Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Mitochondrial calcium ion transport 0.8254915113547419 3.2245075736164788 0.0012618951869971 0.8279882883937809 0.6307654104673127 18 Q9Y277,Q99623,Q9H4I9,P21796,Q10713,Q8WWC4,Q9H300,Q8IYU8,P45880,Q8NE86,Q9BPX6,O95202 12 Cristae formation 0.7756725447830324 2.9141535403754704 0.0035665444489711 0.9931304048587172 0.6307654104673127 21 O75947,Q9Y512,Q9BUR5,Q13505,Q5XKP0,O75964,P56385,P24539,P00846,Q6UXV4 10 Processing of smdt1 0.8037201825911314 2.873011471786902 0.004065793524087 0.9965839466324916 0.6307654104673127 13 Q9UJZ1,Q99623,Q9H4I9,Q10713,Q9H300,Q8WWC4,Q8IYU8,Q8NE86,Q9BPX6 9 Synthesis of pa 0.8218664597224632 2.6368892550726213 0.0083670142464669 0.9999918107364558 0.8777355804124254 10 O15228,Q9NPH0,Q8N2A8,O94830,Q8NF37,Q99943,O15120,Q9NUQ2 8 Formation of atp by chemiosmotic coupling 0.8089607627682075 2.575248067476435 0.0100168216367848 0.9999991961511676 0.8777355804124254 10 O75947,O75964,P56385,P00846 4 Mitochondrial protein import 0.7462954273588785 2.563964571788972 0.0103484106960889 0.9999994960783016 0.8777355804124254 36 Q8N4H5,O43615,P08574,Q9NS69,Q9Y584,P51553,P62072,O14925,P12235,O60830,Q13505,Q9NX63,O96008,Q9Y5J9,P12236,Q99595,Q9Y512,O75746,P21796,Q9Y5J6,Q9Y276,O75431,O94826,Q15388,Q10713 25 Class i peroxisomal membrane protein import 0.7263298205579379 2.4657726107509843 0.0136718095429888 0.999999995366644 0.8777355804124254 13 Q5T8D3,O75381,P56589,Q8TB36,P51648,Q9Y5Y5,P40855,P33897,Q9NR77,O43808 10 Mitophagy 0.75982565441874 2.4286679384630085 0.0151544048817451 0.9999999994308896 0.8777355804124254 11 O94826,Q8N4H5,P21796,Q8IWA4,O96008,Q9NS69 6 Pink1 prkn mediated mitophagy 0.8034871637590342 2.381915642041608 0.017222842322861 0.999999999969637 0.8777355804124254 8 O94826,Q8N4H5,P21796,Q8IWA4,O96008,Q9NS69 6 Glycerophospholipid biosynthesis 0.7036528463281184 2.288897824016947 0.0220852897290166 0.9999999999999698 0.8777355804124254 38 Q9NPH0,Q9BVG9,Q9HBU6,O14735,O95674,Q8NF37,O94830,O15120,Q9NQZ5,P40939,Q96AD5,Q99943,Q8NCC3,Q8N2A8,P43304,Q53H12,Q9UG56,Q92604,O15228,Q8WUK0,Q8IV08,Q6P1A2,Q9C0D9,Q9NUQ2 24 Peroxisomal lipid metabolism 0.6437791978112268 2.1180324110877526 0.0341723228719244 1.0 0.881879213750901 14 Q5T8D3,O15254,O14734,P51648,P33897,O14975,Q15067,O43808 8 Transport of vitamins nucleosides and related molecules 0.7755991285402855 2.1078141714012157 0.0350470665542044 1.0 0.881879213750901 7 Q8TB61,P36404,P05141,O00400,P12236,P12235 6 Sphingolipid de novo biosynthesis 0.6870476386198973 2.0531693791459995 0.040056153075721 1.0 0.881879213750901 11 Q06136,P51648,O95470,Q96G23 4 Slc mediated transmembrane transport 0.6147827885414481 1.957279044550384 0.050314669863585 1.0 0.881879213750901 22 P30825,Q8TB61,Q70HW3,O00400,P12236,Q9UBX3,P12235 7 Defects in cobalamin b12 metabolism 0.852698535619533 1.8849184933735044 0.0594408428999941 1.0 0.881879213750901 4 Q96EY8 1 Transport of inorganic cations anions and amino acids oligopeptides 0.6546113460044867 1.88047310505058 0.0600436284603633 1.0 0.881879213750901 11 Q9UBX3,Q70HW3 2 Activation of ampk downstream of nmdars 0.6963942028075463 1.8721644249665552 0.0611838591544684 1.0 0.881879213750901 8 P54646 1 Synthesis of pg 0.8491915422885549 1.870859034059348 0.0613646224776451 1.0 0.881879213750901 4 Q8WUK0,Q8N2A8,O95674 3 Initiation of nuclear envelope ne reformation 0.5898183470859608 1.847507718832192 0.0646735904632835 1.0 0.9015498510581732 19 Q86XL3,Q14739,P50402,Q8IXJ6,P42167 5 Carboxyterminal post translational modifications of tubulin 0.7156234485931086 1.8295890361883207 0.0673114144077635 1.0 0.907742169356062 7 Q14166 1 Metabolism of porphyrins 0.6633557449219603 1.7735448964147242 0.0761384592896901 1.0 0.924453106440453 9 P30519,P09601 2 Pregnenolone biosynthesis 0.8169940746796444 1.7409983438958752 0.0816838688158103 1.0 0.924453106440453 4 O95772 1 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6676410413245503 1.73016806850475 0.0836002515914466 1.0 0.924453106440453 8 P33897,O14734,Q15067,P33121 4 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.661556993348614 1.7248216477655305 0.0845596192356279 1.0 0.924453106440453 70 O43676,Q9P0S2,O95167,P21912,O14949,Q8N8Q8,O75964,Q9Y6N1,Q9NX14,O75947,Q99643,O75880,P56385,P22695,Q86Y39,P24539,Q9NPL8,O95139,P20674,P03886,P13073,P00846,P09669,Q9UDW1,O14548 25 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.8124999999999976 1.7227654560729162 0.0849309479703803 1.0 0.924453106440453 4 P12236,P12235,P05141 3 Heme degradation 0.8081186137053353 1.7049658634713103 0.0882007911982565 1.0 0.924453106440453 4 P30519 1 Intra golgi traffic 0.5557183337030891 1.6640050800281423 0.0961114142044718 1.0 0.924453106440453 17 O14653,O95249,Q96JB2,O43752,O00461 5 Rab geranylgeranylation 0.5632347926840157 1.6487558807001357 0.0991976568899191 1.0 0.924453106440453 21 P61020,Q13636,P20339,P61019,P61026,Q15907,Q9NP72,Q9H0U4,P62820,Q969Q5 10 Phase i functionalization of compounds 0.5806422265448717 1.642426140371559 0.1005017212584109 1.0 0.924453106440453 13 O43169,Q5VT66,P16435,Q16850,P00387 5 Respiratory electron transport 0.6352835894011735 1.635046119324359 0.1020393799219137 1.0 0.924453106440453 60 O43676,O95167,P21912,Q8N8Q8,O14949,Q9P0S2,Q9Y6N1,Q9NX14,Q99643,O75880,P22695,Q86Y39,Q9NPL8,O95139,P20674,P03886,P13073,P09669,Q9UDW1,O14548 20 Metabolism of fat soluble vitamins 0.7430793157076094 1.6251827800791236 0.104123618467772 1.0 0.924453106440453 5 Q6NUM9,Q8N0U8,Q9Y5Z9,P09455 4 Metabolism of steroid hormones 0.6968607044587352 1.6174991680978226 0.1057705751065374 1.0 0.924453106440453 6 O95772,P30536 2 Metabolism of nitric oxide nos3 activation and regulation 0.740564915259482 1.6142943485899273 0.1064635953582446 1.0 0.924453106440453 5 P35270,P50570 2 Tysnd1 cleaves peroxisomal proteins 0.6938811263013898 1.603801542962179 0.1087578043886163 1.0 0.924453106440453 6 O00116,Q15067,Q2T9J0 3 Synthesis of pe 0.7769341712058964 1.5776427430978046 0.1146477069824072 1.0 0.924453106440453 4 Q9HBU6,Q9UG56 2 Diseases associated with n glycosylation of proteins 0.6371689959906063 1.577461393300734 0.1146893986433823 1.0 0.924453106440453 8 O75340,Q9BV10,Q9BT22 3 Phospholipid metabolism 0.61746235279812 1.5765775507230784 0.1148927616222146 1.0 0.924453106440453 54 Q9NPH0,Q9NTJ5,Q9BVG9,Q9HBU6,O14735,O95674,Q8NF37,O94830,O15120,Q9BZF1,Q9NQZ5,P40939,Q96AD5,Q99943,Q8NCC3,Q8N2A8,P43304,Q53H12,Q96N66,Q9UG56,Q92604,O15228,Q8WUK0,Q8IV08,Q10713,Q6P1A2,Q8N9F7,Q9C0D9,Q9C0I1,Q9NUQ2 30 N glycan trimming in the er and calnexin calreticulin cycle 0.5386493336028918 1.5711891844639898 0.1161387115584535 1.0 0.924453106440453 16 Q9BUN8,P27824,Q13438,O60858 4 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.7298208344280575 1.567673527695281 0.1169573427315697 1.0 0.924453106440453 5 O14734,O14975,O75881 3 Alpha oxidation of phytanate 0.7240110593093196 1.5424026048181014 0.1229757889856024 1.0 0.924453106440453 5 P51648,O43808 2 Tp53 regulates transcription of genes involved in cytochrome c release 0.8797481271229131 1.5415619853133478 0.1231800692946099 1.0 0.924453106440453 3 Q9Y255 1 Tp53 regulates transcription of cell death genes 0.6773422036802017 1.5275052548622037 0.1266354215329301 1.0 0.924453106440453 6 Q9Y255 1 Mitochondrial biogenesis 0.5734265593970966 1.5134539240556433 0.1301643965277521 1.0 0.924453106440453 35 O75947,Q9Y512,Q9BUR5,Q13505,Q5XKP0,O75964,P56385,P24539,P00846,P54646,Q6UXV4 11 Selective autophagy 0.5666466496148574 1.5102166703387447 0.1309881463392079 1.0 0.924453106440453 32 Q8N4H5,P21796,Q13509,O96008,Q9NS69,P54646 6 Degradation of cysteine and homocysteine 0.6470069460109917 1.501501426874063 0.1332259179113113 1.0 0.924453106440453 7 P25325,Q99757,Q9Y6N5,Q9UBX3 4 Translation of sars cov 1 structural proteins 0.6436707292443222 1.4853146844170253 0.1374604837611315 1.0 0.924453106440453 7 Q10472 1 Depolymerisation of the nuclear lamina 0.6073154923992441 1.483758508246346 0.1378729982107189 1.0 0.924453106440453 9 P42167,P50402 2 Pre notch processing in golgi 0.7527227980337863 1.4781225035261991 0.1393749917728075 1.0 0.924453106440453 4 P16615 1 Er quality control compartment erqc 0.7509741605631575 1.4709159790339454 0.1413138407513097 1.0 0.924453106440453 4 Q13438,O60858 2 Sulfur amino acid metabolism 0.566209564521019 1.4707201411982522 0.1413668169490847 1.0 0.924453106440453 12 Q13126,Q9Y6N5,Q99757,P25325,Q9BV57,Q9UBX3 6 Synthesis of very long chain fatty acyl coas 0.6033152473319036 1.4627919153147777 0.1435243259763363 1.0 0.9262634741250596 9 Q53GQ0,P33121,Q9UKU0,Q9P035,Q6Y1H2 5 Abc transporters in lipid homeostasis 0.7424430376599234 1.435726220952017 0.1510802609477521 1.0 0.9345957444489432 4 P33897,P56589 2 O linked glycosylation 0.6964349508596558 1.421935451612126 0.1550449903315973 1.0 0.9345957444489432 5 Q8N4A0,Q10472 2 O linked glycosylation of mucins 0.6964349508596558 1.421935451612126 0.1550449903315973 1.0 0.9345957444489432 5 Q8N4A0,Q10472 2 Cytochrome p450 arranged by substrate type 0.7341726195453022 1.401567484109285 0.1610444424705748 1.0 0.9345957444489432 4 Q16850,P16435 2 Miro gtpase cycle 0.6495507450270674 1.3983915253784631 0.1619955266469404 1.0 0.9345957444489432 6 Q8IWA4,Q8IXI1 2 Synthesis secretion and deacylation of ghrelin 0.8380433674792205 1.3843658155570242 0.166246470654761 1.0 0.9345957444489432 3 P67812 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8380433674792205 1.3843658155570242 0.166246470654761 1.0 0.9345957444489432 3 P67812 1 Beta oxidation of pristanoyl coa 0.7296511378532741 1.3828767530055843 0.1667026594933509 1.0 0.9345957444489432 4 O15254,O14734 2 Ire1alpha activates chaperones 0.5324998691510976 1.360267354164597 0.1737453351611158 1.0 0.9345957444489432 27 O14653,P43307,O76024,Q9NWM8,Q9Y5M8,O43731,O95070 7 Protein localization 0.6171999398026992 1.3532190210913415 0.1759856703541942 1.0 0.9363512384494148 81 Q8N4H5,O43681,O43615,P08574,Q9NS69,Q9Y584,P51553,P62072,Q15067,P09601,O14925,Q3ZCQ8,P12235,Q5T8D3,O60830,Q13505,Q9NX63,P51648,Q9Y5Y5,O96008,P33897,Q9Y5J9,Q9NR77,P12236,O43808,P46379,Q99595,O15254,Q9Y512,O75746,P21796,Q2T9J0,P56589,Q8TB36,P40855,O14975,P50402,Q9Y5J6,Q9Y276,O75431,O94826,O15228,Q15388,Q10713,O75381 45 Signaling by pdgfr in disease 0.6744625482316926 1.3254529778234505 0.1850209556001671 1.0 0.9587151269742488 5 Q6UN15,O43815,P40763 3 Beta oxidation of very long chain fatty acids 0.6292265907584924 1.3033826030868398 0.1924441728257164 1.0 0.9790772880257254 6 P33897,Q15067 2 Gamma carboxylation hypusine formation and arylsulfatase activation 0.5613727788217763 1.3001258676208074 0.1935578331866319 1.0 0.9793602679981716 10 O60725,Q9BU89,P38435,O43681 4 Ras processing 0.6254994526477398 1.2859176598679096 0.1984717997343708 1.0 0.9793602679981716 6 P49356,O60725,P36404 3 Tp53 regulates metabolic genes 0.5481092239901519 1.2838162608151449 0.1992062526075 1.0 0.9793602679981716 40 P15954,Q9P0S2,Q8N8Q8,Q7LG56,O75880,P13073,P31751,Q9Y6N1,P06744,P09669,O14548,P54646,P20674 13 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7054724078273917 1.2827939560956192 0.1995642721457964 1.0 0.9793602679981716 4 P67812 1 Incretin synthesis secretion and inactivation 0.7054724078273917 1.2827939560956192 0.1995642721457964 1.0 0.9793602679981716 4 P67812 1 Aflatoxin activation and detoxification 0.7012731267920245 1.265398708689734 0.205728437884342 1.0 0.9793602679981716 4 O14880 1 Signaling by pdgf 0.6209450962574737 1.2645621694895346 0.2060283214517575 1.0 0.9793602679981716 6 P46108,P46109,P62993,P40763 4 Downstream signal transduction 0.6209450962574737 1.2645621694895346 0.2060283214517575 1.0 0.9793602679981716 6 P46108,P46109,P62993,P40763 4 Apoptotic factor mediated response 0.6577869527131409 1.2520374749625198 0.2105562089566597 1.0 0.9854347169404106 5 Q07812,Q9NR28,Q07021 3 Bile acid and bile salt metabolism 0.594205192113971 1.2433619085149834 0.2137345003452915 1.0 0.9916200483254316 7 O14734,O14975,O75881 3 Synthesis of bile acids and bile salts 0.594205192113971 1.2433619085149834 0.2137345003452915 1.0 0.9916200483254316 7 O14734,O14975,O75881 3 Piwi interacting rna pirna biogenesis 0.5391788368138297 1.2418140812070615 0.2143051661336334 1.0 0.9916200483254316 11 Q8N2A8 1 Gaba receptor activation 0.6922067272656892 1.2278407673838343 0.2195067485389652 1.0 1.0 4 P63096 1 Interleukin 12 family signaling 0.5080371444227427 1.1857281814226368 0.2357296615641892 1.0 1.0 28 Q13126,O14979,P51809,P40763,Q9UL46,P27824,P14174,Q53EL6,P52597,P09661,Q99439,P22626 12 Post translational modification synthesis of gpi anchored proteins 0.5600392591915542 1.1824791640726229 0.2370156281817004 1.0 1.0 8 O43292,Q9H490,Q9Y2B2 3 Enos activation 0.7829697131627671 1.1767160367984095 0.2393088648146686 1.0 1.0 3 P35270 1 Interleukin 27 signaling 0.7789999640355945 1.1617979110633545 0.2453175627915746 1.0 1.0 3 P27824 1 Interleukin 35 signalling 0.7789999640355945 1.1617979110633545 0.2453175627915746 1.0 1.0 3 P27824 1 Cargo concentration in the er 0.4726684649684132 1.1583993734227285 0.2467010947467482 1.0 1.0 15 O14653,Q96PC5,Q9HCU5,Q13190,O75396,Q5JRA6,Q12907,P49755 8 Metabolism of cofactors 0.5759437541773607 1.15337153873071 0.2487579182834367 1.0 1.0 7 Q5HYK3,P35270,O75208 3 Heme biosynthesis 0.6351066448661402 1.1520839862974717 0.2492865628871139 1.0 1.0 5 Q7KZN9,P22830 2 Calnexin calreticulin cycle 0.5443309986145421 1.1503476108327677 0.2500007285341872 1.0 1.0 9 P27824,Q13438,O60858 3 Synthesis of pc 0.6306499191159407 1.13244779316698 0.2574462213557311 1.0 1.0 5 Q9NQZ5 1 Complex i biogenesis 0.5081405003738921 1.1288404129053475 0.2589651611292005 1.0 1.0 32 O43676,Q8N183,P03886,O95167,Q86Y39,Q9NPL8,O95139,Q9NX14 8 Oncogene induced senescence 0.5880513593325247 1.110039008408959 0.2669822174892347 1.0 1.0 6 Q9HCE1,P11802 2 Linoleic acid la metabolism 0.7641372897301872 1.1060605740701157 0.268700301954681 1.0 1.0 3 P33897 1 Cholesterol biosynthesis 0.4746524809982777 1.105435928613493 0.2689707427688295 1.0 1.0 19 Q9H2C2,Q14739,Q14534,Q15800,Q16850,P14324 6 Pyruvate metabolism 0.4661415671744127 1.0986854650084628 0.271905284640638 1.0 1.0 16 P21796 1 Attachment of gpi anchor to upar 0.6191231092912775 1.081697152800789 0.2793871187190651 1.0 1.0 5 Q92643,O43292,Q9H490 3 Unwinding of dna 0.5109446019878082 1.081521078668169 0.2794653895201282 1.0 1.0 11 Q9Y248 1 Interleukin 4 and interleukin 13 signaling 0.4907370065007207 1.0295046726522612 0.3032425851839966 1.0 1.0 12 P09601,Q07820,P40763 3 Ra biosynthesis pathway 0.742617345352787 1.025785020723456 0.3049929282572652 1.0 1.0 3 Q9HBH5,Q8NBN7 2 Interleukin 12 signaling 0.4751833537130738 1.0148191602903822 0.3101920386080428 1.0 1.0 25 Q13126,O14979,P09661,P51809,Q9UL46,P14174,Q53EL6,P52597,P07237,Q99439,P22626 11 Wnt ligand biogenesis and trafficking 0.5662821524221211 1.007804430408611 0.3135483585799561 1.0 1.0 6 Q9Y3A6 1 Regulation of beta cell development 0.7301944943725596 0.9797486391938446 0.3272102104024648 1.0 1.0 3 Q13573 1 Wax and plasmalogen biosynthesis 0.6291303289181822 0.9677097809663324 0.3331893319018253 1.0 1.0 4 O15228,O00116 2 Growth hormone receptor signaling 0.5561387789334065 0.960284782482563 0.336911906725744 1.0 1.0 6 P18031,P40763 2 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4609284211494881 0.951841034568059 0.3411776077118023 1.0 1.0 23 O14979,Q9UL46,P14174,P52597,P09661,Q99439 6 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.722563990664822 0.9516074082308092 0.3412961230205549 1.0 1.0 3 P35270 1 Reduction of cytosolic ca levels 0.715536174248212 0.9257923189554996 0.3545539196824379 1.0 1.0 3 P16615 1 Platelet calcium homeostasis 0.715536174248212 0.9257923189554996 0.3545539196824379 1.0 1.0 3 P16615 1 Acyl chain remodelling of pg 0.8772529521441894 0.9225026610317149 0.3562664429445061 1.0 1.0 2 Q92604 1 Akt phosphorylates targets in the cytosol 0.582440486244042 0.9209863206308432 0.3570575689543731 1.0 1.0 5 P31751,Q96B36 2 The citric acid tca cycle and respiratory electron transport 0.5691486278000506 0.9054046053463022 0.365251076845702 1.0 1.0 103 O43676,O95563,Q9P0S2,Q8N8Q8,P21912,O14949,O95167,O75964,Q9H9P8,Q9Y6N1,Q9NX14,O75947,Q99643,O75880,P56385,P21796,P22695,Q86Y39,Q9NPL8,P24539,O95139,P20674,P03886,P13073,P00846,P09669,Q9UDW1,O14548 28 Activation of bad and translocation to mitochondria 0.5205888715159955 0.8805706447749488 0.3785502529553115 1.0 1.0 7 P27348,P31751,P63104,P62258,P31946 5 Signaling by erbb2 in cancer 0.7030828407078632 0.8803217296117062 0.3786850443058189 1.0 1.0 3 Q16543 1 Signaling by erbb2 ecd mutants 0.7030828407078632 0.8803217296117062 0.3786850443058189 1.0 1.0 3 Q16543 1 Constitutive signaling by overexpressed erbb2 0.7030828407078632 0.8803217296117062 0.3786850443058189 1.0 1.0 3 Q16543 1 Signaling by kit in disease 0.5995211595187397 0.8475247107485644 0.3967027195999528 1.0 1.0 4 P40763 1 Erythropoietin activates ras 0.6865003496223389 0.8204038957258044 0.4119858953686459 1.0 1.0 3 P46109 1 Signaling by erythropoietin 0.6865003496223389 0.8204038957258044 0.4119858953686459 1.0 1.0 3 P46109 1 Negative regulators of ddx58 ifih1 signaling 0.5060577135340442 0.8095239376322212 0.418213839528351 1.0 1.0 7 Q86UT6,P61086,Q7Z434 3 Endogenous sterols 0.6828162738475783 0.8072026096346683 0.4195497624941449 1.0 1.0 3 Q16850 1 Iron uptake and transport 0.4231311571824775 0.7832801305764203 0.4334626285405552 1.0 1.0 18 P63208,Q93050,P09601,P30519 4 Signal regulatory protein family interactions 0.6714330121230659 0.7666967610808121 0.4432618298254378 1.0 1.0 3 P62993,Q08722 2 Josephin domain dubs 0.6703738914893096 0.7629511062843609 0.4454925556785101 1.0 1.0 3 P54725 1 Synthesis of dolichyl phosphate 0.668427687840512 0.7560789748106005 0.44960184698701 1.0 1.0 3 Q86YN1 1 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4227274235219125 0.7488504585411069 0.453947343065662 1.0 1.0 20 Q86YN1,Q86SQ9,O75340,Q9BT22 4 Pyrimidine salvage 0.665151644299685 0.744543241956278 0.4565478908360838 1.0 1.0 3 Q9BZX2 1 Peptide hormone metabolism 0.4396156287965151 0.730103743034893 0.465326773572948 1.0 1.0 12 P67812 1 Small interfering rna sirna biogenesis 0.6600172582137798 0.7265477244256671 0.4675030617696953 1.0 1.0 3 Q99598 1 Glycosaminoglycan metabolism 0.4181624159103184 0.7255446885757446 0.4681179396076256 1.0 1.0 14 Q9NRB3,Q8NCH0,Q8TB61,Q7LGA3 4 Ubiquinol biosynthesis 0.659155856985997 0.7235389355956859 0.4693488421694634 1.0 1.0 3 O75208 1 Acyl chain remodelling of pc 0.5643173902661 0.7079208856204302 0.4789943889268935 1.0 1.0 4 Q6P1A2,Q8NF37 2 Assembly of the hiv virion 0.8138595400870128 0.706694530985085 0.4797563289598674 1.0 1.0 2 Q99816 1 Visual phototransduction 0.467885934641492 0.7061575568449755 0.4800901615702075 1.0 1.0 8 P49356,Q6NUM9,P53582,P09455 4 Pi5p regulates tp53 acetylation 0.6531398886011635 0.7026117945132574 0.4822977101916561 1.0 1.0 3 Q13526 1 Prolactin receptor signaling 0.6505103603745869 0.6935134239594781 0.4879874044480066 1.0 1.0 3 P63208 1 Golgi cisternae pericentriolar stack reorganization 0.4320464832931779 0.6863659266648479 0.4924823853577709 1.0 1.0 12 Q08379,O95067,P61019,Q9H8Y8,Q9H0U4,P62820,P06493 7 Regulation of runx1 expression and activity 0.6480907295876803 0.6851683946842445 0.4932376652142809 1.0 1.0 3 Q9HCE1 1 Class a 1 rhodopsin like receptors 0.4793794228359112 0.6806153633583536 0.4961149030922396 1.0 1.0 7 P07602,Q9NRV9,Q9BYT8,Q9NZJ7 4 Peptide ligand binding receptors 0.4793794228359112 0.6806153633583536 0.4961149030922396 1.0 1.0 7 P07602,Q9NRV9,Q9BYT8,Q9NZJ7 4 Circadian clock 0.4537847350992179 0.6692931680857006 0.5033084840273703 1.0 1.0 9 P50416,Q9BWF3,P63208 3 Release of apoptotic factors from the mitochondria 0.8023617153511453 0.6692672796770245 0.5033249951782801 1.0 1.0 2 Q07812 1 Trna modification in the mitochondrion 0.4924461162262971 0.6668272047945399 0.5048825134132189 1.0 1.0 6 Q969Y2,O15091,Q9Y606 3 Miscellaneous transport and binding events 0.5207002743356064 0.6574540558631412 0.5108890036426681 1.0 1.0 5 Q8N4V1 1 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.4346935654142773 0.6508838264736995 0.515121482599378 1.0 1.0 11 O43681,P51648,P50402,P09601,P46379 5 Ncam signaling for neurite out growth 0.517884914463458 0.6457924139011304 0.5184138015788047 1.0 1.0 5 P27361,Q01082,P62993,Q13813 4 Acyl chain remodelling of ps 0.7917961466749297 0.635448061938878 0.5251362305318505 1.0 1.0 2 Q6P1A2 1 Intrinsic pathway for apoptosis 0.3914014295639411 0.6103997391833987 0.5415970408832698 1.0 1.0 16 Q07812,Q07021,P40763,P31751,P62258,P63104,Q9NR28,P27361 8 Acyl chain remodelling of pe 0.7827843380981727 0.6070688626050293 0.5438052131350037 1.0 1.0 2 Q6P1A2 1 Regulation of localization of foxo transcription factors 0.5070509365716629 0.6013158888097349 0.5476296088095527 1.0 1.0 5 P31946,P31751,P63104 3 Signaling by cytosolic fgfr1 fusion mutants 0.4620982971473105 0.5986745401602224 0.549389938246136 1.0 1.0 7 O95684,P40763 2 Interleukin 2 family signaling 0.6206696203183042 0.5925960748613338 0.5534515065892962 1.0 1.0 3 P40763 1 Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.620669620318304 0.5925960748613338 0.5534515065892962 1.0 1.0 3 P40763 1 Gpcr ligand binding 0.4366067891715898 0.5804897102808647 0.5615844237353984 1.0 1.0 9 P07602,Q9NRV9,Q9BYT8,Q9NZJ7,Q9Y3E5 5 G alpha s signalling events 0.5287594810053895 0.5725057466465394 0.5669793937613663 1.0 1.0 4 P63096 1 Aspartate and asparagine metabolism 0.4957196581204421 0.55554796066463 0.5785199147882651 1.0 1.0 5 O75746,P08243 2 Suppression of apoptosis 0.5177238805970079 0.53201125586536 0.5947181997205764 1.0 1.0 4 P27361,P23246,P49840 3 Runx2 regulates bone development 0.5177238805970079 0.53201125586536 0.5947181997205764 1.0 1.0 4 P46937,Q96PK6,P27361 3 Sphingolipid metabolism 0.4021966866506092 0.5273065642379557 0.5979807165554618 1.0 1.0 26 O95470,O43681,P51648,Q9NZJ7,Q96G23 5 Dna damage recognition in gg ner 0.3831680006469503 0.5270244594725151 0.5981766030568823 1.0 1.0 18 Q99627,P41208,Q9BT78 3 Cytoprotection by hmox1 0.476422912049464 0.5226980195626665 0.6011844166506841 1.0 1.0 66 P20674,P49721,O14548,Q9P0S2,Q8N8Q8,Q9UL46,P40763,O75880,P61289,P60900,Q9Y6N1,P13073,P09669,P30519,P09601,P63208 16 Chylomicron assembly 0.7535736482287183 0.518370822741624 0.6041995678673044 1.0 1.0 2 Q9Y6B6 1 Interleukin 23 signaling 0.7535736482287181 0.518370822741624 0.6041995678673044 1.0 1.0 2 P40763 1 Chondroitin sulfate dermatan sulfate metabolism 0.4835785309470166 0.5074783484253511 0.6118192245218343 1.0 1.0 5 Q8NCH0 1 Formation of apoptosome 0.5910012064378092 0.4973282840941769 0.6189575693709288 1.0 1.0 3 Q9NR28 1 Cytochrome c mediated apoptotic response 0.5910012064378092 0.4973282840941769 0.6189575693709288 1.0 1.0 3 Q9NR28 1 Rac2 gtpase cycle 0.4168565625875485 0.4952480268368829 0.6204250529930802 1.0 1.0 35 Q13153,Q86XL3,Q9Y512,Q14739,Q13505,O15173,Q68EM7,Q9Y6W5,Q9UH62,P50402,P42167 11 Other interleukin signaling 0.745494095711607 0.4948135492938495 0.620731739219027 1.0 1.0 2 Q12846 1 Unfolded protein response upr 0.4309917967696461 0.4823271667773317 0.6295735514240768 1.0 1.0 43 O14653,P43307,O76024,Q9NWM8,Q9Y5M8,O43731,O95070,P08243 8 Intraflagellar transport 0.3866789360615161 0.4777833727006644 0.6328043967606594 1.0 1.0 13 Q9Y496,Q92973,Q13509 3 Response to elevated platelet cytosolic ca2 0.4097275128630468 0.4774052614887313 0.6330735682923634 1.0 1.0 33 Q8NBM8,P07602,Q9NUQ9,Q96JJ7,Q9Y6I9,Q9NZJ7,Q92520,Q8NBX0,Q12846,O94919,P37802,Q6UXV4 12 Notch4 activation and transmission of signal to the nucleus 0.7361715351149837 0.4682063864485868 0.6396370055273133 1.0 1.0 2 P63104 1 Prolonged erk activation events 0.4330903650271137 0.4652425944562097 0.64175773901382 1.0 1.0 7 P46108,P46109,P27361 3 Synthesis of pi 0.7293349906774134 0.4491027987133165 0.6533575016118565 1.0 1.0 2 O14735 1 Signaling by retinoic acid 0.3841130004271823 0.4180360747091111 0.6759207418415447 1.0 1.0 12 Q9HBH5,P50416,Q15120,Q8NBN7 4 Interleukin 15 signaling 0.717526413921693 0.4169588554426716 0.6767085028752948 1.0 1.0 2 P40763 1 Signaling by ntrk3 trkc 0.7175264139216668 0.4169588554426012 0.6767085028753463 1.0 1.0 2 Q07812 1 Interleukin 20 family signaling 0.5629279349954042 0.4129632569191934 0.6796335340649682 1.0 1.0 3 P40763 1 Cell surface interactions at the vascular wall 0.3659777073973626 0.4097686113011151 0.6819756938581583 1.0 1.0 14 P14174,Q08722,P35613 3 Diseases of glycosylation 0.3736057921899764 0.4087759392271719 0.6827040987671937 1.0 1.0 22 Q8NCH0,Q9BT22,Q9BV10,Q86SQ9,O43505,O75340 6 Rhod gtpase cycle 0.3838434941634864 0.4003798768216241 0.6888767434617038 1.0 1.0 27 Q14739,O15173,Q68EM7,P50402,P42167 5 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.3994233603540862 0.3952564975004194 0.6926536009694835 1.0 1.0 9 P27348,O96017,P63104,P62258,P31946,P06493 6 Nr1h2 and nr1h3 mediated signaling 0.4507669975244648 0.3836807426296462 0.7012150873825553 1.0 1.0 5 Q8NB78,O00767 2 G2 m dna replication checkpoint 0.4733427768463575 0.3789032372604011 0.7047597201566134 1.0 1.0 4 Q99640,O95067 2 Integrin cell surface interactions 0.472598253617259 0.3764898538367846 0.7065527570525667 1.0 1.0 4 Q08722 1 Signal attenuation 0.5466142480539412 0.3669651895672587 0.7136449839959631 1.0 1.0 3 P62993 1 Activation of bh3 only proteins 0.3932866042587298 0.3659349362651979 0.7144136263331173 1.0 1.0 9 P27348,P31751,P63104,P62258,P31946 5 Post translational protein modification 0.2691603186468594 0.3656913095286436 0.7145954316288123 1.0 1.0 396 O76024,O43681,A8CG34,O43292,Q9BW61,P38435,Q9BV10,Q9UL46,P61289,Q86YN1,P61026,Q15907,Q07065,Q14166,Q9BTX1,Q9UBV2,Q9BUN8,Q9BU89,P24390,Q9H490,Q9BT22,P46977,Q99627,Q7Z434,Q8N4A0,P45880,O43505,Q9H0U4,P62820,Q969Q5,P54725,Q92643,Q9Y277,Q8NFH5,P21796,O60725,O95249,O75396,P41208,O60858,Q02818,P60900,O75935,P56962,O43731,O75340,Q96PC5,O14653,Q12893,Q9Y2B2,P49721,Q9HCU5,Q13509,P61962,Q92564,Q13438,Q10472,Q86SQ9,P27824,P49366,Q9BT78,O75381,Q9NP72,Q96JB2 64 Arms mediated activation 0.6939092604101997 0.3561329571468834 0.7217409968799227 1.0 1.0 2 P46108 1 Stimuli sensing channels 0.378810688345278 0.353324280826802 0.7238453444483457 1.0 1.0 11 Q9C0H2,Q4KMQ2,Q9NW15 3 Nucleotide salvage 0.3952009284523327 0.3518164213922953 0.7249759424414712 1.0 1.0 8 Q08623,P55263,Q9BZX2 3 Synthesis of leukotrienes lt and eoxins ex 0.5346438469910764 0.3347864968691203 0.7377861472535892 1.0 1.0 3 P09960 1 Regulation of ifng signaling 0.5246592156215134 0.3090310018412127 0.757297944202127 1.0 1.0 3 P18031 1 Regulation of ifna signaling 0.5246592156215134 0.3090310018412127 0.757297944202127 1.0 1.0 3 P18031 1 Ddx58 ifih1 mediated induction of interferon alpha beta 0.3557684732766879 0.3073804257478897 0.7585538254780724 1.0 1.0 13 O94826,Q86UT6,P61086,Q7Z434,P09429 5 Stat5 activation 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Activated ntrk2 signals through frs2 and frs3 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr2 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr1 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Tie2 signaling 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Signaling by flt3 itd and tkd mutants 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr4 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr1 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr4 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Frs mediated fgfr4 signaling 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Pi 3k cascade fgfr3 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr3 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Frs mediated fgfr3 signaling 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Frs mediated fgfr2 signaling 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Downstream signaling of activated fgfr2 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Stat5 activation downstream of flt3 itd mutants 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Frs mediated fgfr1 signaling 0.6712243629583674 0.3024109036956721 0.7623388436948033 1.0 1.0 2 P62993 1 Signaling by leptin 0.6712243629583472 0.302410903695626 0.7623388436948384 1.0 1.0 2 P40763 1 Response of eif2ak1 hri to heme deficiency 0.5212959738012579 0.3005862999190808 0.7637299796850645 1.0 1.0 3 P08243 1 Interaction between l1 and ankyrins 0.5200497357786849 0.2974872919733495 0.766094508626675 1.0 1.0 3 Q12955,Q13813 2 Runx2 regulates osteoblast differentiation 0.5175629468448957 0.2913526038154632 0.7707816595047812 1.0 1.0 3 P46937,P27361 2 Mapk1 erk2 activation 0.5175629468448957 0.2913526038154632 0.7707816595047812 1.0 1.0 3 P36507,Q06124 2 Regulation of gene expression in beta cells 0.6628340584213623 0.2837836535546335 0.7765761823263244 1.0 1.0 2 P31751 1 Rhot1 gtpase cycle 0.5138327634442119 0.2822746387349261 0.7777329305485212 1.0 1.0 3 Q96H55,P52306 2 Proton coupled monocarboxylate transport 0.6609695463020417 0.2797383038058087 0.7796782888556888 1.0 1.0 2 P35613 1 Synthesis of pips at the er membrane 0.512454011638007 0.2789572853257363 0.7802776053563938 1.0 1.0 3 Q9NTJ5 1 Adora2b mediated anti inflammatory cytokines production 0.3888455223816429 0.2767124069937363 0.7820009443379417 1.0 1.0 7 P63096,P10644 2 Cardiac conduction 0.3689401474414452 0.2766794738639887 0.782026234297458 1.0 1.0 10 P54709,P05023,P16615 3 Ion homeostasis 0.3689401474414452 0.2766794738639887 0.782026234297458 1.0 1.0 10 P54709,P05023,P16615 3 Methionine salvage pathway 0.5111696363296498 0.2758856276728797 0.7826359131380476 1.0 1.0 3 Q9BV57 1 Glutamate and glutamine metabolism 0.3881107998755031 0.2737826258543455 0.7842516762170706 1.0 1.0 7 P54886,Q96C36,O94925,P32322,P00505,P04181 6 Peroxisomal protein import 0.3551657806888023 0.2731684645135793 0.7847237200556005 1.0 1.0 24 O15254,O15228,Q2T9J0,O14734,O00116,P50542,Q92968,O14975,O75381,Q15067 10 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.5077552165655157 0.2678078182049543 0.78884725242844 1.0 1.0 3 Q8NB78 1 Arachidonic acid metabolism 0.3707352271795795 0.2622383125313144 0.7931377174987988 1.0 1.0 9 Q15165 1 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3594997846979361 0.2587362310524156 0.7958387628403161 1.0 1.0 11 O60566,Q96DE5,Q13257,Q9UJX5 4 Apc cdc20 mediated degradation of nek2a 0.3594997846979361 0.2587362310524156 0.7958387628403161 1.0 1.0 11 O60566,Q96DE5,Q13257,Q9UJX5 4 Regulation of tp53 activity through methylation 0.4992228784582005 0.2481894058192576 0.8039878628998163 1.0 1.0 3 O96017,P04637 2 Trna processing in the mitochondrion 0.4225746268656628 0.2289290983330428 0.8189240238672364 1.0 1.0 4 Q99714,Q9BQ52,O15091 3 Downregulation of erbb2 signaling 0.3813176755619774 0.2164490940476293 0.8286377016126465 1.0 1.0 6 P31751,Q16543 2 Raf independent mapk1 3 activation 0.3731714908185438 0.2159333727813089 0.8290396829849813 1.0 1.0 7 Q06124,Q99956,P36507,P28482,P27361,P06493 6 Cyclin d associated events in g1 0.3554544247953937 0.2155462376409385 0.8293414667169778 1.0 1.0 10 P63208 1 Cellular response to chemical stress 0.4422843841865792 0.2132286928736839 0.8311485891723494 1.0 1.0 77 P20674,P49721,O14548,Q9P0S2,Q99757,Q8N8Q8,P40763,P13073,O75880,P61289,Q9UL46,Q8TED1,Q9Y6N1,P60900,P09669,P30519,P09601,P63208 18 Rnd2 gtpase cycle 0.326306970026565 0.2072565286609177 0.8358095220929425 1.0 1.0 17 P51648 1 Pi metabolism 0.3262039565215945 0.2067034862339407 0.8362414345808662 1.0 1.0 17 Q9NTJ5,P20338,Q10713,P42356,Q9C0I1,Q8N9F7,P20339 7 Notch3 activation and transmission of signal to the nucleus 0.4790177183711587 0.2050671797080561 0.8375196382886254 1.0 1.0 3 Q9Y6A5,Q92542 2 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3272038306637529 0.1988051571597623 0.8424151616889217 1.0 1.0 18 P50990,Q9UHV9,Q99471,P04350,Q13509,P61758,Q99832 7 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.3940114224857715 0.1980239785227695 0.8430263030574483 1.0 1.0 5 P31751,O14654,P62993 3 Constitutive signaling by akt1 e17k in cancer 0.3748096451858764 0.1946543503523339 0.8456635513544761 1.0 1.0 6 P31751,Q96B36 2 Basigin interactions 0.3722523662332077 0.186278864031418 0.8522260814277018 1.0 1.0 6 P05026,P54709,P35613 3 Regulation of lipid metabolism by pparalpha 0.3292126349514154 0.1834529093006297 0.8544426645880234 1.0 1.0 20 O75192,Q13503,P23786,P50416,Q15067 5 Translation of sars cov 2 structural proteins 0.3232486261381884 0.1778883615488957 0.858810651206634 1.0 1.0 18 P27824,Q10472 2 Antigen presentation folding assembly and peptide loading of class i mhc 0.3180827440708167 0.1769031655350806 0.8595844521024083 1.0 1.0 16 Q03518,Q9NZ08 2 Biological oxidations 0.3811040135337833 0.1766244286513869 0.8598034044667842 1.0 1.0 44 O43169,Q5VT66,Q8TB61,Q99735,P16435,P21964,P28161,Q16850,P00387,O14880 10 Trna modification in the nucleus and cytosol 0.3219555202538894 0.1713291159200709 0.8639649877328104 1.0 1.0 14 Q96FX7,Q5VV42,Q08J23 3 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.3209353000981126 0.1658356812903056 0.868286265286901 1.0 1.0 18 Q07065,Q02818 2 Antigen activates b cell receptor bcr leading to generation of second messengers 0.4581908610506773 0.1657104579782331 0.8683848155724805 1.0 1.0 3 P07948,P62993 2 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.456947466583781 0.1635277840171524 0.8701028990967634 1.0 1.0 3 P04637,P24941 2 Prevention of phagosomal lysosomal fusion 0.4568891196146996 0.1634258259193503 0.8701831700828806 1.0 1.0 3 P20339 1 Regulation of pyruvate dehydrogenase pdh complex 0.3472438492681433 0.1624962861142843 0.870915052661839 1.0 1.0 9 P08559,O43708,Q15120,P09622,Q15118,P11177,P10515,O00330 8 Pecam1 interactions 0.5922933499067772 0.1557061448461391 0.8762646533649774 1.0 1.0 2 Q06124 1 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3486800681329616 0.1546101684249079 0.8771286531547866 1.0 1.0 8 Q96DE5 1 Sars cov 1 infection 0.3231465908022312 0.1450246935843252 0.8846913752343799 1.0 1.0 13 Q10472 1 Insulin receptor signalling cascade 0.3551296545810156 0.1330875382965784 0.8941241504719619 1.0 1.0 6 P31751,P62993,P27361 3 Crmps in sema3a signaling 0.3762437810945203 0.1223881356837993 0.9025916342264748 1.0 1.0 4 P49841,Q16555,Q9BPU6 3 Abc transporter disorders 0.3662554526492002 0.1192973167829994 0.905039809216912 1.0 1.0 42 Q9BUN8,P49721,Q13438,Q9UL46,P33897,P61289,Q9UBV2 7 Mapk3 erk1 activation 0.3739723596339009 0.1179938928334731 0.9060724968922288 1.0 1.0 4 P27361,P06493 2 Negative feedback regulation of mapk pathway 0.3728233830845732 0.1158013896725445 0.9078099491273413 1.0 1.0 4 P36507,P28482,P27361 3 Ticam1 rip1 mediated ikk complex recruitment 0.5612181479179696 0.1157973136141263 0.9078131796190256 1.0 1.0 2 Q13546 1 Ikk complex recruitment mediated by rip1 0.5612181479179696 0.1157973136141263 0.9078131796190256 1.0 1.0 2 Q13546 1 Dap12 interactions 0.423780784372779 0.1122921531701452 0.9105917633168416 1.0 1.0 3 P10321 1 Regulation of signaling by cbl 0.3595469287502393 0.1083497362890071 0.9137182709487344 1.0 1.0 5 P46109,P62993 2 Receptor mediated mitophagy 0.4159154491762546 0.1020970748952283 0.9186796227787436 1.0 1.0 3 Q96HS1,P67870 2 G alpha i signalling events 0.3118034631762955 0.09556042832931 0.9238696949339004 1.0 1.0 20 P63096,Q9NZJ7 2 Gpvi mediated activation cascade 0.3524105754276733 0.092285643869678 0.9264710942250736 1.0 1.0 5 P07948,Q06124,P60953,P61586 4 Egr2 and sox10 mediated initiation of schwann cell myelination 0.3355927506003086 0.0871731443657045 0.9305338857672854 1.0 1.0 7 Q16850 1 Fgfr1 mutant receptor activation 0.3262583951635939 0.0822472048102712 0.9344501365605472 1.0 1.0 9 P62993,Q16630,O95684,P40763 4 Signaling by fgfr1 in disease 0.3262583951635939 0.0822472048102712 0.9344501365605472 1.0 1.0 9 P62993,Q16630,O95684,P40763 4 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.352300995024868 0.0800711906515312 0.93618063568721 1.0 1.0 4 Q96JJ3,P46108,P61586 3 G protein mediated events 0.3255666415469735 0.0797621742462553 0.9364264090132616 1.0 1.0 9 P63096 1 Caspase activation via extrinsic apoptotic signalling pathway 0.3944668946223259 0.0779587789347577 0.937860842799894 1.0 1.0 3 Q9UKG1,Q13546 2 Signaling by nodal 0.5174021131137496 0.0754796955387899 0.9398330520586976 1.0 1.0 2 P27361 1 Signaling by activin 0.5174021131137496 0.0754796955387899 0.9398330520586976 1.0 1.0 2 P27361 1 Signaling by mapk mutants 0.5174021131137461 0.0754796955387874 0.9398330520586996 1.0 1.0 2 Q99956 1 Irs mediated signalling 0.3472840725865123 0.0723208000750587 0.9423466119714224 1.0 1.0 4 P31751,P62993 2 Aurka activation by tpx2 0.3303313810095454 0.0596468836568933 0.9524368770568152 1.0 1.0 31 Q15691,O95684,P41208,Q96CS2,O43805,O75935,O94927 7 Regulation of tnfr1 signaling 0.4847731510254937 0.0558862798532817 0.9554324008385326 1.0 1.0 2 Q13546 1 Maturation of sars cov 2 spike protein 0.3118761743617919 0.0552994155027672 0.9558999278167136 1.0 1.0 11 P27824 1 Apc c cdc20 mediated degradation of cyclin b 0.3154418956595805 0.0548877300351649 0.9562279071568708 1.0 1.0 10 Q96DE5,Q9UJX3,Q9UJX5 3 Endosomal vacuolar pathway 0.3673643644763569 0.0546251185385335 0.9564371269314358 1.0 1.0 3 P10321 1 Noncanonical activation of notch3 0.4788688626476232 0.0531411538151145 0.9576194417563624 1.0 1.0 2 Q92542 1 Free fatty acids regulate insulin secretion 0.4673710379117546 0.0484105203722436 0.9613890750920644 1.0 1.0 2 O60488 1 Organelle biogenesis and maintenance 0.4350850985665335 0.0469015812466004 0.9625916678303064 1.0 1.0 95 Q15691,Q5XKP0,O75964,O43805,Q92973,O94927,Q9Y496,O75947,Q13505,Q9NX63,A6NIH7,P56385,Q96CS2,P54646,Q9Y512,O95684,Q9BUR5,P41208,P24539,O75935,O75431,Q13509,Q10713,P00846,Q6UXV4 25 Activated notch1 transmits signal to the nucleus 0.4620882535736639 0.0464914132485141 0.9629185779226516 1.0 1.0 2 Q92542 1 G2 phase 0.4568054692355646 0.0447214491967623 0.9643293368140412 1.0 1.0 2 P24941 1 Signaling by ntrk2 trkb 0.3521914827479077 0.0446959279141959 0.964349679510039 1.0 1.0 3 Q06124,P62993 2 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.3191006150411589 0.0394251929405604 0.9685513944585455 1.0 1.0 7 Q07812,P06493 2 G protein beta gamma signalling 0.3187788012599265 0.0383364075698591 0.9694194630680996 1.0 1.0 6 Q13153 1 Mtor signalling 0.2891628158505509 0.0376511473977409 0.9699658270809002 1.0 1.0 16 P54646,P62942,P31751 3 Aryl hydrocarbon receptor signalling 0.4257302672467453 0.0369177133653686 0.9705506161512572 1.0 1.0 2 Q15185 1 Intrinsic pathway of fibrin clot formation 0.4027346177750273 0.0334067489933233 0.973350227749739 1.0 1.0 2 Q07021 1 Formation of fibrin clot clotting cascade 0.4027346177750273 0.0334067489933233 0.973350227749739 1.0 1.0 2 Q07021 1 Regulation by c flip 0.394344313238047 0.0324823835423341 0.9740873645131868 1.0 1.0 2 Q13546 1 Caspase activation via death receptors in the presence of ligand 0.394344313238047 0.0324823835423341 0.9740873645131868 1.0 1.0 2 Q13546 1 Diseases of mitotic cell cycle 0.2962867507487616 0.0303553012435904 0.975783692852739 1.0 1.0 13 Q96DE5,Q9UJX5 2 Dap12 signaling 0.3520820385332607 0.0297771275715655 0.9762448002302936 1.0 1.0 2 P62993 1 Nef and signal transduction 0.3520820385332606 0.0297771275715655 0.9762448002302936 1.0 1.0 2 Q13177 1 Signaling by notch1 pest domain mutants in cancer 0.3146139755313895 0.0291573282127733 0.9767391139043547 1.0 1.0 6 Q13573,P63208 2 Defective cftr causes cystic fibrosis 0.3450824700899887 0.0257581487029794 0.9794502432598716 1.0 1.0 41 Q9BUN8,P49721,Q13438,Q9UL46,P61289,Q9UBV2 6 Signaling by flt3 fusion proteins 0.3084577114427814 0.0248683781927806 0.9801599499764846 1.0 1.0 4 Q01082,Q14789,P62993 3 Gab1 signalosome 0.2856698787690449 0.0211134444443987 0.9831551601702756 1.0 1.0 3 Q06124,P62993 2 Synthesis of pips at the golgi membrane 0.309752016617149 0.0149670697225668 0.9880584519935844 1.0 1.0 7 Q10713 1 Autophagy 0.3610082921005741 0.0143691932042365 0.9885354371143156 1.0 1.0 50 O94826,Q8N4H5,P21796,Q13509,Q8IWA4,Q15388,O96008,Q9NS69,Q9H9H4,P54646,Q99816 11 Signaling by egfr in cancer 0.2940332428844702 0.012472517725074 0.9900486286855132 1.0 1.0 4 Q16543 1 Constitutive signaling by egfrviii 0.2940332428844702 0.012472517725074 0.9900486286855132 1.0 1.0 4 Q16543 1 Constitutive signaling by ligand responsive egfr cancer variants 0.2940332428844702 0.012472517725074 0.9900486286855132 1.0 1.0 4 Q16543 1 Formation of incision complex in gg ner 0.2903888700314581 0.007943440773053 0.9936621178991454 1.0 1.0 13 P41208 1 Recycling of eif2 gdp 0.3053221288515415 0.0040549108430128 0.9967646581090084 1.0 1.0 7 Q9UI10,Q14232,P05198,P49770,Q13144,Q9NR50 6