diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..884813dd16650df34831385d765007d0befa28c2 --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Serine/threonine-protein kinase, active site [IPR008271]"} \ No newline at end of file diff --git a/interpro_active_site/basic/plot_0.png b/interpro_active_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..814ee00cc354cbbae100b711d378c434a1bce182 --- /dev/null +++ b/interpro_active_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e39eb04dbed703b38906e4f0548c9bc3654f845c7dd2728593cf2c344cb54563 +size 153065 diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4aaa757cc953f1cc8b5b30c93e0af8fc877feae5 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b27b2b52bd74118e59eee30a1fc2c7e041a70246c434b15fd291ffc1aa32a936 +size 69432 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0f6e7a3b2726769f8c3b71610085a70937f36afb --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 53, + "title": "Average number of proteins per term", + "value": 2.792452830188679 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f0d69bdafc6884b71554a3120b510d3f79e9ceba --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6e1db0f17e8dc337ec243e32d5b030d9d92b36e1 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine/threonine-protein kinase, active site [IPR008271] 0.3289656317045565 0.6733700147947184 0.5007119200125492 1.0 0.8837165645361431 45 P17612,P78362,P24941,P48729,Q86UE8,P11802,Q05655,P50750,Q00535,Q96KB5,P31751,Q13555,P31749 13 +Nucleoside diphosphate kinase, active site [IPR023005] 0.4119312231343535 0.1083149391363728 0.913745872618294 1.0 1.0 3 P22392 1 +Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345] 0.3987508218277423 0.0274022107665016 0.9781389349753992 1.0 1.0 2 P18669 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b856039c2d8bdf4df7f9de44a56ef5325f181fb8 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ACVR1B", "ADSS", "AKT1", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CASP2", "CASP3", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EGFR", "EIF2AK2", "EPHA7", "FASN", "G6PD", "GAA", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K4", "MAPK1", "MAPK3", "MASTL", "MDH1", "MDH2", "MTMR2", "MTMR6", "NEK9", "NME1", "NME2", "NME3", "PAK2", "PBK", "PGAM1", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCD", "PRPF4B", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["AKT1", "AKT2", "CAMK2G", "CDK2", "CDK4", "CDK5", "CDK9", "CSNK1A1", "NME2", "PBK", "PGAM1", "PRKACA", "PRKCD", "SRPK2", "TLK2"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1c0dc834f5e790aabb2e32b3ee6fb397fabe2c0c --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Protein kinase, ATP binding site [IPR017441]", "1": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..4222f68ab74f2e6ea99a611b79e3e1bcfffb12eb --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8231110024c444daae35d1f8a01e3299120704b1f7e6200fc688524fb17ee49f +size 150197 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..d502f965474a856dd51c8aa46e0483fb138e2269 --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:18f9920bb734a76d9ad5008d9968bf21e47304a1237f65b546d7394fc3292862 +size 141017 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..68510cae7b2acef2328216f936bae7415b266996 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5ba7b788940c5d1029578fdd5456065401e42c6de3435003dc70e89c753d4909 +size 67643 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7e9b8dfab39e5d0a80557f6a1fa2f698daaf629c --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 4.612903225806452 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c4603e67e46e16aad2592f135422875585378e48 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f9a311b7a2973fc6a786a6de5afe3ec519f4fcc0 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Biotin-binding site [IPR001882] 0.9611842105263164 2.3645207902541356 0.0180534140257095 0.4315087296336584 0.5596558347969973 4 P11498,Q96RQ3,P05165 3 +IQ motif, EF-hand binding site [IPR000048] 0.4886623529242552 0.9044309372974474 0.3657669397222607 0.9999992591757824 0.9707549639738916 10 Q15386 1 +Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.916502301117689 0.8809492034935978 0.3783453142737589 0.9999996018694018 0.9707549639738916 2 P34897 1 +Protein kinase, ATP binding site [IPR017441] 0.321257372071323 0.7540276490051429 0.4508326196316536 0.9999999914720092 0.9707549639738916 47 P17612,Q05397,P78362,Q86UE8,P48729,P11802,P50750,P31751,Q13555 9 +Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.8376068376068355 0.6324296706206464 0.5271061510397062 0.999999999917268 0.9707549639738916 2 O15270 1 +EF-Hand 1, calcium-binding site [IPR018247] 0.3661585598185191 0.4869503377555963 0.6262935251444461 0.999999999999944 0.9707549639738916 35 P80303,Q9Y680,P41208,O43852,Q9NWM8,Q9BRK5,Q15293,Q14257,O95302,Q02818 10 +Beta tubulin, autoregulation binding site [IPR013838] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a521a8cf7d8cf4884d3dff27bde39b6d0736f0e1 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ACVR1B", "ADSS", "AKT1", "AKT2", "APEX1", "APOBEC3C", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CETN2", "CHEK1", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EGFR", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LRP2", "LYN", "MACF1", "MAP2K1", "MAP2K4", "MAP4K5", "MAPK1", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO9B", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKN1", "PKN2", "PLK1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "PTK2", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TBK1", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["AKT2", "CALU", "CAMK2G", "CDK4", "CDK9", "CETN2", "CSNK1A1", "FKBP14", "FKBP7", "FKBP9", "MCCC1", "NUCB1", "NUCB2", "PC", "PCCA", "PRKACA", "PTK2", "RCN1", "RCN2", "SDF4", "SHMT2", "SPTLC2", "SRPK2", "TLK2", "TUBB", "TUBB4A", "UBE3C"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..0a5a022ba043fc91431be9634a2876afe5ef9f90 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Zinc finger, RING-type, conserved site [IPR017907]", "1": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3bf765c7d287aa231903367cd8bcabd6ec23640d --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1f7a1ecf021017a230f2c79a5f35245dbe754549832c51bcd2e413d3b4b0341d +size 152158 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..1556f6ebe86f1035c7fc9ab4ebf43962174ee1ba --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2fd2cf88bf1ffc414840c8af3ba63677fe811f5781c58eb4d098ae24d0a91bfa +size 155339 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1ae970f524de881c01087462b364ee8c5cdc51c9 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cc7d5579251993aa251ff4b89424b86b1f52807a2e6ff9de94e6d1f61b20ad0a +size 82880 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1b9972e4354052161f4b193d5750bc97b3d30c4d --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome beta-type subunit, conserved site [IPR016050] 3 8 2.6021432998645224 0.0092643132696985 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.2998708524751297e-05 8.689945997441637e-05 5.179472170036692e-05 0.0007990853642419 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 2 5 2.116544630605237 0.0342985135785878 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 1.0 1.0 0.0001168236586544 0.0009539541807411 +Cadherin conserved site [IPR020894] 2 5 1.962289180934736 0.0497288260933528 1.555825242718447 3.0558252427184467 -0.2693089236279177 0.4378099575304214 1.0377767725547085 1.0517161419538543 1.2797396443463749 0.3315735399503712 1.0 1.0 1.0 0.3430049269426823 0.0494682330743412 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ff12209d4915bb2355886b201b466d4fcf077b69 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 277, + "title": "Average number of proteins per term", + "value": 2.6570397111913358 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b612bec91bf6512a0755170773efa788dbcc4a03 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ba51adb54012ca0acfd7111b961fef14f69e0401 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,31 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome beta-type subunit, conserved site [IPR016050] 0.8706258849154627 2.6021432998645224 0.0092643132696985 0.9240876440776052 0.3489116807835174 8 P28074,P28070,P49721 3 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.8597165656075 2.116544630605237 0.0342985135785878 0.9999366884033336 0.3489116807835174 5 P50213,P48735 2 +Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.8657337026239511 1.9872765754435793 0.0468917560289741 0.999998331229523 0.3510544978385359 4 Q9UBF8,P42345 2 +Cadherin conserved site [IPR020894] 0.8225026231610645 1.962289180934736 0.0497288260933528 0.999999269243272 0.3575012538119029 5 Q08554,Q14574 2 +DnaJ domain, conserved site [IPR018253] 0.6211373533678725 1.580152069390087 0.1140720453087698 0.9999999999999972 0.517999287713594 9 O60884,Q99543 2 +Sterol reductase, conserved site [IPR018083] 0.9697567389875102 1.0586724327384218 0.2897489867781651 1.0 0.7000818503564671 2 Q14739 1 +Zinc finger, RING-type, conserved site [IPR017907] 0.5034243501103698 0.9682203042377672 0.3329343565943705 1.0 0.7559247276773823 13 O95376,P22681,Q9UPN9,Q99496,P19474 5 +Kinesin motor domain, conserved site [IPR019821] 0.4998386209327945 0.9519501733848048 0.3411222521772008 1.0 0.7605759433369766 12 Q86Y91,Q96Q89,Q02241,Q9BW19 4 +Guanylate kinase, conserved site [IPR020590] 0.6038080442383876 0.9046907898642844 0.3656292217536203 1.0 0.7851108095019599 4 Q14168 1 +Ubiquitin specific protease, conserved site [IPR018200] 0.4643844052964052 0.7712826397088121 0.4405394200690862 1.0 0.8972751423465947 12 Q9UPU5,Q93008,Q96K76,Q96RU2 4 +DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.4490996174737692 0.6863574610119794 0.4924877224426345 1.0 0.913751881774551 16 O60231,Q12873,Q14562,Q92620,Q9H2U1,P18074 6 +Mini-chromosome maintenance, conserved site [IPR018525] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.913751881774551 6 P33991,P33993 2 +EGF-like calcium-binding, conserved site [IPR018097] 0.4451836099869378 0.5347451627203742 0.5928260872086564 1.0 0.9659578009223402 7 P48960 1 +Cullin, conserved site [IPR016157] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.9751385561592322 5 Q13616,Q13617,Q13618,Q13620 4 +Tubulin, conserved site [IPR017975] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326] 0.6584483892176172 0.2013574229152592 0.8404191049142333 1.0 1.0 2 P29692 1 +Actin, conserved site [IPR004001] 0.6173570019723837 0.1406889646920251 0.8881156632813079 1.0 1.0 2 P61163 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.6170282708744184 0.1402673534115228 0.8884487574826165 1.0 1.0 2 P04439 1 +Tr-type G domain, conserved site [IPR031157] 0.3300427772293606 0.0910588390010526 0.9274458384332952 1.0 1.0 5 Q96RP9,P49411,Q05639,P13639 4 +IMP dehydrogenase / GMP reductase, conserved site [IPR015875] 0.5588428665351666 0.0807702109593559 0.9356246988547784 1.0 1.0 2 P20839 1 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.3725748109174566 0.0681554696528951 0.9456618745699288 1.0 1.0 3 P26583,P09429 2 +Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.5335305719921 0.0634658723119335 0.9493955343867246 1.0 1.0 2 P15880 1 +RNA polymerase, beta subunit, conserved site [IPR007121] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +Aldo/keto reductase, conserved site [IPR018170] 0.5190664036817758 0.0555747906030647 0.955680547643103 1.0 1.0 2 P14550 1 +Ribosomal protein L7Ae conserved site [IPR004037] 0.5157790927021577 0.053966107190763 0.9569621674178308 1.0 1.0 2 P55769 1 +Phosphofructokinase, conserved site [IPR015912] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 1.0 3 P08237 1 +Fumarate lyase, conserved site [IPR020557] 0.4970414201183319 0.0459911079456646 0.963317337242958 1.0 1.0 2 P07954 1 +Inositol monophosphatase, conserved site [IPR020550] 0.2938856015779102 0.0250165001392838 0.9800418025193376 1.0 1.0 2 Q9NX62 1 +Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131] 0.2928994082840248 0.0250135707067461 0.9800441391371452 1.0 1.0 2 Q9NQW7 1 +Ribosomal protein L30, conserved site [IPR018038] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 1.0 2 P18124 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..69693adaaaa880602c1abb1b09e1a68c1d6a9812 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site [IPR020611]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site [IPR014783]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GPCR, family 2, secretin-like, conserved site [IPR017983]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubby, C-terminal, conserved site [IPR018066]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADGRE5", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATP5C1", "ATP5O", "ATP7A", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCS1L", "BDH2", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAP2", "CAPZA1", "CAPZA2", "CAPZB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC40", "CDH2", "CDKAL1", "CDYL", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCP2", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DTYMK", "DYNLL1", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "ITGAV", "IVD", "KDM2A", "KDSR", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPST", "MRC2", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NID1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PAM", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHGDH", "PHIP", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "RNF14", "RNF2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLC2A4", "SLC4A2", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SORL1", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL1XR1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TULP3", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VLDLR", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACTR1A", "ADGRE5", "AKR1A1", "ARIH2", "CBL", "CHD3", "CUL1", "CUL2", "CUL3", "CUL4B", "DHX16", "DHX36", "DHX38", "DHX8", "DNAJA2", "DNAJC2", "DSC1", "DSC3", "EEF1A2", "EEF1D", "EEF2", "ERCC2", "FH", "GFM1", "HLA-A", "HMGB1", "HMGB2", "IDH2", "IDH3A", "IMPAD1", "IMPDH1", "KIF18B", "KIF20B", "KIF23", "KIFC1", "LBR", "MCM4", 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2fd0d7324f1fbccbdcc941054e8923347033680dd5e513a96ab0226371a66af8 +size 142612 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..65982f1515651794268a6963026ddd184422a98f --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8f11a54bc36c3811e438f1bf7eebb1c80d742d10f8c1ab8aa4c224f5922b3182 +size 198850 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d58184f9ab1680509c84568d389b74f645e3a74e --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,12 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479] 4 6 2.5279462021014565 0.0114731930955589 4.555825242718447 5.890776699029126 -2.014668773126755 0.0893555876700455 0.9291869546245032 0.311919174620445 1.4520862177793892 0.2126509357606074 1.0 1.0 0.0017136679159695 1.2610959333897418e-07 4.308021018563364e-06 +Biotin carboxylation domain [IPR011764] 4 5 2.526141708765465 0.011532295341899 4.461165048543689 4.890776699029126 -1.9512728700118385 0.0878866289004478 0.922189565175296 0.311919174620445 1.421470494110228 0.2050995660155357 1.0 1.0 0.0008259172121234 6.237585047144392e-09 2.219739724720047e-07 +Biotin carboxylase-like, N-terminal domain [IPR005481] 4 5 2.526141708765465 0.011532295341899 4.461165048543689 4.890776699029126 -1.9512728700118385 0.0878866289004478 0.922189565175296 0.311919174620445 1.421470494110228 0.2050995660155357 1.0 1.0 0.0008259172121234 6.237585047144392e-09 2.219739724720047e-07 +Biotin carboxylase, C-terminal [IPR005482] 4 5 2.526141708765465 0.011532295341899 4.461165048543689 4.890776699029126 -1.9512728700118385 0.0878866289004478 0.922189565175296 0.311919174620445 1.421470494110228 0.2050995660155357 1.0 1.0 0.0008259172121234 6.237585047144392e-09 2.219739724720047e-07 +Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 3 6 2.157162752109961 0.0309929855734436 2.878640776699029 6.735436893203883 -0.1009242226376213 0.5398631989476717 1.7790119700005456 1.6967720791950751 0.9747821830158722 0.3245983921794569 1.0 1.0 1.0 0.31158693813953 0.0055335244720432 +Aminopeptidase N-like , N-terminal domain [IPR045357] 2 5 2.129841148385085 0.0331847302262424 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.000647621121882 0.0022711903824547 0.0006213832587155 0.004805053921831 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 2 5 2.129841148385085 0.0331847302262424 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.000647621121882 0.0022711903824547 0.0006213832587155 0.004805053921831 +Isopropylmalate dehydrogenase-like domain [IPR024084] 2 5 2.116544630605237 0.0342985135785878 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 1.0 1.0 0.0001168236586544 0.0009539541807411 +ATP-grasp fold [IPR011761] 4 9 2.1161428952600456 0.034332656208099 5.140776699029126 8.29611650485437 -2.0480605739045723 0.1039395658178638 1.3125929938912535 0.6268153953315737 1.4054966721848676 0.2346695780741176 1.0 1.0 0.0052264902137193 4.3261655979057245e-06 0.0001335078390794 +Biotin/lipoyl attachment [IPR000089] 5 8 2.108298690128759 0.0350051611914827 5.182038834951456 8.361650485436893 -2.130161056715037 0.0953326994482326 1.4807396860722422 0.6846338360686358 1.3497960821287889 0.2162773212056401 1.0 1.0 0.0036065315551905 1.4296411838151886e-06 1.8402314930668324e-06 +Cadherin-like [IPR002126] 2 5 1.962289180934736 0.0497288260933528 1.5898058252427183 3.1310679611650487 -0.2612861714701764 0.4372142450358497 1.076759324040342 1.1605597181786682 1.2840907797021492 0.3325457904266107 1.0 1.0 1.0 0.387474652503821 0.0727801444512915 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a7098a8f008acef14cac4fe37fd9da204d8ba880 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 2541, + "title": "Average number of proteins per term", + "value": 2.166469893742621 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..289d021b97747725db6a382bc513976aca122c0d --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a7389e8d472c3af1d3f914a4eee439866aecae09 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,262 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479] 0.9209490420121778 2.5279462021014565 0.0114731930955589 0.9999999999998156 0.3978585776883465 6 P11498,O00763,Q96RQ3,P05165 4 +Biotin carboxylation domain [IPR011764] 0.961500493583415 2.526141708765465 0.011532295341899 0.9999999999998416 0.3978585776883465 5 P11498,O00763,Q96RQ3,P05165 4 +Biotin carboxylase-like, N-terminal domain [IPR005481] 0.961500493583415 2.526141708765465 0.011532295341899 0.9999999999998416 0.3978585776883465 5 P11498,O00763,Q96RQ3,P05165 4 +Biotin carboxylase, C-terminal [IPR005482] 0.961500493583415 2.526141708765465 0.011532295341899 0.9999999999998416 0.3978585776883465 5 P11498,O00763,Q96RQ3,P05165 4 +Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 0.8316609424576816 2.157162752109961 0.0309929855734436 1.0 0.3978585776883465 6 Q9UBF8,P42345,Q9Y4A5 3 +Acetyl-CoA carboxylase [IPR034733] 0.9069264583302 2.151829164633045 0.0314108119211284 1.0 0.3978585776883465 4 O00763 1 +Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763] 0.9069264583302 2.151829164633045 0.0314108119211284 1.0 0.3978585776883465 4 O00763 1 +Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762] 0.9069264583302 2.151829164633045 0.0314108119211284 1.0 0.3978585776883465 4 O00763 1 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.862951099035985 2.1298411483850854 0.0331847302262424 1.0 0.3978585776883465 5 P55786,Q9NZ08 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.862951099035985 2.1298411483850854 0.0331847302262424 1.0 0.3978585776883465 5 P55786,Q9NZ08 2 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.8597165656075 2.116544630605237 0.0342985135785878 1.0 0.3978585776883465 5 P50213,P48735 2 +ATP-grasp fold [IPR011761] 0.7313260204968297 2.1161428952600456 0.034332656208099 1.0 0.3978585776883465 9 P11498,O00763,Q96RQ3,P05165 4 +Biotin/lipoyl attachment [IPR000089] 0.7594253527917632 2.108298690128759 0.0350051611914827 1.0 0.3978585776883465 8 P11498,P05165,Q96RQ3,O00763,Q13085 5 +Cadherin-like [IPR002126] 0.8225026231610645 1.962289180934736 0.0497288260933528 1.0 0.3999789318870316 5 Q08554,Q14574 2 +Glutathione S-transferase, N-terminal [IPR004045] 0.7158502083906029 1.9070658114203345 0.0565120658015423 1.0 0.4078236302209477 8 O15217 1 +ERAP1-like C-terminal domain [IPR024571] 0.951002959552776 1.8410551952754004 0.0656134705964281 1.0 0.4284433867023183 3 P55786,Q9NZ08 2 +Cadherin prodomain [IPR014868] 0.8273770998965543 1.8318154254100265 0.0669789242785248 1.0 0.4284433867023183 4 Q08554,Q14574 2 +Cadherin, cytoplasmic domain [IPR000233] 0.8273770998965543 1.8318154254100265 0.0669789242785248 1.0 0.4284433867023183 4 Q08554,Q14574 2 +Glutathione S-transferase, C-terminal [IPR004046] 0.6640426612143984 1.7917683250641132 0.0731700846581175 1.0 0.4358612261261331 10 O15217 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.6592095346642793 1.7678849498637208 0.0770801393291957 1.0 0.4441284218491756 10 O95302,Q9Y680,Q9NWM8,Q00688,Q13451,Q02790,P62942,P26885 8 +Gelsolin-like domain [IPR007123] 0.7752836197580008 1.7633534026077309 0.0778409036697009 1.0 0.4454813878934914 5 O95487,Q13045 2 +Zinc finger, CHHC-type [IPR012996] 0.924038145346924 1.7400892394637466 0.0818433494256249 1.0 0.4543332098222198 3 P55795,P52597 2 +Importin-beta, N-terminal domain [IPR001494] 0.6465090674525484 1.712079443672632 0.0868820290551248 1.0 0.4637967139266225 13 O00410,O43592,Q92973,O14980,Q8TEX9,Q9UI26,Q96P70,Q9UIA9,O15397,P55060 10 +PIK-related kinase, FAT [IPR003151] 0.8983886879315996 1.643485332744807 0.1002825575592551 1.0 0.4986653204658854 3 P42345,Q9Y4A5 2 +PIK-related kinase [IPR014009] 0.8983886879315996 1.643485332744807 0.1002825575592551 1.0 0.4986653204658854 3 P42345,Q9Y4A5 2 +FATC domain [IPR003152] 0.8983886879315996 1.643485332744807 0.1002825575592551 1.0 0.4986653204658854 3 P42345,Q9Y4A5 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.7717250794035806 1.6029029349625596 0.1089560856228872 1.0 0.5118236678136256 4 Q96CP7 1 +Glutathione S-transferase, C-terminal-like [IPR010987] 0.6217605430328228 1.580720849040971 0.1139418791122053 1.0 0.5160896877435183 11 O15217 1 +Zinc finger, MYND-type [IPR002893] 0.8777380439241229 1.56537819392775 0.117494258311138 1.0 0.5254654031396813 3 Q9H7B4 1 +OTU domain [IPR003323] 0.8716452311171399 1.542286943809419 0.1230038802462922 1.0 0.5416860653480566 3 Q6GQQ9 1 +HECT domain [IPR000569] 0.6081169165318459 1.515106650526743 0.129745397746932 1.0 0.551222930670062 9 O95071,Q96PU5,Q15386 3 +SET domain [IPR001214] 0.6065217333038211 1.5039365635325364 0.1325977013653343 1.0 0.557843474472319 12 Q9H7B4 1 +Sec23/Sec24, trunk domain [IPR006896] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.5716372410608234 4 O95487 1 +Zinc finger, Sec23/Sec24-type [IPR006895] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.5716372410608234 4 O95487 1 +Sec23/Sec24, helical domain [IPR006900] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.5716372410608234 4 O95487 1 +Sec23/Sec24 beta-sandwich [IPR012990] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.5716372410608234 4 O95487 1 +Proteasome component (PCI) domain [IPR000717] 0.5898135991878873 1.4437215383640605 0.1488173203277727 1.0 0.5716372410608234 17 Q9UNM6,O00231,O00232,Q99627,P60228,Q9BT78,Q7L2H7,Q14152,Q9Y262,Q9UNS2,Q9UBQ5,Q15008 12 +VHS domain [IPR002014] 0.8422608096781263 1.4307073219718422 0.152514113880688 1.0 0.574998359374654 3 O60784 1 +Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364] 0.723226767276595 1.401012859734552 0.1612102276199323 1.0 0.574998359374654 4 Q15046 1 +AP complex, mu/sigma subunit [IPR022775] 0.657319215208658 1.3917722309810618 0.1639913814458686 1.0 0.574998359374654 6 Q92572 1 +Sec24-like, trunk domain [IPR041742] 0.8232974155391557 1.358590942041382 0.1742762470589491 1.0 0.5899446469395122 3 O95487 1 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.8128904965471839 1.319011680111729 0.1871652076630581 1.0 0.6166253732190161 3 Q7L576,Q96F07 2 +Zinc finger, RanBP2-type [IPR001876] 0.5681478752124924 1.313824862555506 0.1889051487557789 1.0 0.6196666787352594 9 Q92804,P35637,Q01844 3 +Chaperone DnaJ, C-terminal [IPR002939] 0.8104045804520501 1.3095592064503947 0.1903449962494199 1.0 0.620881431925258 3 O60884 1 +Bromo adjacent homology (BAH) domain [IPR001025] 0.6967325163808114 1.2902382874564051 0.1969679363391498 1.0 0.6367627560277098 4 O94776,P26358 2 +DnaJ domain [IPR001623] 0.5598846333986072 1.2687536704513855 0.2045289337270217 1.0 0.6488239957557581 15 O60884,Q13217,O75165,Q99615,Q99543,P31689 6 +von Willebrand factor, type A [IPR002035] 0.6258529383971888 1.2496451883236168 0.2114291881340126 1.0 0.661393657735057 6 Q96SY0,Q9NU22 2 +Guanylate kinase-like domain [IPR008144] 0.613767814640258 1.1949907869895866 0.2320906297001121 1.0 0.666375469003373 6 Q14168,Q9UDY2 2 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.613767814640258 1.1949907869895866 0.2320906297001121 1.0 0.666375469003373 6 Q14168,Q9UDY2 2 +CSN8/PSMD8/EIF3K [IPR033464] 0.774358313266821 1.1727417941830205 0.2408993658416849 1.0 0.6766342131982458 3 Q99627 1 +Exportin-1/Importin-beta-like [IPR013598] 0.6661184210526385 1.162292516732491 0.2451166652713445 1.0 0.6815211212907012 4 Q9Y5L0,O14980,O43592 3 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.7690006105895117 1.1524713017502055 0.2491274559957164 1.0 0.6858427580553796 3 Q9BYT8 1 +Proteasome alpha-subunit, N-terminal domain [IPR000426] 0.5762767645209298 1.1285825747528846 0.2590739648902185 1.0 0.7018197705608158 7 P25786,P60900 2 +GNAT domain [IPR000182] 0.6268929937111176 1.1225831236029804 0.2616145862032084 1.0 0.7036724947336072 5 Q86UY6 1 +GMP phosphodiesterase, delta subunit [IPR008015] 0.979947403024328 1.0932664505743592 0.2742768286022961 1.0 0.7111606341616676 2 A6NIH7 1 +START domain [IPR002913] 0.9796186719263652 1.092148189728654 0.2747679709279764 1.0 0.711707863535156 2 Q9NQZ5 1 +GINS subunit, domain A [IPR021151] 0.7497900840995978 1.0800147522635346 0.2801356109436894 1.0 0.7190147347554695 3 Q9Y248 1 +MENTAL domain [IPR019498] 0.9746877054569368 1.075392524593057 0.2821990272154968 1.0 0.7206710835724396 2 Q14849 1 +Cyclin, N-terminal [IPR006671] 0.7423729097555287 1.052155119969422 0.292728386570487 1.0 0.7306707566558032 3 O95067 1 +Cyclin, C-terminal domain [IPR004367] 0.7423729097555287 1.052155119969422 0.292728386570487 1.0 0.7306707566558032 3 O95067 1 +Cyclin-like [IPR013763] 0.7423729097555287 1.052155119969422 0.292728386570487 1.0 0.7306707566558032 3 O95067 1 +Tudor domain [IPR002999] 0.5379688381683134 1.0515136004768897 0.2930227662785214 1.0 0.7306877812696005 8 Q14739 1 +PIN domain [IPR002716] 0.7412035514633197 1.0477697960787924 0.2947446815005923 1.0 0.7321077572756647 3 Q9UPR3,Q9ULX3 2 +Helicase/UvrB, N-terminal [IPR006935] 0.7376937161875103 1.034619271051464 0.3008467505903773 1.0 0.7378876382723444 3 P19447 1 +YTH domain [IPR007275] 0.7363744645086066 1.0296811700083444 0.3031596977266444 1.0 0.738891790766688 3 Q7Z739 1 +Acetyl-CoA carboxylase, central domain [IPR013537] 0.9605522682445752 1.0275637673563287 0.3041550751837114 1.0 0.739577077551972 2 O00763 1 +OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365] 0.6003249540796174 1.007759691365185 0.3135698411708514 1.0 0.749313444925609 5 Q15046 1 +MHC class I-like antigen recognition-like [IPR011161] 0.6174342105263239 0.9604513092848772 0.3368281252837692 1.0 0.7669178013853564 4 P10321,Q9UNN8,P04439 3 +DNA2/NAM7 helicase-like, C-terminal [IPR041679] 0.5874115760106483 0.952321292814545 0.3409340623178218 1.0 0.7680922070678603 5 Q9HCE1,P51530 2 +Kinesin motor domain [IPR001752] 0.4998386209327945 0.9519501733848048 0.3411222521772008 1.0 0.7680922070678603 12 Q86Y91,Q96Q89,Q02241,Q9BW19 4 +Immunoglobulin subtype 2 [IPR003598] 0.4971063988084053 0.947171408350515 0.34355144215207 1.0 0.7691314665272333 10 Q5ZPR3 1 +Ribosomal protein L18e/L15P [IPR021131] 0.7124163307096388 0.9405340181025956 0.346943708801652 1.0 0.7712895573622028 3 P46776 1 +WW domain [IPR001202] 0.4974634672762807 0.9363470387536614 0.3490945366253926 1.0 0.7742774152596136 14 Q13526,Q96PU5,O60828,Q8N1G2 4 +TGS [IPR004095] 0.5464121132323865 0.8923321392798707 0.3722149325111101 1.0 0.7997283972268924 6 Q9NYK5,P55039,Q9BW92,P26639,Q9NTK5 5 +Death domain [IPR000488] 0.6991614743439301 0.8917301092325496 0.3725376109356086 1.0 0.7997283972268924 3 Q13546 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.9178172255095344 0.8852618575564708 0.3760154167295009 1.0 0.7997283972268924 2 P98179 1 +Serine hydroxymethyltransferase-like domain [IPR039429] 0.916502301117689 0.8809492034935978 0.3783453142737589 1.0 0.7997283972268924 2 P34897 1 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.9066403681788286 0.8487510441812823 0.3960198364593952 1.0 0.8154671024662263 2 Q9NVE7 1 +Initiation factor eIF-4 gamma, MA3 [IPR003891] 0.5584073708456861 0.8292112091873526 0.4069849032508497 1.0 0.82384568362965 5 Q53EL6,O43432,Q04637,Q5C9Z4 4 +Glutamine amidotransferase [IPR017926] 0.5830658768934377 0.8207788305288369 0.4117722589258021 1.0 0.8292848005264684 4 P17812,Q9NRF8 2 +Transcription factor IIS, N-terminal [IPR017923] 0.580758957597528 0.8115321185265992 0.4170601558378344 1.0 0.836424511431679 4 Q96ST2 1 +Zinc finger, ZZ-type [IPR000433] 0.5789758108856558 0.8043979550352173 0.421167181833793 1.0 0.8400371520734758 4 Q13501,P46939 2 +B-box-type zinc finger [IPR000315] 0.5511379896927012 0.7987561812782707 0.4244318031954608 1.0 0.8403103492188079 5 Q9UPN9,P19474 2 +HD domain [IPR006674] 0.8879026955950108 0.7883509764735821 0.4304914376586675 1.0 0.8403103492188079 2 Q7Z4H3 1 +HD/PDEase domain [IPR003607] 0.8879026955950108 0.7883509764735821 0.4304914376586675 1.0 0.8403103492188079 2 Q7Z4H3 1 +Protein Kinase B, pleckstrin homology domain [IPR039026] 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 0.842729744650479 2 P31751 1 +ELM2 domain [IPR000949] 0.6642551792173523 0.7655765887106158 0.443928278932268 1.0 0.8492853597672924 3 Q13330,O94776 2 +Polyketide synthase, enoylreductase domain [IPR020843] 0.5172970458267103 0.7644376671189395 0.4446064691417264 1.0 0.8492853597672924 6 Q14914 1 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.4619719582980345 0.7554089247224415 0.4500036599236452 1.0 0.8522159895887672 13 Q9UPU5,Q93008,Q96K76,Q96RU2 4 +Ubiquitin specific protease domain [IPR028889] 0.4619719582980345 0.7554089247224415 0.4500036599236452 1.0 0.8522159895887672 13 Q9UPU5,Q93008,Q96K76,Q96RU2 4 +Zinc finger, RING-type [IPR001841] 0.4525321827611388 0.7468982157508046 0.4551250030739593 1.0 0.8576655563447765 23 O95376,O96028,P22681,O95628,Q13263,O94822,Q5VTB9,Q99496,P19474,Q99590,Q9UPN9 11 +NOPS [IPR012975] 0.6514304505096954 0.7203036317824744 0.4713380691406608 1.0 0.8776384327226394 3 Q15233,P23246 2 +Zinc finger, UBR-type [IPR003126] 0.8662064431295189 0.7198687570182716 0.4716058060110057 1.0 0.8776384327226394 2 Q5T4S7 1 +Exportin-2, central domain [IPR013713] 0.6509430374808132 0.718596360042207 0.472389656783855 1.0 0.8776384327226394 3 O15397 1 +Translation initiation factor, beta propellor-like domain [IPR013979] 0.647484380138099 0.7065112761627003 0.4798702428110442 1.0 0.881670489503155 3 P55884,Q96J01 2 +MCM N-terminal domain [IPR027925] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.8949243120730008 6 P33991,P33993 2 +MCM domain [IPR001208] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.8949243120730008 6 P33991,P33993 2 +MCM, AAA-lid domain [IPR041562] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.8949243120730008 6 P33991,P33993 2 +MCM OB domain [IPR033762] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.8949243120730008 6 P33991,P33993 2 +Rpn11/EIF3F, C-terminal [IPR024969] 0.5384282417998614 0.6459053247689311 0.518340670970822 1.0 0.910230577012342 4 P51665,Q7L5N1 2 +CTP synthase GATase domain [IPR033828] 0.8405654174884915 0.6413085162636741 0.5213222572193084 1.0 0.912942698548768 2 P17812 1 +CTP synthase, N-terminal [IPR017456] 0.8405654174884915 0.6413085162636741 0.5213222572193084 1.0 0.912942698548768 2 P17812 1 +L27 domain [IPR004172] 0.8339907955292529 0.6216337709158791 0.5341827096394223 1.0 0.9201313298405344 2 Q14168 1 +L27 domain, C-terminal [IPR014775] 0.8339907955292529 0.6216337709158791 0.5341827096394223 1.0 0.9201313298405344 2 Q14168 1 +Ubiquitin-like domain [IPR000626] 0.4325584433334546 0.6060471423395382 0.5444834491520827 1.0 0.9292074632328302 14 Q5TDH0,Q8NCF5 2 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 0.9292074632328302 3 P10321,P04439 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 0.9292074632328302 3 P10321,P04439 2 +EF-hand domain [IPR002048] 0.3488616557153158 0.5989961645858742 0.5491754422140431 1.0 0.9316286778246158 41 P80303,Q9Y680,P60660,P41208,O43852,Q9NWM8,Q9BRK5,Q15293,Q14257,O95302,Q02818 11 +Immunoglobulin subtype [IPR003599] 0.4285667795765565 0.594865629590319 0.5519332935616119 1.0 0.9329681019359533 12 Q5ZPR3 1 +Peptidase M20, dimerisation domain [IPR011650] 0.824786324786321 0.5944409186317727 0.5522172472694504 1.0 0.9329681019359533 2 Q96KP4 1 +Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245] 0.4249333102351852 0.5907805792253065 0.5546674491279857 1.0 0.9346220081128724 10 Q05397 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.8218277449046674 0.5857910087580522 0.5580159666216178 1.0 0.9365933389330368 2 O60884 1 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058] 0.6113120683985402 0.5836398360828332 0.55946265285052 1.0 0.9371091634101326 3 Q5JPH6,P07814 2 +Lsm14-like, N-terminal [IPR025609] 0.8162393162393184 0.5695770535337156 0.5689645955250502 1.0 0.9381823732830322 2 Q9BX40 1 +DFDF domain [IPR025762] 0.8162393162393184 0.5695770535337156 0.5689645955250502 1.0 0.9381823732830322 2 Q9BX40 1 +FDF domain [IPR019050] 0.8162393162393184 0.5695770535337156 0.5689645955250502 1.0 0.9381823732830322 2 Q9BX40 1 +Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297] 0.8119658119658089 0.5572910910497153 0.5773285616116512 1.0 0.9426757800167948 2 Q13526 1 +JmjC domain [IPR003347] 0.5994949905022281 0.5451103916268574 0.5856775960782583 1.0 0.950196491336555 3 Q8IUF8 1 +EF-hand, Ca insensitive [IPR014837] 0.5971719829003598 0.5376425850886479 0.5908238243583441 1.0 0.950196491336555 3 O43707,Q13813 2 +EGF-like calcium-binding domain [IPR001881] 0.4451836099869378 0.5347451627203742 0.5928260872086564 1.0 0.9509691998591426 7 P48960 1 +Zinc finger, GATA-type [IPR000679] 0.5907825872851735 0.517292085112278 0.6049522783579395 1.0 0.9573180660278664 3 O94776 1 +STAT transcription factor, DNA-binding [IPR013801] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.9573180660278664 2 P40763 1 +STAT transcription factor, protein interaction [IPR013799] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.9573180660278664 2 P40763 1 +STAT transcription factor, all-alpha domain [IPR013800] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.9573180660278664 2 P40763 1 +Coatomer, WD associated region [IPR006692] 0.795529257067715 0.5109975057868438 0.6093528032875848 1.0 0.9573180660278664 2 P35606 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.7879684418146016 0.4902418868647853 0.6239627438496416 1.0 0.9573180660278664 2 O60506 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7836949375410924 0.4786685596531597 0.6321744360500889 1.0 0.9573180660278664 2 Q92945 1 +Cullin protein, neddylation domain [IPR019559] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.9596833052038322 5 Q13616,Q13617,Q13618,Q13620 4 +Cullin, N-terminal [IPR001373] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.9596833052038322 5 Q13616,Q13617,Q13618,Q13620 4 +Cullin homology domain [IPR016158] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.9596833052038322 5 Q13616,Q13617,Q13618,Q13620 4 +Protein kinase domain [IPR000719] 0.3049864827062163 0.4659734077391352 0.6412345351292297 1.0 0.9596833052038322 59 P17612,Q05397,Q9UHY1,P78362,Q86UE8,P48729,P11802,P50750,P31751,Q13555,P31749 11 +DNA2/NAM7 helicase, helicase domain [IPR041677] 0.4854038366436589 0.4540174707529015 0.6498162522447077 1.0 0.9632838973806982 4 P51530 1 +F-box domain [IPR001810] 0.7698882314266894 0.4420929092696034 0.658421975257597 1.0 0.9661574455843632 2 Q14241 1 +SKP1 component, POZ domain [IPR016073] 0.7692307692307724 0.4403832245877427 0.6596595727453745 1.0 0.9661574455843632 2 P63208 1 +Sterile alpha motif domain [IPR001660] 0.4352740367510703 0.4290402725661206 0.6678939169977358 1.0 0.9711664860761484 6 Q92625,Q15375,Q9Y3Z3 3 +Pleckstrin homology domain [IPR001849] 0.3931915916479039 0.418594928546952 0.6755121965931434 1.0 0.974142534577909 20 O14654,P31751,P22059,Q92888,P31749 5 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.551134495231827 0.3979715203733818 0.6906511790043046 1.0 0.979750407897582 3 P51784,Q86UV5 2 +N-acetylgalactosaminyltransferase [IPR045885] 0.5483226273580886 0.3900141206138729 0.6965261053930556 1.0 0.9822481550025456 3 Q10471 1 +DNA polymerase alpha/delta/epsilon, subunit B [IPR007185] 0.7458908612754982 0.3816874271116123 0.7026932270171802 1.0 0.9854206444588276 2 Q14181 1 +Domain of unknown function DUF3517 [IPR021905] 0.7445759368836231 0.3785005343229763 0.7050587969111466 1.0 0.9859958189054614 2 Q9UPU5 1 +Dual specificity protein phosphatase domain [IPR020422] 0.741617357001968 0.3713785660795051 0.7103555876902643 1.0 0.9893876205531186 2 P51452 1 +Dual specificity phosphatase, catalytic domain [IPR000340] 0.741617357001968 0.3713785660795051 0.7103555876902643 1.0 0.9893876205531186 2 P51452 1 +Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152] 0.4366567949983709 0.3610636640338495 0.7180518554616577 1.0 0.9898259167915744 5 O43747,Q10567,O94973,Q9UJY4 4 +Metastasis-associated protein MTA1, R1 domain [IPR035170] 0.7347140039447667 0.3550257489736944 0.7225703012418911 1.0 0.991388302081882 2 O94776 1 +Zinc finger, UBP-type [IPR001607] 0.5304176257809811 0.34110143113877 0.7330272238770572 1.0 0.9997971958516384 3 P45974,Q8TEY7 2 +Peptidase M16, middle/third domain [IPR032632] 0.7222222222222381 0.3264041759787714 0.7441185784235052 1.0 1.0 2 O43847 1 +Aminoacyl-tRNA synthetase, class II [IPR006195] 0.3664167850370857 0.3241142126790814 0.7458515670907515 1.0 1.0 11 Q9NP81,Q15046 2 +NADP-dependent oxidoreductase domain [IPR023210] 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 O43488,P14550 2 +Alpha-D-phosphohexomutase, C-terminal [IPR005843] 0.7067718606180154 0.2927982850941867 0.769676339136832 1.0 1.0 2 Q96G03 1 +PDZ domain [IPR001478] 0.3643242042640252 0.2905670383107819 0.7713824724588831 1.0 1.0 20 Q9HD26,Q53GG5,P57105,Q9UDY2,Q14168,Q9NZW5 6 +Zinc finger, CCHC-type [IPR001878] 0.3660540255603997 0.284044834989469 0.7763760216723175 1.0 1.0 8 Q15637,Q9NUD5,O95639,Q9BWF3 4 +Domain of unknown function DUF1605 [IPR011709] 0.3593610449752727 0.2839185617122121 0.7764727914053124 1.0 1.0 13 O60231,Q9H2U1,Q14562,Q92620,O43143,Q6P158,Q8IX18 7 +Helicase-associated domain [IPR007502] 0.3593610449752727 0.2839185617122121 0.7764727914053124 1.0 1.0 13 O60231,Q9H2U1,Q14562,Q92620,O43143,Q6P158,Q8IX18 7 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Glycosyl transferase, family 1 [IPR001296] 0.4225186558600114 0.2619102125177903 0.7933906659366066 1.0 1.0 4 Q9H553 1 +Immunoglobulin-like domain [IPR007110] 0.3562514386931407 0.260383371431019 0.7945680683710745 1.0 1.0 16 Q5ZPR3 1 +Zinc finger, LIM-type [IPR001781] 0.3452683138779406 0.242522362722769 0.8083754310293545 1.0 1.0 11 Q53GG5,Q16527 2 +Bromodomain [IPR001487] 0.3491089827871624 0.233245355913944 0.815570888008017 1.0 1.0 16 Q9UPN9,Q9H8M2,Q9NPI1 3 +APC10/DOC domain [IPR004939] 0.6765285996055199 0.2330712907476256 0.8157060477012876 1.0 1.0 2 Q5T447 1 +Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378] 0.3742593811718264 0.2239847622024374 0.8227691600319613 1.0 1.0 6 Q9BVP2,Q9H089,P36915,Q9NVN8,Q8NC60 5 +Fxr1, tudor domain [IPR041560] 0.4798478514475378 0.2212401121639516 0.8249054780112719 1.0 1.0 3 Q06787 1 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.4798478514475378 0.2212401121639516 0.8249054780112719 1.0 1.0 3 Q06787 1 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.4798478514475378 0.2212401121639516 0.8249054780112719 1.0 1.0 3 Q06787 1 +Agenet-like domain [IPR008395] 0.4798478514475378 0.2212401121639516 0.8249054780112719 1.0 1.0 3 Q06787 1 +Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040] 0.6646942800788944 0.2119686685772241 0.8321314777528488 1.0 1.0 2 Q9Y678 1 +Coatomer subunit gamma, C-terminal [IPR032154] 0.6646942800788944 0.2119686685772241 0.8321314777528488 1.0 1.0 2 Q9Y678 1 +Zinc finger, FYVE-related [IPR017455] 0.6623931623931605 0.208016773519004 0.8352158704438724 1.0 1.0 2 Q9P2R3 1 +FYVE zinc finger [IPR000306] 0.6623931623931605 0.208016773519004 0.8352158704438724 1.0 1.0 2 Q9P2R3 1 +Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038] 0.6584483892176172 0.2013574229152592 0.8404191049142333 1.0 1.0 2 P29692 1 +Elongation factor 1 beta central acidic region, eukaryote [IPR018940] 0.6584483892176172 0.2013574229152592 0.8404191049142333 1.0 1.0 2 P29692 1 +CARG-binding factor, N-terminal [IPR012956] 0.6528599605522645 0.1921733816158574 0.8476063956715465 1.0 1.0 2 Q14103 1 +B30.2/SPRY domain [IPR001870] 0.3291217049723554 0.1859352662843977 0.852495525907127 1.0 1.0 11 Q9UBL3,P19474,Q9BUJ2 3 +SPRY domain [IPR003877] 0.3291217049723554 0.1859352662843977 0.852495525907127 1.0 1.0 11 Q9UBL3,P19474,Q9BUJ2 3 +MPN domain [IPR037518] 0.3286249764400232 0.1842797320658207 0.853794013103002 1.0 1.0 11 O43402,Q8TAT6,Q92905,Q7L5N1,O15372 5 +Dynamin, GTPase domain [IPR001401] 0.4557711279184346 0.1746833126255487 0.8613284807533532 1.0 1.0 3 P50570,O60313 2 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.6380670611439894 0.1692820826046737 0.8655747685977973 1.0 1.0 2 Q13505 1 +Metaxin, glutathione S-transferase domain [IPR033468] 0.6380670611439894 0.1692820826046737 0.8655747685977973 1.0 1.0 2 Q13505 1 +Peptidase M16, N-terminal [IPR011765] 0.3421636817329086 0.1670937347773127 0.8672962956354322 1.0 1.0 7 O43847,P31930 2 +Peptidase M16, C-terminal [IPR007863] 0.3421636817329086 0.1670937347773127 0.8672962956354322 1.0 1.0 7 O43847,P31930 2 +PB1 domain [IPR000270] 0.4455771127918334 0.1571278521484021 0.8751440873799665 1.0 1.0 3 Q13501,Q92734 2 +NAD-dependent epimerase/dehydratase [IPR001509] 0.6295200525969702 0.1569951505359846 0.8752486700208948 1.0 1.0 2 Q13630 1 +SPRY-associated [IPR006574] 0.3632773938795762 0.1557085429039718 0.8762627630462905 1.0 1.0 5 P19474,Q7KYR7,Q14258,O15344 4 +Butyrophylin-like, SPRY domain [IPR003879] 0.3632773938795762 0.1557085429039718 0.8762627630462905 1.0 1.0 5 P19474,Q7KYR7,Q14258,O15344 4 +26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.6278763971071606 0.1547108986931106 0.8770492375375807 1.0 1.0 2 Q15008 1 +Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481] 0.6219592373438467 0.1466967552474569 0.883371379834405 1.0 1.0 2 Q96KP1 1 +ZU5 domain [IPR000906] 0.6209730440499611 0.1453928080776205 0.8844007426525453 1.0 1.0 2 Q12955 1 +C2 domain [IPR000008] 0.3175363852937009 0.1379781416404807 0.8902576927413004 1.0 1.0 13 Q99829,Q16513,Q05655,Q96PU5,Q96J02 5 +CID domain [IPR006569] 0.3410138248847952 0.1365550874584603 0.8913824788557871 1.0 1.0 6 O15042,Q9NQG5,Q96P16,Q8IWX8,O95104 5 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059] 0.611111111111107 0.1328488864359855 0.8943128911901996 1.0 1.0 2 P07814 1 +FCP1 homology domain [IPR004274] 0.6002629848783646 0.1200797644356423 0.9044199620321736 1.0 1.0 2 Q3ZCQ8 1 +SH3 domain [IPR001452] 0.3083412318697192 0.1190495179208892 0.9052361250725196 1.0 1.0 29 Q9UDY2,A1X283,P15924,Q92783,Q9UQB8,Q14168 6 +Anaphase-promoting complex subunit 4, WD40 domain [IPR024977] 0.3214821415235561 0.1141693994037774 0.9091035090028814 1.0 1.0 7 Q12834,P53621 2 +Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186] 0.3399740639586687 0.108404076312854 0.9136751677628344 1.0 1.0 5 O00743 1 +Nucleoside diphosphate kinase-like domain [IPR034907] 0.4119312231343535 0.1083149391363728 0.913745872618294 1.0 1.0 3 P22392 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.3038597581874446 0.103410043677649 0.9176375411814744 1.0 1.0 12 Q01085,O95628,Q9UHX1,P38159,Q14011 5 +RWD domain [IPR006575] 0.5834976988823057 0.1024131240492293 0.918428766961026 1.0 1.0 2 Q6P158 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.3457236842105332 0.1013267440846149 0.9192910867369266 1.0 1.0 4 Q7Z406,Q9UM54,P35580 3 +AAA+ ATPase domain [IPR003593] 0.2278352530509054 0.0987006376216354 0.921375962590107 1.0 1.0 49 Q96QE3,Q8NB90,O14678 3 +Proteasomal ATPase OB C-terminal domain [IPR032501] 0.3333333333333446 0.0966199221686995 0.9230282349129972 1.0 1.0 5 P62195,P62333,P17980,P62191 4 +Myosin head, motor domain [IPR001609] 0.3022403562586372 0.0911241038531583 0.9273939802132156 1.0 1.0 8 O43795 1 +PAP/25A-associated [IPR002058] 0.5713346482577161 0.0911119371833147 0.9274036475961338 1.0 1.0 2 Q9NVV4 1 +TUTase nucleotidyltransferase domain [IPR045100] 0.5713346482577161 0.0911119371833147 0.9274036475961338 1.0 1.0 2 Q9NVV4 1 +BTB/POZ domain [IPR000210] 0.3277038276851285 0.0872175363325786 0.9304986004950272 1.0 1.0 5 Q14145,Q9NXV2 2 +Brix domain [IPR007109] 0.331884602598868 0.0820358559890552 0.9346182005807742 1.0 1.0 4 Q9H7B2 1 +CS domain [IPR007052] 0.2981079730332621 0.0815265573661795 0.9350232054475112 1.0 1.0 8 Q9UHD1,Q9Y2Z0,Q8WVJ2 3 +Ancestral coatomer element 1, Sec16/Sec31 [IPR024298] 0.559500328731088 0.0812835809779782 0.93521643126099 1.0 1.0 2 O15027 1 +IMP dehydrogenase/GMP reductase [IPR001093] 0.5588428665351666 0.0807702109593559 0.9356246988547784 1.0 1.0 2 P20839 1 +Translation elongation factor EFTu/EF1A, C-terminal [IPR004160] 0.3299342105263269 0.0795475954190526 0.9365970758544152 1.0 1.0 4 Q9Y450,P49411,Q05639 3 +Threonine-tRNA ligase catalytic core domain [IPR033728] 0.5568704799473929 0.0792502819934198 0.9368335510770288 1.0 1.0 2 Q9BW92 1 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.5558842866535162 0.07850160536541 0.9374290532685272 1.0 1.0 2 Q93009 1 +Aminotransferase, class I/classII [IPR004839] 0.3116362622655756 0.0760297033286485 0.9393954667451924 1.0 1.0 6 O15270 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.3247279322861452 0.0731782395243431 0.9416642822974036 1.0 1.0 4 Q16352 1 +Ribosomal protein S5, N-terminal [IPR013810] 0.5335305719921 0.0634658723119335 0.9493955343867246 1.0 1.0 2 P15880 1 +Ribosomal protein S5, C-terminal [IPR005324] 0.5335305719921 0.0634658723119335 0.9493955343867246 1.0 1.0 2 P15880 1 +Extended synaptotagmin, C2A domain [IPR037733] 0.5279421433267468 0.0602556027627062 0.9519520615214704 1.0 1.0 2 A0FGR8 1 +Synaptotagmin, SMP domain [IPR039010] 0.5279421433267468 0.0602556027627062 0.9519520615214704 1.0 1.0 2 A0FGR8 1 +Extended synaptotagmin, C2B domain [IPR037749] 0.5279421433267468 0.0602556027627062 0.9519520615214704 1.0 1.0 2 A0FGR8 1 +Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.5279421433267468 0.0602556027627062 0.9519520615214704 1.0 1.0 2 A0FGR8 1 +Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.5279421433267468 0.0602556027627062 0.9519520615214704 1.0 1.0 2 A0FGR8 1 +RNA polymerase Rpb2, domain 3 [IPR007645] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 7 [IPR007641] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase, beta subunit, protrusion [IPR007644] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 [IPR007642] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +Gamma-adaptin ear (GAE) domain [IPR008153] 0.5216962524654709 0.0569096501406563 0.95461716707272 1.0 1.0 2 Q9UJY4 1 +Phosphofructokinase domain [IPR000023] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 1.0 3 P08237 1 +Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553] 0.2764415156507473 0.0517605449265184 0.9587194939724332 1.0 1.0 9 Q10567,O94973,O14617,O43747,P63010,Q9Y678,P53618,Q9UBF2 8 +Myosin tail [IPR002928] 0.3456099967116149 0.0498891819211088 0.960210698145944 1.0 1.0 3 Q7Z406,P35580 2 +Staufen, C-terminal [IPR032478] 0.4993425378040639 0.0468666476584528 0.9626195101836998 1.0 1.0 2 O75569 1 +Peptidase M24 [IPR000994] 0.2932850559578698 0.0463631321839219 0.9630208211518488 1.0 1.0 6 Q9UQ80,Q9NQW7,P50579,Q9NQH7,Q9Y5B9 5 +Fumarate lyase, N-terminal [IPR022761] 0.4970414201183319 0.0459911079456646 0.963317337242958 1.0 1.0 2 P07954 1 +PTB/PI domain [IPR006020] 0.3350871423873746 0.0444895161938745 0.9645142085693008 1.0 1.0 3 Q92625,O60343 2 +ENTH domain [IPR013809] 0.3344294639921089 0.0441809738672814 0.9647601478973652 1.0 1.0 3 Q13492,O00291 2 +Ribosomal protein S10 domain [IPR027486] 0.4878369493753967 0.0427573259971151 0.9658949817782776 1.0 1.0 2 P60866 1 +Poly(ADP-ribose) polymerase, catalytic domain [IPR012317] 0.4783037475345046 0.0398324345105124 0.968226717742843 1.0 1.0 2 Q7Z2W4 1 +Domain of unknown function DUF1899 [IPR015048] 0.3232489312726108 0.0394205484112153 0.968555097378214 1.0 1.0 3 P57737,Q9ULV4 2 +SAB domain [IPR007477] 0.3166721473199673 0.0370216326178547 0.9704677572275132 1.0 1.0 3 P11171,O43491 2 +Band 4.1, C-terminal [IPR008379] 0.3166721473199673 0.0370216326178547 0.9704677572275132 1.0 1.0 3 P11171,O43491 2 +Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768] 0.2851973684210589 0.0368393847941423 0.9706130708244164 1.0 1.0 4 Q9NSV4,O60610,Q9Y613 3 +Formin, FH2 domain [IPR015425] 0.2851973684210589 0.0368393847941423 0.9706130708244164 1.0 1.0 4 Q9NSV4,O60610,Q9Y613 3 +Mib-herc2 [IPR010606] 0.4651545036160279 0.0364361046517749 0.9709346259334476 1.0 1.0 2 O95714 1 +Putative RNA methylase domain [IPR000241] 0.4621959237343732 0.0357650006648244 0.9714697406255748 1.0 1.0 2 Q7Z4G4 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.272875657538022 0.0293524559108759 0.976583491135924 1.0 1.0 4 P14866 1 +AARP2CN [IPR012948] 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 1.0 2 Q2NL82 1 +Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 1.0 2 Q2NL82 1 +Bms1/Tsr1-type G domain [IPR030387] 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 1.0 2 Q2NL82 1 +Septin-type guanine nucleotide-binding (G) domain [IPR030379] 0.2847747451496275 0.0288647189350643 0.9769724841011012 1.0 1.0 3 Q15019,Q9UHD8 2 +U2A'/phosphoprotein 32 family A, C-terminal [IPR003603] 0.2732653732324955 0.0270481236935842 0.9784213508984728 1.0 1.0 3 Q92688,P39687 2 +AP180 N-terminal homology (ANTH) domain [IPR011417] 0.3888888888888845 0.026825150777838 0.978599193013794 1.0 1.0 2 Q13492 1 +Phospholipase/carboxylesterase/thioesterase [IPR003140] 0.3717948717948673 0.0260950526634384 0.9791815231231068 1.0 1.0 2 Q5VWZ2 1 +Ribosomal protein L7, eukaryotic/archaeal [IPR035808] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 1.0 2 P18124 1 +Ribosomal protein L30, N-terminal [IPR012988] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 1.0 2 P18124 1 +Ribosomal protein L30, ferredoxin-like fold domain [IPR016082] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 1.0 2 P18124 1 +Ricin B, lectin domain [IPR000772] 0.2723491946412535 0.021837921813569 0.9825772441596334 1.0 1.0 5 Q10471 1 +Peroxiredoxin, C-terminal [IPR019479] 0.2559210526315896 0.0214775950973834 0.9828646758627206 1.0 1.0 4 Q13162,P30048,P30041 3 +Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866] 0.2559210526315896 0.0214775950973834 0.9828646758627206 1.0 1.0 4 Q13162,P30048,P30041 3 +SNF2, N-terminal [IPR000330] 0.2679468898128192 0.0176319793540109 0.985932444803442 1.0 1.0 13 Q12873,Q9H4L7 2 +High mobility group box domain [IPR009071] 0.2615435356200611 0.0096415059446511 0.9923073104477144 1.0 1.0 12 P17480,P26583,Q86U86,O96028,Q969G3,P54277,P09429,Q08945,O94842,O15347,O75717 11 +La-type HTH domain [IPR006630] 0.2436904992055359 0.004445398076708 0.9964530971900336 1.0 1.0 5 Q4G0J3,Q71RC2 2 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.2522756225651338 2.666356503244738e-05 0.9999787255531272 1.0 1.0 8 Q92905,O15372,Q7L5N1 3 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7b3df6dd0e5ad504a5634de9e08814068772f78f --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abl Interactor 1, SH3 domain [IPR035725]", "Abl-interactor, homeo-domain homologous domain [IPR012849]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain [IPR041805]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Activin types I and II receptor domain [IPR000472]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Adaptor protein Cbl, EF hand-like [IPR014741]", "Adaptor protein Cbl, N-terminal helical [IPR003153]", "Adaptor protein Cbl, PTB domain [IPR024159]", "Adaptor protein Cbl, SH2-like domain [IPR014742]", "Adenomatous polyposis coli protein basic domain [IPR009234]", "Adenomatous polyposis coli, N-terminal dimerisation domain [IPR032038]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1 [IPR041880]", "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2 [IPR041882]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apolipoprotein B100 C-terminal [IPR022176]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCL-6 corepressor, PCGF1 binding domain [IPR032365]", "BCL-6 corepressor, non-ankyrin-repeat domain [IPR031628]", "BCL10, CARD domain [IPR042143]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-mannosidase, Ig-fold domain [IPR041625]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brd8, Bromo domain [IPR037966]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Bud22 domain [IPR015158]", "Butyrophilin subfamily 1/2, SPRY/PRY domain [IPR037958]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CALCOCO1/2, zinc finger UBZ1-type [IPR041641]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARD domain [IPR001315]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLIP1, zinc knuckle [IPR032108]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "CNOT4, RNA recognition motif [IPR034261]", "COMM domain [IPR017920]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPH domain [IPR021097]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium binding and coiled-coil domain-like [IPR012852]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain C2 domain [IPR033884]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carboxypeptidase E, carboxypeptidase domain [IPR034232]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cation/H+ exchanger [IPR006153]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centrosomal CEP44 domain [IPR029157]", "Centrosomal protein of 290kDa, coiled-coil region [IPR032321]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Ceramide kinase, C-terminal domain [IPR045363]", "Chaperone DnaJ, C-terminal [IPR002939]", "Checkpoint kinase 1, catalytic domain [IPR034670]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Citron homology (CNH) domain [IPR001180]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class IX myosin, motor domain [IPR036023]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Copper homeostasis CutC domain [IPR023648]", "Copper type II ascorbate-dependent monooxygenase, C-terminal [IPR024548]", "Copper type II, ascorbate-dependent monooxygenase, N-terminal [IPR000323]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-A, N-terminal APC/C binding region [IPR032447]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic fatty-acid binding [IPR000463]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DET1- and DDB1-associated protein 1, N-terminal [IPR018276]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA mismatch repair protein family, N-terminal [IPR002099]", "DNA mismatch repair protein, S5 domain 2-like [IPR013507]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha, subunit B, N-terminal [IPR013627]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dienelactone hydrolase [IPR002925]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks Large homologue 3, SH3 domain [IPR035763]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homolog subfamily C member 16, TRX domain [IPR043361]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass [IPR039520]", "E3 ubiquitin-protein ligase RNF220, RING finger [IPR040178]", "E3 ubiquitin-protein ligase RNF220, middle domain [IPR031824]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB-1 binding [IPR009232]", "EB1, C-terminal [IPR004953]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF domain [IPR024731]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERCC4 domain [IPR006166]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAK1/PYK2, FERM domain C-lobe [IPR041784]", "FAM3C (ILEI) domain [IPR039475]", "FAM83, N-terminal [IPR012461]", "FAM91, C-terminal domain [IPR028097]", "FAM91, N-terminal domain [IPR028091]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FRAS1-related extracellular matrix protein, N-terminal domain [IPR045658]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Focal adhesion kinase, N-terminal [IPR041390]", "Focal adhesion kinase, targeting (FAT) domain [IPR005189]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Furin-like cysteine-rich domain [IPR006211]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein, beta subunit [IPR001632]", "G2 nidogen/fibulin G2F [IPR006605]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GH15-like domain [IPR011613]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPCR, family 2-like [IPR017981]", "GPR domain [IPR000965]", "GPS motif [IPR000203]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GS domain [IPR003605]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin subgroup [IPR014025]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutaredoxin, eukaryotic/virial [IPR011899]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycosyltransferase subfamily 4-like, N-terminal domain [IPR028098]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Growth factor receptor domain 4 [IPR032778]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HERC2, APC10 domain [IPR037976]", "HERC2, zinc finger, ZZ-type [IPR041987]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HhH-GPD domain [IPR003265]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase complex subunit SAP130, C-terminal domain [IPR031963]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Huntingtin-interacting protein 1, clathrin-binding domain [IPR032422]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain [IPR040464]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Inositol-tetrakisphosphate 1-kinase, N-terminal [IPR041429]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin alpha-2 [IPR013649]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Interferon gamma receptor, poxvirus/mammal [IPR021126]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KOW [IPR005824]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV [IPR000034]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipid transport, open beta-sheet [IPR009454]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "LysM domain [IPR018392]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MABP domain [IPR023341]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MST4, kinase domain [IPR035056]", "MTMR6, PH-GRAM domain [IPR035998]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "Mannosidase Ig/CBM-like domain [IPR041447]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Mediator complex, subunit Med12 [IPR019035]", "Mediator complex, subunit Med12, LCEWAV-domain [IPR021990]", "Mediator complex, subunit Med12, catenin-binding [IPR021989]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NBR1, PB1 domain [IPR034852]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIDO domain [IPR003886]", "NIF system FeS cluster assembly, NifU, N-terminal [IPR002871]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT4, modified RING finger, HC subclass (C4C4-type) [IPR039515]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Na-Ca exchanger/integrin-beta4 [IPR003644]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Nck1, SH2 domain [IPR035882]", "Nck1, SH3 domain 1 [IPR035562]", "Nck1, SH3 domain 2 [IPR035564]", "Nck1, SH3 domain 3 [IPR035565]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuropilin, C-terminal [IPR022579]", "Next to BRCA1, central domain [IPR032350]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Olduvai domain [IPR010630]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PIGA, GPI anchor biosynthesis [IPR013234]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKCBP1, PHD finger [IPR044075]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Palmitoyltransferase, DHHC domain [IPR001594]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C14, p20 domain [IPR001309]", "Peptidase C14, caspase non-catalytic subunit p10 [IPR002138]", "Peptidase C14A, caspase catalytic domain [IPR015917]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C1A, propeptide [IPR012599]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain [IPR045583]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase B alpha, catalytic domain [IPR034676]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM8, RNA recognition motif [IPR033744]", "RED-like, N-terminal [IPR012916]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING finger protein 219, RING finger [IPR035691]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RQC domain [IPR018982]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad4 beta-hairpin domain 1 [IPR018326]", "Rad4 beta-hairpin domain 2 [IPR018327]", "Rad4 beta-hairpin domain 3 [IPR018328]", "Rad4/PNGase transglutaminase-like fold [IPR018325]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "RecQ helicase-like 5 [IPR010716]", "Receptor L-domain [IPR000494]", "Redoxin [IPR013740]", "Regulator of G protein signalling-like domain [IPR015212]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Rhs repeat-associated core [IPR022385]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "RmlD-like substrate binding domain [IPR029903]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rubisco LSMT, substrate-binding domain [IPR015353]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SAS-6 coiled-coil domain [IPR041513]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SEPARIN core domain [IPR030397]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD3, SET domain [IPR044428]", "SETD7, SET domain [IPR044436]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3PXD2, PX domain [IPR037961]", "SH3PXD2B, SH3 domain 1 [IPR035477]", "SH3PXD2B, SH3 domain 2 [IPR035478]", "SH3PXD2B, SH3 domain 3 [IPR035479]", "SH3PXD2B, SH3 domain 4 [IPR035480]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKICH domain [IPR041611]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD2, SET domain [IPR044419]", "SMYD3, SET domain [IPR044420]", "SMYD5, SET domain [IPR044422]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase greatwall, catalytic domain [IPR037638]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Siah interacting protein, N-terminal [IPR015120]", "Sialidase [IPR011040]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm3 [IPR034105]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Sphingomyelin phosphodiesterase, C-terminal domain [IPR045473]", "Spindle assembly abnormal protein 6, N-terminal [IPR032396]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulfotransferase domain [IPR000863]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synembryn [IPR008376]", "Syntaxin 6, N-terminal [IPR015260]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TANK binding kinase 1, ubiquitin-like domain [IPR041087]", "TANK-binding kinase 1, coiled-coil domain 1 [IPR041309]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TGS [IPR004095]", "THADA/TRM732, DUF2428 [IPR019442]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUP1-like enhancer of split [IPR011494]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Teneurin intracellular, N-terminal [IPR009471]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thyroglobulin type-1 [IPR000716]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Tox-GHH domain [IPR028916]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "Trm3/ TARBP1, C-terminal [IPR044748]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubby, C-terminal [IPR000007]", "Tubby, N-terminal [IPR005398]", "Tuberin, N-terminal [IPR024584]", "Tuberin-type domain [IPR018515]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Lyn, SH2 domain [IPR035852]", "Tyrosine-protein kinase Lyn, SH3 domain [IPR035748]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glucuronate decarboxylase N-terminal [IPR021761]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UMA domain [IPR023340]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS9 domain [IPR003123]", "Vacuolar protein 14, C-terminal Fig4-binding domain [IPR021841]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vitellinogen, open beta-sheet [IPR015255]", "Vitellogenin, N-terminal [IPR001747]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZMYND8/11, PWWP domain [IPR035505]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, A20-type [IPR002653]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA decapping enzyme 2 , NUDIX hydrolase domain [IPR044099]", "mRNA decapping protein 2, Box A domain [IPR007722]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p115RhoGEF, RGS domain [IPR037887]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNA/rRNA methyltransferase, SpoU type [IPR001537]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APLP2", "APMAP", "APOB", "APOBEC3C", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMCX3", "ARMT1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7A", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAP18", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCL10", "BCOR", "BCS1L", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPHL", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRIX1", "BROX", "BSG", "BTF3", "BTN2A1", "BUB1B", "BZW1", "BZW2", "C11orf58", "C1orf35", "C2CD5", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALM3", "CALU", "CAMK2G", "CAND1", "CAND2", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CBL", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC25", "CCNA2", "CCNB1", "CCNB2", "CD276", "CD2AP", "CD2BP2", "CD46", "CD47", "CDC20", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CDKN2AIP", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CEP44", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLIC1", "CLINT1", "CLIP1", "CLPB", "CLPX", "CLTC", "CLUH", "CMBL", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNPY2", "COA3", "COIL", "COLEC12", "COMMD4", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPE", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CRKL", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTC", "CWF19L1", "CXADR", "CYB5B", "CYB5R3", "CYFIP1", "CYFIP2", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCP2", "DCTN1", "DCUN1D4", "DDA1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DGCR8", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERLIN2", "ERMP1", "ERP29", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM208A", "FAM3C", "FAM49B", "FAM83D", "FAM91A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FOXC1", "FOXRED1", "FREM2", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOPC", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS3", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "IAH1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS12", "INTS14", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRGQ", "IRS4", "ISCU", "ISOC1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPK1", "IVD", "IWS1", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIRREL1", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMB1", "LAMC1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8E", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAP2K4", "MAP4K5", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED12", "MEPCE", "METAP2", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD8", "MIA3", "MICU1", "MICU2", "MID1", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCBP1", "NCK1", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHLRC2", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NTHL1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDXK", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLAA", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP2", "PXN", "PYCR1", "PYCR2", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABGAP1", "RAC1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "RECQL5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOX2", "RIPK1", "RNASEH2A", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRP12", "RSF1", "RTFDC1", "RTN3", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SASS6", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SETD1A", "SETD3", "SETD7", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC2A1", "SLC2A4", "SLC38A2", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPECC1", "SPECC1L", "SPEN", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STOML2", "STRBP", "STRN", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX10", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLCD1", "TLK2", "TLN1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM97", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSR1", "TST", "TSTA3", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "UXS1", "VAC14", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VCP", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS29", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YKT6", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF346", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZRANB2", "ZYX"], "leading_proteins": ["ABCD4", "ACACA", "ACACB", "ACTN4", "ADGRE5", "AKR1A1", "AKR7A2", "AKT1", "AKT2", "ALG2", "ANK3", "ANKFY1", "ANKS1A", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP2A2", "AP2B1", "AP3D1", "AP3S1", "ARHGEF1", "ARIH2", "ASH2L", "ATAD5", "BAIAP2", "BRD7", "BRD9", "BTN2A1", "CALU", "CAMK2G", "CBL", "CCNB2", "CD276", "CDC20", "CDK4", "CDK9", "CETN2", "CHD3", "CHERP", "CHORDC1", "CIRBP", "CMTR1", "CNDP2", "CNOT4", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "CORO1C", "CORO7", "CPNE1", "CPSF4", "CSE1L", "CSNK1A1", "CSRP2", "CTPS1", "CTPS2", "CUL1", "CUL2", "CUL3", "CUL4B", "CYFIP1", "CYFIP2", "DDI2", "DHX15", "DHX16", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DIAPH1", "DIAPH3", "DNA2", "DNAJA1", "DNAJA2", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNM2", "DNMT1", "DRG2", "DSC1", "DSC3", "DSP", "DUSP3", "EARS2", "EEF1A2", "EEF1D", "EIF3A", "EIF3B", "EIF3E", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4G1", "EIF4G3", "ELOA", "EMC8", "EPB41", "EPB41L2", "EPHA7", "EPRS", "ERAP1", "ERCC3", "ESYT2", "EWSR1", "EXOC2", "FH", "FHOD1", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP9", "FLII", "FMR1", "FUS", "GALNT2", "GGA2", "GINS2", "GNL1", "GNL3", "GNL3L", "GOPC", "GSTA4", "HBS1L", "HDDC2", "HECTD3", "HERC2", "HIP1", "HLA-A", "HLA-C", "HMGB1", "HMGB2", "HMGB3", "HNRNPD", "HNRNPF", "HNRNPH2", "HNRNPL", "HNRNPUL1", "IDH2", "IDH3A", "IMPDH1", "INA", "INTS14", "IPO11", "IPO4", "IPO5", "IPO8", "IPO9", "IRS4", "ITCH", "IWS1", "KARS", "KCTD5", "KEAP1", "KHSRP", "KIF18B", "KIF20B", "KIF23", "KIFC1", "LARP4", "LARP7", "LBR", "LSG1", "LSM14B", "LTN1", "LYPLAL1", "MCCC1", "MCM4", "MCM7", "MDN1", "METAP2", "MID1", "MOV10", "MPP2", "MPP6", "MRPL39", "MTA1", "MTA2", "MTOR", "MTPAP", "MTX1", "MYH10", "MYH14", "MYL6", "MYO1B", "MYO6", "NAA40", "NEDD4L", "NFATC2IP", "NLN", "NME2", "NOA1", "NOB1", "NOM1", "NONO", "NPEPPS", "NPLOC4", "NRBP1", "NRDC", "NSD2", "NUCB1", "NUCB2", "NUDCD2", "OLA1", "OPA1", "OSBP", "OTUD7B", "PA2G4", "PANK4", "PBRM1", "PC", "PCCA", "PDCD4", "PDLIM3", "PFKM", "PGM2", "PI4KB", "PICALM", "PIN1", "PKN2", "PMS1", "POLA2", "POLR1B", "PPP6C", "PQBP1", "PRDX3", "PRDX4", "PRDX6", "PRKACA", "PRKCD", "PRKRA", "PROCR", "PSMA1", "PSMA6", "PSMC1", "PSMC3", "PSMC5", "PSMC6", "PSMD11", "PSMD12", "PSMD13", "PSMD6", "PSMD7", "PTGR1", "PTK2", "PUF60", "RBM3", "RBM4", "RBMX", "RCN1", "RCN2", "RIOX2", "RIPK1", "RNF2", "RNF220", "RPF2", "RPL27A", "RPL7", "RPRD1A", "RPRD1B", "RPS2", "RPS20", "SAMHD1", "SARS2", "SCAF11", "SCAF4", "SDF4", "SEC16A", "SEC24B", "SEPT2", "SEPT9", "SF1", "SFPQ", "SH3PXD2B", "SHMT2", "SKP1", "SMARCAD1", "SMARCE1", "SMG5", "SMYD3", "SPATA5", "SPTAN1", "SPTLC2", "SQSTM1", "SRPK2", "SSRP1", "STAM", "STARD3", "STARD7", "STAT3", "SUGT1", "SUPT16H", "SYNCRIP", "SYNJ2BP", "TAF15", "TARS", "TARS2", "TBC1D4", "TFG", "THOC3", "TIAL1", "TIMM50", "TJP2", "TLCD1", "TLK2", "TNPO1", "TNPO3", "TOM1", "TOX4", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRMT11", "TRRAP", "TSR1", "TSTA3", "TUBB", "TUBB4A", "TUFM", "U2SURP", "UBE3C", "UBR4", "UBR5", "UBTF", "UNC119B", "UQCRC1", "USP11", "USP24", "USP28", "USP33", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTRN", "WDHD1", "XPNPEP1", "XPNPEP3", "XPO1", "XPO7", "XPOT", "YTHDF3", "ZC3HAV1", "ZCCHC3"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f6bd5b9f0e60fef9063a9b06df6e43814a13f72a --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c161189aacd93876df4a3fe61120c8775ac1d887 --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d0944ee519a7e9286dd187a36eeb1058bc5c810e14fc540f2a46406fa998a4fd +size 191827 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..ba1373b3955ed8234d30f3ee235a9420cff6c8fc --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "26S proteasome regulatory subunit P45-like [IPR005937]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..abff4559c2dfd22c54a1b8c148a759e2febc193c --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8aba5aaaf6394e0c82dd040f437f7e7a5e91ec27db75dc20fa3fb4fae2e04a44 +size 128302 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..34047e90ef4b79142b025bc9da6a74e5c9262429 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:305fa373e369d34e3aaf2371c295773ee7f5d6045008a94537cc97b6fed55794 +size 142142 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..821a3bcdbf095116c5f8362bb7a4665ab87a8c66 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8eebaf13f2b752c1f42aee279dbfb1e9a18e7bb02ac3cddbabb3147285364715 +size 235869 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4929c487a7d054ceb51ac31422a5aba9955af42e --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome B-type subunit [IPR023333] 3 7 2.4950966221000086 0.0125922836245955 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 9.130642966886304e-06 6.123874455167476e-05 3.1648689494321087e-05 0.0004978290871657 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 2 5 2.129841148385085 0.0331847302262424 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.000647621121882 0.0022711903824547 0.0006213832587155 0.004805053921831 +Proteasome, subunit alpha/beta [IPR001353] 7 14 2.1179158275973347 0.034182196912375 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 1.0 5.941460259222129e-05 0.0003895651505262 0.000402479144766 5.510223713365821e-05 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..83ac50784b039e088cdc6fb899248444090f6ab9 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 2369, + "title": "Average number of proteins per term", + "value": 1.276910088644998 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0e39f3e05879b252510e9763785448b2fe2ec06b --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f7c65befffc7baebb2fe61fb97cf412ec1c1a1ee --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,92 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome B-type subunit [IPR023333] 0.8792083465608126 2.4950966221000086 0.0125922836245955 0.9999999999999084 0.2802937643197614 7 P28074,P28070,P49721 3 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.862951099035985 2.1298411483850854 0.0331847302262424 1.0 0.2802937643197614 5 P55786,Q9NZ08 2 +Proteasome, subunit alpha/beta [IPR001353] 0.7254770875866369 2.1179158275973347 0.034182196912375 1.0 0.2802937643197614 14 P25786,P28070,P49721,Q99436,P20618,P28074,P60900 7 +Protein arginine N-methyltransferase [IPR025799] 0.8107930240210603 1.9132786910305175 0.055712384187879 1.0 0.2908309890679442 5 Q99873,O60678,Q86X55,Q6P2P2 4 +Desmosomal cadherin [IPR009122] 0.8418410034985202 1.890679626954825 0.0586671236483784 1.0 0.2933232130572115 4 Q14574 1 +Aminopeptidase N-type [IPR034016] 0.951002959552776 1.8410551952754004 0.0656134705964281 1.0 0.3059809288246818 3 P55786,Q9NZ08 2 +Glutathione Transferase family [IPR040079] 0.6630917925799047 1.787485928367341 0.0738589844440937 1.0 0.3148804062325481 9 O15217 1 +TAF15/EWS/TLS family [IPR034870] 0.9125287734297886 1.696803586173821 0.0897338005333061 1.0 0.3392466597650361 3 Q92804,P35637 2 +Nucleosome assembly protein (NAP) [IPR002164] 0.8967444919434371 1.637276330294239 0.10157274430785 1.0 0.3572247163489281 3 P55209,Q99733 2 +SCAMP [IPR007273] 0.6848614375103426 1.2405916077731287 0.2147566537391141 1.0 0.5154136020008929 4 O15127,Q969E2 2 +Peptidase M3A/M3B [IPR045090] 0.7690006105895117 1.1524713017502055 0.2491274559957164 1.0 0.5576784588660124 3 Q9BYT8 1 +Initiation factor 2B-related [IPR000649] 0.65931927612808 1.1339389610391255 0.2568201527509128 1.0 0.5680107910601426 4 Q9UI10,P49770 2 +Proteasome alpha-type subunit [IPR023332] 0.5762767645209298 1.1285825747528846 0.2590739648902185 1.0 0.5693378690398215 7 P25786,P60900 2 +Mpv17/PMP22 [IPR007248] 0.9878369493754112 1.1201480514048654 0.2626506769431218 1.0 0.5724061402976623 2 P39210 1 +Importin beta family [IPR040122] 0.6550251820317181 1.1160512188288652 0.2644002111027017 1.0 0.5737354758239016 4 O00410,Q92973 2 +Nucleobindin [IPR040250] 0.981591058514136 1.098859975401454 0.2718291470428255 1.0 0.5817192857673475 2 P80303 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.9697567389875102 1.0586724327384218 0.2897489867781651 1.0 0.6021187277872571 2 Q14739 1 +Cyclin [IPR039361] 0.7423729097555287 1.052155119969422 0.292728386570487 1.0 0.6051252598477171 3 O95067 1 +Nonaspanin (TM9SF) [IPR004240] 0.728378822755656 0.99981286123574 0.317401080541698 1.0 0.6339992915710646 3 Q92544,Q99805 2 +Kinesin-like protein [IPR027640] 0.4968399737801841 0.9526066254299832 0.3407894190597451 1.0 0.6571788394067698 9 Q86Y91,Q96Q89,Q02241 3 +DNA2/NAM7-like helicase [IPR045055] 0.5874115760106483 0.952321292814545 0.3409340623178218 1.0 0.6571788394067698 5 Q9HCE1,P51530 2 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.9309664694280086 0.9286243310618104 0.3530838079415046 1.0 0.6691644328107396 2 P48735 1 +Protein of unknown function DUF3512 [IPR021900] 0.9299802761341278 0.9253578523619452 0.3547797949839064 1.0 0.6700549719666895 2 Q9NPI1 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9188034188034238 0.8884992647627431 0.374272251158974 1.0 0.6894642013962747 2 O60830 1 +Serine hydroxymethyltransferase [IPR001085] 0.916502301117689 0.8809492034935978 0.3783453142737589 1.0 0.694806239933748 2 P34897 1 +KH domain-containing BBP-like [IPR045071] 0.6793817823084413 0.8197690553177366 0.4123477748998161 1.0 0.7244919806202582 3 Q07666,Q96PU8 2 +ER lumen protein retaining receptor [IPR000133] 0.8846153846153925 0.7778687949463922 0.4366463661923407 1.0 0.7436486279724338 2 O43731 1 +Prenyltransferase subunit beta [IPR045089] 0.868507560815263 0.727050566921206 0.4671949794144994 1.0 0.768627773360573 2 P49356 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.865220249835646 0.7167970904818465 0.4734993072495488 1.0 0.7725343380676178 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.865220249835646 0.7167970904818465 0.4734993072495488 1.0 0.7725343380676178 2 Q93050 1 +Calponin/LIMCH1 [IPR001997] 0.848783694937537 0.6661815685254835 0.5052950524695046 1.0 0.8003715761504514 2 Q15417 1 +Mini-chromosome maintenance protein [IPR031327] 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 0.8003715761504514 6 P33991,P33993 2 +Cytoplasmic FMR1-interacting [IPR008081] 0.841880341880338 0.6452676867912633 0.51875372911105 1.0 0.8081064690028741 2 Q7L576 1 +CTP synthase [IPR004468] 0.8405654174884915 0.6413085162636741 0.5213222572193084 1.0 0.808783514965646 2 P17812 1 +Surfeit locus 1/4 [IPR045214] 0.8379355687047967 0.6334141891733138 0.526463201476641 1.0 0.8119735685008773 2 Q15526 1 +Small GTPase Rho [IPR003578] 0.506353476822318 0.6163289335422946 0.5376774465018612 1.0 0.8171307314749644 5 P60953,P61586 2 +Peptidase M20 [IPR002933] 0.824786324786321 0.5944409186317727 0.5522172472694504 1.0 0.824431654882991 2 Q96KP4 1 +E3 ubiquitin-protein ligase, SMURF1 type [IPR024928] 0.8238001314924557 0.5915526118989692 0.5541502145339201 1.0 0.8246117199942568 2 Q96PU5 1 +Chaperone DnaJ [IPR012724] 0.8218277449046674 0.5857910087580522 0.5580159666216178 1.0 0.8265164830458487 2 O60884 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.8218277449046674 0.5857910087580522 0.5580159666216178 1.0 0.8265164830458487 2 O60884 1 +Glutamyl/glutaminyl-tRNA synthetase [IPR000924] 0.6113120683985402 0.5836398360828332 0.55946265285052 1.0 0.8265164830458487 3 Q5JPH6,P07814 2 +Ribosomal protein L4/L1e [IPR002136] 0.8191978961209683 0.5781403593517079 0.5631693606886736 1.0 0.8281491095415691 2 Q9BYD3 1 +YTH domain containing protein [IPR045168] 0.81558185404339 0.5676804553613172 0.5702519651182529 1.0 0.832364082171991 2 Q7Z739 1 +Transcription factor STAT [IPR001217] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.8541386966434021 2 P40763 1 +Mitochondrial carrier UCP-like [IPR002030] 0.7915844838921722 0.5001245030966806 0.6169874137339977 1.0 0.8568566500859943 2 Q9H2D1 1 +HnRNP R/Q splicing factor [IPR006535] 0.7879684418146016 0.4902418868647853 0.6239627438496416 1.0 0.8603890636792404 2 O60506 1 +Cullin [IPR045093] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.8656630901191597 5 Q13616,Q13617,Q13618,Q13620 4 +S-phase kinase-associated protein 1-like [IPR001232] 0.7692307692307724 0.4403832245877427 0.6596595727453745 1.0 0.8740120401754989 2 P63208 1 +Initiation factor 4G [IPR045208] 0.558040118382105 0.4178164476042438 0.6760813244647101 1.0 0.8829309027877057 3 O43432,Q04637 2 +Smooth muscle protein/calponin [IPR003096] 0.5367484118032531 0.3580400250487845 0.7203133606839669 1.0 0.9028689690266232 3 Q15417 1 +Mesoderm induction early response protein/metastasis-associated protein [IPR040138] 0.7347140039447667 0.3550257489736944 0.7225703012418911 1.0 0.9033082024496254 2 O94776 1 +Beta tubulin [IPR002453] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 0.9322260423465984 6 P04350,P07437 2 +Tubulin [IPR000217] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 0.9322260423465984 6 P04350,P07437 2 +Exportin 4/7-like [IPR044189] 0.6978961209730442 0.2744227795107482 0.7837597391866158 1.0 0.9325526119953214 2 Q9C0E2 1 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.4798478514475378 0.2212401121639516 0.8249054780112719 1.0 0.9407979369924104 3 Q06787 1 +Exportin-1/5 [IPR045065] 0.6656804733727775 0.2136774824086904 0.8307985722281714 1.0 0.9407979369924104 2 O14980 1 +Coatomer gamma subunit [IPR017106] 0.6646942800788944 0.2119686685772241 0.8321314777528488 1.0 0.9407979369924104 2 Q9Y678 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.463763857895957 0.1893498096983764 0.849818658851609 1.0 0.9407979369924104 3 P12236 1 +Dynamin [IPR022812] 0.4557711279184346 0.1746833126255487 0.8613284807533532 1.0 0.9420006993033472 3 P50570,O60313 2 +26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134] 0.6406969099276723 0.1732009407933783 0.8624934841716205 1.0 0.9420006993033472 2 Q9BT78 1 +26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585] 0.6278763971071606 0.1547108986931106 0.8770492375375807 1.0 0.9427085497851764 2 Q15008 1 +Aminoacyl-tRNA synthetase, class Ic [IPR002305] 0.4360950830977109 0.1419590018212687 0.8871123894509572 1.0 0.9466528155897826 3 Q9Y2Z4 1 +CPSF6/7 family [IPR034772] 0.6055226824457525 0.1261374119339227 0.8996231535250148 1.0 0.9517732208513354 2 Q16630 1 +26S proteasome regulatory subunit P45-like [IPR005937] 0.3291639236339724 0.1102032130362119 0.9122482141624756 1.0 0.9534769492751876 6 P62195,P62191,P43686,P62333,P17980 5 +Nucleoside diphosphate kinase [IPR001564] 0.4119312231343535 0.1083149391363728 0.913745872618294 1.0 0.9535964635386516 3 P22392 1 +NudC family [IPR037898] 0.5831689677843439 0.1020912236180992 0.918684267154579 1.0 0.9570637769961292 2 Q8WVJ2 1 +Histidine phosphatase superfamily, clade-1 [IPR013078] 0.3988819467280524 0.0930645610391356 0.9258522714050532 1.0 0.9611498821027918 3 P18669,Q96HS1 2 +Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081] 0.3962512331469913 0.0902296704139933 0.9281047069036958 1.0 0.9626445055406548 3 Q92688,P39687 2 +Inosine-5'-monophosphate dehydrogenase [IPR005990] 0.5588428665351666 0.0807702109593559 0.9356246988547784 1.0 0.9679017081165806 2 P20839 1 +Threonine-tRNA ligase, class IIa [IPR002320] 0.5568704799473929 0.0792502819934198 0.9368335510770288 1.0 0.9683065804980284 2 Q9BW92 1 +Small GTPase superfamily, ARF type [IPR024156] 0.3701310291299011 0.0662139222757561 0.9472075127267274 1.0 0.9777492800216196 3 P18085 1 +Ribosomal protein S5 [IPR000851] 0.5335305719921 0.0634658723119335 0.9493955343867246 1.0 0.9791545585381588 2 P15880 1 +DNA-directed RNA polymerase, subunit 2 [IPR015712] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 0.9820588276404628 2 Q9H9Y6 1 +Aldo-keto reductase [IPR020471] 0.5190664036817758 0.0555747906030647 0.955680547643103 1.0 0.982215712523432 2 P14550 1 +ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 0.9823103070887252 3 P08237 1 +ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 0.9823103070887252 3 P08237 1 +ATP-dependent 6-phosphofructokinase [IPR022953] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 0.9823103070887252 3 P08237 1 +Cell-cycle alteration and expression-elevated protein in tumour [IPR032337] 0.3406774087471246 0.0472474944923395 0.9623159746325538 1.0 0.9848159752385902 3 Q96P16,Q9NQG5 2 +Fumarate lyase family [IPR000362] 0.4970414201183319 0.0459911079456646 0.963317337242958 1.0 0.9848159752385902 2 P07954 1 +Coronin [IPR015505] 0.3232489312726108 0.0394205484112153 0.968555097378214 1.0 0.9884404051456006 3 P57737,Q9ULV4 2 +Oligosaccharyl transferase, STT3 subunit [IPR003674] 0.4667981591058414 0.0368230919634998 0.9706260618080532 1.0 0.9889948991067864 2 P46977 1 +Ribosomal protein S15 [IPR000589] 0.4283366206443078 0.0300930605982503 0.9759928350666304 1.0 0.991622885533637 2 P82914 1 +Microtubule associated protein 1 [IPR026074] 0.4263642340565322 0.0298590274125525 0.9761794826556188 1.0 0.991622885533637 2 Q66K74 1 +Inorganic pyrophosphatase [IPR008162] 0.4220907297830341 0.0293819913825809 0.976559935398878 1.0 0.991622885533637 2 Q9H2U2 1 +HnRNP-L/PTB [IPR006536] 0.272875657538022 0.0293524559108759 0.976583491135924 1.0 0.991622885533637 4 P14866 1 +Ribosome biogenesis protein Bms1/Tsr1 [IPR039761] 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 0.991622885533637 2 Q2NL82 1 +Septin [IPR016491] 0.2847747451496275 0.0288647189350643 0.9769724841011012 1.0 0.991622885533637 3 Q15019,Q9UHD8 2 +Inositol monophosphatase-like [IPR000760] 0.2938856015779102 0.0250165001392838 0.9800418025193376 1.0 0.9926278620987308 2 Q9NX62 1 +Ribosomal protein L7/L30 [IPR039699] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 0.9926278620987308 2 P18124 1 +Ribosomal protein L7, eukaryotic [IPR005998] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 0.9926278620987308 2 P18124 1 +La domain containing protein [IPR045180] 0.2436904992055359 0.004445398076708 0.9964530971900336 1.0 1.0 5 Q4G0J3,Q71RC2 2 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b565ea5befa518aa7e32bd28f2f8a72aaaa0b3cd --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "14kDa phosphohistidine phosphatase [IPR028441]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5'-deoxynucleotidase YfbR/HDDC2 [IPR039356]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ABI family [IPR028457]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor 6 [IPR041838]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "ALG11 mannosyltransferase [IPR038013]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase subunit ATP5MJ, mitochondrial [IPR012574]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Abl interactor 1 [IPR028456]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acid sphingomyelinase-like phosphodiesterase, predicted [IPR017064]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-histidine N-methyltransferase SETD3 [IPR025785]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein Cbl [IPR024162]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenomatous polyposis coli (APC) family [IPR026818]", "Adenomatous polyposis coli [IPR026836]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl cyclase-associated protein CAP2 [IPR028418]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Anion exchange protein 2 [IPR002978]", "Anion exchange protein [IPR001717]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Ankyrin repeat and SAM domain-containing protein 1A [IPR033637]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator BAX [IPR026304]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Apyrase [IPR009283]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arv1 protein [IPR007290]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "B-cell lymphoma/leukemia 10/E10 [IPR033238]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "BTB-kelch protein [IPR017096]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bromodomain-containing protein 8 [IPR038002]", "Bud22/Serum response factor-binding protein 1 [IPR037393]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 4 [IPR039780]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD166 antigen [IPR039810]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDC45 family [IPR003874]", "CDC50/LEM3 family [IPR005045]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 4 [IPR037356]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF complex subunit CPSF4-like [IPR045348]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cancer susceptibility candidate 4 [IPR026141]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carboxymethylenebutenolidase homolog [IPR042946]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Caspase-2 [IPR035702]", "Caspase-3/7 [IPR015471]", "Cat eye syndrome critical region protein 2 [IPR029614]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cation/H+ exchanger, CPA1 family [IPR018422]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle control protein 50A [IPR030351]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Cellular repressor of E1A-stimulated genes (CREG) [IPR014631]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-M [IPR020987]", "Centromere protein I [IPR012485]", "Centrosomal protein of 170kDa [IPR026644]", "Centrosomal protein of 290kDa [IPR026201]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceramide glucosyltransferase [IPR025993]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin modification-related protein Eaf6 [IPR015418]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Copper homeostasis protein CutC [IPR005627]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoplasmic protein NCK [IPR017304]", "Cytoplasmic protein NCK1 [IPR028526]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DET1- and DDB1-associated protein 1 [IPR033575]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutL/Mlh/Pms [IPR038973]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase alpha, subunit B [IPR016722]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad4 [IPR004583]", "DNA repair protein Rad4, subgroup [IPR018026]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair protein XPF [IPR006167]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "DUF5568 family [IPR040419]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxyribonuclease II [IPR004947]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [IPR039485]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dymeclin [IPR019142]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase CBX4 [IPR043531]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase HECTD3 [IPR042469]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF14 [IPR031128]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand calcium-binding domain-containing protein 14 [IPR042352]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongator complex protein 4 [IPR008728]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Endonuclease III-like protein 1 [IPR030841]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelial protein C receptor [IPR015669]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Ephrin receptor type-A /type-B [IPR016257]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Etoposide-induced 2.4 [IPR009890]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "F-box-like/WD repeat-containing protein Ebi-like [IPR045183]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM177 family [IPR028260]", "FAM3 family [IPR039220]", "FAM91 [IPR039199]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GDP-mannose 4,6-dehydratase [IPR006368]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf1 [IPR005339]", "GINS complex, subunit Psf3 [IPR010492]", "GOLM1/CASC4 family [IPR026139]", "GPCR, family 2, ADGRE2/ADGRE5 [IPR003056]", "GPCR, family 2, secretin-like [IPR000832]", "GPI mannosyltransferase [IPR005599]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gdt1 family [IPR001727]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit beta [IPR026873]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glu-tRNAGln amidotransferase C subunit [IPR003837]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose transporter, type 4 (GLUT4) [IPR002441]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, alpha class [IPR003080]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 47 [IPR001382]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycoside hydrolase, family 79 [IPR005199]", "Glycosyl transferase, family 13 [IPR004139]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi membrane protein 1 [IPR026143]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgi-associated PDZ and coiled-coil motif-containing protein [IPR038879]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Gtr1/RagA G protein [IPR006762]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "H/ACA ribonucleoprotein complex, subunit Nop10 [IPR007264]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAUS augmin-like complex subunit 2 [IPR028346]", "HAUS augmin-like complex subunit 2, metazoa [IPR026242]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone chaperone ASF1-like [IPR006818]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex subunit SAP130 [IPR024137]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase EHMT2 [IPR038034]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "Histone-lysine N-methyltransferase, SET [IPR017155]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Huntingtin-interacting protein 1 [IPR030554]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "ISC system FeS cluster assembly, IscU scaffold [IPR011339]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B alpha/beta/delta [IPR011559]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Inositol-tetrakisphosphate 1-kinase [IPR008656]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 10 [IPR026164]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 2 [IPR029321]", "Integrator complex subunit 2, metazoa [IPR026236]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 9 [IPR027074]", "Integrin alpha chain [IPR000413]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon gamma receptor alpha subunit [IPR008355]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Isoamyl acetate-hydrolyzing esterase Iah1-like [IPR045136]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Janus [IPR007702]", "Jlp2/Ccd25 [IPR039730]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KRR1 interacting protein 1 [IPR018034]", "Kelch-like ECH-associated protein 1 [IPR030563]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20B [IPR028828]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper putative tumor suppressor [IPR045329]", "Leucine zipper putative tumour suppressor 2 [IPR028597]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte elastase inhibitor (serpin B1) [IPR015557]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "LicD family [IPR007074]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "LysM and putative peptidoglycan-binding domain-containing protein 1-4 [IPR045030]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase phosphoprotein 6 [IPR019324]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MORF4 family-associated protein 1 [IPR029254]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannosyltransferase ALG2 [IPR027054]", "Mediator complex, subunit Med16 [IPR021665]", "Mediator complex, subunit Med17 [IPR019313]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membralin [IPR019144]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane cofactor protein CD46 [IPR017341]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthioribose-1-phosphate isomerase [IPR005251]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microprocessor complex subunit DGCR8 [IPR040375]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitogen-activated protein (MAP) kinase kinase kinase kinase [IPR021160]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Multivesicular body subunit 12 [IPR018798]", "Multivesicular body subunit 12A [IPR040335]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na+/H+ exchanger [IPR004709]", "Na+/H+ exchanger, isoform 6/7/9 [IPR002090]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Next to BRCA1 gene 1 protein [IPR033513]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar and spindle-associated protein 1 [IPR026756]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "ORC ubiquitin ligase 1 [IPR039209]", "Occludin [IPR002958]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Palmitoyltransferase ZDHHC13 [IPR030290]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Paxillin [IPR001904]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C14 family [IPR002398]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C50, separase [IPR005314]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase [IPR000720]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3 [IPR039507]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylase kinase alpha/beta subunit [IPR008734]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphoserine phosphatase [IPR004469]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polycomb protein EED [IPR037352]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Pre-rRNA-processing protein TSR2 [IPR019398]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable methyltransferase TARBP1 [IPR025806]", "Probable methyltransferase Trm3/TARBP1 [IPR045330]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline racemase family [IPR008794]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase 3 [IPR039839]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM234 [IPR045232]", "Protein FAM3C [IPR039219]", "Protein FRG1 [IPR010414]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF3512 [IPR021900]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein of unknown function DUF842, eukaryotic [IPR008560]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA methyltransferase [IPR003750]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-binding protein Nova-2 [IPR033087]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab35 [IPR041815]", "Rab39 [IPR041818]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab9 [IPR041824]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "RagC/D [IPR039400]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "Ral GTPase-activating protein subunit beta [IPR039930]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Renin receptor-like [IPR012493]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulophagy receptor 1/3 [IPR043384]", "Reticulophagy regulator 3 [IPR033361]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAP30-binding protein [IPR012479]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3 and PX domain-containing protein 2B [IPR030512]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sdc1/DPY30 [IPR037856]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Ser/Thr protein kinase, TGFB receptor [IPR000333]", "Serine hydroxymethyltransferase [IPR001085]", "Serine incorporator 1/3 [IPR029557]", "Serine incorporator/TMS membrane protein [IPR005016]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase RAC alpha [IPR039027]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase TOUSLED-like 2 [IPR027086]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialidase family [IPR026856]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sla2 family [IPR030224]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 1/Shy1 [IPR002994]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptic vesicle protein SV2 [IPR022308]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntaxin-3 [IPR031186]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TCF25/Rqc1 [IPR006994]", "TE2IP/Rap1 [IPR039595]", "TEL2-interacting protein 1 [IPR016441]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM206 protein [IPR029366]", "TMEM33/Pom33 family [IPR005344]", "TMEM9/TMEM9B [IPR008853]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "Target of Myb protein 1 [IPR014645]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Teneurin-3/4 [IPR027691]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "The WD repeat Cdc20/Fizzy family [IPR033010]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulator TACO1-like [IPR002876]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Translocon-associated protein subunit gamma [IPR009779]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tuberin [IPR003913]", "Tuberin/Ral GTPase-activating protein subunit alpha [IPR027107]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine protein kinase, EGF/ERB/XmrK receptor [IPR016245]", "Tyrosine-protein kinase, insulin-like receptor [IPR016246]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "U6 snRNA-associated Sm-like protein Lsm3 [IPR040002]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronic acid decarboxylase [IPR044516]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised protein family UPF0687 [IPR026794]", "Uncharacterised protein family, TMEM59 [IPR022065]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Unconventional myosin-IXb [IPR028557]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Vacuole morphology and inheritance protein 14 [IPR026825]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Very low-density lipoprotein receptor [IPR032931]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat HIR1 [IPR031120]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 73 [IPR042795]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YIP1 family member 3 [IPR026637]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase, Trm7 [IPR028590]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote [IPR025763]", "tRNA (guanine-N-7) methyltransferase, Trmb type [IPR003358]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA pseudouridine synthase B family [IPR004802]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANKLE2", "ANKS1A", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFIP1", "ARHGDIA", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L13", "BCLAF1", "BDH2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BRAT1", "BRCA1", "BRD7", "BRD8", "BRD9", "BRI3BP", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BUD31", "BYSL", "C11orf58", "C14orf2", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX3", "CBX4", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC25", "CCDC47", "CCDC6", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK5RAP3", "CDKAL1", "CDS2", "CDV3", "CDYL", "CEBPZ", "CECR2", "CELF2", "CENPI", "CENPM", "CEP170", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHERP", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXorf56", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYM", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EFCAB14", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM120B", "FAM136A", "FAM162A", "FAM177A1", "FAM213A", "FAM234B", "FAM3C", "FAM49B", "FAM50A", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GCAT", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMDS", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLM2", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDHD2", "HEATR1", "HEBP1", "HECTD1", "HECTD3", "HELZ", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO4", "IPO5", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDELR3", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMF2", "LNPEP", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSG1", "LSM12", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYSMD3", "LZIC", "LZTFL1", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAP1B", "MAP1S", "MAP4", "MAP4K5", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17", "MPV17L2", "MRE11", "MRFAP1", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MVB12A", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCLN", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NEU1", "NF1", "NFS1", "NHP2", "NIP7", "NIPBL", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUSAP1", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAK2", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PBDC1", "PBRM1", "PC", "PCBD1", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLEC", "PLIN3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPH", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUDP", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABGAP1", "RABGGTB", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM5", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETREG3", "REXO4", "RFC1", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF40", "RNMT", "RNPEP", "ROCK2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG5", "SMPD4", "SMPDL3A", "SMS", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1L", "SPOUT1", "SPPL2A", "SPR", "SPTBN1", "SQLE", "SRFBP1", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRBP", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX3", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF1", "SURF4", "SURF6", "SV2A", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TACO1", "TAF15", 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"TRAP1", "TRAPPC4", "TRAPPC5", "TRIM28", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSR2", "TST", "TSTA3", "TTC19", "TTC26", "TTC37", "TTC38", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBR4", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRQ", "URB1", "UROD", "USMG5", "USP10", "USP14", "USP24", "USP39", "USP5", "USP9X", "UTP11", "UTP14A", "UTP18", "UTP3", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS26A", "VPS29", 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sha256:5ccd1a6c75bbcca3c632a9c83a735cde082d4c4a062981fe3b14f62c21bb1307 +size 154419 diff --git a/interpro_homologous_superfamily/consensus.joblib b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..7cce592500b9477a2535c4283b2cd36751a94b4d --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9b2ad52f19a373cb4ce2a4a69d6582da2e883144ca00231489cb3a50be04c707 +size 109707 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bd940758b15add8816ee13adbc73542e2905a9a0 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Rudiment single hybrid motif [IPR011054] 4 6 2.4729387560106573 0.0134007105673723 4.592233009708738 5.890776699029126 -1.9937427767755864 0.0922188338858135 0.9210261605540432 0.311919174620445 1.449370829194519 0.2206040317774329 1.0 1.0 0.0012314372892181 3.67216320769966e-08 1.2803308876244608e-06 +Pre-ATP-grasp domain superfamily [IPR016185] 4 8 2.3470079680493137 0.018924850064274 4.890776699029126 7.871359223300971 -2.05233613048585 0.1042945789544412 1.0544461476490947 0.3821948584080789 1.4268170383063945 0.2366644135195186 1.0 1.0 0.0052264902137193 4.3261655979057245e-06 0.0001335078390794 +FAD/NAD(P)-binding domain superfamily [IPR036188] 2 18 2.225605565190574 0.0260406131043737 5.128640776699029 19.483009708737864 1.1388517428876976 0.3148047818604211 2.42568278788952 1.8971625900564304 0.9268276914308484 0.2996934003616133 0.0152147819093601 0.000895633126088 0.0054550629616739 0.060196873958637 0.0343234064132246 +Peptidase M4/M1, CTD superfamily [IPR027268] 2 5 2.129841148385085 0.0331847302262424 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 0.0008300469730069 0.0029026051361948 0.0009162505433465 0.0069586663392923 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 2 5 2.129841148385085 0.0331847302262424 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 0.0008300469730069 0.0029026051361948 0.0009162505433465 0.0069586663392923 +Single hybrid motif [IPR011053] 5 8 2.108298690128759 0.0350051611914827 5.182038834951456 8.361650485436893 -2.130161056715037 0.0953326994482326 1.4807396860722422 0.6846338360686358 1.3497960821287889 0.2162773212056401 1.0 1.0 0.0043816077243747 2.57182983485772e-06 3.888277844411057e-06 +START-like domain superfamily [IPR023393] 2 5 1.962912737464908 0.0496563144709574 1.2378640776699028 4.002427184466019 0.8283293408410919 0.3306194338838688 1.0248008572689138 0.966674778916386 1.1037443703999703 0.2840707200858018 1.0 0.0802348466038066 0.0104522439456993 0.0573204241328388 0.0426631312781282 +Catenin binding domain superfamily [IPR027397] 2 5 1.962289180934736 0.0497288260933528 1.4611650485436891 2.8640776699029127 -0.3175725457270917 0.4309607721618551 0.927438586636484 0.8763178003277519 1.2825653701699795 0.3294665485384441 1.0 1.0 1.0 0.2616334283931401 0.0206036852780843 +Cadherin-like superfamily [IPR015919] 2 5 1.962289180934736 0.0497288260933528 1.645631067961165 3.320388349514563 -0.2402178645885725 0.4384898024191497 1.130192585962622 1.2673157339720058 1.2853782186760632 0.3326205753213853 1.0 1.0 1.0 0.4016214295658294 0.0814592868847364 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5d719cef915a196a6e5b945c3522e23ddbadd619 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 952, + "title": "Average number of proteins per term", + "value": 4.723739495798319 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..db4d4062179aab059e12dd40d657774fefce26c7 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..11fea65c659acf4b94f48f97e623e2dce1cee8fe --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,138 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Rudiment single hybrid motif [IPR011054] 0.9074622723928188 2.4729387560106573 0.0134007105673723 0.9999973573477416 0.4549065208556196 6 P11498,O00763,Q96RQ3,P05165 4 +Pre-ATP-grasp domain superfamily [IPR016185] 0.8123752841576859 2.3470079680493137 0.018924850064274 0.9999999873943222 0.4549065208556196 8 P11498,O00763,Q96RQ3,P05165 4 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.7347563938146371 2.225605565190574 0.0260406131043737 0.9999999999876722 0.4549065208556196 18 Q8NB78,O95831 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.862951099035985 2.1298411483850854 0.0331847302262424 0.9999999999999888 0.4549065208556196 5 P55786,Q9NZ08 2 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.862951099035985 2.1298411483850854 0.0331847302262424 0.9999999999999888 0.4549065208556196 5 P55786,Q9NZ08 2 +Single hybrid motif [IPR011053] 0.7594253527917632 2.108298690128759 0.0350051611914827 0.999999999999998 0.4549065208556196 8 P11498,P05165,Q96RQ3,O00763,Q13085 5 +Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940] 0.8657337026239511 1.9872765754435793 0.0468917560289741 1.0 0.455210023469922 4 Q9UBF8,P42345 2 +START-like domain superfamily [IPR023393] 0.8226519450391492 1.962912737464908 0.0496563144709574 1.0 0.455210023469922 5 Q9NQZ5,Q14849 2 +Catenin binding domain superfamily [IPR027397] 0.8225026231610645 1.962289180934736 0.0497288260933528 1.0 0.455210023469922 5 Q08554,Q14574 2 +Cadherin-like superfamily [IPR015919] 0.8225026231610645 1.962289180934736 0.0497288260933528 1.0 0.455210023469922 5 Q08554,Q14574 2 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.5156776362821339 1.904372688934891 0.0568616635093384 1.0 0.4607392859102296 83 Q9H7B4,O75153,Q9UPR3,O00231,O14579,Q15006,Q9NRG4,Q6DKK2,Q9BZJ0,Q9Y5Q9,Q96TC7,O43765,Q9UGR2,Q13451,Q32P28,Q9BQ70,Q00610,Q6PGP7,O15091,Q13217,O76024,Q6P2P2,Q96EK5,Q99615,Q9BXJ9,A0AVF1,Q5R3I4,Q6PD62,O95801,Q9Y6X3,Q7L5D6,P42345 32 +NAP-like superfamily [IPR037231] 0.8967444919434371 1.637276330294239 0.10157274430785 1.0 0.592264320826939 3 P55209,Q99733 2 +GINS, helical bundle-like domain superfamily [IPR036224] 0.7745641658059925 1.6146633785440432 0.1063836122493766 1.0 0.592264320826939 4 Q14691,Q9Y248 2 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.6041470163873395 1.5327622131786605 0.1253344541056864 1.0 0.6564088484219575 18 P28074,P28070,P49721 3 +HECT, E3 ligase catalytic domain [IPR035983] 0.6081169165318459 1.515106650526743 0.129745397746932 1.0 0.6564088484219575 9 O95071,Q96PU5,Q15386 3 +DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921] 0.7014522913589288 1.446341936689927 0.1480813187846124 1.0 0.6564088484219575 5 P40937,P40938 2 +Sec23/Sec24 helical domain superfamily [IPR036175] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.6564088484219575 4 O95487 1 +Gelsolin-like domain superfamily [IPR036180] 0.7340154158019789 1.446056536351965 0.1481613450921162 1.0 0.6564088484219575 4 O95487 1 +PUA-like superfamily [IPR015947] 0.6176702694647207 1.4395578635532351 0.1499925281064769 1.0 0.6564088484219575 8 Q9ULC4,Q9P016,O43252 3 +Mitochondrial carrier domain superfamily [IPR023395] 0.5785432306460145 1.4191880226263751 0.155844206919002 1.0 0.6564088484219575 20 O43772,Q9Y6C9,Q9H2D1,O43808,Q9BSK2 5 +Immunoglobulin E-set [IPR014756] 0.5886626076873013 1.413505317719178 0.1575071989219729 1.0 0.6564088484219575 13 A6NIH7 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.5681478752124924 1.313824862555506 0.1889051487557789 1.0 0.7119737642894479 9 Q92804,P35637,Q01844 3 +HSP40/DnaJ peptide-binding [IPR008971] 0.8104045804520501 1.3095592064503947 0.1903449962494199 1.0 0.7119737642894479 3 O60884 1 +Bromo adjacent homology (BAH) domain superfamily [IPR043151] 0.6967325163808114 1.2902382874564051 0.1969679363391498 1.0 0.7184424344631061 4 O94776,P26358 2 +Chaperone J-domain superfamily [IPR036869] 0.5598846333986072 1.2687536704513855 0.2045289337270217 1.0 0.7238347394354078 15 O60884,Q13217,O75165,Q99615,Q99543,P31689 6 +Homeobox-like domain superfamily [IPR009057] 0.5556861155686759 1.258492449853499 0.2082137160235171 1.0 0.731437113115824 17 Q8NB78,Q96G23 2 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.684882618599757 1.2406801683830562 0.2147239232471403 1.0 0.7415889920482029 4 Q9BYT8 1 +von Willebrand factor A-like domain superfamily [IPR036465] 0.5497458252330756 1.2115982239 0.2256662147844648 1.0 0.753804338508107 14 Q99829,O95487,P53992,Q96SY0,Q9NU22 5 +Acyl-CoA N-acyltransferase [IPR016181] 0.5454695507449177 1.198897794701969 0.2305676893685542 1.0 0.7542970456318336 9 Q86UY6,Q9H9T3 2 +Protein kinase-like domain superfamily [IPR011009] 0.4030287872069498 1.1942478913799612 0.2323810143754727 1.0 0.7565333898479439 67 P17612,Q05397,Q9UHY1,P78362,Q86UE8,P48729,P11802,P50750,Q9UBF8,P31751,Q9HA64,Q13555,P35790,P31749,P78527,P42345,Q9Y4A5 17 +Zinc finger, Sec23/Sec24-type superfamily [IPR036174] 0.7797263596526083 1.1930733856889597 0.232840633640176 1.0 0.7565333898479439 3 O95487 1 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.7690006105895117 1.1524713017502055 0.2491274559957164 1.0 0.784005291688254 3 Q9BYT8 1 +ATP-grasp fold, subdomain 1 [IPR013815] 0.5803950489718446 1.147905905491778 0.2510074100357182 1.0 0.7860495209013283 7 O00763,P05165 2 +Initiation factor 2B-like, C-terminal [IPR042529] 0.65931927612808 1.1339389610391255 0.2568201527509128 1.0 0.7938077448664579 4 Q9UI10,P49770 2 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.5733371051335284 1.1147942438183944 0.2649386037150543 1.0 0.8007033356721641 7 Q9BUK6 1 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.979947403024328 1.0932664505743592 0.2742768286022961 1.0 0.8130271296349244 2 A6NIH7 1 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.5208863070020068 1.0643278609318616 0.2871802009121875 1.0 0.8234805761096462 16 O15217 1 +Cyclin-like superfamily [IPR036915] 0.7423729097555287 1.052155119969422 0.292728386570487 1.0 0.8244894201630286 3 O95067 1 +Zinc-binding ribosomal protein [IPR011332] 0.7398814655393021 1.0428141018544126 0.2970343988383552 1.0 0.8266546435035413 3 P61927 1 +p53-like transcription factor, DNA-binding [IPR008967] 0.7272647889517616 0.9956599505571904 0.3194153954324688 1.0 0.8400095482091444 3 P40763 1 +WW domain superfamily [IPR036020] 0.5052228173407673 0.9833098070081678 0.3254549848845181 1.0 0.8465386492078174 11 Q96J02,Q96PU5,O60828,Q13526 4 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.6174342105263239 0.9604513092848772 0.3368281252837692 1.0 0.8550943340537289 4 P10321,Q9UNN8,P04439 3 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.6174342105263239 0.9604513092848772 0.3368281252837692 1.0 0.8550943340537289 4 P10321,Q9UNN8,P04439 3 +Ribosomal L18e/L15P superfamily [IPR036227] 0.7124163307096388 0.9405340181025956 0.346943708801652 1.0 0.8623770516427487 3 P46776 1 +TGS-like [IPR012676] 0.5464121132323865 0.8923321392798707 0.3722149325111101 1.0 0.8858412046417894 6 Q9NYK5,P55039,Q9BW92,P26639,Q9NTK5 5 +AF1104-like superfamily [IPR036075] 0.9066403681788286 0.8487510441812823 0.3960198364593952 1.0 0.8912786863105066 2 Q9NVE7 1 +Zinc finger, ZZ-type superfamily [IPR043145] 0.5789758108856558 0.8043979550352173 0.421167181833793 1.0 0.9095596526554122 4 Q13501,P46939 2 +EF-hand domain pair [IPR011992] 0.3258917809065711 0.7969196809140274 0.4254976799442049 1.0 0.9099175121236296 47 P80303,Q9Y680,P60660,P41208,O43852,Q9NWM8,P22681,Q9BRK5,Q15293,Q14257,O95302,Q02818 12 +Beta-grasp domain superfamily [IPR012675] 0.5030189319759465 0.7887433177746598 0.430262044479635 1.0 0.9099175121236296 7 Q9NYK5,P55039,Q9BW92,P26639,Q9NTK5 5 +6-phosphogluconate dehydrogenase, domain 2 [IPR013328] 0.5436453643984341 0.7675733616870837 0.4427406933207582 1.0 0.9182080454127168 5 Q16836 1 +TFIIS/LEDGF domain superfamily [IPR035441] 0.5158147598455606 0.7580091207470985 0.4484455225904142 1.0 0.9182080454127168 6 Q7Z4V5,Q96ST2 2 +Rho GTPase activation protein [IPR008936] 0.4548144634870744 0.7353206143098345 0.4621442565404394 1.0 0.9360879409074432 10 P21359 1 +Six-hairpin glycosidase-like superfamily [IPR012341] 0.5252672517909435 0.6921236604437946 0.4888596741944697 1.0 0.9476656654219248 5 O43813,P33908 2 +MFS transporter superfamily [IPR036259] 0.4459072102430481 0.6848127549497977 0.4934620855601324 1.0 0.9490422332388808 11 Q16625,Q6N075,P41440 3 +RNA-binding S4 domain superfamily [IPR036986] 0.6388783840264316 0.6766749480501972 0.4986122147105662 1.0 0.9531703381615644 3 P62701 1 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.4737856828470963 0.6578315269324466 0.5106463935611942 1.0 0.9554229700718272 7 Q14145,P63208,Q9NXV2 3 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.4111379066071736 0.6533058125241783 0.5135591459298359 1.0 0.9554229700718272 31 P26358,Q96P11,O60678,Q86X55,Q8N1G2,P52788,Q6FI81,Q6P2P2,Q9BV86,Q99873 10 +TBP domain superfamily [IPR012295] 0.5134047390530363 0.6443392210873766 0.5193554876833977 1.0 0.9554229700718272 5 Q9Y678,Q9UBF2 2 +Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028] 0.5134047390530363 0.6443392210873766 0.5193554876833977 1.0 0.9554229700718272 5 Q9Y678,Q9UBF2 2 +Cullin repeat-like-containing domain superfamily [IPR016159] 0.4672374053341939 0.6291451075101924 0.5292540618624977 1.0 0.9570764617232832 7 Q13616,Q13620,Q9UPT5,Q13617,Q13618,Q9UID3 6 +L27 domain superfamily [IPR036892] 0.8339907955292529 0.6216337709158791 0.5341827096394223 1.0 0.9619222488953124 2 Q14168 1 +ESCRT assembly domain [IPR037202] 0.8326758711374203 0.6177235290743694 0.5367575992523126 1.0 0.9641381782796256 2 Q9H9H4 1 +Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864] 0.4314226404322646 0.5983380037219767 0.5496144235390863 1.0 0.976180841808228 15 Q9NP81,P50747,Q15046 3 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.8218277449046674 0.5857910087580522 0.5580159666216178 1.0 0.9863159963142448 2 O60884 1 +Ribosomal protein L4 domain superfamily [IPR023574] 0.8191978961209683 0.5781403593517079 0.5631693606886736 1.0 0.9863159963142448 2 Q9BYD3 1 +Kinesin motor domain superfamily [IPR036961] 0.4211281658344239 0.5550035654407922 0.5788922217015302 1.0 0.9863159963142448 20 Q86Y91,Q96Q89,Q9BW19,O43795,Q02241 5 +tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026] 0.6002986235431125 0.5477022022706155 0.5838963997161715 1.0 0.9863159963142448 3 Q13395 1 +Alpha/beta knot methyltransferases [IPR029028] 0.6002986235431125 0.5477022022706155 0.5838963997161715 1.0 0.9863159963142448 3 Q13395 1 +AH/BAR domain superfamily [IPR027267] 0.4175387451468722 0.5424565828566483 0.5875040093449808 1.0 0.9863159963142448 12 Q9UQB8 1 +Aldolase-type TIM barrel [IPR013785] 0.4173317012165505 0.5414832770107558 0.5881745211324434 1.0 0.9863159963142448 12 P43490 1 +ENTH/VHS [IPR008942] 0.4164591817488203 0.5373861350969822 0.5910009185032141 1.0 0.9863159963142448 12 O60784,Q96P16,Q92783,Q8IWX8 4 +High mobility group box domain superfamily [IPR036910] 0.4143108906569615 0.5222489783274104 0.6014969884136205 1.0 0.986650731236874 13 Q12873 1 +STAT transcription factor, DNA-binding, N-terminal [IPR012345] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.986650731236874 2 P40763 1 +STAT transcription factor, coiled coil [IPR015988] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.986650731236874 2 P40763 1 +STAT transcription factor, N-terminal domain superfamily [IPR036535] 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 0.986650731236874 2 P40763 1 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.7961867192636551 0.5128188679148143 0.6080780301995623 1.0 0.986650731236874 2 Q9BYT8 1 +Winged helix-like DNA-binding domain superfamily [IPR036388] 0.3355999984586282 0.5037152838798884 0.6144614665293613 1.0 0.986650731236874 41 P46783,Q12948,Q8NB78,P10412 4 +Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041] 0.4369443529798991 0.5004918231641489 0.6167288122769952 1.0 0.986650731236874 7 Q10567,O94973,Q9UJY4,O43747,Q9Y678,Q9UBF2 6 +Sterile alpha motif/pointed domain superfamily [IPR013761] 0.4310995131406857 0.4765751131445524 0.6336647084948508 1.0 0.986650731236874 7 Q92625,Q15375,Q9Y3Z3 3 +HAD-like superfamily [IPR036412] 0.4059305753061299 0.4738491920454799 0.6356074526793876 1.0 0.986650731236874 17 P78330,Q9H857,Q969T7 3 +HAD superfamily [IPR023214] 0.4059305753061298 0.4738491920454793 0.635607452679388 1.0 0.986650731236874 17 P78330,Q9H857,Q969T7 3 +Cullin homology domain superfamily [IPR036317] 0.4669299111549948 0.4663981935717436 0.6409305042843307 1.0 0.986650731236874 5 Q13616,Q13617,Q13618,Q13620 4 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.5655306728432163 0.439812645228542 0.6600728083099097 1.0 0.9898944897019978 3 P49356 1 +Ribonuclease H superfamily [IPR036397] 0.3824694447950668 0.4071577655252619 0.6838921189965881 1.0 1.0 9 Q9GZR2 1 +DUSP-like superfamily [IPR035927] 0.551134495231827 0.3979715203733818 0.6906511790043046 1.0 1.0 3 P51784,Q86UV5 2 +SH2 domain superfamily [IPR036860] 0.3698982735902328 0.3458065144534006 0.7294881290403668 1.0 1.0 10 P42224,P40763,P22681 3 +Chloramphenicol acetyltransferase-like domain superfamily [IPR023213] 0.4486032659526031 0.3358952206885451 0.7369498812264366 1.0 1.0 4 P23786 1 +Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091] 0.4221765395415119 0.3144398145550309 0.753187020814261 1.0 1.0 5 O95071 1 +NADP-dependent oxidoreductase domain superfamily [IPR036812] 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 O43488,P14550 2 +Zinc finger, CCHC-type superfamily [IPR036875] 0.4206399508243902 0.3096508689201971 0.7568264683941843 1.0 1.0 5 O95639 1 +Tubulin/FtsZ, C-terminal [IPR008280] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Tubulin, C-terminal [IPR023123] 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +Ribonuclease H-like superfamily [IPR012337] 0.3540856017077437 0.2755720563008192 0.7828767747255183 1.0 1.0 11 Q9GZR2 1 +PH-like domain superfamily [IPR011993] 0.2664267073015148 0.2742323004277487 0.783906107074787 1.0 1.0 53 Q05397,Q15036,Q86X55,O14654,P31751,P22059,P21359,Q92888,P31749,O60333 10 +Immunoglobulin-like domain superfamily [IPR036179] 0.3562514386931407 0.260383371431019 0.7945680683710745 1.0 1.0 16 Q5ZPR3 1 +ADF-H/Gelsolin-like domain superfamily [IPR029006] 0.3466396143553666 0.2356924177641359 0.8136713539144564 1.0 1.0 13 O95487,Q13045 2 +Bromodomain-like superfamily [IPR036427] 0.3491089827871624 0.233245355913944 0.815570888008017 1.0 1.0 16 Q9UPN9,Q9H8M2,Q9NPI1 3 +Coatomer, gamma subunit, appendage domain superfamily [IPR037067] 0.6646942800788944 0.2119686685772241 0.8321314777528488 1.0 1.0 2 Q9Y678 1 +Zinc finger, RING/FYVE/PHD-type [IPR013083] 0.2520281394158121 0.208101382705909 0.8351498075510357 1.0 1.0 51 O95376,Q12873,O94822,Q9UPN9,P29083 5 +Translation elongation factor eEF-1beta-like superfamily [IPR036219] 0.6584483892176172 0.2013574229152592 0.8404191049142333 1.0 1.0 2 P29692 1 +Translation elongation factor EF1B/ribosomal protein S6 [IPR014717] 0.6584483892176172 0.2013574229152592 0.8404191049142333 1.0 1.0 2 P29692 1 +B30.2/SPRY domain superfamily [IPR043136] 0.3291217049723554 0.1859352662843977 0.852495525907127 1.0 1.0 11 Q9UBL3,P19474,Q9BUJ2 3 +PDZ superfamily [IPR036034] 0.3368093073528113 0.1852791364019058 0.8530101014511076 1.0 1.0 21 Q9HD26,Q53GG5,P57105,Q9UDY2,Q14168,Q9NZW5 6 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.3421636817329086 0.1670937347773127 0.8672962956354322 1.0 1.0 7 O43847,P31930 2 +Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056] 0.611111111111107 0.1328488864359855 0.8943128911901996 1.0 1.0 2 P07814 1 +Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035] 0.611111111111107 0.1328488864359855 0.8943128911901996 1.0 1.0 2 P07814 1 +Nucleoside diphosphate kinase-like domain superfamily [IPR036850] 0.4119312231343535 0.1083149391363728 0.913745872618294 1.0 1.0 3 P22392 1 +Six-hairpin glycosidase superfamily [IPR008928] 0.4108870585600619 0.1070207528396692 0.9147725159212468 1.0 1.0 3 P46020 1 +Myosin S1 fragment, N-terminal [IPR008989] 0.3457236842105332 0.1013267440846149 0.9192910867369266 1.0 1.0 4 Q7Z406,Q9UM54,P35580 3 +K homology domain-like, alpha/beta [IPR015946] 0.5775805391189919 0.0967598500861713 0.9229171092573036 1.0 1.0 2 O75616 1 +K homology domain superfamily, prokaryotic type [IPR009019] 0.5775805391189919 0.0967598500861713 0.9229171092573036 1.0 1.0 2 O75616 1 +Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001] 0.3300427772293631 0.0910588390010571 0.9274458384332916 1.0 1.0 5 O00178,Q9Y450,P49411,Q05639 4 +Death-like domain superfamily [IPR011029] 0.3141222343707585 0.0805269067981609 0.9358181971887888 1.0 1.0 6 Q13546,Q7Z434 2 +NagB/RpiA transferase-like [IPR037171] 0.3099611219356721 0.0730642611076607 0.9417549811214128 1.0 1.0 6 Q9UI10,P49770 2 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase Rpb2, OB-fold [IPR014724] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +RNA polymerase Rpb2, domain 2 superfamily [IPR037034] 0.5223537146613948 0.05725012474477 0.95434594983242 1.0 1.0 2 Q9H9Y6 1 +Papain-like cysteine peptidase superfamily [IPR038765] 0.2913558373093783 0.054203151751657 0.956773309643396 1.0 1.0 25 Q96RU2,Q9Y4P1,P07384,Q96K76,Q96FW1,Q13867 6 +Phosphofructokinase superfamily [IPR035966] 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 1.0 3 P08237 1 +Creatinase/aminopeptidase-like [IPR036005] 0.2932850559578698 0.0463631321839219 0.9630208211518488 1.0 1.0 6 Q9UQ80,Q9NQW7,P50579,Q9NQH7,Q9Y5B9 5 +L-Aspartase-like [IPR008948] 0.4970414201183319 0.0459911079456646 0.963317337242958 1.0 1.0 2 P07954 1 +Ribosomal protein S10 domain superfamily [IPR036838] 0.4878369493753967 0.0427573259971151 0.9658949817782776 1.0 1.0 2 P60866 1 +Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149] 0.293092105263166 0.0425184636669794 0.9660853931814876 1.0 1.0 4 Q9NQH7,Q9NQW7,Q9Y5B9 3 +Pyridoxal phosphate-dependent transferase, small domain [IPR015422] 0.279758495504097 0.0407845992150256 0.9674676171893664 1.0 1.0 13 O15270,P34897,P34896 3 +Formin, FH2 domain superfamily [IPR042201] 0.2851973684210589 0.0368393847941423 0.9706130708244164 1.0 1.0 4 Q9NSV4,O60610,Q9Y613 3 +Ricin B-like lectins [IPR035992] 0.2847693545831379 0.0365518827039651 0.9708423099074251 1.0 1.0 4 Q10471 1 +Mib/herc2 domain superfamily [IPR037252] 0.4651545036160279 0.0364361046517749 0.9709346259334476 1.0 1.0 2 O95714 1 +Cytidine deaminase-like [IPR016193] 0.463510848126226 0.0360592757611797 0.9712350944286556 1.0 1.0 2 P31939 1 +Zinc finger, CCCH-type superfamily [IPR036855] 0.2721527332545553 0.0298274689614726 0.9762046514460944 1.0 1.0 8 Q9UGR2 1 +Inorganic pyrophosphatase superfamily [IPR036649] 0.4220907297830341 0.0293819913825809 0.976559935398878 1.0 1.0 2 Q9H2U2 1 +Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919] 0.2863247863247884 0.0249966338565518 0.9800576485643442 1.0 1.0 2 P18124 1 +Ubiquitin-like domain superfamily [IPR029071] 0.2479876213529835 0.023455983269865 0.9812865490771568 1.0 1.0 39 Q05397,Q15813,Q5TDH0,Q9UPU5,Q96K76,Q9BZL1,Q8NCF5,Q9NZ01 8 +SH3-like domain superfamily [IPR036028] 0.2767484936122321 0.022988288759904 0.981659614697764 1.0 1.0 26 Q9UDY2,A1X283,Q92783,Q9UQB8,Q14168 5 +SNF2-like, N-terminal domain superfamily [IPR038718] 0.2679468898128192 0.0176319793540109 0.985932444803442 1.0 1.0 13 Q12873,Q9H4L7 2 +Pyridoxal phosphate-dependent transferase [IPR015424] 0.2627642723190637 0.0057320795177939 0.995426487296588 1.0 1.0 14 O15270,P34897,P34896 3 +Pyridoxal phosphate-dependent transferase, major domain [IPR015421] 0.2627642723190637 0.0057320795177939 0.995426487296588 1.0 1.0 14 O15270,P34897,P34896 3 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a07c6883ee2364f453d2ff2c11da4e7c64b3b426 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "APC, N-terminal coiled-coil domain superfamily [IPR036149]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adaptor protein Cbl, N-terminal domain superfamily [IPR036537]", "Adenomatous polyposis coli protein [IPR026831]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "Apyrase superfamily [IPR036258]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "CalX-like domain superfamily [IPR038081]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Caspase-like domain superfamily [IPR029030]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Copper homeostasis (CutC) domain superfamily [IPR036822]", "Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily [IPR036939]", "Copper type II, ascorbate-dependent monooxygenase-like, C-terminal [IPR014784]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA glycosylase [IPR011257]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, subunit B, N-terminal domain superfamily [IPR043034]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FMN-binding split barrel [IPR012349]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Focal adhesion kinase, targeting (FAT) domain superfamily [IPR036137]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glu-tRNAGln amidotransferase superfamily, subunit C [IPR036113]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "Green fluorescent protein [IPR009017]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "H/ACA ribonucleoprotein complex, subunit Nop10 superfamily [IPR036756]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix hairpin bin domain superfamily [IPR029012]", "Helix-hairpin-helix, base-excision DNA repair, C-terminal [IPR023170]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone chaperone ASF1-like superfamily [IPR036747]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrase-like, N-terminal [IPR017856]", "Integrin alpha, N-terminal [IPR028994]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "Janus superfamily [IPR038596]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Lipid transport protein, beta-sheet shell [IPR015819]", "Lipovitellin-phosvitin complex, superhelical domain [IPR011030]", "Longin-like domain superfamily [IPR011012]", "LysM domain superfamily [IPR036779]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthioribose-1-phosphate isomerase, N-terminal [IPR027363]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PCGF Ub-like fold discriminator superfamily [IPR038227]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHM/PNGase F domain superfamily [IPR008977]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Rad4, beta-hairpin domain 3 superfamily [IPR042488]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Receptor L-domain superfamily [IPR036941]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rubisco LSMT, substrate-binding domain superfamily [IPR036464]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SAS-6, N-terminal domain superfamily [IPR038558]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Seven-hairpin glycosidases [IPR036026]", "Sialidase superfamily [IPR036278]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Snake toxin-like superfamily [IPR045860]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Soluble quinoprotein glucose/sorbosone dehydrogenase [IPR011041]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thyroglobulin type-1 superfamily [IPR036857]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transcriptional regulator TACO1-like, domain 3 [IPR026564]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transglutaminase-like superfamily [IPR036985]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tubby-like, C-terminal [IPR025659]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vitellinogen, beta-sheet N-terminal [IPR015816]", "Vitellinogen, open beta-sheet, subdomain 1 [IPR015817]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YebC-like [IPR029072]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "mRNA decapping protein 2, Box A domain superfamily [IPR036189]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATXN10", "AURKA", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCL10", "BCL2L12", "BCL2L13", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BROX", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPM", "CENPV", "CEP170", "CERK", "CERS2", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNOT9", "CNP", "COA7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCP2", "DCPS", "DCTN1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERH", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM234B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GOLPH3L", "GOPC", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IDE", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPDH1", "IMPDH2", "INF2", "INTS12", "INTS14", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KLHDC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAP2K4", "MAP4K5", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED16", "MEPCE", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL4", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS15", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCBP1", "NCDN", "NCK1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEK9", "NELFE", "NENF", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHLRC2", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4KB", "PICALM", "PIK3C2A", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEPK", "RABGAP1", "RABGGTB", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REPS1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSF1", "RSL1D1", "RTCB", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART3", "SASS6", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1", "SPECC1L", "SPEN", "SPOUT1", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX10", "STX12", "STX3", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFRC", "THADA", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMA16", "TMED2", "TMED5", "TMED7", "TMEM14C", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTI1", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UFC1", "UFD1", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VLDLR", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR73", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZDHHC13", "ZFR", "ZFYVE16", "ZMYND8", "ZNF281", "ZNF346", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["ACACA", "ACACB", "AIFM1", "AKR1A1", "AKR7A2", "AKT1", "AKT2", "ANKS1A", "AP1B1", "AP1G1", "AP2A2", "ARHGEF1", "ARIH2", "ASH2L", "ATG4B", "ATIC", "BAIAP2", "BLMH", "BRD7", "BRD9", "CALU", "CAMK2G", "CAPN1", "CARM1", "CBL", "CCNB2", "CD276", "CDK4", "CDK9", "CERS2", "CETN2", "CHD3", "CHERP", "CHKA", "CIAPIN1", "CLTC", "CLUH", "CMTR1", "COPE", "COPG1", "COPG2", "CPNE1", "CPSF4", "CPT2", "CRNKL1", "CSNK1A1", "CTR9", "CUL1", "CUL2", "CUL3", "CUL4B", "DDI2", "DIAPH1", "DIAPH3", "DNAJA1", "DNAJA2", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNMT1", "DRG2", "DSC1", "DSC3", "EEF1A2", "EEF1D", "EIF2B2", "EIF2B4", "ELP3", "EMC2", "EPHA7", "EPRS", "ERAL1", "ERAP1", "EWSR1", "EXOC7", "FH", "FHOD1", "FKBP14", "FKBP5", "FKBP7", "FKBP9", "FLII", "FN3KRP", "FNTB", "FOXC1", "FUS", "GALNT2", "GET4", "GGA2", "GINS1", "GINS2", "GOPC", "GSTA4", "GTF2E1", "GTF3C3", "GTPBP1", "HADH", "HBS1L", "HDGFL2", "HERC2", "HIST1H1E", "HLA-A", "HLA-C", "HLCS", "HNRNPUL1", "INTS14", "IRS4", "ITCH", "IWS1", "KARS", "KCTD5", "KDM1B", "KEAP1", "KIAA0391", "KIF18B", "KIF1B", "KIF20B", "KIF23", "KIFBP", "KIFC1", "LANCL1", "LTN1", "MAN1A1", "MAU2", "MAVS", "MCCC1", "MCTS1", "MDN1", "METAP2", "MFSD5", "MPP2", "MPP6", "MRPL39", "MRPL4", "MSTO1", "MTA2", "MTCH2", "MTOR", "MYH10", "MYH14", "MYL6", "MYO1B", "MYO6", "NAA15", "NAA40", "NAMPT", "NAP1L1", "NAP1L4", "NEDD4L", "NF1", "NFATC2IP", "NLN", "NME2", "NPEPPS", "NRBP1", "NRDC", "NSUN5", "NT5C3B", "NT5DC2", "NTMT1", "NUCB1", "NUCB2", "OCLN", "OLA1", "OSBP", "OTUB1", "P3H1", "PA2G4", "PANK4", "PAPSS1", "PC", "PCCA", "PDLIM3", "PFKM", "PHKA1", "PI4KB", "PIN1", "POLR1B", "PPA2", "PQBP1", "PRKACA", "PRKDC", "PRMT1", "PRMT3", "PRMT9", "PROCR", "PSMB2", "PSMB4", "PSMB5", "PSMD11", "PSPH", "PTK2", "RCN1", "RCN2", "REXO4", "RFC3", "RFC5", "RIPK1", "RMDN3", "RPL27A", "RPL37", "RPL7", "RPRD1A", "RPS10", "RPS20", "RPS4X", "SAMHD1", "SARS2", "SDF4", "SEC24B", "SEC24C", "SGTA", "SH3PXD2B", "SHMT1", "SHMT2", "SKP1", "SLC19A1", "SLC25A17", "SLC25A20", "SLC25A32", "SLC25A33", "SMARCAD1", "SMG5", "SMS", "SMYD2", "SMYD3", "SNX17", "SPTLC2", "SQSTM1", "SRPK2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "SUPT16H", "SYNJ2BP", "TAF15", "TARBP1", "TARS", "TARS2", "TBCE", "TCF25", "TECR", "THYN1", "TJP2", "TLK2", "TOM1", "TRIM21", "TRIM33", "TRRAP", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TUBB", "TUBB4A", "TUFM", "UBE3C", "UBL5", "UBR5", "UNC119B", "UQCRC1", "USP11", "USP24", "USP28", "USP47", "USP48", "UTRN", "VPS37B", "VPS51", "WFS1", "XPNPEP1", "XPNPEP3", "ZC3H7B"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f3887b6a69db7dfbfec344bef5c5f14e57a535cf --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d3ec3c38d79412f4079d9d6b2fcce06cbf0377df35f2a3d690c60dc535ef000c +size 67048 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..4c0238a73924db8d9b47d7868709bec97ce5688a --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 3.5 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..769d6c59fef8c42bd7da7d91055a89a820563c9c --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..098c07c6916767585cbfeb0b6c71e16e2cec8630 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EGF-type aspartate/asparagine hydroxylation site [IPR000152] 0.4451836099869378 0.5347451627203742 0.5928260872086564 0.97251347852406 0.9124691394962654 7 P48960 1 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ded24fbd4f12c550ac976354226a22fdac0c3c0c --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ADGRE5", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP7A", "EIF5A", "FASN", "LDLR", "LRP1", "LRP2", "NID1", "SLIT2", "VLDLR"], "leading_proteins": ["ADGRE5"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e74ae11347363070f6d0e43c498b056822f1753d --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tetratricopeptide repeat [IPR019734]", "1": "HEAT, type 2 [IPR021133]", "2": "Mitochondrial substrate/solute carrier [IPR018108]", "3": "Spectrin/alpha-actinin [IPR018159]", "4": "Tetratricopeptide repeat 1 [IPR001440]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ac6771ba84e2bab19ec033dbea7c273767ef2d21 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6be26518f6713e698f4fc695c46dab329003625440dc803849e4a415d6434e07 +size 128707 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..43c85a7f94837c3bea193a5cc9258731cdfbc68e --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9f964f848566cacc25236d500b821733840df187e8804c925151af09b11a4563 +size 127044 diff --git a/interpro_repeat/basic/plot_2.png b/interpro_repeat/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..eb765a1ccb0b4a86b27ac8a6a7801066c0e2fcf0 --- /dev/null +++ b/interpro_repeat/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5fba6ea96b7240fce540858a3e6c5532d1c14f0c07668dfa3457cb1fcafc4216 +size 143205 diff --git a/interpro_repeat/basic/plot_3.png b/interpro_repeat/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..84a3a988439510ef13fb987b001078bc00ea0157 --- /dev/null +++ b/interpro_repeat/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:07183bd4a1b7818e3dc369167d0f42948600bd6d38fc1d6c8825cb571fe0ac88 +size 144908 diff --git a/interpro_repeat/basic/plot_4.png b/interpro_repeat/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..7642c4503bebcccc1710aa5ec1881cf7e2bfa916 --- /dev/null +++ b/interpro_repeat/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:02af0519a7f2487a0aa92b424d424d05597bed70beccfbc460379566e5adb6db +size 148929 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f0fc77ab78a072bfc0314c160ade77e491555c3e --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4908754781426eeffa091eac9f3f839b4edf8285e77f64cbb8a7c15b99690dd3 +size 69228 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1b3c5e585a7e1684842780d99c10bc0455632c01 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 84, + "title": "Average number of proteins per term", + "value": 4.964285714285714 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ff3bc24d408d7b1325a3be3fb817891ff5934916 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1c2edef4f322c60f3775fe5e4b4333ad6ac885f7 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,13 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tetratricopeptide repeat [IPR019734] 0.4963299578262149 1.8723361927608584 0.0611601065645794 0.9950147266081708 0.4726240910060845 42 Q6DKK2,Q9Y5Q9,O43765,Q9UGR2,P30260,Q07866,Q13451,Q6PGP7,Q13217,O76094,Q6P2P2,Q02790,Q99615,Q9BXJ9,Q99614,A0AVF1,Q6PD62,O95801,Q9Y6X3,O15294,P31948,Q15006 22 +HEAT, type 2 [IPR021133] 0.6089838124726011 1.516817900932366 0.1293126661753667 0.9999911197121965 0.4726240910060845 10 P30153,P30154,Q9NXF1,Q92616,Q9BU89 5 +Mitochondrial substrate/solute carrier [IPR018108] 0.5785432306460145 1.4191880226263751 0.155844206919002 0.999999340068534 0.4726240910060845 20 O43772,Q9Y6C9,Q9H2D1,O43808,Q9BSK2 5 +HEAT repeat [IPR000357] 0.6686410003290518 1.3039456634662894 0.1922521094424549 0.9999999837381508 0.4726240910060845 5 O00410,P30153,Q6PJG6,P30154 4 +PFTB repeat [IPR001330] 0.868507560815263 0.727050566921206 0.4671949794144994 1.0 0.6502163090457059 2 P49356 1 +Spectrin/alpha-actinin [IPR018159] 0.4451688975894039 0.6961705724642334 0.48632201441331 1.0 0.6502163090457059 9 Q15149,Q13813,P15924,P46939,O43707 5 +Tetratricopeptide repeat 2 [IPR013105] 0.6428806313712576 0.6905078117800115 0.4898748991044395 1.0 0.6502163090457059 3 P31948,Q02790 2 +Calponin repeat [IPR000557] 0.5367484118032531 0.3580400250487845 0.7203133606839669 1.0 0.8757028865680149 3 Q15417 1 +Tetratricopeptide repeat 1 [IPR001440] 0.3169322110343795 0.1532643188011731 0.8781898376582342 1.0 0.9648236096678222 10 O43765,Q99614,P30260,Q13451,Q02790 5 +Spectrin repeat [IPR002017] 0.3154541624278804 0.1003389731643015 0.9200752174899484 1.0 0.9648236096678222 7 O43707,Q13813,P46939 3 +Armadillo [IPR000225] 0.3059326486603206 0.0938213372378363 0.9252510817812108 1.0 0.9648236096678222 16 P14923,O00505,Q6NXE6,P25054 4 +Leucine rich repeat 4 [IPR025875] 0.3795573151469983 0.0740403187957583 0.9409783035257048 1.0 0.9648236096678222 3 Q13045 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4948419bf66f810801b4d88538028915f75a9f3b --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Adenomatous polyposis coli (APC) repeat [IPR041257]", "Adenomatous polyposis coli protein repeat [IPR009223]", "Adenomatous polyposis coli protein, 15 residue repeat [IPR009240]", "Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Beta-propeller repeat TECPR [IPR006624]", "CSPG repeat [IPR039005]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "FG-GAP repeat [IPR013517]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Furin-like repeat [IPR006212]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "Integrin alpha beta-propellor [IPR013519]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "MORN motif [IPR003409]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "SAMP [IPR009224]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "YD repeat [IPR006530]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AGAP3", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKRD17", "ANKS1A", 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"LASP1", "LDLR", "LLGL1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MED16", "MKI67", "MRPS27", "MTCH1", "MTCH2", "NAA15", "NASP", "NEK9", "NHLRC2", "NID1", "NIPBL", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PAM", "PDCD11", "PHIP", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABEPK", "RABGGTB", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RRP9", "SART3", "SCML2", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SETD7", "SGTA", "SHOC2", "SIN3A", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", 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0.004307590720862 +Anoikis 3 9 2.1669302673471647 0.0302401716485085 2.516990291262136 7.075242718446602 -0.2727540937515956 0.6554836150713411 1.6091976743848304 1.3623468790134392 0.6095292831362777 0.2677567487215943 1.0 1.0 0.2069157251646864 0.1123180455797786 0.02759176986134 +Modification of postsynaptic structure 4 7 2.159477951396351 0.0308131060807479 1.720873786407767 6.691747572815534 0.6941377574078058 0.4017689645559979 1.65090478681785 0.5210425083463128 0.996138198164031 0.3082748387049209 1.0 0.0619434524836269 0.1135034587553153 0.2616334283931401 0.0206036852780843 +Negative regulation of peptidyl tyrosine phosphorylation 4 7 2.1280736133576723 0.0333309806754293 2.283980582524272 8.191747572815533 0.0826067157570953 0.5351854798325026 1.6588789288534094 1.8446011104487785 0.8853982134307216 0.2871771955152977 1.0 1.0 1.0 0.5786584257276657 0.5232170285300836 +Regulation of fibroblast migration 4 10 2.12562998033619 0.0335340812698432 3.0436893203883497 8.436893203883495 -0.318116747607059 0.5091206059376777 2.015241434518581 1.3611809757665452 0.8860697584238088 0.2934226931568082 1.0 1.0 0.2142453802458888 0.1199061038889744 0.0314378180168525 +Ether metabolic process 0 8 2.107735130435516 0.035053906760764 2.3009708737864076 8.116504854368932 0.6936598083237113 0.3993528168351505 1.8983127483146185 1.066260782267489 0.9725930071190376 0.2989456029254039 1.0 0.0847528009868792 0.1536793025675435 0.3430049269426823 0.5789571510851765 +Methionine metabolic process 0 6 2.075586242944849 0.0379322348809962 1.2135922330097086 5.288834951456311 0.6855396421636417 0.4233984316271269 1.2179920244361864 1.0152103430915898 0.923031017151648 0.2924657248910302 1.0 0.0619434524836269 0.1135034587553153 0.2616334283931401 0.1216833725914342 +Regulation of heart rate by cardiac conduction 1 5 2.074811375758427 0.0380040198653928 2.337378640776699 5.004854368932039 -0.6107424208180081 0.4350615436428127 1.2866985383048442 1.052032581057795 1.0718066164037 0.3363662080266201 1.0 1.0 1.0 0.0455986592907884 0.1542284426554127 +Secondary alcohol metabolic process 11 43 2.062589428237285 0.0391516530197602 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 0.0337015586481752 0.0008444118761584 0.0012186809265516 2.9530476091012107e-05 0.0001910574324899 +Isocitrate metabolic process 2 6 2.0500667763218283 0.0403579149543358 2.3276699029126213 5.495145631067961 -0.2061858290398174 0.3041702034210444 1.4604532504880654 0.4999764345469411 1.4464876184642763 0.300957520728341 1.0 1.0 1.0 0.0002296674643962 0.0018415390803392 +Positive regulation of fibroblast migration 2 5 2.0323344091189064 0.0421198132899527 1.2912621359223302 3.611650485436894 -0.2676038181657395 0.5114307257363334 0.8963904744814444 1.023823119856253 0.9627578853141678 0.3000427114015458 1.0 1.0 0.088498207465679 0.021070897570064 0.0095984867570286 +Response to l glutamate 1 5 2.0282645943729127 0.0425332504487823 1.029126213592233 4.37378640776699 1.2967513270419406 0.258405010407401 0.7465949978845596 0.5879801140961596 0.7687098467942305 0.2572187080379352 1.0 0.0008300469730069 0.0029026051361948 0.0171140643783894 0.0634541507870108 +Peptide catabolic process 4 10 2.0133697648268005 0.0440757439417311 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 1.0 0.0038211367015083 0.012986178174142 0.0008117771029233 0.00149186424952 +Protein demethylation 0 6 2.0034037096092354 0.0451339736220011 2.5364077669902914 7.594660194174757 0.0519052155682225 0.5126282210134702 2.1511195343824596 1.782675700042577 0.9963977055315628 0.3122725477399503 0.0113302238096159 0.1330370821365251 0.2358346075735272 0.4919440654366187 0.3972784135753906 +Genitalia development 0 6 2.0005053899181253 0.0454457184897323 0.7305825242718447 5.084951456310679 0.6929022329405563 0.4417126641011115 1.037049890892166 1.004874888397969 0.8649138953774324 0.292043177076853 0.0093836408426054 0.1114073342812727 0.1995184318712286 0.4289463167052597 0.6845355176813537 +Post translational protein modification 3 12 1.9878840133960685 0.0468245192090166 3.1941747572815533 11.516990291262136 0.7357713395172158 0.4534173687037079 1.6073753099185084 1.8147728922350523 0.7925975172795923 0.2972350127351547 1.0 0.141543756104335 0.0328837758174392 0.0053081510986454 0.0551715629817244 +Folic acid metabolic process 5 7 1.9818636881194345 0.0474944990036387 1.91747572815534 7.140776699029126 1.2977645388348351 0.249592124826322 1.215987926650751 0.8615786924829095 0.8405378716662024 0.2600707347072601 1.0 0.066549445548378 0.1216867716169547 0.0401162059364398 0.0032789531174172 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7d638b65b090b704091b7b5768a06c2ea77a6f35 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 6468, + "title": "Average number of proteins per term", + "value": 18.68692022263451 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6d57cfd5799676d41cef9fd59f8bb8e8dc2bc773 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8a3e81af0784b43a95a9effd097bc691e427b151 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1740 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein k48 linked ubiquitination 0.7769552883987834 2.3295005926943575 0.0198325616399832 1.0 1.0 9 O95376,Q96PU5,Q15386,O95071,P63208 5 +Fatty acid transmembrane transport 0.7872541634537925 2.23456314415415 0.0254460427323097 1.0 1.0 8 P23786,P31751,O43772,O14678 4 +Mitochondrial genome maintenance 0.7560753984350558 2.232519450332824 0.0255806511729741 1.0 1.0 9 P39210 1 +Ventricular cardiac muscle cell action potential 0.8409177419152585 2.196325154643194 0.0280686785139228 1.0 1.0 6 P14923,P15924,Q96PU5 3 +Anoikis 0.7420865632383609 2.1669302673471647 0.0302401716485085 1.0 1.0 9 Q05397,P49815,P42345 3 +Modification of postsynaptic structure 0.8012268743271787 2.159477951396351 0.0308131060807479 1.0 1.0 7 Q7L576,P35080,Q9UQB8,P61586 4 +Negative regulation of peptidyl tyrosine phosphorylation 0.7940796529122887 2.1280736133576723 0.0333309806754293 1.0 1.0 7 O95684,P22681,Q05655,Q99816 4 +Regulation of fibroblast migration 0.7328126954734827 2.12562998033619 0.0335340812698432 1.0 1.0 10 Q05397,P31749,O95429,Q9P258 4 +Regulation of heart rate by cardiac conduction 0.8495926832401338 2.074811375758427 0.0380040198653928 1.0 1.0 5 P15924 1 +Secondary alcohol metabolic process 0.5075170764150138 2.062589428237285 0.0391516530197602 1.0 1.0 43 Q15392,P98155,Q14739,P48735,P50213,Q06520,O75874,Q14534,Q16850,Q9UBM7,Q14849 11 +Isocitrate metabolic process 0.8065424486560278 2.0500667763218283 0.0403579149543358 1.0 1.0 6 P50213,P48735 2 +Mitochondrion distribution 0.8810535576676259 2.048775615276086 0.0404840612586601 1.0 1.0 4 O75153 1 +Positive regulation of fibroblast migration 0.8393315104565093 2.0323344091189064 0.0421198132899527 1.0 1.0 5 Q05397,O95429 2 +Response to l glutamate 0.838350606798117 2.0282645943729127 0.0425332504487823 1.0 1.0 5 O95831 1 +Peptide catabolic process 0.7094230316304491 2.0133697648268005 0.0440757439417311 1.0 1.0 10 P55786,Q8WUX2,Q9NZ08,Q9UIQ6 4 +Post translational protein modification 0.7025282719057182 1.9878840133960685 0.0468245192090166 1.0 1.0 12 Q32P28,Q9HA64,Q9Y4P8 3 +Folic acid metabolic process 0.7611164966989775 1.9818636881194345 0.0474944990036387 1.0 1.0 7 P41440,P34897,Q9H2D1,Q8IYS1,P34896 5 +Paraxial mesoderm development 0.8585820684915428 1.9584488291783473 0.0501773698868341 1.0 1.0 4 Q12948 1 +Positive regulation of epithelial to mesenchymal transition 0.7847504730270494 1.956191578890864 0.0504425901658809 1.0 1.0 6 Q12948 1 +Regulation of ventricular cardiac muscle cell action potential 0.8555868818915531 1.9463533828447357 0.0516123052342731 1.0 1.0 4 P15924 1 +Bundle of his cell to purkinje myocyte communication 0.8555868818915531 1.9463533828447357 0.0516123052342731 1.0 1.0 4 P15924 1 +Cellular response to corticosteroid stimulus 0.6918791062274667 1.9414864873110873 0.0521992968745463 1.0 1.0 13 Q9H7B4 1 +Nucleotide transmembrane transport 0.6935911124227321 1.935772396215292 0.052895583134523 1.0 1.0 9 Q9BSK2,O43808,P41440 3 +Detection of abiotic stimulus 0.7218229817650494 1.9348971381185445 0.0530029194687438 1.0 1.0 8 Q05397,Q15555,P14923 3 +Negative regulation of protein localization to cell surface 0.8525316573881445 1.9340022061449536 0.0531128566012875 1.0 1.0 4 Q9HD26 1 +Regulation of fatty acid oxidation 0.8524069675444298 1.9334978464059884 0.0531748981235984 1.0 1.0 4 P31751,O00763 2 +Modification of postsynaptic actin cytoskeleton 0.8154016354308782 1.9325943043365448 0.053286194627621 1.0 1.0 5 Q7L576,P35080,Q9UQB8 3 +Modification of synaptic structure 0.7211957076391181 1.9319778721646192 0.0533622371145452 1.0 1.0 8 Q7L576,P35080,Q9UQB8,P61586 4 +Negative regulation of jnk cascade 0.8117801908522556 1.9174189532425192 0.0551847282707544 1.0 1.0 5 Q96J02,P43034,P51452,P31689 4 +Negative regulation of stress activated protein kinase signaling cascade 0.6891951927786111 1.9145344566174196 0.0555519008167311 1.0 1.0 9 P43034,P51452,P78318,Q96KB5,Q96J02,P31689 6 +Modified amino acid transport 0.8107047889026935 1.9129085500664935 0.0557597608136073 1.0 1.0 5 O43772 1 +Demethylation 0.6768572267109372 1.8944078468397667 0.0581708956969695 1.0 1.0 16 Q8NB78 1 +Detection of mechanical stimulus 0.8374835360052665 1.8729758239340493 0.0610717235201956 1.0 1.0 4 Q05397,P14923 2 +Pyrimidine deoxyribonucleotide metabolic process 0.76529852362437 1.8716655073340096 0.0612528943786805 1.0 1.0 6 Q9H773 1 +Ventricular cardiac muscle tissue development 0.736142756242602 1.8696279977555903 0.0615354945254049 1.0 1.0 7 P15924,Q12948,O75844,P62942 4 +Steroid hormone biosynthetic process 0.7632383531897801 1.862674031466364 0.0625081416116746 1.0 1.0 6 Q14849 1 +Negative regulation of protein tyrosine kinase activity 0.7968923608187175 1.8548157456765264 0.0636225427592989 1.0 1.0 5 O95684,P22681 2 +Vascular endothelial growth factor receptor signaling pathway 0.729617372998159 1.8401016344144177 0.0657533173966422 1.0 1.0 7 Q12948 1 +Regulation of dna directed dna polymerase activity 0.673518729794422 1.8384244921765844 0.065999878832148 1.0 1.0 9 P40937,Q14691,Q9BRT9,Q9Y248 4 +Histone h3 k36 methylation 0.7292016283026272 1.8382177085304416 0.0660303313742931 1.0 1.0 7 Q96ST2,Q9NRG4 2 +Epithelial cell cell adhesion 0.7899658587184604 1.825573555907264 0.0679145220931809 1.0 1.0 5 P15924,P50452 2 +Axoneme assembly 0.9448907547784168 1.818227058039121 0.0690294360329586 1.0 1.0 3 A0AVF1 1 +Ethanol metabolic process 0.8216832347974847 1.808566328458738 0.070518403543857 1.0 1.0 4 Q06520 1 +Actin filament polymerization 0.4658681435095078 1.8056040180137396 0.0709802146113618 1.0 1.0 44 Q96F07,O95429,O94813,P16333,Q05655,Q9UQB8,P61586,O15511,Q13045,Q7L576,P42345,Q9NUQ9,P35080,Q96J84 14 +Positive regulation of glial cell differentiation 0.7491643328602692 1.8010536851727192 0.0716944187128127 1.0 1.0 6 Q9UPY3,P42345 2 +Ribonucleoside metabolic process 0.6918734715110745 1.7945768641127742 0.0727211420248079 1.0 1.0 8 Q13126 1 +Sulfur amino acid metabolic process 0.6636809952919507 1.789982925600862 0.0734566563235286 1.0 1.0 10 Q13126,Q13867 2 +Regulation of histone h4 acetylation 0.6905539255177555 1.788351436143106 0.0737193261800528 1.0 1.0 8 Q96ST2,Q12824 2 +Organic cation transport 0.7445766259237234 1.7808951924179213 0.0749295741675386 1.0 1.0 6 O43772 1 +Apoptotic process involved in development 0.7164032822933989 1.780064720448674 0.0750653694463689 1.0 1.0 7 Q12948,P20248,P30154 3 +Transcription initiation from rna polymerase ii promoter 0.6354221833070853 1.778016761281421 0.0754011020749665 1.0 1.0 22 Q14241,Q9H2U1,P11802,P50750,O75448,Q93074,Q15648,Q15369,Q9NPJ6,P19447,Q9Y6J9,Q9NVC6,P29083 13 +Myotube differentiation 0.6554443156219573 1.772470427357493 0.0763165000623977 1.0 1.0 15 Q9H7B4,Q9BYT8,P41440 3 +Hair follicle maturation 0.7766686246224377 1.7692360578406796 0.0768544891456224 1.0 1.0 5 P21359 1 +Regulation of rac protein signal transduction 0.7758879777135388 1.765920680785545 0.0774091570769326 1.0 1.0 5 P21359 1 +Response to ketone 0.5235880864822537 1.7630873187496872 0.0778857636974796 1.0 1.0 38 Q9H7B4,O95831,Q13126,P78330,P22681,P11802,Q13085 7 +T cell lineage commitment 0.7726011952977637 1.751952401413487 0.0797819929043022 1.0 1.0 5 P61586,P42345,P78527 3 +Peripheral nervous system development 0.6538744174307793 1.7451124630397965 0.0809652945622412 1.0 1.0 12 Q00535,P21266,Q13418,Q93074,P31751,Q9UPY3,P21359,P31749 8 +Regulation of modification of synaptic structure 0.8059210526315865 1.7439908951291865 0.0811606774928144 1.0 1.0 4 Q7L576,P61586,Q9UQB8 3 +Regulation of modification of postsynaptic structure 0.8059210526315865 1.7439908951291865 0.0811606774928144 1.0 1.0 4 Q7L576,P61586,Q9UQB8 3 +T cell homeostasis 0.7358116800208745 1.7422862170532067 0.0814583739720689 1.0 1.0 6 P31749,O95067 2 +Mesoderm morphogenesis 0.6807623919357454 1.7420471868751517 0.0815001877564669 1.0 1.0 8 P17612,Q12948 2 +Regulation of dna damage response signal transduction by p53 class mediator 0.6513055963590286 1.729546360686135 0.0837113566164728 1.0 1.0 11 O43324,Q9NRG4,P14174,Q9UNS2,O75844 5 +Vesicle tethering 0.7670588665053715 1.7283643462594114 0.0839229234315763 1.0 1.0 5 Q658Y4,O95772,Q14849 3 +Desmosome organization 0.920725406297073 1.7276413153998942 0.0840525507695439 1.0 1.0 3 P15924 1 +Excretion 0.7320081537108792 1.7254937466024618 0.0844385297826892 1.0 1.0 6 Q96PU5 1 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.7623998012917119 1.7085030333416078 0.0875430440261122 1.0 1.0 5 Q06520 1 +Positive regulation of actin cytoskeleton reorganization 0.7968307686227034 1.7066118424727073 0.0878942225572836 1.0 1.0 4 Q9UQB8,Q00535 2 +Positive regulation of actin filament polymerization 0.6433876656521746 1.702015602233495 0.0887524435218378 1.0 1.0 14 O95429,P16333,Q9UQB8,P61586,P42345,P35080,Q96J84 7 +Purine ribonucleoside metabolic process 0.6992511867749743 1.7016650341284745 0.0888181786474189 1.0 1.0 7 Q13126 1 +Cardiac chamber morphogenesis 0.6450691734859075 1.7006016370117572 0.0890178165649806 1.0 1.0 12 O94813,P20248,P15924,Q15648,Q12948,P62942 6 +Negative regulation of lipid transport 0.7938642384451804 1.6943928087484663 0.0901906651189128 1.0 1.0 4 P31751,P31749 2 +Deoxyribose phosphate catabolic process 0.6969981177245863 1.6913286591339056 0.0907740493364386 1.0 1.0 7 Q9H773 1 +Pyridine containing compound metabolic process 0.6969369173460427 1.691047771530099 0.0908276791140623 1.0 1.0 7 Q13126,P43490 2 +Ethanol catabolic process 0.9089309978818229 1.6832513352747664 0.0923264468409055 1.0 1.0 3 Q06520 1 +Primary alcohol catabolic process 0.9089309978818229 1.6832513352747664 0.0923264468409055 1.0 1.0 3 Q06520 1 +Regulation of oxidative phosphorylation 0.6417563263468324 1.682504695611147 0.0924710151572374 1.0 1.0 9 Q9BSK2 1 +Positive regulation of stem cell differentiation 0.7532957996486137 1.6696105510513335 0.0949964415073316 1.0 1.0 5 Q12948,Q9Y6C9,Q9H2U1 3 +Xenobiotic metabolic process 0.6389448834239255 1.6695470223341458 0.0950090195673527 1.0 1.0 12 Q06520,O15217,P07099,P21266 4 +Protein polyubiquitination 0.4387682875521624 1.6651812809435729 0.0958765943880322 1.0 1.0 45 O95376,P29144,Q9H1A4,P22681,Q96PU5,Q15386,Q13867,Q13951,Q96FW1,O00571,Q9UIQ6,O95071,Q96J02,P55786,P63208 15 +Peroxisomal transport 0.7520631862376312 1.6643366267775146 0.0960451768106893 1.0 1.0 5 P40855,O14678 2 +Schwann cell development 0.6379093835595908 1.6634728146297486 0.0962178282164654 1.0 1.0 9 Q00535,Q93074,P31751,Q9UPY3,P21359,P31749 6 +Rna secondary structure unwinding 0.7856923983574111 1.6606826524184142 0.0967771992713686 1.0 1.0 4 Q9H2U1 1 +Tricarboxylic acid metabolic process 0.6370509796269413 1.6577380973774831 0.0973703406253569 1.0 1.0 10 P50213,P48735 2 +Schwann cell differentiation 0.636415073272052 1.6545619738970814 0.0980133823485569 1.0 1.0 10 Q00535,Q93074,P31751,Q9UPY3,P21359,P31749 6 +Nucleoside triphosphate catabolic process 0.748420423938143 1.6487394372456938 0.0992010270212615 1.0 1.0 5 Q9H773 1 +Replication fork processing 0.6342595724937593 1.6453882854640265 0.0998897637889999 1.0 1.0 9 P50750,Q9Y3Z3,Q86V81 3 +Regulation of cellular response to heat 0.7118568605164305 1.6361589077358292 0.1018063340826245 1.0 1.0 6 Q9UHD1,Q99615,Q99543,P42345 4 +Positive regulation of neuron apoptotic process 0.630343808304362 1.6345152502733094 0.1021507067314859 1.0 1.0 14 P78362,O95831,P61586,Q00535,P21359 5 +Regulation of myotube differentiation 0.8958713143869254 1.6339781965589284 0.1022634288438371 1.0 1.0 3 Q9BYT8 1 +Regulation of ruffle assembly 0.6842140651744778 1.6325207084038895 0.1025698396481067 1.0 1.0 7 Q7L576,P35080,Q9P258 3 +Somatic diversification of immune receptors via somatic mutation 0.70739023545633 1.6162778265857445 0.1060342586473157 1.0 1.0 6 Q9UQ84,Q9Y3Z3 2 +Regulation of actin filament based movement 0.7062675163918857 1.6112762578024296 0.1071195231824417 1.0 1.0 6 P15924 1 +Regulation of heart rate 0.6277021663410771 1.6109633760111866 0.1071877051808531 1.0 1.0 10 P17612,P15924,P14923 3 +Regulation of oligodendrocyte differentiation 0.6790117738561325 1.6085151594503493 0.1077223987922308 1.0 1.0 7 P21359,P42345 2 +Regulation of fatty acid beta oxidation 0.8858927984215654 1.5962528209304503 0.1104323588581919 1.0 1.0 3 P31751,O00763 2 +Positive regulation of translational initiation 0.6246556290796098 1.5953796188112666 0.1106273708482752 1.0 1.0 11 Q13217,Q7Z739,O00571,Q07666,P42345 5 +Voluntary musculoskeletal movement 0.8846866205784798 1.5916885177402906 0.1114547095729234 1.0 1.0 3 P18887 1 +Response to epidermal growth factor 0.618066731572601 1.585629342020075 0.1128234160982133 1.0 1.0 16 P33993,O95429,P51452,Q9UQB8,Q12948,P31749 6 +Cardiac ventricle development 0.6191281391154245 1.5827873206577243 0.1134699476248943 1.0 1.0 15 O94813,P20248,P15924,Q15648,Q12948,P62942,O75844 7 +Positive regulation of histone ubiquitination 0.7658544913311313 1.5785609283096151 0.1144368025457933 1.0 1.0 4 P50750 1 +Deoxyribonucleoside triphosphate catabolic process 0.7628318287978546 1.5660154798752162 0.1173449932243242 1.0 1.0 4 Q9H773 1 +Mesoderm development 0.617995705651667 1.56276021770234 0.1181090046252466 1.0 1.0 12 P17612,Q12948 2 +Actin polymerization or depolymerization 0.4007160182278469 1.5614612243162382 0.1184149659552389 1.0 1.0 51 Q96F07,O95429,O94813,P16333,Q05655,Q9UQB8,P61586,O15511,Q13045,Q7L576,Q8N8S7,P42345,Q9NUQ9,P35080,Q96J84 15 +Fibroblast proliferation 0.6150381643108749 1.5612644118338763 0.118461376799019 1.0 1.0 15 Q7Z5K2,P11802,P14174,P21359,O75844 5 +Endoplasmic reticulum tubular network organization 0.6175751682299215 1.5601067661375831 0.1187346528946022 1.0 1.0 10 Q6DD88,Q9H6H4 2 +Nerve development 0.6425125453580053 1.5594370550941437 0.1188929717083426 1.0 1.0 8 Q9H061,Q9UPY3,Q13418 3 +Response to muscle stretch 0.7611525961597583 1.5590424413164998 0.1189863353383358 1.0 1.0 4 Q05397 1 +Inflammatory response to antigenic stimulus 0.6679653316647253 1.5574078483838305 0.1193736839476469 1.0 1.0 7 Q15046,P28070 2 +Calcium ion regulated exocytosis 0.6169389347581391 1.5569054170635797 0.1194929431418936 1.0 1.0 10 Q68EM7,Q9NVJ2 2 +Apoptotic process involved in morphogenesis 0.7264789488075072 1.5544640551201794 0.1200737642680458 1.0 1.0 5 Q12948,P30154 2 +Regulation of membrane depolarization 0.6930028912563729 1.552058665518203 0.1206481870776514 1.0 1.0 6 Q96PU5,Q8N335 2 +Positive regulation of cellular carbohydrate metabolic process 0.6923168785275655 1.548990038383836 0.1213841147689114 1.0 1.0 6 O75746,Q16531,P31751,P31749 4 +Positive regulation of glucose metabolic process 0.6923168785275655 1.548990038383836 0.1213841147689114 1.0 1.0 6 O75746,Q16531,P31751,P31749 4 +Positive regulation of glucose transmembrane transport 0.6921308301275131 1.5481577204940573 0.121584327930031 1.0 1.0 6 Q16625,P31751 2 +Peroxisome organization 0.640076958930405 1.5477239565002343 0.1216887716991175 1.0 1.0 8 P40855,O14678,Q7Z434 3 +Regulation of inflammatory response to antigenic stimulus 0.7248547829785006 1.5474647291470829 0.1217512231840565 1.0 1.0 5 Q15046,P28070 2 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.6657272763043989 1.5470320132374262 0.1218555263078915 1.0 1.0 7 Q96QE3,Q96K76 2 +Positive regulation of fibroblast proliferation 0.6651844353321218 1.544514310507313 0.1224637871642628 1.0 1.0 7 P11802,Q7Z5K2,P14174 3 +Regulation of cardiac muscle contraction 0.6139433315796385 1.5442503276554826 0.1225277009082086 1.0 1.0 9 P17612,P15924 2 +Ventricular cardiac muscle tissue morphogenesis 0.7234667956292493 1.5414811114739673 0.1231997365424812 1.0 1.0 5 P15924,Q12948,P62942 3 +Cardiac muscle tissue morphogenesis 0.7234667956292493 1.5414811114739673 0.1231997365424812 1.0 1.0 5 P15924,Q12948,P62942 3 +Muscle organ morphogenesis 0.7234667956292493 1.5414811114739673 0.1231997365424812 1.0 1.0 5 P15924,Q12948,P62942 3 +Positive regulation of translation in response to endoplasmic reticulum stress 0.756297178938861 1.5388668953428033 0.1238367944962202 1.0 1.0 4 O00571,Q13217 2 +Positive regulation of translation in response to stress 0.756297178938861 1.5388668953428033 0.1238367944962202 1.0 1.0 4 O00571,Q13217 2 +Regulation of actin filament length 0.4355382257264319 1.5366875435198255 0.1243698429415314 1.0 1.0 44 Q96F07,O95429,O94813,Q05655,Q9UQB8,P61586,O15511,Q13045,Q7L576,P42345,Q9NUQ9,P35080,Q96J84 13 +Negative chemotaxis 0.7549342105263194 1.533199945175686 0.1252265977817264 1.0 1.0 4 P06756,P61586,O94813 3 +Myelin maintenance 0.754031377225089 1.529445335832048 0.1261540807628871 1.0 1.0 4 P31751 1 +Dna dependent dna replication maintenance of fidelity 0.6109816104217501 1.5293816757630765 0.1261698524017283 1.0 1.0 13 Q07864,P50750,Q9Y3Z3,Q86V81,Q7Z7L1 5 +Positive regulation of oligodendrocyte differentiation 0.7536187487687407 1.5277291273514626 0.1265798051311248 1.0 1.0 4 P42345 1 +N terminal protein amino acid modification 0.6350517245405204 1.523527812385045 0.1276267079125943 1.0 1.0 8 Q9BXJ9,Q9BV86 2 +Neural precursor cell proliferation 0.5680845379800187 1.5204591052913972 0.1283956292938715 1.0 1.0 27 P48681,P43034,P61586,O75306,O95456,Q15154,P55209,P19022,P61026,Q9UBD5,P21359 11 +Deoxyribonucleoside triphosphate metabolic process 0.6857980629973695 1.5198025768651604 0.1285606012961559 1.0 1.0 6 Q9H773 1 +Cardiac muscle cell action potential involved in contraction 0.6083301808141568 1.5161744178165637 0.1294752549499462 1.0 1.0 9 P14923,P15924,Q96PU5 3 +Negative regulation of plasma membrane bounded cell projection assembly 0.6564772641337339 1.5040766897174436 0.1325616215340384 1.0 1.0 7 Q05655,P35080 2 +Muscle cell differentiation 0.422593346750664 1.5029979875281116 0.1328395629521144 1.0 1.0 62 Q9H7B4,Q92990,P41440,P26358,Q9BYT8,P50750,Q9BWF3,Q13045,Q7Z4V5,P19022,Q16527,O75844,Q08209,P31749,P42345,Q96PU8 16 +Inositol phosphate mediated signaling 0.7141333066193588 1.5011963830326225 0.1333047752116067 1.0 1.0 5 Q8IWX8,Q08209,P42345 3 +Calcineurin mediated signaling 0.7141333066193588 1.5011963830326225 0.1333047752116067 1.0 1.0 5 Q8IWX8,Q08209,P42345 3 +Cardiac ventricle morphogenesis 0.6556110879364675 1.5000486685278538 0.1336017961364535 1.0 1.0 7 P15924,Q12948,P62942 3 +Positive regulation of glucose import 0.7122361759465984 1.4929983659618684 0.1354376146323996 1.0 1.0 5 Q16625,P31751 2 +Protein deneddylation 0.6539095313701834 1.4921331271047569 0.1356642490073714 1.0 1.0 7 Q9UNS2,Q7L5N1,Q99627 3 +Cytokine production involved in inflammatory response 0.6535292823277895 1.4903637450440257 0.1361286198692792 1.0 1.0 7 Q53EL6,Q9BWS9,P40763,Q99496 4 +Histone h2a ubiquitination 0.6279644824294958 1.489339523616206 0.1363979849871635 1.0 1.0 8 Q96FW1,Q99496,Q6W2J9,O95071,P63208 5 +Protein localization to phagophore assembly site 0.8575082421902251 1.4886433205973664 0.1365813176359971 1.0 1.0 3 Q9Y4P8 1 +Aspartate family amino acid biosynthetic process 0.6008213453556793 1.474633279490597 0.1403111626843645 1.0 1.0 12 Q13126 1 +Collagen fibril organization 0.6003167479630955 1.4730233838443738 0.1407447305939779 1.0 1.0 10 Q12948 1 +Cellular response to ketone 0.588086369383147 1.4726284549994697 0.1408512477615144 1.0 1.0 20 Q9H7B4,O95831 2 +Regulation of actin cytoskeleton reorganization 0.6001569686415763 1.4722149155532438 0.140962850853096 1.0 1.0 10 Q9UQB8 1 +Cellular response to alcohol 0.5976663377891165 1.4695395656175902 0.1416864984532304 1.0 1.0 15 P14923,Q13085,P11802,O95831 4 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.5992034046874828 1.4673891680948663 0.1422702194188914 1.0 1.0 10 Q96K76,Q96QE3,P61978 3 +Regulation of membrane repolarization 0.7057569338765959 1.464976952180319 0.1429272060131712 1.0 1.0 5 Q96PU5 1 +Positive regulation of endothelial cell proliferation 0.598902189796986 1.4644720950272578 0.1430650021355273 1.0 1.0 11 Q96EB6,P40763,P09429,P21359,Q9H2J4,P09601,P31749,O75340 8 +Regulation of glucose import 0.5959376136500001 1.454005670745829 0.1459447340073492 1.0 1.0 9 Q16625,P31751 2 +Regulation of notch signaling pathway 0.6711008715127129 1.4538253583301908 0.1459947310809632 1.0 1.0 6 Q15334,P57105,P31749 3 +Negative regulation of inflammatory response to antigenic stimulus 0.8480981328118283 1.452895094482704 0.1462528831862291 1.0 1.0 3 P28070 1 +Regulation of behavior 0.6703014379261041 1.4502303747840368 0.1469942873753091 1.0 1.0 6 Q15334,P40763,P42345 3 +Protein localization to ciliary membrane 0.7014482945904545 1.4463246280893636 0.1480861711785854 1.0 1.0 5 Q96A65,Q9NQ48,Q15276 3 +Regulation of organ growth 0.5940196509733427 1.4443628669711766 0.1486369302332735 1.0 1.0 9 Q12948,O00763 2 +Response to chemokine 0.7327740935461262 1.440876821265288 0.1496194854326569 1.0 1.0 4 Q12948,P61586 2 +Regulation of glycogen metabolic process 0.6991679049631823 1.4364472063795652 0.1508751286611711 1.0 1.0 5 P31751 1 +Regulation of glucan biosynthetic process 0.6991679049631823 1.4364472063795652 0.1508751286611711 1.0 1.0 5 P31751 1 +Regulation of lyase activity 0.6167861325676522 1.4352759373713284 0.15120848184622 1.0 1.0 8 P21359 1 +Deoxyribose phosphate metabolic process 0.5927273689436897 1.4329435818188756 0.1518739611164434 1.0 1.0 12 Q9H773,P34896 2 +Embryonic brain development 0.6409087777991165 1.4315427843211894 0.1522747141896947 1.0 1.0 7 P27635,O60508,Q93074 3 +Regulation of mitochondrial gene expression 0.5910088707156873 1.4292150960954564 0.1529424200872216 1.0 1.0 9 P34897,Q9BSH4,Q567V2 3 +Positive regulation of muscle hypertrophy 0.6973424076705588 1.4285375351425786 0.1531371988609167 1.0 1.0 5 P50750 1 +Mitochondrion localization 0.5883188813387847 1.4268710269914835 0.1536170734510955 1.0 1.0 16 O75153,Q9BUK6 2 +Positive regulation of deoxyribonuclease activity 0.7288345927431423 1.4244330108062504 0.1543211640308612 1.0 1.0 4 P31749 1 +Glyoxylate metabolic process 0.8390486691064388 1.4184948349753947 0.1560463455816729 1.0 1.0 3 P48735 1 +Regulation of keratinocyte migration 0.7273619205754671 1.4182840002637267 0.1561078659829995 1.0 1.0 4 Q15555 1 +Keratinocyte migration 0.7273619205754671 1.4182840002637267 0.1561078659829995 1.0 1.0 4 Q15555 1 +Histone h2a monoubiquitination 0.6945242621431883 1.416322507209457 0.1566811009958135 1.0 1.0 5 P63208,Q99496,Q6W2J9 3 +Cellular response to insulin stimulus 0.3936272771574971 1.4137063957580431 0.1574481266894165 1.0 1.0 54 P11802,Q9UQB8,O14654,Q92572,P31751,P61026,Q7L576,P78527,P49815,Q9BSK2,P43490 11 +Positive regulation of dendritic spine development 0.5876289260140894 1.412194985463655 0.1578925566079234 1.0 1.0 9 P43034,Q9H2U1,Q9UQB8 3 +Peroxisome proliferator activated receptor signaling pathway 0.6610641104544217 1.40864951354353 0.158938830290698 1.0 1.0 6 Q15648,O43707,Q15120 3 +Stress granule assembly 0.5864292583519682 1.4050343399243443 0.1600110671178267 1.0 1.0 14 P62266,Q7Z739,O00571,Q14011,Q9Y520 5 +Striated muscle cell differentiation 0.4497834279450465 1.4034580262749488 0.1604803000692833 1.0 1.0 41 Q9H7B4,P41440,Q9BYT8,Q13045,Q16527,O75844,P31749,P42345 8 +Peripheral nervous system myelin maintenance 0.8339245317992872 1.399009544762584 0.1618101208551583 1.0 1.0 3 P31751 1 +Actin mediated cell contraction 0.5843076130160908 1.3987104550702931 0.1618998277385337 1.0 1.0 15 P15924,Q96PU5,Q9UM22,Q8N335,P14923 5 +Endochondral bone morphogenesis 0.6584353919264843 1.3968036716552434 0.1624726178850846 1.0 1.0 6 Q12948 1 +L serine metabolic process 0.6873813288562981 1.3853405439458624 0.165948361897972 1.0 1.0 5 P78330,P34897 2 +Cell junction disassembly 0.7193860833032005 1.384965452466738 0.1660630314095961 1.0 1.0 4 Q15555,P51452 2 +Regulation of tube size 0.5821801346877173 1.3810238753357789 0.1672716197868926 1.0 1.0 10 Q9HB40,Q12948 2 +Positive regulation of wound healing 0.5818562758436543 1.3793772095633428 0.1677784822847197 1.0 1.0 10 Q05397,Q16625,P42345 3 +Regulation of neurotransmitter transport 0.5814776315391572 1.3760615629205548 0.1688025742940531 1.0 1.0 13 P21359,P41440 2 +Regulation of dna primase activity 0.6850593793736566 1.3752632945078545 0.1690498317213871 1.0 1.0 5 Q14691,Q9Y248 2 +Negative regulation of fatty acid oxidation 0.8253919900981255 1.366557646382535 0.1717640003440637 1.0 1.0 3 O00763 1 +Cellular modified amino acid metabolic process 0.3863471245377881 1.3659366159947763 0.1719588587290452 1.0 1.0 53 Q9NRX5,O60725,Q8WUX2,P41440,P34897,Q9UHG3,P21266,Q06520,O15217,O75874,Q9NRN7 11 +Positive regulation by host of viral transcription 0.626500078039666 1.3641895238618411 0.1725079244865783 1.0 1.0 7 P50750,Q12824 2 +Heart valve morphogenesis 0.7143589109641695 1.3639530054897389 0.1725823567376476 1.0 1.0 4 P20248,P42345 2 +Folic acid containing compound metabolic process 0.5789145147327355 1.362690471961852 0.172980081947881 1.0 1.0 13 P41440,P34897,Q9H2D1,Q8IYS1,Q9NRN7,P34896 6 +Negative regulation of epidermal growth factor activated receptor activity 0.8242456878632461 1.362197688954497 0.1731355049816851 1.0 1.0 3 P22681 1 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.8237421900690568 1.3602826374949704 0.1737405005662589 1.0 1.0 3 O60678,Q86X55 2 +Long chain fatty acid transport 0.5776707794805229 1.3589431616209438 0.1741646003515085 1.0 1.0 14 P23786,O43772,P31751,O14678,P31749 5 +Positive regulation of dendritic spine morphogenesis 0.6249535804352631 1.3569498732545675 0.1747971384251809 1.0 1.0 7 Q9H2U1,Q9UQB8 2 +Cellular modified amino acid catabolic process 0.649380779492931 1.3559626890891598 0.1751110396837245 1.0 1.0 6 Q9UHG3,Q9NRN7 2 +3 utr mediated mrna destabilization 0.6493056248375341 1.3556234787888402 0.1752189975990328 1.0 1.0 6 Q92945,Q9H2U1,Q9HCE1,Q13148 4 +Tetrahydrofolate interconversion 0.6804744292202454 1.3553572108778302 0.1753037754738449 1.0 1.0 5 P34897 1 +G quadruplex dna unwinding 0.7121761568970352 1.3548273474004082 0.1754725714085281 1.0 1.0 4 Q9H2U1,P22626 2 +Signal transduction in response to dna damage 0.3944228109524516 1.3541563109575816 0.1756865140721393 1.0 1.0 46 Q96QE3,O43324,Q9NRG4,P24941,Q96RU2,Q6NUQ1,P14174,P78527,Q9UNS2,O75844 10 +Protein localization to chromosome centromeric region 0.5765820699201117 1.352543768437891 0.1762014270902869 1.0 1.0 10 P50748,Q8IY18,Q96DY7 3 +Detection of muscle stretch 0.8213069014411634 1.3510200984039922 0.1766889945838727 1.0 1.0 3 Q05397 1 +Water soluble vitamin metabolic process 0.5631057881918542 1.3478878075775382 0.1776944701479301 1.0 1.0 21 P41440,P34897,Q96RQ3,O14678,P50747,Q9NRN7 6 +Regulation of histone h2b ubiquitination 0.8203198613906184 1.3472659851593023 0.1778945829995344 1.0 1.0 3 P50750 1 +Neural tube patterning 0.6780579982691334 1.3448624654068382 0.1786696534267071 1.0 1.0 5 P17612,O75787 2 +Heart valve development 0.6457016071290779 1.3393529217082245 0.180455807840552 1.0 1.0 6 P20248,P42345 2 +Dendritic spine morphogenesis 0.5735168214707452 1.337056693388642 0.1812041317830559 1.0 1.0 14 P43034,Q9H2U1,O60678,Q00535,Q9UQB8,Q15334 6 +Ruffle assembly 0.5735901777681365 1.3348652796453115 0.1819204432521539 1.0 1.0 11 Q7L576,P35080,O95429 3 +Regulation of granulocyte chemotaxis 0.5720857739253745 1.333742498534465 0.1822882616290204 1.0 1.0 9 Q05397,Q07021,Q8NE86 3 +Regulation of dna methylation 0.5719097433278666 1.332852465890767 0.1825802242329559 1.0 1.0 9 Q8NB78 1 +Tetrahydrofolate metabolic process 0.5718788307515019 1.3326961648777516 0.1826315323352367 1.0 1.0 9 P34897,Q9NRN7 2 +Sterol biosynthetic process 0.5603292112373647 1.332097453819174 0.1828281669263503 1.0 1.0 21 Q15392,Q16850,Q14739 3 +Spinal cord development 0.571602130333303 1.326963552957166 0.1845207394634496 1.0 1.0 14 P21359,P98155,Q93074 3 +Regulation of calcineurin mediated signaling 0.704235874117639 1.3216223685269353 0.1862939310022695 1.0 1.0 4 Q8IWX8,P42345 2 +Serine family amino acid catabolic process 0.8126274619604354 1.3180114663543874 0.1874998095096174 1.0 1.0 3 P34897 1 +Macrophage chemotaxis 0.6405109973748916 1.3159076379910009 0.1882050448377996 1.0 1.0 6 Q05397 1 +Macrophage migration 0.6405109973748916 1.3159076379910009 0.1882050448377996 1.0 1.0 6 Q05397 1 +Nephron morphogenesis 0.7021896578978787 1.3130640042596773 0.1891613818764415 1.0 1.0 4 Q9BRK4,Q13418 2 +Histone arginine methylation 0.8102597829661287 1.3090086604630156 0.1905314171339263 1.0 1.0 3 Q99873,Q86X55 2 +Cellular response to prostaglandin e stimulus 0.8102208813902689 1.3088607503733318 0.190581524007888 1.0 1.0 3 Q13085 1 +Response to prostaglandin e 0.8102208813902689 1.3088607503733318 0.190581524007888 1.0 1.0 3 Q13085 1 +Histone h3 deacetylation 0.6684398650970106 1.3030714879051135 0.1925503566185149 1.0 1.0 5 Q9H4L7,P23246 2 +Regulation of protein folding 0.6986634426734903 1.2983148826738995 0.1941791543351216 1.0 1.0 4 O14737,P08621 2 +Peptidyl arginine n methylation 0.6365938425167108 1.2982064680365124 0.19421639611955 1.0 1.0 6 Q99873,O60678,Q86X55,Q6P2P2 4 +Peptidyl arginine methylation 0.6365938425167108 1.2982064680365124 0.19421639611955 1.0 1.0 6 Q99873,O60678,Q86X55,Q6P2P2 4 +Corpus callosum development 0.8069713909898029 1.2965067525336147 0.1948009551724367 1.0 1.0 3 Q96P11,P43034 2 +Trabecula morphogenesis 0.8059848733969097 1.292756652551702 0.1960952369409274 1.0 1.0 3 P61586,P62942 2 +Fatty acid transport 0.5632481427097963 1.2922281427333315 0.1962781483146842 1.0 1.0 16 P23786,O43772,P31751,O43808,O14678,P31749 6 +Positive regulation of rna binding 0.6343333107332667 1.2879888131737571 0.1977498573527594 1.0 1.0 6 Q06787,O15371,P50750,P60228 4 +Organic acid transport 0.4170455868091224 1.2856036879482766 0.1985814090040982 1.0 1.0 43 P23786,P41440,O43772,Q9H2D1,Q96NB2,P31751,O43808,O14678,P14174,Q7L0J3,P21359,P31749 12 +Response to testosterone 0.5632239275011836 1.281593848842605 0.1999851591055721 1.0 1.0 11 Q13126,P78330 2 +Cell substrate adhesion 0.3775135588685939 1.2774106620051693 0.201457302541492 1.0 1.0 53 Q9Y2S7,Q7Z460,P07942,Q07021,P51452,P61586,P21359,P36404,Q05397,O15144,P20248,Q9P258,Q00535,P46939,Q13418,P60953,P62820,P14923,Q9H2G2,P06756,O43707,Q9UM22,Q9Y251 23 +Regulation of striated muscle contraction 0.5617053993774 1.2767110735872036 0.2017042705030631 1.0 1.0 10 P17612,P15924 2 +Dna templated transcription termination 0.6068968001256683 1.2723071073041432 0.2032640243274988 1.0 1.0 7 Q16637,O75844,Q9H0D6 3 +Primary mirna processing 0.6613509404752066 1.272257719054985 0.2032815658345237 1.0 1.0 5 P22626,O00571 2 +Protein localization to cilium 0.5613567197967536 1.2719900620233369 0.2033766502880389 1.0 1.0 11 Q96A65,Q9NQ48,A0AVF1,Q15276 4 +Endocrine process 0.6921042660423623 1.2708800795619213 0.2037713142221475 1.0 1.0 4 O75787 1 +Protein heterotetramerization 0.6065195917023313 1.2705371732060984 0.2038933501922986 1.0 1.0 7 O43809,P31350,Q16630,P23921,Q9NSD9,Q9Y285 6 +Regulation of vascular permeability 0.6060187998897315 1.2681872833175691 0.2047310772200083 1.0 1.0 7 Q16625,Q9UDY2 2 +Positive regulation of hematopoietic progenitor cell differentiation 0.7994080894442492 1.267762851347119 0.2048826521365074 1.0 1.0 3 Q12948,Q9H2U1 2 +Glycine biosynthetic process 0.7987504110489864 1.2652642237752545 0.2057766267899685 1.0 1.0 3 P34897,P34896 2 +Negative regulation of epithelial cell migration 0.5594139279264557 1.2650151459757 0.2058658985082777 1.0 1.0 10 P57105,O94813,P61586,P35080,P14923 5 +Regulation of production of small rna involved in gene silencing by rna 0.604836926159575 1.262641178744185 0.2067181620051319 1.0 1.0 7 Q13546,O75844,Q08209 3 +Cardiac muscle cell contraction 0.5591027025419955 1.2603939968204592 0.2075272661903653 1.0 1.0 11 P14923,P15924,Q96PU5 3 +Radial glial cell differentiation 0.7974350542584636 1.260267434512921 0.20757290354802 1.0 1.0 3 P19022,P61586 2 +T cell selection 0.7974350542584598 1.260267434512908 0.2075729035480247 1.0 1.0 3 P61586,P42345 2 +Regulation of establishment of planar polarity 0.6041975715077271 1.2596407305180608 0.2077989952874515 1.0 1.0 7 O95487,P61586,Q93074 3 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.5415058869802799 1.2591944606615093 0.2079601018686132 1.0 1.0 23 P24390,Q9Y282,O14579,P42858,Q12907,P53621,Q6NUQ1,P35606,Q92538,O43731,Q9H4A5 11 +Regulation of signal transduction by p53 class mediator 0.4794756428466898 1.258241387670623 0.2083044712121711 1.0 1.0 35 O14744,P61978,O43324,Q9NRG4,Q96QE3,P17844,P61927,P14174,Q9UNS2,O75844,P31749,P42345 12 +Regulation of macrophage chemotaxis 0.68810586683486 1.2541581550407574 0.2097845259943622 1.0 1.0 4 Q05397 1 +Regulation of macrophage migration 0.68810586683486 1.2541581550407574 0.2097845259943622 1.0 1.0 4 Q05397 1 +Regulation of histone ubiquitination 0.556303929131764 1.2538411718439262 0.2098997409816088 1.0 1.0 9 Q96FW1,P50750,Q6PD62 3 +Negative regulation of gliogenesis 0.6570793336196354 1.2536883682272877 0.2099552974051204 1.0 1.0 5 P21359 1 +Manganese ion transmembrane transport 0.7954620190726724 1.2527734805637054 0.210288155440208 1.0 1.0 3 Q15043,Q9HD20 2 +Manganese ion transport 0.7954620190726724 1.2527734805637054 0.210288155440208 1.0 1.0 3 Q15043,Q9HD20 2 +Negative regulation of protein localization 0.4224611212091933 1.2525012977533494 0.2103872557306561 1.0 1.0 42 Q9HD26,Q96ST3,O95429,Q16836,Q96PU5,Q96CW1,Q6GQQ9,Q9BRK4,P21359,Q16850,Q08209,Q9NQ48,P31689 13 +Mismatch repair 0.5578110958521846 1.2522565670011745 0.2104763897247517 1.0 1.0 12 Q9UQ84 1 +Negative regulation of protein localization to nucleus 0.6026128639820053 1.2522032813527697 0.2104958006446708 1.0 1.0 7 Q6GQQ9,P21359,Q96ST3 3 +Arf protein signal transduction 0.687608063400205 1.2520764494880972 0.2105420082238236 1.0 1.0 4 Q15555 1 +Interleukin 6 mediated signaling pathway 0.7951331798750368 1.251524638767504 0.2107431301744087 1.0 1.0 3 P40763,Q6PD62 2 +Regulation of organic acid transport 0.556638152489363 1.250843068061028 0.2109917383680777 1.0 1.0 10 Q7L0J3,P31751,P31749 3 +C terminal protein amino acid modification 0.7947890388195056 1.2502177323220085 0.2112200209380477 1.0 1.0 3 Q9Y4P8 1 +Positive regulation of neuron differentiation 0.5784659096738418 1.2489540163680226 0.2116818930715851 1.0 1.0 8 Q99829,Q96ST3,P61586,Q92974 4 +Regulation of neuron projection arborization 0.7944095071631034 1.248776484157232 0.2117468372757065 1.0 1.0 3 Q9HCE1 1 +Skeletal muscle adaptation 0.7943244709709455 1.2484535727565227 0.2118650004957643 1.0 1.0 3 Q13555 1 +Regulation of skeletal muscle adaptation 0.7943244709709455 1.2484535727565227 0.2118650004957643 1.0 1.0 3 Q13555 1 +Negative regulation of axonogenesis 0.6246809766615622 1.244345193874679 0.2133725445059142 1.0 1.0 6 Q8N0X7,Q00535 2 +Erythrocyte development 0.6246476171493737 1.2441943290643112 0.2134280503974237 1.0 1.0 6 Q15648,P18074,P62753 3 +Maintenance of dna methylation 0.6855263157894819 1.243371594723431 0.213730932609109 1.0 1.0 4 P26358,Q9NRZ9,Q93009 3 +Purine containing compound transmembrane transport 0.5759444572877016 1.236659173887958 0.2162136414687894 1.0 1.0 8 P41440 1 +Regulation of histone h4 k16 acetylation 0.6529789346563333 1.235863855347369 0.2165091743516605 1.0 1.0 5 Q12824 1 +Protein heterooligomerization 0.574486644350752 1.229549767092855 0.2188657506315401 1.0 1.0 8 O43809,P31350,Q16630,P23921,Q9NSD9,Q9Y285 6 +Protein transmembrane import into intracellular organelle 0.5531712387649722 1.2281794814389753 0.2193795994313814 1.0 1.0 12 O60830,O95831 2 +Muscle organ development 0.5003670571535884 1.2276828192549478 0.2195660584139638 1.0 1.0 31 P60660,Q14331,P41440,Q9BYT8,P17844,P15924,P61586,P46939,P51114,Q13642,Q00535,Q15648,Q12948,P62942,P21359,Q08209 16 +Intermediate filament based process 0.5519215262431008 1.2267528403440666 0.2199155008254592 1.0 1.0 10 P48681,P48729,P15924,Q16352,P58107 5 +Transcription coupled nucleotide excision repair 0.6813584757322109 1.2259470234391667 0.2202186115404654 1.0 1.0 4 P18074,P19447 2 +Mammary gland epithelium development 0.5503986515704592 1.223900397763093 0.2209898035565034 1.0 1.0 9 P31751,P31749 2 +Humoral immune response mediated by circulating immunoglobulin 0.7877757444132378 1.2235957804809396 0.2211047521634688 1.0 1.0 3 Q9UQ84 1 +Positive regulation of lipid kinase activity 0.6803213785625428 1.221612029918926 0.2218543771991781 1.0 1.0 4 Q05397,P60953 2 +Tyrosine phosphorylation of stat protein 0.6795677724443607 1.2184622417834727 0.2230483649247769 1.0 1.0 4 P22059 1 +Intracellular lipid transport 0.5511116527385194 1.2173267258189508 0.2234799296964371 1.0 1.0 13 P23786,Q9NVJ2,O43772,O14678 4 +Pons development 0.7860894844330744 1.217198532692144 0.2235286883369678 1.0 1.0 3 O95487 1 +Cellular response to leucine starvation 0.7849391647484291 1.212835412778687 0.2251927531321458 1.0 1.0 3 Q9P2J5,P42345 2 +Trna 5 leader removal 0.678089122897051 1.212282653802767 0.2254042015342419 1.0 1.0 4 Q99575 1 +Regulation of glucose transmembrane transport 0.5500244841444756 1.211846619878124 0.225571098785021 1.0 1.0 12 Q16625,P31751 2 +Regulation of osteoblast differentiation 0.5485715051969999 1.2096372564077336 0.2264181155199149 1.0 1.0 10 P17612,Q05397,P20248,Q13418 4 +Regulation of protein localization to cell surface 0.5490791759281438 1.2087988542334656 0.2267401319003457 1.0 1.0 11 Q9HD26,Q96PU5,Q8N335,Q92538,P31749 5 +Response to potassium ion 0.6768375659202432 1.2070528043505298 0.2274118089250336 1.0 1.0 4 Q14168 1 +Cellular response to potassium ion 0.6768375659202432 1.2070528043505298 0.2274118089250336 1.0 1.0 4 Q14168 1 +Protein destabilization 0.546545706275316 1.204357199151266 0.2284515474382986 1.0 1.0 9 Q96EB6,P42858,P19474,P78527,P53350 5 +Regulation of gliogenesis 0.5485111692050718 1.2037129751510425 0.2287005354878759 1.0 1.0 13 P21359,Q9UPY3,P42345,Q96G23 4 +Regulation of mrna binding 0.5915040575143037 1.2000535743343137 0.2301185343349803 1.0 1.0 7 P50750,P60228,Q86X55 3 +Regulation of polysaccharide metabolic process 0.6143367125531395 1.1975634030987383 0.2310870305942007 1.0 1.0 6 P31751 1 +Positive regulation of neuron death 0.5411701509439454 1.197387017019029 0.2311557416720471 1.0 1.0 19 P78362,O95831,P61586,Q00535,P21359 5 +Regulation of cysteine type endopeptidase activity 0.3644492004800596 1.196246693902621 0.2316003040218757 1.0 1.0 51 Q15392,O95831 2 +Plasma membrane organization 0.5009613192992691 1.1956192522698956 0.2318451750038022 1.0 1.0 30 Q96CP7,Q9UQB8,Q9NVJ2,P41440 4 +Negative regulation of nik nf kappab signaling 0.7803761081204563 1.1955356796624823 0.2318778046645233 1.0 1.0 3 Q99829 1 +Regulation of blood brain barrier permeability 0.7790012110844752 1.1903256871549384 0.2339184084469148 1.0 1.0 3 Q16625 1 +Positive regulation of vascular permeability 0.7790012110844752 1.1903256871549384 0.2339184084469148 1.0 1.0 3 Q16625 1 +Positive regulation of blood brain barrier permeability 0.7790012110844752 1.1903256871549384 0.2339184084469148 1.0 1.0 3 Q16625 1 +Negative regulation of production of mirnas involved in gene silencing by mirna 0.7789514833805333 1.1901372743108047 0.233992442020968 1.0 1.0 3 O75844 1 +Negative regulation of i kappab kinase nf kappab signaling 0.5658950104782167 1.1876410279168537 0.234974866513129 1.0 1.0 8 P42224,P61586,Q6GQQ9,Q13546,O60826 5 +Membrane repolarization 0.5885436218297249 1.1861549029443756 0.2355611319297692 1.0 1.0 7 Q96PU5 1 +Cell cell adhesion mediated by cadherin 0.5881821091268064 1.1844577186128546 0.2362319238950752 1.0 1.0 7 P19022,P41440 2 +Dendrite development 0.3755245577908063 1.1750358599092567 0.2399803694557325 1.0 1.0 46 P98155,P43034,Q9H2U1,Q9UQB8,O60678,Q86X55,P61586,Q96PU5,Q00535,P60953,Q15334,Q7L576,O43815,O60828,Q08209 15 +Muscle cell development 0.5067211115969104 1.1690683362749992 0.2423760999233006 1.0 1.0 28 Q9H7B4,O75844,Q16527,P42345 4 +Hypothalamus development 0.6078809621444613 1.16837384179893 0.2426560015955812 1.0 1.0 6 O14949 1 +Negative regulation of chemotaxis 0.637241621966224 1.167486303367684 0.2430140363837396 1.0 1.0 5 P51452,P14174 2 +Intracellular protein transmembrane transport 0.533336170721886 1.165168783274801 0.2439506789340289 1.0 1.0 20 P31751,O60830,O95831 3 +Positive regulation of cilium assembly 0.6366958616839324 1.165116652838307 0.2439717769465472 1.0 1.0 5 Q15555,P42858 2 +Ruffle organization 0.5406671681424359 1.163646271236633 0.2445673915526773 1.0 1.0 14 Q7L576,P35080,O95429,P42345 4 +Regulation of mitochondrial membrane potential 0.5350653857220643 1.163464100828788 0.2446412552057948 1.0 1.0 19 Q9BSK2,P31751,Q8N0X7,P28331 4 +Dsrna processing 0.5306475517244146 1.163193550358434 0.2447509827401675 1.0 1.0 21 Q9UGR2,P40763,Q13546,P22626,O00571,Q9UPY3,O75844,Q08209 8 +Protein kinase c signaling 0.6662551214320092 1.162862920772214 0.2448851235388138 1.0 1.0 4 P41440 1 +Regulation of glial cell differentiation 0.5395082009781874 1.1595127151519176 0.246247256682722 1.0 1.0 11 P21359,Q9UPY3,P42345 3 +Positive regulation of nuclease activity 0.6351912996684097 1.1585847510589176 0.2466254875298754 1.0 1.0 5 P31749 1 +Serine family amino acid biosynthetic process 0.559750279281384 1.1576653119260694 0.2470006449447992 1.0 1.0 8 P78330,P34897 2 +Inner cell mass cell proliferation 0.6054343683228267 1.157314718100821 0.2471438024475589 1.0 1.0 6 Q14691 1 +Regulation of fatty acid transport 0.634866466548079 1.1571746804467806 0.2472010000707267 1.0 1.0 5 P31751,P31749 2 +Regulation of sodium ion transmembrane transport 0.5378614642015312 1.1549043177189835 0.2481296110951276 1.0 1.0 10 Q9UHD1,Q96PU5,P46939,O43707,Q8N335 5 +Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.6643331340334802 1.1548442872520044 0.2481541974973879 1.0 1.0 4 Q96QE3 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.6031893668989583 1.147168870653282 0.2513118344379439 1.0 1.0 6 Q96QE3,P61978 2 +Cellular process involved in reproduction in multicellular organism 0.3568705033051841 1.1450564416417857 0.2521857776073766 1.0 1.0 50 P17612,Q14997,Q8NB78,P62753,P30153,O94813,P43034,Q96PU8,A0AVF1,Q96MU7,Q12948,Q92879,P31749,P42345,O95067 15 +Negative regulation of establishment of protein localization 0.5241466875806831 1.1409795667361804 0.2538784262073958 1.0 1.0 22 P21359,Q9HD26,Q16850,O95429 4 +Signal transduction by p53 class mediator 0.3715847642815565 1.1378490809388024 0.2551835063721281 1.0 1.0 46 O14744,P61978,O43324,Q9NRG4,Q96QE3,Q96RU2,P17844,P61927,P14174,Q9UNS2,O75844,P31749,P42345 13 +Cellular response to steroid hormone stimulus 0.3606174322342101 1.1332390133316417 0.2571138948845224 1.0 1.0 52 Q9H7B4 1 +Regulation of glial cell proliferation 0.6590901087617376 1.1329839217255249 0.2572210053371431 1.0 1.0 4 Q96G23 1 +Cytochrome complex assembly 0.5336883540932247 1.1295466796913518 0.2586672894847064 1.0 1.0 11 Q9BSH4,Q9BSK2,Q6DKK2,Q7KZN9 4 +Positive regulation of toll like receptor signaling pathway 0.6275790970605575 1.1255579430944669 0.2603526782495455 1.0 1.0 5 P41440 1 +Regulation of rna binding 0.5303266861180622 1.122065232483078 0.2618347051124465 1.0 1.0 9 P50750,P60228,Q86X55 3 +Vitamin transport 0.5309303473287794 1.1194866721062224 0.2629325736428751 1.0 1.0 10 Q9H2D1,O14678,P41440 3 +Phosphorylation of rna polymerase ii c terminal domain 0.6253749595813092 1.1160025018276167 0.264421063704807 1.0 1.0 5 P50750 1 +Renal water homeostasis 0.7588773464435105 1.114240674887148 0.2651759500369348 1.0 1.0 3 P17612 1 +Positive regulation of mitochondrial translation 0.6249053023793071 1.1139669291870566 0.2652933744203281 1.0 1.0 5 Q567V2 1 +Response to corticosteroid 0.4971730188070768 1.109252605451474 0.267321224597167 1.0 1.0 28 Q9H7B4 1 +Proton transporting two sector atpase complex assembly 0.623264938764914 1.106858765494711 0.268354996085355 1.0 1.0 5 Q92544,Q5TC12,Q8N511 3 +Negative regulation of organic acid transport 0.7563010203332157 1.1045277049877995 0.2693642922787473 1.0 1.0 3 P31751 1 +Pteridine containing compound metabolic process 0.527283879519668 1.1040812129291802 0.2695579100752017 1.0 1.0 17 P00374,P41440,P34897,Q9H2D1,Q8IYS1,Q9NRN7,P34896 7 +Regulation of histone h3 k36 methylation 0.6516791522324141 1.1021247435907866 0.2704074435634656 1.0 1.0 4 Q96ST2 1 +Dna damage response signal transduction by p53 class mediator 0.5277515867382387 1.1012012941356482 0.2708090586033851 1.0 1.0 16 P14174,O75844,O43324,Q9NRG4 4 +Pyridine containing compound biosynthetic process 0.6514273700650173 1.101077258668518 0.2708630336772242 1.0 1.0 4 P43490 1 +Response to hydroxyurea 0.6219151036525099 1.101011297428527 0.2708917402666442 1.0 1.0 5 Q5TDH0,Q9BY42,Q06787,O95251 4 +Negative regulation of kinase activity 0.3576692499120554 1.1002058059155475 0.2712424615092352 1.0 1.0 47 Q9H7B4,Q53EL6,O95684,P22681,P51452,Q05655,P21359,P49815,P31749,Q99816,P31689 11 +Regulation by virus of viral protein levels in host cell 0.6499705632157331 1.0950178373662482 0.2735088219748889 1.0 1.0 4 Q16531,P42224 2 +Positive regulation of peptidyl tyrosine phosphorylation 0.5262680177339946 1.093228799802738 0.2742933551313466 1.0 1.0 16 Q15334,P22059,P42345 3 +Hair cell differentiation 0.5464353269899458 1.0927426878258313 0.2745067914967021 1.0 1.0 8 P18074,O95487,P19447 3 +Regulation of defense response to virus by host 0.5685105257469112 1.092166495159432 0.2747599263156055 1.0 1.0 7 O60828,Q96ST3,Q7Z434 3 +Bone morphogenesis 0.5676322007752003 1.0880504986485855 0.2765728149125042 1.0 1.0 7 Q12948 1 +Protein transmembrane transport 0.5086709732416386 1.0856253759280892 0.277644768182522 1.0 1.0 24 P31751,O60830,O95831,Q9NS69 4 +Steroid catabolic process 0.6467576294510258 1.0816622203122583 0.2794026461853611 1.0 1.0 4 Q15036 1 +Regulation of dendritic spine morphogenesis 0.5238813391574796 1.0790819140965122 0.2805512129484118 1.0 1.0 11 P43034,Q9H2U1,Q9UQB8 3 +Response to xenobiotic stimulus 0.3885608776584862 1.0777906594456297 0.2811271888766913 1.0 1.0 66 P07099,Q16836,Q86WA6,P50750,P21266,Q06520,O15217,O00763,P18887 9 +Positive regulation of dendritic cell cytokine production 0.6162918285777237 1.0766700176245034 0.2816277115551591 1.0 1.0 5 Q9H2U1,Q7Z434 2 +Myeloid dendritic cell cytokine production 0.6162918285777237 1.0766700176245034 0.2816277115551591 1.0 1.0 5 Q9H2U1,Q7Z434 2 +Positive regulation of myeloid leukocyte mediated immunity 0.6162918285777237 1.0766700176245034 0.2816277115551591 1.0 1.0 5 Q9H2U1,Q7Z434 2 +Dendritic cell cytokine production 0.6162918285777237 1.0766700176245034 0.2816277115551591 1.0 1.0 5 Q9H2U1,Q7Z434 2 +Regulation of sodium ion transport 0.5241225509227037 1.0761026887287728 0.2818813333238088 1.0 1.0 13 Q9UHD1,O43865,Q96PU5,P46939,O43707,Q8N335,P31749 7 +Positive regulation of erbb signaling pathway 0.5862923013585395 1.0709023810795175 0.2842133251420753 1.0 1.0 6 P37198,P22681,P27695 3 +Protein k29 linked ubiquitination 0.7471042094460985 1.069917894226317 0.284656267775522 1.0 1.0 3 Q15386 1 +Peptidyl serine modification 0.385198981623965 1.0680868743048546 0.2854813260695208 1.0 1.0 65 Q9H7B4,O95429,P24941,P16333,Q10471,Q9BV86,P17612,P78362,P48729,P31751,P78527,P35080,Q86UE8,Q00535,Q13418,P14174,P31749,Q8IV63,Q05655,Q13546,Q15120,Q8N335,P42345 23 +Regulation of lipophagy 0.7462922866905857 1.0668675253664022 0.2860316610829896 1.0 1.0 3 P42858 1 +Response to interleukin 4 0.5408304317861012 1.0654421321246714 0.2866758993343654 1.0 1.0 8 P33993,P49327,Q14145,P11802,P39023 5 +Mesonephros development 0.5850447769255149 1.0652806924326617 0.2867489273268946 1.0 1.0 6 Q12948,Q9BRK4,Q13418 3 +Regulation of potassium ion transmembrane transporter activity 0.5407946988336958 1.0652681606338146 0.2867545966694935 1.0 1.0 8 Q96PU5 1 +Dorsal ventral neural tube patterning 0.6418249204212071 1.0611815850292452 0.2886073865226333 1.0 1.0 4 P17612 1 +Regulation of dendrite morphogenesis 0.5204751768754623 1.0570502730650189 0.2904886441082928 1.0 1.0 13 Q96PU5,Q9H2U1,Q9UQB8,O60828,Q08209 5 +Regulation of peptidyl tyrosine phosphorylation 0.4928131487008885 1.0558266884743914 0.2910474027106322 1.0 1.0 27 O95684,P30153,Q99816,P22681,Q05655,Q15334,P22059,P14174,P42345 9 +Membrane depolarization 0.5171547027016895 1.0552816983564175 0.2912965088289079 1.0 1.0 9 Q96PU5,Q8N335 2 +Vesicle cytoskeletal trafficking 0.5188648573730094 1.0534813417108408 0.2921204412623015 1.0 1.0 16 P42858,P43034,O14617,Q92572,O43795,P62820,P27695 7 +Zinc ion homeostasis 0.6399550938164945 1.0534261952951265 0.2921457036838732 1.0 1.0 4 Q8NEW0,Q15043 2 +Neuronal stem cell population maintenance 0.6104529818271032 1.0514317927319865 0.2930603204007393 1.0 1.0 5 P19022 1 +Cell junction maintenance 0.516298708186873 1.050945620400995 0.2932835660991533 1.0 1.0 9 Q15334,Q9BRK5,Q96J84 3 +Regulation of long chain fatty acid import into cell 0.6393559867571764 1.050942307942889 0.2932850875396533 1.0 1.0 4 P31751 1 +Dna ligation 0.5594493549350217 1.049735739751649 0.2938396270312571 1.0 1.0 7 P18887 1 +Very long chain fatty acid catabolic process 0.6387598198795844 1.0484711031903593 0.2944216091457474 1.0 1.0 4 O14678 1 +Positive regulation of ruffle assembly 0.7413559236848022 1.0483411104441993 0.2944814751986611 1.0 1.0 3 Q7L576 1 +Histone methylation 0.3567042966461397 1.046170122823286 0.2954824944096319 1.0 1.0 54 Q9H7B4,P10412,Q12824,Q9NRG4,P26358,Q86X55,Q6PD62,Q6W2J9,Q9BV86,Q96ST2 10 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.5172748567754616 1.044953804104742 0.2960443207929173 1.0 1.0 16 O95831,O95881 2 +Pyridine nucleotide metabolic process 0.7399902002843772 1.0432215852469318 0.2968456785969486 1.0 1.0 3 P43490 1 +Negative regulation of cell size 0.6374235004022026 1.0429336685495485 0.2969790148789082 1.0 1.0 4 P61586,P42345 2 +Negative regulation of cytokine production involved in inflammatory response 0.7398910118959203 1.0428498761199647 0.2970178272751855 1.0 1.0 3 Q9BWS9 1 +Water homeostasis 0.5146601108151255 1.042647031756348 0.2971117982054287 1.0 1.0 9 Q96PU5 1 +Negative regulation of protein secretion 0.5574885370791596 1.0405643676201386 0.29807777579403 1.0 1.0 7 Q16850 1 +Activation induced cell death of t cells 0.7385116831730316 1.0376823518296918 0.2994179638885454 1.0 1.0 3 P31749 1 +Regulation of dendrite development 0.5105495098636561 1.037385526643113 0.299556220806449 1.0 1.0 20 P98155,P43034,Q9H2U1,Q9UQB8,Q86X55,P61586,Q96PU5,Q7L576,O60828,Q08209 10 +Negative regulation of cell morphogenesis involved in differentiation 0.7369413517847198 1.0318027599519226 0.3021645260915742 1.0 1.0 3 Q9P258 1 +Response to light stimulus 0.3624025089675662 1.0312582621385924 0.3024197254345651 1.0 1.0 57 Q96RU2,P27544,Q9H2U1,Q96K76,Q9BRK5,Q00535,Q9BWF3,Q05655,Q96KB5,P31751,P18074,Q14011,P19447,P52701,P21359,Q9UNS2,Q15555,P31749 18 +Pyridine nucleotide biosynthetic process 0.9612097304405028 1.029781182960287 0.3031127358941836 1.0 1.0 2 P43490 1 +Response to insulin 0.3763853716178813 1.0286718475229877 0.3036339033750193 1.0 1.0 63 Q16836,P11802,Q9UQB8,O14654,Q92572,P31751,P61026,Q7L576,P78527,P49815,Q9BSK2,P43490,P42345 13 +Malonyl coa metabolic process 0.9605522682445752 1.0275637673563287 0.3041550751837114 1.0 1.0 2 O00763 1 +Hormone biosynthetic process 0.511572564822192 1.0270173642116882 0.3044122877265924 1.0 1.0 9 Q14849 1 +Positive regulation of protein acetylation 0.5136632459940804 1.0265809388521905 0.3046178332967484 1.0 1.0 11 Q12824,Q9NPI1,Q969T9 3 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6323182568348344 1.0218029142504783 0.3068741897885676 1.0 1.0 4 Q92890,Q07021 2 +Positive regulation of protein targeting to membrane 0.5534506415032926 1.021691977095875 0.3069267095019565 1.0 1.0 7 Q9UHD1,P31751,Q00535 3 +Negative regulation of helicase activity 0.6322047075060566 1.0213333887138558 0.3070965126357341 1.0 1.0 4 Q96EB6,P33993 2 +Positive regulation of leukocyte proliferation 0.5107256329129798 1.0205624706722507 0.3074617777306208 1.0 1.0 18 Q05397,Q5ZPR3 2 +Positive regulation of organ growth 0.6311120578048237 1.0168163545797406 0.3092408004942015 1.0 1.0 4 O00763 1 +Regulation of neural precursor cell proliferation 0.5122770959735925 1.015271536831617 0.309976408385785 1.0 1.0 15 P48681,P61586,P19022,P55209,P21359 5 +Positive regulation of mitochondrial membrane potential 0.6019384576550182 1.0147070309272916 0.3102455016071748 1.0 1.0 5 P31751 1 +Anaphase promoting complex dependent catabolic process 0.5100729094164312 1.0130690924844414 0.3110271600198477 1.0 1.0 10 Q12834,P30260,P24941,Q9H1A4,Q9UJX2,Q13618,P53350 7 +Dna catabolic process endonucleolytic 0.5297711434187772 1.0116592540227156 0.3117010038987664 1.0 1.0 8 Q9GZR2,O95831 2 +Myeloid cell activation involved in immune response 0.529209108227086 1.008929803444834 0.3130083006700248 1.0 1.0 8 P22681 1 +Negative regulation of hemopoiesis 0.5074045506267213 1.0059348996979025 0.3144468867963992 1.0 1.0 9 P21359 1 +Vesicle transport along microtubule 0.509514713348316 1.0052998438585663 0.3147524902717113 1.0 1.0 11 P42858,P43034,Q92572,P62820,P27695 5 +Camera type eye morphogenesis 0.5281686229837275 1.0038779490835663 0.3154374464291047 1.0 1.0 8 P21359 1 +Positive regulation of defense response to virus by host 0.5712167955934654 1.0030893311625169 0.3158177618205129 1.0 1.0 6 O60828,Q96ST3,Q7Z434 3 +Positive regulation of translation 0.3570219296197722 1.002151432892444 0.3162704603116308 1.0 1.0 56 Q567V2,Q13217,Q06787,P16333,Q07021,Q9H2U1,P61586,P62701,P60228,Q96P11,O60506,Q7Z739,O00571,P78527,Q14011,Q07666,P98179,P42345 18 +Very long chain fatty acid metabolic process 0.5064158965892729 1.000937290296642 0.3168571268130078 1.0 1.0 9 O14678,Q9NZ01 2 +Positive regulation of sodium ion transport 0.5058458037895261 0.9980560846774456 0.3182521634209574 1.0 1.0 9 Q9UHD1,O43865,O43707,Q8N335,P31749 5 +Phosphatidylinositol 3 kinase signaling 0.5089957990681977 0.997880173372168 0.3183374671674417 1.0 1.0 15 Q05397,P22681,P21359,P49815,P31749 5 +Regulation of membrane potential 0.3613119183072237 0.997459123857876 0.3185417053187545 1.0 1.0 58 Q8N0X7,Q14168,P15924,P28331,Q9UQB8,Q96PU5,P31751,P14923,Q9BSK2,O75844,P31749,P42345 12 +Bone development 0.4870083870544758 0.9972507741994072 0.3186428010516957 1.0 1.0 26 A1X283,Q7RTS9,P43034,P61586,Q32P28,Q12948,O75844 7 +Folate transmembrane transport 0.7276314315180149 0.9970264823326388 0.318751655766966 1.0 1.0 3 P41440 1 +Folic acid transport 0.7276314315180149 0.9970264823326388 0.318751655766966 1.0 1.0 3 P41440 1 +Brain morphogenesis 0.5480094993069674 0.9962951051305896 0.319106781396635 1.0 1.0 7 P21359,P19022 2 +Mitochondrial respiratory chain complex assembly 0.4423562380052946 0.994765796333096 0.3198501851845807 1.0 1.0 35 Q9H061,O95831,Q6DKK2,P28331,O75306,Q15526,Q9BSH4,Q9Y512,Q9BSK2,P03886 10 +Heparan sulfate proteoglycan metabolic process 0.5971244131999272 0.9939914774635802 0.3202270166232517 1.0 1.0 5 Q99805,Q7LGA3 2 +Protein autoubiquitination 0.508387986806383 0.9935628819793936 0.320435722433227 1.0 1.0 14 P22681,O95628,O94822,Q5VTB9,P19474,Q96J02 6 +Retrograde axonal transport 0.525944655344859 0.9930850646993729 0.3206685017320367 1.0 1.0 8 Q9NZ32,Q14168,P43034 3 +Glycerol ether metabolic process 0.5688078016993048 0.9922817870013062 0.3210600852946692 1.0 1.0 6 Q8WVX9,P43034,O00116 3 +Muscle tissue development 0.3741576191283553 0.9911598549641883 0.321607529782453 1.0 1.0 44 P60660,P41440,Q9BYT8,P15924,P61586,Q00535,Q15648,Q12948,Q16527,P62942,P21359,Q99873,O75844,Q08209,P42345 15 +Positive regulation of tumor necrosis factor mediated signaling pathway 0.6247037121278277 0.990364888084705 0.3219958009811661 1.0 1.0 4 Q99829 1 +Negative regulation of chromatin binding 0.7257481091746053 0.9900096278230096 0.3221694131500014 1.0 1.0 3 Q7Z5K2,Q08209 2 +Peptidyl proline modification 0.4636943077235906 0.986673770182303 0.3238025927499697 1.0 1.0 31 P62942,Q9Y680,Q9NWM8,Q32P28,Q9BV86,O95302,P26885,Q13526,Q8WUA2 9 +Negative regulation of histone h3 k9 methylation 0.5673816013049513 0.985887754199658 0.3241881967368474 1.0 1.0 6 Q12824 1 +Sterol metabolic process 0.4211604994685411 0.9857031927015854 0.3242787823151418 1.0 1.0 38 Q15392,Q14739,Q06520,Q16850,Q9UBM7,Q14849 6 +Heparan sulfate proteoglycan biosynthetic process 0.6232093055387619 0.98420708214622 0.3250137043287511 1.0 1.0 4 Q99805 1 +Paraxial mesoderm formation 0.9474030243261052 0.9833772992658948 0.3254217785961535 1.0 1.0 2 Q12948 1 +Mesenchyme morphogenesis 0.9474030243261052 0.9833772992658948 0.3254217785961535 1.0 1.0 2 Q12948 1 +Paraxial mesoderm morphogenesis 0.9474030243261052 0.9833772992658948 0.3254217785961535 1.0 1.0 2 Q12948 1 +Long chain fatty acid import across plasma membrane 0.6229528389954804 0.983150717289241 0.3255332659760346 1.0 1.0 4 P31751 1 +Negative regulation of cysteine type endopeptidase activity 0.502433533378125 0.9827975743983324 0.3257070759026943 1.0 1.0 19 Q15392,P78318,Q96K76,Q9NVX2,P31749 5 +Negative regulation of tor signaling 0.5935239811242888 0.9785241087162162 0.3278151734582284 1.0 1.0 5 P49815,Q96B36,O75340 3 +Synaptic transmission glutamatergic 0.5441633459256404 0.9783698113225544 0.3278914534969521 1.0 1.0 7 P21359,P19022 2 +Positive regulation of canonical wnt signaling pathway 0.5012753677000154 0.976420769776562 0.3288559930873931 1.0 1.0 19 Q96K76,Q13418,Q9NVX2,O00571,O75787,O95071,Q13526,P14923 8 +Steroid biosynthetic process 0.4126417021027942 0.9757057576144744 0.3292102982033698 1.0 1.0 39 Q15392,Q16850,Q14739,Q14849 4 +Regulation of mitotic cytokinesis 0.7214731996053839 0.9741065788029706 0.3300036233490178 1.0 1.0 3 Q9Y2S7,Q96Q89 2 +Receptor signaling pathway via stat 0.5045113380378216 0.9732301793984336 0.3304389146732194 1.0 1.0 14 P30153,P40763,Q00535,Q6PD62,P22059,Q9H490 6 +Glycine metabolic process 0.5424333929727978 0.970315251050962 0.3318893775944409 1.0 1.0 7 P34897,P34896,O75600 3 +Positive regulation of gliogenesis 0.500267775225878 0.9698900973523352 0.3321012766048206 1.0 1.0 9 Q9UPY3,P42345 2 +Dna catabolic process 0.5001844098894052 0.9694695169450546 0.3323109822509034 1.0 1.0 9 Q9GZR2,O95831 2 +Protein localization to microtubule 0.5205099987591946 0.9667429106954232 0.3336725700405645 1.0 1.0 8 Q15555 1 +Regulation of epithelial to mesenchymal transition 0.5202614274308653 0.965539249118166 0.334274787046025 1.0 1.0 8 Q12948 1 +Regulation of g0 to g1 transition 0.7180081698347209 0.9612422911025464 0.3364303567193865 1.0 1.0 3 Q15648 1 +G0 to g1 transition 0.7180081698347209 0.9612422911025464 0.3364303567193865 1.0 1.0 3 Q15648 1 +Diencephalon development 0.5404288340894786 0.9609887845859564 0.3365578070388983 1.0 1.0 7 O14949 1 +Establishment of tissue polarity 0.5008434460533996 0.960903690102845 0.3366005952240651 1.0 1.0 11 P43034,O95487,P61586,Q93074 4 +Response to toxic substance 0.3383502542077593 0.960723034221214 0.3366914462878498 1.0 1.0 50 P07099,O95831 2 +Negative regulation of response to cytokine stimulus 0.5610998290082256 0.9577669087924848 0.3381803090694153 1.0 1.0 6 Q7Z739,O94813,Q9Y3Z3 3 +Negative regulation of lipid localization 0.5882416912736219 0.9558754745899646 0.3391351510829294 1.0 1.0 5 P31751,P31749 2 +Bradykinin catabolic process 0.6159679840230747 0.95443089217367 0.3398655752465003 1.0 1.0 4 Q99829,P14735 2 +Odontogenesis 0.5002492526710467 0.954064014744406 0.3400512399463067 1.0 1.0 12 P07942,Q12948,Q6W2J9 3 +Inositol lipid mediated signaling 0.4980976875853362 0.95174148854493 0.3412281027675632 1.0 1.0 18 Q05397,P22681,Q9UBF8,P21359,P49815,P31749 6 +Mitochondrial transmembrane transport 0.3418129862651947 0.9472460546349942 0.3435134124606791 1.0 1.0 47 O95831,O43772,O60830,Q96NB2,Q99595,Q9BSK2 6 +Positive regulation of histone acetylation 0.4955036624473647 0.9458745099167114 0.3442125960619036 1.0 1.0 9 Q12824,Q9NPI1 2 +Positive regulation of peptidyl lysine acetylation 0.4955036624473647 0.9458745099167114 0.3442125960619036 1.0 1.0 9 Q12824,Q9NPI1 2 +Regulation of fatty acid metabolic process 0.4977666421841075 0.945183791418382 0.3445650529514474 1.0 1.0 11 P31751,P31749,O00763 3 +Negative regulation of secretion 0.4989774507011839 0.944916339364428 0.3447015890648526 1.0 1.0 15 P21359,Q16850 2 +Regulation of defense response to virus 0.4988886925148638 0.9444481353968924 0.3449406934968839 1.0 1.0 15 Q96ST3,Q07021,P42224,O60828,Q7Z434,Q96J02,O75844 7 +Fibroblast migration 0.4977559616504458 0.944430687708504 0.3449496058019685 1.0 1.0 17 Q05397,O95429,Q9P258,O94776,P31749 5 +Golgi to plasma membrane protein transport 0.4981791075005373 0.9428968278569884 0.3457336776107858 1.0 1.0 16 Q9HD26,P61026,Q4J6C6 3 +Cellular response to cold 0.9352399737015116 0.9428044674801042 0.3457809262115709 1.0 1.0 2 P17612 1 +Negative regulation of histone modification 0.4963483623875804 0.9422394125253244 0.3460700797534157 1.0 1.0 18 Q12824,P26358,Q96FW1,Q6W2J9,O95071,Q01105 6 +Cardiac chamber development 0.4933176406084711 0.9413832332365836 0.3465085027384496 1.0 1.0 20 O94813,P20248,O96028,Q15036,P15924,Q15648,Q12948,P62942,O75844 9 +Oligodendrocyte differentiation 0.4910406025574355 0.9391218743100824 0.3476681746354626 1.0 1.0 21 O14744,Q96P11,Q93074,P18074,P21359,P42345,P49770 7 +Negative regulation of ion transmembrane transporter activity 0.4965379200439125 0.9389115431181678 0.3477761621754807 1.0 1.0 11 Q9HD26 1 +Early endosome to golgi transport 0.5354448653699152 0.9378334585002488 0.3483300036009216 1.0 1.0 7 O60499 1 +Dna templated transcription initiation 0.421488497793485 0.9374815055699572 0.3485109327143101 1.0 1.0 37 Q12824,Q14241,Q9H2U1,P11802,P50750,O75448,Q93074,Q15648,Q15369,Q9NPJ6,P19447,Q9Y6J9,Q9NVC6,P29083 14 +Skeletal system development 0.3407256963824175 0.9368577007538328 0.34883175993907 1.0 1.0 47 Q15043,O43252,P20248,A1X283,Q7RTS9,P43034,P61586,Q93074,Q32P28,Q92890,Q15648,Q12948,Q9NVX2,O75844 14 +Histone h2b ubiquitination 0.5835210044493042 0.935683142669924 0.3494363524805677 1.0 1.0 5 P50750 1 +Dendritic spine development 0.4902499667488284 0.9346867831852346 0.3499497401781908 1.0 1.0 21 P43034,Q9H2U1,O60678,Q00535,Q9UQB8,P60953,Q15334 7 +Protein localization to condensed chromosome 0.4931774822036132 0.934163870791624 0.3502193692597886 1.0 1.0 9 P50748,Q96DY7 2 +Formation of primary germ layer 0.4968218444492669 0.9335511178065038 0.3505354904424784 1.0 1.0 15 P17612,Q96A65,P07942,Q12948 4 +Positive regulation of pattern recognition receptor signaling pathway 0.4930320056526039 0.9334318634827804 0.3505970351493965 1.0 1.0 9 O00571,P41440 2 +Cellular response to xenobiotic stimulus 0.4763482230537084 0.933230233051288 0.3507011080581235 1.0 1.0 26 Q06520,O15217,P07099 3 +Regulation of focal adhesion disassembly 0.7099049283441831 0.9312555265639012 0.351721401226458 1.0 1.0 3 Q15555 1 +Nucleotide transport 0.4963453799569118 0.930506738687502 0.3521087767381483 1.0 1.0 14 Q9BSK2,O43808,P41440 3 +Canonical wnt signaling pathway 0.4204416172773003 0.929856313475852 0.3524454847530043 1.0 1.0 37 P48729,P25054,Q96K76,Q93074,Q13418,P19022,Q9BRK4,Q9NVX2,O00571,O75787,O95071,Q13526,P14923 13 +Regulation of protein tyrosine kinase activity 0.4942727747124108 0.9273574114152352 0.3537409951140331 1.0 1.0 11 O95684,P22681,Q15334 3 +Neuroepithelial cell differentiation 0.6093345380806912 0.9272531064424456 0.3537951354865236 1.0 1.0 4 P19022,P07437 2 +Regulation of synaptic vesicle exocytosis 0.4916760110094579 0.926610910398409 0.3541285881085709 1.0 1.0 9 Q4J6C6,P35080,Q00535 3 +Cardiac muscle contraction 0.494583185787112 0.9237728643569598 0.3556045861313484 1.0 1.0 16 P17612,P15924,Q96PU5,P14923,P42345 5 +Negative regulation of establishment of protein localization to mitochondrion 0.6082078950064578 0.9226473441888488 0.3561910146428704 1.0 1.0 4 O95429 1 +Cell cell junction organization 0.3905757436692236 0.9209002118607396 0.3571025279858397 1.0 1.0 41 P17612,Q9UDY2,P25054,Q16625,P15924,P55196,P61586,O43815,P19022,P14923,P36404,Q96J84 12 +Dorsal ventral pattern formation 0.5799726288245481 0.9205379447514358 0.3572917136053064 1.0 1.0 5 P17612 1 +Regulation of protein targeting to membrane 0.5091942159683235 0.9120705330441482 0.3617315890254045 1.0 1.0 8 Q9UHD1,P31751,Q00535 3 +Proton transporting v type atpase complex assembly 0.7040050496754828 0.9095150897669764 0.3630782962645491 1.0 1.0 3 Q8N511 1 +Regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.4882316135622907 0.9093028973253956 0.3631902616644922 1.0 1.0 9 Q96QE3,P61978 2 +Regulation of lipid catabolic process 0.4880649564577484 0.9084661368581738 0.3636319970197363 1.0 1.0 9 Q8WTV0,P11802,P31751,O75874,O00763,P31749 6 +Negative regulation of antigen receptor mediated signaling pathway 0.6045545808143846 0.9077340619211444 0.3640187432065715 1.0 1.0 4 Q9NRX4 1 +Negative regulation of t cell receptor signaling pathway 0.6045545808143846 0.9077340619211444 0.3640187432065715 1.0 1.0 4 Q9NRX4 1 +Regulation of dna templated transcription initiation 0.4918398741451463 0.9073325788865216 0.3642309509167176 1.0 1.0 15 P11802,O75448,Q9H2U1,Q93074,Q15648,Q9NPJ6,Q9NVC6 7 +Gdp metabolic process 0.7028424191826088 0.90524072217146 0.3653378726176197 1.0 1.0 3 Q14168 1 +Cd4 positive alpha beta t cell differentiation 0.5492678001059618 0.905015235327024 0.3654573159598957 1.0 1.0 6 Q13951,P42345 2 +Protein localization to cell surface 0.4892237075594213 0.9036347627890554 0.3661891018119232 1.0 1.0 18 Q9HD26,Q92544,Q92643,Q96PU5,Q92538,Q8N335,P31749 7 +Proteoglycan biosynthetic process 0.5759148469230156 0.9032554796788128 0.366390319032047 1.0 1.0 5 Q99805 1 +Oocyte maturation 0.6033782022702148 0.9029391899893898 0.3665581697130808 1.0 1.0 4 P30153 1 +Negative regulation of cell cycle g1 s phase transition 0.4909788641329526 0.9025215924900534 0.3667798565219078 1.0 1.0 14 Q9NPI1,P78527,P24941,Q13642 4 +Regulation of collateral sprouting 0.702095573584582 0.9024967302744225 0.3667930575730791 1.0 1.0 3 Q8N0X7 1 +Negative regulation of intracellular protein transport 0.486646117819642 0.901345043827386 0.3674048913361298 1.0 1.0 9 P21359 1 +Type b pancreatic cell development 0.7015282484517327 0.9004132444821887 0.3679003750677623 1.0 1.0 3 P31749 1 +Enteroendocrine cell differentiation 0.7015282484517327 0.9004132444821887 0.3679003750677623 1.0 1.0 3 P31749 1 +Negative regulation of rig i signaling pathway 0.7010851693521769 0.8987866102513079 0.3687663334774269 1.0 1.0 3 Q92890,Q07021 2 +Calcium mediated signaling 0.4901996186155542 0.898464827391491 0.3689377885946046 1.0 1.0 14 P17612,P42858,Q8IWX8,Q8NE86,O75844,Q08209,P42345 7 +Regulation of systemic arterial blood pressure by hormone 0.700630586582343 0.8971182584762838 0.3696558168328832 1.0 1.0 3 O75787 1 +Postsynaptic specialization organization 0.7002564200807682 0.8957454334433698 0.370388739041023 1.0 1.0 3 P19022 1 +Response to oxygen levels 0.3600555470269492 0.8953855315810215 0.3705810322369265 1.0 1.0 62 P30519,O95831,P22681,O75306,Q13526,P19447,Q15120,P18887,P21359,Q8N511,P55786,P31749,P42345 13 +Formation of translation preinitiation complex 0.4852652903829194 0.8944194582713784 0.3710975052941854 1.0 1.0 9 P55010 1 +Protein targeting to peroxisome 0.6992558270163004 0.8920759928114517 0.3723522017194667 1.0 1.0 3 P40855 1 +Glycoprotein catabolic process 0.5732402817243158 0.891887149491455 0.3724534231766561 1.0 1.0 5 O60502,P33908 2 +Regulation of metal ion transport 0.3288898525254909 0.8915353249058597 0.3726420493044384 1.0 1.0 49 P17612,P42858,Q06787,O76024,Q96PU5,P11171,P61586,Q00535,P46939,Q13642,O43865,O43707,P62942,Q8N335,Q13555,P31749,P27695 17 +Skin development 0.3940025061072754 0.8885437634157897 0.3742483259582521 1.0 1.0 40 Q15392,P15924,Q12948,P21359,O75844 5 +Sarcoplasmic reticulum calcium ion transport 0.5452841222793521 0.8873281022141446 0.3749022799046151 1.0 1.0 6 P17612 1 +Non canonical wnt signaling pathway 0.5451520728585654 0.8867425183242037 0.3752175413485725 1.0 1.0 6 P61586,Q93074 2 +Peptidyl lysine methylation 0.3704487984190476 0.8864704756522002 0.3753640569684067 1.0 1.0 43 Q9H7B4,P10412,Q12824,Q9NRG4,P26358,Q6W2J9,Q96ST2 7 +Organism emergence from protective structure 0.5450380428276438 0.8862368801043621 0.3754898940941071 1.0 1.0 6 Q6W2J9,Q12824,Q6PD62 3 +Protein acetylation 0.3355273001218949 0.886170697386534 0.3755255512352222 1.0 1.0 52 Q12824,Q9NRF9,O75448,O75844,Q9BXJ9,Q86UY6,O00571,Q9NPI1,Q969T9,Q9Y6J9,Q96ST2,Q8IY18,Q01105,Q9Y4A5 14 +Glandular epithelial cell differentiation 0.5992116307270174 0.8859861474886439 0.3756249918906014 1.0 1.0 4 P31749 1 +Glandular epithelial cell development 0.5992116307270174 0.8859861474886439 0.3756249918906014 1.0 1.0 4 P31749 1 +Regulation of neutrophil chemotaxis 0.5443822693535421 0.8833296867066933 0.3770581686236411 1.0 1.0 6 Q07021,Q8NE86 2 +Regulation of neutrophil migration 0.5443822693535421 0.8833296867066933 0.3770581686236411 1.0 1.0 6 Q07021,Q8NE86 2 +Interferon beta production 0.4862704720265937 0.8823321313091909 0.3775972255148132 1.0 1.0 12 Q9BUI4,O14802,Q7Z434,P41440 4 +Positive regulation of interferon beta production 0.4862704720265937 0.8823321313091909 0.3775972255148132 1.0 1.0 12 Q9BUI4,O14802,Q7Z434,P41440 4 +Production of sirna involved in rna interference 0.5982791354157126 0.8821985413522695 0.3776694506176996 1.0 1.0 4 Q9UPY3 1 +L serine catabolic process 0.916502301117689 0.8809492034935978 0.3783453142737589 1.0 1.0 2 P34897 1 +Regulation of anaphase promoting complex dependent catabolic process 0.6961525813876958 0.8807121270953052 0.3784736512923143 1.0 1.0 3 Q12834,P24941 2 +Cerebral cortex neuron differentiation 0.6956337202784091 0.87881458337378 0.3795018177775193 1.0 1.0 3 Q96ST3 1 +Negative regulation of necrotic cell death 0.5970394736842211 0.8771671149660886 0.3803958749693699 1.0 1.0 4 Q13546,Q9NX46,Q92974 3 +Negative regulation of programmed necrotic cell death 0.5970394736842211 0.8771671149660886 0.3803958749693699 1.0 1.0 4 Q13546,Q9NX46,Q92974 3 +Negative regulation of cell substrate adhesion 0.5016804821799681 0.8759293202220384 0.3810684588859943 1.0 1.0 8 P21359,P61586,Q9P258 3 +Adp transport 0.5967277477164581 0.8759026055966315 0.3810829829294246 1.0 1.0 4 O43808 1 +Actin filament based movement 0.4666726805023042 0.8755331873101235 0.3812838608370505 1.0 1.0 26 P15924,Q96PU5,O43795,Q9UM22,Q8N335,P14923 6 +Response to oxygen glucose deprivation 0.9128862590401144 0.8691127182074885 0.3847854809604061 1.0 1.0 2 O95831 1 +Cellular response to oxygen glucose deprivation 0.9128862590401144 0.8691127182074885 0.3847854809604061 1.0 1.0 2 O95831 1 +Vesicle docking involved in exocytosis 0.5001029749544073 0.868360586769233 0.3851969641013326 1.0 1.0 8 Q7Z6M1 1 +Regulation of dna demethylation 0.5928331142887926 0.8601283023976942 0.3897183214416495 1.0 1.0 4 Q93009,Q93008 2 +Regulation of long chain fatty acid import across plasma membrane 0.6904557912894798 0.8599186427923735 0.3898338911344341 1.0 1.0 3 P31751 1 +Positive regulation of fat cell differentiation 0.5183723296226042 0.8589478297151732 0.3903692995437697 1.0 1.0 7 P31749 1 +Dendrite morphogenesis 0.4565127944013672 0.8574535747152475 0.3911942616339727 1.0 1.0 28 P98155,P43034,Q9H2U1,O60678,Q9UQB8,Q96PU5,Q00535,Q15334,O60828,Q08209 10 +Proteoglycan metabolic process 0.517859483739919 0.8565902773744151 0.3916713608757318 1.0 1.0 7 Q99805,Q7LGA3 2 +Layer formation in cerebral cortex 0.5917528113926843 0.8557609246908241 0.3921300330818411 1.0 1.0 4 P43034 1 +Positive regulation of dna templated transcription initiation 0.4814719041180249 0.8547766649839311 0.3926747989337404 1.0 1.0 13 Q9H2U1,O75448,Q93074,Q15648,Q9NPJ6,Q9NVC6 6 +Histone h2a k63 linked ubiquitination 0.6883587942013354 0.8522875672324003 0.3940545048008659 1.0 1.0 3 Q96FW1 1 +Cellular response to peptide hormone stimulus 0.3646732782639861 0.8521782269899855 0.3941151792518012 1.0 1.0 66 Q15043,P16333,Q9UQB8,Q9BSK2,P43490,Q92572,P31751,P61026,P78527,Q05397,P20248,P25054,P11802,O14654,Q7L576,P31749,O43865,P40763,P42224,Q05655,P49815 21 +Cell matrix adhesion 0.4218373327671785 0.8517341287025713 0.3943616738025151 1.0 1.0 35 Q05397,Q7Z460,Q9H2G2,Q9P258,P06756,P51452,P61586,P46939,Q00535,Q13418,Q9Y2S7,Q9Y251,Q9UM22,P21359,P14923 15 +Positive regulation of non motile cilium assembly 0.5907263385388712 0.851614534575217 0.3944280698681026 1.0 1.0 4 Q15555 1 +Golgi to plasma membrane transport 0.4684924040433095 0.8510925205178013 0.3947179599279804 1.0 1.0 24 Q9HD26,Q96A65,P61026,Q15276,Q4J6C6,Q9H4A5 6 +Protein localization to synapse 0.4764830896460253 0.850492235427541 0.3950514754812646 1.0 1.0 9 Q14168,Q15334,Q9UQB8 3 +Alpha beta t cell differentiation 0.4791076685794102 0.8503463983138226 0.3951325276073238 1.0 1.0 11 P40763,P61586,O14617,Q13951,P42345 5 +Positive chemotaxis 0.4960438165254172 0.8489185897567385 0.3959265939450382 1.0 1.0 8 P49815 1 +Regulation of cell substrate adhesion 0.388752473507542 0.8479624980206147 0.3964588564644455 1.0 1.0 40 Q05397,Q7Z460,Q9H2G2,O15144,P20248,Q9P258,Q07021,P51452,P61586,P46939,Q13418,Q9Y2S7,P60953,O43707,P21359,P14923,P36404 17 +Megakaryocyte development 0.6869657566122005 0.8472253301983836 0.396869537356914 1.0 1.0 3 Q15648 1 +Positive regulation of neutrophil migration 0.5892669270335558 0.8457250510686113 0.3977061447975631 1.0 1.0 4 Q07021 1 +Positive regulation of granulocyte chemotaxis 0.5892669270335558 0.8457250510686113 0.3977061447975631 1.0 1.0 4 Q07021 1 +Cell cell signaling by wnt 0.3593189659558851 0.8450966571752853 0.3980568745795361 1.0 1.0 64 O95071,P30153,P48729,Q96K76,P61586,Q93074,Q9GZS3,Q9BRK4,Q9NVX2,Q9NPI1,Q13526,P25054,Q13418,P60953,O00571,O75787,P14923,O43815,Q6PD62,P19022,P49815 21 +Negative regulation of endothelial cell proliferation 0.5351404861463769 0.8424883712724115 0.3995146461171557 1.0 1.0 6 P21359 1 +Protein methylation 0.3588037085671756 0.8403047616922307 0.4007375322854085 1.0 1.0 64 Q9H7B4,O60725,P10412,Q12824,Q9NRG4,P26358,Q86X55,Q6PD62,Q6P2P2,Q6W2J9,Q9BV86,Q96ST2,Q9H993 13 +Microtubule bundle formation 0.4772271945569828 0.8330129582941831 0.4048374210954857 1.0 1.0 13 Q7Z460,O43663,Q9UHD1,Q15555,A0AVF1,Q66K74,P53350 7 +Regulation of skeletal muscle cell differentiation 0.6818912856012584 0.8288343811032295 0.4071981304630758 1.0 1.0 3 Q9BYT8 1 +N terminal protein amino acid acetylation 0.5582735339266581 0.8286488293109442 0.4073031489467416 1.0 1.0 5 Q9BXJ9 1 +Blastocyst growth 0.4915760639498041 0.8275792712214799 0.4079088115276992 1.0 1.0 8 Q14691,Q6PD62 2 +Regulation of postsynapse organization 0.4748606743992387 0.8196424769175665 0.4124199512011768 1.0 1.0 16 P19022,P43034,Q9H2U1,Q9UQB8 4 +Regulation of muscle adaptation 0.4735245360108603 0.8174349766742054 0.4136798942498276 1.0 1.0 12 Q13555,P50750 2 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.5551425983891463 0.8155102438685679 0.4147803033171677 1.0 1.0 5 O00410,P25054 2 +Response to gamma radiation 0.4735777790827879 0.8154321087853091 0.4148250112606781 1.0 1.0 17 P22681,O75844,Q86UE8,P78527 4 +Negative regulation of vasculature development 0.4737196017765814 0.8150804214467773 0.4150262777393994 1.0 1.0 13 P21359,Q12948 2 +Muscle structure development 0.4131156325131815 0.8100657965461101 0.4179023609891485 1.0 1.0 90 Q9H7B4,Q92990,Q13642,Q08209,P60660,P41440,P26358,P15924,P61586,P50750,Q9BWF3,Q12948,Q16527,P21359,Q53EL6,Q53GG5,Q9BYT8,Q00535,O75844,P31749,Q14331,Q13045,Q7Z4V5,P19022,P62942,P42345,Q96PU8 27 +Axis elongation 0.5802519557535404 0.8095024832624119 0.4182261750269882 1.0 1.0 4 Q15648,Q93074 2 +Meiotic spindle organization 0.5531835511015715 0.8073068909158156 0.4194896949054834 1.0 1.0 5 O95067 1 +Peptidyl lysine acetylation 0.3358202334772822 0.8064981269287332 0.4199556875961563 1.0 1.0 46 Q12824,O75844,Q86UY6,Q9NPI1,Q9NRF9,Q9Y6J9,Q96ST2,Q8IY18,Q01105,Q9Y4A5 10 +Negative regulation of defense response to virus 0.5267449759003492 0.8056201501534414 0.4204619034212458 1.0 1.0 6 Q92890,Q07021,Q96J02 3 +Rac protein signal transduction 0.4701493698725663 0.8051999381091685 0.4207043121895391 1.0 1.0 11 Q68EM7,P21359 2 +Response to acid chemical 0.4621138822146773 0.8005929300179769 0.4233673450154227 1.0 1.0 23 Q9UQB8,O95831,P42345 3 +Glial cell apoptotic process 0.5510675939554046 0.7984621944901573 0.424602323632778 1.0 1.0 5 Q05655 1 +Negative regulation of mrna 3 end processing 0.5246230621765469 0.7963410636011371 0.4258338240591011 1.0 1.0 6 P50750 1 +Mesonephric tubule morphogenesis 0.6722359318298884 0.7940687170514963 0.4271554280973237 1.0 1.0 3 Q9BRK4 1 +Extracellular exosome assembly 0.5760471395177615 0.7927062971259997 0.4279489606037658 1.0 1.0 4 Q92783 1 +Kidney morphogenesis 0.5237730736048274 0.7926287796608147 0.4279941359274806 1.0 1.0 6 O75844,Q9BRK4,Q13418 3 +Positive regulation of dendrite development 0.8892176199868582 0.7925538474777799 0.4280378072490802 1.0 1.0 2 P98155 1 +Establishment of planar polarity of embryonic epithelium 0.6718053205497518 0.7925255587948647 0.4280542948870227 1.0 1.0 3 O95487 1 +Negative regulation of transporter activity 0.4685311415987777 0.7921765317656998 0.4282577505121283 1.0 1.0 12 Q9HD26 1 +Negative regulation of inflammatory response 0.4646485151560706 0.7916865306091662 0.4285434780294257 1.0 1.0 9 P25786,Q05655,P28070 3 +Columnar cuboidal epithelial cell development 0.5494062740549733 0.7915296219496651 0.4286349974158367 1.0 1.0 5 P31749 1 +Regulation of cytoplasmic translational initiation 0.6711608023676257 0.7902170474275689 0.4294010218566537 1.0 1.0 3 P16333,P42345 2 +Cd4 positive alpha beta t cell activation 0.5020328282530802 0.7842633731050432 0.4328855863612095 1.0 1.0 7 Q13951,P42345 2 +Regulation of animal organ morphogenesis 0.4631157030440587 0.7841081125487909 0.4329766756044617 1.0 1.0 9 O95487,P61586,Q93074 3 +Positive regulation of lymphocyte differentiation 0.4644794130566736 0.7831560491993985 0.4335354806126545 1.0 1.0 10 Q13951,P12956,P61586,P78527 4 +Positive regulation of glycogen metabolic process 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 1.0 2 P31751 1 +Mammary gland epithelial cell differentiation 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 1.0 2 P31751 1 +Negative regulation of fatty acid transport 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 1.0 2 P31751 1 +Negative regulation of fatty acid beta oxidation 0.8856015779092794 0.781009664741207 0.4347968104040871 1.0 1.0 2 O00763 1 +Negative regulation of cell matrix adhesion 0.5465550257878521 0.7796563858988014 0.4355931569905382 1.0 1.0 5 P21359 1 +Organic acid transmembrane transport 0.4353883604100054 0.7769463374267319 0.4371904311771282 1.0 1.0 30 P23786,P41440,O43772,Q9H2D1,Q96NB2,P31751,O14678,P31749 8 +Cardiac septum development 0.4652411429533299 0.7755930208465129 0.4379893224794473 1.0 1.0 12 Q15036,O94813,P20248,O96028 4 +Protein targeting to mitochondrion 0.364667618613192 0.7748107352230552 0.4384515048629063 1.0 1.0 42 O95376,O95831,O95429,O60830,Q9NS69,P55786 6 +Columnar cuboidal epithelial cell differentiation 0.4803276252401539 0.7741684284667044 0.4388311957958732 1.0 1.0 8 P19022,P07437,P31749,P49327 4 +Dna strand elongation involved in dna replication 0.4655902101301322 0.7714734386284918 0.4404263602892386 1.0 1.0 14 P33993,Q07864,P49005,Q14691,Q9NRF9,P33991,P40938 7 +Regulation of glial cell apoptotic process 0.6656755798432432 0.7706305054425818 0.4409259742695659 1.0 1.0 3 Q05655 1 +Apoptotic dna fragmentation 0.5174549842743021 0.7651231775335413 0.4441981995241135 1.0 1.0 6 O95831 1 +Cellular response to oxygen levels 0.3974274937141242 0.7646155198502846 0.4445005247821556 1.0 1.0 37 O95831,P22681,O75306,Q15120,Q8N511,P55786,P31749,P42345 8 +S adenosylmethionine metabolic process 0.5427920242823945 0.7640362772852255 0.4448456243333867 1.0 1.0 5 Q9NZL9,O43865,P23526 3 +Regulation of small gtpase mediated signal transduction 0.370258082047929 0.76078682639702 0.4467844041225592 1.0 1.0 41 P41440,P22681,Q15555,P21359,Q92888,P49815,Q68EM7 7 +Ras protein signal transduction 0.3636770657861293 0.7602866360627425 0.4470832683190056 1.0 1.0 70 Q15392,P57105,Q96RU2,P41440,P26358,P22681,Q15555,P21359,Q92538,Q92888,Q68EM7 11 +Regulation of striated muscle cell differentiation 0.4771192513887046 0.759026854772622 0.4478364924540186 1.0 1.0 8 Q9BYT8 1 +Vascular associated smooth muscle cell apoptotic process 0.6621523600848968 0.7581085967982861 0.448385973623103 1.0 1.0 3 P26358 1 +Vascular associated smooth muscle cell differentiation 0.6621523600848968 0.7581085967982861 0.448385973623103 1.0 1.0 3 P26358 1 +Regulation of vascular associated smooth muscle cell differentiation 0.6621523600848968 0.7581085967982861 0.448385973623103 1.0 1.0 3 P26358 1 +Cardiac septum morphogenesis 0.5155622625454241 0.756914991773009 0.4491007930796207 1.0 1.0 6 O94813,P20248 2 +Response to ether 0.6606379480433916 0.7527408360175322 0.4516056656642213 1.0 1.0 3 Q14103,P11802 2 +Endothelial cell proliferation 0.4616206868747489 0.7525724217875219 0.4517068950659744 1.0 1.0 17 Q8WTV0,P57105,P40763,P21359,Q9H2J4,P31749 6 +2 oxoglutarate metabolic process 0.4757352711469947 0.7525092202406256 0.4517448871787899 1.0 1.0 8 P48735 1 +Negative regulation of signaling receptor activity 0.5655523541667209 0.7510885538174614 0.4525993638320806 1.0 1.0 4 P22681 1 +Dna methylation 0.4612984857936228 0.7508892967737211 0.4527192823064916 1.0 1.0 17 Q8NB78,O75844 2 +Striated muscle adaptation 0.5654602248037084 0.7507252493341675 0.4528180241218398 1.0 1.0 4 Q13555 1 +Regulation of cytoplasmic translation 0.4603694090532599 0.7438267695203732 0.4569812828890656 1.0 1.0 15 O60506,P16333,Q9H2U1,P42345 4 +Cell surface receptor signaling pathway involved in cell cell signaling 0.3727689595361381 0.7421313563910469 0.4580077532621156 1.0 1.0 75 Q9UQB8,O95071,Q08209,P30153,P48729,Q96K76,P61586,Q93074,Q9GZS3,Q9BRK4,Q9NVX2,Q9NPI1,Q13526,P25054,Q00535,Q13418,Q15334,O00571,O75787,Q14168,P31749,P14923,O43815,Q6PD62,P19022,P49815 26 +Tight junction organization 0.4592484827127208 0.7401947361151558 0.4591818411427515 1.0 1.0 17 P17612,P25054,Q16625,O43815,P36404 5 +Cytokine mediated signaling pathway 0.3196875823158413 0.739605529447423 0.4595393855386214 1.0 1.0 47 Q14166,P22681,P67870,P17612,P43034,Q12948,Q99829,Q13418,Q7Z739,Q15648,Q9Y3Z3,Q7Z434,P31749,O94813,P40763,P42224,Q6PD62,Q13546,O43707 19 +Insulin receptor signaling pathway 0.4203902017019433 0.7383075218863463 0.4603275966521116 1.0 1.0 32 P11802,Q9UQB8,O14654,Q92572,P31751,P49815,P43490 7 +Observational learning 0.8717948717948837 0.7373451646104565 0.4609124730526366 1.0 1.0 2 P21359 1 +Calmodulin dependent kinase signaling pathway 0.8717948717948711 0.7373451646104163 0.460912473052661 1.0 1.0 2 O75844 1 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.5620028717870506 0.7371186095751734 0.4610502231445796 1.0 1.0 4 O75787 1 +Tetrapyrrole catabolic process 0.5613706171287045 0.7346361437599308 0.4625611195481363 1.0 1.0 4 P30519 1 +Cellular response to vascular endothelial growth factor stimulus 0.5096656012744045 0.7314432667350712 0.4645084457344046 1.0 1.0 6 Q12948 1 +Regulation of muscle cell differentiation 0.4554507946512049 0.7281396804285805 0.4665280857294842 1.0 1.0 19 P26358,Q9BYT8,P50750,Q9BWF3,P42345 5 +Protein dna complex assembly 0.3189226031590099 0.7280188029069868 0.4666020762342295 1.0 1.0 52 Q9H7B4,Q9Y6J9,Q12824,Q99733,Q92674,P55209,Q9NRF9,P50748,P10412 9 +Prenylation 0.868507560815263 0.727050566921206 0.4671949794144994 1.0 1.0 2 P49356 1 +Regulation of hormone levels 0.3327178182175547 0.7268507623461175 0.4673173825242798 1.0 1.0 58 Q15043,Q96ST3,Q16836,O60678,Q06520,Q15648,Q9HB40,P22059,Q8NE86,Q13555,O75787,Q8TC12,P62820,O75844,Q08209,Q9UBM7,Q14849 17 +Peptidyl lysine dimethylation 0.4512702472930016 0.7258890069308503 0.467906816195569 1.0 1.0 9 Q9NRG4 1 +Negative regulation of peptidyl serine phosphorylation 0.5081483201742419 0.7249147797474293 0.4685043131577031 1.0 1.0 6 Q8N335 1 +Alcohol biosynthetic process 0.4134674755652872 0.7244962143440914 0.4687611504481417 1.0 1.0 33 Q15392,Q16850,Q14739 3 +Negative regulation of neuron projection development 0.4555434991375241 0.7240139876972304 0.469057147691797 1.0 1.0 18 Q8N0X7,Q96G23,P43034,P61586,Q86X55,Q00535,Q15375,Q02790 8 +Viral transcription 0.4558390896043894 0.7219182186073582 0.4703447594601915 1.0 1.0 14 Q4G0J3,Q12824,P50750,O14646,P19474 5 +Regulation of canonical wnt signaling pathway 0.4021766016016062 0.7180133070779838 0.4727490818633528 1.0 1.0 35 P48729,P25054,Q96K76,Q13418,P19022,Q9NVX2,Q9BRK4,O00571,O75787,O95071,Q13526,P14923 12 +Negative regulation of type i interferon mediated signaling pathway 0.5570816797115877 0.7178452136578118 0.4728527316035815 1.0 1.0 4 Q7Z739,Q9Y3Z3 2 +Regulation of glucose metabolic process 0.4471861650041565 0.7172184631472581 0.4732393086613782 1.0 1.0 23 Q9BYT8,P31751,O00763,Q15120,O75844,P31749 6 +Multicellular organismal movement 0.4868237505345677 0.7156954760629438 0.4741794048309691 1.0 1.0 7 P18887 1 +Cellular response to leptin stimulus 0.5561697266978594 0.7142862383677142 0.4750502000503682 1.0 1.0 4 P40763,P20248 2 +Regulation of phospholipid catabolic process 0.5556633606852311 0.7123118443802634 0.4762716911384748 1.0 1.0 4 Q8WTV0,O75874 2 +Regulation of nucleobase containing compound transport 0.4496842219726777 0.7101155593079449 0.4776324784159562 1.0 1.0 10 Q9ULX6,Q96ST2,Q07666 3 +Positive regulation of neural precursor cell proliferation 0.485528712906364 0.7099071090959745 0.4777617416398041 1.0 1.0 7 P55209 1 +Organic hydroxy compound biosynthetic process 0.3249855327014284 0.7098648729210643 0.4777879352806735 1.0 1.0 46 Q15392,Q16850,Q14739 3 +Skin epidermis development 0.4529950901837424 0.7062162454447072 0.480053669164608 1.0 1.0 15 P21359,P18074,O75844 3 +Snrna transport 0.6461690233475867 0.7019290728044532 0.4827233970828755 1.0 1.0 3 P62826,Q09161 2 +Negative regulation of protein localization to cell periphery 0.4458514964780838 0.699485357286544 0.4842487607538923 1.0 1.0 9 Q9HD26,Q9NQ48 2 +Striated muscle contraction 0.4507771785707757 0.6991063030565001 0.4844855997567077 1.0 1.0 18 P17612,P15924,Q96PU5,P14923,P42345 5 +Regulation of calcium ion transmembrane transporter activity 0.4510019820386314 0.6975379991494397 0.4854661674490974 1.0 1.0 14 P17612,P42858,Q00535,P62942,P27695 5 +Smooth muscle cell apoptotic process 0.501495460919809 0.6964216171467034 0.4861648290980462 1.0 1.0 6 Q53EL6,P26358,Q96EB6 3 +Peptidyl arginine modification 0.4633474149655027 0.6945808832820718 0.4873179959148936 1.0 1.0 8 O14744,O60678,Q86X55,Q6P2P2,Q99873 5 +Bone mineralization 0.4458463793077141 0.6913540714001104 0.4893430594508863 1.0 1.0 10 P18074,O75844,Q6W2J9 3 +Inner cell mass cell differentiation 0.8570019723865854 0.6913498284742177 0.4893457251810116 1.0 1.0 2 Q6PD62 1 +Regulation of wnt signaling pathway 0.3306840170388801 0.6879012141184578 0.4915149919631265 1.0 1.0 45 P30153,P48729,P25054,Q96K76,Q13418,P19022,Q9BRK4,Q9NVX2,O00571,O75787,O95071,Q13526,P49815,P14923 14 +Gamma aminobutyric acid secretion 0.8556870479947538 0.6873037418530409 0.4918913413456056 1.0 1.0 2 P21359 1 +Gamma aminobutyric acid transport 0.8556870479947538 0.6873037418530409 0.4918913413456056 1.0 1.0 2 P21359 1 +Acid secretion 0.8556870479947538 0.6873037418530409 0.4918913413456056 1.0 1.0 2 P21359 1 +Muscle adaptation 0.4481825049556187 0.6862776356707845 0.4925380490429942 1.0 1.0 13 P50750 1 +Positive regulation of wnt signaling pathway 0.4433623198188436 0.6857115518415424 0.4928950207492284 1.0 1.0 22 Q96K76,Q13418,Q9NVX2,O00571,O75787,O95071,Q13526,P14923 8 +Vitamin transmembrane transport 0.4797721714413097 0.6842834342914706 0.493796205490624 1.0 1.0 7 Q9H2D1,P41440 2 +Trna 5 end processing 0.4978759352453743 0.6810152774586132 0.4958618235923391 1.0 1.0 6 Q99575 1 +Morphogenesis of an endothelium 0.6391150194711797 0.6774907112560238 0.498094661585426 1.0 1.0 3 P61586 1 +T cell apoptotic process 0.442837529394871 0.6767052055245303 0.4985930130424432 1.0 1.0 10 P24390,P62753,P31749 3 +Neuron apoptotic process 0.3107957490054897 0.6742623165305475 0.5001445572676269 1.0 1.0 51 P78362,O95831,O43813,Q99720,P31751,P21359,Q01105 7 +Peptidyl tyrosine modification 0.3783136900702072 0.6729094260917158 0.5010049150176075 1.0 1.0 38 Q05397,O95684,P30153,Q99816,P22681,Q05655,Q96KB5,Q15334,P22059,P14174,P42345 11 +Regulation of receptor signaling pathway via stat 0.4770360400236423 0.6721678747325658 0.5014768300435963 1.0 1.0 7 Q9H490,P30153 2 +Positive regulation of posttranscriptional gene silencing 0.4459003249665932 0.6703575895960852 0.5026298633312904 1.0 1.0 15 Q01085,Q06787,P40763,P17844,P51114,Q13546,Q9HAV4,Q02750 8 +Lipopolysaccharide mediated signaling pathway 0.4396460622067085 0.6694498949894526 0.5032085325994344 1.0 1.0 9 P31749,Q86UE4,P14174 3 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.4432218007858416 0.6660436068129115 0.5053832282086432 1.0 1.0 12 Q96QE3,P61978,Q96RU2 3 +Protein modification by small protein removal 0.327802997421429 0.6635785360084345 0.5069600986614593 1.0 1.0 45 Q96RU2,Q9UPU5,P34897,Q93008,Q96K76,Q99627,Q9UNS2,Q6GQQ9,Q93009,Q96FW1,Q7L5N1,Q99496,Q9BT78,P19474,Q9Y6J9,Q96J02,Q9Y4A5 17 +Actin filament network formation 0.5430143259561402 0.6634171370324153 0.5070634333753199 1.0 1.0 4 O15511 1 +Biomineralization 0.4441442543745765 0.6632313102892179 0.5071824215225598 1.0 1.0 14 P18074,O75844,Q6W2J9,Q9Y4P1 4 +Regulation of calcium mediated signaling 0.4932592379977579 0.6614687613155674 0.5083117416917855 1.0 1.0 6 Q8IWX8,P42345,P42858 3 +Positive regulation of plasma membrane bounded cell projection assembly 0.4323803295930434 0.6606488142643577 0.508837556480281 1.0 1.0 25 O15144,P42858,Q16625,Q06787,P25054,Q8NCA5,P60953,Q7L576,P42345,Q15555,P27695 11 +One carbon metabolic process 0.4407686730929259 0.6597132292871541 0.5094378754401483 1.0 1.0 11 P34897,O43865,P34896 3 +Positive regulation of chemokine c c motif ligand 5 production 0.8464825772518124 0.659186649895199 0.5097759186210791 1.0 1.0 2 Q7Z434 1 +Chemokine c c motif ligand 5 production 0.8464825772518124 0.659186649895199 0.5097759186210791 1.0 1.0 2 Q7Z434 1 +Detection of stimulus 0.4431263873974345 0.6581668453659221 0.5104309265519995 1.0 1.0 14 Q05397,P19022,Q15555,P14923 4 +Reactive oxygen species biosynthetic process 0.4387897234690729 0.6570863146545465 0.5111254180076372 1.0 1.0 10 Q9BSK2,Q15067 2 +Polyamine biosynthetic process 0.6320289378493775 0.6531814766480393 0.5136392904574305 1.0 1.0 3 Q96QD8,P52788 2 +Positive regulation of cellular amide metabolic process 0.335805257554401 0.6521095207216469 0.5143305226378592 1.0 1.0 63 P16333,P60228,O60506,P98179,Q567V2,Q06787,Q07021,Q9H2U1,P61586,P78527,P20248,Q13217,P62701,Q7Z739,O00571,Q07666,Q96P11,Q05655,Q14011,P42345 20 +Negative regulation of t cell proliferation 0.5149521916412132 0.650527078823678 0.5153518161596575 1.0 1.0 5 Q92990 1 +Positive regulation of phosphatidylinositol 3 kinase signaling 0.5144793248856092 0.6486346974578105 0.5165745227447922 1.0 1.0 5 Q05397 1 +Transmission of nerve impulse 0.4716846994949986 0.6485983983118111 0.5165979910582792 1.0 1.0 7 Q06787,P43034,P42345,Q7Z406 4 +Positive regulation of carbohydrate metabolic process 0.4716624681910688 0.6485008438642712 0.5166610652071215 1.0 1.0 7 P31751,P31749 2 +Cholesterol catabolic process 0.8425378040762629 0.6472502437100555 0.5174699982010829 1.0 1.0 2 Q15036 1 +Vacuolar proton transporting v type atpase complex assembly 0.8422090729783004 0.6462587185057336 0.5181118178298516 1.0 1.0 2 Q8N511 1 +Outer mitochondrial membrane organization 0.5138563352931387 0.6461435611516698 0.5181863864800145 1.0 1.0 5 Q9Y512,Q9NS69 2 +T cell activation involved in immune response 0.4347685181271929 0.6460065717841217 0.5182750993935019 1.0 1.0 9 P62753,P42345 2 +Positive regulation of neurotrophin trk receptor signaling pathway 0.841880341880338 0.6452676867912633 0.51875372911105 1.0 1.0 2 Q7L576 1 +Regulation of neurotrophin trk receptor signaling pathway 0.841880341880338 0.6452676867912633 0.51875372911105 1.0 1.0 2 Q7L576 1 +Vesicle tethering to golgi 0.6295092914674619 0.64459862176222 0.5191873282691517 1.0 1.0 3 Q658Y4 1 +Nadp metabolic process 0.4404771652508952 0.6431870253016886 0.5201027512192649 1.0 1.0 15 O75874,Q4G0N4,P48735 3 +Response to arsenite ion 0.6289743521797069 0.6427806555613369 0.5203664369471861 1.0 1.0 3 Q9H2U1 1 +Glutathione metabolic process 0.4388077885291363 0.6409374021845057 0.5215633540948481 1.0 1.0 19 O15217,O75874,P21266 3 +Regulation of cell matrix adhesion 0.4332346185762078 0.6408683678685366 0.5216082090518799 1.0 1.0 23 Q05397,Q7Z460,Q9H2G2,Q9P258,P51452,P61586,P46939,Q9Y2S7,P21359,P14923 10 +Response to hydroperoxide 0.8389217619987005 0.6363707854121746 0.5245347778756737 1.0 1.0 2 P18887 1 +Positive regulation of lipid catabolic process 0.8389217619987006 0.6363707854121743 0.5245347778756739 1.0 1.0 2 P31751 1 +Synaptic vesicle cytoskeletal transport 0.5348502811155831 0.6323286937139301 0.5271721176544217 1.0 1.0 4 Q92572 1 +Regulation of smooth muscle contraction 0.5347277865121293 0.631865253824253 0.5274749296204151 1.0 1.0 4 Q14247,P61586 2 +Alpha beta t cell activation 0.4377321604856687 0.6295196541428218 0.5290089057170348 1.0 1.0 15 P35268,P40763,P61586,O14617,Q13951,Q96J02,P42345 7 +Protein maturation by protein folding 0.5095723890053455 0.6290771029743647 0.5292985798206686 1.0 1.0 5 P62942,O76024 2 +Oocyte differentiation 0.4490394426137199 0.6287381573840487 0.5295204929142268 1.0 1.0 8 P30153,Q9H6S0,Q9Y2W6,Q9BQA1,Q15645 5 +Regulation of cilium assembly 0.4375013628190564 0.6283732379207088 0.5297594643889834 1.0 1.0 15 Q15555,Q4KMP7 2 +Dna dependent dna replication 0.3552543811510372 0.6281496775664657 0.5299058923883004 1.0 1.0 73 P33993,P49005,P24941,Q9Y248,Q9BY42,Q9Y2S7,Q7Z7L1,Q07864,P78362,P41440,Q14181,P40937,P50750,Q92547,Q9UFC0,P23921,P35251,P27694,Q14691,O43913,Q9Y3Z3,Q86V81,O75844,Q96QE3,Q9BRT9,Q9UBD5,Q9NRF9,P33991,P40938 29 +Oligodendrocyte development 0.432525833383987 0.626940261051071 0.5306983948165329 1.0 1.0 10 Q13144,Q9NR50,Q9UI10,Q96P11,Q93074,P18074,P49770 7 +Mitotic spindle midzone assembly 0.5333480665405703 0.6266516539371848 0.5308876011923287 1.0 1.0 4 Q02241 1 +Lipophagy 0.5089323257626821 0.6265369529322575 0.5309628069070667 1.0 1.0 5 P42858 1 +Myeloid leukocyte mediated immunity 0.435428879611938 0.6234224951801486 0.5330069192518576 1.0 1.0 13 P22681,Q7Z434 2 +Regulation of myeloid leukocyte mediated immunity 0.4478564204556344 0.6233525420643731 0.5330528772497953 1.0 1.0 8 Q9H2U1,Q92499,Q7Z434 3 +Cilium organization 0.337846246572213 0.6212765425572423 0.5344176849918849 1.0 1.0 43 Q96A65,Q15555,A0AVF1,A6NIH7 4 +Dna catabolic process exonucleolytic 0.8333333333333388 0.6196776045390785 0.5354700629785214 1.0 1.0 2 Q9GZR2 1 +Regulation of muscle system process 0.4195507593649588 0.619370981360178 0.5356719933684202 1.0 1.0 27 P17612,P14923,P15924,P50750 4 +Positive regulation of neurogenesis 0.3644789154052749 0.6187650910590334 0.5360711224868637 1.0 1.0 39 O14744,O94813,P43034,Q9H2U1,Q9UQB8,P55209,Q7L576,Q9UPY3,P42345 9 +Primary alcohol metabolic process 0.4355458337981962 0.6186217963082468 0.5361655395264944 1.0 1.0 17 Q06520 1 +Ether biosynthetic process 0.5062862767293662 0.6160635030625183 0.5378526087568598 1.0 1.0 5 Q8WVX9,O00116 2 +Positive regulation of sister chromatid cohesion 0.4821798677653006 0.6150774143064658 0.5385035969426275 1.0 1.0 6 Q8IY18,Q96MF7 2 +Endocrine system development 0.4279333429341606 0.6134219129273663 0.5395974005420392 1.0 1.0 9 P21359,P31749 2 +Zinc ion transport 0.8310322156476155 0.6128475457124967 0.5399771495311765 1.0 1.0 2 Q8NEW0 1 +Roof of mouth development 0.5051408858677828 0.6115439057989945 0.540839560883895 1.0 1.0 5 Q6W2J9 1 +Positive regulation of membrane potential 0.4631728354098402 0.6114792488031513 0.5408823520530461 1.0 1.0 7 P31751 1 +Regulation of attachment of spindle microtubules to kinetochore 0.4812607143290399 0.611263846317368 0.5410249215197447 1.0 1.0 6 Q9P258,P25054 2 +Deoxyribonucleotide biosynthetic process 0.4810622930616062 0.6104413367444705 0.5415694925077739 1.0 1.0 6 P34896,P23921 2 +Morphogenesis of a polarized epithelium 0.4334873748711303 0.6085049046506037 0.542852654014311 1.0 1.0 15 P43034,O95487,P61586,Q93074,P61026 5 +External encapsulating structure organization 0.4073498092445035 0.6069759443606544 0.5438668765349859 1.0 1.0 30 P39210,P21359,Q12948,P41440 4 +Cardiac muscle cell cardiac muscle cell adhesion 0.503835185266365 0.606402271038929 0.5442476607730344 1.0 1.0 5 P15924 1 +Respiratory chain complex iii assembly 0.6181235357289793 0.6062378736489854 0.5443568064240201 1.0 1.0 3 Q9BSK2 1 +Response to platelet derived growth factor 0.4262565556751785 0.6054793344889453 0.5448605516991596 1.0 1.0 9 P22681 1 +Retinoic acid metabolic process 0.8280736357659395 0.6041042843769745 0.5457743112702416 1.0 1.0 2 Q9HB40 1 +Protein homotetramerization 0.4327260113727639 0.6039370020387996 0.5458855269314982 1.0 1.0 16 Q13085,P34897,O00763,P34896 4 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 1.0 3 P10321,P04439 2 +Regulation of tolerance induction 0.6172311739559233 0.603261870353925 0.5463344943210944 1.0 1.0 3 Q96J02,P09429 2 +Detection of external biotic stimulus 0.6172311739559216 0.6032618703539186 0.5463344943210986 1.0 1.0 3 Q8WTV0,P04439 2 +Glial cell differentiation 0.3353610227308569 0.6019313931940177 0.5472198063640656 1.0 1.0 43 O14744,Q96P11,P61586,Q00535,Q93074,Q13418,P18074,P31751,P19022,Q9UPY3,P21359,P31749,P42345,P49770 14 +Response to growth hormone 0.4609345624663243 0.6017993951133861 0.5473076778229706 1.0 1.0 7 Q05397,P31749 2 +Regulation of histone phosphorylation 0.4786519257340029 0.6004710000125845 0.5481923822769916 1.0 1.0 6 Q9ULX6,P50750 2 +Intraciliary transport involved in cilium assembly 0.8267587113741106 0.6002323916927693 0.5483513690396189 1.0 1.0 2 A0AVF1 1 +Negative regulation of cell population proliferation 0.385724578900133 0.596488007178157 0.5508492632550219 1.0 1.0 89 Q92990,Q15392,O43324,Q9NRG4,P52756,Q96J02,O14737,P61586,Q32P28,Q9BRK4,Q9UPY3,Q9NPI1,Q92879,P21359,Q9NNW5,Q53EL6,P57105,Q12824,Q96DY7,P25054,Q13418,Q15648,Q96G23,P40763,P42224,O43815,Q99627,P49815,Q99816 29 +Negative regulation of atp metabolic process 0.441874219794502 0.5962698842106522 0.5509949463525188 1.0 1.0 8 O75746,P40763,P61586 3 +Folic acid containing compound catabolic process 0.8247863247863371 0.5944409186318202 0.5522172472694187 1.0 1.0 2 Q9NRN7 1 +Positive regulation of intracellular protein transport 0.3015956872109833 0.5908528420086437 0.5546190256054828 1.0 1.0 51 P62826,Q9UHD1,Q92688,Q96Q89,Q15154,O95071,P55786,P17612,Q9Y282,O00410,O14737,Q13148,Q9BZL1,P31751,Q9NR31,Q00535,P60953,Q7Z434,Q12955,P14923,O95376,Q92544,Q05655,Q99496 24 +Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.4759592965807199 0.589380578627544 0.5556060018129703 1.0 1.0 6 P21359,P30154 2 +Regulation of chromatin assembly or disassembly 0.4283078645738273 0.5888637474520574 0.5559526784463988 1.0 1.0 13 P26358,Q96ST3,Q86UE8,Q6PD62 4 +Skeletal muscle organ development 0.4273955557327563 0.5869294120868539 0.5572511153225597 1.0 1.0 20 P60660,P41440,Q9BYT8,P17844,P61586,Q00535,P51114,P21359,Q08209 9 +Rna guanine n7 methylation 0.6118568914367271 0.5854372268328698 0.5582537636265319 1.0 1.0 3 P57081 1 +Negative regulation of microtubule polymerization 0.4984427555097719 0.5852899518350497 0.5583527700719757 1.0 1.0 5 P04350,Q02790 2 +Negative regulation of protein localization to membrane 0.4235960324284172 0.5844581986625531 0.5589120809861214 1.0 1.0 10 Q9HD26,Q9NQ48 2 +Ribosomal large subunit export from nucleus 0.4563398785744409 0.5820413814739333 0.5605388076127813 1.0 1.0 7 O14980,Q9NVU7,Q96D46 3 +Regulation of cellular ketone metabolic process 0.4267565363538367 0.5813914820689036 0.5609766369623652 1.0 1.0 13 P31751,P31749,O00763,Q15120 4 +Positive regulation of myeloid leukocyte cytokine production involved in immune response 0.4383404737476705 0.58039600547861 0.5616475982601676 1.0 1.0 8 Q9H2U1,Q92499,P14174,Q7Z434 4 +Regulation of cell morphogenesis involved in differentiation 0.4122992127550974 0.5786450450517313 0.562828703915319 1.0 1.0 27 Q05397,Q9P258,Q07021,Q9H2U1,Q9UQB8,P43034,Q13418,P78527 8 +Anterograde axonal transport 0.4268548833554758 0.578298540098939 0.5630625798892539 1.0 1.0 14 Q14168,Q92572,Q9NVJ2 3 +Lipid droplet organization 0.4203690619980137 0.5777620702170941 0.5634247664878682 1.0 1.0 9 Q8N0X7 1 +Cellular response to gamma radiation 0.421985299454192 0.5768623747335387 0.564032429382282 1.0 1.0 10 O75844,Q86UE8 2 +Regulation of transporter activity 0.3320632376257607 0.5765034016803628 0.5642749712611612 1.0 1.0 43 P17612,Q9HD26,P42858,P07384,Q06787,Q96PU5,O43865,Q05655,P46939,Q00535,Q13642,Q15334,Q13546,Q9BSH4,O43707,P62942,Q8N335,P27695 18 +Serine family amino acid metabolic process 0.4254905126194849 0.5753090962916411 0.5650822706864618 1.0 1.0 13 P78330,P34897,P34896,O75600 4 +Positive regulation of response to wounding 0.4254628664452848 0.5751764341898041 0.565171978855461 1.0 1.0 13 Q05397,Q16625,P42345 3 +Regulation of phosphatidylinositol 3 kinase signaling 0.4229983355451917 0.5743559177111767 0.5657269768742728 1.0 1.0 11 Q05397,P49815 2 +Regulation of systemic arterial blood pressure by renin angiotensin 0.8175542406311618 0.5733772092333448 0.5663893182040725 1.0 1.0 2 O75787 1 +Neuromuscular synaptic transmission 0.8168967784352372 0.571475974509475 0.5676770417602262 1.0 1.0 2 O60333 1 +Retinal ganglion cell axon guidance 0.4948270664846818 0.57124811066996 0.5678314700136728 1.0 1.0 5 O94813,P83731 2 +Cellular response to reactive oxygen species 0.388936239245653 0.5700892361186305 0.5686171753570866 1.0 1.0 33 O95831 1 +Negative regulation of histone methylation 0.4216889345708074 0.5681658697152242 0.5699223442382404 1.0 1.0 11 P26358,Q12824 2 +Mammalian oogenesis stage 0.8155818540433875 0.5676804553613103 0.5702519651182576 1.0 1.0 2 P62753 1 +Heterotypic cell cell adhesion 0.4211700775733437 0.5657171589708709 0.5715860687930507 1.0 1.0 11 P15924,P41440 2 +Schwann cell proliferation 0.8145956607495233 0.5648399331904755 0.572182642687393 1.0 1.0 2 Q96G23 1 +Negative regulation of schwann cell proliferation 0.8145956607495233 0.5648399331904755 0.572182642687393 1.0 1.0 2 Q96G23 1 +Negative regulation of glial cell proliferation 0.8145956607495233 0.5648399331904755 0.572182642687393 1.0 1.0 2 Q96G23 1 +Positive regulation of myelination 0.8145956607495052 0.5648399331904234 0.5721826426874286 1.0 1.0 2 O75746 1 +Gastrulation 0.4094898006786679 0.5630479289248007 0.5734022474880338 1.0 1.0 27 P17612,Q96A65,P62753,P07942,P06756,Q6PD62,Q12948,Q99496,Q9NPQ8 9 +Limbic system development 0.4201381017607239 0.5623882648747026 0.5738515127499615 1.0 1.0 22 O14949,P43034,Q00535,O15511,P18887,P21359,Q9H0D6 7 +Cardiac conduction 0.4239318306695405 0.5617750893302704 0.574269266437716 1.0 1.0 15 P17612,P15924,O75844 3 +Sphingolipid biosynthetic process 0.4239488623563229 0.5608296945025669 0.574913641583874 1.0 1.0 17 P20248,Q96G23,O15270,Q06136,Q05655,P22059,Q99805 7 +Sensory organ development 0.3207764944527491 0.5605242903107385 0.5751218762024985 1.0 1.0 61 P48681,P33993,Q9Y4P1,P20248,A1X283,O95487,P43034,P40763,Q15648,Q15293,Q12948,P39210,P21359,Q15555,Q9H0D6 15 +Response to leucine 0.8122945430637789 0.558232624126383 0.5766855460301934 1.0 1.0 2 P42345 1 +Cellular response to leucine 0.8122945430637789 0.558232624126383 0.5766855460301934 1.0 1.0 2 P42345 1 +Aspartate family amino acid metabolic process 0.421671950286469 0.5577566208852106 0.5770105879977301 1.0 1.0 20 Q13126,P52788,Q9NRN7,O75600 4 +Dna geometric change 0.2978107177663947 0.5573771734995199 0.5772697579847335 1.0 1.0 51 P33993,Q9BRT9,Q9Y248,Q12873,Q9H2U1,P18074,P12956,P22626,Q14691,P19447,O00571,O14646,Q9H4L7 13 +Regulation of calcium ion transport into cytosol 0.4176736232371894 0.5566373928932091 0.5777752002097296 1.0 1.0 10 P17612,P62942,P42858 3 +Regulation of release of sequestered calcium ion into cytosol 0.4176736232371894 0.5566373928932091 0.5777752002097296 1.0 1.0 10 P17612,P62942,P42858 3 +Regulation of protein targeting 0.4155378354437235 0.5566004544810523 0.5778004431954449 1.0 1.0 24 O95376,P31751,P55786 3 +Regulation of protein acetylation 0.4173696476053506 0.5563780942650826 0.5779524107666931 1.0 1.0 23 Q12824,O00571,Q9NPI1,Q969T9,Q96ST2,O75844,Q01105 7 +Regulation of neurogenesis 0.3089400643231527 0.555351263847434 0.5786544209559819 1.0 1.0 56 Q8N0X7,O14744,Q96G23,P43034,Q9H2U1,Q9UQB8,Q00535,Q15154,P55209,Q7L576,Q9UPY3,P21359,Q08209,P42345 14 +Muscle system process 0.2997891286827865 0.5547126616464758 0.5790912142721818 1.0 1.0 52 P17612,P60660,Q86U42,P15924,Q96PU5,P50750,Q13555,Q8N335,Q08209,P14923,P42345 11 +Negative regulation of jun kinase activity 0.810979618671926 0.5544700692001918 0.5792571840505696 1.0 1.0 2 P31689 1 +Negative regulation of vascular associated smooth muscle cell differentiation 0.810979618671926 0.5544700692001918 0.5792571840505696 1.0 1.0 2 P26358 1 +Positive regulation of nitric oxide synthase activity 0.5132492336643353 0.5521274490972802 0.580861036851642 1.0 1.0 4 Q8WTV0,P31749 2 +Histone h4 r3 methylation 0.8099934253780402 0.5516544373723912 0.5811851319579784 1.0 1.0 2 Q99873 1 +Vacuolar localization 0.4216881908380072 0.5496853759294209 0.5825351890285888 1.0 1.0 16 Q9NVJ2 1 +Base excision repair ap site formation 0.6007892140743134 0.5492865077472833 0.5828088451356279 1.0 1.0 3 P78549,P29372 2 +Regulation of rna export from nucleus 0.4142095089612759 0.5490668800653268 0.5829595532401473 1.0 1.0 9 Q96ST2,Q07666 2 +Apoptotic process involved in heart morphogenesis 0.8090072320841739 0.548844226393043 0.5831123563259175 1.0 1.0 2 Q12948 1 +Positive regulation of sphingolipid biosynthetic process 0.809007232084153 0.5488442263929825 0.583112356325959 1.0 1.0 2 Q05655 1 +Regulation of sphingolipid biosynthetic process 0.809007232084153 0.5488442263929825 0.583112356325959 1.0 1.0 2 Q05655 1 +Myeloid leukocyte cytokine production 0.4140721898154363 0.5484308867565091 0.5833960731599879 1.0 1.0 9 Q96EB6,Q9H2U1,Q92499,P14174,Q7Z434 5 +Positive regulation of dna demethylation 0.6004125593534619 0.5480700036354474 0.5836438363744727 1.0 1.0 3 Q93008 1 +Peptidyl serine dephosphorylation 0.4308773838647013 0.5471972238722352 0.5842432432262483 1.0 1.0 8 P63151,Q08209,P30153 3 +Coenzyme a metabolic process 0.447978485688339 0.5464990325028217 0.5847229525902555 1.0 1.0 7 Q9NVE7 1 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.4207349391749312 0.5450563433141291 0.5857147670837555 1.0 1.0 16 Q9UQ84 1 +Somatic diversification of immunoglobulins involved in immune response 0.4207349391749312 0.5450563433141291 0.5857147670837555 1.0 1.0 16 Q9UQ84 1 +B cell activation involved in immune response 0.4207349391749312 0.5450563433141291 0.5857147670837555 1.0 1.0 16 Q9UQ84 1 +Response to uv a 0.5110932813852069 0.544304020671002 0.5862322806082507 1.0 1.0 4 P31749 1 +Maintenance of dna repeat elements 0.5108341966412087 0.5433662466420223 0.5868776606194541 1.0 1.0 4 O75844 1 +Positive regulation of protein tyrosine kinase activity 0.4875218113575844 0.5431733079810571 0.5870104826266764 1.0 1.0 5 Q15334 1 +Positive regulation of cytokine production involved in immune response 0.4145210345563606 0.5419528939251976 0.5878509572117314 1.0 1.0 10 Q96EB6,Q9H2U1,Q92499,P14174,Q7Z434 5 +Development of primary female sexual characteristics 0.418429888992341 0.5416573908814586 0.5880545478648809 1.0 1.0 13 Q96EB6,O94813,Q13144,Q12948,O75874,P49770 6 +Response to salt 0.597829661295623 0.5397531672571547 0.5893672685209279 1.0 1.0 3 Q14103,P09651 2 +Heart trabecula morphogenesis 0.8057199211045345 0.539516403578454 0.5895305814715048 1.0 1.0 2 P62942 1 +Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.5975219553164334 0.538765333409732 0.5900487866564492 1.0 1.0 3 Q9H2U1 1 +Pseudopodium organization 0.8053911900065749 0.538586996997583 0.5901718617103262 1.0 1.0 2 P25054 1 +Positive regulation of pseudopodium assembly 0.8053911900065749 0.538586996997583 0.5901718617103262 1.0 1.0 2 P25054 1 +Purine nucleobase biosynthetic process 0.4283676800057151 0.5361382813862507 0.5918629847241659 1.0 1.0 8 P34897 1 +Regulation of ras protein signal transduction 0.3950976890156855 0.5358023406723527 0.5920951643344763 1.0 1.0 30 P41440,P22681,P21359,Q15555,Q68EM7 5 +Membrane disassembly 0.4854071021653138 0.5351233931495785 0.592564534738727 1.0 1.0 5 Q9ULX6,P43034 2 +Negative regulation of signal transduction by p53 class mediator 0.4624859447376277 0.5346939621515503 0.5928614972978101 1.0 1.0 6 Q96QE3 1 +Regulation of protein polymerization 0.3220387662434052 0.5335880725748084 0.5936265621731691 1.0 1.0 63 P04350,Q7Z460,Q96F07,O95429,O94813,Q16625,P16333,Q05655,Q9UQB8,P61586,O15511,Q13045,Q7L576,P42345,Q9NUQ9,P35080,P36404,Q96J84 18 +Gene silencing by rna 0.3263693733064891 0.5332965610950285 0.5938283078097151 1.0 1.0 43 P62826,P17844,P22626,Q5T280,Q08209,Q9HCE1,Q01085,Q9UGR2,Q06787,Q9BWF3,Q9UPY3,Q92879,A5YKK6,P51114,O00571,Q15631,O75844,P40763,Q92600,Q13546,Q9HAV4,P42694 22 +Response to pain 0.5955644102603258 0.5324959668448733 0.5943825344376368 1.0 1.0 3 P42345 1 +Behavioral response to pain 0.5955644102603258 0.5324959668448733 0.5943825344376368 1.0 1.0 3 P42345 1 +Dna dealkylation 0.4102663639739263 0.5308718601616919 0.5955075789571522 1.0 1.0 9 Q93008,Q13263,Q93009,Q8N3C0,P27695 5 +Regulation of circadian rhythm 0.4103289420067152 0.5291649313826459 0.596691041535736 1.0 1.0 24 Q96ST3,Q13148,Q13330,Q93008,P23246,Q9BWF3,Q93009,P42345,P78527,Q9Y2K7,Q15233 11 +Histone monoubiquitination 0.4115514651880315 0.5282045832859243 0.597357348620722 1.0 1.0 10 Q16531,Q6PD62,Q99496,Q6W2J9,P63208 5 +Regulation of cyclin dependent protein kinase activity 0.41725405243392 0.5280802818606947 0.5974436159449923 1.0 1.0 17 O00410,P20248,P25054,Q9P287,Q16543,P49736,O75832,P14635,Q9BZE4,P31749,P53350,O95067 12 +Regulation of aerobic respiration 0.415688588631029 0.5248492377347893 0.5996879999653153 1.0 1.0 14 Q9BSK2 1 +Regulation of anion transport 0.4121248835649883 0.5234241215018519 0.6006791417662916 1.0 1.0 11 Q7L0J3,Q9HD26,O43865,P14174 4 +Regulation of gene silencing by rna 0.4153340560836439 0.5221702092393063 0.6015518261103621 1.0 1.0 19 Q06787,P17844,P40763,Q13546,O75844,Q08209 6 +Cerebral cortex cell migration 0.4117641385045962 0.521753548763241 0.6018419355484765 1.0 1.0 11 P07942,P43034,P61586,Q00535 4 +Positive regulation of erythrocyte differentiation 0.4116733800010539 0.5213334589937931 0.6021344965666344 1.0 1.0 11 Q15648,P40763,Q99873,P78527 4 +Regulation of blood pressure 0.4157820917469343 0.5211600422683254 0.6022552869983366 1.0 1.0 16 Q9UIQ6,Q9HB40,Q9NZ08,O75787 4 +Lymphoid progenitor cell differentiation 0.7991452991452974 0.5210470697848902 0.6023339819076445 1.0 1.0 2 P78527 1 +Pro b cell differentiation 0.7991452991452974 0.5210470697848902 0.6023339819076445 1.0 1.0 2 P78527 1 +Regulation of mrna export from nucleus 0.4816338094524942 0.5208496220594119 0.6024715321053626 1.0 1.0 5 Q96ST2 1 +Central nervous system projection neuron axonogenesis 0.7988165680473364 0.5201302488318034 0.6029727966830489 1.0 1.0 2 P43034 1 +Negative regulation of leukocyte chemotaxis 0.7988165680473338 0.5201302488317967 0.6029727966830536 1.0 1.0 2 P14174 1 +Protein targeting to membrane 0.3922934034047137 0.5198386020103176 0.6031760717960881 1.0 1.0 30 Q9UNL2,O43765,O60725,Q9UHD1,O76094,Q15629,Q00535,P31751,Q7L5D6,Q9UHB9,Q9H9H4,P40855 12 +Purine nucleobase metabolic process 0.4077766202080012 0.5194575242824185 0.6034417258605187 1.0 1.0 9 P34897 1 +Positive regulation of muscle cell differentiation 0.4586598022368877 0.5194280664623103 0.6034622634666662 1.0 1.0 6 Q96EB6,P42345,Q9BWF3 3 +Negative regulation of fatty acid metabolic process 0.458236822446499 0.5177480468589677 0.6046340707423941 1.0 1.0 6 O00763 1 +Negative regulation of alpha beta t cell activation 0.5035559609388276 0.5172371117018628 0.6049906483975358 1.0 1.0 4 Q13951 1 +Negative regulation of posttranscriptional gene silencing 0.4806729815818054 0.5172337425428585 0.6049930000201487 1.0 1.0 5 O75844 1 +Positive regulation of mitochondrial fission 0.4408956206782933 0.5168426403928298 0.6052660113173729 1.0 1.0 7 P11233,Q96HS1,Q96QK1,O14965,Q8NE86,O00429 6 +Positive regulation of necrotic cell death 0.5034211697080269 0.5167572092175615 0.6053256544282917 1.0 1.0 4 Q13546 1 +Apolipoprotein a i mediated signaling pathway 0.7975016436554888 0.516469390375608 0.6055266122925014 1.0 1.0 2 P61586 1 +Positive t cell selection 0.797172912557534 0.5155557878733786 0.606164696144093 1.0 1.0 2 P42345 1 +Cd4 positive or cd8 positive alpha beta t cell lineage commitment 0.797172912557534 0.5155557878733786 0.606164696144093 1.0 1.0 2 P42345 1 +T helper cell lineage commitment 0.797172912557534 0.5155557878733786 0.606164696144093 1.0 1.0 2 P42345 1 +Protein homooligomerization 0.3494358927544709 0.5150055040660568 0.606549173818955 1.0 1.0 39 Q13085,P34897,Q6DD88,P35637,Q99720,O00763,Q9Y3Z3,Q14168,P34896 9 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4099477271462813 0.5133617084371698 0.6076983256702313 1.0 1.0 11 O60506,A5YKK6,Q9H2U1 3 +Cellular hormone metabolic process 0.4136467664743505 0.5109405556928893 0.6093926818665516 1.0 1.0 16 O60678,Q15648,Q8TC12,Q9HB40,Q14849 5 +Negative regulation of blood vessel endothelial cell migration 0.4789747284059575 0.510861738339094 0.6094478746303786 1.0 1.0 5 P61586,P14923 2 +Response to reactive oxygen species 0.3599635465703204 0.5108348717894609 0.6094666887504714 1.0 1.0 37 O95831 1 +Smooth muscle contraction 0.4392153737758724 0.5098721054771446 0.6101410655423638 1.0 1.0 7 Q86TU7,Q14247,P61586 3 +Mitotic recombination 0.4073422600744382 0.5088625082440071 0.6108486010675152 1.0 1.0 10 P18074,Q8IY18,P18887 3 +Cap dependent translational initiation 0.5875080596406952 0.5069735017074128 0.6121734113100508 1.0 1.0 3 P16333 1 +Apical junction assembly 0.4104966936786819 0.5066831544823824 0.6123771521313182 1.0 1.0 21 P17612,P25054,Q16625,P61586,O43815,P36404 6 +Negative regulation of vascular permeability 0.5869779677737464 0.5053103355435516 0.6133408846254227 1.0 1.0 3 Q02952,O94813 2 +Protein peptidyl prolyl isomerization 0.408956416646326 0.505140179607912 0.6134603823883706 1.0 1.0 22 O95302,P62942,Q9Y680,Q9NWM8,Q8WUA2,P26885,Q13526 7 +Dna methylation or demethylation 0.4073506381104346 0.5045623592331301 0.6138662529459098 1.0 1.0 23 Q8NB78,O75844 2 +Hormone metabolic process 0.3895239772462453 0.5042027802101247 0.614118886925864 1.0 1.0 30 O60678,Q06520,Q15648,Q9HB40,O75787,Q8TC12,O75844,Q9UBM7,Q14849 9 +Heart growth 0.4071818051059775 0.500647802048545 0.6166190140677608 1.0 1.0 11 Q12948 1 +T cell differentiation 0.4044529622461565 0.4986550593562946 0.6180224095915063 1.0 1.0 24 P24390,P62753,P40763,P61586,O14617,Q13951,P78527,P0CG08,P42345 9 +Negative regulation of transmembrane transport 0.4076672589320818 0.49864378931195 0.6180303505285665 1.0 1.0 22 Q9HD26,P31751 2 +Protein acylation 0.3067105134417409 0.4984041219185072 0.6181992320951637 1.0 1.0 58 Q12824,Q9NRF9,O75448,O75844,Q9BXJ9,Q86UY6,O00571,Q9NPI1,Q969T9,Q9Y6J9,Q96ST2,Q8IY18,Q01105,Q9Y4A5 14 +Membrane protein proteolysis 0.4066685806843406 0.4982974725260921 0.6182743890483751 1.0 1.0 11 O43847,Q9NZ08 2 +Optic nerve development 0.7902695595003489 0.4965214081120283 0.6195265870217468 1.0 1.0 2 Q9H061 1 +Dicarboxylic acid transport 0.4102191497225325 0.4946454107175694 0.6208504414997342 1.0 1.0 16 P41440 1 +Vascular associated smooth muscle cell proliferation 0.4022869673279446 0.4945034304772874 0.6209506842365595 1.0 1.0 9 Q53EL6,P26358,P61586,Q9Y2S7 4 +Cell cell junction assembly 0.3910111474028322 0.4940758016593233 0.6212526468160962 1.0 1.0 29 P17612,P25054,Q16625,P61586,O43815,P19022,P14923,P36404 8 +Copii coated vesicle cargo loading 0.4180585116966738 0.4913142990206423 0.6232041680069091 1.0 1.0 8 P53992,O95487 2 +Thymus development 0.4180241836874458 0.4911667455132062 0.6233085169905515 1.0 1.0 8 O95067 1 +Eye morphogenesis 0.4049091075527731 0.4902611735605816 0.6239490977889339 1.0 1.0 11 P21359 1 +Coenzyme a biosynthetic process 0.4732646780224347 0.4896199939161829 0.6244028255716498 1.0 1.0 5 Q9NVE7 1 +Histone ubiquitination 0.4079268000101156 0.4892449134813186 0.624668315545176 1.0 1.0 20 P50750,Q6PD62,Q96FW1,Q6W2J9,P63208 5 +Negative regulation of mrna metabolic process 0.3332070334675429 0.4870230124159114 0.6262420230019465 1.0 1.0 41 P61978,Q92804,P26368,P35637,P50750,Q6PD62,O60506,P22626,Q14011 9 +Positive regulation of growth 0.3128792842848183 0.4846740355650529 0.6279075872076638 1.0 1.0 44 O95684,P43034,Q96PU5,Q96K76,P61586,Q7Z4V5,Q7L576,O00571,O00763,Q9Y6V7,Q9BSK2,P31749 12 +Cellular response to acid chemical 0.406461177212464 0.4816608713923665 0.6300468765911522 1.0 1.0 14 Q9UQB8,P42345 2 +Regulation of cation channel activity 0.407372634614036 0.4812186340498567 0.6303611185426332 1.0 1.0 16 P17612,P42858,P07384,Q00535,Q15334,P62942,P27695 7 +Molting cycle 0.4069295474796337 0.4808984608274559 0.6305886667577183 1.0 1.0 15 P21359,P18074,O75844 3 +Leukocyte differentiation 0.3022807223222095 0.4801706248383471 0.63110607264076 1.0 1.0 57 P24390,Q14739,P62753,P43034,P40763,P61586,Q15648,Q13951,P60953,P12956,Q13546,O00625,P78527,P21359,P0CG08,P42345 16 +Viral release from host cell 0.4070646516614672 0.4798732724864363 0.6313175072796224 1.0 1.0 18 P11498,Q9NVJ2 2 +Sphingomyelin metabolic process 0.4319054391987341 0.4798531509526409 0.6313318159385162 1.0 1.0 7 O15270,P22059 2 +Regulation of epithelial cell migration 0.3191320227911088 0.4797742132591197 0.6313879507931357 1.0 1.0 43 P67870,Q05397,Q8WTV0,P57105,O94813,P61586,P21359,P14923,Q15555,P35080,P31749,P42345 12 +Positive regulation of gluconeogenesis 0.5781946162910789 0.4780549453138699 0.6326110984127746 1.0 1.0 3 Q16531 1 +Positive regulation of cytoskeleton organization 0.2884254336855372 0.4768168598194217 0.633492538988506 1.0 1.0 51 Q7Z460,P48681,O95429,Q16625,P16333,Q9UQB8,P61586,Q00535,P60953,Q7L576,P42345,P35080,P36404,Q96J84 14 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.4920090655304929 0.4766832207685211 0.6335877128996725 1.0 1.0 4 Q96EB6,P14174 2 +Negative regulation of epithelial cell proliferation 0.4002405937090852 0.4766393785737158 0.6336189373781993 1.0 1.0 10 Q15648,P21359,P57105 3 +Regulation of leukocyte proliferation 0.3958938785234056 0.4760802536354961 0.6340172042255476 1.0 1.0 26 Q05397,Q5ZPR3 2 +Camera type eye development 0.3689017970481969 0.4760383732102754 0.6340470400833353 1.0 1.0 34 P21359,Q15555,Q12948 3 +Sphingomyelin biosynthetic process 0.4914673084680759 0.4748091240650008 0.6349230290880923 1.0 1.0 4 P22059 1 +Positive regulation of epithelial cell proliferation 0.3997322288811488 0.4745041915981 0.63514040963826 1.0 1.0 24 P07942,Q15648,P60953,P22392,P21359,Q9H2J4,P31749 7 +Locomotory exploration behavior 0.7820512820512777 0.4742483969673143 0.6353227850218213 1.0 1.0 2 Q15334 1 +Mononuclear cell differentiation 0.3248661843001011 0.4733318860767537 0.6359764167075133 1.0 1.0 42 P24390,P62753,P40763,P61586,Q15648,Q13951,P12956,O00625,P78527,P0CG08,P42345 11 +Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity 0.7800788954635043 0.4689673258889206 0.639092991200114 1.0 1.0 2 P42858 1 +Axonal transport 0.4035943671781845 0.4681503838649596 0.6396770508136835 1.0 1.0 20 Q9NZ32,P43034,Q9NVJ2,Q92572,Q14168,P27695,O60333 7 +Positive regulation of protein polymerization 0.3755858806103531 0.4667888285799864 0.640650969277905 1.0 1.0 32 Q7Z460,O95429,Q16625,P16333,Q9UQB8,P61586,P42345,P35080,P36404,Q96J84 10 +Positive regulation of cytoplasmic translation 0.3988447220849286 0.462823403111023 0.643490954721174 1.0 1.0 11 O60506 1 +Glial cell proliferation 0.4659365108956547 0.4627907142992798 0.6435143877456864 1.0 1.0 5 Q96G23 1 +Ventricular septum morphogenesis 0.7771203155818535 0.4610935377540083 0.6447314978765537 1.0 1.0 2 O94813 1 +Atrial septum morphogenesis 0.7771203155818527 0.4610935377540074 0.6447314978765544 1.0 1.0 2 P20248 1 +Atrial septum development 0.7771203155818527 0.4610935377540074 0.6447314978765544 1.0 1.0 2 P20248 1 +Cardiac atrium morphogenesis 0.7771203155818527 0.4610935377540074 0.6447314978765544 1.0 1.0 2 P20248 1 +Regulation of dendritic cell differentiation 0.5723391906428207 0.4602130502669211 0.6453633046504899 1.0 1.0 3 P09429 1 +Neuronal action potential 0.4650507281612467 0.459582025538272 0.6458162632878146 1.0 1.0 5 Q06787,P42345,Q7Z406 3 +Regulation of peptidyl lysine acetylation 0.4004266057352384 0.4570564459206422 0.6476304744727768 1.0 1.0 21 Q12824,Q9NPI1,Q969T9,Q96ST2,O75844,Q01105 6 +Establishment of sister chromatid cohesion 0.4856015977792697 0.4546901842357306 0.6493321435584944 1.0 1.0 4 Q7Z5K2,Q9Y6X3 2 +Cytokine production involved in immune response 0.3969883434810098 0.454508397278864 0.6494629493641058 1.0 1.0 11 Q96EB6,Q9H2U1,Q92499,P14174,Q7Z434,P04439 6 +Intermediate filament organization 0.4409551970512135 0.4505040024490032 0.652347068855311 1.0 1.0 6 P15924,Q15149,P08670,P58107 4 +Regulation of cell aging 0.3943086899628545 0.450147313192935 0.6526042233409244 1.0 1.0 10 O75844,O43324 2 +Base excision repair 0.4002075065645397 0.4489991745993887 0.6534322520680631 1.0 1.0 19 Q07864,Q96K76,P27694,P18887,P27695 5 +Forebrain cell migration 0.3971938722477212 0.4489590263404654 0.6534612144150362 1.0 1.0 12 P07942,P43034,P61586,Q00535 4 +Mitotic dna replication checkpoint signaling 0.5685629727063316 0.4488515013755421 0.6535387838702609 1.0 1.0 3 Q13564,Q92547 2 +Telomere maintenance via recombination 0.4403977885556054 0.4483832339765889 0.6538766397343081 1.0 1.0 6 P18887 1 +Cellular response to prostaglandin stimulus 0.4831261364858762 0.4462964046891141 0.6553831529800374 1.0 1.0 4 Q13085 1 +Response to prostaglandin 0.4831261364858762 0.4462964046891141 0.6553831529800374 1.0 1.0 4 Q13085 1 +Negative regulation of mrna catabolic process 0.3968390163423173 0.4450102304798762 0.6563123608904229 1.0 1.0 22 Q92804,Q14011,P35637 3 +Positive regulation of cell growth 0.3544632438193517 0.4449922875828793 0.6563253276601912 1.0 1.0 36 O95684,P43034,Q96PU5,Q96K76,P61586,Q7Z4V5,Q7L576,O00571,Q9Y6V7,Q9BSK2,P31749 11 +Positive regulation of maintenance of sister chromatid cohesion 0.5669585719087886 0.4440595326866034 0.6569995429205135 1.0 1.0 3 Q8IY18 1 +Negative regulation of cell projection organization 0.3846661078938314 0.4439899320014462 0.6570498629942243 1.0 1.0 28 Q8N0X7,Q96G23,P43034,Q05655,P61586,Q86X55,Q00535,P35080,Q08209 9 +Centromere complex assembly 0.4228173909461823 0.4432727414826737 0.6575684696828741 1.0 1.0 7 Q92674 1 +Histone h3 k36 demethylation 0.7698882314266872 0.4420929092695985 0.6584219752576006 1.0 1.0 2 Q8IUF8 1 +Protein o linked glycosylation via threonine 0.7695595003287307 0.4412376949418292 0.6590409265713739 1.0 1.0 2 Q10471 1 +Antigen processing and presentation of peptide antigen via mhc class i 0.3939902231804936 0.4411660657406198 0.6590927779709199 1.0 1.0 11 Q9NZ08 1 +Cardiac muscle cell action potential 0.3975390141582004 0.4408512981907047 0.659320653315441 1.0 1.0 14 P15924,Q96PU5,P14923 3 +Positive regulation of viral life cycle 0.4060799303554911 0.4405728781644638 0.6595222412995183 1.0 1.0 8 Q06787,P19474,Q99816,Q9H9H4 4 +Endocrine pancreas development 0.4810459430588892 0.439288552302764 0.6604524679933459 1.0 1.0 4 P31749 1 +Pigmentation 0.3978817476240884 0.4362867218179535 0.6626287144860477 1.0 1.0 17 P21359,P62820,O75787,O14617 4 +Skeletal system morphogenesis 0.3978213774963174 0.4360083169566202 0.6628306952985747 1.0 1.0 17 Q12948,O75844,Q93074 3 +Positive regulation of ire1 mediated unfolded protein response 0.562643867148958 0.4312788050552085 0.6662656595782601 1.0 1.0 3 Q07812,P57088 2 +Positive regulation of endoplasmic reticulum unfolded protein response 0.562643867148958 0.4312788050552085 0.6662656595782601 1.0 1.0 3 Q07812,P57088 2 +Regulation of perk mediated unfolded protein response 0.5626438671489512 0.4312788050551881 0.666265659578275 1.0 1.0 3 P16333,P57088 2 +Positive regulation of peptidyl serine phosphorylation 0.3958919358913264 0.4286977585020219 0.66814319208307 1.0 1.0 19 Q9H7B4 1 +Positive regulation of nervous system development 0.3304877607224178 0.4281035116638303 0.6685757602255498 1.0 1.0 40 O14744,O94813,P43034,Q9H2U1,Q9UQB8,P55209,Q7L576,Q9UPY3,P42345 9 +Leukocyte mediated immunity 0.2757708849496061 0.4280056399951636 0.6686470141860952 1.0 1.0 48 Q96QE3,Q07021,P22681,Q9H2U1,Q9NVJ2,Q05655,Q9UQ84,Q7Z434 8 +Cellular amino acid biosynthetic process 0.3647663846384334 0.4278183637922892 0.6687833660601077 1.0 1.0 33 Q13126,P78330,P34897,Q9NRN7 4 +Negative regulation of leukocyte cell cell adhesion 0.3936252692437378 0.4276223676474038 0.6689260784407294 1.0 1.0 13 Q92990,Q96J02,Q13951,P31749 4 +Mitochondrial fragmentation involved in apoptotic process 0.4560710760118627 0.4274919748819251 0.6690210290874041 1.0 1.0 5 Q07812,Q8N163,Q96QK1,Q9NT62 4 +Regulation of mrna polyadenylation 0.393474993321982 0.4269540485484216 0.6694127973549784 1.0 1.0 13 Q96MU7,P50750,Q6PD62 3 +Positive regulation of g0 to g1 transition 0.7639710716633772 0.4268138066859682 0.6695149493880481 1.0 1.0 2 Q15648 1 +Lymphocyte homeostasis 0.3888864617465817 0.4262935467806009 0.6698939595901838 1.0 1.0 10 P62753,P31749,O95067 3 +Outflow tract morphogenesis 0.3866754409983869 0.4253070755628703 0.6706128362583486 1.0 1.0 9 O95487,Q12948,Q13418 3 +Spermine metabolic process 0.7629848783694875 0.4242911536590454 0.6713534899972082 1.0 1.0 2 P52788 1 +Photoperiodism 0.4546286647967678 0.4224140223647848 0.672722844583741 1.0 1.0 5 Q9BWF3 1 +Entrainment of circadian clock 0.4546286647967678 0.4224140223647848 0.672722844583741 1.0 1.0 5 Q9BWF3 1 +Protein localization to mitochondrion 0.2928516667940941 0.4218057321123399 0.6731668214319484 1.0 1.0 56 O95376,O95831,O95429,O60830,Q9NS69,P55786 6 +Cell fate commitment 0.3937584592904793 0.4212532837141804 0.673570139340492 1.0 1.0 20 P25054,P61586,Q6PD62,P60953,P61026,P78527,P42345 7 +Ephrin receptor signaling pathway 0.4168236574578782 0.4196315918052085 0.6747546060367295 1.0 1.0 7 Q05397,P16333,Q92625 3 +Regulation of generation of precursor metabolites and energy 0.3402018249355739 0.4195373929472826 0.6748234326940885 1.0 1.0 38 Q9NZ45,P34897,P61586,O75746,P31751,Q9BSH4,Q9BSK2,P31749,P36404 9 +Vocalization behavior 0.7610124917817169 0.4192665767333423 0.6750213204629119 1.0 1.0 2 Q15334 1 +Regulation of bone mineralization 0.4166743155027474 0.4190477027163157 0.675181270035045 1.0 1.0 7 O75844,Q6W2J9 2 +Regulation of vasculature development 0.3669506940354082 0.4184931926160309 0.6755865626509445 1.0 1.0 32 P21359,Q12948,Q9NZ08,P57105 4 +Regulation of osteoclast differentiation 0.4746725303443087 0.4180842497075673 0.6758855201658482 1.0 1.0 4 P21359 1 +Neuroblast proliferation 0.3886811218952268 0.4178122935009692 0.676084361922189 1.0 1.0 11 P21359,P61026 2 +Regulation of biomineralization 0.3833054565960584 0.4107473743044265 0.68125778520519 1.0 1.0 9 O75844,Q6W2J9 2 +Positive regulation of phosphoprotein phosphatase activity 0.4302318187609504 0.4102803365267213 0.681600314770447 1.0 1.0 6 P42345 1 +Positive regulation of phosphatase activity 0.4302318187609504 0.4102803365267213 0.681600314770447 1.0 1.0 6 P42345 1 +Adherens junction organization 0.3884092514666021 0.4100904831002331 0.6817395736920624 1.0 1.0 12 P15924 1 +Regulation of cell projection assembly 0.281202059343886 0.4098517523374007 0.6819146998975625 1.0 1.0 47 O15144,O94813,Q9P258,P42858,Q16625,Q06787,P25054,Q05655,P51114,P60953,Q7L576,P42345,Q15555,P35080,P27695,Q4KMP7 16 +Receptor clustering 0.3881389489080899 0.4089105181967626 0.6826053298042511 1.0 1.0 12 Q14168,P19022,P57105,Q15334 4 +Regulation of long term neuronal synaptic plasticity 0.4716101936498068 0.4080429993962052 0.6832421065864112 1.0 1.0 4 P21359 1 +Maintenance of sister chromatid cohesion 0.4294066160667834 0.4072369561565144 0.6838339610921638 1.0 1.0 6 Q9Y6X3 1 +Erbb signaling pathway 0.3860371852508283 0.4064464967560118 0.6844145615420791 1.0 1.0 24 Q05397,P22681,P51452,Q96EY5,P31749,Q99816 6 +Regulation of neuronal synaptic plasticity 0.3973131249064391 0.4044591128314773 0.6858751387193136 1.0 1.0 8 P21359,Q15334 2 +Regulation of neuron projection development 0.3187425238303142 0.403229441580816 0.6867794427593019 1.0 1.0 69 Q8N0X7,P98155,Q9UQB8,Q86X55,Q08209,P43034,Q9H2U1,P61586,Q32P28,Q96PU5,Q00535,Q7L576,P31749,Q12834,O94813,Q96G23,P19022,O60828,Q9H4M9,Q13555 20 +Negative regulation of collateral sprouting 0.7544378698224967 0.4027204121849366 0.6871539158736419 1.0 1.0 2 Q8N0X7 1 +Positive regulation of b cell proliferation 0.4699480622252118 0.4026340008864114 0.6872174929275725 1.0 1.0 4 Q96QE3 1 +Positive regulation of megakaryocyte differentiation 0.5517921736270887 0.3998431120774835 0.6892720746792416 1.0 1.0 3 P26583,Q9UKL0 2 +Protein localization to cell junction 0.3895373797323105 0.3982359481465945 0.690456269864909 1.0 1.0 18 Q14168,P15924,Q9UQB8,Q9UDY2 4 +Mammary gland development 0.3869750307923777 0.3977333137774679 0.6908267781330621 1.0 1.0 22 Q13505,P07384,P31751,Q9UNS2,P31749 5 +Negative regulation of viral transcription 0.7514792899408251 0.3953779290715332 0.6925639950215745 1.0 1.0 2 Q4G0J3 1 +Regulation of muscle contraction 0.3884179729371096 0.3945125389949839 0.6932026715512742 1.0 1.0 16 P17612,P15924 2 +Negative regulation of circadian rhythm 0.7508218277448988 0.39375509765761 0.6937618585751015 1.0 1.0 2 Q96ST3 1 +Gliogenesis 0.2914561833099505 0.3936112954928124 0.6938680405022051 1.0 1.0 57 O14744,Q96G23,P07942,P43034,Q96P11,P61586,O75306,Q00535,Q93074,Q13418,P18074,P31751,P19022,Q9UPY3,P21359,P31749,P42345,P49770 18 +Maintenance of synapse structure 0.4256257034449671 0.3933920585841774 0.6940299341752398 1.0 1.0 6 Q15334,Q9BRK5 2 +Dna modification 0.368319552133205 0.3892739454055989 0.6970735078680033 1.0 1.0 30 Q8NB78,O75844 2 +Telencephalon development 0.3124604855731093 0.3883609141654889 0.6977489646783306 1.0 1.0 42 O14949,O43776,O94813,P07942,P43034,Q96P11,P61586,Q00535,P62995,P19022,Q96QD8,P18887,P21359,Q9H0D6 14 +Regulation of establishment or maintenance of cell polarity 0.4086318814618605 0.3879913087272284 0.6980224654242968 1.0 1.0 7 Q15334,Q96Q89 2 +Regulation of wound healing 0.3868869104849995 0.3877322341754506 0.6982141988756125 1.0 1.0 16 Q05397,Q9Y251,Q16625,P42345 4 +Protein import into mitochondrial matrix 0.3778282562753619 0.3873961293228643 0.6984629688864594 1.0 1.0 9 O60830 1 +Cellular response to exogenous dsrna 0.3930246225214989 0.3871359128213185 0.6986555919310455 1.0 1.0 8 Q7Z434,P41440 2 +Purine nucleotide transport 0.3809367606553168 0.3844094791727325 0.700674975895027 1.0 1.0 11 P41440 1 +Pallium development 0.3235924014309161 0.3839850227504659 0.7009895482839148 1.0 1.0 40 O14949,O43776,O94813,P07942,P43034,Q96P11,P61586,Q00535,P62995,P19022,Q96QD8,P18887,P21359,Q9H0D6 14 +Tolerance induction 0.4639051021334095 0.3832181826798815 0.7015579973970076 1.0 1.0 4 Q96J02,P09429 2 +Positive regulation of g1 s transition of mitotic cell cycle 0.3858559972462574 0.38318710100311 0.7015810413868064 1.0 1.0 16 Q7L2J0,Q96DY7,P23921,O00571,O43660,P31749,P27695 7 +Negative regulation of smooth muscle cell proliferation 0.4224674659995471 0.3819549159790343 0.7024948056493825 1.0 1.0 6 Q53EL6,Q15637,P61586 3 +Positive regulation of vasculature development 0.3857592917235981 0.381453675350953 0.7028666390235783 1.0 1.0 17 P14923,Q9H2J4,Q86UE4,Q9NZ08 4 +Regulation of cardiac muscle cell action potential 0.4067492729958987 0.3808347940036026 0.703325839434469 1.0 1.0 7 P15924 1 +Negative regulation of calcineurin mediated signaling 0.7452333990795678 0.380092328980556 0.7038768798354387 1.0 1.0 2 P42345 1 +Negative regulation of calcium mediated signaling 0.7452333990795678 0.380092328980556 0.7038768798354387 1.0 1.0 2 P42345 1 +Regulation of sodium proton antiporter activity 0.7452333990795543 0.3800923289805241 0.7038768798354624 1.0 1.0 2 O43707 1 +Protein deubiquitination involved in ubiquitin dependent protein catabolic process 0.7445759368836453 0.3785005343230304 0.7050587969111064 1.0 1.0 2 Q6GQQ9 1 +Protein kinase a signaling 0.4211583485464941 0.3772489628193157 0.7059885965977608 1.0 1.0 6 P17612 1 +Regulation of nucleocytoplasmic transport 0.3106779981096572 0.3766096332591427 0.7064637277376611 1.0 1.0 42 P17612,Q9ULX6,O00410,P62826,Q9UHD1,Q92688,Q05655,Q00535,Q9BWF3,O14980,Q7Z434,O95071,Q96ST2,P21359,Q07666,P14923 16 +Negative regulation of response to dna damage stimulus 0.3760316766648987 0.375916123180158 0.7069792536283117 1.0 1.0 26 Q96QE3,Q96K76,Q96FW1,P18887,O95071 5 +Pyrimidine nucleoside triphosphate metabolic process 0.380396085842925 0.3755410542007295 0.7072581199714929 1.0 1.0 12 P22392,Q9H773,P17812 3 +Dicarboxylic acid metabolic process 0.3329102405976611 0.3752727138593205 0.7074576569521693 1.0 1.0 38 P41440,P48735,P34897,Q9H2D1,O75746,O75874,Q9NRN7,P48163,P34896 9 +I kappab phosphorylation 0.41965664445404 0.371876264871815 0.7099849777150748 1.0 1.0 6 P31749,Q8IUD2 2 +Regulation of gene expression epigenetic 0.3158943779550432 0.371638359304651 0.7101621248599321 1.0 1.0 41 Q92990,Q8NB78,Q96ST3,P24941,P26358,Q6PD62,O14497,Q969T9,Q9NRF9 9 +Regulation of alpha beta t cell activation 0.3760750059234383 0.3714346497714354 0.710313821703819 1.0 1.0 10 Q13951,P61586,Q96J02,O14617 4 +Polysaccharide biosynthetic process 0.3805210726633491 0.3705165468877709 0.7109976498432011 1.0 1.0 13 P31751,Q7LGA3 2 +Regulation of transcription regulatory region dna binding 0.3773264342792344 0.3691225161869558 0.7120364067020413 1.0 1.0 11 Q12948,Q96ST3,O75844 3 +T cell differentiation in thymus 0.4033717106038521 0.3681074245248817 0.7127931350282966 1.0 1.0 7 P78527 1 +Ventricular septum development 0.3882189830263789 0.3680072335161209 0.7128678405494155 1.0 1.0 8 O94813,P20248 2 +Regulation of execution phase of apoptosis 0.4582236842105418 0.3653317863110401 0.7148637537101519 1.0 1.0 4 O00273,P63167,Q13177 3 +Cohesin loading 0.5392653535484397 0.3648840979261208 0.7151979251507321 1.0 1.0 3 Q9Y6X3 1 +Hematopoietic stem cell differentiation 0.3762068200890124 0.3644202009380304 0.7155442528947269 1.0 1.0 11 P18074,Q12948,P78527 3 +Regulation of mrna 3 end processing 0.3818782356609161 0.3643796687135622 0.7155745154852846 1.0 1.0 17 O43865,Q9H2U1,P50750,Q6PD62,Q96MU7 5 +Response to electrical stimulus 0.4374651271219566 0.3637431340992276 0.7160498301703391 1.0 1.0 5 Q14103,Q7L576 2 +Determination of adult lifespan 0.4173508215871254 0.3636805272994807 0.7160965860209041 1.0 1.0 6 O75844,P52701 2 +Roundabout signaling pathway 0.5386044158651254 0.3630809092770262 0.7165444451255447 1.0 1.0 3 P61586 1 +Uv protection 0.4367147745538964 0.3612555938949534 0.7179083862433304 1.0 1.0 5 P18074,Q9BRK5 2 +Chemokine production 0.4011838194560011 0.3599414327753573 0.718890931838559 1.0 1.0 7 O00571,Q7Z434 2 +Positive regulation of chemokine production 0.4011838194560011 0.3599414327753573 0.718890931838559 1.0 1.0 7 O00571,Q7Z434 2 +Presynaptic modulation of chemical synaptic transmission 0.7366863905325407 0.3596597370930912 0.7191016049634977 1.0 1.0 2 Q00535 1 +Production of molecular mediator involved in inflammatory response 0.3779091236086315 0.3594331606753583 0.7192710712647181 1.0 1.0 13 Q53EL6,Q9BWS9,P40763 3 +Small gtpase mediated signal transduction 0.3581803257642711 0.3575264652108582 0.7206977172828763 1.0 1.0 91 Q15392,P80303,P57105,Q96RU2,P41440,P26358,P22681,Q92888,P21359,Q02818,Q92538,Q15555,P49815,Q68EM7 14 +Regulation of mitochondrial atp synthesis coupled electron transport 0.5355979564865394 0.3549323258166609 0.7226402905743523 1.0 1.0 3 Q9H3K2 1 +Female sex differentiation 0.3777340699806625 0.354116460904136 0.7232516063498926 1.0 1.0 14 Q12948,O75874,P49770 3 +Negative regulation of histone acetylation 0.3992042094729786 0.3526071096522672 0.7243830068122894 1.0 1.0 7 Q01105 1 +V d j recombination 0.4136650058197603 0.3507180096998437 0.7257999129793844 1.0 1.0 6 P09429,P78527,Q9Y4B6 3 +Regulation of cellular respiration 0.3788144425456975 0.3506106141752994 0.7258804924916862 1.0 1.0 18 Q9BSK2,P34897,P36404,Q9NZ45 4 +Regulation of synaptic transmission glutamatergic 0.4532949647077087 0.3501143262317138 0.7262528997358269 1.0 1.0 4 P19022 1 +Response to alcohol 0.338092301912585 0.349787309988375 0.7264983233363687 1.0 1.0 36 O95831,P22681,P11802,Q9BRK5,Q13085,P14923 6 +Regulation of signaling receptor activity 0.3766393315771292 0.3494938095123507 0.7267186174744928 1.0 1.0 14 Q15334,P22681,Q05655,P07384 4 +Cell communication involved in cardiac conduction 0.3722677802051817 0.3480250642273798 0.7278213602235728 1.0 1.0 11 P17612,P15924 2 +Positive regulation of cell development 0.2830019188436969 0.3461434892756598 0.7292348814803509 1.0 1.0 56 O14744,O94813,Q07021,Q9H2U1,Q9UQB8,P43034,Q13418,P60953,Q7L576,P55209,P42345,Q9UPY3,P78527,P27695 14 +Negative regulation of phosphorylation 0.3171588315286885 0.3450227088930058 0.7300772985754693 1.0 1.0 72 Q9H7B4,Q16625,P16333,P22681,P31689,P30153,P51452,Q96KB5,P78527,P21359,Q53EL6,Q13217,P25054,P31749,Q96J84,O95684,O94813,P40763,Q05655,P49815,Q8N335,Q99816 22 +Activation of immune response 0.2740589106022538 0.3447721667501033 0.7302656592610788 1.0 1.0 52 Q05397,Q96ST3,Q07021,P51452,Q05655,Q9NRX4,Q5ZPR3,P12956,O60828,P78527,Q7Z434,Q07666,P49770 13 +Regulation of peptidyl serine phosphorylation 0.3694522411739099 0.3444215204607638 0.730529306803146 1.0 1.0 26 Q9H7B4,O95429,Q8N335,P35080,P31749 5 +Polarized epithelial cell differentiation 0.3964757453189876 0.3425844864239634 0.7319110746132558 1.0 1.0 7 P61026,P61586 2 +Positive regulation of keratinocyte differentiation 0.4112851968085588 0.3424408424556259 0.7320191564815683 1.0 1.0 6 P22392,Q12948 2 +Positive regulation of epidermal cell differentiation 0.4112851968085588 0.3424408424556259 0.7320191564815683 1.0 1.0 6 P22392,Q12948 2 +Positive regulation of epidermis development 0.4112851968085588 0.3424408424556259 0.7320191564815683 1.0 1.0 6 P22392,Q12948 2 +Axonal transport of mitochondrion 0.4304658028363831 0.340805954202162 0.733249667729005 1.0 1.0 5 Q9NZ32,P27695 2 +Regulation of response to dna damage stimulus 0.3270197027770493 0.3407063466742394 0.7333246602968515 1.0 1.0 77 Q96QE3,P61978,O43324,Q9NRG4,Q05655,P35637,P50750,Q96K76,Q7Z4V5,Q96FW1,P78527,P14174,P18887,O95071,Q9UNS2,O75844,Q9H993,Q9Y4A5 18 +Mrna alternative polyadenylation 0.4303947334128308 0.3405761638979884 0.7334226762103861 1.0 1.0 5 Q96MU7 1 +Regulation of stem cell population maintenance 0.4501559988587337 0.3405718316583396 0.7334259380716477 1.0 1.0 4 Q9Y6J9 1 +Non motile cilium assembly 0.3700188167319158 0.3387706276442736 0.7347825299647779 1.0 1.0 11 Q15154,Q15555 2 +Negative regulation of myeloid cell differentiation 0.3696190200433228 0.3371337251316504 0.7360160950939014 1.0 1.0 11 Q9GZS3,P21359,Q6PD62 3 +Alcohol metabolic process 0.338791662262212 0.3363224599079257 0.7366277148357172 1.0 1.0 83 Q15392,Q14739,P98155,P48735,P30837,Q06520,Q16850,Q9UBM7,Q14849 9 +Regulation of rna polymerase ii transcription preinitiation complex assembly 0.4483552631579036 0.3351509772662207 0.7375111999695765 1.0 1.0 4 P09429,P62333,P04637 3 +Execution phase of apoptosis 0.3746378637117206 0.3348315854911241 0.7377521326472287 1.0 1.0 16 Q9BXF3,O95831 2 +Gtp biosynthetic process 0.4285360353181274 0.3345890246625133 0.7379351252389401 1.0 1.0 5 P22392,P20839 2 +Regulation of feeding behavior 0.7258382642997991 0.334558625964885 0.7379580596532633 1.0 1.0 2 P40763 1 +Snrna transcription by rna polymerase ii 0.7255095332018362 0.3338128653472814 0.7385207746239881 1.0 1.0 2 Q4G0J3 1 +Snrna transcription 0.7255095332018362 0.3338128653472814 0.7385207746239881 1.0 1.0 2 Q4G0J3 1 +Regulation of snrna transcription by rna polymerase ii 0.7255095332018362 0.3338128653472814 0.7385207746239881 1.0 1.0 2 Q4G0J3 1 +Positive regulation of cytokine production involved in inflammatory response 0.7251808021038754 0.3330679912888167 0.7390829604925744 1.0 1.0 2 P40763 1 +Intermembrane lipid transfer 0.3938517199317277 0.3330415886278889 0.7391028901849441 1.0 1.0 7 Q00169,Q14849 2 +Tetrahydrobiopterin metabolic process 0.4474478123247785 0.3324341505742239 0.7395614549745595 1.0 1.0 4 P00374 1 +Negative regulation of mitotic cell cycle 0.2767338890522467 0.332095976717859 0.7398167880160389 1.0 1.0 54 P24941,Q96DY7,Q96K76,Q92547,Q13642,Q6NUQ1,Q12948,Q9NVX2,Q9NPI1,P78527,P50748 11 +Positive regulation of epithelial cell differentiation 0.3933418859100292 0.3311985567795701 0.7404945102867861 1.0 1.0 7 P22392,Q12948 2 +Negative regulation of translational initiation 0.3932364915978709 0.3308180144791894 0.740781952758274 1.0 1.0 7 Q06787,P40429,P60228,Q9BWF3 4 +Nucleosome assembly 0.3503330107227738 0.3304611839236744 0.7410515174499972 1.0 1.0 32 Q9H7B4,Q99733,P55209,Q9NRF9,P10412 5 +Membrane protein ectodomain proteolysis 0.3639972044544374 0.3302918647142936 0.7411794393688267 1.0 1.0 9 Q9NZ08 1 +Epidermis development 0.2633042884640099 0.3302539696882063 0.7412080703220483 1.0 1.0 48 P15924,O95487,P43034,P51648,Q15648,P18074,P22392,Q12948,P19447,P21359,O75844,Q9Y251,Q99816 13 +Negative regulation of response to wounding 0.4074983761187628 0.3294230047151621 0.7418359820220526 1.0 1.0 6 Q7Z460,Q05655,Q96G23 3 +Histone phosphorylation 0.3719433031727153 0.3289835752698942 0.7421681027055118 1.0 1.0 22 Q9ULX6,Q8IV63,P20248,P24941,Q05655,Q00535,P50750,Q9Y4B6,O75844 9 +Striated muscle cell development 0.3676071984030533 0.3289350039215027 0.7422048158685979 1.0 1.0 11 Q16527 1 +Positive regulation of alpha beta t cell differentiation 0.4069969635384808 0.3277136350779198 0.743128192935439 1.0 1.0 6 Q13951,P61586 2 +Alcohol catabolic process 0.3698626389877251 0.3259641821782901 0.7444514548128185 1.0 1.0 13 Q06520 1 +Positive regulation of cell projection organization 0.2996104684528419 0.3258603143611855 0.7445300427605979 1.0 1.0 65 P98155,O94813,P42858,Q16625,P16333,Q06787,P43034,Q9UQB8,Q9H2U1,P25054,Q32P28,P60953,Q15334,Q7L576,Q9H4M9,P42345,Q15555,P27695 18 +Positive regulation of protein localization to centrosome 0.7212360289283317 0.3241989978294142 0.7457873807576378 1.0 1.0 2 P25054 1 +Positive regulation of type i interferon production 0.3716383645323152 0.3240169352548125 0.7459252128336356 1.0 1.0 21 O14802,P41440,Q9H2U1,P42224,Q9BUI4,O60828,O00571,Q7Z434 8 +Integrin mediated signaling pathway 0.3720492145313254 0.3222747268134571 0.7472445776850842 1.0 1.0 17 Q05397,Q9P258,Q13418,P60953,P22392 5 +Hippo signaling 0.4437500000000149 0.3214679024947714 0.7478558325496931 1.0 1.0 4 Q01085,Q13043,Q4VCS5 3 +Regulation of histone modification 0.2839618729070949 0.3214628597986397 0.7478596534250124 1.0 1.0 58 Q12824,P26358,P50750,Q6PD62,Q9GZS3,Q96FW1,Q6W2J9,Q9NPI1,Q969T9,O95071,Q96ST2,O75844,Q01105 13 +Regulation of dna topoisomerase atp hydrolyzing activity 0.5228089624571857 0.3212803474969065 0.7479979480495524 1.0 1.0 3 Q96T88 1 +Regulation of isomerase activity 0.5228089624571857 0.3212803474969065 0.7479979480495524 1.0 1.0 3 Q96T88 1 +Response to type i interferon 0.3698525433423017 0.3212744392513689 0.7480024250263184 1.0 1.0 14 P34897,P42224,Q7Z739,Q9Y3Z3,Q7Z434 5 +B cell activation 0.3283370563106322 0.3210263187927442 0.7481904461300806 1.0 1.0 37 Q96QE3,P17812,P78318,Q05655,Q9UQ84,P14174,P78527 7 +Telomere maintenance via semi conservative replication 0.4430921052631744 0.3195346340121122 0.7493211326395943 1.0 1.0 4 P12004,P51530,P39748 3 +Positive regulation of interleukin 8 production 0.3753532719652239 0.3183736628365324 0.7502015137349782 1.0 1.0 8 P62820,P40763,Q7Z434 3 +T cell activation 0.2833237044976964 0.316895566962029 0.7513228458639163 1.0 1.0 58 Q92990,P24390,P62753,P62942,P17812,P40763,P51452,P61586,Q13951,Q5ZPR3,P0CG08,P78527,Q96J02,Q9NUQ9,Q08209,P31749,P42345 17 +Negative regulation of keratinocyte proliferation 0.7176199868507511 0.3161827345432522 0.7518638118839558 1.0 1.0 2 Q15648 1 +Response to temperature stimulus 0.2951831596154248 0.3161806016992932 0.7518654306748433 1.0 1.0 43 P17612,O60884,Q13217,Q9H2U1,P49770,P42345,P21359,Q14011,P31749,Q99543,P31689 11 +Sulfur compound biosynthetic process 0.3316459730022993 0.3144692334727023 0.7531646802120677 1.0 1.0 36 Q8WUX2,O43252,Q13126,O00763,Q9NZ01,Q13085 6 +Magnesium ion homeostasis 0.7166337935568705 0.3140155133892232 0.7535092563088839 1.0 1.0 2 Q12955 1 +Negative regulation of immune system process 0.3120553451240448 0.3139014328582823 0.7535959020874028 1.0 1.0 40 Q92990,P25786,P28070,Q9NRX4,Q7Z739,Q13951,Q9Y3Z3,P14174,P21359,Q96J02,P31749 11 +Trna aminoacylation for mitochondrial protein translation 0.3884703966912697 0.3137742816256156 0.7536924789053752 1.0 1.0 7 Q9NP81,Q5JPH6,Q9Y2Z4 3 +Histone h4 acetylation 0.366082163781517 0.3134326692022782 0.7539519672799853 1.0 1.0 24 Q86UY6,Q96ST2,O75844,Q12824 4 +Progesterone receptor signaling pathway 0.5196415319595251 0.3132061650782567 0.7541240348535472 1.0 1.0 3 O95071 1 +Polyketide metabolic process 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 P14550,O43488 2 +Tertiary alcohol metabolic process 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 O43488,P14550 2 +Aminoglycoside antibiotic metabolic process 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 P14550,O43488 2 +Calcium ion transport into cytosol 0.3663998847652193 0.3118886482390592 0.7551251498986635 1.0 1.0 13 P17612,P62942,P27695,P42858 4 +Lamellipodium assembly 0.3696099589720262 0.3115611137898265 0.7553740908389279 1.0 1.0 19 O94813,Q16625,P16333,P60953,Q7L576,P42345 6 +Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.7153188691650196 0.311138648562568 0.7556952209615608 1.0 1.0 2 P16333 1 +Inner ear auditory receptor cell differentiation 0.4210901652125424 0.31105075598525 0.7557620363918807 1.0 1.0 5 O95487 1 +Response to cold 0.3629248436606367 0.3101063018936517 0.7564801201249902 1.0 1.0 11 P17612,Q13217 2 +Regulation of viral transcription 0.439626896018333 0.3094418356784744 0.7569854506288349 1.0 1.0 4 Q4G0J3 1 +Regulation of sister chromatid cohesion 0.3606948684823042 0.3087054551088887 0.7575455938096707 1.0 1.0 10 Q7Z5K2,Q8IY18 2 +Neurotrophin trk receptor signaling pathway 0.3867272381418671 0.3076226739606466 0.7583694650081805 1.0 1.0 7 Q96F07,Q7L576,P27695 3 +Methylation 0.3704152801426753 0.3067037127649651 0.7590689035280955 1.0 1.0 101 Q9H7B4,Q8NB78,Q9NRG4,O60678,Q86X55,Q9BV86,Q96ST2,Q99873,Q9H993,P26358,P57081,Q9GZS3,Q9NNW5,Q4G0J3,O14744,O60725,Q12824,Q8N1G2,Q6P2P2,Q6W2J9,Q8WTS6,P10412,O75844,Q96P11,Q6PD62,O94776 26 +Regulation of lamellipodium assembly 0.3670855015341739 0.3062677915603778 0.7594007602733615 1.0 1.0 15 O94813,Q16625,P60953,Q7L576,P42345 5 +Response to heat 0.338094121264642 0.305174373771898 0.7602333488106445 1.0 1.0 34 P17612,Q96EB6,O60884,Q13144,Q9NR50,Q9UHD1,Q9UI10,Q9H2U1,P49770,Q99543,P42345,P21359,Q99615,P09601,P31749,O75340,P31689 17 +Cellular response to arsenic containing substance 0.3715209275963365 0.304061901446374 0.7610807316893535 1.0 1.0 8 P09601,Q96QD8,Q9H2U1,O00571 4 +Chondrocyte development 0.7120315581854038 0.3040106505137024 0.7611197770254507 1.0 1.0 2 P50454 1 +Somatic diversification of immunoglobulins 0.3674980988521441 0.3038770521130613 0.7612215613392763 1.0 1.0 20 Q96QE3,Q9UQ84,P78527 3 +Virion assembly 0.3671071473234305 0.3035773794442041 0.7614498873109699 1.0 1.0 16 P62820,P11498,Q9H9H4,Q96EY5 4 +Negative regulation of cellular response to insulin stimulus 0.3712489193666307 0.3030547361736334 0.7618481482713868 1.0 1.0 8 P49815,Q05655 2 +Bone cell development 0.398780711385522 0.3001949077251178 0.7640284891065181 1.0 1.0 6 Q8IZP0,P43034,Q15648 3 +Regulation of establishment of protein localization to mitochondrion 0.3666873104153536 0.2991729187672945 0.7648081112337581 1.0 1.0 18 O95376,P55786 2 +Regulation of developmental growth 0.2731682812423365 0.2990844718016944 0.7648755940352376 1.0 1.0 46 Q8N0X7,Q96PU5,P11802,Q7L576,Q12948,O00763,O75844 7 +Oligosaccharide lipid intermediate biosynthetic process 0.4164454498955852 0.2967397148135542 0.7666652338837774 1.0 1.0 5 Q9H553,Q9BV10 2 +Protein k63 linked deubiquitination 0.3610232289540393 0.2960461100989865 0.767194868027055 1.0 1.0 12 P34897 1 +Alpha beta t cell proliferation 0.7077580539118931 0.2948824386317008 0.7680836876987926 1.0 1.0 2 Q96J02 1 +Spliceosomal tri snrnp complex assembly 0.3589540122366951 0.2944251584923404 0.7684330447289724 1.0 1.0 11 O95400 1 +Positive regulation of nucleocytoplasmic transport 0.3629991750097607 0.2943986475162244 0.7684533002683025 1.0 1.0 23 P17612,O00410,P62826,Q13148,Q92688,Q05655,Q7Z434,O95071,Q07666,P14923 10 +Dicarboxylic acid catabolic process 0.3969183637583056 0.2940892431212191 0.7686897103749659 1.0 1.0 6 Q9NRN7 1 +Multicellular organismal response to stress 0.3826732577353824 0.2934904897375133 0.7691472677061331 1.0 1.0 7 P31749,P42345 2 +Regulation of mitochondrial fission 0.3546579007602064 0.293387586242854 0.7692259129390577 1.0 1.0 9 Q9NUQ9 1 +Establishment or maintenance of bipolar cell polarity 0.3621811304845434 0.2903297019344086 0.7715640180770365 1.0 1.0 14 Q14168,P57105,P61586,Q13418 4 +Auditory receptor cell development 0.4325907754767325 0.2894227730069656 0.772257870011233 1.0 1.0 4 O95487 1 +Monoubiquitinated protein deubiquitination 0.3811671965064943 0.2883035649947905 0.7731143784895267 1.0 1.0 7 Q99496,Q9Y6J9,Q96K76,Q9Y4A5 4 +Entry of bacterium into host cell 0.4135981215783912 0.2881122493128769 0.77326081641118 1.0 1.0 5 P06756,P22681,Q9UPT5 3 +Establishment of protein localization to plasma membrane 0.3622152876083873 0.2868641470471816 0.7742163437210261 1.0 1.0 22 Q9HD26,P61026,Q4J6C6 3 +Regulation of calcium ion transport 0.3526342934095866 0.2863761130661585 0.7745900679334414 1.0 1.0 28 P17612,P42858,Q06787,O76024,P61586,Q00535,P62942,Q13555,P27695 9 +Telencephalon glial cell migration 0.3664610619618732 0.2855186626138697 0.7752468084974153 1.0 1.0 8 P07942,P43034 2 +Cerebral cortex radially oriented cell migration 0.3664610619618732 0.2855186626138697 0.7752468084974153 1.0 1.0 8 P07942,P43034 2 +Positive regulation of lamellipodium assembly 0.3582886280906092 0.2853288650195246 0.7753922004904308 1.0 1.0 12 Q16625,P60953,Q7L576,P42345 4 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.3564475741882225 0.2846666984132663 0.7758995062805647 1.0 1.0 11 Q08554,Q14574 2 +Vesicle docking 0.3616436908877011 0.2844208241482751 0.7760879023231138 1.0 1.0 15 Q7Z6M1,O60499 2 +Golgi organization 0.2635311721052573 0.284241389967678 0.7762253983492244 1.0 1.0 51 Q7Z460,O14744,P48729,P42858,Q12907,Q7RTS9,Q6DD88,O15260,P60953,P62820,Q7Z3D4,Q92538,Q7Z392,Q9H4A5 14 +Negative regulation of macroautophagy 0.357964664787343 0.2840680136000931 0.776358259083054 1.0 1.0 12 P49815,P42345 2 +Regulation of mitochondrial mrna stability 0.7024983563445081 0.2838646412423849 0.7765141145028698 1.0 1.0 2 Q969Z0 1 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3576566620511165 0.2828671912659378 0.7772786454360787 1.0 1.0 25 Q96QE3,P61978,Q96RU2,Q96K76,P14174,P78527 6 +Visual behavior 0.3931387057409693 0.2818521976924025 0.7780568447424943 1.0 1.0 6 P21359,Q00535 2 +Positive regulation of cation channel activity 0.3786841845125123 0.2798281743000135 0.7796093348983182 1.0 1.0 7 Q00535,P27695,P42858 3 +Histone h3 acetylation 0.3604584833640863 0.2797357940738734 0.7796802144953188 1.0 1.0 15 Q969T9,Q12824,Q9NRF9,Q9Y6J9,Q9Y4A5 5 +Positive regulation of cell morphogenesis involved in differentiation 0.3593808297991228 0.2789434529230947 0.780288220863329 1.0 1.0 23 Q07021,Q9H2U1,Q9UQB8,P43034,Q13418,P78527 6 +Sperm dna condensation 0.6998685075608159 0.2784464371855776 0.7806696766277481 1.0 1.0 2 Q14997 1 +Negative regulation of peptide secretion 0.4099436071382957 0.2772045626496481 0.7816230363767196 1.0 1.0 5 Q16836 1 +Negative regulation of hormone secretion 0.4099436071382957 0.2772045626496481 0.7816230363767196 1.0 1.0 5 Q16836 1 +Lipid import into cell 0.3778311196978597 0.2769384979479292 0.781827331135492 1.0 1.0 7 P31751 1 +Mitochondrial electron transport ubiquinol to cytochrome c 0.4278064566616003 0.2761829891434609 0.7824075220071283 1.0 1.0 4 Q9UDW1 1 +Rna stabilization 0.3561131792879854 0.2761786564235596 0.7824108496567033 1.0 1.0 25 O60506,Q92804,Q14011,P35637 4 +Double strand break repair via break induced replication 0.3494120293082114 0.2732950374986932 0.7846264296915324 1.0 1.0 9 P33991,P33993,Q9BRT9,Q9Y248 4 +Regulation of macroautophagy 0.2662751047535571 0.2731917030211719 0.7847058575174153 1.0 1.0 53 P17612,Q96A65,P68402,P42858,P07384,O15270,P27544,Q00535,Q13137,Q9UPT5,Q93050,P49815,Q9Y487,P31749,P42345 15 +Positive regulation of production of mirnas involved in gene silencing by mirna 0.4085453609725037 0.2730811343872294 0.7847908483454391 1.0 1.0 5 Q13546 1 +Golgi localization 0.4263817542002249 0.2722998667850417 0.7853914586429986 1.0 1.0 4 P60953 1 +Protein retention in er lumen 0.4259543146557236 0.271140230092723 0.7862831809257234 1.0 1.0 4 O43731 1 +Maintenance of protein localization in endoplasmic reticulum 0.4259543146557236 0.271140230092723 0.7862831809257234 1.0 1.0 4 O43731 1 +Regulation of maintenance of sister chromatid cohesion 0.4259275997642459 0.2710678356734845 0.78633885915217 1.0 1.0 4 Q8IY18 1 +Heart process 0.3511794333224913 0.2702167983883044 0.7869934699966405 1.0 1.0 27 P17612,P15924,Q96PU5,O75844,P14923,P42345 6 +Regulation of osteoblast proliferation 0.3893431313829568 0.2697760680604009 0.7873325353223168 1.0 1.0 6 P61586,Q9Y251,P20248 3 +Osteoblast proliferation 0.3893431313829568 0.2697760680604009 0.7873325353223168 1.0 1.0 6 P61586,Q9Y251,P20248 3 +Microtubule anchoring 0.3619020020384471 0.2691665774071168 0.7878014987799244 1.0 1.0 8 O75381,O95684,Q15154 3 +Protein k11 linked ubiquitination 0.3753704313467224 0.2686673939597976 0.788185645331005 1.0 1.0 7 Q9UJX3,P30260,Q9UJX4,Q9H1A4,P68036,Q9UJX2 6 +Rna mediated gene silencing by inhibition of translation 0.3889820563696494 0.2686385295598335 0.7882078595025039 1.0 1.0 6 Q9BWF3 1 +Regulation of ryanodine sensitive calcium release channel activity 0.4068475588754269 0.2681119145881204 0.7886131749652561 1.0 1.0 5 P17612 1 +Regulation of epidermis development 0.3480343328457688 0.268097572410985 0.7886242143931335 1.0 1.0 9 Q15648,P22392,Q12948 3 +Protein k63 linked ubiquitination 0.3564271620010341 0.267822270177535 0.7888361276255025 1.0 1.0 14 O95376,Q96FW1,O00571,O95071 4 +Energy homeostasis 0.3749418470981625 0.2672366321139491 0.7892869730721002 1.0 1.0 7 P40763,Q96EB6,O00763 3 +Regulation of extent of cell growth 0.3581878373296984 0.2672080480200306 0.789308979952815 1.0 1.0 21 Q8N0X7,Q96ST3,P43034,Q00535,Q7L576 5 +Skeletal muscle tissue regeneration 0.4240300243453243 0.2659505771511559 0.7902772723036495 1.0 1.0 4 Q7Z4V5 1 +Positive regulation of alpha beta t cell activation 0.3608686791225836 0.2655084708796107 0.7906177851444083 1.0 1.0 8 Q13951,P61586,O14617 3 +Regulation of atp metabolic process 0.3549741815885626 0.2653132288918154 0.7907681743952537 1.0 1.0 24 P34897,P61586,O75746,Q9BSK2,P36404 5 +Necroptotic signaling pathway 0.6932938856015727 0.2651684994249382 0.7908796603417549 1.0 1.0 2 Q13546 1 +Regulation of alpha beta t cell differentiation 0.3736610795064777 0.2629785383739038 0.7925671209639935 1.0 1.0 7 Q13951,P61586 2 +Regulation of lymphocyte differentiation 0.3558945564061976 0.2619467404038919 0.793362503716827 1.0 1.0 15 Q13951,P12956,P78527 3 +Mature ribosome assembly 0.4045048827810455 0.261323580707733 0.79384298341388 1.0 1.0 5 Q07021 1 +Ribonucleoprotein complex localization 0.3864347046382722 0.2606696728200265 0.7943472552642015 1.0 1.0 6 Q96ST2 1 +Interferon gamma mediated signaling pathway 0.4041204890901585 0.2602173539477402 0.7946961187293586 1.0 1.0 5 Q15648 1 +Changes to dna methylation involved in embryo development 0.6903353057199366 0.2593192567237658 0.7953889227491433 1.0 1.0 2 P26358 1 +Genomic imprinting 0.6903353057199288 0.2593192567237503 0.7953889227491553 1.0 1.0 2 Q6PD62 1 +Regulation of genetic imprinting 0.6903353057199288 0.2593192567237503 0.7953889227491553 1.0 1.0 2 Q6PD62 1 +Protein k48 linked deubiquitination 0.3514702632835431 0.2591955857014999 0.7954843368557323 1.0 1.0 12 Q93008,Q6GQQ9,Q93009,Q96FW1,Q99496 5 +Epiboly 0.3589527951398299 0.2587738937445141 0.7958097017097738 1.0 1.0 8 P61586,P20248,P42345 3 +Morphogenesis of an epithelial sheet 0.3589527951398299 0.2587738937445141 0.7958097017097738 1.0 1.0 8 P61586,P20248,P42345 3 +Regulated exocytosis 0.3355258274470599 0.258288145136357 0.7961845347561156 1.0 1.0 32 P22681,Q9NVJ2,Q9BRK5,P61026,Q7L0J3,Q4J6C6,Q68EM7 7 +Positive regulation of lipid storage 0.3855613294498383 0.2579604011375945 0.796437468452575 1.0 1.0 6 Q8WTV0,O00763 2 +Dendrite extension 0.385407258740745 0.2574836845454517 0.7968054086730803 1.0 1.0 6 Q96PU5,Q7L576 2 +Positive regulation of smooth muscle contraction 0.689020381328066 0.2567448515975733 0.7973757452067205 1.0 1.0 2 P61586 1 +Positive regulation of chromosome segregation 0.3850028201946955 0.2562340423427751 0.7977701238460047 1.0 1.0 6 Q8IY18 1 +Spindle elongation 0.3846829880907451 0.2552476142686383 0.7985318577874334 1.0 1.0 6 O43663,Q02241 2 +Positive regulation of response to cytokine stimulus 0.3485008089819325 0.2544703364448892 0.7991322180551039 1.0 1.0 11 Q15648,Q99829,P43034,Q7Z434 4 +Positive regulation of establishment of protein localization to mitochondrion 0.3515092075827119 0.2537854316239381 0.799661328938555 1.0 1.0 13 P55786 1 +Regulation of anatomical structure size 0.3400534305882768 0.2530257340445257 0.8002483272025525 1.0 1.0 90 Q8N0X7,O95429,Q9UQB8,P43034,P61586,Q12948,Q9NUQ9,P35080,Q9P2J5,Q00535,O15511,Q96CW1,Q7L576,Q96J84,Q96F07,Q96ST3,O94813,Q05655,Q13045,Q9HB40,P42345 21 +Negative regulation of ion transmembrane transport 0.3541085144159362 0.2521310029242861 0.8009398070094806 1.0 1.0 16 Q9HD26 1 +Macropinocytosis 0.4939164748437868 0.2516822942352059 0.8012866437002943 1.0 1.0 3 Q06481,Q9BZG1 2 +Hematopoietic progenitor cell differentiation 0.3501048825694194 0.2506934377096646 0.8020511346507133 1.0 1.0 25 Q96ST3,O43809,Q9H2U1,P18074,Q12948,P78527,Q96J02,Q9Y520,Q9NPH0 9 +Telomere maintenance 0.2820727779074773 0.2502606898316675 0.802385754313145 1.0 1.0 62 Q9UPR3,P41440,Q9H2U1,P12956,P22626,Q9UQ84,P18887,P78527,Q8IY18 9 +Negative regulation by host of viral transcription 0.4178783682795208 0.2497035908446179 0.8028165810638443 1.0 1.0 4 Q13148 1 +Negative regulation of leukocyte migration 0.4003651510983179 0.2495243356182317 0.8029552189941578 1.0 1.0 5 P31749,P14174 2 +Snrna modification 0.4003413649322334 0.2494572716110703 0.8030070886166696 1.0 1.0 5 Q4G0J3,Q9NPE3 2 +Regulation of cytosolic calcium ion concentration 0.3534859761759898 0.2482695678969272 0.8039258433122236 1.0 1.0 21 P17612,P42858,P06756,Q00535,Q15334,P62942,P27695 7 +Hindbrain development 0.3299545160127429 0.2476655379900911 0.8043931979619778 1.0 1.0 33 O95487,Q9BRK5,O95456,Q12948,P18887 5 +Postsynaptic modulation of chemical synaptic transmission 0.3996621623989851 0.2475458489570059 0.8044858129832664 1.0 1.0 5 Q7L576 1 +Protein o linked glycosylation via serine 0.4916334810132743 0.2465839729235095 0.8052302093582957 1.0 1.0 3 Q10471 1 +Response to arsenic containing substance 0.3480696787260239 0.2464867326243196 0.8053054735163749 1.0 1.0 12 Q9H2U1,O00571,Q9BWF3 3 +Response to radiation 0.3248265797639426 0.245924098976432 0.8057409883181346 1.0 1.0 83 P22681,P19447,Q15046,Q9H2U1,Q9BRK5,Q96K76,Q92547,Q9BWF3,Q96KB5,P31751,P78527,P21359,Q86UE8,P27544,P18074,O75844,P31749,Q96RU2,Q15555,Q05655,P12956,P52701,Q9UNS2,Q14011 24 +Multicellular organismal signaling 0.3522470188397798 0.2458423062406952 0.8058043062015032 1.0 1.0 22 P17612,P15924,O75844,P14923 4 +Negative regulation of defense response 0.3501043685213558 0.2451299799505862 0.8063557902879963 1.0 1.0 24 P25786,Q14166,P28070,Q07021,Q05655,Q9NX58,Q7Z739,Q92890,Q96KB5,P19474,Q9Y3Z3,Q96J02,P04439 13 +Positive regulation of hemopoiesis 0.3504428186784829 0.2450863542744167 0.8063895684844997 1.0 1.0 14 P61586,Q13951,P12956,Q13546,P78527 5 +Adipose tissue development 0.3491705065849352 0.2450376818820092 0.806427254644912 1.0 1.0 13 O15270,P11802,Q8N0X7,P43490 4 +Vitamin metabolic process 0.3432008243181003 0.2446654469088505 0.806715484364825 1.0 1.0 28 P41440,P34897,Q96RQ3,O14678,P50747,Q9NRN7 6 +Positive regulation of behavior 0.4906691119376873 0.2444486216517733 0.8068833890278313 1.0 1.0 3 Q9Y6A4 1 +Ensheathment of neurons 0.3506664357185937 0.2429549786321836 0.8080402744250901 1.0 1.0 23 Q96P11,Q96PU8,O75746,P18074,P31751,Q7L576,Q9UPY3,P21359,P31749,P42345,P49770 11 +Mitochondrial transport 0.3079604312632212 0.2425514944454735 0.8083528609687911 1.0 1.0 75 O95376,O95831,O43772,O60830,P55786,Q14849 6 +Regulation of phosphatase activity 0.3522137647590012 0.241734323652305 0.8089860317290076 1.0 1.0 20 Q8IV63,O95429,P42858,P42345,Q9UPN7 5 +Regulation of carbohydrate biosynthetic process 0.3519247608794704 0.2416901504101982 0.8090202621745324 1.0 1.0 17 Q00610,Q96EB6,Q9BYT8,Q16531,Q93009,P31751,O15294,P31749 8 +Positive regulation of actin nucleation 0.6811308349770016 0.2416273522241978 0.8090689259712074 1.0 1.0 2 Q7L576 1 +Positive regulation of arp2 3 complex mediated actin nucleation 0.6811308349770016 0.2416273522241978 0.8090689259712074 1.0 1.0 2 Q7L576 1 +Regulation of ion transmembrane transport 0.2657746866947998 0.2411228903701616 0.8094598721452795 1.0 1.0 55 P42858,Q13642,Q9BSH4,P27695,P17612,P07384,Q06787,Q9HD26,Q96PU5,Q00535,P46939,Q15334,O75844,P0CG08,O43865,Q13546,O43707,P62942,Q8N335 19 +Regulation of cellular component size 0.3199470648801492 0.2408966640169676 0.8096352077449465 1.0 1.0 81 Q8N0X7,O95429,Q9UQB8,P43034,P61586,Q9NUQ9,P35080,Q9P2J5,Q00535,O15511,Q96CW1,Q7L576,Q96J84,Q96F07,Q96ST3,O94813,Q05655,Q13045,P42345 19 +Response to steroid hormone 0.2931867388843064 0.2408225234305701 0.8096926721137194 1.0 1.0 68 Q9H7B4 1 +Cellular response to radiation 0.276754671342643 0.2407074195457399 0.8097818880630743 1.0 1.0 44 Q86UE8,Q96RU2,Q9H2U1,Q96K76,Q05655,Q15555,Q96KB5,P31751,P12956,O75844 10 +Positive regulation of transcription of nucleolar large rrna by rna polymerase i 0.353634949737735 0.240413502439623 0.8100097116873537 1.0 1.0 8 Q12824 1 +Response to uv 0.298648664960683 0.2390714657164064 0.8110501673454711 1.0 1.0 40 Q96RU2,Q9H2U1,Q96K76,Q9BRK5,Q05655,Q96KB5,P18074,P19447,P52701,Q14011,P31749 11 +Protein kinase b signaling 0.3370159811366713 0.2387210680952807 0.8113218790241876 1.0 1.0 30 Q05397,O95429,Q99829,Q9Y251,Q86UE4,P49815,P31749,P42345 8 +Lipid localization 0.3113953395503052 0.2384603966275536 0.8115240283671834 1.0 1.0 77 P98155,O43772,Q9H6V9,P22059,P35790,Q9NVJ2,Q99720,P31751,O43808,Q14534,Q14849,P23786,O00763,O14678,P14174,P31749,Q00169,Q8WTV0,Q05655 19 +Action potential 0.3511423730047964 0.2375695077482238 0.8122150027583652 1.0 1.0 20 P14923,P15924,Q96PU5,P42345 4 +Cell activation involved in immune response 0.3077271981199727 0.2363045134059796 0.8131963849126458 1.0 1.0 38 Q96QE3,P22681,Q15046,Q9UQ84,Q92538,P42345 6 +Regulation of dna replication 0.2562492459478063 0.2349781218440633 0.8142257140906468 1.0 1.0 51 Q7Z5K2,Q96QE3,P30153,P24941,Q9Y248,P20248,P40937,Q9BRT9,Q14691,Q9UBD5,O43913,Q9NRF9,O75844 13 +Defense response to symbiont 0.2648044824500815 0.2348502205746964 0.8143249872212164 1.0 1.0 55 O14802,Q96ST3,Q13217,Q07021,Q9H2U1,P42224,Q92890,Q9BUI4,O95801,O60828,Q9Y3Z3,Q7Z434,Q96J02,O75844,Q9HCE1 15 +Negative regulation of smooth muscle cell differentiation 0.4120667730480667 0.2348445227570148 0.8143294097658615 1.0 1.0 4 P26358 1 +Glucose metabolic process 0.2603811072307876 0.2339199207396182 0.8150471476899768 1.0 1.0 53 P11498,Q9BYT8,O75844,P31751,O00763,Q9BRR6,P31749 7 +Regulation of clathrin dependent endocytosis 0.4853666557053538 0.2329028270908093 0.815836863105514 1.0 1.0 3 Q8IYB5,P50570 2 +Regulation of transcription from rna polymerase ii promoter in response to oxidative stress 0.6755424063116358 0.2312631899427545 0.8171103417499685 1.0 1.0 2 Q96ST3 1 +Negative regulation of ion transport 0.3489737432239144 0.2305668500599767 0.81765132354812 1.0 1.0 17 Q9HD26 1 +Negative regulation of vascular associated smooth muscle cell proliferation 0.392919800327337 0.2289484403083846 0.8189089903860962 1.0 1.0 5 P61586 1 +Cytoplasmic sequestering of protein 0.3412369656441257 0.2279033738311279 0.8197213598030466 1.0 1.0 11 Q7L5D6,Q9HD26,Q14145 3 +Regulation of stress activated protein kinase signaling cascade 0.3343595616097045 0.2271913342106974 0.8202749658264663 1.0 1.0 30 Q53EL6,P78318,P51452,P43034,Q96KB5,P60953,Q96J02,Q99873,O75844,P31689 10 +Insulin metabolic process 0.4824071029266535 0.2266032881862899 0.8207322352001662 1.0 1.0 3 Q96HE7,P14735 2 +Negative regulation of transferase activity 0.2864301857743079 0.2248170226933808 0.8221216228462613 1.0 1.0 66 Q9H7B4,Q53EL6,O95684,P25054,P27544,P22681,P51452,Q05655,P61927,Q9NRX4,P21359,P49815,P31749,Q99816,P31689 15 +Axonal fasciculation 0.4814205853337604 0.224526650703275 0.8223475319567521 1.0 1.0 3 Q9NQC3,P42574 2 +Neurotransmitter catabolic process 0.6712689020381297 0.2235319113516741 0.8231215496969411 1.0 1.0 2 P21964 1 +Negative regulation of dendrite development 0.6706114398422155 0.2223574964972356 0.8240355964557258 1.0 1.0 2 Q86X55 1 +Maintenance of postsynaptic specialization structure 0.6706114398422096 0.222357496497225 0.824035596455734 1.0 1.0 2 Q15334 1 +Intraciliary transport 0.4065749551904172 0.221249889361026 0.8248978655479307 1.0 1.0 4 A0AVF1 1 +Dendrite self avoidance 0.6699539776462824 0.2211870940494215 0.8249467578641385 1.0 1.0 2 P35613 1 +Positive regulation of endocytosis 0.3464705574360937 0.2209558114025942 0.8251268399705338 1.0 1.0 21 P61978,P41440,P22681,Q96PU5,Q96CW1,Q08209,Q99816 7 +Regulation of cell shape 0.3372301635612104 0.2195279888278463 0.8262387796264241 1.0 1.0 28 Q05397,O75844,Q9UQB8 3 +Circulatory system process 0.2917759482187395 0.2193975925228941 0.8263403452372038 1.0 1.0 69 P17612,P41440,Q16625,P15924,Q96PU5,Q9NZ08,Q12948,Q9UIQ6,O75844,P14923 10 +Endodermal cell differentiation 0.3599597990330176 0.2191254667092673 0.826552313242461 1.0 1.0 7 P07942,Q6PD62 2 +Endoderm formation 0.3599597990330176 0.2191254667092673 0.826552313242461 1.0 1.0 7 P07942,Q6PD62 2 +Regulation of hematopoietic stem cell differentiation 0.3599492717517801 0.2190930025500503 0.8265776015188993 1.0 1.0 7 Q12948,P78527 2 +Chemical synaptic transmission postsynaptic 0.3418628357339914 0.2184057705218574 0.827112969838538 1.0 1.0 13 Q9UQB8,Q15334,Q14168,Q08209,P31749 5 +Regulation of postsynaptic membrane potential 0.3418628357339914 0.2184057705218574 0.827112969838538 1.0 1.0 13 Q9UQB8,Q15334,Q14168,Q08209,P31749 5 +Positive regulation of calcium ion transmembrane transporter activity 0.3590618201464528 0.2163632435306771 0.8287046150926072 1.0 1.0 7 Q00535,P42858 2 +Nucleobase biosynthetic process 0.3436376854058329 0.2162416725112645 0.8287993719186488 1.0 1.0 15 P34897,P34896,P17812,P42345 4 +Positive regulation of binding 0.2597272783485962 0.2161821871523034 0.828845737855141 1.0 1.0 54 P50750,Q96D46,P41440 3 +Aggrephagy 0.4043402913137612 0.215844309886575 0.8291091080141741 1.0 1.0 4 Q13501,P42858 2 +Positive regulation of chromatin organization 0.3462413587817582 0.2157253461381517 0.8292018430094497 1.0 1.0 8 P26358,Q96ST3 2 +Regulation of keratinocyte differentiation 0.3457956782976454 0.2142692150189596 0.8303371233856023 1.0 1.0 8 P22392,Q12948 2 +O glycan processing 0.3872844815064919 0.2139400442623959 0.830593812294345 1.0 1.0 5 Q10471 1 +Leptin mediated signaling pathway 0.4761082495879451 0.213544920933619 0.8309019552008834 1.0 1.0 3 P40763 1 +Regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.3389170092491829 0.2134065947342849 0.8310098371274093 1.0 1.0 12 P21359,P31749,P30153,P30154 4 +Cellular response to heat 0.3421128665094943 0.2132876635359362 0.8311025952533444 1.0 1.0 24 P17612,P21359,Q99543 3 +Positive regulation of receptor recycling 0.4031913638630257 0.2130937648876275 0.8312538278605621 1.0 1.0 4 P07355,Q14160 2 +Regulation of stem cell proliferation 0.3703094140882185 0.2125983479754485 0.8316402601140549 1.0 1.0 6 P26583,Q96AC1,P19525,Q00839,O95251 5 +Regulation of gtpase activity 0.2545625532805573 0.2105762721590582 0.8332179292152315 1.0 1.0 52 Q05397,P31751,P21359,Q15555,P49815,P42345,Q4KMP7 7 +Response to leptin 0.3859442044486376 0.210443614165647 0.8333214555235182 1.0 1.0 5 P40763,P20248 2 +Regulation of dephosphorylation 0.3067619768711058 0.210206922393895 0.8335061769780843 1.0 1.0 37 Q9UPR3,O95429,Q8IV63,P42858,P78318,Q05655,Q13526,P42345,Q9UPN7 9 +Regulation of erbb signaling pathway 0.3407691563219214 0.2098616452583585 0.8337756582317888 1.0 1.0 14 P22681,P51452,Q96EY5,Q99816 4 +Regulation of protein localization to centrosome 0.4740360620082225 0.2093536250499017 0.8341721923889023 1.0 1.0 3 P25054 1 +Negative regulation of coagulation 0.6630506245890881 0.2091408343584581 0.8343382982756997 1.0 1.0 2 Q05655 1 +Reactive oxygen species metabolic process 0.2821410327159303 0.2071032867979162 0.8359291952536985 1.0 1.0 42 Q15067,P20248,P00374,A1X283,P28331,P61586,Q05655,Q13546,Q15120,P39210,Q9BSK2,Q92538 12 +Immune response regulating cell surface receptor signaling pathway 0.3238005118012863 0.2058978304676781 0.8368707201778545 1.0 1.0 32 Q05397,Q5ZPR3 2 +Post golgi vesicle mediated transport 0.2920342848054965 0.2050431810771657 0.837538388061075 1.0 1.0 40 Q96A65,Q9HD26,Q92572,O43795,P61026,Q15276,Q92538,Q4J6C6,Q9H4A5 9 +Motor neuron axon guidance 0.3838212923804032 0.2049636253949108 0.8376005443891179 1.0 1.0 5 Q00535 1 +Toxin transport 0.3362727563883625 0.2041658550530913 0.8382238930554669 1.0 1.0 12 Q93050 1 +Organic hydroxy compound catabolic process 0.3402225191616895 0.2040695294429365 0.8382991652538814 1.0 1.0 15 Q06520 1 +Lamellipodium organization 0.3349115801638991 0.2023102639789484 0.8396741763879447 1.0 1.0 27 O94813,Q16625,P16333,O15511,P60953,Q7L576,P42345 7 +Positive regulation of dephosphorylation 0.3394480372690795 0.2013444948881015 0.8404292129946525 1.0 1.0 15 Q13526,Q8IV63,P42345 3 +Positive regulation of protein dephosphorylation 0.3394480372690795 0.2013444948881015 0.8404292129946525 1.0 1.0 15 Q13526,Q8IV63,P42345 3 +Lung alveolus development 0.469582374218999 0.200522087288117 0.8410722856180319 1.0 1.0 3 Q04656,Q16706 2 +Transcription elongation from rna polymerase i promoter 0.3971942155731796 0.1990554551005653 0.8422193655553674 1.0 1.0 4 P18074 1 +Renal tubule development 0.3652845910092759 0.1984906100739154 0.8426612306765231 1.0 1.0 6 Q9BRK4,Q13418 2 +Transcription elongation from rna polymerase ii promoter 0.3382474323270043 0.1984775679118859 0.8426714338421031 1.0 1.0 24 Q14241,P50750,Q6PD62,Q9GZS3,P19447 5 +Cellular response to peptide 0.3045077909857978 0.197911457345767 0.8431143398198782 1.0 1.0 77 Q05397,P11802,Q9UQB8,O14654,Q92572,P31751,P61026,Q7L576,P78527,P49815,Q9BSK2,P43490 12 +Trna methylation 0.3344552733509018 0.197899003599701 0.8431240837727441 1.0 1.0 12 Q13395,P57081,Q9NNW5 3 +Maintenance of centrosome location 0.6561472715318837 0.197540213123934 0.8434048158367511 1.0 1.0 2 P43034 1 +Maintenance of organelle location 0.6561472715318837 0.197540213123934 0.8434048158367511 1.0 1.0 2 P43034 1 +Regulation of ion transport 0.2962669155402193 0.1974081935841818 0.8435081182312825 1.0 1.0 73 P42858,Q13642,Q9BSH4,P27695,P17612,P07384,Q06787,P61586,Q7L0J3,Q9HD26,O76024,Q96PU5,P11171,Q00535,P46939,Q15334,P14174,O75844,P0CG08,P31749,O43865,Q13546,O43707,P62942,Q8N335,Q13555 26 +Positive regulation of filopodium assembly 0.3643881611079488 0.1960188122691893 0.8445954415658896 1.0 1.0 6 P60953 1 +Negative regulation of actin filament polymerization 0.3398299780487519 0.1958109282662345 0.8447581561378308 1.0 1.0 18 Q9NUQ9,Q05655,P35080,Q13045 4 +Protein processing 0.2565801537609347 0.1951360729724909 0.8452864232091057 1.0 1.0 46 P17612,Q5TDH0,Q15392,Q99829,Q9H9S5,O75787,O75844 7 +Regulation of intracellular protein transport 0.278963392722114 0.1927319891172301 0.8471688694236963 1.0 1.0 65 P17612,Q9Y282,O95376,O95429,P31751,Q7Z434,P21359,P55786 8 +Regulation of hemopoiesis 0.2682433157210153 0.192718977997031 0.8471790597766418 1.0 1.0 44 P40763,P42224,P61586,O95628,Q6PD62,Q9GZS3,Q13951,Q15648,P12956,P78527,P21359,Q99873,P42345 13 +Protein localization to cell cell junction 0.338908164160957 0.1922430737357509 0.8475518071354196 1.0 1.0 8 P15924 1 +Intracellular mrna localization 0.6528599605522785 0.19217338161588 0.8476063956715287 1.0 1.0 2 Q9H2U1 1 +Spindle midzone assembly 0.3627784469597437 0.1916147949642491 0.848043952557046 1.0 1.0 6 O43663,Q02241 2 +Positive regulation of dna damage response signal transduction by p53 class mediator 0.4637891870397004 0.1893975428402174 0.8497812501475284 1.0 1.0 3 O43324 1 +Mitochondrial adp transmembrane transport 0.463763857895957 0.1893498096983764 0.849818658851609 1.0 1.0 3 P12236 1 +Adaptive immune response 0.2676145490706975 0.1893392068131589 0.8498269684321431 1.0 1.0 44 Q96QE3,Q9NZ08,Q6GQQ9,Q96FW1,Q9UQ84 5 +Respiratory chain complex iv assembly 0.3377926005066464 0.1887611121377644 0.8502800518736233 1.0 1.0 8 Q9BSH4,Q7KZN9 2 +Sensory system development 0.2836188700657811 0.1879844736630159 0.8508888224209818 1.0 1.0 41 P48681,A1X283,P40763,Q15648,Q15293,Q12948,P21359,Q15555,Q9H0D6 9 +Cochlea development 0.3613609641048518 0.1877736702973691 0.8510540766640944 1.0 1.0 6 P43034,P33993 2 +Regulation of lamellipodium organization 0.3375026086830724 0.1876097944963117 0.8511825476879171 1.0 1.0 18 O94813,Q16625,P60953,Q7L576,P42345 5 +Dendritic cell differentiation 0.3914473684210685 0.1861109167874076 0.8523577811215266 1.0 1.0 4 P09429,P17931,P01889 3 +Regulation of chromatin assembly 0.3286759207542438 0.1844492810605007 0.8536610122622335 1.0 1.0 11 P26358,Q96ST3,Q6PD62 3 +T cell receptor signaling pathway 0.3356806782936572 0.1829021986543156 0.8548747577230786 1.0 1.0 22 Q5ZPR3 1 +Anion transmembrane transport 0.2719950674647398 0.1826868528519595 0.855043732059058 1.0 1.0 43 Q9UHG3,P41440 2 +Regulation of response to wounding 0.3350806261527934 0.1807523433331848 0.8565619713558801 1.0 1.0 22 Q05397,Q96G23,Q16625,Q9Y251,P42345 5 +Protein localization to axon 0.4589259073072316 0.180377835255467 0.8568559538253862 1.0 1.0 3 O14579 1 +Cerebral cortex development 0.3252610881789258 0.1801571014704121 0.8570292353961704 1.0 1.0 29 O43776,O94813,P07942,P43034,Q96P11,P61586,Q00535,P62995,P19022,P21359 10 +Pyrimidine nucleotide metabolic process 0.3346584656193328 0.1793509815519272 0.8576621182735025 1.0 1.0 17 P22392,Q9H773,P17812,P34896 4 +Replicative senescence 0.4580730023018659 0.178826135740274 0.858074222711575 1.0 1.0 3 O14757,O96017 2 +Thymocyte apoptotic process 0.4580730023018634 0.1788261357402694 0.8580742227115785 1.0 1.0 3 Q07812,O00273 2 +Response to actinomycin d 0.4580730023018631 0.1788261357402689 0.858074222711579 1.0 1.0 3 O95251,P62829 2 +Establishment of golgi localization 0.4579031961658402 0.1785182811844083 0.8583159654786168 1.0 1.0 3 P60953 1 +Regulation of cellular carbohydrate metabolic process 0.3302147427369522 0.1780135149301978 0.858712361882725 1.0 1.0 26 Q9BYT8,P31751,O00763,O75844,P31749 5 +Actin cytoskeleton reorganization 0.332630732119345 0.1776697057269171 0.8589823780093029 1.0 1.0 24 Q9UQB8 1 +Glial cell development 0.3321463515942237 0.1759154810342052 0.8603603429104187 1.0 1.0 24 Q96P11,Q00535,Q93074,P18074,P31751,Q9UPY3,P21359,P31749,P49770 9 +Biological process involved in intraspecies interaction between organisms 0.455992680599675 0.1750791962150959 0.8610174047964734 1.0 1.0 3 Q15334 1 +Response to monosaccharide 0.3292235604703146 0.1743436256944889 0.8615954158565466 1.0 1.0 26 P17612,Q15043,Q96ST3,Q12824,P61586,P22059,Q15120,Q08209 8 +Receptor localization to synapse 0.3254981532742371 0.173979878686611 0.8618812755410294 1.0 1.0 11 Q14168,P57105 2 +Response to interleukin 6 0.371178259180566 0.1738299806722387 0.8619990819108383 1.0 1.0 5 P40763,Q6PD62 2 +Regulation of protein kinase a signaling 0.6410256410256482 0.1736953790694256 0.8621048692915398 1.0 1.0 2 P14174 1 +Positive regulation of protein kinase a signaling 0.6410256410256482 0.1736953790694256 0.8621048692915398 1.0 1.0 2 P14174 1 +Activated t cell proliferation 0.3708456729187426 0.1730462387208712 0.8626150825838539 1.0 1.0 5 P09429,Q14160,P42574,P23396 4 +Synaptic vesicle maturation 0.4540621823422794 0.1716501429463048 0.8637125840781632 1.0 1.0 3 Q15334 1 +Vasoconstriction 0.3698585060875502 0.1707307484920004 0.8644354839916308 1.0 1.0 5 P42892,O00443,P61586,P52306 4 +Regulation of transmembrane transport 0.2812504901502226 0.1707219478429961 0.8644424043002974 1.0 1.0 68 P42858,Q16625,Q13642,Q9BSH4,P27695,P17612,P07384,P31751,Q9HD26,Q96PU5,Q00535,Q15334,O75844,P0CG08,P31749,O43865,Q13546,P62942,Q8N335 19 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.6387245233399064 0.170255690260325 0.8648090564779252 1.0 1.0 2 Q9UPY3 1 +Mitochondrial gene expression 0.2412621693715676 0.1691024470455029 0.8657160601867864 1.0 1.0 49 Q9BQ52,Q567V2,Q9NP81,P34897,Q07021,Q9BSH4,Q9BSK2,Q9Y2R9 8 +Glucan biosynthetic process 0.3216761011823148 0.1682416504943669 0.866393175555553 1.0 1.0 10 P31751 1 +Chemokine c x c motif ligand 2 production 0.6367521367521436 0.1673470764477432 0.867096964713796 1.0 1.0 2 P14174 1 +Positive regulation of chemokine c x c motif ligand 2 production 0.6367521367521436 0.1673470764477432 0.867096964713796 1.0 1.0 2 P14174 1 +Positive regulation of vascular endothelial cell proliferation 0.6367521367521317 0.167347076447726 0.8670969647138096 1.0 1.0 2 P40763 1 +Vascular endothelial cell proliferation 0.6367521367521317 0.167347076447726 0.8670969647138096 1.0 1.0 2 P40763 1 +Trna catabolic process 0.3190286027644926 0.1670416770054681 0.8673372560842019 1.0 1.0 9 Q99575,Q9BQ52 2 +Angiotensin activated signaling pathway 0.6364234056541798 0.1668658678203033 0.8674755900905526 1.0 1.0 2 O43865 1 +Positive regulation of tissue remodeling 0.6364234056541755 0.1668658678202974 0.8674755900905573 1.0 1.0 2 Q08209 1 +Positive regulation of connective tissue replacement 0.6364234056541755 0.1668658678202974 0.8674755900905573 1.0 1.0 2 Q08209 1 +Regulation of connective tissue replacement 0.6364234056541755 0.1668658678202974 0.8674755900905573 1.0 1.0 2 Q08209 1 +Connective tissue replacement 0.6364234056541755 0.1668658678202974 0.8674755900905573 1.0 1.0 2 Q08209 1 +Negative regulation of myosin light chain phosphatase activity 0.63642340565417 0.1668658678202886 0.8674755900905642 1.0 1.0 2 O14920 1 +Negative regulation of bicellular tight junction assembly 0.63642340565417 0.1668658678202886 0.8674755900905642 1.0 1.0 2 O14920 1 +Semi lunar valve development 0.63642340565417 0.1668658678202886 0.8674755900905642 1.0 1.0 2 O94813 1 +Aortic valve morphogenesis 0.63642340565417 0.1668658678202886 0.8674755900905642 1.0 1.0 2 O94813 1 +Telomere organization 0.2701623037023248 0.1664744341021667 0.8677836010516449 1.0 1.0 63 Q9UPR3,P41440,Q9H2U1,P12956,P22626,Q9UQ84,P18887,P78527,Q8IY18 9 +Antigen receptor mediated signaling pathway 0.3287537455594503 0.1638108036660948 0.8698800864762775 1.0 1.0 24 Q5ZPR3 1 +Regulation of pattern recognition receptor signaling pathway 0.3301323163434057 0.1624936508989466 0.8709171276827696 1.0 1.0 18 Q92890,Q07021,O00571,P41440 4 +Negative regulation of membrane permeability 0.6331360946745508 0.1621096882374263 0.8712194770027606 1.0 1.0 2 P42765 1 +Negative regulation of mitochondrial membrane permeability 0.6331360946745508 0.1621096882374263 0.8712194770027606 1.0 1.0 2 P42765 1 +Hippocampus development 0.3277291060196927 0.1617542599224382 0.8714993738810255 1.0 1.0 15 O14949,P43034,Q9H0D6,P18887 4 +Nuclear transcribed mrna catabolic process nonsense mediated decay 0.3293445116332256 0.1615487179210869 0.8716612438646685 1.0 1.0 17 Q9HAU5 1 +Modulation by host of symbiont process 0.3297711577376589 0.1607692969872731 0.8722751080832314 1.0 1.0 21 Q12824,P11498,P50750 3 +Germ cell proliferation 0.6321499013806652 0.1607026412968352 0.8723276090215504 1.0 1.0 2 Q13162 1 +Antigen processing and presentation 0.3289486607236186 0.1593258110769341 0.8734121861950022 1.0 1.0 22 Q9NVJ2,Q9NZ08,Q9UIQ6 3 +Nuclear transcribed mrna catabolic process deadenylation independent decay 0.6305062458908646 0.1583778556870339 0.8741590621415427 1.0 1.0 2 Q96F86 1 +Srp dependent cotranslational protein targeting to membrane 0.3183890398766671 0.1578113081982409 0.8746054876675098 1.0 1.0 10 O76094,Q9UNL2,Q9UHB9 3 +Podosome assembly 0.3495909298540634 0.1572402222780146 0.8750555297622846 1.0 1.0 6 A1X283 1 +Cellular ketone metabolic process 0.3191819886801721 0.1571287863601737 0.8751433511318758 1.0 1.0 29 Q06136,P31751,Q14849 3 +Positive regulation of lamellipodium organization 0.3262649720272274 0.1570299073724552 0.8752212778163895 1.0 1.0 15 Q16625,P60953,Q7L576,P42345 4 +Positive regulation of axon extension 0.3200791960734138 0.1566339798423566 0.8755333210356298 1.0 1.0 11 Q7L576 1 +Digestion 0.3218566434914494 0.1564157358289075 0.8757053344379795 1.0 1.0 12 Q8WTV0,Q9UDY2,P11171,P21399,P53621,O00625 6 +Tissue regeneration 0.3635856361483889 0.1563959760047172 0.8757209088302831 1.0 1.0 5 Q7Z4V5,Q08209 2 +Suppression of viral release by host 0.3632773938795824 0.1557085429039856 0.8762627630462796 1.0 1.0 5 Q14258,P19474,Q9Y3E7,Q13263 4 +Response to peptide hormone 0.3186206080634921 0.1556965580170106 0.8762722103883782 1.0 1.0 88 Q05397,Q16836,P11802,Q9UQB8,O14654,Q92572,P31751,P61026,Q7L576,P78527,P49815,Q9BSK2,P43490,P42345 14 +Hematopoietic stem cell homeostasis 0.3769430001776133 0.1556910448696155 0.8762765562500072 1.0 1.0 4 Q9NVX2 1 +Regulation of protein localization to nucleus 0.240973023257539 0.1554607101773164 0.8764581260501279 1.0 1.0 50 Q96ST3,Q05655,Q6GQQ9,Q9BRK4,Q7Z434,O95071,P14923,P21359,Q13526,P31749,Q96D46 11 +Exploration behavior 0.4443791168441836 0.1551496442768427 0.8767033455145534 1.0 1.0 3 Q15334 1 +T cell differentiation involved in immune response 0.34841020441663 0.1543134333152516 0.8773626059286672 1.0 1.0 6 P42345 1 +Actin modification 0.6275476660092001 0.1542570845615778 0.8774070337908522 1.0 1.0 2 Q86TU7 1 +Establishment of spindle orientation 0.3209822599525195 0.153667108369392 0.8778722204085598 1.0 1.0 12 Q15334,P43034,P42858 3 +Positive regulation of supramolecular fiber organization 0.248905074097061 0.1530252817949306 0.878378338101397 1.0 1.0 46 O95429,Q16625,Q9UQB8,Q7L576,P42345,P35080,Q96J84 7 +Positive regulation of gtpase activity 0.3046813210806745 0.1528679421741359 0.8785024171649958 1.0 1.0 34 P21359,P31751,Q15555,P49815 4 +Antigen processing and presentation of peptide antigen 0.3223485797599967 0.1528341634342726 0.8785290556914696 1.0 1.0 13 Q9NZ08 1 +Oocyte construction 0.6262327416173513 0.1524519398236707 0.8788304937335718 1.0 1.0 2 Q9BQA1 1 +Smooth muscle cell proliferation 0.3273249157239107 0.1523026904673267 0.8789482029908946 1.0 1.0 19 Q53EL6,P26358,P61586,P12956,P78527,P31749 6 +Response to ionizing radiation 0.2936969942134082 0.1520542970900112 0.8791441106039599 1.0 1.0 37 Q86UE8,Q96RU2,P22681,Q15046,P78527,O75844 6 +Developmental growth involved in morphogenesis 0.2542305789021898 0.1498968934844574 0.8808459626669547 1.0 1.0 45 Q96F07,Q8N0X7,Q96ST3,Q99829,P43034,Q96PU5,Q00535,Q93074,Q15648,Q7L576,Q9BRK4 11 +Nik nf kappab signaling 0.3258190360024224 0.1475725191890501 0.8826801441126664 1.0 1.0 21 Q53EL6,Q99829,P61586,Q99627,Q13418,O00571,Q9UPY3,Q9GZN8,P31749 9 +Negative regulation of mapk cascade 0.3118675654036162 0.1472205843645188 0.8829579136511001 1.0 1.0 31 P57105,P30153,Q8IV63,P78318,P51452,P43034,Q05655,Q96KB5,P21359,Q96J02,Q13526,P31689 12 +Regulation of stem cell differentiation 0.3254309911082358 0.1471678324921395 0.8829995500536871 1.0 1.0 18 O43809,Q9Y6C9,Q9H2U1,Q12948,P78527,Q96J02 6 +Pyrimidine nucleobase biosynthetic process 0.3344596434859781 0.1464032524582401 0.8836030598866136 1.0 1.0 7 P17812,P42345 2 +Response to cisplatin 0.6213017751479247 0.1458264517248949 0.8840583936592064 1.0 1.0 2 P09601 1 +Regulation of system process 0.247584048256816 0.1456413092958302 0.884204555554567 1.0 1.0 54 P17612,P15924,Q9UQB8,P50750,O75844,P14923 6 +Regulation of endocytosis 0.2369053689377029 0.1446985089157603 0.884948916481491 1.0 1.0 49 P57105,P61978,P41440,Q15036,P22681,Q96PU5,Q96CW1,P60953,Q15334,P49815,Q08209,Q99816 12 +Regulation of nervous system development 0.2640056379425535 0.1445610048452888 0.8850574873671164 1.0 1.0 62 Q8N0X7,O14744,Q96G23,P43034,Q9H2U1,Q9UQB8,Q00535,Q96P11,Q15154,P55209,Q7L576,O75746,Q9UPY3,P21359,Q08209,P31749,P42345 17 +Mammary gland morphogenesis 0.3577389098100259 0.143629521356861 0.8857930276836121 1.0 1.0 5 P07384 1 +Positive regulation of protein import 0.3229431040946663 0.1434177911582254 0.8859602329072132 1.0 1.0 16 O14737,O00410,P62826,Q05655,Q7Z434,O95071,P14923 7 +Positive regulation of membrane depolarization 0.4370272936533947 0.1434007823903959 0.8859736651030743 1.0 1.0 3 Q12955,P09874 2 +Cytoplasmic microtubule organization 0.3219419710796242 0.1433764910462712 0.8859928485654791 1.0 1.0 15 Q9H2G2,Q7Z460,P43034,P61586,Q15154,Q96CW5 6 +Negative regulation of canonical wnt signaling pathway 0.3206623163129133 0.1431566571223025 0.8861664597730678 1.0 1.0 14 P19022,Q9BRK4,P48729 3 +Base excision repair gap filling 0.3113138897722843 0.1430798203609045 0.8862271419737997 1.0 1.0 9 Q07864 1 +Activation of protein kinase activity 0.3175220672274604 0.142960543659346 0.8863213426422551 1.0 1.0 12 Q99627,Q96M27 2 +Signal release 0.2468470367947529 0.1424170531999146 0.8867505931751201 1.0 1.0 46 P08237,Q16836,Q7L0J3,Q00535,Q4J6C6,P62820,P22059,Q8NE86,P14174,Q13555,P21359,P35080,Q08209 13 +Positive regulation of stem cell proliferation 0.3700657894736968 0.1424088142948371 0.886757100545126 1.0 1.0 4 O95251,Q96AC1,Q00839 3 +Establishment or maintenance of monopolar cell polarity 0.311087169372564 0.1423954159711698 0.8867676830173197 1.0 1.0 9 Q92538,P61586 2 +Actin filament based transport 0.3323920799054349 0.1410456278847892 0.8878338967729551 1.0 1.0 7 O43795 1 +Regulation of vesicle size 0.4354554700735586 0.1409759955062785 0.8878889057444654 1.0 1.0 3 Q96CW1 1 +Lymphocyte anergy 0.6170282708744295 0.1402673534115372 0.8884487574826052 1.0 1.0 2 Q96J02 1 +T cell tolerance induction 0.6170282708744295 0.1402673534115372 0.8884487574826052 1.0 1.0 2 Q96J02 1 +Detection of other organism 0.6170282708744184 0.1402673534115228 0.8884487574826165 1.0 1.0 2 P04439 1 +Negative regulation of natural killer cell mediated immunity 0.6170282708744184 0.1402673534115228 0.8884487574826165 1.0 1.0 2 P04439 1 +Protection from natural killer cell mediated cytotoxicity 0.6170282708744184 0.1402673534115228 0.8884487574826165 1.0 1.0 2 P04439 1 +Regulation of rig i signaling pathway 0.3319042195698605 0.1397936173597523 0.8888230563854134 1.0 1.0 7 Q92890,Q07021,Q9NUD5 3 +Regulation of chromatin binding 0.3558434286161116 0.1396147623983522 0.8889643761591755 1.0 1.0 5 Q7Z5K2,Q08209 2 +Regulation of hematopoietic stem cell proliferation 0.6163708086784968 0.1394271302437136 0.8891126349036165 1.0 1.0 2 O95251 1 +Collagen biosynthetic process 0.3556465164505779 0.1392011844441383 0.8892911725661721 1.0 1.0 5 Q92791,P50454 2 +Spliceosomal snrnp assembly 0.321503497693216 0.1390274846396125 0.8894284303504698 1.0 1.0 24 Q9Y312,P57678,O95400 3 +Regulation of mrna splicing via spliceosome 0.2565108218553276 0.1378440500765121 0.8903636697096982 1.0 1.0 59 P14866,P52756,P17844,P22626,P98179,P78362,P08621,Q06787,Q07021,Q9BWF3,Q96MU7,Q92879,Q4G0J3,P61978,Q8IY67,P51114,Q07666,P26368,Q14011,Q96PU8 20 +Negative regulation of cilium assembly 0.4330812232818056 0.1373714088045374 0.8907372292430971 1.0 1.0 3 P50395,P50570 2 +Negative regulation of phosphatase activity 0.3090352799340384 0.1362534858862187 0.8916208937545496 1.0 1.0 9 O95429 1 +Regulation of systemic arterial blood pressure by endothelin 0.6117685733070387 0.1336572483282218 0.8936736126399296 1.0 1.0 2 P61586 1 +Positive regulation of cell aging 0.3651491062697358 0.1333661551708769 0.8939038105231634 1.0 1.0 4 O43324 1 +Ossification 0.2679511601163434 0.1331936461876992 0.8940402356839554 1.0 1.0 65 P17612,Q05397,O60506,Q13951,P18074,Q12948,Q6W2J9,P21359,O75844 9 +Regulation of nucleotide biosynthetic process 0.3289722694673663 0.1323676337106015 0.8946935139341705 1.0 1.0 7 Q15120 1 +In utero embryonic development 0.3235940156712229 0.1322794399052151 0.8947632690396368 1.0 1.0 93 P61803,O43772,Q15293,Q99873,O95067,Q96MU7,Q12948,Q9NVX2,Q14574,P23786,Q12824,P20248,P18074,Q14691,Q6W2J9,Q96EK5,P31749,Q8IWS0,Q96ST3,Q9BRT9,P78330,Q6PD62,Q6GQQ9,P53992,Q9UNS2 25 +Negative regulation of erk1 and erk2 cascade 0.3155892096328514 0.1321206266652033 0.8948888812094364 1.0 1.0 13 P57105,Q8IV63,P51452,Q96P70,Q13526 5 +Cellular glucose homeostasis 0.3200725453719087 0.1301040130116388 0.896484135185424 1.0 1.0 22 P17612,Q15043,Q96ST3,Q12824,P22059,Q15120 6 +Chromosome condensation 0.3187500036053877 0.1300097349040742 0.8965587247235014 1.0 1.0 24 Q8IY18,O95831 2 +Neural tube development 0.3045003089492393 0.129828418359757 0.8967021785949478 1.0 1.0 32 P17612,O95487,Q96Q89,Q93074,O75787,P21359,P49815 7 +Second messenger mediated signaling 0.3203759616526429 0.1298043328568492 0.8967212347971223 1.0 1.0 20 P17612,P30153,P42858,Q8IWX8,Q8NE86,O75844,Q08209,P42345 8 +Positive regulation of neuron projection development 0.3114512975512349 0.1295756459974992 0.8969021724549218 1.0 1.0 29 Q32P28,Q9UQB8 2 +Lipid storage 0.3201009128179845 0.1293709689509624 0.8970641180314018 1.0 1.0 19 Q9H6V9 1 +Positive regulation of monooxygenase activity 0.3277319962402178 0.1292772649312915 0.8971382604167728 1.0 1.0 7 Q8WTV0,P31749 2 +Cellular response to inorganic substance 0.288009525798886 0.129028130415199 0.8973353900227976 1.0 1.0 37 Q5TDH0,O95831,P24941,Q99829,Q15334,Q14168,P31749 7 +Reelin mediated signaling pathway 0.4273786777277961 0.1289984228711024 0.8973588967691337 1.0 1.0 3 P98155 1 +Mitochondrial proton transporting atp synthase complex assembly 0.6078238001314855 0.1288664520955254 0.8974633226306927 1.0 1.0 2 Q5TC12 1 +Muscle contraction 0.2915784118265379 0.1284726892001038 0.8977749099605716 1.0 1.0 36 P17612,P60660,Q86U42,P15924,Q96PU5,Q8N335,P14923,P42345 8 +Histone deubiquitination 0.3270791952188165 0.1276629115307922 0.898415742175448 1.0 1.0 7 Q9Y6J9,Q99496,Q9Y4A5 3 +Fructose 6 phosphate metabolic process 0.326967402041494 0.1273872975865556 0.898633869391374 1.0 1.0 7 Q06210,P08237,P37837,P19367,P17858,P52789 6 +Neuron death 0.2869285000886348 0.1268393353925969 0.8990675620107442 1.0 1.0 75 Q15392,P78362,O95831,P22681,O43813,Q99720,P31751,P21359,Q01105,P31749 10 +Stem cell proliferation 0.3100561351790357 0.1262860567073386 0.8995054930279518 1.0 1.0 11 O95376 1 +Acetyl coa metabolic process 0.3149284632054756 0.1258468840091258 0.8998531286915616 1.0 1.0 14 Q13085,O00763 2 +Negative regulation of wnt signaling pathway 0.3183151096739685 0.1250292857230076 0.9005003655965023 1.0 1.0 18 P49815,P19022,Q9BRK4,P48729 4 +Regulation of filopodium assembly 0.3115007526464941 0.1249878887805 0.9005331385012576 1.0 1.0 12 Q06787,P60953,Q05655 3 +Activation of gtpase activity 0.3145429625443989 0.1247113844805478 0.9007520442575304 1.0 1.0 14 P31751 1 +Negative regulation of response to external stimulus 0.2866523391758089 0.1237444191932448 0.901517640491218 1.0 1.0 37 P25786,P80303,P28070,O94813,Q96G23,Q07021,P51452,Q05655,Q7Z739,Q92890,Q96KB5,Q9Y3Z3,P14174,Q96J02 14 +Leukocyte proliferation 0.2694645419871335 0.1231678698656998 0.901974167938532 1.0 1.0 41 Q92990,Q05397,P62753,Q96QE3,P17812,Q05655,Q5ZPR3,P14174 8 +Negative regulation of mrna processing 0.3179213656745509 0.1222501479503493 0.9027009119379228 1.0 1.0 20 P61978,P26368,P50750,Q6PD62,P22626 5 +Positive regulation of nervous system process 0.4225209193305903 0.122181275907545 0.9027554550064558 1.0 1.0 3 O75746 1 +Negative regulation of cell adhesion 0.302334633580708 0.122126537492655 0.9027988053056442 1.0 1.0 32 Q92990,Q05397,Q9P258,P51452,Q05655,Q13951,P21359,Q96J02,P31749 9 +Smoothened signaling pathway 0.3156749868971963 0.1213405356054571 0.9034213144316464 1.0 1.0 16 A0AVF1 1 +Regulation of lymphocyte activation 0.2449626862569989 0.1213090177163913 0.9034462776652888 1.0 1.0 55 Q92990,Q96QE3,P51452,P61586,Q13951,Q5ZPR3,P12956,P14174,P78527,Q96J02,P31749 11 +Depyrimidination 0.600591715976326 0.1204510604087048 0.9041258454365138 1.0 1.0 2 P78549 1 +Protein import 0.2990277104836212 0.118149408631999 0.9059492751501176 1.0 1.0 82 O00505,P62826,O95831,O75381,Q9UHD1,O95071,O15397,Q08209,O14737,O00410,Q13148,Q92973,Q9UI26,Q9Y512,Q96P70,P21359,P40855,O60684,Q15648,P37198,Q7Z434,Q5SRE5,P49815,P14923,P31749,Q9Y5L0,P40763,Q05655,O60830,Q9NS69,Q99595 31 +Positive regulation of protein kinase b signaling 0.316394155280416 0.1177911644339507 0.9062331305687326 1.0 1.0 21 Q05397,O95429,Q99829,Q86UE4,Q9Y251 5 +Response to sodium arsenite 0.5976331360946707 0.1171442679190971 0.9067457304762776 1.0 1.0 2 P09651 1 +Import across plasma membrane 0.3160265842875861 0.1170361384845197 0.9068314158863466 1.0 1.0 19 P41440 1 +Negative regulation of carbohydrate metabolic process 0.3022590824115261 0.1166453606385165 0.907141090462088 1.0 1.0 9 O75746,Q00610,P40763 3 +Transforming growth factor beta receptor signaling pathway 0.3135946913445839 0.1166215258333281 0.9071599789736348 1.0 1.0 25 Q05397,Q9Y3F4,Q15750,P40763,Q9UPN9,Q9GZN8,P62942,Q13526 8 +Regulation of dna repair 0.2356724337439054 0.1164779401299763 0.9072737683107912 1.0 1.0 51 P35637,P50750,Q7Z4V5,Q96FW1,P18887,Q9Y4A5 6 +Osteoblast differentiation 0.2472686437559157 0.116445505694394 0.9072994723376278 1.0 1.0 45 Q05397,P17612,O60506,Q13951,P21359 5 +Srp dependent cotranslational protein targeting to membrane translocation 0.3552631578947521 0.1163277608981444 0.9073927849482956 1.0 1.0 4 Q15629,P60468,P61011 3 +Stress activated protein kinase signaling cascade 0.2845801702795748 0.1158354424899576 0.9077829605297024 1.0 1.0 37 Q53EL6,P78318,P51452,P61586,P43034,Q96KB5,P60953,Q96J02,Q99873,O75844,P31689 11 +Epithelial cell proliferation 0.2629041111130948 0.1158230292533145 0.907792798641635 1.0 1.0 42 Q8WTV0,P57105,P07942,P40763,Q15648,P60953,P22392,P78527,P21359,Q9H2J4,P31749 11 +Cytoplasmic sequestering of nf kappab 0.3549342105263325 0.1157870187628704 0.9078213388394376 1.0 1.0 4 O60826,Q9UNN5,O75832 3 +Negative regulation of histone h4 acetylation 0.4172969417954562 0.1151715299456947 0.908309164299054 1.0 1.0 3 Q13363,Q96EB6 2 +Pyrimidine dimer repair 0.5956607495068956 0.114983173061462 0.9084584595255047 1.0 1.0 2 Q96EB6 1 +Regulation of protein secretion 0.2971859346232393 0.1137096714468467 0.9094679455471002 1.0 1.0 33 Q16836,Q32P28,Q15334,P22059,Q16850,Q08209,Q9H4A5 7 +Intrinsic apoptotic signaling pathway in response to osmotic stress 0.5940170940170864 0.1132086630638402 0.909865127692184 1.0 1.0 2 Q92974 1 +Positive regulation of receptor internalization 0.4154032068900986 0.1127120860614806 0.9102588190222036 1.0 1.0 3 Q96CW1 1 +Histone h2a acetylation 0.3031233925622879 0.1125384112754963 0.9103965153761436 1.0 1.0 10 Q86UY6 1 +Sensory organ morphogenesis 0.3142379564304764 0.1120817384988239 0.9107585967484542 1.0 1.0 22 P21359,Q15555 2 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.3102399550339931 0.110762823963167 0.9118044260808988 1.0 1.0 8 Q92890,Q07021,Q9NUD5 3 +Regulation of phosphoprotein phosphatase activity 0.3123409502781619 0.1092476173831299 0.9130060930871826 1.0 1.0 17 Q9UPN7,Q8IV63,P42345,P42858 4 +Polyamine metabolic process 0.3507159345677429 0.1090016760613274 0.9132011609531908 1.0 1.0 4 P52788 1 +Anatomical structure maturation 0.3085748311765273 0.1087406553884372 0.9134081946962334 1.0 1.0 27 P17612,P30153,Q13951,P18074,O75787,P21359 6 +Somatic diversification of immune receptors 0.309739896813821 0.1081564850656888 0.9138715622890066 1.0 1.0 26 Q96QE3,Q9UQ84,P78527 3 +Regulation of meiotic nuclear division 0.4108034092603075 0.106917636285316 0.9148543216591564 1.0 1.0 3 Q12834 1 +Positive regulation of sodium ion transmembrane transporter activity 0.3390439407461941 0.106708238587164 0.9150204464818184 1.0 1.0 5 Q9UHD1,O43707 2 +Adherens junction maintenance 0.5867850098619277 0.1056832922279063 0.915833636975403 1.0 1.0 2 Q07157 1 +Regulation of leukocyte chemotaxis 0.308966800833487 0.1051147344322391 0.9162847676896292 1.0 1.0 15 Q05397,Q07021,Q8NE86,P14174 4 +Neurotransmitter receptor transport endosome to postsynaptic membrane 0.5861275476660022 0.105021793866198 0.9163585153441024 1.0 1.0 2 Q14160 1 +Regulation of cell morphogenesis 0.2559640926810902 0.1049314196724396 0.9164302272913788 1.0 1.0 62 Q05397,Q9P258,Q07021,Q9H2U1,Q9UQB8,P61586,P43034,Q96PU5,Q13418,Q15334,Q7L576,P78527,O75844,Q9HCE1 14 +Attachment of spindle microtubules to kinetochore 0.3107488430624505 0.1047248911225774 0.9165941103036312 1.0 1.0 17 Q9BZD4,Q9P258,P25054,Q8NBT2,P60953,Q9HC35,Q9HBM1 7 +Granulocyte chemotaxis 0.3098745397525717 0.1046664338993358 0.9166404974923756 1.0 1.0 16 Q05397,Q07021,Q92538,Q8NE86 4 +Negative regulation of intracellular transport 0.3098650495154783 0.1046398491641206 0.9166615932022072 1.0 1.0 16 P21359 1 +Negative regulation of immune response 0.3111521821302013 0.1040603676687272 0.9171214420718292 1.0 1.0 18 P25786,P28070,Q9Y3Z3 3 +Positive regulation of developmental growth 0.3112034576467939 0.1024268818373357 0.9184178472578272 1.0 1.0 21 Q96PU5,O00763,Q7L576 3 +Mrna export from nucleus 0.2843712377322568 0.1018999332280702 0.9188361029641684 1.0 1.0 36 Q9ULX6,Q9UPR3,Q9HAU5,Q86U42,Q96MU7,P22626,Q86V81,Q96ST2,Q8NI27 9 +Heart development 0.3090070614535781 0.1014487483561119 0.9191942404582448 1.0 1.0 89 Q9NRG4,Q15036,Q99873,A1X283,P15924,O95487,Q9H2U1,Q93074,Q12948,Q9BQ70,P78527,P21359,Q53EL6,Q05397,Q53GG5,P20248,Q13418,Q15648,P60953,O00763,Q6W2J9,O75844,P62942,P49815,P42345 25 +Regulation of peroxisome proliferator activated receptor signaling pathway 0.5821827744904584 0.1011310769465847 0.9194464086683304 1.0 1.0 2 Q96EB6 1 +Rho protein signal transduction 0.3092184785717516 0.1005063995270336 0.9199423024778284 1.0 1.0 24 Q92888,P41440 2 +Clathrin dependent endocytosis 0.3059475555881388 0.1003334625315803 0.9200795922620048 1.0 1.0 14 Q13492,Q00610,Q5VW38,Q96CW1 4 +Regulation of coagulation 0.3348259956480526 0.0992032045557941 0.9209769305443044 1.0 1.0 5 Q9Y251 1 +Regulation of leukocyte differentiation 0.3086332079825923 0.0987823334763515 0.9213110957231174 1.0 1.0 24 P21359,Q13951,P42345,P78527 4 +Lamellipodium morphogenesis 0.3235681369321945 0.0986683833596339 0.9214015727596558 1.0 1.0 6 Q9ULV4,Q8IZP0,Q92766,Q13596,O60749 5 +Regulation of keratinocyte proliferation 0.3434279878901159 0.0979259166432013 0.921991120383217 1.0 1.0 4 Q15648,P58107 2 +Keratinocyte proliferation 0.3434279878901159 0.0979259166432013 0.921991120383217 1.0 1.0 4 Q15648,P58107 2 +Blood vessel morphogenesis 0.2845238895345531 0.0975081951442517 0.9223228264609148 1.0 1.0 77 Q92990,P78362,O95487,P61586,Q9NZ08,Q12948,P21359,Q05397,P57105,P20248,Q15648,P60953,Q9H2J4,Q9BXJ9,P31749,P14923,O94813,P06756,P40763,P19022,Q86UE4,Q9Y251,Q96PU8 23 +Organelle membrane fusion 0.3033037821041729 0.097204392408506 0.922564079928804 1.0 1.0 28 P31751,Q9NVJ2 2 +Lymphocyte mediated immunity 0.2829657938159052 0.0969789845548306 0.9227430836673852 1.0 1.0 36 Q9NVJ2,Q9UQ84 2 +Positive regulation of activated t cell proliferation 0.5775805391189938 0.096759850086173 0.9229171092573024 1.0 1.0 2 P09429 1 +Positive regulation of myeloid cell differentiation 0.3058455492913019 0.0965324791313083 0.923097679751436 1.0 1.0 15 P40763,P42224,Q15648,P78527,Q99873 5 +Calcium ion transport 0.2335532602283955 0.0963494661997664 0.9232430254495568 1.0 1.0 52 P17612,P42858,Q06787,O76024,P11171,P06756,P61586,Q00535,Q9HC07,Q13555,Q8NE86,P62942,O75844,Q08209,P27695 15 +Leukocyte homeostasis 0.3028884423008106 0.0961369108180402 0.923411836466135 1.0 1.0 13 P62753,P31749,P14174,O95067 4 +Regulation of cation transmembrane transport 0.2477888911264424 0.0951061951269968 0.9242304773843408 1.0 1.0 44 P17612,P42858,P07384,Q06787,Q96PU5,Q00535,P46939,Q13642,Q15334,O43707,Q9BSH4,P62942,Q8N335,P27695 14 +Methylguanosine cap decapping 0.3411184210526432 0.0945857217171728 0.9246438914037682 1.0 1.0 4 Q96F86,Q96C86,Q6P2E9 3 +Rna decapping 0.3411184210526432 0.0945857217171728 0.9246438914037682 1.0 1.0 4 Q96F86,Q96C86,Q6P2E9 3 +Rna 5 end processing 0.298543814124252 0.094307738312385 0.9248647030301342 1.0 1.0 11 Q99575,O15091 2 +Positive regulation of smooth muscle cell apoptotic process 0.3408581395753695 0.0942143784161149 0.924938863254771 1.0 1.0 4 Q53EL6 1 +Trophectodermal cell differentiation 0.3405900538933396 0.093832975739234 0.9252418363864132 1.0 1.0 4 Q6PD62 1 +Regulation of hexokinase activity 0.3988819467280511 0.0930645610391342 0.9258522714050544 1.0 1.0 3 P49792,Q9UNI6 2 +Positive regulation of hexokinase activity 0.3988819467280511 0.0930645610391342 0.9258522714050544 1.0 1.0 3 P49792,Q9UNI6 2 +Negative regulation of cell aging 0.3398258294765481 0.0927517020465326 0.9261008217123818 1.0 1.0 4 P14174 1 +Endoderm development 0.2996831907743102 0.0922071950650711 0.9265334215659298 1.0 1.0 12 P07942,Q93074 2 +Protein polymerization 0.2888432774612811 0.0905686205042625 0.9278353666375788 1.0 1.0 80 P04350,O95429,Q16625,P16333,Q9UQB8,Q96CW5,P61586,Q13526,Q9NUQ9,P35080,P36404,O15511,Q7L576,Q96J84,Q96F07,O94813,Q05655,Q13045,P42345 19 +Developmental pigmentation 0.3019157076288611 0.0903565519139159 0.9280038819579024 1.0 1.0 8 O75787,O14617 2 +B cell mediated immunity 0.3068749064335626 0.0901870528647116 0.9281385727152388 1.0 1.0 21 Q07021,Q96QE3,Q9UQ84,Q05655 4 +Sulfur compound metabolic process 0.3121194609749277 0.0900787852458327 0.9282246075947692 1.0 1.0 92 O60725,Q8WUX2,Q9Y5Y2,O43252,Q13126,Q96RQ3,P21266,Q06520,O15217,O75874,Q6FI81,O00763,Q9NZ01,Q15120,Q13085,P50747,Q13867 17 +Histone h4 k16 acetylation 0.2966961685995941 0.0894689550007191 0.9287092249347766 1.0 1.0 11 Q12824 1 +Regulation of cell substrate junction organization 0.3063926022111184 0.0893636022905733 0.9287929488679472 1.0 1.0 22 Q05397,Q7Z460,Q9H2G2,Q9P258,P51452,P61586,Q15555 7 +Regulation of axonogenesis 0.3055336145993919 0.0880801376819302 0.9298129828484922 1.0 1.0 23 Q8N0X7,O94813,P43034,Q00535,P19022,Q7L576 6 +Centrosome separation 0.3179723502304176 0.0877197024185771 0.9300994597213827 1.0 1.0 6 P43487,O14757,O14965,P37198,P52732 5 +Pattern specification process 0.2865205182123626 0.0875743477129983 0.9302149913861923 1.0 1.0 34 P17612,O75787,P25054,Q93074,Q5VTB9,Q12948,Q9NVX2,Q6W2J9,P78527 9 +Intrinsic apoptotic signaling pathway by p53 class mediator 0.3049707981802922 0.0870457099605289 0.930635178673726 1.0 1.0 18 Q96QE3,P61978 2 +Tissue migration 0.237676732344978 0.0870323956829052 0.93064576176658 1.0 1.0 55 O75340,P67870,Q7Z460,Q13630,P61586,P21359,P35080,Q9NQW6,Q05397,P57105,P58107,P31749,P14923,Q8WTV0,O94813,Q16513,P42224,Q15555,P42345 19 +Protein localization to microtubule organizing center 0.2907974485406397 0.0858922180652609 0.9315520977342452 1.0 1.0 9 Q15154,P37198,Q14789,P25054 4 +Poly a plus mrna export from nucleus 0.2929200471596785 0.0852887921216056 0.9320318016572904 1.0 1.0 10 Q86U42,Q96ST2 2 +Fc epsilon receptor signaling pathway 0.3913186451825015 0.0851258083510833 0.9321613726753402 1.0 1.0 3 O14920,P45985 2 +Positive regulation of aspartic type peptidase activity 0.3913186451824988 0.0851258083510811 0.932161372675342 1.0 1.0 3 Q13492,O75116 2 +Positive regulation of insulin secretion 0.3082303528165523 0.0847317464629727 0.932474656687342 1.0 1.0 7 P22059,Q8NE86 2 +Regulation of erythrocyte differentiation 0.2982548058248261 0.0839858910991544 0.9330676494049408 1.0 1.0 13 Q15648,P40763,Q99873,P78527 4 +Positive regulation of brown fat cell differentiation 0.562787639710709 0.0839013424587292 0.9331348721982892 1.0 1.0 2 Q92766 1 +Regulation of low density lipoprotein particle clearance 0.3159130489451196 0.0838380363031411 0.9331852058641126 1.0 1.0 6 Q92945,P61978 2 +Multivesicular body organization 0.2994879320275614 0.0832128934023425 0.933682260844463 1.0 1.0 14 Q92783,Q9H9H4,Q96EY5 3 +Positive regulation of ubiquitin dependent protein catabolic process 0.2966646125870597 0.0824467014734372 0.9342915000249918 1.0 1.0 29 Q05397,O95376,O43765,Q12834,P48729,P31749 6 +Cell cycle g1 s phase transition 0.2467885889238586 0.0822046550536382 0.9344839717791648 1.0 1.0 60 P62753,Q07864,P24941,P20248,P25054,Q96DY7,P11802,Q13642,O00743,O00571,Q9NPI1,P78527,Q07666,Q08209,P31749 15 +Regulation of heart contraction 0.303934394889911 0.0821713392432188 0.9345104643218572 1.0 1.0 21 P17612,P15924,O75844,P14923 4 +Blastocyst development 0.2944477112605566 0.0815242647684148 0.9350250286070764 1.0 1.0 30 Q12824,Q9BRT9,Q6PD62,Q14691,Q9NVX2,Q6W2J9,Q8IWS0 7 +Cellular response to light stimulus 0.296344014365238 0.0815072549816733 0.935038555436891 1.0 1.0 29 Q96RU2,Q9H2U1,Q96K76,Q05655,Q96KB5,P31751,Q15555 7 +Pancreas development 0.2980947453950056 0.0814964377423867 0.935047157727035 1.0 1.0 8 P31749 1 +Substrate adhesion dependent cell spreading 0.3022526939052079 0.080650676076232 0.9357197637529178 1.0 1.0 24 Q05397,O15144,Q9P258,P07942,Q07021,P06756,P61586,Q13418,P60953,P62820 10 +Regulation of ubiquitin dependent protein catabolic process 0.2401454952544806 0.0799542140801802 0.9362736712020636 1.0 1.0 57 Q92990,Q05397,O95376,O43765,Q12834,Q86UE8,P24941,P48729,O15372,Q14145,O14980,Q96KB5,Q9H2J4,P31749,O60826 15 +Mannosylation 0.2884307006525554 0.0799267277739192 0.9362955321388204 1.0 1.0 9 Q9H553,Q9BV10 2 +Regulation of endothelial cell migration 0.2957128998272437 0.0796681826266424 0.9365011655769826 1.0 1.0 29 Q05397,Q8WTV0,P57105,O94813,P61586,P21359,P14923,P31749 8 +Tetrapyrrole metabolic process 0.3024528775654213 0.0791302216456078 0.936929045477654 1.0 1.0 19 P06132,P30519,O14678 3 +Cellular carbohydrate biosynthetic process 0.3000104526979342 0.0782757031898951 0.9376087441965576 1.0 1.0 16 P31751,Q7LGA3 2 +Forebrain development 0.2437835090235746 0.0780838535491653 0.9377613509770522 1.0 1.0 59 O14949,O43776,Q96ST3,O94813,P07942,P43034,Q96P11,P61586,Q00535,O15511,Q15154,P62995,P19022,P18887,P21359,Q9H0D6,P27695 17 +Protein maturation 0.261609517959295 0.0765746896880752 0.93896189452154 1.0 1.0 68 P17612,Q5TDH0,Q15392,Q9BXJ9,Q86UY6,Q9BU89,Q9NRN7 7 +Regulation of secretion 0.2795071807861328 0.0764869430942067 0.9390317014460168 1.0 1.0 77 P22059,Q16850,Q08209,P27695,Q9H4A5,Q7Z460,Q16836,P08237,Q06787,Q32P28,P61026,Q7L0J3,P21359,P35080,Q00535,Q15334,Q8NE86,P14174,Q92783,Q4J6C6,Q99816 21 +Telomere capping 0.2933074596531568 0.0759229788748692 0.9394803751223466 1.0 1.0 12 P18887 1 +Neurotransmitter transport 0.2996952489882269 0.0758310696750007 0.9395534972567644 1.0 1.0 25 P21359,P41440 2 +Rna phosphodiester bond hydrolysis endonucleolytic 0.2974402995153598 0.0757372823118174 0.9396281141664118 1.0 1.0 27 P78316,O15091,Q9BQ52,Q99575,Q96F86,Q9UQ84 6 +Nuclear transcribed mrna catabolic process 0.2268383922659545 0.0756598842103078 0.939689692233991 1.0 1.0 51 Q9UPR3,Q9HAU5,Q6PGP7,P17844,Q9H2U1,Q9H0D6,P60228,O60506,Q96F86,Q969T7 10 +Granulocyte activation 0.3113917992770362 0.0755936837963134 0.939742361687546 1.0 1.0 6 Q15046 1 +Polysaccharide metabolic process 0.3004060534613015 0.0751308730193078 0.9401105841170424 1.0 1.0 18 Q00610,P08237,P31751,P46020,Q7LGA3,P31749 6 +Nucleoside diphosphate catabolic process 0.5512820512820409 0.0751060817436035 0.9401303089630486 1.0 1.0 2 Q9UKK9 1 +Ribonucleoside diphosphate catabolic process 0.5512820512820409 0.0751060817436035 0.9401303089630486 1.0 1.0 2 Q9UKK9 1 +Negative regulation of leukocyte mediated immunity 0.3198527554811412 0.0749964841454872 0.9402175092619433 1.0 1.0 5 P04439,P09601 2 +Regulation of small molecule metabolic process 0.2225445451978012 0.0749168112494044 0.9402809007028772 1.0 1.0 49 Q9BYT8,O75746,P31751,Q9UBM7,O00763,Q15120,O75844,P31749,P36404 9 +Mitotic g1 s transition checkpoint signaling 0.2948906327908235 0.0743139827637777 0.9407605511602012 1.0 1.0 8 P78527 1 +Positive regulation of g protein coupled receptor signaling pathway 0.3252267320633213 0.0737714280055045 0.941192262206991 1.0 1.0 4 Q15043 1 +Regulation of calcium ion transmembrane transport 0.3003097850080674 0.0735992437782869 0.9413292728862857 1.0 1.0 19 P17612,P42858,Q00535,P62942,P27695 5 +Positive regulation of histone h3 k4 methylation 0.2903210537218842 0.0734054106448297 0.9414835121414622 1.0 1.0 11 P26358,Q6PD62 2 +Circadian rhythm 0.2607744161364966 0.0730500740163311 0.9417662706143246 1.0 1.0 40 O14744,Q96EB6,Q96ST3,Q13148,Q13330,Q9Y2K7,Q93008,Q16531,P23246,Q9BWF3,Q93009,P42345,P78527,P43490,Q15233 15 +Membrane biogenesis 0.2985858946190409 0.0728306097789839 0.9419409125489652 1.0 1.0 25 Q96CP7,Q9H6H4,P41440 3 +Regulation of substrate adhesion dependent cell spreading 0.2992604936805971 0.0722278316476752 0.9424205965596 1.0 1.0 18 Q05397,O15144,Q9P258,Q07021,Q13418,P60953 6 +Developmental maturation 0.2683852231169866 0.0719972298476264 0.9426041123931864 1.0 1.0 38 P17612,P30153,P61586,Q13951,P18074,Q15334,O75787,P21359 8 +Female meiotic nuclear division 0.2849682041194171 0.0714393477698524 0.9430480946004384 1.0 1.0 9 Q15645,P30153,P53350,O95067 4 +Negative regulation of oxidative phosphorylation 0.3762727584776587 0.0712091231333838 0.9432313206409112 1.0 1.0 3 P61586 1 +Regulation of carbohydrate metabolic process 0.288265290805786 0.0696081867128145 0.9445055206943648 1.0 1.0 31 Q00610,Q96EB6,Q9BYT8,Q16531,P40763,O75746,Q93009,P31751,Q9UNI6,O00763,Q15120,O75844,P31749,P36404 14 +Protein complex oligomerization 0.2374176067710226 0.0685758399118264 0.9453272505408026 1.0 1.0 57 Q13085,O43809,Q9NXV2,P34897,Q6DD88,P35637,Q9H9S5,Q99720,Q8NE86,Q9Y3Z3,P14174,O00763,Q14168,Q99873,P34896 15 +Carbohydrate derivative transport 0.2976472205053789 0.0681988822989001 0.9456273166980352 1.0 1.0 18 P98155,P41440 2 +Lymphocyte activation involved in immune response 0.2927732990013237 0.0668044808900168 0.946737356146456 1.0 1.0 28 Q96QE3,Q9UQ84,P42345 3 +Negative regulation of camp dependent protein kinase activity 0.3706017757316708 0.0665832440566469 0.9469134854459638 1.0 1.0 3 P13861,Q96EB6 2 +Negative regulation of activated t cell proliferation 0.3706017757316649 0.0665832440566421 0.9469134854459677 1.0 1.0 3 Q14160,P42574 2 +Aorta development 0.2912762292482063 0.0664831883853473 0.94699314181983 1.0 1.0 8 O95487 1 +Rna export from nucleus 0.2225923127056415 0.0664826627552276 0.9469935602861584 1.0 1.0 50 Q9ULX6,Q9UPR3,P84103,Q9HAU5,O43592,Q86U42,Q96MU7,P22626,Q86V81,Q96ST2,Q5SRE5,Q07666,Q8NI27 13 +Regulation of smooth muscle cell differentiation 0.3059333870775987 0.0661473881867512 0.9472604831200304 1.0 1.0 6 Q53EL6,P26358 2 +Postsynaptic cytoskeleton organization 0.3180921052631705 0.0656248272320878 0.9476765224433938 1.0 1.0 4 P07196,Q16352,Q16643 3 +Regulation of mitotic centrosome separation 0.3177631578947457 0.0652665768786948 0.9479617533712124 1.0 1.0 4 O14757,P52732,P43487 3 +Regulation of lipid storage 0.2846170794006948 0.0649465046912955 0.9482165933383396 1.0 1.0 10 Q8WTV0,P06756,O00763 3 +Negative regulation of small molecule metabolic process 0.2954664483360026 0.0646629195370475 0.9484423869285852 1.0 1.0 17 O75746,P31749,O60678,O00763 4 +Male meiotic nuclear division 0.3679710621506072 0.0645476949554345 0.948534131180129 1.0 1.0 3 Q9Y2W6,Q15645 2 +Transport along microtubule 0.2237861659089228 0.0643897843640567 0.9486598640445452 1.0 1.0 47 Q9NZ32,P42858,O75381,P43034,Q9NVJ2,A0AVF1,Q15154,Q92572,Q14168,P62820,O60333 11 +Microtubule based transport 0.2237861659089228 0.0643897843640567 0.9486598640445452 1.0 1.0 47 Q9NZ32,P42858,O75381,P43034,Q9NVJ2,A0AVF1,Q15154,Q92572,Q14168,P62820,O60333 11 +Endosome to lysosome transport 0.2952758526273251 0.0642018844715987 0.9488094769013132 1.0 1.0 17 Q9NVJ2 1 +Cellular response to iron ion 0.5341880341880274 0.0638573637557264 0.9490838017457636 1.0 1.0 2 P09601 1 +Stress granule disassembly 0.3666557053600842 0.0635556451306994 0.949324050355737 1.0 1.0 3 Q07866,P55072 2 +Establishment of epithelial cell polarity 0.2971898899696988 0.0629232794632142 0.9498275972430484 1.0 1.0 7 P60953,P61586 2 +Regulation of brown fat cell differentiation 0.3154605263157972 0.0628010092219465 0.94992496221446 1.0 1.0 4 Q92766,Q96EB6,Q00839 3 +Production of molecular mediator of immune response 0.2754462152448646 0.0625000506333988 0.9501646216207268 1.0 1.0 35 Q96QE3,Q9H2U1,Q9UQ84,P14174,Q9Y3Z3,Q7Z434,P78527 7 +Indolalkylamine metabolic process 0.5315581854043276 0.0623089790358232 0.9503167781362312 1.0 1.0 2 Q04656 1 +Positive regulation of b cell activation 0.2855102338477591 0.0619363412797573 0.9506135268839626 1.0 1.0 11 Q96QE3,P14174 2 +Myeloid cell development 0.2891880626642868 0.0617458633615144 0.9507652159424848 1.0 1.0 13 P62753,Q8IZP0,P43034,Q9NX58,Q15648,P18074 6 +L ascorbic acid metabolic process 0.3636961525813939 0.0613853328684399 0.9510523330059336 1.0 1.0 3 P14550,P11166 2 +Type i interferon production 0.291932647242261 0.0608936612355493 0.9514438976806892 1.0 1.0 27 O14802,P41440,Q9H2U1,P42224,Q92890,Q9BUI4,O60828,O00571,Q7Z434,Q96J02 10 +Granulocyte migration 0.2937636033684992 0.0605777085156166 0.9516955269406028 1.0 1.0 17 Q05397,Q07021,Q92538,Q8NE86 4 +Maintenance of cell number 0.2929065182653891 0.0604310327173491 0.9518123432801802 1.0 1.0 26 P40763,Q6PD62,Q93074,Q15154,P19022,Q9Y6J9,Q8IY18 7 +Exocytosis 0.2574741465468462 0.0602231907359984 0.9519778756976012 1.0 1.0 68 P22681,P27695,Q96A65,Q7Z460,Q06787,Q7Z6M1,Q9NVJ2,Q9BRK5,Q9UPT5,P61026,Q7L0J3,P35080,Q7Z392,Q00535,Q15334,Q68EM7,Q92783,Q4J6C6,Q99816 19 +Muscle cell proliferation 0.294451951300901 0.0601427128496157 0.9520419715781984 1.0 1.0 24 Q53EL6,P26358,P61586,P12956,Q12948,P78527,P31749 7 +Positive regulation of mammary gland epithelial cell proliferation 0.5259697567389754 0.0591718513638596 0.9528152297035452 1.0 1.0 2 Q92766 1 +Lens development in camera type eye 0.3082796669967413 0.0588416493285443 0.9530782345448175 1.0 1.0 5 Q15648 1 +Negative regulation of lymphocyte mediated immunity 0.3115131578947467 0.0587441793761283 0.953155870021288 1.0 1.0 4 P04439,Q96FV9,P01889 3 +Ribonucleoprotein complex disassembly 0.3080227935977641 0.0585077521519356 0.9533441877501724 1.0 1.0 5 Q14562 1 +Establishment of centrosome localization 0.3110368984387267 0.0582690477690101 0.9535343219118724 1.0 1.0 4 P43034 1 +Positive regulation of protein containing complex assembly 0.2306314061752049 0.0577761696756987 0.9539269203069654 1.0 1.0 55 Q9UQB8,O95429,Q96J84 3 +Response to oxidative stress 0.303712232483698 0.0575762299636174 0.954086183996802 1.0 1.0 92 Q15392,P30519,O95831,O43813,O75306,Q7Z2K6,Q99720,P18074,P28074,O75874,P18887,P39210 12 +Protein localization to extracellular region 0.2222812050331351 0.0570205102162402 0.9545288569304547 1.0 1.0 51 Q16836,P43034,Q32P28,Q15334,P61026,P22059,Q13555,Q16850,Q08209,Q9HCU5,Q9H4A5 11 +Axo dendritic transport 0.2915555989083366 0.0569879251281993 0.95455481386156 1.0 1.0 26 Q9NZ32,P43034,Q9NVJ2,O14617,Q92572,Q14168,P27695,O60333 8 +Histone h2a phosphorylation 0.3051061619441189 0.0547904214244804 0.9563054315367804 1.0 1.0 5 O75844 1 +Membrane lipid biosynthetic process 0.291125913667872 0.0536371378230337 0.9572242673823064 1.0 1.0 25 P20248,Q96G23,O15270,Q06136,P37287,Q92643,Q05655,P22059,Q9H490,Q99805 10 +Acylglycerol homeostasis 0.3516801760706592 0.0534211990612503 0.957396314919336 1.0 1.0 3 Q8WTV0 1 +Female meiosis chromosome segregation 0.3510327406110477 0.0530292771843007 0.9577085807056628 1.0 1.0 3 P53350 1 +Skeletal muscle cell differentiation 0.297737350631319 0.0529952678876705 0.9577356780956912 1.0 1.0 6 Q9BYT8 1 +Neuron projection arborization 0.291183708751464 0.0520941332368922 0.958453687619417 1.0 1.0 7 Q9HCE1 1 +Cell projection assembly 0.2905388145870358 0.0517526316155752 0.9587257994300464 1.0 1.0 86 O95429,A6NIH7,Q16625,P16333,P42858,Q15154,P27695,Q96A65,Q06787,Q15019,Q92538,P35080,Q4KMP7,O15144,Q9P258,P25054,P60953,Q7L576,P62820,O94813,Q05655,A0AVF1,Q9H4M9,Q15555,P42345 25 +Sprouting angiogenesis 0.2859464163583057 0.0507166735476194 0.9595512901775948 1.0 1.0 14 P60953,P57105,P61586,P31749 4 +Peptidyl lysine modification 0.3167380475949735 0.0499779152664974 0.9601399873882874 1.0 1.0 100 Q9H7B4,P10412,Q12824,Q9NRG4,Q9NRF9,P26358,O75448,O75844,Q86UY6,Q6W2J9,Q9NPI1,Q9BU89,Q9Y6J9,Q96ST2,Q8IY18,Q01105,Q9Y4A5 17 +Regulation of translation at synapse modulating synaptic transmission 0.3021634653945626 0.049967023364175 0.9601486670246184 1.0 1.0 4 Q7L576 1 +Regulation of type i interferon mediated signaling pathway 0.2816210543284289 0.0486642378673063 0.9611868761387736 1.0 1.0 12 Q9Y3Z3,Q7Z434 2 +Positive regulation of exosomal secretion 0.2824947810183655 0.0486566690490042 0.9611929080365278 1.0 1.0 8 Q92783 1 +Cartilage development 0.2831013941910886 0.0479625771938194 0.9617460673366768 1.0 1.0 13 Q15043,P50454,P20248,O75844 4 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.5019723865877579 0.0479015141638033 0.961794732649617 1.0 1.0 2 P23396 1 +Regulation of transcription by rna polymerase iii 0.279059647478968 0.0474431791275103 0.9621600157788006 1.0 1.0 11 Q9BUI4,P42345 2 +Trna transcription 0.2990131578947506 0.0472644719324877 0.9623024437117542 1.0 1.0 4 Q12789,Q9Y5Q9,P62875 3 +Magnesium ion transport 0.3387043735613311 0.0462460597425228 0.9631141313577088 1.0 1.0 3 Q8IUH4,Q8N4V1 2 +Exocytic process 0.2873478848951109 0.0458699577040938 0.9634138992421836 1.0 1.0 17 Q7Z6M1,P61026 2 +Negative regulation of phosphorus metabolic process 0.2944717052534216 0.0453496061999475 0.9638286480533642 1.0 1.0 89 Q9H7B4,O95429,Q16625,P22681,P31689,P30153,P51452,Q96KB5,P78527,P21359,Q53EL6,Q13217,P25054,P31749,Q96J84,O95684,O94813,Q05655,P62942,P49815,Q8N335,Q99816 22 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.2150859587053095 0.0452018145961072 0.9639464478919286 1.0 1.0 49 Q92990,O95376,O43765,Q12834,Q86UE8,P24941,P48729,Q14145,O14980,Q96KB5,P31749 11 +Negative regulation of endoplasmic reticulum unfolded protein response 0.2924725160644634 0.0451912203383279 0.9639548922574788 1.0 1.0 6 P16333 1 +Cell cycle dna replication 0.2876602824211566 0.0448034576934305 0.9642639690215076 1.0 1.0 18 Q96QE3,P33993,Q9BY42,Q14691,P51530,P33991,O75844 7 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.2964791049687462 0.0445766531189947 0.9644447522689674 1.0 1.0 5 Q13162,P13674,Q96HE7,P07237 4 +Cytoskeleton dependent intracellular transport 0.2249715020162717 0.0441688691948777 0.9647697966096324 1.0 1.0 54 Q9NZ32,P42858,O75381,P43034,Q9NVJ2,A0AVF1,O14617,Q15154,O43795,Q92572,P60953,O43707,Q14168,P62820,P27695,O60333 16 +Protein maturation by iron sulfur cluster transfer 0.2947368421052705 0.043793911390129 0.9650686804365438 1.0 1.0 4 Q86SX6,Q96T76,Q9H3K6 3 +Central nervous system neuron axonogenesis 0.2943197843614628 0.0434674091611906 0.965328943681947 1.0 1.0 4 P43034 1 +Response to mechanical stimulus 0.2859399081578353 0.0432898812908452 0.9654704572224682 1.0 1.0 26 Q05397,P42858,P78330,P61586,Q99439,P19022,P14923 7 +Substrate dependent cell migration 0.2770320787563811 0.0430971629946598 0.965624080802232 1.0 1.0 11 P16333,Q92625,O94813,Q13043 4 +Positive regulation of rig i signaling pathway 0.3317987504110478 0.0429793970491891 0.965717957448031 1.0 1.0 3 Q9NUD5,Q14671 2 +Dna methylation dependent heterochromatin assembly 0.2744068182317414 0.0422111692118815 0.966330358753832 1.0 1.0 10 P26358,Q9NRZ9,Q96EB6,Q13263 4 +Meiotic cell cycle checkpoint signaling 0.3291680368299954 0.0418289655931581 0.9666350440104132 1.0 1.0 3 Q15645,Q08J23 2 +Positive regulation of pathway restricted smad protein phosphorylation 0.3291680368299894 0.0418289655931556 0.9666350440104152 1.0 1.0 3 P67870,O00560 2 +Regulation of chromatin organization 0.2853639472329566 0.0415402526667298 0.966865203545858 1.0 1.0 17 P26358,Q96ST3,Q86UE8,Q6PD62 4 +Insulin processing 0.4822485207100505 0.0409928023694482 0.9673016339177942 1.0 1.0 2 Q96HE7 1 +Axonogenesis involved in innervation 0.4812623274161589 0.0406962444135596 0.9675380556408072 1.0 1.0 2 P42892 1 +Innervation 0.4812623274161589 0.0406962444135596 0.9675380556408072 1.0 1.0 2 P42892 1 +Protein localization to cytoplasmic stress granule 0.2890334560704691 0.0403612903504412 0.9678050909114866 1.0 1.0 6 O00571 1 +Negative regulation of autophagy 0.2860526069044397 0.0401021623390975 0.968011677892763 1.0 1.0 24 Q86UE8,P08621,P49815,Q9NNW5,P31749,P42345 6 +Protein poly adp ribosylation 0.4783037475345046 0.0398324345105124 0.968226717742843 1.0 1.0 2 Q7Z2W4 1 +Calcium ion regulated exocytosis of neurotransmitter 0.4776462853385852 0.0396456644145409 0.968375621098694 1.0 1.0 2 Q15042 1 +Oxidative phosphorylation 0.2333852615588521 0.0382439837317971 0.9694931525821702 1.0 1.0 59 Q9UDW1,Q7KZN9,P34897,P28331,O75306,Q9BSK2,P03886 7 +Meiotic chromosome condensation 0.2871091123531568 0.0381486951969235 0.9695691263913316 1.0 1.0 4 Q15003,Q15021 2 +Positive regulation of protein binding 0.2833719600013769 0.0373547262034527 0.970202170710854 1.0 1.0 26 Q96D46 1 +Regulation of protein kinase activity 0.3053421716287576 0.0371619739974871 0.9703558580096132 1.0 1.0 96 Q9H7B4,P98155,Q99816,P42858,P22681,Q96M27,O95067,P31689,P51452,P61586,P21359,Q53EL6,Q05397,P20248,P25054,Q15334,O00571,P14174,P31749,O95684,Q05655,Q99627,P12956,P49815,P42345 25 +Mitotic sister chromatid cohesion 0.2795785216659322 0.0370305140865038 0.970460675696607 1.0 1.0 14 Q12834,Q8IY18,Q96MF7,Q9Y6X3 4 +Regulation of translational fidelity 0.2794759439241764 0.0368183743450937 0.9706298233721776 1.0 1.0 14 Q99543,Q86U90 2 +Cellular response to increased oxygen levels 0.2818756111504958 0.0367350400911683 0.9706962695364654 1.0 1.0 7 Q8N511 1 +Negative regulation of rna catabolic process 0.279344739147604 0.0367246213664507 0.9707045768705392 1.0 1.0 29 Q92804,Q14011,P35637 3 +Body fluid secretion 0.2777840960364305 0.0366753294636091 0.9707438796416517 1.0 1.0 13 Q15648,Q9UNS2,Q13505 3 +Connective tissue development 0.2829648885503628 0.0364327238775607 0.9709373216111918 1.0 1.0 26 Q8N0X7,Q15043,O15270,A1X283,P11802,O75844,P43490 7 +Superoxide metabolic process 0.2691612162699066 0.0363375752681812 0.9710131889813308 1.0 1.0 9 A1X283,Q05655 2 +Superoxide anion generation 0.2856202121747753 0.0357738930245851 0.9714626500864708 1.0 1.0 6 A1X283 1 +Positive regulation of lymphocyte apoptotic process 0.4579224194608728 0.0348515283136889 0.9721981319113482 1.0 1.0 2 Q07812 1 +Bone marrow development 0.4579224194608708 0.0348515283136886 0.9721981319113484 1.0 1.0 2 Q9Y3A5 1 +Activation of phospholipase d activity 0.3087800065767822 0.0344994015181656 0.9724789195848922 1.0 1.0 3 P18085,P40616 2 +Vascular associated smooth muscle cell migration 0.28125000000001 0.0342647122108986 0.9726660639125482 1.0 1.0 4 Q14344,Q04656,P61586 3 +Response to uv b 0.4520052596975613 0.0336903247769682 0.9731240943038082 1.0 1.0 2 Q01831 1 +Hormone catabolic process 0.3045050970075679 0.0332837054548766 0.9734483477241392 1.0 1.0 3 P14735,P42892 2 +Regulation of neurotransmitter levels 0.2805217021666716 0.0332530865219446 0.973472764582133 1.0 1.0 27 P21359,P41440 2 +Establishment of epithelial cell apical basal polarity 0.2847989650204918 0.0325408148522659 0.9740407677061476 1.0 1.0 5 P61586 1 +Negative regulation of response to biotic stimulus 0.2810620079631735 0.0325045068526262 0.974069721981634 1.0 1.0 17 Q14166,Q07021,Q9NX58,Q7Z739,Q92890,P19474,Q9Y3Z3,Q96J02,P04439 9 +Regulation of hippo signaling 0.4434582511505527 0.0322099094252446 0.974304653702094 1.0 1.0 2 Q01085 1 +Signal transduction in absence of ligand 0.2817174813595109 0.0321405729675544 0.974359947562388 1.0 1.0 18 P30153,P30154,P06756,P21359,P31749 5 +Myeloid cell apoptotic process 0.2842764844300284 0.0320487462916334 0.9744331769240546 1.0 1.0 5 Q96EB6,P14174 2 +Regulation of rna splicing 0.2787716816808475 0.031749976332495 0.974671439605564 1.0 1.0 83 P14866,P52756,P17844,P31942,P22626,P98179,P78362,P08621,Q06787,Q07021,P35637,P52597,Q9BWF3,Q96MU7,Q92879,Q4G0J3,P61978,Q8IY67,P51114,P55795,P62995,Q07666,P31943,P26368,O60828,Q14011,Q96PU8 27 +Spliceosomal conformational changes to generate catalytic conformation 0.4358974358974273 0.0310769286464435 0.975208189053958 1.0 1.0 2 Q9HCS7 1 +Pigment metabolic process 0.2817131264285734 0.0305711874893875 0.9756115204579874 1.0 1.0 24 P34897,P06132,P30519,Q7KZN9 4 +Negative regulation of regulated secretory pathway 0.2743421052631665 0.0301605430032735 0.9759390163266844 1.0 1.0 4 Q06787,P09601,O00186 3 +Carbohydrate homeostasis 0.2503392553400477 0.029549125859097 0.9764266392583354 1.0 1.0 39 P17612,Q15043,P62753,P08237,Q12824,O76024,Q96ST3,P40763,P22059,Q8NE86,Q15120,Q08209,P31749 13 +Cytoplasmic translational initiation 0.2816950612301912 0.0294218874246667 0.9765281167190468 1.0 1.0 21 Q9NR50,P55010,P16333,Q9BWF3,O15371,Q7L2H7,Q14152,Q9ULC4,Q15056,P42345 10 +Regulation of response to cytokine stimulus 0.2814757922511069 0.029262332681851 0.976655368193837 1.0 1.0 23 O94813,Q99829,P43034,Q7Z739,Q15648,Q9Y3Z3,Q7Z434 7 +Negative regulation of proteolysis 0.2446356716201505 0.0291651545080578 0.976732872078699 1.0 1.0 66 Q15392,P78318,Q86UE8 3 +Regulation of pigmentation 0.4191321499013721 0.0290747362282733 0.9768049848468704 1.0 1.0 2 Q07812 1 +Regulation of torc2 signaling 0.4171597633136013 0.0288798764677504 0.9769603951795618 1.0 1.0 2 Q9Y4R8 1 +Leydig cell differentiation 0.4138724523339853 0.0285721096217817 0.9772058562972924 1.0 1.0 2 Q15637 1 +Cellular carbohydrate metabolic process 0.2324346618533558 0.0283785101108789 0.977360263744968 1.0 1.0 60 P48735,Q9BYT8,Q9NUJ1,P31751,O75874,O00763,Q7LGA3 7 +Regulation of blood circulation 0.2810277594342995 0.0283268886555413 0.977401435155512 1.0 1.0 23 P17612,P15924,O75844,P14923 4 +Dendritic cell migration 0.279652768721328 0.0278608617469321 0.977773124117804 1.0 1.0 5 Q07021 1 +Ear development 0.2804017925758711 0.0278002979742296 0.9778214283065656 1.0 1.0 24 P33993,Q9Y4P1,O95487,P43034,P39210 5 +Negative regulation of lymphocyte activation 0.2762802440846288 0.0274977882996012 0.9780627038629852 1.0 1.0 15 Q92990,Q96J02,Q13951 3 +Purine containing compound biosynthetic process 0.2500405776758001 0.0274631178771052 0.9780903564145764 1.0 1.0 69 O43252,Q13126,P34897,P22392,O00763,Q9NZ01,Q15120,Q9NVE7,Q13085,Q8WVC6,P34896 11 +Regulation of synapse structure or activity 0.2717890731673531 0.0273699869146546 0.9781646362495118 1.0 1.0 31 P43034,Q9H2U1,Q9UQB8,Q00535,P61586,P60953,Q7L576,P19022 8 +Dephosphorylation of rna polymerase ii c terminal domain 0.3967784352399693 0.0272762002299255 0.9782394392698752 1.0 1.0 2 Q96P16 1 +Viral gene expression 0.2563207563747431 0.0272656119466099 0.9782478843567588 1.0 1.0 37 P55884,Q12824,P48729,P50750,Q99873,O14646,Q9ULC4 7 +Positive regulation of fc receptor mediated stimulatory signaling pathway 0.391190006574614 0.0269483397665259 0.978500937942292 1.0 1.0 2 Q06481 1 +Alpha amino acid metabolic process 0.2557833159610084 0.0269302620369082 0.9785153566506836 1.0 1.0 72 O60725,P17812,Q9NRF8,Q13126,P78330,P34897,Q96RQ3,O75600,P52788,Q13867,Q9NRN7,P34896 12 +Regulation of protein binding 0.2117916377988561 0.0266919356786141 0.9787054452385024 1.0 1.0 50 P17612,P48681,P41440,O75381,Q05655,Q00535,P60953,P62942,Q13526,P31749,Q96D46 11 +Negative regulation of nuclease activity 0.3859303090072298 0.0266762361360464 0.9787179672022628 1.0 1.0 2 O00273 1 +Smooth muscle cell differentiation 0.2749181365270047 0.0263643160747738 0.9789667558973034 1.0 1.0 7 Q53EL6,P26358 2 +Male meiosis i 0.3678500986193249 0.0259663560705238 0.9792841733638816 1.0 1.0 2 Q15645 1 +Regulation of protein import 0.279860646280222 0.0255945660776283 0.9795807202936752 1.0 1.0 22 O14737,O00410,P62826,Q9UHD1,Q05655,Q7Z434,O95071,P21359,P14923 9 +Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.3484549638395746 0.0254976024224202 0.9796580608566574 1.0 1.0 2 Q99729 1 +Convergent extension 0.332347140039446 0.0252632163379909 0.9798450136703184 1.0 1.0 2 Q13263 1 +Regulation of hydrogen peroxide biosynthetic process 0.3303747534516738 0.0252415935741229 0.9798622606398356 1.0 1.0 2 P00403 1 +Positive regulation of smooth muscle cell differentiation 0.3303747534516762 0.0252415935741229 0.9798622606398356 1.0 1.0 2 Q96EB6 1 +Positive regulation of hydrogen peroxide metabolic process 0.3303747534516738 0.0252415935741229 0.9798622606398356 1.0 1.0 2 P00403 1 +Negative regulation of meiotic cell cycle 0.3290598290598278 0.0252279019207601 0.9798731815209444 1.0 1.0 2 Q15645 1 +Regulation of axon guidance 0.2644736842105385 0.0251248045402906 0.9799554152630356 1.0 1.0 4 Q9BVA1,O14786,O94813 3 +Fat cell proliferation 0.3152531229454312 0.0251142558550545 0.979963829241132 1.0 1.0 2 Q13501 1 +Regulation of exosomal secretion 0.2634033237830977 0.025036559865893 0.9800258021846896 1.0 1.0 9 Q92783 1 +Chondrocyte differentiation involved in endochondral bone morphogenesis 0.2919132149901396 0.0250107490083859 0.9800463898225684 1.0 1.0 2 P50454 1 +Blood vessel endothelial cell migration 0.2793266987563684 0.0245169683097618 0.9804402490290838 1.0 1.0 22 Q8WTV0,O94813,P61586,P21359,P14923,P31749 6 +Positive regulation of protein sumoylation 0.2628289473684281 0.0243740273084921 0.9805542653748368 1.0 1.0 4 Q9UBE0,Q9BVP2,Q9H0E2 3 +Positive regulation of peptide secretion 0.2687624603890169 0.0241583843555008 0.9807262729066756 1.0 1.0 8 P22059,Q8NE86 2 +Focal adhesion assembly 0.2789152814163628 0.0237994578451728 0.9810125725048492 1.0 1.0 21 Q05397,Q7Z460,Q9H2G2,Q9P258,P51452,P61586 6 +Regulation of calcium ion dependent exocytosis 0.2744323790720713 0.0234837398729291 0.9812644086108172 1.0 1.0 5 Q15042,Q00535,O00186,P16615 4 +Positive regulation of small molecule metabolic process 0.2709383199625879 0.0231722302508854 0.9815128897075128 1.0 1.0 13 P31751,P31749 2 +Hydrogen peroxide catabolic process 0.2559210526315864 0.0214775950973823 0.9828646758627216 1.0 1.0 4 Q13162,P30044,P30048 3 +Pyrimidine containing compound metabolic process 0.2749249105025729 0.0212109804922298 0.9830773550876551 1.0 1.0 27 P17812,P22392,Q9H773,P42345,P34896 5 +Immune effector process 0.2556011842108942 0.0203800237600723 0.9837402192716032 1.0 1.0 73 Q05397,P62753,Q96QE3,Q07021,P22681,Q9H2U1,Q9NVJ2,Q15046,Q05655,Q9UQ84,P14174,Q7Z434,Q92538,P42345 14 +Immunoglobulin production 0.27604000597284 0.0189450357769798 0.9848849526230758 1.0 1.0 24 Q96QE3,Q9UQ84,P78527 3 +T cell proliferation 0.2754294707190613 0.0187964067651769 0.9850035203036722 1.0 1.0 25 Q92990,P62753,P17812,Q5ZPR3,Q96J02 5 +Positive regulation of histone modification 0.2460561721189392 0.0186458808604528 0.9851236015539832 1.0 1.0 39 Q12824,P26358,P50750,Q6PD62,Q9GZS3,Q9NPI1 6 +Protein neddylation 0.271231073074394 0.0186255050077835 0.9851398563094468 1.0 1.0 6 Q13564,Q92564,Q8TBC4,P46777,P62913 5 +Transforming growth factor beta production 0.2652887758197186 0.0166711625296029 0.9866989529313296 1.0 1.0 5 O75787 1 +Dephosphorylation 0.2869272735448643 0.0159158171840745 0.9873015513127188 1.0 1.0 90 Q7Z4H3,Q9UPR3,O95429,P30154,P42858,Q9H857,Q9H993,Q969T7,Q08209,Q9NPH0,Q9UPN7,P30153,P78318,Q13526,Q9NRX4,Q8IV63,P78330,Q05655,O00743,P62942,Q13555,P42345 22 +Positive regulation of sodium ion transmembrane transport 0.2685550472434939 0.0158133050977951 0.9873833338312854 1.0 1.0 6 Q9UHD1,O43707 2 +Nucleobase metabolic process 0.2746868588917467 0.0156523883764463 0.9875117109095974 1.0 1.0 21 P34897,P34896,P17812,P42345 4 +Mitotic dna replication 0.2648188719887908 0.0153425744900954 0.9877588769422968 1.0 1.0 12 P33991,Q14691,P33993,O75844 4 +Positive regulation of leukocyte chemotaxis 0.2622658424161377 0.0144472190718407 0.9884731879409144 1.0 1.0 11 Q05397,Q07021 2 +Protein localization to nuclear body 0.2617870095614897 0.0136055992072931 0.989144637363307 1.0 1.0 11 Q4G0J3,O60832,Q7L2J0,Q99832,P50991,P49368,P50990,P78371,P17987,P40227 10 +Regulation of meiotic cell cycle 0.2606120434353516 0.0135843445388651 0.989161594567975 1.0 1.0 5 P33981,Q12834,Q15645,Q9H6S0 4 +Negative regulation of reproductive process 0.260612043435351 0.0135843445388649 0.9891615945679753 1.0 1.0 5 Q13162,P33981,Q15645,P35579 4 +Intrinsic apoptotic signaling pathway 0.2608799949909965 0.0130594021094049 0.9895804008580348 1.0 1.0 77 Q96QE3,P61978,O95831,Q96RU2,P16333,Q05655,Q96K76,Q2TAL8,O95881,O00571,P14174,P78527,P52701,Q9P0J0,P31749,Q15233,P31689 17 +Rna methylation 0.2729690671951447 0.0124769307354388 0.9900451078866384 1.0 1.0 23 Q13395,Q4G0J3,Q96P11,Q8N1G2,P57081,Q9NNW5 6 +Tricarboxylic acid cycle 0.2729043066056177 0.0121760900633764 0.9902851257780384 1.0 1.0 22 P50213,P48735 2 +Response to oxygen radical 0.2560052648897725 0.0107917127128827 0.9913896261709771 1.0 1.0 5 P04179,Q04656,Q9NX46,P00374 4 +Cellular response to oxygen radical 0.2560052648897725 0.0107917127128827 0.9913896261709771 1.0 1.0 5 P04179,Q04656,Q9NX46,P00374 4 +Lung morphogenesis 0.2553559677457412 0.0105549845750441 0.9915784971383934 1.0 1.0 9 O95487 1 +Regulation of mirna transcription 0.2629899636725345 0.0103265966395441 0.9917607144135734 1.0 1.0 6 P40763 1 +Developmental cell growth 0.2175729944189042 0.0099242750349786 0.9920817041530988 1.0 1.0 45 O95376,Q96F07,Q8N0X7,Q96ST3,Q99829,P43034,Q96PU5,Q00535,Q7L576 9 +Regulation of mrna processing 0.2674916847582431 0.0099039236725217 0.9920979413930004 1.0 1.0 81 P14866,P52756,P17844,P22626,Q96ST2,P98179,P78362,P08621,Q06787,Q07021,Q9H2U1,P50750,Q9BWF3,Q96MU7,Q92879,Q4G0J3,P61978,Q8IY67,P51114,Q07666,O43809,O43865,P26368,Q6PD62,Q14011,Q96PU8 26 +Epidermal cell differentiation 0.265171458827588 0.0096730791907239 0.9922821198168474 1.0 1.0 30 P15924,O95487,P43034,P18074,P22392,Q12948,P19447,Q99816 8 +Wound healing 0.2340627090177479 0.0094112277518838 0.9924910375250486 1.0 1.0 64 Q05397,Q8WTV0,P20248,Q16625,P15924,Q05655,Q9NVJ2,P61586,Q99439,P21359,Q08209,Q9Y251,P42345 13 +Rab protein signal transduction 0.2523258262475827 0.0087302415399122 0.9930343635467918 1.0 1.0 5 Q15286 1 +Actin filament bundle organization 0.2217511027905437 0.0086864569193705 0.9930692972948882 1.0 1.0 44 Q9UQB8,O95429,P42345 3 +Positive regulation of cell population proliferation 0.3433600608818775 0.0084387120072738 0.9932669618884576 1.0 1.0 122 O43663,O60884,P24941,Q96Q89,Q86X55,Q5ZPR3,Q9BSK2,Q99873,P43490,Q7Z5K2,P78362,P07384,P07942,P26358,P31751,P21359,Q9ULC4,Q05397,P20248,P11802,P62701,Q13418,Q15648,P60953,P55209,P22392,P14174,Q9H2J4,P31749,O95684,P48681,Q12834,Q96QE3,P62753,P06756,P40763,Q9Y251 37 +Tail anchored membrane protein insertion into er membrane 0.2534542201306571 0.0073535324426649 0.9941327828744284 1.0 1.0 9 Q7L5D6,Q15006 2 +Dna strand elongation 0.2698986613349627 0.0067893743200178 0.994582904669958 1.0 1.0 22 P33993,Q07864,P49005,Q14691,Q9NRF9,P33991,P40938 7 +Digestive system process 0.2577338968020126 0.0066979681636547 0.994655834572518 1.0 1.0 11 Q8WTV0,Q9UDY2,P11171,P21399,P53621 5 +Negative regulation of dna repair 0.2596819791712018 0.0065145564340717 0.9948021727662856 1.0 1.0 12 Q96FW1 1 +Positive regulation of chromosome condensation 0.2478530241358316 0.0064170599198404 0.9948799621036182 1.0 1.0 5 Q15003,Q15021 2 +Regulation of fat cell differentiation 0.2613028266217685 0.0060993334442832 0.9951334661876616 1.0 1.0 13 P31749,Q86X55 2 +Sodium ion transport 0.2690362109960236 0.005517402038434 0.9955977724330364 1.0 1.0 21 Q9UHD1,Q96PU5,O43865,P46939,Q96QD8,O43707,Q8N335,P31749 8 +Positive regulation of calcium ion transport 0.2608928091338173 0.0054221441339555 0.995673776107322 1.0 1.0 13 Q00535,P27695,P42858 3 +Regulation of endoplasmic reticulum unfolded protein response 0.2520593080724995 0.0050583536806149 0.9959640349064984 1.0 1.0 9 Q07812,O76024,P16333,Q92905,P63244,O94874,P18031,P57088 8 +Response to increased oxygen levels 0.2519627268382297 0.0049010948813473 0.9960895077186298 1.0 1.0 9 Q8N511 1 +Negative regulation of transport 0.2517625057913651 0.0041844533025578 0.9966612990577386 1.0 1.0 74 Q9HD26,O95429,Q96PU5,P31751,P21359,Q16850 6 +Energy reserve metabolic process 0.2649421117313371 0.0028696462533904 0.99771035670194 1.0 1.0 17 P31751,P31749,P42345 3 +Import into nucleus 0.2335346648973763 0.0026803601036688 0.9978613846166442 1.0 1.0 65 O00505,P62826,Q9UHD1,O95071,O15397,Q08209,O00410,Q13148,Q92973,Q9UI26,Q96P70,P21359,O60684,Q15648,P37198,Q7Z434,Q5SRE5,P55060,P31749,P14923,Q9Y5L0,P40763,Q05655,P49815 24 +Dna packaging 0.2642748204753833 0.0014513770284104 0.9988419690836918 1.0 1.0 81 Q9H7B4,Q14997,Q7Z5K2,P33993,O95831,Q96ST3,P26358,Q99733,Q6PD62,P55209,Q9NRF9,P10412,Q8IY18,Q01105 14 +Activation of innate immune response 0.2665728873056083 0.0013639194301773 0.99891175008189 1.0 1.0 21 Q96ST3,P12956,O60828,Q7Z434,Q9NUD5,P78527,Q15233 7 +Anion transport 0.24282178401345 0.0012820422965132 0.9989770785255336 1.0 1.0 70 Q9HD26,Q9H813,P41440,O43865,Q9UHG3,Q6N075,Q9H2D1,Q96NB2,O75746,O43808,P14174,Q7L0J3,P21359,P0CG08 14 +Regulation of cellular response to transforming growth factor beta stimulus 0.2611273270390049 0.0006441586973795 0.999486035756198 1.0 1.0 15 Q9Y3F4,Q9UPN9,Q9GZN8,P62942,Q13526 5 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3abd60c54a6f8184496d0827e95e1daf45c40297 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in blood vessel morphogenesis", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Atrioventricular valve development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Bronchus development", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cocaine", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to progesterone stimulus", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondroblast differentiation", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorio allantoic fusion", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalamin transport", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna cytosine deamination", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Elastic fiber assembly", "Elastin metabolic process", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eye pigmentation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat pad development", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated inhibitory signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart field specification", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Heparin metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response inhibiting cell surface receptor signaling pathway", "Immune response inhibiting signal transduction", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological memory formation process", "Immunological memory process", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Inositol trisphosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 17 production", "Interleukin 18 mediated signaling pathway", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion import across plasma membrane", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein particle remodeling", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell proliferation", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microtubule severing", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte activation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of atpase coupled calcium transmembrane transporter activity", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone mineralization", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cardiocyte differentiation", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of complement activation", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of g0 to g1 transition", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of humoral immune response", "Negative regulation of humoral immune response mediated by circulating immunoglobulin", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 1 beta production", "Negative regulation of interleukin 1 mediated signaling pathway", "Negative regulation of interleukin 1 production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein metabolic process", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage activation", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage derived foam cell differentiation", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microglial cell activation", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuroinflammatory response", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor recycling", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor 2 signaling pathway", "Negative regulation of toll like receptor 4 signaling pathway", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of triglyceride catabolic process", "Negative regulation of triglyceride metabolic process", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron fate specification", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron neuron synaptic transmission", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nitrogen utilization", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Nodal signaling pathway", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Noradrenergic neuron development", "Noradrenergic neuron differentiation", "Norepinephrine metabolic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otic vesicle development", "Otic vesicle formation", "Otic vesicle morphogenesis", "Otolith development", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet derived growth factor receptor alpha signaling pathway", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic dna fragmentation", "Positive regulation of apoptotic process involved in development", "Positive regulation of apoptotic process involved in morphogenesis", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagosome maturation", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental pigmentation", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna catabolic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of enamel mineralization", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage derived foam cell differentiation", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of memory t cell differentiation", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide mediated signal transduction", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoblast proliferation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phospholipid translocation", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of regulatory t cell differentiation", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tooth mineralization", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of transforming growth factor beta production", "Positive regulation of transforming growth factor beta1 production", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic animal organ morphogenesis", "Post embryonic camera type eye development", "Post embryonic development", "Post embryonic eye morphogenesis", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Preassembly of gpi anchor in er membrane", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked deubiquitination", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside catabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of angiotensin levels in blood", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte activation", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement activation classical pathway", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of defense response", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of enamel mineralization", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homophilic cell adhesion", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of humoral immune response mediated by circulating immunoglobulin", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of iron ion transmembrane transport", "Regulation of iron ion transport", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage derived foam cell differentiation", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell division", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by circulatory renin angiotensin", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 2 signaling pathway", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tooth mineralization", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoprotein", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 18", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to luteinizing hormone", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to staurosporine", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cell programmed cell death", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 3 uridylation", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Rostrocaudal neural tube patterning", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary heart field specification", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of extracellular ligand from receptor", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal complex assembly", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Smoothened signaling pathway involved in ventral spinal cord patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spinal cord patterning", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfation", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Tolerance induction to self antigen", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type b pancreatic cell proliferation", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent glycoprotein erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Ureter morphogenesis", "Ureteric bud elongation", "Urogenital system development", "Uronic acid metabolic process", "Uterine smooth muscle contraction", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Vagina development", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APOB", "APOBEC3C", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRIX1", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C17orf75", "C19orf70", "C1QBP", "C20orf27", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALM3", "CALR", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC25", "CCDC47", "CCDC6", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPI", "CENPV", "CEP290", "CEP44", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "CNP", "CNPY2", "COA3", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM83D", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHITM", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLM1", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRS4", "ISCU", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZTFL1", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL28", "MRPL3", "MRPL37", "MRPL43", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM165", "TMEM167A", "TMEM199", "TMEM201", "TMEM206", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM43", "TMEM59", "TMEM87A", "TMEM9", "TMEM97", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSR1", "TSR2", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR73", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZDHHC13", "ZFYVE16", "ZMPSTE24", 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"DYNLL1", "EARS2", "ECE1", "EDC3", "EDC4", "EEF1E1", "EHD1", "EIF2AK2", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3H", "EIF3M", "EIF4H", "EIF5", "ELAC2", "ELOA", "ELOC", "EMC2", "EML4", "ENAH", "EPB41", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERMP1", "ERO1A", "EXO1", "EXOC4", "EXOC7", "FAF1", "FAM49B", "FAM91A1", "FAM98A", "FAR1", "FARSA", "FARSB", "FASN", "FEN1", "FERMT2", "FGFR1OP", "FHL1", "FKBP14", "FKBP1A", "FKBP2", "FKBP4", "FKBP7", "FKBP9", "FKRP", "FLII", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FUS", "FXR1", "GALNT2", "GBF1", "GCAT", "GDI2", "GEMIN4", "GET4", "GFPT1", "GHITM", "GINS1", "GINS2", "GINS4", "GLMN", "GLRX5", "GNA13", "GNL3", "GOLGB1", "GOLPH3L", "GOPC", "GPD1L", "GPR107", "GPR89B", "GSTA4", "GSTM3", "GTF2E1", "GTF3C1", "GTF3C3", "GTPBP4", "HADH", "HDDC2", "HDGFL2", "HELLS", "HELZ", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMGB1", "HMGB2", "HMOX1", "HMOX2", 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0000000000000000000000000000000000000000..ad858244b2fc7ac7e9bbf17da29c94262d941139 --- /dev/null +++ b/msigdb_gocc/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:71d0e0391b405e6c77072d12da7863048c41b92d8d89027b30d3b2129cfbfbe5 +size 84469 diff --git a/msigdb_gocc/df_merge.tsv b/msigdb_gocc/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..50a3396b2325fe5e94a3eda8371e7c4f376e3313 --- /dev/null +++ b/msigdb_gocc/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome core complex beta subunit complex 3 7 2.4950966221000086 0.0125922836245955 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 9.130642966886304e-06 6.123874455167476e-05 3.1648689494321087e-05 0.0004978290871657 +Postsynaptic specialization intracellular component 0 5 2.2270429985314597 0.0259444002005539 0.9368932038834952 4.580097087378641 1.0243451866343556 0.3526172805798264 1.2251007718616247 0.7111401963913695 0.8141106380508738 0.2958370422450036 1.0 0.0385773062479974 0.0714416582380786 0.1702318601155425 0.3190458812596383 +Proteasome core complex 7 14 2.1179158275973347 0.034182196912375 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 1.0 7.189730386960826e-05 0.0004698914927371 0.0005168566519776 8.180430587459396e-05 +Proteasome complex 11 44 2.007504928029423 0.0446959264352304 14.026699029126211 46.786407766990294 0.4420598252615278 0.5373615775614314 7.719082757566109 2.020047511874643 1.333666971110317 0.369590668247101 1.0 0.0023085518548632 0.0015062975318159 0.0078689504463762 0.0034206680068197 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7b0a1244a9f2d567f580026826a152536105cbe5 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 901, + "title": "Average number of proteins per term", + "value": 28.110987791342954 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5545618e7418afed34eac1640ddc3f3d65de35ed --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1c000a2d541fad1a269441817ae105813056c520 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,230 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome core complex beta subunit complex 0.8792083465608126 2.4950966221000086 0.0125922836245955 0.9999890007860772 0.9376191458898886 7 P28074,P28070,P49721 3 +Proteasome core complex 0.7254770875866369 2.1179158275973347 0.034182196912375 0.9999999999999756 0.9376191458898886 14 P25786,P28070,P49721,Q99436,P20618,P28074,P60900 7 +Proteasome complex 0.4889209497145089 2.007504928029423 0.0446959264352304 1.0 1.0 44 P25786,Q14997,O00231,P28070,Q15386,Q5VYK3,P49721,Q99436,P28074,P20618,P60900 11 +Ciliary base 0.773902516472736 1.909136447620572 0.0562444920216345 1.0 1.0 6 A0AVF1 1 +Fascia adherens 0.7653217011282041 1.8717666218716869 0.0612388979521965 1.0 1.0 6 P15924,P14923 2 +Polysome 0.4576410103004698 1.8371097177654656 0.0661936998668863 1.0 1.0 45 P62910,Q7Z417,P25786,Q02543,Q9HAU5,P62753,P62917,Q9Y3U8,Q06787,P62701,P62266,P51114,Q92616,P60900,O15372,P83881,P84098,P83731 18 +Excitatory synapse 0.810082407884529 1.7610693854817168 0.0782266599127678 1.0 1.0 4 Q7L576,Q9UQB8 2 +Scf ubiquitin ligase complex 0.7396010705162733 1.758993437149286 0.0785786232785006 1.0 1.0 6 P63208 1 +Cornified envelope 0.6839550431015057 1.7571662240320334 0.0788894805246402 1.0 1.0 8 P15924,P14923,Q14574 3 +Magnesium dependent protein serine threonine phosphatase complex 0.7092187092431218 1.7472882756624402 0.0805873457836874 1.0 1.0 7 Q08209,P30153,P30154 3 +Postsynaptic cytosol 0.7304400778657524 1.7185641313332554 0.0856937675885065 1.0 1.0 6 Q13526,Q9UQB8 2 +Core mediator complex 0.7601184600197344 1.6987672380996812 0.089363048841941 1.0 1.0 5 Q15648,Q9NVC6,O75448,Q9NPJ6 4 +Desmosome 0.6701891922728349 1.6918357774029154 0.0906772899141352 1.0 1.0 8 P15924,P14923,Q14574 3 +Dna replication factor c complex 0.7145016513753613 1.6479177916194738 0.099369541938507 1.0 1.0 6 P40937,P40938,P41440 3 +Ciliary transition zone 0.6856512509625257 1.6391450560611784 0.1011830534220807 1.0 1.0 7 Q15555,P41208,A6NIH7 3 +Postsynaptic density membrane 0.708721514821212 1.6222062750134234 0.1047591885646781 1.0 1.0 6 Q14168,Q15334,P57105,Q99720 4 +Mediator complex 0.6153133646469595 1.5487227431902126 0.1214483842081113 1.0 1.0 10 P11802,O75448,P50750,Q93074,Q15648,Q9NPJ6,Q9NVC6 7 +Protein phosphatase type 2a complex 0.7226780573293863 1.538080007313028 0.1240290536778312 1.0 1.0 5 P30153,P30154 2 +Cop9 signalosome 0.6338435564157547 1.517704877822583 0.1290888138536714 1.0 1.0 8 Q9UNS2,Q7L5N1,Q99627 3 +Ciliary basal body 0.6020695553559539 1.5004230069952165 0.1335048635985209 1.0 1.0 16 Q05397,P28070,P41208,P48729,A0AVF1,Q15154,Q9UPT5,Q13526,P31749 9 +Endopeptidase complex 0.3965227862762827 1.4680042213373532 0.142103076255847 1.0 1.0 53 P28070,Q92643,Q15386,P49721,P28074 5 +Intrinsic component of golgi membrane 0.5985242589778649 1.4670017137914988 0.1423755891420888 1.0 1.0 9 Q9Y282,O95070 2 +Origin recognition complex 0.6728349008595076 1.4616210520009851 0.1438450822115118 1.0 1.0 6 Q9UFC0,Q9UBD5,P33993,O43913 4 +Dynactin complex 0.7043843849783724 1.459036637389438 0.1445550240866193 1.0 1.0 5 Q9NZ32,Q9UJW0 2 +Dendritic shaft 0.7038490098261431 1.4567191727932247 0.1451939151287411 1.0 1.0 5 Q9UQB8,Q96J84 2 +Cytosolic region 0.6446625318579451 1.4490565948492191 0.1473217782292608 1.0 1.0 7 Q13526,Q9UQB8 2 +Ciliary tip 0.7334715221652071 1.4437871118714547 0.1487988684316592 1.0 1.0 4 A0AVF1 1 +Integral component of synaptic vesicle membrane 0.6667635945935322 1.4343139342200266 0.1514826956644928 1.0 1.0 6 Q7L0J3,O60499,O76024 3 +Postsynaptic specialization membrane 0.5892479672774773 1.416928549283945 0.1565038185619069 1.0 1.0 10 Q14168,P57105,Q99720,P19022 4 +Cyclin dependent protein kinase holoenzyme complex 0.588442012975682 1.4123566089390005 0.1578449859287105 1.0 1.0 13 P20248,P24941,P11802,P50750,O95067 5 +Escrt i complex 0.8329496876027549 1.3953021806936812 0.1629247347594247 1.0 1.0 3 Q9H9H4,Q96EY5 2 +Ctf18 rfc like complex 0.7216465409698123 1.394410921118458 0.1631935520670624 1.0 1.0 4 P40937 1 +Smn complex 0.6840356109008525 1.3708193087401164 0.1704312902378131 1.0 1.0 5 Q8TEQ6,Q16637,P57678 3 +Eukaryotic translation initiation factor 2b complex 0.6461676893955458 1.3414574871955731 0.1797719636884753 1.0 1.0 6 Q9UI10,Q13144,Q9NR50,P49770 4 +Presynaptic cytosol 0.7062346893563818 1.3299820485959486 0.1835241859895566 1.0 1.0 4 Q9UQB8 1 +Cis golgi network 0.5672538236626116 1.301783723981036 0.1929903292229 1.0 1.0 13 O00461,Q92538,Q9UNK9,O43731 4 +Torc1 complex 0.8053720263279183 1.2904271266586191 0.1969023986573488 1.0 1.0 3 P42345 1 +Tor complex 0.8053720263279183 1.2904271266586191 0.1969023986573488 1.0 1.0 3 P42345 1 +Mitotic spindle microtubule 0.6003765758046812 1.2417066774246164 0.2143448053772336 1.0 1.0 7 Q00610,Q7Z4H7,Q68CZ6 3 +Gemini of coiled bodies 0.6788826265800615 1.215598770106996 0.2241378029031775 1.0 1.0 4 Q16637,P57678 2 +Transcription factor tfiid complex 0.6178183111918456 1.213308448317754 0.22501191408045 1.0 1.0 6 Q9Y6J9,P18074,P29083 3 +Haus complex 0.6415802486714413 1.1863291858290583 0.2354923250795551 1.0 1.0 5 Q7Z4H7,Q68CZ6 2 +Nonhomologous end joining complex 0.7761066180381226 1.1793612585951758 0.2382543548721152 1.0 1.0 3 P78527 1 +Contractile ring 0.6371287140943069 1.1669960536058075 0.2432119632590696 1.0 1.0 5 O43663,Q96Q89,P46939 3 +Carboxy terminal domain protein kinase complex 0.6071302558972953 1.1649802672442633 0.2440269804166135 1.0 1.0 6 P18074,P50750 2 +Intrinsic component of synaptic vesicle membrane 0.5359886267827799 1.145333228536052 0.2520711463042113 1.0 1.0 10 O76024,O60499,O15126,Q15286,Q7L0J3 5 +Cytosolic large ribosomal subunit 0.3718434685903559 1.1402884605172243 0.2541661437392053 1.0 1.0 46 P62910,P61313,P61927,P46776,P35268,P18077,P36578,P84098,Q02543,P27635,P46778,P18124,P83881,P62917,P18621,P39023,Q07020,Q9Y3U8,P83731 19 +Paraspeckles 0.5999173491720726 1.1323857884059174 0.2574722770393827 1.0 1.0 6 Q15233,O43809,Q8WXF1,P23246 4 +Proteasome core complex alpha subunit complex 0.5762767645209298 1.1285825747528846 0.2590739648902185 1.0 1.0 7 P25786,P60900 2 +Rna polymerase ii transcription regulator complex 0.4954176817799551 1.1274982287506063 0.2595318889710856 1.0 1.0 29 Q9Y4A5,Q15233,P40763,P42224,O75448,Q9NPJ6,Q15648,Q13951,P18074,P19447,Q8TEQ6,Q9Y6J9,Q9NVC6,Q9Y2X0,Q96T76,P29083 16 +Nurd complex 0.5533910868117685 1.126649905936976 0.2598905299820133 1.0 1.0 8 O94776,Q12873 2 +Transcription factor tfiih holo complex 0.760276224926003 1.1195175434260158 0.2629194108549275 1.0 1.0 3 P18074,P19447 2 +Endoplasmic reticulum tubular network 0.530081678498979 1.1083399852993 0.2677150130303269 1.0 1.0 12 Q6DD88,Q9H6H4 2 +Intrinsic component of postsynaptic specialization membrane 0.7546859585662535 1.098442538397182 0.2720112960370318 1.0 1.0 3 Q15334,P19022 2 +Mitotic spindle midzone 0.566844998733516 1.0843620222208024 0.2782043155206253 1.0 1.0 7 Q86Y91,O43663,Q96Q89 3 +Escrt complex 0.5177283965914135 1.0581881120171464 0.2899696899450235 1.0 1.0 9 Q92783,Q9H9H4,Q96EY5 3 +Ap 3 adaptor complex 0.7433683779888759 1.0558898554252114 0.2910185393920286 1.0 1.0 3 Q92572 1 +Filopodium tip 0.6392629702411536 1.050556707448078 0.29346223335873 1.0 1.0 4 Q06787,Q7L576 2 +Vacuolar proton transporting v type atpase v0 domain 0.6373634180896404 1.0426847596440871 0.2970943186469519 1.0 1.0 4 Q93050,Q9Y487 2 +Proton transporting v type atpase v0 domain 0.6373634180896404 1.0426847596440871 0.2970943186469519 1.0 1.0 4 Q93050,Q9Y487 2 +Peptidase complex 0.3692046295617761 1.0278404983209026 0.3040248625708823 1.0 1.0 60 P25786,Q14997,Q9Y6J9,O00231,P28070,Q92643,Q15386,Q5VYK3,P49721,Q99436,P28074,P20618,Q9H490,P60900,Q9Y4A5 15 +Triglyceride rich plasma lipoprotein particle 0.6321863672479358 1.021257553835849 0.3071324308578438 1.0 1.0 4 Q9UHG3 1 +Neuron to neuron synapse 0.3738000442130505 1.003885666138894 0.3154337263231046 1.0 1.0 63 Q9HD26,P57105,P62917,Q9UQB8,O43815,Q99720,P55795,P49815,Q14168,P51991 10 +Bleb 0.7280499835580286 0.998586780955976 0.3179949063957701 1.0 1.0 3 Q9BRK5,Q9Y613 2 +Dendrite membrane 0.7277787459219519 0.9975756126519704 0.3184851916079558 1.0 1.0 3 Q14168 1 +Schaffer collateral ca1 synapse 0.506825577024585 0.9863887122894645 0.3239424020001293 1.0 1.0 15 Q9UQB8,Q00535,Q16352,P35080,Q08209 5 +Cilium 0.4003935150776219 0.972336044795394 0.3308833975272054 1.0 1.0 76 P04350,Q9Y5Y2,A6NIH7,P22681,Q15154,P17612,P28070,P41208,P48729,P43034,Q8IUD2,P21266,Q9UPT5,P61026,Q13526,Q9NUQ9,P36404,O43924,Q05397,P31749,Q5SW79,A0AVF1,Q15555 23 +Centriole 0.4858174540502886 0.9356076312796288 0.3494752439920097 1.0 1.0 23 O95684,Q9Y6A4,P62826,Q9Y5Y2,P41208,P42858,Q9P287,Q15154,Q96CW5,P53350,P27695,Q5SW79 12 +Catenin complex 0.5541796592009418 0.9268767573752852 0.3539905261653371 1.0 1.0 6 P19022,P14923 2 +Protein lipid complex 0.553127323799927 0.9221883490292466 0.3564303392857542 1.0 1.0 6 Q9UHG3 1 +Microbody membrane 0.4801001951717366 0.9182522440227469 0.3584868228338598 1.0 1.0 24 Q15067,O43808,O14678,Q7Z434,P39210 5 +Transcription regulator complex 0.3762878154622063 0.9175981283905068 0.3588292981085283 1.0 1.0 68 P24941,Q13951,P19447,Q9Y5Q9,P27695,P29083,P78527,Q9Y6J9,Q9NVC6,Q8IUF8,O75629,Q12873,P11802,O75448,Q15648,P18074,Q8TEQ6,Q96T76,Q9BXJ9,Q9Y2X0,Q15233,Q9Y4A5,Q96ST3,P40763,P42224,O94776,P12956,Q9NPJ6 28 +U5 snrnp 0.4900090249496459 0.9056416701541108 0.3651255454207995 1.0 1.0 11 O95400 1 +Mmxd complex 0.7022155470095532 0.9029374322854564 0.3665591026368604 1.0 1.0 3 P18074 1 +Ap type membrane coat adaptor complex 0.4875428790407317 0.8987772167381144 0.3687713379075692 1.0 1.0 10 Q92572,Q96CW1 2 +Cul2 ring ubiquitin ligase complex 0.596632619357692 0.8755167756679867 0.3812927864733584 1.0 1.0 4 Q92990 1 +Exocyst 0.5961339513878868 0.8734946656450923 0.3823935125278108 1.0 1.0 4 Q9UPT5,Q96A65 2 +Dna replication preinitiation complex 0.4840523191384974 0.870998978031189 0.3837547110992629 1.0 1.0 12 Q9UBD5,Q14691,Q9BRT9,Q9Y248 4 +Proteasome regulatory particle lid subcomplex 0.5388413429888064 0.8588130800119343 0.3904436500020538 1.0 1.0 6 Q9UNM6,O00231,O43242,O00232,O00487 5 +Flotillin complex 0.5176394291670003 0.8555789291348271 0.3922307290140994 1.0 1.0 7 P41440 1 +Cytoplasmic stress granule 0.372886990711791 0.8408857647682584 0.4004119339583294 1.0 1.0 42 Q7Z417,P61978,Q13148,Q06787,Q9H2U1,Q9BWF3,Q14157,Q7Z739,O60828,O00571,Q92879,Q14011,Q9Y520,Q9HCE1 14 +Kinesin complex 0.4781549408585069 0.8377640655802017 0.4021632242676682 1.0 1.0 13 Q86Y91,Q96Q89,Q9BW19,Q02241,O60333 5 +Juxtaparanode region of axon 0.6842207545466304 0.8372670824387409 0.4024424578323062 1.0 1.0 3 Q14168 1 +Polysomal ribosome 0.4628670287477344 0.8347953023333881 0.4038329712926849 1.0 1.0 25 P62910,Q7Z417,Q02543,P62917,Q9Y3U8,P62266,O15372,P83881,P84098,P83731 10 +Neuron spine 0.441559163097272 0.8153792046448232 0.4148552839832129 1.0 1.0 30 P17612,Q05397,Q06787,Q9UQB8,P61586,O43815,P60953,Q7L576,Q15334,O75787,Q14168,Q08209,P27695 13 +Organelle membrane contact site 0.4730465988280358 0.8091773690383245 0.4184131303487257 1.0 1.0 15 Q96TC7,O95772,Q14849 3 +Death inducing signaling complex 0.5759942188827756 0.7924953295917242 0.42807191393686 1.0 1.0 4 Q13546,P49327 2 +Prespliceosome 0.4625335870649517 0.7812325621257918 0.4346657255235557 1.0 1.0 9 P26368,P08621 2 +Mitochondrial tricarboxylic acid cycle enzyme complex 0.5011039202775996 0.7800468043276834 0.4353633261762439 1.0 1.0 7 P50213 1 +Beta catenin destruction complex 0.5443313123123305 0.7704188000620296 0.4410515049406842 1.0 1.0 5 P48729 1 +Protein dna complex 0.3324662178459321 0.7673703015259361 0.4428613808057657 1.0 1.0 56 Q9Y4A5,Q8NB78,P33993,Q9BRT9,Q9Y248,Q14181,P12956,Q14691,Q9UBD5,P19447,P78527,P10412,P14923,P29083 14 +Microtubule associated complex 0.3302076967065944 0.7561367719327535 0.4495671969749424 1.0 1.0 46 Q9NZ32,O75935,Q86Y91,Q9UJW0,P43034,Q96Q89,Q9BW19,P49356,Q15555,Q02241,O60333 11 +Annulate lamellae 0.5653442143517896 0.7502678244712436 0.4530934170079319 1.0 1.0 4 Q9Y5L0 1 +Protein kinase complex 0.4271696344016888 0.7262664044138077 0.4676754704812089 1.0 1.0 30 P24941,P20248,P11802,P50750,Q8IUD2,P18074,P12956,P19447,P46020,P78527,O95067 11 +Neuronal ribonucleoprotein granule 0.653074646497848 0.7260702668538993 0.4677956954430882 1.0 1.0 3 Q06787,O60828 2 +Transcription preinitiation complex 0.8671926364234188 0.7229441866314701 0.4697141750246711 1.0 1.0 2 P29083 1 +Elongin complex 0.6512765212799785 0.7197643505590208 0.4716700978212564 1.0 1.0 3 Q14241 1 +Smn sm protein complex 0.4498136097383467 0.7187761026596589 0.4722788841649812 1.0 1.0 9 P57678,Q16637,Q8TEQ6 3 +Photoreceptor connecting cilium 0.5297875008091891 0.7105317115464175 0.4773744731587612 1.0 1.0 5 Q15555,P41208 2 +Proton transporting v type atpase complex 0.451046628469668 0.7100785992935563 0.4776553965013117 1.0 1.0 11 Q8N511,Q93050,Q9Y487,O75787 4 +Copi vesicle coat 0.4453773864559558 0.6971827437876665 0.4856884367604017 1.0 1.0 9 O14579,P53621,P61923,P35606,Q9Y678 5 +Growth cone membrane 0.8579881656804831 0.6943890836691697 0.4874382377604944 1.0 1.0 2 Q96A65 1 +Ribonuclease p complex 0.524211546464089 0.6878396510077444 0.4915537635864098 1.0 1.0 5 Q99575 1 +Nucleotide excision repair complex 0.478906584357291 0.6804460565828044 0.496222067045202 1.0 1.0 7 P19447,P18887 2 +Dna repair complex 0.4445980018557459 0.6765414823267196 0.4986969179630038 1.0 1.0 20 P41208,P54277,P12956,P19447,P18887,P78527 6 +Apicolateral plasma membrane 0.4962432245083069 0.674088927583204 0.5002547785037548 1.0 1.0 6 Q16625,P14923 2 +Neuron projection membrane 0.4773181674101493 0.673415164201617 0.5006832039395435 1.0 1.0 7 Q14168 1 +Mcm complex 0.4940761836556607 0.6649188241728067 0.5061024149739874 1.0 1.0 6 P33991,P33993 2 +Brush border membrane 0.4563136641438305 0.6620561369593343 0.5079352453152342 1.0 1.0 8 P41440 1 +Hemidesmosome 0.6313712594541068 0.6509380257139031 0.5150864936240795 1.0 1.0 3 P58107,P14923 2 +Clathrin coat of endocytic vesicle 0.5383821583519968 0.6457299752593373 0.5184542444030757 1.0 1.0 4 Q96CW1 1 +Spectrin associated cytoskeleton 0.627783908525555 0.6387403784563025 0.5229918402052081 1.0 1.0 3 P11171 1 +Saga type complex 0.4878233373941292 0.6386125844010044 0.5230749925868698 1.0 1.0 6 Q9Y4A5,Q9NRF9 2 +Mhc protein complex 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 1.0 3 P10321,P04439 2 +Mhc class i protein complex 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 1.0 3 P10321,P04439 2 +Mismatch repair complex 0.5142515548939852 0.5557765570839327 0.5783636133466881 1.0 1.0 4 P54277 1 +Anchored component of membrane 0.4326462882633842 0.5550244176826792 0.5788779589714206 1.0 1.0 8 Q15286,Q15334,Q9ULX3 3 +9plus0 non motile cilium 0.4164090739712688 0.5507364652455965 0.5818143434511425 1.0 1.0 10 Q15019,Q15555,Q9NX58,P41208 4 +Cyclin a2 cdk2 complex 0.8090072320841539 0.5488442263929855 0.583112356325957 1.0 1.0 2 P24941 1 +Rna polymerase iii complex 0.487220343657983 0.5420235630495169 0.5878022736325157 1.0 1.0 5 O14802 1 +Ciliary plasm 0.4184328303975755 0.5416713111203405 0.5880449566042913 1.0 1.0 13 P17612,Q15555 2 +Neuron projection cytoplasm 0.387373326435273 0.5351405934300589 0.5925526417242035 1.0 1.0 32 Q9NZ32,Q06787,P43034,Q9UQB8,Q9NVJ2,O14617,Q92572,Q15334,O60828,Q14168,P27695,O60333 12 +Pole plasm 0.4831126161114575 0.5264298126464407 0.5985896063466503 1.0 1.0 5 O00571,Q9HCE1 2 +Aminoacyl trna synthetase multienzyme complex 0.4116802606980968 0.5213653044942057 0.6021123163187896 1.0 1.0 11 Q15046,O43324 2 +Myosin complex 0.4037284433329473 0.5010266729936671 0.6163523511697246 1.0 1.0 9 O43795,P60660 2 +Cul4 ring e3 ubiquitin ligase complex 0.4527477496897493 0.4960885010583068 0.6198319717500338 1.0 1.0 6 Q92990,Q9Y4B6 2 +Smc5 smc6 complex 0.5840023761675708 0.4960124528151519 0.6198856250795228 1.0 1.0 3 Q8IY18 1 +Cytoplasmic dynein complex 0.4340197309240474 0.4884832068740306 0.6252076177259402 1.0 1.0 7 Q9UJW0 1 +Cytoplasmic region 0.3051245544066837 0.4852664455905802 0.6274873541002868 1.0 1.0 58 P17612,P04350,Q7Z460,Q9NZ32,Q06787,P43034,Q9UQB8,Q9NVJ2,Q8IUD2,O14617,Q92572,Q15019,Q15334,O60828,Q14168,Q15555,P27695,O60333 18 +Vesicle tethering complex 0.4044243071344085 0.4674165718475225 0.6402018684419593 1.0 1.0 16 Q96A65,Q6NUQ1,Q9UPT5,Q7Z392 4 +Myosin ii complex 0.4836962019387694 0.4482241813544738 0.6539914126630271 1.0 1.0 4 P60660 1 +Pml body 0.388783024210089 0.4288236050490323 0.6680515991545113 1.0 1.0 25 Q9ULX6,Q96EB6,Q12873,P50750,P60228,Q13137,Q92547,Q93009,P27694,Q9UBW7,Q8IY18,Q96MF7,P42345 13 +Messenger ribonucleoprotein complex 0.4773615560221304 0.4269808725919537 0.6693932594451275 1.0 1.0 4 P51991 1 +Adherens junction 0.2892999630100085 0.4150691762941068 0.6780912632123888 1.0 1.0 46 Q15417,Q53GG5,P41440,Q9UQB8,P19022,P61026,P14923 7 +Intrinsic component of postsynaptic density membrane 0.7544378698224792 0.4027204121848932 0.6871539158736739 1.0 1.0 2 Q15334 1 +Non motile cilium 0.3877773301967451 0.4018391796180896 0.6878023858299893 1.0 1.0 13 P41208,Q9NX58,Q15154,Q15019,Q15555 5 +Er membrane insertion complex 0.545943728034544 0.3833389079633928 0.7014684941409324 1.0 1.0 3 Q7L5D6 1 +Scar complex 0.4408866774207981 0.3751710967728429 0.7075332243241803 1.0 1.0 5 Q8IZP0,Q96F07,Q7L576 3 +Trna methyltransferase complex 0.4595308452401935 0.3694147331981128 0.7118186179205592 1.0 1.0 4 P57081 1 +Filopodium membrane 0.4590161691259315 0.3678048031281075 0.7130187873244209 1.0 1.0 4 P06756,P46939 2 +Eukaryotic translation initiation factor 2 complex 0.5402828017099537 0.3676681839715103 0.7131206668260419 1.0 1.0 3 P20042,Q9BY44 2 +Eukaryotic translation initiation factor 3 complex eif3m 0.3869833254461312 0.3631387509946777 0.7165012384700018 1.0 1.0 8 Q7L2H7,O15372,P55884,Q14152 4 +Intermediate filament 0.381158335163128 0.3615662474585257 0.7176761911205034 1.0 1.0 19 P14923,P15924,Q86UE8,P48729 4 +Cul4a ring e3 ubiquitin ligase complex 0.7235371466140629 0.3293569525670946 0.7418859011532724 1.0 1.0 2 Q92990 1 +Eukaryotic translation initiation factor 3 complex 0.3712526154455306 0.3270328493682521 0.7436430398467024 1.0 1.0 14 P55884,P60228,Q92905,O15371,Q7L2H7,Q14152,O75822,O15372,Q9UBQ5 9 +Tim23 mitochondrial import inner membrane translocase complex 0.4038167277122062 0.3169512515817841 0.7512805921435517 1.0 1.0 6 O60830 1 +Keratin filament 0.7176199868507672 0.3161827345432872 0.7518638118839291 1.0 1.0 2 P48729 1 +Intrinsic component of peroxisomal membrane 0.7163050624589211 0.3132949279100328 0.7540566032572464 1.0 1.0 2 O43808 1 +Cdc73 paf1 complex 0.4362155019885131 0.2996554604133437 0.7644399756000331 1.0 1.0 4 Q6PD62 1 +Translation preinitiation complex 0.3639474624159848 0.2936029573318049 0.7690613157116397 1.0 1.0 15 P55884,Q7Z478,P60228,O15371,Q7L2H7,Q14152,O75822,O15372,Q9UBQ5 9 +Dynein complex 0.3497486638515343 0.2745701006638736 0.7836465399505053 1.0 1.0 9 Q9UJW0 1 +Sumo ligase complex 0.4080881446246729 0.2717388583850538 0.7858228204714377 1.0 1.0 5 Q8IY18 1 +Rna polymerase complex 0.3178704693511699 0.265100197641425 0.7909322750873495 1.0 1.0 37 O14802,Q9Y4A5,Q14181,Q6PD62,Q9BUI4,P18074,P19447,Q9Y6J9,P29083 9 +Main axon 0.3445956002488247 0.2552725642836282 0.7985125886597413 1.0 1.0 9 Q14168,P04350 2 +Rna polymerase ii holoenzyme 0.3535697515985615 0.2547466625089339 0.7989187734239309 1.0 1.0 23 Q6PD62,P18074,P19447,Q9Y6J9,P29083,Q9Y4A5 6 +Microtubule plus end 0.3433280247265293 0.2505991453396886 0.8021240425608211 1.0 1.0 9 Q15555 1 +Microtubule end 0.3418708598220615 0.2372958457731618 0.8124272846743263 1.0 1.0 10 Q15555 1 +Retromer complex 0.35243741765481 0.2363476308535388 0.8131629295740856 1.0 1.0 8 Q9UBQ0,Q9UNH7,O60749,O75436,Q96QK1,Q13596,Q9Y5X3 7 +Anaphase promoting complex 0.3389816969391075 0.2348009832085464 0.8143632045836164 1.0 1.0 9 Q96DE5,Q12834,Q9H1A4 3 +Myelin sheath 0.3387238795799258 0.225994518483673 0.8212056836685664 1.0 1.0 10 Q96A65 1 +Axon cytoplasm 0.3472226157797083 0.2238284339334171 0.8228908041417813 1.0 1.0 21 Q9NZ32,P43034,Q9NVJ2,Q92572,Q14168,P27695,O60333 7 +Ficolin 1 rich granule membrane 0.3474614302385544 0.223083388186618 0.8234706069007045 1.0 1.0 19 P15924,Q5T4S7,Q93050,O75787,Q08554 5 +Intercalated disc 0.3448667720480491 0.2206837815877019 0.8253386605571931 1.0 1.0 15 P15924,P14923 2 +Ccr4 not core complex 0.6686390532544332 0.2188583383901349 0.8267604008241283 1.0 1.0 2 A5YKK6 1 +Plasma membrane raft 0.3437747813922804 0.2096468019496633 0.8339433485935397 1.0 1.0 20 P17612,P19022,P22681,P41440 4 +Intermediate filament cytoskeleton 0.325368622406283 0.2004173232005354 0.8411542123743903 1.0 1.0 31 Q86UE8,P48729,P15924,Q9NU22,P14923 5 +Transcription elongation factor complex 0.3374071447200592 0.1872761328439968 0.8514441351454105 1.0 1.0 18 Q9GZS3,P50750,Q6PD62 3 +Saga complex 0.4598234105887476 0.182020398264411 0.8555667178046824 1.0 1.0 3 Q9Y4A5 1 +Extrinsic component of cytoplasmic side of plasma membrane 0.3359203757639064 0.1813118552812252 0.8561228010814976 1.0 1.0 19 Q05397,Q15334,P31749 3 +Dna polymerase complex 0.3282581274163467 0.177059877432644 0.8594613570932834 1.0 1.0 12 Q9NRF9,Q14181 2 +Rna cap binding complex 0.3538213721835765 0.1679321498601053 0.8666366573520228 1.0 1.0 6 Q7L576 1 +Aster 0.3824355117538671 0.1668280550956754 0.8675053432512825 1.0 1.0 4 Q86Y91 1 +Trans golgi network membrane 0.3269657112440908 0.1660907020576851 0.8680855712112832 1.0 1.0 26 O15127,Q00610,Q7Z6M1,O60499,Q9HC07,O43795,Q15334,Q969E2,Q9H4A5 9 +Nsl complex 0.4508385399539487 0.1660273515855342 0.8681354254342746 1.0 1.0 3 P61964,O15294 2 +Ccr4 not complex 0.3730764160560537 0.148132487229865 0.8822382111663731 1.0 1.0 4 A5YKK6,O95628 2 +Nuclear outer membrane 0.3135270447684716 0.1428200212990073 0.8864323244678542 1.0 1.0 10 Q9UBM7 1 +Intrinsic component of endoplasmic reticulum membrane 0.23317960731811 0.1359996855293212 0.8918215295662539 1.0 1.0 48 Q9Y282,Q92643,Q9NZ01,O75844,Q9UBM7,Q15006 6 +Replication fork 0.2968747410626453 0.1353870737243872 0.8923058437082083 1.0 1.0 35 P49005,Q14181,P41440,P40937,P26358,Q9BY42,Q9Y2S7,P35251,P40938,Q9H4L7 10 +Endoplasmic reticulum golgi intermediate compartment 0.2327427977379471 0.133682861322556 0.8936533581879662 1.0 1.0 48 Q9Y282,P80303,Q92538,Q02818,Q8N511,P33908 6 +Nuclear inner membrane 0.3210547943706508 0.1319218411091176 0.8950461129039502 1.0 1.0 20 Q14739,O75844,Q5JTV8 3 +Trna splicing ligase complex 0.3639608973288019 0.1312375600437089 0.8955873842770492 1.0 1.0 4 Q8NCA5 1 +Replisome 0.3110787049098625 0.1292768824553259 0.8971385630489654 1.0 1.0 11 Q9Y2S7,P49005,Q14181 3 +Pinosome 0.426175600131524 0.1272831263232362 0.8987163149208257 1.0 1.0 3 Q9P2R3,Q06481 2 +Tubular endosome 0.3598684210526453 0.1240750946239322 0.9012558173738268 1.0 1.0 4 Q9UNH7,O75436,Q96QK1 3 +Cell cell contact zone 0.31471936977949 0.1150060471273006 0.908440328935997 1.0 1.0 23 P19022,P15924,P14923,P41440 4 +Sex chromosome 0.3079448990328121 0.1147734863807432 0.9086246649549836 1.0 1.0 12 Q8IY18,Q12824,P24941 3 +Dna packaging complex 0.3100022458538609 0.1089706423696977 0.9132257756352588 1.0 1.0 26 P10412,Q8NB78 2 +Anchored component of synaptic vesicle membrane 0.3504118536008768 0.1085231973038634 0.9135806803928814 1.0 1.0 4 Q15286 1 +Transferase complex transferring phosphorus containing groups 0.2885948283317856 0.1067331173396952 0.9150007088289828 1.0 1.0 78 O14802,P24941,P19447,O95067,P29083,Q07864,Q14181,P50750,Q8IUD2,Q9GZS3,Q9BUI4,P78527,Q9Y6J9,P20248,P11802,P18074,Q9Y4A5,Q6PD62,P12956,P46020,Q9NRF9 21 +Clathrin coat of coated pit 0.3085892631211738 0.1065966755718453 0.915108956068002 1.0 1.0 8 Q13492,Q00610,Q96CW1 3 +Spindle midzone 0.3111580649249702 0.1028725415402511 0.918064130731112 1.0 1.0 19 O43663,Q86Y91,Q96Q89,Q9NVJ2,Q15555 5 +Golgi lumen 0.3341183850820833 0.0979738486057412 0.9219530592317348 1.0 1.0 5 Q9BRK5 1 +Phosphatase complex 0.3062396553180596 0.0976026368197153 0.9222478306265274 1.0 1.0 15 P63151,P30153,P30154,P16333,Q08209 5 +Sarcoplasmic reticulum membrane 0.3043497793057641 0.096167443983944 0.9233875868805924 1.0 1.0 8 Q13555,P62942 2 +Mitochondrial crista 0.3913186451825077 0.0851258083510901 0.9321613726753348 1.0 1.0 3 P18031,O60313 2 +Cytoplasmic microtubule 0.3039702577438512 0.0824119724923313 0.9343191157643906 1.0 1.0 20 P25054,Q86Y91,P43034,Q9H6H4,Q6NUQ4,Q15555 6 +Ikappab kinase complex 0.379050793976842 0.0735963305075413 0.9413315910531944 1.0 1.0 3 Q8IUD2 1 +Hippocampal mossy fiber to ca3 synapse 0.3246710526315914 0.0731108242713746 0.9417179281887385 1.0 1.0 4 O60716,P47756,Q15375 3 +Nuclear replication fork 0.2979670112829696 0.0707999502894902 0.9435569713903252 1.0 1.0 17 Q14181 1 +Cytosolic ribosome 0.2747369971078299 0.0654977074727686 0.9477777315901452 1.0 1.0 76 P62910,P61313,P61927,P46776,P35268,P18077,P36578,P46783,P84098,Q02543,P27635,P62241,P62701,P46778,P18124,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q07020,Q9Y3U8,P83731 25 +Cajal body 0.2845509642185911 0.0654885370557634 0.947785032848663 1.0 1.0 32 P24941,Q14331,O43172,Q06787,Q01844,Q9H089,P22626,P57678,Q16637,Q7L014,Q9NPE3 11 +Lipid droplet 0.2839060900664925 0.0574801629032043 0.9541627076889256 1.0 1.0 31 Q92538,Q8N0X7,Q9H6V9,Q99720 4 +Translocon complex 0.3551463334429494 0.055582732458788 0.9556742207384876 1.0 1.0 3 P60468,P51571 2 +Sec61 translocon complex 0.3551463334429494 0.055582732458788 0.9556742207384876 1.0 1.0 3 P60468,P51571 2 +Spectrin 0.3512002630713563 0.053130332736333 0.9576280635480436 1.0 1.0 3 Q01082,Q13813 2 +Myosin filament 0.3456099967116149 0.0498891819211088 0.960210698145944 1.0 1.0 3 Q7Z406,P35580 2 +Flemming body 0.2896864233138945 0.0480224758910051 0.9616983300988304 1.0 1.0 19 Q96A65,P62826,Q99816,Q96KP1,Q9UPT5,Q02241,Q9NR09 7 +Clathrin vesicle coat 0.2782757427775981 0.0457510366501022 0.9635086850040844 1.0 1.0 11 Q9NVZ3,Q96CW1 2 +Chitosome 0.4825772518080097 0.0410926266471085 0.9672220527235602 1.0 1.0 2 Q04656 1 +Nurf complex 0.3249991171590145 0.0401073299117373 0.968007558080803 1.0 1.0 3 P28370 1 +Caveola 0.2817032087759765 0.0384957410756825 0.9692924270980224 1.0 1.0 15 P41440 1 +Costamere 0.2873601053324587 0.038086798794982 0.9696184767096918 1.0 1.0 6 Q15149,P51114,Q09666,Q12955,P18206 5 +Glycogen granule 0.3077934889838883 0.0342098161736614 0.9727098389492476 1.0 1.0 3 P62140,P49327 2 +Sin3 type complex 0.2840684660961186 0.0337555471936373 0.9730720839269956 1.0 1.0 6 Q9UBU8,Q96ST3,Q13547,Q9H0E3,Q92769 5 +Signal recognition particle 0.2857783498854086 0.0334736417737948 0.9732968848665716 1.0 1.0 5 Q9UHB9 1 +Ciliary membrane 0.2796378133146051 0.0332619587223802 0.9734656895042076 1.0 1.0 4 Q9H4M9 1 +Tight junction 0.2829269076071189 0.0331810101619575 0.9735302414789968 1.0 1.0 24 Q9UDY2,P25054,Q16625,P11802,O43815,Q86UE4,Q68EM7 7 +Septin cytoskeleton 0.2847747451496275 0.0288647189350643 0.9769724841011012 1.0 1.0 3 Q15019,Q9UHD8 2 +Lewy body 0.3984220907297772 0.0273808198216681 0.9781559960783908 1.0 1.0 2 Q13501 1 +Tricarboxylic acid cycle enzyme complex 0.2690495404382178 0.0269572057688089 0.9784938664649652 1.0 1.0 11 P50213 1 +Rna polymerase ii transcription repressor complex 0.3833004602235352 0.0265523821282836 0.978816753410396 1.0 1.0 2 Q9UHI6 1 +Podosome 0.268676302430212 0.0262402549872085 0.979065708089615 1.0 1.0 11 P61978 1 +9plus2 motile cilium 0.2793279052596549 0.0260205108278612 0.9792409787139966 1.0 1.0 19 P21266 1 +Rnai effector complex 0.2742838327296736 0.0254652008556201 0.9796839051748084 1.0 1.0 7 P26196,Q08211,Q9UPY3,Q8IU60,Q9HAV4,Q7KZF4 6 +Female pronucleus 0.2644669136645184 0.0161098084447341 0.9871467885237992 1.0 1.0 5 P11166,P20248 2 +Oxidoreductase complex 0.2180628170775213 0.014902459217819 0.9881099979688664 1.0 1.0 55 O14949,P28331,P50213,O75306,P13804,Q9UDW1,P03886,P11182 8 +Post mrna release spliceosomal complex 0.2633311389071786 0.0106491687747986 0.9915033532429224 1.0 1.0 6 Q69YN2,P52272,Q9HCS7,Q9UBB9,Q9BZJ0 5 +Condensin complex 0.2478530241358316 0.0064170599198404 0.9948799621036182 1.0 1.0 5 Q15003,Q15021 2 +Oligosaccharyltransferase complex 0.2574909450115332 0.0043815351776042 0.99650405191496 1.0 1.0 7 P46977,P04844,P61803,Q8TCJ2,Q9H0U3,P04843 6 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a358eed17d9f434b141c5c55a8fc2cc51dc2e7cc --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Activin receptor complex", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atp binding cassette abc transporter complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc complex", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Cbm complex", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Chylomicron", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Deuterosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Glycosylphosphatidylinositol n acetylglucosaminyltransferase gpi gnt complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi trans cisterna", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner acrosomal membrane", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mks complex", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Phosphorylase kinase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Procentriole replication complex", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BMS1", "BOLA2*", "BOP1", "BPHL", "BRCA1", "BRD2", "BRD4", "BRD8", "BRD9", "BRI3BP", "BRIX1", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "C14orf2", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC25", "CCDC47", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPI", "CENPM", "CENPV", "CEP170", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM234B", "FAM3C", "FAM49B", "FAM83D", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNBP4", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLM2", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISCU", "ISOC1", "IST1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPK1", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYSMD3", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD8", "MGAT1", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRFAP1", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFS1", "NHLRC2", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NTHL1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PAM", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF5A", "PHF6", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PISD", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF40", "RNMT", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAP1", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLK2", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM206", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM43", "TMEM59", "TMEM87A", "TMEM9", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC37", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "UBA1", "UBA2", "UBA5", "UBAP2L", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR61", "WDR73", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC11", "ZCCHC8", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYND8", "ZNF326", "ZNF346", "ZNF622", "ZNF638", "ZW10", "ZYX"], "leading_proteins": ["ABCD4", "ABI1", "ACOX1", "ACTR10", "AHNAK", "AKAP8L", "AKT1", "ANAPC1", "ANAPC16", "ANGEL1", "ANK3", "ANKFY1", "AP2M1", "AP3D1", "AP3S1", "APC", "APEX1", "APLP2", "ARHGAP17", "ARL2", "ARL8B", "ATL3", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "BAIAP2", "BCCIP", "BIRC6", "CALCOCO2", "CAMK2G", "CAPZB", "CBFB", "CBL", "CCNA2", "CCNB2", "CD2BP2", "CDC20", "CDC42", "CDH2", "CDK2", "CDK4", "CDK5", "CDK9", "CELF1", "CEP170", "CETN2", "CFAP20", "CHD3", "CIRBP", "CLASP1", "CLTC", "CNN3", "CNOT1", "CNOT4", "COPA", "COPB2", "COPE", "COPG1", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CREG1", "CRNKL1", "CSNK1A1", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Ligase activity forming carbon carbon bonds 4 7 2.747117484523772 0.0060121593994992 4.62378640776699 6.856796116504855 -2.028273173745319 0.0966053788189329 1.1519157673028364 0.3502806464066411 1.451790697844621 0.2179146178607854 1.0 1.0 0.0017136679159695 1.2610959333897418e-07 4.308021018563364e-06 +Fad binding 2 8 2.6574309041568926 0.0078738729261116 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 3.740100468904226e-05 0.0002664859942285 0.0016919285144831 0.0212613458414498 0.006438505001245 +Threonine type endopeptidase activity 3 8 2.6021432998645224 0.0092643132696985 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.2998708524751297e-05 8.689945997441637e-05 5.179472170036692e-05 0.0007990853642419 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1.4402594392445152 0.6511869496520301 1.1243392396889562 0.2763300958015678 1.0 0.0385773062479974 0.0714416582380786 0.1702318601155425 0.3190458812596383 +Isocitrate dehydrogenase activity 2 5 2.116544630605237 0.0342985135785878 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 1.0 1.0 0.0001168236586544 0.0009539541807411 +Exodeoxyribonuclease activity 1 8 1.9666861633821748 0.0492194030382653 1.941747572815534 9.526699029126211 0.5164494205621982 0.4521403620382715 1.5109647321222988 0.9173440856911084 0.9269071001870416 0.2937909401091823 1.0 0.0892490045576324 0.1614955872519625 0.3581742963758347 0.2230274328678207 +Translation repressor activity 5 8 1.96443460888929 0.0494797126088377 2.621359223300971 8.691747572815533 0.8178109552751379 0.3869214297451314 1.7535899646617803 1.1146116282865457 0.9030508481280868 0.2968248594231644 1.0 1.0 1.0 0.387474652503821 0.0151205151994365 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3903e865800a40ad323cf43f54e55b5b570ff48b --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 1384, + "title": "Average number of proteins per term", + "value": 16.085982658959537 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0fcebc030cbd08ad41c6666523e4fd29feddfb32 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..57d63894509ead5c33b12c2ff6f983baa41c8b75 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,371 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Ligase activity forming carbon carbon bonds 0.939825308220885 2.7471174845237716 0.0060121593994992 0.9997626423285372 0.6798046502087159 7 P11498,O00763,Q96RQ3,P05165 4 +Fad binding 0.8834871108808491 2.6574309041568926 0.0078738729261116 0.999982275615366 0.6798046502087159 8 Q15392,Q8NB78 2 +Threonine type endopeptidase activity 0.8706258849154627 2.6021432998645224 0.0092643132696985 0.9999974554877704 0.6798046502087159 8 P28074,P28070,P49721 3 +Biotin binding 0.9680816057913786 2.5519927784592755 0.0107108738791101 0.9999996632109648 0.6798046502087159 5 P11498,P50747,Q96RQ3,O00763 4 +Threonine type peptidase activity 0.7905731624235832 2.3921592334504274 0.0167495738216754 0.9999999999296644 0.6798046502087159 9 P28074,P28070,P49721 3 +Demethylase activity 0.7908982409917115 2.250964926843362 0.0243877588799956 0.9999999999999986 0.6798046502087159 8 Q8NB78 1 +Rna polymerase core enzyme binding 0.7202712782619041 2.1938208453630437 0.0282482916235196 1.0 0.6798046502087159 20 Q9H7B4 1 +Hydrolase activity acting on ether bonds 0.7931917576577667 2.1241647968234503 0.0336563657682451 1.0 0.6798046502087159 7 O43865,P07099 2 +Isocitrate dehydrogenase activity 0.8597165656075 2.116544630605237 0.0342985135785878 1.0 0.6798046502087159 5 P50213,P48735 2 +Single stranded dna exodeoxyribonuclease activity 0.8666629827280712 1.9910169463390557 0.0464790242203914 1.0 0.6798046502087159 4 Q9UQ84 1 +Exodeoxyribonuclease activity 0.7286656342119331 1.9666861633821748 0.0492194030382653 1.0 0.6798046502087159 8 Q9UQ84 1 +Translation repressor activity 0.7281802528729837 1.96443460888929 0.0494797126088377 1.0 0.6798046502087159 8 P00374,P34897,Q92879,Q14011,P34896 5 +Atp dependent activity acting on dna 0.4321510518439082 1.9557292763607317 0.0504970540376865 1.0 0.6798046502087159 48 P33993,Q9BXF3,P19447,P41440,P40937,Q9H2U1,Q92499,Q9H4L7,Q12873,P35251,P18074,O00571,P28370,Q96QE3,P12956,O14646,P52701,P33991,P40938 19 +Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication 0.8555868818915531 1.9463533828447357 0.0516123052342731 1.0 0.6798046502087159 4 P15924 1 +Prenyltransferase activity 0.8539482565110157 1.939730669632805 0.0524124302437338 1.0 0.6798046502087159 4 P49356,P37268 2 +Flavin adenine dinucleotide binding 0.6544450727250463 1.9109767002563536 0.0560075752022526 1.0 0.6798046502087159 23 Q15392,Q15067,Q8NB78,O95831,P13804 5 +Organic cation transmembrane transporter activity 0.8005918434848545 1.8704042254800677 0.0614277056434073 1.0 0.694127513637629 5 O43772 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.6746916869187366 1.8496638592146295 0.0643620125442641 1.0 0.694127513637629 12 O15091,Q9BQ52,Q99575,Q96F86,Q9UQ84,Q9UPY3 6 +Metalloaminopeptidase activity 0.6751417199635463 1.8482626629458692 0.0645643542545417 1.0 0.694127513637629 11 P55786,Q9NZ08 2 +Rna polymerase binding 0.6081500016564465 1.765487779262234 0.0774818223229145 1.0 0.694127513637629 27 Q9H7B4 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6069043954388366 1.7579234108595458 0.0787605418594741 1.0 0.694127513637629 27 Q32P28,Q16850,Q8NB78,Q9BU89 4 +Pentosyltransferase activity 0.6540178735897842 1.75036860744682 0.0800547293148339 1.0 0.694127513637629 13 Q13126 1 +14 3 3 protein binding 0.8072045645592705 1.749260761261265 0.0802459553338299 1.0 0.694127513637629 4 Q9UBF8,P78362 2 +Sh2 domain binding 0.6807101758518768 1.741799747082525 0.0815434909878687 1.0 0.696822315158433 8 Q05397,A1X283,Q6PD62 3 +Cytoskeletal anchor activity 0.7333324528254666 1.7313430767366542 0.0833905927241365 1.0 0.696822315158433 6 Q9UQB8 1 +Monooxygenase activity 0.6746575081051663 1.7130816528198451 0.0866975188727923 1.0 0.7162887814734047 8 Q16850,P30519,Q9BU89 3 +Aminopeptidase activity 0.6435083556860608 1.6967445211067842 0.0897449716012914 1.0 0.7162887814734047 13 Q9NZ08,Q13867,Q9H4A4,Q9UIQ6,P55786 5 +Extracellular matrix binding 0.6965177275075396 1.6891236726897585 0.0911957321554175 1.0 0.7162887814734047 7 O94813,P20248 2 +Cadherin binding involved in cell cell adhesion 0.6423272807987129 1.684059592299846 0.0921701525132763 1.0 0.7162887814734047 10 Q15417,Q9UQB8 2 +Nucleobase containing compound transmembrane transporter activity 0.6390627027069159 1.6796727344925413 0.0930210074962378 1.0 0.7162887814734047 14 Q9BSK2,P51991,O43808,P41440 4 +Fk506 binding 0.6891669410602381 1.655335913932355 0.0978563777517331 1.0 0.7162887814734047 7 Q9Y680,Q00688,Q13451,Q02790,P62942,P26885 6 +Macrolide binding 0.6891669410602381 1.655335913932355 0.0978563777517331 1.0 0.7162887814734047 7 Q9Y680,Q00688,Q13451,Q02790,P62942,P26885 6 +G protein coupled receptor activity 0.9013482407102886 1.6546568674621052 0.0979941210394201 1.0 0.7162887814734047 3 O43813,P48960 2 +Structural constituent of muscle 0.7840489197924483 1.653894315339676 0.0981489878849641 1.0 0.7162887814734047 4 Q16527 1 +Chemokine receptor binding 0.7486416958808084 1.6496873232169855 0.0990069043012307 1.0 0.7162887814734047 5 Q96J02,P48681,O43776 3 +Translation repressor activity mrna regulatory element binding 0.7485523474646886 1.6493045792001837 0.0990852520012857 1.0 0.7162887814734047 5 P34897,Q92879,P34896 3 +Dna clamp loader activity 0.7145016513753613 1.6479177916194738 0.099369541938507 1.0 0.7162887814734047 6 P40937,P40938,P41440 3 +Protein phosphatase 2a binding 0.6328875140016377 1.6369739215377348 0.1016359186926618 1.0 0.7176740381155307 11 P78318,O43815 2 +Basal transcription machinery binding 0.5809477580185589 1.634173202636393 0.1022224876115931 1.0 0.7181152416832812 28 Q9H7B4 1 +Organic acid binding 0.5532096801905805 1.6219042616125372 0.104823848928373 1.0 0.7290261654113984 32 P11498,P05165,P41440,P34897,Q15046,Q96RQ3,Q32P28,O00763,P50747,Q00169,P34896 11 +Carboxylic acid binding 0.5364149537840922 1.608176216232646 0.1077965905693179 1.0 0.7313258889604703 34 P11498,Q15067,P05165,P41440,P34897,Q96RQ3,Q32P28,Q9UM22,O00763,P50747,Q00169,P34896 12 +Macromolecule transmembrane transporter activity 0.6239218299030835 1.593052152553594 0.1111484919011955 1.0 0.7390875554663475 12 P51991,O60830,Q9NS69 3 +Phosphatidylinositol 3 5 bisphosphate binding 0.702051888351067 1.5924810553932234 0.1112766564908158 1.0 0.7390875554663475 6 Q9Y4P8,Q92538 2 +Transition metal ion transmembrane transporter activity 0.7334854920937195 1.5846272553284313 0.1130510486344276 1.0 0.7390875554663475 5 Q15043,Q9HD20 2 +Nucleotide transmembrane transporter activity 0.6216748490452217 1.5815739865151104 0.1137468564409913 1.0 0.7390875554663475 12 Q9BSK2,O43808,P41440 3 +Organophosphate ester transmembrane transporter activity 0.6216748490452217 1.5815739865151104 0.1137468564409913 1.0 0.7390875554663475 12 Q9BSK2,O43808,P41440 3 +Channel inhibitor activity 0.6965776821331282 1.568039825180279 0.1168718383876799 1.0 0.74405802710021 6 Q96PU5 1 +Proteasome binding 0.6170471421729683 1.5597513470377329 0.1188186529098382 1.0 0.7482497971204045 9 Q14997,Q5VYK3,O95456 3 +Molecular function activator activity 0.6158186122958759 1.5516160735841174 0.1207541148269792 1.0 0.7520835530976682 12 O60884,Q5JTV8,P31749,Q99543,P31689 5 +Cullin family protein binding 0.7242513984863449 1.544863772749001 0.1223792178016169 1.0 0.7520835530976682 5 O60826,Q92564,P63208,Q9NXV2 4 +Sodium channel regulator activity 0.870893640574982 1.539437200228421 0.1236975981836097 1.0 0.7520835530976682 3 Q96PU5 1 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.6106205475461259 1.531833384701999 0.1255635554627807 1.0 0.7527535819070016 14 O15091,Q9BQ52,Q99575,Q96F86,Q9UQ84,P51530,Q9UPY3,P27695 8 +Myosin binding 0.6364589190707057 1.530307230616868 0.1259406993635496 1.0 0.7527535819070016 8 Q15334,P61026,P61586,Q96J84 4 +Trna specific ribonuclease activity 0.7540022192099384 1.52932406586958 0.1261841264468384 1.0 0.7527535819070016 4 Q99575,Q9BQ52 2 +Ephrin receptor binding 0.6101336014146324 1.5252006783126977 0.1272090514710679 1.0 0.7531210713365816 9 P16333,P22681,Q92625,Q00535 4 +Alpha catenin binding 0.7528904241336722 1.5246995503500231 0.1273340539687573 1.0 0.7531210713365816 4 P14923 1 +Molecular function inhibitor activity 0.6034965632900215 1.4891047795097587 0.1364597794247619 1.0 0.7666846678441128 10 Q96PU5,Q96ST3,Q9NRX4 3 +Atp dependent chromatin remodeler activity 0.7089723761101513 1.4788873971772123 0.1391704121940353 1.0 0.7666846678441128 5 Q12873,Q9BXF3,Q9H4L7 3 +Transferase activity transferring one carbon groups 0.4162636796041006 1.4408423127652803 0.1496292364943647 1.0 0.7666846678441128 62 Q9H7B4,O60725,Q9NRG4,P26358,P34897,Q96P11,Q8N1G2,P57081,Q6FI81,Q6P2P2,Q9BV86,Q9H993,P34896 13 +Eukaryotic initiation factor 4e binding 0.7323535134308601 1.4391216629957655 0.1501160552985498 1.0 0.7666846678441128 4 Q9UNK9 1 +Lys48 specific deubiquitinase activity 0.72894736842106 1.4249038532694518 0.1541849956586083 1.0 0.7725083726326438 4 Q6GQQ9,Q93009,Q93008 3 +Cytokine activity 0.6617537102718444 1.4117561704759942 0.1580217679045572 1.0 0.7725083726326438 6 P43490 1 +Phosphatidylinositol bisphosphate binding 0.5819046989796974 1.4008880638530632 0.1612475486510347 1.0 0.7725083726326438 17 A1X283,Q13045,O43795,Q9Y4P8,Q92538 5 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.8340953702963894 1.3996592386027416 0.1616153854907782 1.0 0.7725083726326438 3 Q16850 1 +Atpase activator activity 0.5846282949008399 1.3914794381802769 0.1640800905579511 1.0 0.7725083726326438 11 P31689,O60884,Q99543,Q5JTV8 4 +Glutathione transferase activity 0.6067797241642422 1.3867509193285033 0.1655177279091844 1.0 0.7731580208708153 8 O15217,P21266 2 +Iron ion binding 0.5749209462603765 1.372952196857572 0.1697672081160766 1.0 0.7805907509390365 18 Q32P28,Q16850 2 +Protein arginine omega n asymmetric methyltransferase activity 0.8237421900690568 1.3602826374949704 0.1737405005662589 1.0 0.7907870688721758 3 O60678,Q86X55 2 +Protein arginine omega n monomethyltransferase activity 0.8237421900690531 1.3602826374949557 0.1737405005662635 1.0 0.7907870688721758 3 Q6P2P2,O60678 2 +Protein carboxyl o methyltransferase activity 0.8226726761795289 1.3562147580764436 0.1750308477329385 1.0 0.791642788439173 3 O60725 1 +Hydroxymethyl formyl and related transferase activity 0.7082967762030148 1.3386057640697666 0.180699048669223 1.0 0.8063188775611674 4 P34897 1 +Intermediate filament binding 0.7075657894736909 1.3355488304767031 0.1816967846603767 1.0 0.8063188775611674 4 P48681,Q96EB6,P58107 3 +Transcription coactivator binding 0.6754224636633828 1.3334137143446074 0.1823960742733059 1.0 0.8065053252212634 5 Q15648,P50750 2 +Single stranded dna helicase activity 0.5716774674832529 1.3241435326568656 0.1854553801503939 1.0 0.8096853190162311 12 P33993,P40937,P51530,P33991,P40938 5 +Cyclin dependent protein serine threonine kinase regulator activity 0.6417026674828679 1.3212913863150109 0.1864042249600448 1.0 0.8112687023418302 6 P11802,O95067 2 +S adenosylmethionine dependent methyltransferase activity 0.3797868967225336 1.316376821310885 0.1880475981303253 1.0 0.8155907792267091 47 Q9H7B4,O60725,Q9NRG4,P26358,Q96P11,Q8N1G2,P57081,Q6P2P2,Q9H993 9 +Vitamin binding 0.410672009859805 1.3148036432697414 0.1885759027113778 1.0 0.8155907792267091 44 P11498,P05165,P41440,Q96RQ3,Q32P28,O00763,P50747 7 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.6154208132051291 1.3122870804839215 0.1894232896338019 1.0 0.8167035291376383 7 P50750 1 +Histone arginine n methyltransferase activity 0.8102597829661287 1.3090086604630156 0.1905314171339263 1.0 0.8178288861273512 3 Q99873,Q86X55 2 +Protein arginine n methyltransferase activity 0.6365938425167108 1.2982064680365124 0.19421639611955 1.0 0.8178897126942977 6 Q99873,O60678,Q86X55,Q6P2P2 4 +Cytokine receptor binding 0.5591987272162062 1.2975962978401407 0.1944260949974161 1.0 0.8178897126942977 19 P48681,O43776,P42224,Q9NZ08,P14174,P62942,Q96J02,Q9H2J4 8 +Protein transmembrane transporter activity 0.5654982099126409 1.2932882917201085 0.1959113685742879 1.0 0.8216404063842863 11 O60830,Q9NS69 2 +Transferase activity transferring sulphur containing groups 0.6082043475210689 1.278441955986334 0.2010936385158446 1.0 0.8321292401861119 7 Q06520 1 +O methyltransferase activity 0.5842208398964767 1.2770055663433983 0.2016002820909621 1.0 0.8321292401861119 8 O60725,Q8N1G2 2 +Pre mirna binding 0.6587740902906327 1.261055759382986 0.2072887584238745 1.0 0.846043043980372 5 Q9H2U1,P62826,Q9UPY3 3 +Ccr chemokine receptor binding 0.79710621506083 1.2590183374172594 0.2080237085289702 1.0 0.846043043980372 3 P48681,O43776 2 +Histone methyltransferase activity 0.5373151835847664 1.254927044290325 0.2095052453878008 1.0 0.846043043980372 24 Q9H7B4,Q9NRG4 2 +Manganese ion transmembrane transporter activity 0.7954620190726724 1.2527734805637054 0.210288155440208 1.0 0.846043043980372 3 Q15043,Q9HD20 2 +Pre mrna intronic binding 0.6564659427443106 1.2510218741528736 0.2109264969471609 1.0 0.8461515123909297 5 P14866,P22626,Q9BWF3,Q13148 4 +3 5 exodeoxyribonuclease activity 0.6543334356302635 1.241751743223876 0.2143281724124079 1.0 0.8558040585391141 5 Q07864 1 +Alpha tubulin binding 0.6528754848972025 1.235414177528609 0.2166763990037243 1.0 0.8558040585391141 5 Q9NVJ2 1 +Cyclin dependent protein kinase activity 0.5738511910002217 1.226450617565409 0.2200291478275637 1.0 0.8558040585391141 8 P11802,P50750,P24941 3 +Vitamin d receptor binding 0.5729315568197297 1.2219653093000535 0.2217207459593013 1.0 0.8558040585391141 8 O75448,Q93074,Q15648,Q9NPJ6,Q9NVC6 5 +Monocarboxylic acid binding 0.5485084117405414 1.212889592472702 0.2251720352518185 1.0 0.8563264269197634 16 P11498,Q15067,P05165,Q96RQ3,O00763,P50747,Q00169 7 +Calcium channel inhibitor activity 0.7817214194622379 1.200634760189791 0.229892911171746 1.0 0.8563264269197634 3 Q9NRX4 1 +7sk snrna binding 0.6442732677965348 1.1980288852935608 0.2309057720023068 1.0 0.8563264269197634 5 Q4G0J3,P50750 2 +Purine nucleotide transmembrane transporter activity 0.5448130814302283 1.195567336798404 0.2318654442309558 1.0 0.8563264269197634 9 P41440 1 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 0.6132761852451971 1.1927676301801713 0.2329603906499819 1.0 0.8563264269197634 6 Q9UQ84,Q9UPY3,P27695 3 +Mitochondrial ribosome binding 0.671158347241035 1.1833301270654584 0.2366783373365633 1.0 0.8563264269197634 4 Q9BSH4 1 +Calcium dependent protein serine threonine phosphatase activity 0.776790470953862 1.1819510885885238 0.2372251088763159 1.0 0.8563264269197634 3 Q13555 1 +Lysine n methyltransferase activity 0.5404323272532385 1.1755307867966984 0.2397824276146396 1.0 0.8563264269197634 17 Q9H7B4 1 +Histone lysine n methyltransferase activity 0.5404323272532385 1.1755307867966984 0.2397824276146396 1.0 0.8563264269197634 17 Q9H7B4 1 +Calcium channel regulator activity 0.6383767030876023 1.1724152067441769 0.2410303971380967 1.0 0.8563264269197634 5 Q9NRX4 1 +Thyroid hormone receptor binding 0.5410784556549435 1.1713453439277903 0.2414599920440827 1.0 0.8563264269197634 10 O75448,Q93074,Q15648,Q9NPJ6,Q9H0E9,Q9NVC6 6 +Dynactin binding 0.6653996938656663 1.1592937193788813 0.2463364809597339 1.0 0.863113138350055 4 P42858 1 +Sulfur compound binding 0.3634368973103785 1.1563607152159672 0.2475336433074322 1.0 0.8651175816603187 47 P11498,Q96RQ3,P21266,Q06520,O00763,P50747 6 +Phosphatidylinositol 4 5 bisphosphate binding 0.5365425775606034 1.1418633532191704 0.253510823527411 1.0 0.8770145371439475 12 P07355,Q12792,Q13045,Q13492,O43795,Q15286,O00560,P35080 8 +Metalloexopeptidase activity 0.5283998303250284 1.1374372917901745 0.2553555252254025 1.0 0.8770145371439475 20 Q99829,Q96KP4,Q9NZ08,Q7Z2K6,O75844,Q9UIQ6,P55786 7 +Ribosomal large subunit binding 0.5555943243658157 1.1373943871301115 0.2553734526510194 1.0 0.8770145371439475 8 O94822,Q96D46 2 +Vitamin transmembrane transporter activity 0.5766051861759587 1.1301232904303475 0.2584242770741773 1.0 0.8815904592056976 7 P41440 1 +Carbohydrate derivative transmembrane transporter activity 0.5317554307160088 1.123702143359585 0.2611394068411135 1.0 0.8858258310492673 10 P41440 1 +K63 linked polyubiquitin modification dependent protein binding 0.6562500000000101 1.1211517130310626 0.262223289571025 1.0 0.8861280084463966 4 Q6GQQ9,Q13501,Q8TAT6 3 +Ubiquitin like protein transferase activity 0.3753800738446415 1.1111210536962195 0.2665162466899309 1.0 0.891028113582397 59 O95376,P22681,Q96PU5,Q15386,O75448,O95628,Q93074,Q5T4S7,P60953,O94822,Q5VTB9,Q9UPN9,Q6W2J9,O95071,Q96J02,Q96MF7 16 +Actinin binding 0.5942626238219317 1.1068519487100226 0.2683579438058674 1.0 0.8928062361233665 6 Q16527 1 +Ubiquitin like protein ligase activity 0.4126053039441186 1.0988342826630897 0.2718403556786724 1.0 0.8978606568397278 41 O95376,P22681,Q96PU5,Q15386,O75448,Q93074,Q5T4S7,P60953,O94822,Q5VTB9,O95071,Q96J02,Q96MF7 13 +Gtpase inhibitor activity 0.5921653348961043 1.0973872040961177 0.2724721646478942 1.0 0.8978606568397278 6 O94813,O43924 2 +Structural constituent of postsynapse 0.648469364448729 1.088776168820617 0.2762526031733032 1.0 0.9038619451344012 4 Q15334 1 +G quadruplex dna binding 0.6454627789863119 1.0762831042851897 0.2818006625856593 1.0 0.90984185825692 4 P22392,Q9H2U1 2 +Protein kinase a regulatory subunit binding 0.5835126361894194 1.058378616676616 0.2898828641755155 1.0 0.913206230510495 6 Q96M27 1 +Phosphatidylinositol 3 phosphate binding 0.6105900095958285 1.052023622418646 0.2927887118262413 1.0 0.913206230510495 5 Q9Y4P8 1 +Oligopeptide binding 0.610586937276231 1.0520103526596878 0.2927947998678806 1.0 0.913206230510495 5 P21266 1 +Endopeptidase activity 0.3881662577906889 1.0516394420480402 0.2929650045857368 1.0 0.913206230510495 67 O43847,Q9Y4P1,P49721,P28074,P20618,Q16740,Q13867,P36776,P28070,P07384,Q96K76,Q9NZ08,Q5TDH0,Q99829,Q9BYT8,P60900,O75844,Q96RU2,Q9UPU5,Q92643,Q4J6C6 21 +Cis regulatory region sequence specific dna binding 0.3873505456760003 1.029662159861826 0.3031686246306821 1.0 0.9344885890620582 43 Q9H7B4,Q12948,P50750,Q93074 4 +Amide transmembrane transporter activity 0.6316612545796041 1.0190865023872129 0.308161901531045 1.0 0.9435753799092176 4 P41440 1 +Gamma catenin binding 0.6021037459899068 1.01541895089634 0.3099061632503588 1.0 0.945366955194242 5 P19022,Q14574 2 +Metal dependent deubiquitinase activity 0.5517078201145736 1.0135527422306618 0.3107962172061995 1.0 0.945366955194242 7 Q92905,P51665,Q7L5N1,Q6P2Q9,O15372 5 +Cell adhesion mediator activity 0.5058979366163332 1.011399889702138 0.311825073948897 1.0 0.9464164525115648 20 Q15417,P15924,Q9UQB8,P14923 4 +4 iron 4 sulfur cluster binding 0.5050634247896424 1.006742869744594 0.3140583551364968 1.0 0.9511088917044018 20 Q07864,Q9Y5Y2,P28331,O75306,P18074,Q9H9T3 6 +Plus end directed microtubule motor activity 0.5715322519050176 1.0045052366565363 0.3151351484083553 1.0 0.9517949751866288 6 Q86Y91,Q96Q89 2 +Cell cell adhesion mediator activity 0.5071426991965428 1.0009991275798835 0.3168272301627994 1.0 0.9532367098811184 18 Q15417,P15924,Q9UQB8,P14923 4 +Protein deacetylase activity 0.6247743494309246 0.9906560570658752 0.3218535551254053 1.0 0.9637841200654228 4 O94776 1 +Sulfotransferase activity 0.9490466798159154 0.9888830378319056 0.322720370425233 1.0 0.9637841200654228 2 Q06520 1 +Adenylyltransferase activity 0.5946321215659491 0.9832821761374788 0.325468579948641 1.0 0.9648700238383662 5 O43252 1 +Translation initiation factor binding 0.5048591428975953 0.9826805156370194 0.3257647032177031 1.0 0.9648700238383662 17 Q9UNK9,P55884,P55010,P16333,O00571,Q7L2H7 6 +Palmitoyltransferase activity 0.5944572297610253 0.9825310870545566 0.3258382756310132 1.0 0.9648700238383662 5 P23786 1 +Dna helicase activity 0.4462290928062424 0.979550977795087 0.3273078133051061 1.0 0.9658720972585648 34 P33993,Q12873,Q9H2U1,P18074,P12956,O00571,P19447,O14646,Q9H4L7 9 +Metallopeptidase activity 0.3973197794503078 0.9750055274957794 0.3295575181231021 1.0 0.9689523035344404 41 O43847,Q99829,Q9BYT8,Q9NZ08,Q7Z2K6,O75844,Q9UIQ6,P55786 8 +Ribonuclease p activity 0.7216097089694434 0.9746138686557893 0.3297518316219086 1.0 0.9689523035344404 3 Q99575 1 +G protein alpha subunit binding 0.5915557509795655 0.9700786790152792 0.3320072756510375 1.0 0.9723116300147449 5 P80303 1 +Phosphatase binding 0.3416126546012917 0.9690301425096032 0.3325301501302105 1.0 0.9723116300147449 51 Q05397,Q9UPR3,Q8IV63,P78318,O43815,P49815,P14923,Q9UPN7 8 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.5032534429250716 0.967495030909619 0.3332966241351489 1.0 0.9723116300147449 15 Q14739,Q15392,Q14914 3 +Protein methyltransferase activity 0.4599079842942434 0.9620293607410616 0.3360348555890846 1.0 0.9723116300147449 31 Q9H7B4,Q9NRG4 2 +Annealing activity 0.5193422856078307 0.9610894264671896 0.3365072056486275 1.0 0.9723116300147449 8 Q06787,P28370,O00571,P51114 4 +Channel regulator activity 0.5008030884940547 0.9545509993868836 0.3398048070266881 1.0 0.9723116300147449 15 Q96PU5,P31749,Q9NRX4,Q8N335 4 +Chemoattractant activity 0.615941217394563 0.9543210294240776 0.3399211663825947 1.0 0.9723116300147449 4 P09429,P14174 2 +Rna strand annealing activity 0.5851513671988622 0.9426514445731464 0.3458592168688694 1.0 0.9723116300147449 5 Q06787,O00571,P51114 3 +G protein activity 0.4958372231630201 0.927853459389009 0.3534835889177654 1.0 0.9804033808861472 14 P61586,Q9NVJ2,P60953,P61026,P62820 5 +Keratin filament binding 0.7073331141072019 0.921768628798514 0.3566492742790013 1.0 0.9820698414749336 3 Q96EB6,P58107 2 +Amino acid binding 0.4924997585174568 0.9183218367330328 0.3584503982864171 1.0 0.9820698414749336 11 P34897,P34896 2 +Oxidized dna binding 0.5789269815022436 0.9160805614735688 0.3596246423735165 1.0 0.9820698414749336 5 P18887 1 +Phosphatidylinositol binding 0.3400706652384361 0.9070718283453448 0.3643688145314012 1.0 0.9887969398263908 53 O60784,Q92643,Q15036,A1X283,Q92783,Q13045,O43795,P22059,Q9Y4P8,Q92538,P35080,P31749,Q00169,Q9H4A5 14 +Guanylate kinase activity 0.7028424191826088 0.90524072217146 0.3653378726176197 1.0 0.9894865277941012 3 Q14168 1 +Sh3 domain binding 0.4831167578685884 0.8849689529466517 0.3761733765971475 1.0 0.996555701859016 20 Q9UJC5,P22681,O43813,Q96EY5,Q68EM7,Q07666,Q96PU8 7 +Calmodulin binding 0.4197800790734136 0.8792262038407863 0.3792786392667935 1.0 0.996555701859016 36 Q15417,O76024,P11171,Q01844,Q99439,O43815,Q5T4S7,O43795,Q13555,P46020,Q08209,P31749 12 +Adp transmembrane transporter activity 0.5967277477164581 0.8759026055966315 0.3810829829294246 1.0 0.996555701859016 4 O43808 1 +Tetrapyrrole binding 0.4850122372361778 0.8730640280359957 0.3826281794506121 1.0 0.996555701859016 16 Q16850,P30519 2 +Primary mirna binding 0.6929844152368896 0.8691371159932604 0.3847721376926767 1.0 0.996555701859016 3 P40763 1 +G rich strand telomeric dna binding 0.5653175386640422 0.8583270320128356 0.3907119068090692 1.0 1.0 5 P15927,P27694,P22626,P09651 4 +Profilin binding 0.5873412398549951 0.8379644318429477 0.4020506799135594 1.0 1.0 4 Q8N8S7,P42858 2 +Deacetylase activity 0.5337832594613388 0.8365122744485096 0.402866774431426 1.0 1.0 6 O94776,Q96EB6 2 +Transferase activity transferring alkyl or aryl other than methyl groups 0.471880073426816 0.832323339430159 0.4052264600941435 1.0 1.0 21 P37268,O43813,P21266,P53611,O15217,P49356 6 +Peptide alpha n acetyltransferase activity 0.5582735339266581 0.8286488293109442 0.4073031489467416 1.0 1.0 5 Q9BXJ9 1 +Potassium channel regulator activity 0.5319513141659119 0.8284553865560518 0.4074126507456421 1.0 1.0 6 Q96PU5 1 +Nadp binding 0.475016265041371 0.8230424248639211 0.4104838681206693 1.0 1.0 17 P00390,Q14739,O75874,Q9UBM7 4 +Nucleotidase activity 0.5305935683562026 0.8224912266623072 0.4107973778755065 1.0 1.0 6 Q969T7 1 +General transcription initiation factor activity 0.5833100138232623 0.8217584934953113 0.411214360938346 1.0 1.0 4 P29083 1 +H4 histone acetyltransferase activity 0.6780664255179023 0.8150255542341974 0.4150576827957479 1.0 1.0 3 Q86UY6,Q9GZZ1 2 +Dipeptidase activity 0.5756759354104044 0.7912267229413664 0.4288117000671863 1.0 1.0 4 Q96KP4,Q8IYS1 2 +Nedd8 specific protease activity 0.6691877671818309 0.7831592424643301 0.4335336056578007 1.0 1.0 3 Q96FW1,Q9BT78 2 +Telomeric dna binding 0.4665478183581583 0.7820695376080196 0.4341737080497427 1.0 1.0 18 Q9UPR3,P12956,Q9HAU5 3 +Er retention sequence binding 0.8846153846153925 0.7778687949463922 0.4366463661923407 1.0 1.0 2 O43731 1 +Ionotropic glutamate receptor binding 0.5189792699807407 0.7717444448070591 0.4402658015123928 1.0 1.0 6 P41440 1 +Protein phosphatase binding 0.3552092013625316 0.7602192575807709 0.4471235357139913 1.0 1.0 43 Q05397,Q9UPR3,Q8IV63,P78318,O43815,P14923,Q9UPN7 7 +Signaling receptor complex adaptor activity 0.5161638911742802 0.75952243565183 0.4475400982859034 1.0 1.0 6 P37198,P16333,Q96T76 3 +Dna n glycosylase activity 0.5114364056820813 0.7390761563328585 0.4598607544451736 1.0 1.0 6 P13051,P78549,P29372,P27695 4 +Oxidoreductase activity acting on the ch ch group of donors 0.440184583498734 0.7384276028070379 0.4602546461488888 1.0 1.0 27 Q15392,Q14739,Q14914,Q7KZN9,Q9NZ01,Q9UBM7 6 +N methyltransferase activity 0.4361281708151295 0.7345225476807323 0.4626303232413349 1.0 1.0 28 Q9H7B4 1 +Protein prenyltransferase activity 0.868507560815263 0.727050566921206 0.4671949794144994 1.0 1.0 2 P49356 1 +Nadplus adp ribosyltransferase activity 0.5558685716257701 0.7131118407066138 0.475776553052823 1.0 1.0 4 Q9ULX3,Q96EB6 2 +Protein serine kinase activity 0.3194281447040095 0.7110275388675156 0.4770671706823719 1.0 1.0 53 P17612,P78362,P24941,P48729,Q86UE8,P11802,Q05655,P50750,Q00535,Q13418,Q96KB5,P31751,Q13546,P78527,Q13555,P31749,P42345 17 +3 5 dna helicase activity 0.4442724796919645 0.6918214388322107 0.4890494714074531 1.0 1.0 9 P49736,P33993,P19447 3 +P53 binding 0.4440151611900003 0.6892510826182003 0.4906652756789289 1.0 1.0 22 O14744,Q12824,Q9NRG4,P42858,Q00535,Q9NPI1 6 +Ubiquitin like protein specific protease activity 0.4068776436489439 0.6822253764185314 0.4950964508960029 1.0 1.0 33 O15372,Q9Y4P1,Q96RU2,Q9UPU5,Q93008,Q96K76,Q6GQQ9,Q92890,Q93009,Q96FW1,Q7L5N1,Q99496,Q9BT78,Q9NUQ7 14 +Dynein intermediate chain binding 0.4780001410787314 0.67643206377508 0.4987663655220646 1.0 1.0 7 P43034,P42858 2 +Poly g binding 0.5210773666885429 0.6751563713874614 0.4995764220700556 1.0 1.0 5 Q06787,O14979 2 +Oxidoreductase activity acting on diphenols and related substances as donors 0.6381268185725901 0.6740858321323266 0.5002567463611305 1.0 1.0 3 Q9UDW1 1 +Ubiquinol cytochrome c reductase activity 0.6381268185725901 0.6740858321323266 0.5002567463611305 1.0 1.0 3 Q9UDW1 1 +Metalloendopeptidase activity 0.4449794321241631 0.6673922765474122 0.5045215979863662 1.0 1.0 14 Q9BYT8,O75844 2 +Folic acid transmembrane transporter activity 0.849112426035518 0.6671827401491109 0.5046554145320838 1.0 1.0 2 P41440 1 +Modified amino acid transmembrane transporter activity 0.849112426035518 0.6671827401491109 0.5046554145320838 1.0 1.0 2 P41440 1 +Transcription regulator inhibitor activity 0.6353173298257027 0.6644315886530371 0.5064141207435204 1.0 1.0 3 Q9NX58,Q96ST3 2 +Ribosome binding 0.3884000911356084 0.6623303093953444 0.5077595562162129 1.0 1.0 36 Q06787,O76094,Q07021,O60678,Q92616,Q7Z739,Q9BSH4,P42345,Q9UHB9,Q9BXJ9,Q9UBQ5,Q99543 12 +Nadh dehydrogenase activity 0.4381552902902549 0.6493251307739756 0.5161282454186271 1.0 1.0 21 P03886,O95831 2 +Peptide lysine n acetyltransferase activity 0.45348102839299 0.6490415022193434 0.5163115510051908 1.0 1.0 8 Q86UY6,O75448,O14929,Q9GZZ1 4 +Non membrane spanning protein tyrosine kinase activity 0.4894132946186094 0.6452794366649517 0.5187461160741962 1.0 1.0 6 Q05397 1 +Scaffold protein binding 0.4373321767291412 0.6333130968716075 0.5265292023432737 1.0 1.0 19 Q9Y4P1,P15924,Q9UQB8,Q15334,P12956 5 +Calmodulin dependent protein kinase activity 0.8356344510190672 0.6265332771953759 0.5309652170574535 1.0 1.0 2 Q13555 1 +Cytoskeletal motor activity 0.4206539874975561 0.6097588476449928 0.5420215657149035 1.0 1.0 26 P60660,Q86Y91,Q96Q89,Q9BW19,O43795,Q13526,Q02241 7 +Chemokine binding 0.6179159063371711 0.605545026175215 0.5448169167452797 1.0 1.0 3 P06756 1 +N acetyltransferase activity 0.4304500777891011 0.5935619432336274 0.5528051412846438 1.0 1.0 15 Q86UY6,Q9H9T3,Q9BXJ9 3 +N acyltransferase activity 0.4288108910281652 0.5896741550142021 0.5554091255836968 1.0 1.0 19 Q86UY6,Q9H9T3,Q9BXJ9,Q96G23 4 +Pdz domain binding 0.4257891069884322 0.5875977522208748 0.5568023201470866 1.0 1.0 11 Q96A65,Q15067,Q9UQB8,Q15334 4 +Rna 7 methylguanosine cap binding 0.4397105542163635 0.5865391836377506 0.5575132379425776 1.0 1.0 8 Q8TEQ6,Q96F07,Q6PKG0,Q7L576 4 +Ubiquitin conjugating enzyme binding 0.4386118474973116 0.581611636992646 0.5608283027215255 1.0 1.0 8 O95376,Q92564,Q9H0E2 3 +Phosphatidylinositol 3 4 5 trisphosphate binding 0.4210488701366092 0.572456321018068 0.5670128691487846 1.0 1.0 10 O43795,Q92538 2 +Peptide n acetyltransferase activity 0.4180538433258137 0.5510606988664218 0.5815920655672544 1.0 1.0 11 Q86UY6,Q9BXJ9 2 +Lamin binding 0.4309032234035743 0.5473113690062426 0.5841648344581964 1.0 1.0 8 Q14739 1 +Sphingosine n acyltransferase activity 0.8083497698882485 0.5469737792292555 0.5843967463740782 1.0 1.0 2 Q96G23 1 +Nuclear import signal receptor activity 0.4177593695630093 0.5434941822754894 0.5867895953954516 1.0 1.0 12 O00410,O00505,Q9Y5L0,Q92973,Q9UI26,Q96P70 6 +Mismatched dna binding 0.4633342426996882 0.5380951056054905 0.5905113912799531 1.0 1.0 6 P54277 1 +Nad binding 0.394786675774274 0.534025507766204 0.5933238863452561 1.0 1.0 30 Q16836,P48735,P50213,O75306,P30837,O75874,Q8N335 7 +R smad binding 0.5075919220165174 0.5316745695962737 0.5949514079508305 1.0 1.0 4 Q9UPN9 1 +Transcription coregulator binding 0.4106493816560156 0.5308424225455365 0.5955279798223716 1.0 1.0 24 Q9UQB8 1 +Rna cap binding 0.4130341303487438 0.5276404473034908 0.5977489141465977 1.0 1.0 11 Q96F07,Q6PKG0,Q7L576,O15371,Q8TEQ6,Q09161 6 +Microtubule motor activity 0.4166954632339187 0.5269717642118372 0.598213196558149 1.0 1.0 15 Q86Y91,Q96Q89,Q02241,Q9BW19 4 +Rna polymerase ii general transcription initiation factor activity 0.5933612883888515 0.5254713927343158 0.5992555350448197 1.0 1.0 3 P29083 1 +Voltage gated cation channel activity 0.7975016436554896 0.5164693903756109 0.6055266122924994 1.0 1.0 2 Q00535 1 +Voltage gated calcium channel activity 0.7975016436554896 0.5164693903756109 0.6055266122924994 1.0 1.0 2 Q00535 1 +Ccr5 chemokine receptor binding 0.7968441814595597 0.5146428325256127 0.6068026283034529 1.0 1.0 2 P48681 1 +Lipopolysaccharide binding 0.4400344168173741 0.51326672666304 0.6077647556147199 1.0 1.0 7 P25786,P28070 2 +Phosphatidylinositol phosphate binding 0.3874382398863524 0.5127841040749098 0.6081023503131748 1.0 1.0 31 A1X283,Q13045,O43795,P22059,Q9Y4P8,Q92538,P31749,Q9H4A5 8 +Microfilament motor activity 0.4037284433329473 0.5010266729936671 0.6163523511697246 1.0 1.0 9 O43795,P60660 2 +Structural constituent of synapse 0.4513279394939513 0.4905301110494477 0.6237588278735626 1.0 1.0 6 Q15334,Q16352 2 +N6 methyladenosine containing rna binding 0.4721802264455249 0.485618457953601 0.6272377071418365 1.0 1.0 5 Q7Z739,P22626 2 +Trna guanine methyltransferase activity 0.4129421010776083 0.4694544812219877 0.6387448137600975 1.0 1.0 8 Q13395,P57081 2 +Atp dependent peptidase activity 0.465415587667277 0.4609027892071402 0.6448683505601336 1.0 1.0 5 Q16740 1 +G quadruplex rna binding 0.7767915844838864 0.4602222452376695 0.645356705339933 1.0 1.0 2 Q9H2U1 1 +Trna methyltransferase activity 0.3941629867251389 0.4581505064461497 0.6468443151727921 1.0 1.0 9 Q13395,P57081 2 +Histone h3 methyl lysine 36 demethylase activity 0.7698882314266872 0.4420929092695985 0.6584219752576006 1.0 1.0 2 Q8IUF8 1 +Nucleoside triphosphatase regulator activity 0.3331462145646155 0.4315099210742881 0.6660976404336645 1.0 1.0 74 P80303,O94813,Q9P258,P55010,Q92888,P49770,Q68EM7,P49815,Q15334,Q15276,P21359,Q02818,Q92538,Q9H0E9,Q9P2J5,Q9HCU5,O43924,Q4KMP7 18 +Protein phosphatase regulator activity 0.3918806649138274 0.4100772894609826 0.681749251729038 1.0 1.0 19 P30153,P30154,P78318,Q01105,Q9UPN7 5 +Acetyl coa hydrolase activity 0.7564102564102546 0.4076512503906927 0.6835297323910958 1.0 1.0 2 P42765 1 +Mitogen activated protein kinase p38 binding 0.7554240631163668 0.4051822661363082 0.6853435394388132 1.0 1.0 2 Q99873 1 +Phosphotransferase activity for other substituted phosphate groups 0.4283726766550135 0.4034346172776643 0.6866285247125443 1.0 1.0 6 Q9NRN7 1 +Endodeoxyribonuclease activity 0.3867856723808823 0.4030179150733018 0.6869350452498095 1.0 1.0 12 Q9UQ84 1 +Gtp dependent protein binding 0.4093905645893409 0.3908877700044353 0.6958801943498638 1.0 1.0 7 P60953,Q86YV9 2 +Acetylgalactosaminyltransferase activity 0.5483226273580886 0.3900141206138729 0.6965261053930556 1.0 1.0 3 Q10471 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.5483226273580886 0.3900141206138729 0.6965261053930556 1.0 1.0 3 Q10471 1 +Dicarboxylic acid transmembrane transporter activity 0.4065666316751697 0.3801428611271642 0.7038393711073665 1.0 1.0 7 O75746,P41440 2 +Co smad binding 0.7445759368836443 0.3785005343230274 0.7050587969111086 1.0 1.0 2 Q9UPN9 1 +Nucleocytoplasmic carrier activity 0.382820041489129 0.3708781084372669 0.7107283211135589 1.0 1.0 20 O00410,O00505,P62826,O60684,Q9Y5L0,Q92973,O14980,Q8TEX9,Q9UI26,Q96P70,Q9UIA9,P55060,Q9C0E2 13 +Protein serine threonine kinase activity 0.3113828529178776 0.3644760627893704 0.7155025454714457 1.0 1.0 68 Q9UHY1,P24941,P67870,P17612,P78362,P48729,P50750,Q96KB5,P31751,P78527,Q86UE8,P11802,Q00535,Q13418,P31749,Q8IV63,Q05655,Q13546,P46020,Q15120,Q9Y4B6,Q13555,P42345 23 +Gtpase activator activity 0.2894045820968312 0.3641480561264535 0.7157474530544323 1.0 1.0 45 P49815,Q15334,Q15276,P21359,Q9H0E9,Q92888,Q68EM7,Q9HCU5,Q4KMP7 9 +Sequence specific mrna binding 0.4163846372743155 0.3602660020539719 0.7186482211124547 1.0 1.0 6 P00374 1 +Pre mrna binding 0.3809254197872453 0.3602256652782138 0.7186783831385655 1.0 1.0 17 P14866,P17844,P26368,Q9BWF3,P62995,P22626,Q92879 7 +Cis trans isomerase activity 0.3775530114462846 0.3593836140653986 0.7193081311562746 1.0 1.0 23 O95302,P62942,Q9Y680,Q9NWM8,Q8WUA2,P26885,Q13526 7 +Peptide binding 0.3103762318447864 0.357154616983446 0.7209760586476857 1.0 1.0 68 Q15392,Q9BYT8,Q9NZ08,P21266,Q9UIQ6,P55786,O43731 7 +Double stranded telomeric dna binding 0.4344111037102005 0.3536610676714664 0.723592902748674 1.0 1.0 5 P12956,P13010,P27695 3 +Racemase and epimerase activity acting on carbohydrates and derivatives 0.732084155161079 0.3488952436599463 0.7271679560968565 1.0 1.0 2 Q13630 1 +Poly pyrimidine tract binding 0.3745086634679115 0.3451624078702922 0.7299722782239715 1.0 1.0 13 Q06787,P31943,P26368,Q07666 4 +Protein serine threonine tyrosine kinase activity 0.2935878960247347 0.3442230942145891 0.7306785156819684 1.0 1.0 61 P24941,P17612,Q7Z460,P78362,P48729,P50750,Q96KB5,P31751,P78527,Q05397,Q86UE8,P11802,Q00535,Q13418,P31749,Q9H2G2,Q16513,Q05655,Q13546,Q9Y4B6,Q13555,P42345 22 +Lipid transfer activity 0.3938517199317277 0.3330415886278889 0.7391028901849441 1.0 1.0 7 Q00169,Q14849 2 +Endoribonuclease activity 0.3726896789897752 0.3242936809296127 0.7457157032977795 1.0 1.0 18 O15091,Q9BQ52,Q99575,Q96F86,Q9UQ84,Q9UPY3 6 +D threo aldose 1 dehydrogenase activity 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 P14550,O43488 2 +Alditol nadpplus 1 oxidoreductase activity 0.5192370930614831 0.3121828195695194 0.7549015881069678 1.0 1.0 3 P14550,O43488 2 +Transmembrane transporter binding 0.3517805569987939 0.306521028210389 0.7592079716631424 1.0 1.0 30 Q9HD26,P42858,Q06787,Q96PU5,Q9NRX4,Q96CW1,Q13642,Q8IWX8,P62942,Q8N335,P27695 11 +Four way junction dna binding 0.4181425147317829 0.3019347807813824 0.7627017811318488 1.0 1.0 5 P09429,P52701 2 +Phosphatase regulator activity 0.3660588557376438 0.2999939548801339 0.7641817666963957 1.0 1.0 21 P30153,P30154,P78318,Q01105,Q9UPN7 5 +Estrogen receptor binding 0.362629467498024 0.2967970493182507 0.7666214583299567 1.0 1.0 13 Q969T9,A5YKK6,O43815,Q15648,Q9Y4B6 5 +Amide binding 0.363103666521135 0.2853005881921552 0.7754138622624538 1.0 1.0 99 Q15392,Q9Y680,Q9UIQ6,P55786,P41440,Q9NZ08,P21266,P50747,P40855,Q9BYT8,Q96RQ3,O00763,P26885,Q00169,P11498,P05165,O43813,Q9UM22,O43731 19 +5 3 dna helicase activity 0.4296069597492831 0.2811296176739492 0.77861098522205 1.0 1.0 4 P18074 1 +Translation regulator activity nucleic acid binding 0.2886537809408125 0.2796547781258706 0.7797423762506628 1.0 1.0 63 Q13144,P34897,Q6PKG0,P60228,P24534,Q92616,Q7L2H7,Q15056,Q05639,P55884,Q7Z478,Q9BY44,Q92879,Q9ULC4,Q8NE71,Q9Y262,P49770,Q9Y450,Q9NR50,P55010,Q9UI10,O15371,Q00577,Q14152,Q9UBQ5,P00374,Q14232,P29692,Q92905,O75822,O15372,P34896 32 +Acyltransferase activity 0.2555598740536328 0.2742155066387552 0.7839190121206621 1.0 1.0 48 Q9BWD1,P23786,P68402,Q96G23,O15270,O75448,Q86UY6,Q9H9T3,Q9BXJ9,P11182 10 +Epidermal growth factor receptor binding 0.3894009216589886 0.2699583149162789 0.7871923231748637 1.0 1.0 6 P18085,P62993,Q92600,Q13596,O60749 5 +Virion binding 0.6949375410913811 0.2684519444303997 0.7883514604086612 1.0 1.0 2 Q99816 1 +Oxidoreductase activity acting on ch or ch2 groups 0.693622616699537 0.2658232576391065 0.7903753304360182 1.0 1.0 2 P23921 1 +Anaphase promoting complex binding 0.4963685443211362 0.2572254997048267 0.7970047002009044 1.0 1.0 3 Q12834 1 +Protein kinase a binding 0.3545339683071664 0.2567222780706749 0.7973931723757894 1.0 1.0 15 Q96M27 1 +Rna stem loop binding 0.3576571338464649 0.2542551178432654 0.7992984713852676 1.0 1.0 8 Q06787,O00571,Q96EP5 3 +Tumor necrosis factor receptor superfamily binding 0.4166748084616601 0.2465868911633228 0.805227950663572 1.0 1.0 4 P42224 1 +Sterol transfer activity 0.4160849423598963 0.2450668786053677 0.8064046480917646 1.0 1.0 4 Q14849 1 +Dioxygenase activity 0.3526167165250115 0.24432525285239 0.8069789270587193 1.0 1.0 17 Q32P28,O00625 2 +Phosphatase activity 0.257475256428435 0.2430198346971449 0.8079900321082472 1.0 1.0 51 Q7Z4H3,P78330,Q9NRX4,Q13555,Q9H857,Q969T7,Q9NPH0 7 +Oxidoreductase activity acting on a heme group of donors 0.3673850967306326 0.2424997743777429 0.80839293165978 1.0 1.0 7 Q7KZN9 1 +Glycolipid mannosyltransferase activity 0.4882564975437863 0.2391542263150378 0.8109859949425835 1.0 1.0 3 Q9H553 1 +Hyaluronic acid binding 0.6794871794871846 0.238549299708985 0.8114550830856018 1.0 1.0 2 Q07021 1 +Nad dependent protein deacetylase activity 0.4863531732982421 0.2350257941397954 0.8141887130471805 1.0 1.0 3 Q13547,Q96EB6 2 +Catalytic activity acting on dna 0.3140338648023644 0.2060686945932278 0.8367372520445922 1.0 1.0 81 P33993,Q9UQ84,Q9BXF3,P19447,Q07864,P41440,P40937,P26358,Q9H2U1,P18887,Q9H4L7,Q12873,P18074,O00571,Q96QE3,P12956,O14646,P52701,Q9NRF9 19 +Fibroblast growth factor binding 0.3835090602649015 0.2041636820656783 0.8382255910874608 1.0 1.0 5 Q9BZZ5 1 +Poly a binding 0.3338192143273224 0.2018490343600489 0.8400347465471822 1.0 1.0 11 O14979,O00571 2 +Electron transfer activity 0.2506370067069577 0.199524349922884 0.8418525977775513 1.0 1.0 51 P00390,Q7KZN9,P28331,O75306,Q15526,Q6FI81,P13804,Q9UDW1,P03886 9 +Ligase activity forming carbon nitrogen bonds 0.3407866078437414 0.1986875948397439 0.8425071284447387 1.0 1.0 20 P50747 1 +Acetyltransferase activity 0.3275225150867354 0.1890223061359535 0.8500753341596832 1.0 1.0 29 Q9BWD1,P68402,O75448,P42765,O75600,Q86UY6,Q9H9T3,Q9GZZ1,Q9BXJ9,P11182 10 +Guanyl nucleotide exchange factor activity 0.3266426347153483 0.1855540068409804 0.8527945243016044 1.0 1.0 29 P80303,P18085,Q13144,Q9NR50,Q9P258,Q14232,Q9UI10,P29692,Q9NPQ8,Q9Y2L1,Q92974,Q02818,Q92538,Q92888,O95714,Q9HCU5,P49770 17 +Sulfur compound transmembrane transporter activity 0.3604344963791995 0.1852819116785765 0.8530079247844413 1.0 1.0 6 O00400,Q02978,Q70HW3,Q8TB61,Q9UBX3 5 +Nuclear export signal receptor activity 0.336469341261861 0.1846623245662758 0.8534938985285441 1.0 1.0 8 P62826,O14980,Q9UIA9,P55060,Q9C0E2 5 +Nucleoside diphosphatase activity 0.6476002629848738 0.1837980145851351 0.8541719137366495 1.0 1.0 2 Q8WVQ1 1 +1 phosphatidylinositol binding 0.3748779248969074 0.1826711469199585 0.8550560562159875 1.0 1.0 5 Q8WTV0,P11171,Q13492 3 +Deoxyribonuclease activity 0.335987013973671 0.1823381524506613 0.8553173591890522 1.0 1.0 18 Q9UQ84 1 +Thiol oxidase activity 0.4590595198947571 0.1806217342719183 0.8566644949890931 1.0 1.0 3 Q6ZRP7,Q96HE7 2 +Fatty acid binding 0.3466233538412254 0.1795865338413662 0.857477177237074 1.0 1.0 7 Q15067,Q00169 2 +Solute cation symporter activity 0.321961636767346 0.1764890590682919 0.8599097433701146 1.0 1.0 9 Q15043,Q96ES6 2 +Exopeptidase activity 0.3186896846892406 0.1733299426096147 0.8623920890810366 1.0 1.0 31 Q99829,Q96KP4,Q7Z2K6,Q9NZ08,Q13867,O75844,Q9HB40,Q9H4A4,Q8IYS1,Q9UIQ6,P55786 11 +Oxidoreductase activity acting on nad p h 0.3251175002994009 0.1650437524757262 0.8689095447403774 1.0 1.0 27 P28331,P03886,O95831,Q7KZN9 4 +Rage receptor binding 0.6314924391847418 0.159769684182946 0.8730625057854473 1.0 1.0 2 P09429 1 +Protein phosphorylated amino acid binding 0.3207668208860282 0.1587991473104332 0.8738271206345014 1.0 1.0 11 P22681 1 +Single stranded telomeric dna binding 0.3472903259243193 0.1515607376663252 0.8795334023843737 1.0 1.0 6 P15927,P27694,P22626,P09651 4 +Ubiquitin binding 0.3169053829527412 0.1488109933751591 0.8817027757725404 1.0 1.0 29 O60784,Q5TDH0,Q92783,Q96EY5,Q96FW1,O95071,Q9H4L7 7 +Quinone binding 0.3595383414242051 0.1474971570614928 0.8827396235251905 1.0 1.0 5 O75306 1 +Protein carrier chaperone 0.3092942907346291 0.1370235910168882 0.8910121480508004 1.0 1.0 9 P40855 1 +Heat shock protein binding 0.2393193526425447 0.1351012470089836 0.8925318242482498 1.0 1.0 47 O60884,P42858,Q9UHD1,Q12907,Q00535,Q13451,P31948,P37198,O95801,Q6W2J9,P49815,Q99615,Q99543,P31689 14 +Nuclear receptor binding 0.2717128370211938 0.132762149304953 0.8943814897854165 1.0 1.0 41 Q9UIF9,A5YKK6,Q9Y4B6,Q9NVC6,P17844,P42224,O75448,O43815,Q93074,O14497,Q15648,O43707,Q02790,Q969T9,Q9NPJ6,Q9H0E9,Q9Y2X0,Q96T76 18 +Spectrin binding 0.3514313919052455 0.1305062149558555 0.8961659373731234 1.0 1.0 5 Q12955,P11171,P35611,Q13561 4 +Cyclin binding 0.3110429226473298 0.1291718172693264 0.8972216959178008 1.0 1.0 11 P12956,P11802,Q9BWF3 3 +Hsp90 protein binding 0.3180193136765862 0.125906512876981 0.8998059271764265 1.0 1.0 17 Q9UHD1,Q00535,O95801,P31948,P49815 5 +Exonuclease activity 0.3032554037519375 0.1253800263547698 0.9002226999862635 1.0 1.0 32 Q9GZR2,Q9UNK9,Q9UQ84 3 +Thioesterase binding 0.4245786860786091 0.1250337536780579 0.9004968284404553 1.0 1.0 3 P60953 1 +Dna apurinic or apyrimidinic site endonuclease activity 0.3575657894737033 0.1201601093386978 0.9043563168962252 1.0 1.0 4 P78549,P27695,P23396 3 +Laminin 1 binding 0.596318211702831 0.1156996903711724 0.9078905516531586 1.0 1.0 2 O94813 1 +U4 snrna binding 0.3316433407312728 0.1155011776082281 0.9080478871283886 1.0 1.0 6 O43172 1 +Bubble dna binding 0.5956607495068991 0.1149831730614656 0.908458459525502 1.0 1.0 2 P09429 1 +Death receptor binding 0.5940170940170959 0.1132086630638509 0.9098651276921756 1.0 1.0 2 Q13546 1 +Sirna binding 0.3519140441548247 0.1109008546025501 0.91169496790913 1.0 1.0 4 Q9UPY3 1 +Proteasome activating activity 0.3291639236339724 0.1102032130362119 0.9122482141624756 1.0 1.0 6 P62195,P62191,P43686,P62333,P17980 5 +Wd40 repeat domain binding 0.3491456033446601 0.1065460847337807 0.9151490931406316 1.0 1.0 4 Q96K76 1 +Translation activator activity 0.3486842105263309 0.1058318220836684 0.9157157881923684 1.0 1.0 4 Q6PKG0,Q7Z478,Q9H074 3 +Amp binding 0.3268597761685347 0.1053826524258406 0.9160721807695658 1.0 1.0 6 P54619,P08237,P07741,P17858,P06737 5 +Structural constituent of eye lens 0.4057875698783273 0.1008861178134393 0.9196408632591644 1.0 1.0 3 P08670,Q99797 2 +Poly purine tract binding 0.3058260783945312 0.1000019368512933 0.920342787769981 1.0 1.0 14 Q06787,Q96EP5,O14979,O00571,Q07666 5 +Class i dna apurinic or apyrimidinic site endonuclease activity 0.5775805391189919 0.0967598500861713 0.9229171092573036 1.0 1.0 2 P78549 1 +Toxic substance binding 0.5759368836291845 0.0952420335744842 0.924122583748977 1.0 1.0 2 Q9H814 1 +Deoxynucleoside kinase activity 0.5749506903352968 0.0943421994875478 0.9248373290377336 1.0 1.0 2 P04183 1 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.3034734000473418 0.0863337382667643 0.931201119331018 1.0 1.0 25 Q9UNK9,Q9UQ84 2 +Atp transmembrane transporter activity 0.3239590864409568 0.0812595823856691 0.9352355162342896 1.0 1.0 5 O43808 1 +Syntaxin 1 binding 0.3827688260440629 0.076918693882347 0.9386882260365524 1.0 1.0 3 O75150,O00186 2 +Adp ribose diphosphatase activity 0.5512820512820409 0.0751060817436035 0.9401303089630486 1.0 1.0 2 Q9UKK9 1 +Mrna 5 utr binding 0.3004994141945123 0.073115521159957 0.9417141906168792 1.0 1.0 21 O60506,P34897,Q9H2U1,P34896 4 +Opsonin binding 0.3236396222912088 0.0718964200609059 0.94268433905615 1.0 1.0 4 Q07021 1 +Low density lipoprotein particle receptor binding 0.287353615300949 0.0714678470090055 0.9430254134720644 1.0 1.0 10 Q15036,O43813,Q96CW1,P31689 4 +Signal recognition particle binding 0.3171132349758396 0.0709740256489877 0.9434184278745528 1.0 1.0 5 Q9UHB9 1 +Nuclear receptor coactivator activity 0.2991737338862257 0.0700139991892371 0.9441825172398212 1.0 1.0 22 O75448,Q86X55,Q9NPJ6,Q93074,Q15648,O43707,Q9H0E9,Q9NVC6,Q99816 9 +Modified amino acid binding 0.2980275198714303 0.0668043765407492 0.946737439219548 1.0 1.0 21 Q8WTV0,P41440,Q99829,O60678,O43813,P21266 6 +Metal cluster binding 0.2863454229816106 0.0586524110558193 0.9532289645155094 1.0 1.0 30 Q07864,Q9Y5Y2,P28331,O75306,P18074,Q9H9T3 6 +Translation initiation factor activity 0.2670105866121253 0.0565486181333686 0.9549047657888804 1.0 1.0 37 Q13144,P60228,Q7L2H7,Q15056,P55884,Q7Z478,Q9BY44,Q9ULC4,Q9Y262,P49770,Q9NR50,P55010,Q9UI10,O15371,Q14152,Q9UBQ5,Q14232,Q92905,O75822,O15372 20 +1 acylglycerophosphocholine o acyltransferase activity 0.5180802103878901 0.055085259181831 0.9560705397818848 1.0 1.0 2 Q8NF37 1 +Non membrane spanning protein tyrosine phosphatase activity 0.5147928994082713 0.0534962622909896 0.9573365086465986 1.0 1.0 2 P24666 1 +Phosphofructokinase activity 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 1.0 3 P08237 1 +Fructose 6 phosphate binding 0.3498732999186978 0.052336590859365 0.958260497966249 1.0 1.0 3 P08237 1 +Calcium ion binding 0.291658879669832 0.0489112323359793 0.9609900374675152 1.0 1.0 87 P04350,P98155,Q9Y680,P22681,Q15293,Q14257,O95302,P80303,P60660,P41208,Q9BRK5,Q14574,Q02818,P33908,O43852,Q99829,Q9NWM8,P19022,Q9UM22,Q08554,P48960 21 +Magnesium ion transmembrane transporter activity 0.3387043735613311 0.0462460597425228 0.9631141313577088 1.0 1.0 3 Q8IUH4,Q8N4V1 2 +Peptide hormone receptor binding 0.4950690335305593 0.0452624669039339 0.9638981038319296 1.0 1.0 2 Q06124 1 +Hormone receptor binding 0.4950690335305593 0.0452624669039339 0.9638981038319296 1.0 1.0 2 Q06124 1 +Dynein light intermediate chain binding 0.4894806048652079 0.043304219624984 0.9654590276052316 1.0 1.0 2 Q14204 1 +Cation transmembrane transporter activity 0.2605028600614087 0.0424226334587987 0.9661617856975424 1.0 1.0 72 Q15043,Q96ES6,Q7KZN9,P21283,O43772,P06756,Q00535,Q96NB2,Q15526,Q8NEW0,Q9HD20,O43808,Q93050,Q8NE86,Q9UDW1,Q9Y487 16 +Oxidoreductase activity acting on a sulfur group of donors 0.2861891057906978 0.041874414863673 0.9665988124839896 1.0 1.0 25 Q96JJ7,Q9UHG3,O95881 3 +Neurexin family protein binding 0.4822485207100445 0.0409928023694465 0.9673016339177956 1.0 1.0 2 O00560 1 +Histone serine kinase activity 0.4809335963181972 0.0405983581100147 0.9676160931175728 1.0 1.0 2 Q99986 1 +Protein adp ribosylase activity 0.4783037475345046 0.0398324345105124 0.968226717742843 1.0 1.0 2 Q7Z2W4 1 +Beta tubulin binding 0.2833129108425796 0.0393208092283066 0.9686346160794476 1.0 1.0 16 O75381,Q9NVJ2,P42858 3 +Translation factor activity rna binding 0.2249990198862955 0.0371119042650206 0.9703957803371296 1.0 1.0 55 Q13144,P60228,P24534,Q92616,Q7L2H7,Q15056,Q05639,P55884,Q7Z478,Q9BY44,Q9ULC4,Q8NE71,P49770,Q9Y450,Q9NR50,P55010,Q9UI10,O15371,Q14152,Q9UBQ5,Q14232,P29692,Q92905,O75822,O15372 25 +Tau protein kinase activity 0.3131671091375851 0.035855356767364 0.9713976930969768 1.0 1.0 3 Q00535 1 +Oxidative phosphorylation uncoupler activity 0.458251150558837 0.0349195120434185 0.972143921739936 1.0 1.0 2 P12235 1 +Nucleobase transmembrane transporter activity 0.458251150558837 0.0349195120434185 0.972143921739936 1.0 1.0 2 P12235 1 +Intramolecular transferase activity phosphotransferases 0.279739953750863 0.0333246628737525 0.9734156865503693 1.0 1.0 4 O95394,Q96G03 2 +Phospholipase d activity 0.4483892176199786 0.0330367179998913 0.9736453068827996 1.0 1.0 2 P09601 1 +Inorganic diphosphatase activity 0.4220907297830341 0.0293819913825809 0.976559935398878 1.0 1.0 2 Q9H2U2 1 +Ribonucleoprotein complex binding 0.2835053940644153 0.0284512519103301 0.9773022476122732 1.0 1.0 86 P17844,O60678,Q92616,Q9BSH4,Q96J02,Q9UHB9,P98179,Q96D46,Q06787,Q07021,O95400,O14744,O76094,Q7Z739,O94822,O00571,P57678,Q8TEQ6,Q9BXJ9,Q9UBQ5,Q99543,Q8IWS0,O60828,P42345 24 +Bhlh transcription factor binding 0.3698224852070975 0.0260290712977618 0.979234150759873 1.0 1.0 2 Q96EB6 1 +Cardiolipin binding 0.3372781065088727 0.0253233945393437 0.9797970137690248 1.0 1.0 2 O60313 1 +G protein beta gamma subunit complex binding 0.2744323790720757 0.0234837398729327 0.9812644086108144 1.0 1.0 5 Q14344,P63096,P08754,P41208 4 +Rna methyltransferase activity 0.2769926637127428 0.022736505492637 0.981860456183157 1.0 1.0 18 Q13395,Q96P11,Q8N1G2,P57081 4 +Methyl cpg binding 0.2636568174484369 0.0209883038856162 0.9832549857692194 1.0 1.0 10 O14744,P26358,Q9BQA1,Q99873,Q9UFC0 5 +Active ion transmembrane transporter activity 0.2347654220912112 0.0196493715318994 0.9843230786358548 1.0 1.0 42 P20674,Q15043,Q96ES6,P41440,Q7KZN9,P21283,Q15526,Q96QD8,Q9HD20,Q9UDW1,P12236 11 +Oxidoreduction driven active transmembrane transporter activity 0.2716219031133199 0.0196034818847557 0.9843596862255692 1.0 1.0 29 Q7KZN9,P28331,O75306,Q9UDW1,P03886 5 +Ribonuclease activity 0.2453253373194981 0.0168710957026376 0.9865394517727232 1.0 1.0 39 O15091,Q9BQ52,Q9UNK9,Q99575,Q96F86,Q9UQ84,Q9Y3Z3,Q9H0D6 8 +Magnesium ion binding 0.2484897637367967 0.0167790894832503 0.9866128517247424 1.0 1.0 70 P17612,P48735,P78330,P50213,Q9NRN7,O75874,Q9H773,Q969T7 8 +Protein transporter activity 0.2710821622183808 0.0153319395796655 0.987767361375173 1.0 1.0 16 Q99595,O60830,Q9NS69 3 +Protein kinase activity 0.2698130718127299 0.0057990273878735 0.9953730715125032 1.0 1.0 83 Q9UHY1,P24941,P67870,P17612,P78362,P48729,P50750,Q96KB5,P31751,P78527,Q05397,Q86UE8,P11802,Q00535,Q13418,P22392,P31749,Q8IV63,Q05655,Q13546,P46020,Q15120,Q9Y4B6,Q13555,P42345 25 +Omega peptidase activity 0.2665472687676603 0.0049990567850874 0.9960113463857292 1.0 1.0 27 Q96RU2,Q9UPU5,Q93008,Q96K76,Q6GQQ9,Q92890,Q93009,Q96FW1,Q99496 9 +Mirna binding 0.2622691463778469 0.0003674816147728 0.9997067920997932 1.0 1.0 16 P22626,Q9UGR2 2 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f5268de7ce46ed4ba9baa38a9207bdb398f785e1 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "3 phosphoadenosine 5 phosphosulfate binding", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin activated receptor activity", "Activin binding", "Activin receptor activity type i", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Ap 2 adaptor complex binding", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel activator activity", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase activity involved in apoptotic process", "Cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidine deaminase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor activity", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxycytidine deaminase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix constituent conferring elasticity", "Extracellular matrix protein binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanosine diphosphatase activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Ige binding", "Immune receptor activity", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inhibin binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate kinase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor i binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interferon receptor activity", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide 1 2 alpha mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neuregulin binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neuropeptide binding", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol n acetylglucosaminyltransferase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Platelet derived growth factor receptor binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion antiporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Potassium proton antiporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein hormone receptor activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Superoxide generating nadph oxidase activator activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein serine threonine kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRIX1", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPV", "CEP290", "CEP44", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM50A", "FAM83D", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3L", "GOPC", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MVB12A", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFS1", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABGAP1", "RABGGTB", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMS", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNE2", "TAB1", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM165", "TMEM192", "TMEM201", "TMEM206", "TMEM30A", "TMEM43", "TMEM59", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TST", "TSTA3", "TTC1", "TTC26", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VRK1", "VRK3", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF346", "ZNF512B", "ZNF622", "ZNF638", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCF1", "ACAA2", "ACACB", "ACAT2", "ACOX1", "ACP1", "ACP6", "ACTN4", "ADD1", "ADGRE5", "AHCYL1", "AIFM1", "AKR1A1", "AKR7A2", "AKT1", "AKT2", "ALDH1B1", "ALG2", "ANGEL1", "ANK3", "ANKS1A", "ANXA2", "AP2M1", "APEX1", "API5", "APRT", "ARF4", "ARHGAP17", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH2", "ARL8B", "ARMT1", "ATAD5", "ATG4B", "ATP13A1", "ATP6V0A1", "ATP6V0A2", "ATP6V1C1", "BAIAP2", "BAZ2A", "BCOR", "BLMH", "BRD7", "BRD8", "C1QBP", "CALU", "CAMK2G", "CANT1", "CAPN1", "CARM1", "CBL", "CCDC22", "CCNA2", "CCNB2", "CD2BP2", "CDC20", "CDC42", "CDH2", "CDK2", "CDK4", "CDK5", "CDK9", "CECR2", "CELF1", "CERS2", "CETN2", "CHD1", "CHD3", "CHERP", "CHORDC1", "CIAPIN1", "CIRBP", "CLASP1", "CLPP", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNOT9", "COPS4", "COPS5", "COPS6", "COX15", "COX5A", "CPNE1", "CPT2", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CTR9", "CYFIP1", "CYFIP2", "CYP51A1", "DAZAP1", "DBT", "DCAF1", "DCTN2", "DCTPP1", "DCUN1D4", "DDI2", "DDX1", "DDX3X", "DDX5", "DHCR24", "DHCR7", "DHFR", "DHX29", "DHX36", "DICER1", "DIS3", "DNA2", "DNAJA1", "DNAJA2", "DNAJC2", "DNAJC7", "DNMT1", "DOHH", "DSC1", "DSC3", "DSP", "DYNC1H1", "EDC3", "EEF1A2", "EEF1B2", "EEF1D", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B3", 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1.0 0.0711332726649859 0.1297953400165049 0.2953213972625715 0.5136086765128763 +Neoplasm of the parathyroid gland 3 6 2.378417031512424 0.0173871492701445 1.953883495145631 5.334951456310679 0.1934336223413519 0.3476850576062903 1.202872559415007 0.967652422740595 1.374245033457798 0.3050616837572409 1.0 1.0 0.1216867716169547 0.0002295520479336 0.0032789531174172 +Parathyroid adenoma 3 6 2.378417031512424 0.0173871492701445 1.953883495145631 5.334951456310679 0.1934336223413519 0.3476850576062903 1.202872559415007 0.967652422740595 1.374245033457798 0.3050616837572409 1.0 1.0 0.0969098674411308 7.992208848006033e-05 0.0012094246202506 +Abnormality of the parathyroid morphology 3 6 2.378417031512424 0.0173871492701445 1.9951456310679612 5.54126213592233 0.174968201326553 0.3509598237346392 1.2385301843824976 1.1216087437262623 1.374717808134014 0.307204091695738 1.0 1.0 0.1457909390967105 0.0005168566519776 0.0069721115041673 +Metaphyseal chondrodysplasia 0 5 2.307125152807464 0.0210478441110031 1.2524271844660195 4.655339805825243 0.4492363491908326 0.5181802335870666 1.4562783167925129 0.7585407753265292 0.8814120847554563 0.3157143289841511 1.0 0.0479914252810258 0.088498207465679 0.2080716609140995 0.3814478232013164 +Abnormality of the metaphysis 15 51 2.2953631097478877 0.0217123236388856 9.87621359223301 51.49514563106796 0.3562011438392169 0.6166342982450355 4.530020385411355 8.226317920685393 0.7780483709827255 0.3214835918572445 1.0 0.0071908695914616 0.0569316885329123 0.0709567352007072 0.2019275205279745 +Peripheral axonal neuropathy 10 47 2.277670232499076 0.0227462325663276 13.890776699029129 56.6626213592233 0.647996206639266 0.5297865267121298 5.546380992609976 6.858150910061315 0.9851361073340408 0.3701043540632976 1.0 0.0277741900197473 0.0351174006609635 0.1968800611047588 0.0498589464872495 +Thin ribs 4 12 2.274854621424029 0.0229146523045908 3.4101941747572817 12.966019417475728 1.1546097093245242 0.318018636886438 1.686379750034164 1.4240686548069037 0.806693252185275 0.2897104943533539 1.0 0.0112943240362007 0.0369002586596571 0.039693045522763 0.0177668085937166 +Sarcoma 20 63 2.269539561958894 0.0232355342276473 13.49271844660194 59.24757281553398 0.2024053329324482 0.5878401261352646 7.66928341789692 5.604858236953758 0.9869836607136444 0.3372231979111714 0.0504179803987023 0.1349531687426338 0.0327093700334769 0.0032559561577733 0.0198815217923032 +Abnormal greater sciatic notch morphology 0 6 2.267964967073264 0.0233313420140743 1.5266990291262137 4.774271844660194 0.5311073615188446 0.5175259822444115 1.160333805628576 1.2676015896874502 0.8322004072094659 0.3157464750199098 1.0 0.0802348466038066 0.1457909390967105 0.3274785952656331 0.558210992768628 +Exostoses 2 6 2.263999294448308 0.023574158172787 1.8737864077669903 4.565533980582524 0.1227309696596917 0.3298370080715785 1.065155184012566 0.8232521681359034 1.4140930420981814 0.2989667883126048 1.0 1.0 1.0 0.0401162059364398 0.0253286122308114 +Rhizomelia 3 12 2.236713261126269 0.0253050867222637 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.017927153547519 0.0014522342124754 0.0086508387153309 0.0210689240618057 0.0196310740143902 +Metaphyseal dysplasia 6 12 2.226187777323104 0.0260016063204464 2.6189320388349513 10.4247572815534 0.485435274486908 0.5421266798600373 2.0908795996507425 1.593880496830027 0.7911796361418049 0.3013045749035116 1.0 0.0060718409625537 0.0203452581708214 0.0171165739281897 0.0240418083159873 +Barrel shaped chest 2 5 2.219544080739932 0.0264497317761143 1.674757281553398 4.473300970873787 1.1869997902874323 0.2609030887925388 1.0385967424919742 0.917344085691108 0.8975397916941404 0.2534223349008651 1.0 3.8887516945815136e-05 0.0002566277436278 0.0036456852425391 0.0253286122308114 +Coxa vara 2 15 2.2088703740362456 0.0271836583803024 4.310679611650485 13.54126213592233 0.853738655548226 0.4218003203060939 1.9720332330132235 1.9928869528934432 0.8140335419312188 0.3116542205645756 1.0 0.0171096007657598 0.0546703746725879 0.0679390116065291 0.1241504436951967 +Sensory axonal neuropathy 5 12 2.1939863359128915 0.028236391886963 3.9975728155339807 14.679611650485436 0.7278248103953019 0.4694895664907109 2.2409459540492587 2.061969989484369 0.8093416738396336 0.3127535543746148 1.0 0.0087935329278829 0.0290533032515491 0.0284164475709735 0.0019442034931097 +Increased connective tissue 2 8 2.184507219329748 0.0289249973772118 2.5145631067961167 7.502427184466019 0.8156544766596637 0.4080201432400869 1.4337409663669696 0.673704389121222 0.9233752682577614 0.3237190879475042 1.0 0.0038211367015083 0.012986178174142 0.0699562770043831 0.0567666846908377 +Keratoconjunctivitis 5 10 2.167123409393812 0.0302254453942438 2.3276699029126213 9.567961165048544 0.3066198135368672 0.5403280269018721 1.572491501440906 1.0109798757499866 0.802064137752686 0.2743185917111204 1.0 0.0082126449787597 0.002103630595289 0.0036453695305493 0.0016044613820578 +Deformed sella turcica 0 5 2.164579191684168 0.0304199259549866 1.449029126213592 4.361650485436893 0.6519584745232953 0.4108786670869809 1.0702617541763486 1.191712968868623 0.98030484078304 0.3007326817007539 1.0 0.0573151884822011 0.105244719915057 0.2441928670926492 0.4381421775371425 +Fragile nails 5 9 2.157171122789361 0.0309923335931217 2.4684466019417477 9.5873786407767 0.0151376572396068 0.5864940846861973 1.826576859551132 1.2086403828590886 0.7932403783046267 0.2802937979561912 1.0 1.0 1.0 0.4421391613279137 0.0054045102044807 +Cone shaped epiphysis 1 10 2.150770518734648 0.0314943171481105 3.2063106796116503 11.87135922330097 0.0642421494677637 0.5491292316029612 1.8258284409306336 3.3100985667263836 0.8697998682944144 0.2760577132687285 1.0 0.0358926009784828 0.1085884617962232 0.4122461959787835 0.7870659710590884 +Abnormal sputum 1 6 2.149733126373236 0.0315763305653153 1.6844660194174756 6.092233009708738 0.4794626909688891 0.5185854502328194 1.4869828239587144 1.2526623546800988 0.8013388208691827 0.29826424661196 1.0 0.1988423464133734 0.3414395457848725 0.2780679030233111 0.6302880920877445 +Abnormality of the pulmonary veins 0 6 2.140629377609075 0.0323039377659841 1.2135922330097086 6.669902912621359 0.9535622979003926 0.3793496965363341 1.175399006302687 0.7806936113776552 0.7920022166500139 0.2937792263138297 0.0136623349293318 0.1583124314184509 0.2772677301394485 0.5584705395371538 0.814263224242388 +Broad palm 2 9 2.1013269180962846 0.0356122783790722 1.9951456310679612 6.810679611650485 0.8447038493260335 0.3335088320973898 1.1679272687137603 1.380545313769426 0.9814334548432692 0.2724793488094146 1.0 0.0001834080308804 0.0011757375379861 0.0152311499254605 0.0207837723558428 +Impaired tactile sensation 3 8 2.09647100453013 0.0360404294494198 2.0800970873786406 7.844660194174757 0.3974848446712213 0.5051291165171002 1.725280894617257 1.4698080024763955 0.8897962544432779 0.3006087956437986 1.0 0.0051137089586154 0.0172318932328863 0.090392334082392 0.0178122423635135 +Acanthosis nigricans 4 9 2.0872504886210983 0.036865497761076 2.8349514563106797 10.186893203883496 0.2792290795225376 0.5702847415694762 1.8333326192453845 1.305895169023182 0.7968055332294672 0.2940984460026474 1.0 0.0100088432903632 0.0328837758174392 0.0338089806640789 0.0551715629817244 +Toxemia of pregnancy 1 7 2.0826253348822488 0.0372853880552943 1.4878640776699028 5.800970873786408 1.2181595126321945 0.2438445067902855 1.0938256996143263 0.5566883958063523 0.8280220660434614 0.2316195823412623 1.0 0.0015075035399645 0.0052264902137193 0.0299842123439505 0.1061326514653331 +Aplasia hypoplasia of the capital femoral epiphysis 1 6 2.0806061478055047 0.0374699707251864 1.4344660194174756 5.019417475728155 0.4404435176817264 0.4586115848866851 1.1692153440192188 1.5902041300501577 0.9972055316061226 0.3108875242391429 1.0 0.0573151884822011 0.105244719915057 0.0299842123439505 0.1061326514653331 +Broad neck 4 12 2.068491266892198 0.0385938509743668 3.682038834951456 11.478155339805824 -0.3887278439111738 0.5542251843787884 1.7813400972810238 1.411467767050648 0.7625543498219208 0.2878212872018439 1.0 0.0981765691424607 0.0157589231505245 0.0012089286033311 0.0024159014972712 +Abnormality of the alveolar ridges 2 8 2.0666839896492823 0.0387639407685649 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.0113302238096159 0.1330370821365251 0.0290533032515491 0.0284164475709735 0.0447759508663171 +Disproportionate short limb short stature 6 20 2.054196924216117 0.0399566359890826 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.0264152844680412 0.0003307976495693 0.0035169668949728 0.0046753190270427 0.0137630867634167 +Limb undergrowth 8 47 2.053532415231819 0.0400209692686341 10.648058252427184 51.10436893203884 0.3980398713744312 0.5752346762319336 4.664982243954684 7.303495661229484 0.9215304205365352 0.3350258300048305 0.0695213873936636 0.0595462588150643 0.2357636696185375 0.127647101005292 0.349106463845159 +Peripheral axonal degeneration 14 62 2.040501568767742 0.0413003949459103 16.691747572815533 71.19902912621359 0.6211832637355972 0.5650732986012978 6.425044282599762 8.4263916789636 0.8780908495791551 0.3675751486040735 1.0 0.008364172404603 0.0176508716795779 0.1778888230379755 0.0100610131583669 +Cerebral palsy 3 10 2.0365434903501383 0.0416958106369216 3.3155339805825244 10.322815533980584 0.327647367871302 0.4350980952086785 1.85452777238683 1.3053898108248347 1.2120349360022649 0.3317594862887821 1.0 1.0 1.0 0.0041532938437691 0.0447759508663171 +Broad foot 1 10 2.035050441122648 0.0418457978532167 2.3300970873786406 9.016990291262136 0.256328891212772 0.5237546105785787 1.7131039762059068 1.5223903885177978 0.8992937610865464 0.290191176620823 1.0 0.007105321595433 0.0236743481254358 0.1199061038889744 0.3461347832433586 +Retinal telangiectasia 2 5 2.03456231304375 0.0418949326762714 1.3106796116504855 5.007281553398058 0.8088648966265131 0.3483026313211161 1.0430456357811864 1.087191709833904 1.1553193033520868 0.3106693264231038 1.0 1.0 0.1614955872519625 0.0699562770043831 0.0567666846908377 +Hemoptysis 1 5 2.032802693410382 0.042072460923793 1.2888349514563109 4.567961165048544 0.5103110462647967 0.5100711981425967 1.2013631424109217 0.954164463672047 0.8243072722468673 0.2972005428480252 1.0 0.1287528218161406 0.2287042177685609 0.1354407626259564 0.3804196908895423 +Hypoplasia of the odontoid process 1 6 2.0038172231607687 0.0450896431850713 1.7135922330097086 5.849514563106796 0.7084033927132167 0.339821590839337 1.2308769108438145 1.328066978835538 1.0561070911915744 0.2674195088010785 1.0 0.0030581061915538 0.0104522439456993 0.0573204241328388 0.1881865161038274 +Cystic hygroma 2 9 1.9998060939806976 0.0455212063036132 1.9975728155339805 7.694174757281553 0.4180253768272444 0.582128414388285 1.6858906009834405 1.3177890606219358 0.6893959425890075 0.2803717296643887 1.0 0.1457663642848915 0.256836792362671 0.1676876460836239 0.1878725565212675 +Hyperthyroidism 6 10 1.9973803799557308 0.0457838775197549 2.75 9.70873786407767 0.3199481022334094 0.5629027296020321 1.9316286704199517 1.8242224994230456 0.7961631360799964 0.2914238511942971 1.0 1.0 1.0 0.4550284836256487 0.0314378180168525 +Premature ventricular contraction 3 7 1.9968505051473235 0.0458414252333274 1.480582524271845 6.645631067961165 0.3887689762072841 0.3497972460308874 1.4234893714961696 0.5447501786076202 1.2366408357670695 0.2803988641190083 1.0 0.0338360956076009 0.0627953497561382 0.0003950794296944 0.0001491176280431 +Abnormality of the odontoid process 1 7 1.987663653107217 0.0468489013303301 1.8883495145631068 6.849514563106796 0.4809480703698225 0.3910181029813887 1.283638712356007 1.328066978835538 1.0241378212028085 0.2619757585976807 1.0 0.0042324529563037 0.0143432947155656 0.0765832806915382 0.2406368082364221 +Enlarged thorax 7 19 1.981914167734195 0.0474888479818689 3.851941747572816 16.553398058252426 0.6878502324489157 0.4991384851328346 1.9804680030663864 2.795551790331099 0.7693523377829645 0.315559863824272 1.0 0.002071073147083 0.0121055345903325 0.0011797232246237 0.002684649860036 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f9d75eaf43f80be16aeb27e39552bc812948d72d --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 4611, + "title": "Average number of proteins per term", + "value": 23.0769898069833 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4c1c853bec80a56e70e7a3182676904582347a5f --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3216936881375b84e79643bd5c0c3fcb786ca5bc --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1387 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lissencephaly 0.5181070486878864 2.7579143435876547 0.0058171438679768 0.9999999999979252 0.92074266825373 49 P23786,Q15392,P98155,O43776,Q16625,P07942,Q9H9S5,Q9BV10,P57081,Q9Y5P6,P13804,P78527,Q96EK5,Q9Y487 14 +Abnormality of tibia morphology 0.7989192703986442 2.4754911578661933 0.0133053056320511 1.0 0.92074266825373 14 Q32P28,Q7RTS9,O95831 3 +Cupped ear 0.7854876535692281 2.425717659066351 0.0152781511364123 1.0 0.92074266825373 15 Q15392,P78318,Q2TAL8,Q93074,O60828,Q6W2J9,P52788 7 +Neoplasm of the parathyroid gland 0.8844879122302448 2.3784170315124236 0.0173871492701445 1.0 0.92074266825373 6 P49815,P21359,P48735 3 +Parathyroid adenoma 0.8844879122302448 2.3784170315124236 0.0173871492701445 1.0 0.92074266825373 6 P49815,P21359,P48735 3 +Abnormality of the parathyroid morphology 0.8844879122302448 2.3784170315124236 0.0173871492701445 1.0 0.92074266825373 6 P49815,P21359,P48735 3 +Abnormality of the metaphysis 0.47493926174861 2.2953631097478873 0.0217123236388856 1.0 0.92074266825373 51 Q96MF7,Q14739,Q07864,O95831,P48735,Q13126,A1X283,Q7RTS9,Q99575,Q2TAL8,O75874,Q9H1A4,Q9NUQ7,Q9NPE3,P36776 15 +Peripheral axonal neuropathy 0.4792196876483068 2.277670232499076 0.0227462325663276 1.0 0.92074266825373 47 Q15813,Q15067,O95831,P07384,P34897,Q6DD88,Q15046,P22626,P39210,P03886 10 +Thin ribs 0.7616105051702303 2.2748546214240295 0.0229146523045908 1.0 0.92074266825373 12 Q32P28,O14802,O75844,O95831 4 +Sarcoma 0.5044345548755625 2.269539561958894 0.0232355342276473 1.0 0.92074266825373 63 P61313,Q15392,P48735,Q13126,Q01844,P18077,Q9UPY3,Q9H1A4,P46783,P21359,Q12824,P25054,Q92804,O75874,P31749,Q05655,P08708,Q99496,P52701,P49815 20 +Exostoses 0.8570073084852083 2.263999294448308 0.023574158172787 1.0 0.92074266825373 6 O75874,P48735 2 +Gingival fibromatosis 0.932939743972831 2.2543880931491365 0.0241717636920144 1.0 0.92074266825373 4 Q15392 1 +Rhizomelia 0.7536508549789264 2.236713261126269 0.0253050867222637 1.0 0.92074266825373 12 Q15392,Q7RTS9,Q14739 3 +Metaphyseal dysplasia 0.7514602871257119 2.2261877773231036 0.0260016063204464 1.0 0.92074266825373 12 Q07864,O95831,Q99575,Q7RTS9,Q9NUQ7,P36776 6 +Barrel shaped chest 0.8848889143705013 2.2195440807399316 0.0264497317761143 1.0 0.92074266825373 5 Q14739,Q7RTS9 2 +Coxa vara 0.7413410332787354 2.2088703740362456 0.0271836583803024 1.0 0.92074266825373 15 Q7RTS9,O95831 2 +Sensory axonal neuropathy 0.7447743904746196 2.1939863359128915 0.028236391886963 1.0 0.92074266825373 12 Q15067,O95831,P34897,Q6DD88,P22626 5 +Increased connective tissue 0.7761747754184779 2.184507219329748 0.0289249973772118 1.0 0.92074266825373 8 P31751,O95831 2 +Keratoconjunctivitis 0.7415309883060573 2.167123409393812 0.0302254453942438 1.0 0.92074266825373 10 Q14739,Q9NZ08,P18074,P06132,P50747 5 +Fragile nails 0.7400140668763675 2.157171122789361 0.0309923335931217 1.0 0.92074266825373 9 P15924,P18074,P19447,Q9Y487,Q13555 5 +Cone shaped epiphysis 0.7380902308962265 2.150770518734648 0.0314943171481105 1.0 0.92074266825373 10 O95831 1 +Abnormal sputum 0.8299092027326306 2.149733126373236 0.0315763305653153 1.0 0.92074266825373 6 Q9NZ08 1 +Broad palm 0.7281984114711169 2.1013269180962846 0.0356122783790722 1.0 0.9718560631577572 9 Q7RTS9,O95831 2 +Impaired tactile sensation 0.7568383864214813 2.09647100453013 0.0360404294494198 1.0 0.9718560631577572 8 P39210,Q6DD88,O43776 3 +Hyperhomocystinemia 0.891311122944195 2.0897553258558066 0.0366397842907006 1.0 0.9718560631577572 4 P41440 1 +Acanthosis nigricans 0.7252316794161614 2.0872504886210983 0.036865497761076 1.0 0.9718560631577572 9 P14923,O14802,P31751,P28070 4 +Toxemia of pregnancy 0.7837789602760752 2.0826253348822488 0.0372853880552943 1.0 0.9718560631577572 7 O43772 1 +Aplasia hypoplasia of the capital femoral epiphysis 0.813676571897431 2.0806061478055047 0.0374699707251864 1.0 0.9718560631577572 6 Q7RTS9 1 +Broad neck 0.7189411572323677 2.068491266892198 0.0385938509743668 1.0 0.9718560631577572 12 P21359,P78318,Q15555,Q93074 4 +Abnormality of the alveolar ridges 0.7503380176632108 2.0666839896492823 0.0387639407685649 1.0 0.9718560631577572 8 Q15392,O43924 2 +Disproportionate short limb short stature 0.6940454021539026 2.0541969242161175 0.0399566359890826 1.0 0.9718560631577572 20 Q15392,Q14739,Q7RTS9,Q32P28,Q7LGA3,Q9UBM7 6 +Limb undergrowth 0.4555569669640686 2.053532415231819 0.0400209692686341 1.0 0.9718560631577572 47 P17612,Q15392,Q14739,P48735,Q7RTS9,O75874,Q9UBM7,P42345 8 +Peripheral axonal degeneration 0.4777956455603112 2.040501568767742 0.0413003949459103 1.0 0.9718560631577572 62 Q15813,Q15067,O95831,P07384,P41440,O15270,P34897,Q6DKK2,Q6DD88,Q15046,Q15526,P22626,P39210,P03886 14 +Cerebral palsy 0.7142281943909483 2.0365434903501383 0.0416958106369216 1.0 0.9718560631577572 10 P98155,Q12824,P48735 3 +Broad foot 0.7139182477514754 2.035050441122648 0.0418457978532167 1.0 0.9718560631577572 10 O95831 1 +Retinal telangiectasia 0.8398686428413836 2.03456231304375 0.0418949326762714 1.0 0.9718560631577572 5 P03886,Q14331 2 +Hemoptysis 0.8394444009128761 2.032802693410382 0.042072460923793 1.0 0.9718560631577572 5 Q9NZ08 1 +Hypoplasia of the odontoid process 0.7957806305670148 2.0038172231607687 0.0450896431850713 1.0 0.9718560631577572 6 O95831 1 +Patchy changes of bone mineral density 0.8697056758971831 2.003254938104941 0.045149931554818 1.0 0.9718560631577572 4 Q13126,Q14739 2 +Cystic hygroma 0.7069039542016262 1.999806093980698 0.0455212063036132 1.0 0.9718560631577572 9 Q14739,P61978 2 +Hyperthyroidism 0.7061144289361048 1.9973803799557308 0.0457838775197549 1.0 0.9718560631577572 10 O14802,Q06787,P53992,Q92890,Q9BUK6,P31749 6 +Premature ventricular contraction 0.7644723260169468 1.9968505051473235 0.0458414252333274 1.0 0.9718560631577572 7 O43772,P15924,P14923 3 +Abnormality of the odontoid process 0.7624146125711384 1.987663653107217 0.0468489013303301 1.0 0.9718560631577572 7 O95831 1 +Enlarged thorax 0.6844318721526492 1.981914167734195 0.0474888479818689 1.0 0.9718560631577572 19 P17612,Q14739,P22681,Q7RTS9,Q99575,Q32P28,O75844 7 +Schwannoma 0.8571255846640814 1.9525687340000368 0.0508707190018871 1.0 0.9718560631577572 4 P21359,Q12824 2 +Secundum atrial septal defect 0.8569311910083368 1.9517836991560464 0.050963890404277 1.0 0.9718560631577572 4 P21359,P34897 2 +Biliary cirrhosis 0.7808675755387635 1.9393731635263365 0.0524559158627684 1.0 0.9718560631577572 6 Q14739,P21266 2 +Fibrous tissue neoplasm 0.6630754125223352 1.9328907315199275 0.0532496598931251 1.0 0.9718560631577572 22 Q13126,Q15392,P21359,P49815 4 +Ventricular tachycardia 0.6907942130270337 1.9255082790698157 0.0541658012158867 1.0 0.9718560631577572 11 P23786,O43772,P15924,P19022,P14923 5 +Myeloid leukemia 0.8502354174385751 1.9247105636195465 0.0542655781995677 1.0 0.9718560631577572 4 P21359 1 +Juvenile myelomonocytic leukemia 0.8502354174385751 1.9247105636195465 0.0542655781995677 1.0 0.9718560631577572 4 P21359 1 +Soft tissue sarcoma 0.5638012607560645 1.920283155345774 0.0548221428927124 1.0 0.9718560631577572 36 Q13126,Q15392,P21359,P49815 4 +Spondyloepimetaphyseal dysplasia 0.7459342902100086 1.9137791566553817 0.0556483798334661 1.0 0.9718560631577572 7 O95831 1 +Absent epiphyses 0.7455164804264878 1.911899025605816 0.0558891466997111 1.0 0.9718560631577572 7 Q7RTS9 1 +Acantholysis 0.8465614474492387 1.9098284604128517 0.0561553035739927 1.0 0.9718560631577572 4 P15924 1 +Slow decrease in visual acuity 0.7139954291169188 1.898407395586392 0.0576424361467813 1.0 0.9718560631577572 8 O75306,Q12824,P03886 3 +Partial agenesis of the corpus callosum 0.6813561511083022 1.8963941409710328 0.057907946053096 1.0 0.9718560631577572 14 Q15392,P57081,Q93074,P18074,P82663 5 +Neoplasm of the nervous system 0.4287718091161822 1.8953433302494969 0.0580469311757805 1.0 0.9718560631577572 49 Q07864,Q12824,P48735,P25054,Q15046,Q01844,P54277,O75874,Q9UPY3,P52701,P21359,Q15555,P49815,P31749,O43924,O60333 16 +Tibial bowing 0.8419325109701861 1.891051128642916 0.0586175194174127 1.0 0.9718560631577572 4 Q7RTS9 1 +Abdominal wall muscle weakness 0.963156679095558 1.886339917081403 0.0592491634640537 1.0 0.9718560631577572 3 P21359 1 +Impaired distal tactile sensation 0.8378298066030443 1.8743836288619649 0.0608775682933051 1.0 0.9718560631577572 4 P39210 1 +Abnormal astrocyte morphology 0.6693801203811587 1.8686945874566911 0.0616653174802186 1.0 0.9718560631577572 17 O95831,P48735,O75874,P49815,P21359 5 +Myositis 0.6790668382686338 1.865426711374491 0.0621216161423356 1.0 0.9718560631577572 9 Q9Y3Z3,P28070,Q9NZ08 3 +Cerebral hamartoma 0.957083231136064 1.8637284553028228 0.0623598472697781 1.0 0.9718560631577572 3 O43924 1 +Neoplasm of the skeletal system 0.472396467524016 1.8630358371678932 0.0624572243630314 1.0 0.9718560631577572 44 P61313,P48735,Q13126,Q92804,P54277,O75874,P08708,Q9Y3Z3,Q9H1A4,P46783,P52701,P49815,P31749 13 +Adenoma sebaceum 0.7958097494497683 1.850249989295711 0.0642775270277442 1.0 0.9718560631577572 5 P49815,P31749 2 +Angiofibromas 0.7958097494497683 1.850249989295711 0.0642775270277442 1.0 0.9718560631577572 5 P49815,P31749 2 +Skin plaque 0.7584546417500027 1.841767451865936 0.0655091729190533 1.0 0.9718560631577572 6 Q06136 1 +Abnormal peripheral action potential amplitude 0.673696685692619 1.839316653944604 0.0658686249204396 1.0 0.9718560631577572 10 P39210 1 +Neonatal hypoglycemia 0.6994209775800488 1.830116422611191 0.067232531726689 1.0 0.9718560631577572 8 O43772,P31751,Q16836 3 +Abnormality of the tonsils 0.7253074707033564 1.8205557227830984 0.0686744185753545 1.0 0.9718560631577572 7 P53992,Q92890,P31751,Q13546 4 +Hypothermia 0.6969103065266115 1.8183072414273775 0.0690171866287654 1.0 0.9718560631577572 8 O43772 1 +Shield chest 0.7528037542152164 1.8170204421307097 0.0692139833126399 1.0 0.9718560631577572 6 Q7RTS9 1 +Disproportionate short stature 0.6328562375088415 1.8156957280729509 0.0694170597361072 1.0 0.9718560631577572 24 Q15392,Q14739,Q7RTS9,Q32P28,Q7LGA3,Q9UBM7 6 +Arthropathy 0.751607642891709 1.811775353117733 0.0700209149083055 1.0 0.9718560631577572 6 O15270,Q6DD88,Q9Y3Z3 3 +Abnormality of neutrophil morphology 0.7866194157661124 1.8114198061692357 0.0700758923564768 1.0 0.9718560631577572 5 Q14739 1 +Chylothorax 0.785570187662572 1.8069786889514183 0.070765602071511 1.0 0.9718560631577572 5 P49815 1 +Tetraplegia 0.6636111202072968 1.7941352512959765 0.0727915837202446 1.0 0.9718560631577572 12 O95831 1 +Perisylvian polymicrogyria 0.8179300977278869 1.793218602331534 0.0729379767305218 1.0 0.9718560631577572 4 P34897 1 +Pituitary adenoma 0.6631984601643716 1.792061859366619 0.0731230575919044 1.0 0.9718560631577572 12 P48735,P54277,O75874,P52701,P49815 5 +Type ii lissencephaly 0.8137894522489616 1.7762654408558136 0.0756891765348375 1.0 0.9718560631577572 4 Q9Y5P6,P07942 2 +Furrowed tongue 0.7433750533338017 1.7756097198943888 0.0757972668226374 1.0 0.9718560631577572 6 P61978 1 +Abnormality of lower limb epiphysis morphology 0.6488401832528613 1.7743695391522405 0.0760020449526659 1.0 0.9718560631577572 18 Q7RTS9,Q7LGA3,O95831 3 +Chondrosarcoma 0.931272607694834 1.7672412875737056 0.0771878278710327 1.0 0.9718560631577572 3 Q92804,P48735 2 +Goiter 0.6857696607566482 1.7657504901238898 0.077437718025219 1.0 0.9718560631577572 8 O75874,P31749,Q9UPY3,P48735 4 +Epidermal acanthosis 0.655002004663221 1.7553778670407063 0.0791946953186957 1.0 0.9718560631577572 13 P50452,Q06136,P15924,Q14574,P14923,Q9H4L7 6 +Hypopigmented macule 0.7716934652920896 1.7480920296464797 0.0804480929121336 1.0 0.9718560631577572 5 P21359 1 +Neoplasm of the skin 0.4358682783056831 1.7465962694231991 0.0807073947855538 1.0 0.9718560631577572 46 P29144,Q12824,P25054,Q06136,P11802,P42224,Q05655,P18074,P54277,Q9UPY3,P19447,Q9H1A4,P21359,P52701,P49815,P31749,Q9H4L7 17 +Neoplasm of the pituitary gland 0.646216672059576 1.7463141556638933 0.0807563774349198 1.0 0.9718560631577572 17 Q12824,P25054,P48735,P54277,O75874,P52701,P49815,P31749 8 +Hypoketotic hypoglycemia 0.7362736929940362 1.744324435084415 0.0811025331644048 1.0 0.9718560631577572 6 O43772,P31751,Q16836 3 +Increased circulating prolactin concentration 0.7060102245648755 1.7326213020376964 0.0831630004987378 1.0 0.9718560631577572 7 Q9BUK6,O14802,P31749,Q12824 4 +Abnormal iliac wing morphology 0.6510655019794055 1.730931326092035 0.0834640136208166 1.0 0.9718560631577572 12 O95831 1 +Neoplasm of the tongue 0.6774968357729488 1.7265622430753855 0.0842463117728442 1.0 0.9718560631577572 8 Q05655,P31749,Q12824,O43924 4 +Sparse lateral eyebrow 0.7035228900320869 1.7212385277655953 0.0852075491716721 1.0 0.9718560631577572 7 Q92643,P61978 2 +Mitochondrial respiratory chain defects 0.800020451980427 1.719738785573116 0.0854799342305465 1.0 0.9718560631577572 4 Q4J6C6,P03886 2 +Hamartoma 0.6320483174834961 1.7169335036596738 0.0859913224626733 1.0 0.9718560631577572 20 P48735,P11802,O75874,P52701,P21359,P49815,P31749,O43924,O60333 9 +Fragile skin 0.6750448673693434 1.714921673733157 0.0863595883615413 1.0 0.9718560631577572 8 P17612,P15924,P06132 3 +Abnormality of renal excretion 0.6746009675881891 1.7128130519466125 0.0867469381646941 1.0 0.9718560631577572 8 O43772,Q9NQ48 2 +Camptodactyly of toe 0.700880392588179 1.7091339534801355 0.0874261394926194 1.0 0.9718560631577572 7 P14923,P15924,Q6W2J9,Q8IWS0 4 +Motor axonal neuropathy 0.64307955848467 1.7081935215037454 0.0876004402248047 1.0 0.9718560631577572 15 O95831 1 +Positive romberg sign 0.7002222626201602 1.7061173721322145 0.087986228737475 1.0 0.9718560631577572 7 P18887,P41440 2 +Abnormality of pancreas physiology 0.4865091567769236 1.704039806266595 0.0883736508091428 1.0 0.9718560631577572 41 Q14739,P05165,Q9NZ08,P21266,Q4G0N4,P03886 6 +Pleural effusion 0.6433967826619801 1.7020626598336297 0.088743622723046 1.0 0.9718560631577572 14 P49815,Q14739,Q9NZ08 3 +Neuropathic arthropathy 0.7956519993622567 1.701757730238535 0.0888007933592172 1.0 0.9718560631577572 4 Q6DD88 1 +Metaphyseal widening 0.6215923642761287 1.6998698646705386 0.0891554064402151 1.0 0.9718560631577572 22 Q7RTS9,O95831 2 +Skin rash 0.631896681625688 1.6985677638693168 0.0894006546334456 1.0 0.9718560631577572 19 Q14739,P28070,Q06136,P22681,P40763,P18074,P19447,P14174,P50747,Q9H4L7 10 +Abnormal corneal epithelium morphology 0.6309179721569788 1.6932285349637528 0.0904119750822141 1.0 0.9718560631577572 19 Q14739,Q96EK5,Q9NZ08,P18074,P06132,P39210,P50747,O75844 8 +Widened cerebral subarachnoid space 0.7928753039442686 1.690317212902131 0.0909672837682498 1.0 0.9718560631577572 4 O43776,P03886 2 +Focal cortical dysplasia 0.9103655669970716 1.6886563085967097 0.0912853130941846 1.0 0.9718560631577572 3 P49815 1 +Large beaked nose 0.7233089422477852 1.6870026256256028 0.0916028470900336 1.0 0.9718560631577572 6 P18074,O14802 2 +Astrocytoma 0.6426531818289778 1.6856835146174036 0.0918567737832587 1.0 0.9718560631577572 10 P48735,O75874,P52701,P49815,P21359 5 +Ependymoma 0.7556902586397638 1.679850109777889 0.0929864827214435 1.0 0.9718560631577572 5 P49815,O75874 2 +Organic aciduria 0.5124977134697051 1.679403580979262 0.0930734158677037 1.0 0.9718560631577572 38 P05165,P48735,O43772,Q96RQ3,P13804,O14678,Q4G0N4,P50747 8 +Tinnitus 0.6373834374700775 1.6784730050983814 0.0932547960781602 1.0 0.9718560631577572 15 O95831,Q12824,P21359,P31749,O60333 5 +Aplasia hypoplasia involving the vertebral column 0.6356949087570957 1.6696499540326952 0.094988640775609 1.0 0.9718560631577572 15 Q7RTS9,Q14739,O14802,O95831 4 +Right ventricular cardiomyopathy 0.752261233780843 1.665184132185907 0.0958760257170607 1.0 0.9718560631577572 5 P15924 1 +Mild short stature 0.7862742368376179 1.663085230243252 0.0962953759529876 1.0 0.9718560631577572 4 Q14739 1 +Capillary hemangioma 0.6908228383240242 1.6629549518368434 0.0963214532342431 1.0 0.9718560631577572 7 Q7LGA3,Q9UBM7 2 +Osteomyelitis 0.6265927080919701 1.6545977947568264 0.0980061111455832 1.0 0.9760392624023416 18 Q13126,P39210 2 +Calcinosis 0.7477513722910363 1.6458729857774037 0.0997899117621086 1.0 0.9823511096865288 5 Q14739,P57678 2 +Pain insensitivity 0.7476186253608949 1.6453041865094846 0.0999070969357509 1.0 0.9823511096865288 5 P39210 1 +Abnormality of the helix 0.4683920804815523 1.639341978415355 0.1011420580778263 1.0 0.9823511096865288 42 P23786,O43776,P15924,P22681,P62266,Q93074,P53992,P19022,Q6W2J9,P21359,P14923,P52788,O75844,Q7LGA3,P36776 15 +Corneal ulceration 0.7461980652627053 1.6392159750097302 0.1011682879731217 1.0 0.9823511096865288 5 O75844,P06132 2 +Bilateral cryptorchidism 0.6330712118857064 1.637847264807535 0.1014535590745642 1.0 0.9823511096865288 10 P27635,Q07864,P37268,P78318,O43924 5 +Brain neoplasm 0.7797697261130994 1.6362059870121444 0.1017964838501355 1.0 0.9823511096865288 4 P21359,Q07864 2 +Abnormal urine ph 0.4781678737312582 1.636034075989855 0.1018324558660825 1.0 0.9823511096865288 41 P05165,P48735,O43772,Q96RQ3,P13804,O14678,Q4G0N4,P50747,P03886 9 +Widely patent fontanelles and sutures 0.7452793640289803 1.6352773239942242 0.1019909249448871 1.0 0.9823511096865288 5 O75844,Q93074 2 +Corneal erosion 0.7452151633590834 1.6350020453425602 0.102048618854879 1.0 0.9823511096865288 5 Q96EK5,P39210 2 +Raynaud phenomenon 0.7109653342115563 1.6321929108677846 0.102638853720232 1.0 0.9853853056989792 6 Q14739,O75844 2 +Retrocollis 0.8948748209302013 1.6302136587771976 0.1030563481325539 1.0 0.9858772224879796 3 P35637 1 +Micromelia 0.6150058399525957 1.6226484797514376 0.1046645706958733 1.0 0.9969247382160932 20 Q15392,Q14739,P48735,O75874,Q9UBM7 5 +Tetany 0.7084279807674049 1.6208993191400878 0.1050392329130676 1.0 0.9969247382160932 6 P53992,Q15813,Q92890 3 +Increased sulfur amino acid level in urine 0.7415345812298413 1.6192123187297924 0.1054015883998018 1.0 0.9969247382160932 5 O14678 1 +Corneal neovascularization 0.7070544009888539 1.6147819069717857 0.1063579326502044 1.0 0.997949089893478 6 P53992,P18074,Q92890 3 +Prominent sternum 0.8906831700288693 1.6143714203017334 0.1064468869909851 1.0 0.997949089893478 3 O95831 1 +Abnormal corpus striatum morphology 0.6209993308429622 1.6012014826647152 0.1093323005725308 1.0 0.997949089893478 16 O14802,O95831,P42858,O75306,Q9Y3Z3 5 +Lipoma 0.6774045886184021 1.6010905610835264 0.1093568625061927 1.0 0.997949089893478 7 P27635,Q9BUK6,P31749 3 +Conical tooth 0.7038978501811144 1.6007141145703452 0.1094402535139451 1.0 0.997949089893478 6 P17612,Q9Y487,P61586 3 +Impaired pain sensation 0.6132723513091746 1.5966324684514217 0.1103476570166273 1.0 0.997949089893478 19 P61978,O95831,Q6DD88,Q13045,P39210 5 +Hemangiomatosis 0.8858927984215671 1.5962528209304585 0.1104323588581901 1.0 0.997949089893478 3 O75874,P48735 2 +Visceral angiomatosis 0.8858927984215671 1.5962528209304585 0.1104323588581901 1.0 0.997949089893478 3 O75874,P48735 2 +Lymphangioma 0.8858927984215671 1.5962528209304585 0.1104323588581901 1.0 0.997949089893478 3 O75874,P48735 2 +Palpebral edema 0.7349012280745442 1.5907156079850475 0.1116735927247778 1.0 0.997949089893478 5 Q14331 1 +Stuttering 0.768476477080689 1.5894367520293309 0.1119618227312679 1.0 0.997949089893478 4 P03886 1 +Gaze evoked nystagmus 0.6227479776988631 1.5881769069956186 0.1122463414881487 1.0 0.997949089893478 9 P41440 1 +Metatarsus adductus 0.6223613125771672 1.5881593012142317 0.1122503215486476 1.0 0.997949089893478 13 Q15392 1 +Severe intrauterine growth retardation 0.8836315513224127 1.5876953260808573 0.1123552504554972 1.0 0.997949089893478 3 O14802 1 +Hamartoma of the eye 0.62273475347832 1.5856553214765887 0.1128175194509031 1.0 0.997949089893478 11 P49815,P21359,P31749,O60333 4 +Neoplasm of the adrenal cortex 0.7001494430475095 1.583991396677919 0.1131956769258504 1.0 0.997949089893478 6 O75874,P48735 2 +Neutropenia in presence of anti neutropil antibodies 0.6472325334392139 1.582109162091001 0.1136246523951585 1.0 0.997949089893478 8 P29144,P40763,P42224,Q05655,Q96J02,O95394 6 +Abnormal ossification involving the femoral head and neck 0.7321984458919182 1.5790904323420654 0.1143153159199985 1.0 1.0 5 Q7RTS9 1 +Retinal hamartoma 0.6205637502937997 1.5751347439948495 0.1152253458317402 1.0 1.0 10 P49815,P21359,P31749 3 +Absent toenail 0.6453899041146327 1.5732625294653808 0.1156580418472863 1.0 1.0 8 P15924,Q14739,P14923 3 +Prenatal maternal abnormality 0.6194645852823237 1.5732189026468335 0.1156681398488339 1.0 1.0 13 O43772 1 +Somatic mutation 0.4059431985421433 1.5729568800056304 0.1157288030219947 1.0 1.0 47 Q92733,Q12824,P30154,P37287,Q92804,P22681,Q01844,P61586,Q13951,O75874,Q9UPY3,P52701,P21359,P49815,P31749,P42345,O60333 17 +Ragged red muscle fibers 0.6168725882009576 1.5709214512194714 0.1162008952253033 1.0 1.0 15 O95831,Q86U42,Q9H2D1,Q9Y5P6,Q9H553,P03886 6 +Abnormal myeloid cell morphology 0.7629408041480834 1.5664679175015643 0.1172391136833819 1.0 1.0 4 P41440 1 +Impaired visuospatial constructive cognition 0.6439365892097193 1.5662811340678944 0.1172828156851877 1.0 1.0 8 P21359,P03886 2 +Abnormality of the calf 0.4181854451607888 1.557979394796256 0.1192381327177982 1.0 1.0 58 O95831,Q13126,Q7RTS9,Q32P28,P21359,Q7LGA3 6 +Overgrowth 0.6679335405546029 1.5572605105494963 0.1194086470021416 1.0 1.0 7 P37287,P21359,P61978 3 +Migraine 0.5961485670718953 1.555050203756269 0.1199341131631164 1.0 1.0 22 Q9NQZ5,Q12824,Q9NZ08,P21359,P03886 5 +Aphthous ulcer 0.6657148931079351 1.5469745843287952 0.1218693743915015 1.0 1.0 7 Q9NZ08,P78527 2 +Episodic vomiting 0.6137115571926565 1.5430921169908305 0.1228084271219489 1.0 1.0 9 P03886 1 +Aplasia hypoplasia involving the femoral head and neck 0.614156089738586 1.542894509575322 0.1228563731891716 1.0 1.0 10 O95831 1 +Relative macrocephaly 0.5471710097621812 1.5367340088329082 0.1243584593301643 1.0 1.0 31 O14802,Q15392,Q07864,Q99575,P21359,O75844,Q7LGA3 7 +Buphthalmos 0.755558725565139 1.535796737450757 0.124588240154714 1.0 1.0 4 A1X283,P31749 2 +Bone cyst 0.8698102053639212 1.535328756502002 0.1247030939267901 1.0 1.0 3 P21359 1 +Abnormal circulating amino acid concentration 0.3919925049813921 1.525428630148452 0.1271522222520398 1.0 1.0 49 P11498,P05165,P41440,P78330,Q15046,Q96RQ3,O14678,Q4G0N4,P03886 9 +Hemianopia 0.6347847720673774 1.5222413846772649 0.1279486090350592 1.0 1.0 8 P03886,Q12824 2 +Macrovesicular hepatic steatosis 0.6861787321986711 1.5215083506836726 0.1281323173393964 1.0 1.0 6 P39210,P23786 2 +Abnormal urinary color 0.6855750412379443 1.5188031426983466 0.1288120546241109 1.0 1.0 6 P49815,P23786,P06132 3 +Abnormal size of pituitary gland 0.6853211963806239 1.5176655114597375 0.1290987426195597 1.0 1.0 6 P31749,Q12824,Q93074 3 +Abnormal thalamic size 0.7511697399360678 1.5175404926935752 0.1291302780934544 1.0 1.0 4 Q9Y5P6,Q9UPT5 2 +Glioblastoma multiforme 0.6081802182596401 1.5154235963011584 0.1296651655288214 1.0 1.0 9 P54277,O75874,P52701 3 +Speech articulation difficulties 0.7498432870870461 1.5120201520467305 0.1305287360198188 1.0 1.0 4 P21359 1 +Abnormal dermoepidermal junction morphology 0.8634938664979119 1.5113663082120017 0.1306951484119181 1.0 1.0 3 P15924 1 +Mesomelia 0.6836211288606816 1.5100446203337796 0.1310320389737116 1.0 1.0 6 Q14739 1 +Ridged nail 0.7145564926454189 1.5030246538931469 0.1328326865871298 1.0 1.0 5 P18074 1 +Gastrointestinal stroma tumor 0.7468236098861354 1.4994482853553863 0.1337573751909124 1.0 1.0 4 P21359 1 +Abnormality of the calcaneus 0.6297621764872701 1.498018288194099 0.1341284990130182 1.0 1.0 8 Q7RTS9 1 +Retinal pigment epithelial atrophy 0.7459127442675522 1.4956547957710766 0.1347436358632674 1.0 1.0 4 Q8TC12,P50213 2 +Neoplasm of the oral cavity 0.6033665508657771 1.489928091752652 0.1362431442751148 1.0 1.0 13 Q12824,P25054,Q05655,P52701,P31749,O43924 6 +Cubitus valgus 0.6020397466980336 1.4830446913400464 0.1380625372500126 1.0 1.0 13 P21359,Q99575,P22681 3 +Abnormal central sensory function 0.7096361090937093 1.481757754669979 0.138404763489043 1.0 1.0 5 P31749,Q12824,O75787 3 +Pulmonary embolism 0.70952931240772 1.48129592984504 0.1385277326276419 1.0 1.0 5 P31749,Q9NZ08 2 +Megalencephaly 0.8553107530417554 1.480297769956341 0.1387937981263272 1.0 1.0 3 P49815,P42345 2 +Abnormal circulating branched chain amino acid concentration 0.7088971619909578 1.4785621058361993 0.1392573868201174 1.0 1.0 5 Q96RQ3 1 +Keratitis 0.600732679161514 1.4762611099707006 0.1398738099777472 1.0 1.0 13 Q14739,Q9NZ08,P18074,P06132,P50747 5 +Visual acuity test abnormality 0.7066964090938687 1.4690421036326695 0.1418213696226768 1.0 1.0 5 P31749,Q12824,P25054 3 +Abnormality of the 5th toe 0.6485195644394425 1.4670363021843684 0.1423661802574041 1.0 1.0 7 Q14739,Q9UBM7,O43924 3 +Postaxial foot polydactyly 0.6485195644394425 1.4670363021843684 0.1423661802574041 1.0 1.0 7 Q14739,Q9UBM7,O43924 3 +Abnormal vitamin b12 level 0.6484599628816341 1.4667585946176542 0.1424417369470496 1.0 1.0 7 P41440 1 +Ambiguous genitalia 0.5892998704761683 1.464513304132313 0.1430537506694031 1.0 1.0 19 Q15392 1 +Panhypogammaglobulinemia 0.7052786798417523 1.462907260505666 0.1434927570440387 1.0 1.0 5 P18074,P19447 2 +Meningioma 0.5971665159832975 1.4601812798108194 0.144240258836106 1.0 1.0 9 P21359,Q12824 2 +Peters anomaly 0.8497204866820036 1.4590601823499338 0.144548544159119 1.0 1.0 3 P19022,Q12948 2 +Bifid tongue 0.7366109638166067 1.456884331689692 0.1451483117871035 1.0 1.0 4 Q9UBM7 1 +Split nail 0.7360933050264782 1.4547251297265402 0.1457453726933666 1.0 1.0 4 P18074 1 +Abnormality of the parathyroid gland 0.5817180251665749 1.4535674299653027 0.1460662723117713 1.0 1.0 21 Q15813,P48735,P49815,O75874,P21359,P03886 6 +Increased adipose tissue 0.7356309159170049 1.4527963326941042 0.1462803104922962 1.0 1.0 4 P31751 1 +Sensory neuropathy 0.5618547628223469 1.45204077567231 0.1464902677761728 1.0 1.0 26 Q15067,O95831,P07384,P26358,P34897,Q6DD88,P22626,P03886 8 +Absent eyebrow 0.7027335731284534 1.4518901182904618 0.1465321606226193 1.0 1.0 5 P15924,O75844,P14923 3 +Alopecia totalis 0.7027335731284534 1.4518901182904618 0.1465321606226193 1.0 1.0 5 P15924,O75844,P14923 3 +Cutaneous melanoma 0.7340957412218309 1.446391684681508 0.1480673728189794 1.0 1.0 4 P11802,P19447 2 +Autoimmune thrombocytopenia 0.5943117000144319 1.4458315276802165 0.1482244608533607 1.0 1.0 9 P40763,Q05655,P29144,Q92888 4 +Supernumerary tooth 0.6177842172543816 1.4401096494965968 0.1498363794897521 1.0 1.0 8 Q9UBM7,Q6W2J9,P62266 3 +Insulin resistant diabetes mellitus 0.642407139725883 1.438535445050155 0.1502821879376479 1.0 1.0 7 P40763,O75844,P31751,Q96MF7 4 +Thyroiditis 0.6420050182160885 1.4366590259620198 0.1508149028445604 1.0 1.0 7 P49327,P42224,Q05655,Q96J02,P31749 5 +Polyneuropathy 0.5914323346461646 1.4365144892843795 0.1508559963952653 1.0 1.0 15 P21359,O95831 2 +Progressive external ophthalmoplegia 0.6411426476661719 1.4326343781612705 0.1519623518081672 1.0 1.0 7 Q07021,P51530,P00403,P03886,O60313 5 +Abnormal aortic arch morphology 0.5921976339209086 1.4302207861928002 0.1526536614295652 1.0 1.0 11 P30153,P53992,Q92890,Q6W2J9,P21964 5 +Limb muscle weakness 0.4462770256119834 1.4278686063468284 0.1533296811763649 1.0 1.0 75 Q15813,Q14739,Q8N0X7,Q15067,Q12824,P07384,Q13126,O15270,Q7RTS9,Q6DD88,Q15046,Q99720,Q9Y5P6,Q15120,Q16637,P39210,P21359,P31749 18 +Thoracic kyphosis 0.5867499168996244 1.4184630003693373 0.1560556335642295 1.0 1.0 16 O43776,O95831,Q99575,Q7RTS9,P18074 5 +Antinuclear antibody positivity 0.6939782823297088 1.4139554166937314 0.1573749931771211 1.0 1.0 5 Q9Y5L0,Q13546,Q05655,P53621 4 +Biparietal narrowing 0.587799693596001 1.4130552758810055 0.1576394720067082 1.0 1.0 9 O43924 1 +Abnormality of the pituitary gland 0.4157314618018822 1.4115527591355663 0.1580816905639994 1.0 1.0 63 O14802,P48735,Q8NI27,P82650,Q15813,Q07864,Q06787,P57081,Q93074,Q9BUK6,Q7Z392,Q12824,P25054,O14654,P54277,O75874,Q96MF7,Q15233,P31749,Q96ST3,Q99496,P52701,P49815,Q4J6C6 24 +Abnormal epidermal morphology 0.5742631500464218 1.4112801610244134 0.1581620218395361 1.0 1.0 21 P50452,Q06136,P15924,Q14574,Q9Y3Z3,O75844,P14923,Q9H4L7 8 +Supernumerary nipple 0.588068849986721 1.4109430005638577 0.1582614215962823 1.0 1.0 10 P19022,P61978,Q7LGA3,Q9Y4A5 4 +Recurrent paroxysmal headache 0.5867393568304391 1.4022914874038916 0.1608282213760672 1.0 1.0 11 P21359 1 +Abnormal circulating bilirubin concentration 0.5532307365481013 1.3996137432749876 0.1616290162252138 1.0 1.0 26 P23786,P00390,Q14739,P08237,P41440,P37287,Q9Y5L0,P43034,P11171,Q9NSD9,Q02241,P40855 12 +Thoracolumbar scoliosis 0.6338753275902298 1.398688611010849 0.161906380964623 1.0 1.0 7 Q99575,P78318,P36776 3 +Synostosis involving digits 0.7207477556211402 1.390655510793656 0.1643299145698358 1.0 1.0 4 O60828,Q9H1A4 2 +Oromandibular dystonia 0.8313054916145926 1.3890490421843658 0.1648178376207474 1.0 1.0 3 P35637,Q99720 2 +Increased susceptibility to fractures 0.3857243074704005 1.3849437221719072 0.1660696764209779 1.0 1.0 52 P17612,Q14739,P48735,Q13126,Q6DD88,Q32P28,O75874,P39210 8 +Abnormal circulating long chain fatty acid concentration 0.8296612956264348 1.3827956874412486 0.1667275217014903 1.0 1.0 3 P23786,P40855 2 +Decreased specific antibody response to vaccination 0.7177915977547944 1.3783017186929851 0.1681101527882309 1.0 1.0 4 Q9BV10,P17812 2 +Multiple suture craniosynostosis 0.6853341913053046 1.3764561161315974 0.1686804647590409 1.0 1.0 5 P53992,Q92890 2 +Tricuspid atresia 0.6853341913053046 1.3764561161315974 0.1686804647590409 1.0 1.0 5 P53992,Q92890 2 +Aplasia hypoplasia of the skin 0.3895268168086733 1.3726788443310909 0.1698522088330363 1.0 1.0 54 P17612,O14802,Q15392,Q9NWM8,Q13126,P15924,Q96PU5,P18074,O75844,Q9H4L7 10 +Aqueductal stenosis 0.6515294158296137 1.3656590878042605 0.1720459911707439 1.0 1.0 6 P21359 1 +Multiple prenatal fractures 0.6510238953090265 1.3633780259136672 0.1727634027770264 1.0 1.0 6 Q14739 1 +Pigmentary retinopathy 0.3844408194728101 1.3620437032555373 0.1731840932440702 1.0 1.0 47 O14802,Q15067,Q16836,Q7KZN9,P50213,P28331,O75306,Q15526,Q9Y5P6,Q9BSH4,P19447,Q9BUK6,Q15555,P03886,Q9NQ48 15 +Bowing of the legs 0.3755435464833139 1.358778118403216 0.1742169091660033 1.0 1.0 49 Q13126,Q7RTS9,Q32P28,P21359,Q7LGA3 5 +Low set nipples 0.8232786492812412 1.3585195648339938 0.1742988787470674 1.0 1.0 3 P18074 1 +Bronchospasm 0.8232786492812412 1.3585195648339938 0.1742988787470674 1.0 1.0 3 P18074 1 +Increased mean corpuscular hemoglobin concentration 0.8232786492812412 1.3585195648339938 0.1742988787470674 1.0 1.0 3 P18074 1 +Tiger tail banding 0.8232786492812412 1.3585195648339938 0.1742988787470674 1.0 1.0 3 P18074 1 +Concave nail 0.8232786492812412 1.3585195648339938 0.1742988787470674 1.0 1.0 3 P18074 1 +Limb pain 0.6007568563234672 1.3574924778771462 0.1746247819404729 1.0 1.0 8 Q6DD88 1 +Abnormal femoral head morphology 0.561586599329532 1.3566846237926806 0.174881440196398 1.0 1.0 22 Q7RTS9,O95831,Q99575 3 +Abnormal hypothalamus morphology 0.8227406689368973 1.3564733667885756 0.1749486037527949 1.0 1.0 3 O43924 1 +Olivopontocerebellar hypoplasia 0.6799359863215606 1.3530189088512603 0.1760495896696237 1.0 1.0 5 Q9Y5P6,Q9H9S5 2 +Glioma 0.5751373051852077 1.3499710502432878 0.1770252691728804 1.0 1.0 15 P49815,P54277,P21359,P48735 4 +Atlantoaxial abnormality 0.7105029573505033 1.3478312650202997 0.177712659558042 1.0 1.0 4 O14802,Q7RTS9 2 +Abnormal metatarsal morphology 0.5486425048477583 1.3455409033977055 0.1784506213998193 1.0 1.0 25 Q15392,A1X283,Q7RTS9,P31749,Q9UBM7,Q9NQ48 6 +Abnormality of pain sensation 0.5524671013029342 1.3446036898010338 0.1787532511614982 1.0 1.0 24 P61978,O95831,Q6DD88,Q13045,P39210 5 +Optic disc hypoplasia 0.7075450767418537 1.33546221004143 0.1817251156688661 1.0 1.0 4 O14802,P25054 2 +Abnormal circulating acetylcarnitine concentration 0.6439982581877765 1.3316605827674692 0.1829717474285994 1.0 1.0 6 O43772,Q16836 2 +Femoral bowing 0.5954115845097094 1.3314977503384915 0.1830252847356397 1.0 1.0 8 Q7RTS9 1 +Increased sensitivity to ionizing radiation 0.6742698959492722 1.3284062492276485 0.1840439361013728 1.0 1.0 5 P31749,Q12824 2 +Decreased circulating follicle stimulating hormone concentration 0.6742698959492722 1.3284062492276485 0.1840439361013728 1.0 1.0 5 P31749,Q12824 2 +Decreased circulating gonadotropin concentration 0.6742698959492722 1.3284062492276485 0.1840439361013728 1.0 1.0 5 P31749,Q12824 2 +Red eye 0.5608544227235898 1.319889754666141 0.1868718287250246 1.0 1.0 20 Q14739,P28070,P34897,Q9NZ08,P18074,P06132,P50747 7 +Centrocecal scotoma 0.811506825006997 1.3137502630196136 0.1889302602091926 1.0 1.0 3 P03886 1 +Benign neoplasm of the central nervous system 0.5432872835139111 1.3134010620451375 0.1890478398331754 1.0 1.0 25 Q12824,P54277,P21359,P49815,P31749,O43924,O60333 7 +Ventricular arrhythmia 0.5072228543476 1.3131280434315995 0.1891398056297155 1.0 1.0 32 P23786,O43772,P15924,O75306,P19022,P49815,Q8N335,P03886,P14923 9 +Asymmetry of the ears 0.7021879261735534 1.313056761120711 0.1891638223681391 1.0 1.0 4 P52788,Q6W2J9 2 +Abnormal exteroceptive sensation 0.3682018001649448 1.310019355167529 0.190189287945699 1.0 1.0 48 P61978,O95831,Q6DD88,Q9NZ08,P06132,P39210 6 +Abnormal circulating sulfur amino acid concentration 0.5666744942228461 1.3063689289079274 0.1914271268374991 1.0 1.0 9 P41440 1 +Fetal onset 0.6370776684743625 1.3003931430370927 0.193466258864416 1.0 1.0 6 P27635,Q99496,Q9NSD9 3 +Abnormal intraocular pressure 0.6676969399724088 1.299842514572867 0.1936549508084994 1.0 1.0 5 Q15043,Q99496,O75533 3 +Muscle hypertrophy of the lower extremities 0.5880445155117503 1.295633888800537 0.1951016479238911 1.0 1.0 8 Q9Y5P6,Q9H9S5,Q14331 3 +Scleroderma 0.6664350661306031 1.2943578148190926 0.1955418548956171 1.0 1.0 5 Q14739 1 +Abnormal circulating dicarboxylic acid concentration 0.4451129019666424 1.293145520203851 0.1959607339473876 1.0 1.0 40 P23786,P00390,Q14739,P08237,P48735,P41440,P37287,P43034,Q16134,P11171,P37268,Q9Y5L0,P13804,O14678,Q02241,P40855 16 +Aplasia hypoplasia of the earlobes 0.5625884110476574 1.2856820579677926 0.198554045468781 1.0 1.0 9 P53992,Q92890,O14802,P52788 4 +Pheochromocytoma 0.5633781719375583 1.2852468978763425 0.1987060200351322 1.0 1.0 10 P49815,P21359 2 +Aniridia 0.5637320009307141 1.282967096806937 0.1995036038015945 1.0 1.0 12 Q12948 1 +Anonychia 0.5635552963023747 1.2820508493195002 0.1998248091225791 1.0 1.0 12 P15924,Q14739,P14923 3 +Intestinal pseudo obstruction 0.5618225597473627 1.281803272269177 0.199911666028272 1.0 1.0 9 P03886 1 +Abnormal circulating ige level 0.6937500000000068 1.2777633806050142 0.2013328698519347 1.0 1.0 4 P40763,Q05655,O95394 3 +Increased circulating iga level 0.6937500000000065 1.2777633806050128 0.2013328698519352 1.0 1.0 4 Q9Y5L0,Q05655,O95394 3 +Emg slow motor conduction 0.800554433935581 1.2721183561422578 0.2033310701011326 1.0 1.0 3 Q6DD88 1 +Penetrating foot ulcers 0.800554433935581 1.2721183561422578 0.2033310701011326 1.0 1.0 3 Q6DD88 1 +Trophic changes related to pain 0.800554433935581 1.2721183561422578 0.2033310701011326 1.0 1.0 3 Q6DD88 1 +Germinoma 0.6922492958312402 1.2714866574184052 0.2035555711607832 1.0 1.0 4 P31749,Q9UPY3 2 +Pain in head and neck region 0.6065669183791779 1.270759241863626 0.2038143127402127 1.0 1.0 7 P31749,Q15043,Q99496,Q12824 4 +Neoplasm of the adrenal gland 0.5608660201519362 1.270321638707728 0.2039700833710251 1.0 1.0 14 P21359,O60333,O75874,P48735 4 +Increased proteinogenic amino acid level in urine 0.559975790055381 1.2648860412080554 0.2059121818854692 1.0 1.0 11 P05165,O14678 2 +Hypothalamic hypothyroidism 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Brain stem compression 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Transient global amnesia 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Progressive pulmonary function impairment 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Neuralgia 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Intracranial meningioma 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Secondary growth hormone deficiency 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Ear pain 0.6892063394936081 1.2587602543066434 0.2081169403589318 1.0 1.0 4 P31749,Q12824 2 +Abnormality of the nasolabial region 0.6570904365735657 1.253736634420362 0.2099377476059132 1.0 1.0 5 P21359 1 +Prominent nasolabial fold 0.6570904365735657 1.253736634420362 0.2099377476059132 1.0 1.0 5 P21359 1 +Calvarial hyperostosis 0.6266481372090952 1.253241240824526 0.2101179253776977 1.0 1.0 6 P22626,P31749 2 +Abnormal femoral neck head morphology 0.3937548423859091 1.251645538698858 0.2106990531252228 1.0 1.0 45 Q14739,O95831,Q7RTS9,Q99575,Q7LGA3 5 +Decreased specific antibody response to protein vaccine 0.7951331798750366 1.251524638767502 0.2107431301744093 1.0 1.0 3 Q9BV10,P17812 2 +Hypoplastic vertebral bodies 0.6259079223734223 1.2498938398732833 0.2113383300069133 1.0 1.0 6 Q14739,O14802 2 +Hypoplastic aortic arch 0.6864022695332409 1.2470342905444365 0.2123849245612277 1.0 1.0 4 Q6W2J9,P30153 2 +Impaired antigen specific response 0.5763474131300899 1.2386241752533589 0.2154847108934425 1.0 1.0 8 P17812,Q05655,Q9BV10,Q13546,O95394 5 +Postaxial polydactyly 0.5536460285634146 1.23550064460054 0.2166442367085093 1.0 1.0 15 P17612,Q14739,P61978,Q9UBM7,O43924 5 +Woolly hair 0.5989979295121539 1.235235096182131 0.216743021034885 1.0 1.0 7 P15924,P14923 2 +Natal tooth 0.5745374896110356 1.2297977380289986 0.2187728554826229 1.0 1.0 8 P15924,O75844,P14923 3 +Pseudoarthrosis 0.6821903404267863 1.2294244133818146 0.2189127215580191 1.0 1.0 4 P21359 1 +Abnormal mean corpuscular hemoglobin concentration 0.6820488332538293 1.2288328647785445 0.2191344767198582 1.0 1.0 4 P18074 1 +Decreased plasma carnitine 0.5517640427908137 1.2259483281096195 0.2202181205422186 1.0 1.0 10 O43772,Q16836,Q4G0N4 3 +Intestinal malrotation 0.5156782862323489 1.2252854549510217 0.2204676866725994 1.0 1.0 28 Q15392,Q14739,Q93074,P53992,Q6W2J9,Q9UBM7 6 +Autoamputation 0.6195494995262806 1.221137859080348 0.2220338274383033 1.0 1.0 6 P39210 1 +Pilomatrixoma 0.6782539122639292 1.2129713018758728 0.2251407928063553 1.0 1.0 4 Q9UPY3,P25054 2 +Hyperlordosis 0.3635788965139271 1.212479462937155 0.2253288993508058 1.0 1.0 50 Q14331,Q7RTS9,Q9H9S5,Q99575,Q93074,Q13642,Q9Y5P6,Q9H553,P22626,P55795,Q6W2J9,P21359,Q96J02 13 +Abnormal nipple morphology 0.3832498444081397 1.2121513715808578 0.2254544421097044 1.0 1.0 58 P23786,Q15067,P61978,Q96EK5,P22681,Q9BV10,P18074,P19022,P19447,O14678,P21359,Q15555,Q7LGA3,Q9UBM7,Q9Y4A5 15 +Aplasia hypoplasia of the optic nerve 0.5456482716523176 1.212138089739068 0.225459525401519 1.0 1.0 18 O14802,P61978,P30153,P37268,Q9H9S5,Q93074,Q9Y5P6 7 +Occipital encephalocele 0.6171210950889847 1.2101552902378343 0.2262193104680603 1.0 1.0 6 Q9Y5P6,P07942 2 +Panniculitis 0.5690694852757232 1.2031269551831472 0.2289271958537249 1.0 1.0 8 P28070,Q9Y3Z3 2 +Increased level of hippuric acid in urine 0.6758026685280132 1.202728801398109 0.2290812846808041 1.0 1.0 4 P05165 1 +Abnormal circulating follicle stimulating hormone concentration 0.5462192944668123 1.2027013252717718 0.2290919208925332 1.0 1.0 9 Q96MF7,P31749,Q12824 3 +Aplasia hypoplasia of metatarsal bones 0.5919249829022819 1.2020297691704054 0.2293519945164834 1.0 1.0 7 Q7RTS9 1 +Ventricular preexcitation 0.6448908572884918 1.2007123193853415 0.2298628136862102 1.0 1.0 5 P49815,P03886 2 +Single fiber emg abnormality 0.6743421052631696 1.1966270980577944 0.2314519335579601 1.0 1.0 4 Q9Y5P6,Q9H553,O75340 3 +Muscle fiber tubular inclusions 0.6743421052631696 1.1966270980577944 0.2314519335579601 1.0 1.0 4 Q9Y5P6,Q9H553,O75340 3 +Optic nerve hypoplasia 0.5463021093618866 1.1934083699108524 0.2327094785935992 1.0 1.0 14 P61978,P37268,Q9H9S5,Q93074,Q9Y5P6 5 +Ectopia pupillae 0.6428763135090081 1.191959561080962 0.233277101990224 1.0 1.0 5 Q12948,P61586 2 +Hemiplegia hemiparesis 0.4403915347967143 1.1903560597975626 0.2339064755952646 1.0 1.0 39 Q12824,Q9H9S5,Q9NZ08,P57081,Q9Y5P6,P54277,Q9Y3Z3,P52701,P49815,P03886,P31749,P42345 12 +Symptomatic seizures 0.5660443585344243 1.1883696025743231 0.2346878268390555 1.0 1.0 8 P31751,Q16836 2 +Arterial thrombosis 0.5657431560616643 1.1869002255281047 0.2352669783681513 1.0 1.0 8 P31749,Q9NZ08 2 +Brachydactyly 0.4114656165671206 1.1848468530069771 0.2360780039083163 1.0 1.0 71 Q8N0X7,O95831,Q7RTS9,P22681,O14497,Q08209,P36776,Q9NQ48,Q14739,Q06136,A1X283,Q93074,Q8TC12,O43924,P31749,Q9UBM7,Q96ST3,Q92643,Q99575,Q13045,Q13555 21 +Epidermoid cyst 0.6712577129446371 1.1837450479687095 0.2365140008707089 1.0 1.0 4 P49815 1 +Aplasia hypoplasia involving the pelvis 0.5443019085389604 1.1828433753513568 0.2368712264894679 1.0 1.0 14 O95831 1 +Abnormal renal pelvis morphology 0.3554785615164132 1.1810822830268113 0.2375700373838956 1.0 1.0 48 P23786,O14802,Q8N0X7,Q07864,P61978,P25054,O75381,Q6W2J9,P57678,P21359,Q08209,Q9UBM7,P40855,Q9Y4A5 14 +Skin appendage neoplasm 0.6394021279256503 1.1768684612218108 0.2392480120326294 1.0 1.0 5 Q9UPY3,P25054 2 +Oculomotor nerve palsy 0.6393486991889842 1.17663641721915 0.2393406558775574 1.0 1.0 5 P31749,Q12824 2 +Tachycardia 0.530332128528075 1.1765901811901496 0.2393591186898396 1.0 1.0 22 P23786,O43772,P15924,P19022,Q8N335,P14923 6 +Generalized hyperreflexia 0.6391251892800931 1.1756657148039809 0.2397284842668523 1.0 1.0 5 P18074,P19447 2 +Decreased pulmonary function 0.6379113767391743 1.170394529024559 0.2418422363188701 1.0 1.0 5 P31749,Q12824 2 +Abnormal visual field test 0.6379113767391742 1.1703945290245583 0.2418422363188703 1.0 1.0 5 P31749,Q12824 2 +Heteronymous hemianopia 0.6379113767391742 1.1703945290245583 0.2418422363188703 1.0 1.0 5 P31749,Q12824 2 +Syncope 0.5415732156363131 1.170146737470756 0.2419419227783057 1.0 1.0 11 P14923,P15924,P31749,Q12824 4 +Postaxial hand polydactyly 0.5403049252003966 1.1673920463700431 0.2430520816475236 1.0 1.0 10 Q14739,Q9UBM7,O43924 3 +Hypertensive crisis 0.6066393760370754 1.1627613436123434 0.2449263450949026 1.0 1.0 6 P53992,Q92890 2 +Thin skin 0.5095550040290708 1.1589391762824952 0.2464809785870438 1.0 1.0 27 P17612,O14802,Q13126,Q96PU5,P18074,O75844,Q9H4L7 7 +Pericarditis 0.6352284040299985 1.1587458213498238 0.2465598073709927 1.0 1.0 5 Q9NZ08 1 +Distal sensory impairment 0.4281466256179656 1.1576240943951612 0.2470174722300553 1.0 1.0 40 O14802,O95831,P07384,O15270,Q6DD88,Q15046,Q15120,P18887,P39210,Q9BUK6 10 +Neurofibromas 0.5595682843886557 1.1567775453967248 0.2473632581559046 1.0 1.0 8 P21359,Q12824 2 +Steroid resistant nephrotic syndrome 0.6048040672349786 1.1544659836055389 0.2483091768004131 1.0 1.0 6 Q12769,Q92621,Q96J84 3 +Congenital malformation of the right heart 0.5590190606964677 1.1540984801710457 0.2484597964192387 1.0 1.0 8 Q6W2J9,P40855 2 +Deep venous thrombosis 0.7690026618147532 1.152479057863736 0.2491242705554766 1.0 1.0 3 P31749 1 +Spastic paraparetic gait 0.6633639142527535 1.1508016324997834 0.2498138530394187 1.0 1.0 4 P34897,O75787 2 +Vasculitis 0.535933074030282 1.150510476853904 0.2499336815881028 1.0 1.0 9 Q9Y3Z3,Q9NZ08 2 +Upper limb asymmetry 0.7682389694498404 1.149591628883387 0.2503121076186962 1.0 1.0 3 Q15555 1 +Decreased circulating level of specific antibody 0.5806009180512408 1.1488720317084429 0.2506087517859878 1.0 1.0 7 Q05655,Q9BV10,P17812 3 +Antineutrophil antibody positivity 0.662895228543767 1.148846970764638 0.2506190872406137 1.0 1.0 4 Q96J02,Q05655 2 +Ocular pain 0.7671818480762912 1.1455956260977076 0.2519625078933996 1.0 1.0 3 Q15043,Q99496 2 +Wide intermamillary distance 0.511182417379479 1.1436188355198602 0.252781746786213 1.0 1.0 26 P23786,Q96EK5,P61978,P22681,O14678,P21359,Q15555,Q9UBM7 8 +Long clavicles 0.7649917235726109 1.1373199987760512 0.255404537401273 1.0 1.0 3 Q14739 1 +Metatarsus valgus 0.7647616591433193 1.136450933073004 0.2557678897805835 1.0 1.0 3 P31749 1 +Simple ear 0.6298840655046825 1.135554399264398 0.2561431026934224 1.0 1.0 5 A1X283,Q96KP1,O60231 3 +Abnormal thalamic mri signal intensity 0.6292424721002382 1.132771481704005 0.2573102304381318 1.0 1.0 5 P31749,Q12824 2 +Decreased circulating acth level 0.6292424721002382 1.132771481704005 0.2573102304381318 1.0 1.0 5 P31749,Q12824 2 +Polymicrogyria 0.4008918233773827 1.128508207680901 0.2591053525420064 1.0 1.0 69 O14802,Q15392,Q16625,O75381,P34897,Q9NZ01,Q9Y487,Q08209,P36776,Q96F86,Q9NUQ7,Q01105,P40855,P23786,P37268,Q9H9S5,Q9Y5P6,Q96EK5,Q9Y4A5,P42345 20 +Bird like facies 0.5990254859482728 1.1283572928632275 0.2591690563262405 1.0 1.0 6 P18074,O75844 2 +Renal agenesis 0.3599724805990231 1.1268109045454895 0.2598224390759147 1.0 1.0 52 P61313,Q15392,P30153,P35606,O75306,Q15526,P08708,P46783,Q7LGA3,Q9UBM7,O43924 11 +Decreased number of peripheral myelinated nerve fibers 0.5338160183903594 1.1267917551240696 0.2598305372655187 1.0 1.0 13 P39210,P26358 2 +Metaphyseal cupping 0.9891518737672592 1.1246361065017556 0.2607432669056071 1.0 1.0 2 O95831 1 +Skin erosion 0.5748619667252415 1.1219459712741175 0.2618854127470427 1.0 1.0 7 P15924,P06132 2 +Abnormal morphology of myocardial trabeculae 0.6557124651430264 1.1189130922001371 0.26317721706247 1.0 1.0 4 P14923 1 +Joint contracture of the hand 0.3695537397699167 1.118711352209698 0.2632633005788518 1.0 1.0 46 O14802,Q15392,P57081,Q93074,P18074,O60828,Q6W2J9,O75844,Q9H4L7 9 +Sensorimotor neuropathy 0.4938025263382564 1.117222480357023 0.2638992109476108 1.0 1.0 29 P39210,P18887,O95831,P41440 4 +Abnormality of circulating leptin level 0.6547037756456396 1.114713022601471 0.2649734186799903 1.0 1.0 4 P31751 1 +Difficulty standing 0.5959658476092747 1.114540672732593 0.2650473058112119 1.0 1.0 6 Q15813,Q7RTS9 2 +Acquired abnormal hair pattern 0.5952055800888841 1.1111084118165728 0.2665216875424223 1.0 1.0 6 O60828,O75844,Q96CW1,P25054 4 +Myopathic facies 0.5944135859878559 1.1075333430794538 0.2680634046014711 1.0 1.0 6 Q9Y5P6 1 +Cleft soft palate 0.3744772256191462 1.1023003395108757 0.2703311218215234 1.0 1.0 59 Q15813,O14802,Q15392,P61313,P61978,Q6PGP7,Q9NWM8,P34897,P78318,Q9H9S5,P62266,O00571,Q6W2J9,P46783,P52788 15 +Asymmetric growth 0.5262049546909411 1.1011579921706485 0.2708279009790706 1.0 1.0 9 P31751,Q15555 2 +Coloboma 0.3676850436935061 1.1011252933191922 0.2708421301214572 1.0 1.0 46 P61978,P78318,Q9H9S5,Q92620,Q9Y5P6,Q9H553,O60828,Q9UBM7,Q6W2J9,Q96EK5,P31749,O43924 12 +Eeg with irregular generalized spike and wave complexes 0.7542233852939431 1.0967002215355948 0.2727724595816896 1.0 1.0 3 Q9NQZ5 1 +Abnormality of the calf musculature 0.527723755813875 1.0953274907791877 0.2733731878889247 1.0 1.0 14 Q14331,Q9H9S5,Q13642,Q9Y5P6,Q7Z392 5 +Malignant neoplasm of the central nervous system 0.4990592240650945 1.0942337484453102 0.2738524735471257 1.0 1.0 27 Q12824,P48735,P54277,O75874,Q9UPY3,P52701,P21359,Q15555,P49815,O60333 10 +Degeneration of the striatum 0.6494156493585814 1.0927103341845044 0.2745210009804093 1.0 1.0 4 Q9Y3Z3 1 +Irregular hyperpigmentation 0.389723721729496 1.0889387312885386 0.2761809049677479 1.0 1.0 66 P42858,P22681,P19447,Q7LGA3,Q14739,Q06136,A1X283,Q93074,Q9H1A4,P21359,Q9H4L7,O60333,Q6PGP7,P25054,P18074,O75844,P31749,Q96ST3,P52701,P49815,Q15555,P42345 22 +Thickened helices 0.5456342512750536 1.0888394060378677 0.2762247108791129 1.0 1.0 8 P19022,P22681 2 +Abnormal magnesium concentration 0.6189511263795463 1.0881773078429196 0.276516840410586 1.0 1.0 5 Q9NP81,Q15813 2 +Thickened nuchal skin fold 0.525426389427601 1.0870285868462195 0.2770241761526257 1.0 1.0 11 P22681,P61978,P40855 3 +Loss of eyelashes 0.7510336402332888 1.0846926755755 0.2780577929587258 1.0 1.0 3 P06132 1 +Alopecia of scalp 0.5657899872058759 1.079419483938755 0.2804007690808878 1.0 1.0 7 P18074,P06132,P19447 3 +Cafe au lait spot 0.3841410062755758 1.078973389268379 0.280599590567363 1.0 1.0 44 Q6PGP7,Q96ST3,P42858,A1X283,P22681,P49815,Q93074,P52701,Q9H1A4,P21359,Q7LGA3,P31749,P42345,O60333 14 +Platyspondyly 0.4604886943584013 1.0781626224382117 0.280961189141006 1.0 1.0 34 Q14739,O95831,P48735,Q7RTS9,Q32P28 5 +Increased bone mineral density 0.5072474987083662 1.0772376802286256 0.2813740956118451 1.0 1.0 24 Q13126,Q15392 2 +Cerebellar dysplasia 0.6453695294660884 1.0758958008746655 0.2819738601244383 1.0 1.0 4 P60953,Q9H9S5 2 +Abnormal circulating fatty acid anion concentration 0.5232501612721512 1.075836085147811 0.2820005707193753 1.0 1.0 11 O43772,Q16836,Q4G0N4 3 +Axonal loss 0.5649292639964789 1.0753878340123113 0.2822011263666066 1.0 1.0 7 P41440 1 +Fibroadenoma of the breast 0.6155814015783037 1.073597131497671 0.2830032838150662 1.0 1.0 5 Q05655,P31749 2 +Respiratory arrest 0.6150140861704195 1.071143659626694 0.2841048397470203 1.0 1.0 5 O43772 1 +Hemiparesis 0.5197956041929148 1.070189574148307 0.2845339862751692 1.0 1.0 18 Q12824,Q9NZ08,P49815,P03886,P42345 5 +Bifid uvula 0.4393639207965968 1.0687026558745956 0.2852036744200137 1.0 1.0 37 Q15813,Q15392,Q6PGP7,P61978,P78318,P34897,Q9H9S5,P62266,Q6W2J9,P52788 10 +Primary gonadal insufficiency 0.5180872089047571 1.0600060405365024 0.2891418512593811 1.0 1.0 9 Q13144,Q9NR50,O76024,Q9UI10,Q96MF7,P49770 6 +Abnormality of the scrotum 0.3630738734149409 1.057832456662686 0.2901318328253084 1.0 1.0 46 P42858,Q9BV10,Q93074,P18074,Q9UBM7,Q96EK5,Q15555,Q7LGA3,P31749,Q9Y4A5 10 +Abnormal fingertip morphology 0.496967074612384 1.0573888490573662 0.2903341585509074 1.0 1.0 26 P15924,P62266,Q93074,P55795,O14646,Q6W2J9,O75844,Q7LGA3 8 +Tachypnea 0.5155170116502189 1.055040379188256 0.2914068576716282 1.0 1.0 19 O14678,P50747,O43924 3 +Abnormal proportion of cd8 positive t cells 0.6401315789473774 1.0541579932496856 0.2918105885291018 1.0 1.0 4 Q05655,O95394,P49327 3 +Broad alveolar ridges 0.6400924332516733 1.05399567143856 0.2918848988994837 1.0 1.0 4 Q9UBM7 1 +Hypoglycemic coma 0.5160727660166783 1.049801205329058 0.2938095209799045 1.0 1.0 9 P31751,P13804 2 +Neoplasm of fatty tissue 0.5142630244447031 1.040636382522065 0.298044338992157 1.0 1.0 9 P27635,Q9BUK6,P31749 3 +Abnormal b cell subset distribution 0.636567258171131 1.0393869240132567 0.2986248228983359 1.0 1.0 4 P17812 1 +Abnormality of limb epiphysis morphology 0.4760758210529795 1.0347417954687022 0.3007895114990968 1.0 1.0 30 Q7RTS9,O95831 2 +Macroorchidism 0.5553491865282114 1.030562951935553 0.3027458170562731 1.0 1.0 7 P21359,Q93074 2 +Bloodstream infectious agent 0.605200083157217 1.028762926326132 0.3035910919923821 1.0 1.0 5 Q05655,P29144,P17812 3 +Hammertoe 0.5117221554931293 1.0260081300088064 0.304887751906119 1.0 1.0 18 Q8N0X7,Q99720,Q6W2J9,P39210,Q9UBM7 5 +Scarring alopecia of scalp 0.7351357725705332 1.0250470883725775 0.3053409697696017 1.0 1.0 3 P06132 1 +Submucous cleft of soft and hard palate 0.5012710317300273 1.0248205601953302 0.3054478633020689 1.0 1.0 23 Q15392,P62266,Q6W2J9,O75844,Q7LGA3 5 +Venous thrombosis 0.513500048648084 1.0247239497399556 0.3054934591441145 1.0 1.0 16 O75874,Q9NZ08,P48735 3 +Abnormality of the vertebral endplates 0.5540906873364274 1.0246820891379378 0.3055132168899162 1.0 1.0 7 Q7RTS9 1 +Abnormal anatomic location of the heart 0.5123507253353485 1.0165020144849264 0.3093903886968343 1.0 1.0 12 P19022,O75844,Q6W2J9,Q9NQ48 4 +Dilated third ventricle 0.7319960539296172 1.0133121159572551 0.3109111021340895 1.0 1.0 3 P26358,O75787 2 +Hodgkin lymphoma 0.5086237154267012 1.0120994641722163 0.3114904985728099 1.0 1.0 9 P40763,Q05655,Q07864,O95394 4 +Hypoglycemic seizures 0.5507572694117514 1.0091152707719828 0.3129193551418168 1.0 1.0 7 P31751 1 +Blurred vision 0.6290893095203482 1.0084594685363624 0.3132339362512399 1.0 1.0 4 P03886 1 +Advanced eruption of teeth 0.5106684871046753 1.0078077530011431 0.3135467631911859 1.0 1.0 12 P15924,O75844,Q9UBM7,P14923 4 +Posterior embryotoxon 0.5103297711885371 1.0077523038413043 0.3135733885717258 1.0 1.0 16 O75381,P53992,Q92890,Q12948,Q7LGA3,P40855 6 +Abnormal uvula morphology 0.3841649201895589 1.0024799998500906 0.3161118213568858 1.0 1.0 43 Q15813,Q15392,Q6PGP7,P61978,P78318,P34897,Q9H9S5,P62266,Q6W2J9,P52788 10 +Abnormality of skull ossification 0.5096441006317803 1.000569658827404 0.3170349048667238 1.0 1.0 13 Q32P28,Q14739,O75844 3 +Skeletal dysplasia 0.4004798690425666 1.000482928125603 0.3170768553583358 1.0 1.0 41 P21359,Q7RTS9,Q14739,O95831 4 +Proximal amyotrophy 0.5092870994251508 0.99828273637818 0.3181422764783863 1.0 1.0 14 O14979,Q16637,Q9H9S5,P35637 4 +Lymphedema 0.5079327420504881 0.9949325208660356 0.3197690846810155 1.0 1.0 16 Q14739,P26358,P22681,Q00535,P49815,P31749 6 +Neoplasm of the respiratory system 0.5075299992139972 0.9927796869210525 0.3208173311677416 1.0 1.0 16 P30154,Q01844,Q99496,Q9UPY3,P52701,P49815,P31749 7 +Microphallus 0.5965507269271414 0.9915253982692532 0.3214290967612465 1.0 1.0 5 Q96ST3,Q9Y4A5 2 +Infectious encephalitis 0.5256228536206805 0.9915239653478524 0.3214297960883745 1.0 1.0 8 Q14739 1 +Abnormal blistering of the skin 0.4978076585551826 0.9899470011650762 0.3222000245089886 1.0 1.0 22 Q06136,P15924,Q9NZ08,P06132,Q14574,Q9H4L7 6 +Central primitive neuroectodermal tumor 0.6233322288649739 0.9847134376674984 0.3247648502540858 1.0 1.0 4 Q9UPY3 1 +Nonketotic hypoglycemia 0.6230568637322595 0.9835791716319277 0.3253224702543227 1.0 1.0 4 P31751 1 +Expressive language delay 0.5042635138788152 0.9835110788953018 0.3253559653386184 1.0 1.0 10 Q8NB90 1 +Lagopthalmos 0.7235102793967286 0.98168040178405 0.3262573234437478 1.0 1.0 3 O75844 1 +Frontal balding 0.7227885563959126 0.9789961424578364 0.3275818855321866 1.0 1.0 3 O60828,Q96CW1 2 +Head titubation 0.565823566039642 0.9789065551058302 0.3276261529946289 1.0 1.0 6 P35637 1 +Astrocytosis 0.5437031739318874 0.9762267730972032 0.3289520984999146 1.0 1.0 7 P49815 1 +External ophthalmoplegia 0.5049422431780997 0.9761082445507244 0.3290108261686895 1.0 1.0 13 P03886 1 +Patchy palmoplantar hyperkeratosis 0.9444444444444492 0.9734803139079184 0.330314639624969 1.0 1.0 2 Q06136 1 +Eczema 0.4121630187180483 0.972038287625115 0.3310315012700795 1.0 1.0 39 Q14739,Q07864,P05165,P37287,P40763,P42224,P53992,P18074,Q14691,P19447,P50747,Q9UBM7 12 +Hyperventilation 0.591765147460809 0.970976823508984 0.3315598199463367 1.0 1.0 5 P50747 1 +Abnormal epiphyseal ossification 0.5028893937660002 0.9679985694789748 0.3330450841348618 1.0 1.0 16 Q14739,Q7RTS9 2 +Macule 0.3746338225873072 0.967283675496367 0.3334022421240612 1.0 1.0 65 P42858,P22681,P19447,Q7LGA3,Q06136,A1X283,Q93074,Q9H1A4,P21359,Q9H4L7,O60333,Q6PGP7,P25054,P18074,O75844,Q9NPE3,P31749,Q96ST3,Q05655,P52701,P49815,P42345 22 +Abnormal circulating progesterone level 0.5627831587614482 0.9652954343438768 0.33439685796032 1.0 1.0 6 Q9UI10,Q13144,Q9NR50,P49770 4 +Decreased circulating progesterone 0.5627831587614482 0.9652954343438768 0.33439685796032 1.0 1.0 6 Q9UI10,Q13144,Q9NR50,P49770 4 +Paroxysmal ventricular tachycardia 0.7184234929659672 0.9627829556740388 0.3356564559670163 1.0 1.0 3 P14923 1 +Tall stature 0.3385401738577512 0.9625947286370072 0.3357509439461847 1.0 1.0 50 P17612,P04350,O14802,P61978,P42858,P37287,Q9NWM8,P43034,Q93074,Q15334,Q9UPY3,P21359,P52788,Q7LGA3,P31749 15 +Severe photosensitivity 0.9411571334648288 0.96250431130437 0.3357963385772629 1.0 1.0 2 Q9UBM7 1 +Atrioventricular canal defect 0.5195923947258865 0.9623001245113336 0.3358988664673257 1.0 1.0 8 P17612,P19022,Q9UBM7 3 +Distal muscle weakness 0.3623292801604221 0.9616105296906958 0.3362452802031077 1.0 1.0 60 O95831,P41440,Q6DD88,P18887,P39210 5 +Poor wound healing 0.539366201026275 0.9560477588762896 0.3390481062522776 1.0 1.0 7 Q6DD88 1 +Abnormal erythrocyte sedimentation rate 0.495359355679698 0.9451477193350486 0.3445834659847604 1.0 1.0 9 Q05655,P28070,P14174 3 +Spinal cord tumor 0.935568704799479 0.9438969272065364 0.3452223224231925 1.0 1.0 2 P21359 1 +Neoplasm of striated muscle 0.4963923571414838 0.9435511946040616 0.3453990424562727 1.0 1.0 10 P21359 1 +Foot dorsiflexor weakness 0.4612346428984764 0.9396745088215483 0.3473845445060501 1.0 1.0 30 Q15813,Q14739,O15270,Q6DD88,Q15046,Q99720,P39210,O60333 8 +Colorectal polyposis 0.4937284802366012 0.936936769691088 0.3487910838459158 1.0 1.0 9 P31749,Q07864,Q9UPY3 3 +Abnormal scapula morphology 0.3406375306847684 0.9358681030815962 0.3493411017722665 1.0 1.0 52 P61313,Q14739,Q14331,Q7RTS9,Q9Y5P6,P19022,Q9H553,P08708,P46783,Q9Y487 10 +Abnormal peripheral nervous system physiology 0.3307096946847006 0.933158066270727 0.3507383621885955 1.0 1.0 48 P39210,Q9NQZ5,O95831 3 +Shock 0.7096669943910034 0.930377201285607 0.3521758185964219 1.0 1.0 3 P15924 1 +Poor fine motor coordination 0.5548330462457782 0.9297890004874096 0.3524803425475429 1.0 1.0 6 Q06787,Q8TC12,P42858 3 +Neoplasm of the tracheobronchial system 0.6094780347281297 0.9278399463446148 0.3534905994552051 1.0 1.0 4 Q9UPY3,P30154 2 +Psychomotor retardation 0.4198822597875268 0.9257853205617128 0.3545575573650783 1.0 1.0 37 P11498,P98155,O95831,P05165,P07942,Q96RQ3,Q9BV10,P18074,P19447 9 +Impaired t cell function 0.4927723911661137 0.9252143020675144 0.3548544454630518 1.0 1.0 10 P53992,Q92890,P17812 3 +Bone spicule pigmentation of the retina 0.4913323152582503 0.924882665193566 0.3550269445451564 1.0 1.0 9 Q15555,P50213 2 +Abnormal thyroid hormone level 0.7077900501158471 0.9234530577934614 0.3557711526131366 1.0 1.0 3 O14654 1 +Abnormal platelet volume 0.5113051906216532 0.9222492592696386 0.3563985742494542 1.0 1.0 8 Q14739,Q6PGP7 2 +Thin clavicles 0.7070586442477561 0.9207570693994442 0.3571772732849179 1.0 1.0 3 O75844 1 +Absent fingernail 0.5107384585342241 0.9195155843028776 0.3578259580067806 1.0 1.0 8 P15924,P14923 2 +Large intestinal polyposis 0.4926549045111422 0.9191121850085694 0.3580368964838742 1.0 1.0 11 P31749,Q07864,Q9UPY3,P25054 4 +Abnormal circulating fatty acid concentration 0.493991448022073 0.918646997080794 0.3582802415020516 1.0 1.0 15 O43772,Q16836,P40855,Q4G0N4 4 +Hypovolemic shock 0.9276791584483884 0.917744815480952 0.3587524792730585 1.0 1.0 2 P15924 1 +3 4 finger syndactyly 0.9276791584483884 0.917744815480952 0.3587524792730585 1.0 1.0 2 P15924 1 +2 3 finger syndactyly 0.9276791584483884 0.917744815480952 0.3587524792730585 1.0 1.0 2 P15924 1 +Agyria 0.6067485768028077 0.9166862099571064 0.3593070943228071 1.0 1.0 4 P43034,Q9H9S5 2 +Abnormality of the distal phalanges of the toes 0.5518071376115796 0.9163101741892156 0.3595042332007629 1.0 1.0 6 Q7LGA3 1 +Aplasia hypoplasia of the femur 0.4921549704776972 0.9108800361775818 0.3623585855978515 1.0 1.0 16 Q99575,O95831 2 +Proportionate short stature 0.4361006918439965 0.9101175440099262 0.362760523199316 1.0 1.0 34 Q15813,Q15392,Q14739,Q16836,Q7RTS9,Q13555 6 +Dystrophic fingernails 0.5084584334511781 0.9085251604344812 0.3636008267908148 1.0 1.0 8 P18074,O75844,P19447 3 +Abnormal brain lactate level by mrs 0.4912558230803513 0.907856460661688 0.3639540635574807 1.0 1.0 12 Q15046,P03886,O75306 3 +Generalized joint laxity 0.4898946501491731 0.905059774083844 0.365433721263571 1.0 1.0 11 P50454,Q93074,Q9BUK6,Q9Y487,P36776 5 +Gray matter heterotopia 0.4600846918065673 0.904445731864668 0.3657590979541716 1.0 1.0 29 P61978,O60231,P07942,P43034,Q96PU5,Q9H9S5,Q93074,Q9Y5P6,P19022,Q9UBM7,P35606,P31749 12 +Neuroendocrine neoplasm 0.490429080804144 0.9036188437780236 0.3661975457770912 1.0 1.0 12 P49815,P21359,O60333 3 +Beaking of vertebral bodies 0.4890394743600371 0.9007100452157997 0.367742506317763 1.0 1.0 11 P21359,Q7RTS9,Q6NUQ1 3 +Abnormal thoracic spine morphology 0.4738320880617638 0.8989296909391873 0.3686901119159425 1.0 1.0 25 O43776,O95831,Q7RTS9,Q99575,P18074,O75844 6 +Leukonychia 0.5269466312181501 0.8984743903828474 0.3689326924443135 1.0 1.0 7 P15924 1 +Abnormality of nail color 0.5269466312181501 0.8984743903828474 0.3689326924443135 1.0 1.0 7 P15924 1 +Abnormal ilium morphology 0.4865688485517762 0.8957840640009898 0.3703681026717818 1.0 1.0 19 Q7RTS9,O95831 2 +Scrotal hypoplasia 0.4846561957047433 0.893458187490154 0.3716118540093729 1.0 1.0 20 Q9BV10,Q93074,P18074,Q15555,Q9UBM7,Q9Y4A5 6 +Chromosomal breakage induced by ionizing radiation 0.5727928228254917 0.8899870586341954 0.3734728350428973 1.0 1.0 5 P31749,Q12824 2 +Neoplasm of the peripheral nervous system 0.4851387997319735 0.8879813835169061 0.3745507653934035 1.0 1.0 19 Q12824,P25054,Q15046,P21359,P49815,P31749,O60333 7 +Chest pain 0.4817341356002245 0.8870593867410972 0.3750469282185815 1.0 1.0 21 P25054,P37287,P19022,P21359,P49815,O60333 6 +Polycystic kidney dysplasia 0.4877004002446252 0.8856041723689809 0.3758308624436639 1.0 1.0 15 P23786,Q6PGP7,Q16134,P53992,Q92890,P13804,P49815 7 +Pancreatitis 0.481452380073707 0.8854883737240731 0.375893287417026 1.0 1.0 21 P03886,P05165,Q9NZ08 3 +Bloody diarrhea 0.5713143540827701 0.8837127484250961 0.3768512966957553 1.0 1.0 5 Q6PGP7,Q02241 2 +Midline defect of the nose 0.6968658227071653 0.8833217197122394 0.3770624719307089 1.0 1.0 3 P21359 1 +Hemimegalencephaly 0.9168310322156524 0.8820269479504294 0.3777622346849041 1.0 1.0 2 P49815 1 +Focal cortical dysplasia type ii 0.9168310322156524 0.8820269479504294 0.3777622346849041 1.0 1.0 2 P49815 1 +Hypoplastic ilia 0.4819586851419913 0.8778550284211817 0.3800223970665521 1.0 1.0 9 Q99575,Q7RTS9 2 +Pathologic fracture 0.4861712385743321 0.8775915295113471 0.3801654276961326 1.0 1.0 15 Q13126,P22681,Q6DD88,P22626 4 +Slowly progressive 0.3393841282084277 0.8774816125825305 0.3802251018097367 1.0 1.0 54 O95831,Q14331,P41440,Q5JTV8,Q99720,Q15526,Q9H553,O14979,Q15120,O75787,Q16637,O60333 12 +Cutaneous cyst 0.5698395483743678 0.8774600044177385 0.380236833601252 1.0 1.0 5 P49815 1 +Abnormal circulating estrogen level 0.4851747274838733 0.8767317771987814 0.3806323424477624 1.0 1.0 12 O14802,P31749,Q12824,P82650 4 +Brittle hair 0.4858955658984226 0.8761478766547475 0.380949648231361 1.0 1.0 15 P62266,P18074,O60828,Q9Y487,P19447,O75844 6 +Thick cerebral cortex 0.5961291385206133 0.8734751528970794 0.3824041436813119 1.0 1.0 4 Q9Y487 1 +Abnormality of thalamus morphology 0.4835314405834089 0.8729150606643924 0.3827093766352241 1.0 1.0 18 Q12824,Q9H9S5,Q96KP1,O75306,Q9Y5P6,Q9UPT5,Q15526,Q99496,P31749,Q9BU61 10 +Periventricular heterotopia 0.4823122988147181 0.8724053229496526 0.3829872976762318 1.0 1.0 10 P19022,Q96PU5,Q9UBM7,O60231 4 +Abnormal lung lobation 0.4848130165025323 0.8720117971462563 0.3832019417959342 1.0 1.0 16 Q14739,Q9UBM7,P31749 3 +Antiphospholipid antibody positivity 0.693521867806635 0.8710987839178553 0.3837002180728943 1.0 1.0 3 P42224,Q05655 2 +Cerebral hypomyelination 0.4845913595815703 0.8708412334099505 0.3838408477619452 1.0 1.0 16 P04350,Q13144,Q9NR50,Q9UI10,O75746,Q9H553,Q8NB90,O75340,P49770 9 +Esophageal neoplasm 0.5414348317627138 0.8702775126011937 0.3841487649701121 1.0 1.0 6 P25054 1 +Small earlobe 0.5004703426206245 0.8701225523933361 0.3842334342598725 1.0 1.0 8 P53992,Q92890,P52788 3 +Severe short limb dwarfism 0.6915138547036507 0.8637737765563963 0.3877121760817248 1.0 1.0 3 Q14739 1 +Demyelinating peripheral neuropathy 0.4830772835962723 0.8628502731490206 0.3882197941351453 1.0 1.0 16 Q13217,P41440,P18074,Q9Y3Z3,P03886 5 +Porencephalic cyst 0.5661444829407867 0.8618213786698211 0.3887858185886601 1.0 1.0 5 P07942 1 +Symphalangism affecting the phalanges of the hand 0.6908517314207927 0.8613609079515887 0.389039299434849 1.0 1.0 3 O60828 1 +Proximal symphalangism 0.6908517314207927 0.8613609079515887 0.389039299434849 1.0 1.0 3 O60828 1 +Retinal detachment 0.48002357324676 0.8601367389034223 0.3897136714618265 1.0 1.0 19 Q14331,Q9H9S5,Q9BV10,Q13045,Q9Y5P6,Q6W2J9,P31749 7 +Reduced circulating prolactin concentration 0.5652874486375561 0.858199922245585 0.3907820789634648 1.0 1.0 5 P31749,Q12824 2 +Multiple joint contractures 0.4744028794054517 0.8573160365078979 0.3912702481607133 1.0 1.0 22 P41440,Q9H9S5,Q93074,Q9Y5P6,P18074,P19447,Q9Y3Z3,O75844 8 +Abnormality of the hypothalamus pituitary axis 0.3741921489881049 0.8558887063961053 0.3920593423855361 1.0 1.0 70 O14802,P48735,Q8NI27,P82650,Q15813,Q07864,Q06787,P57081,Q93074,Q12948,Q9BUK6,Q7Z392,Q12824,P25054,O14654,P54277,O75874,P31749,Q15233,Q96MF7,Q96ST3,Q99496,P52701,P49815,Q4J6C6 25 +Duplication of hand bones 0.3297612584884047 0.8534697452690055 0.3933988585182799 1.0 1.0 51 Q14739,Q15067,P34897,Q13045,P53992,Q6W2J9,P46783,O43924,Q9UBM7,Q9NQ48 10 +Tetraplegia tetraparesis 0.3495581185549561 0.851494614436819 0.3944946537182852 1.0 1.0 45 O95831,Q7RTS9,P35637,Q9BSH4,Q4G0N4 5 +Abnormality of epiphysis morphology 0.3412266599816758 0.8499430774415317 0.3953567342328605 1.0 1.0 56 Q7RTS9,Q9UBM7,Q14739,O95831 4 +Dysdiadochokinesis 0.4806260251682746 0.8499314763461265 0.3953631844350993 1.0 1.0 16 P98155,P41440,Q6DKK2,P18887,Q9BUK6 5 +Cutaneous syndactyly of toes 0.5901597457525329 0.8493272317828016 0.3956992319776464 1.0 1.0 4 Q6W2J9,Q9H4L7 2 +Pulmonary cyst 0.5631258258694829 0.8490758314308764 0.3958390978238775 1.0 1.0 5 P15924 1 +Mesoaxial polydactyly 0.9063116370808756 0.8476823803629108 0.3966148815693584 1.0 1.0 2 O43924 1 +Broad eyebrow 0.4781524149513898 0.8455186073634617 0.3978213480831729 1.0 1.0 11 O14802,O14646,Q8NB90 3 +2 3 toe syndactyly 0.4462478489643991 0.8447747103414143 0.398236637147086 1.0 1.0 30 O14802,Q96PU5,P34897,P37268,Q93074,Q9UBM7,O43924 7 +Upper limb spasticity 0.4949758597704645 0.8438118239045567 0.3987745672084417 1.0 1.0 8 P37287,Q8N0X7,P35637,Q99720 4 +Neoplasm of the breast 0.4496987090189127 0.8399323029676504 0.4009463444881724 1.0 1.0 29 Q07864,P25054,P48735,P11802,Q05655,O75874,P52701,P21359,P31749 9 +Limb dystonia 0.478412802563564 0.8390851849515346 0.4014215090510216 1.0 1.0 13 P35637,Q99720,Q8NB90 3 +Deep plantar creases 0.5606033699222173 0.8384472973082806 0.4017795353336191 1.0 1.0 5 P61978,P42345 2 +Abnormal circulating nitrogen compound concentration 0.3209716722190371 0.8377678315572704 0.4021611087699845 1.0 1.0 48 P23786,Q16836,P05165,O43772,Q96RQ3,Q6NUQ1,P50747 7 +Anteverted ears 0.6843177070505331 0.8376184149303488 0.4022450470964578 1.0 1.0 3 Q6W2J9 1 +Abnormality of the metacarpal bones 0.3800859357754016 0.8376142706798179 0.4022473753770175 1.0 1.0 41 Q32P28,Q7RTS9,Q14739,O43924 4 +Lymphoproliferative disorder 0.5602767985424066 0.8370727705161154 0.4025516649913783 1.0 1.0 5 Q05655,P17812 2 +Severe short stature 0.4659327399806195 0.8363726520347615 0.4029452927836949 1.0 1.0 24 Q15392 1 +Arachnoid hemangiomatosis 0.4930449013716075 0.834587645135031 0.4039499208086194 1.0 1.0 8 P21359 1 +Paraganglioma 0.4930449013716075 0.834587645135031 0.4039499208086194 1.0 1.0 8 P21359 1 +Hemangioblastoma 0.4930449013716075 0.834587645135031 0.4039499208086194 1.0 1.0 8 P21359 1 +Medulloblastoma 0.4923003969007322 0.8310344282284248 0.4059541804547872 1.0 1.0 8 Q9UPY3,Q12824,P25054 3 +Thick hair 0.5117661742354516 0.8286421279909449 0.4073069420576574 1.0 1.0 7 Q9BUK6 1 +Abnormal brainstem mri signal intensity 0.4759916584328316 0.8282081032888037 0.407552655504968 1.0 1.0 17 P03886,O95831 2 +Coma 0.4239649807638704 0.827831171552913 0.4077661187118391 1.0 1.0 34 P05165,O43772,Q96RQ3,P31751,P13804,P50747 6 +Redundant neck skin 0.4908498735577091 0.824117050791011 0.409873052745751 1.0 1.0 8 A1X283,Q9Y487 2 +Abnormal glial cell morphology 0.3523405983475168 0.8230386841581274 0.4104859952749726 1.0 1.0 62 O95831,P42858,P48735,P37287,Q7KZN9,P35637,O75306,Q15526,P54277,O75874,P13804,P52701,P21359,P49815,P36776,P42345,P49770 17 +Aplasia hypoplasia of the cerebral white matter 0.4904920810588835 0.8224118912140008 0.4108425138869522 1.0 1.0 8 P03886 1 +Trichorrhexis nodosa 0.6800082326335009 0.8220301594515448 0.4110597322453655 1.0 1.0 3 P18074 1 +Intellectual disability progressive 0.4729649434787137 0.8193573258212359 0.4125825747160243 1.0 1.0 11 P18074,Q15067,O95831 3 +Falls 0.5094801803292471 0.8181885055427971 0.4132495575403483 1.0 1.0 7 Q8WVX9,Q5T8D3,O75787 3 +Cardiac diverticulum 0.5557249826144901 0.8179515675183119 0.4133848431216471 1.0 1.0 5 P54277 1 +Neoplasm of the male external genitalia 0.4725501393982891 0.8172696626744854 0.4137743397484321 1.0 1.0 11 Q14145,P31749,Q01844,Q9UPY3 4 +Central hypothyroidism 0.4725468438056738 0.8172530789452946 0.41378381489878 1.0 1.0 11 P27635,P31749,Q12824,O14654 4 +Ectropion 0.4743167132081736 0.8162250058126707 0.4143714574665886 1.0 1.0 14 O14802,P61978,P25054,P60953,P18074,P06132,P19447 7 +Progressive sensorineural hearing impairment 0.4711050082057406 0.8161815569734568 0.4143963035190428 1.0 1.0 10 P33993,O76024,P49736,Q7Z406,P00403,P03886 6 +Abnormal proportion of cd4 positive t cells 0.5290010995793577 0.8155040172035184 0.4147838660346514 1.0 1.0 6 Q05655,O95394,P49327,O75787 4 +Abnormal cartilage morphology 0.4730073438789434 0.8148140972879202 0.415178730279895 1.0 1.0 12 Q7LGA3,P48735 2 +Spinal deformities 0.5812603054365029 0.8135400322421776 0.4159085038946712 1.0 1.0 4 Q9Y5P6 1 +Elevated circulating long chain fatty acid concentration 0.8948060486522018 0.8104781156324813 0.4176654378326001 1.0 1.0 2 P40855 1 +Congenital muscular dystrophy 0.6767115260914405 0.8101453803903168 0.4178566250581599 1.0 1.0 3 Q9Y5P6 1 +Abnormal muscle fiber protein expression 0.507680493406871 0.8099715644667812 0.4179565189070475 1.0 1.0 7 Q9Y5P6,Q9H9S5 2 +Abnormality of circulating adrenocorticotropin level 0.487743154243783 0.8093262148464179 0.4183275311997891 1.0 1.0 8 P31749,Q99496,Q12824 3 +Palpitations 0.4728340492172542 0.8090295951011841 0.4184981232789295 1.0 1.0 16 P21359,P19022,P14923 3 +Autoimmune antibody positivity 0.4708903748619016 0.8089228828337541 0.4185595057000082 1.0 1.0 11 Q9Y5L0,P42224,Q05655,P53621,Q13546,Q96J02,O95394 7 +Lumbar hyperlordosis 0.4690595509739626 0.8079284485600284 0.4191317732409474 1.0 1.0 20 Q7RTS9,Q9H9S5,Q93074,Q9Y5P6,Q9H553,Q6W2J9 6 +Pituitary hypothyroidism 0.526883941389421 0.8062284185994973 0.4201111554364609 1.0 1.0 6 P31749,Q12824 2 +Breast carcinoma 0.4652177922486692 0.8059151964530316 0.4202917483566124 1.0 1.0 22 Q07864,P48735,O75874,P52701,P21359,P31749 6 +Abnormal muscle glycogen content 0.6754357119368447 0.8055556382520194 0.4204991132315587 1.0 1.0 3 Q9BUK6,P08237 2 +Diffuse cerebellar atrophy 0.5263384481817435 0.8038411323759853 0.4214887312786619 1.0 1.0 6 P18074,P19447 2 +Abnormal shoulder morphology 0.4476311681146271 0.803517673363125 0.4216755858762477 1.0 1.0 28 Q7RTS9,Q6W2J9,Q7LGA3,Q96PU5 4 +Abnormal brain positron emission tomography 0.5054996883697503 0.8000302518821334 0.4236932699494711 1.0 1.0 7 P31749,Q99496,Q12824 3 +Coarctation of aorta 0.3821660012103184 0.7974868102424834 0.4251683600815663 1.0 1.0 40 Q93074,P19022,O14678,P21359,Q9UBM7,P46783,Q9Y4A5 7 +Distal joint laxity 0.6729090978093704 0.7964823987019315 0.4257517020139387 1.0 1.0 3 Q9H553 1 +Abnormal diaphysis morphology 0.3561651805412359 0.7947760435269774 0.4267437887828509 1.0 1.0 65 P17612,Q15813,O14802,Q8N0X7,Q14739,Q13126,Q7RTS9,Q32P28,Q6W2J9,P21359,Q9Y487,Q7LGA3 12 +Hypertension associated with pheochromocytoma 0.4650264072632512 0.7935563230938409 0.4274537679442105 1.0 1.0 9 P21359 1 +Elevated calcitonin 0.4650264072632509 0.7935563230938391 0.4274537679442116 1.0 1.0 9 P21359 1 +Septate vagina 0.8882314266929741 0.7894011636206473 0.4298775760156665 1.0 1.0 2 Q9UBM7 1 +Hip pain 0.5487571911722358 0.7888239082870637 0.4302149337969627 1.0 1.0 5 O75844 1 +Synostosis of metacarpals metatarsals 0.6700205568855419 0.7861365494117358 0.4317874937867938 1.0 1.0 3 O60828 1 +Ulnar deviation of the hand or of fingers of the hand 0.4662484372851498 0.7856379623601488 0.4320796175196357 1.0 1.0 11 Q14739 1 +Flushing 0.4655256864835221 0.7820206606040878 0.434202431630007 1.0 1.0 11 P21359,P22681 2 +Hemihypertrophy 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 1.0 2 P31751 1 +Long penis 0.8856015779092681 0.7810096647411704 0.4347968104041086 1.0 1.0 2 O14802 1 +Severe muscular hypotonia 0.4580982340026668 0.7780165456826366 0.4365592591366671 1.0 1.0 23 O95831,Q9NWM8,O75381,Q9H9S5,O75746,Q01105,P40855 7 +Abnormal prolactin level 0.5203359733950681 0.7776457368888967 0.4367778899562304 1.0 1.0 6 P31749,Q12824 2 +Abnormally folded helix 0.4618722957547588 0.7772349256643261 0.4370201800424311 1.0 1.0 21 P23786,O43776,P37287,P62266,Q93074,P53992,Q92890,Q6W2J9,P36776 9 +Abnormality of the posterior pituitary 0.4807158006454314 0.7760033506389901 0.4377470075018159 1.0 1.0 8 P31749,Q99496,Q12824,O76024 4 +Prominent digit pad 0.4641190608406247 0.77432309039797 0.4387397522272898 1.0 1.0 19 P62266,Q93074,P55795,Q6W2J9,Q7LGA3 5 +Abnormal metacarpal morphology 0.4303111154436897 0.7722737325826556 0.4399523195226904 1.0 1.0 31 Q32P28,Q7RTS9,Q14739 3 +Atlantoaxial instability 0.8823142669296639 0.7705528972744333 0.4409719896428943 1.0 1.0 2 Q7RTS9 1 +Hemifacial spasm 0.5435338299921724 0.7671108805097444 0.4430155933596822 1.0 1.0 5 P31749,Q12824 2 +Sparse and thin eyebrow 0.4632917434524782 0.7657902863714945 0.4438010948759354 1.0 1.0 12 P15924,O14802,P21359,P14923 4 +Caesarian section 0.5687564534502869 0.7637463975794084 0.445018385428602 1.0 1.0 4 P33991,O14802 2 +Abnormality of retinal pigmentation 0.3639944143016481 0.7631388704648256 0.4453805805661164 1.0 1.0 70 O14802,O60231,O43172,O75381,P50213,Q15526,Q9BSH4,P19447,Q9NQ48,Q15067,Q16836,P28331,Q9BUK6,P03886,P40855,P25054,Q9H9S5,O75306,Q9Y5P6,P18074,Q96CU9,P31749,Q7KZN9,Q92620,Q9P0J0,Q15555 26 +Overlapping toe 0.4625233102489653 0.7607542523077294 0.4468038637105782 1.0 1.0 18 Q9Y4P8,Q9UBM7 2 +Titubation 0.4576645664106953 0.7572369064037326 0.4489079430115579 1.0 1.0 9 P35637 1 +Vertebral hypoplasia 0.4590578021615951 0.7562690538598578 0.4494878981999557 1.0 1.0 10 Q14739,O14802 2 +Flared nostrils 0.5400409631115233 0.7526541487739847 0.4516577695031243 1.0 1.0 5 P60953,Q96ST3 2 +Enchondroma 0.4566885834132863 0.7524396623102525 0.4517867023696329 1.0 1.0 9 O75874,P48735 2 +Ventricular fibrillation 0.8760683760683831 0.7507880110631372 0.4527802457651315 1.0 1.0 2 P15924 1 +Transposition of the great arteries 0.5395529522813107 0.7506384787139607 0.4528702571544942 1.0 1.0 5 O75844 1 +Atrophy degeneration affecting the brainstem 0.4579167727513191 0.7506274942887936 0.4528768696563823 1.0 1.0 10 Q13217,Q9Y4A5 2 +Abnormality of the humerus 0.4614574005499519 0.7494025853205794 0.4536145931972846 1.0 1.0 15 O14802,Q7RTS9,Q9BV10 3 +Neoplasm of the eye 0.458990320580926 0.746941331319108 0.4550989757158783 1.0 1.0 19 P18074,Q99496,P19447,P52701,P21359,P49815,P31749,O60333 8 +Retinal vascular tortuosity 0.4593828944249001 0.7423477037276365 0.4578766960394027 1.0 1.0 13 P53992,Q92890,P03886,O75306 4 +Limb girdle muscle weakness 0.4489047914300864 0.7394655404884535 0.4596243570294522 1.0 1.0 24 Q13126,Q9Y5P6,Q14331 3 +Aplasia hypoplasia involving the metacarpal bones 0.4461748646275917 0.7385531536918747 0.4601783794982306 1.0 1.0 25 Q7RTS9,Q14739 2 +Narrow nose 0.5104392329149317 0.7347761580128156 0.4624758296255522 1.0 1.0 6 Q9Y4A5 1 +Protruding ear 0.3594881765564823 0.7336942781064844 0.4631350866023467 1.0 1.0 42 P27635,P61978,Q06136,A1X283,Q9H9S5,Q93074,P18074,O60828,P19447,P21359,Q13555 11 +Aplasia hypoplasia affecting the fundus 0.451567822859559 0.7304454509847024 0.4651179448150584 1.0 1.0 22 O14802,P61978,P30153,P37268,Q9H9S5,Q93074,Q9Y5P6,Q12948 8 +Long thorax 0.6528502942273116 0.7252827280684467 0.4682785995350136 1.0 1.0 3 P17612 1 +Lactose intolerance 0.6521846327407668 0.7229473244501535 0.4697122471634047 1.0 1.0 3 P42345 1 +Sparse eyebrow 0.4028642308826392 0.7226185155552771 0.4699142896057275 1.0 1.0 35 O14802,Q96EK5,P61978,Q92643,P15924,O60828,Q14574,P21359,O75844,P14923 10 +Neck flexor weakness 0.6516013134481922 0.7209023579678135 0.4709695920000687 1.0 1.0 3 P35637 1 +Fetal ultrasound soft marker 0.4547941937629784 0.715484895570565 0.4743094708234425 1.0 1.0 16 P22681,P61978,Q2TAL8,P40855 4 +Abnormality of urine catecholamine concentration 0.4489522522979082 0.7145751854038592 0.4748715825893019 1.0 1.0 9 P21359 1 +Abnormal circulating copper concentration 0.5304535749526567 0.7132528960848885 0.4756892795700287 1.0 1.0 5 Q8NB90 1 +Gastritis 0.5051949018653377 0.7122385819465655 0.4763170492322603 1.0 1.0 6 Q13546,Q6PGP7,Q05655 3 +Megalocornea 0.4524264174230472 0.7115041329738979 0.4767718906121221 1.0 1.0 12 Q9Y5P6,A1X283,Q96EK5 3 +Hyperammonemia 0.4161095905460645 0.7111786352851891 0.4769735460975506 1.0 1.0 32 Q16836,P05165,O43772,Q96RQ3,Q6NUQ1,P50747 6 +Fine hair 0.4539625514165264 0.7111316586546265 0.4770026533707701 1.0 1.0 15 P18074,P22681,Q6PGP7,Q93074 4 +Wide cranial sutures 0.4482046803884421 0.7109323827314971 0.4771261378892848 1.0 1.0 9 O75844,Q93074 2 +Abnormal circulating proteinogenic amino acid concentration 0.4108463065540405 0.7076211225926733 0.4791805721023525 1.0 1.0 33 P05165,P41440,P78330,Q96RQ3,O14678,Q4G0N4,P11182 7 +Dicarboxylic aciduria 0.4472384687351324 0.7067777080115126 0.4797046297829546 1.0 1.0 22 O43772,P13804,O14678,P48735 4 +Increased serum pyruvate 0.4309265979923222 0.7036956371676302 0.4816223379099904 1.0 1.0 28 Q9BWD1,P11498,O95831,Q15046,P28331,O75306,Q86Y39,P03886,P36776 9 +Hypotelorism 0.4052595830307928 0.7036185988402963 0.4816703256246217 1.0 1.0 34 O43776,P57081,P55795,P18074,P21359,Q9BUK6,Q9Y4A5 7 +Nonprogressive 0.4841025206226069 0.7035424574420531 0.4817177571918509 1.0 1.0 7 Q9NQZ5 1 +Focal t2 hyperintense basal ganglia lesion 0.448634614313285 0.6979378690650865 0.4852160504474621 1.0 1.0 20 Q7KZN9,P28331,O75306,Q15526,Q9BSH4,Q96CU9,P03886 7 +Long toe 0.4639413784294194 0.6973403223567872 0.4855898392502269 1.0 1.0 8 P52788,P23786,O14802 3 +Neonatal hyperbilirubinemia 0.6446806718630649 0.6967536094793481 0.4859570026457041 1.0 1.0 3 P43034 1 +Abnormality of vitamin b12 metabolism 0.449232343138497 0.6956697876919157 0.4866356502653524 1.0 1.0 12 P41440 1 +Abnormality of the fetal cardiovascular system 0.5513303198371382 0.6954686984652519 0.4867616209330545 1.0 1.0 4 Q2TAL8 1 +Overweight 0.6436403094389099 0.6931419327699043 0.4882204845448188 1.0 1.0 3 Q8NI27 1 +Glycosuria 0.4445290508722518 0.6930657750725967 0.4882682746362685 1.0 1.0 9 P37287,P40763,Q15526,P13804,Q96MF7 5 +Multiple lipomas 0.5003241348644004 0.691428299468022 0.4892964249740443 1.0 1.0 6 Q9BUK6,P31749 2 +Vertebral wedging 0.6425517921736261 0.6893684173702209 0.4905914530241904 1.0 1.0 3 Q8WVQ1,Q96AY3 2 +Increased total bilirubin 0.5491948558698032 0.6872030016877582 0.4919548130768567 1.0 1.0 4 P23786 1 +Narrow nasal ridge 0.4613796918825919 0.6854532078719615 0.493057978172295 1.0 1.0 8 O75844 1 +Renal cell carcinoma 0.4310146572667049 0.6849921705000834 0.4933488616254893 1.0 1.0 27 Q92733,P25054,Q99496,Q9UPY3,P21359,P49815,P31749,O60333 8 +Abnormality of the pineal gland 0.6409075961854572 0.6836790150793163 0.4941778774514709 1.0 1.0 3 Q10471,Q15233 2 +Abnormal pineal morphology 0.6409075961854572 0.6836790150793163 0.4941778774514709 1.0 1.0 3 Q10471,Q15233 2 +Pineal cyst 0.6409075961854572 0.6836790150793163 0.4941778774514709 1.0 1.0 3 Q10471,Q15233 2 +Meningocele 0.4475978650575571 0.6833717973425142 0.4943719363844907 1.0 1.0 13 Q96ST3,Q9H9S5,P53992,Q92890,Q9Y5P6 5 +Bilateral external ear deformity 0.5478272026386486 0.6819218019895181 0.4952883986596781 1.0 1.0 4 P15924 1 +Diastema 0.497889378285711 0.681072366873442 0.4958257010532008 1.0 1.0 6 P17612,Q8TC12 2 +Flexion contracture of digit 0.3500982389278374 0.6792840075832957 0.4969579274923865 1.0 1.0 68 O14802,Q8N0X7,Q7RTS9,Q13642,Q96J02,A1X283,P15924,Q9BV10,P57081,Q93074,P52788,Q9H4L7,P27635,P18074,Q6W2J9,Q9Y4P8,P10412,O75844,P14923,Q8IWS0,O60828 21 +Abnormality of corneal thickness 0.4474774307451442 0.678299076972175 0.4975820838061051 1.0 1.0 15 Q15555,P50213 2 +T cell lymphoma 0.5216440011622481 0.6774454622909536 0.4981233618672256 1.0 1.0 5 Q05655,Q07864 2 +Neoplasm of the rectum 0.4471303427469899 0.6763362119291402 0.4988272065658887 1.0 1.0 16 Q07864,P54277,Q9UPY3,P52701,P31749 5 +Increased csf lactate 0.3126983418309025 0.676120110050501 0.4989643896398834 1.0 1.0 47 O95831,Q7KZN9,P28331,Q9BSH4,P39210,P03886 6 +Primitive neuroectodermal tumor 0.4454525127215185 0.6754973396346946 0.4993598410248461 1.0 1.0 19 P54277,Q9UPY3,P52701,P21359,Q15555,O60333 6 +Wormian bones 0.4454037113090059 0.6752422151005657 0.4995218899461282 1.0 1.0 19 Q32P28,Q9Y487,O95831,O75844 4 +Wide nasal ridge 0.5198120608222166 0.6700511792863152 0.5028251652714553 1.0 1.0 5 O14802,P61978 2 +Neonatal death 0.4451647946510519 0.6683164406074343 0.5039316210085292 1.0 1.0 14 Q14739,P13804 2 +Primary adrenal insufficiency 0.4451595467782512 0.6682902729307318 0.5039483211784535 1.0 1.0 14 Q12824,O75381,Q9Y2R9,P31749,P40855 5 +Abnormality of the tongue muscle 0.8494411571334782 0.6681843830015345 0.504015902945921 1.0 1.0 2 Q9Y5P6 1 +Decreased cervical spine mobility 0.8494411571334782 0.6681843830015345 0.504015902945921 1.0 1.0 2 Q9Y5P6 1 +Abnormal muscle fiber alpha dystroglycan 0.8494411571334782 0.6681843830015345 0.504015902945921 1.0 1.0 2 Q9Y5P6 1 +Fusion of the cerebellar hemispheres 0.8494411571334782 0.6681843830015345 0.504015902945921 1.0 1.0 2 Q9Y5P6 1 +Calf muscle pseudohypertrophy 0.8494411571334782 0.6681843830015345 0.504015902945921 1.0 1.0 2 Q9Y5P6 1 +Subcortical heterotopia 0.5438939842571789 0.6667897525851953 0.5049064392180478 1.0 1.0 4 P07942 1 +Subcortical band heterotopia 0.5438939842571789 0.6667897525851953 0.5049064392180478 1.0 1.0 4 P07942 1 +Absence of subcutaneous fat 0.4754367290001035 0.6651060179284646 0.5059826858257801 1.0 1.0 7 P18074,O14802,O75844 3 +Mottled pigmentation 0.6352119636959028 0.6640702745617234 0.5066453342683157 1.0 1.0 3 O75844 1 +Clonus 0.4085026252766586 0.6634816516787186 0.5070221269373727 1.0 1.0 32 P11498,Q8N0X7,P07384,P42858,Q9H9S5,P35637,Q99720,Q9Y5P6,O75787,Q9NVC6 10 +Congenital sensorineural hearing impairment 0.5177064866533123 0.6615755911543367 0.5082432549532165 1.0 1.0 5 Q15046,Q16740 2 +Low levels of vitamin d 0.4388434579148526 0.657346067104726 0.5109584217925931 1.0 1.0 10 P46783,Q10471,Q9NSD9 3 +Hyporeflexia of upper limbs 0.8454963839579182 0.656196001376868 0.5116980213452669 1.0 1.0 2 Q15067 1 +Constriction of peripheral visual field 0.4429430709607191 0.6561107896323878 0.5117528426712383 1.0 1.0 17 Q9H061,P50213,Q8TC12,Q15555,P40855 5 +Abnormality of the pulmonary vasculature 0.3872562871558048 0.6546600891060208 0.51268662690706 1.0 1.0 36 P27635,Q15392,Q6PGP7,P42858,P22681,Q6W2J9,Q7LGA3 7 +Dysmetria 0.3108206511808673 0.6532383462331985 0.5136026326028058 1.0 1.0 52 O14802,Q8N0X7,P98155,P41440,P34897,P18887,P21359,Q9BUK6 8 +Large placenta 0.631923571719579 0.6528219063606541 0.5138710992152644 1.0 1.0 3 O75844 1 +Myoclonic spasms 0.4903808230672159 0.6493439138486612 0.5161161073440916 1.0 1.0 6 P31749,Q12824 2 +Abnormal circulating carboxylic acid concentration 0.3856450317839516 0.6479937567641747 0.5169889883117724 1.0 1.0 86 P48735,P13804,Q14739,P00390,P41440,Q15046,P03886,P40855,P23786,Q6PGP7,P37268,Q96RQ3,O14678,Q02241,P11182,P11498,P05165,P78330,Q4G0N4 19 +Anal stenosis 0.470788344198607 0.6446674862356155 0.5191426908197441 1.0 1.0 7 Q12948 1 +Acne 0.4405728293905429 0.6436643988565408 0.5197930804691753 1.0 1.0 15 P17612,P53992,Q9NZ08 3 +Abnormal circulating lipid concentration 0.3503322544446056 0.642566513788457 0.5205054172565411 1.0 1.0 70 P23786,O14802,Q15392,Q14739,Q16836,P28070,O43772,P37268,Q13045,P31751,Q4G0N4,Q8N511,O75844,Q9UBM7,P40855 15 +Abnormality of facial adipose tissue 0.5375037464024595 0.6423899783312873 0.5206200050454912 1.0 1.0 4 O75844 1 +Skin ulcer 0.4132329936904014 0.641898432294618 0.520939132208057 1.0 1.0 30 P39210,Q14739,Q6DD88,P48735 4 +Mask like facies 0.4387848999236826 0.6398488604268167 0.5222708636814954 1.0 1.0 13 Q86U42,Q9H9S5,Q14331,O75787 4 +Arm dystonia 0.6279167319521823 0.6391908009601679 0.5226988157209074 1.0 1.0 3 P35637 1 +Vascular neoplasm 0.3900388903733901 0.6377631655893441 0.5236278604968931 1.0 1.0 35 P48735,P49815,O75874,P21359,Q7LGA3,Q9UBM7,P42345 7 +Abnormal femoral neck morphology 0.3842556093086495 0.6346347713483482 0.5256666447824168 1.0 1.0 36 Q7RTS9,O95831,Q99575 3 +Stillbirth 0.4354022008978226 0.6336878920422272 0.5262845283045112 1.0 1.0 11 Q14739 1 +Recurrent viral infections 0.4365491234805843 0.6334372343481255 0.5264481563971595 1.0 1.0 12 P29144,P17812,P42224,P33991,O95394 5 +Visual field defect 0.3533792746061416 0.6324144782329455 0.52711607571689 1.0 1.0 41 Q9H061,Q12824,P50213,O75306,P54277,P52701,Q8TC12,Q15555,P03886,P31749,P40855 11 +Xerostomia 0.4379672210056656 0.6308431759549921 0.5281430694716263 1.0 1.0 17 Q92804,Q14739 2 +Fatty replacement of skeletal muscle 0.4670979457516513 0.6285371454004316 0.5296521210145291 1.0 1.0 7 Q9H9S5,P22626,P51114 3 +Recurrent otitis media 0.4308378034317552 0.6279319622945606 0.5300485117289324 1.0 1.0 23 O14802,Q14739,P29144,Q05655,Q99496,Q6W2J9,Q9H1A4,Q9UBM7 8 +Abnormality of the upper arm 0.4323020616723654 0.6263145337337277 0.5311086553358053 1.0 1.0 22 O14802,Q7RTS9,Q9BV10,Q13642,O14979 5 +Systemic lupus erythematosus 0.4848791850083482 0.6263090083796874 0.531112278771835 1.0 1.0 6 Q9UJV9,Q05655,P29144 3 +Spastic paraplegia 0.3455291723560821 0.6253190264981993 0.5317616948849906 1.0 1.0 42 Q8N0X7,O95831,Q7KZN9,P07942,P28331,O75306,Q15526,Q9BSH4 8 +Leukodystrophy 0.3098895760964645 0.6239473725194692 0.5326621477831872 1.0 1.0 53 P04350,O14802,Q15067,P11498,Q7KZN9,Q15046,P28331,O75306,Q9BSH4,Q9Y3Z3,Q4G0N4,P03886 12 +Abnormality of the thoracic cavity 0.4353715410977438 0.6171067933762434 0.5371642881292302 1.0 1.0 16 Q92990,Q12824,Q05655,Q01844,P31749 5 +Severe viral infection 0.5062748162386399 0.6160182387374815 0.537882482342467 1.0 1.0 5 P29144,O95394,P17812 3 +Freckling 0.4345804619148227 0.6159511931899653 0.5379267326474715 1.0 1.0 14 P11802,P18074,P19447,P52701,P21359 5 +Venous malformation 0.8320184089414817 0.6157715532876263 0.53804530464327 1.0 1.0 2 P31749 1 +Very long chain fatty acid accumulation 0.5293393571786804 0.6115713424376849 0.5408214033315346 1.0 1.0 4 P40855 1 +Acidemia 0.4318374864320533 0.6106096183648498 0.5414580535636055 1.0 1.0 12 O14678,P48735 2 +Neuronal loss in the cerebral cortex 0.4804745283248764 0.6080064467411712 0.5431831981884001 1.0 1.0 6 P11498 1 +Brushfield spots 0.8293885601577861 0.6079848227080192 0.5431975400786562 1.0 1.0 2 P40855 1 +Iron deficiency anemia 0.503987707679843 0.6070022958938647 0.5438493884951208 1.0 1.0 5 Q10471,P25054 2 +Hand polydactyly 0.419964495114393 0.6059269617718885 0.5445632547647028 1.0 1.0 26 Q14739,Q15067,Q13045,Q9UBM7,O43924,Q9NQ48 6 +Progressive cerebellar ataxia 0.3797347930588939 0.6047428312630041 0.5453498843558449 1.0 1.0 36 P41440,P42858,Q7KZN9,P28331,P35637,O75306,Q15526,Q9BSH4,Q9BUK6 9 +Areflexia of lower limbs 0.4322616996514636 0.6016319321438123 0.5474191683944203 1.0 1.0 16 Q16637,Q15120,Q15067,Q13217 4 +Subcutaneous nodule 0.4310912229055173 0.6012846303083987 0.5476504247493201 1.0 1.0 19 P48735,P11802,P35637,Q9NZ08,O75874,P49815 6 +Multiple enchondromatosis 0.4788237339867018 0.6011803601258016 0.5477198641077015 1.0 1.0 6 P48735 1 +Lung adenocarcinoma 0.5259200194158609 0.5987899575680425 0.5493129599368609 1.0 1.0 4 P30154 1 +Generalized dystonia 0.6156428136425256 0.597976131306249 0.5498558595353404 1.0 1.0 3 P82663 1 +Bifid scrotum 0.4779849332719392 0.5977190630517428 0.5500274034682262 1.0 1.0 6 Q9UBM7 1 +Congenital nonbullous ichthyosiform erythroderma 0.5256046456332688 0.5976149886424182 0.5500968607440893 1.0 1.0 4 P18074 1 +Spastic dysarthria 0.442119716487145 0.5973761867513714 0.5502562488997156 1.0 1.0 8 O14802 1 +Congenital blindness 0.6149292995724951 0.595606495424148 0.5514381364073808 1.0 1.0 3 O15078,Q96MF7 2 +Abnormal csf metabolite level 0.3089744109544365 0.5953598529442902 0.5516029554858926 1.0 1.0 54 O95831,Q7KZN9,Q15046,P28331,O75306,Q9BSH4,Q9Y3Z3,P39210,P03886 9 +Turricephaly 0.4236149769956506 0.5930097549788416 0.5531746238737609 1.0 1.0 9 P53992,Q92890,Q13642 3 +Dysesthesia 0.6133970551475925 0.5905279383027555 0.5548367608662883 1.0 1.0 3 O15270 1 +Exercise induced myoglobinuria 0.4997084540914667 0.590227377855098 0.5550382196163306 1.0 1.0 5 Q9H9S5,P46020 2 +Slender long bone 0.429645409916558 0.5896167412271095 0.5554476253525613 1.0 1.0 15 Q15813,P37268,Q32P28,Q9H490,Q96J02,Q9Y487,Q96MF7 7 +Abnormal qt interval 0.4579089855407416 0.5887714428935729 0.5560146050019461 1.0 1.0 7 Q9Y5P6 1 +Carcinoid tumor 0.6127836897504013 0.5884988755794501 0.5561974883629168 1.0 1.0 3 P49815 1 +Abnormal b cell morphology 0.4252283265074484 0.5849316795021599 0.558593656293978 1.0 1.0 11 P42224,Q05655,Q9BV10,P17812 4 +Abnormal muscle fiber morphology 0.3322570120608098 0.58246233989882 0.5602553013813152 1.0 1.0 65 P23786,P61978,O95831,Q5JTV8,Q9NP81,Q86U42,Q9H9S5,P35637,Q9H2D1,Q99720,Q13642,Q15526,Q9Y5P6,Q9H553,P22626,O14979,Q9BUK6,P03886 18 +Large hands 0.4231375205407399 0.5822937924175371 0.5603688060578167 1.0 1.0 10 P21359 1 +Contractures of the joints of the upper limbs 0.3409620501883748 0.5813432028701789 0.5610091686771652 1.0 1.0 69 P23786,O14802,Q15392,P37268,P35637,Q99720,P57081,Q93074,P18074,Q6W2J9,O75844,Q7LGA3,Q9H4L7 13 +Profound global developmental delay 0.4257355016459253 0.5813081779144216 0.5610327699276487 1.0 1.0 12 O75381,P40855,P37268,P57081 4 +Long nose 0.4206151528529596 0.5789151211681683 0.5626464466408216 1.0 1.0 9 Q8NB90,Q93074 2 +Epiphyseal stippling 0.4238115113453965 0.5782075389150138 0.5631240095550571 1.0 1.0 11 Q14739,Q9UBM7 2 +Neuronal loss in basal ganglia 0.4552357048677149 0.5773165346750727 0.5637256459849613 1.0 1.0 7 O75306,P42858 2 +Low set posteriorly rotated ears 0.3469587795154557 0.5765378925803548 0.5642516651375975 1.0 1.0 72 P40855,Q15813,Q15392,P22681,P37268,P21359,O43924,Q15555,Q4J6C6,Q9UBM7,Q9NQ48 11 +Large for gestational age 0.4200058529634402 0.5760611681137467 0.5645738375203777 1.0 1.0 9 P31751 1 +Abnormality of t cell physiology 0.4255590683261286 0.5756380951310324 0.5648598261185178 1.0 1.0 13 P17812,P53992,Q92890,P21964,O95394 5 +Atypical absence seizure 0.8182117028270853 0.5752807486594994 0.5651014392194513 1.0 1.0 2 Q96CW1 1 +Limited elbow extension 0.425365759776364 0.5747105152451365 0.5654870946970365 1.0 1.0 13 Q7RTS9 1 +Abnormality of circulating glucocorticoid level 0.4250976087827127 0.5734243626115754 0.5663573986094808 1.0 1.0 13 P17612,Q12824 2 +Abnormal calcium phosphate regulating hormone level 0.4227376301553524 0.5731222804235069 0.5665619024224209 1.0 1.0 11 P21359 1 +Morphological abnormality of the pyramidal tract 0.4245545643705781 0.5724051399215062 0.5670475344919832 1.0 1.0 20 O95831 1 +Episodic hyperhidrosis 0.4205153987184934 0.5699495570718531 0.568711911431218 1.0 1.0 10 P21359 1 +Aplasia hypoplasia of the eyebrow 0.3310707161784111 0.568906764582021 0.5694194144396254 1.0 1.0 43 O14802,Q4G0J3,P61978,Q96EK5,Q92643,P15924,O60828,Q14574,Q9H1A4,P21359,P52788,O75844,P14923 13 +Joint contractures involving the joints of the feet 0.4202322092912615 0.5686198426342483 0.5696141559355286 1.0 1.0 10 P14923,P15924,Q6W2J9,Q8IWS0 4 +Somatic mosaicism 0.8145956607495071 0.5648399331904302 0.5721826426874239 1.0 1.0 2 P61586 1 +Abnormal vascular physiology 0.2985147775533808 0.563563925388318 0.5730509435504536 1.0 1.0 51 Q14739,Q9NWM8,Q9NZ08,Q93074,O14678,Q9Y3Z3,P21359,O75844,P03886,P31749 10 +Wide anterior fontanel 0.4202854001505124 0.5631526158683978 0.5733309656124466 1.0 1.0 22 A1X283,Q93074,Q32P28,P13804,P42345,Q9Y487,P40855 7 +Enamel hypoplasia 0.4234182342559828 0.5617198459374729 0.5743069105772041 1.0 1.0 14 P61586,P18074,P19447,P21359,P36776 5 +Abnormal enchondral ossification 0.4061096009770631 0.5606494861305846 0.5750365092641054 1.0 1.0 28 Q7RTS9,Q14739 2 +Delayed ossification of carpal bones 0.8129520052596972 0.5601174721333545 0.5753993135810016 1.0 1.0 2 P36776 1 +Duplication involving bones of the feet 0.4232408829469854 0.5587602431985903 0.5763253587657018 1.0 1.0 18 Q14739,Q9UBM7,O43924,Q9NQ48 4 +Occipital meningocele 0.4679912103207672 0.5568700295335676 0.5776162328253978 1.0 1.0 6 P53992,Q92890 2 +Right ventricular dilatation 0.8116370808678449 0.5563501534431872 0.5779715076834946 1.0 1.0 2 P19022 1 +Onycholysis 0.4909245596059671 0.5561999194661396 0.5780741942817584 1.0 1.0 5 P06132 1 +Gynecomastia 0.4225779736309888 0.5554690556442702 0.5785738702352989 1.0 1.0 18 A1X283,O14802,P31751,P31749 4 +Short femur 0.4676173384029568 0.5553563948936213 0.5786509120325249 1.0 1.0 6 O00116,O14802,Q9BV10 3 +Dilatation of the ventricular cavity 0.8106508875739821 0.5535309248448239 0.5798999107197251 1.0 1.0 2 Q9Y5P6 1 +Dilation of virchow robin spaces 0.8106508875739644 0.5535309248447736 0.5798999107197595 1.0 1.0 2 P43034 1 +Long foot 0.4142700843710002 0.549347488032431 0.582767003802457 1.0 1.0 9 P21359 1 +Melena 0.8086785009861878 0.5479086993663066 0.583754595182201 1.0 1.0 2 Q02241 1 +Cyanosis 0.4207766472591612 0.5452523035351157 0.5855800032708021 1.0 1.0 17 O43772,O75844 2 +Hypogonadotropic hypogonadism 0.4085804875573127 0.5435126943029258 0.5867768530427167 1.0 1.0 26 O14802,P22681,P03886,Q12824 4 +Abnormal oral frenulum morphology 0.4195862884517888 0.5433667520164664 0.5868773127300242 1.0 1.0 14 P17612,O43924 2 +Diffuse white matter abnormalities 0.4144479492344384 0.5416135402356839 0.5880847621129695 1.0 1.0 10 Q9Y5P6,Q15526,O75306 3 +Intestinal polyp 0.4157468564290273 0.539719856030171 0.58939024441042 1.0 1.0 22 Q07864,P25054,P54277,Q9UPY3,P52701,P31749,P42345 7 +Toe walking 0.4170170212842553 0.5395324013301875 0.5895195460134002 1.0 1.0 21 Q86UE8,P35637,O95831 3 +Eversion of lateral third of lower eyelids 0.8053911900065864 0.5385869969976151 0.590171861710304 1.0 1.0 2 P61978 1 +Lymphopenia 0.4076530014555033 0.5385028945822652 0.590229907292648 1.0 1.0 26 Q6PGP7,P29144,P28070,P49327,P17812,Q9NRZ9,P42224,Q05655,Q9BV10,Q13546,O95394 11 +Retinal dysplasia 0.4288957136237071 0.5384604759684247 0.5902591846566032 1.0 1.0 8 O43924 1 +Reduced systolic function 0.5973961339821414 0.5383615903702406 0.5903274381784438 1.0 1.0 3 P15924 1 +Depletion of mitochondrial dna in muscle tissue 0.5968431437027197 0.536588387000626 0.5915519675658636 1.0 1.0 3 Q9UBX3,P53597 2 +Abnormal midbrain morphology 0.4450815963212452 0.5343173948711382 0.5931219593594435 1.0 1.0 7 O43924 1 +Gastrostomy tube feeding in infancy 0.4013560824283598 0.5341567519630683 0.5932330879451506 1.0 1.0 28 P67870,P30153,P37268,P35637,Q9BV10,Q99720,Q8NB90,Q01105,Q9H490,Q96J02,Q08209,P36776 12 +Decreased proportion of cd4 positive helper t cells 0.4850333342983934 0.5337043140823603 0.5935461239475994 1.0 1.0 5 Q05655,O95394,P49327 3 +Nail dysplasia 0.3943158939636439 0.5313388970236982 0.595183955598134 1.0 1.0 30 P17612,O96028,P15924,Q99575,Q13642,P18074,P19447,Q9H1A4,Q9NPE3,Q9Y4A5 10 +Increased intramyocellular lipid droplets 0.4436156110651497 0.528180059997338 0.5973743677557957 1.0 1.0 7 Q9BUK6 1 +Fluctuations in consciousness 0.4096219733168236 0.5279120065571402 0.5975604109182358 1.0 1.0 9 P03886,O75306 2 +Deviated nasal septum 0.8011176857330897 0.5265613999011712 0.5984982031912567 1.0 1.0 2 P21359 1 +Confetti like hypopigmented macules 0.8011176857330874 0.5265613999011646 0.5984982031912613 1.0 1.0 2 P49815 1 +Symphalangism of middle phalanx of finger 0.8011176857330645 0.526561399901101 0.5984982031913055 1.0 1.0 2 O60828 1 +Abnormality of the proximal phalanx of the thumb 0.8011176857330645 0.526561399901101 0.5984982031913055 1.0 1.0 2 O60828 1 +Abnormality of female external genitalia 0.3673585562651607 0.5248165690136527 0.5997107121588197 1.0 1.0 36 Q15392 1 +Abnormality of exocrine pancreas physiology 0.4163611555076011 0.5237493139081056 0.6004529113219317 1.0 1.0 17 P21266 1 +Recurrent hand flapping 0.504800039926065 0.521673447151929 0.6018977153670866 1.0 1.0 4 Q06787,P55795 2 +Unusual infection by anatomical site 0.4128659147132947 0.5205919175962234 0.6026510809026382 1.0 1.0 12 Q14739 1 +Progressive hearing impairment 0.4121560810675451 0.517289646952992 0.6049539801078674 1.0 1.0 12 P33993,O76024,P49736,Q7Z406,P00403,P03886 6 +Esophageal carcinoma 0.7968441814595657 0.5146428325256293 0.6068026283034413 1.0 1.0 2 P25054 1 +Recurrent herpes 0.7968441814595648 0.5146428325256276 0.6068026283034424 1.0 1.0 2 P29144 1 +Abnormality of the periungual region 0.5894159148252587 0.5129761628001456 0.6079679951431007 1.0 1.0 3 P49815 1 +Entropion 0.4097463768272649 0.512433519204046 0.6083476369728622 1.0 1.0 11 P18074,O14802,O75844,P19447 4 +Immunologic hypersensitivity 0.3907623566240751 0.5111782979226437 0.6092262135841444 1.0 1.0 30 P49327,Q9Y5L0,P22681,P40763,Q9NZ08,P53992,Q92890,Q9UJV9,Q93009,P18074,O14646,P21964,O95394,P42345 14 +Abnormal glomerular mesangial cellularity 0.7955292570677372 0.510997505786905 0.6093528032875419 1.0 1.0 2 Q96J84 1 +Abnormality of the diencephalon 0.3902190318144794 0.5081146105494344 0.6113729694824519 1.0 1.0 30 Q12824,O75306,Q15526,Q9UPT5,Q9Y5P6,P19022,P31749,O43924 8 +Hyperpituitarism 0.4123202053709755 0.5073573059469301 0.6119041363809199 1.0 1.0 19 O14802,Q12824,Q06787,Q99496,Q9BUK6,P31749,Q96MF7,P82650 8 +Cranial asymmetry 0.4553153956676086 0.5061870043745021 0.6127253771626975 1.0 1.0 6 O14802,P40855 2 +Abnormality of vitamin d metabolism 0.4083531815696136 0.5060225132512284 0.61284084525561 1.0 1.0 11 P46783,Q10471,Q9NSD9 3 +Paraplegia 0.3156099841540911 0.505303263772779 0.6133458508111089 1.0 1.0 44 Q8N0X7,O95831,Q7KZN9,P07942,P28331,O75306,Q15526,Q9BSH4 8 +Increased intracranial pressure 0.4104170659251445 0.5014834727915192 0.6160309064665281 1.0 1.0 20 Q12824,P25054,Q9NZ08,P54277,P52701,P31749 6 +Holoprosencephaly 0.4094044792133935 0.4993601043256747 0.6175257196677322 1.0 1.0 13 Q9Y5P6 1 +Abnormal placental size 0.49833869928554 0.4987719858363645 0.6179400251650338 1.0 1.0 4 O75844 1 +Hydrocephalus 0.3481766179424286 0.4986721791022002 0.6180103470069871 1.0 1.0 77 P23786,Q15392,O14802,Q12824,P07942,P31749,Q93074,Q9Y5P6,P18074,P53992,P21359,P49815,Q9UBM7,P40855 14 +Weakness of muscles of respiration 0.3800442630404233 0.4923306213278973 0.6224856363545452 1.0 1.0 32 O95831 1 +Hereditary nonpolyposis colorectal carcinoma 0.4031669362635653 0.4898528018006505 0.6242380636786045 1.0 1.0 10 P31749,P52701 2 +Early onset of sexual maturation 0.3566402943383346 0.4896301634313935 0.6243956280494429 1.0 1.0 37 P42858,P48735,P49815,Q13045,O75874,P21359,Q7LGA3,Q9UBM7 8 +Basal ganglia calcification 0.4172445658537535 0.4878188578692407 0.6256781528172022 1.0 1.0 8 P03886,Q9Y3Z3 2 +Complete duplication of phalanx of hand 0.4727757704628443 0.4878146497062959 0.6256811337976389 1.0 1.0 5 P34897 1 +Bilateral polymicrogyria 0.4171499507379782 0.4874129706543075 0.6259657035560113 1.0 1.0 8 P67870,Q00610,Q01105,Q08209 4 +Narrow nasal bridge 0.4943647631328466 0.4848628363037142 0.6277736460483274 1.0 1.0 4 Q93074 1 +Polyuria 0.4709200096453153 0.4809817924024734 0.6305294393458154 1.0 1.0 5 Q9NQ48 1 +Cranial nerve compression 0.4041673908885616 0.4804923958150759 0.6308773089610864 1.0 1.0 12 P21359,P22626 2 +Large face 0.3285202505759275 0.4791273168548001 0.6318480574293983 1.0 1.0 69 P42858,Q92890,Q7LGA3,P17612,Q9BV10,Q93074,Q9H490,Q9BUK6,P52788,P21359,O43924,P27635,P61978,Q86UE8,P25054,O00571,Q6W2J9,P31749,Q15233,Q96ST3,Q92643,Q13045,P53992,O60828,Q10471 25 +Abnormal circulating carbohydrate concentration 0.3691426646944594 0.4774663161397632 0.633030101138788 1.0 1.0 34 Q9BWD1,P11498,O95831,Q15046,P28331,O75306,P03886 7 +Ureteral duplication 0.4312347590657659 0.4771247646268882 0.6332732810726203 1.0 1.0 7 O75844 1 +Type i diabetes mellitus 0.4024307140327067 0.4725861523193114 0.6365084638799687 1.0 1.0 12 Q13217,P40763,P42224,Q96J02,P03886 5 +X linked recessive inheritance 0.2968795154683513 0.4724249529181507 0.6366234969914757 1.0 1.0 55 P27635,O95831,P37287,P78318,Q93074,Q13642,O14654,O60828,O00571,P46020,O75787,P52788,Q8IWS0 13 +Abnormality of the umbilical cord 0.4298317775444026 0.4714318130671771 0.6373324022615807 1.0 1.0 7 O75844 1 +Limb girdle muscle atrophy 0.4027308251601706 0.4686545433885716 0.6393165836243626 1.0 1.0 13 Q9H9S5,O14979,Q14331,Q13642 4 +Abnormality of vitamin b metabolism 0.4035591051512515 0.4682795104938888 0.639584718925041 1.0 1.0 14 P41440 1 +Abnormality of the dorsal column of the spinal cord 0.573655602152493 0.4642007117820809 0.6425039512984894 1.0 1.0 3 Q8WVX9 1 +Increased muscle glycogen content 0.7777777777777953 0.462838274543337 0.6434802942295859 1.0 1.0 2 Q9BUK6 1 +Abnormal blood transition element cation concentration 0.4002230193563428 0.462585945049047 0.6436611849596159 1.0 1.0 12 Q6PGP7,Q8NB90,Q9Y487,Q02241 4 +Brain imaging abnormality 0.3295505539638643 0.4618433001682034 0.6441936969571795 1.0 1.0 41 O14802,Q12824,Q15046,Q9BV10,Q96CW1,O75306,Q15526,P21359,P03886,P31749 10 +Abnormality of salivation 0.3026985654912552 0.4617017274825768 0.6442952321010895 1.0 1.0 45 O14802,Q14739,Q92804,P34897,P35637,Q93074,P55795 7 +Abnormal cell proliferation 0.5724552655882675 0.4605641077481902 0.6451113674641649 1.0 1.0 3 P17812 1 +Cutaneous photosensitivity 0.398402482078588 0.4594569461121968 0.6459060627074142 1.0 1.0 23 Q06136,P37268,P18074,P06132,Q9Y3Z3,Q9UBM7 6 +Alveolar rhabdomyosarcoma 0.7761341222879665 0.4584818177117242 0.6466063224481657 1.0 1.0 2 Q9UPY3 1 +Abnormal pleura morphology 0.3943971109175007 0.4571333282378347 0.647575216276193 1.0 1.0 25 Q14739,P22681,Q9NZ08,Q99496,Q9UPY3,P14174,P49815 7 +Basal cell carcinoma 0.4019955554500919 0.4553766839392658 0.6488382664529317 1.0 1.0 17 P25054,Q05655,P18074,P54277,Q9UPY3,P52701,Q9H1A4,P19447 8 +Osteosarcoma 0.3957398039998028 0.454345378579028 0.6495802595590598 1.0 1.0 24 Q13126,P61313,P08708,P46783 4 +Nodular goiter 0.5701593672435481 0.4536404934051138 0.6500876032947951 1.0 1.0 3 Q9UPY3 1 +Abnormal circulating proteinogenic amino acid derivative concentration 0.4016135428021347 0.4535942620390023 0.6501208841652959 1.0 1.0 17 P11498,Q15046,P03886 3 +Abnormality of the endometrium 0.3928783716461493 0.4524689229771369 0.6509312043433151 1.0 1.0 9 Q07864,P31749 2 +Dolichocephaly 0.3911976279503735 0.451760334427984 0.6514416477865428 1.0 1.0 26 P61978,O75381,Q7RTS9,Q96J02,Q4J6C6,P31749,P40855 7 +Steppage gait 0.4000121085401879 0.4509057681504937 0.6520574660689804 1.0 1.0 20 O15270,Q15046,Q6DD88,Q15120,O60333 5 +Unconjugated hyperbilirubinemia 0.5688949305166442 0.4498456221145833 0.6528217592222101 1.0 1.0 3 P37287 1 +Abnormality of fontanelles 0.3009615330718541 0.4485328773406741 0.653768664032 1.0 1.0 45 Q15813,O14802,O75381,A1X283,O75844,Q93074,Q32P28,P13804,P42345,Q9Y487,P40855 11 +Self mutilation 0.3938221899926339 0.447992609887213 0.6541585300728479 1.0 1.0 10 Q4G0J3,Q9UBM7,Q6W2J9 3 +Abnormality of skeletal muscle fiber size 0.400194058575661 0.4478073835073182 0.6542922142585024 1.0 1.0 16 O95831 1 +Lower limb metaphyseal irregularity 0.4835526315789601 0.4477383783672059 0.6543420204531569 1.0 1.0 4 Q9Y3A5,P26373,Q5F1R6 3 +Adipose tissue loss 0.3916121715297226 0.4468873767040596 0.6549563787485442 1.0 1.0 9 P18074,O14802,O75844 3 +Recurrent bronchopulmonary infections 0.4610175355509624 0.4450688183038426 0.6562700220257442 1.0 1.0 5 P18074 1 +Abnormality of the ribs 0.308874715352082 0.4441719378833824 0.656918279220313 1.0 1.0 62 Q32P28,Q7RTS9,Q14739,O95831 4 +Juvenile aseptic necrosis 0.4387780675120508 0.4422388312178235 0.6583163893199944 1.0 1.0 6 Q8IWS0 1 +Congenital malformation of the left heart 0.5659363439095775 0.4410174758216682 0.6592003454067896 1.0 1.0 3 O14802 1 +Muscular dystrophy 0.3911261728976823 0.4405739568340852 0.6595214602489405 1.0 1.0 25 Q14331,Q5JTV8,Q9H9S5,Q13642,Q9Y5P6,P22626,O14979 7 +Generalized hyperkeratosis 0.4594834946207545 0.4395910775690511 0.6602333041117618 1.0 1.0 5 O75844 1 +Abnormality of the pancreas 0.3360838853756868 0.4377047999896807 0.6616002895055164 1.0 1.0 75 Q14739,Q6PGP7,P05165,P25054,Q9UJW0,P40763,P11802,Q01844,Q9NZ08,P21266,P54277,Q4G0N4,P14174,P52701,Q9NPE3,P03886,Q96MF7,P11182 18 +Increased muscle lipid content 0.3893908178080922 0.4371408196289645 0.662009225523613 1.0 1.0 9 P23786,Q9BUK6 2 +Neonatal insulin dependent diabetes mellitus 0.7679158448389207 0.4369728056760388 0.6621310701095324 1.0 1.0 2 P40763 1 +Nocturnal hypoventilation 0.5644299884594444 0.4365505785735109 0.6624373108666064 1.0 1.0 3 P61978 1 +Abnormality of corneal size 0.3374838648982968 0.4365215245788978 0.662458385766781 1.0 1.0 39 Q9NWM8,A1X283,Q13045,Q9Y5P6,P18074,P19447,Q6W2J9,Q96EK5,Q15555,P36404 10 +Heterogeneous 0.2920859542151263 0.4363822774557436 0.6625593951822306 1.0 1.0 46 Q16836,P15924,Q96RQ3,Q12948,P49815,Q15555,P03886 7 +Duodenal adenocarcinoma 0.5641149979632992 0.4356189216290077 0.6631132400586506 1.0 1.0 3 P25054 1 +Adenocarcinoma of the small intestine 0.5641149979632992 0.4356189216290077 0.6631132400586506 1.0 1.0 3 P25054 1 +Abnormal soft palate morphology 0.322909954776646 0.4350556514724763 0.6635220329807534 1.0 1.0 69 Q15813,O14802,Q15392,P61313,P61978,Q6PGP7,Q9NWM8,P34897,P78318,Q9H9S5,P62266,O00571,Q6W2J9,P46783,P52788 15 +Metamorphopsia 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Photopsia 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Choroidal melanoma 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Uveal melanoma 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Mydriasis 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Inferior lens subluxation 0.7669296515450352 0.4344228589576011 0.663981401201186 1.0 1.0 2 Q99496 1 +Renal hypoplasia 0.3799539669090764 0.4343203476035629 0.6640558299938897 1.0 1.0 29 P53992,O60828,P57678,Q6W2J9,Q9UBM7,O43924,Q9Y4A5 7 +Protrusio acetabuli 0.5636303847418573 0.4341871988423575 0.6641525081501816 1.0 1.0 3 O75718,Q96AY3 2 +Platybasia 0.4203042140727697 0.4333113378409163 0.6647886024431302 1.0 1.0 7 P53992,Q92890 2 +Abnormal growth hormone level 0.3851493824167708 0.4328728110558257 0.6651071733767577 1.0 1.0 27 Q15813,O14802,Q07864,Q12824,P57081,Q4J6C6 6 +Shoulder girdle muscle atrophy 0.4783739916483635 0.4303494484677228 0.6669414619727316 1.0 1.0 4 Q14331 1 +Abnormal subarachnoid space morphology 0.3649412627370721 0.4288039105381405 0.6680659327768486 1.0 1.0 33 O43776,O95831,Q9BV10,Q93074,P19022,Q01105,P03886 7 +Abnormal bronchus physiology 0.4777911044551653 0.4284088103101904 0.6683535114332515 1.0 1.0 4 P18074 1 +Abnormal insulin level 0.3904641342143933 0.4281022363654043 0.6685766886677256 1.0 1.0 24 Q16836,P50213,O75844,P31751,Q15555 5 +Kyphoscoliosis 0.2905338590402856 0.420974965856512 0.6737733623459432 1.0 1.0 55 P04350,O14802,Q8N0X7,Q9NWM8,A1X283,Q99575,O75844,Q15526,P18074,Q6W2J9,P21359,P10412,P52788,Q9Y487,P31749 15 +Oculogyric crisis 0.3892849780660534 0.4204504592569329 0.6741564129305058 1.0 1.0 11 P67870,Q00610,P61457,Q01105,Q08209 5 +Conjugated hyperbilirubinemia 0.4753234903377215 0.4202311918186844 0.674316570414305 1.0 1.0 4 Q9Y5L0 1 +Urinary tract neoplasm 0.3230573874058288 0.418162858049432 0.6758280496057505 1.0 1.0 41 Q92733,P25054,P54277,Q99496,Q9UPY3,P52701,P21359,P49815,P31749,O60333 10 +Prominent forehead 0.3288423464573173 0.4150129003115049 0.6781324594512688 1.0 1.0 73 Q15813,Q15392,Q14739,P23786,Q6PGP7,P42858,Q92643,A1X283,Q12873,Q93074,P19022,Q12948,P78527,Q7LGA3,P42345,Q9Y4A5 16 +Portal fibrosis 0.4736842105263286 0.4148329767942214 0.6782641770174842 1.0 1.0 4 P06737,P55263,Q9H3U1 3 +Polydactyly 0.3340496189124432 0.4147198969272317 0.6783469650285654 1.0 1.0 39 P17612,Q14739,Q15067,P61978,Q13045,Q9UBM7,O43924,Q9NQ48 8 +Emotional lability 0.2919532365596323 0.4146952483915247 0.6783650112253348 1.0 1.0 56 P17612,Q8N0X7,Q12824,Q7KZN9,Q92804,P28331,P35637,O75306,Q93074,Q9BSH4,P31749 11 +Abnormal macroscopic urine appearance 0.3918207494780599 0.412187183680107 0.680202230261522 1.0 1.0 20 P23786,Q8NFH4,Q9P2R3,Q12769,P53004,O43707,P06132,Q92621,P49815,Q9NQW6 10 +Abnormality of earlobe 0.3830658734108075 0.4105573499554211 0.681397142789872 1.0 1.0 26 O14802,Q15392,P53992,Q8TC12,P52788,Q7LGA3 6 +Paraplegia paraparesis 0.321691386953931 0.4093317372752426 0.6822962276967222 1.0 1.0 70 Q15813,Q8N0X7,O95831,Q7KZN9,P07942,Q6DKK2,P28331,P35637,O75306,Q15526,P18074,Q9BSH4,P19447,Q6W2J9,Q9Y3Z3,P21359 16 +Antenatal onset 0.3846183399711292 0.4077747798124587 0.6834390309671872 1.0 1.0 10 P27635,Q99496,P82650,Q9NSD9 4 +Melanocytic nevus 0.390125084915065 0.4043794846621299 0.6859336839177672 1.0 1.0 15 P18074,P22681,P31749 3 +Limb girdle muscular dystrophy 0.3960648818706123 0.3993928905560534 0.689603731611556 1.0 1.0 8 O14979,Q13642 2 +Mitochondrial inheritance 0.4677736829983017 0.3956023268499616 0.6923984202808473 1.0 1.0 4 P03886 1 +Restrictive ventilatory defect 0.3863243011786618 0.3955060902667414 0.6924694278620904 1.0 1.0 13 Q14331,Q9H9S5,Q05655,P49815,Q7Z392 5 +Polyhydramnios 0.2793074859700486 0.3951638787948495 0.6927219484175282 1.0 1.0 47 Q14739,Q6PGP7,Q96ST3,P37287,P22681,P43034,Q9BV10,P53992,Q9UBM7,O75844,P36776 11 +Hypoparathyroidism 0.3859585878632811 0.3939168276580912 0.6936424461157968 1.0 1.0 13 Q15813,P03886 2 +Abnormality of the tarsal bones 0.3796267880755599 0.3935000642079719 0.6939501765745746 1.0 1.0 26 Q14739,Q7RTS9,P18074,Q9UPT5,O75844 5 +Inverted nipples 0.4098972295915833 0.392826025156928 0.6944479814032749 1.0 1.0 7 Q15067,P61978 2 +Abnormal number of granulocyte precursors 0.7491781722550956 0.3897121708868888 0.6967493956541855 1.0 1.0 2 O75533 1 +Bruxism 0.4090312780867028 0.3895152213693502 0.6968950529639923 1.0 1.0 7 P61978 1 +Gastrointestinal hemorrhage 0.3612396742299061 0.3874708278162521 0.6984076775506509 1.0 1.0 32 Q14739,P22681,Q9NZ08,P54277,P49815,Q02241 6 +Cardiac conduction abnormality 0.3646503493113351 0.3870355280627795 0.6987299060795689 1.0 1.0 31 P23786,O43772,O75306,P19022,Q8N335,P03886,P14923 7 +Central scotoma 0.3775089057609899 0.3860469517581403 0.6994618964652988 1.0 1.0 9 P03886 1 +Telecanthus 0.3396290895091299 0.3854944904548305 0.699871087655114 1.0 1.0 37 Q86UE8,P53992,P19022,Q12948,P13804,Q96EK5,P10412,O75844 8 +Aplasia hypoplasia of the spleen 0.4438960184271317 0.3853355356878757 0.6999888367395639 1.0 1.0 5 O15078,P08865,Q7L590,Q86Y56 4 +Developmental glaucoma 0.3702859234230818 0.3840344375748695 0.7009529234189942 1.0 1.0 29 P61313,A1X283,Q9H9S5,Q12948,Q9Y3Z3,P46783,P31749 7 +Ascending tubular aorta aneurysm 0.4229249495915924 0.3836043067299702 0.7012717474865962 1.0 1.0 6 Q93074 1 +Short philtrum 0.3096894414274997 0.3835947752907737 0.7012788130309826 1.0 1.0 66 O14802,P34897,Q92890,Q96J02,P17612,A1X283,Q9BV10,P57081,Q93074,P52788,Q4G0J3,P25054,P55795,P60953,Q96EK5,Q15233,Q9Y4A5,Q13045,P53992,P19022,O60828,Q99496,Q10471 23 +Headache 0.3202943596356628 0.3829878279034689 0.7017287892046808 1.0 1.0 71 Q9NQZ5,P23786,Q8NFH4,Q12824,P37287,Q05655,Q9NZ08,P54277,Q92621,Q9Y3Z3,Q02241,P21359,P52701,P03886,P31749,O60333 16 +Curly hair 0.3817035936975976 0.3811162457593506 0.7031169931456316 1.0 1.0 12 P55795,P14923,P42345 3 +Congenital ichthyosiform erythroderma 0.4423738681123468 0.3801811841999973 0.7038109253448595 1.0 1.0 5 P18074 1 +Epiretinal membrane 0.5434287819373139 0.3763394658876712 0.7066645426727107 1.0 1.0 3 P25054 1 +Thin bony cortex 0.7429322813938233 0.3745355560713397 0.7080059084048247 1.0 1.0 2 P31749 1 +Neoplasm of the endocrine system 0.3040885693866261 0.3743267110997642 0.7081612616496511 1.0 1.0 43 Q12824,P48735,P25054,Q05655,O14497,P54277,O75874,Q9UPY3,P52701,P21359,P49815,P31749,O60333 13 +Delayed closure of the anterior fontanelle 0.3817837582691423 0.371381258170363 0.7103535828481933 1.0 1.0 14 Q15813,O14802,Q93074,Q9Y487,P40855 5 +Abnormal choroid morphology 0.3785057272604 0.3704200240789072 0.7110695561957545 1.0 1.0 24 Q9H9S5,Q6W2J9,P21359,P49815,P31749,P40855 6 +Conspicuously happy disposition 0.5409470329774682 0.3694911266033148 0.7117616859368798 1.0 1.0 3 P55795 1 +Cerebral hemorrhage 0.3824485122263018 0.3682824085439372 0.712662668129171 1.0 1.0 16 P21359,P23786,P31749,Q12824 4 +Horizontal nystagmus 0.3814644036328739 0.3677986490925668 0.7130233763955931 1.0 1.0 21 O95831 1 +Dermal atrophy 0.3719739730453354 0.3667918031263621 0.713774322314616 1.0 1.0 27 P17612,Q15392,Q9NWM8,P18074,P19447,O75844 6 +Abnormal pulmonary valve morphology 0.380628483417153 0.3664299676521839 0.7140442614446554 1.0 1.0 14 O14802,P22681,P53992,Q92890,O00571 5 +Distal amyotrophy 0.2743843647277331 0.3639573165539322 0.7158898830286335 1.0 1.0 51 Q15813,Q8N0X7,O15270,Q6DD88,P35637,Q99720,Q15120,P39210,Q9BUK6 9 +Areflexia 0.3214987994337024 0.3609469375818261 0.7181391143487539 1.0 1.0 73 Q15067,P61978,O95831,Q13217,P41440,Q15046,Q9H9S5,Q15526,Q9Y5P6,Q9H553,Q15120,P18887,Q16637,P39210,O60333 15 +Seborrheic dermatitis 0.371429679517851 0.360633460640129 0.7183734723031263 1.0 1.0 9 P37287,Q92890,P53992 3 +Abnormality of femur morphology 0.3087173032291874 0.3606032666867795 0.7183960469516371 1.0 1.0 67 Q14739,O14802,O95831,Q7RTS9,Q99575,Q32P28,O75844,Q7LGA3 8 +Abnormal basal ganglia mri signal intensity 0.3725099443564217 0.35894522775428 0.7196360642517159 1.0 1.0 26 Q7KZN9,P28331,O75306,Q15526,Q9BSH4,Q4G0N4,P03886 7 +Intracranial hemorrhage 0.3678289151596473 0.3582948415456339 0.7201226780667835 1.0 1.0 28 P23786,Q12824,P05165,P21359,O75844,P31749 6 +Progressive night blindness 0.3789974095416934 0.3559179499877858 0.7219020127463844 1.0 1.0 15 Q15555,P50213,Q92620 3 +Sparse eyelashes 0.3787011097262615 0.3524381371553964 0.7245097050917468 1.0 1.0 20 P21359,P15924,O75844,Q14574 4 +Papilledema 0.3789531623546293 0.3518305841751278 0.7249653203455173 1.0 1.0 19 Q12824,P25054,P42858,Q7LGA3,P31749 5 +Agenesis of corpus callosum 0.3389568875613358 0.3516734046583448 0.7250832080465084 1.0 1.0 82 P23786,Q15392,O14802,P61978,Q12824,P78318,Q9H9S5,P03886,P57081,Q9Y5P6,Q93074,O14497,P18074,P19022,P19447,P82663,Q7LGA3 17 +Contractures of the joints of the lower limbs 0.2771294049731732 0.3513284648076567 0.7253419424963261 1.0 1.0 53 P23786,P27635,Q5JTV8,P15924,Q9H9S5,P35637,P37268,Q99720,Q13642,Q9Y5P6,P40763,Q9H553,Q6W2J9,Q7LGA3,P14923,Q8IWS0 16 +Abnormal conjunctiva morphology 0.3607746355045822 0.3506951545998237 0.7258170610451176 1.0 1.0 30 Q14739,P28070,P34897,Q9NZ08,P18074,P06132,P50747,P31749 8 +Type ii diabetes mellitus 0.3464745260669664 0.3491310492375939 0.7269909275149751 1.0 1.0 34 O14802,P50213,P31751,Q15555,P03886 5 +Thickened calvaria 0.3682992874254048 0.3477535802629706 0.7280252538113223 1.0 1.0 9 Q7RTS9 1 +Abnormal circulating pyruvate family amino acid concentration 0.3774783323797371 0.3468784252841467 0.7286826556155597 1.0 1.0 16 P11498,P03886 2 +Hyperextensibility of the knee 0.7304404996712666 0.345091825779492 0.7300253385092235 1.0 1.0 2 A1X283 1 +Genu recurvatum 0.7304404996712666 0.345091825779492 0.7300253385092235 1.0 1.0 2 A1X283 1 +Ovarian neoplasm 0.3740831357454534 0.3434974341325824 0.7312242708068684 1.0 1.0 23 P48735,Q01844,P54277,O75874,P52701,P31749 6 +Retinal atrophy 0.3692198773606747 0.3433260224996107 0.7313532061048984 1.0 1.0 26 P42858,P50213,Q92620,Q8TC12,Q7LGA3,Q9NQ48 6 +Infantile spasms 0.3620899682590987 0.3430022717728961 0.7315967510939085 1.0 1.0 29 O60231,P37287,P43034,P19022,Q9H553,Q8NB90,P49815,Q9UBX3,P03886,P36776 10 +Abnormal upper motor neuron morphology 0.3691348438745395 0.3426784879617811 0.7318403480216613 1.0 1.0 10 O14802,P35637 2 +Hypoplasia of the iris 0.3667763517244449 0.341540032901704 0.7326970727287894 1.0 1.0 9 Q12948 1 +Spastic paraparesis 0.3760097843164418 0.3405550692929817 0.7334385589585439 1.0 1.0 20 Q15813,Q8N0X7,Q6DKK2,Q6W2J9,Q9Y3Z3 5 +Basal ganglia cysts 0.4104196844660925 0.3394487957443193 0.7342716645780221 1.0 1.0 6 P23786,P36776 2 +Severe infection 0.3954451841283484 0.3388252561209093 0.7347413738743616 1.0 1.0 7 Q05655,P17812 2 +Carcinoma 0.4100408032082657 0.3381421111684452 0.7352560974932354 1.0 1.0 6 Q07864 1 +Hypoplasia of the brainstem 0.355131994729006 0.337930930008914 0.7354152384996753 1.0 1.0 31 Q7Z460,P98155,O60508,P07942,Q93008,P43034,Q9H9S5,Q9Y5P6,Q9UPT5,Q96EK5 10 +Abnormal pericardium morphology 0.3678101456368471 0.33727195089197 0.7359119021862257 1.0 1.0 10 Q9NZ08 1 +Short chin 0.3695085280820357 0.3366817769079355 0.7363568020860785 1.0 1.0 11 O75844,P42345,Q93074 3 +Renal cortical cysts 0.4095093756089124 0.3363125147313955 0.7366352136250409 1.0 1.0 6 Q6PGP7,P13804 2 +Medial flaring of the eyebrow 0.448677817621353 0.3361190924590643 0.7367810614598782 1.0 1.0 4 Q9NQ48 1 +Pulmonary fibrosis 0.3753384542785181 0.3360596453599636 0.7368258887649339 1.0 1.0 19 Q9UJW0,P15924,Q05655,P21266,P14174,Q9NPE3,P82650 7 +Venous insufficiency 0.3946544768513074 0.3359508829468122 0.7369079056126018 1.0 1.0 7 P53992,Q92890 2 +Progressive encephalopathy 0.5284343426905848 0.3358776753667883 0.7369631125384419 1.0 1.0 3 Q4G0N4 1 +Neoplasm of head and neck 0.3652323078474662 0.3352761494025892 0.7374167836003271 1.0 1.0 9 P25054 1 +Shallow orbits 0.3647874809550746 0.3334783327287166 0.738773242328987 1.0 1.0 9 P61978 1 +Abnormal gastrointestinal motility 0.365004237698274 0.3333003082059832 0.7389076067590308 1.0 1.0 27 P61978,P35637,Q01844,P03886,Q9UBM7 5 +Abnormality of the inner ear 0.3679928881249431 0.330501805714598 0.741020828450035 1.0 1.0 11 P22681,Q15046 2 +Allergy 0.4070185404361673 0.3277871233860888 0.7430726239731793 1.0 1.0 6 P42345 1 +Stomatocytosis 0.722550953320183 0.3271410285142092 0.7435612212692642 1.0 1.0 2 P11171 1 +Generalized myoclonic atonic seizure 0.7225509533201773 0.3271410285141959 0.7435612212692742 1.0 1.0 2 Q96CW1 1 +Eeg with focal spike waves 0.7225509533201773 0.3271410285141959 0.7435612212692742 1.0 1.0 2 Q96CW1 1 +Hypopituitarism 0.3422759451768072 0.3268502093030429 0.7437811816369959 1.0 1.0 34 Q15813,O14802,Q07864,Q12824,Q96ST3,P57081,Q99496,Q4J6C6,P31749,Q7Z392 10 +Abnormal eyelid physiology 0.3916919654682733 0.3252592248539618 0.7449848883084431 1.0 1.0 7 Q9NQZ5 1 +Abnormal natural killer cell morphology 0.4255131914633163 0.3249461002530383 0.7452218655170855 1.0 1.0 5 Q13546,O95394,P33991 3 +Reduced natural killer cell count 0.4255131914633163 0.3249461002530383 0.7452218655170855 1.0 1.0 5 Q13546,O95394,P33991 3 +Abnormality of peripheral nerves 0.296379884869707 0.3237909298201178 0.7460963235503235 1.0 1.0 43 P39210,O95831 2 +Lack of skin elasticity 0.370440548715563 0.3236888011784915 0.7461736501578653 1.0 1.0 14 P17612,Q9H4L7 2 +Varicose veins 0.4058049779726572 0.3236636489716065 0.7461926945206239 1.0 1.0 6 P53992,Q92890 2 +Upper limb muscle weakness 0.3666233259124924 0.3228184288820764 0.7468327553965732 1.0 1.0 25 Q8N0X7,Q12824,Q13642,Q9Y5P6,P31749 5 +Abnormality of metacarpophalangeal joint 0.4423123224885218 0.3172502135939791 0.7510537512817033 1.0 1.0 4 O60828 1 +Broad nasal tip 0.2790176922049787 0.3170601168217186 0.7511979869023377 1.0 1.0 56 P61978,O95831,Q12824,Q86UE8,Q93074,O14497,Q6W2J9,Q2TAL8,Q9Y487,Q7LGA3,O43924 11 +Abnormal hypothalamus physiology 0.3887581827822167 0.3147941499374497 0.7529179537676449 1.0 1.0 7 P31749,Q12824 2 +Dermal translucency 0.3598508560146947 0.3137337370668416 0.7537232750480425 1.0 1.0 9 O14802,O75844 2 +Dry skin 0.3532609139753317 0.3136493144659005 0.753787400580689 1.0 1.0 30 Q6PGP7,Q06136,P37268,P11802,P18074,P19447,Q9Y3Z3,Q9H4L7 8 +Cough 0.3607642746617222 0.3134635974099855 0.7539284731073024 1.0 1.0 27 P41440,O15270,P15924,Q6DD88,P40763,P53621,Q6W2J9,P49815 8 +Hepatic necrosis 0.373470668207842 0.3113149030378908 0.7555612388324153 1.0 1.0 8 P13804 1 +Narrow mouth 0.3139829787598864 0.3084369488885519 0.7577498703431047 1.0 1.0 73 O14802,Q15392,P42858,Q9Y487,Q7LGA3,P37287,P43034,Q15046,Q93074,P52788,P27635,Q6PGP7,Q86UE8,P25054,O75844,P31749,Q15233,Q96ST3,P53992,O60828,Q15555 21 +Autoimmunity 0.3346402332193258 0.3078675164248516 0.7581831441700748 1.0 1.0 35 P29144,P49327,Q06787,Q9Y5L0,P40763,P42224,Q05655,P53621,P53992,Q92890,Q9UJV9,Q13546,Q9Y3Z3,P14174,P21964,Q96J02,Q92888,O95394 18 +Abnormal pupil morphology 0.3637293984195103 0.3067806579631572 0.7590103315308501 1.0 1.0 12 Q12948,Q96ST3,P61586 3 +Lower limb asymmetry 0.3858881273533286 0.3046773976219396 0.7606118657315599 1.0 1.0 7 Q15555 1 +Abnormality of the ovary 0.2815436060142383 0.3042830532460837 0.7609122549761349 1.0 1.0 58 P48735,Q05655,Q01844,P31751,P54277,O75874,Q9UPY3,P52701,Q9H1A4,O75844,P31749,P82650,Q9NQ48 13 +Abnormally large globe 0.3857604827827597 0.3042302797444201 0.7609524575809532 1.0 1.0 7 A1X283,P31749 2 +Persistence of primary teeth 0.3714437274896861 0.3037759348894144 0.7612986020391417 1.0 1.0 8 O75844,P61586,Q6W2J9 3 +Abnormal arterial physiology 0.3606497335985577 0.3037614600571447 0.7613096305340807 1.0 1.0 26 Q9Y3Z3,Q14739,O75844,Q9NZ08 4 +Posterior fossa cyst 0.7110453648915145 0.3018902205490311 0.7627357510332011 1.0 1.0 2 Q9H9S5 1 +Branchial cyst 0.711045364891513 0.3018902205490285 0.7627357510332031 1.0 1.0 2 P27635 1 +Widened subarachnoid space 0.3507735507377796 0.3017051185477943 0.7628768659767222 1.0 1.0 30 O43776,O95831,Q9BV10,Q93074,Q01105,P03886 6 +Abnormality of body mass index 0.5149041062067059 0.3013286021977472 0.7631639324795703 1.0 1.0 3 P42858 1 +Abnormal sarcomere morphology 0.7100591715976313 0.2997781248535344 0.7643464022082163 1.0 1.0 2 P51114 1 +Abnormal z disc morphology 0.7100591715976313 0.2997781248535344 0.7643464022082163 1.0 1.0 2 P51114 1 +Renal hypoplasia aplasia 0.3311438023584199 0.298779410736626 0.7651083616189582 1.0 1.0 82 Q15392,P61313,Q15526,Q7LGA3,P30153,P46783,P21359,O43924,Q6PGP7,P25054,O75306,P57678,Q6W2J9,P35606,Q9UBM7,Q9Y4A5,Q13045,P53992,O60828,P08708 20 +Renal salt wasting 0.7094017094017151 0.2983747023335881 0.7654171948195012 1.0 1.0 2 Q9NP81 1 +Abnormality of the leydig cells 0.7094017094017072 0.2983747023335718 0.7654171948195136 1.0 1.0 2 P52788 1 +Severe varicella zoster infection 0.5134222443179555 0.2976628478911424 0.7659605017928799 1.0 1.0 3 P17812 1 +Squamous cell carcinoma of the skin 0.397957441887772 0.2974897043153714 0.7660926671698465 1.0 1.0 6 P18074,Q9H4L7 2 +Hypoplasia of teeth 0.3652465297363524 0.2965494819874567 0.7668104841690271 1.0 1.0 21 P61586,P18074,P19447,P21359,O75844,P36776 6 +Hypocalcemia 0.3646198218641317 0.2963013660219483 0.7669999428330165 1.0 1.0 15 Q15813,Q9BV10,P53992,Q92890,P21964,Q4J6C6 6 +Abnormal circulating aspartate family amino acid concentration 0.3693645518806873 0.2961094363099667 0.7671465078376516 1.0 1.0 8 Q4G0N4 1 +Amaurosis fugax 0.355124869619987 0.2951989050213732 0.7678419384113804 1.0 1.0 9 P54277 1 +Retinal thinning 0.7077580539118963 0.2948824386317069 0.768083687698788 1.0 1.0 2 P51648 1 +Reduced antigen specific t cell proliferation 0.7067718606180177 0.2927982850941911 0.7696763391368286 1.0 1.0 2 P17812 1 +Abnormal t cell proliferation 0.7067718606180177 0.2927982850941911 0.7696763391368286 1.0 1.0 2 P17812 1 +Recurrent staphylococcal infections 0.7067718606180097 0.2927982850941745 0.7696763391368413 1.0 1.0 2 P40763 1 +Recurrent staphylococcus aureus infections 0.7067718606180097 0.2927982850941745 0.7696763391368413 1.0 1.0 2 P40763 1 +Abnormal pancreas size 0.3823823501665956 0.2924858986747727 0.7699151399751127 1.0 1.0 7 P40763 1 +Elliptocytosis 0.5110535581217128 0.291852888820716 0.770399105243212 1.0 1.0 3 P11171 1 +Exodeviation 0.3637107837363152 0.2900751959962889 0.7717587111010653 1.0 1.0 21 P27635,Q15233,Q10471,P55795,P60953,Q8NB90,Q6W2J9,Q99496,Q7Z392 9 +Capillary malformation 0.3608383228806225 0.2897156418187716 0.7720337888644642 1.0 1.0 13 P21359 1 +Fatigable weakness of bulbar muscles 0.3640318325722454 0.2892195156040172 0.7724133984271813 1.0 1.0 17 Q9Y5P6,Q92804 2 +Abnormality on pulmonary function testing 0.3623161821258285 0.2872907008716639 0.7738897423180848 1.0 1.0 22 Q12824,Q14331,Q9H9S5,Q05655,P53621,P49815,Q96J02,P31749,Q7Z392 9 +Finger syndactyly 0.3220840539743623 0.2871454861664678 0.774000925030145 1.0 1.0 37 P15924,Q93074,Q9UBM7,Q6W2J9,Q96EK5,P14923,Q9NQ48 7 +Recurrent fractures 0.3379590059953434 0.2859970405336669 0.7748803882429114 1.0 1.0 33 Q13126,Q32P28,P48735 3 +Aortic aneurysm 0.2593616443817776 0.2855822530515793 0.7751980976266695 1.0 1.0 49 P61978,Q96PU5,Q93074,Q9Y3Z3,P49815,O75844,Q7LGA3 7 +Abnormality of hair pigmentation 0.3608437557152375 0.2851568703439338 0.7755239615885283 1.0 1.0 23 Q13126 1 +Abnormality of the anterior fontanelle 0.337637489222508 0.2844187541103169 0.7760894885025962 1.0 1.0 33 Q15813,O14802,Q93074,Q32P28,P13804,P42345,Q9Y487,P40855 8 +Rimmed vacuoles 0.3605498093474426 0.2838858287398945 0.7764978769385948 1.0 1.0 14 Q9Y5L0,Q86U42,Q13642,P22626,O14979 5 +Mildly elevated creatine kinase 0.3603542783901177 0.2830725726923619 0.7771212058922732 1.0 1.0 23 Q16836,Q9H553,P39210,Q9BUK6,Q2TAL8 5 +Absent facial hair 0.3533467981808476 0.2800820874677555 0.7794145270739596 1.0 1.0 10 P15924,O75844 2 +Adrenal hypoplasia 0.3783278801004367 0.2786198414255755 0.7805365842033021 1.0 1.0 7 O75844 1 +Thin eyebrow 0.3598536975087962 0.2773554054469508 0.7815072201400026 1.0 1.0 15 P15924,O14802,P21359,P14923 4 +Periorbital fullness 0.3599418722102989 0.2773118778266066 0.7815406399006082 1.0 1.0 22 P62266,P57081,Q93074,Q7LGA3,P40855 5 +Receptive language delay 0.3588623345637897 0.2772720508886759 0.781571218694123 1.0 1.0 14 Q7LGA3,Q8NB90 2 +Excessive daytime somnolence 0.3607151014526547 0.2759045965150595 0.7826213433898368 1.0 1.0 17 Q12824,P42858,P26358,P31749,Q9UBM7 5 +Polyphagia 0.3774574903579686 0.2756764583046448 0.7827965787646534 1.0 1.0 7 Q4J6C6 1 +Abnormality of hair texture 0.268587999228716 0.2742374698378625 0.7839021346970352 1.0 1.0 54 Q6PGP7,P15924,P22681,P62266,O75844,Q93074,P55795,P18074,O60828,P19447,Q9Y487,P14923,P42345 13 +Abnormal rib cage morphology 0.320711026165502 0.2710168315585302 0.7863780868466348 1.0 1.0 79 P17612,Q15813,Q14739,O14802,O95831,Q7RTS9,Q99575,P22681,Q93074,Q32P28,Q6W2J9,O75844,Q9UBM7 13 +Abnormal metabolic brain imaging by mrs 0.3593000547360141 0.2692191820637535 0.7877610198783724 1.0 1.0 18 O14802,Q15046,P03886,O75306 4 +Scotoma 0.353331165504447 0.266242924722422 0.790052126477029 1.0 1.0 12 P03886 1 +Lumbar scoliosis 0.4237642913307429 0.2652379079079453 0.7908261940512591 1.0 1.0 4 P36776 1 +Burkitt lymphoma 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Follicular hyperplasia 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Coombs positive hemolytic anemia 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Abnormal proportion of double negative alpha beta regulatory t cell 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Increased b cell count 0.6932938856015738 0.2651684994249405 0.7908796603417532 1.0 1.0 2 Q05655 1 +Smooth muscle antibody positivity 0.69329388560157 0.2651684994249336 0.7908796603417585 1.0 1.0 2 Q96J02 1 +Slender build 0.3542246658272474 0.2640751205309278 0.7917220345413307 1.0 1.0 13 P17612,O14802,Q93074 3 +Toe syndactyly 0.279813981776778 0.2632320967918142 0.7923716932263487 1.0 1.0 60 O14802,P34897,Q96PU5,P37268,Q93074,Q6W2J9,O43924,Q9UBM7,Q9H4L7 9 +Abnormality of the wrist 0.3390846170843017 0.2605426330693063 0.7944452340416464 1.0 1.0 31 O95831 1 +Muscle fiber atrophy 0.3570722946745664 0.2601985819322899 0.7947105980544338 1.0 1.0 19 P23786,P61978,Q9NP81,P35637,Q99720,Q13642,P22626 7 +Microdontia 0.3439679910642294 0.258142504850554 0.7962969287898278 1.0 1.0 29 P37287,Q15555,P61586,P57081,Q12948,Q9H1A4,Q9Y487,Q7LGA3 8 +Acute phase response 0.3459742877699059 0.2566804317284319 0.797425478772332 1.0 1.0 28 P28070,P41440 2 +Low hanging columella 0.3471266577180529 0.256590855443051 0.7974946350151311 1.0 1.0 10 P55795,O60828 2 +Abnormality of the vasculature of the eye 0.3122617884387703 0.2565264570407802 0.7975443539726055 1.0 1.0 76 Q14739,P28070,Q14331,P34897,P50213,Q9NZ08,Q12948,P21359,P50747,Q15555,P03886 11 +Prematurely aged appearance 0.3018875249316283 0.2564505393623548 0.7976029674726881 1.0 1.0 40 O14802,Q13126,O75844,Q93074,P18074,P19447,Q9Y487 7 +Abnormality of the septum pellucidum 0.3018512204179107 0.2562531941637634 0.7977553364373324 1.0 1.0 40 Q15392,P37287,P43034,Q9H9S5,Q9BV10,Q96F86,Q9NZ01,Q9NUQ7 8 +Micropenis 0.2829175657895797 0.2557373972239767 0.7981536163283041 1.0 1.0 62 Q15813,Q07864,Q8IWS0,Q9H9S5,Q9BV10,Q9Y5P6,P18074,P19022,Q9Y3Z3,P78527,Q9UBM7,Q9NQ48 12 +Focal emotional seizure 0.3444615211584509 0.2547768380135268 0.7988954656404053 1.0 1.0 9 P67870,Q00610,Q01105,Q08209 4 +Focal non motor seizure 0.3444615211584509 0.2547768380135268 0.7988954656404053 1.0 1.0 9 P67870,Q00610,Q01105,Q08209 4 +Ectrodactyly 0.3529077373080012 0.2543661335230078 0.7992127122040433 1.0 1.0 14 Q9UBM7,Q93074 2 +Cortical dysplasia 0.3453107569412991 0.2537867821383469 0.7996602855323935 1.0 1.0 28 Q96ST3,Q96PU5,Q96F86,O00571,Q9NZ01,P49815,Q9NUQ7,P42345 8 +Absent hair 0.348017295334006 0.2526705883483495 0.800522777632938 1.0 1.0 11 P15924,O75844 2 +Nail dystrophy 0.3464030812560957 0.2495361107854959 0.8029461117621317 1.0 1.0 27 P15924,O75844,P18074,O60828,P19447,Q9H1A4,Q9NPE3,P14923,Q9H4L7 9 +Abnormal caudate nucleus morphology 0.3444872386158755 0.2468361931636589 0.8050349988732328 1.0 1.0 10 Q15526,O75306,Q9BU61,P42858 4 +Gastrointestinal obstruction 0.3520262340979067 0.2442020859230876 0.8070743116320975 1.0 1.0 16 P18074,Q15813,Q01844 3 +Persistent ebv viremia 0.4904996014694244 0.2440744073414936 0.8071731932078463 1.0 1.0 3 Q05655 1 +Submucous cleft soft palate 0.490306673102465 0.2436489045661954 0.8075027490638604 1.0 1.0 3 O14802 1 +Periorbital edema 0.3483980085960846 0.2436171917528966 0.8075273123015039 1.0 1.0 25 P28070,Q14331 2 +Memory impairment 0.2994916793401941 0.2435504543885834 0.8075790045112585 1.0 1.0 40 Q12824,P26358,Q9NZ08,P54277,P21359,P03886,P31749 7 +Emg decremental response of compound muscle action potential to repetitive nerve stimulation 0.3980711320876976 0.2430953550502616 0.8079315294409777 1.0 1.0 5 Q9Y5P6 1 +Response to drugs acting on neuromuscular transmission 0.3980711320876976 0.2430953550502616 0.8079315294409777 1.0 1.0 5 Q9Y5P6 1 +Abnormal adipose tissue morphology 0.2765859754203459 0.2421967845545084 0.8086276864486459 1.0 1.0 60 P17612,P27635,O14802,P28070,P15924,Q05655,Q9BV10,O75844,Q13642,P18074,P31751,P19447,Q9Y3Z3,Q9BUK6,Q9Y487,P31749 16 +Pulmonary artery dilatation 0.3451723131028292 0.2421705693520217 0.8086479986482389 1.0 1.0 11 Q7LGA3 1 +Progressive spastic paraplegia 0.3490657921669001 0.2365409334964787 0.8130129479537556 1.0 1.0 23 Q7KZN9,P28331,O75306,Q15526,Q9BSH4,Q96CU9 6 +Vascular dilatation 0.2839121036332891 0.2351542268906254 0.8140890315158202 1.0 1.0 64 P61978,Q96PU5,P49815,Q93074,Q9Y5P6,P21359,Q7LGA3 7 +Impaired tandem gait 0.3477338218617163 0.2350279519956536 0.8141870382285112 1.0 1.0 14 O75787,Q7LGA3,P42858 3 +Aortic valve stenosis 0.3389628558820201 0.2347332723795361 0.8144157615138772 1.0 1.0 9 P22681,O75844 2 +Open mouth 0.3360391191921488 0.2344565195949393 0.8146305848279036 1.0 1.0 30 P67870,P04350,P61978,P30153,Q96ST3,P62266,Q93074,Q13045,P42345,P31749,Q15233 11 +Erythema 0.3498493932245736 0.2339671747621546 0.8150104621878769 1.0 1.0 21 Q06136,P15924,P40763,P18074,P19447,Q9H1A4,P03886 7 +Genu valgum 0.3268881889165647 0.2335279588810224 0.8153514615906989 1.0 1.0 33 P17612,Q8N0X7,Q7RTS9,P21359,Q7LGA3 5 +Waddling gait 0.3402595106449879 0.2321560962554548 0.8164167763087797 1.0 1.0 28 Q7RTS9,Q9H9S5,Q13642,Q9Y5P6,Q9H553,P22626,Q9NUQ7,Q4J6C6 8 +Delayed cranial suture closure 0.3327538815744635 0.2320619181235103 0.8164899224490194 1.0 1.0 31 Q15813,O14802,A1X283,O75844,Q93074,Q32P28,Q9Y487,P40855 8 +Chorioretinal coloboma 0.3635811663123792 0.2304072825558411 0.8177753027170007 1.0 1.0 7 Q6W2J9 1 +Alopecia 0.3017960739035329 0.2298907772677535 0.8181766430891648 1.0 1.0 39 P17612,Q06136,P15924,Q05655,P61586,P18074,P06132,P19447,Q9H1A4,P50747,O75844,P14923 12 +Prominent nasal bridge 0.2532475863989365 0.2294586742743929 0.8185124369191985 1.0 1.0 50 Q96EK5,Q86UE8,P78318,Q9BV10,Q93074,P53992,Q6W2J9,O43924,P52788,Q9NQ48,Q9Y4A5 11 +Axial dystonia 0.4837145698317605 0.2293734337336835 0.8185786825779697 1.0 1.0 3 P35637 1 +Proximal femoral metaphyseal irregularity 0.4833936205195558 0.2286915474059839 0.8191086649030865 1.0 1.0 3 Q9Y3A5,Q5F1R6 2 +Exercise induced muscle cramps 0.3928140934811175 0.2286623845927996 0.819131332953142 1.0 1.0 5 P23786 1 +Decreased circulating cortisol level 0.3387834714673352 0.2262067363750126 0.8210406315267631 1.0 1.0 10 P31749,Q12824 2 +Autoimmune hemolytic anemia 0.336467089230029 0.2258239683726068 0.8213383344953202 1.0 1.0 9 P40763,Q05655,P29144 3 +Aplasia hypoplasia of the humerus 0.3385544804035365 0.2253916357291175 0.8216746179770269 1.0 1.0 10 O14802,Q9BV10 2 +Macular atrophy 0.3615970857495698 0.2241980605339552 0.8226031925348842 1.0 1.0 7 Q9NQ48 1 +Abnormality of globe size 0.2758176455812494 0.2240221996119377 0.8227400293982279 1.0 1.0 61 A1X283,Q9H9S5,Q96CW1,Q9Y5P6,P18074,P53992,O60828,P19447,Q6W2J9,Q9BUK6,Q15555,P31749,O43924 13 +Severe global developmental delay 0.2758004201661955 0.2239153496344408 0.8228231716827998 1.0 1.0 61 Q15067,P42858,P07942,Q7RTS9,Q15046,Q9BV10,P03886,P18074,P57678,Q7LGA3,P40855 11 +Skin nodule 0.343364972723286 0.2231864352227279 0.8233904088188326 1.0 1.0 25 Q92990,P48735,P11802,P35637,Q9NZ08,O75874,P49815,P31749,O60333 9 +Nasal speech 0.3174720827317361 0.2229612649443241 0.8235656537466496 1.0 1.0 35 P42858,Q93074,P53992,Q4J6C6,O60828,Q9Y487,Q7LGA3 7 +Abnormal circulating iga level 0.3412786561080662 0.2217813610884127 0.8244840898426131 1.0 1.0 12 Q9Y5L0,Q05655,Q9BV10,Q96J02,O95394,P42345 6 +Inflammatory abnormality of the eye 0.2847121808710455 0.2207975132637877 0.8252500999286603 1.0 1.0 42 Q14739,P50747,P28070,Q9NZ08 4 +Lethargy 0.3022469418161678 0.2203664728765913 0.8255857543838656 1.0 1.0 74 P23786,Q16836,P05165,O43772,P28331,Q96RQ3,O75306,O14678,P46783,P50747,P03886,P11182 12 +Abnormal circulating gonadotropin concentration 0.344736095673654 0.2202099658533038 0.8257076354964743 1.0 1.0 15 Q12824,Q99496,P31749,Q96MF7,P82650 5 +Glomerulonephritis 0.3464940240875087 0.2198049133930404 0.8260230928792014 1.0 1.0 20 Q8NFH4,P49327,Q9P2R3,Q05655,Q12769,O95394,P53621,O43707,Q92621,Q9NQW6,Q96J84 11 +Hyperpigmentation of the skin 0.3283222091291936 0.2189993283173005 0.8266505709929353 1.0 1.0 87 P42858,P22681,P19447,Q7LGA3,Q14739,Q06136,A1X283,Q93074,P06132,Q9H1A4,P21359,P52788,Q9H4L7,Q7Z392,O60333,Q6PGP7,P25054,P18074,O75844,P31749,Q96ST3,P52701,P49815,Q15555,P42345 25 +Prominent metopic ridge 0.338493970402446 0.2181393250003671 0.827320558180304 1.0 1.0 11 P18074,P40763,P61978,P30153 4 +Abnormal oral mucosa morphology 0.2787033015706994 0.2159395273140225 0.8290348855413028 1.0 1.0 63 Q15392,Q14739,Q9NZ08,P49815,Q9UBM7 5 +Incomplete penetrance 0.334105853550714 0.2157282297124942 0.8291995951683606 1.0 1.0 29 Q92733,Q12824,Q06787,P42224,Q9UJV9,O43707,O14979,P52701,P03886,O60333 10 +Abnormal subcutaneous fat tissue distribution 0.3877330970432027 0.2151166795553977 0.8296763499100683 1.0 1.0 5 P31749 1 +Polar cataract 0.4034241241267177 0.2136494177688315 0.8308204592320023 1.0 1.0 4 Q7LGA3 1 +Pulmonic stenosis 0.3352480542267759 0.2114082846021749 0.8325686926579023 1.0 1.0 28 O14802,O75306,Q15526,Q6W2J9,P21359 5 +Abnormality of dental morphology 0.2757437612740267 0.210703847260902 0.8331183723237363 1.0 1.0 62 P17612,P42858,P37287,Q15555,P61586,P57081,Q93074,Q13045,Q12948,Q9UBM7,Q6W2J9,O60828,Q9H1A4,Q9Y487,Q7LGA3,P36776 16 +Adenomatous colonic polyposis 0.3859629885783142 0.2104924212503515 0.833283366134697 1.0 1.0 5 Q07864 1 +Hypoplasia of the frontal lobes 0.3444719003857779 0.2099660388930265 0.8336941792219283 1.0 1.0 8 Q9UBM7 1 +Minimal change glomerulonephritis 0.3416813459548666 0.2092380629774142 0.834262400025046 1.0 1.0 15 Q8NFH4,Q9P2R3,Q12769,O43707,Q92621,Q9NQW6,Q96J84 7 +Arnold chiari type i malformation 0.3688567894358505 0.2084762054534367 0.8348571597704515 1.0 1.0 6 O14802,Q15043 2 +Mitral valve prolapse 0.342361228951042 0.2074623213478492 0.8356488157137827 1.0 1.0 22 P21359,P55795,Q6W2J9,Q93074 4 +Decreased specific anti polysaccharide antibody level 0.4715831131406959 0.2044595866866805 0.8379943700331656 1.0 1.0 3 Q05655 1 +Chronic noninfectious lymphadenopathy 0.4715831131406959 0.2044595866866805 0.8379943700331656 1.0 1.0 3 Q05655 1 +Impaired glucose tolerance 0.3993932905103871 0.2041406817403104 0.838243564219044 1.0 1.0 4 Q96MF7 1 +Limb hypertonia 0.3054497069375543 0.2040446349481553 0.8383186189228236 1.0 1.0 37 Q14739,Q8NB90,P05165 3 +Osteolysis 0.3259751464127322 0.2029501446769412 0.8391739999656715 1.0 1.0 31 P48735,P22681,Q6DD88,P22626,P06132,O75874,P21359,O75844 8 +Basal ganglia gliosis 0.3320140423898985 0.2025503361153592 0.8394865112715952 1.0 1.0 10 Q15526,P36776,O75306,Q9BU61 4 +Prominent nose 0.3416907295459548 0.2019807836398328 0.8399317470040826 1.0 1.0 20 Q8N0X7,Q12873,Q93074,Q13642,Q2TAL8,P40855 6 +Mood swings 0.4702400526142598 0.2018110191900663 0.8400644667266239 1.0 1.0 3 Q8WYQ5,O00232 2 +Sparse or absent eyelashes 0.3343610620541956 0.2001409909589996 0.8413703157079424 1.0 1.0 27 P15924,Q14574,P21359,O75844,P14923 5 +Vitritis 0.6571334648257696 0.1991700711937957 0.8421297101112453 1.0 1.0 2 P04439 1 +Focal impaired awareness seizure 0.3400445899880569 0.19696925340543 0.8438515986414694 1.0 1.0 21 P67870,P43034,Q96CW1,P19022,Q01105,P49815,Q08209,P42345 8 +Abnormal paranasal sinus morphology 0.3398400142243826 0.1962222937437091 0.8444361793538087 1.0 1.0 21 P28070 1 +B lymphocytopenia 0.3520927479220181 0.1954124070293863 0.8450701044373803 1.0 1.0 7 P42224,Q9BV10 2 +Abnormal pulmonary valve physiology 0.3239136587609079 0.1943904994574074 0.8458701283720478 1.0 1.0 31 O14802,P15924,O75306,Q15526,Q6W2J9,P21359 6 +Gonosomal inheritance 0.2871159551177731 0.1920414319919483 0.847709751350304 1.0 1.0 69 P27635,O95831,P37287,P78318,Q93074,Q13642,O14654,P55795,O60828,O00571,Q6W2J9,P46020,O75787,Q15120,P52788,Q8IWS0 16 +2 3 toe cutaneous syndactyly 0.4648609270057798 0.1914244938835981 0.8481930315339354 1.0 1.0 3 Q6W2J9 1 +Decreased activity of the pyruvate dehydrogenase complex 0.3384255515250444 0.190181480932719 0.8491669223567806 1.0 1.0 20 Q7KZN9,P28331,O75306,Q15526,Q9BSH4,Q96CU9 6 +Renal tubular acidosis 0.3348708727653522 0.1893557018285655 0.8498140411411594 1.0 1.0 14 Q15526,P11498,O75306,Q4G0N4 4 +Abnormal protein o linked glycosylation 0.4633423040296874 0.1885565461759146 0.8504403929131841 1.0 1.0 3 Q8N511 1 +Aplasia hypoplasia of the phalanges of the hand 0.2593911433539561 0.1884225325550819 0.8505454376092287 1.0 1.0 56 Q14739,Q12824,Q7RTS9,Q93074,O75844,P42345 6 +Adult onset 0.2739273293087862 0.1876628995592252 0.8511409153500296 1.0 1.0 63 Q9NQZ5,Q07864,P41440,P26358,P31751,O14979,Q16637,P49815,P14923,P42345 10 +Arrhinencephaly 0.3312884157515871 0.1871466019734286 0.8515456904816079 1.0 1.0 12 P53992,Q92890,Q9Y3Z3 3 +J shaped sella turcica 0.3917763157894892 0.1868383263542935 0.851787395923578 1.0 1.0 4 Q96AX1,O60568,O75431 3 +Telangiectasia 0.3055824355507372 0.1863721063789917 0.8521529650749649 1.0 1.0 36 Q14739,Q07864,Q14331,O75306,P18074,P21359,P03886,P31749 8 +Truncal titubation 0.6489151873767243 0.1858674269039168 0.8525487266229308 1.0 1.0 2 Q6PJG6 1 +Childhood onset 0.3091687604846986 0.1856793462372438 0.8526962259655873 1.0 1.0 35 Q15813,Q8N0X7,P29144,Q14331,P40763,P50213,Q9BSH4,Q9NUQ7,Q96J84 9 +Abnormality of circulating enzyme level 0.330195895321971 0.1852852133881453 0.8530053352346534 1.0 1.0 91 O95831,O43772,P22626,P39210,Q16836,P15924,Q07021,Q9H553,Q9BUK6,P23786,Q5JTV8,Q9H9S5,Q9Y5P6,O14979,Q2TAL8,Q14331,Q9NWM8,Q86U42,P46020,Q15120 20 +Abnormal morphology of the limbic system 0.3268847755977636 0.1852466495831253 0.8530355811473351 1.0 1.0 10 P67870,Q00610,Q01105,Q08209 4 +Generalized tonic seizure 0.3354682229931645 0.184459093240984 0.8536533153326484 1.0 1.0 16 P67870,P27635,Q00610,P43034,Q15046,Q01105,Q08209 7 +Recurrent fever 0.3300530305111105 0.1830104116908021 0.8547898492417387 1.0 1.0 12 P28070 1 +Thyroid adenoma 0.3592557103974072 0.1821331184109531 0.8554782586566292 1.0 1.0 6 P31749 1 +Ventricular hypertrophy 0.3039974039534076 0.1794139971611527 0.857612641562719 1.0 1.0 36 P23786,O43772,Q07021,Q9H9S5,Q9BV10,O75787,O75844,P03886,Q96MF7 9 +Recurrent sinusitis 0.3733693342939079 0.1790388693153514 0.8579071814617516 1.0 1.0 5 O14920,Q05655 2 +Optic disc coloboma 0.3579596853931476 0.1786991625526582 0.8581739267864377 1.0 1.0 6 P78318 1 +Osteopenia 0.2887952197270313 0.1783949639042785 0.8584128040917807 1.0 1.0 71 P17612,O14802,Q07864,P61978,Q9NWM8,Q13126,O75844,Q32P28,P18074,P06132,P19447,P57678,P21359,Q9Y487 14 +Thickened cortex of long bones 0.4562015565837564 0.17545298610051 0.8607237093376303 1.0 1.0 3 P21359 1 +Abnormal circulating androgen level 0.3302481569792589 0.1738198264394576 0.8620070623364124 1.0 1.0 14 O14802,Q12824 2 +Neoplasm by histology 0.3569365098716833 0.1735404920055039 0.8622266026764942 1.0 1.0 106 Q15392,P61313,P48735,Q13126,Q01844,O14497,P19447,Q07864,P46783,P21359,O43924,O60333,Q6PGP7,Q12824,Q92804,P11802,P18074,P54277,O75874,P31749,Q05655,P08708,P49815,Q15555 24 +External ear malformation 0.3311730990176098 0.1730641124744479 0.8626010333487033 1.0 1.0 15 Q15813,Q15555,Q6W2J9,P40855 4 +Poor motor coordination 0.3267552350626725 0.1721316036886337 0.8633340674143994 1.0 1.0 12 Q9Y5P6,Q8TC12,P42858 3 +Broad forehead 0.2983132940195488 0.1717781465182375 0.8636119466797496 1.0 1.0 37 O14802,Q6PGP7,O43776,Q07864,P78330,A1X283,P78318,Q13045,P19022,Q9H490,P21359 11 +Agammaglobulinemia 0.6397107166337885 0.1717237347234249 0.8636547253834304 1.0 1.0 2 Q9NRZ9 1 +Abnormality of the musculature of the thigh 0.3316256952324949 0.1699537103442784 0.8650465407387671 1.0 1.0 8 O14979 1 +Elevated hemoglobin a1c 0.6380670611439896 0.169282082604674 0.865574768597797 1.0 1.0 2 Q96MF7 1 +Abnormality of the musculature of the upper arm 0.3429388191650026 0.1692382474778827 0.8656092465351704 1.0 1.0 7 O14979 1 +Proximal upper limb amyotrophy 0.3429388191650026 0.1692382474778827 0.8656092465351704 1.0 1.0 7 O14979 1 +Aplasia hypoplasia of the cerebellar vermis 0.27679440551506 0.1688545161259153 0.8659110762515474 1.0 1.0 66 P23786,O14802,Q8NFH4,Q12824,P07942,P43034,Q9H9S5,O14497,Q9Y5P6,Q12948,Q6W2J9,P78527,Q9H490,Q9Y487,Q9UBM7,O43924,Q9Y4A5 17 +Oligodontia 0.3236490907657009 0.1679886003155624 0.866592247263513 1.0 1.0 11 O14802,P61978,Q6W2J9 3 +Craniofacial osteosclerosis 0.4504860202609524 0.1654203117675698 0.8686131674281987 1.0 1.0 3 Q15813 1 +Generalized muscle weakness 0.3074797779164169 0.1640784568616575 0.8696693808928966 1.0 1.0 34 Q92804,O95831 2 +Celiac disease 0.3808922084407738 0.163651434982297 0.870005551244851 1.0 1.0 4 Q9Y5L0,P40763 2 +Abnormality of immune serum protein physiology 0.340860656597056 0.163514415472822 0.8701134239936412 1.0 1.0 7 Q05655,Q9Y3Z3 2 +Abnormality of pulmonary circulation 0.3185467393144134 0.1631127829555263 0.8704296352457095 1.0 1.0 30 Q9NZ08,Q93074,O14678,P21359,O75844,P03886,P31749 7 +Papule 0.3306230826650462 0.1630563525618168 0.8704740653945977 1.0 1.0 20 P21359,O75844,Q9NZ08 3 +Specific learning disability 0.2736529670299123 0.1629666501359737 0.8705446929297582 1.0 1.0 65 P04350,Q8N0X7,Q96EK5,P42858,P35637,P62266,P49815,P53992,P22626,P21359,Q8TC12,P03886,P42345 13 +Abnormality of malar bones 0.2797598010765449 0.162633071394903 0.8708073464337311 1.0 1.0 68 O14802,Q14739,Q07864,O95831,Q4G0J3,P25054,P37287,P61586,Q93074,P53992,Q12948,O60828,Q9H490,Q8TC12,P21359,Q9Y487,Q96MF7,Q15233 18 +Amblyopia 0.3266562809613016 0.1620814719377629 0.8712416965180985 1.0 1.0 14 Q07021,Q9UHX1,O15294,Q92974,P10412,P07814 6 +Vestibular dysfunction 0.3204374825418196 0.1617877502758574 0.8714729998155755 1.0 1.0 29 P41440,Q9NZ08,Q6W2J9,P21359,P14923,O60333 6 +Lower limb spasticity 0.287656702031199 0.1611776418358024 0.8719534901024752 1.0 1.0 72 Q15813,Q8N0X7,O95831,Q7KZN9,P07942,Q6DKK2,P35637,P28331,Q99720,O75306,Q15526,Q9BSH4,Q6W2J9,Q9Y3Z3 14 +Bilateral sensorineural hearing impairment 0.3275370892090343 0.1595480109409809 0.8732371354599642 1.0 1.0 24 Q15067,Q13217,P35637,P18074,P03886 5 +Progressive proximal muscle weakness 0.631163708086788 0.1593047272737145 0.8734287964968419 1.0 1.0 2 Q7Z392 1 +Episodic pain 0.3242515161676782 0.1588563299393207 0.8737820673592755 1.0 1.0 13 P21359,P23786,O60333 3 +Speech apraxia 0.3281722241178891 0.1587993219081757 0.8738269830711205 1.0 1.0 23 Q8N0X7,P42858,Q12873,O14646,Q7LGA3,Q7Z392 6 +Tremor by anatomical site 0.3281659166303297 0.1587776031604069 0.8738440950305253 1.0 1.0 23 P26358,P35637,Q99720,Q15120,Q16637 5 +Heart block 0.3286133780641993 0.1581830943353784 0.8743125247988912 1.0 1.0 22 P23786,O43772,Q13642,P19022,Q8N335,P14923 6 +Abnormality of the elbow 0.2623023063688772 0.1575383495721115 0.8748205866271344 1.0 1.0 60 P23786,P22681,Q7RTS9,P37268,Q99575,Q93074,P21359,Q7LGA3 8 +Testicular atrophy 0.3638707475899095 0.1570332434372766 0.875218648638771 1.0 1.0 5 P52788 1 +Serositis 0.3283455906963666 0.1554296796498791 0.876482587502819 1.0 1.0 20 Q8NFH4,P49327,Q9P2R3,Q12769,Q9NZ08,O43707,Q92621,P14174,Q9NQW6 9 +Chorioretinal dysplasia 0.3626192826587909 0.1542461843839258 0.8774156280200236 1.0 1.0 5 Q9H9S5,P53701,P52732,O43505 4 +Abnormal dental pulp morphology 0.325893882711746 0.1531567798556574 0.8782746401542487 1.0 1.0 8 P21359,Q13045 2 +Erythroid hyperplasia 0.3614825705180053 0.1517375078867529 0.8793939726724109 1.0 1.0 5 P37287,P06132 2 +Abnormality of thyroid physiology 0.2895020868733948 0.1496463668319645 0.8810436246046831 1.0 1.0 74 O14802,Q93008,Q92890,Q96J02,Q06787,Q07021,Q15046,P57081,Q9H1A4,Q9BUK6,P03886,P27635,Q6PGP7,P61978,Q12824,O76024,P25054,O14654,Q6W2J9,Q9Y3Z3,P31749,P40763,P42224,Q13045,P53992,Q99496,P21964,P49815 28 +Dilation of lateral ventricles 0.326249778000157 0.1489907568806545 0.8815609264990745 1.0 1.0 21 P67870,Q00610,Q9H553,Q01105,O75787,Q08209,P36776,O75340 8 +Deviation of the thumb 0.3258853015497605 0.1486247893665088 0.8818497111724337 1.0 1.0 18 Q96ST3,P34897,Q9BV10,Q9UBM7,P36776 5 +Otitis media 0.2438728319094453 0.1482424340395491 0.8821514442340002 1.0 1.0 52 O14802,Q14739,P29144,Q86UE8,O96028,P40763,Q05655,Q13045,P53992,Q92890,Q99496,Q6W2J9,Q9H1A4,Q9UBM7 14 +Truncal ataxia 0.325754288292526 0.1482041035893108 0.882181693387611 1.0 1.0 18 Q9BUK6,P34897,P98155 3 +Abnormal odontoid tissue morphology 0.2646805385218549 0.146595796614925 0.8834510716536255 1.0 1.0 43 Q15813,P25054,P61586,P51648,Q9HC07,P18074,P53992,Q9UBM7,P19447,Q9H1A4,P21359,P31749,P36776 13 +Genital neoplasm 0.2747727990043958 0.1462507126589204 0.8837234729942833 1.0 1.0 41 Q07864,P48735,Q01844,P54277,O75874,Q9UPY3,P52701,P31749 8 +Thickened skin 0.3437767261212352 0.1459907060851415 0.8839287252889652 1.0 1.0 102 O14802,P50452,O75381,Q13642,P19447,Q14739,P28070,Q06136,P37287,P15924,Q6DD88,O15270,A1X283,P31751,P06132,Q14574,Q9H1A4,P21359,Q9H4L7,Q7Z392,P40855,P18074,Q14691,O75844,P14923,P31749,Q96MF7,Q9NWM8,Q15555 29 +Mastoiditis 0.4382320726890412 0.1452801021895703 0.8844897241958178 1.0 1.0 3 Q15043 1 +Abnormality of the mastoid 0.4382320726890412 0.1452801021895703 0.8844897241958178 1.0 1.0 3 Q15043 1 +Abnormal renal vascular morphology 0.3339647982363881 0.1451133907193713 0.8846213459345855 1.0 1.0 7 P21359,O60333 2 +Weakness of long finger extensor muscles 0.6199868507560754 0.1440979050340912 0.8854231589984771 1.0 1.0 2 Q13501 1 +Abnormal form of the vertebral bodies 0.3064115560467461 0.1440312760280975 0.8854757724254185 1.0 1.0 83 Q14739,O14802,O95831,P48735,A1X283,Q7RTS9,Q99575,Q13045,Q32P28,Q6NUQ1,O75874,P21359,P31749,Q9UBM7 14 +Torsion dystonia 0.4371148471273401 0.143536748785774 0.8858662903838228 1.0 1.0 3 P04350 1 +Neoplasm of the genitourinary tract 0.2862282309410012 0.1432669267938669 0.8860793749376326 1.0 1.0 73 Q92733,P61313,Q07864,P18077,P48735,P25054,Q01844,P54277,O75874,P08708,Q9UPY3,Q99496,P52701,P46783,P21359,P49815,P31749,O60333 18 +Ectropion of lower eyelids 0.6180144641683075 0.1415351888598101 0.8874471631404468 1.0 1.0 2 Q99496 1 +Atrophy degeneration involving the caudate nucleus 0.4357994903368109 0.1415040816872295 0.8874717357690711 1.0 1.0 3 P42858 1 +Amyotrophic lateral sclerosis 0.3223398132947365 0.1373925711370856 0.8907205027382727 1.0 1.0 18 Q92804,P35637,Q99720 3 +Overlapping fingers 0.34132852664168 0.1372903118239621 0.8908013279694496 1.0 1.0 6 P78527 1 +Nevus 0.30297364718318 0.134507171186046 0.8930015408344709 1.0 1.0 33 P22681,P11802,P18074,P49815,P10412,P31749 6 +Macrodontia 0.3206979998429979 0.1340488504563227 0.8933639459062095 1.0 1.0 17 O60828,Q7LGA3 2 +Talipes equinovarus 0.2781247435146938 0.1331159641990764 0.8941016699015587 1.0 1.0 70 Q15392,P61978,Q9NWM8,A1X283,Q7RTS9,Q9BV10,P53992,Q6NUQ1,Q6W2J9,P10412,Q9Y487 11 +Abnormal circulating cholesterol concentration 0.3025936568551229 0.1331026259111606 0.8941122184503512 1.0 1.0 33 Q15392,Q14739,P42858,P37268,Q13045,Q8N511,Q9UBM7 7 +Premature rupture of membranes 0.3387851964783011 0.131400563422731 0.8954584429813006 1.0 1.0 6 O75844 1 +Abnormality of the breast 0.3460726910909789 0.130003379216923 0.8965637531535677 1.0 1.0 105 O14802,P48735,P22681,P19447,Q7LGA3,Q15067,Q07864,A1X283,Q9BV10,P31751,P21359,P52788,P23786,P61978,P11802,P18074,O75874,O14678,Q96EK5,P31749,Q9UBM7,Q9Y4A5,Q8IWS0,Q05655,P19022,Q15555 26 +Glomerular sclerosis 0.2986381618237204 0.1296929002999171 0.8968093998653235 1.0 1.0 34 P21359,P03886 2 +Self injurious behavior 0.2608344534149674 0.1288612538405414 0.897467435943297 1.0 1.0 43 P67870,P27635,Q4G0J3,Q06787,Q13045,P55795,P19022,Q8NB90,Q6W2J9,Q01105,Q9UBM7,P49815,Q08209,Q8NI27 14 +Abnormal elasticity of skin 0.2629248030750108 0.1285549612123953 0.8977098062382611 1.0 1.0 63 P17612,Q9NWM8,Q13126,A1X283,Q15555,Q9BV10,O75844,Q15334,Q12948,Q9Y487,Q9H4L7 11 +Unsteady gait 0.2442593126967437 0.1282464069879054 0.897953975790871 1.0 1.0 54 O75787,Q96F07,O95831,P42858,Q12873,Q2TAL8,Q96CW1,P18887,P52788,Q08209 10 +Abnormal hair laboratory examination 0.3271004100058858 0.1277152422452852 0.8983743273105886 1.0 1.0 7 P18074,P19447 2 +Disproportionate tall stature 0.3156141457766289 0.1268969329164441 0.8990219741958536 1.0 1.0 26 P42858,Q9NWM8,Q93074,P52788,Q7LGA3,P31749 6 +Myoglobinuria 0.3101130497473377 0.1264518842898531 0.8993742340008664 1.0 1.0 11 P23786,Q9H9S5,Q16836,P46020 4 +Abdominal obesity 0.42518908253864 0.1258898512206726 0.8998191163132294 1.0 1.0 3 O95714,Q13620 2 +Emg impaired neuromuscular transmission 0.3261214120633688 0.1253096357337722 0.9002784241021582 1.0 1.0 7 Q9Y5P6 1 +Abnormality of the lymph nodes 0.265046599111352 0.1249809977930604 0.9005385939369233 1.0 1.0 42 P29144,P28070,P22681,P40763,Q01844,Q05655,Q9NZ08,Q13546,Q14691,Q6W2J9,P14174,P49815 12 +Increased circulating igg level 0.348192400530905 0.1240305453697612 0.9012910900814088 1.0 1.0 5 Q05655,P29144,O95394 3 +Incomitant strabismus 0.3127022407279385 0.1236010168941135 0.9016311872969194 1.0 1.0 13 Q7LGA3 1 +Retrognathia 0.2881154066557098 0.1229338497435363 0.902159480698466 1.0 1.0 76 O14802,Q15392,O43776,Q96ST3,Q16625,P78318,P37268,Q13642,Q4J6C6,Q9UPT5,P18074,Q8NB90,P19447,O75844,Q7LGA3,Q96MF7 16 +Dermatological manifestations of systemic disorders 0.2636454756385203 0.1220170429007928 0.9028855208402724 1.0 1.0 64 Q14739,Q16625,O43772,Q6NUQ1,P13804,P39210,O75844,P40855 8 +Easy fatigability 0.3178081166950657 0.1219055061330672 0.902973854891336 1.0 1.0 20 Q15526,Q9Y5P6,P61978,Q9NWM8 4 +Brisk reflexes 0.3173893918163212 0.1216977942679939 0.903138360173458 1.0 1.0 22 O60508,P35637,Q99720,Q8TEQ6,P82663,Q9NW15 6 +Abnormal cortical bone morphology 0.3165661962297297 0.1215652816418244 0.9032433107420352 1.0 1.0 17 Q15813,A1X283,P21359,P31749,P40855 5 +Recurrent upper and lower respiratory tract infections 0.600591715976324 0.1204510604087026 0.9041258454365156 1.0 1.0 2 Q93008 1 +Microretrognathia 0.313073568473189 0.1204162116152569 0.9041534498324276 1.0 1.0 14 P27635,Q96ST3,Q16625,Q8WVQ1,Q96MF7 5 +Mediastinal lymphadenopathy 0.3338317792373405 0.1202725450751131 0.9042672520698578 1.0 1.0 6 Q01844 1 +Male reproductive system neoplasm 0.3149693796205919 0.1192669977535387 0.9050638288149292 1.0 1.0 16 P31749,Q01844,Q9UPY3,P25054 4 +Papilloma 0.3067392260152317 0.1167521656247545 0.9070564507167544 1.0 1.0 11 P18074,P31749,P19447 3 +Mania 0.3102232208083467 0.1164438818784291 0.9073007592011468 1.0 1.0 13 P53992,Q92890,P03886 3 +Premature skin wrinkling 0.3158082605577256 0.1158762737319321 0.9077505998246278 1.0 1.0 20 O14802,Q9Y487,O75844,Q93074 4 +Cogwheel rigidity 0.3547310287260489 0.1154538576840996 0.9080853920645192 1.0 1.0 4 O75787 1 +Cns hypomyelination 0.2805976818369936 0.1154221767106366 0.9081105019590752 1.0 1.0 38 P04350,O14802,P35637,Q99720,O75746,Q9H553,Q8NB90,P78527,Q7Z392 9 +Abnormal umbilicus morphology 0.2602040597955589 0.1152745803832996 0.9082274859448324 1.0 1.0 63 Q14739,Q9NWM8,Q15555,O75844,Q93074,P53992,P18074,P19447,Q6W2J9,Q9Y487,P42345,Q9Y4A5 12 +Prominent superficial blood vessels 0.3081108699007489 0.1152435819618221 0.90825205536538 1.0 1.0 12 O14802,O75844 2 +Paraparesis 0.3089943178172852 0.1151605488625728 0.9083178680242304 1.0 1.0 28 Q15813,Q8N0X7,Q6DKK2,P35637,Q6W2J9,P21359 6 +Abnormal blood inorganic cation concentration 0.2842148758938005 0.1144610937631835 0.9088722863305349 1.0 1.0 37 Q15813,P61457,Q15043,Q9NP81,Q9BV10,P53992,Q92890,P21964,P21359,Q4J6C6,O60333 11 +Microcornea 0.3087003951613669 0.114207031223686 0.9090736782708088 1.0 1.0 28 Q9NWM8,Q13045,P18074,Q6W2J9,P19447,Q15555,P36404 7 +Frontal cortical atrophy 0.3092829895464881 0.1137679426517055 0.909421751615112 1.0 1.0 13 Q7LGA3 1 +Solitary median maxillary central incisor 0.3531936115065879 0.112953714218674 0.9100672509876742 1.0 1.0 4 Q6W2J9 1 +Myalgia 0.2756437473574408 0.1120965672344473 0.9107468392223772 1.0 1.0 39 P23786,O14802,Q14739,P25054,Q9H9S5,Q9NZ08,P53992,Q92890,P46020,Q9BUK6,Q7Z392 11 +Renal tubular dysfunction 0.2903238681755639 0.1110809681544982 0.9115521405458776 1.0 1.0 35 P11498,P37287,P28331,O75306,Q86Y39,Q15526,Q4G0N4,P13804,Q96CU9,P03886,P40855 11 +Abnormal renal cortex morphology 0.242456185594421 0.1090564438653757 0.9131577215262656 1.0 1.0 55 P21359,Q96J84,P03886,Q9NZ08 4 +Leiomyosarcoma 0.3017116626772365 0.1086219263743257 0.9135023689226576 1.0 1.0 10 P31749 1 +Abnormalities of placenta or umbilical cord 0.311193194362004 0.1083825391115706 0.913692251309635 1.0 1.0 16 Q2TAL8,O75844,Q9H4L7 3 +Blepharophimosis 0.2506711138108574 0.10728533981448 0.9145626145454556 1.0 1.0 44 Q86UE8,Q15555,Q93074,Q6W2J9,O75844,Q7LGA3 6 +Nephritis 0.3121470544919952 0.1072190751242543 0.9146151828997188 1.0 1.0 23 Q8NFH4,P49327,Q9P2R3,Q05655,Q12769,O95394,P53621,O43707,Q92621,Q9NQW6,Q96J84 11 +Unilateral renal agenesis 0.3122025399913201 0.107051534793156 0.9147480957648826 1.0 1.0 18 P35606,Q9UBM7,Q7LGA3,P30153 4 +Interrupted aortic arch 0.5880999342537733 0.1070175380265466 0.9147750663240988 1.0 1.0 2 P53597 1 +T lymphocytopenia 0.3083686853116884 0.1060444265563508 0.9155471035911832 1.0 1.0 8 P49327,O14920,Q05655,Q13546,O95394 5 +Albinism 0.4088960522099688 0.1045889655093459 0.916701970928674 1.0 1.0 3 O14617 1 +Decreased circulating igg level 0.2999850570257466 0.1038953626749459 0.9172523872419376 1.0 1.0 10 P18074,P17812 2 +Esophagitis 0.2976228970978202 0.1038364227237885 0.9172991615338556 1.0 1.0 9 P78330 1 +Gonadal dysgenesis 0.302081640015827 0.1038009831266745 0.9173272862633732 1.0 1.0 11 P18074,P19447 2 +Limited elbow movement 0.2812926517883977 0.1036822738647493 0.9174214942357656 1.0 1.0 37 P23786,Q7RTS9,Q7LGA3,Q93074 4 +Rheumatoid factor positive 0.3369155678331134 0.1028832748383893 0.9180556119982884 1.0 1.0 5 Q13546,Q05655,O95394 3 +Lipodystrophy 0.2842281150092326 0.1013948997158845 0.9192369850469002 1.0 1.0 36 O14802,P28070,P15924,P31751,Q9Y3Z3,O75844 6 +Abnormal incisor morphology 0.3043494499865799 0.1000774521782401 0.9202828360052082 1.0 1.0 13 Q7LGA3 1 +Incisor macrodontia 0.3043494499865799 0.1000774521782401 0.9202828360052082 1.0 1.0 13 Q7LGA3 1 +Impaired proprioception 0.2982111806648899 0.0998664886117561 0.920450321524571 1.0 1.0 31 O14802,Q8N0X7,Q13217,P41440,P18887 5 +Episodic ataxia 0.4048010522854331 0.0997347415122847 0.920554918301414 1.0 1.0 3 P11166,Q9H936 2 +Scaling skin 0.2958639055195572 0.0991074016718558 0.9210529953397096 1.0 1.0 9 O75844 1 +Tube feeding 0.2443659021970306 0.0986728580138797 0.9213980198397044 1.0 1.0 57 P61978,P30153,P37268,P35637,Q9BV10,Q99720,Q96F86,Q8NB90,Q9NZ01,Q9H1A4,Q9H490,Q96J02,Q9NUQ7,Q01105,Q08209,P36776,Q9UBB6 17 +Neoplasm of the large intestine 0.2317235639639644 0.098239761512292 0.9217419100284774 1.0 1.0 47 P61313,Q07864,P18077,P25054,P54277,P08708,Q9UPY3,P52701,P46783,P31749 10 +Abnormality of vitamin k metabolism 0.3227203917390555 0.0969720018983916 0.9227486288854544 1.0 1.0 6 Q9UDY2 1 +Somatic sensory dysfunction 0.3174548449423208 0.0962772853191602 0.9233003509588632 1.0 1.0 94 O14802,Q8N0X7,O43776,O95831,P39210,P41440,P07384,O15270,Q6DD88,Q15046,Q9NZ08,P06132,P18887,Q9BUK6,P61978,Q13217,P54277,Q13045,Q15120 19 +Functional abnormality of the middle ear 0.3058343425776946 0.0961831428358397 0.923375118805486 1.0 1.0 88 P61978,O95831,Q9NWM8,P78318,P50213,Q92620,P62266,O75844,Q13045,P53992,P21359,Q15555,Q7LGA3,O43924 14 +Abnormality of vitamin metabolism 0.3038105417377877 0.0941299920415014 0.925005895943854 1.0 1.0 27 O14678,P41440 2 +Stomatitis 0.3045992077759833 0.093173883919027 0.925765421729544 1.0 1.0 15 Q05655,Q6W2J9,Q9NZ08,P78527 4 +Abnormal 2nd finger morphology 0.3204736886340359 0.0925413330805174 0.9262679530451275 1.0 1.0 6 P27635,Q93074 2 +Non hodgkin lymphoma 0.2951785460602341 0.091107930973555 0.927406830849467 1.0 1.0 10 Q05655,Q07864 2 +Small anterior fontanelle 0.568376068376059 0.088549026701105 0.9294403196669656 1.0 1.0 2 P26640 1 +Psychosis 0.2985289734319961 0.0879794890386741 0.9298929782934552 1.0 1.0 29 Q6DKK2,Q8N0X7,P03886,Q93074 4 +Fatigable weakness of swallowing muscles 0.3023966419681305 0.0873343052483849 0.9304057865399202 1.0 1.0 15 Q92804 1 +Multiple renal cysts 0.3034736719832593 0.087257186706688 0.9304670842271838 1.0 1.0 16 P53992,Q92890,P49815,O60231 4 +Abnormal atrioventricular valve morphology 0.2862065757777525 0.0865613377845356 0.931020198481473 1.0 1.0 34 Q93074,P55795,P53992,Q6W2J9,P21359,O75844 6 +Multiple cafe au lait spots 0.2992410869282834 0.0865279827313126 0.9310467124826564 1.0 1.0 13 P21359,P31749 2 +Congenital bilateral hip dislocation 0.5634451019066341 0.0844351473431486 0.9327104635110248 1.0 1.0 2 Q9Y4R8 1 +Decreased absent ankle reflexes 0.2944860769195536 0.0837888664900389 0.9332243001447214 1.0 1.0 11 Q13501,O95394,Q15120,O75787 4 +Broad based gait 0.3029528617495408 0.0799570311650493 0.9362714306667592 1.0 1.0 22 P98155,P42858,Q12873,Q93074,P52788 5 +Axial muscle weakness 0.3228662105766448 0.0795651895411083 0.9365830821308864 1.0 1.0 5 Q9Y5P6 1 +Abnormality of the adrenal glands 0.240029973085991 0.0794608949817372 0.9366660345087404 1.0 1.0 57 P17612,Q07864,Q12824,P48735,O75381,Q7Z392,O75874,Q6W2J9,P21359,P82663,O75844,Q9Y2R9,P31749,P40855,O60333 15 +Abnormal delivery 0.3028074325479073 0.0791636691278127 0.9369024417048316 1.0 1.0 21 O14802,O75844,Q9UBM7 3 +Telangiectasia of the skin 0.3013774551210045 0.0755958342423983 0.9397406507753684 1.0 1.0 20 P21359,P18074,Q14739,Q07864 4 +Pelvic girdle muscle weakness 0.2954591451174238 0.075571891236258 0.9397597000390548 1.0 1.0 8 Q9H9S5,O14979 2 +Alacrima 0.3191839420862212 0.0740029895220504 0.9410080064909698 1.0 1.0 5 P55011,Q96IJ6,O95163,Q7Z392 4 +Pancreatic adenocarcinoma 0.2903704825568368 0.0735261712033584 0.9413874188250332 1.0 1.0 11 P54277 1 +Elevated circulating follicle stimulating hormone level 0.3250000000000103 0.073501346206692 0.941407172856326 1.0 1.0 4 Q8IY37,P16435,Q96MF7 3 +Decreased fertility in females 0.3250000000000076 0.0735013462066889 0.9414071728563284 1.0 1.0 4 Q8IY37,Q86Y56,Q15645 3 +Hemolytic anemia 0.2893082290661742 0.0726122499948171 0.9421146783689692 1.0 1.0 31 P00390,P29144,P08237,P41440,P37287,P40763,P42224,Q05655,P06132 9 +Abnormal circulating igg level 0.2949297096626446 0.0717593036026277 0.94279346030632 1.0 1.0 14 P18074,Q05655,Q9BV10,P17812 4 +Increased circulating igm level 0.2936876094387221 0.0716756066174292 0.9428600693199444 1.0 1.0 8 Q9Y5L0,P29144,O95394,P49327 4 +Abnormality of the testis size 0.2928748005071531 0.0715664883459297 0.9429469100900654 1.0 1.0 29 P27635,Q93074,P18074,O60828,P19447,P21359,P31749,Q8NI27,Q8IWS0 9 +Cerebral visual impairment 0.2460723873877811 0.0707466393654775 0.9435994009584704 1.0 1.0 61 P30153,Q96CU9,P35606,P37287,Q12873,P37268,P03886,Q96F86,Q8NB90,Q4G0N4,Q9NZ01,Q01105,Q9H490,Q9NUQ7,Q08209 15 +Pancreatic fibrosis 0.5447074293228031 0.0705305278490384 0.9437714033352048 1.0 1.0 2 O15078 1 +Abnormal circulating hormone concentration 0.3009613695477295 0.0687484893984064 0.9451898205197492 1.0 1.0 89 O14802,P50213,P17612,Q15813,Q07864,Q16836,Q9BV10,P57081,P31751,P21359,O60333,Q12824,O14654,O75844,Q96MF7,P31749,Q92620,Q15555,Q4J6C6 19 +Focal t2 hyperintense brainstem lesion 0.2946856765132832 0.0678599459806124 0.9458971236957394 1.0 1.0 15 P28331,P03886,O75306,Q86Y39 4 +Barrett esophagus 0.5378040762656037 0.0660636231995806 0.9473271720374914 1.0 1.0 2 O60216 1 +Jaundice 0.2244808688150767 0.0658126923068544 0.947526951145826 1.0 1.0 51 Q14739,Q6PGP7,P08237,P00374,Q16625,O75381,P37287,Q16134,P11171,Q6NUQ1,P13804,Q9Y3Z3,O75787,P39210,P40855 15 +Proptosis 0.2425392087175006 0.0646897782391373 0.9484210015594936 1.0 1.0 60 P61978,Q12824,A1X283,P22681,P57081,Q32P28,Q12948,Q9UBM7,P21359,P52788,O75844,P31749 12 +Potter facies 0.5355029585798721 0.0646492093949826 0.948453303198179 1.0 1.0 2 P22314 1 +Hand tremor 0.2842946822166623 0.0641901052084764 0.948818856047251 1.0 1.0 10 Q16637 1 +Abnormal chorioretinal morphology 0.2965612460712201 0.0641608995176707 0.9488421108802338 1.0 1.0 23 O75381,Q9H9S5,Q6W2J9,P49815,P31749,P40855 6 +Myofibrillar myopathy 0.3115816602513088 0.0632282802566334 0.9495847254400462 1.0 1.0 5 P31749 1 +Gonadal neoplasm 0.2914221472339987 0.0631708753333977 0.9496304365614114 1.0 1.0 28 P48735,Q01844,P54277,O75874,P52701,P31749 6 +Open operculum 0.5315581854043276 0.0623089790358232 0.9503167781362312 1.0 1.0 2 P07954 1 +Abnormality of the basal ganglia 0.2738140681903457 0.0619817267579535 0.9505773839531964 1.0 1.0 76 Q15813,O14802,P23786,O95831,P42858,Q7KZN9,P28331,O75306,Q15526,Q9BSH4,Q4G0N4,P19447,Q9NZ01,Q9Y3Z3,P03886 15 +Facial edema 0.2922421072954101 0.0617016486190494 0.9508004270648738 1.0 1.0 27 Q8NFH4,P28070,Q14331,P78330,Q92621 5 +Male pseudohermaphroditism 0.3610654390003282 0.0595269299941433 0.952532416470538 1.0 1.0 3 O15078,P53701 2 +Pallor 0.2187309364475312 0.0591689201180236 0.9528175644087038 1.0 1.0 49 P61313,Q9H061,P18077,O75533,O43172,P00374,P11171,Q9Y5L0,P08708,P46783,Q9BUK6,P21359,Q02241,O60333 14 +Macrocytic anemia 0.270958409603535 0.0584334786554626 0.9534033482105152 1.0 1.0 36 P61313,P18077,P41440,O76024,P00374,P08708,P46783,Q9P2J5 8 +Peripheral pulmonary artery stenosis 0.2790998679588415 0.0577088542896271 0.9539805407490762 1.0 1.0 9 Q6W2J9 1 +Aplasia hypoplasia involving bones of the thorax 0.2673917358499683 0.057686806912951 0.9539981027538844 1.0 1.0 37 Q7RTS9 1 +Deep palmar crease 0.285112709486323 0.0564564257708996 0.954978207325538 1.0 1.0 12 P61978,P42345 2 +Irritability 0.2723008806891907 0.0563409103819754 0.9550702288029972 1.0 1.0 76 Q15067,O95831,Q12824,O43772,P26358,P28331,P37268,Q9NZ08,P54277,P50747 10 +Abnormal metabolism 0.2219879589178633 0.0558771315425383 0.955439688746332 1.0 1.0 51 Q9UDY2,P41440,P18074,Q9H553,P19447,O14678,O75787,P46783,Q8N511,Q9Y487 10 +Narrow palm 0.3552855676383136 0.055671813803648 0.9556032539932944 1.0 1.0 3 P52788 1 +Gout 0.355146333442948 0.0555827324587869 0.9556742207384884 1.0 1.0 3 P00492,P08237 2 +Abnormal meningeal morphology 0.2913912740757114 0.054290532378451 0.9567036924976592 1.0 1.0 25 O43776,Q9H9S5,Q9Y5P6,P53992,P21359 5 +Abnormality of blood circulation 0.2695714868299813 0.053565176248173 0.9572816019890872 1.0 1.0 75 P23786,Q14739,Q12824,P05165,P22681,Q9NZ08,O75844,P53992,P54277,Q6W2J9,Q02241,P21359,Q9Y487,P49815,P31749 15 +Abnormality of the maxilla 0.2750299285404307 0.0530835464219127 0.9576653410211856 1.0 1.0 34 P17612,Q14739,Q93074,Q12948,Q96EK5,P31749 6 +Asthma 0.2915735550656052 0.0523422624572768 0.958255978879909 1.0 1.0 19 P53992,P18074,Q92890,Q9UJV9,Q93009,P21964,P42345 7 +Autism 0.2205258594607898 0.0518670196030925 0.95863465343273 1.0 1.0 47 P27635,Q00610,Q96F07,Q96ST3,O76024,Q06787,Q93074,P53992,Q92890,Q9UBM7,P21964,P49815,Q08209,P31749,Q15233 15 +Simple febrile seizure 0.3472506707684968 0.0508126822881528 0.9594747849284112 1.0 1.0 3 Q96CW1 1 +Cardiac arrest 0.2830925264782356 0.050120122316966 0.9600266645986651 1.0 1.0 30 P14923,O43772,P15924,P31749 4 +Bulbous nose 0.2447510457924234 0.0486818514828778 0.9611728391439796 1.0 1.0 42 P23786,Q06787,Q2TAL8,Q93074,P53992,Q92890,P60953,O60828,O00571,P21964,Q96EK5,P52788,Q9Y4A5 13 +Abnormal phalangeal joint morphology of the hand 0.2641653153677704 0.0482581599482265 0.9615104992030594 1.0 1.0 37 O14802,P57081,Q93074,P18074,Q6W2J9,O75844,Q9H4L7 7 +Abnormal brainstem morphology 0.2912056600012112 0.0473417203992653 0.9622408772713348 1.0 1.0 87 P98155,O95831,Q15526,P30153,P37287,P07942,P26358,P28331,Q9UPT5,P03886,Q12824,Q13217,Q9H9S5,O75306,Q86Y39,Q9Y5P6,Q96EK5,P31749,Q9Y4A5 19 +Hepatocellular carcinoma 0.2895977084823397 0.0472262569626731 0.9623329008351382 1.0 1.0 23 Q9UDY2,Q05655,P54277,P06132,P52701 5 +Pes planus 0.2655888464684103 0.0463848607048856 0.9630035029322856 1.0 1.0 74 P98155,P61978,Q86UE8,Q9NWM8,Q7RTS9,Q15555,Q93074,Q9Y5P6,P55795,Q9H553,Q15334,Q13045,Q9Y487,P42345 14 +Cutaneous syndactyly 0.2803141350664334 0.0458248263083583 0.96344987106009 1.0 1.0 12 Q6W2J9,Q9H4L7 2 +Eeg with continuous slow activity 0.3364024991779048 0.0451165243961888 0.9640144302703052 1.0 1.0 3 Q13501,P55072 2 +Collectionism 0.3364024991779048 0.0451165243961888 0.9640144302703052 1.0 1.0 3 Q13501,P55072 2 +Lack of insight 0.3364024991779048 0.0451165243961888 0.9640144302703052 1.0 1.0 3 Q13501,P55072 2 +Abnormal circulating sex hormone concentration 0.2888760306259312 0.0450038899447761 0.9641042083700472 1.0 1.0 22 O14802,Q12824,Q13144,Q9NR50,Q9UI10,Q99496,Q13423,P31749,P82650,P49770 10 +Spontaneous abortion 0.4937541091387107 0.0447877139158907 0.9642765181414056 1.0 1.0 2 Q9NQX3 1 +Unilateral ptosis 0.3355485945564429 0.0447079705266477 0.9643400804909732 1.0 1.0 3 P52788 1 +Thoracic kyphoscoliosis 0.2917621557406774 0.0441763412176057 0.9647638406116236 1.0 1.0 6 O75844 1 +Abnormality of the periorbital region 0.2528614083174595 0.0434005369472866 0.9653822496840828 1.0 1.0 68 Q8NFH4,Q6PGP7,P28070,Q8IWS0,Q14331,O75381,P78330,P62266,P57081,Q13642,Q93074,O14646,Q7LGA3,P40855 14 +Psoriasiform dermatitis 0.2937500000000042 0.0430247359625472 0.9656818156608088 1.0 1.0 4 P10321,Q15800,P01889 3 +Laryngomalacia 0.2812629254767634 0.0405516949196943 0.967653294321296 1.0 1.0 14 P27635,O14802,P25054,P53992,Q92890 5 +Patent ductus arteriosus 0.281471544205296 0.0405435721446585 0.9676597700325068 1.0 1.0 83 Q15392,Q12824,Q9NWM8,P78318,Q96PU5,O14497,Q12948,Q6W2J9,O75844,Q9UBM7,P40855,Q9Y4A5 12 +Abnormal serum interferon level 0.2912520241319948 0.0389418283858305 0.9689367676158132 1.0 1.0 5 Q9Y3Z3 1 +Perseveration 0.272579961717561 0.0384088404015846 0.9693617125632428 1.0 1.0 10 Q13148,P35637,Q93009,Q9BSH4,Q15233 5 +Hyperkalemia 0.2872517395078899 0.0382480379446552 0.9694899201533188 1.0 1.0 4 P11166,Q13423 2 +Abnormal blood chloride concentration 0.4671268902038011 0.0369017250238126 0.9705633643155926 1.0 1.0 2 Q13618 1 +Epicanthus inversus 0.3156856297270652 0.0366857170649421 0.9707355971087106 1.0 1.0 3 Q16531,O14974 2 +Abnormal cerebellar vermis morphology 0.2643242353268992 0.0354205616750067 0.9717443891525188 1.0 1.0 75 O14802,Q8NFH4,P42858,O14497,Q9Y487,P07942,P43034,Q12948,P78527,Q9H490,O43924,P23786,Q12824,Q9H9S5,Q9Y5P6,Q15334,Q6W2J9,Q9UBM7,Q9Y4A5 19 +Nocturnal seizures 0.4605522682445672 0.0354059852682888 0.971756012151904 1.0 1.0 2 Q9NQX3 1 +Congenital onset 0.3123121035995618 0.0353403741809889 0.9718083294838872 1.0 1.0 100 P17612,Q15813,P11498,P98155,O14802,Q07864,P78318,Q96PU5,P34897,Q15046,P57081,Q9Y5P6,Q7LGA3,O14678,Q96EK5,Q4J6C6,O43924,Q9NQ48 18 +Crumpled long bones 0.45890861275476 0.0350566065112751 0.972034603113209 1.0 1.0 2 O75718 1 +Temporal optic disc pallor 0.455621301775134 0.0343860250000101 0.9725693273169618 1.0 1.0 2 O60313 1 +Morning glory anomaly 0.455621301775134 0.0343860250000101 0.9725693273169618 1.0 1.0 2 O60313 1 +Abnormality of the epiphyses of the distal phalanx of finger 0.4536489151873648 0.0340012204957147 0.9728761774503532 1.0 1.0 2 Q9Y2Q9 1 +Limb joint contracture 0.3080694894938418 0.033816336625488 0.9730236086527836 1.0 1.0 98 Q15392,O14802,Q7LGA3,A1X283,P15924,P35637,P57081,Q93074,Q99720,Q9H553,Q9H4L7,P23786,Q5JTV8,P37268,Q9H9S5,Q9Y5P6,P18074,Q6W2J9,O75844,P14923,O60828 21 +Lack of peer relationships 0.3017602226196988 0.0325554274114494 0.9740291147448744 1.0 1.0 3 Q96CW1 1 +Ovarian cyst 0.2785431631890039 0.0319968309244727 0.9744745781608976 1.0 1.0 15 P31751 1 +Focal tonic seizure 0.4385272846811259 0.0314532996852202 0.9749080351519366 1.0 1.0 2 Q00577 1 +Ureterocele 0.4385272846811265 0.0314532996852202 0.9749080351519366 1.0 1.0 2 Q15149 1 +Spastic tetraparesis 0.2821569294426464 0.030695525920101 0.9755123592813376 1.0 1.0 23 Q7RTS9,Q9BSH4 2 +Abnormality of the extraocular muscles 0.4243918474687658 0.0296338486019564 0.976359069880126 1.0 1.0 2 Q9BVA1 1 +Congenital localized absence of skin 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 1.0 2 Q15149 1 +Aplasia cutis congenita over the scalp vertex 0.4211045364891465 0.0292775371155623 0.9766432420064646 1.0 1.0 2 Q15149 1 +Abnormality of the larynx 0.2139173362895948 0.0289126407756455 0.97693426395613 1.0 1.0 47 P27635,O14802,Q14739,Q92804,P35637,P53992,Q9UBM7,P52701,P36776 9 +Abnormal circulating phenylalanine concentration 0.2772114436040819 0.0276165196153758 0.9779680059427732 1.0 1.0 3 P61457,P09417 2 +Gastrointestinal carcinoma 0.2673593027301071 0.027047049101645 0.9784222079852228 1.0 1.0 33 P61313,Q07864,P18077,P25054,P08708,P52701,P46783,P31749 8 +Decreased proportion of cd3 positive t cells 0.3905325443786924 0.0269124663016881 0.978529550448584 1.0 1.0 2 O95394 1 +Elevated tissue non specific alkaline phosphatase 0.385272846811304 0.0266445384304851 0.9787432493255788 1.0 1.0 2 Q13043 1 +Retinal perforation 0.3833004602235313 0.0265523821282836 0.978816753410396 1.0 1.0 2 P04439 1 +Spontaneous hemolytic crises 0.3708086785009817 0.0260616452926879 0.9792081692861389 1.0 1.0 2 P11166 1 +Increased megakaryocyte count 0.2604406445248342 0.0255414799103001 0.9796230630844664 1.0 1.0 3 P04637,O75533 2 +Hypoplastic heart 0.3208415516107812 0.0251541878560099 0.9799319781763014 1.0 1.0 2 O60826 1 +Decreased circulating aldosterone level 0.3188691650230116 0.0251392388498085 0.979943901986899 1.0 1.0 2 Q13423 1 +Abnormal platelet granules 0.2758053911900097 0.0249772278703003 0.9800731274683054 1.0 1.0 2 Q86YV9 1 +Abnormal cd4 cd8 ratio 0.2760776571240657 0.0248238724321487 0.9801954494766132 1.0 1.0 5 Q9H0U3,O75083,O95394,P17812 4 +Peripheral hypomyelination 0.2403814534692618 0.0240143892854001 0.980841131027308 1.0 1.0 3 P19367,O60231 2 +Urticaria 0.2694782548906657 0.0238952419611551 0.9809361695656816 1.0 1.0 12 P22681,Q05655,P51648,P18074,P19447 5 +Nonimmune hydrops fetalis 0.2750173129323393 0.0238627896365594 0.9809620553932404 1.0 1.0 28 Q14739,P06132 2 +Chronic kidney disease 0.2607940371947662 0.0236427203946122 0.9811375957170148 1.0 1.0 35 P23786,Q8NFH4,Q9NP81,Q05655,Q92621,P49815,Q9NQ48 7 +Abnormal mitochondrial shape 0.2582236842105321 0.022398155244315 0.9821303518855632 1.0 1.0 4 Q7Z406,P53597,Q00325 3 +Glaucoma 0.2884412395479133 0.0202642487764462 0.9838325752705288 1.0 1.0 90 P61313,P50213,Q06136,A1X283,Q12948,P21359,P46783,P40855,Q6PGP7,Q9H9S5,Q9Y5P6,Q6W2J9,Q9Y3Z3,P31749,Q9UBM7,Q92620,P53992,P08708,Q15555 19 +Abnormal t cell subset distribution 0.2654878177713919 0.0202518577599554 0.9838424598428128 1.0 1.0 11 P17812,O75787 2 +Difficulty climbing stairs 0.2690729045823732 0.0196918643564586 0.9842891808259252 1.0 1.0 13 Q9Y5P6,Q9H553 2 +Bladder neoplasm 0.265127426890047 0.0195903062293906 0.984370196859127 1.0 1.0 11 P31749 1 +Abnormal eosinophil morphology 0.2686355845012439 0.0177946477136381 0.9858026745909512 1.0 1.0 7 P40763,Q05655,O95394 3 +Pulmonary hypoplasia 0.2731758330648486 0.0176484815389877 0.985919280013284 1.0 1.0 27 Q14739,O75844,Q9UBM7,P13804 4 +Abnormal blood glucose concentration 0.2779439461086786 0.0175880669313739 0.98596747641519 1.0 1.0 85 P23786,P11498,P05165,Q16836,O43772,P28331,Q96RQ3,O75306,Q4J6C6,P31751,P13804,P39210,O75844,P03886,P42345 15 +Reticulocytosis 0.2653876756728263 0.0163587047669105 0.9869482241592578 1.0 1.0 12 P08237,P37287,P11171,Q05655,P11166 5 +Abnormal tricuspid valve morphology 0.2628788465667906 0.0155325898417372 0.9876072846918632 1.0 1.0 11 P53992,Q92890,P21964,Q15233 4 +Developmental cataract 0.2201542921092268 0.0151651374088247 0.9879004347799656 1.0 1.0 56 P61313,P18077,O76024,Q16134,P18074,P08708,P19447,P13804,Q9H1A4,P46783,Q6W2J9,Q5SRE5,P03886,P36776,O60333 15 +Abnormal clavicle morphology 0.2742963286571921 0.0147542856233025 0.988228210395116 1.0 1.0 22 Q15813,Q14739,O75844,Q6W2J9 4 +Vocal cord paralysis 0.2725256924630369 0.0143795740979135 0.9885271552151826 1.0 1.0 18 P21359,O60333,Q13642 3 +Abnormal cranial nerve morphology 0.2395195485284378 0.0136444481703768 0.989113643252488 1.0 1.0 66 Q15043,Q12824,Q14331,Q86U42,P34897,Q15046,Q9H9S5,Q93074,Q9Y5P6,Q9H553,P22626,P21359,P31749,P40855,O60333 15 +Retinal arteriolar tortuosity 0.2593278781750031 0.0132196544564967 0.989452549021702 1.0 1.0 10 P53992,Q92890,P21964 3 +Adenocarcinoma of the colon 0.2726952776434604 0.0125303388132975 0.9900024977368822 1.0 1.0 20 P61313,Q07864,P18077,P08708,P46783 5 +Spinal cord compression 0.263462167813145 0.0112893655825015 0.9909925808331272 1.0 1.0 7 P31749,O60333 2 +Abnormality of the plantar skin of foot 0.2354688160636341 0.0111633595893264 0.9910931127343052 1.0 1.0 41 P61978,Q06136,P15924,P42345,P14923,P31749,Q9H4L7 7 +Deviation of the hallux 0.2686794364696236 0.011011040068162 0.9912146386588564 1.0 1.0 28 P42858,Q6DD88,Q13642,Q96J02,Q7LGA3,P31749 6 +Aplasia hypoplasia involving the nose 0.2691175659991736 0.0097454990429823 0.9922243398583784 1.0 1.0 27 P55795,P61978,Q8NB90 3 +Abnormality of skin physiology 0.2903074511438553 0.0095233438873839 0.9924015858004096 1.0 1.0 93 O14802,P22681,P19447,P17612,Q14739,Q07864,P28070,Q06136,A1X283,P15924,Q9NZ08,P06132,P50747,Q9H4L7,Q9UDY2,P18074,Q14691,Q9Y3Z3,Q9UBM7,P05165,P53992 21 +Proximal tubulopathy 0.2711500630617898 0.0092090874178057 0.9926523151866032 1.0 1.0 21 P28331,Q16134,O75306,Q86Y39,P13804,Q96CU9,P03886 7 +Hypoamylasemia 0.2523856531753966 0.0087625958856335 0.993008549501271 1.0 1.0 5 Q9Y3A5,A5YKK6,P61011,Q5F1R6 4 +Paroxysmal involuntary eye movements 0.2677286430046739 0.0075241859896251 0.993996624811544 1.0 1.0 17 O43676,P28331,O75306,Q86Y39,Q96CU9,P03886,Q9BU61 7 +Cns demyelination 0.2602607054528676 0.0074779238086317 0.9940335356530804 1.0 1.0 12 Q15067,Q13144,Q9NR50,Q14232,Q9UI10,P51648,P40855,P49770 8 +Abnormal sacrum morphology 0.2656810222748325 0.0053701094370887 0.995715293184118 1.0 1.0 28 Q14739,Q93074 2 +Hallux valgus 0.2661363620185759 0.0048409758745791 0.9961374751768688 1.0 1.0 17 Q93008,Q6DD88,Q13642,Q96J02,P31749,Q15233 6 +Webbed neck 0.243171622091718 0.0043201595553154 0.9965530221128842 1.0 1.0 38 P61313,P18077,P22681,P52788,P60953,P08708,Q6W2J9,P46783,P21359,O75844 10 +Decreased circulating androgen concentration 0.2561896763558131 0.004167272007304 0.9966750076284316 1.0 1.0 11 Q12824 1 +Adenocarcinoma of the intestines 0.2679851575403089 0.0040281312651054 0.9967860249462625 1.0 1.0 24 P61313,Q07864,P18077,P25054,P08708,P46783 6 +Ankle clonus 0.2615122523465398 0.0036766379712779 0.9970664739361286 1.0 1.0 14 Q15043,Q8N0X7,P07384,P42858,O75787 5 +Abnormal mitochondria in muscle tissue 0.2649054276248047 0.0012986782730918 0.9989638049477184 1.0 1.0 18 P28331,P03886,O75306 3 +Aganglionic megacolon 0.2657873050115699 0.0006467470989064 0.9994839705110128 1.0 1.0 20 Q96EK5,Q9UBM7,Q6W2J9 3 +Dilated fourth ventricle 0.2306693378582025 0.0002028194846707 0.9998381734656608 1.0 1.0 41 P23786,O14802,Q12824,O14497,Q9Y5P6,Q6W2J9,Q9Y487,Q9UBM7 8 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bb5c2020f762fb2485cb2d35d9238dafd481c814 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowman capsule morphology", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal coccyx morphology", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal haptoglobin level", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the dental root", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal tarsal ossification", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of olfactory lobe morphology", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the hallux", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the first metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of venous physiology", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acromicria", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical adenoma", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal fissure", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Anuria", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanges of the toes", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hallux", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad long bones", "Broad metacarpals", "Broad metatarsal", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Budd chiari syndrome", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac rhabdomyoma", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clinodactyly of the 2nd finger", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Conjunctival icterus", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery aneurysm", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crossed fused renal ectopia", "Crumpled long bones", "Cryptophthalmos", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular hemoglobin concentration", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased thyroid stimulating hormone level", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of the distal phalanx of the thumb", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Ganglioneuroblastoma", "Ganglioneuroma", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Helicobacter pylori infection", "Hemangioblastoma", "Hemangiomatosis", "Hematochezia", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemolytic uremic syndrome", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the primary teeth", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired renal concentrating ability", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal bleeding", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular iliac crest", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Kinked brainstem", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct aplasia", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lenticonus", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limbal dermoid", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobar holoprosencephaly", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Meningoencephalocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microangiopathic hemolytic anemia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thymus", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncommunicating hydrocephalus", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuchal rigidity", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic endocrine tumor", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid hyperplasia", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the distal phalanges of the hand", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Photosensitive tonic clonic seizure", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Placental abruption", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Popliteal pterygium", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posterior uveitis", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent coccyx", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Reflex seizure", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Remnants of the hyaloid vascular system", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal nonattachment", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rhizomelic arm shortening", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shortening of all phalanges of the toes", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small pituitary gland", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue neoplasm", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hematomas", "Spontaneous hemolytic crises", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous lipoma", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thrombophlebitis", "Thymus hyperplasia", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "True hermaphroditism", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral atresia", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Wide pubic symphysis", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced primary teeth", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AKT1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG12", "ALG2", "ANAPC1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APOB", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARL2", "ARL3", "ARPC1B", "ARV1", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATL3", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BAG3", "BANF1", "BAX", "BAZ1B", "BCAP31", "BCAT2", "BCL10", "BCOR", "BCS1L", "BLVRA", "BMS1", "BRAT1", "BRCA1", "BRD4", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANT1", "CAP2", "CAPN1", "CAPN5", "CARS", "CAST", "CBFB", "CBL", "CCDC22", "CCDC47", "CCT5", "CD2AP", "CD320", "CD3EAP", "CD46", "CDC40", "CDC42", "CDC45", "CDC73", "CDH2", "CDK13", "CDK4", "CDK5", "CELF2", "CEP290", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD3", "CHD4", "CHEK2", "CHMP1A", "CHMP2B", "CHORDC1", "CHUK", "CISD2", "CIZ1", "CLASP1", "CLCC1", "CLCN7", "CLIP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNOT1", "CNP", "COA3", "COA7", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX15", "COX2", "COX4I1", "COX5A", "CPE", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "DARS", "DARS2", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DKC1", "DLAT", "DLD", "DLG3", "DLST", "DNA2", "DNAAF5", "DNAJC13", "DNAJC21", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPYSL5", "DSC2", "DSC3", "DSG2", "DSP", "DYM", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EGFR", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "ELP4", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC4", "ERGIC1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC9", "EZR", "FAH", "FAM50A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FDXR", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATB", "GATC", "GBA", "GCDH", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HCCS", "HCFC1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIRA", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IGF2R", "IKBKB", "IMPAD1", "IMPDH1", "INF2", "IRS4", "ISCU", "ITCH", "ITM2B", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KIAA0319L", "KIF11", "KIF1A", "KIF1B", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KIRREL1", "KMT2A", "LAMB1", "LAMC1", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDLR", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MANBA", "MAP1B", "MAP2K1", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MECR", "MED12", "MED17", "MESD", "MFSD8", "MIA3", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MOGS", "MORC2", "MPG", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCDN", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEU1", "NF1", "NFS1", "NHLRC2", "NHP2", "NID1", "NIPBL", "NNT", "NONO", "NOP10", "NOP56", "NOVA2", "NPC1", "NPC2", "NPM1", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NTHL1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDXK", "PEPD", "PEX14", "PEX19", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PHKA1", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PISD", "PITRM1", "PKN1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPP3CA", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PSPH", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QRICH1", "QRSL1", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RABL3", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RREB1", "SALL2", "SAMHD1", "SAR1B", "SARS", "SARS2", "SASS6", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SH3PXD2B", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC2A1", "SLC33A1", "SLC39A14", "SLC9A6", "SLTM", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SORL1", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SRP54", "SRP72", "SSBP1", "SSR4", "STAG1", "STAG2", "STAMBP", "STARD7", "STAT1", "STAT3", "STK4", "STT3A", "STT3B", "STUB1", "STX3", "SUCLA2", "SUCLG1", "SURF1", "SUZ12", "SYNE2", "TACO1", "TAF15", "TAF6", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TCOF1", "TDP2", "TECR", "TELO2", "TENM3", "TERF2IP", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TIMMDC1", "TJP2", "TKT", "TLK2", "TMCO1", "TMEM126A", "TMEM165", "TMEM199", "TMEM43", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOMM40", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM3", "TPP1", "TPP2", "TRAPPC11", "TRAPPC4", "TRIM28", "TRIP12", 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sha256:ce90a1981d4a52d7cda4f65e9e59401bebbd0ce34cf6376c42b4e8b9895467aa +size 139381 diff --git a/msigdb_kegg/consensus.joblib b/msigdb_kegg/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..d3b1f5e1e71dfafa3e46cabb0ca11c69fd92c559 --- /dev/null +++ b/msigdb_kegg/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b64dab7ff13a43793766db352a0daf18550acb6cf885bb03de023634b005e356 +size 70615 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3643d1496d99ebaed07d58997d365fed662bb04b --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Metabolism of xenobiotics by cytochrome p450 2 9 2.175452143926951 0.0295962506074671 2.2305825242718447 8.677184466019417 0.4162080538073979 0.4339520212351831 1.7688613666570594 0.8590827321798344 1.0192072203934597 0.2887521752792201 1.0 8.597904339497348e-05 0.000560114149758 0.00763616277579 0.0494682330743412 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..44780ad6d7def651c0965e99910452f2048c9723 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 179, + "title": "Average number of proteins per term", + "value": 16.335195530726256 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..26f517f0ecaf95a58f606b1bbd5b8dabe92b8540 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d1464dba66c029f88946a3cbc94dc501a23ee209 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,74 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metabolism of xenobiotics by cytochrome p450 0.7438981849063405 2.175452143926951 0.0295962506074671 0.9953816016449408 0.5886365398596249 9 O15217,P07099 2 +Jak stat signaling pathway 0.6467923414598035 1.70737272211828 0.0877527971303568 0.9999999275322574 1.0 9 P40763,Q92783,P22681,P31751,P31749 5 +Acute myeloid leukemia 0.6345946052922319 1.64558310904512 0.0998496190460391 0.999999993356492 1.0 11 P31751,P14923,P42345 3 +Proteasome 0.5276157311634352 1.6014470058946202 0.1092779486193933 0.999999998991085 1.0 35 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Non small cell lung cancer 0.6144989439127702 1.54462142532182 0.1224378606803626 0.9999999999297348 1.0 10 P31751,P11802 2 +Small cell lung cancer 0.6014126146355068 1.4776750435964658 0.1394947773462 0.9999999999979065 1.0 12 Q05397,P24941,P07942,P11802,P31751,P31749 6 +Fc epsilon ri signaling pathway 0.5858110623015801 1.399476808701546 0.1616700480674002 0.9999999999999803 1.0 10 P31751,P31749 2 +Drug metabolism cytochrome p450 0.5916452017175846 1.3131673850407772 0.1891265514506459 1.0 1.0 8 O15217 1 +Apoptosis 0.553076261976281 1.263569812707584 0.2063844742897087 1.0 1.0 19 P17612,O95831,P07384,P31751,Q08209,P31749 6 +Tgf beta signaling pathway 0.552890225269747 1.2365352099630864 0.2162596861812762 1.0 1.0 9 P63208,P30153,P30154 3 +Insulin signaling pathway 0.4454511047281188 1.2297807536062233 0.218779217302429 1.0 1.0 39 P17612,P62753,P41440,P22681,O14654,Q9UPT5,P31751,O00763,P49815,Q13085,P31749,P42345 12 +Cysteine and methionine metabolism 0.5505980380109564 1.2192509576562434 0.2227489563534161 1.0 1.0 15 Q13126,P26358,P52788 3 +Glycine serine and threonine metabolism 0.564881191274874 1.182695230534662 0.2369299551182986 1.0 1.0 8 P78330,P34897,P34896 3 +Selenoamino acid metabolism 0.5550065876152874 1.134528026515119 0.2565731243818736 1.0 1.0 8 P49903,Q9NZL9,Q7Z4G4,O43252,O43865,P56192,P23526 7 +Erbb signaling pathway 0.5315454049223681 1.1215976078934211 0.2620335691966078 1.0 1.0 16 Q05397,P22681,P31751,Q13555,P42345 5 +Aldosterone regulated sodium reabsorption 0.5895452290416863 1.0855679416499078 0.2776701895459545 1.0 1.0 6 Q96PU5 1 +Tight junction 0.4416109503278845 1.085308818114197 0.2777849016251084 1.0 1.0 37 P63151,Q96A65,P67870,P30153,Q9UDY2,P30154,Q16625,P55196,P11802,P61586,P11171,Q05655,P60953,P31751,Q15334,Q7Z406,P31749 17 +Hedgehog signaling pathway 0.7489821215161774 1.076976452183601 0.2814907858157636 1.0 1.0 3 P17612 1 +Ether lipid metabolism 0.6098712281582706 1.0489194349294253 0.2942151998207389 1.0 1.0 5 P68402,P43034 2 +Glioma 0.5180096393456419 1.0441795101988007 0.2964023449363799 1.0 1.0 13 P31751,P11802,Q13555,P42345 4 +Non homologous end joining 0.5774831532890752 1.0312422260642964 0.302427243515738 1.0 1.0 6 P78527 1 +Steroid biosynthesis 0.5123841068888221 1.0248411467265086 0.3054381479575583 1.0 1.0 10 Q15392,Q16850,Q9UBM7,Q14534 4 +Glutathione metabolism 0.5051495463979725 1.0072234010695749 0.3138274300057313 1.0 1.0 20 P00390,P48735,O95881,P21266,O15217,O75874 6 +Allograft rejection 0.6174342105263232 0.9604513092848738 0.336828125283771 1.0 1.0 4 P10321,P04439,P49327 3 +Graft versus host disease 0.6174342105263232 0.9604513092848738 0.336828125283771 1.0 1.0 4 P10321,P04439,P49327 3 +Autoimmune thyroid disease 0.6174342105263232 0.9604513092848738 0.336828125283771 1.0 1.0 4 P10321,P04439,P49327 3 +Endometrial cancer 0.4970296780428848 0.9375002039910832 0.3485013188795252 1.0 1.0 12 P31751,P31749,P25054 3 +Nucleotide excision repair 0.4759493142560396 0.8941650391836207 0.3712335947173448 1.0 1.0 24 Q07864,P41208,P49005,P41440,P40937,Q16531,Q9Y2S7,P35251,P18074,P19447,Q9NRF9,P40938 12 +Colorectal cancer 0.4865128422958362 0.879380812626354 0.3791948320368781 1.0 1.0 15 P31751,P61586,P31749,P52701 4 +Mismatch repair 0.4813285737962375 0.8610596877933169 0.3892051701197276 1.0 1.0 18 P49005,P41440,P40937,Q9Y2S7,P35251,Q9UQ84,P52701,P40938 8 +Pancreatic cancer 0.4796915614458912 0.8450127981805704 0.3981036934648978 1.0 1.0 16 P40763,P11802,P60953,P31751,P31749 5 +P53 signaling pathway 0.4746396840442577 0.8178877857470097 0.4134212653691054 1.0 1.0 14 P49815,P11802,O95067 3 +Base excision repair 0.4730466939336581 0.8126248254162354 0.416433193676665 1.0 1.0 17 Q07864,P49005,P18887,Q9NRF9,P27695 5 +Basal transcription factors 0.5788056002761339 0.803717572050278 0.4215601034137057 1.0 1.0 4 P29083 1 +Chronic myeloid leukemia 0.4688549642223422 0.7905153305149463 0.4292268726775878 1.0 1.0 17 P22681,P11802,P31751 3 +Olfactory transduction 0.6660502753484618 0.7719649641903905 0.4401351786312859 1.0 1.0 3 P17612 1 +Vegf signaling pathway 0.4641705002815147 0.7702069847723187 0.4411771212743169 1.0 1.0 12 Q05397,P31751,Q08209,P31749 4 +Mtor signaling pathway 0.4616057339845824 0.7535592950285595 0.4511138940342167 1.0 1.0 13 P49815,P31751,P31749,P42345 4 +Gnrh signaling pathway 0.4539626999432837 0.7244813699515598 0.4687702605949755 1.0 1.0 11 P17612,Q05655,Q13555 3 +One carbon pool by folate 0.4495507570045181 0.7174937345825044 0.4730695009974892 1.0 1.0 9 P34897 1 +Vasopressin regulated water reabsorption 0.4511358655866399 0.6982108550373473 0.4850453389216325 1.0 1.0 14 Q9UJW0 1 +Porphyrin and chlorophyll metabolism 0.4479819519616261 0.6823910600373453 0.4949917071918492 1.0 1.0 14 P06132,Q5JPH6,P30519,Q7KZN9 4 +Vibrio cholerae infection 0.4437811143062501 0.6667702878150756 0.504918874242215 1.0 1.0 19 P17612,P24390,Q93050,Q9Y487,O43731 5 +Arrhythmogenic right ventricular cardiomyopathy arvc 0.4448135530389495 0.6665654549260113 0.5050497410527379 1.0 1.0 14 P06756,P15924,P14923,P19022 4 +Regulation of actin cytoskeleton 0.3093786931914717 0.6612413519622704 0.5084575459613154 1.0 1.0 51 Q05397,Q96F07,O15144,P25054,P06756,Q9UQB8,P61586,O15511,P60953,Q7L576,Q8N8S7,Q7Z406,Q92888,P35080 14 +Melanoma 0.4385878744345016 0.6561107447820302 0.5117528715267072 1.0 1.0 10 P31751,P11802 2 +Cell cycle 0.3001067995008658 0.6402049742008104 0.5220393493713598 1.0 1.0 48 P33993,Q9H1A4,P24941,P20248,P11802,Q9UBD5,O43913,P78527,P63208,O95067 10 +Dna replication 0.412462239588728 0.6372980009137803 0.5239307528595392 1.0 1.0 30 P33993,Q07864,P49005,P41440,Q14181,P40937,Q9Y2S7,P35251,P27694,Q9NRF9,P33991,P40938 12 +Renin angiotensin system 0.5233666104956523 0.5892961127955529 0.5556626520347145 1.0 1.0 4 Q9UIQ6 1 +T cell receptor signaling pathway 0.4265690311116445 0.5753529635819138 0.5650526084512102 1.0 1.0 18 P22681,P11802,P61586,P60953,P31751,Q08209,P31749 7 +Wnt signaling pathway 0.4181653492942015 0.5705704626553685 0.5682908454998326 1.0 1.0 24 P17612,P30153,P48729,P30154,P25054,P61586,Q13555,Q08209,P63208 9 +Melanogenesis 0.4070053967280528 0.5073221649058992 0.6119287889606975 1.0 1.0 10 P17612 1 +Adipocytokine signaling pathway 0.4081384523653446 0.4848212872233339 0.6278031212156474 1.0 1.0 16 P31751,O00763,P42345,O14654 4 +Vascular smooth muscle contraction 0.4051480070555343 0.472613394982214 0.6364890241752825 1.0 1.0 15 P17612,Q05655,P60660,Q92888 4 +Biosynthesis of unsaturated fatty acids 0.3944249563553259 0.4593114504549866 0.6460105262321263 1.0 1.0 9 Q9NZ01 1 +Cell adhesion molecules cams 0.3962076842670464 0.4391531590808062 0.6605505628039892 1.0 1.0 13 Q5ZPR3 1 +O glycan biosynthesis 0.466527376914804 0.3915948355846246 0.6953576043742205 1.0 1.0 4 Q10471 1 +Ribosome 0.318843544983619 0.3880003615795456 0.6980157660231285 1.0 1.0 70 P62910,P61313,P61927,P46776,P35268,P18077,P36578,P46783,P84098,Q02543,P27635,P62241,P62701,P46778,P18124,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q07020,Q9Y3U8,P83731 25 +Pathways in cancer 0.2875090955975273 0.3801265639353146 0.7038514680199459 1.0 1.0 56 Q05397,P24941,P25054,P07942,P22681,P11802,P61586,P06756,P40763,P60953,P31751,P52701,P14923,P31749,P42345 15 +Rig i like receptor signaling pathway 0.3909133970623569 0.378694607665226 0.7049146581108785 1.0 1.0 8 Q13526,O00571,Q7Z434 3 +Ubiquitin mediated proteolysis 0.2940917571660138 0.350412388450571 0.7260292304211817 1.0 1.0 44 Q12834,P30260,P22681,Q14145,Q96PU5,Q15386,Q9H1A4,O95071,Q96J02,P63208,Q9NR09,Q15369 12 +B cell receptor signaling pathway 0.3724703599016356 0.336696419412655 0.7363457628322094 1.0 1.0 13 P31751,P31749 2 +Chemokine signaling pathway 0.3634468818867395 0.3164915107562435 0.7516294677153212 1.0 1.0 26 P17612,Q05397,P40763,Q05655,P61586,P60953,P31751,P31749 8 +Pathogenic escherichia coli infection 0.3515964222343968 0.2569369479562376 0.7972274474479535 1.0 1.0 25 P04350,O15144,Q16625,P16333,P61586,O15511,P60953,Q14247,Q92974,P07437 10 +Toll like receptor signaling pathway 0.3492276826004704 0.2405562765417359 0.8098990413519183 1.0 1.0 14 Q15750,P42224,Q13546,P31751,P31749 5 +Cytosolic dna sensing pathway 0.3398586345751374 0.2300474947054357 0.8180548638161527 1.0 1.0 10 O14802,Q7Z434 2 +Retinol metabolism 0.4799828979286364 0.2215211542188439 0.8246866670270228 1.0 1.0 3 Q8TC12 1 +Citrate cycle tca cycle 0.3263833417040111 0.1592915495598841 0.873439178229177 1.0 1.0 25 P11498,P50213,P48735 3 +Prostate cancer 0.3128428199456402 0.1106867950906842 0.911864717622662 1.0 1.0 17 P31751,P31749,P42345 3 +Gap junction 0.2912917337680851 0.0547831202864504 0.956311248265818 1.0 1.0 17 P17612 1 +Purine metabolism 0.2215038585310254 0.0390293488142988 0.9688669894644324 1.0 1.0 53 O14802,Q07864,O43252,Q14181,Q9NRF9,O43924 6 +Leukocyte transendothelial migration 0.2807328266302787 0.027371958505699 0.9781630637366074 1.0 1.0 22 Q16625,P55196,Q05397,P61586 4 +Progesterone mediated oocyte maturation 0.2663831447812715 0.0031716248369091 0.997469413752586 1.0 1.0 26 P17612,P24941,P31751,Q9H1A4,P31749,O95067 6 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..10677c72cf3443fe5aa983c9f11da3de188e66ad --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Complement and coagulation cascades", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ACVR1B", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "APP", "APRT", "AQR", "ARF6", "ARFGAP1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG4B", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BAX", "BCAS2", "BCAT1", "BCAT2", "BCL10", "BDH2", "BIRC6", "BLVRA", "BLVRB", "BPNT1", "BRCA1", "BRD8", "BUB1B", "BUB3", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CANT1", "CANX", "CAPN1", "CAPN2", "CARS", "CASP3", "CBL", "CBR1", "CCDC6", "CCNA2", "CCNB1", "CCNB2", "CD276", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDS2", "CERK", "CETN2", "CFL1", "CFL2", "CHEK1", "CHEK2", "CHERP", "CHKA", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHORDC1", "CHUK", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT4", "CNOT9", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPE", "CPOX", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CXADR", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DARS", "DARS2", "DBT", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNA2", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DPM1", "DPYSL2", "DPYSL5", "DSC2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERCC2", "ERCC3", "ERCC4", "ERO1A", "ESPL1", "EXO1", "EXOC4", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAH", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GFPT1", "GGA2", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3A", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HCCS", "HDAC1", "HDAC2", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IGF1R", "IGF2BP1", "IGF2R", "IKBKB", "ILK", "IMPDH1", "IMPDH2", "IQGAP1", "IQGAP2", "IRS4", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KDELR1", "KDELR3", "KDSR", "KEAP1", "LAMB1", "LAMC1", "LAMP1", "LAP3", "LARS", "LARS2", "LDHA", "LDHB", "LDLR", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LRP1", "LRP2", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LYN", "LYPLA1", "M6PR", "MAD2L1", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAP2K4", "MAPK1", "MAPK3", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MFSD8", "MGAT1", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPG", "MPHOSPH6", "MPI", "MPST", "MPV17", "MRE11", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVB12A", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCK1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEU1", "NF1", "NLN", "NME1", "NME2", "NME3", "NNT", "NPC1", "NPC2", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NT5C2", "NTHL1", "NUDT5", "NUDT9", "OAT", "OCLN", "OCRL", "OGDH", "ORC3", "ORC5", "OXA1L", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARN", "PARP1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PECR", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PHKA1", "PHPT1", "PI4KB", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIN1", "PISD", "PKM", "PKN1", "PLA2G15", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLXNB2", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPH", "PTDSS1", "PTDSS2", "PTGES2", "PTK2", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "RAB13", "RAB5A", "RAB5B", "RAB5C", "RABEP1", "RAC1", "RAD21", "RAD23B", "RAD50", "RALA", "RALB", "RAPGEF2", "RARS", "RARS2", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RCOR1", "RDH11", "RDX", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIPK1", "RNASEH2A", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RUVBL1", "SAE1", "SARS", "SARS2", "SART1", "SCARB2", "SCD", "SCP2", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEPHS1", "SETD1A", "SETD7", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC19A1", "SLC25A10", "SLC25A15", "SLC25A17", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC2A4", "SLC33A1", "SLC38A2", "SLC9A6", "SLIT2", "SLK", "SLTM", "SMAP1", "SMC1A", "SMC3", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP47", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORD", "SORT1", "SPCS2", "SPCS3", "SPR", "SPTAN1", "SPTLC1", "SPTLC2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SV2A", "SYMPK", "TAB1", "TAF6", "TAF6L", "TALDO1", "TAP1", "TARS", "TARS2", "TBK1", "TBL1XR1", "TCERG1", "TECR", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TOLLIP", "TOMM40", "TP53", "TPI1", "TPM3", "TPP1", "TPR", "TRA2A", "TRA2B", "TRIM21", "TRIM25", "TRIP12", "TRMT11", "TROVE2", "TSC2", "TSG101", "TSTA3", "TTC37", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TXNDC12", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBR5", "UCK2", "UGCG", "UGP2", "UMPS", "UNC45A", "UNG", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USP39", "USP8", "UXS1", "VAMP7", "VANGL1", "VAPA", "VARS1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VPS37B", "VPS45", "VPS4A", "VPS4B", "WARS", "WBP11", "WDR61", "XAB2", "XPC", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZFYVE16", "ZYX"], "leading_proteins": ["ACACA", "ACACB", "AFDN", "AHCY", "AHCYL1", "AIFM1", "AKT1", "AKT2", "ANAPC1", "APC", "APEX1", "ARHGEF1", "ARHGEF2", "ARPC2", "ARPC5", "ATP6V0A1", "ATP6V0A2", "BAIAP2", "BIRC6", "CAMK2G", "CAPN1", "CBL", "CCNA2", "CCNB2", "CD276", "CDC20", "CDC27", "CDC42", "CDH2", "CDK2", "CDK4", "CETN2", "COX15", "CSNK1A1", "CSNK2B", "CTTN", "CYFIP1", "CYFIP2", "CYP51A1", "DCTN4", "DDB1", "DDX3X", "DHCR24", "DHCR7", "DNMT1", "DSP", "EARS2", "ELOC", "ENAH", "EPB41", "EPHX1", "ERCC2", "ERCC3", "EXO1", "EXOC4", "EXOC7", "FASN", "GALNT2", "GSR", "GSTA4", 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vitamins and cofactors 13 35 2.312927459434781 0.0207266277960729 8.531553398058252 36.74271844660194 -1.2385108719406173 0.2845253733939605 3.474103155144582 4.348509440902812 1.672558535712947 0.3228771741911537 1.0 0.0732573258319426 0.0001856092270614 1.0715674842334286e-06 1.9051362815638624e-05 +The role of gtse1 in g2 m progression after g2 checkpoint 11 49 2.297912372040902 0.0215667769897547 14.79611650485437 48.84466019417476 0.6226477470486884 0.5168095546238419 7.820323564061835 1.8499922936255029 1.3076695437390702 0.3722860732713196 1.0 0.0042640190855243 0.0237780734936168 0.0189112165581134 0.003849360051379 +Clec7a dectin 1 signaling 13 48 2.286018687741322 0.0222531653068487 14.883495145631068 47.679611650485434 0.3802624296591366 0.5314258409805565 8.39359553685929 3.2641435107686965 1.369019650621671 0.3735312556615013 1.0 0.0082661149627475 0.0435948943788258 0.1326204837623513 0.0452985595419176 +Pcp ce pathway 12 47 2.208745194910386 0.027192368960957 13.383495145631068 48.61407766990291 0.2861400551198787 0.573085795011315 7.677259284018882 2.3137612538026593 1.2152839684208736 0.370148963517148 1.0 0.0065211094409693 0.0351428570214521 0.1053309619978856 0.0291925508680915 +Metabolism of steroids 14 43 2.185739504814803 0.0288346689088863 11.16019417475728 45.26699029126213 0.7621248609364072 0.3994790342082778 4.702670999060317 5.049423467032678 1.2014135082145578 0.3371477938402821 0.0398055815064507 0.0139189683537814 0.0003644305102914 0.0025613367244061 8.455325784913962e-05 +Ovarian tumor domain proteases 5 10 2.1660901980667013 0.0303042950789687 3.3009708737864076 8.611650485436893 -0.0545895007385164 0.62605422182602 2.3558848087632325 1.442981068232173 0.7775147818170627 0.2913094692521883 1.0 1.0 1.0 0.5480182958360471 0.2122751228755446 +Regulation of hmox1 expression and activity 13 45 2.1577312251002594 0.0309487347604582 12.524271844660197 45.58009708737864 0.7171016159839839 0.514573723238038 7.335701580194855 2.006274620945924 1.1938232298543638 0.3651188593292154 1.0 0.0028326312129738 0.0162472537628389 0.0443360554469674 0.0053536928586859 +Degradation of gli1 by the proteasome 12 40 2.1413802677865017 0.0322433848690757 12.514563106796116 40.61407766990291 0.5405675752115602 0.5324758124461996 7.125251251124314 1.5545410691631658 1.272200728765061 0.3678115987415289 1.0 0.0021878047045258 0.01274759481083 0.007273720853174 0.0007120315665355 +Keratinization 4 8 2.128507447022364 0.0332950331738683 2.8470873786407767 5.691747572815534 -0.6850619911507018 0.3520169434460188 1.399866936164618 1.016671637173928 1.2355195198288238 0.313798966027817 1.0 1.0 1.0 0.0171165739281897 0.0044935925611117 +Formation of the cornified envelope 4 8 2.128507447022364 0.0332950331738683 2.8470873786407767 5.691747572815534 -0.6850619911507018 0.3520169434460188 1.399866936164618 1.016671637173928 1.2355195198288238 0.313798966027817 1.0 1.0 1.0 0.0171165739281897 0.0044935925611117 +Regulation of tp53 expression and degradation 6 11 2.1257897600612305 0.0335207690343641 3.6966019417475726 10.317961165048544 0.294217562214269 0.6081549616972154 2.5840601955018023 2.0297227603613113 0.762833700222209 0.3012258595302401 1.0 0.1499686155438198 0.2637098090419308 0.5373196958667315 0.1999844382922513 +Mapk6 mapk4 signaling 12 48 2.11584374621588 0.0343580991079106 14.218446601941748 48.50728155339806 0.436374163749397 0.5681669850793678 8.12289402218768 1.923903139365317 1.248358570542089 0.3688600113322806 1.0 0.0062917946367029 0.0340121724982314 0.0322217639229287 0.0096300236825983 +Regulation of runx2 expression and activity 12 41 2.1137093567232137 0.0345400988569168 13.184466019417476 42.609223300970875 0.5014097272359687 0.5334388394290158 7.623733474716015 1.80350585730159 1.3084091861848088 0.3700608446837968 1.0 0.0032700867405931 0.0185807372115441 0.0130081192640402 0.0020000537167567 +Flt3 signaling 2 6 2.103420425586037 0.0354290345057175 1.6966019417475728 4.674757281553398 0.1447448421401304 0.5151478334177053 1.1502165717541968 0.9558423770819222 0.9684926451060778 0.307151973986046 1.0 0.1244478155008913 0.2215080089822307 0.4676212374409516 0.1307613341808224 +Scf skp2 mediated degradation of p27 p21 12 40 2.0931498196025258 0.036335782604868 12.78883495145631 40.70873786407767 0.5921499036968256 0.5162943652980111 7.12520288261254 1.2647657441579598 1.3047123749289669 0.3686628673319737 1.0 0.0023085518548632 0.0134088475923548 0.0354529720255955 0.0034206680068197 +Phase i functionalization of compounds 3 14 2.0724865555073264 0.0382200887739403 3.5364077669902914 14.184466019417476 1.0829555250605305 0.2802752482018614 1.63283502003666 1.0657744603346575 1.0337417132355466 0.2758879448139676 1.0 0.0155575631698287 0.0499872601028361 0.0120261750690007 0.10824930273491 +G1 s dna damage checkpoints 11 41 2.0317276345888944 0.0421812366936842 12.276699029126211 40.3252427184466 0.5620621733571898 0.5261130346169095 7.080750657966309 1.8659034848764728 1.2552712987328345 0.3710523646543767 1.0 0.0032700867405931 0.0185807372115441 0.0517438404893245 0.0233333674779117 +Metabolism of steroid hormones 1 6 2.0302604000714464 0.0423300771851933 2.0606796116504853 5.754854368932039 0.472180937604631 0.3480370596589613 1.2262134961449431 0.9324780265795692 1.1891708581028433 0.2889255498989442 1.0 1.0 0.0052264902137193 0.0299842123439505 0.1061326514653331 +Cyclin d associated events in g1 5 8 2.018902665866805 0.0434973371028659 4.366504854368932 10.116504854368932 0.1222182547646903 0.5717022199186504 2.5273541207987025 1.6637247419470345 0.9055693104495058 0.3101665598109623 1.0 1.0 1.0 1.0 0.6302880920877445 +Cdt1 association with the cdc6 orc origin complex 11 39 2.002460948376442 0.0452351790966405 11.8373786407767 39.713592233009706 0.7088745358379469 0.5132999135100862 6.7665841522618235 1.8864642297262784 1.2345641700762902 0.3668156388656303 1.0 0.0023085518548632 0.0134088475923548 0.0078689504463762 0.0008196874686836 +Downstream signaling events of b cell receptor bcr 12 43 1.9976976671059887 0.0457494472956867 13.109223300970871 42.81310679611651 0.5337893000107979 0.5120527765027618 7.35013455914348 2.784583610128895 1.330630298725885 0.3688632335833426 1.0 0.0050180872027471 0.0276366046790147 0.0809578044560524 0.0175501901544762 +Mitotic g1 phase and g1 s transition 24 74 1.995403165317137 0.0459989259939006 22.104368932038835 76.02184466019418 0.5927262006732629 0.5705780900762646 11.678595487596883 5.354610434747646 1.3736272695770486 0.3846948779804449 1.0 0.0051833044475417 0.0429467099251266 0.0473860420224579 0.0028476837093101 +Regulation of pten stability and activity 12 41 1.9786977781669943 0.0478500432750872 12.611650485436892 41.82281553398058 0.6486618107800725 0.5229501310802542 7.056269001912706 2.1755846965350556 1.2659780846667748 0.3745012259374719 1.0 0.0002463506370571 0.0026638903519071 0.0148133403881687 0.0025130744009218 +Transcriptional activity of smad2 smad3 smad4 heterotrimer 2 9 1.976184766385507 0.0481338545936884 3.3106796116504853 8.783980582524272 -0.2506868697377846 0.5483740500110029 2.2577982496640963 1.853738201583846 0.8482817237930166 0.2988919116057229 1.0 0.1828652209005429 0.0546703746725879 0.2436966947851946 0.3016209109703216 +Ctla4 inhibitory signaling 3 7 1.960041967222528 0.0499908852899464 2.5 6.686893203883495 0.2776426982509004 0.5315314558160165 1.6626975391802674 1.5459069221319763 0.9108905562415662 0.3127539794709458 1.0 0.0802348466038066 0.1457909390967105 0.3274785952656331 0.1881865161038274 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f55b4d23b9a8e544b7d691b6399548139361231a --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 1393, + "title": "Average number of proteins per term", + "value": 18.87221823402728 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a2efa7c01057a48f3c2ec922e63a8e257beeb254 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9fee0d16a9e00a1b1fa0fe1e8b57af16ca974aa2 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,486 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transcriptional regulation by runx2 0.5491731753552674 2.9906860866008524 0.0027835147419128 0.9794077918664856 0.6219070664947132 51 P25786,Q14997,O00231,P28070,P11802,P42224,P49721,Q13951,P31751,P28074,P20618,Q99436,P60900,P31749,P63208 15 +Orc1 removal from chromatin 0.5397362471239209 2.95743148873883 0.0031021367790262 0.9868059990017982 0.6219070664947132 49 P25786,Q14997,O00231,P33993,P28070,P24941,P20248,P49721,Q99436,P28074,P20618,O43913,Q9UBD5,P60900,P63208 15 +Hedgehog off state 0.5367567277538281 2.9301685700239117 0.0033877816986596 0.991148707469664 0.6219070664947132 49 P17612,P04350,P25786,O00231,Q14997,P28070,P48729,P60900,P49721,Q99436,P28074,P20618,Q96J02,P63208 14 +Biotin transport and metabolism 0.9443732399596896 2.91417090090124 0.0035663461070933 0.9931039045683212 0.6219070664947132 8 P11498,P05165,Q96RQ3,O00763,P50747 5 +Defects in biotin btn metabolism 0.9406810291927106 2.750620686758567 0.0059482475918004 0.9997541159255762 0.6219070664947132 7 P11498,P50747,Q96RQ3,P05165 4 +Degradation of beta catenin by the destruction complex 0.5255497840512042 2.7048653644384246 0.006833207845331 0.9999288932954948 0.6219070664947132 47 P25786,Q14997,O00231,P28070,P30153,P30154,P48729,P25054,P49721,Q99436,P28074,P20618,P60900,P63208 14 +Switching of origins to a post replicative state 0.5235126817960908 2.6251785635090714 0.0086603536418385 0.9999945310006974 0.6219070664947132 56 P25786,Q14997,O00231,P33993,P28070,P24941,P20248,P49721,Q96DE5,Q99436,P28074,P20618,O43913,Q9UBD5,Q9H1A4,P60900,P63208 17 +Uch proteinases 0.5732296476312237 2.6034440000782273 0.0092292343740305 0.9999975416448464 0.6219070664947132 43 P28074,Q8NB78,P28070,P49721 4 +Defects in vitamin and cofactor metabolism 0.8221103188594361 2.5594224915462047 0.0104846233018778 0.9999995796524852 0.6219070664947132 12 P11498,P05165,Q96RQ3,O14678,P50747 5 +Regulation of tp53 activity 0.4983997996908349 2.5462343032194195 0.0108892071886868 0.9999997622051394 0.6219070664947132 50 O14744,P30153,Q9NRG4,P30154,P24941,P40937,P20248,Q92804,Q12873,Q92547,O94776,P31751,Q9UQ84,Q9NPI1,Q13526,P31749,P42345 17 +Biological oxidations 0.5911547136464986 2.532046227416057 0.0113399039981603 0.9999998739685688 0.6219070664947132 41 P07099,Q8WUX2,Q86WA6,Q9NUJ1,Q06520,O15217,P21266,P30837,Q16850 9 +Signaling by the b cell receptor bcr 0.5062676217805853 2.529010125713948 0.0114384727145464 0.9999998903116366 0.6219070664947132 47 P25786,Q14997,O00231,P28070,P16333,O43865,P49721,Q99436,P28074,P20618,P62942,P60900,Q08209,P63208 14 +Cyclin a cdk2 associated events at s phase entry 0.5757773106170275 2.515012009427026 0.0119028329166044 0.9999999429943058 0.6219070664947132 42 P25786,O00231,P28070,P24941,P20248,P11802,P49721,P31751,P28074,P20618,Q99436,P60900,P31749,P63208 14 +Metabolism of vitamins and cofactors 0.5142294486592504 2.4666576171643975 0.0136380691673352 0.999999995073156 0.6219070664947132 46 P11498,P05165,P41440,P34897,Q96RQ3,O75874,Q4G0N4,O00763,O14678,Q9NVE7,Q13085,P50747,Q9NRN7,P43490 14 +Signaling by hedgehog 0.497014356560233 2.427923879475892 0.0151855301061638 0.9999999994470212 0.6219070664947132 54 P17612,P04350,P25786,O00231,Q14997,P28070,P48729,P60900,P49721,Q99436,P28074,P20618,Q96J02,P63208 14 +Beta catenin independent wnt signaling 0.4832736856152373 2.4020811790994805 0.0163020902665163 0.9999999998861284 0.6219070664947132 50 P25786,Q14997,O00231,P28070,P61586,Q96CW1,P49721,Q99436,P28074,P20618,P60900,Q08209,Q9HCE1 13 +Apc c mediated degradation of cell cycle proteins 0.4889200161363231 2.3248959835555683 0.0200775228030425 0.9999999999994628 0.6219070664947132 55 P25786,Q14997,O00231,Q12834,P28070,P24941,P20248,P49721,Q96DE5,Q99436,P28074,P20618,Q9H1A4,P60900,P63208 15 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4980006706725312 2.3207353757390705 0.0203011302239877 0.9999999999996092 0.6219070664947132 46 P25786,Q14997,O00231,Q12834,P28070,P49721,Q96DE5,Q99436,P28074,P20618,Q9H1A4,P60900 12 +Metabolism of water soluble vitamins and cofactors 0.6301544711643453 2.3129274594347815 0.0207266277960729 0.9999999999997866 0.6219070664947132 35 P11498,P05165,P41440,P34897,Q96RQ3,O00763,O14678,Q4G0N4,Q9NVE7,Q13085,P50747,Q9NRN7,P43490 13 +The role of gtse1 in g2 m progression after g2 checkpoint 0.4696993103667572 2.297912372040902 0.0215667769897547 0.9999999999999356 0.6219070664947132 49 P25786,P04350,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,O95067 11 +Clec7a dectin 1 signaling 0.4657088219441511 2.286018687741322 0.0222531653068487 0.9999999999999756 0.6219070664947132 48 P25786,Q14997,O00231,P28070,O43865,Q05655,P49721,Q99436,P28074,P20618,P60900,Q08209,P63208 13 +Pcp ce pathway 0.4718999655728556 2.208745194910386 0.027192368960957 1.0 0.6219070664947132 47 P25786,Q14997,O00231,P28070,P28066,P61586,Q96CW1,P49721,Q99436,P28074,P20618,P60900 12 +Metabolism of steroids 0.5222207538404893 2.185739504814803 0.0288346689088863 1.0 0.6219070664947132 43 Q14739,Q15392,O95487,P37268,Q86X55,O95772,P53992,P22059,O00763,Q14534,Q13085,Q16850,Q9UBM7,Q14849 14 +Ovarian tumor domain proteases 0.7413134075004072 2.1660901980667013 0.0303042950789687 1.0 0.6219070664947132 10 P25054,P61586,Q6GQQ9,Q96FW1,Q7Z434 5 +Regulation of hmox1 expression and activity 0.4933595148578208 2.1577312251002594 0.0309487347604582 1.0 0.6219070664947132 45 P67870,P25786,Q14997,O00231,P28070,Q05655,P28066,P49721,Q99436,P28074,P20618,P60900,P63208 13 +Degradation of gli1 by the proteasome 0.5524614608583444 2.1413802677865017 0.0322433848690757 1.0 0.6219070664947132 40 P17612,P25786,Q14997,O00231,P28070,P60900,P49721,Q99436,P28074,P20618,Q96J02,P63208 12 +Keratinization 0.7638531855180934 2.128507447022364 0.0332950331738683 1.0 0.6219070664947132 8 Q08554,P15924,P14923,Q14574 4 +Formation of the cornified envelope 0.7638531855180934 2.128507447022364 0.0332950331738683 1.0 0.6219070664947132 8 Q08554,P15924,P14923,Q14574 4 +Regulation of tp53 expression and degradation 0.7319547585516264 2.1257897600612305 0.0335207690343641 1.0 0.6219070664947132 11 P30153,P24941,P30154,P31751,P31749,P42345 6 +Mapk6 mapk4 signaling 0.4483183752267116 2.1158437462158797 0.0343580991079106 1.0 0.6219070664947132 48 P17612,P25786,Q14997,O00231,P28070,P49721,P60953,Q99436,P28074,P20618,P60900,Q9HCE1 12 +Regulation of runx2 expression and activity 0.5374548442858599 2.1137093567232137 0.0345400988569168 1.0 0.6219070664947132 41 P25786,Q14997,O00231,P28070,P42224,P49721,Q13951,Q99436,P28074,P20618,P60900,P63208 12 +Carnitine metabolism 0.8953947368421092 2.106024868121891 0.0352021922561265 1.0 0.6219070664947132 4 Q13085,O00763,O43772 3 +Flt3 signaling 0.8190208481003026 2.103420425586037 0.0354290345057175 1.0 0.6219070664947132 6 P22681,P31751 2 +Scf skp2 mediated degradation of p27 p21 0.5462140596873716 2.0931498196025258 0.036335782604868 1.0 0.6219070664947132 40 P25786,O00231,P28070,P24941,P20248,P11802,P49721,Q99436,P28074,P20618,P60900,P63208 12 +Phase i functionalization of compounds 0.7163484769658934 2.0724865555073264 0.0382200887739403 1.0 0.6265444965955261 14 Q16850,P07099,P30837 3 +Pregnenolone biosynthesis 0.8799692322381767 2.0444343222008716 0.040910659519223 1.0 0.6272957182869607 4 Q14849 1 +G1 s dna damage checkpoints 0.5271462704035491 2.0317276345888944 0.0421812366936842 1.0 0.6272957182869607 41 P25786,Q14997,O00231,P28070,P24941,P20248,P49721,Q99436,P28074,P20618,P60900 11 +Metabolism of steroid hormones 0.8019275277162647 2.0302604000714464 0.0423300771851933 1.0 0.6272957182869607 6 Q14849 1 +Cyclin d associated events in g1 0.7399540198414682 2.018902665866805 0.0434973371028659 1.0 0.6378083219399188 8 P30153,P24941,P30154,P11802,P63208 5 +Cdt1 association with the cdc6 orc origin complex 0.5452433488371632 2.002460948376442 0.0452351790966405 1.0 0.6466880457241764 39 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,O43913,Q9UBD5,P60900 11 +Downstream signaling events of b cell receptor bcr 0.4998232706654374 1.9976976671059892 0.0457494472956867 1.0 0.6466880457241764 43 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P62942,P60900,Q08209,P63208 12 +Mitotic g1 phase and g1 s transition 0.5034662378173853 1.995403165317137 0.0459989259939006 1.0 0.6466880457241764 74 P63151,O00231,P33993,P24941,P30154,P49721,P28074,P20618,Q07864,P28070,P30153,Q14181,P31751,P63208,P25786,P20248,P11802,Q99436,O43913,P60900,P31749,P00374,Q9UBD5,Q9NRF9 24 +Regulation of pten stability and activity 0.520511299887394 1.9786977781669943 0.0478500432750872 1.0 0.6466880457241764 41 P25786,Q14997,O00231,P28070,P28066,P49721,P31751,P28074,P20618,Q99436,P60900,P31749 12 +Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.7019825700372087 1.976184766385507 0.0481338545936884 1.0 0.6466880457241764 9 Q96PU5,P50750 2 +Ctla4 inhibitory signaling 0.7562392712664887 1.960041967222528 0.0499908852899464 1.0 0.6466880457241764 7 P31751,P31749,P30154 3 +Synthesis of pc 0.8210052981406826 1.95603446334794 0.0504610944272796 1.0 0.6466880457241764 5 P35790 1 +Hedgehog on state 0.5281364483165893 1.9525891264176816 0.0508683006420533 1.0 0.6466880457241764 40 P25786,Q14997,O00231,P28070,P48729,P60900,P49721,Q99436,P28074,P20618,Q96J02 11 +Ras processing 0.8189603237641825 1.947486195532783 0.0514764731583072 1.0 0.6466880457241764 5 O43924,O60725,P49356 3 +Cilium assembly 0.4466778889444385 1.941256864334275 0.0522271288455011 1.0 0.6466880457241764 54 P17612,P04350,Q96A65,O95684,P30153,P41208,A6NIH7,P43034,A0AVF1,Q15154,Q9UPT5,O43924,Q92538,Q9NQ48 14 +C type lectin receptors clrs 0.4410523121255733 1.9379592301626096 0.0526281967629032 1.0 0.6466880457241764 52 P17612,P25786,Q14997,O00231,P28070,O43865,Q05655,P49721,Q99436,P28074,P20618,P60900,Q08209,P63208 14 +Transcriptional regulation by runx3 0.524217470057768 1.921930385135422 0.0546145178900427 1.0 0.6557598820420479 40 Q13951,P28074,P28070,P49721 4 +Constitutive signaling by akt1 e17k in cancer 0.7436750274458799 1.90360846312711 0.0569611957839826 1.0 0.6557598820420479 7 P49815,P31751,P42345 3 +Negative regulation of notch4 signaling 0.5210783490752734 1.8973268903309068 0.0577848080922824 1.0 0.6597888333815533 40 P25786,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,P31749,P63208 10 +Regulation of ras by gaps 0.5383943057833636 1.8741913442737457 0.0609040567320757 1.0 0.6793368341722492 38 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P21359,P60900 10 +Dectin 1 mediated noncanonical nf kb signaling 0.5070191232629964 1.8702612137945125 0.0614475528397009 1.0 0.6793368341722492 41 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,P63208 10 +Tnfr2 non canonical nf kb pathway 0.5070191232629964 1.8702612137945125 0.0614475528397009 1.0 0.6793368341722492 41 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,P63208 10 +Regulation of tp53 activity through acetylation 0.6759794531417916 1.8616354639597144 0.0626544909147726 1.0 0.6800492389680978 13 Q12873,P31751,Q9NPI1,Q13526,P31749 5 +Apoptotic cleavage of cell adhesion proteins 0.7263074857542093 1.825094017576838 0.0679868428211978 1.0 0.6926306550667851 7 Q16625,P15924 2 +Translesion synthesis by polk 0.6650677130630052 1.7971578271073452 0.0723105675383533 1.0 0.6926306550667851 9 P35251,P40937,P40938,P41440 4 +Regulation of runx3 expression and activity 0.545925894075531 1.7924508142029874 0.0730607813185684 1.0 0.6926306550667851 36 Q13951,P28074,P28070,P49721 4 +Interleukin 1 signaling 0.4144371174283485 1.7784368168965807 0.075332140426821 1.0 0.6926306550667851 48 P25786,Q14997,O00231,P28070,Q15750,P28066,P49721,Q99436,P28074,P20618,P60900,P63208,Q15008 13 +Metabolism of folate and pterines 0.6868893614781308 1.7710440941680423 0.076553369515842 1.0 0.6926306550667851 8 P34897,P34896,Q9H2D1,P41440 4 +Pi3k akt signaling in cancer 0.6566721924033978 1.763874306179241 0.0777531435922358 1.0 0.6926306550667851 13 P49815,P31751,O43815,P42345 4 +Cholesterol biosynthesis 0.6536813843080266 1.763326492596378 0.077845439568015 1.0 0.6926306550667851 15 Q15392,Q14739,P37268,Q14534,Q16850,Q9UBM7 6 +Metabolism of polyamines 0.522462253731688 1.7546092306531262 0.0793261714783788 1.0 0.6926306550667851 38 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,P52788 10 +Signaling by pdgfr in disease 0.7648138121160605 1.7187974644334445 0.0856512573966119 1.0 0.6926306550667851 5 P40763,O43815 2 +Assembly and cell surface presentation of nmda receptors 0.6434055532496841 1.6894316412415544 0.0911367416310704 1.0 0.6926306550667851 10 Q14168,P04350,Q13555 3 +Cyclin a b1 b2 associated events during g2 m transition 0.6432164586193755 1.688975296153467 0.0912241642266176 1.0 0.6926306550667851 11 P63151,P30153,P20248,P24941,P30154,O95067 6 +Stabilization of p53 0.5134038047645598 1.6862540443487848 0.0917468784285471 1.0 0.6926306550667851 38 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Interleukin 6 family signaling 0.7904234145822686 1.680207787305424 0.0929168947420544 1.0 0.6926306550667851 4 P22681,P40763 2 +Interleukin 6 signaling 0.7904234145822686 1.680207787305424 0.0929168947420544 1.0 0.6926306550667851 4 P22681,P40763 2 +E2f enabled inhibition of pre replication complex formation 0.7546357707078627 1.6753416434404222 0.0938672192641978 1.0 0.6926306550667851 5 Q9UBD5 1 +Tcr signaling 0.4164136678331029 1.6753081324969288 0.0938737906449085 1.0 0.6926306550667851 47 P25786,Q14997,O00231,P28070,P16333,P28066,P49721,Q99436,P28074,P20618,P60900,P63208 12 +Synthesis of dna 0.4912291418690436 1.6752850139920197 0.0938783243192262 1.0 0.6926306550667851 83 O00231,P33993,P24941,P49005,Q9Y248,P28066,P49721,Q9Y2S7,P28074,P20618,Q07864,P28070,P30260,P41440,Q14181,P40937,Q96DE5,Q9H1A4,P63208,P25786,Q14997,P20248,P35251,Q99436,P27694,Q14691,O43913,P60900,Q9BRT9,Q9UBD5,Q9NRF9,P33991,P40938,Q15008 34 +Cellular response to hypoxia 0.5012361281363692 1.6645950298041308 0.095993577625046 1.0 0.6926306550667851 39 P25786,Q14997,O00231,P28070,P28066,P49721,Q99436,P28074,P20618,P60900 10 +Negative regulation of nmda receptor mediated neuronal transmission 0.7167786227544302 1.6580333362493425 0.0973107379243176 1.0 0.6926306550667851 6 Q14168,Q13555 2 +Akt phosphorylates targets in the cytosol 0.716620922571652 1.6573329869608198 0.097452171636919 1.0 0.6926306550667851 6 P49815,P31751 2 +Disassembly of the destruction complex and recruitment of axin to the membrane 0.7164986098054495 1.656789769055632 0.0975619861833767 1.0 0.6926306550667851 6 P30154,P30153,P48729 3 +Beta catenin phosphorylation cascade 0.7164986098054495 1.656789769055632 0.0975619861833767 1.0 0.6926306550667851 6 P48729,P30153,P30154 3 +Signaling by ctnnb1 phospho site mutants 0.7164986098054495 1.656789769055632 0.0975619861833767 1.0 0.6926306550667851 6 P48729,P30153,P30154 3 +Estrogen dependent nuclear events downstream of esr membrane signaling 0.6893308970050829 1.656090498574038 0.0977034932061677 1.0 0.6926306550667851 7 Q05397,P31751 2 +Abc transporter disorders 0.4801748032683456 1.6524148312499396 0.0984500141444533 1.0 0.6926306550667851 41 P28074,P28070,O14678,P49721 4 +Signaling by notch4 0.4694840675516641 1.6484983228044077 0.0992504545843879 1.0 0.6947531820907158 42 P25786,P28070,P49721,P28074,P20618,P63208 6 +Darpp 32 events 0.6335361217129807 1.6418004588213022 0.1006313639534477 1.0 0.6948616778421655 9 P17612,Q08209,P30153,P30154 4 +Runx1 regulates expression of components of tight junctions 0.897784458846224 1.6412037860958284 0.1007551200701364 1.0 0.6948616778421655 3 Q16625 1 +Cytosolic sulfonation of small molecules 0.7129833566655424 1.6411685815507318 0.100762425645454 1.0 0.6948616778421655 6 Q06520 1 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.7803283469051778 1.6385161548568454 0.1013140668701531 1.0 0.6952241140400162 4 P17612,P30154 2 +Regulation of mecp2 expression and activity 0.6322232051700343 1.6336048687626044 0.1023418448537976 1.0 0.6982473426486431 10 P17612,Q14739,P42858,Q13555,Q9HCE1 5 +Fceri mediated nf kb activation 0.4461983744522884 1.631534593893551 0.1027775665139538 1.0 0.6982473426486431 44 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900,P63208 10 +Trafficking of ampa receptors 0.6551600945720458 1.62010543455389 0.105209630219444 1.0 0.6982473426486431 8 Q13555,Q96CW1 2 +Asymmetric localization of pcp proteins 0.5130205467729629 1.6164613820946108 0.1059945963747328 1.0 0.6982473426486431 37 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Tcf dependent signaling in response to wnt 0.4291196493080025 1.6162223710584276 0.1060462436710296 1.0 0.6982473426486431 60 O00231,P30154,P28066,P49721,P28074,P20618,P67870,P28070,P30153,P48729,P31751,P25786,Q14997,P25054,Q99436,P60900,P31749,Q9Y4A5,Q9UBL3,O14980 20 +Long term potentiation 0.7406014751414793 1.6152067594932291 0.1062659272372665 1.0 0.6982473426486431 5 Q14168,Q13555 2 +Ras activation upon ca2 influx through nmda receptor 0.7406014751414793 1.6152067594932291 0.1062659272372665 1.0 0.6982473426486431 5 Q14168,Q13555 2 +Unblocking of nmda receptors glutamate binding and activation 0.7406014751414793 1.6152067594932291 0.1062659272372665 1.0 0.6982473426486431 5 Q14168,Q13555 2 +Degradation of dvl 0.5119323006161811 1.6083961180933088 0.1077484513212885 1.0 0.7006139768656038 37 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Degradation of axin 0.5202470224012238 1.6071182016360093 0.108028441205745 1.0 0.7006139768656038 36 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Cd28 dependent pi3k akt signaling 0.8858927984215652 1.5962528209304503 0.1104323588581919 1.0 0.7006139768656038 3 P31751,P42345 2 +Runx2 regulates genes involved in cell migration 0.8858927984215654 1.5962528209304503 0.1104323588581919 1.0 0.7006139768656038 3 Q13951,P31751 2 +Translesion synthesis by polh 0.6225063669672741 1.5858226755888236 0.1127795403298252 1.0 0.7053994842191704 12 P41440,P40937,P35251,Q92890,P27694,P40938 6 +Recognition of dna damage by pcna containing replication complex 0.6129158231776508 1.568346701353306 0.1168002424798846 1.0 0.7136084990108741 17 Q07864,P49005,P41440,P40937,Q16531,P35251,Q9Y2S7,Q9NRF9,P40938 9 +Neddylation 0.4337127331768683 1.5393631173926572 0.1237156729364268 1.0 0.7333443931933726 65 P25786,Q14997,O00231,P28070,Q14145,P28066,Q99627,Q92564,P49721,Q9UNS2,Q99436,P28074,P20618,Q7L5N1,Q9BT78,P60900,P63208 17 +Fc epsilon receptor fceri signaling 0.4033932808987103 1.5368822671918598 0.1243221427118062 1.0 0.7338167152438391 53 P25786,Q14997,O00231,P28070,O43865,P49721,Q99436,P28074,P20618,P60900,Q08209,P63208 12 +Pcna dependent long patch base excision repair 0.6030429093626384 1.5267464439296226 0.1268240736455652 1.0 0.7348708377614213 18 Q07864,P49005,P41440,P40937,P35251,Q9Y2S7,Q9NRF9,P40938,P27695 9 +Metabolism of porphyrins 0.6085723767652972 1.5173869469298706 0.1291690175734765 1.0 0.7348708377614213 9 P06132,P30519 2 +Hedgehog ligand biogenesis 0.4821473677909615 1.5162054439856056 0.1294674119319785 1.0 0.7348708377614213 39 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Cross presentation of soluble exogenous antigens endosomes 0.4983452636806635 1.507495672242765 0.1316836523177793 1.0 0.7348708377614213 37 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Auf1 hnrnp d0 binds and destabilizes mrna 0.4623519689521602 1.506605548650568 0.1319117943170291 1.0 0.7348708377614213 41 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Insulin processing 0.6311366286558311 1.5046506670592148 0.1324139126188921 1.0 0.7348708377614213 8 Q96A65,Q8NEW0 2 +Regulation of tp53 activity through association with co factors 0.8604983719611896 1.4999963521766786 0.1336153474549133 1.0 0.7359570745568851 3 P31751 1 +Antigen processing cross presentation 0.3970789112018988 1.499114635562253 0.1338438954091645 1.0 0.7359570745568851 52 P28074,P20618,P28070,P49721 4 +Heme biosynthesis 0.7116755909034924 1.4905753289696748 0.1360730255702464 1.0 0.7359570745568851 5 P06132 1 +Regulation of runx1 expression and activity 0.857781725674212 1.489681828646501 0.1363079147420505 1.0 0.7359570745568851 3 Q13951 1 +Gap filling dna repair synthesis and ligation in gg ner 0.5953369678541035 1.484707939806169 0.1376212075556742 1.0 0.7401789271237612 18 Q07864,P49005,P41440,P40937,P35251,Q9Y2S7,P18887,Q9NRF9,P40938 9 +Cargo trafficking to the periciliary membrane 0.595881480188259 1.476531277900403 0.1398013249868928 1.0 0.7490124834874679 17 Q96A65,A6NIH7,O43924,Q92538,Q9NQ48 5 +Downregulation of smad2 3 smad4 transcriptional activity 0.6734688041453766 1.4644701737697927 0.1430655267197416 1.0 0.7562880663079603 6 Q96PU5 1 +Downregulation of erbb2 erbb3 signaling 0.8509776518869316 1.4638370158154554 0.143238485917543 1.0 0.7562880663079603 3 P31751 1 +Cytoprotection by hmox1 0.4247032667674526 1.4514811422113765 0.1466459295841282 1.0 0.7562880663079603 65 O00231,P30519,P28066,Q86X55,P49721,Q15526,P28074,P20618,Q9BSH4,P67870,P28070,P63208,P25786,Q14997,Q15648,Q99436,P60900,Q96ST3,P40763,Q05655,P53004 21 +Chrebp activates metabolic gene expression 0.6992698235802619 1.436888740989049 0.1507496095998166 1.0 0.7562880663079603 5 O00763 1 +Dna replication pre initiation 0.4133800615767884 1.412525027978055 0.1577954266615546 1.0 0.7562880663079603 62 P25786,Q14997,O00231,P33993,Q07864,P24941,P28070,Q14181,P49721,Q99436,P28074,P20618,O43913,Q9UBD5,Q9NRF9,P60900 16 +Signaling by vegf 0.5343054167433964 1.412131453003028 0.1579112591066169 1.0 0.7562880663079603 30 P17612,Q05397,Q96F07,P06756,O43865,Q05655,Q9UQB8,P61586,P60953,P31751,Q7L576,P14923,P31749,P42345 14 +Vldlr internalisation and degradation 0.6362649132234631 1.40985603697148 0.1585821961936746 1.0 0.7562880663079603 7 P98155,Q96CW1 2 +Antigen processing ubiquitination proteasome degradation 0.4716843821075313 1.4050608640964408 0.1600031803551995 1.0 0.7562880663079603 87 Q92990,O00231,P28066,P49721,Q5T4S7,P28074,P20618,Q9UIQ6,Q96J02,P55786,Q13867,P29144,P28070,Q14145,Q9H1A4,P63208,P25786,Q14997,Q96PU5,Q15386,O94822,Q99436,P60900,O95376,Q12834,P52888,Q5VTB9,Q9Y4B6 28 +Assembly of the hiv virion 0.8329496876027549 1.3953021806936812 0.1629247347594247 1.0 0.7562880663079603 3 Q9H9H4,Q96EY5 2 +E2f mediated regulation of dna replication 0.5852270871499946 1.3945467678932588 0.16315255704612 1.0 0.7562880663079603 11 Q9UBD5,P30154,O43913,Q14181 4 +Stat3 nuclear events downstream of alk signaling 0.7215774495048517 1.3941222457809022 0.1632806925580321 1.0 0.7562880663079603 4 Q96ST3 1 +Signaling by alk 0.7215774495048517 1.3941222457809022 0.1632806925580321 1.0 0.7562880663079603 4 Q96ST3 1 +Erks are inactivated 0.6301592906755044 1.381311922107819 0.1671830740572106 1.0 0.7590142106127262 7 P30153,Q8IV63,P30154 3 +Negative regulation of the pi3k akt network 0.5824256164371779 1.381005205474202 0.1672773601278585 1.0 0.7590142106127262 13 P31751,P31749,O43815,P30154 4 +Dag and ip3 signaling 0.6280921754802826 1.3716406938420689 0.1701753190532473 1.0 0.7667226796402298 7 P17612,O43865,Q13555 3 +Signaling by cytosolic fgfr1 fusion mutants 0.6471275094539299 1.3457911215219636 0.1783698895493044 1.0 0.7848917553858296 6 O95684,P40763,P42224 3 +Activation of bh3 only proteins 0.5752339849910532 1.345680349262416 0.1784056264107967 1.0 0.7848917553858296 10 P31751 1 +Interleukin 1 family signaling 0.3786674715400326 1.3392686966879934 0.1804832155394407 1.0 0.7848917553858296 51 P25786,Q14997,O00231,P28070,Q15750,P40763,P28066,P49721,Q99436,P28074,P20618,P60900,P63208,Q15008 14 +G beta gamma signalling through pi3kgamma 0.8178230845116625 1.337769996705248 0.1809714252429421 1.0 0.7848917553858296 3 P31751,P31749 2 +Ub specific processing proteases 0.4225157069528716 1.3364922451278458 0.1813884335388467 1.0 0.7848917553858296 69 O00231,Q93008,P28066,P49721,Q92890,P28074,P20618,P28070,Q14145,Q96K76,Q93009,P25786,Q14997,Q9NZL9,P20248,Q99436,P60900,Q9Y4A5,Q12834,Q96RU2,Q9UPU5,Q15750,Q13546,Q96FW1,Q15008 25 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.4414879025115203 1.3353282670357811 0.1817689309571859 1.0 0.7848917553858296 41 P25786,Q14997,O00231,P28070,P60900,P49721,Q13951,Q99436,P28074,P20618,Q96J02 11 +Dcc mediated attractive signaling 0.7068857535967575 1.3327048918973556 0.1826286672811949 1.0 0.7848917553858296 4 Q05397,P60953 2 +Activation of bad and translocation to mitochondria 0.5955582530072965 1.3322113389340011 0.1827907515723303 1.0 0.7848917553858296 8 P31751 1 +Integrin signaling 0.6438966725664882 1.3312017742274609 0.1831226277820492 1.0 0.7848917553858296 6 Q05397 1 +Platelet aggregation plug formation 0.6438966725664882 1.3312017742274609 0.1831226277820492 1.0 0.7848917553858296 6 Q05397 1 +Cdc6 association with the orc origin complex 0.8140708332354787 1.323500147834607 0.1856691071617038 1.0 0.7909390406001633 3 Q9UBD5 1 +Sphingolipid de novo biosynthesis 0.5696177195191673 1.3170674402511986 0.1878160197742202 1.0 0.7910399861601676 10 Q96G23,P27544,Q06136,O15270,P22059 5 +Defective cftr causes cystic fibrosis 0.4477018303312661 1.3138634811986751 0.1888921500403821 1.0 0.7910399861601676 40 P25786,Q14997,O00231,P28070,P49721,Q99436,P28074,P20618,P60900 9 +Peptide hormone metabolism 0.5695413881923101 1.3137409616081963 0.1889333913926496 1.0 0.7910399861601676 13 Q96A65,Q8NEW0,Q9UPT5 3 +S phase 0.4775158772330498 1.3135405788195385 0.1890008566050085 1.0 0.7910399861601676 94 O00231,P33993,P24941,P49005,Q9Y248,P28066,P49721,Q9Y2S7,P28074,P20618,Q7Z5K2,Q07864,P28070,P30260,P41440,Q14181,P40937,Q96DE5,P31751,Q9H1A4,P63208,P25786,Q14997,P20248,P11802,P35251,Q99436,P27694,Q14691,O43913,P60900,P31749,Q9BRT9,Q9UBD5,Q9NRF9,P33991,P40938,Q15008 38 +Circadian clock 0.5685857209409994 1.3118066279792042 0.189585388033832 1.0 0.7910399861601676 10 P43490,P63208,Q86X55,Q9BWF3 4 +Vitamin b5 pantothenate metabolism 0.8069679602263559 1.2964937105923529 0.1948054454864585 1.0 0.800483733223117 3 Q9NRN7 1 +Recycling of eif2 gdp 0.609292812683519 1.283548380444908 0.1993000211095223 1.0 0.8141493530954976 7 Q13144,Q9NR50,Q14232,Q9UI10,P49770 5 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.5488813844837039 1.266956012515876 0.2051710187499122 1.0 0.8212736468926086 21 Q07864,P49005,P41440,P40937,Q9Y2S7,P35251,Q9NRF9,P40938,P27695 9 +Signaling by scf kit 0.5799177477418759 1.256032210107462 0.20910429215544 1.0 0.8283277919688147 8 P40763,P22681 2 +Diseases of mitotic cell cycle 0.5562330584020352 1.253481954107805 0.2100303624655455 1.0 0.8288166994745181 9 Q96DE5,P11802,P24941,Q9H1A4 4 +Activation of gene expression by srebf srebp 0.5537508510894052 1.241113542601624 0.2145638073757265 1.0 0.8321077841554071 16 P37268,O00763,Q14534,Q13085,Q16850,Q9UBM7 6 +Phase ii conjugation of compounds 0.5262536006972235 1.2353303994031255 0.2167075643955547 1.0 0.8321077841554071 26 Q8WUX2,O43252,P21266,Q06520,O15217,Q9NUJ1 6 +Flt3 signaling in disease 0.6226074047713038 1.2349675110306697 0.2168425958102116 1.0 0.8321077841554071 6 P22681,Q14789 2 +Abc family proteins mediated transport 0.3713674118410597 1.233861725471896 0.2172544338741757 1.0 0.8321077841554071 47 P25786,Q14997,P28070,P49721,P28074,P20618,P40855 7 +Deubiquitination 0.455492403541241 1.2332177970129814 0.2174945172149707 1.0 0.8321077841554071 88 Q8NB78,O00231,P28066,P49721,Q92890,P28074,P20618,P28070,P61586,Q96K76,P25786,Q14997,P20248,P25054,Q99436,Q7Z434,P60900,Q9Y4A5,Q12834,Q96RU2,Q9UPU5,Q92783,Q6GQQ9,Q13546,Q96FW1,Q99496 26 +Pkmts methylate histone lysines 0.5465870275185851 1.2172987572991043 0.2234905669579958 1.0 0.8403737113085532 18 Q9H7B4 1 +Hdr through homologous recombination hrr 0.5341836284503888 1.2164379779299257 0.2238181241173533 1.0 0.8403737113085532 23 Q07864,P49005,P41440,P40937,Q92547,Q9Y2S7,P35251,P27694,Q9UQ84,Q9NRF9,P40938 11 +Interleukin 20 family signaling 0.7838421730985845 1.2086752747760878 0.2267876243303903 1.0 0.8416917645793289 3 P40763 1 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.5447183685687191 1.195086822623804 0.2320531098890907 1.0 0.8462041415589097 9 Q9HA64,Q9BU89 2 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.5668544354397407 1.1923214374336109 0.2331352319043138 1.0 0.8478102204462115 8 Q86X55 1 +Global genome nucleotide excision repair gg ner 0.4463780866340106 1.1762574882272383 0.2394919981178898 1.0 0.8488863953644288 38 Q07864,P41208,P49005,P41440,P40937,Q16531,Q99627,Q9Y2S7,P35251,P18074,Q7L5N1,P19447,Q9BT78,P18887,Q9UNS2,Q9NRF9,P40938 17 +Resolution of abasic sites ap sites 0.5158702480428885 1.1721234185650802 0.2411475089461612 1.0 0.8505471052119395 26 Q07864,P49005,P41440,P40937,Q9Y2S7,P35251,P18887,Q9NRF9,P40938,P27695 10 +Mitotic g2 g2 m phases 0.4511023445890249 1.1720382519291916 0.2411816988935506 1.0 0.8505471052119395 89 P63151,P04350,O00231,P24941,P30154,P28066,P49721,Q15154,Q96CW5,P28074,P20618,O95067,P17612,P28070,P30153,P41208,P43034,P63208,P25786,Q14997,O75935,P20248,Q99436,P60900,O95684 25 +Transcriptional regulation by mecp2 0.5418992591249796 1.1701533368536845 0.2419392674740601 1.0 0.8507703011644961 14 P17612,Q14739,P42858,Q13555,Q9HCE1 5 +Dna replication 0.448845539699601 1.1512485095974034 0.2496300135750764 1.0 0.8667066360972439 89 O00231,P33993,P24941,P49005,Q9Y248,P28066,P49721,Q9Y2S7,P28074,P20618,Q07864,P28070,P30260,P41440,Q14181,P40937,Q96DE5,Q9H1A4,P63208,P25786,Q14997,O60684,P20248,P35251,Q99436,P27694,Q14691,O43913,P60900,Q9BRT9,Q9UBD5,Q9NRF9,P33991,P40938,Q15008 35 +Ca dependent events 0.5802113061440741 1.147043628235276 0.2513635900813256 1.0 0.8667066360972439 7 P17612,Q13555 2 +Regulation of localization of foxo transcription factors 0.6007401167411996 1.1361025686435529 0.2559136401506758 1.0 0.8731250186960913 6 P31751 1 +Opioid signalling 0.5321840638583715 1.130695459666063 0.2581832930147612 1.0 0.8731250186960913 17 P17612,P30153,P30154,O43865,Q05655,Q13555,Q08209 7 +Role of phospholipids in phagocytosis 0.7604669169631216 1.1202370324978204 0.2626127668687861 1.0 0.8793740005966804 3 O43865 1 +Fceri mediated ca 2 mobilization 0.6555393842404746 1.1181923351498897 0.2634848571905281 1.0 0.8801784318139226 4 O43865 1 +Fcgr3a mediated il10 synthesis 0.6243535609790929 1.1115758224278027 0.2663205726953463 1.0 0.8862900040789676 5 P17612 1 +Regulation of cholesterol biosynthesis by srebp srebf 0.5160969452857795 1.1109569704752909 0.26658687129152 1.0 0.8862900040789676 23 O95487,P37268,P53992,O00763,Q14534,Q13085,Q16850,Q9UBM7 8 +Pten regulation 0.3889931610202154 1.1045555508169511 0.26935222031477 1.0 0.8891176372001769 65 P25786,Q14997,O00231,P28070,Q12873,P28066,P49721,O94776,P31751,P28074,P20618,Q99436,Q99496,P42345,P60900,P31749,Q9HCE1 17 +Regulation of plk1 activity at g2 m transition 0.4424001994634353 1.0911462268302174 0.2752085447838936 1.0 0.896219055741289 37 P17612,P04350,Q7Z460,O95684,O75935,P30153,P41208,P43034,Q7Z4H7,Q68CZ6,Q15691,Q15154,P07437,P63208,P53350,O95067 16 +Vxpx cargo targeting to cilium 0.5904974466334119 1.0898627242654286 0.2757736187597719 1.0 0.896219055741289 6 Q96A65,Q92538,Q9UPT5,Q96KP1 4 +Maturation of sars cov 2 nucleoprotein 0.6186294605669533 1.0867850118745377 0.2771318331518038 1.0 0.896219055741289 5 P78362,P48729 2 +Dna replication initiation 0.5668872380827953 1.0845599245860245 0.2781166126483168 1.0 0.896219055741289 7 Q9NRF9,Q14181 2 +Regulation of beta cell development 0.7485163583120371 1.0752253513882066 0.2822738479032671 1.0 0.9018519957092916 3 P31751 1 +Post chaperonin tubulin folding pathway 0.521325771386141 1.0704397142133155 0.2844214311672397 1.0 0.9052315408470843 10 P04350,Q15813 2 +Rho gtpases activate cit 0.5204319955812029 1.0658785511909332 0.2864785460174146 1.0 0.9052315408470843 10 Q15334,O43663,P60660,P61586 4 +Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.7459937055331651 1.06574598542952 0.2865384839510057 1.0 0.9052315408470843 3 P24941 1 +Glutathione conjugation 0.5218719019354596 1.0643445894105212 0.2871726254419786 1.0 0.9052315408470843 13 O15217,Q8WUX2,P21266 3 +Polymerase switching 0.5218219115103353 1.0642163924001409 0.2872306827382709 1.0 0.9052315408470843 14 P49005,P41440,Q14181,P40937,Q9Y2S7,P40938 6 +Costimulation by the cd28 family 0.5199016992872642 1.0541020512571382 0.2918361971462442 1.0 0.9121755073155704 14 P30153,P30154,P31751,P31749,P42345 5 +Nicotinate metabolism 0.7399902002843772 1.0432215852469318 0.2968456785969486 1.0 0.9121755073155704 3 P43490 1 +Pp2a mediated dephosphorylation of key metabolic factors 0.7388849061947216 1.0390803151730357 0.2987673850688281 1.0 0.9122670167517756 3 P30154 1 +Ion homeostasis 0.5133473768160604 1.036000577728836 0.3002018729905269 1.0 0.9122670167517756 9 P17612,Q13555 2 +Cardiac conduction 0.5133473768160604 1.036000577728836 0.3002018729905269 1.0 0.9122670167517756 9 P17612,Q13555 2 +Endosomal vacuolar pathway 0.6355359466553725 1.0351164336504328 0.3006145387533552 1.0 0.9122670167517756 4 P10321,Q9UIQ6 2 +Polymerase switching on the c strand of the telomere 0.5135823990687891 1.0221950312412678 0.306688602015809 1.0 0.9172548731068728 15 P49005,P41440,Q14181,P40937,Q9Y2S7,P40938 6 +Mismatch repair 0.511142317976528 1.0136463228868422 0.3107515454996306 1.0 0.9172548731068728 11 Q9Y2S7,Q9UQ84,P49005,P52701 4 +Oncogene induced senescence 0.6002545299726783 1.0074565569986025 0.3137154243705959 1.0 0.9172548731068728 5 P11802 1 +Interleukin 2 family signaling 0.7301903455587675 1.006570532392041 0.3141412011560245 1.0 0.9172548731068728 3 P40763 1 +Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.7301903455587675 1.006570532392041 0.3141412011560245 1.0 0.9172548731068728 3 P40763 1 +Lagging strand synthesis 0.5059295793184746 1.0020663366199292 0.3163115550779114 1.0 0.9175610729191158 19 P49005,Q14181,P41440,P40937,Q9Y2S7,P35251,P27694,P40938 8 +Tgf beta receptor signaling activates smads 0.5078765842934883 1.0018885642567756 0.3163974163702976 1.0 0.9175610729191158 10 P22681,P62942,Q96PU5,Q9Y3F4 4 +Signaling by wnt in cancer 0.5268608397565997 0.997530429033301 0.3185071113399396 1.0 0.9175610729191158 8 P30154,P30153,P48729 3 +Fgfr1 mutant receptor activation 0.5267446385727603 0.996966547911746 0.3187807476325275 1.0 0.9175610729191158 8 O95684,P40763,O95429 3 +Signaling by fgfr1 in disease 0.5267446385727603 0.996966547911746 0.3187807476325275 1.0 0.9175610729191158 8 O95684,P40763,O95429 3 +Signaling by csf3 g csf 0.5255368521392602 0.9911067880923746 0.3216334387427788 1.0 0.92378428900761 8 P40763,P42224 2 +Cd28 co stimulation 0.502634437433453 0.981834668192378 0.3261813057785119 1.0 0.9260899151701384 9 P31751,P31749,P42345 3 +Hur elavl1 binds and stabilizes mrna 0.5655013038674139 0.977463091773047 0.3283399413278949 1.0 0.9260899151701384 6 Q05655,Q01105 2 +Telomere c strand lagging strand synthesis 0.4988028673355935 0.9718592514315688 0.331120574106873 1.0 0.9260899151701384 20 P49005,Q14181,P41440,P40937,Q9Y2S7,P35251,P27694,P40938 8 +Dna damage recognition in gg ner 0.5038554122359122 0.9706770348080928 0.3317091313496405 1.0 0.9260899151701384 15 P41208,Q16531,O96019,Q13098,Q01831,Q92905,Q99627,Q7L5N1,Q9BT78,Q9UNS2 10 +Egfr downregulation 0.5638407508318406 0.9700281141663488 0.3320324786627795 1.0 0.9260899151701384 6 P22681,Q92783 2 +Foxo mediated transcription 0.5024482898090805 0.9691104754157522 0.3324900716577958 1.0 0.9260899151701384 11 P31751,P31749 2 +Signaling by erbb2 0.5030744651283734 0.9686169869503248 0.3327363247082333 1.0 0.9260899151701384 12 P31751,Q05655,P31749 3 +Inactivation of csf3 g csf signaling 0.5614378597863956 0.9592782861198812 0.3374185711900916 1.0 0.9260899151701384 6 P40763,P42224 2 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.5612637527301401 0.9584998045770148 0.337810789982147 1.0 0.9260899151701384 6 Q16850 1 +G protein mediated events 0.5001477670585679 0.9573476889138712 0.3383917924060304 1.0 0.9260899151701384 11 P17612,O43865,Q13555 3 +Vegfr2 mediated vascular permeability 0.4984849021762185 0.9488517727514416 0.3426960058772699 1.0 0.9320927589211578 11 P31751,P14923,P42345 3 +Retrograde neurotrophin signalling 0.5375000666040823 0.9473758719959382 0.3434472814249556 1.0 0.9320927589211578 7 Q00610,Q96CW1 2 +Downregulation of erbb2 signaling 0.513106425987699 0.9309423690605042 0.3518833762732498 1.0 0.9320927589211578 8 P31751 1 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.6090099971920866 0.9259260554749648 0.3544844095437991 1.0 0.9320927589211578 4 O43865 1 +Ca2 pathway 0.7074422405299601 0.9221708634551572 0.356439458441586 1.0 0.9320927589211578 3 Q9HCE1 1 +Intracellular signaling by second messengers 0.414636238138385 0.9195505110434842 0.3578076984084668 1.0 0.9320927589211578 85 O00231,P30154,P28066,P49721,P28074,P20618,Q9HCE1,P17612,P30153,P28070,P31751,P25786,Q14997,Q12873,Q99436,P60900,P31749,O43865,Q05655,O43815,O94776,Q99496,P49815,Q13555,P42345 25 +Signaling by kit in disease 0.6068202068230143 0.9169786864995052 0.3591538088153529 1.0 0.9320927589211578 4 P40763 1 +Signaling by fgfr4 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Negative regulation of fgfr1 signaling 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Negative regulation of fgfr2 signaling 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Negative regulation of fgfr3 signaling 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Spry regulation of fgf signaling 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Negative regulation of fgfr4 signaling 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Signaling by fgfr1 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Signaling by fgfr3 0.5518857642013767 0.916660148734707 0.3593207548748469 1.0 0.9320927589211578 6 P22681 1 +Termination of translesion dna synthesis 0.4893521722253451 0.9043293884966286 0.3658207678627012 1.0 0.9330234295129568 18 Q07864,P49005,P41440,P40937,P35251,Q9Y2S7,Q9NRF9,P40938 8 +Interleukin 12 family signaling 0.4555111918241156 0.90327969517946 0.3663774701676865 1.0 0.9330234295129568 30 Q53EL6,Q13126,P40763,P52597,Q99439,P60953,P22626,O14979,P14174,Q00169 10 +Transport of bile salts and organic acids metal ions and amine compounds 0.6026139304463154 0.8998259960646926 0.3682128577053747 1.0 0.934281440407262 4 Q8NEW0 1 +Displacement of dna glycosylase by apex1 0.6009868421052735 0.8932033964966829 0.371748259537104 1.0 0.9415369555185198 4 P78549,P29372,P27695 3 +Recruitment of mitotic centrosome proteins and complexes 0.4381015787329076 0.8863809212290178 0.3754122965514297 1.0 0.9439410161317338 33 P17612,P04350,Q7Z460,Q9BSJ2,O75935,P30153,P41208,O95684,P43034,Q7Z4H7,Q68CZ6,Q15691,Q15154,Q96CW5,O94927,P07437,P53350 17 +Bmal1 clock npas2 activates circadian gene expression 0.5987547050098778 0.8841299019531795 0.3766260931776886 1.0 0.9439410161317338 4 P43490,Q86X55 2 +Small interfering rna sirna biogenesis 0.5982791354157126 0.8821985413522695 0.3776694506176996 1.0 0.9439410161317338 4 Q9UPY3 1 +Serine biosynthesis 0.598067647079797 0.8813398609377644 0.3781338974026726 1.0 0.9439410161317338 4 Q9NRX5 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5026106008558151 0.8803952009613181 0.3786452553786148 1.0 0.9439410161317338 8 Q12834,P30260,Q96DE5,Q9H1A4,Q9UJX2 5 +Dna damage bypass 0.4759123484348936 0.8788662954315595 0.3794737753293402 1.0 0.9439410161317338 23 Q07864,P49005,P41440,P40937,Q16531,Q9Y2S7,Q92890,P35251,P27694,Q9NRF9,P40938 11 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4696801377292025 0.8745725299539775 0.3818065399274006 1.0 0.94637043091713 25 Q53EL6,Q13126,P52597,Q99439,P22626,O14979,P14174,Q00169 8 +Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.5684604838314814 0.8716187439709845 0.3834164016631365 1.0 0.9486661589995544 5 Q7Z434 1 +Anchoring of the basal body to the plasma membrane 0.4438016806866639 0.8580335068535803 0.3908739617332726 1.0 0.9582144418793818 31 P17612,P04350,Q7Z460,O95684,O75935,P30153,P41208,P43034,Q7Z4H7,Q68CZ6,Q15691,Q15154,Q15019,O94927,P07437,P53350 16 +Cellular response to chemical stress 0.3871714780166221 0.8511964161194809 0.3946602533160064 1.0 0.9615669891439188 76 O00231,P30519,P28066,Q86X55,P49721,Q15526,P28074,P20618,Q9BSH4,P67870,P00390,P28070,P63208,P25786,Q14997,Q15648,Q99436,P60900,Q96ST3,P40763,Q05655,P53004 22 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.4739772488527011 0.8439346409737393 0.3987059293924155 1.0 0.9659084515541476 21 Q07864,P49005,P41440,P40937,Q9Y2S7,Q92890,P35251,P27694,Q9NRF9,P40938 10 +Apc c cdc20 mediated degradation of cyclin b 0.4757471377040695 0.8394189984064879 0.4012342264094279 1.0 0.9700255707223308 10 Q9UJX3,Q12834,P30260,Q96DE5,Q9H1A4,Q9UJX2 6 +Interleukin 12 signaling 0.4566415253565685 0.8360388881942392 0.4031330260726071 1.0 0.9700255707223308 27 Q53EL6,Q13126,P52597,Q99439,P22626,O14979,P14174,Q00169 8 +Met activates ptk2 signaling 0.5591871915572744 0.8324891977010506 0.4051328730288253 1.0 0.9709943939075176 5 Q05397 1 +Dna strand elongation 0.4438011943318751 0.8294158104959033 0.4068691580249535 1.0 0.9721590688314928 30 P33993,Q9BRT9,P49005,P41440,Q9Y248,P40937,Q14181,Q9Y2S7,P35251,P27694,Q14691,P33991,P40938 13 +Tnfr1 induced nfkappab signaling pathway 0.5313200417398325 0.8256816281260352 0.4089847166588085 1.0 0.975540599838562 6 Q6GQQ9,Q13546 2 +Signaling by wnt 0.3946345739508739 0.8189246224711763 0.4128294208162557 1.0 0.9830280054650328 81 O00231,P30154,P28066,P49721,P28074,P20618,Q08209,Q9HCE1,P67870,P28070,P30153,P48729,P61586,P31751,P63208,P25786,Q14997,Q00610,P25054,Q96CW1,Q99436,P60900,P31749,Q9Y4A5,Q9UBL3,O14980 26 +Regulation of mrna stability by proteins that bind au rich elements 0.3490049975098676 0.8134786893989955 0.4159436596526347 1.0 0.9870690253766952 61 P25786,Q14997,O00231,P28070,Q05655,P28066,P49721,Q99436,P28074,P20618,P60900,Q01105,P31749 13 +Extension of telomeres 0.4386868230178229 0.797451948809006 0.4251885990748032 1.0 0.9976311893636748 30 P24941,Q14181,P41440,P49005,P40937,P20248,Q9Y2S7,P35251,P27694,O00743,Q9NPE3,P40938 12 +Phosphorylation of emi1 0.576876831361889 0.7960152541387363 0.4260231692118772 1.0 0.9976311893636748 4 Q12834,P53350 2 +Rho gtpases activate wasps and waves 0.4663579111815357 0.7932337194855035 0.427641665174628 1.0 0.9976311893636748 20 Q05397,Q96F07,P16333,Q9UQB8,O15511,P60953,Q7L576 7 +Phosphorylation of the apc c 0.4664030375054989 0.7927262995464863 0.4279373041223142 1.0 0.9976311893636748 10 Q9UJX3,P30260,Q96DE5,Q9H1A4,Q9UJX2,P53350 6 +Signaling by nuclear receptors 0.3369849511648905 0.787853572294359 0.4307823607611101 1.0 0.9978121200871848 57 Q05397,Q8NB78,P50750,Q86X55,O43815,Q13951,P31751,O14646,Q15120,P31749,Q9HCE1 11 +Glutathione synthesis and recycling 0.5747089773137478 0.7873750450879223 0.4310623506695235 1.0 0.9978121200871848 4 Q8WUX2 1 +Signaling by tgf beta receptor complex 0.4652007287617571 0.7869518987456697 0.4313100247179295 1.0 0.9978121200871848 20 Q9Y3F4,P22681,Q96PU5,P61586,P50750,O14980,Q9UPN9,P62942 8 +G0 and early g1 0.5217135323036015 0.7836452712249053 0.4332482840775753 1.0 0.9978121200871848 6 P24941 1 +Regulation of gene expression in beta cells 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 0.9978121200871848 2 P31751 1 +Akt phosphorylates targets in the nucleus 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 0.9978121200871848 2 P31751 1 +Ptk6 regulates rtks and their effectors akt1 and dok1 0.8856015779092683 0.7810096647411731 0.4347968104041071 1.0 0.9978121200871848 2 P22681 1 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.5460156561676326 0.7774139410730668 0.4369145900187643 1.0 1.0 5 P31751 1 +Epha mediated growth cone collapse 0.4804360139183765 0.7746807232054181 0.4385283444576724 1.0 1.0 8 Q7Z406,P60660,P61586 3 +Dual incision in gg ner 0.459195880526875 0.7724724834991837 0.4398346381309548 1.0 1.0 22 Q07864,P49005,P41440,P40937,Q16531,Q9Y2S7,P35251,P18074,P19447,Q9NRF9,P40938 11 +G protein beta gamma signalling 0.5430588995734611 0.7651421452667064 0.4441869059496368 1.0 1.0 5 P31751,P61586,P31749 3 +Synthesis of pa 0.51468956841128 0.7531355183079327 0.4513684827085016 1.0 1.0 6 Q9NPH0 1 +Homologous dna pairing and strand exchange 0.4618104855233219 0.7522041415700913 0.4519283034063224 1.0 1.0 14 P40937,Q92547,P27694,Q9UQ84,P40938 5 +Deactivation of the beta catenin transactivating complex 0.4571496083318761 0.7468379102345991 0.4551614088074034 1.0 1.0 10 P31751,Q9UBL3,P31749,P25054 4 +Regulation of lipid metabolism by pparalpha 0.4575277595994954 0.7454992044052874 0.4559699919291256 1.0 1.0 20 P23786,Q15067,Q96ST3,P37268,O75448,Q86X55,Q93074,Q06520,Q15648,Q9NVC6,P48163 11 +Class i peroxisomal membrane protein import 0.4728874862450022 0.7391255258345039 0.459830778162885 1.0 1.0 8 O75381,O43808,P40855 3 +Negative regulation of met activity 0.4920310844437264 0.7390538221681922 0.4598743157115952 1.0 1.0 7 P22681 1 +Heme degradation 0.5613706171287045 0.7346361437599308 0.4625611195481363 1.0 1.0 4 P30519 1 +Mapk family signaling cascades 0.3964324697517704 0.7212535468565796 0.4707535319969094 1.0 1.0 87 O00231,P30154,P49721,P28074,P20618,Q9HCE1,P17612,P30153,P28070,P21359,P36404,O43924,Q05397,P25786,O60725,Q14997,P60953,Q99436,Q15334,Q14168,P60900,P49356,Q13555 23 +Inlb mediated entry of listeria monocytogenes into host cell 0.5321249960428163 0.7200908946269925 0.4714690333388196 1.0 1.0 5 P22681 1 +Copi independent golgi to er retrograde traffic 0.4365362765619383 0.7170763935087785 0.473326960779713 1.0 1.0 27 P68402,P04350,Q9NZ32,O75935,Q9UJW0,P43034,O43237,Q10471 8 +Signaling by insulin receptor 0.4526321483131565 0.7057383792088191 0.4803508490148545 1.0 1.0 14 P31751 1 +Rab regulation of trafficking 0.4094157448197059 0.6984448989839895 0.484899005659452 1.0 1.0 33 P31751,P61026,Q15276,P49815,P62820,P31749,Q4KMP7 7 +Nucleotide excision repair 0.3097654326277756 0.6862814105614128 0.4925356690673239 1.0 1.0 50 Q07864,P41208,P49005,P41440,P40937,Q16531,Q99627,Q9Y2S7,Q93009,P35251,P18074,Q7L5N1,P19447,Q9BT78,P18887,Q9UNS2,Q9NRF9,P40938 18 +Gpvi mediated activation cascade 0.5220874698512119 0.6792382123155111 0.4969869389714623 1.0 1.0 5 P61586 1 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.4782397631897244 0.6774927277927394 0.4980933825673248 1.0 1.0 7 Q96DE5,P30260,Q9UJX2,Q9H1A4 4 +Intraflagellar transport 0.440655739702628 0.6743214140586961 0.5001069926349997 1.0 1.0 9 A0AVF1 1 +Tbc rabgaps 0.4456346521821595 0.6736303590653098 0.5005463469988829 1.0 1.0 13 P49815,Q4KMP7 2 +Alpha oxidation of phytanate 0.5423985650040559 0.6610588872071418 0.5085745497057559 1.0 1.0 4 O43808,P51648 2 +Budding and maturation of hiv virion 0.4421375634193789 0.6607243914341512 0.5087890785085163 1.0 1.0 12 Q96PU5,Q9H9H4 2 +Sema4d induced cell migration and growth cone collapse 0.4923064159992102 0.6574497596234182 0.5108917652898284 1.0 1.0 6 P60660,P61586 2 +Interleukin 3 interleukin 5 and gm csf signaling 0.4736931922496221 0.6574244965133457 0.510908004717471 1.0 1.0 7 P17612 1 +Nephrin family interactions 0.4550563352214647 0.6562731237440094 0.5116484069960432 1.0 1.0 8 P16333,Q96J84 2 +Signaling by ptk6 0.4421715281660235 0.6534226495940728 0.5134838409220475 1.0 1.0 14 P24941,P22681,P40763,P11802,P61586,Q07666,P31749 7 +Processive synthesis on the c strand of the telomere 0.4365868608473446 0.646454111112435 0.5179853065793352 1.0 1.0 10 Q9Y2S7,P27694,P49005 3 +Inhibition of replication initiation of damaged dna by rb1 e2f1 0.4896842180621955 0.6464169851922863 0.5180093433452271 1.0 1.0 6 P30154,Q14181 2 +Netrin 1 signaling 0.4331378445986372 0.6382035043946017 0.5233412162992321 1.0 1.0 9 Q05397,P60953,O94813,Q00169 4 +Vegfr2 mediated cell proliferation 0.8389217619986848 0.6363707854121272 0.5245347778757046 1.0 1.0 2 O43865 1 +Recruitment of numa to mitotic centrosomes 0.3839036215491931 0.632295177055217 0.5271940144881064 1.0 1.0 36 P17612,P04350,Q7Z460,Q9BSJ2,O75935,P30153,P41208,O95684,P43034,Q7Z4H7,Q68CZ6,Q15691,Q15154,Q96CW5,P07437,P53350 16 +Aurka activation by tpx2 0.3986356190512152 0.6301316562033745 0.5286084496322967 1.0 1.0 33 P17612,P04350,Q7Z460,O95684,O75935,P30153,P41208,P43034,Q7Z4H7,Q68CZ6,Q15691,Q15154,O75330,O94927,P07437,P53350 16 +Rho gtpases activate nadph oxidases 0.5087727712029443 0.6259041478282332 0.5313778137589069 1.0 1.0 5 Q13526 1 +Metabolism of cofactors 0.508223215200386 0.6237258019650368 0.532807675079312 1.0 1.0 5 O75874,P31749 2 +Signaling by flt3 fusion proteins 0.5304369962471409 0.6156904009517842 0.5380988738502792 1.0 1.0 4 Q14789 1 +Transcription coupled nucleotide excision repair tc ner 0.3441454203347023 0.6147973659175211 0.5386885490762348 1.0 1.0 42 Q07864,P49005,P41440,P40937,Q16531,Q99627,Q9Y2S7,Q93009,P35251,P18074,Q7L5N1,P19447,Q9BT78,P18887,Q9UNS2,Q9NRF9,P40938 17 +Zinc transporters 0.8310322156476155 0.6128475457124967 0.5399771495311765 1.0 1.0 2 Q8NEW0 1 +Metal ion slc transporters 0.8310322156476155 0.6128475457124967 0.5399771495311765 1.0 1.0 2 Q8NEW0 1 +Extra nuclear estrogen signaling 0.4343024795729783 0.6125286136292941 0.540188072602902 1.0 1.0 15 Q05397,P31751 2 +Ptk6 regulates cell cycle 0.8300460223537103 0.609928311856106 0.5419092969356194 1.0 1.0 2 P11802 1 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.8300460223537103 0.609928311856106 0.5419092969356194 1.0 1.0 2 P11802 1 +Listeria monocytogenes entry into host cells 0.4623257425127648 0.6078117048495281 0.54331236529594 1.0 1.0 7 P22681 1 +Parasite infection 0.4219553867143333 0.6029970413998702 0.5465106574150973 1.0 1.0 25 Q05397,Q96F07,P16333,Q9UQB8,O15511,P60953,Q7L576 7 +G2 m checkpoints 0.3689297586869099 0.5976028105969796 0.550104988421694 1.0 1.0 81 O00231,P33993,P24941,P28066,P49721,P28074,P20618,Q9UQ84,O95067,P28070,O96028,P40937,Q92547,P25786,Q14997,Q99436,O43913,P60900,Q9UBD5,P33991,P40938 21 +Translocation of slc2a4 glut4 to the plasma membrane 0.3972249549415739 0.5941453181003474 0.552414922508367 1.0 1.0 32 P04350,Q96A65,P31751,P61026,Q9UIQ6,P31749 6 +Clec7a dectin 1 induces nfat activation 0.8228139381985524 0.5886692985397527 0.5560831369379693 1.0 1.0 2 O43865 1 +Calcineurin activates nfat 0.8228139381985526 0.5886692985397527 0.5560831369379693 1.0 1.0 2 P62942 1 +Apoptosis 0.3800915800533004 0.5848231270694497 0.5586666520399892 1.0 1.0 87 O00231,Q16625,P49721,P28074,P20618,P28070,P15924,Q07021,P31751,Q05397,P25786,Q14997,Q9UDY2,P25054,Q99436,P10412,P60900,P31749,P40763,Q05655,Q13546 21 +Activation of atr in response to replication stress 0.4269478837278233 0.5802269278943084 0.5617615967995262 1.0 1.0 19 P33993,P24941,P40937,P27694,Q9UBD5,O43913,P33991,P40938 8 +Activation of the pre replicative complex 0.4243724501381679 0.5771998892982363 0.563804431841108 1.0 1.0 21 P33993,Q07864,Q14181,Q9UBD5,O43913,Q9NRF9 6 +Rrna processing in the mitochondrion 0.5197988480337363 0.5761056802740975 0.5645437522706422 1.0 1.0 4 Q9BQ52 1 +Trna processing in the mitochondrion 0.5197988480337363 0.5761056802740975 0.5645437522706422 1.0 1.0 4 Q9BQ52 1 +Cytosolic iron sulfur cluster assembly 0.4696509594143885 0.5636026513406136 0.5730245820253925 1.0 1.0 6 P18074,Q9Y5Y2 2 +Inactivation of cdc42 and rac1 0.6019075662900967 0.5529039946113953 0.5803291519722711 1.0 1.0 3 P60953 1 +Interferon alpha beta signaling 0.4149712889149759 0.552598086504971 0.5805386525588541 1.0 1.0 9 P10321,P42224,Q9Y3Z3 3 +G2 phase 0.8090072320841539 0.5488442263929855 0.583112356325957 1.0 1.0 2 P24941 1 +Rna polymerase iii chain elongation 0.487220343657983 0.5420235630495169 0.5878022736325157 1.0 1.0 5 O14802 1 +Rna polymerase iii transcription initiation from type 3 promoter 0.487220343657983 0.5420235630495169 0.5878022736325157 1.0 1.0 5 O14802 1 +Nuclear receptor transcription pathway 0.8057199211045529 0.5395164035785068 0.5895305814714684 1.0 1.0 2 Q9UHY1 1 +Rna polymerase iii transcription termination 0.4636832186517636 0.5394959914937136 0.5895446621324738 1.0 1.0 6 O14802 1 +Ros and rns production in phagocytes 0.4288537290432212 0.5382757456362548 0.5903866934885904 1.0 1.0 8 Q93050,Q9Y487 2 +Caspase activation via extrinsic apoptotic signalling pathway 0.5942124301216605 0.5281812671813024 0.5973735299663048 1.0 1.0 3 Q13546,P49327 2 +Interleukin 21 signaling 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 1.0 2 P40763 1 +Interleukin 9 signaling 0.7968441814595668 0.5146428325256334 0.6068026283034385 1.0 1.0 2 P40763 1 +Tnfr1 induced proapoptotic signaling 0.7948717948718047 0.509178755388187 0.6106269328712961 1.0 1.0 2 Q6GQQ9 1 +Base excision repair 0.3930081777838133 0.5051011405945182 0.6134878003051356 1.0 1.0 29 Q07864,P49005,P41440,P40937,Q9Y2S7,P35251,P18887,Q9NRF9,P40938,P27695 10 +Kinesins 0.4117061543212161 0.5043529107782262 0.614013402223258 1.0 1.0 19 P04350,Q86Y91,Q96Q89,Q9BW19,Q02241 5 +Tnf signaling 0.4008829040579217 0.4881700714350219 0.6254293815589671 1.0 1.0 9 Q6GQQ9,Q13546,O95429 3 +Transcriptional regulation of white adipocyte differentiation 0.4067270828651574 0.4869803491035022 0.6262722568679071 1.0 1.0 13 P11802,O75448,Q86X55,Q93074,Q15648,Q9NPJ6,Q9NVC6 7 +Mtor signalling 0.406281343404163 0.4760973093171064 0.6340050538295225 1.0 1.0 16 P62753,P31751,P49815,P31749,P42345 5 +Hiv transcription initiation 0.4013279218804798 0.4740084635789474 0.6354938718333851 1.0 1.0 11 P18074,Q92804,P29083 3 +Endosomal sorting complex required for transport escrt 0.3941091645598837 0.441693305547766 0.658711154653747 1.0 1.0 11 Q92783,Q9H9H4,Q96EY5 3 +Met promotes cell motility 0.3899538346804466 0.4396056162052936 0.6602227723568741 1.0 1.0 9 Q05397 1 +Class i mhc mediated antigen processing presentation 0.4077501429326536 0.4268845252932522 0.6694634372604811 1.0 1.0 111 Q92990,O00231,P28066,P49721,Q5T4S7,P28074,P20618,Q9UIQ6,Q96J02,P55786,Q13867,P29144,P28070,Q14145,O95487,Q9NZ08,Q9H1A4,P63208,Q15369,P25786,Q14997,Q96PU5,Q15386,O94822,Q99436,P60900,O95376,Q12834,P06756,P52888,P53992,Q5VTB9,Q9Y4B6 33 +Glycerophospholipid biosynthesis 0.385996940555094 0.4252710735043492 0.6706390779483309 1.0 1.0 26 Q9NQZ5,Q99829,Q9NPH0,P35790 4 +Cdc42 gtpase cycle 0.380383230009975 0.4216488321763404 0.6732813575194578 1.0 1.0 28 Q68EM7,Q14739,Q9UQB8 3 +Chromatin modifying enzymes 0.3252153888227942 0.4198358187515814 0.674605396394488 1.0 1.0 71 Q9H7B4,Q8NB78,Q12824,Q9NRG4,Q12873,O14497,Q9H9T3,Q9Y6J9,Q9Y4A5 9 +Interaction between l1 and ankyrins 0.5577872949257248 0.4170824532918843 0.6766180988605393 1.0 1.0 3 Q12955 1 +Signaling by tgfb family members 0.3903488276385993 0.4137228092664514 0.6790771206116948 1.0 1.0 22 Q9Y3F4,P22681,Q96PU5,P61586,P50750,O14980,Q9UPN9,P62942 8 +Anti inflammatory response favouring leishmania parasite infection 0.3859621446119883 0.4135801124216471 0.6791816404919166 1.0 1.0 10 P17612 1 +Carboxyterminal post translational modifications of tubulin 0.430723152787778 0.4120960297071102 0.6802690386322316 1.0 1.0 6 P04350 1 +Leishmania infection 0.3434013327008083 0.4079027436729551 0.6833450783762622 1.0 1.0 37 P17612,Q05397,Q96F07,Q9UQB8,O15511,Q7L576 6 +Intrinsic pathway for apoptosis 0.3899493378851645 0.4001028621500885 0.6890807562211847 1.0 1.0 18 Q07021,P31751,P31749 3 +Rho gtpases activate ktn1 0.4270231293349399 0.3984899791746155 0.6902690434729477 1.0 1.0 6 P60953,P61586 2 +Wax and plasmalogen biosynthesis 0.4682797384196111 0.39723432893884 0.6911946694853679 1.0 1.0 4 O00116 1 +Regulation of tp53 activity through phosphorylation 0.3697384698925275 0.3966750647894747 0.6916070902169116 1.0 1.0 30 P67870,P24941,P20248,P40937,Q92804,Q00535,Q92547,P27694,Q9UQ84,Q13526,P40938 11 +Ptk6 regulates proteins involved in rna processing 0.7508218277448986 0.3937550976576088 0.6937618585751024 1.0 1.0 2 Q07666 1 +O linked glycosylation of mucins 0.466527376914804 0.3915948355846246 0.6953576043742205 1.0 1.0 4 Q10471 1 +O linked glycosylation 0.4665273769148039 0.3915948355846243 0.6953576043742207 1.0 1.0 4 Q10471 1 +Telomere extension by telomerase 0.3813264589712618 0.3860706626414413 0.6994443364914356 1.0 1.0 11 P20248,O00743,P24941 3 +Unwinding of dna 0.3805811945482609 0.3828956606011501 0.7017971289750355 1.0 1.0 11 Q14691,Q9BRT9,Q9Y248 3 +Homology directed repair 0.327376797514844 0.3734132944992015 0.7088408663478876 1.0 1.0 39 Q07864,P24941,P49005,P41440,O96028,P40937,P20248,Q92547,Q9Y2S7,P35251,P27694,Q9UQ84,P18887,Q9NRF9,P40938 15 +Interleukin 27 signaling 0.5422693455734622 0.37313271804004 0.7090496687886525 1.0 1.0 3 P40763 1 +Interleukin 35 signalling 0.5422693455734622 0.37313271804004 0.7090496687886525 1.0 1.0 3 P40763 1 +Rab gefs exchange gtp for gdp on rabs 0.3771794901943313 0.3721039891300535 0.7098154263666407 1.0 1.0 25 Q15286,P61026,P31751,P62820,P31749,Q7Z392 6 +Response of eif2ak1 hri to heme deficiency 0.5402828017099528 0.3676681839715073 0.7131206668260441 1.0 1.0 3 P20042,P08243 2 +Integration of energy metabolism 0.3801821673110111 0.361983212982066 0.7173645751068529 1.0 1.0 21 P17612,P30154,O43865,O00763,Q13085 5 +Late endosomal microautophagy 0.3737459267689497 0.3541499888312485 0.7232264808763536 1.0 1.0 11 Q9H9H4,Q96EY5 2 +Transcription of the hiv genome 0.3754776118935817 0.3498533588549534 0.7264487518208547 1.0 1.0 23 P50750,P29083 2 +Golgi to er retrograde transport 0.3087066095298258 0.3451277972698761 0.72999829667866 1.0 1.0 68 P04350,Q9UJW0,Q96Q89,P43034,Q9BW19,Q6NUQ1,Q92538,O60333,P68402,O75935,Q86Y91,O43237,P35606,P62820,Q02241,Q9NZ32,P24390,O15260,P53621,O43731,Q10471 21 +Interferon gamma signaling 0.3751231104147027 0.3431233340782954 0.7315056774969744 1.0 1.0 14 P10321,P42224,Q05655,P19474,Q13555 5 +Copi dependent golgi to er retrograde traffic 0.277363992410843 0.32794921369759 0.7429500624006367 1.0 1.0 46 P24390,P04350,Q86Y91,Q96Q89,Q9BW19,P62820,Q6NUQ1,P35606,Q92538,Q02241,O43731,O60333 12 +Neurexins and neuroligins 0.3584329140484804 0.3081342821729249 0.7579801560830015 1.0 1.0 9 Q14168,Q15334 2 +Apoptotic cleavage of cellular proteins 0.368125004407662 0.3065301303875942 0.7592010424703919 1.0 1.0 20 Q05397,Q9UDY2,Q16625,P15924,Q05655 5 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.4161129603518015 0.295726504310695 0.7674389545134319 1.0 1.0 5 P36404 1 +Rna polymerase iii transcription initiation from type 1 promoter 0.3662792699773179 0.2848600835340191 0.7757513382166525 1.0 1.0 8 O14802 1 +Trafficking of glur2 containing ampa receptors 0.4119916677603305 0.283294328187759 0.7769512247309778 1.0 1.0 5 Q96CW1 1 +Rna polymerase iii transcription 0.3512968756039788 0.2804597118705542 0.7791248308670513 1.0 1.0 9 O14802 1 +Methylation 0.390413035098901 0.2731582749888441 0.7847315523832565 1.0 1.0 6 Q9NZL9,P23526,Q99707,P21964 4 +Rhou gtpase cycle 0.3586207493966559 0.2725243107435004 0.7852189011419854 1.0 1.0 15 Q00610,P16333,O43396,Q92783,P60953,Q9NNW5 6 +Fcgamma receptor fcgr dependent phagocytosis 0.3380303619708406 0.2700419934743296 0.7871279471438943 1.0 1.0 32 Q05397,Q96F07,P16333,O43865,Q05655,Q9UQB8,O15511,P60953,Q7L576 9 +Autophagy 0.2549512879050015 0.269978035982932 0.7871771511285395 1.0 1.0 48 Q96EY5,Q9NS69,Q9Y4P8,P49815,Q9H9H4,P42345 6 +Signaling by notch 0.2762131517705121 0.2676710151931503 0.7889525624377778 1.0 1.0 58 P25786,O00231,P28070,P42224,P60900,P49721,Q99436,P28074,P20618,Q96J02,P31749,P63208,Q9HCE1 13 +Insulin receptor recycling 0.3477444688118803 0.2670083186311962 0.7894627562067678 1.0 1.0 9 Q93050,Q9Y487 2 +Regulation by c flip 0.6932938856015727 0.2651684994249382 0.7908796603417549 1.0 1.0 2 Q13546 1 +Caspase activation via death receptors in the presence of ligand 0.6932938856015727 0.2651684994249382 0.7908796603417549 1.0 1.0 2 Q13546 1 +Myogenesis 0.4051635058845094 0.2632240085957374 0.7923779269251696 1.0 1.0 5 P19022 1 +Mrna decay by 3 to 5 exoribonuclease 0.3535902309526372 0.2616584279999555 0.7935847937479485 1.0 1.0 13 Q9GZS3,Q969T7 2 +Negative regulators of ddx58 ifih1 signaling 0.357878515096827 0.2550251607924732 0.798703666091005 1.0 1.0 8 Q13526,Q7Z434 2 +Growth hormone receptor signaling 0.3823826000999043 0.2481997260043285 0.8039798783366834 1.0 1.0 6 P40763 1 +Esr mediated signaling 0.2770168072391586 0.2422499740489623 0.8085864742841027 1.0 1.0 44 Q05397,P50750,Q86X55,O43815,Q13951,P31751,O14646,P31749 8 +Iron uptake and transport 0.3483436723060262 0.2282162361426112 0.8194781398475675 1.0 1.0 17 P30519,P21283,Q93050,Q9Y487,P63208 5 +Signaling by egfr 0.3390590616091353 0.2271890672407149 0.8202767285235748 1.0 1.0 10 P22681,Q92783 2 +Response of eif2ak4 gcn2 to amino acid deficiency 0.305107292766622 0.2252052240109686 0.821819625659068 1.0 1.0 75 P62910,P61313,P61927,Q92616,P46776,P35268,P18077,P36578,P46783,P84098,Q02543,P27635,P62241,P62701,P46778,P18124,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q07020,Q9Y3U8,P83731 26 +Golgi cisternae pericentriolar stack reorganization 0.3352867617644122 0.2069149258666673 0.8360762996083095 1.0 1.0 11 O95067 1 +Dna double strand break repair 0.2537650398476635 0.2056350229213374 0.8370760177985936 1.0 1.0 52 Q07864,P24941,P49005,P41440,O96028,P40937,P20248,Q92547,Q9Y2S7,P35251,P27694,P12956,Q99496,Q9UQ84,P18887,P78527,Q9NRF9,P40938 18 +Processive synthesis on the lagging strand 0.3348520929215822 0.1938932090591774 0.8462595011821477 1.0 1.0 13 Q9Y2S7,P27694,P49005,Q14181 4 +Rhoa gtpase cycle 0.2563599737348608 0.1938730049433752 0.8462753215727743 1.0 1.0 46 Q14739,Q92888,P30519,P41440 4 +Rna polymerase ii transcribes snrna genes 0.337814417318434 0.1932601235419512 0.8467552543610735 1.0 1.0 23 Q9H0H0,P50750,P29083 3 +Programmed cell death 0.3482729902529199 0.1882164013642063 0.8507070158276213 1.0 1.0 100 O00231,Q16625,P49721,P28074,P20618,P28070,P41440,P15924,Q07021,P31751,Q05397,P25786,Q14997,Q9UDY2,P25054,Q99436,P10412,P60900,P31749,P40763,Q05655,Q13546 22 +Eukaryotic translation elongation 0.3006837147181317 0.1878221272511573 0.8510160894179752 1.0 1.0 76 P62910,P61313,P61927,P46776,P35268,Q05639,P18077,P36578,P46783,P84098,Q02543,P27635,P62241,P62701,P46778,P18124,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q07020,Q9Y3U8,P83731 26 +Adherens junctions interactions 0.349418287945933 0.1876050238227858 0.8511862877337746 1.0 1.0 7 P19022,P14923 2 +Formation of rna pol ii elongation complex 0.3332711764897745 0.1842429281308159 0.8538228840933662 1.0 1.0 25 P50750,Q6PD62,Q9GZS3,P18074,P19447,Q96ST2 6 +Signaling by met 0.335778763380833 0.1808190927270368 0.8565095763056492 1.0 1.0 19 Q05397,P07942,P22681 3 +Rac3 gtpase cycle 0.3177746880317775 0.180744464617347 0.856568155808993 1.0 1.0 32 Q9UQB8 1 +Nf kb is activated and signals survival 0.6397107166337885 0.1717237347234249 0.8636547253834304 1.0 1.0 2 Q13501 1 +P75ntr recruits signalling complexes 0.6397107166337885 0.1717237347234249 0.8636547253834304 1.0 1.0 2 Q13501 1 +P75ntr signals via nf kb 0.6397107166337885 0.1717237347234249 0.8636547253834304 1.0 1.0 2 Q13501 1 +Tp53 regulates transcription of cell cycle genes 0.3301928143255311 0.1698169408596263 0.8651541035588302 1.0 1.0 15 P20248,P24941,O95628,Q86X55,Q99873 5 +Condensation of prometaphase chromosomes 0.3218746758273182 0.1688792839069907 0.8658915941867038 1.0 1.0 10 P67870,O95067 2 +Transcriptional regulation by runx1 0.2821263373774793 0.1643417758257005 0.869462096391656 1.0 1.0 69 O00231,Q16625,P28066,O14497,P49721,Q13951,P28074,P20618,Q96J02,Q99873,Q9HCE1,P28070,P25786,Q14997,Q12824,Q99436,P60900,Q96ST3,Q99496 19 +Factors involved in megakaryocyte development and platelet production 0.2624230755587309 0.1623313693870516 0.8710449130821336 1.0 1.0 44 P17612,P04350,Q96ST3,P24941,Q86Y91,Q96Q89,Q00535,Q9BW19,P60953,Q02241,O60333 11 +Mitotic telophase cytokinesis 0.3213358523717108 0.1547765448381745 0.8769974828651297 1.0 1.0 12 Q02241,Q9Y6X3 2 +Gap junction trafficking and regulation 0.3202749466541544 0.1514563382245612 0.8796157504985884 1.0 1.0 12 P04350,Q96CW1 2 +Oncogenic mapk signaling 0.3239685515427593 0.1508658430975104 0.8800815452916277 1.0 1.0 25 P21359,Q9NRY5,Q13555 3 +Cytosolic sensors of pathogen associated dna 0.3261902090290272 0.1486119201107148 0.8818598665780295 1.0 1.0 19 O14802,Q9H2U1,Q9BUI4,P12956,Q13546,P19474,P78527 7 +Loss of function of mecp2 in rett syndrome 0.3594164958503852 0.1472335377825204 0.8829476897273951 1.0 1.0 5 P17612 1 +Rho gtpases activate formins 0.2579599949891099 0.1454129413552876 0.884384847539589 1.0 1.0 59 P04350,Q8NFH4,P30153,Q9P258,P30154,O43237,P43034,P61586,Q8NBT2,Q92674,P60953,P50748,Q9HBM1,Q8NFH3,P35080 15 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3111795257813571 0.144676712257639 0.8849661266096309 1.0 1.0 31 Q9NZ32,P04350,O75935,O60884,Q9UJW0,O43237,Q13451,P31689 8 +Apc cdc20 mediated degradation of nek2a 0.3158286575700311 0.1434851390795364 0.8859070471029198 1.0 1.0 11 Q96DE5,Q12834,Q9H1A4 3 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3158286575700311 0.1434851390795364 0.8859070471029198 1.0 1.0 11 Q96DE5,Q12834,Q9H1A4 3 +Gap junction degradation 0.3436592185158675 0.1427919285063018 0.8864545118760636 1.0 1.0 6 Q96CW1 1 +Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.3682824583448224 0.1390852477703164 0.8893827854904279 1.0 1.0 4 P31749 1 +Phospholipid metabolism 0.2849667659009276 0.1326557553479399 0.8944656356346978 1.0 1.0 38 Q9NQZ5,Q99829,Q9UBF8,P35790,Q9NPH0 5 +Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.314558629776025 0.1219400809630291 0.9029464724488424 1.0 1.0 8 P45974,P22314,Q93008,Q16763,Q93009,P61086,P68036 7 +G alpha 12 13 signalling events 0.3336270238526933 0.1198223473007406 0.9046238788956572 1.0 1.0 6 Q92888 1 +Sumoylation of transcription factors 0.4149950674120328 0.1121876860751911 0.9106745926188788 1.0 1.0 3 Q13330,P04637 2 +Raf activation 0.2988812937619228 0.1072638768807245 0.9145796412363 1.0 1.0 9 Q13555,P30154 2 +Tp53 regulates transcription of cell death genes 0.3386821911421127 0.1060526729406533 0.9155405608230502 1.0 1.0 5 P53611 1 +Antigen presentation folding assembly and peptide loading of class i mhc 0.3068679494899268 0.0993167813290914 0.920886754717224 1.0 1.0 15 O95487,Q9NZ08 2 +Synthesis of pi 0.5802103879026886 0.0992356908569786 0.9209511374989324 1.0 1.0 2 O14735 1 +Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.4028880377620503 0.0975344844417933 0.9223019501438796 1.0 1.0 3 P62942 1 +Sema4d in semaphorin signaling 0.3043968270578108 0.0962810364331503 0.9232973718426948 1.0 1.0 8 P60660,P61586 2 +Nonsense mediated decay nmd 0.2999241427528141 0.0959280488110133 0.9235777175728948 1.0 1.0 85 P63151,Q9UPR3,P62910,P61313,P61927,P46776,P30153,P18077,P36578,P46783,P84098,Q02543,P27635,Q9HAU5,P62241,P62701,P46778,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q9Y3U8,P83731 26 +Rip mediated nfkb activation via zbp1 0.3323461665021592 0.0949322949529101 0.9243686046866004 1.0 1.0 5 O14920,Q9NZI8,Q13546,Q08211 4 +Organelle biogenesis and maintenance 0.2968887652185441 0.0913573275226826 0.927208667607595 1.0 1.0 84 P04350,A6NIH7,P48735,Q86X55,Q15154,Q9NQ48,P17612,Q96A65,P30153,P41208,P43034,Q9UPT5,Q9Y512,Q92538,O43924,O75935,O95684,Q13505,A0AVF1 19 +Tp53 regulates metabolic genes 0.2812748036665617 0.091171723150106 0.9273561430129256 1.0 1.0 36 Q15526,P31751,Q9BSH4,P42345,P49815,P31749,Q9HCE1 7 +Caspase mediated cleavage of cytoskeletal proteins 0.3183015141540516 0.08834751277541 0.9296004768275216 1.0 1.0 6 Q15149,Q13813,P42574,P35611,P08670 5 +Copi mediated anterograde transport 0.2257828875520508 0.0799978637167426 0.936238955033893 1.0 1.0 50 Q9NZ32,P04350,P24390,O75935,O43237,Q9UJW0,P53621,P62820,P35606,Q92538,O43731 11 +Signaling by ntrk3 trkc 0.5565417488494339 0.0789998900159189 0.9370327105459386 1.0 1.0 2 Q07812 1 +Rac1 gtpase cycle 0.2616798946281379 0.0761739174723635 0.939280733226832 1.0 1.0 40 Q9UQB8 1 +Separation of sister chromatids 0.3294635732481887 0.0757783928663464 0.9395954066826796 1.0 1.0 103 P04350,Q8NFH4,O00231,P30154,P28066,P49721,Q92674,P28074,P20618,P50748,Q7Z5K2,P28070,P30153,P43034,Q8NBT2,Q96DE5,Q9H1A4,P25786,Q14997,Q9P258,O43237,Q99436,P60900,Q8NFH3,Q12834,Q9HBM1 26 +Mitotic spindle checkpoint 0.2309047346919192 0.0754773130006125 0.9398349476418544 1.0 1.0 53 Q8NFH4,P30153,Q9P258,P30154,O43237,P43034,Q8NBT2,Q92674,Q96DE5,Q9H1A4,P50748,Q8NFH3,Q9HBM1 13 +Synthesis of pyrophosphates in the cytosol 0.5512820512820409 0.0751060817436035 0.9401303089630486 1.0 1.0 2 Q13572 1 +Dap12 interactions 0.3253289473684371 0.0738934289023279 0.9410951845322376 1.0 1.0 4 P10321,P01889,P62993 3 +Protein protein interactions at synapses 0.2932034698877392 0.0675579859524818 0.9461375013011926 1.0 1.0 14 Q14168,P41440 2 +Polb dependent long patch base excision repair 0.303159973666889 0.0615589638953741 0.9509140569978296 1.0 1.0 6 P27695,P39748,P09874,P18858,Q9NX46 5 +Interconversion of nucleotide di and triphosphates 0.2948808544333314 0.0614519151702634 0.9509993081211632 1.0 1.0 18 P22392,P00390,Q9H773,P17812 4 +Vitamin c ascorbate metabolism 0.3636961525813921 0.0613853328684385 0.9510523330059346 1.0 1.0 3 P00387,P11166 2 +Diseases associated with n glycosylation of proteins 0.2996930056557364 0.0560218406004749 0.9553244081985182 1.0 1.0 6 Q9BV10 1 +Frs mediated fgfr1 signaling 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr1 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Downstream signaling of activated fgfr2 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Frs mediated fgfr2 signaling 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Mapk1 erk2 activation 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P28482 1 +Activated ntrk2 signals through frs2 and frs3 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Frs mediated fgfr3 signaling 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Downstream signaling of activated fgfr3 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr3 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Stat5 activation 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Signaling by flt3 itd and tkd mutants 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr4 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Downstream signaling of activated fgfr4 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Stat5 activation downstream of flt3 itd mutants 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Downstream signaling of activated fgfr1 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Frs mediated fgfr4 signaling 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Pi 3k cascade fgfr2 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Tie2 signaling 0.5147928994082712 0.0534962622909899 0.9573365086465984 1.0 1.0 2 P62993 1 +Initiation of nuclear envelope ne reformation 0.2904414641200885 0.0528269976177924 0.9578697505406956 1.0 1.0 17 Q14739 1 +Disorders of transmembrane transporters 0.2695373294184972 0.0464340056616323 0.9629643331354312 1.0 1.0 76 P28074,P28070,O14678,P49721 4 +Activation of nmda receptors and postsynaptic events 0.2880904829062913 0.0431700076328632 0.965566013232754 1.0 1.0 21 P17612,P04350,Q13555,Q14168 4 +Rhoc gtpase cycle 0.2729874388077904 0.0407743367060594 0.9674757986812292 1.0 1.0 33 Q14739,Q92888,P41440 3 +Regulation of expression of slits and robos 0.3553461558258342 0.0379918916132466 0.9696941469177852 1.0 1.0 123 P62910,P61313,O00231,P28066,P61927,P49721,P46776,P28074,P20618,P28070,P18077,P36578,P46783,P84098,Q15369,Q02543,P27635,P25786,Q9HAU5,Q14997,P62241,P62701,P46778,Q99436,P60900,P83881,P62753,P62917,O94813,P18621,P62266,P08708,P39023,Q07020,Q9Y3U8,P83731 36 +Tp53 regulates transcription of genes involved in cytochrome c release 0.4579224194608728 0.0348515283136889 0.9721981319113482 1.0 1.0 2 Q07812 1 +Selenoamino acid metabolism 0.2880510794936527 0.030645233350104 0.9755524680774056 1.0 1.0 88 P62910,P61313,O43324,P61927,P46776,P00390,P18077,P36578,O43252,Q15046,P46783,Q9P2J5,P84098,Q02543,P27635,P62241,P62701,P46778,P83881,P62753,P62917,P18621,P62266,P08708,P39023,Q9Y3U8,P83731 27 +Bile acid and bile salt metabolism 0.2675577036082822 0.0265989917085105 0.9787795774763391 1.0 1.0 4 P22059 1 +Synthesis of bile acids and bile salts 0.2675577036082822 0.0265989917085105 0.9787795774763391 1.0 1.0 4 P22059 1 +Inla mediated entry of listeria monocytogenes into host cells 0.3833004602235288 0.0265523821282833 0.9788167534103962 1.0 1.0 2 O60716 1 +Dual incision in tc ner 0.2690569309096539 0.0257848724970468 0.9794289278368956 1.0 1.0 32 Q07864,P49005,P41440,P40937,Q16531,Q9Y2S7,Q93009,P35251,P18074,P19447,Q9NRF9,P40938 12 +Gaba synthesis release reuptake and degradation 0.3514135437212323 0.0255539680100031 0.979613102273692 1.0 1.0 2 P51649 1 +Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.3497698882314259 0.025522070109337 0.9796385448181096 1.0 1.0 2 P49327 1 +Signaling by fgfr2 0.2786128494666308 0.0237087738209505 0.9810849074769898 1.0 1.0 20 P31943,P52597 2 +Signaling by fgfr 0.2786128494666308 0.0237087738209505 0.9810849074769898 1.0 1.0 20 P31943,P52597 2 +Wnt5a dependent internalization of fzd4 0.2692823819322011 0.0186426713871886 0.9851261618981112 1.0 1.0 7 Q96CW1 1 +Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.2692823819322011 0.0186426713871886 0.9851261618981112 1.0 1.0 7 Q96CW1 1 +Neurotransmitter receptors and postsynaptic signal transmission 0.2692052986028536 0.0178261704217852 0.98577752709765 1.0 1.0 30 P17612,P04350,Q96CW1,Q14168,Q13555 5 +Signaling by interleukins 0.3223038173094688 0.0153160840279066 0.9877800107898356 1.0 1.0 109 O00231,P30154,Q13126,P22681,P49721,P28074,P20618,P22626,P17612,P28070,P30153,P51452,P52597,P63208,Q53EL6,P25786,Q14997,Q99439,P60953,Q99436,O14979,P14174,P60900,P31749,Q00169,Q8IV63,P40763,P42224 28 +Peroxisomal lipid metabolism 0.2589240411662654 0.012517436897541 0.9900127911689864 1.0 1.0 10 Q15067 1 +Hsf1 dependent transactivation 0.2648165959713572 0.0091824928287168 0.9926735337014724 1.0 1.0 14 Q13555 1 +Resolution of sister chromatid cohesion 0.2293209948066663 0.0072629847476375 0.9942050275529392 1.0 1.0 62 P04350,Q8NFH4,Q7Z5K2,P30153,Q9P258,P30154,O43237,P43034,Q8NBT2,Q92674,P50748,Q8NFH3,Q9HBM1,O95067 14 +Formation of tubulin folding intermediates by cct tric 0.2619597492576694 0.0071926158875128 0.9942611723134314 1.0 1.0 13 P68371,P04350,P40227,Q9BUF5,Q99832,P50991,P49368,P50990,Q9BVA1,P78371,P17987,Q13885 12 +Regulation of insulin secretion 0.2579379114263552 0.0070364628364186 0.994385761268716 1.0 1.0 11 P17612 1 +Apoptotic execution phase 0.2605777669098768 0.0041074473033335 0.9967227404275364 1.0 1.0 31 Q16625,P15924,Q05397 3 +Cell cell communication 0.2657860335501921 0.0036313730645022 0.9971025898652816 1.0 1.0 27 Q05397,P55196,Q13418,P19022,P14923,Q96J84 6 +Crmps in sema3a signaling 0.2382362619282771 0.0021109864262049 0.9983156777734308 1.0 1.0 5 Q14195,O14786,Q00535,Q16555 4 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9a775932d4d419e31c5354f0c1e2e2fff5728965 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "Butyrophilin btn family interactions", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd22 mediated bcr regulation", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Chylomicron clearance", "Chylomicron remodeling", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Common pathway of fibrin clot formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of particulate exogenous antigens phagosomes", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of base excision repair", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 activates ptk6 signaling", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythropoietin activates phosphoinositide 3 kinase pi3k", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Erythropoietin activates stat5", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling by cbl mutants", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of angiotensinogen to angiotensins", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna editing c to u conversion", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming and elongation in the cis golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotoxicity of clostridium toxins", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 promotes hif1a stabilization", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Ptk6 regulates rtks and their effectors akt1 and dok1", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Reelin signalling pathway", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of signaling by nodal", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sodium proton exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of glycosylphosphatidylinositol gpi", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 dependent activation of irf3 irf7", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Toxicity of botulinum toxin type d botd", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldl clearance", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO10", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "APLP2", "APOB", "APOBEC3C", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCL10", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BSG", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CDS2", "CENPI", "CENPM", "CEP290", "CERK", "CERS1", "CERS2", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHTOP", "CHUK", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLCN7", "CLINT1", "CLIP1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMBL", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT4", "CNOT9", "COG7", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTC", "CWC15", "CXADR", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH2", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFTUD2", "EGFR", "EHD1", "EHMT1", "EHMT2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERLIN2", "ERO1A", "ESD", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM3C", "FAM49B", "FAM91A1", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTB", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C3", "GTF3C4", "GUSB", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HECTD3", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILK", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INCENP", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISCU", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIRREL1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRP1", "LRP2", "LRPPRC", "LRRC1", "LRRC8E", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LYN", "LYPLA1", "LZTFL1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP2K1", "MAP2K4", "MAPK1", "MAPK3", "MAPRE1", "MARC1", "MARCKS", "MARS", "MASTL", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "METAP2", "METTL1", "METTL7A", "MFGE8", "MFN1", "MGAT1", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MPV17", "MRC2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO6", "MYO9B", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCK1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEK9", "NELFCD", "NELFE", "NEU1", "NF1", "NFS1", "NHLRC2", "NHP2", "NID1", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NT5C2", "NT5C3B", "NTHL1", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIN1", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PMPCA", "PMPCB", "PMVK", "PNO1", "PNP", "POFUT1", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPH", "PTBP1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS1", "PUS7", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RALGAPB", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOX2", "RIPK1", "RNASET2", "RNF14", "RNF2", "RNF220", "RNF40", "RNMT", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP8", "RRP9", "RSF1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD2", "SMYD3", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORL1", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX10", "STX18", "STX3", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF1", "SURF4", "SUZ12", "SV2A", "SYMPK", "SYNE2", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM30A", "TMEM59", "TMEM87A", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMX3", "TNKS1BP1", "TNPO1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT11", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TST", "TSTA3", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXNDC5", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFD1", "UFL1", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VLDLR", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "XAB2", "XPC", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AASDHPPT", "ABCD4", "ABHD10", "ACACA", "ACACB", "ACOX1", "ACP6", "ACTL6A", "ACTR10", "ADD1", "ADPRHL2", "AFDN", "AGPS", "AHCY", "AHCYL1", "AKT1", "AKT2", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALG12", "ANAPC1", "ANAPC16", "ANAPC7", "ANK3", "AP2M1", "APC", "APEX1", "ARHGAP17", "ARHGEF1", "ARID1A", "ARIH2", "ARL2", "ARPC5", "ASH2L", "ASNS", "ATP6V0A1", "ATP6V0A2", "ATP6V1C1", "BAG4", "BAIAP2", "BAX", "BLMH", "BLVRA", "BPHL", "BRD7", "C1QBP", "CAMK2G", "CARM1", "CASP3", "CBFB", "CBL", "CCNA2", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CDC20", "CDC23", "CDC27", "CDC42", "CDH2", "CDIPT", "CDK2", "CDK4", "CDK5", "CDK9", "CENPI", "CERS1", "CERS2", "CETN2", "CHAC2", "CHD1", "CHD3", "CHKA", "CLASP1", "CLTC", "CNN2", "CNOT4", "COMT", "COPA", "COPB2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "CPNE1", "CPT2", "CSNK1A1", "CSNK2B", "CTNND1", "CTPS1", "CTR9", "CYB5R3", "CYFIP1", "CYFIP2", "CYP51A1", "DCAF1", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DDB1", "DHCR24", "DHCR7", "DHFR", "DHX36", "DHX9", "DICER1", "DNAJA1", "DNAJA2", "DOHH", "DPYSL2", "DPYSL3", "DSC1", "DSC3", "DSP", "DUSP3", "DYNC1LI2", "EEF1A2", "EEF1E1", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "ELAC2", "ELOC", "ELP3", "EPHX1", "ERAP1", "ERCC2", "ERCC3", "EXO1", "EXOC2", "EXOC4", "EXOC7", "FAM114A2", "FASN", "FDFT1", "FEN1", "FGFR1OP", "FKBP1A", "FKBP5", "FN3KRP", "FNTB", "GALNT2", "GBF1", "GCN1", "GINS1", "GINS2", "GINS4", "GLMN", "GOLGB1", "GPS1", "GRB2", "GSR", "GSTA4", "GSTM3", "GTF2E1", "HAUS3", "HAUS5", "HAUS6", "HIST1H1E", "HLA-B", "HLA-C", "HLCS", "HMMR", "HMOX2", "HNRNPA2B1", "HNRNPDL", "HNRNPF", "HNRNPH1", "HTT", "ICMT", "IDH1", "IDH2", "IGF2BP1", "IKBKB", "ILK", "INTS2", "ITCH", "ITGAV", "ITPK1", "IWS1", "JUP", "KARS", "KDELR1", "KDELR3", "KDM1B", "KDSR", "KEAP1", "KHDRBS1", "KIF18B", "KIF1B", "KIF20B", "KIF23", "KIFC1", "KIRREL1", "KNTC1", "KPNA6", "LAMB1", "LARS", "LBR", "LIG1", "LLGL1", "LNPEP", "LTN1", "LZTFL1", "MAPK1", "MAPRE1", "MAT2B", "MAU2", "MAVS", "MCCC1", "MCM4", "MCM7", "ME1", "MED1", "MED12", "MED17", "MED24", "MED4", "MIF", "MOV10", "MPG", "MPP2", "MSH6", "MTA1", "MTA2", "MTAP", "MTOR", "MTR", "MTX1", "MVB12A", "MYH14", "MYL6", "NADK2", "NAMPT", "NCK1", "NEDD4L", "NF1", "NME2", "NOP10", "NPEPPS", "NRBP1", "NRP1", "NSD2", "NT5C3B", "NTHL1", "NUBP2", "NUP37", "NUP43", "OCLN", "ORC3", "ORC5", "OSBP", "OTUB1", "OTUD7B", "PAFAH1B1", "PAFAH1B2", 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Q07864,P49005,P41440,P40937,Q9Y2S7,P35251,Q9UQ84,P52701,Q9NRF9,P40938 10 +Cardiac hypertrophic response 0.6492208122686443 1.7216089497025933 0.0851403808629016 1.0 0.9170301722772254 12 P31751,P31749,P50750,P42345 4 +Wntbetacatenin signaling pathway in leukemia 0.762349252509925 1.7082873873214246 0.0875830304431213 1.0 0.9170301722772254 5 P14923,P31749,P48729 3 +Wnt signaling pathway 0.6454784467719561 1.7026741769711589 0.0886290599921482 1.0 0.9170301722772254 12 P48729,P61586,P49815,P31749,P42345 5 +Mesodermal commitment pathway 0.6129923452914798 1.6300961457518828 0.1030811782002725 1.0 0.9170301722772254 21 P17612,P42858,Q07021,Q12948,Q16527,O95071,Q13085 7 +Fragile x syndrome 0.4770445771481371 1.626860845026903 0.1037666555286036 1.0 0.9170301722772254 41 P17612,Q96F07,Q06787,P51452,P51648,Q96CW1,P49815,Q15334,Q7L576,Q9UPY3,Q9NZ01,P21359,Q08209,P31749,P42345,O43156 16 +Pi3kaktmtor signaling pathway and therapeutic opportunities 0.8858927984215667 1.5962528209304554 0.1104323588581908 1.0 0.9170301722772254 3 P49815,P42345 2 +Neurodegeneration with brain iron accumulation nbia subtypes pathway 0.6241098356950256 1.5929449238243063 0.1111725470891 1.0 0.9170301722772254 10 P49815,Q13085,Q9Y4P8 3 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.6010014586729712 1.562604391989357 0.1181456746190865 1.0 0.9170301722772254 21 Q15392,Q14739,P37268,Q14534,Q16850,Q9UBM7 6 +Autophagy 0.6814595946275984 1.500350489420925 0.1335236373066461 1.0 0.9170301722772254 6 Q9Y4P8 1 +Corticotropinreleasing hormone signaling pathway 0.5980848519967267 1.4997087963510625 0.1336898510065214 1.0 0.9170301722772254 18 Q05397,Q05655,Q06520,Q13085,P31749,P14923 6 +Regucalcin in proximal tubule epithelial kidney cells 0.6554671760039428 1.4993793372027504 0.1337752508966558 1.0 0.9170301722772254 7 P31749,P42345 2 +Kisspeptinkisspeptin receptor system in the ovary 0.6811102611483437 1.4987833071056496 0.1339298565069953 1.0 0.9170301722772254 6 P31751,P31749 2 +Angiogenesis 0.8597421585407388 1.497125448839048 0.1343606190431376 1.0 0.9170301722772254 3 Q05397 1 +Cytosine methylation 0.7109899668820545 1.4876114668444194 0.136853387627529 1.0 0.9170301722772254 5 O75874,P48735 2 +Small cell lung cancer 0.6001723618988777 1.4828002626710015 0.1381274862689516 1.0 0.9170301722772254 15 Q05397,P24941,P07942,P11802,P31751,P63208,P31749 7 +Praderwilli and angelman syndrome 0.6998496473582196 1.4394005320043115 0.1500370737260636 1.0 0.9170301722772254 5 Q7L576,P11802 2 +1q211 copy number variation syndrome 0.5930694844863883 1.4363149493068734 0.1509127420809886 1.0 0.9170301722772254 10 Q16625,Q9NPH0,Q9UDY2,Q96J84 4 +Dna repair pathways full network 0.3823897186640308 1.4281572747377853 0.1532465951307502 1.0 0.9170301722772254 49 Q07864,P49005,P41208,P41440,P40937,Q16531,Q9Y2S7,P35251,P18074,P12956,Q9UQ84,P19447,P78527,P18887,P52701,Q9NRF9,P40938,P27695 18 +Onecarbon metabolism and related pathways 0.5876886048957891 1.407151396153411 0.1593825004577611 1.0 0.9170301722772254 11 P00390,P34896,P35790,P34897 4 +Relationship between inflammation cox2 and egfr 0.6579942801969538 1.394815363258833 0.1630715248107697 1.0 0.9170301722772254 6 P31751 1 +Proteasome degradation 0.4477846878836541 1.3870433250958698 0.1654285521460645 1.0 0.9170301722772254 41 P28074,P28070,P49721 3 +Embryonic stem cell pluripotency pathways 0.5800304271518929 1.3673745205856556 0.171507944478978 1.0 0.9170301722772254 12 P31751,P31749,P42345,P25054 4 +Ranklrank signaling pathway 0.5769629006165318 1.3659532588752017 0.1719536345984842 1.0 0.9170301722772254 16 Q05397,P22681,P60953,P31751,P31749,P42345 6 +Development of ureteric collection system 0.6489978891902717 1.3542344796768433 0.1756615819848184 1.0 0.9170301722772254 6 Q12948,Q13418 2 +Ketogenesis and ketolysis 0.6476930523066793 1.3483443344228438 0.1775476589065925 1.0 0.9170301722772254 6 O43772 1 +Type 2 papillary renal cell carcinoma 0.5981651550297673 1.34489178269556 0.1786601842799009 1.0 0.9170301722772254 8 Q92733,P23246,Q15369 3 +Resistin as a regulator of inflammation 0.6466301684452013 1.3435456660529586 0.1790953495472793 1.0 0.9170301722772254 6 P31751 1 +Thymic stromal lymphopoietin tslp signaling pathway 0.5752247042738676 1.3432566299966018 0.1791888902599083 1.0 0.9170301722772254 11 P40763,P62753,P31749,P42345 4 +Glioblastoma signaling pathways 0.5649311858834913 1.3427966364693504 0.1793378328311656 1.0 0.9170301722772254 20 P22681,P11802,Q05655,P31751,P52701,P21359,P49815,P31749 8 +Nrp1triggered signaling pathways in pancreatic cancer 0.5731236387205746 1.3324576105767587 0.1827098618933389 1.0 0.9170301722772254 13 Q05397,P31751,O14646,P31749 4 +Histone modifications 0.5706137219227437 1.3217521020745395 0.186250712755406 1.0 0.9170301722772254 14 Q9H7B4 1 +Epithelial to mesenchymal transition in colorectal cancer 0.5624627573096288 1.3157306219447824 0.1882644724542648 1.0 0.9170301722772254 19 Q16625,P15924,P31751,P14923,P31749 5 +Ampactivated protein kinase ampk signaling 0.5649466045426568 1.3013652575987888 0.1931334597702632 1.0 0.9208121562483202 16 P31751,O00763,P49815,Q13085,P42345 5 +Transcription factors regulate mirnas related to cardiac hypertrophy 0.6990568932333883 1.2999605906637706 0.1936144765621468 1.0 0.9208121562483202 4 P31751,P31749 2 +Estrogen signaling pathway 0.6352605142964596 1.2921800000886612 0.1962948161583506 1.0 0.9258620080021984 6 P17612 1 +Il9 signaling pathway 0.6094948356700042 1.2844960965489631 0.1989684285097559 1.0 0.9258620080021984 7 P40763,P50750 2 +Hereditary leiomyomatosis and renal cell carcinoma pathway 0.5636179225577678 1.2836200366699526 0.1992749354971619 1.0 0.9258620080021984 11 Q13085,O00763 2 +T cell receptor and costimulatory signaling 0.6925236091651379 1.2726339616674616 0.2031479613771747 1.0 0.936651669250485 4 P31749,P48729 2 +Leptininsulin signaling overlap 0.797435054258462 1.2602674345129157 0.207572903548022 1.0 0.9498032859318584 3 P31749,O14654 2 +15q112 copy number variation syndrome 0.6845394736842191 1.2392454534865032 0.2152546122869534 1.0 0.9730619771794092 4 Q06787,Q7L576,Q96CW5 3 +Hedgehog signaling pathway wp4249 0.6841371654393997 1.237563411216166 0.2158779883146371 1.0 0.9730619771794092 4 P17612 1 +Head and neck squamous cell carcinoma 0.5537222154072062 1.2326003850365352 0.2177248932139561 1.0 0.9738230517013792 14 P62753,P11802,P31751,P49815,P31749,P42345 6 +Disruption of postsynaptic signaling by cnv 0.5713606853950024 1.214303277818841 0.2246319344310605 1.0 0.9738230517013792 8 Q14168,Q7L576,Q13555 3 +Alpha 6 beta 4 signaling pathway 0.5500202702899938 1.2118247468916503 0.2255794732581577 1.0 0.9738230517013792 12 Q05397,P07942,Q05655,P31749,P42345 5 +Cholesterol biosynthesis pathway 0.5487798939497509 1.2072578319683505 0.2273328647183683 1.0 0.9738230517013792 11 Q16850,Q9UBM7,Q14534 3 +Energy metabolism 0.5462411488201798 1.2028121924645396 0.2290490055343914 1.0 0.9742647841040312 9 Q99873,Q13555,Q08209 3 +Nonhomologous end joining 0.7761066180381226 1.1793612585951758 0.2382543548721152 1.0 0.9942636180610164 3 P78527 1 +Translation factors 0.4541477029301503 1.178269674159139 0.2386891136073632 1.0 0.9942636180610164 37 O75153 1 +Serine metabolism 0.6090218949964191 1.1735317818870052 0.2405826195612643 1.0 0.9952870014726278 6 P78330,P34897 2 +Ras and bradykinin pathways in covid19 0.7686189866569428 1.1510283648232964 0.249720566473349 1.0 1.0 3 Q99829 1 +Dual hijack model of vif in hiv infection 0.6628669961842788 1.1487292324172635 0.250667648028112 1.0 1.0 4 Q13951 1 +Nocgmppkg mediated neuroprotection 0.6581839443961411 1.1292079778848343 0.2588101090663373 1.0 1.0 4 Q13555 1 +Erbb signaling pathway 0.5275199292936457 1.1053627771662888 0.2690024259726982 1.0 1.0 17 Q05397,P22681,P31751,Q13555,P42345 5 +Netrinunc5b signaling pathway 0.5286753290992134 1.1003466006359748 0.2711811352740336 1.0 1.0 14 Q05397,P31749,P30154 3 +Transcription cofactors ski and skil protein partners 0.618857282699653 1.0877711048272878 0.2766961686353997 1.0 1.0 5 P21359,Q96ST3 2 +Ethanol effects on histone modifications 0.5223410800622941 1.0756218325692664 0.2820964191258173 1.0 1.0 10 P41440 1 +Complement system 0.5202154909904916 1.0556943129583989 0.2911078962294233 1.0 1.0 13 P17612,P48729,P07942,Q99829,P26885 5 +Hijack of ubiquitination by sarscov2 0.579809213132577 1.0417058341114724 0.2975480833131567 1.0 1.0 6 Q13951 1 +H19 action rbe2f1 signaling and cdkbetacatenin activity 0.574472631188974 1.0177099896698876 0.3088157984481674 1.0 1.0 6 P11802,Q16527 2 +Vitamin a and carotenoid metabolism 0.7323849099416442 1.0147646214160382 0.3102180418467155 1.0 1.0 3 Q8WTV0 1 +Melanoma 0.5115284267074686 1.0100547060319032 0.3124690809866051 1.0 1.0 14 P21359,P31751,P11802 3 +Egfr tyrosine kinase inhibitor resistance 0.508643924423326 1.0031092438467113 0.3158081551136851 1.0 1.0 17 P21359,P31751,P31749,P42345 4 +Tryptophan metabolism 0.5084416943479128 0.9938447760581072 0.3202984432905857 1.0 1.0 14 Q15392 1 +Met in type 1 papillary renal cell carcinoma 0.5021132527911409 0.990292387528644 0.3220312263243645 1.0 1.0 20 Q05397,Q92733,Q14241,P22681,O43815,P60953,P31751,P31749 8 +16p112 distal deletion syndrome 0.5683090461135332 0.9900453552921784 0.3221519507278287 1.0 1.0 6 Q8NCF5 1 +Dna replication 0.4724618742240014 0.9820696317471844 0.3260655452033312 1.0 1.0 29 P33993,Q07864,P24941,P49005,P41440,P40937,Q14181,Q9Y2S7,P35251,Q9UBD5,O43913,P33991,P40938 13 +Joubert syndrome 0.5012464495245859 0.9568920221838716 0.3386217583261917 1.0 1.0 15 P41208,Q15154,P42345,P36404,O43924 5 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.5005038671895438 0.9522441346121764 0.3409731827680589 1.0 1.0 14 O60725,P48729,P25054,P11802,P55209,Q9UPY3,O75844 7 +G1 to s cell cycle control 0.490745611341326 0.9497216083095102 0.3422537271827792 1.0 1.0 22 P33993,Q07864,Q14181,P11802,Q9UBD5,O43913 6 +Thyroid hormones production and peripheral downstream signaling effects 0.496583436347031 0.9322948808988024 0.3511841525382759 1.0 1.0 15 P17612,P49815,P42345 3 +Genes controlling nephrogenesis 0.4917502113050536 0.926984053673454 0.3539348137617257 1.0 1.0 9 Q12948,O94813,Q96J84,Q13418 4 +Nonsmall cell lung cancer 0.4951292880923559 0.924158193079938 0.355403958764092 1.0 1.0 14 P31751,P11802 2 +Sterol regulatory elementbinding proteins srebp signaling 0.4627965449950566 0.9213910305421996 0.3568463099476897 1.0 1.0 29 P17612,O95487,P37268,Q14534,Q13085,Q16850,P31749,P42345 8 +Nucleotide excision repair 0.4759493142560396 0.8941650391836207 0.3712335947173448 1.0 1.0 24 Q07864,P41208,P49005,P41440,P40937,Q16531,Q9Y2S7,P35251,P18074,P19447,Q9NRF9,P40938 12 +Tnfrelated weak inducer of apoptosis tweak signaling pathway 0.4868660438303833 0.8896640381485327 0.3736463093734057 1.0 1.0 11 P31751,P31749 2 +Osteoblast differentiation and related diseases 0.5239527830648169 0.8846503201732753 0.3763452578518906 1.0 1.0 7 Q05655,P78527 2 +Il6 signaling pathway 0.4866198466265905 0.8841185485268598 0.3766322213123152 1.0 1.0 12 P40763,Q05655,P31749 3 +Pathways affected in adenoid cystic carcinoma 0.4856792684733921 0.8765881488177573 0.3807103785507419 1.0 1.0 16 P10412,P78527,Q6W2J9,O14497 4 +Endometrial cancer 0.485079595709285 0.873324083376693 0.3824864571980355 1.0 1.0 13 P31751,P31749,P25054 3 +Leptin signaling pathway 0.4627823304554789 0.8729251109316061 0.3827038982349813 1.0 1.0 27 Q05397,P62753,P40763,P61586,P60953,O00763,Q13085,Q07666,P31749,P42345 10 +Ciliopathies 0.4838104255466464 0.866794200125241 0.3860547805097936 1.0 1.0 13 Q15555,O43924 2 +Cancer immunotherapy by pd1 blockade 0.6915798475009354 0.8640143314049563 0.3875800178007447 1.0 1.0 3 P40763 1 +Tcell activation sarscov2 0.4811483026024157 0.8561851670271636 0.3918953658308131 1.0 1.0 12 P49815,P42345 2 +4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression 0.5151760915861933 0.8442678234489552 0.3985197621328828 1.0 1.0 7 P31749,P42345 2 +Mirna biogenesis 0.5884868421052741 0.8425798101460235 0.3994634866530733 1.0 1.0 4 Q9HAV4,P62826,Q9UPY3 3 +Interferon type i signaling pathways 0.4787918320333017 0.839302649645748 0.401299496740781 1.0 1.0 14 Q53EL6,P62753,P22681,P40763,Q99873,P42345 6 +Genes related to primary cilium development based on crispr 0.4756963308098157 0.833120123699581 0.4047769852617944 1.0 1.0 11 O95684,A0AVF1 2 +Focal adhesion pi3kaktmtorsignaling pathway 0.3790715057570505 0.8296254282658792 0.406750595299759 1.0 1.0 41 Q05397,P07942,O14654,P31751,P61026,P49815,Q13085,P31749,P42345 9 +Gastric cancer network 2 0.4760158717061608 0.8245944272621549 0.4096018862848005 1.0 1.0 15 Q14739,Q658Y4 2 +Mbdnf and probdnf regulation of gaba neurotransmission 0.5835564433975378 0.8227475673647507 0.4106515590778605 1.0 1.0 4 P40763,P61586 2 +Il7 signaling pathway 0.5292336217186141 0.8165236975241167 0.4142006756046181 1.0 1.0 6 P40763,P31749 2 +Epo receptor signaling 0.5085659535332434 0.8140129233985569 0.4156375475237712 1.0 1.0 7 P40763,P31749 2 +Base excision repair 0.4730466939336581 0.8126248254162354 0.416433193676665 1.0 1.0 17 Q07864,P49005,P18887,Q9NRF9,P27695 5 +Mirna regulation of dna damage response 0.4583512793280794 0.808576564970193 0.4187587491854649 1.0 1.0 25 P33993,Q86UE8,P24941,P41440,P11802,P78527,O95067 7 +Modulators of tcr signaling and t cell activation 0.4707847662031141 0.800114764214953 0.4236443077719649 1.0 1.0 13 O95376,Q12824 2 +Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition 0.550325224180743 0.7953630435138015 0.4264023509401216 1.0 1.0 5 P31749 1 +Methionine metabolism leading to sulfur amino acids and related disorders 0.5753289473684311 0.7898441510482253 0.4296187908960784 1.0 1.0 4 Q9NZL9,Q99707,P23526 3 +Atr signaling 0.6706063637741757 0.78823235043043 0.4305608096237385 1.0 1.0 3 Q92547 1 +Fibrin complement receptor 3 signaling pathway 0.5735297575468032 0.782682806000563 0.4338134015422965 1.0 1.0 4 P31749 1 +Neural crest cell migration during development 0.4984308611758262 0.7679326469549693 0.4425272005442657 1.0 1.0 7 P31751,P61586,P31749 3 +Integrated cancer pathway 0.464140216462803 0.7637269993225734 0.445029947672847 1.0 1.0 16 P11802,P31749,P24941,P52701 4 +Nongenomic actions of 125 dihydroxyvitamin d3 0.4766735048630178 0.7569267482477634 0.4490937492769433 1.0 1.0 8 Q15648,Q05655,Q13555 3 +Tgfbeta receptor signaling 0.5376326167529295 0.7427169551698722 0.4576530623625632 1.0 1.0 5 P40763,P62942 2 +Tgfbeta receptor signaling in skeletal dysplasias 0.5376326167529295 0.7427169551698722 0.4576530623625632 1.0 1.0 5 P40763,P62942 2 +Influence of laminopathies on wnt signaling 0.4550466910387749 0.7364647841531659 0.4614478913543929 1.0 1.0 10 O60725,P48729,Q5JTV8,Q9UPY3,O75844 5 +Bdnftrkb signaling 0.4720327412319 0.7351159176739568 0.4622689009245087 1.0 1.0 8 P49815,P31749,P42345 3 +Cell cycle 0.3266160123506428 0.7242468432497515 0.4689142048943995 1.0 1.0 46 P33993,Q9H1A4,P24941,P20248,P11802,Q9UBD5,O43913,P78527,P63208,O95067 10 +Retinoblastoma gene in cancer 0.3429598486305218 0.7238795007342893 0.469139716044449 1.0 1.0 44 P33993,Q07864,P24941,P20248,Q96ST3,P40937,P26358,P11802,P00374,P40938,P23921,P52701,P78527,P33991,Q9NQW6,O95067 16 +Tgfbeta signaling pathway 0.4117419683152422 0.7133785228099419 0.4756115594625933 1.0 1.0 33 Q05397,Q96ST3,Q9Y3F4,Q96PU5,P61586,P60953,Q96J02,P31749,P63208,O95067 10 +Oxidative damage response 0.5052801092131067 0.7126036982133815 0.4760910226650741 1.0 1.0 6 O95429 1 +Glutathione metabolism 0.5532357769749751 0.7028638838458668 0.4821405804365146 1.0 1.0 4 O75874 1 +Dna damage response 0.4422815866361485 0.7023320115220909 0.4824721342636726 1.0 1.0 24 Q86UE8,P24941,P41440,P11802,P78527,O95067 6 +Oncostatin m signaling pathway 0.451823002235362 0.7016760707471014 0.4828811993604562 1.0 1.0 17 P62753,P20248,P24941,P40763,Q05655,P31749,P42345 7 +Vasopressinregulated water reabsorption 0.4511358655866399 0.6982108550373473 0.4850453389216325 1.0 1.0 14 Q9UJW0 1 +Nicotine effect on dopaminergic neurons 0.5508258799613567 0.6935140419961039 0.4879870167309961 1.0 1.0 4 P17612 1 +Cell migration and invasion through p75ntr 0.500500339787743 0.6921789934029071 0.4888249290215267 1.0 1.0 6 P31751,P61586,P31749 3 +Insulin signaling in adipocytes diabetic condition 0.5242056213995508 0.6878156239389931 0.491568895958216 1.0 1.0 5 P31751,P42345 2 +Insulin signaling in adipocytes normal condition 0.5242056213995508 0.6878156239389931 0.491568895958216 1.0 1.0 5 P31751,P42345 2 +Mecp2 and associated rett syndrome 0.4457788037576122 0.6827872358168613 0.4947412964162456 1.0 1.0 20 P31943,P35637,P52597,P21359,P31749,P42345 6 +Physiological and pathological hypertrophy of the heart 0.4961037566274403 0.6734979559402062 0.5006305487363929 1.0 1.0 6 P61586,Q08209 2 +Il4 signaling pathway 0.443105928452636 0.6711087772212382 0.502151235853308 1.0 1.0 11 P40763,P22681,P31749 3 +Methylation pathways 0.6362882119285567 0.6677634530541482 0.5042845989085034 1.0 1.0 3 P21964 1 +Arrhythmogenic right ventricular cardiomyopathy 0.4448135530389495 0.6665654549260113 0.5050497410527379 1.0 1.0 14 P06756,P15924,P14923,P19022 4 +Mitochondrial long chain fatty acid betaoxidation 0.4418254568027855 0.6648612776231434 0.5061392247490659 1.0 1.0 11 O43772,Q16836 2 +Micrornas in cardiomyocyte hypertrophy 0.4409089682908745 0.6571017374067607 0.5111155018431366 1.0 1.0 20 P61586,P50750,P31751,Q08209,P31749,P42345 6 +Familial partial lipodystrophy fpld 0.4726006586185142 0.6526204205315995 0.5140010174435583 1.0 1.0 7 O60725,P31751 2 +Il10 antiinflammatory signaling pathway 0.5150892725459368 0.6510759145667852 0.5149974833719067 1.0 1.0 5 P40763,P42224 2 +Target of rapamycin tor signaling 0.4365410658649681 0.6462334243841888 0.5181281962344388 1.0 1.0 10 P49815,P31749,P42345,P62942 4 +Il2 signaling pathway 0.4377279877150284 0.6449425539168127 0.5189644137218858 1.0 1.0 11 P22681,P40763,P62753,P31749 4 +Splicing factor nova regulated synaptic proteins 0.4369669441753167 0.625720328279706 0.5314983972915495 1.0 1.0 15 Q7Z460,P11171,P19022,Q9UNS2,Q13555,Q9UBB6 6 +Transsulfuration and onecarbon metabolism 0.4354073536927846 0.6172854881985974 0.5370464369593466 1.0 1.0 16 P78330,P26358,P34897,O43865,P34896 5 +Thermogenesis 0.4265503266111421 0.6156967141340259 0.5380947063798684 1.0 1.0 24 P17612,P23786,Q12824,O43772,O14497,P49815,P42345 7 +Zinc homeostasis 0.8310322156476155 0.6128475457124967 0.5399771495311765 1.0 1.0 2 Q8NEW0 1 +Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc 0.4321706894820456 0.6020171814832616 0.5471627006242354 1.0 1.0 15 P11498,P50213 2 +Ccl18 signaling pathway 0.4252763918421289 0.5924049195815708 0.5535794728073422 1.0 1.0 10 P42224,P11166,P19022,Q86UE4,P08670 5 +Nucleotide excision repair in xeroderma pigmentosum 0.3848380524938382 0.5730324544403614 0.5666227197104208 1.0 1.0 34 Q07864,P41208,P49005,P41440,P40937,Q16531,Q9Y2S7,Q93009,P35251,P18074,P19447,P18887,Q9NRF9,P40938 14 +Disorders of folate metabolism and transport 0.4699931377409217 0.5649932953732179 0.5720783245140828 1.0 1.0 6 P34897 1 +Wnt signaling 0.4197752048191183 0.5480329268825685 0.583669294083585 1.0 1.0 13 P48729,P25054,P61586,Q13555,Q08209 5 +Pancreatic adenocarcinoma pathway 0.4136721215481975 0.5371041667950107 0.5911956627473469 1.0 1.0 23 P40763,P11802,P61586,Q05655,P60953,P31751,P31749,P42345 8 +Estrogen receptor pathway 0.7971729125575294 0.5155557878733665 0.6061646961441014 1.0 1.0 2 Q15067 1 +Gastrin signaling pathway 0.4031885506980184 0.5145592260718231 0.606861063725801 1.0 1.0 26 P17612,Q05397,P62753,Q05655,P61586,P60953,P31749,P42345 8 +Sphingolipid metabolism overview 0.4055902516394 0.5094831536547149 0.6104136036600676 1.0 1.0 9 Q06136 1 +Sphingolipid metabolism integrated pathway 0.4055902516394 0.5094831536547149 0.6104136036600676 1.0 1.0 9 Q06136 1 +Exrna mechanism of action and biogenesis 0.5882933245642744 0.509441005261673 0.6104431402372879 1.0 1.0 3 Q9HAV4,Q9UPY3 2 +Onecarbon metabolism 0.4108046754660298 0.5058658650782226 0.6129508167554374 1.0 1.0 13 P34897,P34896 2 +Breast cancer pathway 0.4068933138677082 0.5022291172365543 0.615506363349221 1.0 1.0 23 P48729,P11802,P31751,P63208,P42345 5 +G protein signaling pathways 0.4093392371415014 0.4921652954974875 0.6226024959150971 1.0 1.0 15 P17612,Q05655,Q08209,Q92888 4 +Sphingolipid pathway 0.4045166798595494 0.4884733217455148 0.6252146178970823 1.0 1.0 11 Q06136,Q9NRX5,Q96G23 3 +Clear cell renal cell carcinoma pathways 0.3331459351132042 0.4865989891764928 0.6265425400335958 1.0 1.0 41 P78330,P34897,O00763,P49815,Q13085,P42345,P34896 7 +Regulation of actin cytoskeleton 0.3592415136844962 0.4741183976673728 0.6354154798578768 1.0 1.0 36 Q05397,Q96F07,P25054,Q9UQB8,P61586,O15511,Q92888 7 +Serotonin and anxiety 0.7767915844838895 0.4602222452376769 0.6453567053399276 1.0 1.0 2 Q08209 1 +Il17 signaling pathway 0.4611763661545505 0.4456373191226773 0.6558592486307016 1.0 1.0 5 P31749 1 +Sphingolipid metabolism in senescence 0.3943411922949247 0.4427223299825604 0.6579665888635444 1.0 1.0 11 Q06136,P42345,Q96G23 3 +Translation inhibitors in chronically activated pdgfra cells 0.3948620342216207 0.4225671771105375 0.672611078481637 1.0 1.0 18 P17612,P62753,Q05655,P31751,P31749,P42345 6 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.3924416033080979 0.4223663687335086 0.6727576217400415 1.0 1.0 13 P55884,P55010,P60228,Q14152,O75822,O15372 6 +Neural crest cell migration in cancer 0.400259653097338 0.4164944930786186 0.6770481962201931 1.0 1.0 8 P31751,P61586,P31749 3 +Brainderived neurotrophic factor bdnf signaling pathway 0.3161708592893758 0.4132053000796479 0.6794562053079594 1.0 1.0 42 P62753,P25054,P40763,P42224,Q05655,Q00535,P60953,Q7L576,P19022,O00763,P49815,P31749,P42345 13 +Alzheimers disease 0.3451157284152384 0.4107268437449062 0.6812728411157964 1.0 1.0 81 P25786,P04350,P28070,P25054,P48729,P07384,Q00535,P49721,O14654,P31751,P28074,Q99436,P20618,Q9Y4P8,P60900,Q08209,P31749,P42345 18 +Dopamine metabolism 0.7511505588428877 0.3945661101145384 0.6931631285738482 1.0 1.0 2 P17612 1 +Burn wound healing 0.3779327385835243 0.3792509436768105 0.7045015245622217 1.0 1.0 10 P50454,P31749,Q99439 3 +Rala downstream regulated genes 0.4594133730421197 0.3690470092574724 0.7120926856927894 1.0 1.0 4 P60953 1 +Alzheimers disease and mirna effects 0.3407853548844378 0.364496457510966 0.7154873186315625 1.0 1.0 82 P25786,P04350,P28070,P25054,P48729,P07384,Q00535,P49721,O14654,P31751,P28074,Q99436,P20618,Q9Y4P8,P60900,Q08209,P31749,P42345 18 +Spinal cord injury 0.3794461361925377 0.3627717455286944 0.7167753999094626 1.0 1.0 22 O94813,P24941,P11802,P61586,P60953,P14174,P62942,Q08209 8 +Riboflavin and coq disorders 0.5364074278959974 0.3571175774460782 0.7210037860581391 1.0 1.0 3 P13804 1 +Nuclear receptors metapathway 0.2681794941421031 0.3503584714733518 0.7260696886104472 1.0 1.0 49 Q06520,O15217,P21266 3 +Folate metabolism 0.3775102003295433 0.3495882941194047 0.7266476972173872 1.0 1.0 15 P34897,P41440 2 +Ncrnas involved in wnt signaling in hepatocellular carcinoma 0.3687098238108567 0.3494344934502177 0.7267631413771019 1.0 1.0 9 Q86UE4,P48729,P25054 3 +Adipogenesis 0.3773001154274292 0.348697074459387 0.7273167408244046 1.0 1.0 15 Q9NZ45,P40763,O14654,Q92879,P14174,O75844,P43490 7 +Factors and pathways affecting insulinlike growth factor igf1akt signaling 0.3813472686941632 0.3412015525297802 0.7329518545916491 1.0 1.0 8 P31749,P42345,P49770 3 +Wnt signaling pathway and pluripotency 0.3756060076117335 0.3389221367982498 0.7346683876258613 1.0 1.0 16 P30153,P25054,P30154,P43034,Q05655,P61586 6 +Pi3kakt signaling pathway 0.31481544386345 0.3302159319641247 0.7412368094486976 1.0 1.0 40 Q05397,P62753,P30153,P24941,P30154,P07942,P06756,P11802,P31751,P49815,P31749,P42345 12 +Extracellular vesiclemediated signaling in recipient cells 0.3908951576400018 0.3224047230793398 0.7471461066028546 1.0 1.0 7 P31749,P42345 2 +Myometrial relaxation and contraction pathways 0.3691975259346122 0.3121507818947992 0.7549259348269355 1.0 1.0 16 P17612,Q13555,Q99439 3 +Exerciseinduced circadian regulation 0.3619766899382579 0.2895194611331765 0.7721838894414557 1.0 1.0 14 Q96PU8,P21266 2 +Angiopoietinlike protein 8 regulatory pathway 0.3526236975261779 0.2863279449673958 0.7746269566918902 1.0 1.0 28 P41440,P22681,O14654,P31751,P49815,P31749,P42345 7 +Hippo signaling regulation pathways 0.3621181612518845 0.2815107432475974 0.7783186892095357 1.0 1.0 17 P17612,Q05655,P61586,P19022,P42345 5 +Il3 signaling pathway 0.3577430184289779 0.2776148126158166 0.7813080601324418 1.0 1.0 13 P17612,P22681 2 +Vitamin d receptor pathway 0.3560223508302976 0.2662623312607864 0.7900371815269598 1.0 1.0 14 Q06520 1 +Photodynamic therapyinduced unfolded protein response 0.3470728323157497 0.2644901903736428 0.7914022227145687 1.0 1.0 9 Q13217 1 +Pathogenic escherichia coli infection 0.3515964222343968 0.2569369479562376 0.7972274474479535 1.0 1.0 25 P04350,O15144,Q16625,P16333,P61586,O15511,P60953,Q14247,Q92974,P07437 10 +Prolactin signaling pathway 0.3549608854650902 0.2567864482330574 0.7973436321199692 1.0 1.0 22 Q05397,P22681,P31749,P42345 4 +Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway 0.4162805038387477 0.2455702697864428 0.8060149058508705 1.0 1.0 4 Q14145,P09601 2 +Tolllike receptor signaling pathway 0.3492276826004704 0.2405562765417359 0.8098990413519183 1.0 1.0 14 Q15750,P42224,Q13546,P31751,P31749 5 +Dna damage response only atm dependent 0.3472098199958447 0.2240079410589646 0.8227511241724512 1.0 1.0 17 P31751,P61586,P31749,P25054 4 +Lncrna in canonical wnt signaling and colorectal cancer 0.3358850121785676 0.2089927572788079 0.8344538926315894 1.0 1.0 11 P61978,P48729,P25054 3 +Chromosomal and microsatellite instability in colorectal cancer 0.3396810429057483 0.1946876467454356 0.8456374833332083 1.0 1.0 20 P48729,P61586,P31751,P52701,P31749 5 +Atm signaling in development and disease 0.3369739115108767 0.1901574599499911 0.8491857448793594 1.0 1.0 23 P49815,Q14739,P42345 3 +Neuroinflammation and glutamatergic signaling 0.3351500015188072 0.1868970211145336 0.8517413748532165 1.0 1.0 24 P17612,P78330,P34897,Q13555,P34896 5 +Somatroph axis gh and its relationship to dietary restriction and aging 0.3916445918823737 0.186546843956456 0.852015947340061 1.0 1.0 4 P42345 1 +Fatty acid betaoxidation 0.335696311640877 0.1829061383162576 0.8548716664698075 1.0 1.0 17 O43772,Q16836 2 +Egfegfr signaling pathway 0.2821259610145682 0.180660441455814 0.8566341109251316 1.0 1.0 41 Q05397,P22681,P40763,Q92783,P42224,Q96CW1,Q05655,P60953,Q96J02,Q9P0J0,Q92888,P31749,P42345 13 +Cohesin complex cornelia de lange syndrome 0.334336414609315 0.1782529478555807 0.8585243291162181 1.0 1.0 17 Q7Z5K2,P30153,Q9Y6X3,P30154 4 +Transsulfuration pathway 0.3566174649509357 0.1751738680560659 0.8609430170967407 1.0 1.0 6 Q9NZL9,P26358 2 +Novel intracellular components of rigilike receptor rlr pathway 0.3237036218755022 0.1747920868984065 0.8612430063582364 1.0 1.0 10 Q13526,O00571,Q7Z434 3 +Physicochemical features and toxicityassociated pathways 0.3336819278221629 0.1735080089938327 0.8622521330931003 1.0 1.0 20 Q05397,P25054,P22681,P61586,P35080,P31749 6 +Quercetin and nfkb ap1 induced apoptosis 0.6397107166337863 0.1717237347234218 0.8636547253834328 1.0 1.0 2 Q14145 1 +Monoamine transport 0.4510348213029725 0.1663660185015706 0.8678689145592962 1.0 1.0 3 P49815 1 +Pdgfrbeta pathway 0.3383831765916975 0.1567981911013214 0.87540389851008 1.0 1.0 7 P40763,P42224,Q02750 3 +Airway smooth muscle cell contraction 0.3736633359380357 0.1492648066992985 0.8813446843140866 1.0 1.0 4 P61586 1 +Rett syndrome causing genes 0.3236022633259486 0.1485676613638621 0.8818947922520914 1.0 1.0 15 P28370,Q9Y4A5,P42858,Q9BXF3,P49770 5 +Nrf2 pathway 0.3217269565180438 0.1353868881042541 0.8923059904605066 1.0 1.0 22 O15217,P21266 2 +Melatonin metabolism and effects 0.6117685733070282 0.1336572483282089 0.8936736126399398 1.0 1.0 2 Q96EB6 1 +Agerage pathway 0.3211896377851211 0.1327406359466836 0.8943985043758758 1.0 1.0 19 P40763,Q05655,P61586,P60953,P31749 5 +Chemokine signaling pathway 0.317485316188927 0.1235915673882316 0.9016386695433972 1.0 1.0 23 Q05397,P40763,Q05655,P60953,P31751,P31749 6 +Integrinmediated cell adhesion 0.3166592751910186 0.121004569017989 0.9036874162368698 1.0 1.0 23 Q05397,P07384,Q13418,P60953,P31751,P31749 6 +Regulation of wnt bcatenin signaling by small molecule compounds 0.3528172371216563 0.1123472464750446 0.910548081628188 1.0 1.0 4 P48729 1 +Nrf2are regulation 0.3407213142689326 0.1097771989668623 0.9125860743250028 1.0 1.0 5 Q14145,P09601 2 +Insulin signaling 0.2656830018645572 0.1076405910987969 0.9142807969942814 1.0 1.0 41 P41440,P22681,O14654,P31751,P49815,P42345 6 +Cytosolic dnasensing pathway 0.3037117703122871 0.0983511220077159 0.921653485421062 1.0 1.0 13 O14802,Q7Z434 2 +Arachidonate epoxygenase epoxide hydrolase 0.5759368836291854 0.0952420335744854 0.9241225837489762 1.0 1.0 2 P20674 1 +Camkk2 pathway 0.296044364218837 0.0933709656447315 0.9256088557889102 1.0 1.0 10 Q13501,Q96EB6,P42345,O76024 4 +Effect of progerin on genes involved in hutchinsongilford progeria syndrome 0.2999832001204572 0.0929978413600185 0.9259052761371078 1.0 1.0 12 Q12873 1 +Microtubule cytoskeleton regulation 0.303813726317889 0.0857892638390214 0.931633941228305 1.0 1.0 17 P17612,P25054,P40763,P60953,P31749 5 +Vitamin d in inflammatory diseases 0.3863794526611515 0.0802870522444961 0.9360089557816724 1.0 1.0 3 Q08209 1 +Tca cycle aka krebs or citric acid cycle 0.2997475510301011 0.0776065135730993 0.93814106092892 1.0 1.0 16 P48735 1 +Hair follicle development organogenesis part 2 of 3 0.3834265044393292 0.0775217488623495 0.9382084902435954 1.0 1.0 3 P05556,Q9BZE4 2 +Glycerophospholipid biosynthetic pathway 0.3110599078341041 0.0750035096920158 0.9402119194303658 1.0 1.0 6 Q9BTU6,O14735,O00116,O15228,P48651 5 +Male infertility 0.2994022979316171 0.0706036929482859 0.9437131712025628 1.0 1.0 22 P34896,P50750,P41440 3 +Gaba metabolism aka ghb 0.5417488494411501 0.0685745599290936 0.9453282694207734 1.0 1.0 2 P51649 1 +Circadian rhythm genes 0.2741840664590865 0.0681731287810597 0.945647817319778 1.0 1.0 36 O14744,Q96EB6,Q96ST3,P49327,Q13330,P17844,P11802,P23246,Q9BWF3,O15294,P78527,P63208,P43490,Q15233 14 +Transcriptional activation by nrf2 in response to phytochemicals 0.3438600691610338 0.0489290701543082 0.9609758219679864 1.0 1.0 3 Q14145 1 +Eicosanoid synthesis 0.4976988823142533 0.046238442992358 0.96312020215087 1.0 1.0 2 Q9H7Z7 1 +Mirnas involvement in the immune response in sepsis 0.3346000267217476 0.0442606755630681 0.9646966172916778 1.0 1.0 3 Q15750 1 +Network map of sarscov2 signaling pathway 0.2853304312049968 0.0418626308488552 0.966608206530112 1.0 1.0 26 P62753,Q99829,Q07021,Q7Z434,Q96J02,P31749,P42345,O95067 8 +Calcium regulation in cardiac cells 0.2872032418103257 0.0411946293452807 0.9671407352017736 1.0 1.0 21 P17612,Q05655,Q13555 3 +Fgfr3 signaling in chondrocyte proliferation and terminal differentiation 0.289819257967711 0.0374683079751464 0.9701116089671472 1.0 1.0 5 P42224,P09543 2 +Complement and coagulation cascades 0.3114107201578471 0.0352989365884885 0.971841371283289 1.0 1.0 3 Q00610,P49257 2 +Tp53 network 0.4579224194608728 0.0348515283136889 0.9721981319113482 1.0 1.0 2 Q07812 1 +Hepatitis b infection 0.2819512337583448 0.0323690795999225 0.974177720465586 1.0 1.0 25 P40763,P31751,O00571,Q7Z434,P31749 5 +Ras signaling 0.272704482442374 0.029461846620019 0.9764962477094128 1.0 1.0 31 P17612,P55196,P61586,P31751,P21359,P31749 6 +Hippoyap signaling pathway 0.4053254437869756 0.0278643938297846 0.9777703070171352 1.0 1.0 2 Q13043 1 +Hypertrophy model 0.2739230516277601 0.0271391500606047 0.9783487490177728 1.0 1.0 3 O75083,P20248 2 +Liver x receptor pathway 0.3497698882314259 0.025522070109337 0.9796385448181096 1.0 1.0 2 P49327 1 +Pyrimidine metabolism 0.2443065047414271 0.023549808397423 0.981211708129895 1.0 1.0 40 O14802,Q07864,P17812,Q14181,Q9BUI4,P22392,Q9H773,Q9NRF9 8 +Regulatory circuits of the stat3 signaling pathway 0.2582900080140655 0.0114226469220929 0.9908862445668268 1.0 1.0 10 Q96B36,P40763,Q8WTS6,P42345 4 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0784ec88e9212be57fadf295232dd7a658cf95ca --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Ace inhibitor pathway", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes associated with the development of rheumatoid arthritis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpcrs class b secretinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Lipid particles composition", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirna targets in ecm and membrane receptors", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanomaterialinduced inflammasome activation", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoblast signaling", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Scfa and skeletal muscle substrate metabolism", "Selective expression of chemokine receptors during tcell polarization", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Tamoxifen metabolism", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ABI1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADGRE5", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK4", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA4", "ANXA6", "AP1G1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APC", "APEX1", "APLP2", "APMAP", "APOB", "APP", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL8B", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATG3", "ATG7", "ATIC", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AURKA", "B3GALT6", "BAG3", "BAG4", "BAIAP2", "BANF1", "BAX", "BAZ1A", "BAZ1B", "BCAT1", "BCAT2", "BCL10", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BLVRA", "BLVRB", "BRCA1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CANT1", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPZB", "CARM1", "CASP2", "CASP3", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD320", "CD46", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CDS2", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CEP170", "CEP290", "CEP44", "CERK", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHKA", "CHMP5", "CHORDC1", "CHRAC1", "CHUK", "CIP2A", "CISD1", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLIC1", "CLIP1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DARS", "DBNL", "DCAF1", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPYSL2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EGFR", "EHD1", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "ELP4", "EMD", "EML4", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "ERCC2", "ERCC3", "ERCC4", "ESD", "ESPL1", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM91A1", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FREM2", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLRX", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIRA", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMGN1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF2", "ILK", "IMPAD1", "IMPDH1", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ITCH", "ITGAV", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KIRREL1", "KLC1", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "LAMB1", "LAMC1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRPPRC", "LRRC59", "LRRC8E", "LRWD1", "LSM2", "LSS", "LTA4H", "LYN", "LZTFL1", "MACF1", "MAD2L1", "MAGT1", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MECR", "MED1", "MEPCE", "MFGE8", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRI1", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVB12A", "MYBBP1A", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "MYO9B", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEU1", "NF1", "NFATC2IP", "NIPBL", "NKRF", "NME1", "NME2", "NME3", "NONO", "NOP2", "NPC1", "NPC2", "NRP1", "NSD1", "NSDHL", "NSF", "NTHL1", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "ORC3", "ORC5", "OTUD7B", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAPSS1", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELO", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PI4K2A", "PIGT", "PIK3C2A", "PIN1", "PISD", "PKM", "PKN1", "PKN2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNP", "PNPT1", "PODXL", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB21", "RAB2A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RECQL5", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF40", "RNMT", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARS", "SASS6", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT1", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPPL2A", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSR3", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STRAP", "STRN", "STUB1", "STX3", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUPT5H", "SURF1", "SUZ12", "SYNE2", "TAB1", "TACO1", "TAF6", "TALDO1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBK1", "TBL1XR1", "TBL2", "TCP1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TLN1", "TMED10", "TMEM165", "TMEM43", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRRAP", "TSC2", "TSG101", "TTC19", "TTC26", "TTI1", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWISTNB", "TXNDC5", "TXNRD1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UCHL5", "UCK2", "UFD1", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VLDLR", "VPS18", "VPS33A", "VPS37B", "VPS4A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR5", "WDR73", "WFS1", "WIPI2", "XAB2", "XPC", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ACACA", "ACACB", "ACOX1", "ACP6", "AFDN", "AGPS", "AHCY", "AHCYL1", "AKT1", "AKT1S1", "AKT2", "ALDH3A2", "ALDH5A1", "ANAPC1", "ANLN", "AP2M1", "APC", "APEX1", "ARHGEF1", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARPC2", "ARPC5", "BAG4", "BAIAP2", "BAX", "BCOR", "C1QBP", "CAMK2G", "CAPN1", "CARM1", "CBFB", "CBL", "CCNA2", "CCNB2", "CDC42", "CDH2", "CDIPT", "CDK2", "CDK4", "CDK5", "CDK9", "CECR2", "CELF1", "CERS2", "CETN2", "CHD1", "CHD3", "CHKA", "CISD1", "CLASP1", "CLTC", "CLUH", "CNN2", "CNP", "COMT", "COPS3", "COX5A", "CPNE1", "CPT2", "CSNK1A1", "CSRP2", "CTPS1", "CTTN", "CYFIP1", "CYFIP2", "CYP51A1", "DCTN4", "DCTPP1", "DDB1", "DDX3X", "DDX5", "DHCR24", "DHCR7", "DHFR", "DICER1", "DNAJC3", "DNMT1", "DSP", "DUSP3", "EIF2B2", "EIF3A", "EIF3B", "EIF3E", "EIF3H", 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"PSMB5", "PSMB7", "PSPH", "PTDSS1", "PTGES2", "PTK2", "QKI", "RAB10", "RAN", "RBM4", "RFC1", "RFC3", "RFC5", "RHOA", "RIPK1", "RPS6", "RRM1", "SCARB1", "SEC24B", "SERINC1", "SERPINH1", "SETD7", "SFPQ", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKP1", "SLC19A1", "SLC25A20", "SLC2A1", "SLC30A7", "SLIT2", "SMARCA1", "SMARCB1", "SMYD3", "SQLE", "SQSTM1", "STAM", "STAT1", "STAT3", "STK4", "STRAP", "STRN", "SULT2A1", "TAB1", "TECR", "TJP2", "TLK2", "TOPBP1", "TOR1AIP1", "TRRAP", "TSC2", "TTC26", "TTI1", "TUBB", "TUBB4A", "TUBGCP3", "UBR5", "USP7", "VIM", "WAPL", "WDR1", "WFS1", "WIPI2", "XPO5", "XRCC1", "XRCC6", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git 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sha256:858f6681dea1d41c2ba43e41d9480dff79ab4eb16b4835f17c787de5ee0ab0bf +size 151319 diff --git a/opencell_localization/consensus.joblib b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f3887b6a69db7dfbfec344bef5c5f14e57a535cf --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d3ec3c38d79412f4079d9d6b2fcce06cbf0377df35f2a3d690c60dc535ef000c +size 67048 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..921c9555e6651bbedb4b66303635f810038b9e04 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 94.05882352941177 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e2a00c0e10f17353f4ba00a5707d9411feb820cd --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fda4e85ba9af7ba8ca2ac1383d761f8fb4c0b54c --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +cell_contact 0.465164784097757 0.8665828110650724 0.3861706349394964 0.9997506495050318 1.0 26 Q9UDY2,P48729,Q9UQB8,O43795,P19022,P22059,P31749 7 +centrosome 0.3308614374820575 0.2519060404558699 0.8011136905136977 0.999999999998808 1.0 33 P17612,P41208,P48729,Q13442,P25054,O43237,Q5SW79,Q9BRK4,O60333 9 +er 0.3056062620249138 0.1400585017061937 0.888613768175752 1.0 1.0 83 Q06136,Q15392,Q16850,Q14739 4 +membrane 0.3006413506265156 0.1256875572843137 0.8999792516026506 1.0 1.0 82 P16333,Q9UQB8,O43795,P22059,P67870,O15127,P41440,P48729,Q15019,P31751,Q15286,Q9BRK4,Q00610,O15144,P25054,Q9NVZ3,P46939,Q99439,P60953,Q68EM7,P31749,Q969E2,Q9H2G2,Q16513,O60499,O15126,P19022 27 +big_aggregates 0.2775379527583625 0.0464142512880378 0.9629800778694624 1.0 1.0 32 Q14997,P62826,Q8IV63,Q9Y5L0,Q92973,Q9BX40,Q96EK5,Q99615,P36404,O60333 10 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a0d66c98214a576826a892ca10d3f0153816668e --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AGAP3", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH9A1", "ALG2", "ANAPC16", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APC", "APLP2", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARPC2", "ARPC3", "ATG3", "ATG4B", "ATG7", "ATL2", "ATL3", "ATP1A1", 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"TOP2A", "TOR1AIP1", "TPR", "TPT1", "TRAPPC11", "TRIM28", "TRIM33", "TRIR", "TRMT1L", "TRRAP", "TSG101", "TSR1", "TSR2", "TTK", "TUBB4B", "TWISTNB", "U2AF2", "U2SURP", "UBA1", "UBA5", "UBE2M", "UBTF", "UFC1", "UPF1", "USP10", "USP7", "UTP14A", "UTP4", "UTP6", "UTRN", "VAPA", "VAPB", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS18", "VPS29", "VPS33A", "VPS35", "VPS37B", "VPS4A", "VRK3", "WAPL", "WBP2", "WDR12", "WDR3", "WDR46", "WDR75", "XPO1", "XPO4", "XPO5", "XPOT", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZNF326", "ZYX"], "leading_proteins": ["AKT1", "AKT2", "APC", "ARHGAP17", "ARL2", "ARPC2", "BAIAP2", "CDC42", "CDH2", "CEP170", "CETN2", "CLTC", "CNN2", "CSNK1A1", "CSNK2B", "CYP51A1", "DHCR24", "DNAJC7", "DYNC1LI2", "KDSR", "KIF1B", "KIFBP", "LBR", "LSM14B", "LZTS2", "MYO1B", "NCK1", "NECAP2", "OSBP", "PDAP1", "PKN2", "PRKACA", "PSME4", "RAB35", "RAN", "SCAMP1", "SCAMP2", "SCAMP4", "SEPT2", "SLC19A1", "SLK", "STX10", "TJP2", "TNPO1", "TNPO3", "UTRN", 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sha256:be7951b9be3399e0b98a409828a6170a9284632a0bb282f82e749e882e3cacdf +size 134628 diff --git a/panther_protein_class/consensus.joblib b/panther_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..bbb351254cdf4f33d9233df11d15ff62d62e8479 --- /dev/null +++ b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b7c27a21ea26a7556eff3335dd612329aa3ad593189704134028a0a61761c697 +size 71090 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..93d0ad1b2fe2125df47043992a61fe333f440831 --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +non-receptor serine/threonine protein kinase 20 49 2.313881271425369 0.0206742357121105 16.135922330097088 52.12621359223301 -0.134221300875087 0.6060262879741318 7.554075018956698 12.250365250469567 0.92962806947858 0.321800658077224 1.0 0.3208622298661138 0.368993499332782 0.6345510601900949 0.1393496660572199 +methyltransferase 3 12 2.145022821627361 0.0319510223539183 3.871359223300971 14.24757281553398 0.1083159719897332 0.5655050447723152 2.576114161276533 2.5612627597162985 0.8801663220809376 0.2923371666369975 1.0 0.1747599807978781 0.3036468889792807 0.060196873958637 0.10824930273491 +cadherin 2 5 1.962289180934736 0.0497288260933528 1.555825242718447 3.0558252427184467 -0.2693089236279177 0.4378099575304214 1.0377767725547085 1.0517161419538543 1.2797396443463749 0.3315735399503712 1.0 1.0 1.0 0.3430049269426823 0.0494682330743412 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..eb40b133f86cdb5b41245e091730ba036b0e5c30 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 159, + "title": "Average number of proteins per term", + "value": 13.19496855345912 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b9ef994e89483f7a6ca69498f1f7c349860b1192 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a943a04ff8253ef8271c01c28f86be77db35c4ee --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,54 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +non-receptor serine/threonine protein kinase 0.4713481977204239 2.313881271425369 0.0206742357121105 0.9639071110642248 0.6920709430349006 49 Q9UHY1,P24941,P17612,P78362,P48729,P50750,Q96KB5,P31751,P78527,Q86UE8,P11802,Q00535,Q13418,P31749,Q9Y4A5,Q8IV63,Q05655,Q15120,Q13555,P42345 20 +methyltransferase 0.734653516704645 2.145022821627361 0.0319510223539183 0.994276317017607 0.6920709430349006 12 P34897,P06132,Q9BV86 3 +G-protein coupled receptor 0.8599017679009204 1.9637740500001155 0.0495563007361878 0.9996907590770504 0.6920709430349006 4 Q5VW38,P48960 2 +cadherin 0.8225026231610645 1.962289180934736 0.0497288260933528 0.9996995575496852 0.6920709430349006 5 Q08554,Q14574 2 +esterase 0.742243751566753 1.7706311965898966 0.0766220506978867 0.9999968714696664 0.6920709430349006 6 Q969T7 1 +DNA-directed DNA polymerase 0.7361943423682262 1.7439743957238438 0.081163554628524 0.9999985715143864 0.6920709430349006 6 P40937,P40938,Q14181 3 +transporter 0.4209560717210362 1.6104571659205442 0.1072980893422448 0.9999999854679186 0.6920709430349006 57 Q8NFH4,O00505,O43772,Q6N075,P39210,O15397,O00410,Q567V2,P41440,Q92973,Q9UI26,Q96P70,Q9HD45,O60684,Q9H2D1,P37198,Q99805,P55060,Q00169,Q92544,Q9Y5L0,O60830,O14617,O14980,Q99595 25 +transferase 0.5506855488555212 1.5598523020621615 0.118794788388409 0.9999999981496578 0.6920709430349006 31 P21266,Q06520,O15217,Q9Y5P6,Q7LGA3,P43490 6 +kinase activator 0.7585839943678574 1.548371650575562 0.1215328426407684 0.99999999887187 0.6920709430349006 4 P46020,O95067 2 +oxygenase 0.6581431387215383 1.5118209306976955 0.1305794232141321 0.9999999997824514 0.6920709430349006 7 Q16850,P30519 2 +histone modifying enzyme 0.5999384060425185 1.4759459042672989 0.1399584149740431 0.9999999999612214 0.7178512251894471 14 Q9H7B4,Q9NRG4 2 +translation initiation factor 0.4256266865224009 1.4482971762400003 0.1475339570614311 0.9999999999905016 0.7330593491489859 44 O75153,Q13144,P60228,Q15056,Q01085,P55884,Q9BY44,Q9ULC4,P49770,Q9NR50,P55010,Q9UI10,O15371,Q7L5N1,Q14152,Q9UBQ5,Q14232,Q9Y3F4,Q86U42,Q92905,O75822,O15372 22 +phosphodiesterase 0.6755365111649096 1.3339091844199702 0.1822336211994699 0.9999999999999872 0.804865160297659 5 O43924 1 +general transcription factor 0.5382440804233619 1.2604255950016066 0.2075158732741131 1.0 0.8627760211547201 24 Q16625,O75448,Q9NPJ6,Q6PD62,Q93074,Q15648,Q14691,Q9Y5Q9,Q9Y6J9,Q9NVC6,P29083 11 +mitochondrial carrier protein 0.5866452534344915 1.177242864628008 0.2390985843608275 1.0 0.8627760211547201 7 Q9BSK2 1 +protease 0.4120088637611768 1.164597656717409 0.2441818927796377 1.0 0.8627760211547201 42 P28074,P28070,P49721 3 +metalloprotease 0.5055519091903803 1.1094212273822175 0.2672485091701375 1.0 0.8938618983932196 26 Q9BYT8,Q9NZ08,Q7Z2K6,O75844,Q9UIQ6,P55786 6 +DNA helicase 0.5272077608422341 1.100470843340557 0.2711270265236496 1.0 0.8938618983932196 10 P18074,P12956,P19447,Q9H4L7 4 +kinase 0.5165724150876311 1.0710929453127185 0.2841276399545047 1.0 0.8938618983932196 20 Q9UBF8,Q9HA64,Q9NVE7,P35790,Q8WVC6,Q9BRR6 6 +calmodulin-related 0.514470726825456 1.025718738137695 0.3050241792890507 1.0 0.9099793349414173 13 P80303,O43852,Q9BRK5,Q15293,Q14257,Q02818 6 +intermediate filament binding protein 0.5800722638628681 0.920962805851213 0.3570698461155095 1.0 0.9752289587744074 5 P15924,Q15149,P58107 3 +protein-binding activity modulator 0.5513889343868359 0.9144489546786002 0.360480988298693 1.0 0.9752289587744074 6 Q9NRX5,O14737 2 +microtubule binding motor protein 0.4898758777472091 0.9021603657285104 0.366971685633997 1.0 0.9752289587744074 17 Q86Y91,Q9UJW0,Q96Q89,Q9BW19,Q02241,O60333 6 +lyase 0.4865868397552159 0.8839497626638463 0.376723332561804 1.0 0.981950981595522 12 Q9UHG3 1 +GTPase-activating protein 0.482981985056694 0.8609809619953518 0.3892485285671752 1.0 0.9982341297125944 14 P49815,P21359 2 +phosphatase modulator 0.5352168759944 0.8428249029994025 0.3993263782127587 1.0 1.0 6 Q9UPN7,P30154 2 +mRNA polyadenylation factor 0.4755410315636405 0.751595169010372 0.4522945494300621 1.0 1.0 8 P33240,Q12996,Q9UNK9,A5YKK6 4 +major histocompatibility complex protein 0.6172311739559331 0.603261870353956 0.5463344943210737 1.0 1.0 3 P10321,P04439 2 +translation factor 0.4552401506055494 0.5773355398105989 0.563712809837591 1.0 1.0 7 Q53EL6,P51114,Q05639,Q06787 4 +DNA glycosylase 0.6007892140743134 0.5492865077472833 0.5828088451356279 1.0 1.0 3 P78549,P29372 2 +reductase 0.3861915352804089 0.5056406496861191 0.6131089396761309 1.0 1.0 31 Q06136,Q15392,Q14739,Q14914 4 +ligase 0.403390026168813 0.5035480186660173 0.6145790286507005 1.0 1.0 25 P11498,P05165,P17812,P22681,Q96RQ3,P50747 6 +DNA metabolism protein 0.3592000020892415 0.4738629843975335 0.6355976166403745 1.0 1.0 36 Q96QE3,P33993,Q12824,Q07864,Q9Y248,P54277,P52701,P18887,Q9NRF9,Q8IWS0 10 +viral or transposable element protein 0.7817225509533197 0.4733664608530117 0.6359517537275201 1.0 1.0 2 Q9H2J4 1 +hydrolase 0.393741806145205 0.4299948139303461 0.6671994136832529 1.0 1.0 22 Q86WA6,O60502,P07099 3 +endoribonuclease 0.5551436243589707 0.4094410197850844 0.6822160418995871 1.0 1.0 3 P78346 1 +homeodomain transcription factor 0.7347140039447667 0.3550257489736944 0.7225703012418911 1.0 1.0 2 O94776 1 +guanyl-nucleotide exchange factor 0.3941582963931602 0.3341516013770915 0.738265163381064 1.0 1.0 7 Q92538,Q92888 2 +chaperone 0.3000836444120316 0.3142559052330335 0.7533266854623715 1.0 1.0 66 Q15813,Q96JJ7,P62942,Q9Y680,O60884,Q7KZN9,Q9NWM8,P78318,O95456,O15260,Q15526,Q8WUA2,Q13526,Q99543,Q15006 15 +RNA helicase 0.3593610449752727 0.2839185617122121 0.7764727914053124 1.0 1.0 13 O60231,Q9H2U1,Q14562,Q92620,O43143,Q6P158,Q8IX18 7 +tubulin 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 1.0 6 P04350,P07437 2 +acyltransferase 0.3545078984012959 0.2651564788274476 0.790888920070087 1.0 1.0 13 P23786,P53611,P49356 3 +replication origin binding protein 0.4944225895091379 0.2528207346256177 0.8004067441886384 1.0 1.0 3 Q9UBD5 1 +exoribonuclease 0.3541011948871028 0.2013610784451424 0.8404162467574634 1.0 1.0 7 Q9GZR2,Q9H0D6 2 +kinase modulator 0.3707236842105379 0.1436474796922974 0.8857788460599987 1.0 1.0 4 P67870,P13861,P54619 3 +pyrophosphatase 0.4222295297599358 0.1217815334368417 0.9030720392649664 1.0 1.0 3 Q9UKK9,Q9H2U2 2 +transcription cofactor 0.3007977485833784 0.1125542869806631 0.9103839283668866 1.0 1.0 9 Q7Z4V5 1 +acetyltransferase 0.2949456517422861 0.0966674537390514 0.9229904869023846 1.0 1.0 9 Q9BXJ9 1 +oxidoreductase 0.2645383690674336 0.0863132894300496 0.9312173744645624 1.0 1.0 40 O14949,Q15067,O95831,O75306,P13804,P48163 6 +kinase inhibitor 0.3406774087471246 0.0472474944923395 0.9623159746325538 1.0 1.0 3 Q96P16,Q9NQG5 2 +ubiquitin-protein ligase 0.236042133135787 0.0404903288561504 0.9677022171749572 1.0 1.0 60 Q92990,O95376,Q12834,Q96PU5,Q15386,O95628,Q5T4S7,O94822,Q9H1A4,O95071,Q96J02,P63208,Q99816 13 +cytoskeletal protein 0.2847747451496275 0.0288647189350643 0.9769724841011012 1.0 1.0 3 Q15019,Q9UHD8 2 +transfer/carrier protein 0.2566386860491312 0.001577659139334 0.9987412106527054 1.0 1.0 12 O15126,O15127,Q969E2 3 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9b1e96904623a2e46131477d0f2902f43cdeca27 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "antimicrobial response protein", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "immunoglobulin receptor superfamily", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "serine/threonine protein kinase receptor", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANGEL1", "ANKFY1", "ANKRD17", "ANKS1A", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOB", "APOBEC3C", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGDIA", "ARHGEF1", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATL2", "ATL3", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG6", "BAIAP2", "BAP18", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCLAF1", "BDH2", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPHL", "BPNT1", "BRCA1", "BRD7", "BRD9", "BRIX1", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX4", "CBX8", "CCAR1", "CCAR2", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2BP2", "CD320", "CD3EAP", "CD47", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKN2AIP", "CDS2", "CEBPZ", "CEP170", "CERK", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIP1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNP", "COA3", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPE", "CPOX", "CPSF1", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CYB5B", "CYB5R3", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DEK", "DENR", "DERL1", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPYSL2", "DPYSL3", "DPYSL5", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC4", "EXOC5", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAHD1", "FAM3C", "FAM98A", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FH", "FKBP14", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GINS1", "GINS2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLT1B", "GOPC", "GOSR1", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "ISCU", "ISOC1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITPA", "ITPK1", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L3HYPDH", "LAMB1", "LAMC1", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTN1", "LYAR", "LYPLA1", "LYPLAL1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED12", "MED17", "MED24", "MED4", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFSD3", "MFSD5", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCK1", "NCOA5", "ND1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NENF", "NEU1", "NF1", "NFS1", "NHP2", "NID1", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NOVA2", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PARG", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHF14", "PHF3", "PHF6", "PHGDH", "PHKA1", "PI4K2A", "PI4KB", "PICALM", 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"PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTB", "RABL6", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIF1", "RIPK1", "RNASEH2A", "RNF14", "RNF2", "RNMT", "RNPS1", "ROCK2", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", 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"SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC38A2", "SLC39A14", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMYD2", "SMYD3", "SNAP23", "SNAP47", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", 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0000000000000000000000000000000000000000..351e953dfbd088288ea374016c53107ff11337ab --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 1988, + "title": "Average number of proteins per term", + "value": 3.1116700201207244 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ec4b9e183b6285d30aa778207a473f98a0dfe4b7 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fdaa1fc3a31d692609c7fa746fa071d72dad013e --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,72 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SET domain 0.893210811010121 2.253351728776204 0.024236980557885 1.0 0.2621581072719435 5 Q9H7B4 1 +Phosphatase modulator 0.744132240662893 2.176552541486861 0.0295139694156434 1.0 0.2621581072719435 9 P55209,Q99733,Q9UPN7 3 +Epigenetic regulator 0.6240241317503938 2.088066828406514 0.0367918068052677 1.0 0.2621581072719435 32 Q9H7B4,Q8NB78,Q9NRG4,Q9BXF3,Q9NPI1,Q9H8M2,Q16637 7 +Protein methyltransferase 0.6906534566365355 1.924816239272511 0.0542523516505581 1.0 0.276878736505733 11 Q9H7B4 1 +Reductase 0.6793051342499864 1.9207409419064876 0.0547643752700477 1.0 0.276878736505733 17 Q15392,Q14739,Q9UBM7,O95881 4 +Cadherin 0.8418410034985202 1.890679626954825 0.0586671236483784 1.0 0.2844640044218935 4 Q14574 1 +Ubiquitin-protein ligase 0.666150601048607 1.8387502951606305 0.0659519220750501 1.0 0.2957675841433376 16 O95376,Q96PU5,O94822,P63208,Q99816 5 +Writer 0.6649330983314733 1.8007748832581618 0.0717383692159088 1.0 0.3040409551469236 12 Q9H7B4,O14744,Q9NRG4,P26358,O60678,Q86X55,Q99873 7 +Protein arginine methyltransferase 0.8105263157894758 1.7628899654521482 0.0779190497906001 1.0 0.3088309652389865 4 Q99873,O60678,Q86X55 3 +Translation initiation factor 0.6367952219258382 1.7430855253594528 0.0813186766055364 1.0 0.3124211106714584 20 O75153 1 +Phosphatase inhibitor 0.7335972747391182 1.7325124451926888 0.0831823631948287 1.0 0.3155849962429762 6 P55209,Q99733 2 +Methyltransferase 0.6374771749874113 1.6601073040793983 0.0968928678006035 1.0 0.3427455893017792 11 P34897,Q9BV86 2 +Bromodomain 0.6591781492279299 1.6393224188619269 0.1011461293985629 1.0 0.3479089183284584 8 Q9H8M2,Q9NPI1 2 +Atypical group 0.8776718184807604 1.5651273079196335 0.1175530616860114 1.0 0.3655006339779612 3 P42345,P78527 2 +CK1 group 0.8752440258349694 1.555928358344337 0.11972512912262 1.0 0.3695862681611313 3 P48729 1 +SLC superfamily of solute carriers 0.4029012767030379 1.543161478343332 0.1227916012395002 1.0 0.3740503229334164 47 P41440,O43772,Q9Y6C9,Q6N075,Q9H2D1,Q96NB2,O75746,Q8NEW0,O43808,Q7L0J3,Q9BSK2,Q8IXU6 12 +Translation factor 0.5650932429560853 1.4717067888737525 0.1411000735416721 1.0 0.404559809925597 26 O75153 1 +SLC25 family of mitochondrial transporters 0.5785432306460145 1.4191880226263751 0.155844206919002 1.0 0.4178824414777079 20 O43772,Q9Y6C9,Q9H2D1,O43808,Q9BSK2 5 +Mitochondrial nucleotide transporter subfamily 0.5888817341670429 1.418505457693226 0.1560432464182417 1.0 0.4178824414777079 9 Q9BSK2,O43808 2 +Cell adhesion 0.6265851909579019 1.3645879112079056 0.1723826064084685 1.0 0.4382309738363625 7 Q14574 1 +Kinase activator 0.6653813282369134 1.2897775827162687 0.1971278934589093 1.0 0.4682081866144704 5 O95067 1 +CDK family 0.5738511910002217 1.226450617565409 0.2200291478275637 1.0 0.496035928526745 8 P11802,P50750,P24941 3 +Tight junction 0.7790012110844752 1.1903256871549384 0.2339184084469148 1.0 0.5138450784447145 3 Q16625 1 +Cell-cell junction 0.7790012110844752 1.1903256871549384 0.2339184084469148 1.0 0.5138450784447145 3 Q16625 1 +Receptor 0.4995810831363994 1.154007241190802 0.2484972002028569 1.0 0.5294213648091345 29 P57105,Q567V2,A6NIH7,Q9UQB8,P39210,Q9ULC4 6 +Intracellular calcium-sensing protein 0.530187072877688 1.1104687794836805 0.2667970743082157 1.0 0.5519173607957679 15 P80303,P60660,O43852,Q9BRK5,Q15293,Q14257,Q02818 7 +Calmodulin 0.530187072877688 1.1104687794836805 0.2667970743082157 1.0 0.5519173607957679 15 P80303,P60660,O43852,Q9BRK5,Q15293,Q14257,Q02818 7 +Reader 0.5132956907120637 1.0193427123488068 0.3080402930502681 1.0 0.5951930736224245 14 Q9H8M2,Q9BXF3,Q9NPI1 3 +Calcium-binding protein 0.5024967175144468 0.9756728521054816 0.329226609598118 1.0 0.6134044047620042 18 P80303,P60660,O43852,Q9BRK5,Q15293,Q14257,Q02818 7 +G-protein coupled receptor 0.9408284023668632 0.9614079320876524 0.3363470975414633 1.0 0.6222267355877055 2 P48960 1 +Endoribonuclease 0.5888245824487637 0.9583720008014472 0.3378752087516017 1.0 0.6225170667267694 5 O95639 1 +Acyltransferase 0.5114396987557411 0.9228981750866778 0.3560602717346479 1.0 0.6418217487139538 8 P49356 1 +Intermediate filament binding protein 0.5800722638628681 0.920962805851213 0.3570698461155095 1.0 0.6418217487139538 5 P15924,Q15149,P58107 3 +Intermediate filament 0.5800722638628681 0.920962805851213 0.3570698461155095 1.0 0.6418217487139538 5 P15924,Q15149,P58107 3 +Microtubule binding motor protein 0.4850509572210228 0.8731766801964694 0.3825667834979038 1.0 0.6624936982524676 13 Q86Y91,Q96Q89,Q02241,Q9BW19 4 +Metalloprotease 0.4033062939879863 0.8530422109406529 0.3936358964904887 1.0 0.674029424826091 38 Q9BYT8,Q9NZ08,Q7Z2K6,O75844,Q9UIQ6,P55786 6 +Extracellular matrix glycoprotein 0.5621103902865674 0.8447947770838643 0.3982254312310542 1.0 0.6778015045268286 5 Q32P28 1 +PIKK family 0.8980933596318198 0.8210674961697286 0.411607823113949 1.0 0.690528567384414 2 P42345 1 +Ligase 0.3661423281456642 0.782501110790132 0.4339201328118056 1.0 0.7135096972951774 70 O95376,P11498,O43776,P05165,Q9NP81,P22681,Q15046,Q96PU5,Q96RQ3,O94822,Q5JPH6,Q96J02,P50747,P63208,Q99816 15 +AKT family 0.8856015779092808 0.7810096647412119 0.4347968104040842 1.0 0.713770486443699 2 P31751 1 +DNA helicase 0.4645180478524647 0.7719547911842987 0.4401412040403505 1.0 0.7183913905026411 12 P28370,P33993,Q9H4L7,P12956 4 +V-type ATPase 0.4750535840606781 0.6634164420369042 0.5070638783659009 1.0 0.7671560047118805 7 Q93050,Q9Y487 2 +Oxygenase 0.4733034143289594 0.5784920649888442 0.5629319531134218 1.0 0.8036840280320833 6 Q16850 1 +Protein kinase 0.3264543080591374 0.5153606532946831 0.6063010222053153 1.0 0.8319147917645566 66 Q9UHY1,P24941,P17612,P78362,P48729,P50750,Q96KB5,P31751,P78527,Q05397,Q86UE8,P11802,Q00535,Q13418,P31749,Q8IV63,Q05655,P46020,Q15120,Q13555,P42345 21 +Helicase 0.4083588003948871 0.5097161660523987 0.6102503256387461 1.0 0.833624855485438 23 P28370,P33993,P49736,Q7Z478,Q14562,O43143,Q92620,P12956,P42694,P33991,Q6P158,Q9H4L7,Q8IX18 13 +Dehydratase 0.5755334764178894 0.4699129161391093 0.6384172359593627 1.0 0.8523799675331716 3 P61457 1 +CMGC group 0.3998709034609293 0.4463190777554826 0.6553667774022791 1.0 0.8622562233459503 16 P78362,P24941,P11802,P50750,Q00535 5 +Protease inhibitor 0.3976757948824943 0.4414693717142585 0.6588732301460329 1.0 0.8651519032564817 14 Q5ZPR3,P50452 2 +Transcription cofactor 0.3934809762102865 0.4389106566459267 0.6607262747332276 1.0 0.8652669299183725 11 O60828,O00625,Q8NI27,Q93074 4 +Other group 0.3932609097346552 0.4314346018300362 0.6661523949667236 1.0 0.8678315604153648 12 Q86UE8 1 +Signaling 0.3891412128167754 0.3977277738900028 0.690830862178565 1.0 0.8849851876601467 16 P43490,Q99627 2 +RNA helicase 0.3719736743214712 0.3468103771577069 0.7287337806007386 1.0 0.899827798654825 11 Q14562,Q92620,O43143,Q8IX18,Q6P158,P42694 6 +Microtubule family cytoskeletal protein 0.2875402184841482 0.307187149862687 0.7587009259164939 1.0 0.9136351386194752 44 P04350,O43663,Q86Y91,Q96Q89,Q9BW19,Q96CW5,Q15555,Q02241 8 +mRNA splicing factor 0.2835725430464883 0.3034166205817881 0.7615723809282924 1.0 0.9136351386194752 59 O43172,Q01844,Q9BZJ0,P98179,P08621,P33240,P35637,Q9BWF3,O60508,O75533,Q8IY67,Q92804,P62995,Q07666,Q15233,O43809,P23246,Q14011,Q96PU8 19 +SRPK family 0.6998685075608315 0.2784464371856097 0.7806696766277235 1.0 0.9170001197820395 2 P78362 1 +Tubulin 0.3917314526277053 0.2773497340136845 0.7815115745463674 1.0 0.9170001197820395 6 P04350,P07437 2 +Replication origin binding protein 0.4944225895091379 0.2528207346256177 0.8004067441886384 1.0 0.9192359664185928 3 Q9UBD5 1 +Histone deacetylase 0.4863531732982421 0.2350257941397954 0.8141887130471805 1.0 0.9192359664185928 3 Q13547,Q96EB6 2 +Unclassified protein 0.3476138263308446 0.22365580055859 0.8230251407301181 1.0 0.9203607484255252 19 Q9HA64,Q9BRR6,Q4G0N4 3 +Dehydrogenase 0.2605955835690792 0.19556344220662 0.844951876592253 1.0 0.9203874965480152 56 P00390,Q14914,O95831,P28331,P50213,O75306,P30837,Q9NZ01,Q8N335,P03886 10 +Protein phosphatase 0.3266438353867459 0.1844473212827808 0.8536625495645196 1.0 0.9203874965480152 10 P63151,P30153,P30154 3 +Glycosylase 0.6153846153846122 0.1381742871737468 0.8901026760145438 1.0 0.9268354773588756 2 P78549 1 +DNA glycosylase 0.6153846153846122 0.1381742871737468 0.8901026760145438 1.0 0.9268354773588756 2 P78549 1 +Pyrophosphatase 0.4222295297599358 0.1217815334368417 0.9030720392649664 1.0 0.9304222362142942 3 Q9UKK9,Q9H2U2 2 +Kinase modulator 0.3128780241902014 0.1162124299563994 0.9074841858212304 1.0 0.9307748449797354 15 P20248,Q9UBW7,Q92616,Q2TAL8,O95067 5 +Non-protein kinase 0.305519412693565 0.0885149629918276 0.9294673922701456 1.0 0.9461245139954172 18 P35790 1 +Translation elongation factor 0.3130213524002767 0.0602690767483205 0.9519413303394876 1.0 0.96554049220148 4 Q53EL6,P29692 2 +Acetyltransferase 0.2928544269585777 0.0553292663465229 0.9558761466984598 1.0 0.9690371135321458 19 P23786,Q9H9T3,Q9BXJ9,P11182 4 +STE7 family 0.4746877054569212 0.0388280256272897 0.969027500458112 1.0 0.9815913430917352 2 Q02750 1 +G-protein 0.2719102643875908 0.020207329470167 0.9838779810087293 1.0 0.99387674097833 29 P62826,Q6DD88,P61586,Q9NTK5,Q15019,P60953,Q8IXI1,Q9UI26,O75616,Q96P70,O15397,P55060 12 +mRNA processing factor 0.2509471399750474 0.0020740048534585 0.9983451847347588 1.0 1.0 74 O43172,Q01844,Q9BZJ0,P98179,P08621,P33240,P35637,P57081,Q9BWF3,O60508,O75533,Q8IY67,Q92804,P62995,Q07666,Q15233,Q9C0J8,O43809,P23246,Q14011,Q96PU8 21 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b56f3c6e01d9b51563e550c0b066aa5f96eaac05 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AK1 subfamily", "AK2 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family D member 4", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent DNA helicase Q5", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Abl interactor 1", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acid sphingomyelinase-like phosphodiesterase 3a", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Activin receptor type-1b", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Adenylyl cyclase-associated protein 2", "Adhesion class", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Anion exchange protein 2", "Anion exchangers", "Ankyrin repeat and SAM domain-containing protein 1A", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 1", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis regulator BAX", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atlastin-3", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical SLC22B subfamily", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Beta-mannosidase", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, cytosolic", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "Bromodomain-containing protein 7", "Bromodomain-containing protein 9", "Butyrophilin subfamily 2 member A1", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CAP-Gly domain-containing linker protein 1", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 4", "CD166 antigen", "CD2 antigen cytoplasmic tail-binding protein 2", "CD276 antigen", "CD97 antigen", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDK9 subfamily", "CDKN2A-interacting protein", "CHK1 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium-regulated heat-stable protein 1", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calpain-5", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Caspase-2", "Caspase-3", "Cat eye syndrome critical region protein 2", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cathepsin B", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division control protein 45 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell division cycle protein 20 homolog", "Cell surface glycoprotein MUC18", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Ceramide glucosyltransferase", "Ceramide kinase", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 5", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 4", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Copper-transporting ATPase 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-A2", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 9", "Cyclin-dependent-like kinase 5", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytokine receptor", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA dC->dU-editing enzyme APOBEC-3C", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase alpha subunit B", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA repair endonuclease XPF", "DNA repair protein complementing XP-C cells", "DNA replication complex GINS protein PSF1", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyribonuclease-2-alpha", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmocollin-1", "Desmocollin-2", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 4", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase CBL", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase MARCH5", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase RNF14", "E3 ubiquitin-protein ligase listerin", "EGFR family", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER lumen protein-retaining receptor 3", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endonuclease III-like protein 1", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelial protein C receptor", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 4", "Exocyst complex component 5", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FAK family", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Focal adhesion kinase 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "G2/mitotic-specific cyclin-B2", "GDP-L-fucose synthase", "GDP-mannose 4,6 dehydratase", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit beta", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamine-rich protein 1", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "H/ACA ribonucleoprotein complex subunit 3", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Heparanase", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone chaperone ASF1B", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase EHMT2", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SETD7", "Histone-lysine N-methyltransferase SMYD3", "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Huntingtin-interacting protein 1", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "ILK subfamily", "INSR family", "ITPK1 family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit alpha", "Inhibitor of nuclear factor kappa-b kinase subunit beta", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Inositol polyphosphate 5-phosphatase OCRL-1", "Inositol-tetrakisphosphate 1-kinase", "Insulin-degrading enzyme", "Insulin-like growth factor 1 receptor", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon gamma receptor 1", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KHS subfamily", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF18B", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF1B", "Kinesin-like protein KIF20B", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kinetochore protein Nuf2", "Kynurenine--oxoglutarate transaminase 3", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lactadherin", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Laminin subunit gamma-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Leukocyte elastase inhibitor", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAP7 domain-containing protein 1", "MAPK family", "MAST family", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "Mediator of RNA polymerase II transcription subunit 12", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma-associated antigen D2", "Membralin", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Methyltransferase-like protein 7A", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitogen-activated protein kinase kinase kinase kinase 5", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "Myotubularin-related protein 6", "N-acetyl-D-glucosamine kinase", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 50", "N-lysine methyltransferase SMYD2", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neurofibromin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-14", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase 3", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "OTU domain-containing protein 4", "OTU domain-containing protein 7B", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 3", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 14", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PITSLRE subfamily", "PKA family", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "PMS1 protein homolog 1", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Paxillin", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-glycine alpha-amidating monooxygenase", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphatidylserine synthase 2", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylase b kinase regulatory chain family", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Phosphorylated adapter RNA export protein", "Phosphoserine phosphatase", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl 3-hydroxylase 3", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FAM177A1", "Protein FRG1", "Protein HIRA", "Protein LSM14 homolog B", "Protein Mpv17", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein VAC14 homolog", "Protein Wiz", "Protein angel homolog 1", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c delta type", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein Nova-2", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-alpha serine/threonine-protein kinase", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related GTP-binding protein C", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Ras-related protein Ral-B", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Remodeling and spacing factor 1", "Renin receptor", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC22 family of organic cation and anion transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC64 Golgi Ca2+/H+ exchangers", "SLC7 family", "SLC9 family of sodium/hydrogen exchangers", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "STKR Type 1 subfamily", "STKR family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sal-like protein 2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Secretory carrier-associated membrane protein 4", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Separin", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine incorporator 1", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 26", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase chk1", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase greatwall", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase tbk1", "Serine/threonine-protein kinase tousled-like 2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin B8", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sialidase-1", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal peptide peptidase-like 2A", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-coupled neutral amino acid transporter 2", "Sodium-dependent HCO3- transporters", "Sodium/hydrogen exchanger 6", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 9", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 2, facilitated glucose transporter member 4", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sortilin-related receptor", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 1", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptic vesicle glycoprotein 2A", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 47", "Syntaxin-10", "Syntaxin-12", "Syntaxin-18", "Syntaxin-3", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TLK family", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Terminal uridylyltransferase 4", "Testin", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thyroid adenoma-associated protein", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1B", "Trafficking protein particle complex subunit 4", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription initiation factor TFIID subunit 6", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 165", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Trophoblast glycoprotein", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tuberin", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Type II PI4K subfamily", "Type II cytokine receptor", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase lyn", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm3", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UDP-glucuronic acid decarboxylase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 33", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin conjugation factor E4 B", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "YSK subfamily", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7B", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter 7", "Zinc transporter ZIP14", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG12", "ALYREF", "ANAPC1", "ANGEL1", "ANKS1A", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOBEC3C", "APOL2", "APP", "ARCN1", "ARFIP1", "ARHGDIA", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BAX", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCLAF1", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD9", "BRIX1", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2BP2", "CDC20", "CDC37", "CDC40", "CDC42", "CDC45", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKN2AIP", "CEBPZ", "CECR2", "CEP170", "CERK", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHKA", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIP1", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCPS", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DICER1", "DIDO1", "DIS3", "DLD", "DLGAP5", "DLST", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP3", "DPYSL2", "DPYSL3", "DPYSL5", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHA7", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC4", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC4", "EXOC5", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "FAHD1", "FAM177A1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXRED1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GCAT", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GINS2", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GOSR1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GTF3C3", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HPSE", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "LAMB1", "LAMC1", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM3", "LSM6", "LTN1", "LYN", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4K5", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MASTL", "MAT2A", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED12", "METTL1", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL9", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "ND1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS7", "NEDD4L", "NEK9", "NEU1", "NF1", "NFS1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NOVA2", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OLA1", "OPA1", "ORC3", "ORC5", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PHKA1", "PI4K2A", "PI4KB", "PICALM", "PIGK", "PIK3C2A", "PINX1", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNP", "PNPT1", "POGZ", "POLA2", "POLD2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKAG1", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PROCR", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PSPH", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PUS1", "PWP1", "PXN", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTB", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RALB", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIPK1", "RNASEH2A", "RNF14", "RNH1", "RNPS1", "ROCK2", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "SAE1", "SALL2", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD7", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMPDL3A", "SMYD2", "SMYD3", "SNAP23", "SNAP47", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SORL1", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPPL2A", "SPTLC1", "SPTLC2", "SQLE", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK26", "STK4", "STOML2", "STRBP", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TAP1", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TLK2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM165", "TMEM259", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM3", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TROVE2", "TSC2", "TSFM", "TSG101", "TST", "TSTA3", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UBE4B", "UCHL5", "UCK2", "UGCG", "UGGT1", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP28", "USP33", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP3", "UTP6", "UXS1", "VAC14", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VRK1", "VRK3", "WARS", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR82", "WIZ", "XAB2", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7B", "ZCCHC11", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF281", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ADGRE5", "ADPGK", "AIFM1", "AKT1", "AKT2", "ALDH1B1", "ARIH2", "ATL3", "ATP6V0A1", "ATP6V0A2", "BAIAP2", "BRD7", "BRD9", "CALU", "CAMK2G", "CARM1", "CBL", "CCNA2", "CCNB2", "CD276", "CDC40", "CDC42", "CDK2", "CDK4", "CDK5", "CDK9", "CECR2", "CHKA", "CIRBP", "CLUH", "COPS8", "CPSF4", "CPT2", "CRNKL1", "CSE1L", "CSNK1A1", "CSTF2", "CYP51A1", "DBT", "DHCR24", "DHCR7", "DHX15", "DHX29", "DHX38", "DHX40", "DHX57", "DHX8", "DNMT1", "DSC3", "DSP", "EARS2", "EEF1D", "ELP3", "EPPK1", "ERAL1", "ERAP1", "ERMP1", "EWSR1", "FN3KRP", "FNTB", "FUS", "GCN1", "GPD1L", "GSR", "HDAC1", "HELZ", "HLCS", "IDH3A", "ILK", "IPO11", "IPO8", "IPO9", "ITCH", "KARS", "KDM1B", "KHDRBS1", "KIF18B", "KIF20B", "KIF23", "KIFC1", "LBR", "LNPEP", "LTN1", "MAP2K1", "MAPRE2", "MCCC1", "MCM2", "MCM4", "MCM7", "MCTS1", "MED12", "MFSD5", "MPV17", "MPV17L2", "MTCH2", "MTOR", "MYL6", "NAA15", "NADK2", "NAMPT", "NAP1L1", "NAP1L4", "NARS", "ND1", "NDUFS1", "NDUFS2", "NEDD4L", "NLN", "NONO", "NPEPPS", "NRBP1", "NTHL1", "NTMT1", "NUCB1", "NUCB2", "NUDT21", "NUDT5", "OCLN", "OLA1", "ORC3", "P3H1", "PBK", "PC", "PCBD1", "PCCA", "PDCD4", "PDK3", "PHKA1", "PIR", "PLEC", "PPA2", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP6R1", "PQBP1", "PRC1", "PRKACA", "PRKCD", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF4", "PTGR1", "PTK2", "QKI", "QRICH1", "RAN", "RAVER1", "RBM3", "RBM4", "RCN1", "RCN2", "RHOA", "RHOT2", "SARS2", "SDF4", "SEPT2", "SERPINB8", "SF3B1", "SFPQ", "SFXN2", "SHMT2", "SIRT1", "SKP1", "SLC19A1", "SLC25A12", "SLC25A17", "SLC25A20", "SLC25A32", "SLC25A33", "SLC30A7", "SLC35F2", "SMARCA1", "SMARCAD1", "SMN1*", "SMYD2", "SMYD3", "SNRNP70", "SRPK2", "SV2A", "SYNJ2BP", "TAF15", "TECR", "THOC2", "TLK2", "TRA2B", "TSG101", "TUBB", "TUBB4A", "TUBGCP3", "TXNDC12", "UNC119B", "VRK3", "WDR33", "WDR4", "XRCC6", "ZMPSTE24", "ZMYM2"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a0d1d19f0013ef4b131cc6a830dfee60c4c6f893 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d3e9bd470669e421c893c7cf66cac3232ffb53d93b113cee398b4480a5871880 +size 138789 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4307b7936293b20a8aadb1aa9e608d43b010116c --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6343c80eb501a255a489d63865cfc0ca681d7fdc15e630a4f0739ffd461a4e90 +size 75796 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3731b26a47f45f30eea42cd7e904dfb52e047925 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 760.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..89f9132b1a3a5e9e7c2f11ad6193292f198ef899 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3ae913bad22e7862f3052437e31eb6e92ab8fa4e --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.318360262526087 0.196486257034688 0.8442295883135873 0.999411237865918 1.0 84 P04350,P48735,P49721,P28074,P20618,P00390,Q07864,P26358,P28331,Q99720,Q7L0J3,P03886,O43924,P25786,P11802,O75306,Q86Y39,Q05655,P42345 19 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..62b716c4de022f4c94271a691b9d8db6ce873d6f --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRI3BP", "BRIX1", "BROX", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C14orf2", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC25", "CCDC47", "CCDC6", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPI", "CENPM", "CENPV", "CEP170", "CEP290", "CEP44", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM136A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM234B", "FAM3C", "FAM49B", "FAM50A", "FAM83D", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLM2", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KLHDC4", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZIC", "LZTFL1", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRFAP1", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHLRC2", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM160", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM206", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM43", "TMEM59", "TMEM87A", "TMEM9", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSR2", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR73", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", 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"signature_size": 3044, + "annotations_size": 167, + "title": "Average number of proteins per term", + "value": 29.461077844311376 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..771e142decf87d8bca967b6fc937b1f693eaa80b --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..90fa882c096917c7d36aba7bd839fa53380741ee --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,50 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lipid biosynthesis 0.5904885171149147 3.2765650752676194 0.0010507809483699 0.161023580803165 0.1754804183777846 47 Q9NRX5,Q15392,Q14739,P11498,Q96G23,O00763,Q9NZ01,P35790,Q13085,Q16850,Q9UBM7 11 +Cholesterol biosynthesis 0.7760331753166206 2.3435493735047577 0.0191012338908167 0.9600755047756596 0.5316510099610662 12 Q15392,Q16850,Q14739 3 +Sterol biosynthesis 0.7760331753166206 2.3435493735047577 0.0191012338908167 0.9600755047756596 0.5316510099610662 12 Q15392,Q16850,Q14739 3 +Steroid biosynthesis 0.6706187097446543 1.8620107950450533 0.0626015686301406 0.9999795192834124 0.904061655866094 16 Q15392,Q16850,Q14739 3 +Angiogenesis 0.6561416766444979 1.7565464722000057 0.0789951436207392 0.999998924177375 0.904061655866094 12 Q05397,Q12948 2 +Steroid metabolism 0.584106721521176 1.586862190520825 0.1125438598402563 0.9999999978095564 0.9892012943854116 26 Q15392,Q14739,Q06520,Q16850,Q9UBM7 5 +Fatty acid biosynthesis 0.5911436689513677 1.4264208569160497 0.1537468968154782 0.9999999999992192 1.0 13 Q13085,O00763 2 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0.9992520958429424 0.3176725850333062 1.0 1.0 11 P35790 1 +Cilium biogenesis/degradation 0.4989957298937872 0.9450127655005284 0.3446523588808743 1.0 1.0 15 O95684,A6NIH7 2 +Glyoxylate bypass 0.9309664694280086 0.9286243310618104 0.3530838079415046 1.0 1.0 2 P48735 1 +Glucose metabolism 0.4618060175744304 0.7698817280462776 0.4413700535621156 1.0 1.0 10 P31751,P31749 2 +RNA-mediated gene silencing 0.4570669057519446 0.7271682624825628 0.4671228857695186 1.0 1.0 16 A5YKK6,Q92841,Q06787,Q9BWF3,Q92600,Q9UPY3,Q9HAV4,Q9HCE1,Q09161 9 +One-carbon metabolism 0.4498411552349116 0.7108844944298812 0.4771558152500914 1.0 1.0 10 O43865,P34896,P34897 3 +Chemotaxis 0.6317000986517536 0.6520594744963448 0.5143628058915972 1.0 1.0 3 P09429,O94813 2 +Biological rhythms 0.3597859978056391 0.6306507455382638 0.5282689108735257 1.0 1.0 40 O14744,Q96EB6,Q96ST3,Q13148,Q13330,Q9Y2K7,P17844,Q93008,Q16531,Q00535,P23246,Q93009,P42345,P78527,P43490,Q15233 16 +Zinc transport 0.8310322156476155 0.6128475457124967 0.5399771495311765 1.0 1.0 2 Q8NEW0 1 +Immunity 0.3555487617147279 0.6120915345977986 0.5404771981051837 1.0 1.0 74 O14802,P17812,Q9UQ84,Q07021,Q9H2U1,Q9NZ08,Q9BUI4,P78527,P25786,O00571,Q9Y3Z3,P14174,Q7Z434,Q9BWS9,Q6GQQ9,Q96FW1,O95801,O60828,P12956,O00743 20 +GMP biosynthesis 0.6125074809171718 0.5875858889622845 0.5568102848742158 1.0 1.0 3 P49915 1 +Exocytosis 0.4188519349847047 0.5486393626595535 0.5832529670023141 1.0 1.0 12 Q96A65,Q96KP1,Q9BRK5,Q15334,Q9UPT5 5 +DNA replication 0.2919129311438513 0.5457943398876601 0.5852073144310204 1.0 1.0 49 P33993,P49005,Q9Y248,Q07864,P31350,Q14181,P40937,Q9UFC0,P23921,P35251,P27694,Q14691,O43913,P51530,Q9Y3Z3,Q9BRT9,Q9UBD5,P33991,P40938 19 +Unfolded protein response 0.4311146590398406 0.4766366583751049 0.6336208747293297 1.0 1.0 7 Q2TAL8,Q13217,Q92575 3 +Lipid degradation 0.4028331801293843 0.4691215843408904 0.6389827316920669 1.0 1.0 13 Q06520,Q9H6V9 2 +Adaptive immunity 0.3869466164293365 0.3903449381878016 0.6962814976941658 1.0 1.0 15 Q6GQQ9,Q96FW1,Q9NZ08 3 +Methionine biosynthesis 0.5458658034126264 0.3831211416102681 0.7016299446633671 1.0 1.0 3 Q99707 1 +Nonsense-mediated mRNA decay 0.3753512480445631 0.3440794771906821 0.7307865164991232 1.0 1.0 14 Q9HAU5 1 +Antiviral defense 0.3663397766097023 0.3145815100100095 0.7530794197821833 1.0 1.0 24 O14802,Q13217,Q9H2U1,P42224,Q9BUI4,Q9NUD5,O95801,Q9Y3Z3,Q7Z434,Q7Z7L1,Q96J02 11 +Sugar transport 0.4401188051165492 0.3108653058543805 0.7559030205044457 1.0 1.0 4 P31751 1 +Innate immunity 0.2819458351439707 0.3071164264626904 0.7587547550066753 1.0 1.0 58 Q14166,O14802,Q96J02,Q9NUD5,Q07021,Q9H2U1,Q9BUI4,P78527,P10321,O00571,Q9Y3Z3,P14174,Q7Z434,Q15233,Q9BWS9,P12956,O95801,O60828,O00743,P23246 20 +Neurogenesis 0.2992513181703483 0.3043246749010836 0.760880548250892 1.0 1.0 42 P48681,Q96EK5,Q12834,Q12824,P43034,Q00535,O14497,Q16352,Q9H9T3,P60953,Q7L576,P55209,Q16637,Q13555,P31749 15 +Wnt signaling pathway 0.3616610724529812 0.2795589565101978 0.7798158998871756 1.0 1.0 20 P25054,P48729,Q6PD62,Q9GZS3,Q9BRK4,Q9NPI1 6 +Chromosome partition 0.3126005648935586 0.1070033315089103 0.9147863367698416 1.0 1.0 19 Q8NFH4,P18074,O00571,Q9Y6X3,Q8NFH3 5 +Oogenesis 0.5851413543721152 0.1040365562427565 0.917140338277701 1.0 1.0 2 Q15645 1 +ER-Golgi transport 0.2304490536984348 0.092482115815323 0.926314999832323 1.0 1.0 47 P24390,Q9Y282,O43731,O95070,O95487,P53621,P53992,Q6NUQ1,P35606,P62820,Q9HCU5,Q7Z392 12 +tRNA processing 0.2946885399759672 0.0650608696733787 0.9481255358689848 1.0 1.0 26 Q9H9T3,Q9BQ52,P57081,Q99575 4 +Differentiation 0.2854413022364827 0.054314612515673 0.9566845076346786 1.0 1.0 83 Q13642,Q16352,Q96TC7,P78362,A1X283,P43034,Q9H2U1,Q9BWF3,Q8NB90,Q16527,Q14997,Q4G0J3,Q99829,Q96PU5,P60953,Q7L576,Q96EK5,Q9BXJ9,Q12834,O43809,Q13555,Q96PU8 22 +Tricarboxylic acid cycle 0.2867017433878287 0.0405157459023976 0.9676819539338776 1.0 1.0 20 P50213,P48735 2 +Branched-chain amino acid catabolism 0.4743589743589665 0.0387394513535451 0.9690981193718956 1.0 1.0 2 Q6NVY1 1 +Prostaglandin biosynthesis 0.4694280078895368 0.0374638726968746 0.9701151453243256 1.0 1.0 2 Q9H7Z7 1 +Cell shape 0.2744674856812386 0.0221812399080733 0.982303382294271 1.0 1.0 6 Q7L576 1 +Respiratory chain 0.2698606785097532 0.0192020658355275 0.9846799096090142 1.0 1.0 30 P31930,O14949,O43676,Q6DKK2,P28331,O75306,Q86Y39,O95299,Q96CU9,Q9UDW1,Q9P0J0,P03886 12 +Necrosis 0.2484369858506163 0.0067074066247012 0.994648303939334 1.0 1.0 5 Q13546,P04637,Q96HS1,O00429 4 +DNA condensation 0.2478530241358316 0.0064170599198404 0.9948799621036182 1.0 1.0 5 Q15003,Q15021 2 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5a0de40cdcb6151e5f2381c9e4b392202667d35b --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Anion exchange", "Antiport", "Antiviral defense", "Apoptosis", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Bile acid catabolism", "Biological rhythms", "Biomineralization", "Blood coagulation", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Hemostasis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubl conjugation pathway", "Unfolded protein response", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACAT1", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADGRE5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEX1", "API5", "APOB", "APOBEC3C", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL8B", "ARMT1", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "AUP1", "AURKA", "BABAM1", "BAG3", "BAG6", "BANF1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BIRC6", "BMS1", "BOP1", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C2CD5", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CAMK2G", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARM1", "CARS", "CASP2", "CASP3", "CBL", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC23", "CDC27", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDS2", "CDYL", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP290", "CEP55", "CERS1", "CERS2", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLIC1", "CLINT1", "CLIP1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "COG7", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPZ1", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CREG1", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CXADR", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCP2", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDA1", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPY30", "DPYSL2", "DSC1", "DSC2", "DSC3", "DSG2", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EGFR", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMG1", "EML4", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM50A", "FAM83D", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCC2", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GHITM", "GINS1", "GINS2", "GINS3", "GINS4", "GLRX", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPHN", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSS", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP10", "GTPBP4", "GYS1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HERC2", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HPSE", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILVBL", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS13", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRF2BP1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD5", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18B", "KIF1B", "KIF20B", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LAMB1", "LAMC1", "LAMP1", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDLR", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LRP1", "LRP2", "LRPPRC", "LRRC8E", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAP1S", "MAP2K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MESD", "METTL1", "MFGE8", "MFSD3", "MFSD5", "MFSD8", "MGEA5", "MGST2", "MIA3", "MICU1", "MID1", "MIF", "MINDY3", "MKI67", "MMGT1", "MMS19", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MRC2", "MRE11", "MRI1", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVB12A", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCK1", "NCKAP1", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NEU1", "NFS1", "NHP2", "NID1", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NMD3", "NME1", "NME2", "NME3", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP10", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NTHL1", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PANK4", "PARG", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLIN3", "PLK1", "PLRG1", "PMS1", "PMVK", "PNN", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POP1", "PPAT", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAG1", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTK2", "PTK7", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PWP1", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB35", "RAB39A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALY", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RARS2", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCOR1", "RECQL5", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN3", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNMT", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SEPT9", "SERINC1", "SERPINH1", "SET", "SETD1A", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SMYD2", "SNAP23", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SORL1", "SORT1", "SPATA5", "SPC24", "SPC25", "SPECC1L", "SPEN", "SPOUT1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SRFBP1", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STK26", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "TACC3", "TACO1", "TAF6", "TAF6L", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBCB", "TBK1", "TBL1XR1", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TDP2", "TDRKH", "TECR", "TENM3", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TK1", "TLK2", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM206", "TMEM214", "TMEM30A", "TMEM59", "TMEM9", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSNAX", "TSR1", "TSR2", "TTC19", "TTC26", "TTC4", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWISTNB", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAC14", "VAMP7", "VAPA", "VAPB", "VARS1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VLDLR", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WBP11", "WDR12", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "XAB2", "XPC", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZMYM2", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ACACA", "ACACB", "ACP6", "AHCYL1", "AKT1", "AKT2", "APC", "ARID1A", "BRD7", "C1QBP", "CAMK2G", "CDC20", "CDC42", "CDK5", "CERS2", "CHID1", "CHKA", "CNOT1", "CNOT9", "COPA", "COPB2", "CPNE1", "CREG1", "CSNK1A1", "CSRP2", "CTPS1", "CTR9", "CYFIP1", "CYP51A1", "DDB1", "DDX17", "DDX3X", "DDX5", "DHCR24", "DHCR7", "DHX36", "DICER1", "DNA2", "DNAJC3", "DNM1L", "ELAC2", "ELP3", "ERAP1", "ERCC2", "ERGIC3", "EXO1", "EXOC2", "EXOC4", "EXOC7", "FGFR1OP", "FHL1", "FMR1", "FOXC1", "FOXRED1", "GCN1", "GINS1", "GINS2", "GINS4", "GMPS", "HIBCH", "HLA-C", "HMGB1", "IDH2", "IDH3A", "INA", "ITCH", "KDELR1", "KDELR3", "KDM2A", "KIFBP", "LARP7", "LBR", "LDAH", "LLGL1", "LRWD1", "LSM14B", "LZTS2", "MAU2", "MAVS", "MCM4", "MCM7", "MCTS1", "MIF", "MOV10", "MTA1", "MTOR", "MTR", "NAA15", "NAMPT", "NAP1L1", "NCAPD2", "NCAPH", "NCBP1", "NCK1", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFB3", "NDUFS1", "NDUFS2", "NEDD4L", "NES", "NONO", "NUDT21", "NUP37", "NUP43", "ORC3", "ORC5", "OTUB1", "OTUD7B", "PAFAH1B1", "PC", "PGAM5", "POLA2", "POLD2", "POLE", "POLR3A", "POLR3C", "POP1", "PPP6C", "PQBP1", "PREB", "PRKDC", "PRMT5", "PSMA1", "PSME4", "PTGES2", "PTK2", "QKI", "QRICH1", "RAB1A", "RBM4", "RFC1", "RFC3", "RFC5", "RINT1", "RIPK1", "RMDN3", "RPA1", "RPL10", "RRM1", "RRM2", "SAMHD1", "SDF4", "SEC24B", "SEC24C", "SERINC1", "SFPQ", "SH3PXD2B", "SHMT1", "SHMT2", "SIN3A", "SIRT1", "SLC30A7", "SLFN11", "SLIT2", "SMARCB1", "SMN1*", "SPATA5", "SRPK2", "STAT1", "SULT2A1", "SYNCRIP", "TACO1", "TARDBP", "TECR", "TP53", "TRAPPC11", "TRIP13", "TSG101", "TTC19", "TTC4", "TTLL12", "UBXN4", "UNC119B", "UPF2", "UQCR10", "UQCRC1", "UQCRQ", "USP7", "USP9X", "WDR4", "WDR61", "XPO5", "XRCC6", "YIF1A", "ZCCHC3"]} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/advanced/idx2term.json b/protein_atlas_disease_involvement/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/protein_atlas_disease_involvement/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/basic/idx2term.json b/protein_atlas_disease_involvement/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..7b8d63af643b195c577f898b28d7cfd1a24692ec --- /dev/null +++ b/protein_atlas_disease_involvement/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Dwarfism", "1": "Deafness", "2": "Limb-girdle muscular dystrophy", "3": "Neuropathy", "4": "Primary microcephaly", "5": "Proto-oncogene", "6": "Tumor suppressor", "7": "Charcot-Marie-Tooth disease"} \ No newline at end of file diff --git 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number of proteins per term", + "value": 20.846153846153847 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..06e5aacec81179527b192132ddcd6657a8cd128f --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..38a229b4cef07c9314f0b58b20fa1a9bec7ce990 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,33 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Dwarfism 0.4418452891925258 1.80275151499826 0.0714272478021529 0.9998284208643072 0.5969277137751351 46 Q96MF7,Q15813,Q14739,Q4G0J3,Q96ST3,O95831,Q7RTS9,Q99575,P62266,Q32P28,P18074,P19447,Q8TC12,Q9NUQ7,Q08209,P36776 16 +Deafness 0.4187389836238362 1.6979865649157844 0.0895102975795181 0.9999828138149772 0.6859879280573485 47 Q15067,O95831,Q13217,Q9NWM8,P26358,Q15046,P62266,P18074,Q12948,Q8NB90,P19447,Q16740,Q9Y4A5 13 +Limb-girdle muscular dystrophy 0.6509128169604173 1.5997617297961275 0.1096514517353204 0.9999987453389256 0.6859879280573485 8 Q5JTV8,Q9H9S5,Q9Y5P6,O14979,Q7Z392 5 +Palmoplantar keratoderma 0.6962031625605352 1.5663662744103568 0.1172628936850168 0.9999995405145288 0.6859879280573485 6 Q06136,P15924,Q9H4L7 3 +Ectodermal dysplasia 0.6377984622230077 1.303650645372437 0.1923527243593261 0.9999999999860382 0.8586118326964156 6 P61586,Q9H4L7 2 +Oncogene 0.8044162539329021 1.2867942833682993 0.1981660000009801 0.9999999999940036 0.8586118326964156 3 O43663 1 +Hereditary nonpolyposis colorectal cancer 0.793465245703455 1.2451909752559858 0.2130615591626701 0.9999999999993316 0.8586118326964156 3 P54277 1 +Neuropathy 0.3716151634423542 1.2362870070736494 0.2163518989811645 0.9999999999995904 0.8586118326964156 47 Q15067,O95831,Q13217,O15270,P26358,Q6DD88,Q15046,Q15526,Q15120,P39210 10 +Primary microcephaly 0.5929486253445332 1.2068356523025972 0.227495442851187 0.9999999999999234 0.8586118326964156 7 Q8NFH4,Q6UVJ0,Q15021,Q15003,P35606 5 +Hypotrichosis 0.5528151313820372 1.018723581579115 0.3083342140082044 1.0 1.0 7 Q8IWS0,Q12824,Q14574,Q9H1A4 4 +Congenital myasthenic syndrome 0.6169117393114333 0.9583054861472324 0.3379087382084456 1.0 1.0 4 Q4J6C6 1 +Lissencephaly 0.4968210926579083 0.9457247737627004 0.3442889832462565 1.0 1.0 10 P07942,P43034,Q9H9S5 3 +Ciliopathy 0.4899838536297565 0.9181045311758624 0.3585641428634334 1.0 1.0 9 O43924 1 +Proto-oncogene 0.3803924066388698 0.8400302493909925 0.4008914262772856 1.0 1.0 41 Q92733,Q9BQ52,Q06136,Q92804,P22681,P35637,Q01844,Q13951,P31751,Q01105 10 +Dystroglycanopathy 0.5662893615353956 0.7539962100359542 0.450851497492144 1.0 1.0 4 Q9Y5P6 1 +Zellweger syndrome 0.8293885601577861 0.6079848227080192 0.5431975400786562 1.0 1.0 2 P40855 1 +Peroxisome biogenesis disorder 0.8293885601577861 0.6079848227080192 0.5431975400786562 1.0 1.0 2 P40855 1 +Tumor suppressor 0.4044474638735438 0.5513484511989863 0.5813948306371217 1.0 1.0 28 Q12824,Q9NPI1,P21359,Q9ULC4,P49815 5 +Non-syndromic deafness 0.41154162783458 0.5053227814229951 0.6133321444886819 1.0 1.0 14 Q9Y4A5,O76024,Q15046,Q969T9 4 +Congenital muscular dystrophy 0.4729185809791345 0.488341770120674 0.6253077796294315 1.0 1.0 5 Q9Y5P6 1 +Leigh syndrome 0.3784833862511716 0.381577112057314 0.7027750638527059 1.0 1.0 10 Q9BSH4,Q7KZN9 2 +Diabetes mellitus 0.3780939376850797 0.3723565851446783 0.7096273736400476 1.0 1.0 11 P31751,P03886 2 +Charcot-Marie-Tooth disease 0.3767153709922257 0.3698888421824582 0.7114653154181694 1.0 1.0 25 O95831,Q15046,Q15526,Q15120,P39210 5 +Leber congenital amaurosis 0.4791559836300188 0.2198037185434402 0.8260240234770966 1.0 1.0 3 P20839 1 +Nephronophthisis 0.6190006574621919 0.1428120356087976 0.8864386314774844 1.0 1.0 2 Q9NQH7 1 +Progressive external ophthalmoplegia 0.5966469428007812 0.1160593907346633 0.9076054727573616 1.0 1.0 2 P51530 1 +Hermansky-Pudlak syndrome 0.4088960522099688 0.1045889655093459 0.916701970928674 1.0 1.0 3 O14617 1 +Albinism 0.4088960522099688 0.1045889655093459 0.916701970928674 1.0 1.0 3 O14617 1 +Amyotrophic lateral sclerosis 0.3063852855596916 0.0979990699031004 0.9219330319236771 1.0 1.0 15 Q9H9T3,P35637 2 +Cardiomyopathy 0.2991930456876129 0.0697586940091351 0.9443857244520302 1.0 1.0 21 P19022,P15924,P14923 3 +Ichthyosis 0.2912936829695535 0.0522859027026203 0.9583008859659004 1.0 1.0 7 P18074,P19447 2 +Li-Fraumeni syndrome 0.457922419460872 0.0348515283136889 0.9721981319113482 1.0 1.0 2 O96017 1 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a6cd1f5885bc36933dcb5c5cde6c223e41bd6a17 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atherosclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hemolytic uremic syndrome", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Phenylketonuria", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCD4", "ABHD12", "ABI1", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACVR1B", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT1", "AKT2", "ALCAM", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APEX1", "APOB", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARL2", "ARL3", "ARPC1B", "ARV1", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATL3", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6AP1", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7A", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BAG3", 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"LRP2", "LRPPRC", "LSS", "LTA4H", "LYN", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK3", "MARS", "MASTL", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MECR", "MED1", "MED12", "MED17", "MESD", "MFGE8", "MFSD8", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MOGS", "MORC2", "MPI", "MPV17", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSMO1", "MSN", "MSTO1", "MTA1", "MTMR2", "MTOR", "MTPAP", "MTR", "MUT", "MYH10", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB3", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEU1", "NF1", "NHLRC2", "NHP2", 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0000000000000000000000000000000000000000..63e4dacc458ec8f6ae46d0249f58adebf0ff6d29 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 96, + "title": "Average number of proteins per term", + "value": 37.833333333333336 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..65e4fa6fda73098115a473572f34a5f5fa650342 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..69d56811f120c311c98d9260b71ba6839443af3c --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,33 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Aminopeptidase 0.6563859017421687 1.7539076976926031 0.0794463243899403 0.9996462347463144 0.6780055438920357 10 P55786,Q9NZ08 2 +Methyltransferase 0.4270691157806567 1.663656053879297 0.096181183179214 0.9999392127688264 0.6780055438920357 46 Q9H7B4,O60725,Q9NRG4,P26358,Q96P11,Q8N1G2,Q6P2P2,Q9BV86,Q9H993 9 +Cytokine 0.7258970966689625 1.412166772064537 0.1579008617781634 0.9999999316293988 0.7501815410536656 4 P43490 1 +Metalloprotease 0.5342860820888264 1.3118193470914028 0.1895810954546939 0.9999999982776632 0.8165519321882341 27 Q9BYT8,Q9NZ08,Q7Z2K6,O75844,Q9UIQ6,P55786 6 +Monooxygenase 0.7908485278576596 1.23525696690317 0.2167348838761316 0.9999999999346504 0.8669395355045264 3 Q16850 1 +Cyclin 0.7423729097555287 1.052155119969422 0.292728386570487 0.9999999999999964 1.0 3 O95067 1 +Guanine-nucleotide releasing factor 0.4685028251282127 0.7920335955872198 0.4283410874312217 1.0 1.0 12 Q02818,Q92538,P80303,Q92888 4 +Exonuclease 0.465137680669663 0.768905038997387 0.4419496858243728 1.0 1.0 16 Q9GZR2,Q92499,Q9Y2L1,Q9UQ84,Q9H0D6,P27695 6 +Multifunctional enzyme 0.4345091835108765 0.7469226155654458 0.4551102736577277 1.0 1.0 29 P11498,O43252,P37268,O00763,Q13085,P50747 6 +Prenyltransferase 0.868507560815263 0.727050566921206 0.4671949794144994 1.0 1.0 2 P49356 1 +Calmodulin-binding 0.4149614712616645 0.6767074368113118 0.498591597063144 1.0 1.0 31 Q15417,Q01844,Q99439,O43815,Q5T4S7,O43795,P46020,Q13555 8 +Serine esterase 0.5403616422288796 0.6532731897923268 0.5135801732889047 1.0 1.0 4 Q9Y570,Q9Y305 2 +Serine/threonine-protein kinase 0.3052962476428115 0.563048776282715 0.573401670500826 1.0 1.0 54 P17612,P78362,P24941,P48729,Q86UE8,P11802,Q05655,P50750,Q00535,Q13418,Q96KB5,P31751,Q13546,P78527,Q13555,P31749,P42345 17 +Rotamase 0.4144199644657262 0.5263848620911674 0.5986208313579799 1.0 1.0 21 O95302,P62942,Q9Y680,Q9NWM8,Q8WUA2,P26885,Q13526 7 +Myosin 0.4037284433329473 0.5010266729936671 0.6163523511697246 1.0 1.0 9 O43795,P60660 2 +Motor protein 0.3952073921046724 0.4855056454354466 0.6273177090673561 1.0 1.0 27 P60660,Q86Y91,O43237,Q96Q89,Q9BW19,O43795,Q7Z406,Q02241,O60333 9 +Serine protease 0.4005100529991736 0.4175221489676926 0.6762965270508052 1.0 1.0 8 Q4J6C6,P36776,Q16740 3 +Developmental protein 0.3407314119374786 0.3938833455569128 0.6936671668173227 1.0 1.0 80 Q8NB78,Q13642,Q16352,Q9BX40,P43034,Q9H2U1,P31751,Q12948,Q8NB90,Q16527,Q05397,Q14997,Q7L576,Q96EK5,Q9BXJ9,P31749,P48681,Q13045,Q13555,Q96PU8 20 +GTPase activation 0.3638870001555051 0.3391091855341481 0.7345274789432543 1.0 1.0 28 P21359,Q92888,P49815,Q4KMP7 4 +Glycosyltransferase 0.339625328228734 0.3343406264447456 0.7381225370625077 1.0 1.0 35 Q13126 1 +Dioxygenase 0.3713159264294946 0.3236213452248824 0.7462247257732735 1.0 1.0 15 Q32P28,O00625 2 +Transducer 0.3767818787078719 0.2733999701952973 0.7845457756933429 1.0 1.0 7 P48960 1 +Ligase 0.2908705289470237 0.2526505191798935 0.8005382874735301 1.0 1.0 66 P11498,O43776,P05165,Q9NP81,Q15046,Q96RQ3,O00763,Q13085,P50747 9 +Protease 0.3303929470984451 0.2430183714769301 0.8079911656183894 1.0 1.0 86 O43847,Q9Y4P1,Q96KP4,Q7Z2K6,P28074,Q16740,Q9UIQ6,P55786,Q13867,P36776,P29144,P07384,Q96K76,Q9NZ08,Q9NUQ7,Q5TDH0,Q9BYT8,O75844,Q96RU2,Q92643,Q9UPU5,P81605,Q6GQQ9,Q96FW1,Q9H4A4,Q9HB40,Q4J6C6 27 +rRNA-binding 0.3415930618241067 0.2089239607621837 0.8345075989127595 1.0 1.0 15 P62917,P61927 2 +Chromatin regulator 0.3206836839508666 0.1662600628228706 0.8679522938123734 1.0 1.0 88 Q9H7B4,Q8NB78,Q86UE8,Q9NRG4,Q12824,Q12873,O14497,Q9BXF3,Q9H8M2,Q99543,Q9H4L7,Q9Y4A5 12 +Translocase 0.323986519720271 0.1412070487042299 0.8877063778122511 1.0 1.0 20 P28331,P03886,O75306 3 +Protein phosphatase 0.3139252443409029 0.1138127748955577 0.9093862114974368 1.0 1.0 17 O15355,P51452,Q9NRX4,O00743,Q08209 5 +tRNA-binding 0.3111571980526962 0.1082805132634125 0.9137731798851284 1.0 1.0 16 Q9HAV4,O43592,P18077,Q9H9T3,Q7Z7L1,Q9UBP6 6 +Thiol protease 0.2928886044930009 0.0905673051227864 0.9278364118645812 1.0 1.0 32 Q96RU2,Q9Y4P1,P07384,Q9UPU5,Q92643,Q96K76,Q6GQQ9,Q96FW1,Q13867 9 +Allosteric enzyme 0.2873673694300791 0.0428459555698809 0.9658243303562212 1.0 1.0 19 Q13085,O00763 2 +Initiation factor 0.2613013210495019 0.0319527059828433 0.9745097667777972 1.0 1.0 36 Q13144,P60228,Q7L2H7,Q15056,P55884,Q7Z478,Q9BY44,Q9ULC4,Q9Y262,P49770,Q9NR50,P55010,Q9UI10,O15371,Q14152,Q9UBQ5,Q14232,O75822,O15372 19 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f0a3344893662910948a026b9ec822ca1f6b1551 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "G-protein coupled receptor", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APLP2", "APOB", "APOBEC3C", "APP", "APRT", "AQR", "ARFGAP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATG3", "ATG4B", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BANF1", "BAP18", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPHL", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRD9", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "CAD", "CALCOCO1", "CALD1", "CALR", "CAMK2G", "CANT1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPN5", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBL", "CBR1", "CBX3", "CBX4", "CBX8", "CCAR1", "CCAR2", "CCDC25", "CCDC47", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CD46", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CEP290", "CEP55", "CERK", "CERS1", "CERS2", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHKA", "CHMP1A", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPE", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSB", "CTSC", "CUL5", "CXADR", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCD", "DCP2", "DCPS", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DRG1", "DRG2", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EGFR", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERMP1", "ERO1A", "ESD", "ESPL1", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "F11R", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "IQGAP1", "IQGAP2", "IRF2BP1", "IRS4", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITPA", "ITPK1", "IVD", "KARS", "KAT7", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC1", "KMT2A", "KRR1", "KYAT3", "L3HYPDH", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD3", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC8E", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "M6PR", "MACF1", "MAGED2", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1S", "MAP2K1", "MAP2K4", "MAP4K5", "MAPK1", "MAPK3", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFN1", "MGAT1", "MGEA5", "MGST2", "MGST3", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "ND1", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NEU1", "NF1", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NUSAP1", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "OTUB1", "OTUD4", "OTUD7B", "P3H1", "P3H3", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM7", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHF5A", "PHF6", "PHGDH", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PIGA", "PIGK", "PIK3C2A", "PIN1", "PIN4", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS3", "PLXNB2", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTB", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALB", "RALGAPB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "RETSAT", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIOX2", "RIPK1", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP130", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMPDL3A", "SMS", "SMYD2", "SMYD3", "SMYD5", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAMBP", "STAT1", "STAT3", "STAU1", "STK26", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SULT2A1", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TCEA1", "TCERG1", "TCF25", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TLK2", "TMCO1", "TMEM109", "TMEM206", "TMOD1", "TMOD3", "TMTC3", "TMX3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSN", "TSNAX", "TST", "TSTA3", "TTK", "TTYH3", "TUFM", "TULP3", "TWF1", "TXNDC12", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBR4", "UBR5", "UBTF", "UCHL5", "UCK2", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UROD", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP3", "UTRN", "UXS1", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VLDLR", "VPS4A", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "ZADH2", "ZC3H14", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZDHHC13", "ZFR", "ZMPSTE24", "ZNF281", "ZNF318", "ZNF326", "ZNF346", "ZNF512B", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["ACACA", "ACACB", "ACOT9", "ADGRE5", "AKT1", "AKT2", "APEX1", "ARHGEF1", "ARID1A", "ARMT1", "ATG4B", "BLMH", "BRD9", "CAMK2G", "CAPN1", "CCNB2", "CDK2", "CDK4", "CDK5", "CDK9", "CECR2", "CHD3", "CLPP", "CMTR1", "CNDP2", "CNN2", "CNN3", "CSNK1A1", "CSRP2", "CYFIP1", "CYP51A1", "DCD", "DDI2", "DDX1", "DHX29", "DHX36", "DIS3", "DNAJC2", "DNMT1", "DUSP3", "DYNC1LI2", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3H", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4H", "EIF5", "ELP3", "ERAP1", "ERMP1", "EWSR1", "EXO1", "FDFT1", "FHL1", "FKBP14", "FKBP1A", "FKBP2", "FKBP7", "FKBP9", "FLII", "FNTB", "FOXC1", "GBF1", "HLCS", "ICMT", "ILK", "INA", "KARS", "KDM1B", "KIF18B", "KIF1B", "KIF20B", "KIF23", "KIFBP", "KIFC1", "LNPEP", "LONP1", "LSM14B", "MCCC1", "MCTS1", "METTL1", "MTAP", "MTOR", "MYH14", "MYL6", "MYO1B", "NAA15", "NAMPT", "NARS", "ND1", "NDUFS1", "NDUFS2", "NES", "NF1", "NLN", "NPEPPS", "NRDC", "NSUN5", "NTMT1", "NUCB1", "NUCB2", "OTUB1", "OTUD7B", "P3H1", "PAFAH1B1", "PAPSS1", "PBK", "PC", "PCCA", "PHKA1", "PHPT1", "PIGK", "PIN1", "PIR", "PPIL4", "PPM1G", "PPME1", "PPP3CA", "PPP6C", "PREPL", "PRKACA", "PRKCD", "PRKDC", "PRMT9", "PSMB5", "PSME4", "PTK2", "QKI", "REXO4", "RIPK1", "RNPEP", "RPL35A", "RPL37", "RPL8", "SARS2", "SCPEP1", "SLFN11", "SMARCAD1", "SMARCB1", "SMYD2", "SMYD3", "SPATA5", "SRPK2", "STRN", "TBC1D10B", "TLK2", "TPP2", "TRRAP", "TSC2", "UBR4", "UFSP2", "USP24", "USP28", "USP47", "XPO5", "XPOT", "XRN2", "ZMPSTE24"]} \ No newline at end of file diff --git a/protein_atlas_protein_class/advanced/idx2term.json b/protein_atlas_protein_class/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f46efabc2bf6a6436134fbd4134d682ba19052fc --- /dev/null +++ b/protein_atlas_protein_class/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Predicted intracellular proteins"} \ No newline at end of file diff --git a/protein_atlas_protein_class/advanced/plot_0.png b/protein_atlas_protein_class/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c7a5c7c5dcbe23d1d0f912d742f64a501061e9ef --- /dev/null +++ b/protein_atlas_protein_class/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ddf8b62ffb6664c41d1fd143ccc3b9e514ecbb67c9ec3cb3f1fa5c8e06726bbe +size 234266 diff --git a/protein_atlas_protein_class/basic/idx2term.json b/protein_atlas_protein_class/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..917b9caede7951220d6818754869f6117b3221c4 --- /dev/null +++ b/protein_atlas_protein_class/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Predicted intracellular proteins", "1": "RAS pathway related proteins", "2": "Enzymes"} \ No newline at end of file diff --git a/protein_atlas_protein_class/basic/plot_0.png 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0000000000000000000000000000000000000000..e018c558b44e9fb3b735240b6f6da3b301c707ae --- /dev/null +++ b/protein_atlas_protein_class/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f3cba86e1989c21ecfc1c63c9347caf6e07b2e8f969f863caf98e7596fb78ecd +size 133236 diff --git a/protein_atlas_protein_class/consensus.joblib b/protein_atlas_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..82b26e9802ad7fa6a4027bbbd4193ea630d2c4c7 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0253000db3b59559205d59c761e501222a404061a797da8ee03d0865efaff26f +size 78441 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..418e58861dcc9f21183b448cca2b23f31b8ba253 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted intracellular proteins 656 2804 inf 0.0 1052.9126213592233 2930.233009708738 -5.248196350890207 0.108353777008802 367.4824441165934 294.4528727150831 7.24167812525605 0.3049463326237019 0.6488222319110596 0.232057932208307 0.631641033588237 0.878950284205031 0.356160017686023 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2866b7e2dccfb689a3cb4f65cb47b9c165fefeb3 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 21, + "title": "Average number of proteins per term", + "value": 472.0 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b2692139836f51f385163cb2816be35d7da5be7f --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..02e7404e31254ce0a7a97494d44b15111ebbae4d --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted intracellular proteins 0.1816689144748484 inf 0.0 2.1000000000000002e-17 2.1000000000000002e-17 2804 Q9H7B4,O75153,Q15392,Q8NB78,P07099,O95831,Q9NRG4,A6NIH7,Q13126,O43772,Q7RTS9,Q9UHG3,Q9UQB8,Q9H6V9,O95456,P49721,Q06520,O15217,Q5ZPR3,P28074,Q9H773,Q9UQ84,Q9BV86,P35790,P39210,Q16850,P55786,Q969T7,P43490,Q96D46,P29083,Q9NQZ5,Q9Y282,Q14739,P80303,O60888,P28070,Q06136,Q7Z6M1,P78318,Q6DD88,Q9NVJ2,P50750,Q9NZ08,P21266,Q32P28,Q96CP7,P31751,Q12948,Q8NB90,Q16527,Q9NPI1,P18887,P21359,P50747,Q9NVC6,P84098,O43924,Q05397,Q9HD26,Q9HAU5,Q14914,Q86UE8,O43852,P55010,Q92804,Q96PU5,Q15386,Q96RQ3,Q9NRX4,Q3YEC7,Q9Y5P6,O94822,Q8NEW0,Q93050,Q9P016,O00763,O14678,Q9BU89,Q9Y4P8,P26885,Q99805,Q9BRR6,Q9BXJ9,Q969E2,O95376,O95684,P11498,Q96QE3,Q9UNK9,P05165,Q14331,Q92643,Q9BWS9,Q99575,P26368,O60830,O43815,A0AVF1,P30837,Q86UY6,Q8NCF5,Q9HA64,Q9UBD5,Q9UM22,Q9Y6V7,Q9Y6X3,Q4G0N4,P49815,Q13085,P49356,Q15555,Q4J6C6,P48960,Q7Z4H3,Q9UHY1,P98155,P30519,O95429,P50452,P48735,Q16625,Q9UJW0,P34897,P50213,Q9H7E9,Q9NUJ1,Q92674,Q13951,Q15293,P20618,Q14257,P13804,Q96M27,P50748,Q96ST2,Q9NU22,Q8IY18,Q7LGA3,P98179,Q9NPH0,O95067,P17612,Q96A65,Q99547,Q9NRY5,Q9UGR2,Q16836,Q14181,Q13442,P07942,P15924,P28331,P35637,P52597,P57081,Q93074,Q9UBF8,Q92572,Q9H9T3,Q9BZZ5,P06132,O95400,P46783,Q9BUK6,Q9ULC4,Q92888,Q9NRN7,Q9H9H4,Q9H4L7,Q4KMP7,Q5TDH0,Q92733,P61978,Q12824,Q13217,Q5JTV8,Q86WA6,Q9BYT8,Q12873,Q99733,Q8N1G2,Q658Y4,O95881,P55795,P55209,P54277,O75874,O14979,P57678,Q9H8M2,Q68EM7,P10412,P51991,P14923,Q99543,Q9Y4A5,Q9NZ32,Q9H910,Q9H0H0,Q9GZR2,Q8WUX2,Q96RU2,P78330,P31943,O60502,O60499,O43813,Q99627,Q96EY5,Q5R3I4,Q6GQQ9,Q7Z4V5,Q96FW1,Q9Y312,Q9UPN9,Q9NVE7,Q9NRF9,Q96SY0,Q9BTT6,Q14011,Q13555,P42345,P34896,O60784,O43847,O14802,Q8N0X7,Q9Y680,Q9Y5Y2,Q9Y4P1,Q9Y248,Q9P2N5,Q8WZA0,P22681,Q6DKK2,Q01844,P61927,P31942,O14497,O60506,O43795,Q96CW5,Q9BSH4,Q9BX40,Q9BXF3,Q16740,Q16637,Q96TC7,Q8N511,Q13867,Q9H857,Q9H993,Q9NQ48,Q9UPN7,Q15417,Q15813,P56378,Q15067,Q07864,P78362,O43252,P48729,P33240,P26358,O95487,Q15046,Q8NBT2,Q9BRK5,Q99720,Q96NB2,Q96DE5,Q9BUI4,Q6NUQ1,P61026,O43808,O00625,Q14534,P78527,Q9Y6J9,Q92538,Q13526,Q01105,P63208,P40855,P25786,P23786,Q9BQ52,Q86WR0,Q96DY7,Q8IY67,Q86Y91,Q99829,P37268,P11802,O75448,O75306,O15511,O14654,P18074,Q7L576,Q6FI81,Q6P2P2,Q6W2J9,Q9Y3Z3,Q8WUA2,Q96EK5,Q14168,Q2TAL8,Q8NFH3,Q02241,P31749,Q00169,P11182,O14949,P48681,P62753,P62917,Q8IV63,Q9NXV2,Q9NWM8,Q9NP81,Q9BYD3,Q96P11,Q92783,Q92620,P62266,Q6PD62,Q13045,P53992,P19022,P12956,O60828,O14646,Q86UE4,Q15120,Q15276,Q6NUQ4,P82663,Q8N335,Q9HB40,Q9HBM1,Q15006,O43156,P62910,P04350,P61313,O43663,O43776,O43324,P17812,P42858,P52756,Q15036,Q96Q89,Q96KP4,Q86X55,Q86U90,Q5T4S7,P53611,P46776,P22626,P22059,P19447,O95639,O95302,O95071,O15397,Q8WVC6,Q9Y487,Q9Y2R9,Q9HCU5,Q9HCE1,Q9H4A5,Q9BWD1,Q96JJ7,P00390,Q7Z5K2,P60660,P55884,P41208,P07384,A1X283,Q07021,Q9H2U1,Q96K76,Q9BW19,Q9BWF3,Q9GZS3,Q9UPT5,Q9H553,Q9HD20,Q9NVX2,Q9Y512,Q92879,Q969T9,Q8TC12,P52788,Q8IUF8,P35080,P36404,P48163,O60333,P68402,Q14997,Q53GG5,Q6PGP7,O15091,Q9UDY2,Q9P258,Q9NVZ3,Q9NVU7,Q9HAS0,Q9H9S5,Q9H2D1,Q99439,Q96CW1,Q86Y39,Q7Z739,Q15334,P22392,Q14691,O00571,O43913,P14174,O75787,P35606,P60900,P62820,P83881,Q07666,Q96MF7,Q8IWS0,Q8TAE8,Q8WTV0,Q96F07,Q96ST3,Q9BRT9,Q9NRF8,Q9NXF1,Q9UPU5,Q86U42,O43865,Q05655,O95628,O75600,O75746,O94776,O00743,O95801,P08708,P46020,P52701,P62942,Q7L5D6,Q9UNS2,Q9NZW5,Q9H4A4,Q9H0D6,Q9GZR7,Q99816,Q96PU8,Q92990,Q7Z417,Q8NFH4,Q15043,P33993,O60884,P24941,P30154,Q14241,Q14562,O60678,Q5VYK3,Q13137,Q13642,Q15154,Q16352,Q1ED39,Q5JPH6,Q92621,Q7L2H7,Q8IYS1,Q8N4Q0,Q05519,Q96J02,Q99873,Q9H0E9,Q08209,P36776,P82650,P31689,P78316,O14737,O43765,P29144,P30153,P08621,P36578,P37287,P40937,P43034,P51452,P61586,Q9BZL1,Q8IUD2,Q92547,Q96F86,Q96KB5,Q96MU7,Q9BQ70,Q9BRK4,Q9UPY3,Q5VTL8,Q9H1A4,Q9NNW5,Q9NUQ7,Q9NUQ9,Q9P2J5,Q9Y237,Q7Z392,P49770,Q53EL6,P27635,Q4G0J3,O14744,O75935,O95070,P20248,P25054,O43237,P55196,P62241,P62701,Q00535,Q13084,Q13418,Q15648,P60953,Q99436,Q6ZSJ8,Q7L5N1,Q8NE86,Q8WTS6,Q96CU9,Q9NVN8,Q99615,Q9H2J4,Q9NPE3,Q9UBB6,Q9UBQ5,Q15233,Q5SW79,Q9ULX6,Q13395,P28370,Q12834,O43809,O94813,P00374,P18621,P21283,P06756,P40763,P42224,P42765,P52888,P53004,P53621,Q13546,Q5VTB9,Q6NUM9,Q99496,Q9BT78,Q9H4M9,Q9Y4B6,Q9NPJ6,Q9NPQ8,Q9UBX3,Q9UJC5,Q9Y3U8,Q10471,P83731,P63151,P14866,P61457,O00231,O14579,O15355,O43390,O60231,O43172,P16333,P17844,P21399,P28066,P51648,P60228,Q9H7B2,Q92616,Q92890,Q92945,Q96AE4,Q9BZJ0,Q9GZN8,Q9Y5Q9,Q9HB07,Q9NUD5,Q9NW15,Q9UHB9,Q9Y520,Q8NI27,P27695,Q8IX18,P67870,Q7Z460,O00410,O14530,O43592,P08237,P18077,O96028,Q06787,Q12907,Q14145,Q16134,Q5M775,Q70UQ0,Q92564,Q13451,Q14157,Q15019,Q15286,Q6NXE6,Q8N8S7,Q9UI26,Q9BUJ2,Q9GZZ1,Q9H089,Q9NVR2,Q9UBP6,Q9UFC0,Q04760,Q9Y2K7,Q10472,Q15369,Q02543,P10321,Q00610,A5YKK6,O15144,O60508,O75533,O76024,O76094,O43396 656 +Citric acid cycle related proteins 0.3263833417040111 0.1592915495598841 0.873439178229177 1.0 1.0 25 P11498,P50213,P48735 3 +RAS pathway related proteins 0.282161779446172 0.0477470509901354 0.961917835572287 1.0 1.0 30 P17612,P55196,P61586,P31751,P21359,P31749 6 +Enzymes 0.2652007066961768 0.0406831281532679 0.9675485122425662 1.0 1.0 884 Q9H7B4,Q15392,Q8NB78,P07099,Q9NRG4,Q13126,Q9UHG3,P49721,Q06520,O15217,P28074,Q9H773,Q9BV86,P35790,Q16850,P55786,Q969T7,P43490,Q14739,P28070,Q06136,P50750,Q9NZ08,P21266,Q32P28,P31751,Q8NB90,P50747,P03886,Q05397,Q14914,Q86UE8,Q96PU5,Q15386,Q96RQ3,Q9NRX4,Q9Y5P6,O94822,O00763,Q9BU89,P26885,Q9BRR6,Q9UBM7,O95376,P11498,P05165,Q96G23,Q92643,Q99575,P30837,Q86UY6,Q9HA64,Q9Y6V7,Q4G0N4,Q13085,P49356,Q4J6C6,Q7Z4H3,Q9UHY1,P30519,P48735,P34897,P50213,Q7Z2K6,Q9NUJ1,P20618,Q9UIQ6,Q9NPH0,P17612,Q16836,P28331,Q9UBF8,P06132,Q9NRN7,Q9H4L7,O60725,Q9BYT8,Q12873,Q8N1G2,O95881,O75874,O75844,Q8WUX2,Q96RU2,P78330,O60502,O43813,Q6GQQ9,Q96FW1,Q9UPN9,Q13555,P42345,P34896,O43847,O14802,Q9Y680,Q9Y4P1,P22681,Q9NZ01,Q16740,Q13867,Q15067,Q07864,P78362,O43252,P48729,P26358,Q15046,P61026,O00625,Q14534,P78527,Q13526,P33908,P25786,P23786,Q9BQ52,P37268,P11802,O75306,P18074,Q6P2P2,Q8WUA2,P31749,P11182,Q8IV63,Q9NWM8,Q9NP81,Q92620,O14646,Q15120,Q8N335,Q9HB40,Q9Y251,O43776,P17812,Q96KP4,Q86X55,Q5T4S7,P53611,P19447,O95302,O95071,Q9HCE1,Q9BWD1,Q96JJ7,P00390,P07384,O15270,Q9H2U1,Q96K76 151 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..640c959eb2641b94048be333a501c5a04c632c3a --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "G-protein coupled receptors", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG12", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8B", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ARV1", "ASAH1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCCIP", "BCL10", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRI3BP", "BRIX1", "BROX", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C14orf2", "C17orf75", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALM3", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC25", "CCDC47", "CCDC6", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC23", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPI", "CENPM", "CENPV", "CEP170", "CEP290", "CEP44", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP3", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT4", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC1", "DSC2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM136A", "FAM162A", "FAM177A1", "FAM208A", "FAM213A", "FAM234B", "FAM3C", "FAM49B", "FAM50A", "FAM83D", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FRG1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLM2", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HPSE", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS2", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIRREL1", "KLC1", "KLHDC4", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMB1", "LAMC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LDLR", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRRC8E", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZIC", "LZTFL1", "LZTS2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAP7D1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17", "MPV17L2", "MRC2", "MRE11", "MRFAP1", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHLRC2", "NHP2", "NID1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTHL1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE4DIP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGA", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PMVK", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PROCR", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB24", "RAB2A", "RAB35", "RAB39A", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALB", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SASS6", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A4", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC7A1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORL1", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPOUT1", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKT", "TLCD1", "TLK2", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM14C", "TMEM160", "TMEM165", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM206", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM30A", "TMEM33", "TMEM43", "TMEM59", "TMEM87A", "TMEM9", "TMEM97", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX3", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSR2", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTI1", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGCG", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR73", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZDHHC13", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF346", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAR2", "AASDHPPT", "ABCD4", "ABHD10", "ACAA2", "ACACA", "ACACB", "ACAT2", "ACO1", "ACOX1", "ACP6", "ACTR10", "ADGRE5", "ADPGK", "AFDN", "AHCYL1", "AIFM1", "AKAP8L", "AKT1", "AKT2", "ALDH1B1", "ALDH3A2", "ALG2", "ANAPC1", "ANAPC16", "ANGEL1", "ANO10", "AP2M1", "AP3S1", "APC", "APEX1", "API5", "ARHGAP17", "ARHGEF1", "ARID1A", "ARIH2", "ARL2", "ARL8B", "ARMC6", "ARMT1", "ARPC2", "ARPC5", "ATAD5", "ATG4B", "ATL3", "ATP13A1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V1C1", "BAG4", "BAIAP2", "BCOR", "BLMH", "BLVRA", "BPHL", "BRD7", "BRD8", "BRD9", "C14orf2", "C17orf75", "C1QBP", "C1orf122", "C20orf27", "C8orf33", "CALCOCO2", "CALU", "CAMK2G", "CAPN1", "CARM1", "CBFB", "CBL", "CCDC25", "CCNA2", "CCNB2", "CD276", "CD2BP2", "CDC20", "CDC40", "CDC42", "CDH2", "CDK2", "CDK4", "CDK5", "CDK9", "CECR2", "CELF1", "CENPI", "CEP170", "CERS2", "CETN2", "CHAC2", "CHD1", "CHD3", "CHID1", "CHKA", "CIAPIN1", "CIRBP", "CLASP1", "CLPP", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT4", "COPA", "COPB2", "COPE", "COPS3", "COPS4", "COPS6", "COPS8", "CPNE1", "CPSF4", "CPT2", "CRNKL1", "CSNK1A1", "CSNK2B", "CSRP2", "CSTF2", "CTPS1", "CTPS2", "CTR9", "CUTA", "CYFIP1", "CYFIP2", "CYP51A1", "DBT", "DCAF1", "DCAKD", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DDI2", "DDX24", "DDX3X", "DDX49", "DDX5", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX36", "DHX38", "DHX40", "DHX8", "DICER1", "DNAJA1", "DNAJA2", "DNAJC2", "DNAJC3", "DNAJC7", "DNMT1", "DOHH", "DSP", "DUSP3", "DYM", "DYNC1LI2", "EARS2", "EDC3", "EEF1E1", "EHD1", "EIF2B2", "EIF3B", "EIF3E", "EIF3K", "EIF3M", "EIF5", "ELAC2", "ELOA", "ELOC", "ELP3", "EMC2", "ENAH", "EPDR1", "EPHX1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERMP1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC4", "EXOC7", "FAM114A2", "FAM49B", "FAM91A1", "FDFT1", "FGFR1OP", "FHL1", "FKBP14", "FKBP1A", "FKBP2", "FKBP5", "FKBP7", "FKBP9", "FKRP", "FLII", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXRED1", "FRG1", "FUBP1", "FUS", "GADD45GIP1", "GALNT1", "GALNT2", "GBF1", "GCAT", "GCN1", "GEMIN4", "GET4", "GINS1", "GINS2", "GINS4", "GLMN", "GLO1", "GMPPB", "GNL3L", "GOLPH3L", "GOPC", "GPD1L", "GSR", "GSTA4", "GSTM3", "GTF2E1", "GTF3C3", "HADH", "HDDC2", "HDGFL2", "HIST1H1E", "HLA-C", "HLCS", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPR", "HNRNPUL1", "HPSE", "HS2ST1", "HTT", "ICMT", "IDH1", "IDH2", "IDH3A", "IGBP1", "IKBIP", "ILK", "INA", "INTS10", "INTS14", "INTS2", "IPO11", "IPO5", "IPO8", "IRS4", "ITCH", "ITGAV", "IWS1", "JPT2", "JUP", "KARS", "KCTD5", "KDM1B", "KDM2A", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF18B", "KIF1B", "KIF20B", "KIF23", "KIFBP", "KIFC1", "KNOP1", "KNTC1", "LAMB1", "LANCL1", "LARP7", "LARS", "LBR", "LDAH", "LLGL1", "LMAN2", "LNPEP", "LONP1", "LRRC1", "LRWD1", "LSG1", "LSM14B", "LTN1", "LZIC", "LZTFL1", "LZTS2", "MAN1A1", "MAPRE2", "MAU2", "MCCC1", "MCM7", "MCTS1", "MCU", "MDN1", "ME1", "MED1", "MED12", "MED17", "MED24", "MED4", "METTL1", "MGEA5", "MIF", "MOV10", "MPHOSPH6", "MPP2", "MPP6", "MPV17", "MRPL28", "MRPL4", "MRPS22", "MRPS25", "MRPS7", "MSH6", "MSTO1", "MTA2", "MTAP", "MTBP", "MTDH", "MTOR", "MVB12A", "MYG1", "MYL6", "MYO1B", "NAA15", "NAA40", "NAA50", "NADK2", "NAMPT", "NAP1L1", "NAP1L4", "NARS", "NCDN", "NCK1", "ND1", "NDUFA11", "NDUFS1", "NDUFS2", "NECAP2", "NEDD4L", "NES", "NF1", "NFATC2IP", "NLE1", "NLN", "NMD3", "NME2", "NONO", "NOP10", "NOP14", "NPEPPS", "NRBP1", "NRDC", "NSD2", "NSMCE2", "NSUN5", "NT5C3B", "NT5DC2", "NTMT1", "NUBP2", "NUCB2", "NUDT21", "NUFIP2", "NUP205", "NUP37", "NUP43", "OCLN", "ORC3", "ORC5", "OSBP", "OTUB1", "OTUD7B", "P3H1", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PANK4", "PAPSS1", "PBK", "PC", "PCBD1", "PCCA", "PCM1", "PCYOX1", "PDAP1", "PDCD4", "PDCD5", "PDCL3", "PDE6D", "PDK3", "PDLIM3", "PEX19", "PFKM", "PFN2", "PHF6", "PHKA1", "PHPT1", "PI4KB", "PIGA", "PIGK", "PIN1", "PIN4", "PIR", "PITPNA", "PM20D2", "PMS1", "POLA2", "POLE", "POLE3", "POLR3A", "POLR3C", "POP1", "PPIL4", "PPM1G", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP3CA", "PPP6C", "PPP6R1", "PQBP1", "PRC1", "PRCC", "PREB", "PREPL", "PRKACA", "PRKCD", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF38B", "PRPF4", "PRRC1", "PRRC2C", "PSMA1", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB7", "PSMD11", "PSME4", "PSMG1", "PSPH", "PTGR1", "PTK2", "QKI", "QRICH1", "RAB10", "RAB1A", "RAB35", "RABEP1", "RABEPK", "RABGGTB", "RABL6", "RAVER1", "RBM27", "RBM3", "RBM4", "RBM5", "RCC2", "RCN1", "RCN2", "RDH11", "RETSAT", "REXO4", "RFC5", "RHOA", "RIC8A", "RINT1", "RIOX2", "RIPK1", "RMDN3", "RNF2", "RNF220", "RNPEP", "RPF2", "RPL10", "RPL15", "RPL17", "RPL18A", "RPL19", "RPL24", "RPL27A", "RPL32", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL4", "RPL8", "RPS10", "RPS17", "RPS23", "RPS4X", "RPS6", "RPS8", "SAMHD1", "SAMM50", "SARS2", "SCAMP4", "SCARB1", "SCPEP1", "SDAD1", "SDF4", "SEC24B", "SEC24C", "SEPT2", "SERPINB8", "SET", "SETD7", "SF3B1", "SFXN2", "SGTA", "SH3BGRL2", "SH3PXD2B", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKP1", "SLC25A10", "SLC25A12", "SLC25A17", "SLC25A20", "SLC25A32", "SLC30A7", "SLC39A14", "SLIT2", "SMARCA1", "SMARCAD1", "SMARCB1", "SMC5", "SMN1*", "SMS", "SMYD2", "SMYD3", "SNRNP70", "SNX17", "SPART", "SPATA5", "SPC24", "SPC25", "SPECC1", "SPTLC2", "SQLE", "SRP68", "SRP72", "SRPK2", "SRSF11", "STAM", "STARD7", "STAT1", "STAT3", "STRN", "STX10", 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0000000000000000000000000000000000000000..fed86c141bd9c1e5043905b0bb2b4d03979236af --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3044, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 143.72727272727272 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f110fd8f9338020c6c8cdbf67a81672bca3324f3 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C312/C312_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..77e20ad2ea60a572221d3995d43b5cf239b71408 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,13 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Microtubules 0.3546339576907265 1.073722811054404 0.2829469344345183 0.9999828922539014 1.0 52 P04350,O43663,O75629,P34897,O43813,O60830,Q658Y4,Q6GQQ9,P55209,Q6P2P2,Q02818,P31749 12 +Cytoplasmic bodies 0.5068475705052309 0.9934094309098256 0.3205104674860419 0.9999971024466704 1.0 17 Q9HAU5,P50750 2 +Microtubule ends 0.635666941206356 0.6656308453944016 0.5056470856030393 0.9999999999199752 1.0 3 Q86Y91 1 +Lipid droplets 0.3837963795130426 0.3966485493868827 0.6916266458649467 1.0 1.0 11 Q969E2 1 +Cytosol 0.2140970775576027 0.2990399125378122 0.7649095923047176 1.0 1.0 1075 Q9H7B4,Q92990,Q7Z417,O60884,Q9NRG4,P24941,Q13126,O43772,P30154,P61803,Q9UQB8,Q14241,O95456,Q13137,Q06520,Q13642,Q15154,Q16352,Q9H773,Q1ED39,Q9BV86,Q7L2H7,P55786,Q08209,P31689,O14737,P29144,P30153,P36578,P78318,P51452,P61586,Q9NZ08,P21266,Q8IUD2,Q96KB5,P31751,Q12948,Q8NB90,Q9BRK4,Q9NPI1,Q9UPY3,Q9H490,Q9NNW5,P50747,Q9NVC6,Q9NUQ7,P84098,Q9NUQ9,Q9P2J5,Q05397,Q7Z392,Q9H061,Q9HAU5,P27635,Q4G0J3,O14744,O75935,P55010,P20248,O43237,P62241,Q9NRX4,Q3YEC7,O94822,Q99436,Q93050,Q9P016,Q9BU89,Q9Y4P8,Q9NVN8,Q99615,Q9H2J4,Q9BXJ9,Q9UBB6,Q9UBQ5,Q5SW79,Q96QE3,Q12834,P18621,P21283,P06756,P40763,P42224,O43815,P52888,P30837,Q86UY6,P53004,P53621,P49815,Q13085,P48960,Q9UHY1,P30519,P50452,Q92674,Q13951,P50748,Q9NU22,O95067,P17612,Q96A65,Q9UGR2,Q14181,Q13442,P57081,Q9H9T3,P06132,O95400,P46783,Q9BUK6,Q9ULC4,Q92888,Q5TDH0,O75874,P57678,Q68EM7,Q99543,Q9NRX5,Q9H910,Q8WUX2,P78330,O60502,Q99627,Q5R3I4,Q96FW1,Q9Y312,Q9NVE7,Q9BTT6,Q13555,P42345,P34896,O60784,Q8N0X7,Q9Y5Y2,Q9Y4P1,Q8WZA0,P22681,O60506,Q16637,Q13867,Q9H993,Q9NQ48,Q9UPN7,Q15417,P78362,P48729,Q15046,Q96DE5,O00625,Q14534,Q13526,P63208,Q86WR0,Q86Y91,P11802,O15511,P18074,Q6P2P2,Q8WUA2,Q14168,Q8NFH3,Q00169,P24390,P62753,P62917,Q9NWM8,P62266,Q13045,Q6NUQ4,Q9HBM1,P62910,O43776,O43324,P17812,P42858,Q15036,Q96Q89,Q96KP4,Q5T4S7,P46776,P22059,O95071,Q9HCE1,Q9H4A5,Q9BWD1,P00390,P55884,P41208,P07384,Q9H2U1,Q9BWF3,Q9GZS3,Q9UPT5,Q969T9,Q7L0J3,P52788,P36404,P48163,P68402,Q53GG5,Q6PGP7,Q9HAS0,Q9H9S5,Q99439,P22392,O00571,O43913,P14174,P62820,P83881,Q96F07,Q9NRF8,Q9UPU5,O43865,Q05655,O15260,O75746,P08708,P46020,Q7L5D6,Q9UNS2,Q9GZR7,Q99816 225 +Cell Junctions 0.2595313934773714 0.253651500283479 0.7997648059421651 1.0 1.0 47 Q16625,P15924,O15511,Q14574,P14923,Q13555,P43490 7 +Intermediate filaments 0.3052556684022226 0.115630764157735 0.9079451801674774 1.0 1.0 30 P48681,O60884,Q9BWS9,Q96K76,O95801,Q9NU22 6 +Cytokinetic bridge 0.3039066788099923 0.1046031514252236 0.9166907139516938 1.0 1.0 29 P17612,P04350,P98155,O43663,Q96QE3,Q6GQQ9,Q96TC7 7 +Focal adhesion sites 0.2814575245946638 0.0417557214716415 0.966693433350446 1.0 1.0 29 Q05397,Q9NZ32,O60888,Q13418,Q9Y487,P36404,P49770 7 +Centriolar satellite 0.2728100483240568 0.025573327171286 0.979597660944074 1.0 1.0 30 O60784,Q96QE3,P98155,Q12873,Q13045,Q86UY6 6 +Peroxisomes 0.25962651179849 0.0006510773497128 0.9994805154714774 1.0 1.0 14 Q15067,O43808,P40855 3 +Centrosome 0.2384005438629463 1.4431194693542922e-05 0.9999884855725604 1.0 1.0 68 O95684,Q3YEC7,P28074,P49356,Q9BRR6 5 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..43c42d6776dd41b130475d5ef296d3c7abf163a6 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACAT1", "ACAT2", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACVR1B", "ADAR", "ADD1", "ADD3", "ADGRE5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG2", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO10", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APC", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOB", "APOBEC3C", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF6", "ARFGAP1", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF1", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC5", "ARV1", "ASCC2", "ASCC3", "ASF1B", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BABAM1", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCL2L13", "BCLAF1", "BCOR", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD7", "BRD8", "BRD9", "BRI3BP", "BRIX1", "BROX", "BSG", "BTF3", "BTN2A1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C14orf2", "C17orf75", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C20orf27", "C2CD5", "C5orf15", "C5orf24", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALCOCO2", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CAND2", "CANT1", "CANX", "CAP1", "CAP2", "CAPN1", "CAPN2", "CAPN5", "CAPNS1", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASP2", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX4", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC25", "CCDC47", "CCDC6", "CCDC86", "CCNA2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD320", "CD3EAP", "CD46", "CD47", "CDC123", "CDC20", "CDC27", "CDC37", "CDC40", "CDC42", "CDC45", "CDC5L", "CDC73", "CDCA2", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKN2AIP", "CDS2", "CDV3", "CDYL", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPI", "CENPV", "CEP170", "CEP290", "CEP55", "CERK", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD3", "CHD4", "CHEK1", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2A", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTOP", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCC1", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLIP1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "CPD", "CPE", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF4", "CPSF6", "CPSF7", "CPT2", "CPVL", "CREG1", "CRKL", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC15", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF7", "DCAKD", "DCP2", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D4", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLG3", "DLGAP5", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DPF2", "DPH2", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DRG1", "DRG2", "DSC2", "DSC3", "DSG2", "DSP", "DTYMK", "DUSP12", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFL1", "EFTUD2", "EGFR", "EHD1", "EHD4", "EHMT1", "EHMT2", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERH", "ERLIN2", "ERP29", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC7", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM120B", "FAM136A", "FAM162A", "FAM177A1", "FAM208A", "FAM234B", "FAM3C", "FAM49B", "FAM50A", "FAM83D", "FAM91A1", "FAM98A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNBP4", "FNDC3A", "FNTB", "FOXC1", "FOXRED1", "FREM2", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GHITM", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLM1", "GOLM2", "GOLPH3L", "GOLT1B", "GOPC", "GORASP2", "GOT1", "GPAA1", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTPBP1", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS2", "HAUS3", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HERC2", "HEXA", "HGH1", "HIBCH", "HINT2", "HIP1", "HIRA", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN1", "HMGN2", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPSE", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "IAH1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFNGR1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INTS10", "INTS12", "INTS13", "INTS14", "INTS3", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRF2BP1", "IRGQ", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF18B", "KIF1A", "KIF1B", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLHDC4", "KMT2A", "KNOP1", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L3HYPDH", "LAMC1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGMN", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRP2", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM3", "LSM6", "LTA4H", "LTN1", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYN", "LYPLA1", "LYPLAL1", "LYSMD3", "LZIC", "LZTFL1", "LZTS2", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN1A1", "MAN2A1", "MAN2B1", "MANBA", "MAP1B", "MAP1S", "MAP2K1", "MAP2K4", "MAP4", "MAP4K5", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARCKS", "MARCKSL1", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MEAF6", "MECP2", "MECR", "MED1", "MED12", "MED16", "MED17", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL7A", "MFGE8", "MFN1", "MFSD3", "MFSD8", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRE11", "MRFAP1", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTMR2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVB12A", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "MYO9B", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NBR1", "NCAPD2", "NCAPH", "NCBP1", "NCDN", "NCK1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB1", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEFL", "NEFM", "NELFCD", "NELFE", "NES", "NEU1", "NF1", "NFATC2IP", "NFS1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME2", "NME3", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NUSAP1", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OTUB1", "OTUD4", "OTUD7B", "OXA1L", "P3H1", "P3H3", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PAM", "PANK4", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE4DIP", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF14", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHKA1", "PHPT1", "PI4K2A", "PI4KB", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIN1", "PIN4", "PINX1", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMS1", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLA2", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2E", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIL1", "PPIL3", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTK2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PXN", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB9A", "RABEP1", "RABEPK", "RABGAP1", "RABGGTB", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDH14", "RDX", "RECQL", "RECQL5", "REEP4", "REEP5", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF14", "RNF2", "RNF219", "RNF220", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRAGC", "RRAS2", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP130", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERINC1", "SERPINB1", "SERPINB6", "SERPINB8", "SERPINH1", "SET", "SETD1A", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL2", "SH3BGRL3", "SH3GL1", "SH3GLB1", "SH3PXD2B", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIN3A", "SIRT1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC33A1", "SLC35B2", "SLC35F2", "SLC38A2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A2", "SLC4A7", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMPDL3A", "SMS", "SMU1", "SMYD2", "SMYD3", "SMYD5", "SNAP23", "SNAP47", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPECC1", "SPECC1L", "SPEN", "SPPL2A", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRN", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TACO1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAP1", "TARBP1", "TARDBP", "TARS", "TARS2", "TAX1BP1", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBK1", "TBL1XR1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFIP11", "TFRC", "TGOLN2", "THADA", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM126A", "TMEM165", "TMEM167A", "TMEM192", "TMEM201", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM87A", "TMEM9", "TMEM97", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1B", "TOX4", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSR2", "TST", "TSTA3", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTI1", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TULP3", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAC14", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VLDLR", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR77", "WDR82", "WIPI2", "WIZ", "XAB2", "XPC", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YIPF3", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZDHHC13", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF346", "ZNF512B", "ZNF622", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAR2", "ACACA", "ACAT2", "ACOX1", "ACTR10", "ADGRE5", "ADPGK", "AHCYL1", "AKT1", "AKT2", "ALDH1B1", "ANAPC16", "ARHGAP17", "ARHGEF1", "ARL2", "ARMT1", "ARPC5", "ATAD5", "ATG4B", "ATP6V0A1", "ATP6V0A2", "ATP6V1C1", "BAIAP2", "BLMH", "BLVRA", "BRD7", "C17orf75", "CALCOCO2", "CAMK2G", "CAPN1", "CBFB", "CBL", "CCDC25", "CCNA2", "CCNB2", "CD2BP2", "CDC20", "CDK2", "CDK4", "CDK9", "CENPI", "CEP170", "CETN2", "CHAC2", "CHD3", "CHID1", "CNDP2", "CNN2", "CNN3", "COPA", "COPS3", "COPS8", "CREG1", "CSNK1A1", "CTPS1", "CTPS2", "CUTA", "CYFIP2", "DAD1", "DCTN3", "DCTPP1", "DDI2", "DDX24", "DDX3X", "DHX36", "DICER1", "DNAJA1", "DNAJA2", "DNAJC2", "DNAJC7", "DOHH", "DSC3", "DSP", "DUSP3", "DYNC1LI2", "EEF1E1", "EIF2B2", "EIF3B", "EIF3K", "EIF3M", "EIF5", "ELOA", "ELP3", "ERAP1", "ERC1", "ERCC2", "EXOC4", "EXOC7", "FAM49B", "FAM91A1", "FGFR1OP", "FHL1", "FKBP14", "FKRP", "FLII", "FNTB", "FOXC1", "GEMIN4", "GET4", "GLMN", "GNL3L", "GOLPH3L", "GSR", "GSTM3", "HLCS", "HMOX2", "HTT", "IDH1", "IGBP1", "ILK", "INA", "ITGAV", "JPT2", "JUP", "KARS", "KDELR1", "KIF18B", "KIF20B", "KNOP1", "KNTC1", "LANCL1", "LARP7", "LARS", "LRRC1", "LTN1", "LZIC", "LZTFL1", "LZTS2", "MCTS1", "MDN1", "ME1", "MED17", "MGEA5", "MIF", "MOV10", "MPP2", "MSTO1", "MTAP", "MTOR", "NAA15", "NAA40", "NAMPT", "NAP1L1", "NARS", "NCDN", "NES", "NME2", "NPEPPS", "NRBP1", "NTMT1", "NUBP2", "NUCB1", "NUFIP2", "NUP43", "OCLN", "ORC5", "OSBP", "OTUB1", "OTUD7B", "PAFAH1B2", "PANK4", "PBK", "PCM1", "PDAP1", "PDCD5", "PDCL3", "PDLIM3", "PEX19", "PHKA1", "PHPT1", "PIGU", "PIN1", "PIR", "PITPNA", "POLA2", "PPIL4", "PPP2R1A", "PPP2R1B", "PPP3CA", "PPP6R1", "PRC1", "PRKACA", "PRKCD", "PRMT5", "PRMT9", "PSMB5", "PSMB7", "PSMG1", "PSPH", "PTK2", "RAB1A", "RABL6", "RBM4", "RHOA", "RMDN3", "RPL10", "RPL17", "RPL19", "RPL27A", "RPL32", "RPL36A", "RPL4", "RPL8", "RPS10", "RPS17", "RPS23", "RPS6", "RPS8", "SCAMP4", "SERINC1", "SERPINB8", "SHMT1", "SHMT2", "SKP1", "SLC25A12", "SLC25A17", "SLC25A20", "SMN1*", "SMS", "SMYD2", "SMYD3", "SNX17", "SPART", "SPATA5", "SPC25", "SQLE", "SRPK2", "STAT1", "STAT3", "STRN", "SULT2A1", "SURF4", "SV2A", "SYNCRIP", "THOP1", "THYN1", "TIMM17B", "TMEM126A", "TMEM214", "TOM1", "TPP2", "TRAPPC11", "TSC2", "TSG101", "TTC37", "TTC38", "TTC4", "TUBB4A", "UBR4", "UBR5", "UFSP2", "UPF2", "UROD", "USP24", "USP47", "VLDLR", "WBP2", "WDR4", "WDR6", "WDR61", "WIPI2", "ZC3H7B"]} \ No newline at end of file