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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:7bf74ed0a5dbc3cccd6328d17d5f5a609c9270ab3fd0c036a313466e547297b5
+size 71519

interpro_active_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3052,
+    "annotations_size": 53,
+    "title": "Average number of proteins per term",
+    "value": 2.7735849056603774
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C309/C309_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,12 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Cysteine peptidase, asparagine active site [IPR025661]	0.9839344262295074	2.186964571842265	0.0287451104034481	0.7868621581837545	0.2651047513821369	2	P07858	1
+Cysteine peptidase, histidine active site [IPR025660]	0.9839344262295074	2.186964571842265	0.0287451104034481	0.7868621581837545	0.2651047513821369	2	P07858	1
+Peptidase S9, serine active site [IPR002471]	0.933442622950812	1.9839181237699	0.0472649681504331	0.9231713637548832	0.2783381457747729	2	P48147	1
+Cysteine peptidase, cysteine active site [IPR000169]	0.887562139263782	1.7962660911326394	0.0724522079998453	0.981429496260229	0.3324513907057889	6	Q13867,P07858,P07384	3
+Nucleoside diphosphate kinase, active site [IPR023005]	0.685470646113476	0.9543405452655794	0.3399112908371715	0.99999999972526	0.5732888391142203	3	Q13232,P15531	2
+Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]	0.6806713324525288	0.9347466058096509	0.3499189022637283	0.9999999998777414	0.5732888391142203	3	P09622	1
+Glycosyl hydrolases family 31, active site [IPR030458]	0.6465573770491777	0.8020018990412262	0.4225518597357496	0.9999999999997708	0.6052769882701279	2	P10253	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.5045901639344283	0.305188201975915	0.7602228175176093	1.0	0.8394126943423603	2	P18669	1
+Tyrosine-protein kinase, active site [IPR008266]	0.4698196839949485	0.1951258503500958	0.8452944258671942	1.0	0.9142980524685976	7	P07948,Q15375,Q05397	3
+Malate dehydrogenase, active site [IPR001252]	0.4016393442622935	0.085471795275592	0.9318863175086992	1.0	0.9700828048466252	2	P40926	1
+L-lactate dehydrogenase, active site [IPR018177]	0.3580327868852411	0.0375044339603197	0.9700828048466252	1.0	0.9700828048466252	2	P00338	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT1", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CASP2", "CASP3", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EGFR", "EIF2AK2", "EPHA7", "FASN", "G6PD", "GAA", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K4", "MAPK1", "MAPK3", "MASTL", "MDH1", "MDH2", "MTMR2", "MTMR6", "NEK9", "NME1", "NME2", "NME3", "PAK2", "PBK", "PGAM1", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCD", "PRPF4B", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["BLMH", "CAPN1", "CTSB", "DLD", "EPHA7", "GAA", "LDHA", "LYN", "MDH2", "NME1", "NME3", "PGAM1", "PREP", "PTK2"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:83d7cf17d71992ddd8f6eba99ffdfc84f0081fa4e54118b9d2d214269b4061b6
+size 68579

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3052,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.580645161290323
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C309/C309_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Biotin-binding site [IPR001882]	0.9625984251968502	2.103284148389534	0.0354409382649176	0.6732665572461318	0.3381283783112428	4	Q96RQ3,P05165,P11498	3
+Peptidase M16, zinc-binding site [IPR001431]	0.3547751887102005	0.0280413708899642	0.9776291549097208	1.0	1.0	5	P14735,P22695,O43847,O75439	4
+Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]	0.3075409836065498	0.0087161321079707	0.993045620816386	1.0	1.0	2	P50579	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT1", "AKT2", "APEX1", "APOBEC3C", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CETN2", "CHEK1", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EGFR", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LRP2", "LYN", "MACF1", "MAP2K1", "MAP2K4", "MAP4K5", "MAPK1", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO9B", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKN1", "PKN2", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TBK1", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["IDE", "MCCC1", "METAP2", "NRDC", "PC", "PCCA", "PMPCB", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "WD40 repeat, conserved site [IPR019775]", "2": "Zinc finger, PHD-type, conserved site [IPR019786]", "3": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:3f71b0b0564d88ceb3e876e703a244ed582537dd9f8f15706a3bbfb1b43308d6
+size 77200

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_50	pval_100	pval_250	pval_500
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	1	5	1.9764218625488497	0.0481070174450719	1.8349514563106797	4.495145631067961	-0.0268416016144192	0.3268992301433215	1.18113888908689	0.4999764345469411	1.4254920509394828	0.309635855483207	0.0001415387755307	0.0006757625701886	0.0049685652699959	0.0202763085379925

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3052,
+    "annotations_size": 278,
+    "title": "Average number of proteins per term",
+    "value": 2.6546762589928057
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C309/C309_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,32 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Sterol reductase, conserved site [IPR018083]	0.9708196721311452	2.134560200963238	0.0327969512948302	0.9999058308637536	0.4404099221296665	2	Q9UBM7	1
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.9312327204663764	1.97642186254885	0.0481070174450719	0.9999988844249368	0.4404099221296665	5	P48735	1
+Serpin, conserved site [IPR023795]	0.9073017607643736	1.8771824221377855	0.0604930958488942	0.9999999707454572	0.4404099221296665	4	P50452	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.8774638633376999	1.7624829074359327	0.0779877417838983	0.9999999998426736	0.4404099221296665	8	P49721,Q99436,P20618,P28074,P25789,P28072,P28070	7
+Purine phosphorylase, family 2, conserved site [IPR018099]	0.8649180327868718	1.7032821266000402	0.0885152837859806	0.9999999999935384	0.4404099221296665	2	P00491	1
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.854185485291455	1.656651619228355	0.097589929714289	0.9999999999995998	0.4473813761796441	4	P42345,Q9UBF8	2
+Hexapeptide transferase, conserved site [IPR018357]	0.768524590163939	1.3021647541935495	0.1928600709932859	1.0	0.5205349488945	2	Q9Y5P6	1
+Inositol monophosphatase, conserved site [IPR020550]	0.7291803278688376	1.1383747645187778	0.2549640268907627	1.0	0.588930715506494	2	O95861	1
+Ribosomal protein L3, conserved site [IPR019926]	0.7229508196721298	1.112556206058665	0.2658990779958854	1.0	0.5913595494628492	2	P39023	1
+Haem oxygenase conserved site [IPR018207]	0.7039344262295061	1.0340612545454824	0.3011075280246276	1.0	0.6079003003425206	2	P09601	1
+Ribosomal protein L30, conserved site [IPR018038]	0.6901639344262334	0.977603655631585	0.3282703886240665	1.0	0.6293735726723483	2	P18124	1
+Glycosyl hydrolases family 31, conserved site [IPR030459]	0.6465573770491777	0.8020018990412262	0.4225518597357496	1.0	0.7206712699787631	2	P10253	1
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.6363934426229411	0.7620045558659239	0.4460572850612532	1.0	0.7316362227572183	2	P11216	1
+DNA topoisomerase, type IIA, conserved site [IPR018522]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7316362227572183	2	P11388	1
+Ribosomal protein S5, N-terminal, conserved site [IPR018192]	0.618360655737693	0.6921794520048508	0.4888246410576	1.0	0.7405722937013998	2	P82675	1
+Calreticulin/calnexin, conserved site [IPR018124]	0.5948305930143465	0.5987069380896903	0.549368329722228	1.0	0.7679440203903758	3	P27824	1
+Cyclic nucleotide-binding, conserved site [IPR018488]	0.59311475409836	0.597367939334515	0.5502617540386048	1.0	0.7679440203903758	2	P10644	1
+Phosphofructokinase, conserved site [IPR015912]	0.5883578995216906	0.5749408354414138	0.5653313112526459	1.0	0.7780302204368097	3	P17858	1
+Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]	0.568567676369369	0.50418752987544	0.6141296025590384	1.0	0.7981775222672093	3	O60568	1
+Guanylate kinase, conserved site [IPR020590]	0.5541887006682693	0.450017904454849	0.6526975305504064	1.0	0.8173419526712296	4	Q9NZW5	1
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.5442622950819723	0.4268622471577951	0.6694796647052135	1.0	0.8271793190579971	2	P29692	1
+Bromodomain, conserved site [IPR018359]	0.5250902784012207	0.3411608925330869	0.7329824622748018	1.0	0.8541723566513196	9	Q9BXF3,Q9NRL2	2
+Cadherin conserved site [IPR020894]	0.4762158709865449	0.2167646074032894	0.828391795356108	1.0	0.917501669756964	5	Q08554,Q14574	2
+Zinc finger, RING-type, conserved site [IPR017907]	0.4641216590728549	0.1706682814178373	0.8644846046206505	1.0	0.9387762503302376	13	O95376,P19474	2
+WD40 repeat, conserved site [IPR019775]	0.4309761078940306	0.1541009949028735	0.8775301038322616	1.0	0.9455556932766228	48	O75530,Q9GZL7,O75717,Q9UFC0,Q8TEQ6,Q8NFH4,Q9Y5J1,Q9BV38,O43172,Q9BQA1,P53621,O60508,P63244,Q9ULV4,Q13347,P61964,Q96DI7,O43660,P78406,Q9HAD4,Q9GZS3,O43815,P43034	23
+Thioredoxin, conserved site [IPR017937]	0.4498898104884496	0.143354777191293	0.8860099965788741	1.0	0.951006868914776	11	O95881	1
+Profilin conserved site [IPR027310]	0.4295081967213119	0.1299051500160723	0.89664146969504	1.0	0.9559525196487428	2	P35080	1
+Vinculin, conserved site [IPR000633]	0.4013114754098333	0.0850156984043902	0.932248910371366	1.0	0.9807092349336444	2	P18206	1
+Zinc finger, PHD-type, conserved site [IPR019786]	0.357200679752507	0.0137581233601659	0.9890229520865672	1.0	1.0	15	Q14839,O94880,Q9Y2K7,Q12873,Q13263,Q96L73,Q9BTC0,Q9NRL2,Q92576	9
+Cullin, conserved site [IPR016157]	0.3144076140465979	0.0062048208016031	0.9950493010466936	1.0	1.0	5	Q13616,Q13620,Q13617,Q13618	4
+DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]	0.3460844551744041	0.0053802715288717	0.9957071851251116	1.0	1.0	16	Q08211,O60231,Q12873,Q92620,O43143,Q9H2U1,Q14562	7

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site [IPR020611]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site [IPR014783]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GPCR, family 2, secretin-like, conserved site [IPR017983]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubby, C-terminal, conserved site [IPR018066]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADGRE5", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATP5C1", "ATP5O", "ATP7A", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCS1L", "BDH2", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAP2", "CAPZA1", "CAPZA2", "CAPZB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC40", "CDH2", "CDKAL1", "CDYL", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCP2", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DTYMK", "DYNLL1", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "ITGAV", "IVD", "KDM2A", "KDSR", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPST", "MRC2", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NID1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PAM", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHGDH", "PHIP", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "REL", "RNF14", "RNF2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLC2A4", "SLC4A2", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SORL1", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL1XR1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TULP3", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VLDLR", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ARIH2", "BAZ1A", "BPNT1", "CANX", "CDC40", "CECR2", "CHD3", "CHD4", "COPA", "CORO1C", "CUL1", "CUL2", "CUL3", "CUL4B", "DHCR7", "DHX15", "DHX16", "DHX36", "DHX38", "DHX8", "DHX9", "DIDO1", "DSC1", "DSC3", "EED", "EEF1D", "EIF3I", "GAA", "GEMIN5", "GMPPB", "HMOX1", "IDH2", "KDM2A", "LRWD1", "MPP6", "MRPS5", "MTOR", "NSD1", "NUP37", "PAFAH1B1", "PFKL", "PFN2", "PHF14", "PHF3", "PI4KB", "PLOD3", "PLRG1", "PNP", "PRKAR1A", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PYGB", "RACK1", "RAE1", "RPL3", "RPL7", "SERPINB8", "SNRNP40", "STRN", "TOP2A", "TRIM21", "TRIM28", "TXNDC12", "UTP18", "VCL", "WDHD1", "WDR12", "WDR18", "WDR41", "WDR5", "WDR61", "WDR77"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "1": "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "2": "Aminoacyl-tRNA synthetase, class II [IPR006195]", "3": "Double-stranded RNA-binding domain [IPR014720]", "4": "TGS [IPR004095]", "5": "GTP binding domain [IPR006073]", "6": "RNA recognition motif domain [IPR000504]", "7": "Helicase-associated domain [IPR007502]", "8": "Domain of unknown function DUF1605 [IPR011709]", "9": "von Willebrand factor, type A [IPR002035]", "10": "Immunoglobulin-like domain [IPR007110]", "11": "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "12": "Helicase, C-terminal [IPR001650]", "13": "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "14": "Zinc finger, PHD-type [IPR001965]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:68abc6174e7f74ed786c1ca829e8b6f8df31df84793d3c599df38d8cfec9b846
+size 160779

interpro_domain/df_merge.tsv

@@ -0,0 +1,5 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_50	pval_100	pval_250	pval_500
+Biotin carboxylase-like, N-terminal domain [IPR005481]	4	5	2.1060569113621503	0.0351994090855258	4.461165048543689	4.890776699029126	-1.9512728700118385	0.0878866289004478	0.922189565175296	0.311919174620445	1.421470494110228	0.2050995660155357	1.0	1.0	5.9744245214221845e-09	2.314587677291905e-07
+Biotin carboxylase, C-terminal [IPR005482]	4	5	2.1060569113621503	0.0351994090855258	4.461165048543689	4.890776699029126	-1.9512728700118385	0.0878866289004478	0.922189565175296	0.311919174620445	1.421470494110228	0.2050995660155357	1.0	1.0	5.9744245214221845e-09	2.314587677291905e-07
+Biotin carboxylation domain [IPR011764]	4	5	2.1060569113621503	0.0351994090855258	4.461165048543689	4.890776699029126	-1.9512728700118385	0.0878866289004478	0.922189565175296	0.311919174620445	1.421470494110228	0.2050995660155357	1.0	1.0	5.9744245214221845e-09	2.314587677291905e-07
+Isopropylmalate dehydrogenase-like domain [IPR024084]	1	5	1.9764218625488497	0.0481070174450719	1.8349514563106797	4.495145631067961	-0.0268416016144192	0.3268992301433215	1.18113888908689	0.4999764345469411	1.4254920509394828	0.309635855483207	0.0001415387755307	0.0006757625701886	0.0049685652699959	0.0202763085379925

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3052,
+    "annotations_size": 2546,
+    "title": "Average number of proteins per term",
+    "value": 2.1661429693637078
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C309/C309_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,250 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase C1A, papain C-terminal [IPR000668]	0.9839344262295074	2.186964571842265	0.0287451104034481	1.0	0.4541261177823215	2	P07858	1
+Biotin carboxylase-like, N-terminal domain [IPR005481]	0.9629143419757134	2.1060569113621503	0.0351994090855258	1.0	0.4541261177823215	5	Q96RQ3,O00763,P05165,P11498	4
+Biotin carboxylase, C-terminal [IPR005482]	0.9629143419757134	2.1060569113621503	0.0351994090855258	1.0	0.4541261177823215	5	Q96RQ3,O00763,P05165,P11498	4
+Biotin carboxylation domain [IPR011764]	0.9629143419757134	2.1060569113621503	0.0351994090855258	1.0	0.4541261177823215	5	Q96RQ3,O00763,P05165,P11498	4
+Acetyl-CoA carboxylase, central domain [IPR013537]	0.9619672131147542	2.099052012484214	0.0358123159751162	1.0	0.4541261177823215	2	O00763	1
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.9312327204663764	1.97642186254885	0.0481070174450719	1.0	0.4541261177823215	5	P48735	1
+Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]	0.9258458371126926	1.955577674401911	0.0505149249929905	1.0	0.4541261177823215	6	Q96RQ3,O00763,P05165,P11498	4
+Zinc finger, MYND-type [IPR002893]	0.9149582204083644	1.908480033064006	0.0563292014390441	1.0	0.4541261177823215	3	Q9H7B4	1
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.9106732348111636	1.897323570636759	0.0577852459592187	1.0	0.4541261177823215	7	P25786,O14818,P25787,P25789,P60900,P25788	6
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.9113446245826502	1.893670899197301	0.0582687062994384	1.0	0.4541261177823215	3	P48147	1
+Serpin domain [IPR023796]	0.9073017607643736	1.8771824221377855	0.0604930958488942	1.0	0.4541261177823215	4	P50452	1
+PB1 domain [IPR000270]	0.9047748436882906	1.8667071827269317	0.0619424901502367	1.0	0.4541261177823215	3	Q14596	1
+Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]	0.8809672674962494	1.7682037820977552	0.0770268421573532	1.0	0.4541261177823215	4	O00763	1
+Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]	0.8809672674962494	1.7682037820977552	0.0770268421573532	1.0	0.4541261177823215	4	O00763	1
+Acetyl-CoA carboxylase [IPR034733]	0.8809672674962494	1.7682037820977552	0.0770268421573532	1.0	0.4541261177823215	4	O00763	1
+L27 domain [IPR004172]	0.8727868852459026	1.7357648039723648	0.0826054297356377	1.0	0.4541261177823215	2	Q9NZW5	1
+L27 domain, C-terminal [IPR014775]	0.8727868852459026	1.7357648039723648	0.0826054297356377	1.0	0.4541261177823215	2	Q9NZW5	1
+ERAP1-like C-terminal domain [IPR024571]	0.8661856346342984	1.7073723334791642	0.0877528693202003	1.0	0.4541261177823215	3	Q9NZ08,Q9UIQ6	2
+Nucleoside phosphorylase domain [IPR000845]	0.8649180327868718	1.7032821266000402	0.0885152837859806	1.0	0.4541261177823215	2	P00491	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.8572523658843296	1.6690216167117968	0.0951130958561627	1.0	0.4603763156840122	6	Q14914,Q8N4Q0	2
+Radical SAM [IPR007197]	0.8527868852459047	1.6530949244177169	0.0983115461602599	1.0	0.4617683778632245	2	Q9H9T3	1
+Elp3/MiaB/NifB [IPR006638]	0.8527868852459047	1.6530949244177169	0.0983115461602599	1.0	0.4617683778632245	2	Q9H9T3	1
+CARG-binding factor, N-terminal [IPR012956]	0.8455737704918054	1.6231957169394604	0.1045475731541505	1.0	0.4626861395200475	2	Q14103	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.8389635946211816	1.594128981951577	0.1109071488106145	1.0	0.4651887988003702	3	Q9BUJ2,Q1KMD3	2
+Zinc finger, CHHC-type [IPR012996]	0.8379796654640767	1.5900251790106603	0.1118291295917097	1.0	0.4659852110319035	3	P31943,P55795	2
+Histone deacetylase domain [IPR023801]	0.8367213114754088	1.586447639071499	0.1126378010200559	1.0	0.4673855302997138	2	Q13547	1
+Immunoglobulin I-set [IPR013098]	0.804310573749604	1.447491621308142	0.147759281424624	1.0	0.4911040285392399	4	Q8WX93,Q96J84	2
+Biotin/lipoyl attachment [IPR000089]	0.8031820226393578	1.4456907662115397	0.1482639554057243	1.0	0.4911040285392399	8	Q96RQ3,O00763,P05165,P11498	4
+U-box domain [IPR003613]	0.8024712682942662	1.437283709769382	0.1506373956888191	1.0	0.4911040285392399	6	P19474	1
+Zinc finger, MYM-type [IPR010507]	0.7960655737704911	1.4171112579134966	0.1564504015836201	1.0	0.4975876133928487	2	Q9UBW7	1
+Protein of unknown function DUF3504 [IPR021893]	0.7963266644801472	1.415822174771377	0.1568275754404693	1.0	0.4975876133928487	3	Q2TAL8,Q9UBW7	2
+Zinc finger, ZZ-type [IPR000433]	0.7966166920894378	1.4151256486303372	0.1570316592610814	1.0	0.4975876133928487	4	Q14596	1
+START domain [IPR002913]	0.7924590163934424	1.4020607893745856	0.1608970947260759	1.0	0.4979794938572932	2	Q9NQZ5	1
+Pumilio homology domain [IPR033133]	0.7911475409836045	1.3965873707298115	0.1625376902574276	1.0	0.4979794938572932	2	Q14671	1
+Rap/Ran-GAP domain [IPR000331]	0.787868852459015	1.3829029063009637	0.1666946390659864	1.0	0.5004622283133002	2	Q86X10	1
+Glutaredoxin [IPR002109]	0.7875500611541597	1.3769720140948578	0.1685209004792629	1.0	0.5004622283133002	4	P35754	1
+Bromo adjacent homology (BAH) domain [IPR001025]	0.7834519270231912	1.3597247054963333	0.1739170570336639	1.0	0.5048970732110702	4	O94776,P26358	2
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.7772333284839819	1.3358056208135507	0.1816128153175427	1.0	0.5091031516442408	3	P52888	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.7769575053922306	1.330464978383339	0.1833651178545832	1.0	0.5091031516442408	5	P55786,Q9NZ08,Q9UIQ6	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.7769575053922306	1.330464978383339	0.1833651178545832	1.0	0.5091031516442408	5	P55786,Q9NZ08,Q9UIQ6	3
+TRASH domain [IPR011017]	0.7703991622313431	1.3071685579259391	0.1911554714556647	1.0	0.5148924237882742	3	Q9UBW7	1
+Nucleotidyl transferase domain [IPR005835]	0.7674647425385304	1.2948754070210653	0.1953632135307903	1.0	0.5217867655650409	3	Q96IJ6,Q9Y5P6	2
+PIK-related kinase, FAT [IPR003151]	0.7664808133814206	1.290753948021251	0.1967890112416159	1.0	0.5229904202726036	3	P78527,P42345	2
+FATC domain [IPR003152]	0.7664808133814206	1.290753948021251	0.1967890112416159	1.0	0.5229904202726036	3	P78527,P42345	2
+PIK-related kinase [IPR014009]	0.7664808133814206	1.290753948021251	0.1967890112416159	1.0	0.5229904202726036	3	P78527,P42345	2
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7629508196721211	1.2789119953924577	0.2009280480307524	1.0	0.5257582839530276	2	O60506	1
+NAD(P)-binding domain [IPR016040]	0.7625500715968616	1.2742919735515303	0.2025599600194136	1.0	0.5268309155936439	3	P30043	1
+LEM-like domain [IPR013146]	0.7616393442622721	1.2734421490848589	0.2028611887382669	1.0	0.5268309155936439	2	P42166	1
+MHC class I-like antigen recognition-like [IPR011161]	0.762645735102819	1.272190766719046	0.2033053474386921	1.0	0.5268309155936439	4	Q9UNN8	1
+TRIAD supradomain [IPR044066]	0.746313427572304	1.20636630333041	0.2276762827785248	1.0	0.5538470873565502	3	O95376	1
+IBR domain [IPR002867]	0.746313427572304	1.20636630333041	0.2276762827785248	1.0	0.5538470873565502	3	O95376	1
+Coatomer, WD associated region [IPR006692]	0.7340983606557359	1.1587871868030428	0.246542941623139	1.0	0.5735645314924752	2	P35606	1
+Ubiquitin system component CUE [IPR003892]	0.7354094816253243	1.1578932782452531	0.2469075909331315	1.0	0.5735645314924752	4	Q9H0E2	1
+Zinc finger, CXXC-type [IPR002857]	0.732692070937222	1.149520491833343	0.2503414219751747	1.0	0.5780948336739105	3	Q9Y2K7	1
+Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]	0.7222950819672151	1.1098411020304455	0.2670675042528301	1.0	0.6006659592117539	2	Q9H4A4	1
+Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]	0.7186885245901629	1.0949177074827368	0.2735526906105217	1.0	0.6035226605670608	2	P00387	1
+FAD-binding domain, ferredoxin reductase-type [IPR017927]	0.7186885245901629	1.0949177074827368	0.2735526906105217	1.0	0.6035226605670608	2	P00387	1
+Oxidoreductase FAD/NAD(P)-binding [IPR001433]	0.7186885245901629	1.0949177074827368	0.2735526906105217	1.0	0.6035226605670608	2	P00387	1
+Domain of unknown function DUF1087 [IPR009463]	0.7157377049180312	1.0827204544645466	0.2789325221739931	1.0	0.608680601907761	2	Q12873	1
+CHD, C-terminal 2 [IPR012957]	0.7157377049180312	1.0827204544645466	0.2789325221739931	1.0	0.608680601907761	2	Q12873	1
+CHD subfamily II, SANT-like domain [IPR009462]	0.7157377049180312	1.0827204544645466	0.2789325221739931	1.0	0.608680601907761	2	Q12873	1
+CHD, N-terminal [IPR012958]	0.7157377049180312	1.0827204544645466	0.2789325221739931	1.0	0.608680601907761	2	Q12873	1
+Brix domain [IPR007109]	0.7143560693941065	1.0700204992647608	0.2846100816866723	1.0	0.6097435744641779	4	Q9H7B2,Q9H9Y2	2
+ATP-grasp fold [IPR011761]	0.7116992336466841	1.0562946160549669	0.2908336349619032	1.0	0.611027088092375	9	Q96RQ3,O00763,P05165,P11498	4
+RNA-binding S4 domain [IPR002942]	0.6996721311475438	1.0165471499527747	0.3093689066855931	1.0	0.626656618802446	2	P62701	1
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.6962554529420877	0.9917450425888596	0.3213219126575639	1.0	0.6323407616866414	5	Q8N4Q0	1
+CCAAT-binding factor [IPR005612]	0.6941446216369741	0.9898910665050356	0.3222273664828385	1.0	0.6323407616866414	3	Q9BVI4	1
+FAD/NAD(P)-binding domain [IPR023753]	0.694498657027402	0.984471816601991	0.3248835821505549	1.0	0.6323407616866414	5	P09622,O95831	2
+Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]	0.6901639344262334	0.977603655631585	0.3282703886240665	1.0	0.6323407616866414	2	P18124	1
+Ribosomal protein L7, eukaryotic/archaeal [IPR035808]	0.6901639344262334	0.977603655631585	0.3282703886240665	1.0	0.6323407616866414	2	P18124	1
+Ribosomal protein L30, N-terminal [IPR012988]	0.6901639344262334	0.977603655631585	0.3282703886240665	1.0	0.6323407616866414	2	P18124	1
+FAD dependent oxidoreductase [IPR006076]	0.6906409561061737	0.9755108937314872	0.3293069006553368	1.0	0.6323407616866414	3	Q8NCN5	1
+SKP1 component, POZ domain [IPR016073]	0.688524590163937	0.9709084040569168	0.3315938928017672	1.0	0.6323407616866414	2	P63208	1
+Spt5 C-terminal domain [IPR024945]	0.6875409836065571	0.966894127371533	0.3335969627002699	1.0	0.6343075930058905	2	Q9UQ35	1
+Nucleoside diphosphate kinase-like domain [IPR034907]	0.685470646113476	0.9543405452655794	0.3399112908371715	1.0	0.6432866621486116	3	Q13232,P15531	2
+DZF domain [IPR006561]	0.6838251411589125	0.9438813673416095	0.3452302745556321	1.0	0.6434828433545908	4	Q12906,Q96KR1	2
+Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]	0.6806713324525288	0.9347466058096509	0.3499189022637283	1.0	0.6468156685653487	3	P09622	1
+ARHGEF1-like, PH domain [IPR041020]	0.6779856618499898	0.9238075270325208	0.3555865355487655	1.0	0.6495032422611244	3	Q92974	1
+Dbl homology (DH) domain [IPR000219]	0.6779856618499898	0.9238075270325208	0.3555865355487655	1.0	0.6495032422611244	3	Q92974	1
+SH2 domain [IPR000980]	0.6800583667812903	0.9228563085945646	0.3560820920894718	1.0	0.6495032422611244	9	P62993,P16333	2
+Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]	0.6774995923388505	0.918008788301166	0.3586142649039407	1.0	0.6508740987240016	4	O43776	1
+OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]	0.6748265495430976	0.9035361583167596	0.3662414068095576	1.0	0.652288569201499	5	O43776	1
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.6672131147540978	0.8844728943080026	0.3764409883459396	1.0	0.6582546403356884	2	P08236	1
+Suppressor of forked [IPR008847]	0.664262295081967	0.8726043788685196	0.3828787529757533	1.0	0.664039036155496	2	Q12996	1
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.6667083046081561	0.8704484296008428	0.3840553902306864	1.0	0.6643066011344204	5	P42694,Q9HCE1,O60306	3
+Class I myosin tail homology domain [IPR010926]	0.6634325801298824	0.8648845424447714	0.3871021624937603	1.0	0.6650953090777145	3	O43795	1
+Class I myosin, motor domain [IPR036072]	0.6634325801298824	0.8648845424447714	0.3871021624937603	1.0	0.6650953090777145	3	O43795	1
+Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]	0.6630206406002719	0.8592175140923831	0.3902205224114565	1.0	0.6670849915238675	4	P32119	1
+Peroxiredoxin, C-terminal [IPR019479]	0.6630206406002719	0.8592175140923831	0.3902205224114565	1.0	0.6670849915238675	4	P32119	1
+GUCT [IPR012562]	0.6606557377049179	0.8581354864814736	0.3908176542630515	1.0	0.6670849915238675	2	Q9NR30	1
+Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]	0.6608286729093197	0.8428073472141703	0.3993361982280099	1.0	0.6718841250184593	7	O75717,Q12834,P53621,Q96J01,Q8TEQ6	5
+DNA2/NAM7 helicase, helicase domain [IPR041677]	0.6579913843039356	0.8389531660003793	0.4014955914179179	1.0	0.6738350532300719	4	O60306,P42694	2
+Zinc finger, UBR-type [IPR003126]	0.6518032786885141	0.8228053723714541	0.4106186810864209	1.0	0.6823989308394437	2	Q5T4S7	1
+Glycoside hydrolase family 31, N-terminal domain [IPR025887]	0.6465573770491777	0.8020018990412262	0.4225518597357496	1.0	0.6887433001838786	2	P10253	1
+Bms1/Tsr1-type G domain [IPR030387]	0.6396721311475386	0.7748602501914472	0.4384222426025728	1.0	0.6980932213061404	2	Q2NL82	1
+AARP2CN [IPR012948]	0.6396721311475386	0.7748602501914472	0.4384222426025728	1.0	0.6980932213061404	2	Q2NL82	1
+Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]	0.6396721311475386	0.7748602501914472	0.4384222426025728	1.0	0.6980932213061404	2	Q2NL82	1
+Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]	0.643503309566194	0.7735310013415981	0.4392081889041601	1.0	0.6980932213061404	6	P42345,Q9UBF8	2
+TOPRIM  domain [IPR006171]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+DNA topoisomerase 2, TOPRIM domain [IPR034157]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+C-terminal associated domain of TOPRIM [IPR031660]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+DTHCT [IPR012542]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+DNA topoisomerase, type IIA,  domain A [IPR002205]	0.632786885245903	0.7479173100439738	0.4545100358265266	1.0	0.7057019885850069	2	P11388	1
+WSTF/Acf1/Cbp146 [IPR013136]	0.6236065573770415	0.7123294910998823	0.4762607660898765	1.0	0.7103455831662716	2	Q9NRL2	1
+NOP5, N-terminal [IPR012974]	0.6226229508196737	0.7085407002463333	0.4786095466214224	1.0	0.7124346748463847	2	O00567	1
+CID domain [IPR006569]	0.6255441990298953	0.702652436130829	0.4822723759904921	1.0	0.7139835709689664	6	O95104	1
+Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]	0.621843227287632	0.700736820841996	0.4834672727221123	1.0	0.7139835709689664	3	Q15393,Q10570	2
+Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]	0.621843227287632	0.700736820841996	0.4834672727221123	1.0	0.7139835709689664	3	Q15393,Q10570	2
+Phospholipid/glycerol acyltransferase [IPR002123]	0.6207829525148852	0.6966538727712541	0.4860194325496443	1.0	0.7152632805036963	3	O15228	1
+Ribosomal protein S5, N-terminal [IPR013810]	0.618360655737693	0.6921794520048508	0.4888246410576	1.0	0.7156685084144047	2	P82675	1
+Ribosomal protein S5, C-terminal [IPR005324]	0.618360655737693	0.6921794520048508	0.4888246410576	1.0	0.7156685084144047	2	P82675	1
+IPT domain [IPR002909]	0.6090873145060358	0.6520200479938013	0.5143882394364385	1.0	0.7294525348542962	3	Q04864	1
+OTU domain [IPR003323]	0.6083961954739137	0.6494067816485002	0.5160754817370741	1.0	0.730365856866365	3	Q01804,Q6GQQ9	2
+Cadherin, cytoplasmic domain [IPR000233]	0.6037055516802277	0.6271503674720915	0.5305606738161561	1.0	0.7389537612340993	4	Q08554,Q14574	2
+Cadherin prodomain [IPR014868]	0.6037055516802277	0.6271503674720915	0.5305606738161561	1.0	0.7389537612340993	4	Q08554,Q14574	2
+Sec24-like, trunk domain [IPR041742]	0.5982289275172066	0.611297990848263	0.5410023208646959	1.0	0.743330765742858	3	O95487,P53992	2
+Sec23/Sec24, helical domain [IPR006900]	0.5984251968503997	0.6073971065289044	0.5435874082371497	1.0	0.7438232549687944	4	O95487,Q15436,P53992	3
+Sec23/Sec24, trunk domain [IPR006896]	0.5984251968503997	0.6073971065289044	0.5435874082371497	1.0	0.7438232549687944	4	O95487,Q15436,P53992	3
+Sec23/Sec24 beta-sandwich [IPR012990]	0.5984251968503997	0.6073971065289044	0.5435874082371497	1.0	0.7438232549687944	4	O95487,Q15436,P53992	3
+Zinc finger, Sec23/Sec24-type [IPR006895]	0.5984251968503997	0.6073971065289044	0.5435874082371497	1.0	0.7438232549687944	4	O95487,Q15436,P53992	3
+cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]	0.59311475409836	0.597367939334515	0.5502617540386048	1.0	0.7453580292477379	2	P10644	1
+Gelsolin-like domain [IPR007123]	0.5930240062751997	0.582958944247112	0.559920938650684	1.0	0.749505105049759	5	O95487,Q15436,P53992	3
+Ribosomal RNA methyltransferase FtsJ domain [IPR002877]	0.5889134131731862	0.5769691405881351	0.5639603022049122	1.0	0.7512179115079523	3	Q8IY81	1
+Phosphofructokinase domain [IPR000023]	0.5883578995216906	0.5749408354414138	0.5653313112526459	1.0	0.7512179115079523	3	P17858	1
+Copine, C-terminal [IPR010734]	0.5826229508196755	0.559162458413307	0.576050851685904	1.0	0.759566300070513	2	Q99829	1
+Copine, C2B domain [IPR037768]	0.5826229508196755	0.559162458413307	0.576050851685904	1.0	0.759566300070513	2	Q99829	1
+GNAT domain [IPR000182]	0.5847531450209195	0.5526573729508487	0.5804980475814754	1.0	0.7618008454592887	5	Q9H9T3,Q86UY6	2
+Extended PHD (ePHD) domain [IPR034732]	0.5808484203789999	0.5477407206385002	0.583869947380407	1.0	0.762715693191645	3	O94880	1
+SNF2, N-terminal [IPR000330]	0.5800294955107341	0.5255947680518662	0.5991697926656692	1.0	0.7708827577179318	13	P28370,O14646	2
+Aminotransferase, class I/classII [IPR004839]	0.5746851657758146	0.5122663476984889	0.6084646140137906	1.0	0.7765167455033136	6	P17174,Q6YP21	2
+Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]	0.574430988447237	0.5113620998598565	0.609097528425844	1.0	0.7769350237335665	6	Q9NVN8,Q8NC60	2
+Vicinal oxygen chelate (VOC) domain [IPR037523]	0.5685245901639384	0.5091020932173795	0.6106806646730811	1.0	0.7776901806126003	2	Q04760	1
+Aminopeptidase P, N-terminal [IPR007865]	0.5681967213114782	0.507956561821732	0.6114838066268993	1.0	0.7776901806126003	2	P12955	1
+Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]	0.568567676369369	0.50418752987544	0.6141296025590384	1.0	0.77828470289463	3	O60568	1
+Fxr1, tudor domain [IPR041560]	0.5653259777108276	0.4928955479029375	0.6220863932249228	1.0	0.7798286347369047	3	P51114	1
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.5653259777108276	0.4928955479029375	0.6220863932249228	1.0	0.7798286347369047	3	P51114	1
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.5653259777108276	0.4928955479029375	0.6220863932249228	1.0	0.7798286347369047	3	P51114	1
+Agenet-like domain [IPR008395]	0.5653259777108276	0.4928955479029375	0.6220863932249228	1.0	0.7798286347369047	3	P51114	1
+Core histone macro-H2A, macro domain [IPR035796]	0.5626229508196754	0.4886192930566808	0.625111251492394	1.0	0.7805459766060004	2	Q9P0M6	1
+Transketolase, C-terminal domain [IPR033248]	0.5622950819672095	0.4874899808396412	0.6259111413270155	1.0	0.7807789151487416	2	P11177	1
+Transcription elongation factor S-II, central domain [IPR003618]	0.5503181718785436	0.4418218610249726	0.6586181179289023	1.0	0.8033229294387748	3	Q92576	1
+FCH domain [IPR001060]	0.547213114754102	0.4365761509140468	0.6624187616755148	1.0	0.8046365301650099	2	Q9UKS6	1
+F-BAR domain [IPR031160]	0.547213114754102	0.4365761509140468	0.6624187616755148	1.0	0.8046365301650099	2	Q9UKS6	1
+C2 domain [IPR000008]	0.5531362240752622	0.4289150859771737	0.6679850211204494	1.0	0.8082006763107983	13	Q96PU5	1
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.5442622950819723	0.4268622471577951	0.6694796647052135	1.0	0.8082006763107983	2	P29692	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.5442622950819723	0.4268622471577951	0.6694796647052135	1.0	0.8082006763107983	2	P29692	1
+Anticodon-binding [IPR004154]	0.5431956078552662	0.4135463115089502	0.6792063992474942	1.0	0.8119053095376835	4	P07814	1
+RII binding domain [IPR018459]	0.5383606557377103	0.4076910991834522	0.6835004729333227	1.0	0.8142591119013335	2	Q12802	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.5363934426229552	0.4013785938341943	0.6881414071219616	1.0	0.8165494462040784	2	P51114	1
+RasGAP protein, C-terminal [IPR000593]	0.535737704918036	0.3992832383476843	0.6896845162490075	1.0	0.8165494462040784	2	Q13576	1
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.541205774300767	0.396027800165779	0.6920845197696888	1.0	0.8172760609154117	7	Q14914,Q8N4Q0	2
+Aminoacyl-tRNA synthetase, class II [IPR006195]	0.5399536804097406	0.3857445417267013	0.6996858715231862	1.0	0.8194113288399412	11	P07814,Q9BW92,Q6PI48,O43776,Q9NP81	5
+Ribosomal protein L18e/L15P [IPR021131]	0.5317413975705656	0.3815965492742609	0.7027606441715513	1.0	0.821500734646818	3	P46776	1
+Calponin homology domain [IPR001715]	0.5341775353512884	0.3695799684018101	0.7116954788420626	1.0	0.824937774711156	21	Q15149,Q15555	2
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.5086913742210405	0.3120666537185317	0.754989868377081	1.0	0.8434419503677263	3	O43823,Q9ULX6	2
+Translation initiation factor, beta propellor-like domain [IPR013979]	0.5002786226379343	0.2882631214709386	0.7731453343251826	1.0	0.8580767311211487	3	P55884	1
+Tudor domain [IPR002999]	0.5047037017423912	0.282832189139341	0.777305477980456	1.0	0.8610029263901934	8	Q14739	1
+Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]	0.5014706635198733	0.2826139419378617	0.7774727917403985	1.0	0.8610029263901934	5	Q08209	1
+DDT domain [IPR018501]	0.4968612074003399	0.2788480010857693	0.7803614753159591	1.0	0.8630757237855916	3	Q9NRL2	1
+WHIM2 domain [IPR028941]	0.4968612074003399	0.2788480010857693	0.7803614753159591	1.0	0.8630757237855916	3	Q9NRL2	1
+Zinc finger, CCHC-type [IPR001878]	0.50019584456732	0.2702500759866792	0.7869678703117831	1.0	0.8692495435200867	8	Q9NUD5,Q9BWF3	2
+JmjC domain [IPR003347]	0.4933846807737175	0.2694241989623846	0.7876032663343357	1.0	0.8695741179909882	3	Q9Y2K7	1
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.4940129945922766	0.2581585586285415	0.7962845395045406	1.0	0.8780166468508274	6	P07948,Q15375,Q05397	3
+Double-stranded RNA-binding domain [IPR014720]	0.4954402514471135	0.2490379983766668	0.8033313886988913	1.0	0.8838728243852105	13	P55265,Q96SI9,Q12906,Q08211,Q9NXV6,O15226,O75569	7
+Bromodomain [IPR001487]	0.4956850069954254	0.2472828868427783	0.8046893019283234	1.0	0.8846023155049704	16	Q9BXF3,Q9H0E9,Q9NRL2,Q9NPI1	4
+Cadherin-like [IPR002126]	0.4762158709865449	0.2167646074032894	0.828391795356108	1.0	0.9083055602827954	5	Q08554,Q14574	2
+Dehydrogenase, E1 component [IPR001017]	0.4672131147541071	0.2080843702319522	0.8351630908052712	1.0	0.9129777712280897	2	P08559	1
+PUA domain [IPR002478]	0.4697931217629746	0.2055113239450965	0.8371726516863998	1.0	0.9147817902118344	4	Q9ULC4	1
+Transketolase-like, pyrimidine-binding domain [IPR005475]	0.4673663496228037	0.2040437679388333	0.838319296444372	1.0	0.91497029712099	3	P29401,P11177	2
+G-patch domain [IPR000467]	0.4743284256799142	0.1933192035853459	0.8467089877113885	1.0	0.921642190129626	14	Q9UBB9,P52756	2
+S1 domain [IPR003029]	0.4661446929236736	0.1891333900523713	0.8499882722605474	1.0	0.924320616984026	6	P05198,P62487,Q14562	3
+RNA-binding domain, S1 [IPR022967]	0.4661446929236736	0.1891333900523713	0.8499882722605474	1.0	0.924320616984026	6	P05198,P62487,Q14562	3
+NUC153 [IPR012580]	0.4586885245901664	0.1886093513847367	0.850399003020178	1.0	0.924320616984026	2	Q9BSC4	1
+Thioesterase domain [IPR006683]	0.4577049180327897	0.186428915087608	0.8521084189260215	1.0	0.9251462834053948	2	O00154	1
+WHIM1 domain [IPR028942]	0.4560367454068433	0.1744912367522233	0.8614794171834084	1.0	0.932992110947836	4	Q9NRL2,Q9UIG0,Q96T23	3
+TGS [IPR004095]	0.4569927774130178	0.1689063786320816	0.8658702818665613	1.0	0.935301543331466	6	Q9Y295,Q9BW92,Q9NTK5,P55039,P26639	5
+Immunoglobulin subtype 2 [IPR003598]	0.4569963135736222	0.1600210640000466	0.8728644813587236	1.0	0.9417888225286364	10	P10586,Q8WX93,P35613,Q96J84	4
+Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]	0.4524838091456714	0.1593976115286821	0.8733556205774198	1.0	0.9417888225286364	6	Q9NP81,P07814	2
+SET domain [IPR001214]	0.4574774746409992	0.1575209601916793	0.8748342902542556	1.0	0.9427691483595296	12	Q9H7B4,Q9NRG4	2
+GTP binding domain [IPR006073]	0.4539462850319177	0.1500184520195676	0.8807500573989966	1.0	0.94815629857837	12	O75616,P36915,Q8NC60,Q9NTK5,Q9NVN8,Q9BZE4	6
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.4492960985642136	0.1440086798414659	0.8854936155620035	1.0	0.952055213353404	10	P07948,Q9UHY1,Q15375,Q05397	4
+ENTH  domain [IPR013809]	0.4331089646471151	0.1326393934389884	0.8944785761998935	1.0	0.9604987157338376	3	Q14677	1
+R3H domain [IPR001374]	0.4309609708100868	0.1287370200364302	0.8975657413812075	1.0	0.960661274657598	3	O15226,Q9H6S0	2
+Marvel domain [IPR008253]	0.4285245901639312	0.1281438643244022	0.8980351234617241	1.0	0.960661274657598	2	Q16625	1
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.4362340589919002	0.1276568527254091	0.8984205371709666	1.0	0.960661274657598	6	Q9NZW5	1
+Guanylate kinase-like domain [IPR008144]	0.4362340589919002	0.1276568527254091	0.8984205371709666	1.0	0.960661274657598	6	Q9NZW5	1
+Ribosomal protein S7 domain [IPR023798]	0.424262295081964	0.1206759683635203	0.9039476943317092	1.0	0.965293611388606	2	Q9Y2R9	1
+BRO1 domain [IPR004328]	0.4206557377049196	0.1145652509914854	0.9087897239957088	1.0	0.9689190273421584	2	Q5VW32	1
+Protein phosphatase 1 binding domain [IPR029334]	0.4193442622950802	0.1123904022162749	0.9105138650341404	1.0	0.9699448955551974	2	P46013	1
+SPRY domain [IPR003877]	0.428506450785193	0.1035141123909042	0.9175549495937788	1.0	0.9755964303231728	11	Q9BUJ2,P19474,Q1KMD3	3
+B30.2/SPRY domain [IPR001870]	0.428506450785193	0.1035141123909042	0.9175549495937788	1.0	0.9755964303231728	11	Q9BUJ2,P19474,Q1KMD3	3
+Peptidase M16, middle/third domain [IPR032632]	0.4081967213114747	0.094915037744058	0.924382312052658	1.0	0.9818428729603952	2	P14735	1
+Zinc finger, RanBP2-type [IPR001876]	0.420496527313971	0.0942076967398005	0.9249441708544166	1.0	0.9820299662199102	9	P35637,P52756	2
+KOW [IPR005824]	0.4094477555333433	0.0869951617900441	0.9306753578605856	1.0	0.986880242029592	5	P62701,Q92917	2
+Aminoacyl-tRNA synthetase, class Ia [IPR002300]	0.4067915403347221	0.0831956302221943	0.93369598727336	1.0	0.9877923073627352	5	Q15031	1
+Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]	0.4067915403347221	0.0831956302221943	0.93369598727336	1.0	0.9877923073627352	5	Q15031	1
+FCP1 homology domain [IPR004274]	0.3986885245901601	0.0814215715783684	0.935106694425426	1.0	0.9881232572578318	2	Q05D32	1
+RNA recognition motif domain [IPR000504]	0.2180674417662911	0.0743016282529344	0.9407703814564334	1.0	0.9922126724059982	111	Q15424,P55795,P84103,O60506,P31942,O14979,O95104,P22626,P31943,Q9BYG3,P14866,Q96PK6,Q96EP5,P52756,Q99729,Q9BWF3,Q8IY67,P35637,Q13148,Q14103,P51991,Q92804	22
+Helicase-associated domain [IPR007502]	0.4097613908433994	0.0710822981937118	0.9433322565244072	1.0	0.9936279029646125	13	Q08211,O60231,Q92620,Q9H2U1,O43143	5
+Domain of unknown function DUF1605 [IPR011709]	0.4097613908433994	0.0710822981937118	0.9433322565244072	1.0	0.9936279029646125	13	Q08211,O60231,Q92620,Q9H2U1,O43143	5
+Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]	0.3881967213114761	0.0680039138319821	0.9457825187117987	1.0	0.9946147429327716	2	P32322	1
+Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]	0.3881967213114761	0.0680039138319821	0.9457825187117987	1.0	0.9946147429327716	2	P32322	1
+NOSIC [IPR012976]	0.387668087897662	0.0644068263825771	0.948646294647382	1.0	0.9955702663529408	3	Q9Y2X3,O00567	2
+Nop domain [IPR002687]	0.387668087897662	0.0644068263825771	0.948646294647382	1.0	0.9955702663529408	3	Q9Y2X3,O00567	2
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.3863561823548665	0.062870146312683	0.9498699075909016	1.0	0.9964436690261372	3	Q7L576,Q9NUQ9	2
+Peptidase M16, C-terminal [IPR007863]	0.3917524260058166	0.0587946507146812	0.9531156692031572	1.0	0.9973828581139492	7	P14735,P31930	2
+Peptidase M16, N-terminal [IPR011765]	0.3917524260058166	0.0587946507146812	0.9531156692031572	1.0	0.9973828581139492	7	P14735,P31930	2
+Longin domain [IPR010908]	0.3801246310265601	0.0558846633860073	0.9554336885803144	1.0	0.99881788691508	3	O75396,P51809	2
+v-SNARE, coiled-coil homology domain [IPR042855]	0.3801246310265601	0.0558846633860073	0.9554336885803144	1.0	0.99881788691508	3	O75396,P51809	2
+von Willebrand factor, type A [IPR002035]	0.377872619829285	0.0457150015294499	0.9635374068188198	1.0	1.0	6	Q99829,Q9NU22,Q96SY0,P13010,O75131	5
+Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]	0.3671259842519656	0.0404450464879552	0.9677383177055848	1.0	1.0	4	P15170,P49411,Q05639	3
+RNA polymerase Rpb1, domain 4 [IPR007083]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+RNA polymerase Rpb1, domain 5 [IPR007081]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+RNA polymerase, alpha subunit [IPR000722]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+RNA polymerase Rpb1, domain 3 [IPR007066]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+RNA polymerase Rpb1, domain 1 [IPR007080]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+RNA polymerase, N-terminal [IPR006592]	0.3631987160980741	0.0394262688161672	0.9685505367009128	1.0	1.0	3	O14802	1
+Immunoglobulin-like domain [IPR007110]	0.3873991004674427	0.0390152345502937	0.9688782424468276	1.0	1.0	16	P10586,Q96J84,P10321,Q8WX93,P35613	5
+Immunoglobulin subtype [IPR003599]	0.3802414755858652	0.0374543259573974	0.9701227571780706	1.0	1.0	12	P10586,Q8WX93,P35613,Q96J84	4
+Serine-threonine protein phosphatase, N-terminal [IPR031675]	0.3531147540983561	0.0335825607655094	0.973210028917314	1.0	1.0	2	P62136	1
+Glycosyl transferase, family 1 [IPR001296]	0.3586369602618094	0.0332495315107289	0.9734755995030476	1.0	1.0	4	Q9H553	1
+Lactate/malate dehydrogenase, C-terminal [IPR022383]	0.3582677165354334	0.0329556181533741	0.973709979982292	1.0	1.0	4	P00338,P40925,P40926	3
+Lactate/malate dehydrogenase, N-terminal [IPR001236]	0.3582677165354334	0.0329556181533741	0.973709979982292	1.0	1.0	4	P00338,P40925,P40926	3
+Rpn11/EIF3F, C-terminal [IPR024969]	0.3562992125984271	0.0314148624120219	0.9749386885107232	1.0	1.0	4	P51665,Q7L5N1,O00487	3
+CSN8/PSMD8/EIF3K [IPR033464]	0.3519186618563403	0.0303693756965457	0.9757724682390432	1.0	1.0	3	Q99627,Q9UBQ5	2
+NAD-dependent epimerase/dehydratase [IPR001509]	0.3416393442622909	0.0254644605962662	0.9796844956248458	1.0	1.0	2	Q16795	1
+Threonyl/alanyl tRNA synthetase, SAD [IPR012947]	0.3508368887430203	0.0252162740105316	0.979882456300428	1.0	1.0	5	Q5JTZ9,P49588,Q9BW92,P26639	4
+AP180 N-terminal homology (ANTH) domain [IPR011417]	0.3406557377049118	0.0248328819987284	0.9801882630978966	1.0	1.0	2	Q13492	1
+FF domain [IPR002713]	0.3403278688524548	0.0246245301741976	0.9803544529805388	1.0	1.0	2	O75400	1
+Proteasome component (PCI) domain [IPR000717]	0.3728702585761885	0.023484423899009	0.981263862987446	1.0	1.0	17	Q9UNS2	1
+60S ribosomal protein L10P, insertion domain [IPR040637]	0.3373770491803231	0.0227976730285852	0.9818116641976756	1.0	1.0	2	Q9UKD2	1
+Amidohydrolase-related [IPR006680]	0.3355631587297675	0.0177035217146233	0.9858753711669244	1.0	1.0	4	Q14195,Q9BPU6	2
+Helicase superfamily 1/2, ATP-binding domain [IPR014001]	0.3369370859819721	0.0149405384443897	0.9880796185240972	1.0	1.0	64	Q92620,P28370,Q9H2U1,Q9UJV9,O43143,Q9NVP1,Q08211,O14646,O00571,Q92841,Q6ZRS2,Q12873,Q8TDD1,Q9GZR7,Q9H4L7,Q9Y2R4,P19447,P17844,O60231,Q9NY93,Q14562	21
+Endonuclease/exonuclease/phosphatase [IPR005135]	0.3320087919901013	0.0139026850043156	0.988907619613646	1.0	1.0	5	Q9UNK9	1
+Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]	0.3460789405077323	0.0136844807391193	0.9890817048658296	1.0	1.0	10	Q10567	1
+Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]	0.3311854344635043	0.0116666670111332	0.990691557680018	1.0	1.0	6	Q10567	1
+Thioredoxin domain [IPR013766]	0.3675711355671629	0.0113943085397205	0.9909088538532138	1.0	1.0	24	P32119,O95881	2
+Helicase, C-terminal [IPR001650]	0.3318119838325397	0.0100909259201571	0.9919487426432764	1.0	1.0	65	Q92620,P28370,Q9H2U1,Q9UJV9,O43143,Q9NVP1,Q08211,O14646,O00571,Q92841,Q6ZRS2,Q12873,Q8TDD1,Q9GZR7,Q9H4L7,Q9Y2R4,P19447,P17844,O60231,Q9NY93,Q14562	21
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.3039344262295004	0.0074874198958987	0.9940259590837724	1.0	1.0	2	P31689	1
+Zinc finger, RING-type [IPR001841]	0.3604992131331739	0.0067684332342357	0.9945996128550854	1.0	1.0	23	O95376,P19474	2
+Cullin homology domain [IPR016158]	0.3144076140465979	0.0062048208016031	0.9950493010466936	1.0	1.0	5	Q13616,Q13620,Q13617,Q13618	4
+Cullin protein, neddylation domain [IPR019559]	0.3144076140465979	0.0062048208016031	0.9950493010466936	1.0	1.0	5	Q13616,Q13620,Q13617,Q13618	4
+Cullin, N-terminal [IPR001373]	0.3144076140465979	0.0062048208016031	0.9950493010466936	1.0	1.0	5	Q13616,Q13620,Q13617,Q13618	4
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.3200560992981103	0.0052793988276788	0.9957876687528028	1.0	1.0	7	Q32P28,P13674	2
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.3200560992981103	0.0052793988276788	0.9957876687528028	1.0	1.0	7	Q32P28,P13674	2
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.3226018396846347	0.0048761392944456	0.996109419158195	1.0	1.0	8	Q7L5N1,Q6P2Q9,O00303,P51665,O15372,Q92905,O00487	7
+Zinc finger, PHD-type [IPR001965]	0.3531659154854127	0.0048746805238642	0.9961105830748866	1.0	1.0	20	O94880,Q14839,Q9Y2K7,Q12873,Q96L73,Q96T88,Q9NRL2,Q8IWS0	8
+Protein-tyrosine phosphatase, catalytic [IPR003595]	0.3060975286734312	0.0018433248960904	0.9985292403577686	1.0	1.0	6	P10586	1