.0 1.0 10 Q9Y3B8,Q96FJ2,P63167,P27348,P31946,P63104,Q04917,P62258,P61981 9 Apoptotic cleavage of cell adhesion proteins 0.2744209074028238 0.0091529433003721 0.9926971098231444 1.0 1.0 5 Q9UDY2 1 Zbp1 dai mediated induction of type i ifns 0.2722918201915988 0.0077765860464013 0.9937952445969488 1.0 1.0 5 Q9NZI8,Q08211,Q9UHD2,Q00653 4 Srp dependent cotranslational protein targeting to membrane 0.283909951091512 0.0064121338857203 0.9948838924293272 1.0 1.0 91 P04843,P23396,Q15005,Q15629,Q9Y5M8,P43307,P67812 7 Signalling to erks 0.2952328468996912 0.0055300041878947 0.995587717525944 1.0 1.0 9 Q16539,P46108 2 Rsk activation 0.2635961549626636 0.0051745369491227 0.9958713352837384 1.0 1.0 4 P51812 1 Non integrin membrane ecm interactions 0.2655118516258602 0.0037059754246195 0.9970430661945292 1.0 1.0 5 P11047 1 Ret signaling 0.2449760066714463 0.0035760412053942 0.9971467380147084 1.0 1.0 4 Q06124,P62993 2