Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Mitochondrial protein import 0.7415173932122318 3.6660050550561536 0.0002463690566252 0.2845594690576513 0.0090095796431423 35 Q13505,O60830,Q99595,Q9Y5L4,Q9Y584,Q9NS69 6 Protein localization 0.524904272105078 2.8418745681614306 0.0044849133053612 0.9977765738295123 0.0734337009877827 67 Q13505,O60830,O14925,Q9Y276,Q99595,P51648,O15254,P09601,Q9Y5L4,P46379,Q9Y584,Q9NS69 12 Cristae formation 0.7415467089328313 2.8253763661095515 0.0047225108874584 0.998392531117357 0.0754877015536876 20 Q13505 1 Endogenous sterols 0.987364620938628 2.652257680251026 0.0079955496393842 0.999981718565763 0.1025089807539918 2 Q16850 1 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5277811782748836 2.6237944614910385 0.0086956242940525 0.9999929960260052 0.1084160863818114 58 Q12931,Q9BQ95,P14927,P00846,O75947,P51970,Q86Y39,Q9NX14,O14949,P13073,Q9UDW1,O75489,P15954,Q16795,P56385,Q16718,P06576,O75306,Q7L592,P09669,Q8TB37,P36542,O43676,O75251 24 Cargo trafficking to the periciliary membrane 0.6947744583631659 2.5623199692167944 0.0103975477868452 0.9999993220828236 0.1239497144063389 20 A6NIH7,Q96A65 2 Organelle biogenesis and maintenance 0.4533703756431677 2.5250282097939656 0.0115689002303229 0.9999998644312408 0.1367142209826863 83 Q13505,A6NIH7,Q96A65,P00846 4 Respiratory electron transport 0.5312819373425998 2.4583182142291764 0.0139589426324537 0.9999999949498616 0.1493716774606669 48 P13073,O75306,Q7L592,P09669,P51970,Q9UDW1,Q8TB37,Q9BQ95,O75489,P15954,P14927,Q86Y39,O43676,Q16795,O75251,Q16718,Q9NX14,O14949 18 Downregulation of erbb2 erbb3 signaling 0.9259927797833928 2.3878488487723786 0.0169473102687207 0.9999999999183672 0.1718760795163545 2 P31749 1 Akt phosphorylates targets in the nucleus 0.9259927797833928 2.3878488487723786 0.0169473102687207 0.9999999999183672 0.1718760795163545 2 P31749 1 Regulation of gene expression in beta cells 0.9259927797833928 2.3878488487723786 0.0169473102687207 0.9999999999183672 0.1718760795163545 2 P31749 1 Complex i biogenesis 0.618886506487301 2.265350342075129 0.0234911890490443 0.9999999999999908 0.2274540023194522 24 O75306,Q7L592,P51970,Q8TB37,O75489,Q9BQ95,O43676,Q86Y39,Q16795,Q16718,Q9NX14 11 Cellular response to starvation 0.4228683273122679 2.2642499556209703 0.0235587456458414 0.9999999999999916 0.2274540023194522 88 P36543,P62906,P47914,P18077,Q6IAA8,P42345,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P21281,P35268,P62244,P62829,P62269,P39019,P62750,P61247,P08865,P62277,P05388,P46781,P46779,P61353,P42766,P21283,P18124,P26373,P05387,P61254,Q9Y2Q5 42 Metabolism of vitamins and cofactors 0.5169234651141908 2.2485264667245906 0.024542639375634 0.999999999999998 0.2332408874929138 40 Q13057,O00764,Q6NUM9,P31749,P00374,Q9H2D1,P09455,Q9BQG2,Q9HCC0,P33527,P43490 11 Processive synthesis on the c strand of the telomere 0.8295574178086986 2.2273157266401262 0.0259261801974348 0.9999999999999996 0.242941579343222 9 P18858 1 Mitochondrial biogenesis 0.5689927095282601 2.2042564185960187 0.0275063160288069 1.0 0.2487455706655008 31 Q13505,Q04837,P00846,Q5XKP0,P56385,P04179,P54619 7 Processive synthesis on the lagging strand 0.7371741022728553 2.1763719654952287 0.0295274583055595 1.0 0.2597927487950964 12 P18858 1 Piwi interacting rna pirna biogenesis 0.8571795028783641 2.1113262702494975 0.0347442775332309 1.0 0.2879114217540296 7 P19388 1 Sphingolipid de novo biosynthesis 0.7708600635385884 2.0846862439769556 0.0370977901282079 1.0 0.3055292714706707 10 P51648,Q9Y5P4,Q06136,O95470 4 Cdc42 gtpase cycle 0.5801926525487471 2.0484239043686685 0.0405184812565084 1.0 0.3220152984069884 25 Q9UQB8,P14923,Q9NSV4,P52565,Q9H0H5,Q6IAA8,O00161 7 Response of eif2ak4 gcn2 to amino acid deficiency 0.4274195419211447 2.0128546898602635 0.0441299184633625 1.0 0.3367424638041695 76 P62906,P47914,P18077,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P35268,P62829,P62244,P62269,P39019,P62750,P61247,P08865,P62277,P05388,P46781,P61353,P42766,P18124,P26373,P05387 34 Ticam1 traf6 dependent induction of tak1 complex 0.8361010830324898 1.9884753709675584 0.0467591402611531 1.0 0.3367424638041695 2 O43318 1 Irak2 mediated activation of tak1 complex 0.8361010830324898 1.9884753709675584 0.0467591402611531 1.0 0.3367424638041695 2 O43318 1 Traf6 mediated induction of tak1 complex within tlr4 complex 0.8361010830324898 1.9884753709675584 0.0467591402611531 1.0 0.3367424638041695 2 O43318 1 Alpha protein kinase 1 signaling pathway 0.8361010830324898 1.9884753709675584 0.0467591402611531 1.0 0.3367424638041695 2 O43318 1 Activation of ppargc1a pgc 1alpha by phosphorylation 0.8357400722021646 1.9868444966774952 0.0469396319068338 1.0 0.3367424638041695 2 P54619 1 Transcription coupled nucleotide excision repair tc ner 0.4853721633737455 1.9746239550602491 0.0483108384981347 1.0 0.3437404686856815 39 P18858,P35244,P19388 3 Regulation of localization of foxo transcription factors 0.8216022746711854 1.9668680393281632 0.0491984260213178 1.0 0.34420619730579 7 Q9Y3B8,P31749 2 Downregulation of erbb2 signaling 0.8434360170856281 1.9434035574372812 0.0519674177866091 1.0 0.3496223800594152 6 Q9UNE7,P31749 2 Translation of replicase and assembly of the replication transcription complex 0.825631768953067 1.9410999128675095 0.0522461596415309 1.0 0.3497661623292635 2 Q8WUX9 1 Eukaryotic translation elongation 0.4182994063440802 1.9331646479841895 0.0532159182148872 1.0 0.3545119257550577 77 P62906,P47914,P18077,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P35268,P62244,P62829,P62269,P39019,P62750,P61247,P08865,P62277,P05388,P46781,P61353,P42766,P18124,P26373,P05387 34 Mastl facilitates mitotic progression 0.8554978285831301 1.907321974071891 0.0564789063767836 1.0 0.3691179336532484 5 P14635 1 Rac2 gtpase cycle 0.5375089592313456 1.896112341770024 0.0579451909612782 1.0 0.3691179336532484 29 Q13505,O15173,Q9NSV4,P52565,Q9H0H5 5 Translocation of slc2a4 glut4 to the plasma membrane 0.5053307391777592 1.88002897944653 0.0601041285043255 1.0 0.378155141839715 34 P68371,Q96KP1,Q04917,P31749,P31751,Q8TAG9,O00161,Q9Y3B8,Q96A65,P54619 10 Selenoamino acid metabolism 0.3918444001275844 1.870785221830082 0.061374856783098 1.0 0.3791553279851082 89 P62906,P47914,P18077,P62249,P62910,Q9Y3U8,P62899,P62753,Q16881,P62424,P62841,P49591,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P35268,P62244,P62829,P62269,P39019,P62750,P61247,P08865,P62277,P05388,P46781,P61353,P42766,P18124,P26373,P05387 36 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.7211536335346191 1.8581605019431329 0.0631462251797043 1.0 0.3825267894009247 10 P14635 1 Insulin processing 0.7681754359237514 1.8581412923384484 0.0631489523285022 1.0 0.3825267894009247 8 Q96KP1,Q8TAD4,Q96A65 3 Synthesis of ip2 ip and ins in the cytosol 0.8072202166064963 1.857397175397429 0.063254668052457 1.0 0.3825267894009247 2 Q01968 1 Activation of bad and translocation to mitochondria 0.7401062736915996 1.8369286745048108 0.0662204255468339 1.0 0.3852405848443819 9 Q9Y3B8,P31751,P31749 3 Signaling by vegf 0.5386746818516325 1.8364666242063816 0.0662886738995065 1.0 0.3852405848443819 27 Q9UQB8,P20936,P31749,P31751,P04792 5 B wich complex positively regulates rrna expression 0.5962127419906068 1.8236434034081197 0.0682060003029074 1.0 0.3918526719854641 17 O15160,O60264,P19388,Q9H9Y6,O95602,P62805,P35659 7 Transcriptional regulation of granulopoiesis 0.7598089165854112 1.8222467987883184 0.0684175465662231 1.0 0.3918526719854641 8 P40763,Q03164,P35659,Q13951 4 Rho gtpase cycle 0.3666236629188715 1.7814687789195471 0.0748359009046597 1.0 0.4070687118807687 136 Q13505,Q9UQB8,O95202,Q8NBN3,Q02952,P52565,O43396,Q5JTV8,Q92783,Q9NQW6,Q96KM6,Q96HY6,Q96JJ3,Q01968,O75489,Q9BX68,Q9H0H5,O15173,P51648,P14923,P30519,Q9NSV4,P80723,O00161,P15924 25 Cytochrome p450 arranged by substrate type 0.9730757033770168 1.781177897610137 0.0748833932026262 1.0 0.4070687118807687 3 Q16850 1 Heme degradation 0.8230599056860012 1.7811749842075868 0.0748838689994055 1.0 0.4070687118807687 5 P30519,P33527 2 Eukaryotic translation initiation 0.3852139584629524 1.769604545804219 0.0767930410647466 1.0 0.4126270345763446 100 P62906,P47914,P08708,P18077,P11940,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P35268,P62244,P62829,P62269,P39019,P62750,Q04637,P61247,Q7L2H7,P08865,O60841,P62277,P05388,P61254,P46781,P46779,P61353,P42766,P18124,P26373,Q14152,P05387,O75822,O00303 44 Mtor signalling 0.5940919325450328 1.7676413939630908 0.0771208732762263 1.0 0.4126270345763446 16 P31749,Q9Y376,P31751,Q6IAA8,Q96B36,P62753,P54619 7 Telomere maintenance 0.476340219563207 1.7613787127716172 0.0781743255343059 1.0 0.4134899883165319 36 P18858,P19388 2 Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.7002013934190484 1.7612568335209642 0.0781949426029056 1.0 0.4134899883165319 10 Q03164,Q13951 2 Srp dependent cotranslational protein targeting to membrane 0.3825118716607414 1.7480755591929011 0.0804509445064716 1.0 0.4188997455336969 90 P62906,P47914,P67812,P18077,P08240,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P43307,P30050,P62861,P04844,P62241,P04843,P35268,P62244,P62829,P62269,P39019,P62750,P61247,P08865,P62277,P05388,P46781,P61353,P42766,P18124,P26373,P05387 39 Resolution of abasic sites ap sites 0.5371827350097249 1.736730079694477 0.0824348257633758 1.0 0.4206601603968952 24 P18858,P13051,P35244,Q07864 4 Polb dependent long patch base excision repair 0.7910739330766087 1.7342107381392151 0.0828806983665328 1.0 0.4206601603968952 6 P18858 1 Esr mediated signaling 0.4562336662521122 1.7270106134563117 0.0841657573824354 1.0 0.4236343121582586 40 P19388,P31749,P31751,Q13951,P04792,P04899 6 Cdc6 association with the orc origin complex 0.7768953068592037 1.7185621306171248 0.085694132166131 1.0 0.4297355188700079 2 Q9UBD5 1 Metabolism of water soluble vitamins and cofactors 0.4890100857678916 1.7025472156660637 0.0886528353441238 1.0 0.441315762757012 33 Q13057,O00764,P00374,Q9H2D1,Q9HCC0,P33527,P43490 7 Chromosome maintenance 0.4535221954217474 1.69949316696865 0.0892263009535767 1.0 0.4425494269923752 39 P18858,P19388 2 Inhibition of dna recombination at telomere 0.6853949839074779 1.6923156954845917 0.0905857967791057 1.0 0.4460365863145096 10 Q9UER7,P19388,P46100 3 Positive epigenetic regulation of rrna expression 0.5201756624646077 1.6771066452842305 0.0935216295738878 1.0 0.4501591301736863 26 O15160,O60264,P19388,P62805,Q9H9Y6,O95602,P16104,Q86YP4,P35659 9 Nonsense mediated decay nmd 0.3780437606773358 1.6741634972158583 0.0940984712935297 1.0 0.4501591301736863 85 P62906,P47914,P18077,P11940,P62249,P62910,Q9Y3U8,P62899,P62753,P62424,P62841,P32969,P63173,P62263,P62081,P15880,P30050,P62861,P62241,P35268,P62244,P62829,P62269,P39019,P62750,Q04637,P61247,P08865,P62277,P05388,P46781,P61353,P42766,P18124,P26373,P05387 36 Peptide hormone metabolism 0.6353996227625045 1.6723687906288272 0.0944516223618623 1.0 0.4501591301736863 12 Q96KP1,Q8TAD4,Q96A65,Q8TAG9 4 Activation of bh3 only proteins 0.6581800344827233 1.6709301495902196 0.0947354755185241 1.0 0.4501591301736863 11 Q9Y3B8,P31751,P31749 3 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.723680924081791 1.666018829711536 0.0957096640781096 1.0 0.4532036009831046 8 P14635 1 Rna polymerase i transcription 0.5350442515533519 1.6605784529647056 0.0967981394265979 1.0 0.4551857144662514 21 O15160,P19388,P62805,O95602,Q9H9Y6,P16104,Q86YP4,P18074 8 Nucleotide excision repair 0.4440370700062679 1.6555959425453015 0.0978036724207696 1.0 0.4583282442062961 46 P18858,P35244,P19388,Q07864 4 Vxpx cargo targeting to cilium 0.7182998554773714 1.6425909183822294 0.1004676010205838 1.0 0.4671677728396965 8 Q96KP1,Q96A65 2 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.4373423872756136 1.6326746792542712 0.1025374355682844 1.0 0.4681441004668777 50 P62841,P62244,P62269,P39019,P62263,P62081,P15880,Q04637,P61247,Q7L2H7,Q14152,P11940,P62861,O75822,O00303,P62249,P62241,P62753 18 Estrogen dependent nuclear events downstream of esr membrane signaling 0.7846464387150832 1.6301125364953737 0.103077714611323 1.0 0.4681441004668777 5 P31749 1 Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.5381274389962581 1.6246231324183489 0.1042428850612411 1.0 0.4706514312233445 20 P18858,P35244,Q07864 3 Runx2 regulates genes involved in cell migration 0.9263271939328248 1.6105468324738066 0.1072785300959793 1.0 0.4764428836615552 3 Q13951,P31749 2 Activated tak1 mediates p38 mapk activation 0.7741181798390193 1.5884297392554358 0.1121891970998767 1.0 0.4893370984220493 5 O43318,P61088,Q15750 3 Rac3 gtpase cycle 0.4942937315197211 1.586338327360804 0.1126625823571076 1.0 0.4893370984220493 29 Q9UQB8,Q01968,O15173,Q9NSV4,Q9H0H5,Q6IAA8,O00161 7 Formation of incision complex in gg ner 0.63715769198344 1.5684056460095446 0.1167864943100776 1.0 0.4984803878426289 11 P18074,P35244,Q9UGN5,P61088 4 Metabolism of porphyrins 0.6801417730850197 1.5674522916526032 0.1170090093611468 1.0 0.4984803878426289 9 P30519,P33527 2 Cell death signalling via nrage nrif and nade 0.6576718789800711 1.5623135812562732 0.1182141341145852 1.0 0.4995370092488459 10 P42575,Q9NY61,Q14155,Q92542,Q92974,P42574 6 Inlb mediated entry of listeria monocytogenes into host cell 0.7608377395699093 1.5357014095556307 0.1246116292176191 1.0 0.5074579206468633 5 Q9NWH9 1 Rna polymerase i promoter escape 0.6077873514740195 1.5319867577518196 0.1255257025624712 1.0 0.5074579206468633 12 O15160,P19388,P62805,O95602,Q9H9Y6,P18074 6 Pcna dependent long patch base excision repair 0.5447569827642511 1.524726382424273 0.1273273584945631 1.0 0.5074579206468633 17 P18858,P35244 2 Mecp2 regulates transcription of neuronal ligands 0.9014675955779772 1.5192580383354264 0.1286975574989686 1.0 0.5074579206468633 3 Q96ST3 1 Leishmania infection 0.4470100080378005 1.5182958864213705 0.1289398242315791 1.0 0.5074579206468633 36 Q9UQB8,P09601,P63218,P04899,Q9Y3E5 5 Transcriptional regulation by runx2 0.4223265392565793 1.5138259952514013 0.1300699776609399 1.0 0.5074579206468633 52 P55036,O00487,P31749,P49721,P31751,Q13951,Q9UNE7,P14635 8 Visual phototransduction 0.7366542954676678 1.5131793868001069 0.1302340987342818 1.0 0.5074579206468633 6 P09455 1 Apoptosis induced dna fragmentation 0.6459107840327171 1.506847197093714 0.1318498286530554 1.0 0.5104954904259325 10 P42574,P07305,P10412,P16403 4 Base excision repair 0.4905044049285053 1.501148629866644 0.133317123217308 1.0 0.5110190931787362 27 P18858,P13051,P35244,Q07864 4 Gap filling dna repair synthesis and ligation in gg ner 0.540700966286465 1.5009244790418426 0.1333750959301358 1.0 0.5110190931787362 17 P18858,P35244 2 Mecp2 regulates neuronal receptors and channels 0.7097619261779783 1.500483644257714 0.1334891670923115 1.0 0.5110190931787362 7 Q96ST3,P51608,Q9NWH9 3 Runx1 regulates transcription of genes involved in differentiation of hscs 0.4286476681992524 1.4915194198684958 0.1358251764911142 1.0 0.5121484280582168 42 P55036,O75832,O00487,Q03164,P62805,P49721,P28072,Q13951,Q14997 9 Amino acid transport across the plasma membrane 0.7270758122743652 1.4884941799201168 0.1366206158938911 1.0 0.5121484280582168 2 P08195 1 Formation of atp by chemiosmotic coupling 0.6412682695081562 1.484908461485246 0.137568074283906 1.0 0.5121484280582168 10 P00846 1 Extra nuclear estrogen signaling 0.5484941201819398 1.479137515367467 0.139103565403349 1.0 0.5121484280582168 15 P04792,P04899,P31751,P31749 4 Rna polymerase i transcription initiation 0.5360741824095676 1.473739869868406 0.1405516436248961 1.0 0.5148508994238109 17 O15160,P19388,Q9H9Y6,O95602,Q86YP4,P18074 6 Formation of senescence associated heterochromatin foci sahf 0.695614169584994 1.4404506446965988 0.1497399440658053 1.0 0.5355173262774461 7 P07305,P17096,P16403 3 Hsf1 activation 0.5388572535712386 1.424436647474412 0.1543201119507335 1.0 0.5355993156117654 15 P04792,P35244 2 Signaling by hippo 0.7149819474553841 1.4243777872196566 0.1543371407631601 1.0 0.5355993156117654 6 Q4VCS5,Q13043,P42574 3 Rac1 gtpase cycle 0.4532791246319823 1.4238419692500874 0.1544922234877204 1.0 0.5355993156117654 33 Q9UQB8,Q9NSV4,P52565,Q9H0H5,Q6IAA8,O00161 6 The citric acid tca cycle and respiratory electron transport 0.3563561796130278 1.4190526068892395 0.1558836795282643 1.0 0.5390481437122423 88 Q12931,Q9BQ95,P14927,Q15120,Q96I99,P00846,O75947,P51970,Q86Y39,Q9NX14,O14949,P13073,Q9UDW1,O75489,P15954,Q16795,P56385,Q16718,P06576,P11177,P07954,Q7L592,Q04760,P09669,Q8TB37,P36542,O75306,P23368,O43676,O75251 30 Signaling by nuclear receptors 0.4101926932416485 1.4094143254165952 0.1587126905607476 1.0 0.546052016384952 53 P19388,P62805,P31749,P31751,Q13951,P04792,Q01469,P63218,P04899,O00767 10 Abc family proteins mediated transport 0.4112560497545308 1.4079459864043091 0.1591470645816466 1.0 0.5461637898142873 52 P55036,O75832,O00487,O75027,P49721,P28072,Q9BUN8,P33527,Q8NE71,O15439,Q9NRK6 11 Regulation of tp53 activity through association with co factors 0.8675401124222328 1.3943001841564022 0.1632269753456912 1.0 0.5531806969944996 3 P31749 1 Negative regulation of nmda receptor mediated neuronal transmission 0.723812685568254 1.3879857011746368 0.1651413992396717 1.0 0.5582765213102335 5 P49593,P07196 2 Dual incision in tc ner 0.464989819306329 1.3734416629578328 0.1696150851839739 1.0 0.5653446372772049 29 P35244,P19388 2 Regulation of tp53 activity through acetylation 0.6176078609508551 1.37278203001849 0.1698201188355557 1.0 0.5653446372772049 10 P31751,P31749 2 G beta gamma signalling through pi3kgamma 0.7161214945030938 1.3572040352429136 0.174716388944339 1.0 0.572607105360081 5 P31751,P31749 2 Transport of small molecules 0.3410084889188426 1.3567585367424086 0.1748579460812609 1.0 0.572607105360081 134 O95202,O75832,P33527,Q8WTV0,P63218,Q8TAD4,O75027,P49721,Q8N4V1,Q8NE86,Q96TA2,Q9UBX3,P55036,P21281,O00487,P28072,Q70HW3,Q9BUN8,Q8NE71,O15439,O94973,Q8TB61,Q9C0H2,P30519,P09601 25 Phase i functionalization of compounds 0.5517869715291118 1.3520168421082674 0.1763699275354509 1.0 0.5747883249896348 13 Q16850,P22570 2 Mismatch repair 0.5897910145463142 1.3353596848742757 0.181758652884949 1.0 0.5873583734390855 11 P18858 1 Signaling by rho gtpases miro gtpases and rhobtb3 0.3229016624955106 1.3341930253396166 0.1821406047443858 1.0 0.5873583734390855 222 Q13505,Q9UQB8,P04350,O95202,P68371,Q8NBN3,P84095,Q02952,P52565,Q6IAA8,O43396,Q5JTV8,Q92783,Q53HL2,P62805,Q12792,Q99661,Q9NQW6,O43237,Q9BZD4,Q96KM6,Q2NKX8,Q96HY6,O15498,Q9HBM1,Q96JJ3,Q01968,Q04917,P50748,O75489,Q16539,Q9BX68,Q9H0H5,O95140,O43663,O75116,O15173,P51648,P14923,P30519,Q9NSV4,Q9P2R3,P80723,O00161,O00139,Q9Y3B8,Q86XL3,P15924 48 Class b 2 secretin family receptors 0.8511807388068228 1.3339875450976828 0.182207938392735 1.0 0.5873583734390855 3 Q9Y3E5 1 Hiv elongation arrest and recovery 0.5181358510385934 1.3323642088595458 0.182740537229892 1.0 0.5873583734390855 16 P19388 1 G protein beta gamma signalling 0.6900722253611744 1.32196829391683 0.1861787090465525 1.0 0.5925453526797774 6 P31751,P31749 2 Cd28 dependent pi3k akt signaling 0.8467128596203028 1.317517878368148 0.1876650923056551 1.0 0.5944915161850473 3 P31749 1 Cellular response to chemical stress 0.3742752570646525 1.3139779293517924 0.1888536316134996 1.0 0.5968653147970838 71 P55036,O75832,P13073,P09669,O00487,P49721,Q96ST3,P28072,P30519,P09601,P33527,P40763,P04179,Q16881,Q14997 15 Negative epigenetic regulation of rrna expression 0.4809015944048838 1.3124005822556786 0.1893850105386429 1.0 0.5971559845058372 21 O15160,O60264,P19388,P62805,Q9H9Y6,O95602,Q96ST3,Q9UHR5,P18074 9 Rna polymerase i transcription termination 0.623645523486566 1.3096465203331351 0.1903154431598825 1.0 0.5987006649404639 9 O15160,P18074,P19388,Q9H9Y6 4 Lagging strand synthesis 0.4987729097459878 1.290853203448287 0.1967545850275631 1.0 0.6119915960994512 18 P18858 1 Negative regulation of met activity 0.6821730253516172 1.289448168810481 0.197242324570684 1.0 0.6119915960994512 6 Q9NWH9 1 Negative regulation of the pi3k akt network 0.5395987525843449 1.2865747485567125 0.1982425497575231 1.0 0.6136939068803505 13 Q9NWH9,P31749 2 Tp53 regulates transcription of cell cycle genes 0.5151701255059884 1.26602734311126 0.2055032930716376 1.0 0.6275932028861922 14 P14635 1 Developmental biology 0.3186189544233636 1.2619663766127562 0.2069608854611782 1.0 0.6287005735043465 235 P04350,Q01518,Q03164,P19388,Q16850,Q06323,P62753,P62424,O95239,P49721,P19784,P62263,P62081,P30050,O00487,P31749,P16104,Q04637,Q9NWH9,Q15369,P42766,Q9Y490,Q13951,Q13885,P17612,Q13617,Q00169,Q8TEY7,P62906,P62249,P62910,Q9Y3U8,P62899,P50570,Q71SY5,P62841,O75448,O15145,P32969,P35241,P15880,P26038,Q02750,P62241,P55036,P20936,P61247,P31751,P08865,O43242,O94973,P05388,P07384,P08238,Q14195,P61353,P14923,P18124,P15924,O75832,P18077,P11940,P36507,P62861,P62244,P62269,P39019,P28072,P62750,P40763,P05387,P35659,P68371,Q14997,P62805,Q92542,P35268,Q16539,P62333,O75116,Q96S59 81 Sensory perception 0.4710998528080786 1.2616517172929032 0.2070741377691494 1.0 0.6287005735043465 22 Q6IBS0,P49356,Q6NUM9,P56545,P09455,P26038 6 Nuclear signaling by erbb4 0.8314143084934551 1.2611529182690269 0.2072537578586808 1.0 0.6287005735043465 3 P16949 1 G2 m dna replication checkpoint 0.82981088182844 1.25524922244465 0.2093883019704505 1.0 0.6312618204399869 3 P14635 1 Cobalamin cbl vitamin b12 transport and metabolism 0.8290141505934465 1.2523160669544249 0.2104547165856489 1.0 0.6312618204399869 3 P33527 1 Base excision repair ap site formation 0.689648203137404 1.2511353194035773 0.210885111464131 1.0 0.6312618204399869 5 P13051,P29372,P62805 3 Autophagy 0.4012066603115924 1.248907048750706 0.2116990731981034 1.0 0.6313255388467252 43 P68371,P04350,O95140,Q8WUX9,O43633,O43237,Q8N4H5,Q6IAA8,P61088,P60520,Q9NS69,Q9Y4P1,P54619 13 Pink1 prkn mediated mitophagy 0.6489815761838423 1.2417992621413654 0.2143106350545114 1.0 0.6313255388467252 7 Q9NS69,O95140 2 Telomere c strand lagging strand synthesis 0.4828247634783711 1.2336186256501809 0.2173450492025583 1.0 0.6366298269296053 19 P18858 1 Cytoprotection by hmox1 0.3789688724327499 1.2335706290654356 0.2173629431165098 1.0 0.6366298269296053 62 P55036,O75832,P13073,P09669,O00487,P49721,Q96ST3,P28072,P30519,P09601,P33527,P40763,Q14997 13 Ca2 pathway 0.6667950534050041 1.2261228807330211 0.2201524366805056 1.0 0.6406577332950903 6 Q08209,O43318 2 Signaling by erbb2 0.5831405948768231 1.2089160043836118 0.2266951168470266 1.0 0.6554865187129981 10 Q9UNE7,P31749 2 Cd163 mediating an anti inflammatory response 0.6660649819494546 1.205785735744431 0.2279001168875618 1.0 0.6575716748411816 2 Q16539 1 Robo receptors bind akap5 0.6653429602888048 1.202451344936469 0.2291887062758046 1.0 0.6580847217698268 2 P17612 1 Cd28 co stimulation 0.6397134404491875 1.202275746469608 0.2292567104813974 1.0 0.6580847217698268 7 P31749 1 Foxo mediated transcription 0.5434526852305486 1.2015687539764677 0.2295306535091228 1.0 0.6580847217698268 12 Q96ST3,Q9Y3B8,P31751,P31749 4 Hiv transcription elongation 0.4829911367498039 1.1955582989091782 0.2318689729999246 1.0 0.6588564292823036 18 P19388 1 Akt phosphorylates targets in the cytosol 0.6752414652049743 1.1934104289348422 0.2327086725941911 1.0 0.6588564292823036 5 P31749 1 Tp53 regulates metabolic genes 0.413052319866286 1.187865966929485 0.2348862198160892 1.0 0.6624492030189323 35 P13073,P09669,P31749,P31751,Q6IAA8,Q9Y3B8,Q16881,P54619 8 Mrna splicing minor pathway 0.4390752336304476 1.1845126048371597 0.2362102096501823 1.0 0.6624492030189323 29 P62314,Q15427,Q86XP3,P19388 4 Gaba receptor activation 0.6565610935322418 1.1839953322085022 0.2364149105696704 1.0 0.6624492030189323 6 P04899,Q9Y639 2 Vegfr2 mediated vascular permeability 0.5755082154765381 1.1726311892308956 0.2409437364247733 1.0 0.6702732199409972 10 P31751,P31749 2 Other interleukin signaling 0.8058879643169442 1.1673125240327402 0.2430841827676082 1.0 0.6723689233844615 3 P42574 1 Resolution of sister chromatid cohesion 0.3849902666922621 1.1664830199263296 0.2434192098972936 1.0 0.6723689233844615 53 P68371,Q9HBM1,Q53HL2,Q7Z5K2,P50748,Q9BZD4,O43237,Q2NKX8,O00139,P14635,Q9NTI5 11 Interleukin 4 and interleukin 13 signaling 0.5362785198716429 1.164649025370308 0.244161090491136 1.0 0.6723689233844615 12 P09601,P31749 2 Signaling by fgfr in disease 0.4970462206852162 1.1642158824284126 0.244336535380639 1.0 0.6723689233844615 14 O95429,P19388,Q16630 3 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.5359728402358136 1.1630765287744629 0.2447984540480328 1.0 0.6723689233844615 12 O43318,P09601,P61088,Q15750 4 Pi3k akt signaling in cancer 0.5355932356367706 1.161123824173093 0.2455915474189551 1.0 0.6723689233844615 12 Q9NWH9,P31749 2 Epigenetic regulation of gene expression 0.3980864895529198 1.1581342426486794 0.2468092579080951 1.0 0.673521649592573 37 O15160,O60264,P19388,P62805,Q9H9Y6,O95602,Q96ST3,Q9UHR5,P16104,Q86YP4,P18074,P35659 12 Listeria monocytogenes entry into host cells 0.6282167537556085 1.1532831832209098 0.2487941703071685 1.0 0.6758979500579303 7 Q9NWH9 1 Condensation of prometaphase chromosomes 0.5887268467245046 1.1496598023576354 0.250284016750369 1.0 0.677561710684764 9 O95347,P19784,Q9BPX3,P14635 4 Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.6472779095585133 1.145813255143966 0.2518724294119852 1.0 0.6777786099752213 6 O43318,P61088 2 Aquaporin mediated transport 0.6468312626825251 1.143977254319842 0.2526330701381916 1.0 0.6777786099752213 6 P63218,P17612,Q99797 3 Infectious disease 0.290661073119031 1.1414983135272827 0.2536626134048139 1.0 0.678597424443193 313 Q9UQB8,O75832,P19388,P18077,P36507,P63218,P04899,Q92783,Q9Y3U8,P62899,Q9UER7,P18858,P62841,P49356,P49721,Q14241,O43237,Q13217,Q86YP4,P62861,P04844,Q5SRE5,P17096,P55036,Q96JJ3,O00487,P62244,P62269,P39019,P28072,Q10567,Q9NWH9,O94973,P20339,Q8WUX9,P61353,P42766,P09601,Q9Y3E5 39 Metabolism of fat soluble vitamins 0.7970386421090432 1.1348787688602988 0.2564261167294006 1.0 0.6829636753759 3 P09455,Q6NUM9 2 Transcriptional regulation by mecp2 0.5487865432383486 1.1327154512994633 0.2573337668637778 1.0 0.683040213218504 11 Q13451,Q96ST3,Q9NWH9,Q8WYQ5,P51608 5 Mtorc1 mediated signalling 0.5641693462510076 1.11878354809355 0.2632324919825202 1.0 0.68927351946868 10 Q04637,P06730,Q96B36,Q6IAA8,P42345,Q9Y2Q5,P62753 7 Mitochondrial translation 0.3839966939803452 1.1161696970491586 0.2643495029592002 1.0 0.6895412178916567 48 Q96DV4,Q9Y3D9,Q6P1L8,P82664,Q9Y2R5,O75616,Q9NRX2,Q96E11,P46199,Q96EY7,Q9BRJ2,Q13084,P82675,Q9BYD2,Q14197,Q8TAE8,Q9NQ50,Q15070,Q9Y2Q9 19 E2f mediated regulation of dna replication 0.5626118818617525 1.1113950141366966 0.2663983574950039 1.0 0.6922282367795609 10 P09884,Q9Y619,Q14181,P49642,Q9UBD5,P14635 6 Cargo recognition for clathrin mediated endocytosis 0.4362993625919934 1.0968011374552806 0.2727283328697174 1.0 0.700380460111833 26 Q92783,O94973,Q8NC96,P20645 4 Formation of rna pol ii elongation complex 0.4425758495824557 1.0874344779782583 0.2768448408196193 1.0 0.7022342461398842 23 P19388 1 Regulation of expression of slits and robos 0.3300578570892766 1.0873224965131727 0.2768943098105525 1.0 0.7022342461398842 123 O75832,Q8TEY7,P62906,P18077,P11940,P62249,P62910,Q9Y3U8,P62899,Q06323,P62753,P62424,Q14997,P62841,P49721,P32969,P62263,P62081,P15880,P30050,P62861,P62241,P55036,P35268,O00487,P62244,P62269,P39019,P28072,P62750,Q04637,P61247,Q15369,P08865,O43242,P62333,P05388,P61353,P42766,P18124,P05387,Q13617 42 Estrogen dependent gene expression 0.4402351068523263 1.0867251385333887 0.2771583007612608 1.0 0.7022342461398842 24 P19388 1 Tp53 regulates transcription of dna repair genes 0.4420881075543244 1.0842054878928005 0.2782736989695515 1.0 0.7022342461398842 23 Q14241,P19388 2 Loss of function of mecp2 in rett syndrome 0.7651130514316211 1.0794764557780252 0.2803753839961773 1.0 0.7056113830570464 4 Q96ST3,P51608 2 Constitutive signaling by akt1 e17k in cancer 0.6298125193844983 1.0741242707053495 0.2827669878966166 1.0 0.7088251861283599 6 P31749 1 Nrage signals death through jnk 0.6289031531736835 1.0703988031579474 0.2844398377853823 1.0 0.7088251861283599 6 Q92974,Q9NY61,Q14155 3 Noncanonical activation of notch3 0.6353790613718369 1.0647185306206486 0.2870033218475756 1.0 0.7088251861283599 2 Q92542 1 Signaling by receptor tyrosine kinases 0.3323989468204593 1.0627615663835892 0.287890092972126 1.0 0.7088251861283599 104 Q9UQB8,P21281,P20936,P19388,P31749,Q96ST3,Q9NWH9,P31751,O94973,P04792,Q92783,Q13043,Q9UNE7 13 Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0.7605082850631494 1.0627147409512647 0.2879113338799519 1.0 0.7088251861283599 4 O43318,P61088 2 Adp signalling through p2y purinoceptor 1 0.7769096016061962 1.0613823477168072 0.288516175797243 1.0 0.7090298063444 3 P63218 1 Rab regulation of trafficking 0.418325449142061 1.0575280052329945 0.2902706803627723 1.0 0.7107709092126264 30 P31749,P31751,Q7Z392,Q8IUR0,P60520,P20339,Q9Y3P9 7 Glucuronidation 0.7742867461177242 1.0518400553899272 0.2928729382110195 1.0 0.7145679048990585 3 Q9NUJ1,Q16851 2 Selective autophagy 0.4170574721900383 1.0481869504649242 0.2945524816543674 1.0 0.7166272251900889 30 P68371,P04350,P19784,O43237,P61088,Q8N4H5,Q9NS69,O95140,P54619 9 Amyloid fiber formation 0.7560192096363332 1.046397846006638 0.2953773868353404 1.0 0.7166272251900889 4 Q92542,P62805 2 Death receptor signalling 0.4355491467026079 1.0409700938742776 0.2978894282085123 1.0 0.7166272251900889 23 O43318,Q9NY61,Q92542,Q8TCT8,P52565,P42574,O95429 7 Global genome nucleotide excision repair gg ner 0.3993270551308821 1.036541630331161 0.2999495282290767 1.0 0.7189266470252473 34 P49916,P18858,P35244,Q9UGN5,P61088,P18074,Q07864 7 Transcription of the hiv genome 0.4378382049039492 1.034091123735979 0.3010935654655458 1.0 0.719132083422982 21 P19388 1 Suppression of phagosomal maturation 0.6187705284894014 1.0289497611938851 0.3035032832448419 1.0 0.7231486825922052 6 P20339 1 Influenza infection 0.3265735021044587 1.0251633275965315 0.3052861287390402 1.0 0.7240555828208651 121 P19388,Q86U42,P62906,P18077,P62249,P62910,Q9Y3U8,P62899,P62753,O00505,P62424,P52294,P62841,P32969,P62263,P62081,P15880,Q13217,P30050,P62861,Q9BVL2,P62241,Q5SRE5,P35268,P62244,P62269,P39019,P62750,P61247,P08865,P05388,P61353,P42766,P27797,P18124,P05387 36 P75 ntr receptor mediated signalling 0.4669191830741911 1.0150146011233148 0.3100988674511118 1.0 0.7303715092999323 15 P42575,Q9NY61,Q14155,Q92542,P52565,Q92974,P42574 7 Metalloprotease dubs 0.6069832908216919 0.9809040807023632 0.3266400449606257 1.0 0.7562245674642084 6 O00487 1 Kinesins 0.4413264192823256 0.9782999454431492 0.3279259968959644 1.0 0.7566825009789576 19 P68371,P04350,Q02241,O95239,Q12756,Q99661,Q9H0H5,O00139 8 Gaba synthesis release reuptake and degradation 0.6158844765342915 0.9760861277409062 0.3290217851982473 1.0 0.7578654340413866 2 P51649 1 G alpha s signalling events 0.6045308481032067 0.970935303746964 0.3315804964985673 1.0 0.7611788762526234 6 P04899,Q9Y3E5 2 Vasopressin regulates renal water homeostasis via aquaporins 0.6180869554941554 0.965706618146762 0.3341910069091822 1.0 0.7616668227053709 5 P17612,P63218,P10644 3 Glucagon signaling in metabolic regulation 0.6180869554941554 0.965706618146762 0.3341910069091822 1.0 0.7616668227053709 5 P17612,P63218,P10644 3 Stat3 nuclear events downstream of alk signaling 0.7334138049510308 0.9646553966500506 0.33471744279661 1.0 0.7616668227053709 4 Q96ST3 1 Rab gefs exchange gtp for gdp on rabs 0.4169793571952567 0.9637345936631648 0.3351790058869484 1.0 0.7616668227053709 26 P31749,P31751,Q7Z392,Q8IUR0,P20339 5 Cilium assembly 0.3643072438435148 0.96050636628584 0.3368004284562089 1.0 0.7625915437743751 52 A6NIH7,Q96A65 2 Rhof gtpase cycle 0.4571042207605593 0.9596206942730232 0.3372461499693888 1.0 0.7625915437743751 15 Q5JTV8,P80723,Q9NSV4,O00161 4 E2f enabled inhibition of pre replication complex formation 0.7315992593350796 0.9581293128569032 0.3379975559542054 1.0 0.7630210607006066 4 Q9UBD5,P14635 2 Regulation of tp53 expression and degradation 0.4953846468044064 0.9553210671542636 0.339415356923658 1.0 0.7649510282906322 12 P31751,P31749 2 Mitophagy 0.5270061817906808 0.9434183658979232 0.3454669527250087 1.0 0.7760158491789865 10 Q8N4H5,Q9NS69,O95140 3 Iron uptake and transport 0.4450608344711394 0.9376759119391652 0.3484109864799984 1.0 0.7802181957906651 17 P21281,P30519,P21283,P02786,P09601 5 Polo like kinase mediated events 0.7426378091324611 0.937530040839354 0.3484859785466767 1.0 0.7802181957906651 3 P14635 1 Regulation of beta cell development 0.7415744352497202 0.9337207766101934 0.350447944825941 1.0 0.7833203240435095 3 P31749 1 Rhoj gtpase cycle 0.4372611264212097 0.921127344975574 0.3569839451549095 1.0 0.7928570146793781 18 Q01968,Q14155,P14923,P02786,Q9NSV4,Q6IAA8,Q15758,P42166,O00161 9 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.5217746982896433 0.918956858170849 0.3581181381259042 1.0 0.7928570146793781 10 P51648,P09601 2 Glucagon like peptide 1 glp1 regulates insulin secretion 0.5915875508116973 0.9185100765974727 0.3583518859545787 1.0 0.7928570146793781 6 P63218,P17612,P10644 3 Cholesterol biosynthesis 0.4416181288646027 0.9176570725740923 0.3587984282765397 1.0 0.7928570146793781 17 Q16850,Q15392 2 Nod1 2 signaling pathway 0.5365044812121669 0.9123558365821686 0.3615814298563231 1.0 0.7977096804784791 9 O43318,P61088,Q15750 3 Synthesis of pips at the plasma membrane 0.570319618279058 0.9085548962812088 0.363585123984629 1.0 0.7991335163937221 7 P20339,Q01968 2 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.7171884773753077 0.9065235951077856 0.364658781905202 1.0 0.7991335163937221 4 Q96ST3 1 Synthesis of pc 0.6015794912165564 0.9007774399027222 0.3677066648626259 1.0 0.7993103775888042 5 P35790 1 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.5319228878484478 0.8917983180296845 0.3725010434129383 1.0 0.799729728275171 9 Q10567 1 Dna damage telomere stress induced senescence 0.4464042065504132 0.8821464932431055 0.3776975926125476 1.0 0.8080720640108721 14 P07305,P10412,P17096,P16403 4 Establishment of sister chromatid cohesion 0.5607580841030702 0.8687372567478614 0.3849908583388854 1.0 0.8184953713988982 7 Q7Z5K2 1 Adora2b mediated anti inflammatory cytokines production 0.5265756039594072 0.8678842221132971 0.3854577172150808 1.0 0.8184953713988982 9 P04899,Q9Y3E5 2 Signaling by alk 0.5915078653081991 0.8614610723437889 0.3889841521805446 1.0 0.8208532031263356 5 Q96ST3 1 Factors involved in megakaryocyte development and platelet production 0.3570315025578084 0.8546822364362687 0.3927270871413333 1.0 0.8265001017574878 39 P68371,P04350,Q02241,Q9H4M9,O95239,Q12756,Q96ST3,Q99661,P17612,Q13885,Q9H0H5,O00139,P20339,O95140 14 Nade modulates death signalling 0.7181633511604053 0.850510590893302 0.3950412747469203 1.0 0.8282576874953002 3 P42574 1 Mitotic g1 phase and g1 s transition 0.3285704776990986 0.8445037925988438 0.3983879449445289 1.0 0.8282576874953002 74 P55036,O00487,P31749,P49721,P00374,P31751,P35244,P14635,Q07864 9 Cytosolic sulfonation of small molecules 0.5696845225500192 0.8306844688147488 0.4061519024779816 1.0 0.8388082249633455 6 Q8TB61 1 Condensation of prophase chromosomes 0.5022303257286476 0.8283214019041264 0.4074885054887667 1.0 0.8388082249633455 10 P14635 1 Signaling by wnt 0.3205008538158504 0.8266452376647366 0.4084381688443896 1.0 0.8388082249633455 79 O75832,Q14738,Q08209,P63218,Q06323,Q14997,P62805,P49721,P19784,P55036,O00487,O43318,P31749,P28072,P31751,P62333,O94973,O75436,P56545 19 Extension of telomeres 0.3934382240249501 0.8212903748854359 0.4114808888973966 1.0 0.8421724819451236 27 P18858 1 Sealing of the nuclear envelope ne by escrt iii 0.5137679549408944 0.8110004014805829 0.4173654401918352 1.0 0.8492606985856636 9 Q8WUX9,P04350,O43633,P68371 4 Transcriptional regulation by tp53 0.3130822469030764 0.8058590186289953 0.4203241433446678 1.0 0.8492606985856636 107 P19388,Q6IAA8,Q9UER7,Q16881,P14635,A5YKK6,Q14004,P19784,Q14241,Q86YP4,P35244,P18074,P13073,P42771,Q04917,P31749,Q16539,P15954,P31751,Q15369,Q96KQ7,P09669,Q8WX92,Q9Y3B8,P54619 25 Uptake and function of anthrax toxins 0.705308775731311 0.805435529334643 0.4205683959883382 1.0 0.8492606985856636 3 Q02750,P36507 2 Energy dependent regulation of mtor by lkb1 ampk 0.5448959832272855 0.8032793319692179 0.4218133011256846 1.0 0.8505107955931831 7 Q9Y376,P54619 2 Rhog gtpase cycle 0.3722899072174798 0.794112977776648 0.4271296631167256 1.0 0.8561492804950297 33 O95202,P34897,Q96JJ3,O15173,P84095,O75489,P02786,Q9NSV4,P52565,P61604,Q86UP2,Q6IAA8,P42166,P42167,Q16718,Q86XL3,O15498 17 Cyclin a cdk2 associated events at s phase entry 0.3493822241532001 0.7877307923040824 0.4308541902027483 1.0 0.8586776517206077 42 P55036,O75832,O00487,P31749,P49721,P31751 6 Endosomal sorting complex required for transport escrt 0.540848290625233 0.7867138671452257 0.4314493845200862 1.0 0.8586776517206077 7 Q8WUX9,Q92783 2 Rho gtpase effectors 0.3102670319938287 0.7771899868270253 0.4370466889666802 1.0 0.8622561579693809 101 P68371,Q9UQB8,P04350,P84095,Q53HL2,P62805,Q99661,O43237,Q9BZD4,Q2NKX8,Q9HBM1,Q04917,P50748,Q16539,O43663,O75116,Q9NSV4,O00139,Q9Y3B8 19 Cohesin loading onto chromatin 0.5206833249645677 0.777005333116321 0.4371556238711578 1.0 0.8622561579693809 8 Q7Z5K2 1 Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0.6962802455760126 0.7740819962141132 0.4388823034679829 1.0 0.8631563681808812 3 P16104,P62805 2 Flt3 signaling 0.5637712693532175 0.7547140657873813 0.4504205650002002 1.0 0.8718156089103438 5 P31749 1 Gaba b receptor activation 0.5633047763492935 0.752941374903115 0.4514851437071618 1.0 0.8718156089103438 5 P04899 1 G alpha z signalling events 0.5633047763492935 0.752941374903115 0.4514851437071618 1.0 0.8718156089103438 5 P04899 1 Adp signalling through p2y purinoceptor 12 0.5633047763492935 0.752941374903115 0.4514851437071618 1.0 0.8718156089103438 5 P04899 1 Darpp 32 events 0.5141809927516253 0.7495985887313682 0.4534965010601754 1.0 0.8718156089103438 8 P17612,Q08209,Q14738,P10644 4 Sumo is conjugated to e1 uba2 sae1 0.5646209386281537 0.7495107850632066 0.4535494006619669 1.0 0.8718156089103438 2 Q9UBT2 1 Sumo is transferred from e1 to e2 ube2i ubc9 0.5646209386281537 0.7495107850632066 0.4535494006619669 1.0 0.8718156089103438 2 Q9UBT2 1 Processing and activation of sumo 0.5646209386281537 0.7495107850632066 0.4535494006619669 1.0 0.8718156089103438 2 Q9UBT2 1 Tbc rabgaps 0.4526657509691095 0.7418018966960767 0.4582073712406305 1.0 0.8782846509393749 12 P20339,P60520 2 Ctla4 inhibitory signaling 0.5459386328198741 0.7371676950125335 0.4610203762430473 1.0 0.8817245499761668 6 P31749 1 Transcriptional regulation by runx1 0.3301346704525393 0.7367085619275222 0.4612995989941535 1.0 0.8817245499761668 62 P55036,O00487,Q03164,P49721,Q96ST3,Q13951 6 Deactivation of the beta catenin transactivating complex 0.5107629241094616 0.7352688643266415 0.4621757664970209 1.0 0.8819449928897475 8 P31749 1 S phase 0.3026078799983689 0.7310419401260433 0.4647535359461172 1.0 0.8819449928897475 89 P18858,P55036,O75832,Q7Z5K2,O00487,Q9NTI5,P31749,Q9BRX5,P49721,Q16763,P28072,P31751,P35244,Q9UBD5,Q07864 15 Vitamin d calciferol metabolism 0.5595667870036047 0.7278856430134661 0.4666835924560044 1.0 0.8819449928897475 2 P38435 1 Regulation of lipid metabolism by pparalpha 0.4117263513645915 0.7246889889216163 0.4686428517292484 1.0 0.8821130685596241 16 O75448,Q15067,Q96ST3,Q71SY5,P23786 5 Apoptotic cleavage of cell adhesion proteins 0.554637491501971 0.720163546884227 0.4714243052584876 1.0 0.8848972801744265 5 P42574 1 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.6626848905181554 0.7161655670014675 0.4738891217612897 1.0 0.887885428396247 4 P31749 1 Metabolism of cofactors 0.5524640571209054 0.7119932832495506 0.476468935307502 1.0 0.8882322127337383 5 P31749 1 Biological oxidations 0.3401179558753867 0.7088540375579202 0.4784150600832768 1.0 0.8889270103946518 43 O43169,Q8TB61,O75223,P22570,Q9NUJ1,Q16850 6 Late endosomal microautophagy 0.5201902480195988 0.7032227306917482 0.4819169556956546 1.0 0.8924604640545793 7 Q8WUX9 1 Met activates ras signaling 0.6572441878417744 0.6977086469050718 0.4853594194380879 1.0 0.8925621799950764 4 Q9NWH9 1 Runx3 regulates p14 arf 0.6682643587118995 0.6786836650593852 0.4973383184196167 1.0 0.9089388899931138 3 Q13951 1 The role of nef in hiv 1 replication and disease pathogenesis 0.4544987410483362 0.6782567299181992 0.4976089287379519 1.0 0.9089388899931138 11 Q10567 1 Apc c cdc20 mediated degradation of cyclin b 0.4953936819240295 0.671569636614517 0.501857713596185 1.0 0.9105277261019658 8 P14635 1 Creb1 phosphorylation through the activation of adenylate cyclase 0.665583243048026 0.6697236790838118 0.5030339539711708 1.0 0.9105277261019658 3 P17612,P10644 2 Pka mediated phosphorylation of creb 0.665583243048026 0.6697236790838118 0.5030339539711708 1.0 0.9105277261019658 3 P17612,P10644 2 Pka activation in glucagon signalling 0.665583243048026 0.6697236790838118 0.5030339539711708 1.0 0.9105277261019658 3 P17612,P10644 2 Tnfr1 induced nfkappab signaling pathway 0.6460227900894839 0.6600319513413017 0.5092333255010566 1.0 0.916619985901902 4 O43318 1 Dual incision in gg ner 0.383058002541398 0.6586752554841754 0.5101043259764761 1.0 0.9169732526481892 20 P35244,Q07864 2 Displacement of dna glycosylase by apex1 0.6609839477655999 0.6544297929221687 0.5128349451629348 1.0 0.920264755144943 3 P13051 1 Mitochondrial calcium ion transport 0.3999878237173994 0.6464264913737083 0.5180031886183869 1.0 0.9203978058228484 15 Q96TA2,Q8NE86 2 Butyrate response factor 1 brf1 binds and destabilizes mrna 0.4475214436459594 0.6462696722991997 0.518104725132067 1.0 0.9203978058228484 11 P31749 1 Clec7a dectin 1 signaling 0.3310675142875303 0.6424740214749095 0.5205654516753322 1.0 0.9211832106685824 49 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,Q8TBC4,Q08209,P61088,Q14997 11 Prc2 methylates histones and dna 0.6385778220225207 0.6353467912763378 0.5252022625971469 1.0 0.9232320977393424 4 P62805 1 Signaling by ptk6 0.3990582615849354 0.6287553418576614 0.5295092408264794 1.0 0.9245807923834408 14 P20936,Q96JJ3,P31749 3 Negative regulation of notch4 signaling 0.3288164179807913 0.6156241879191469 0.538142583504861 1.0 0.9302438680447171 41 P55036,O75832,O00487,P31749,P49721 5 Anti inflammatory response favouring leishmania parasite infection 0.4112354699046876 0.6136533687777421 0.5394444088572992 1.0 0.9302438680447171 13 P04899,Q9Y3E5 2 Processing of smdt1 0.4515850004327804 0.6019449508390202 0.5472107814005562 1.0 0.9309118565045384 10 Q8NE86 1 Signaling by met 0.3937229633774616 0.6013484846703981 0.5476079027002694 1.0 0.9309118565045384 14 Q92783,P40763,Q9NWH9 3 Adrenaline noradrenaline inhibits insulin secretion 0.6275732005066089 0.5993549952807643 0.5489361815430014 1.0 0.9309118565045384 4 P04899 1 Unblocking of nmda receptors glutamate binding and activation 0.6270565304755306 0.5976804949421944 0.5500531425850952 1.0 0.9309118565045384 4 P07196 1 Long term potentiation 0.6270565304755306 0.5976804949421944 0.5500531425850952 1.0 0.9309118565045384 4 P07196 1 Ras activation upon ca2 influx through nmda receptor 0.6270565304755306 0.5976804949421944 0.5500531425850952 1.0 0.9309118565045384 4 P07196 1 Recognition of dna damage by pcna containing replication complex 0.3833577648395432 0.5901774573739662 0.5550716836273182 1.0 0.9335921015464425 17 P35244 1 Termination of translesion dna synthesis 0.3828523997973366 0.5874718455466866 0.5568868539110798 1.0 0.934454717688996 17 P35244 1 Regulation of mecp2 expression and activity 0.4901947897439078 0.5859396834893646 0.5579160485613044 1.0 0.934454717688996 7 Q96ST3 1 Transcriptional regulation of white adipocyte differentiation 0.4731108907087068 0.5817434264649036 0.5607395157418789 1.0 0.934454717688996 8 Q71SY5 1 Signal amplification 0.4730522780939615 0.5815116934817838 0.5608956395150804 1.0 0.934454717688996 8 P63218,P04899 2 Triglyceride catabolism 0.5047645784327706 0.5810978034648016 0.5611745389633513 1.0 0.934454717688996 6 P17612,Q01469,P62136 3 Triglyceride metabolism 0.5047645784327706 0.5810978034648016 0.5611745389633513 1.0 0.934454717688996 6 P17612,Q01469,P62136 3 Diseases of signal transduction by growth factor receptors and second messengers 0.2899209646944728 0.5792685309994627 0.5624079957570525 1.0 0.934454717688996 132 O75832,P19388,P36507,Q8IWJ2,Q96PU8,P49721,P26038,O95429,P55036,O00487,P31749,P49589,P28072,Q9NWH9,P31751,P56545,Q14789,P51608,Q16630 19 Translation 0.281297283210911 0.5779929239549465 0.5632688965721828 1.0 0.934454717688996 209 P54577,P62906,Q5ST30,Q96DV4,P67812,Q5JTZ9,Q9Y3D9,P18077,P08240,Q6P1L8,P11940,P52815,P62249,P62910,Q9Y3U8,P62899,P62753,Q9Y2R5,P62424,P82664,P62841,O75616,Q9NRX2,P32969,P62263,P62081,P15880,P46199,P43307,Q96E11,P30050,P62861,Q96EY7,Q9BRJ2,P04844,P82673,P62241,Q5JPH6,Q13084,P04843,Q8N5N7,Q9BW92,P35268,P62244,P82675,P62269,Q9BYD2,P49589,P39019,P62750,Q04637,P61247,Q8TAE8,Q14197,P08865,Q15070,Q9NQ50,Q7L2H7,O60841,P05388,P61353,P42766,Q9Y2Z4,P18124,Q14152,Q9Y2Q9,P05387,O75822,O00303 69 Myoclonic epilepsy of lafora 0.5231046931407883 0.5772666371269017 0.5637593476662643 1.0 0.934454717688996 2 P13807 1 Meiotic recombination 0.4457303522689518 0.5768929035451412 0.564011804759917 1.0 0.934454717688996 10 P35244,P62805 2 Regulation of runx2 expression and activity 0.3227104092163326 0.5649814250399879 0.5720863984862101 1.0 0.9433605531415112 42 P55036,O75832,O00487,P49721,Q13951,Q9UNE7 6 Mitotic telophase cytokinesis 0.4289195657823861 0.5628968739939914 0.5735051089686951 1.0 0.9435755969593904 11 Q7Z5K2,Q9NTI5 2 Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.3655101849537751 0.5571898491964195 0.5773977243612964 1.0 0.9465422284764798 20 P35244 1 Phosphorylation of the apc c 0.4522893460905032 0.5496330183544671 0.5825711071756117 1.0 0.952724590435206 9 P14635 1 Clathrin mediated endocytosis 0.3206527339241319 0.5482669191402787 0.5835086385540373 1.0 0.953110865138145 46 Q01968,O94973,P20645,Q8NC96,Q92783,P20339 6 Lysosome vesicle biogenesis 0.3971201952846475 0.5454610089088576 0.5854364903219211 1.0 0.95388808619614 13 P20645 1 Formation of the beta catenin tcf transactivating complex 0.4629342107110349 0.541909492861898 0.5878808568947487 1.0 0.9554365326461592 8 P16104,Q9Y265,P51532,P62805 4 Tnf signaling 0.4769633493041203 0.5360850080672659 0.5918998008673846 1.0 0.9564706651352862 7 O95429,O43318,Q8TCT8 3 Recognition and association of dna glycosylase with site containing an affected purine 0.6073288117431466 0.5348615294227516 0.5927456121126813 1.0 0.9566998656308005 4 P29372,P62805 2 Class i peroxisomal membrane protein import 0.490317634406603 0.5287744170261575 0.5969619467285467 1.0 0.9612219023745202 6 P51648 1 Egfr downregulation 0.4893174313390589 0.5252080670270293 0.599438557605211 1.0 0.96292789572752 6 O14964,Q92783 2 C type lectin receptors clrs 0.3162661118818035 0.5232709753368437 0.6007856961085154 1.0 0.9639524923394008 51 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,Q8TBC4,Q08209,P61088,Q14997 11 Separation of sister chromatids 0.2868852121276823 0.5170029326678208 0.6051541116178081 1.0 0.9675346325748247 94 P68371,P04350,O75832,Q14738,Q06323,Q14997,Q53HL2,P49721,Q99661,O43237,Q9BZD4,Q2NKX8,Q9NTI5,P55036,Q9HBM1,O00487,P50748,Q16763,P28072,P62333,Q7Z5K2,O00139 22 Lipophagy 0.616106897797036 0.5110605356218505 0.609308668800228 1.0 0.9702483138272128 3 O60664,P54619 2 Regulation of runx3 expression and activity 0.3147202417807966 0.5105969993745975 0.6096332774204543 1.0 0.9702483138272128 38 P55036,O75832,O00487,P49721,Q13951 5 Formation of the cornified envelope 0.5979371852742241 0.5057809670292684 0.6130104212566878 1.0 0.9702483138272128 4 P14923 1 Keratinization 0.5979371852742241 0.5057809670292684 0.6130104212566878 1.0 0.9702483138272128 4 P14923 1 E3 ubiquitin ligases ubiquitinate target proteins 0.3695134551086435 0.502043119590586 0.6156371898891528 1.0 0.9702483138272128 16 Q9BUN8,Q14527 2 Fceri mediated nf kb activation 0.3149172093332351 0.5013388508527103 0.6161326672795324 1.0 0.9702483138272128 45 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,P61088,Q14997 9 Assembly of the orc complex at the origin of replication 0.4663191426105304 0.4969775914006812 0.6192048536110231 1.0 0.9728316717426364 7 Q9UBD5,P16104,P52294,P62805 4 Transport of inorganic cations anions and amino acids oligopeptides 0.4657261451033709 0.4948271364001649 0.6207221474403908 1.0 0.9740893745629228 7 Q9UBX3,Q70HW3 2 Signaling by robo receptors 0.282563243246438 0.4932776566225834 0.6218164135660635 1.0 0.9746810911606464 134 O75832,Q8TEY7,Q01518,P62906,P18077,P11940,P62249,P62910,Q9Y3U8,Q06323,P62753,P62899,P62424,Q14997,P62841,P49721,P32969,P62263,P62081,P15880,P30050,P62861,P62241,P55036,P35268,O00487,P62244,P62269,P39019,P28072,P62750,Q04637,P61247,Q15369,P08865,O43242,P62333,P05388,P61353,P42766,P18124,P05387,P17612,Q13617 44 Rhobtb3 atpase cycle 0.6056073829744855 0.4793022890106095 0.6317235939811663 1.0 0.987931374246726 3 O14964 1 Rhob gtpase cycle 0.3586974913146665 0.4782335699176832 0.6324839717290331 1.0 0.9879835834250068 18 O75116,P14923,P02786,Q9NQW6,Q9NSV4,Q9H0H5,Q92974,O00161 8 Opioid signalling 0.3639165397229467 0.4742119900810927 0.6353487440497909 1.0 0.9892350984046232 16 Q08209,P04899 2 Beta catenin independent wnt signaling 0.3092554178478049 0.4726188519159806 0.6364851302695507 1.0 0.9892350984046232 53 P55036,O75832,O43318,O00487,P49721,Q08209,P63218,O94973 8 Metabolism of steroids 0.3089803466178644 0.4638127490310226 0.6427819084170721 1.0 0.9892350984046232 39 Q16850,Q15392,P22570 3 Interleukin 1 signaling 0.3098858665808313 0.4618534340192821 0.6441864292700497 1.0 0.9892350984046232 46 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,P61088,Q14997 9 Amino acids regulate mtorc1 0.3922512936835062 0.4612776909189306 0.6445993884735159 1.0 0.9892350984046232 12 P21281,P36543,P21283,Q6IAA8,P42345 5 The role of gtse1 in g2 m progression after g2 checkpoint 0.308435964909187 0.4538513917206128 0.6499357914249408 1.0 0.9902631589413382 49 P68371,O75832,P04350,P55036,O00487,P49721,P28072,P62333,P14635,Q14997 10 Aggrephagy 0.3590863198705105 0.4505891815217321 0.6522856652648654 1.0 0.9904538760837456 16 P68371,P04350,O43237,P61088 4 Activation of ampk downstream of nmdars 0.4517888346640391 0.4452097979431173 0.6561681467149276 1.0 0.9940677527383294 7 P68371,P04350,P54619 3 Costimulation by the cd28 family 0.3878278838555434 0.4422960283640255 0.6582750045717489 1.0 0.9940677527383294 12 P31749 1 Downstream signaling events of b cell receptor bcr 0.306877942548549 0.4388310058799227 0.6607839920067957 1.0 0.9940677527383294 44 P55036,O75832,O43318,O00487,P49721,Q08209 6 Metabolism of nitric oxide nos3 activation and regulation 0.4642372094363849 0.4384639150126014 0.6610500228510312 1.0 0.9940677527383294 6 P31749 1 Auf1 hnrnp d0 binds and destabilizes mrna 0.3059844639047095 0.4343974054015945 0.6639998815515349 1.0 0.9940677527383294 42 P55036,O75832,O00487,P49721,P04792,P11940 6 Interleukin 1 family signaling 0.3061222917411419 0.4340266016805819 0.664269123787391 1.0 0.9940677527383294 48 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,P40763,P61088,Q14997 10 Programmed cell death 0.2804202922131706 0.4262143984892102 0.6699516266210648 1.0 0.9940677527383294 98 O75832,P07305,P52294,Q14997,P16403,P49721,P55036,O00487,Q04917,P31749,P28072,P31751,P40763,P62333,Q8WUX9,P10412,Q9Y3B8,P42574,O15294,Q9UNE7,P15924 21 Acyl chain remodeling of cl 0.5873958805172628 0.4261115898992907 0.6700265353262029 1.0 0.9940677527383294 3 Q6UWP7 1 Enos activation 0.5705359861671176 0.42441292645382 0.6712646951793884 1.0 0.9948186703912636 4 P31749 1 Pyroptosis 0.4448861419058505 0.421334184484549 0.6735110714311128 1.0 0.9970605077068434 7 Q8WUX9,P42574 2 Signaling by notch4 0.303490082885254 0.4142016824564138 0.67872640976261 1.0 0.9989910470040624 43 P55036,O75832,O00487,P31749,P49721 5 Regulation of ras by gaps 0.3019753943889482 0.4118136437373352 0.6804760202679787 1.0 0.9989910470040624 39 P55036,O75832,P20936,O00487,P49721,P28072,Q14997 7 Dna damage bypass 0.3335218642658126 0.4084377613850656 0.6829523151262831 1.0 0.9989910470040624 23 P35244 1 Intrinsic pathway for apoptosis 0.3339875208366399 0.4068349030989811 0.6841292498097948 1.0 0.9989910470040624 21 P31749,P31751,P40763,P42574,Q9Y3B8 5 Transmission across chemical synapses 0.301529770806875 0.4032212294404855 0.6867854835015867 1.0 0.9989910470040624 41 P63218,O75915,P07196,Q9Y639,P35609,P04899,O94973,P49593,P54619 9 Mitotic metaphase and anaphase 0.2790788763260819 0.4013763989030008 0.6881430228851364 1.0 0.9989910470040624 125 P68371,P04350,O75832,Q14738,Q06323,P14635,Q14997,Q53HL2,P49721,Q99661,O43237,P30260,Q9BZD4,Q2NKX8,Q5SRE5,Q9NTI5,P55036,Q9HBM1,O00487,P50748,Q16763,P28072,Q99986,P62333,Q8WUX9,Q7Z5K2,O43633,O00139,Q86XL3 29 Post translational modification synthesis of gpi anchored proteins 0.4629597694872999 0.4002236775108658 0.6889917766539491 1.0 0.9989910470040624 5 Q92643 1 Attenuation phase 0.3765682292556739 0.395231733726343 0.6926718750109626 1.0 0.9989910470040624 12 P04792 1 Deposition of new cenpa containing nucleosomes at the centromere 0.4486699054435966 0.3875321473259258 0.6983622904470259 1.0 0.9989910470040624 6 O60264,P62805 2 Tcf dependent signaling in response to wnt 0.2963460219250569 0.3862353880836861 0.6993223473948564 1.0 0.9989910470040624 57 P55036,O75832,O00487,P62805,P31749,P49721,P28072,P19784,Q14738,P31751,P62333,Q06323,Q14997 13 Phospholipid metabolism 0.3047208731380998 0.3815795577715654 0.7027732494708361 1.0 0.9989910470040624 36 O95674,Q8NCC3,P35790,P20339 4 Rhoq gtpase cycle 0.3380640550006099 0.3752979958860686 0.7074388564639877 1.0 0.9989910470040624 18 P14923,P02786,Q9NSV4,Q68EM7,Q6IAA8,Q15758,O00161 7 Regulation of hmox1 expression and activity 0.2981591891478395 0.373608776964869 0.7086954030095314 1.0 0.9989910470040624 44 P55036,O75832,O00487,P49721,P28072,P09601,P62333,Q06323,Q14997 9 Retrograde transport at the trans golgi network 0.3427255425454881 0.3735955551040969 0.7087052413882877 1.0 0.9989910470040624 16 P53365,P20645 2 Apoptosis 0.2702553410868981 0.3723962146386486 0.7095978718720413 1.0 0.9989910470040624 87 P55036,O75832,O00487,P10412,Q04917,P16403,P31749,P49721,Q14997,P28072,P31751,P07305,P40763,P42574,Q9Y3B8,P52294,P15924 17 Hdr through mmej alt nhej 0.4154431994028412 0.3689187027287278 0.7121883223920271 1.0 0.9989910470040624 8 Q9UGN5 1 Raf activation 0.4044748071698844 0.3682663497150156 0.7126746411328868 1.0 0.9989910470040624 9 Q9UQ13,Q14738,P36507 3 Pi metabolism 0.3573271094916311 0.3670306407928175 0.7135961625281844 1.0 0.9989910470040624 13 Q01968,Q10713,Q96T51,Q8N9F7,P20339 5 Dna strand elongation 0.3180383507143224 0.3613999704105584 0.717800470114293 1.0 0.9989910470040624 29 P18858 1 Nicotinamide salvaging 0.5636181844657819 0.3606839195906323 0.7183357469846641 1.0 0.9989910470040624 3 P43490 1 Glutamate and glutamine metabolism 0.4259761878171165 0.3585584279158126 0.7199254511528148 1.0 0.9989910470040624 7 P32322 1 Detoxification of reactive oxygen species 0.4006895872419443 0.3550705345486234 0.7225367502926892 1.0 0.9989910470040624 9 P04179,Q16881 2 Mitotic spindle checkpoint 0.2949371205619847 0.3493202982245922 0.7268488613499395 1.0 0.9989910470040624 45 Q9HBM1,Q53HL2,P50748,Q16763,O43237,Q9BZD4,Q2NKX8,O00139 8 Mitotic prometaphase 0.2768982436421168 0.3485500838685326 0.7274271074764633 1.0 0.9989910470040624 78 P68371,Q9HBM1,P04350,Q53HL2,Q7Z5K2,P50748,Q99661,Q14738,O43237,Q9BZD4,Q9BSJ2,Q96CW5,Q2NKX8,Q9BPX3,O00139,P14635,Q9NTI5 17 Slc mediated transmembrane transport 0.3348800033567036 0.3482433748270895 0.7276574155939957 1.0 0.9989910470040624 17 Q8TB61,Q8TAD4,Q70HW3,Q99808,Q9UBX3 5 Inactivation of cdc42 and rac1 0.4599277978339282 0.3477274044214619 0.7280449137663634 1.0 0.9989910470040624 2 P60953 1 Chaperone mediated autophagy 0.4352856109905871 0.3457799964135556 0.7295080594643941 1.0 0.9989910470040624 6 P11142,O60664,P07900,P08670,P08238 5 Synthesis of pips at the golgi membrane 0.4341811073695745 0.3424245212680577 0.7320314373506347 1.0 0.9989910470040624 6 Q10713,Q01968 2 Early phase of hiv life cycle 0.4070404646659995 0.3409821309147792 0.7331170339468926 1.0 0.9989910470040624 8 P18858 1 Rna polymerase ii transcription 0.2679421528439196 0.3375261354776832 0.7357203135974368 1.0 0.9989910470040624 256 O75832,Q9UHY1,Q03164,P19388,Q86U42,Q6IAA8,Q71SY5,Q9UER7,P82979,Q06323,P14635,Q16881,Q14997,A5YKK6,O75448,Q14004,P62805,P49721,Q96ST3,Q13451,P19784,Q14241,P30260,Q86YP4,P35244,P18074,P55036,P13073,O00148,O00487,P42771,Q04917,P31749,Q16539,P15954,P16104,Q16763,P28072,Q9NWH9,P31751,Q15369,Q92797,Q8WYQ5,P62333,Q96KQ7,Q92989,P09669,Q9NQG5,P04179,Q13951,Q9H814,Q8WX92,P51608,Q9Y3B8,Q9UNE7,P35659,P54619 57 Hsf1 dependent transactivation 0.3369174340037144 0.3335871900941023 0.7386910859044562 1.0 0.9989910470040624 14 O75190,P04792,Q96B36,P42345,P08238 5 Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0.3725001536300479 0.3334470523626586 0.7387968506817935 1.0 0.9989910470040624 11 P16104,Q86YP4,Q96KQ7,P62805 4 Vesicle mediated transport 0.2670757598293086 0.3322558044379952 0.7396961089444325 1.0 0.9989910470040624 215 P68371,Q02241,Q15102,P68402,O00461,Q8WTV0,Q8IWJ2,Q92783,Q12756,Q99661,O43237,P20645,Q5JRA6,Q96A65,O15498,Q96KP1,Q01968,Q04917,P31749,Q14671,Q10567,P31751,Q7Z392,Q9H0H5,Q8NC96,P60520,P53365,O95721,O94973,P20339,Q9Y3P9,O15260,Q8WUX9,O43633,Q14789,Q9NVZ3,Q8TAG9,Q8IUR0,O00161,O00139,Q9Y3B8,P54619 42 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.4306807415523954 0.3318845883231612 0.7399764081845936 1.0 0.9989910470040624 6 P20936 1 Dissolution of fibrin clot 0.5511014806789447 0.3282593352315907 0.7427155879329561 1.0 0.9989910470040624 3 P07355,P35237 2 Negative feedback regulation of mapk pathway 0.5346849744560362 0.327066846836654 0.7436173264042234 1.0 0.9989910470040624 4 P36507 1 Glycerophospholipid biosynthesis 0.3174472032582456 0.3267610653055671 0.743848609659536 1.0 0.9989910470040624 24 Q8NCC3,P35790 2 Regulation of pten stability and activity 0.2910109160338303 0.3224663571286262 0.7470994207690296 1.0 0.9993342211236552 44 P55036,O00487,P31749,P49721,P31751,Q9UNE7 6 G alpha 12 13 signalling events 0.4009271848622759 0.3212447834632984 0.748024896846726 1.0 0.9993342211236552 8 O75116,P63218,Q92974,Q14155 4 Signal transduction by l1 0.4006966101704564 0.3205103519067403 0.748581484255983 1.0 0.9993342211236552 8 P19784,P36507 2 Fc epsilon receptor fceri signaling 0.2894377448921386 0.3165912238828265 0.7515537958253049 1.0 1.0 53 P55036,O75832,O43318,O00487,Q15750,P49721,P28072,Q08209,P61088,Q14997 10 Apc c mediated degradation of cell cycle proteins 0.290010041464907 0.3149742484296012 0.7527812062215675 1.0 1.0 50 P55036,O00487,P49721,Q16763,P14635 5 Transcriptional regulation by runx3 0.2889772985883607 0.3119164211657872 0.755104042392085 1.0 1.0 42 P55036,O75832,O00487,P49721,Q13951 5 Maturation of sars cov 2 spike protein 0.3874464894104308 0.3104883900463648 0.7561895869502164 1.0 1.0 9 P04843,P04844 2 Dna replication initiation 0.4229756965336069 0.3092008876664894 0.7571687187062988 1.0 1.0 6 Q14181,P49642,Q07864 3 Activation of the pre replicative complex 0.3202790679227678 0.3052952613101876 0.7601412847010611 1.0 1.0 19 P35244 1 Budding and maturation of hiv virion 0.4206060406557869 0.3023713230408572 0.7623690131181251 1.0 1.0 6 Q8WUX9 1 Nuclear events stimulated by alk signaling in cancer 0.3523896976090227 0.3010467972638671 0.7633788096870282 1.0 1.0 12 P51608,P40763 2 Mapk family signaling cascades 0.2632004187827508 0.293922229328267 0.7688173314294842 1.0 1.0 88 P55036,O75832,P20936,O75608,O00487,P49356,P49721,P28072,Q14738,Q9NWH9,P07196,Q96S59,P04792,Q9UQ13,P36507,P35609,P62333,Q14997 18 Transport of vitamins nucleosides and related molecules 0.4046164354855612 0.2928354308874272 0.7696479448397293 1.0 1.0 7 Q8TB61,Q99808 2 Semaphorin interactions 0.3243556155980923 0.2873539294845648 0.7738413331835838 1.0 1.0 15 Q9NWH9 1 Rhod gtpase cycle 0.3061976268077885 0.2740685947714726 0.7840319078427445 1.0 1.0 25 O15173,Q02952,Q9NSV4,Q8NHP6,Q68EM7,Q9H0H5,Q9BX68,O60610,P42166,Q9P2R3,Q5JTV8 11 Rho gtpases activate pkns 0.3175098371783442 0.2726998229437942 0.7850839708169302 1.0 1.0 17 Q9Y3B8,Q04917,P62805 3 Cdt1 association with the cdc6 orc origin complex 0.2816402409845506 0.2717346538401297 0.7858260536129857 1.0 1.0 39 P55036,O75832,O00487,P49721,P28072,Q9UBD5,Q14997 7 Dectin 1 mediated noncanonical nf kb signaling 0.2825421155099401 0.2688746141918039 0.7880261727710036 1.0 1.0 42 P55036,O75832,O00487,P49721,P28072,Q8TBC4,Q14997 7 Tnfr2 non canonical nf kb pathway 0.2825421155099399 0.268874614191803 0.7880261727710043 1.0 1.0 42 P55036,O75832,O00487,P49721,P28072,Q8TBC4,Q14997 7 Nicotinate metabolism 0.5084788345188804 0.2635525855938868 0.7921246981957253 1.0 1.0 4 P43490,Q9BQG2 2 Rhoa gtpase cycle 0.280041947494466 0.2552792530016695 0.7985074229216995 1.0 1.0 41 Q8NBN3,O15173,P14923,P30519,Q9NQW6,P52565,Q9NSV4,Q9H0H5,O00161,Q96HY6,O15498 11 Diseases of immune system 0.4263537906137111 0.2481635314295574 0.8040078815937239 1.0 1.0 2 P09429 1 Regulated necrosis 0.3110165454808744 0.2463488752844159 0.8054121784249959 1.0 1.0 17 Q8WUX9,O15294,Q9UNE7,P42574 4 Telomere c strand synthesis initiation 0.4085074566478838 0.2461650196288786 0.8055544927792104 1.0 1.0 5 Q14181,P49642,P09884 3 Degradation of cysteine and homocysteine 0.5003571370577965 0.2453139675120226 0.8062133376054494 1.0 1.0 4 Q96SZ5 1 N glycan trimming in the er and calnexin calreticulin cycle 0.3126146462155315 0.241456303147934 0.8092014796822926 1.0 1.0 15 Q9BUN8,Q9NYU2 2 Gap junction assembly 0.4062984298125314 0.240680915228948 0.8098024316623931 1.0 1.0 5 P68371,P04350 2 Transport of connexons to the plasma membrane 0.4062984298125314 0.240680915228948 0.8098024316623931 1.0 1.0 5 P68371,P04350 2 Rhoh gtpase cycle 0.3122875663781098 0.24022601191397 0.8101550494116705 1.0 1.0 15 O75116,P14923,P02786,P52565,Q6IAA8,Q15758 6 Uptake and function of diphtheria toxin 0.4923138104048294 0.2279579690581652 0.8196789160851385 1.0 1.0 4 Q16881,P08238 2 Fbxw7 mutants and notch1 in cancer 0.4176895306859151 0.2254913341558531 0.8215970661373149 1.0 1.0 2 Q13616 1 Regulation of bach1 activity 0.4176895306859151 0.2254913341558531 0.8215970661373149 1.0 1.0 2 Q13616 1 Degradation of dvl 0.271996400260584 0.2156612920927147 0.8292517756061608 1.0 1.0 38 P55036,O75832,O00487,P49721,P28072,Q14997 6 Abc transporter disorders 0.273350870267564 0.2110013479006844 0.832886219562081 1.0 1.0 42 P55036,O75832,O00487,P49721,Q9BUN8 5 Defective cftr causes cystic fibrosis 0.2733508702675639 0.2110013479006836 0.8328862195620816 1.0 1.0 42 P55036,O75832,O00487,P49721,Q9BUN8 5 Asymmetric localization of pcp proteins 0.271184833548044 0.2108538047287458 0.8330013521323456 1.0 1.0 38 P55036,O75832,O00487,P49721,P28072,Q14997 6 Cross presentation of soluble exogenous antigens endosomes 0.2732819209502541 0.2047730121690532 0.8377494733636561 1.0 1.0 37 P55036,O75832,O00487,P49721,P28072,Q14997 6 Degradation of axin 0.2732819209502541 0.2047730121690532 0.8377494733636561 1.0 1.0 37 P55036,O75832,O00487,P49721,P28072,Q14997 6 M phase 0.2477671711266579 0.2025122556607031 0.8395162782697014 1.0 1.0 171 P68371,P04350,O75832,Q02241,P62820,Q14738,Q06323,P14635,Q14997,Q53HL2,P62805,P49721,Q99661,P19784,O43237,P30260,Q9BZD4,Q2NKX8,Q5SRE5,Q9NTI5,P55036,Q9HBM1,O00487,P50748,O43768,Q16763,P28072,Q99986,Q9BPX3,P62333,Q8WUX9,P42695,Q7Z5K2,O43633,Q9BSJ2,Q96CW5,O00139,Q86XL3 38 Uptake and actions of bacterial toxins 0.3579769213184767 0.1982194959876453 0.842873334522811 1.0 1.0 8 Q02750,Q16881,P36507,P08238 4 Transferrin endocytosis and recycling 0.3312006817075494 0.1972599988193962 0.8436240805918538 1.0 1.0 11 P21281,P21283,P02786 3 Alk mutants bind tkis 0.3767172812725896 0.1895227439236787 0.8496831310338577 1.0 1.0 6 Q9HC35,O43815,Q00610,Q9NR09,P10644 5 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.3742947936461769 0.184098208981835 0.8539364114922865 1.0 1.0 6 Q14181,P49642,P49643,P09884 4 Apoptotic execution phase 0.2839853817585662 0.1829006201177448 0.8548759963214336 1.0 1.0 28 P10412,P16403,P07305,P42574,P15924 5 G2 m dna damage checkpoint 0.2796933643591699 0.180120766457107 0.8570577599558629 1.0 1.0 32 P35244,P14635 2 Gene silencing by rna 0.2680662136576169 0.1752053529105575 0.8609182783782159 1.0 1.0 44 P19388 1 Intra golgi traffic 0.3404511894412754 0.1749576070431078 0.8611129443988137 1.0 1.0 9 O95721,O00461 2 Potential therapeutics for sars 0.2804135246456756 0.1725488955068604 0.8630060246955 1.0 1.0 30 O94973,P49356 2 Signaling by the b cell receptor bcr 0.2680726143904533 0.1707584699251667 0.8644136855679045 1.0 1.0 47 P55036,O75832,O43318,O00487,P49721,Q08209 6 Traf6 mediated nf kb activation 0.4599326181319336 0.1654831447626396 0.8685637154607104 1.0 1.0 4 Q14258 1 Rho gtpases activate formins 0.2666441553502822 0.16138662616574 0.8717888993746679 1.0 1.0 52 P68371,Q9HBM1,Q53HL2,P50748,Q9NSV4,Q9BZD4,O43237,Q2NKX8,O00139 9 Dna replication pre initiation 0.2631310095154374 0.1607701617955913 0.8722744269260567 1.0 1.0 61 P55036,O75832,O00487,P49721,P28072,P35244,Q07864,Q9UBD5,P52294,Q14997 10 Scf skp2 mediated degradation of p27 p21 0.2633826512953422 0.1593747202159444 0.8733736546728104 1.0 1.0 40 P55036,O75832,O00487,P49721 4 Stabilization of p53 0.262846473684005 0.1564494672211621 0.8756787479798689 1.0 1.0 40 P55036,O75832,O00487,P49721,P28072,P62333,Q06323,Q14997 8 Dna replication 0.2487490206664948 0.1520986614057433 0.8791091199685463 1.0 1.0 84 P18858,P55036,O75832,O00487,Q9BRX5,P49721,Q14997,Q16763,P28072,P35244,Q9UBD5,P52294,Q07864 13 Metabolism of polyamines 0.2613473818591743 0.1517517479716963 0.8793827407908505 1.0 1.0 39 P55036,O75832,O00487,P49721,P28072,Q14997 6 Assembly and cell surface presentation of nmda receptors 0.3183398651837327 0.1412595495924999 0.8876649038707769 1.0 1.0 10 P68371,P04350,P35609,P07196 4 Synthesis of ketone bodies 0.4569470934319683 0.137051959747453 0.8909897246190253 1.0 1.0 3 P35610 1 Ketone body metabolism 0.4569470934319683 0.137051959747453 0.8909897246190253 1.0 1.0 3 P35610 1 Tp53 regulates transcription of genes involved in cytochrome c release 0.3758122743682252 0.1347137478754213 0.8928382030460225 1.0 1.0 2 Q07812 1 Pi5p regulates tp53 acetylation 0.3758122743682252 0.1347137478754213 0.8928382030460225 1.0 1.0 2 Q13526 1 Nervous system development 0.2508582307855885 0.1334998760143148 0.8937980623195343 1.0 1.0 201 P68371,P04350,Q00169,Q8TEY7,Q01518,O75832,P62906,P18077,P11940,P36507,Q16850,P62249,P62910,Q9Y3U8,Q06323,P62753,P62899,P62424,P50570,Q14997,P62841,O15145,O95239,P49721,P32969,P19784,P62263,P62081,P35241,P15880,Q92542,P26038,P30050,P62861,Q02750,P62241,P55036,P20936,P35268,O00487,P62244,P62269,Q16539,P39019,P28072,P62750,Q04637,Q9NWH9,P61247,Q15369,P08865,O43242,O94973,P05388,P62333,P08238,O75116,Q14195,P61353,P42766,Q9Y490,P18124,Q96S59,Q13885,P05387,P17612,Q13617 67 Hdacs deacetylate histones 0.3134827916889274 0.1302518612122804 0.8963671647078106 1.0 1.0 10 Q86YP4 1 Caspase mediated cleavage of cytoskeletal proteins 0.3365825789521353 0.1279167886273687 0.8982148247911865 1.0 1.0 7 P42574 1 Synthesis of diphthamide eef2 0.3714801444043262 0.1271256005239646 0.898840989555481 1.0 1.0 2 Q9BQC3 1 Uch proteinases 0.2588335144404655 0.1243063980472364 0.901072681685597 1.0 1.0 44 P55036,O75832,O00487,P49721,P28072,O15294,Q14997 7 Pten regulation 0.2572186751889894 0.1234926776668473 0.9017169722854944 1.0 1.0 61 P55036,O75832,O00487,P31749,P49721,P28072,P31751,Q6IAA8,Q86YP4,Q9UNE7 10 Synthesis of dna 0.2493933871751248 0.122157308554673 0.9027744360085024 1.0 1.0 79 P18858,P55036,O75832,O00487,Q9BRX5,P49721,Q16763,P28072,P35244,Q9UBD5,Q07864 11 Degradation of gli1 by the proteasome 0.2563730598439753 0.1193600849338786 0.9049900827775386 1.0 1.0 41 P55036,O75832,O00487,P49721,P28072,Q14997 6 Rho gtpases activate nadph oxidases 0.3444163353812708 0.1150089758839493 0.908438007529468 1.0 1.0 5 Q16539,P63000,P27361,Q13526 4 G alpha i signalling events 0.2692319153930856 0.1138319600434804 0.909371002802256 1.0 1.0 20 Q08209,P04899 2 Membrane trafficking 0.2508046603097769 0.1130277015501702 0.9100085932744252 1.0 1.0 209 P68371,Q02241,Q15102,P68402,O00461,Q8IWJ2,Q92783,Q12756,Q99661,O43237,P20645,Q5JRA6,Q96A65,O15498,Q96KP1,Q01968,Q04917,P31749,Q14671,Q10567,P31751,Q7Z392,Q9H0H5,Q8NC96,P53365,P60520,O95721,O94973,P20339,Q9Y3P9,O15260,Q8WUX9,O43633,Q14789,Q9NVZ3,Q8TAG9,Q8IUR0,O00161,O00139,Q9Y3B8,P54619 41 Miro gtpase cycle 0.4254491071364238 0.1123930678096875 0.9105117515889702 1.0 1.0 4 O95140 1 Rhot1 gtpase cycle 0.3606498194945783 0.1096110053037523 0.9127178822832906 1.0 1.0 2 P52306 1 Inositol phosphate metabolism 0.4198663286796295 0.1051024361554053 0.9162945262403506 1.0 1.0 4 Q01968 1 Peroxisomal lipid metabolism 0.3003045984828557 0.1028353853089694 0.9180936207147656 1.0 1.0 10 P51648,O15254 2 Map3k8 tpl2 dependent mapk1 3 activation 0.417991329479777 0.1027340427575649 0.9181740543690816 1.0 1.0 4 Q13616,Q02750,O15111 3 Ros and rns production in phagocytes 0.306369273958484 0.1017982556647876 0.9189168102367492 1.0 1.0 9 P21281,P21283 2 Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.4265077645359301 0.0967933519583609 0.9228905035137492 1.0 1.0 3 Q7Z434,Q14258 2 Tcr signaling 0.2545560256223413 0.0958451275677216 0.9236435756980552 1.0 1.0 48 P55036,O75832,O43318,O00487,P49721,P28072 6 Cellular response to hypoxia 0.2505964005948339 0.094287658006052 0.9248806537214302 1.0 1.0 40 P55036,O75832,O00487,P49721,P28072,Q15369,P62333,Q06323,Q14997 9 G1 s dna damage checkpoints 0.2511448836932289 0.0937796955903065 0.9252841611632056 1.0 1.0 41 P55036,O75832,O00487,P49721,P28072,P62333,Q06323,Q14997 8 Pcp ce pathway 0.2536066443719645 0.0923819222200521 0.9263946019801332 1.0 1.0 47 P55036,O75832,O00487,P49721,O94973 5 Signalling to erks 0.3009038835682777 0.0921354279802951 0.926590440695239 1.0 1.0 9 Q16539,P36507 2 Protein ubiquitination 0.2620033815441125 0.0919654321334883 0.9267255043266976 1.0 1.0 24 Q9BUN8,Q16763,Q14527 3 Erks are inactivated 0.3126622273504105 0.0878066418374112 0.9300303587353228 1.0 1.0 7 Q8IV63 1 Regulation of pyruvate dehydrogenase pdh complex 0.3203181489515438 0.0866614560731387 0.9309406147054824 1.0 1.0 6 P11177,P10515,P09622,Q15120,O43708 5 Sars cov infections 0.2520833120320783 0.0849200690472924 0.9323249366256604 1.0 1.0 47 P04843,Q8WUX9,O75116,P49356,Q86YP4,P04844,O94973 7 Map2k and mapk activation 0.2840583657508905 0.0848643784039031 0.9323692115047596 1.0 1.0 11 Q9Y490,P36507 2 Signaling by moderate kinase activity braf mutants 0.2840583657508905 0.0848643784039031 0.9323692115047596 1.0 1.0 11 Q9Y490,P36507 2 Reproduction 0.2585723891735128 0.0834742389936838 0.9334744601946556 1.0 1.0 22 O94901,P35244 2 Meiosis 0.2585723891735128 0.0834742389936838 0.9334744601946556 1.0 1.0 22 O94901,P35244 2 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.399827917189079 0.0818386091719511 0.9347750533537982 1.0 1.0 4 Q14738 1 Diseases associated with n glycosylation of proteins 0.4120621162874647 0.0812984827314349 0.935204580602686 1.0 1.0 3 Q9BT22,O75340 2 Regulation of pten gene transcription 0.2600652883569041 0.0812683932232383 0.9352285093773304 1.0 1.0 15 P04637,Q8WXI9,Q15022,Q13547,O94776,Q13330,O60341,Q92769,P27361,Q6IAA8,Q86YP4,P42345,P28482,Q9Y2Q5 14 Mapk6 mapk4 signaling 0.2515165701218955 0.0808409761079303 0.9355684204716423 1.0 1.0 48 P55036,O75832,O00487,P49721,P04792 5 Degradation of beta catenin by the destruction complex 0.2512057480268493 0.080691728657906 0.9356871149415192 1.0 1.0 47 P55036,O75832,O00487,P56545,P49721,P28072,Q14738,P62333,Q14997 9 Tp53 regulates transcription of cell death genes 0.3130874909616712 0.0770113037731237 0.9386145525645084 1.0 1.0 6 P04637,P49327,P55212,P42575,Q07812 5 Signaling by alk in cancer 0.2541128666801893 0.0759725859736123 0.9394409083718545 1.0 1.0 33 P26038,P49589,Q8IWJ2,P51608 4 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.3120731488701149 0.0757198145750882 0.9396420114973758 1.0 1.0 6 Q15067 1 Hedgehog on state 0.2476789296868017 0.0749222531069135 0.9402765708973172 1.0 1.0 42 P55036,O75832,O00487,P49721,P28072,Q14997 6 Insulin receptor recycling 0.2840089597008615 0.07386675344242 0.9411164104623246 1.0 1.0 10 P21281,P21283 2 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.2570289660774077 0.0738605408764424 0.9411213538691768 1.0 1.0 17 P68371,P04350,Q13885,O15212 4 Intraflagellar transport 0.2802279566573373 0.0679125593287417 0.945855240938108 1.0 1.0 10 P68371,P04350,A0AVF1 3 Signaling by insulin receptor 0.2538277732843547 0.0675238072160413 0.9461647098568522 1.0 1.0 15 P21281 1 Hiv life cycle 0.244614133232924 0.0644027730374874 0.9486495220483082 1.0 1.0 67 P18858,Q14241,P17096,P19388 4 Cell cycle mitotic 0.2489353330601813 0.0614111092396667 0.951031805166112 1.0 1.0 225 P68371,P04350,O75832,Q02241,P62820,Q14738,Q9UBD5,Q9Y248,Q06323,P14635,Q14997,P18858,Q53HL2,P62805,P49721,Q99661,P19784,O43237,P30260,Q9BZD4,Q2NKX8,P35244,Q9BVL2,Q5SRE5,Q9NTI5,P55036,Q9HBM1,O00487,P42771,P31749,P50748,O43768,P16104,Q16763,P28072,P31751,Q99640,Q99986,Q9BPX3,P62333,Q07864,Q8WUX9,P42695,Q7Z5K2,O43633,Q9BRX5,P00374,Q9BSJ2,Q96CW5,O00139,Q86XL3 51 Copi independent golgi to er retrograde traffic 0.2503176997007098 0.0573739750395796 0.9542472937539104 1.0 1.0 27 P68371,P04350,Q9H2M9,Q9UJW0,P68402,Q15102,O43237,Q13885 8 Cell cycle checkpoints 0.2460169844898237 0.0555079565584802 0.9557337913078308 1.0 1.0 127 O75832,Q9UBD5,P14635,Q14997,Q53HL2,P62805,P49721,O43237,Q9BZD4,Q2NKX8,P35244,P55036,Q9HBM1,O00487,P50748,Q16763,P28072,Q99640,P61088,O00139,Q9Y3B8 21 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.2586533340049338 0.0521990384234766 0.95837009911773 1.0 1.0 12 P63218 1 Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 0.376309136872517 0.0520680082112191 0.9584745041231616 1.0 1.0 3 P46087,P10809 2 Tp53 regulates transcription of caspase activators and caspases 0.3759479956663009 0.0518336100573945 0.9586612745844764 1.0 1.0 3 P55212,P42575 2 Gamma carboxylation hypusine formation and arylsulfatase activation 0.2731197876893737 0.0516260836695412 0.9588266352862038 1.0 1.0 9 Q9BU89,P49366,O43681,P38435,Q9BQC3 5 Beta oxidation of hexanoyl coa to butanoyl coa 0.3622454364830925 0.0496395454625095 0.9604096327390328 1.0 1.0 4 P55084 1 Beta oxidation of lauroyl coa to decanoyl coa coa 0.3622454364830925 0.0496395454625095 0.9604096327390328 1.0 1.0 4 P55084 1 Slbp dependent processing of replication dependent histone pre mrnas 0.3701697363669162 0.0482347686738636 0.9615291410306102 1.0 1.0 3 P62304,P62318 2 Platelet homeostasis 0.2660404189400996 0.0480606686412687 0.9616678918389778 1.0 1.0 10 Q16539,P63218 2 Dna methylation 0.3578831240926597 0.0467786908648314 0.9626896126641724 1.0 1.0 4 P62805 1 Scavenging by class f receptors 0.3572976878612746 0.0464074736226936 0.9629854798430252 1.0 1.0 4 P27797,Q92598,P07900 3 Protein folding 0.2395466675649118 0.0444095692410784 0.9645779340243364 1.0 1.0 37 P68371,P04350,P61962,P19784,Q13885,P40763,Q99426,O95302,P63218,O15212 10 Hiv infection 0.2448760120013293 0.0420706873266817 0.9664423475987196 1.0 1.0 122 P18858,P55036,Q8WUX9,O00487,P19388,P49721,Q10567,Q14241,O94973,P17096 10 Response to elevated platelet cytosolic ca2 0.2437644395063476 0.0368375197320648 0.9706145579192632 1.0 1.0 30 P55145,O15439 2 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.2711462282523845 0.0362472493588911 0.9710852111825156 1.0 1.0 5 Q99808 1 Sars cov 1 infection 0.2578138330425916 0.0351036130226081 0.9719971204140287 1.0 1.0 9 Q8WUX9 1 Reduction of cytosolic ca levels 0.3387504514265066 0.0331965132261682 0.9735178786340926 1.0 1.0 3 P16615,P20020 2 Platelet calcium homeostasis 0.3387504514265066 0.0331965132261682 0.9735178786340926 1.0 1.0 3 P16615,P20020 2 Beta catenin phosphorylation cascade 0.2612246407793667 0.0305654911205691 0.9756160633797182 1.0 1.0 5 Q14738,P30153,P35222 3 Disassembly of the destruction complex and recruitment of axin to the membrane 0.2612246407793667 0.0305654911205691 0.9756160633797182 1.0 1.0 5 Q14738,P30153,P35222 3 Signaling by ctnnb1 phospho site mutants 0.2612246407793667 0.0305654911205691 0.9756160633797182 1.0 1.0 5 Q14738,P30153,P35222 3 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.2377007898269798 0.0281761517898649 0.9775216577859408 1.0 1.0 44 P55036,O75832,O00487,P49721,P28072,Q16763,P62333,Q06323,Q14997 9 Sars cov 2 infection 0.2338012583581664 0.0270133694553566 0.9784490706398552 1.0 1.0 17 P04843,Q8WUX9,P04844 3 Hdms demethylate histones 0.2452691510587693 0.0233457674254239 0.9813744645231604 1.0 1.0 5 O60341,P62805 2 Intracellular signaling by second messengers 0.2343828337521619 0.023161123284568 0.981521749406658 1.0 1.0 79 P55036,O75832,O00487,P31749,P84095,P49721,P28072,Q14738,Q9NWH9,P31751,Q96B36,Q9UNE7,Q86YP4,Q6IAA8,P62333,Q06323,Q14997 17 Protein methylation 0.2487346348517687 0.0222110705201434 0.9822795867718456 1.0 1.0 6 P55072,P11142,P15880,P13639,P38117 5 Orc1 removal from chromatin 0.2380234877568566 0.0218368023003729 0.9825781371889732 1.0 1.0 48 P55036,O75832,O00487,P49721,P28072,Q9UBD5,Q14997 7 Rho gtpases activate iqgaps 0.2362616179404335 0.0181680825075814 0.9855047649015154 1.0 1.0 10 P68371,P04350 2 Sumoylation of transcription factors 0.2308526011560688 0.0139090523461309 0.9889025397011016 1.0 1.0 4 P04637,Q13330,P42771 3 Regulation of mrna stability by proteins that bind au rich elements 0.2350634509637366 0.01178060258598 0.9906006564910792 1.0 1.0 63 P55036,O75832,Q06265,O00487,P31749,P49721,P04792,P11940 8 Glycogen metabolism 0.221287563453989 0.0096387184747055 0.992309534423606 1.0 1.0 9 Q16851 1 Intra golgi and retrograde golgi to er traffic 0.2276414835486331 0.0030371004084194 0.997576748199852 1.0 1.0 84 P68371,P04350,Q02241,P62820,Q15102,P68402,O00461,Q8IWJ2,Q12756,Q99661,O43237,P20645,O15498,Q9H0H5,P53365,O95721,O15260,P61923,O00139 19 G2 m checkpoints 0.2293670717927085 0.0011295036347045 0.9990987866801232 1.0 1.0 81 P55036,O75832,O00487,Q04917,P62805,P49721,P28072,Q99640,P35244,P61088,Q9UBD5,Q9Y3B8,P14635,Q14997 14