msigdb_reactome/result.tsv

Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
Transport of small molecules	0.4317436649343035	3.2361421483878936	0.001211570334777	0.807473665345089	0.1372103404134992	134	Q9BUN8,Q8WTV0,P35670,Q8N4V1,Q9UL46,Q9C0H2,P21796,P08183,Q9Y277,Q99808,P45880,P10644,Q9Y487,Q99797,P33527,Q93050,Q99436,O00487,Q06323,P28074,P40855,P35611,P30519,Q96TA2,Q70HW3,P63218,P28072,P53985,Q9UI12,O15118,Q10713,P60900,P49721,P02786,Q9Y5K8,Q9UJZ1,Q9HD20,Q9GZP9,Q8N8Q9,P49720,O75832,O00231,P09496,P28070,P35610	45
Cilium assembly	0.5294151358291964	2.946401990412163	0.0032149428497429	0.9874262709439194	0.1646444560974633	52	Q9Y496,P49368,A6NIH7,O75935,P62258,P07437,Q96A65,Q9H6D7,Q96KP1,O75695,P68371,O43924,Q13885,Q15154,Q10713,O94927,Q92973,O95684,P53350	19
Mitochondrial protein import	0.605870918091112	2.9085939036313917	0.0036305812447696	0.992866392561298	0.1646444560974633	35	O60830,Q99595,Q9UJS0,Q15388,Q9Y584,Q9NX63,Q9NS69,Q5JRX3,Q8N4H5,P21796,Q10713	11
Protein localization	0.4745445554607688	2.8225474270967936	0.0047643774546586	0.9984818492504376	0.1660202297661815	67	O43681,O60830,Q99595,Q9UJS0,Q15388,P50542,Q9Y584,Q9NS69,Q9NX63,P46379,O15254,Q8NBU5,Q5JRX3,Q8N4H5,P21796,Q10713,Q13011	17
Cargo recognition for clathrin mediated endocytosis	0.5736920433605102	2.4060789168678136	0.01612478102882	0.999999999745616	0.365226290302775	26	Q14108,P02786,P11717,Q7L5N1,Q9BT78,O43493,P20645,Q99627,P62993,P09496,Q92783,Q8NC96,Q9NVZ3	13
Kinesins	0.6148922785848825	2.396957441726844	0.0165318437213346	0.9999999998550392	0.3683077970048162	19	P33176,O00139,Q9NSK0,Q12756,P04350,P52732,Q9Y496,Q13885,Q9H0H5,Q9H0B6,Q14807,P68371,Q07866,O95235	14
Cargo trafficking to the periciliary membrane	0.6029619326965155	2.3545331227893667	0.0185459907624223	0.9999999999910616	0.400063515017968	20	Q96A65,P49368,A6NIH7,Q96KP1,Q10713,O43924	6
Pink1 prkn mediated mitophagy	0.8067322498218175	2.2683207240445524	0.0233096656919582	0.999999999999988	0.4202031867538676	7	Q9NS69,Q15388,P21796	3
Mitophagy	0.7399147720423125	2.2649862633590496	0.0235135224877209	0.999999999999991	0.4202031867538676	10	Q9NS69,Q15388,P21796	3
Sphingolipid metabolism	0.5599101574938946	2.260939118701579	0.023763027318773	0.9999999999999936	0.4202031867538676	25	O43681,Q96G23,P07602,O15269,P06865,P06280	6
Ras processing	0.8383498359546724	2.24184065219088	0.0249716728276834	0.9999999999999988	0.4202031867538676	6	O60725,P49356,P49354	3
Autophagy	0.4902805736641941	2.195049787093718	0.0281600265571153	1.0	0.4252164010124419	43	O60664,Q15388,P50542,Q9NS69,P49815,Q13885,Q9Y2Q5,Q9Y6G9,Q9Y4P1,Q8N4H5,P21796,P08670,P68371	13
Striated muscle contraction	0.9031791907514372	2.1820958009083196	0.0291024630554055	1.0	0.4346181021131441	5	Q9NYL9,P08670,P35609,P67936	4
Selective autophagy	0.5228448604733449	2.156864565888362	0.0310162185551492	1.0	0.4484153299622109	30	O60664,Q15388,P50542,Q9NS69,Q13885,Q9Y6G9,Q8N4H5,P21796,P08670,P68371	10
Mitochondrial calcium ion transport	0.5911093122323122	2.019272523015623	0.0434589021162454	1.0	0.5538578442236497	15	P45880,Q96TA2,Q9UJZ1,P21796,Q10713	5
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.7759760364475851	1.9730814654275148	0.0484862815866362	1.0	0.5883290774664167	6	Q9UIV1,Q9UKZ1,Q92600	3
Glycerophospholipid biosynthesis	0.5144268894177431	1.89142167399228	0.0585680775819779	1.0	0.617007887084558	24	O95674,Q9NPH0,P40939,Q8IV08,P35790,Q8NCC3	6
Aurka activation by tpx2	0.5079024712632487	1.882817392300592	0.0597251192163099	1.0	0.624357207807425	25	Q9H6D7,P62258,Q15154,O94927,O95684,O75935,P68371,P53350	8
Organelle biogenesis and maintenance	0.3843715706673242	1.8593611823518332	0.0629759600952299	1.0	0.6386890281299817	83	P49368,Q9Y496,A6NIH7,O75947,P00846,O75935,Q13505,P62258,Q96A65,Q9H6D7,Q96KP1,O75695,P68371,O43924,Q9NX63,Q15154,Q10713,Q92973,O94927,O95684,P53350	21
G alpha 12 13 signalling events	0.6952136887543865	1.8499637293858204	0.0643187774411262	1.0	0.6427148422241953	8	Q92974,Q14155,P63218	3
Gpcr ligand binding	0.6754614515900477	1.8443992158139888	0.0651249815234795	1.0	0.6460208021197716	9	P07602,P42892	2
Sphingolipid de novo biosynthesis	0.6527490474752681	1.8266362926918391	0.0677544727933068	1.0	0.6644673328668951	10	Q96G23	1
Abc family proteins mediated transport	0.4183365773246	1.8240749701425436	0.0681407389740011	1.0	0.6644673328668951	52	P28074,P40855,O00231,O75832,Q9GZP9,P28072,P33527,Q9UL46,P49720,Q99436,P08183,P60900,P28070,Q06323,P49721	15
Class a 1 rhodopsin like receptors	0.735305457018979	1.7937477839299507	0.0728534346545963	1.0	0.6652514858193948	6	P42892	1
Peptide ligand binding receptors	0.735305457018979	1.7937477839299507	0.0728534346545963	1.0	0.6652514858193948	6	P42892	1
Initiation of nuclear envelope ne reformation	0.5460569746576162	1.7845682188044905	0.0743313802762191	1.0	0.6652514858193948	16	P30153,Q9Y2U8,Q14739,P20700,P50402,P02545,P06493,P42167,O75531,P63151,Q14974,Q86XL3,P42166	13
Recruitment of mitotic centrosome proteins and complexes	0.4887860848348382	1.780176438766459	0.075047090047277	1.0	0.6652514858193948	26	O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P53350	8
Insertion of tail anchored proteins into the endoplasmic reticulum membrane	0.6434518802785667	1.7787060140485702	0.0752879726923971	1.0	0.6652514858193948	10	P46379	1
P75 ntr receptor mediated signalling	0.5521113701822322	1.777943599488204	0.0754131185090645	1.0	0.6652514858193948	15	P42574,Q92974,Q14155,P42575,P62258,Q14344,Q9NQC3,Q92769	8
E2f mediated regulation of dna replication	0.6430657174162213	1.7767106070001324	0.0756158662151431	1.0	0.6652514858193948	10	P30154,Q9UBD5,Q9Y619,P49642,Q14181,P06493	6
Iron uptake and transport	0.5353310548388622	1.7633293182989729	0.077844963263058	1.0	0.66956522199048	17	Q93050,Q9Y487	2
Anchoring of the basal body to the plasma membrane	0.482834468583859	1.7348898096321437	0.0827603244615757	1.0	0.684844134304833	26	Q9H6D7,P62258,Q15154,O94927,O95684,O75935,P68371,P53350	8
Purine salvage	0.7924235073897393	1.732700889605135	0.0831488463284013	1.0	0.684844134304833	5	P00813	1
Recruitment of numa to mitotic centrosomes	0.4651301460529257	1.7000861826775735	0.0891147159019516	1.0	0.7167477342164504	30	O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P07437,P53350	9
Transferrin endocytosis and recycling	0.6089470368790544	1.6976518103743377	0.0895734980161802	1.0	0.7167477342164504	11	P02786,Q9Y487,Q9Y5K8,Q93050,Q9UI12	5
Metabolism of porphyrins	0.6457307345310073	1.696083044966011	0.0898701541090463	1.0	0.7167477342164504	9	P33527,P22830	2
Early phase of hiv life cycle	0.6597686844668976	1.678982030305803	0.0931555459544135	1.0	0.7189675252140447	8	O75475	1
Synthesis of pg	0.9307109346806192	1.6727591412793428	0.0943747213536037	1.0	0.7189675252140447	2	Q8IV08	1
Nucleotide salvage	0.6763940991966231	1.6720381751288091	0.0945167945281433	1.0	0.7189675252140447	7	P00813	1
Signaling by insulin receptor	0.5336022738806189	1.661518128267348	0.0966094311348073	1.0	0.7219993589061975	15	Q9Y487,P31751,Q9Y5K8,Q93050,Q9UI12,P62993	6
Glycosphingolipid metabolism	0.533132121467762	1.658546148081872	0.0972072810128459	1.0	0.7219993589061975	15	O43681,P07602,Q9NZD2,Q9NXE4,P06865,P06280,P10619	7
Cell death signalling via nrage nrif and nade	0.6181390028168964	1.6471626088276328	0.0995246270636691	1.0	0.7311025307001426	10	Q92974,Q14155,P42575,P62258,Q14344,P42574	6
Signaling by hippo	0.7000361402240614	1.6358447305932662	0.1018720876978012	1.0	0.7355889251986396	6	Q13043,Q07157,P62258,Q4VCS5,P42574	5
Synthesis of pe	0.9191627571273888	1.6253287159029857	0.1040925358891873	1.0	0.7399460599152184	2	P35790	1
Fgfr1 mutant receptor activation	0.6660514479400123	1.623231901405252	0.1045398406944237	1.0	0.7399460599152184	7	O95429,O95684	2
Negative regulation of nmda receptor mediated neuronal transmission	0.7628305588847079	1.6096161264806284	0.1074816854445255	1.0	0.7452429108117866	5	P35609	1
Endosomal vacuolar pathway	0.8687906205855848	1.5919973947172372	0.1113852899402143	1.0	0.7683888783185344	4	P10321,Q9UIQ6	2
Visual phototransduction	0.6840702411289667	1.5637154590729991	0.1178844056487578	1.0	0.7913856894920174	6	P49354,P09455	2
Ion channel transport	0.4785686748836112	1.5619132141656982	0.118308435075165	1.0	0.7913856894920174	22	P35670,Q93050,Q9C0H2,Q9Y487	4
Rhoa gtpase cycle	0.4235860928111382	1.5337882994703762	0.1250817424019745	1.0	0.8172408073282856	41	Q96HY6,O15173,P30519,Q92974,Q14155,Q9H0H5,O75116,Q8NBN3,Q86UP2,P41440	10
Insulin receptor recycling	0.595837205045974	1.5301019183108455	0.1259915035059078	1.0	0.8192461878685585	10	Q9Y5K8,Q9UI12,Q93050,Q9Y487	4
Muscle contraction	0.4714802160248635	1.5103726707343743	0.1309483580671855	1.0	0.8394283896854015	22	Q9NYL9,P35609,O43865,P06753,Q05682,P08670,P67936	7
Synaptic adhesion like molecules	0.7379002661662768	1.505143979296634	0.1322870641775306	1.0	0.8400846739124493	5	P41440	1
Signaling by fgfr1 in disease	0.6227262646472878	1.49762974602841	0.1342294739119545	1.0	0.8484551397504473	8	O95429,P62993,O95684	3
Egfr downregulation	0.6674108497515125	1.4880772190701057	0.1367305305077835	1.0	0.8523706007343017	6	Q92783	1
Mitotic g2 g2 m phases	0.3568425686330683	1.4691953634360095	0.1417798075405514	1.0	0.8679223353495917	80	Q9UL46,P62258,O75935,P07437,Q99640,Q9H6D7,Q99436,P68371,Q06323,P28074,Q13885,Q15154,P28072,P60900,P49721,P49720,O94927,O95684,O00231,P28070,P53350	21
Miscellaneous transport and binding events	0.8359545426870129	1.4651063464905103	0.1428919054279815	1.0	0.8688256042000195	4	Q8N4V1,Q8N8Q9	2
Metabolism of folate and pterines	0.6158189283580521	1.4635530106654946	0.1433161194518493	1.0	0.8688256042000195	8	Q9H2D1,P41440	2
Ros and rns production in phagocytes	0.5994661592721333	1.4616202623934895	0.1438452987086125	1.0	0.8688256042000195	9	Q9Y5K8,Q9UI12,Q93050,Q9Y487	4
Switching of origins to a post replicative state	0.375535995743376	1.4469337573270828	0.1479154774120856	1.0	0.8720627455903112	54	P28074,Q14566,O00231,Q9UBD5,P28072,Q9Y619,Q9UJX3,Q9UL46,Q9UJX2,Q96DE5,Q99436,P49720,P60900,P28070,Q06323,P49721	16
Ire1alpha activates chaperones	0.4576059528675584	1.4385581972451975	0.1502757374108911	1.0	0.8720627455903112	23	P51858,Q9NWM8,P02545,O14773,P43307	5
Death receptor signalling	0.4571910703017004	1.4354783861274725	0.151150823117196	1.0	0.8720627455903112	23	P42574,Q92974,Q14155,P42575,O95429,Q8TCT8,O15111,P62258,Q9NQC3,Q92769	10
Depolymerisation of the nuclear lamina	0.6085677318163984	1.4277040325533816	0.1533770649965216	1.0	0.8720627455903112	8	P02545,Q9Y2U8,P20700,P42166	4
Tyrosine catabolism	0.8682785997834679	1.4158922201780426	0.1568070631027691	1.0	0.8720627455903112	2	P16930	1
Regulation of plk1 activity at g2 m transition	0.4309088697566262	1.4140956081787297	0.1573338324814956	1.0	0.8720627455903112	29	O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P53350	8
Polo like kinase mediated events	0.914488912515622	1.3996042509366775	0.1616318603089497	1.0	0.8720627455903112	3	P53350	1
Diseases of carbohydrate metabolism	0.5832435051391036	1.3785428768102437	0.168035739283495	1.0	0.8720627455903112	9	P46976,P13807,P54802,P10253,P08236	5
Activation of bad and translocation to mitochondria	0.580847521759794	1.3662430810761932	0.1718626796620075	1.0	0.8720627455903112	9	P27348,P31946,P31751,Q04917,P62258,P61981	6
Extra nuclear estrogen signaling	0.4873383789420765	1.3660997560534789	0.171907654870381	1.0	0.8720627455903112	15	P31751,P04899,P04792	3
Dap12 interactions	0.7029433765261806	1.357742265727352	0.1745454803532502	1.0	0.8720627455903112	5	P62993,P10321,P01889	3
Inhibition of replication initiation of damaged dna by rb1 e2f1	0.6371243623811852	1.34976427601421	0.1770916073006976	1.0	0.8720627455903112	6	P30153,Q14181,P49642,P30154	4
Mitotic metaphase and anaphase	0.3106684214461442	1.3454017304612194	0.1784955367415426	1.0	0.8720627455903112	125	P37198,Q7Z3B4,Q9UL46,Q8NBT2,Q29RF7,P52948,P02545,Q9Y6G9,Q9UJX3,Q99436,P68371,O00487,Q86XL3,Q06323,P28074,Q9Y2U8,P20700,Q13885,Q9BZD4,P28072,Q9UJX2,Q53HL2,P60900,P49721,Q8N1F7,Q96DE5,P49720,Q92973,O75832,O00231,Q2NKX8,P28070,P53350,P42166	34
Phospholipid metabolism	0.4131431159196504	1.3440999718271545	0.1789160612253937	1.0	0.8720627455903112	36	O95674,Q9UG56,Q9NPH0,P40939,Q8IV08,Q10713,P35790,Q8NCC3	8
Synthesis of dna	0.3476967523865489	1.3414052273314765	0.1797889213249848	1.0	0.8720627455903112	79	Q14566,Q9UL46,Q9UBD5,Q9NR33,Q9UJX3,Q99436,Q06323,P41440,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070	22
Long term potentiation	0.8029918649160946	1.337247965943343	0.1811417096523642	1.0	0.8720627455903112	4	P35609	1
Unblocking of nmda receptors glutamate binding and activation	0.8029918649160946	1.337247965943343	0.1811417096523642	1.0	0.8720627455903112	4	P35609	1
Ras activation upon ca2 influx through nmda receptor	0.8029918649160946	1.337247965943343	0.1811417096523642	1.0	0.8720627455903112	4	P35609	1
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1	0.3957324606796455	1.3288951082701814	0.1838825779344761	1.0	0.8720627455903112	44	P28074,P28072,Q96DE5,Q9UJX3,Q9UL46,Q9UJX2,P49720,Q99436,O00231,P60900,P28070,P53350,Q06323,P49721	14
Signaling by alk	0.695104563652327	1.32458741696776	0.1853080316303175	1.0	0.8720627455903112	5	Q96ST3,Q92769	2
The role of gtse1 in g2 m progression after g2 checkpoint	0.3814525399569697	1.318311159357518	0.1873995068055332	1.0	0.8751887559473193	49	P28074,Q13885,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,P53350,Q06323,P49721	13
Cytoprotection by hmox1	0.3483170826445494	1.3183023671938765	0.1874024488452317	1.0	0.8751887559473193	62	P28074,P30519,P28072,P33527,Q96ST3,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	13
Dna replication initiation	0.6294667043548737	1.3146678463932198	0.1886215572864578	1.0	0.8778653984667676	6	Q9NR33,P49642	2
Phase i functionalization of compounds	0.5014260087439046	1.3024187049540106	0.1927732917755025	1.0	0.8850638632530673	13	O43169,Q16850	2
Antigen processing cross presentation	0.3759959374101491	1.2936054751448245	0.1958017303074619	1.0	0.8899483327352534	50	P28074,Q06323,P10321,O75832,O15111,P28072,Q9UL46,P49720,P49721,Q99436,O00231,O00487,P60900,P28070,P01889,Q9UIQ6	16
S phase	0.3375606598905507	1.2874430147424196	0.1979399197172004	1.0	0.8933055647597645	89	Q14566,Q9UL46,Q29RF7,P31751,Q9UBD5,Q9NR33,Q9UJX3,Q99436,P41440,Q06323,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070	24
Cdt1 association with the cdc6 orc origin complex	0.4001388651799941	1.285262907078342	0.1987004275025128	1.0	0.8933055647597645	39	P28074,O75832,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Suppression of phagosomal maturation	0.6159042380682587	1.25242852578372	0.2104137573362172	1.0	0.8964021825075839	6	Q9UI12,P20339,P52294,Q14974	4
Response to elevated platelet cytosolic ca2	0.4080739649920089	1.2328107168187543	0.2176463920572364	1.0	0.9073050515514858	30	P07602,O43852,P12814,Q8NBX0,Q9NUQ9,Q9Y6I9,Q9NTK5,P35609	8
Cdc6 association with the orc origin complex	0.8206423673763952	1.220292595404201	0.2223539757781476	1.0	0.920920397623056	2	Q9UBD5	1
Cooperation of prefoldin and tric cct in actin and tubulin folding	0.4528152153789945	1.2130456220944894	0.2251123783819137	1.0	0.920920397623056	17	P61758,O15212,P04350,P49368,Q13885,Q9UHV9,Q99471,P68371	8
Smac xiap regulated apoptotic response	0.8163118007939322	1.202596757673259	0.2291324029976327	1.0	0.920920397623056	2	Q9NR28	1
Heme degradation	0.6655211070730508	1.1993303693460762	0.2303995108107719	1.0	0.920920397623056	5	P33527	1
Trafficking of myristoylated proteins to the cilium	0.8568612873120255	1.186650780550551	0.2353653968845492	1.0	0.9224797998370938	3	A6NIH7	1
Egr2 and sox10 mediated initiation of schwann cell myelination	0.7630845725312898	1.182397597531136	0.2370479760308659	1.0	0.9224797998370938	4	P46939,Q16850	2
Myoclonic epilepsy of lafora	0.8094550703717056	1.174622854940631	0.2401456354502693	1.0	0.9224797998370938	2	P46976	1
Orc1 removal from chromatin	0.3699308362772668	1.1685315735676292	0.2425924111198432	1.0	0.9224797998370938	48	P28074,Q14566,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	13
Nrage signals death through jnk	0.5957201075480983	1.1597137782201097	0.2461653585789247	1.0	0.92328932169684	6	Q14155	1
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components	0.8482967853220689	1.1551484534241427	0.2480296391186116	1.0	0.92328932169684	3	Q15404	1
Mastl facilitates mitotic progression	0.6549855570094427	1.1547346562585998	0.2481991029580903	1.0	0.92328932169684	5	P06493,P30154,O43768	3
Clathrin mediated endocytosis	0.3728076486750227	1.146817465751418	0.2514570691460269	1.0	0.9276669404766068	46	Q14108,P02786,P11717,Q7L5N1,P62993,Q9BT78,O43493,P20645,Q99627,Q14C86,Q9NVZ3,Q92783,Q8NC96,P20339	14
Intraflagellar transport	0.523299625688935	1.1441397462370897	0.2525656865168098	1.0	0.9276669404766068	10	Q9Y496,Q13885,P68371,Q92973	4
Mapk family signaling cascades	0.3278989945627075	1.1420646273794397	0.2534271572723872	1.0	0.9283221205745934	88	P49356,P41240,Q9UL46,O60725,Q9Y2Q5,Q96S59,P49354,Q99436,O00487,O43924,Q13813,Q06323,P28074,Q99956,Q14168,P28072,P62993,P60900,P35609,P04792,P49721,P20936,P07196,P49720,O75832,O00231,P28070	27
Sulfur amino acid metabolism	0.5221040691188797	1.1377471968247277	0.2552260594580049	1.0	0.9323984268909372	10	Q9BV57,Q13126	2
Phenylalanine and tyrosine metabolism	0.6505454046398697	1.1359522089465166	0.2559765661824236	1.0	0.9326331191472216	5	P61457,P16930	2
Signaling by the b cell receptor bcr	0.3679088439865423	1.121364944328335	0.2621325515915083	1.0	0.9474418553533503	47	P28074,O95999,O75832,O43865,O15111,P62993,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	16
Abc transporter disorders	0.3770995503768387	1.1111874734799876	0.2664876619870888	1.0	0.9505426053555216	42	P28074,Q9BUN8,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Defective cftr causes cystic fibrosis	0.3770995503768387	1.1111874734799876	0.2664876619870888	1.0	0.9505426053555216	42	P28074,Q9BUN8,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Regulation of pten stability and activity	0.3732410773424209	1.1085914180591707	0.2676064819985257	1.0	0.9520345786282632	44	P28074,P31751,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721	14
Carboxyterminal post translational modifications of tubulin	0.581834563977945	1.0959639928458909	0.2730945323142193	1.0	0.9552795682710872	6	P04350,P68371,Q13885	3
Regulation of ras by gaps	0.3790448263342693	1.0904666561767844	0.2755076335815247	1.0	0.9552795682710872	39	P28074,O75832,P20936,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex	0.5118025554226426	1.0826820124055505	0.2789495907619643	1.0	0.9552795682710872	10	P27348,P31946,P06493,Q04917,P62258,P61981	6
M phase	0.3108579850389646	1.0822826732860442	0.2791269426127054	1.0	0.9552795682710872	171	Q9Y6X3,P37198,P42166,P30154,Q7Z3B4,Q9UL46,Q8NFH4,O75935,P62258,P07437,O60763,Q8NBT2,Q29RF7,Q9H6D7,P52948,P02545,Q9Y6G9,Q9UJX3,Q99436,O00487,Q86XL3,P68371,O95235,Q06323,P28074,Q9Y2U8,P20700,Q9BTX1,Q9BSJ2,Q13885,Q9BZD4,Q15154,P28072,Q9UJX2,Q53HL2,P60900,P49721,P20618,Q92973,Q01105,O75832,Q99567,Q8N1F7,Q96DE5,P49720,O94927,O95684,O00231,Q2NKX8,P28070,P53350,P61981	52
Auf1 hnrnp d0 binds and destabilizes mrna	0.3735524132562772	1.0772418453704895	0.2813722353147005	1.0	0.9552795682710872	42	P28074,P28070,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P04792,Q06323,P49721	11
Rhobtb gtpase cycle	0.3936754919163712	1.0731900650136743	0.2831858473526294	1.0	0.9552795682710872	27	P61201,P62995,P78371,Q9NYL9,P12814,Q8N684,O75116,Q12792,Q9BT78,Q16543,P08670	11
Ion transport by p type atpases	0.5371119103553188	1.0719229235424674	0.2837546529807722	1.0	0.9552795682710872	8	P35670	1
Tbc rabgaps	0.4788461019781303	1.0674465880400696	0.2857702204392769	1.0	0.9552795682710872	12	P49815,Q9Y3P9	2
Deubiquitination	0.3243698459235916	1.06000322473262	0.2891431322728388	1.0	0.9552795682710872	84	P28074,P45880,Q96RU2,O00231,Q15388,Q7Z434,P28072,Q96K76,Q9UL46,P21796,Q8NB78,P28070,Q92783,P49721	14
Apc c mediated degradation of cell cycle proteins	0.3540777558338561	1.0599721276623963	0.2891572797359167	1.0	0.9552795682710872	50	P28074,P28072,Q96DE5,Q9UJX3,Q9UL46,Q9UJX2,P49720,Q99436,O00231,P60900,P28070,P53350,Q06323,P49721	14
Regulation of localization of foxo transcription factors	0.5479057057359368	1.0564943294310631	0.2907424301894119	1.0	0.9552795682710872	7	P27348,P31946,P63104,P31751,P61981	5
Gaba receptor activation	0.5730357682743301	1.0556229195986244	0.2911405253759764	1.0	0.9552795682710872	6	P04899,P63218	2
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps	0.4428697467487617	1.0503380543244607	0.2935627150325917	1.0	0.9552795682710872	14	Q9BTY2,Q07065,Q86UP2,O43852	4
Factors involved in megakaryocyte development and platelet production	0.3739063497949217	1.0429779509175208	0.2969585047917731	1.0	0.9552795682710872	39	P33176,Q9Y496,Q96ST3,Q92769,P20339,O00139,P47756,P10644,Q9H0B6,Q14807,P68371,Q07866,O95235,P04350,Q13885,P45973,Q9NSK0,P52732,Q9H0H5,O95140	20
Nade modulates death signalling	0.8166064981949442	1.0392425342293998	0.2986919533367924	1.0	0.9552795682710872	3	P62258,P42575	2
Ub specific processing proteases	0.3265225101077251	1.0377485063504328	0.2993871558631611	1.0	0.9552795682710872	68	P28074,P45880,Q96RU2,Q96K76,P28072,Q9UL46,P21796,O00231,P28070,P49721	10
Regulation of runx3 expression and activity	0.3748092136108091	1.0335685197046247	0.3013379225619084	1.0	0.9552795682710872	38	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Sensory perception	0.4056620276709347	1.0263595999651762	0.3047221136517009	1.0	0.9552795682710872	22	P49354,P09455	2
Gamma carboxylation hypusine formation and arylsulfatase activation	0.5138133211953216	1.020742127085189	0.3073766298685003	1.0	0.9552795682710872	9	O43681,P38435,O60725	3
G beta gamma signalling through pi3kgamma	0.622662472554357	1.0183269193691724	0.3085226195669279	1.0	0.9552795682710872	5	P31751	1
Signaling by fgfr4 in disease	0.7704799711295538	1.0170119152845205	0.3091477611639106	1.0	0.9552795682710872	2	P62993	1
Cyclin a cdk2 associated events at s phase entry	0.36716986325973	1.0161841518896455	0.3095417017991371	1.0	0.9552795682710872	42	P28074,P20618,P31751,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Signaling by hedgehog	0.3302936732365319	1.0145591375623493	0.3103160260958422	1.0	0.9552795682710872	56	P28074,P10644,Q9Y496,Q13885,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,Q06323,P49721	15
Glycogen storage diseases	0.8097472924187707	1.014331046314792	0.3104248145253809	1.0	0.9552795682710872	3	P46976,P10253	2
Signaling by egfr	0.4830463167973628	1.0044029593638657	0.3151844241700101	1.0	0.9552795682710872	11	P41240,P62993,Q14155,Q92783	4
Translocation of slc2a4 glut4 to the plasma membrane	0.3764988638663834	0.9965246543378296	0.3189952942017446	1.0	0.9552795682710872	34	Q96A65,P31751,Q9Y496,Q96KP1,P62258,P68371,Q9UIQ6	7
Plasma lipoprotein clearance	0.4815662690603202	0.9962194838425498	0.3191435146407899	1.0	0.9552795682710872	11	Q8WTV0	1
Methionine salvage pathway	0.6173530498819384	0.9960223578796712	0.3192392821172072	1.0	0.9552795682710872	5	Q9BV57	1
Copi dependent golgi to er retrograde traffic	0.359690273492137	0.994159849239834	0.3201450518202504	1.0	0.9552795682710872	45	O00139,P54920,Q9NSK0,P48444,O14579,Q6NUQ1,P24390,P35606,P52732,Q9Y496,Q13885,Q9P2W9,Q9H0H5,Q9H0B6,Q14807,P68371,Q07866,O95235	18
Dna replication	0.3192924082549064	0.990710034383573	0.3218271898949343	1.0	0.9552795682710872	84	Q14566,Q9UL46,Q9UBD5,Q9NR33,Q9UJX3,Q99436,Q06323,P41440,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070	22
Stat3 nuclear events downstream of alk signaling	0.7133255303784554	0.9906801272644068	0.3218417978584607	1.0	0.9552795682710872	4	Q96ST3	1
Unwinding of dna	0.4805562572335016	0.9906368888880008	0.3218629181645411	1.0	0.9552795682710872	11	Q14566,Q14691	2
Dna replication pre initiation	0.32112897535292	0.9848475391000772	0.3246989653847139	1.0	0.9552795682710872	61	P28074,Q14566,Q9UBD5,P28072,Q9NR33,Q9UL46,P49642,Q9Y619,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	15
Hedgehog ligand biogenesis	0.3647200061399732	0.9794746559370946	0.3273455052097231	1.0	0.9552795682710872	41	P28074,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Degradation of dvl	0.368737224752957	0.978274941063237	0.3279383602464794	1.0	0.9552795682710872	38	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Rho gtpase cycle	0.2932346939569589	0.9771714219807436	0.3284842935718177	1.0	0.9552795682710872	136	O15173,Q9UQB8,P06753,O75976,Q9UNZ2,Q16543,Q13505,Q96HY6,Q8NBN3,Q07065,Q86XL3,Q13813,P41440,O75489,P20700,P30519,Q9NYL9,P08670,P62993,P67936,Q86UP2,Q92783,Q92974,Q14155,Q9H0H5,P12814,O75116,Q9BT78,P42166	29
Antigen activates b cell receptor bcr leading to generation of second messengers	0.7989560475587023	0.9752982681180024	0.3294123293173787	1.0	0.9552795682710872	3	O43865	1
Neurotransmitter clearance	0.7596535546733985	0.973791091198303	0.3301602773994836	1.0	0.9552795682710872	2	P21964	1
Degradation of axin	0.369657923867354	0.971565630438959	0.3312666879270325	1.0	0.9552795682710872	37	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Cross presentation of soluble exogenous antigens endosomes	0.369657923867354	0.971565630438959	0.3312666879270325	1.0	0.9552795682710872	37	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Rho gtpases activate ktn1	0.5039297982842845	0.969925136261349	0.332083809709649	1.0	0.9552795682710872	9	Q07866,Q86UP2,Q9H0B6	3
Signaling by cytosolic fgfr1 fusion mutants	0.6110249088681894	0.9694918754726378	0.3322998319104338	1.0	0.9552795682710872	5	O95684	1
Activation of bh3 only proteins	0.4763870081759936	0.9676107465824232	0.3332388081419242	1.0	0.9552795682710872	11	P27348,P31946,P31751,Q04917,P62258,P61981	6
Disorders of transmembrane transporters	0.3207621747251518	0.9662788881571802	0.3339046472492257	1.0	0.9552795682710872	73	Q9BUN8,Q7Z3B4,Q9UL46,P52948,Q99436,O00487,Q06323,P28074,Q9BTX1,P28072,P53985,P60900,P49721,P20618,Q9GZP9,Q8N1F7,P49720,O75832,O00231,P28070,P37198	21
Fcgamma receptor fcgr dependent phagocytosis	0.3786495372200461	0.953609733805536	0.3402812267817217	1.0	0.9594236248887132	27	Q9UQB8	1
Cdc42 gtpase cycle	0.3852969472081487	0.9480461167298928	0.3431059774503691	1.0	0.959696610167494	25	Q9UQB8,Q14155	2
Transport of connexons to the plasma membrane	0.6047812149383192	0.9433803748897848	0.3454863776486463	1.0	0.959696610167494	5	P04350,P68371,Q13885	3
Gap junction assembly	0.6047812149383192	0.9433803748897848	0.3454863776486463	1.0	0.959696610167494	5	P04350,P68371,Q13885	3
Nuclear envelope ne reassembly	0.3523563682019314	0.9409438124091444	0.3467336538574241	1.0	0.959696610167494	46	Q14739,Q7Z3B4,Q8NFH4,P06493,P57740,P30153,P52948,Q8NFH5,P02545,Q9BVL2,P68371,Q86XL3,Q9Y2U8,P20700,Q9BTX1,P04350,Q13885,P53990,Q9BVA1,Q14974,Q8N1F7,Q92973,P37198,P42166	24
Smooth muscle contraction	0.4709104163912131	0.9374155485122504	0.348544846027826	1.0	0.9604319507325896	11	P06753,Q05682,P67936	3
Mucopolysaccharidoses	0.6975530366173986	0.930601723492214	0.352059622651617	1.0	0.9604319507325896	4	P08236,P54802	2
Tcr signaling	0.3469410231063541	0.9305474728756012	0.3520876964995496	1.0	0.9604319507325896	48	P28074,P20618,O95999,O75832,P41240,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,P19174,Q06323,P49721	17
Signaling by erbb4	0.5205282798557334	0.9250477953895088	0.3549410463740641	1.0	0.9604319507325896	7	P61201,P62993,P46934,P16949	4
Hedgehog on state	0.3574441255489828	0.9233098290077496	0.3558457671426684	1.0	0.9604319507325896	42	P28074,O75832,Q9Y496,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Asymmetric localization of pcp proteins	0.3615506600102837	0.9129660618135248	0.3612603911290968	1.0	0.9623109060947864	38	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Signaling by ntrk3 trkc	0.6912242686890413	0.9066312647091306	0.3646018227394769	1.0	0.9623109060947864	4	Q8WX92,P62993,P19174	3
Antigen presentation folding assembly and peptide loading of class i mhc	0.4330990615877851	0.8901359917940351	0.3733928690463268	1.0	0.9712074284278646	13	P10321,Q9NZ08	2
Hedgehog off state	0.3380687839841637	0.88945013587664	0.3737612104987293	1.0	0.9712074284278646	50	P28074,P10644,Q9Y496,Q13885,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,Q06323,P49721	14
Stabilization of p53	0.3561335536171667	0.8880170353943357	0.3745315878657727	1.0	0.9713519616595137	40	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Signaling by ptk6	0.4155613464520847	0.8781855073220997	0.3798430555918761	1.0	0.97950513517174	14	P18031,Q07666,P11802,P31749,P23246,Q96JJ3,Q8IZL8,P20936	8
Transcriptional regulation by runx3	0.3524157955589958	0.8754340936277187	0.3813377558815283	1.0	0.97950513517174	42	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Vegfr2 mediated cell proliferation	0.7707581227436799	0.8744212529533144	0.3818888874883686	1.0	0.97950513517174	3	P20936,O43865	2
Role of phospholipids in phagocytosis	0.7707581227436792	0.8744212529533127	0.3818888874883694	1.0	0.97950513517174	3	Q8IV08,O43865	2
Rac3 gtpase cycle	0.3645508029846798	0.8718402111118057	0.3832955544875189	1.0	0.97950513517174	29	Q9UQB8,Q9H0H5	2
Downstream signaling events of b cell receptor bcr	0.3487299961717887	0.8685973782337915	0.3850673890017408	1.0	0.97950513517174	44	P28074,O95999,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Rhobtb1 gtpase cycle	0.3965058361151227	0.8654008617539432	0.3868188081854571	1.0	0.97950513517174	18	P61201,P62995,P78371,Q8N684,O75116,Q9BT78,P08670	7
G protein beta gamma signalling	0.5308322068720335	0.8635521593141593	0.3878339545482001	1.0	0.9796772197602304	6	P31751	1
Transcriptional regulation by e2f6	0.5299642708574875	0.859640423231339	0.3899872849870145	1.0	0.9804730857633908	6	Q13185	1
Diseases of signal transduction by growth factor receptors and second messengers	0.2847570309207412	0.8585906433848457	0.3905664020489836	1.0	0.9804730857633908	132	Q9P2E9,P41240,O95429,P06753,Q9UL46,Q16543,Q92769,P10644,P31751,P02545,O43815,Q99436,O00487,Q07866,Q06323,P28074,P51114,Q99956,Q6UN15,O15111,P28072,P62993,P67936,P60900,P49721,Q14789,O75832,Q9GZP9,P06748,P49720,Q9NRY5,O95684,O00231,P49815,P28070	35
G alpha s signalling events	0.5295379112538994	0.8577195996748779	0.3910473147178304	1.0	0.9804730857633908	6	P04899	1
Metalloprotease dubs	0.5288687233291758	0.854705806634151	0.3927140351485665	1.0	0.9804730857633908	6	O95630,O00487,Q92783	3
Metabolism of lipids	0.294634877690084	0.8541877222233819	0.3930009849211004	1.0	0.9804730857633908	161	O15254,Q8N8N7,O43772,Q96ST3,Q15392,P38435,P35790,Q8NCC3,Q16850,P06865,P06280,P23786,P20339,Q96G23,P37268,Q9NPH0,P40939,P50897,P33527,Q9UMR5,Q8IV08,O43681,O95674,P07602,O15269,Q15165,Q10713,Q9UG56,Q06520	29
Gaba b receptor activation	0.5808697435002625	0.8441363441109281	0.3985932205712597	1.0	0.9804730857633908	5	P04899	1
G alpha z signalling events	0.5808697435002625	0.8441363441109281	0.3985932205712597	1.0	0.9804730857633908	5	P04899	1
Adp signalling through p2y purinoceptor 12	0.5808697435002625	0.8441363441109281	0.3985932205712597	1.0	0.9804730857633908	5	P04899	1
Regulation of runx2 expression and activity	0.3489717044711322	0.8427218521636006	0.3993840228708967	1.0	0.9804730857633908	42	P28074,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721	13
G1 s dna damage checkpoints	0.350082525295017	0.8417219268712013	0.3999436218107099	1.0	0.9804730857633908	41	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
E2f enabled inhibition of pre replication complex formation	0.6735194539553172	0.8400718680231779	0.4008680922262218	1.0	0.9804730857633908	4	Q9Y619,Q9UBD5	2
Negative regulation of notch4 signaling	0.349878242128814	0.839807360424607	0.4010164058850618	1.0	0.9804730857633908	41	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Metabolism of polyamines	0.3513054966874797	0.8348925793002087	0.4037781932911057	1.0	0.9804730857633908	39	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Fc epsilon receptor fceri signaling	0.3245641525517961	0.8337831770787906	0.4044031768816483	1.0	0.9804730857633908	53	P28074,P20618,O95999,O75832,O43865,O15111,P62993,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,P19174,Q06323,P49721	18
Scf skp2 mediated degradation of p27 p21	0.3499327745579542	0.8305046318315119	0.4062535301423613	1.0	0.9804730857633908	40	P28074,P20618,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Hs gag degradation	0.7577617328519823	0.828590903503616	0.4073359370653922	1.0	0.9804730857633908	3	P08236,P54802	2
Heparan sulfate heparin hs gag metabolism	0.7577617328519823	0.828590903503616	0.4073359370653922	1.0	0.9804730857633908	3	P08236,P54802	2
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling	0.4879261245555952	0.828297005195727	0.4075023184697437	1.0	0.9804730857633908	8	P35609	1
Cooperation of pdcl phlp1 and tric cct in g protein beta folding	0.4367667331435709	0.825826874761259	0.4089023066549795	1.0	0.9804730857633908	12	P49368	1
Phosphorylation of the apc c	0.4749744418125619	0.8221718003285011	0.4109791258127715	1.0	0.9807774124363088	9	Q96DE5,Q9UJX3,P53350	3
Rhob gtpase cycle	0.3891987161997547	0.8155268413614828	0.4147708068005893	1.0	0.9807774124363088	18	Q92974,Q9H0H5,P41440	3
Sealing of the nuclear envelope ne by escrt iii	0.4735207465572593	0.8148166142474041	0.415177289336212	1.0	0.9807774124363088	9	P04350,P68371,Q13885,P53990	4
Aryl hydrocarbon receptor signalling	0.7515805195955418	0.8069668134699157	0.4196856032794807	1.0	0.9807774124363088	3	O00170	1
Plasma lipoprotein assembly remodeling and clearance	0.4190924630150635	0.8067283247890307	0.4198230215021872	1.0	0.9807774124363088	13	Q8WTV0	1
Nuclear envelope breakdown	0.3497702779044484	0.8064458890844179	0.4199857963909996	1.0	0.9807774124363088	38	P35658,Q7Z3B4,Q8NFH4,P12270,P06493,P57740,P52948,Q8NFH5,P02545,Q9BVL2,O75531,Q9Y2U8,P20700,Q9BTX1,Q99567,Q8N1F7,P53350,P37198,P42166	19
Assembly and cell surface presentation of nmda receptors	0.4593914117392615	0.804806857773664	0.4209311436817504	1.0	0.9807774124363088	10	Q13885,Q14168,P07196,P68371,P35609	5
Retrograde transport at the trans golgi network	0.3956274544643695	0.800078176467852	0.4236655044584609	1.0	0.9807774124363088	16	O60664,O43493,P11717,P83436,P53365,P20645,Q9UID3	7
Amino acid transport across the plasma membrane	0.7134608444604795	0.7934790648426521	0.4274987618567412	1.0	0.9807774124363088	2	P08195	1
Nuclear signaling by erbb4	0.7476534296028855	0.7932910963553578	0.4276082430771855	1.0	0.9807774124363088	3	P61201,P16949	2
Regulation of hmox1 expression and activity	0.3406477494645241	0.7900478479449532	0.4294998252938717	1.0	0.9807774124363088	44	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Nephrin family interactions	0.4686094473589817	0.7900244483400132	0.4295134904497848	1.0	0.9807774124363088	9	P12814,P35609,Q13813	3
Traf6 mediated nf kb activation	0.658182346033841	0.78311552933125	0.4335592726328965	1.0	0.9807774124363088	4	Q7Z434	1
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10	0.7442704097318975	0.78155081928733	0.4344785995774731	1.0	0.9807774124363088	3	Q7Z434	1
Cyclin a b1 b2 associated events during g2 m transition	0.4549264152544991	0.7814908879339763	0.4345138339120544	1.0	0.9807774124363088	10	P53350	1
Insulin processing	0.4768181017009016	0.7740878100063732	0.4388788656464371	1.0	0.9807774124363088	8	Q96KP1	1
Constitutive signaling by ligand responsive egfr cancer variants	0.6555161457297698	0.7732907043041202	0.4393503558848346	1.0	0.9807774124363088	4	P62993,Q16543	2
Signaling by erbb2 ecd mutants	0.6555161457297698	0.7732907043041202	0.4393503558848346	1.0	0.9807774124363088	4	P62993,Q16543	2
Constitutive signaling by egfrviii	0.6555161457297698	0.7732907043041202	0.4393503558848346	1.0	0.9807774124363088	4	P62993,Q16543	2
Signaling by erbb2 in cancer	0.6555161457297698	0.7732907043041202	0.4393503558848346	1.0	0.9807774124363088	4	P62993,Q16543	2
Signaling by egfr in cancer	0.6555161457297698	0.7732907043041202	0.4393503558848346	1.0	0.9807774124363088	4	P62993,Q16543	2
Rac1 gtpase cycle	0.3506905065619928	0.7688749937019165	0.4419675236067055	1.0	0.9807774124363088	33	Q9UQB8,Q14155	2
The phototransduction cascade	0.7394921381118253	0.7650353290941115	0.4442505074845004	1.0	0.9807774124363088	3	P49354	1
Mitotic prometaphase	0.3044117093458539	0.7637606632912461	0.4450098825241604	1.0	0.9807774124363088	78	Q8NBT2,Q29RF7,Q9H6D7,P62258,Q9BZD4,Q15154,Q9Y6G9,O94927,O95684,O75935,P68371,Q2NKX8,P07437,P53350,Q53HL2	15
Signaling by pdgfr in disease	0.5586644396891991	0.7534102825191136	0.4512034057251706	1.0	0.9807774124363088	5	P62993,O43815	2
Fceri mediated nf kb activation	0.3343178975933114	0.7438235212852097	0.4569832482630422	1.0	0.9807774124363088	45	P28074,P20618,O95999,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	15
Platelet aggregation plug formation	0.503969318753252	0.7435999560267049	0.4571185298488744	1.0	0.9807774124363088	6	P41240,P18031,P62993,P31749	4
Integrin signaling	0.503969318753252	0.7435999560267049	0.4571185298488744	1.0	0.9807774124363088	6	P41240,P18031,P62993,P31749	4
Transcriptional regulation by runx2	0.3190202711350715	0.7417817263433037	0.4582195939414215	1.0	0.9807774124363088	52	P28074,P20618,P31751,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721	15
Tnfr2 non canonical nf kb pathway	0.3380232165272532	0.7393205440240809	0.459712377285467	1.0	0.9807774124363088	42	P28074,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Dectin 1 mediated noncanonical nf kb signaling	0.3380232165272531	0.7393205440240801	0.4597123772854674	1.0	0.9807774124363088	42	P28074,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Formation of the early elongation complex	0.4211285068553096	0.7375869809460672	0.4607654691645129	1.0	0.9807774124363088	12	Q8WX92,Q8IXH7	2
Signaling by vegf	0.3488854152154302	0.7196822063404871	0.4717206842995665	1.0	0.9832669046317036	27	P31751,Q9UQB8,P04792	3
Mitotic g1 phase and g1 s transition	0.3015124015853728	0.7193598850757305	0.471919206739736	1.0	0.9832669046317036	74	Q14566,P11802,Q9UL46,P31751,Q9UBD5,Q9NR33,Q99436,O00487,Q06323,P28074,P28072,P49642,P60900,P49721,P20618,Q9Y619,Q14181,P49720,O75832,O00231,P28070	21
Signaling by notch4	0.3343745865311683	0.716403410393116	0.4737422897209762	1.0	0.9832669046317036	43	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Notch4 activation and transmission of signal to the nucleus	0.6871165644171728	0.6946535785385253	0.4872724264331398	1.0	0.997403001456385	2	Q92542	1
Listeria monocytogenes entry into host cells	0.4710361531248672	0.6921101667177527	0.4888681474989853	1.0	0.9990553570693548	7	Q92783	1
Mitotic telophase cytokinesis	0.4221823167642943	0.6733526812972797	0.5007229447520423	1.0	1.0	11	Q9Y6X3,Q29RF7,P53350	3
Abortive elongation of hiv 1 transcript in the absence of tat	0.421971250936782	0.6722355848095012	0.5014337303417122	1.0	1.0	11	Q8WX92,Q8IXH7	2
Activation of the pre replicative complex	0.3627938954735742	0.667003329321934	0.5047700068064471	1.0	1.0	19	Q14566,Q9UBD5,Q9Y619,Q9NR33,P49642	5
Synthesis of pa	0.5361590230538711	0.663410374395538	0.507067763354035	1.0	1.0	5	Q9NPH0	1
Peptide hormone metabolism	0.4075620704073803	0.6622000141913303	0.5078430451213893	1.0	1.0	12	Q96KP1	1
Ptk6 regulates proteins involved in rna processing	0.6762901479610197	0.6551326299074358	0.5123823652282808	1.0	1.0	2	P23246	1
Rab regulation of trafficking	0.3366000895480556	0.6470044901652178	0.5176290374332326	1.0	1.0	30	Q9UL25,P31751,Q9Y3P9,Q14C86,P49815,P20339	6
Akt phosphorylates targets in the cytosol	0.5311856593249622	0.6438473763844165	0.5196744087318046	1.0	1.0	5	P31751,P49815	2
Intra golgi and retrograde golgi to er traffic	0.2935200013605341	0.6424124085636047	0.520605445035826	1.0	1.0	84	P24390,P35606,Q9Y496,P83436,O75935,Q9UJW0,O00139,P48444,Q10472,Q9Y6G9,Q9H0B6,Q14807,P53365,P20645,P68371,Q07866,O95235,Q9P2W9,Q13885,Q9UID3,P54920,O14579,Q6NUQ1,Q9NSK0,O60664,P52732,Q9H0H5,P11717,O00461,O43493	30
Separation of sister chromatids	0.2881961902494298	0.6406826662011075	0.521728878317639	1.0	1.0	94	Q9UL46,Q8NBT2,Q29RF7,Q9Y6G9,Q9UJX3,Q99436,P68371,Q06323,P28074,Q13885,Q9BZD4,P28072,Q9UJX2,Q53HL2,P60900,P49721,Q96DE5,P49720,O00231,Q2NKX8,P28070,P53350	22
Transport of bile salts and organic acids metal ions and amine compounds	0.7014440433212963	0.636746438299751	0.5242900196825429	1.0	1.0	3	P53985,Q8TAD4	2
Vxpx cargo targeting to cilium	0.4479126218111116	0.6355798452983844	0.5250503094679828	1.0	1.0	8	Q96KP1	1
Pten regulation	0.2923602506787039	0.6327856910008468	0.5268736021730185	1.0	1.0	61	P28074,Q06323,P31751,O75832,Q9Y2Q5,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q92769,P49721	16
Clec7a dectin 1 signaling	0.315667925794835	0.631503982794443	0.5277110458937506	1.0	1.0	49	P28074,O95999,O75832,O43865,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	15
Beta catenin independent wnt signaling	0.3058517158509882	0.6278718066857061	0.5300879214670005	1.0	1.0	53	P28074,O75832,P63218,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	12
Signaling by flt3 fusion proteins	0.698194945848372	0.626093590177032	0.531253556249043	1.0	1.0	3	P62993,Q14789	2
Apoptotic cleavage of cellular proteins	0.3647539182812507	0.6255850694102416	0.5315871344292893	1.0	1.0	17	P35611,P20700,P02545,P49354,P08670,Q13813	6
Class b 2 secretin family receptors	0.6922518800041505	0.6067474803181317	0.5440185070761587	1.0	1.0	3	P63218	1
Activation of ampk downstream of nmdars	0.4517925929537328	0.6045172310468552	0.545499816734945	1.0	1.0	7	P04350,P54619,Q13885,P68371	4
Degradation of beta catenin by the destruction complex	0.3163708832310793	0.600590388199468	0.5481128414570371	1.0	1.0	47	P28074,P20618,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	13
Energy dependent regulation of mtor by lkb1 ampk	0.4497746582846066	0.5954682159849575	0.5515305387965626	1.0	1.0	7	Q9Y2Q5	1
Cellular response to hypoxia	0.3240103780942403	0.5938831648522477	0.5525902597886856	1.0	1.0	40	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	12
Interleukin 1 signaling	0.3168681220490659	0.5894498562641748	0.5555595402369748	1.0	1.0	46	P28074,P20618,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Arachidonic acid metabolism	0.4272631785185358	0.5861006755988957	0.5578078623224438	1.0	1.0	9	Q8N8N7,P33527	2
Cholesterol biosynthesis	0.3582109238840918	0.5838060291582008	0.5593508214222604	1.0	1.0	17	P37268,Q16850,P14324,Q15392	4
Regulation of mrna stability by proteins that bind au rich elements	0.2883199046674123	0.5753519791941839	0.5650532740674368	1.0	1.0	63	P28074,Q01105,P28070,P28072,Q9UL46,P49720,Q92973,Q99436,O00231,P60900,P04792,Q06323,P49721	13
Flt3 signaling	0.5126218614231822	0.5720666719116315	0.5672768069938248	1.0	1.0	5	P31751,P62993	2
Constitutive signaling by overexpressed erbb2	0.6808476615155743	0.5701564136817926	0.5685716154572649	1.0	1.0	3	Q16543	1
Foxo mediated transcription of oxidative stress metabolic and neuronal genes	0.5944657458611907	0.5565861521783686	0.5778102172477064	1.0	1.0	4	Q96ST3	1
Uch proteinases	0.3161266536393706	0.5561032741296332	0.578140256982409	1.0	1.0	44	P28074,O00231,P28072,Q9UL46,P49720,Q99436,Q8NB78,P60900,P28070,Q06323,P49721	11
Downregulation of erbb2 signaling	0.4580742875594136	0.5465559886637786	0.5846838126140808	1.0	1.0	6	P31751,Q16543	2
Cell extracellular matrix interactions	0.4370414156375128	0.5390626085975434	0.5898436548401633	1.0	1.0	7	Q15404	1
Interferon gamma signaling	0.4069874362886456	0.5384596430621799	0.590259759535908	1.0	1.0	10	P10321	1
Inlb mediated entry of listeria monocytogenes into host cell	0.5018840878135744	0.5315566567891334	0.59503309099933	1.0	1.0	5	Q92783	1
Negative regulation of met activity	0.4539429842171268	0.5295021659892867	0.596457142280062	1.0	1.0	6	Q92783	1
Adrenaline noradrenaline inhibits insulin secretion	0.585963665116549	0.5279849962640649	0.5975097496201718	1.0	1.0	4	P04899	1
Arms mediated activation	0.6391194514615599	0.5254073081415573	0.5993000742298502	1.0	1.0	2	P31946	1
Rac2 gtpase cycle	0.3194120290138702	0.5152767888153098	0.6063596163112508	1.0	1.0	29	O15173,Q9H0H5,Q13505,Q86XL3,P42166	5
Deadenylation of mrna	0.3541016289850389	0.5059671881680237	0.6128796840515587	1.0	1.0	14	Q9UIV1,P23588,Q9UKZ1,Q92600	4
Pcp ce pathway	0.3064688347230853	0.5041414605219224	0.6141619736468984	1.0	1.0	47	P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	11
Thrombin signalling through proteinase activated receptors pars	0.4907894260922212	0.4905891293362219	0.6237170765305824	1.0	1.0	5	P63218	1
Thromboxane signalling through tp receptor	0.5742905602649389	0.4895026160592975	0.6244859028956267	1.0	1.0	4	P63218	1
Diseases of immune system	0.6279321544568679	0.4884615198367071	0.625222975483827	1.0	1.0	2	O15111	1
G2 m checkpoints	0.2822094345896098	0.4841221405958173	0.6282991890592182	1.0	1.0	81	P28074,Q14566,O96028,P62258,Q9UQ84,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q99640,Q06323,P49721	17
Condensation of prometaphase chromosomes	0.4055716353111362	0.4840713461531163	0.6283352359557359	1.0	1.0	9	Q15021,P14635,Q9BPX3,P67870,O95347,Q15003,P19784,P06493	8
Tnf signaling	0.4239165924143607	0.4823328194977963	0.6295695364758047	1.0	1.0	7	O95429	1
Signaling by fgfr in disease	0.3494137474666965	0.4792045327429149	0.6317931299424697	1.0	1.0	14	O95684	1
Complex i biogenesis	0.324670167866977	0.4786399055252878	0.6321948241465192	1.0	1.0	24	Q9P0J0,Q7L592,P51970,O75306,Q8TB37,Q16718,O43676,O95168,O75489	9
Alk mutants bind tkis	0.4411834209670666	0.4777358297757492	0.6328382391626959	1.0	1.0	6	O43815,P10644	2
Pyruvate metabolism	0.3604423227837676	0.4723828039354186	0.636653576269135	1.0	1.0	13	P53985,P21796	2
Cell cycle checkpoints	0.2592942628455087	0.4677400477437833	0.6399704983616141	1.0	1.0	127	Q14566,Q9UL46,P62258,Q99640,Q8NBT2,Q9UBD5,Q9Y6G9,Q9UJX3,Q99436,Q06323,P28074,Q9BZD4,P28072,Q9UJX2,Q53HL2,Q9UQ84,P60900,P49721,O96028,Q9Y619,Q96DE5,P49720,O00231,Q2NKX8,P28070,P53350	26
Tp53 regulates transcription of cell cycle genes	0.3467303115412538	0.4640342919979387	0.6426231771415192	1.0	1.0	14	Q9UIV1,Q9UKZ1,Q92600	3
Notch hlh transcription pathway	0.6390912735227834	0.4430704392813143	0.6577147859866455	1.0	1.0	3	Q92769	1
Rho gtpases activate iqgaps	0.3867868977588702	0.4419541156156882	0.6585224096376943	1.0	1.0	10	P04350,P68371,Q13885,P35221	4
Gap filling dna repair synthesis and ligation in gg ner	0.3352831241481875	0.4419151039779277	0.6585506404933896	1.0	1.0	17	P18887,P18858,P41440	3
Apc c cdc20 mediated degradation of cyclin b	0.4049913363602797	0.4405605837608762	0.6595311435427287	1.0	1.0	8	Q96DE5,Q9UJX3,Q9UJX2,Q16763,P06493	5
Regulation of lipid metabolism by pparalpha	0.3378446792524653	0.4404395537565115	0.6596187826191535	1.0	1.0	16	Q06520,P37268,Q96ST3,Q71SY5,P23786	5
Signal amplification	0.4040356499027893	0.4364166914883358	0.6625344307825385	1.0	1.0	8	P04899	1
Runx1 regulates transcription of genes involved in differentiation of hscs	0.3044144755978435	0.4322141485910036	0.6655857770794698	1.0	1.0	42	P28074,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	10
Regulation of pten localization	0.6088054853843305	0.4279106356967544	0.6687161834568778	1.0	1.0	2	P46934	1
Potential therapeutics for sars	0.308109923917279	0.4273580958156714	0.6691185239288289	1.0	1.0	30	P49356,Q15185,O75116,P21964,P49354,P07437	6
Interleukin 1 family signaling	0.2967598860999216	0.4262063009413349	0.6699575265617685	1.0	1.0	48	P28074,P20618,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	14
Chaperone mediated autophagy	0.4278491326606558	0.4252630166231135	0.6706449506169807	1.0	1.0	6	P08670	1
Gene and protein expression by jak stat signaling after interleukin 12 stimulation	0.3166702326384342	0.4239039942263096	0.6716358310776553	1.0	1.0	24	P20700,P78417,P52597,O00170,Q9UL46,Q13126	6
Tcf dependent signaling in response to wnt	0.2759438806425787	0.421289650201063	0.6735435869047977	1.0	1.0	57	P28074,P31751,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	11
E3 ubiquitin ligases ubiquitinate target proteins	0.3340109719503855	0.4181478304858552	0.6758390361117013	1.0	1.0	16	Q9BUN8,O95999,P50542,O75150,Q14527	5
Neuronal system	0.2922757214007376	0.4164704150512391	0.6770658117260309	1.0	1.0	50	P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609,P21964,O95197,P41440	11
Cell cycle mitotic	0.2853512281500024	0.4150674906763106	0.67809249713712	1.0	1.0	225	Q9Y6X3,P37198,P42166,P11802,Q14566,P30154,Q7Z3B4,Q9UL46,Q8NFH4,O75935,P62258,P07437,Q99640,O60763,Q8NBT2,Q29RF7,Q9H6D7,P52948,P31751,P02545,Q9UBD5,Q9NR33,Q9Y6G9,Q9UJX3,Q99436,O00487,Q86XL3,P68371,O95235,P41440,Q06323,P28074,Q9Y2U8,P20700,Q9BTX1,Q9BSJ2,Q13885,Q9BZD4,Q15154,P28072,P18858,P49642,Q9UJX2,Q53HL2,P60900,P49721,P20618,Q92973,Q01105,O75832,Q99567,Q14691,Q8N1F7,Q9Y619,Q96DE5,Q9BRT9,Q14181,O94927,O95684,O00231,P49720,Q2NKX8,P28070,P53350,P61981	65
Programmed cell death	0.2689317397097804	0.4101831724835216	0.6816715839748224	1.0	1.0	98	Q9UL46,Q16543,P62258,P31751,P02545,Q9NR28,P49354,Q99436,Q13813,Q06323,P41440,P28074,P35611,P20700,P28072,P08670,P60900,P49721,P49720,O75832,O00231,P28070	22
Regulation of innate immune responses to cytosolic dna	0.6267488947889999	0.4078954732132392	0.6833504163030213	1.0	1.0	3	Q9UJV9	1
Mecp2 regulates neuronal receptors and channels	0.4056117349069059	0.4060532375985564	0.6847034838996091	1.0	1.0	7	P18031,Q96ST3,Q92769	3
Cellular response to chemical stress	0.2759896093140276	0.4043591132539722	0.6859486619369599	1.0	1.0	71	P28074,P30519,P28072,P33527,Q96ST3,O00231,P28070,P49721	8
Rhog gtpase cycle	0.3052429587287575	0.4013567433604758	0.6881574920590008	1.0	1.0	33	O15173,Q9Y2U8,P02786,Q86XL3,Q86UP2,P42166,O75489	7
Constitutive signaling by akt1 e17k in cancer	0.4212325937359888	0.3999126203126771	0.6892208765634309	1.0	1.0	6	P31751	1
Glycogen breakdown glycogenolysis	0.4209043886856706	0.3986677791328916	0.6901380123108913	1.0	1.0	6	P10253	1
Inla mediated entry of listeria monocytogenes into host cells	0.5987008300252542	0.3973657389241132	0.6910977765041659	1.0	1.0	2	O60716	1
Signaling by receptor tyrosine kinases	0.2631864471350625	0.396512592848977	0.6917269198041225	1.0	1.0	104	Q9UQB8,P41240,Q96ST3,Q16543,Q9UNE7,Q92769,Q9Y487,P31751,Q01085,Q96S59,Q93050,P36543,P31943,P52597,O43865,Q9UI12,P62993,P04792,Q92783,Q8WX92,P16949,Q9Y5K8,Q14155,O75116,P09496,P20936	26
Vesicle mediated transport	0.2821290307952771	0.3951639836570084	0.6927218710336787	1.0	1.0	215	Q8WTV0,P24390,Q9Y496,O75976,O75935,Q9UIQ6,P20339,Q96A65,P31751,Q96KP1,Q9Y3P9,Q14C86,Q9H0B6,Q14108,P53365,P20645,P68371,Q07866,Q8NC96,Q9P2W9,Q9UL25,Q92783,P55327,Q9NSK0,Q6NUQ1,Q14789,Q9H0H5,Q9H3P7,Q7L5N1,P11717,O00461,P49815,Q99627,Q9NVZ3	34
Mapk6 mapk4 signaling	0.2929700361364995	0.3902058432062888	0.6963843411747408	1.0	1.0	48	P28074,P28070,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P04792,Q06323,P49721	11
Dna strand elongation	0.3024491756032214	0.3898250307095906	0.6966659333229281	1.0	1.0	29	Q14566,Q14691,P18858,P49642,P41440	5
G alpha i signalling events	0.3188072160870848	0.3890086621060428	0.6972697386601783	1.0	1.0	20	P63218,P07602,P10644,P04899	4
Reduction of cytosolic ca levels	0.6167754153727392	0.3803725602122623	0.7036688803972924	1.0	1.0	3	P16615	1
Platelet calcium homeostasis	0.6167754153727392	0.3803725602122623	0.7036688803972924	1.0	1.0	3	P16615	1
Conversion from apc c cdc20 to apc c cdh1 in late anaphase	0.4143171756387697	0.3739462610615529	0.7084442977493042	1.0	1.0	6	Q96DE5,Q9UJX3	2
Aberrant regulation of mitotic exit in cancer due to rb1 defects	0.4143171756387697	0.3739462610615529	0.7084442977493042	1.0	1.0	6	Q96DE5,Q9UJX3	2
O linked glycosylation of mucins	0.613718411552342	0.3721049807282383	0.7098146881068792	1.0	1.0	3	Q10472,O43505	2
O linked glycosylation	0.613718411552342	0.3721049807282383	0.7098146881068792	1.0	1.0	3	Q10472,O43505	2
Degradation of gli1 by the proteasome	0.2979486599735557	0.3711291334845098	0.7105413527309365	1.0	1.0	41	P28074,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721	10
Rhoh gtpase cycle	0.3279342241653228	0.3711133361547557	0.7105531183787652	1.0	1.0	15	P02786,Q9UNZ2,O75116	3
Signaling by alk in cancer	0.3010851742166066	0.3698547603328889	0.7114907108940829	1.0	1.0	33	P33176,O94979,P49589,P19174,P10644,P49792,O43815,Q9P2E9,P67936,P06753,Q8IWJ2,Q9HC35,P06748,Q14203,Q86WB0,P62993,Q07866,P12270	18
Tp53 regulates transcription of genes involved in cytochrome c release	0.5885961746661775	0.3678934026850911	0.7129527196872276	1.0	1.0	2	Q07812	1
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1	0.5846264886322546	0.3566204804362187	0.7213759431609015	1.0	1.0	2	P06493	1
Epha mediated growth cone collapse	0.4516793660010446	0.3548517470412773	0.7227006592134875	1.0	1.0	5	P60660,O75116	2
Sema4d induced cell migration and growth cone collapse	0.4516793660010446	0.3548517470412773	0.7227006592134875	1.0	1.0	5	P60660,O75116	2
Intracellular signaling by second messengers	0.272048335894076	0.3539910394978176	0.7233455984686445	1.0	1.0	79	Q9UL46,Q9UNE7,Q92769,P10644,P31751,O43815,Q9Y2Q5,Q99436,O00487,Q06323,P28074,O43865,O15111,P28072,P62993,P60900,P49721,P20618,P49720,O75832,O00231,P49815,P28070,P19174	24
Golgi associated vesicle biogenesis	0.296117982807655	0.3503852096805375	0.726049624714924	1.0	1.0	28	P55327,P02786,Q14789,P11717,Q9H3P7,O75976,O43493,Q9Y5X3,P09496,Q8NC96	10
Ripk1 mediated regulated necrosis	0.3664687346345015	0.3500610215385367	0.7262929026512464	1.0	1.0	10	P41440,O15294,Q9UNE7,Q16543	4
Formation of tubulin folding intermediates by cct tric	0.3363358095707448	0.347219973340966	0.7284260666467137	1.0	1.0	13	P78371,P04350,P49368,Q13885,P68371	5
Regulated necrosis	0.3185804376295397	0.3442881203852867	0.7306296173883471	1.0	1.0	17	P42574,Q16543,Q07812,O15294,Q9UNE7,P41440	6
Apoptosis	0.2694106269039035	0.3417014683390036	0.7325755669806489	1.0	1.0	87	Q9UL46,P62258,P31751,P02545,Q9NR28,P49354,Q99436,Q13813,Q06323,P28074,P35611,P20700,P28072,P08670,P60900,P49721,P49720,O75832,O00231,P28070	20
Interferon alpha beta signaling	0.3637364325488729	0.3381691454932917	0.7352357259012208	1.0	1.0	10	P10321	1
Neurotransmitter receptors and postsynaptic signal transmission	0.296593520191637	0.3371301505155801	0.7360187896607115	1.0	1.0	35	P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609	8
Cytosolic sulfonation of small molecules	0.4040625391711843	0.336508958939841	0.7364870968447699	1.0	1.0	6	Q06520	1
Rhobtb3 atpase cycle	0.5997954811024602	0.3354963626638275	0.7372506880675835	1.0	1.0	3	O60664	1
Neddylation	0.2690252045177809	0.3333421098201032	0.7388760561754069	1.0	1.0	67	P28074,Q9Y5A7,P61201,P20618,O75832,Q7L5N1,P28072,Q9UL46,Q9BT78,P49720,Q99436,O00231,O00487,P60900,P28070,Q99627,Q06323,P49721	18
Telomere c strand synthesis initiation	0.4426407515992336	0.3257359959626541	0.7446241074219526	1.0	1.0	5	P49642	1
Interleukin 12 signaling	0.297118859495102	0.3235464663194317	0.7462814231299277	1.0	1.0	26	P20700,P78417,P52597,O00170,Q9UL46,Q13126	6
Fceri mediated ca 2 mobilization	0.516473648851858	0.315151956988536	0.7526462809385752	1.0	1.0	4	P62993,O43865	2
Class i peroxisomal membrane protein import	0.3966364974094973	0.3102497701518183	0.756371025322389	1.0	1.0	6	Q8NBU5	1
Protein folding	0.2921521303470982	0.3082166954217136	0.7579174493521856	1.0	1.0	37	O95302,P61758,O15212,P04350,P49368,Q13885,Q9BUR4,P63218,Q9UHV9,Q99471,P68371,O75347	12
Acyl chain remodelling of pg	0.5665824612053323	0.3076596387454007	0.7583413345530252	1.0	1.0	2	Q8NF37	1
Mtor signalling	0.3139563859188365	0.3063442230006729	0.7593425715781339	1.0	1.0	16	P31751,P49815,Q9Y2Q5	3
C type lectin receptors clrs	0.2783100252930574	0.298927868313675	0.7649950829206924	1.0	1.0	51	P28074,O95999,O75832,O43865,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721	15
Trans golgi network vesicle budding	0.2913493753256401	0.2976610831418829	0.765961848841433	1.0	1.0	35	P55327,P54920,P51809,O00203,P02786,Q14789,P11717,Q92538,Q9H3P7,O75976,O43493,P20645,Q9Y5X3,P09496,Q8NC96	15
Acyl chain remodelling of pc	0.5611692529772556	0.2937276638926427	0.7689660135537326	1.0	1.0	2	Q8NF37	1
Intra golgi traffic	0.358340935336572	0.2809953923398668	0.7787139338973605	1.0	1.0	9	O00461,P83436	2
Biological oxidations	0.2860122971247161	0.2803670047300251	0.7791959487141413	1.0	1.0	43	Q06520,Q9NX62,O43169,P07099,Q16850	5
Transmission across chemical synapses	0.2869565125174669	0.2801018485671334	0.7793993665003072	1.0	1.0	41	P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609,P21964	9
Intrinsic pathway for apoptosis	0.2993422301990903	0.2795864433390079	0.779794809124903	1.0	1.0	21	P27348,P31946,P42574,P31751,Q9NR28,Q04917,P62258,Q07812,P61981	9
Dap12 signaling	0.5767301034279212	0.27885257115115	0.7803579679777051	1.0	1.0	3	P62993	1
Transcription coupled nucleotide excision repair tc ner	0.2864523391736458	0.2729597866307915	0.784884127718777	1.0	1.0	39	Q7L5N1,P18887,Q9NR33,P18858,Q9BT78,Q99627,P41440	7
Condensation of prophase chromosomes	0.3481250208357611	0.2726358191666316	0.7851331749131563	1.0	1.0	10	Q01105	1
Global genome nucleotide excision repair gg ner	0.2879012930998744	0.2722927661827497	0.7853969179159166	1.0	1.0	34	Q7L5N1,P18887,Q9NR33,P18858,Q99627,P41440	6
Golgi to er retrograde transport	0.2635628204106879	0.2716283690626124	0.7859077839534423	1.0	1.0	67	P24390,P35606,Q9Y496,O75935,Q9UJW0,O00139,P48444,Q10472,Q9Y6G9,Q9H0B6,Q14807,P68371,Q07866,O95235,Q13885,Q9P2W9,P54920,Q9NSK0,O14579,Q6NUQ1,P52732,Q9H0H5	22
Processing of smdt1	0.3476371744736253	0.2706581076578808	0.7866539997334843	1.0	1.0	10	Q96TA2,Q10713,Q9UJZ1	3
Regulation of tp53 activity through methylation	0.4176300578034737	0.2503842938484167	0.8022901745596345	1.0	1.0	5	O14744,Q96KQ7,P04637,Q9H9B1	4
Slc transporter disorders	0.2828448060699485	0.2445324246781184	0.8068184927701072	1.0	1.0	31	P35658,P57740,P37198,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,P35613,Q99567,Q9BVL2,Q8N1F7,P53985,P08195,Q8NFH4,P12270	15
Activation of nmda receptors and postsynaptic events	0.2887334766912717	0.2351646267870775	0.8140809598932917	1.0	1.0	23	P10644,Q14155,P07196,P68371,P35609	5
Caspase mediated cleavage of cytoskeletal proteins	0.3583017033775476	0.2289486700260357	0.8189088118392738	1.0	1.0	7	P08670,P35611,Q13813	3
Dna damage recognition in gg ner	0.3011836509955674	0.2278563311852543	0.8197579323758672	1.0	1.0	14	Q99627,Q7L5N1	2
Post chaperonin tubulin folding pathway	0.3358519982948756	0.2242814668387587	0.8225382962216685	1.0	1.0	10	P68371,Q13885,O75347	3
Unfolded protein response upr	0.2791617931664782	0.2169398782341761	0.8282551992308385	1.0	1.0	39	P02545,P51858,Q9NWM8,P43307	4
Transcriptional regulation by ventx	0.3167276586600681	0.2137922842792705	0.8307090421064096	1.0	1.0	12	Q96DE5,Q9UJX3	2
Diseases of mitotic cell cycle	0.3241825659813007	0.2103299772798485	0.8334101400563083	1.0	1.0	11	Q96DE5,P11802,Q9UJX3,Q9UJX2	4
Insulin receptor signalling cascade	0.4016652585105574	0.2066881846747838	0.8362533854235341	1.0	1.0	5	P31751	1
Signaling by braf and raf1 fusions	0.28756120901233	0.2060071981303498	0.8367852886094371	1.0	1.0	20	P51114,O00203,P02545,Q96PU8,Q6WCQ1,P41240,Q9NRY5	7
Interleukin 12 family signaling	0.27479129150494	0.2030553891043086	0.8390917396245419	1.0	1.0	29	P20700,P78417,P52597,O00170,Q9UL46,Q13126	6
Signaling by erbb2	0.3299837396674011	0.2022406463023901	0.8397285984419338	1.0	1.0	10	P31751,P62993,Q9UNE7,Q16543	4
Hiv infection	0.2391754636794623	0.188120177271418	0.8507824442957792	1.0	1.0	122	P18615,Q7Z3B4,O75475,Q9UL46,Q92804,P29083,P52948,Q14241,Q99436,Q8IXH7,O00487,Q06323,P28074,P43487,Q9BTX1,P28072,P18858,Q9UI12,P60900,P49721,P20618,Q8WX92,Q8N1F7,P06748,P49720,O75832,O00231,P28070,P37198	29
Formation of atp by chemiosmotic coupling	0.3243686193946541	0.1818431255173069	0.8557058394301253	1.0	1.0	10	P00846,O75947	2
Degradation of cysteine and homocysteine	0.4595360267308258	0.1772009920045669	0.8593505164882773	1.0	1.0	4	Q96SZ5	1
Slc mediated transmembrane transport	0.285802172832952	0.1724999399210117	0.8630445085883309	1.0	1.0	17	Q8TB61,Q70HW3,Q8TAD4,P53985,P08195,Q15758,P35613,Q99808	8
Aggrephagy	0.286250768649728	0.1684357103494399	0.866240516607899	1.0	1.0	16	Q13885,P61088,Q9Y6G9,P08670,P68371	5
Leishmania infection	0.2725230395659165	0.1637010995171162	0.8699664519363954	1.0	1.0	36	P10644,Q9UQB8,P04899,O43865,O15143,P63218	6
Sumoylation of rna binding proteins	0.2672917224600274	0.1573579336453973	0.874962764454096	1.0	1.0	29	P35658,P57740,P07910,P37198,P61978,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,Q99567,Q9BVL2,Q8N1F7,Q8NFH4,P12270	14
Membrane trafficking	0.2659448540959931	0.1534930765657359	0.878009449713572	1.0	1.0	209	P24390,P35606,P60520,Q9Y496,P83436,O75976,Q9Y5X3,O75935,Q9UJW0,P62258,O60763,Q9UIQ6,O00139,P20339,P48444,Q96A65,Q10472,P31751,Q96KP1,P54619,Q9Y6G9,Q9Y3P9,Q14C86,Q14807,Q14108,Q9H0B6,P53365,O95235,P20645,P68371,P61201,Q07866,Q8NC96,Q13813,Q15286,Q14247,Q9P2W9,Q13885,Q9UL25,P62993,Q9UID3,Q92783,P55327,P54920,O14579,Q6NUQ1,Q9NSK0,O60664,P02786,Q14789,P52732,Q9H0H5,Q9H3P7,Q7L5N1,P11717,O00461,Q9BT78,O43493,P49815,P09496,Q99627,P61981,Q9NVZ3	63
Irs mediated signalling	0.511828401091412	0.1494312223593291	0.8812133764247001	1.0	1.0	3	P31751	1
Dna damage reversal	0.4431252541509851	0.1448182760992656	0.8848543521015753	1.0	1.0	4	Q9H1I8,Q9C0B1	2
Apc cdc20 mediated degradation of nek2a	0.3312208982849295	0.1442384106433437	0.8853122107537159	1.0	1.0	7	Q96DE5,Q9UJX3	2
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components	0.3312208982849295	0.1442384106433437	0.8853122107537159	1.0	1.0	7	Q96DE5,Q9UJX3	2
Pi3k akt signaling in cancer	0.2988051743087995	0.144186558010898	0.8853531551816365	1.0	1.0	12	P31751,P49815,P62993,O43815	4
Signaling by wnt in cancer	0.3279103398409144	0.1348544686015984	0.8927269394049975	1.0	1.0	7	P30153,Q13363,P30154,P56545,P48729,P35222	6
Glycogen metabolism	0.3155435831467261	0.1296832261743125	0.8968170540614331	1.0	1.0	9	P46976,P10253	2
Ns1 mediated effects on host pathways	0.2643578545721152	0.1223053799656089	0.902657171392134	1.0	1.0	32	P35658,P57740,P37198,O00505,P52294,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,Q86U42,Q99567,Q9BVL2,Q14974,Q8N1F7,Q8NFH4,P12270	16
Inflammasomes	0.4935018050541458	0.1214155309629497	0.9033619159570904	1.0	1.0	3	Q9Y2Z0,P09601	2
Purinergic signaling in leishmaniasis infection	0.4935018050541458	0.1214155309629497	0.9033619159570904	1.0	1.0	3	Q9Y2Z0,P09601	2
The nlrp3 inflammasome	0.4935018050541458	0.1214155309629497	0.9033619159570904	1.0	1.0	3	Q9Y2Z0,P09601	2
Translation of replicase and assembly of the replication transcription complex	0.4731143991338798	0.1208391227686776	0.9038184616547272	1.0	1.0	2	O43633	1
Amino acids regulate mtorc1	0.291582097166025	0.1185549455083305	0.905627961794881	1.0	1.0	12	Q9Y5K8,Q9Y2Q5,Q9UI12,Q8NFG4,P36543	5
Host interactions of hiv factors	0.248608621414884	0.1097517123176244	0.9126062875943116	1.0	1.0	92	Q7Z3B4,O75475,Q9UL46,P52948,Q99436,O00487,Q06323,P28074,P43487,Q9BTX1,P28072,Q9UI12,P60900,P49721,P20618,Q8N1F7,P06748,P49720,O75832,O00231,P28070,P37198	22
Formation of tc ner pre incision complex	0.2665938905180876	0.1092916206964325	0.9129711924999272	1.0	1.0	22	Q99627,Q9BT78,Q7L5N1	3
Rhod gtpase cycle	0.2623292228694767	0.1073074206712932	0.914545097692977	1.0	1.0	25	O15173,Q9H0H5,P20700,P12814	4
Basigin interactions	0.3569154048209114	0.1047674270642902	0.9165603572066924	1.0	1.0	5	P53985,P08195	2
Interleukin 23 signaling	0.4601226993864932	0.1040613460284261	0.917120665668834	1.0	1.0	2	P07237	1
Rhobtb2 gtpase cycle	0.267687215766099	0.1025491578993269	0.918320796119262	1.0	1.0	19	P62995,P78371,Q9NYL9,P12814,Q12792,Q16543	6
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain	0.4561530133525683	0.0993611933202829	0.9208514934881112	1.0	1.0	2	P04637	1
Interactions of vpr with host cellular proteins	0.2610862243356482	0.0983033569972011	0.9216914125969906	1.0	1.0	33	Q9BTX1,Q7Z3B4,P52948,Q99567,O75475,Q8N1F7,P37198	7
Dissolution of fibrin clot	0.4760296217846083	0.098217811049924	0.9217593396719412	1.0	1.0	3	P60903	1
Cristae formation	0.2642751242152404	0.0900333445096514	0.9282607173326124	1.0	1.0	20	Q13505,Q9NX63,P56385,O75947,P00846	5
Lipophagy	0.4664392856621071	0.0869081439373098	0.9307445260906106	1.0	1.0	3	O60664	1
Synthesis of bile acids and bile salts	0.3972553268327892	0.0728869707198109	0.9418960622243792	1.0	1.0	4	P51659,P22059,Q96SU4	3
Bile acid and bile salt metabolism	0.3972553268327892	0.0728869707198109	0.9418960622243792	1.0	1.0	4	P51659,P22059,Q96SU4	3
Pyroptosis	0.3033261026753301	0.0722754212636775	0.942382724520518	1.0	1.0	7	P09429,O43633,P04637,Q8WUX9,Q07812,P42574	6
Glycogen synthesis	0.3378828711358288	0.0711462157384961	0.9432813864959432	1.0	1.0	5	P46976	1
Noncanonical activation of notch3	0.4103211836881894	0.0583071743747254	0.9535039529150542	1.0	1.0	2	Q92542	1
Beta catenin phosphorylation cascade	0.3276734104046344	0.0555194136097146	0.9557246639785412	1.0	1.0	5	P35222,P30153,P30154,P48729	4
Disassembly of the destruction complex and recruitment of axin to the membrane	0.3276734104046344	0.0555194136097146	0.9557246639785412	1.0	1.0	5	P35222,P30153,P30154,P48729	4
Signaling by ctnnb1 phospho site mutants	0.3276734104046344	0.0555194136097146	0.9557246639785412	1.0	1.0	5	P35222,P30153,P30154,P48729	4
Enos activation	0.38136511375948	0.0542239905747883	0.9567567070844748	1.0	1.0	4	P31749,O75608,P07900	3
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation	0.381365113759478	0.0542239905747866	0.9567567070844762	1.0	1.0	4	P00374,P31749,P07900	3
Zbp1 dai mediated induction of type i ifns	0.4315029347081104	0.053743926958151	0.9571391847013802	1.0	1.0	3	O15111	1
Rip mediated nfkb activation via zbp1	0.4315029347081104	0.053743926958151	0.9571391847013802	1.0	1.0	3	O15111	1
Cd28 co stimulation	0.2948653345518491	0.0537146633120696	0.9571625000346952	1.0	1.0	7	P31751	1
Regulation of tp53 expression and degradation	0.2709547041558267	0.0536279703541266	0.9572315714517527	1.0	1.0	12	P31751,P30154,P06493	3
Flt3 signaling in disease	0.3737002934803192	0.0463089620675939	0.9630639962773024	1.0	1.0	4	Q14789	1
Repression of wnt target genes	0.4212996389891635	0.0462610475224556	0.9631021856246348	1.0	1.0	3	Q13547,P56545	2
Gab1 signalosome	0.3722400359900827	0.0448786809214866	0.9642040098801212	1.0	1.0	4	P62993	1
Lysosome vesicle biogenesis	0.2613455688774162	0.0442469255742834	0.9647075774579954	1.0	1.0	13	P15586,P51809,Q10567,P20645,P09496	5
Cohesin loading onto chromatin	0.2886805269612727	0.044097174243388	0.9648269452225412	1.0	1.0	8	Q9Y6X3	1
Map2k and mapk activation	0.2729753009319262	0.0438222487131075	0.9650460922095224	1.0	1.0	11	Q9Y2Q5	1
Hsf1 activation	0.2538597115494149	0.0400561562075341	0.9680483560042624	1.0	1.0	15	O75190,P62258,P04792	3
P130cas linkage to mapk signaling for integrins	0.3720678455431153	0.0394495136397843	0.9685320044326924	1.0	1.0	2	P46108	1
Notch3 activation and transmission of signal to the nucleus	0.4104693140794152	0.0393006449246101	0.9686506924395788	1.0	1.0	3	Q92542,Q9Y6A5	2
Trafficking and processing of endosomal tlr	0.3680981595091955	0.038107353669613	0.9696020881899352	1.0	1.0	2	P07858	1
Defects in cobalamin b12 metabolism	0.3478888487910421	0.0326697226576505	0.9739379688159931	1.0	1.0	2	Q96EY8	1
Response of eif2ak1 hri to heme deficiency	0.3981949458483698	0.0325449303287832	0.9740374857692832	1.0	1.0	3	P08243,P20042	2
Vitamin b5 pantothenate metabolism	0.3560852293246615	0.0306473512155953	0.9755507790585736	1.0	1.0	4	Q9NRN7,Q13057,Q9NVE7	3
Pp2a mediated dephosphorylation of key metabolic factors	0.3912141432773387	0.0291992181354727	0.9767057048065886	1.0	1.0	3	P30154	1
Ncam signaling for neurite out growth	0.2849794104240208	0.0265853190953123	0.9787904827868286	1.0	1.0	6	Q13813	1
Ticam1 rip1 mediated ikk complex recruitment	0.3748849875035659	0.0226394147881458	0.9819379034219397	1.0	1.0	3	O15111	1
Irak1 recruits ikk complex	0.3748849875035659	0.0226394147881458	0.9819379034219397	1.0	1.0	3	O15111	1
Ikk complex recruitment mediated by rip1	0.3748849875035659	0.0226394147881458	0.9819379034219397	1.0	1.0	3	O15111	1
Mhc class ii antigen presentation	0.2451353713175414	0.0222882550697642	0.9822180176530912	1.0	1.0	52	P33176,Q9Y496,O75935,Q9UJW0,O00139,P47756,Q9Y6G9,Q9H0B6,Q14807,P68371,Q07866,P10619,O95235,P04350,Q13885,Q9NSK0,P52732,Q9H0H5,P09496	19
Sialic acid metabolism	0.2974415682353533	0.0186895057612317	0.9850887999835902	1.0	1.0	5	P16278,Q9NR45,P10619	3
Signaling by notch1 pest domain mutants in cancer	0.2785716209908634	0.0173864956558492	0.9861282824340376	1.0	1.0	6	Q92542,Q92769	2
Attenuation phase	0.2567091075203146	0.0162401673771185	0.9870427907497314	1.0	1.0	12	O75190,P04792	2
Signaling by notch3	0.2893786127167663	0.0111021836653916	0.991141921034788	1.0	1.0	5	Q13573,P67809,Q92542,Q9Y6A5	4
Response of mtb to phagocytosis	0.2537371724171504	0.0092191582074493	0.992644280200124	1.0	1.0	12	P23246,P20339	2
Infection with mycobacterium tuberculosis	0.2537371724171504	0.0092191582074493	0.992644280200124	1.0	1.0	12	P23246,P20339	2
Interaction between l1 and ankyrins	0.3174052445800432	0.0071250754736062	0.9943150603860328	1.0	1.0	4	Q13813,Q01082	2
Methylation	0.2693640047316032	0.0070676764594683	0.994360857020072	1.0	1.0	7	P21964,P78417	2
Generation of second messenger molecules	0.2552346570397041	0.0066921624697341	0.994660466742245	1.0	1.0	3	P16333,P19174	2
Met activates ras signaling	0.3146185915024103	0.005923989801131	0.9952733676451412	1.0	1.0	4	P62993	1
Mitotic spindle checkpoint	0.2477396513560285	0.0002546628684204	0.9997968084312738	1.0	1.0	45	Q8NBT2,O00139,P30154,P52948,Q9BZD4,Q9Y6G9,Q9UJX3,Q9UJX2,Q96DE5,Q8NFH4,Q53HL2,Q16763,Q2NKX8,P53350	14
Resolution of abasic sites ap sites	0.2397340948704494	7.136799001519871e-05	0.9999430565826796	1.0	1.0	24	P18887,P18858,P41440	3