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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:a86c1e7e235ecf1d77a7cdb52def74faeb430ce83ecb69d6e440e72f61452092
+size 73115

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 57,
+    "title": "Average number of proteins per term",
+    "value": 2.508771929824561
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C290/C290_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,8 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.8591481317861858	1.5816827626826886	0.1137220096961202	0.9989731950318712	0.3285750901976172	3	Q9H3G5	1
+Histidine acid phosphatase active site [IPR033379]	0.8607830950901	0.8932168423814926	0.3717410603394293	0.9999999999968818	0.6621637637296085	2	Q9NPH0	1
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.7775015537600918	0.6166595113671364	0.5374593324305095	1.0	0.6679815632987592	2	Q7LG56	1
+Peptidase S9, serine active site [IPR002471]	0.5453697949036802	0.1119449225976209	0.9108670773521016	1.0	0.9561136036792288	2	P48147	1
+ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]	0.5136730888750924	0.0838528952638746	0.9331733917288764	1.0	0.9561136036792288	2	P53597	1
+ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]	0.3315315720907362	0.0760998231911372	0.9393396808076636	1.0	0.9561136036792288	4	P21281,P06576	2
+Nucleoside diphosphate kinase, active site [IPR023005]	0.4505904288378012	0.0513060140520428	0.9590816758975912	1.0	0.9590816758975912	2	P15531	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA topoisomerase, type IA, active site [IPR023406]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine proteases, trypsin family, histidine active site [IPR018114]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK13", "CDK2", "CDK4", "CDK6", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK3", "MAPKAPK2", "MDH1", "MDH2", "MTMR2", "NCEH1", "NEK9", "NME1", "NME2", "OXCT1", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRPF4B", "PRSS3", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK2", "TIGAR", "TOP1", "TOP3A", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "ULK3", "UMPS", "VRK1", "VRK2", "WNK1"], "leading_proteins": ["ACP6", "ATP5B", "ATP6V1B2", "CPVL", "NME1", "PREP", "RRM2B", "SUCLG1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{"0": "Beta tubulin, autoregulation binding site [IPR013838]", "1": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:f4cdfa36c6c79de4f1cd884dd7cb470a4fcea8246fafdbad6832e2056cd5d4a1
+size 73108

interpro_binding_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.5
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C290/C290_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Beta tubulin, autoregulation binding site [IPR013838]	0.7233770484917559	1.7726614654603745	0.0762848200317898	0.9210742745284088	0.3051392801271593	7	Q9BVA1,P07437,Q13885,P68371,Q13509	5
+Peptidase M16, zinc-binding site [IPR001431]	0.6510751283989868	1.279587016550814	0.2006904184575058	0.9992293084306232	0.5838266718763805	5	O43847,Q10713	2
+EF-Hand 1, calcium-binding site [IPR018247]	0.415603929196138	1.0513884493932273	0.2930802186162644	0.9999848698127352	0.6698976425514616	39	P43304,Q9NWM8,P80303,O95302,Q96AY3,Q9BPX6,Q14257,Q9Y680,Q02818,O43852,Q9UBV8	11
+Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]	0.7591671845867043	0.5602761298624767	0.5752911064084874	0.9999999999987442	0.8766340669081712	2	P34897	1
+Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]	0.5577998756992015	0.1255369849129968	0.9000984468957278	1.0	0.9412690624324844	2	P50579	1

interpro_binding_site/selections.json

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+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APOBEC3C", "ARG2", "BPNT1", "CALM3", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK13", "CDK2", "CDK4", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LPCAT2", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K5", "MAPK1", "MAPK14", "MAPK3", "MAPKAPK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO19", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK1", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TAOK2", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "ULK3", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GPD2", "METAP2", "MICU1", "NRDC", "NUCB1", "NUCB2", "PEF1", "PMPCA", "RCN2", "SHMT2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4B"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Tubulin, conserved site [IPR017975]", "2": "Thioredoxin, conserved site [IPR017937]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:db6c7c735a1fe284a55f339e39ef2ab15fe334da87c1edfb93e5a290a0c1feee
+size 78517

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	5	8	1.9692450143194888	0.0489249620110809	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.1665589384625388	0.0479914252810258	0.0938999510605359	0.2183511668733661	2.285385949037992e-06

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 273,
+    "title": "Average number of proteins per term",
+    "value": 2.58974358974359
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C290/C290_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,26 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7639654324746266	1.9692450143194888	0.0489249620110809	0.9999988711510392	0.6923992664440041	8	P28070,P28074,Q99436,P20618,P49721	5
+Tetraspanin, conserved site [IPR018503]	0.8924463786136141	1.7077690560904262	0.0876792028942381	0.9999999999868088	0.6923992664440041	3	O60637,O43657	2
+Mini-chromosome maintenance, conserved site [IPR018525]	0.7008770396088044	1.6621701817425032	0.0964786569237419	0.9999999999990642	0.6923992664440041	6	Q14566	1
+Tubulin, conserved site [IPR017975]	0.6892901618929004	1.6211903261786562	0.104976826817938	0.9999999999999292	0.698992041982856	8	Q9BVA1,P23258,P04350,P07437,Q13885,P68371,Q13509	7
+Syntaxin/epimorphin, conserved site [IPR006012]	0.675151628303628	1.554081179572723	0.1201650538767702	0.9999999999999992	0.7290013268524062	8	O43752,Q9P2W9	2
+Thioredoxin, conserved site [IPR017937]	0.5786274249595279	1.1106241382068378	0.266730168303823	1.0	0.9231268467870588	12	O43396,Q9H1E5,Q99757,Q9H3N1,O95881	5
+Methylthiotransferase, conserved site [IPR020612]	0.8592293349906748	0.8878201585528119	0.3746374976132878	1.0	0.9901112675999107	2	Q5VV42	1
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.4931664463878403	0.6837390877472228	0.4941399363659751	1.0	0.9901112675999107	7	P49419,P05091,P51648	3
+Mrp, conserved site [IPR000808]	0.7924176507147329	0.6639262406851167	0.5067375204577318	1.0	0.9901112675999107	2	Q9Y5Y2	1
+Intermediate filament protein, conserved site [IPR018039]	0.4407241476420983	0.4447266346075729	0.6565173188583142	1.0	1.0	8	P07197,P07196	2
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.704785581106284	0.4063647436203949	0.6844746207003873	1.0	1.0	2	P40939	1
+Actin, conserved site [IPR004001]	0.6908017402113187	0.3705387394056519	0.7109811175029161	1.0	1.0	2	O96019	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.6740211311373565	0.329840624202335	0.7415203898534053	1.0	1.0	2	Q9BTY2	1
+Guanylate kinase, conserved site [IPR020590]	0.3911167099103453	0.2621070199338721	0.7932389348092368	1.0	1.0	6	Q14168	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.465029530618596	0.2354025067608268	0.8138963406238953	1.0	1.0	3	P09429,O15347	2
+Profilin conserved site [IPR027310]	0.5755127408328239	0.1475840237083732	0.8826710642513675	1.0	1.0	2	P07737	1
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.3497547785420163	0.1166210408875172	0.9071603632821056	1.0	1.0	7	P51648,P05091	2
+Ubiquitin interacting motif [IPR003903]	0.3490005939319914	0.1024097099727399	0.9184314767523424	1.0	1.0	4	O14964	1
+ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]	0.5136730888750924	0.0838528952638746	0.9331733917288764	1.0	1.0	2	P53597	1
+Zinc finger, RING-type, conserved site [IPR017907]	0.3393016409253999	0.0693006102513332	0.9447503399970234	1.0	1.0	9	P19474	1
+Phosphofructokinase, conserved site [IPR015912]	0.3229717127758851	0.0529618655521012	0.9577622919284144	1.0	1.0	3	Q01813,P17858	2
+UbiE/COQ5 methyltransferase, conserved site [IPR023576]	0.4425108763207075	0.0488779161917589	0.961016588148554	1.0	1.0	2	O43159	1
+Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]	0.3359229334990807	0.0361548654295748	0.9711588746089695	1.0	1.0	2	O60568	1
+Ribosomal protein S9, conserved site [IPR020574]	0.319763828464899	0.0358109125940135	0.971433131657607	1.0	1.0	2	P82933	1
+D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]	0.2883487307170413	0.0300935412357409	0.9759924517470048	1.0	1.0	4	P56545	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 14-18kDa subunit, conserved site [IPR020708]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Di-trans-poly-cis-decaprenylcistransferase-like, conserved site [IPR018520]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinate dehydrogenase, cytochrome b subunit, conserved site [IPR018495]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCD1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP1S1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHDDS", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPAD1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2E", "POLR2F", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RING1", "RIOK1", "RIOK2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SDHC", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX17", "STX18", "STX4", "STX5", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM13", "TRIM21", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP33", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACTL6A", "ALDH2", "ALDH3A2", "ALDH7A1", "CDKAL1", "CTBP2", "FUCA2", "HADHA", "HGS", "HMGB1", "HMGB3", "MCM6", "MPP2", "MRPS9", "NEFL", "NEFM", "NUBP2", "PFKL", "PFKP", "PFN1", "PLOD3", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB7", "RRP8", "STX18", "STX6", "SUCLG1", "TMX1", "TMX4", "TRIM21", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBG1", "TXN2", "TXNDC12", "TXNL1"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "Tubulin/FtsZ, GTPase domain [IPR003008]", "2": "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "3": "Peptidase M16, N-terminal [IPR011765]", "4": "Peptidase M16, C-terminal [IPR007863]", "5": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "6": "RNA recognition motif domain [IPR000504]", "7": "K Homology domain, type 1 [IPR004088]", "8": "Thioredoxin domain [IPR013766]", "9": "RNA recognition motif domain, eukaryote [IPR003954]", "10": "K Homology domain [IPR004087]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:9caa4c0cf66869565e1b0d31c58526749b6c9e57579ce81eaea6bee553a378d8
+size 146735

interpro_domain/df_merge.tsv

@@ -0,0 +1,8 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	4	6	2.3993334806122046	0.0164249485139058	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0189816476232036	0.0573151884822011	0.1116045715736199	5.632723326964323e-06	0.0001590313802548
+Aminopeptidase N-like , N-terminal domain [IPR045357]	2	6	2.2982739821100138	0.0215462002969184	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0003029012700725	0.0385773062479974	0.0025659780541994	0.0007272762906085	0.0053334351931861
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	2	6	2.2982739821100138	0.0215462002969184	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0003029012700725	0.0385773062479974	0.0025659780541994	0.0007272762906085	0.0053334351931861
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	1	5	2.092017924295751	0.0364369123165013	1.7985436893203883	6.618932038834951	-0.2560580222022892	0.3144815454028563	1.2849758471282229	0.9126568625608084	1.3559762153751562	0.266510476207785	0.1512282221515624	1.0	0.0849171013653387	0.0189506401306209	0.0677640175569944
+Polyketide synthase, enoylreductase domain [IPR020843]	1	5	2.081560326877054	0.0373826483778603	1.6189320388349515	6.283980582524272	0.4837477775906041	0.3583565743712875	1.2357658783365448	1.1656223303878015	1.2317099658487027	0.2921137785685181	0.1816142256550361	1.0	0.1027954944442906	0.0280420066437826	0.0971506673250001
+Ricin B, lectin domain [IPR000772]	1	5	2.0191508136448504	0.0434715467986621	1.4174757281553398	4.121359223300971	0.4009585995426035	0.4855340701643459	1.119329478938434	0.8894364404712861	0.9609441077042546	0.3172385378622441	0.2391782154315916	0.0711332726649859	0.1375212864755611	0.3090006421698555	0.16360549489043
+PWWP domain [IPR000313]	2	7	1.988929266944918	0.0467090108310395	3.3058252427184467	8.240291262135923	-0.3576134211980867	0.4993280051564587	1.9666306133740248	1.4508209636493494	0.9362848674719632	0.2971220842011314	0.0410064065816043	0.0847528009868792	0.1626892876910785	0.0088528623379573	0.0541965943180989

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 2549,
+    "title": "Average number of proteins per term",
+    "value": 2.1439780306002354
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C290/C290_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,202 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8666095375298553	2.3993334806122046	0.0164249485139058	1.0	0.5775397293884453	6	Q9UMX5,O15173,O43169,Q8WUJ1	4
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8430827880172248	2.2982739821100138	0.0215462002969184	1.0	0.5775397293884453	6	P55786,Q9UIQ6	2
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8430827880172248	2.2982739821100138	0.0215462002969184	1.0	0.5775397293884453	6	P55786,Q9UIQ6	2
+ERAP1-like C-terminal domain [IPR024571]	0.9117747426213936	2.169833953357106	0.0300194271965654	1.0	0.5775397293884453	4	P55786,Q9UIQ6	2
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.8382842733346607	2.092017924295751	0.0364369123165013	1.0	0.5775397293884453	5	Q8N4Q0	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.8357897641729981	2.081560326877054	0.0373826483778603	1.0	0.5775397293884453	5	Q8N4Q0	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.882873484770926	2.0560219187836672	0.0397804035118396	1.0	0.5775397293884453	4	Q8N4A0	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8759328358208934	2.0284970135537077	0.0425095477985382	1.0	0.5775397293884453	4	Q15629,Q96G23,Q96CP7	3
+Ricin B, lectin domain [IPR000772]	0.8209591842621304	2.0191508136448504	0.0434715467986621	1.0	0.5775397293884453	5	Q8N4A0	1
+PWWP domain [IPR000313]	0.7706761836414261	1.988929266944918	0.0467090108310395	1.0	0.5775397293884453	7	P51858,Q7Z4V5	2
+SET domain [IPR001214]	0.7924059774148168	1.8978770791158344	0.0577122764074471	1.0	0.5775397293884453	5	Q03164,Q9H7B4	2
+HDGF-related, PWWP domain [IPR035496]	0.937830276655267	1.87810131795627	0.0603673060825853	1.0	0.5775397293884453	3	P51858,Q7Z4V5	2
+GOLD domain [IPR009038]	0.7436308781905026	1.8578206381412905	0.0631944893338296	1.0	0.5775397293884453	6	Q9H3P7,Q9BVK6,Q9Y3B3,Q15363	4
+Zinc finger, CHHC-type [IPR012996]	0.9166925707180592	1.7990122319054231	0.072016745832518	1.0	0.5775397293884453	3	P55795,P31943	2
+EF-hand domain [IPR002048]	0.4234375337671978	1.7748165545562973	0.0759281819930475	1.0	0.5775397293884453	47	P43304,Q8IYU8,P80303,Q9NWM8,O95302,Q96AY3,Q9BPX6,Q14257,Q9Y680,Q02818,Q9UJS0,O43852,Q9UBV8	13
+FAD dependent oxidoreductase [IPR006076]	0.8097623334869782	1.7625400547177985	0.0779780950720625	1.0	0.5775397293884453	4	P43304	1
+Glycosyltransferase 2-like [IPR001173]	0.714734263668457	1.7259679433461166	0.0843531800345926	1.0	0.5775397293884453	6	Q8N4A0	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.7984224750242016	1.7163648747570537	0.0860952812435968	1.0	0.5775397293884453	4	P07197,P07196	2
+MCM N-terminal domain [IPR027925]	0.7008770396088044	1.6621701817425032	0.0964786569237419	1.0	0.5835226000858053	6	Q14566	1
+MCM OB domain [IPR033762]	0.7008770396088044	1.6621701817425032	0.0964786569237419	1.0	0.5835226000858053	6	Q14566	1
+MCM domain [IPR001208]	0.7008770396088044	1.6621701817425032	0.0964786569237419	1.0	0.5835226000858053	6	Q14566	1
+MCM, AAA-lid domain [IPR041562]	0.7008770396088044	1.6621701817425032	0.0964786569237419	1.0	0.5835226000858053	6	Q14566	1
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.730962987784382	1.6322628721444006	0.1026241210631409	1.0	0.5835226000858053	5	P98194,Q9HD20	2
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.6892901618929004	1.6211903261786562	0.104976826817938	1.0	0.588100948481152	8	Q9BVA1,P23258,P04350,P07437,Q13885,P68371,Q13509	7
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.6892901618929004	1.6211903261786562	0.104976826817938	1.0	0.588100948481152	8	Q9BVA1,P23258,P04350,P07437,Q13885,P68371,Q13509	7
+Potentiating neddylation domain [IPR005176]	0.8648405506540315	1.6032928918374514	0.1088700050843067	1.0	0.592448050722497	3	Q92564	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.8626049114081438	1.5948081867768618	0.1107551357589953	1.0	0.592448050722497	3	O15460,P13674	2
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8589411505250464	1.5808966179717046	0.1139016777547661	1.0	0.592448050722497	3	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8589411505250464	1.5808966179717046	0.1139016777547661	1.0	0.592448050722497	3	Q9Y282	1
+Post-SET domain [IPR003616]	0.7645989959087649	1.5777502884203665	0.1146229883362472	1.0	0.592448050722497	4	Q03164	1
+Zinc finger, RanBP2-type [IPR001876]	0.67771547142307	1.566276000138135	0.1172840170590334	1.0	0.592448050722497	8	Q92804,Q01844,P35637	3
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.7085415056157416	1.533949068686299	0.1250421830560062	1.0	0.600899469141594	5	P13674,O15460	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.7085415056157416	1.533949068686299	0.1250421830560062	1.0	0.600899469141594	5	P13674,O15460	2
+Tim10-like [IPR004217]	0.8380478706869696	1.5014188425608304	0.1332472633298798	1.0	0.6022114791274177	3	Q9Y5J6,P62072	2
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.8308983525023249	1.4741747798222686	0.1404345384378009	1.0	0.6066495080457033	3	Q5BKZ1,O43823	2
+MRH domain [IPR044865]	0.7253524383992784	1.4155659595216497	0.1569026237260904	1.0	0.6407638862732837	4	P20645,Q13438	2
+Peptidase M16, N-terminal [IPR011765]	0.6460271680428102	1.4098591731564132	0.1585812699644333	1.0	0.6427739232514861	7	P31930,O43847,O75439,P22695,Q10713	5
+Peptidase M16, C-terminal [IPR007863]	0.6460271680428102	1.4098591731564132	0.1585812699644333	1.0	0.6427739232514861	7	P31930,O43847,O75439,P22695,Q10713	5
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.6301775700342443	1.3610340421410587	0.1735029317284486	1.0	0.6617321755175478	11	Q9NWM8,O95302,Q96AY3,Q9Y680,P62942,P26885	6
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.8007460366801085	1.3591168423700009	0.1741095666246073	1.0	0.6617321755175478	3	O75431,Q13505	2
+Metaxin, glutathione S-transferase domain [IPR033468]	0.8007460366801085	1.3591168423700009	0.1741095666246073	1.0	0.6617321755175478	3	O75431,Q13505	2
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.6909428997439271	1.2726729436128748	0.2031341224719756	1.0	0.7035174975286219	4	Q8WVV9	1
+CBS domain [IPR000644]	0.641223212072179	1.2357739356362356	0.2165426059546518	1.0	0.7253181374223489	5	Q8NE01,P51798	2
+Zinc finger, CCHC-type [IPR001878]	0.6087059511093103	1.23033928876068	0.2185700776155235	1.0	0.7271513642397254	6	Q9NUD5	1
+NOPS [IPR012975]	0.7553621386384719	1.1860282165456877	0.2356111566248249	1.0	0.7501647046209847	3	Q15233,P23246	2
+EXPERA domain [IPR033118]	0.9425108763206896	1.1847512328025038	0.2361158193830397	1.0	0.7501647046209847	2	Q5BJF2	1
+Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]	0.937538844002479	1.1666930903532344	0.2433343342133977	1.0	0.7509191500120471	2	Q7Z4V5	1
+Prenylcysteine lyase [IPR010795]	0.9285270354257208	1.1340413515869423	0.2567772027696557	1.0	0.7707958278745738	2	Q9UHG3	1
+Syntaxin 6, N-terminal [IPR015260]	0.927284027346178	1.129546186272643	0.2586674975036596	1.0	0.7718775142147781	2	O43752	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.6514303482587015	1.1086351319347203	0.2675876159766337	1.0	0.7718775142147781	4	P16615,P20020,P98194	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.6514303482587015	1.1086351319347203	0.2675876159766337	1.0	0.7718775142147781	4	P16615,P20020,P98194	3
+FAD-binding domain, PCMH-type [IPR016166]	0.9173399627097468	1.093666083504881	0.2741014545977656	1.0	0.7724949428734251	2	Q15392	1
+FAD linked oxidase, N-terminal [IPR006094]	0.9173399627097468	1.093666083504881	0.2741014545977656	1.0	0.7724949428734251	2	Q15392	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.9170292106898614	1.0925472720013352	0.2745926243503684	1.0	0.7724949428734251	2	Q15067	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.9111249223119948	1.071319883078164	0.2840256226066708	1.0	0.7784810851964494	2	O60506	1
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9089496581727674	1.0635141378407027	0.2875488572328815	1.0	0.7789182115691976	2	Q8N2A8	1
+Reticulon [IPR003388]	0.6397948217009877	1.0605129026048268	0.2889113232231803	1.0	0.7801652702062162	4	O95197	1
+B-box-type zinc finger [IPR000315]	0.593012969645031	1.021587565057791	0.3069761455419426	1.0	0.7829131546929614	5	P19474	1
+Major facilitator superfamily domain [IPR020846]	0.5929364549129588	1.0212488578453964	0.3071365497805252	1.0	0.7829131546929614	5	Q9H2V7,P53985,Q8NHS3	3
+Death domain [IPR000488]	0.7012744793285552	0.9817661167509508	0.3262150843653149	1.0	0.7971336260201788	3	Q96FV9,Q13546	2
+CARG-binding factor, N-terminal [IPR012956]	0.884711000621504	0.9771496695897296	0.3284950608416805	1.0	0.7997458549049128	2	Q99729	1
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.5546594980341689	0.9748744037561532	0.3296225642155841	1.0	0.8000041704456738	9	O15254,Q15067	2
+Glutamine amidotransferase type 2 domain [IPR017932]	0.6946648328159678	0.957103732499638	0.3385148998738088	1.0	0.8074013612601867	3	Q06203	1
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.8781852082038446	0.954114564847622	0.3400256543269897	1.0	0.8085124933577396	2	P13674	1
+LEM domain [IPR003887]	0.5451751951495484	0.9297028013878322	0.3525249836341366	1.0	0.8183845020796122	6	Q86XL3,P42166	2
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.867308887507769	0.915958103730338	0.3596888697121625	1.0	0.8282266747030734	2	Q15418	1
+TRAM domain [IPR002792]	0.8592293349906748	0.8878201585528119	0.3746374976132878	1.0	0.8421084492206973	2	Q5VV42	1
+Methylthiotransferase, N-terminal [IPR013848]	0.8592293349906748	0.8878201585528119	0.3746374976132878	1.0	0.8421084492206973	2	Q5VV42	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.8573648228713506	0.8813535089898277	0.3781265126349473	1.0	0.8464898858255526	2	Q14011	1
+GMP phosphodiesterase, delta subunit [IPR008015]	0.8520820385332311	0.8630883430459274	0.3880888965861575	1.0	0.8531863725150682	2	A6NIH7	1
+CAP Gly-rich domain [IPR000938]	0.6670811314889602	0.8552516661167581	0.3924118391197173	1.0	0.8549211777061192	3	Q15813,Q99426	2
+Radical SAM [IPR007197]	0.6576309630958381	0.8208335245375759	0.4117410999786886	1.0	0.8688826462282886	3	Q5VV42	1
+Elp3/MiaB/NifB [IPR006638]	0.6576309630958381	0.8208335245375759	0.4117410999786886	1.0	0.8688826462282886	3	Q5VV42	1
+BRICHOS domain [IPR007084]	0.8334369173399464	0.7993506949219636	0.4240870912563048	1.0	0.8759885753686125	2	Q9Y287	1
+GYF domain [IPR003169]	0.8300186451211948	0.7877984978506927	0.4308145798631526	1.0	0.8806306047082406	2	O95400	1
+Tudor domain [IPR002999]	0.5048567919828666	0.7353147766646693	0.4621478109539763	1.0	0.9047732489413868	8	Q16637,Q14739,Q9Y2W6	3
+Protein kinase, C-terminal [IPR017892]	0.5252690266433484	0.7264061383973959	0.4675898292401446	1.0	0.9098370036130752	5	P51812,Q15418	2
+Tim44-like domain [IPR007379]	0.8067122436295859	0.7102777889136691	0.4775318905493695	1.0	0.915137238642234	2	Q9BRJ2	1
+SH2 domain [IPR000980]	0.4941942181184634	0.6834847011346825	0.4943006141858412	1.0	0.9250897691334136	9	P46108,P42224,P62993,P40763	4
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.7967681789931663	0.6779289381863768	0.4978167507790596	1.0	0.925679469252453	2	Q5T9A4	1
+RBM1CTR [IPR012604]	0.7955251709136137	0.6739186030705524	0.5003630642600165	1.0	0.9259629717339566	2	P38159	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.7952144188937257	0.6729172068842061	0.5009999646557466	1.0	0.9260688251685992	2	Q92945	1
+FAD/NAD(P)-binding domain [IPR023753]	0.4809491523923853	0.632827288398378	0.5268464345963892	1.0	0.9361794874978676	6	O95831	1
+OTU domain [IPR003323]	0.6020672530525663	0.6254066675396848	0.5317041871937089	1.0	0.9361794874978676	3	Q96FW1	1
+Survival motor neuron [IPR010304]	0.7728402734617814	0.6021376825574322	0.5470824929902602	1.0	0.939559123920176	2	Q16637	1
+OCRE domain [IPR041591]	0.764139216904898	0.5753678912682658	0.5650425148016489	1.0	0.95385706898734	2	P98175	1
+Serine hydroxymethyltransferase-like domain [IPR039429]	0.7591671845867043	0.5602761298624767	0.5752911064084874	1.0	0.9582854793434116	2	P34897	1
+STAT transcription factor, protein interaction [IPR013799]	0.7355500310752074	0.4907898442661059	0.6235750936910485	1.0	0.9781494854267584	2	P42224	1
+STAT transcription factor, DNA-binding [IPR013801]	0.7355500310752074	0.4907898442661059	0.6235750936910485	1.0	0.9781494854267584	2	P42224	1
+STAT transcription factor, all-alpha domain [IPR013800]	0.7355500310752074	0.4907898442661059	0.6235750936910485	1.0	0.9781494854267584	2	P42224	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.7336855189558789	0.4854681904588874	0.6273442715411506	1.0	0.9802748976900584	2	Q9BQ67	1
+Aldehyde dehydrogenase domain [IPR015590]	0.4471465425029919	0.4647113874471266	0.6421381524419094	1.0	0.9855947511807456	10	P49419,P05091,P51648	3
+FCP1 homology domain [IPR004274]	0.550202051600874	0.4584364005137122	0.6466389451073549	1.0	0.9855947511807456	3	Q05D32,Q8WVY7	2
+Intermediate filament, rod domain [IPR039008]	0.4407241476420983	0.4447266346075729	0.6565173188583142	1.0	0.9881201100957052	8	P07197,P07196	2
+Sterile alpha motif domain [IPR001660]	0.4362891341365683	0.4257764782593749	0.6702707281594174	1.0	0.9915961033536592	8	Q9Y3Z3	1
+DDHD domain [IPR004177]	0.7106898694841408	0.4219877103942669	0.6730339877844849	1.0	0.992398037574004	2	O94830	1
+RNA recognition motif domain [IPR000504]	0.3747074938555695	0.417748514107623	0.6761309977258108	1.0	0.9925813061760927	117	P43243,P31942,P09651,P52597,Q96PK6,Q96E39,P51991,O15047,Q8IZ69,P23246,O43390,O60506,Q01085,P62995,Q93062,Q14011,Q92804,Q8WUA2,O14979,Q16630,P31943,P98179,P35637,Q8WVV9,Q13151,P84103,Q01844,Q13242,P38159,Q9BWF3,P98175,Q07955,Q99729,P55795,P22626,Q14103,Q9UHX1,Q15233,P14866	39
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.704785581106284	0.4063647436203949	0.6844746207003873	1.0	0.9925813061760927	2	P40939	1
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.704785581106284	0.4063647436203949	0.6844746207003873	1.0	0.9925813061760927	2	P40939	1
+Thioredoxin-like fold [IPR012336]	0.7044748290863958	0.4055504873889206	0.6850729150932919	1.0	0.9925813061760927	2	Q8NBF2	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.6991920447482978	0.3918326838565904	0.6951818439629185	1.0	0.9925813061760927	2	Q9Y305	1
+K Homology domain, type 1 [IPR004088]	0.4187958082096576	0.3793773851002235	0.7044076416703868	1.0	0.9925813061760927	22	Q96PU8,P51114,Q92945,Q96AE4,Q9Y6M1,P61978,Q9Y2W6,Q07666,Q9NQT5,Q06787	10
+Sin3, C-terminal [IPR031693]	0.6889372280919899	0.3658906900326971	0.7144466436698971	1.0	0.9925813061760927	2	Q96ST3	1
+Histone deacetylase interacting domain [IPR013194]	0.6889372280919899	0.3658906900326971	0.7144466436698971	1.0	0.9925813061760927	2	Q96ST3	1
+EB1, C-terminal [IPR004953]	0.6845866998135466	0.3551662036113531	0.7224650819524239	1.0	0.9925813061760927	2	Q15555	1
+CRK, N-terminal SH3 domain [IPR035457]	0.6796146674953254	0.3431198947812485	0.7315082647831814	1.0	0.9925813061760927	2	P46108	1
+CRK, C-terminal SH3 domain [IPR035458]	0.6796146674953254	0.3431198947812485	0.7315082647831814	1.0	0.9925813061760927	2	P46108	1
+EF-hand, Ca insensitive [IPR014837]	0.4486940298507405	0.3404851357932659	0.7334912147622061	1.0	0.9925813061760927	4	P12814,Q13813,O43707	3
+Peptidase M28 [IPR007484]	0.5065803782914675	0.3347958153263358	0.7377791174190551	1.0	0.9925813061760927	3	P02786	1
+Fibronectin type II domain [IPR000562]	0.6749533871970248	0.3320335549501194	0.7398639217610643	1.0	0.9925813061760927	2	P11717	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.6740211311373565	0.329840624202335	0.7415203898534053	1.0	0.9925813061760927	2	Q9BTY2	1
+Rhodanese-like domain [IPR001763]	0.4233902241610297	0.3279133318541662	0.742977193227413	1.0	0.9925813061760927	5	P25325	1
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.410639547479931	0.3010980691507553	0.7633397133441409	1.0	0.9925813061760927	12	P78417	1
+Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]	0.6559975139838494	0.2890783130638111	0.7725214491112844	1.0	0.9925813061760927	2	Q9Y237	1
+PTB/PI domain [IPR006020]	0.4883431768728717	0.2887605835173032	0.7727645975116264	1.0	0.9925813061760927	3	O60343,Q9UKG1	2
+Bromodomain [IPR001487]	0.4061024604624792	0.2859488422803912	0.7749173040991446	1.0	0.9925813061760927	11	Q03164	1
+MHC class I-like antigen recognition-like [IPR011161]	0.6420136730888669	0.2596589357811982	0.7951268708505401	1.0	0.9925813061760927	2	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.6420136730888669	0.2596589357811982	0.7951268708505401	1.0	0.9925813061760927	2	P10321	1
+Immunoglobulin C1-set [IPR003597]	0.6420136730888669	0.2596589357811982	0.7951268708505401	1.0	0.9925813061760927	2	P10321	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.6420136730888669	0.2596589357811982	0.7951268708505401	1.0	0.9925813061760927	2	P10321	1
+L27 domain, C-terminal [IPR014775]	0.4016110562276761	0.2563261787907501	0.7976989845757956	1.0	0.9925813061760927	5	Q14168	1
+L27 domain [IPR004172]	0.4016110562276761	0.2563261787907501	0.7976989845757956	1.0	0.9925813061760927	5	Q14168	1
+Glycogen synthase kinase 3, catalytic domain [IPR039192]	0.6330018645121114	0.2417537969382969	0.8089709417311743	1.0	0.9925813061760927	2	P49841	1
+RAD23A/RAD23B, UBA1 domain [IPR041811]	0.6215040397762619	0.2201323972110115	0.8257680442622941	1.0	0.9925813061760927	2	P54725	1
+XPC-binding domain [IPR015360]	0.6215040397762619	0.2201323972110115	0.8257680442622941	1.0	0.9925813061760927	2	P54725	1
+Thioredoxin domain [IPR013766]	0.3778939341969416	0.2190009179050153	0.8266493327383393	1.0	0.9925813061760927	26	Q6ZRP7,O43396,Q9H1E5,P07237,Q99757,Q9H3N1,O95881	7
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.4532172831830949	0.2108551392961525	0.8330003107114332	1.0	0.9925813061760927	3	P31689,Q96EY1	2
+Cold-shock protein, DNA-binding [IPR002059]	0.4008084577114367	0.208190010141621	0.8350806084550051	1.0	0.9925813061760927	4	Q9Y2V2,O75534,P67809	3
+Cold shock domain [IPR011129]	0.4008084577114367	0.208190010141621	0.8350806084550051	1.0	0.9925813061760927	4	Q9Y2V2,O75534,P67809	3
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.3970771144278525	0.1992074585994866	0.8421004652326747	1.0	0.9925813061760927	4	Q13596,Q9Y5X3,O60749	3
+ZU5 domain [IPR000906]	0.5988191423244225	0.1815556077578043	0.8559314896147852	1.0	0.9925813061760927	2	Q12955	1
+NOT2/NOT3/NOT5, C-terminal [IPR007282]	0.5870105655686877	0.1636296023584471	0.8700227394756834	1.0	0.9925813061760927	2	Q9NZN8	1
+Cold-shock (CSD) domain [IPR019844]	0.4230649673609031	0.1561113637717408	0.875945241191401	1.0	0.9925813061760927	3	O75534,P67809	2
+B30.2/SPRY domain [IPR001870]	0.3702164626972107	0.1509421039654419	0.8800213868017184	1.0	0.9925813061760927	11	P19474,Q96S59	2
+SPRY domain [IPR003877]	0.3702164626972107	0.1509421039654419	0.8800213868017184	1.0	0.9925813061760927	11	P19474,Q96S59	2
+Gelsolin-like domain [IPR007123]	0.3601866251943952	0.1396952046170675	0.8889008154158384	1.0	0.9925813061760927	5	O95486,Q13045,P53992,Q15436	4
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.5668116842759593	0.1363537955409634	0.8915415982645236	1.0	0.9925813061760927	2	O94979	1
+Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]	0.5546923555003237	0.1219962361720413	0.9029019991057592	1.0	0.997588289331767	2	Q9UKA9	1
+Zinc finger, Sec23/Sec24-type [IPR006895]	0.3600746268656647	0.1215323059127093	0.9032694279237812	1.0	0.997588289331767	4	O95486,P53992,Q15436	3
+Sec23/Sec24, trunk domain [IPR006896]	0.3600746268656647	0.1215323059127093	0.9032694279237812	1.0	0.997588289331767	4	O95486,P53992,Q15436	3
+Sec23/Sec24, helical domain [IPR006900]	0.3600746268656647	0.1215323059127093	0.9032694279237812	1.0	0.997588289331767	4	O95486,P53992,Q15436	3
+Sec23/Sec24 beta-sandwich [IPR012990]	0.3600746268656647	0.1215323059127093	0.9032694279237812	1.0	0.997588289331767	4	O95486,P53992,Q15436	3
+3'-5' exonuclease domain [IPR002562]	0.5525170913611065	0.1195747255608818	0.9048200421247856	1.0	0.9984356222407268	2	Q9NVH0	1
+PABP, RNA recognition motif 2 [IPR045305]	0.5459912989434564	0.1125886837429518	0.9103566570654976	1.0	1.0	2	P11940	1
+PUA domain [IPR002478]	0.3922909543052639	0.1120950280531328	0.9107480596198152	1.0	1.0	3	Q9ULC4,Q9Y221	2
+Class II aldolase/adducin N-terminal [IPR001303]	0.5416407706650198	0.1081602091695542	0.913868608213386	1.0	1.0	2	Q9UEY8	1
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.3462816212728984	0.1065295711900348	0.9151621944787344	1.0	1.0	7	P60900	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.3827052840292135	0.1007739957577436	0.919729870111346	1.0	1.0	3	Q9UL46	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.3827052840292135	0.1007739957577436	0.919729870111346	1.0	1.0	3	Q9UL46	1
+Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]	0.5326289620882673	0.0995559502792937	0.92069686659727	1.0	1.0	2	Q9H4A3	1
+TGS [IPR004095]	0.3425987633658255	0.0960857732288921	0.9234524503420194	1.0	1.0	7	Q9BW92	1
+Dynamin, GTPase domain [IPR001401]	0.3411069651741212	0.0899416505278926	0.9283335829232296	1.0	1.0	4	P50570,O00429,O60313	3
+RNA recognition motif domain, eukaryote [IPR003954]	0.3547248335002533	0.0878245910680327	0.9300160924353922	1.0	1.0	13	Q01085,Q14011,Q96E39,Q9UHX1,P38159	5
+Major sperm protein (MSP) domain [IPR000535]	0.3695990052844331	0.0870483363418424	0.9306330910487856	1.0	1.0	3	Q9P0L0,Q8NHP6	2
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.5158483530143079	0.0854964787155599	0.9318666948010212	1.0	1.0	2	P07948	1
+CoA-binding [IPR003781]	0.5136730888750924	0.0838528952638746	0.9331733917288764	1.0	1.0	2	P53597	1
+Thioesterase domain [IPR006683]	0.5114978247358754	0.0822488929150265	0.934448794195888	1.0	1.0	2	O00154	1
+Fzo/mitofusin HR2 domain [IPR006884]	0.5059042883778863	0.0783026822283859	0.9375872839063396	1.0	1.0	2	Q8IWA4	1
+Phosphopantetheine binding ACP domain [IPR009081]	0.504661280298337	0.0774600162971932	0.9382575980405063	1.0	1.0	2	O14561	1
+Acyl transferase [IPR014043]	0.5046612802983368	0.0774600162971932	0.9382575980405063	1.0	1.0	2	Q8IVS2	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.3446143007781426	0.0763815993324539	0.9391155084406336	1.0	1.0	10	O43752	1
+ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]	0.3315315720907362	0.0760998231911372	0.9393396808076636	1.0	1.0	4	P21281,P06576	2
+ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]	0.3315315720907362	0.0760998231911372	0.9393396808076636	1.0	1.0	4	P21281,P06576	2
+Domain of unknown function DUF4217 [IPR025313]	0.3462853590301568	0.0673265839366435	0.9463217139776507	1.0	1.0	3	Q8NHQ9,Q9NVP1	2
+BAT2, N-terminal [IPR009738]	0.4853946550652737	0.0659066463927065	0.9474521490343012	1.0	1.0	2	Q9Y520	1
+RAP domain [IPR013584]	0.4819763828465044	0.0641368543525321	0.9488612567124046	1.0	1.0	2	Q7L8L6	1
+FAST kinase-like protein, subdomain 2 [IPR013579]	0.4819763828465044	0.0641368543525321	0.9488612567124046	1.0	1.0	2	Q7L8L6	1
+FAST kinase leucine-rich [IPR010622]	0.4819763828465044	0.0641368543525321	0.9488612567124046	1.0	1.0	2	Q7L8L6	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.4816656308266164	0.0639799149447044	0.9489862195884388	1.0	1.0	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.4816656308266164	0.0639799149447044	0.9489862195884388	1.0	1.0	2	A0FGR8	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.4816656308266164	0.0639799149447044	0.9489862195884388	1.0	1.0	2	A0FGR8	1
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.4816656308266164	0.0639799149447044	0.9489862195884388	1.0	1.0	2	A0FGR8	1
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.4816656308266164	0.0639799149447044	0.9489862195884388	1.0	1.0	2	A0FGR8	1
+Peptidase S8/S53 domain [IPR000209]	0.4766935985084035	0.0615563952684486	0.950916102586199	1.0	1.0	2	P29144	1
+Copine, C-terminal [IPR010734]	0.4658172778123139	0.0568041864657814	0.9547011790077092	1.0	1.0	2	Q99829	1
+Copine, C2B domain [IPR037768]	0.4658172778123139	0.0568041864657814	0.9547011790077092	1.0	1.0	2	Q99829	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.3291459122463281	0.0562931538338214	0.9551082726375146	1.0	1.0	3	Q1KMD3	1
+BTB/POZ domain [IPR000210]	0.3143656716417832	0.0547077049812431	0.9563713308703912	1.0	1.0	4	Q96CX2,Q9P2R3,Q08380	3
+Sorting nexin, N-terminal [IPR005329]	0.4599129894344481	0.0545206451476107	0.9565203606014678	1.0	1.0	2	O60749	1
+Phosphofructokinase domain [IPR000023]	0.3229717127758851	0.0529618655521012	0.9577622919284144	1.0	1.0	3	Q01813,P17858	2
+Nucleoside diphosphate kinase-like domain [IPR034907]	0.4505904288378012	0.0513060140520428	0.9590816758975912	1.0	1.0	2	P15531	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.3139151225840861	0.048636957460395	0.9612086170100058	1.0	1.0	3	P21912	1
+EF hand associated, type-2 [IPR013567]	0.4356743318831718	0.0470611944964936	0.9624644553550714	1.0	1.0	2	Q8IXI1	1
+EF hand associated, type-1 [IPR013566]	0.4356743318831718	0.0470611944964936	0.9624644553550714	1.0	1.0	2	Q8IXI1	1
+MIRO domain [IPR020860]	0.4356743318831718	0.0470611944964936	0.9624644553550714	1.0	1.0	2	Q8IXI1	1
+Ku70/Ku80, N-terminal alpha/beta [IPR005161]	0.4182722187694404	0.0433045680372881	0.965458749872967	1.0	1.0	2	P12956	1
+Ku70/Ku80 C-terminal arm [IPR005160]	0.4182722187694404	0.0433045680372881	0.965458749872967	1.0	1.0	2	P12956	1
+Ku70/Ku80 beta-barrel domain [IPR006164]	0.4182722187694404	0.0433045680372881	0.965458749872967	1.0	1.0	2	P12956	1
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.4030453697949161	0.040881903180004	0.9673900445555368	1.0	1.0	2	P43246	1
+Aminotransferase, class I/classII [IPR004839]	0.3165188740336091	0.0396759302584582	0.9683514914343044	1.0	1.0	6	O15269	1
+GRAM domain [IPR004182]	0.2834939384519804	0.038299450499514	0.969448928904188	1.0	1.0	3	Q969T9,Q66K14	2
+Ribosomal protein S10 domain [IPR027486]	0.2806963009014666	0.0376229651918342	0.9699882973071672	1.0	1.0	3	P60866,P82664	2
+Rap/Ran-GAP domain [IPR000331]	0.3436917339962815	0.0363875198448044	0.9709733653115789	1.0	1.0	2	P49815	1
+Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]	0.3359229334990807	0.0361548654295748	0.9711588746089695	1.0	1.0	2	O60568	1
+Exosome complex component, N-terminal domain [IPR025721]	0.3104412678682531	0.0356779543955678	0.9715391492022352	1.0	1.0	2	Q9Y3B2	1
+D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]	0.2883487307170413	0.0300935412357409	0.9759924517470048	1.0	1.0	4	P56545	1
+D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]	0.2883487307170413	0.0300935412357409	0.9759924517470048	1.0	1.0	4	P56545	1
+Glutamine amidotransferase [IPR017926]	0.2742537313432776	0.0202688527321151	0.9838289025997032	1.0	1.0	4	P17812,P49915,Q9NRF8	3
+Importin-alpha, importin-beta-binding domain [IPR002652]	0.253894603385438	0.0097589588257656	0.9922136010161802	1.0	1.0	4	P52292	1
+FERM adjacent (FA) [IPR014847]	0.2889580093312559	0.0086658122033894	0.9930857687750718	1.0	1.0	5	O94887,Q9HCM4,P11171,O43491	4
+K Homology domain [IPR004087]	0.3357999485584336	0.0037598815036976	0.9970000556659764	1.0	1.0	22	Q96PU8,P51114,Q92945,Q96AE4,Q9Y6M1,P61978,Q9Y2W6,Q07666,Q06787	9

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]"}