diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..27c0dd112f058bba8ea7fc05eae5d9973e6e0f46 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1ceac184f2f612366885ffe759fb09b1962df49733945addaf44ecf50494d0de +size 56742 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9e007801930fcb51bde16714be9a4c4ad6deea07 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 49, + "title": "Average number of proteins per term", + "value": 2.3469387755102042 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..adfe1756a12bead362fdbe64ad43c504eb088f6d --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9346c5518a9bd031aedcc87d29438ef569d70905 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cysteine peptidase, cysteine active site [IPR000169] 0.8474437627811842 1.2820143506052024 0.1998376121529286 0.999981981089498 0.4769094032566294 3 Q13867,P07384 2 +Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345] 0.7955846279640248 1.1047394381207898 0.2692725092269972 0.9999997891289948 0.4769094032566294 2 Q9NQ88 1 +Ubiquitin-conjugating enzyme, active site [IPR023313] 0.6087002755845314 1.0537762949002525 0.2919853489326303 0.9999999551182284 0.4769094032566294 5 Q16763,P61081,P68036 3 +Ubiquitin-activating enzyme E1, Cys active site [IPR033127] 0.7179485728670256 0.8080676286551404 0.4190516515212437 0.9999999999972284 0.5866723121297411 3 Q8TBC4 1 +Protein-tyrosine phosphatase, active site [IPR016130] 0.4238697810917491 0.0719791032578128 0.9426185378922658 1.0 0.9827299650366176 3 Q06124 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..016c4bc3b3e74a87296b43ec106397c11b261e08 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "BUB1", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK4", "CDK5", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAPK1", "MAPK3", "MDH1", "MDH2", "NEK9", "NME1", "NME2", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "VRK1", "VRK2"], "leading_proteins": ["BLMH", "CAPN1", "PTPN11", "TIGAR", "UBA3", "UBE2L3", "UBE2M", "UBE2S"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..28512a59a75e8b2bdec3c76a970e834f6564e2a2 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5eb55f18cbd8ae4604a3ffeb8ebe02fe7e142aa537b734d0fc855a9485ac1160 +size 139605 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..197b54c682fa553e8312e6924344c0e14218c8e7 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:806d2a5cc6c158d32d1967498ce0466cec5321e635367f75bbb4180dc7ebb07b +size 56029 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9f6fe202daf08e35d4a0b68bfd7b10e61546b2af --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 30, + "title": "Average number of proteins per term", + "value": 3.8 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e1da9b6d159c3d340510163c03298d3e88f2e895 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..134e539e6cbe72cb4e63ecb22e63820c5d72f70a --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.4752234072889514 1.7664185344853205 0.0773256578489507 0.9105761598724416 0.2635862313886972 31 O75340,P42566,Q9H4M9,P30626,P31949,P80303,P07384,Q9H223,P0DP25,Q02818,P17655,Q96AY3 12 +PPM-type phosphatase, divalent cation binding [IPR000222] 0.6439084219133345 0.5345883113070194 0.5929345680231339 0.9999999999980504 0.7177585905954152 2 O15355 1 +IQ motif, EF-hand binding site [IPR000048] 0.2739684100809657 0.0859236114748265 0.93152714167753 1.0 0.9636487672526174 8 P35579,Q15386 2 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ec1e956b19e46c746c31369c4d4663f6de6b4da5 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "ARG2", "AURKA", "BPNT1", "BUB1", "CALM3", "CALU", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK4", "CDK5", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "FKBP10", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "METAP2", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALM3", "CAPN1", "CAPN2", "EHD1", "EHD4", "EPS15", "FKBP10", "MYH9", "NUCB1", "NUCB2", "PDCD6", "PPM1G", "S100A11", "SRI", "UBE3C"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d87a456c859f7d763df70f2e8915263713ecf7 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e54da278d6e89cce9a5298b03244af0b83d9b6b9 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a9ae38d8f4bbd346f1be9d84175c7c54b9de9eae5f3eb7d3911c4d6fb75ee107 +size 191086 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..911eda7486e8b79fa008f3d7e66f6971a5387fa2 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Zinc finger, RING-type, conserved site [IPR017907]", "2": "14-3-3 protein, conserved site [IPR023409]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6fc4d5772b855825ee10e83435990d242baca26b --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0924f4d0010fd08583a60aee8d77dd7035ff06b0317015511ef9d9118e4f3ece +size 135408 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..adf12c5fd839ca60d9bdc835c0a195aae6bdb095 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:10a91d5c5a658ec85e60ddc11a08fb965df7eb779b5bc3bdfdaf710c2f50f0ae +size 136204 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..2caee2dea6b9da17a5682ae66a21b5f8f9d02e5e --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:db068a5db7b36c32c7024f42f4f0069be56269fc51770c82d3b2c947cc08e5dd +size 140483 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..d3923c42da8ace7076707634f54a98acd8887d6e --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2cc2d8c7d20efeecd49e7d5020677b34a17368ab1a68fc7a1b4b7af90e5737e9 +size 74391 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..08f7f0b0941feba3057d23921d25fa071a201b4b --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome beta-type subunit, conserved site [IPR016050] 6 8 2.4909064492114563 0.012741766435405 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.0 6.100773603616506e-07 1.9452211361664793e-08 4.636449106765799e-08 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..35e8c83140c5ba657873418066bbfe853ba2d8a8 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 259, + "title": "Average number of proteins per term", + "value": 2.444015444015444 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..aafd384098d0dc79163f9937b9ea4a7bd206bb19 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c725ffd0da04e5ac68f14f892f1b316fea10ca84 --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,30 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome beta-type subunit, conserved site [IPR016050] 0.8488782851045498 2.4909064492114563 0.012741766435405 0.963894948350024 0.110671026319446 8 Q99436,P49721,P28072,P28074,P28070,P20618 6 +Zinc finger, RING-type, conserved site [IPR017907] 0.6476375076091363 1.918458012456185 0.0550529612015786 0.999999572895334 0.2501529289685766 11 Q96T88,Q99590,P19474,Q5VTR2,Q14258 5 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.8683526959294796 1.85481373616322 0.0636228298182564 0.9999999596576212 0.2695591181755313 4 P48735 1 +DnaJ domain, conserved site [IPR018253] 0.5869211360006168 1.1933851426624589 0.2327185709747588 1.0 0.524122694630109 7 Q9NVH1,P31689,Q8WXX5,P25685 4 +Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326] 0.8074407195421114 1.1522506877109142 0.2492180742308076 1.0 0.5334502580642908 2 P29692 1 +Alpha-D-phosphohexomutase, conserved site [IPR016066] 0.803271983640085 1.1178739801179296 0.2636208193748128 1.0 0.5418872398260042 3 O95394,P36871 2 +Intermediate filament protein, conserved site [IPR018039] 0.6165219030606202 1.0866278689529068 0.2772013034240661 1.0 0.5461706479672697 5 P07197,Q03252 2 +RNA polymerase, beta subunit, conserved site [IPR007121] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5936690042520564 2 P30876 1 +FERM conserved site [IPR019747] 0.5406354240292106 0.9086390298603604 0.3635406973046047 1.0 0.5936690042520564 6 P15311,P35241,P26038,Q9Y490 4 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.7280524123739734 0.8439084222438878 0.3987205814519301 1.0 0.6183750335092808 3 Q9BXS5 1 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.7248569092395796 0.827399411138847 0.408010714241509 1.0 0.629016517788993 2 O15347 1 +Purine phosphorylase, family 2, conserved site [IPR018099] 0.6901062959934651 0.6973073102684049 0.4856104941424719 1.0 0.7026431172229064 2 Q13126 1 +Clathrin adaptor complex, small chain [IPR000804] 0.6638036809815916 0.6223373328631079 0.5337200778114601 1.0 0.7362026285065266 3 P53680,P61923 2 +Ubiquitin specific protease, conserved site [IPR018200] 0.4186083185729156 0.6211023687939287 0.534532270795316 1.0 0.7362026285065266 9 Q8TEY7,Q93008,P45974,Q86UV5 4 +Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.6529026982829174 0.5651564787813698 0.5719673357907868 1.0 0.7444197988432854 2 P06737 1 +Ubiquitin-activating enzyme E1, conserved site [IPR018074] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.7463772151258169 2 Q9UBT2 1 +Vinculin, conserved site [IPR000633] 0.6144726083401546 0.4390653190804529 0.6606142075748442 1.0 0.7777230898267484 2 P18206 1 +Mini-chromosome maintenance, conserved site [IPR018525] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7829092533433345 6 P33993,P33991 2 +Aldo/keto reductase, conserved site [IPR018170] 0.5977105478332051 0.388155323514135 0.6979010928689742 1.0 0.7993389816491331 2 P15121 1 +Ras GTPase-activating protein, conserved site [IPR023152] 0.5964840556009893 0.3845390578109857 0.7005789530283908 1.0 0.7993389816491331 2 Q13576 1 +DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.5948487326247014 0.3797412844268036 0.70413747116736 1.0 0.7998754606681853 2 P09884 1 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892] 0.348175472617991 0.3605004908736377 0.7184728896045871 1.0 0.8090629495982089 10 Q9H2H8 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.5457890433360684 0.2495909671132687 0.8029036847510862 1.0 0.8886839929509887 2 Q86Y82 1 +14-3-3 protein, conserved site [IPR023409] 0.3493038493038494 0.2013293122383055 0.8404410839381111 1.0 0.9184567119829992 6 P61981,Q04917,P31946,P27348,P63104 5 +Chromo domain, conserved site [IPR023779] 0.3328355073633764 0.1155041003876891 0.9080455705917287 1.0 0.975866401590281 5 O14646 1 +Cullin, conserved site [IPR016157] 0.3119115841178891 0.0814795418800377 0.9350605939902472 1.0 0.9807398146492974 5 Q13617,Q13616,Q93034,Q13620 4 +Sterol reductase, conserved site [IPR018083] 0.4206868356500519 0.0550650784793819 0.9560866172506092 1.0 0.9905057354716312 2 Q9UBM7 1 +Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628] 0.3912510220768675 0.0358916562908675 0.9713687488978712 1.0 0.9944051619152118 2 P11586 1 +Cyclic nucleotide-binding, conserved site [IPR018488] 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..62056be44d9fbcd6fd2479591483f4a012734150 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor, T-box, conserved site [IPR018186]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ATAD1", "ATP5C1", "ATP5O", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DYNLL1", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPDR1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GRWD1", "GSPT1", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPDH2", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGA", "MGST2", "MIF", "MPHOSPH8", "MPI", "MPP6", "MPST", "MRPL24", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFM", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KB", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", 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b/interpro_domain/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome component (PCI) domain [IPR000717] 10 17 2.5210294364282086 0.0117012062983405 6.577669902912621 18.740291262135923 0.0656253515457994 0.631967867263698 3.806137915628319 1.385790550244499 0.8221014102906427 0.3084914974953499 1.0 0.0655962799791107 0.0128531887811988 0.0885642472511138 5.26658545504972e-06 +Zinc finger, RING-type [IPR001841] 10 19 2.182344499981585 0.029084117086191 7.83252427184466 26.79368932038835 -0.1911762841470096 0.5719525680476609 4.456217477926311 6.9060026641091055 0.8588565107477053 0.2983783106382085 1.0 0.4161540317170912 0.3982975834822114 0.5586164149893487 0.7392570953639563 +SH3 domain [IPR001452] 6 19 2.067390589902613 0.038697364230763 8.412621359223301 34.599514563106794 -0.0873343944956481 0.6001758717014373 4.5941748598675405 5.423546269119778 0.8937759066152983 0.3136412847733088 1.0 0.3555035308737863 0.3078963612492302 0.4033384782528877 0.5318975327638309 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 1 5 2.001831515761753 0.0453028551724252 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 1.0 0.0347606010038453 0.0869978059975285 0.026979757634231 0.1038862441468568 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5555516c90a92dd35de62853625460212235e9a0 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 2188, + "title": "Average number of proteins per term", + "value": 2.053930530164534 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ac64d3470084343fcbbfd7a2b8d2dd58fb0be171 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d6ca7bcf89f39e03ffa393a2bceab0c56d0e4595 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,226 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome component (PCI) domain [IPR000717] 0.6923044176808762 2.5210294364282086 0.0117012062983405 0.9999999999934608 0.1132842450476514 17 Q99627,Q9UNS2,P60228,Q9UBW8,O43242,P48556,Q7L2H7,Q9Y262,Q15008,P61201 10 +Zinc finger, RING-type [IPR001841] 0.6025288430051055 2.182344499981585 0.029084117086191 1.0 0.1456202475619818 19 Q7Z6E9,Q9Y4X5,Q96T88,Q99590,Q12899,P19474,O75592,Q13263,Q5VTR2,Q14258 10 +SH3 domain [IPR001452] 0.5837002505434584 2.0673905899026135 0.038697364230763 1.0 0.1679957002716461 19 Q9UQB8,P62993,Q14847,Q9UDY2,Q9NZW5,Q5JRA6 6 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.9091041845590876 2.0120858824111933 0.0442108845953002 1.0 0.1802296336359079 4 P55786,Q9UIQ6 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.9091041845590876 2.0120858824111933 0.0442108845953002 1.0 0.1802296336359079 4 P55786,Q9UIQ6 2 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8366507148229541 2.001831515761753 0.0453028551724252 1.0 0.1812269288879599 5 Q8WUJ1 1 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.8683526959294796 1.85481373616322 0.0636228298182564 1.0 0.2189756075346255 4 P48735 1 +ERAP1-like C-terminal domain [IPR024571] 0.9513491414554378 1.7343257747251806 0.0828602967187261 1.0 0.2508563699535979 2 Q9UIQ6 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.9390842191332788 1.6848698190843516 0.0920136906626023 1.0 0.2687929975564405 2 P98179 1 +PDZ domain [IPR001478] 0.6038906217984176 1.6027098677739675 0.1089987239149994 1.0 0.2914374020421614 10 Q9UDY2,Q96HC4,Q9NZW5,O14745,O00151 5 +Importin-beta, N-terminal domain [IPR001494] 0.5690899180639273 1.5929918907536982 0.1111620102437225 1.0 0.2955315655082198 13 Q8TEX9,Q92973,Q9HAV4,P55060,O95373,O43592,O00410,Q14974 8 +Zinc finger, RanBP2-type [IPR001876] 0.6450868101358734 1.58242297014039 0.1135530443669972 1.0 0.2984683983388186 8 Q01844,P35637 2 +Ubiquitin-associated domain [IPR015940] 0.613990621958888 1.5674080424591943 0.1170193453009851 1.0 0.3005144689184923 9 Q14157,Q9NRR5,Q04323 3 +SET domain [IPR001214] 0.6529442605346758 1.491603535042911 0.1358031109357713 1.0 0.3297860230049586 7 Q9H7B4 1 +Actin-depolymerising factor homology domain [IPR002108] 0.6732668002038551 1.4884645929137903 0.1366284130455495 1.0 0.3302721809342734 6 Q14019 1 +CTP synthase, N-terminal [IPR017456] 0.8834832379394956 1.4597579801031637 0.1443566007573626 1.0 0.3396260671581823 2 Q9NRF8 1 +CTP synthase GATase domain [IPR033828] 0.8834832379394956 1.4597579801031637 0.1443566007573626 1.0 0.3396260671581823 2 Q9NRF8 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.6442459201134678 1.4524966467458091 0.1463635608833993 1.0 0.3428730955169996 7 Q96AY3,Q02790 2 +EB1, C-terminal [IPR004953] 0.8806214227309916 1.448150301318927 0.1475750203293415 1.0 0.3442368278044769 2 Q15691 1 +Guanylate kinase-like domain [IPR008144] 0.8914580414873292 1.4461632326766154 0.1481314235569475 1.0 0.3445524673553016 3 Q9UDY2 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.8914580414873292 1.4461632326766154 0.1481314235569475 1.0 0.3445524673553016 3 Q9UDY2 1 +THIF-type NAD/FAD binding fold [IPR000594] 0.6612601058036002 1.436099658132927 0.1509739853744607 1.0 0.3480833298201475 6 Q8TBC4,A0AVT1 2 +SH2 domain [IPR000980] 0.6335651956195654 1.4043739164037528 0.1602075338565283 1.0 0.3624964675057744 7 P40763,Q06124 2 +EH domain-containing protein, N-terminal [IPR031692] 0.8667211774325441 1.39177372247499 0.1639909296519377 1.0 0.3687689147774304 2 Q9H223 1 +Domain of unknown function DUF5600 [IPR040990] 0.8667211774325441 1.39177372247499 0.1639909296519377 1.0 0.3687689147774304 2 Q9H223 1 +Glutamine amidotransferase [IPR017926] 0.7496862004166885 1.3863476535481003 0.1656407722815227 1.0 0.3720965192525377 4 Q9NRF8 1 +EH domain [IPR000261] 0.7487725040916462 1.382699643302858 0.1667569813345486 1.0 0.3726648643887761 4 P42566,Q9H223,Q9H4M9 3 +CSN8/PSMD8/EIF3K [IPR033464] 0.8727523649088189 1.3763997945923216 0.1686978915499881 1.0 0.3735941161046296 3 Q99627 1 +Glutathione S-transferase, C-terminal [IPR004046] 0.5694408597699289 1.3494190660176055 0.1772024002047998 1.0 0.3833430325689478 9 P28161,O43324 2 +W2 domain [IPR003307] 0.619867685913019 1.342520881088294 0.1794271645439171 1.0 0.3849942905991584 7 P55010,Q04637,P78344,Q9Y6E2 4 +B-box-type zinc finger [IPR000315] 0.6724503442840303 1.3224058683574045 0.1860330357884159 1.0 0.3917615806593397 5 P19474,Q13263,Q12899 3 +Calpain subdomain III [IPR033883] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.3957006905020638 2 P07384 1 +Peptidase C2, calpain, large subunit, domain III [IPR022682] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.3957006905020638 2 P07384 1 +Peptidase C2, calpain, catalytic domain [IPR001300] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.3957006905020638 2 P07384 1 +Peptidase C2, calpain, domain III [IPR022683] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.3957006905020638 2 P07384 1 +Cold-shock (CSD) domain [IPR019844] 0.7274959083469605 1.2976880543937446 0.1943945501597317 1.0 0.4005040261294661 4 Q9Y2V2,P67809,P16989 3 +Cold shock domain [IPR011129] 0.7274959083469605 1.2976880543937446 0.1943945501597317 1.0 0.4005040261294661 4 Q9Y2V2,P67809,P16989 3 +Cold-shock protein, DNA-binding [IPR002059] 0.7274959083469605 1.2976880543937446 0.1943945501597317 1.0 0.4005040261294661 4 Q9Y2V2,P67809,P16989 3 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.8393295175797235 1.2808149801440254 0.2002586610600834 1.0 0.4083559649575605 2 Q9ULX6 1 +Methyltransferase type 11 [IPR013216] 0.8311529026982838 1.2477660356650415 0.2121167502098746 1.0 0.4219194995083687 2 Q8N6R0 1 +TOG domain [IPR034085] 0.6152226652561873 1.2343826508981468 0.2170603507075208 1.0 0.4263267929515759 6 Q8TEX9,O00410,Q86Y56 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.6111005853246152 1.2162863819201843 0.2238758473260642 1.0 0.4346409529276207 6 Q8IWA4,Q9H223,Q9H4M9 3 +Dynamin, N-terminal [IPR045063] 0.6111005853246152 1.2162863819201843 0.2238758473260642 1.0 0.4346409529276207 6 Q8IWA4,Q9H223,Q9H4M9 3 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.6987251167228623 1.1827229196472704 0.2369189776201092 1.0 0.4495912602192533 4 O60749,Q9Y5X3 2 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.5822127456745249 1.1720639308711935 0.2411713897827747 1.0 0.4537257100986338 7 O60568,O15460 2 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.5822127456745249 1.1720639308711935 0.2411713897827747 1.0 0.4537257100986338 7 O60568,O15460 2 +Helicase/UvrB, N-terminal [IPR006935] 0.811529026982834 1.1686766601081806 0.2425339289889647 1.0 0.4555759773738361 2 Q9UPY3 1 +FAD/NAD(P)-binding domain [IPR023753] 0.6359854303110252 1.1685839341887496 0.242571304223272 1.0 0.4555759773738361 5 O95831 1 +Rab-GTPase-TBC domain [IPR000195] 0.6913180644769201 1.1531666095698945 0.2488420058093616 1.0 0.462501396452084 4 Q8TC07 1 +Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038] 0.8074407195421114 1.1522506877109142 0.2492180742308076 1.0 0.462501396452084 2 P29692 1 +Elongation factor 1 beta central acidic region, eukaryote [IPR018940] 0.8074407195421114 1.1522506877109142 0.2492180742308076 1.0 0.462501396452084 2 P29692 1 +Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845] 0.8029435813573219 1.134206361948465 0.2567079960159011 1.0 0.4665092153511631 2 P36871 1 +Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846] 0.8029435813573219 1.134206361948465 0.2567079960159011 1.0 0.4665092153511631 2 P36871 1 +Alpha-D-phosphohexomutase, C-terminal [IPR005843] 0.8029435813573198 1.1342063619484557 0.2567079960159051 1.0 0.4665092153511631 2 O95394 1 +Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844] 0.803271983640085 1.1178739801179296 0.2636208193748128 1.0 0.4747344467424614 3 O95394,P36871 2 +Ubiquitin-like domain [IPR000626] 0.4867692719014069 1.1087568726769137 0.2675350799605873 1.0 0.4770715199297188 12 Q15813,Q86UV5,Q96T88,Q9NRR5,P54727,Q5TDH0 6 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.7978410027205249 1.0977964722639746 0.2722933722516059 1.0 0.4816312841443118 3 Q8TEY7 1 +Intermediate filament, rod domain [IPR039008] 0.6165219030606202 1.0866278689529068 0.2772013034240661 1.0 0.4841627620789092 5 P07197,Q03252 2 +SPRY-associated [IPR006574] 0.6744475260814684 1.085983400702439 0.2774863362188995 1.0 0.4841627620789092 4 P19474,Q14258 2 +Butyrophylin-like, SPRY domain [IPR003879] 0.6744475260814684 1.085983400702439 0.2774863362188995 1.0 0.4841627620789092 4 P19474,Q14258 2 +Mu homology domain [IPR028565] 0.6734203290978413 1.081900599909238 0.2792966982829592 1.0 0.4853292387204584 4 Q9BXS5 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7882256745707303 1.0753555698392367 0.2822155656704295 1.0 0.488518716524446 2 Q96AE4 1 +B-box, C-terminal [IPR003649] 0.7869991823385141 1.0704670346313594 0.2844091396696524 1.0 0.4898819773829166 2 Q13263 1 +La-type HTH domain [IPR006630] 0.6120004674035243 1.0676299513325618 0.2856874675392959 1.0 0.490262101157631 5 Q92615,Q6PKG0,Q4G0J3 3 +Intermediate filament head, DNA-binding domain [IPR006821] 0.7804578904333631 1.0444405365124214 0.2962816171688334 1.0 0.4936288512847104 2 P07197 1 +Immunoglobulin subtype [IPR003599] 0.5684563595036493 1.029438424111332 0.3032737010003341 1.0 0.499683767445779 6 Q8WX93,P35613 2 +Immunoglobulin subtype 2 [IPR003598] 0.5684563595036493 1.029438424111332 0.3032737010003341 1.0 0.499683767445779 6 Q8WX93,P35613 2 +Heat shock chaperonin-binding [IPR006636] 0.777505112474423 1.0229310872010249 0.3063404298135506 1.0 0.5020060190035627 3 Q9NRR5,P54727 2 +WW domain [IPR001202] 0.4891024038697105 1.0201309650325867 0.3076663529064096 1.0 0.5020060190035627 10 Q13526,Q6ZWJ1,O60828,Q96J02 4 +Thioredoxin-like fold [IPR012336] 0.7743254292722873 1.020115456204285 0.3076737072594961 1.0 0.5020060190035627 2 Q8NBF2 1 +Phosphoribosyltransferase domain [IPR000836] 0.565974858919827 1.0186122843536902 0.3083870699851059 1.0 0.5025526506216126 6 O60256,P07741 2 +DNA2/NAM7 helicase-like, C-terminal [IPR041679] 0.6572055380990843 1.0176083798812214 0.3088641033679746 1.0 0.5025526506216126 4 P51530 1 +Initiation factor eIF-4 gamma, MA3 [IPR003891] 0.6571992022557397 1.0175833232802047 0.3088760159516752 1.0 0.5025526506216126 4 Q04637 1 +UBX domain [IPR001012] 0.6000383212145082 1.0174750932782233 0.3089274749022253 1.0 0.5025526506216126 5 Q04323 1 +Domain of unknown function DUF4749 [IPR031847] 0.7722812755519244 1.0120243149423975 0.3115264277564771 1.0 0.5034119822239084 2 O00151 1 +Immunoglobulin-like domain [IPR007110] 0.4962687365976966 0.9895641308631652 0.3223872094095741 1.0 0.5111472566580784 9 Q8WX93,P35613 2 +S100/CaBP-9k-type, calcium binding, subdomain [IPR013787] 0.7653039137278435 0.9783032805897752 0.3279243478642621 1.0 0.5161859518899321 3 Q99584 1 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.5166428548152722 2 P43246 1 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.5166428548152722 2 P43246 1 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.5166428548152722 2 P43246 1 +DNA mismatch repair protein MutS, core [IPR007696] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.5166428548152722 2 P43246 1 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.5166428548152722 2 P43246 1 +GNAT domain [IPR000182] 0.5825920719274682 0.9446960422575552 0.3448140781728428 1.0 0.5317626681339306 5 Q86UY6 1 +Myosin tail [IPR002928] 0.7547015535568308 0.9428394549579492 0.3457630272581382 1.0 0.5323923319076752 2 P35579 1 +B30.2/SPRY domain [IPR001870] 0.4716915676333112 0.93223351978692 0.351215856024655 1.0 0.5368570738271938 10 P19474,Q14258,Q1KMD3,Q96S59 4 +SPRY domain [IPR003877] 0.4716915676333112 0.93223351978692 0.351215856024655 1.0 0.5368570738271938 10 P19474,Q14258,Q1KMD3,Q96S59 4 +MIT domain [IPR007330] 0.7521330089658471 0.9304312667401476 0.3521478361314871 1.0 0.5371623260721922 3 Q8N0X7 1 +Glutathione S-transferase, C-terminal-like [IPR010987] 0.471234246239552 0.9299346660659876 0.3524049128873119 1.0 0.5371623260721922 10 P28161 1 +RNA recognition motif domain [IPR000504] 0.2809471807682019 0.9151922970424178 0.3600906877893475 1.0 0.5433985371985623 110 Q96T37,P98175,Q8WXF0,P98179,Q14011,O43719,Q8IZ69,O14979,P23588,O15047,Q13247,P55884,Q5T8P6,P35637,Q13148,Q9NTZ6,Q8N684,Q01844,Q13310,O95104,Q92804 21 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5446282538836795 2 P30876 1 +RNA polymerase Rpb2, domain 3 [IPR007645] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5446282538836795 2 P30876 1 +RNA polymerase Rpb2, domain 7 [IPR007641] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5446282538836795 2 P30876 1 +RNA polymerase Rpb2, domain 2 [IPR007642] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5446282538836795 2 P30876 1 +RNA polymerase, beta subunit, protrusion [IPR007644] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.5446282538836795 2 P30876 1 +FERM domain [IPR000299] 0.5406354240292106 0.9086390298603604 0.3635406973046047 1.0 0.5448130450016953 6 P15311,P35241,P26038,Q9Y490 4 +HECT domain [IPR000569] 0.5182345476846468 0.8843648388177529 0.3764992972712981 1.0 0.5538525963958925 7 Q9ULT8,Q15386,Q96J02 3 +Zinc finger, FYVE-related [IPR017455] 0.7325153374233127 0.8598329192704266 0.389881150116111 1.0 0.5637383692277563 3 Q7Z3T8,Q15075 2 +FYVE zinc finger [IPR000306] 0.7325153374233127 0.8598329192704266 0.389881150116111 1.0 0.5637383692277563 3 Q7Z3T8,Q15075 2 +EF-hand, Ca insensitive [IPR014837] 0.614661877226333 0.8510236430803784 0.3947562192549898 1.0 0.5678675921958697 4 P12814,P35609 2 +Sorting nexin, N-terminal [IPR005329] 0.7301717089125148 0.8477401142335262 0.3965827208606312 1.0 0.5693720428104075 2 O60749 1 +Proteasome alpha-subunit, N-terminal domain [IPR000426] 0.5045153331071269 0.8237383082755078 0.4100882675955322 1.0 0.5830234759577807 7 P25787,P25789 2 +MOSC, N-terminal beta barrel [IPR005303] 0.7203597710547884 0.8102709840676091 0.4177844480513988 1.0 0.5893696791337593 2 Q969Z3 1 +Molybdenum cofactor sulfurase, C-terminal [IPR005302] 0.7203597710547884 0.8102709840676091 0.4177844480513988 1.0 0.5893696791337593 2 Q969Z3 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.4315509247144418 0.7931277308840728 0.4277034076659713 1.0 0.5983472224892235 11 Q9Y4C8,Q13310,Q14011,P38159 4 +C2 domain [IPR000008] 0.4945880641700749 0.7802702955145808 0.4352317932847089 1.0 0.6069389188699447 7 Q96J02 1 +ERM family, FERM domain C-lobe [IPR041789] 0.7092024539877205 0.777300069075937 0.4369817543066383 1.0 0.6072617682931444 3 P15311,P35241 2 +G-protein, beta subunit [IPR001632] 0.7052330335241257 0.7532646863946695 0.4512908749033393 1.0 0.6144385590697913 2 Q9NVX2 1 +26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.7048242027800538 0.7517378557281029 0.4522087202694558 1.0 0.6149364076753072 2 Q15008 1 +CAP Gly-rich domain [IPR000938] 0.6984744451989751 0.7399202992441405 0.4593483564661507 1.0 0.6168984203605193 3 Q14203 1 +Zinc finger, LIM-type [IPR001781] 0.532446031367622 0.7396369974196216 0.4595202860967418 1.0 0.6168984203605193 5 Q14847,O00151,Q15942 3 +BZW1/2, W2 domain [IPR043510] 0.7015535568274782 0.7395511264792843 0.4595724063928914 1.0 0.6168984203605193 2 Q9Y6E2 1 +MAGE homology domain [IPR002190] 0.696238757154543 0.7198565626414362 0.4716133148619692 1.0 0.6244484451717124 2 Q96MG7 1 +Coatomer subunit gamma, C-terminal [IPR032154] 0.6954210956663991 0.7168389450514846 0.4734734783088989 1.0 0.6244484451717124 2 Q9UBF2 1 +Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040] 0.6954210956663991 0.7168389450514846 0.4734734783088989 1.0 0.6244484451717124 2 Q9UBF2 1 +Cyclin-like [IPR013763] 0.6913327882256799 0.7018016710817814 0.4828028564997415 1.0 0.6311768806181988 2 P14635 1 +AP complex, mu/sigma subunit [IPR022775] 0.4913550009772574 0.699872168412765 0.4840071398496408 1.0 0.6311768806181988 6 Q92572,P53680,P61923,Q9Y2T2 4 +DnaJ domain [IPR001623] 0.4088628213019274 0.697507599113071 0.4854851854020339 1.0 0.6320736235477267 12 O75937,P31689,Q9NVH1,Q96KC8,P25685,Q8WXX5 6 +Nucleoside phosphorylase domain [IPR000845] 0.6901062959934651 0.6973073102684049 0.4856104941424719 1.0 0.6320736235477267 2 Q13126 1 +EF-hand domain [IPR002048] 0.3249608849627213 0.6919953872138792 0.4889402258008708 1.0 0.6350513436659432 37 O75340,P42566,Q9H4M9,P30626,P31949,P80303,P07384,Q9H223,P0DP25,Q02818,P17655,Q96AY3,P35609 13 +MIF4G-like, type 3 [IPR003890] 0.5182463848214139 0.6832486122873518 0.4944497596140644 1.0 0.6380507634361134 5 Q04637 1 +K Homology domain, type 1 [IPR004088] 0.3533749712788002 0.6743772891725824 0.500071477667958 1.0 0.6424876060701656 22 P51116,P61978,Q92945,Q15637,Q96AE4,Q07666 6 +PITH domain [IPR010400] 0.6815208503679532 0.6660733060570548 0.505364245788231 1.0 0.64555067815398 2 O43396 1 +HDGF-related, PWWP domain [IPR035496] 0.6768677518914825 0.6660079912950823 0.5054059925401133 1.0 0.64555067815398 3 P51858 1 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.669664758789867 0.6236344493133299 0.5328676812563753 1.0 0.6626540152037116 2 P51116 1 +FERM, C-terminal PH-like domain [IPR018980] 0.5023473828453893 0.6213355243001575 0.5343788847683593 1.0 0.6628236960732257 5 P15311,P35241,P26038 3 +FERM, N-terminal [IPR018979] 0.5023473828453893 0.6213355243001575 0.5343788847683593 1.0 0.6628236960732257 5 P15311,P35241,P26038 3 +DNA2/NAM7 helicase, helicase domain [IPR041677] 0.658457870114434 0.6047149323831774 0.5453684246546264 1.0 0.6703619603224872 3 P51530 1 +Exportin-2, central domain [IPR013713] 0.6564417177914055 0.598108158084645 0.5497677671398766 1.0 0.6730259860768049 3 P55060,O95373 2 +SNF2, N-terminal [IPR000330] 0.4024974400700597 0.5953648112401837 0.5515996418613907 1.0 0.6730259860768049 10 Q9H4L7 1 +Domain of unknown function DUF1747 [IPR013719] 0.659035159443996 0.5863315325041851 0.5576527449539399 1.0 0.677777184499802 2 Q08945 1 +Glucosamine/galactosamine-6-phosphate isomerase [IPR006148] 0.655355682747349 0.5735950053407596 0.5662418924294164 1.0 0.6845826742997765 2 P46926 1 +La protein, xRRM domain [IPR014886] 0.654129190515133 0.5693704278237927 0.5691047811542815 1.0 0.6871971639986578 2 Q4G0J3 1 +PurM-like, C-terminal domain [IPR010918] 0.6474437627811868 0.5688974935170711 0.5694257064591322 1.0 0.6872054306302158 3 O15067,P49903 2 +Phox homology [IPR001683] 0.4253054157998572 0.5671493975523416 0.570612684266715 1.0 0.6878790926587175 8 Q9Y2I1,O60749,Q9Y5X3 3 +Ubiquitin-activating enzyme, SCCH domain [IPR019572] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.6983007777226677 2 A0AVT1 1 +Ubiquitin-activating enzyme E1, FCCH domain [IPR032418] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.6983007777226677 2 A0AVT1 1 +Ubiquitin-activating enzyme E1, C-terminal [IPR018965] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.6983007777226677 2 A0AVT1 1 +Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.6983007777226677 2 A0AVT1 1 +PurM-like, N-terminal domain [IPR016188] 0.64717906786591 0.5456348050001556 0.585316994655076 1.0 0.6986762598501398 2 P49903 1 +Chaperone DnaJ, C-terminal [IPR002939] 0.6368098159509155 0.5349878378474493 0.5926582673419323 1.0 0.7047479831218194 3 P31689,P25685 2 +Septin-type guanine nucleotide-binding (G) domain [IPR030379] 0.4771515070131565 0.5264732940312052 0.5985594026011962 1.0 0.7079178231845499 5 Q92599,Q9NVA2,Q9UHD8 3 +CARG-binding factor, N-terminal [IPR012956] 0.6390024529844711 0.5181718893291948 0.604338345960377 1.0 0.7114203022557721 2 Q99729 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.7114203022557721 3 Q06323 1 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.7114203022557721 3 Q06323 1 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.6365494685200395 0.5100344136941491 0.6100273523314712 1.0 0.7121415014590613 2 P31689 1 +K Homology domain [IPR004087] 0.32673989587759 0.5058570868598189 0.6129569795738208 1.0 0.7145177790663398 22 P51116,P61978,Q92945,Q15637,Q96AE4,Q07666 6 +DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133] 0.6245415860342958 0.4967572534054122 0.6193602427799729 1.0 0.717395559133182 3 P09884 1 +DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134] 0.6245415860342958 0.4967572534054122 0.6193602427799729 1.0 0.717395559133182 3 P09884 1 +ENTH domain [IPR013809] 0.6287816843826726 0.4845878200265796 0.6279687552886632 1.0 0.7212328917038794 2 Q14677 1 +RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.6242845461978812 0.4700867983773216 0.6382930056729574 1.0 0.7285263935380443 2 Q9UPN9 1 +Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099] 0.614314928425366 0.465675900456363 0.6414475050726134 1.0 0.7311468365938436 3 P11908,O60256 2 +Amidohydrolase-related [IPR006680] 0.6222403924775216 0.463553239800315 0.642967862533721 1.0 0.7315723781714932 2 Q16555 1 +MCM domain [IPR001208] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7461339774955363 6 P33993,P33991 2 +MCM, AAA-lid domain [IPR041562] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7461339774955363 6 P33993,P33991 2 +MCM OB domain [IPR033762] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7461339774955363 6 P33993,P33991 2 +MCM N-terminal domain [IPR027925] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7461339774955363 6 P33993,P33991 2 +Ubiquitin-conjugating enzyme E2 [IPR000608] 0.4058254543712067 0.4179919915009613 0.6759529725515114 1.0 0.7515168211090991 7 Q16763,P61081,P68036 3 +Ras GTPase-activating domain [IPR001936] 0.5967280163599196 0.414051080071608 0.6788366984619709 1.0 0.7543396121050241 3 Q13576,Q14C86 2 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130] 0.3458117426517621 0.3870513024129179 0.6987182282450828 1.0 0.770562239617057 11 Q9H2H8 1 +RasGAP protein, C-terminal [IPR000593] 0.5964840556009893 0.3845390578109857 0.7005789530283908 1.0 0.7719866484049739 2 Q13576 1 +Calponin homology domain [IPR001715] 0.3071358523111759 0.3843548142778243 0.700715486166489 1.0 0.7719866484049739 21 P37802,Q15555,Q99439,P12814,Q15691,Q15149,P35609 7 +von Willebrand factor, type A [IPR002035] 0.4078685574397902 0.3795057840414436 0.7043123099279784 1.0 0.7751686791360245 6 Q96SY0,Q99829 2 +Zinc finger, C3HC4 RING-type [IPR018957] 0.5775051124744481 0.3605253373943357 0.7184543122824427 1.0 0.7903358648939088 3 Q5VTR2,O75150 2 +NUC153 [IPR012580] 0.5878986099754786 0.3596608001195895 0.7191008099125491 1.0 0.7906495337128931 2 Q9H501 1 +Thioesterase domain [IPR006683] 0.5870809484873346 0.3573319126263555 0.7208433420634157 1.0 0.792167369379585 2 O00154 1 +Small GTP-binding protein domain [IPR005225] 0.2856163406293693 0.3490143234767981 0.7270785563433955 1.0 0.797417484350551 34 P61586,P40616,Q9BW83 3 +FF domain [IPR002713] 0.5821749795584713 0.3435098405482151 0.7312149390341249 1.0 0.8015522477989305 2 O14776 1 +NADP-dependent oxidoreductase domain [IPR023210] 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.8192258278083452 3 P14550,P15121 2 +tRNA-binding domain [IPR002547] 0.5727718724448166 0.3177592292603681 0.7506675793039663 1.0 0.8204099218367025 2 P54577 1 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.5599182004090009 0.3144790997251899 0.7531571878677559 1.0 0.8224975284966697 3 Q13310,O95071 2 +Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553] 0.3214059874402682 0.2613215997307387 0.7938445109469381 1.0 0.8607194201942024 10 Q9Y678,O43747,Q9UBF2,Q10567 4 +Sterile alpha motif domain [IPR001660] 0.5482420278005002 0.2554228504148897 0.7983965238848556 1.0 0.8652261487172185 2 Q9Y6Y8 1 +AGC-kinase, C-terminal [IPR000961] 0.3937781416291458 0.2548288016699926 0.7988553289467819 1.0 0.8652828808038909 5 Q16513,Q15418,P17612,P51812 4 +Band 4.1 domain [IPR019749] 0.3560440641853062 0.250535215466677 0.8021734748303202 1.0 0.8669747186612221 7 P15311,P35241,P26038,Q9Y490 4 +FERM central domain [IPR019748] 0.3560440641853062 0.250535215466677 0.8021734748303202 1.0 0.8669747186612221 7 P15311,P35241,P26038,Q9Y490 4 +Syntaxin, N-terminal domain [IPR006011] 0.5457890433360684 0.2495909671132687 0.8029036847510862 1.0 0.8671042755357239 2 Q86Y82 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.5449713818479245 0.2476637054230012 0.8043946159763027 1.0 0.8678577020493837 2 O43390 1 +Ran binding domain [IPR000156] 0.4336991565032408 0.245978617680536 0.8056987846791466 1.0 0.868408345260085 4 Q9H6Z4 1 +Zinc finger, CCHC-type [IPR001878] 0.36308148483543 0.2386337207383476 0.8113896150363249 1.0 0.8741115104379512 6 Q15637 1 +Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.5367947669664859 0.2288548887329712 0.8189817036310161 1.0 0.880556249407697 2 Q2NL82 1 +AARP2CN [IPR012948] 0.5367947669664859 0.2288548887329712 0.8189817036310161 1.0 0.880556249407697 2 Q2NL82 1 +Bms1/Tsr1-type G domain [IPR030387] 0.5367947669664859 0.2288548887329712 0.8189817036310161 1.0 0.880556249407697 2 Q2NL82 1 +Ubiquitin specific protease domain [IPR028889] 0.3087821406551684 0.2194323650248051 0.826313260670257 1.0 0.886696132587799 10 Q8TEY7,Q93008,P45974,Q86UV5 4 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.3087821406551684 0.2194323650248051 0.826313260670257 1.0 0.886696132587799 10 Q8TEY7,Q93008,P45974,Q86UV5 4 +14-3-3 domain [IPR023410] 0.3493038493038494 0.2013293122383055 0.8404410839381111 1.0 0.9000905979718977 6 P61981,Q04917,P31946,P27348,P63104 5 +PWWP domain [IPR000313] 0.3337991656833126 0.1881404504285644 0.8507665523910537 1.0 0.9084808280290998 7 P51858,Q7Z4V5 2 +OBG-type guanine nucleotide-binding (G) domain [IPR031167] 0.4067077268634815 0.1832299986487535 0.8546175572853834 1.0 0.9121479099221556 4 Q9NTK5 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.4984054773592389 0.1786112668974278 0.8582429470529533 1.0 0.9151245458829737 3 P35579 1 +TGS [IPR004095] 0.3384777650816603 0.1742371754139535 0.861679070597487 1.0 0.917893771405697 6 P26639,Q9NTK5 2 +Zinc finger C2H2-type [IPR013087] 0.276441572719023 0.1580231239709492 0.8744385773541876 1.0 0.9264337517752884 15 Q92766,Q15075,O60678 3 +Zinc finger, UBP-type [IPR001607] 0.4716450742329398 0.1329098521624719 0.8942646751365342 1.0 0.941150124674717 3 Q8TEY7 1 +Zinc finger, CHHC-type [IPR012996] 0.470347648261765 0.1309081379012148 0.8958479769721486 1.0 0.9423631603918564 3 P52597,P31943 2 +Cullin, N-terminal [IPR001373] 0.3120393120393073 0.1167040382893022 0.9070945900547454 1.0 0.9505378175477888 6 Q13620,Q86Y37,Q13616,Q13617,Q93034 5 +Chromo domain [IPR023780] 0.3050305569275684 0.1035537809999998 0.9175234678070264 1.0 0.9580950300180232 6 O14646 1 +Ribosome receptor lysine/proline rich [IPR007794] 0.4660670482420397 0.1026416508437424 0.9182473848024656 1.0 0.9580950300180232 2 Q9P2E9 1 +Proteasomal ATPase OB C-terminal domain [IPR032501] 0.32173557101924 0.0965666930913256 0.9230705079021556 1.0 0.961751557757103 5 P17980,P62195,P62333,P62191 4 +OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365] 0.3202955381552277 0.0942574149867555 0.9249046771701304 1.0 0.9618305293004968 5 O43776 1 +Anticodon-binding [IPR004154] 0.3551554828150619 0.0917626874410512 0.9268865900486374 1.0 0.9619347376830896 4 P26639,P41250,P07814 3 +Fxr1, tudor domain [IPR041560] 0.4414214683030069 0.0913643467612163 0.9272030903901444 1.0 0.9619347376830896 3 P51116 1 +Agenet-like domain [IPR008395] 0.4414214683030069 0.0913643467612163 0.9272030903901444 1.0 0.9619347376830896 3 P51116 1 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.4414214683030069 0.0913643467612163 0.9272030903901444 1.0 0.9619347376830896 3 P51116 1 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.4414214683030069 0.0913643467612163 0.9272030903901444 1.0 0.9619347376830896 3 P51116 1 +Cullin protein, neddylation domain [IPR019559] 0.3119115841178891 0.0814795418800377 0.9350605939902472 1.0 0.9682501560107246 5 Q13617,Q13616,Q93034,Q13620 4 +Cullin homology domain [IPR016158] 0.3119115841178891 0.0814795418800377 0.9350605939902472 1.0 0.9682501560107246 5 Q13617,Q13616,Q93034,Q13620 4 +Tyrosine-specific protein phosphatases domain [IPR000387] 0.4238697810917491 0.0719791032578128 0.9426185378922658 1.0 0.9723947953362932 3 Q06124 1 +CDC48, N-terminal subdomain [IPR003338] 0.4317252657399945 0.0644653481746378 0.9485996978486856 1.0 0.9776430235011416 2 P46459 1 +CDC48, domain 2 [IPR004201] 0.4317252657399945 0.0644653481746378 0.9485996978486856 1.0 0.9776430235011416 2 P46459 1 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058] 0.4028629856850715 0.0530487131393637 0.9576930948544152 1.0 0.9819271281825024 3 Q5JPH6,P07814 2 +Myosin head, motor domain [IPR001609] 0.2702702702702654 0.0512317706912331 0.9591408357270096 1.0 0.9824907062596896 6 P35579,O43795,Q9UM54,P35580,O00159 5 +Pumilio homology domain [IPR033133] 0.409239574816036 0.046644620166004 0.9627964689620404 1.0 0.9845085048642108 2 Q14671 1 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059] 0.4026982829108824 0.0424003900396387 0.9661795174237456 1.0 0.9869038800078738 2 P07814 1 +Pleckstrin homology domain [IPR001849] 0.2297060527695356 0.0418647756374663 0.966606496735317 1.0 0.9869038800078738 13 Q96SU4,Q9NQW6 2 +Cadherin prodomain [IPR014868] 0.3945216680294452 0.0376369460274451 0.9699771501093724 1.0 0.9889608594777756 2 Q14574 1 +Cadherin, cytoplasmic domain [IPR000233] 0.3945216680294452 0.0376369460274451 0.9699771501093724 1.0 0.9889608594777756 2 Q14574 1 +SMCs flexible hinge [IPR010935] 0.2730249693000421 0.0364249348311476 0.9709435322487576 1.0 0.9894850715231868 5 Q9NTJ3,A6NHR9,Q9UQE7,O95347 4 +Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798] 0.380212591986928 0.0306311148911315 0.9755637276919142 1.0 0.9928062493906552 2 Q9UKA9 1 +High mobility group box domain [IPR009071] 0.2164281232815989 0.0242962971231324 0.9806162667283054 1.0 0.9938579758481516 9 P09429,Q08945,O15347 3 +Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152] 0.2411957411957366 0.022773854264139 0.9818306638892093 1.0 0.9940978679266956 6 O94973,Q9UJY4,P63010,Q10567,O43747 5 +Mad3/Bub1 homology region 1 [IPR013212] 0.3479149632052413 0.01998021022868 0.9840591593646424 1.0 0.995893358320924 2 O43683 1 +Cyclic nucleotide-binding domain [IPR000595] 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 0.9969144474450152 2 P10644 1 +cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 0.9969144474450152 2 P10644 1 +Nuclear transport factor 2, eukaryote [IPR018222] 0.323517382413083 0.0150270055013844 0.9880106355385624 1.0 0.9969144474450152 3 Q9UN86,Q13283 2 +Nuclear transport factor 2 domain [IPR002075] 0.323517382413083 0.0150270055013844 0.9880106355385624 1.0 0.9969144474450152 3 Q9UN86,Q13283 2 +LEM domain [IPR003887] 0.2283851011503143 0.009089447594104 0.9927477699594348 1.0 0.997154138631512 5 Q9Y2U8 1 +Threonyl/alanyl tRNA synthetase, SAD [IPR012947] 0.218993041342613 0.0058409177366184 0.9953396484160552 1.0 0.9980766043695368 5 P26639,Q9BTE6,Q9BW92,P49588 4 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b2b99fd636612791623989026556f53309687116 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABT1/ESF2, RNA recognition motif [IPR034353]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ASCH domain [IPR007374]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanine racemase, N-terminal [IPR001608]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arginine N-methyltransferase 2-like domain [IPR026480]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BDHCT [IPR012532]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-lactamase-related [IPR001466]", "Beta-trefoil DNA-binding domain [IPR015350]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bloom syndrome protein, BDHCT-box associated domain [IPR032439]", "Bloom syndrome protein, N-terminal domain [IPR032437]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "CP2 transcription factor [IPR007604]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Caspase recruitment domain [IPR031964]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic fatty-acid binding [IPR000463]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dienelactone hydrolase [IPR002925]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyl-phosphate beta-glucosyltransferase [IPR035518]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3699 [IPR022168]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drought induced 19 protein type, zinc-binding domain [IPR008598]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass [IPR042716]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein [IPR003382]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatitis delta antigen (HDAg) domain [IPR037517]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV [IPR000034]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MGA, conserved domain [IPR032060]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "MaoC-like dehydratase domain [IPR002539]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Mvd1, C-terminal [IPR041431]", "Myb domain [IPR017930]", "Myc-type, basic helix-loop-helix (bHLH) domain [IPR011598]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Neogenin, C-terminal [IPR010560]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Orc1-like, AAA ATPase domain [IPR041664]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain [IPR019601]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain [IPR001478]", "PH-BEACH domain [IPR023362]", "PHR [IPR012983]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKCBP1, PHD finger [IPR044075]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain [IPR039558]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM8, RNA recognition motif [IPR033744]", "RBP-J/Cbf11/Cbf12, DNA binding [IPR015351]", "RBP-Jkappa, IPT domain [IPR038007]", "RED-like, N-terminal [IPR012916]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "Rab-GTPase-TBC domain [IPR000195]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras-associating (RA) domain [IPR000159]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease H2 subunit B, wHTH domain [IPR019024]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "RmlD-like substrate binding domain [IPR029903]", "Rnh202, triple barrel domain [IPR041195]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNAP-25 domain [IPR000928]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN domain [IPR012919]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Siah interacting protein, N-terminal [IPR015120]", "Sialidase [IPR011040]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-8, SNARE domain [IPR041875]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM27, PRY/SPRY domain [IPR035791]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere repeat-binding factor, dimerisation domain [IPR013867]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Telomeric repeat-binding factor 2, Rap1-binding domain [IPR031902]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thg1 C-terminal domain [IPR025845]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim44-like domain [IPR007379]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UDP-glucuronate decarboxylase N-terminal [IPR021761]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps4 oligomerisation, C-terminal [IPR015415]", "W2 domain [IPR003307]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZMYND8/11, PWWP domain [IPR035505]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger C2HC RNF-type [IPR034734]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C2HC5-type [IPR009349]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNAHis guanylyltransferase catalytic domain [IPR024956]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AKAP1", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APMAP", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARMCX3", "ARMT1", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATAD5", "ATIC", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BCAP31", "BIRC6", "BLM", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BZW1", "BZW2", "C11orf58", "C1orf35", "CACUL1", "CACYBP", "CAD", "CALM3", "CALU", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CD2AP", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMBL", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNPY2", "COIL", "COLEC12", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNBL1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCTN1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERI1", "ERLIN2", "ERMP1", "ERP29", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM208A", "FAM208B", "FAM49B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXC1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCN1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "INCENP", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "IVD", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC47", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAK16", "MAN2B1", "MANF", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MEPCE", "METAP2", "METTL13", "MFN1", "MGA", "MIA3", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPHOSPH8", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA8", "NDUFA9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NEK9", "NELFA", "NENF", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP98", "NVL", "NXF1", "NXN", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B3", "PAICS", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PEF1", "PELP1", "PES1", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF3", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP4C", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PUF60", "PUM1", "PUM3", "PUS1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REPS1", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RNASEH2B", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRP12", "RSF1", "RTFDC1", "RTN3", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCP2", "SCRIB", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD1A", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SLC4A1AP", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STOML2", "STRBP", "STUB1", "STX12", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCERG1", "TCOF1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX10", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD3", "TIAL1", "TIMM44", "TIMM50", "TJP1", "TJP2", "TKT", "TLN1", "TMED10", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSR1", "TSTA3", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VCP", "VIM", "VIRMA", "VKORC1L1", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WDHD1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR43", "WDR46", "WIZ", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YBX3", "YKT6", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZYX"], "leading_proteins": ["AARS", "AARSD1", "ACOT7", "ACTN1", "ACTN2", "AIFM1", "AKAP8L", "AKR1A1", "AKR1B1", "ANLN", "AP1B1", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2S1", "AP3M1", "AP3S1", "APRT", "ARIH1", "ARL1", "BAIAP2", "BSG", "BUB1", "BZW2", "CACUL1", "CALM3", "CAPN1", "CAPN2", "CARHSP1", "CCNB1", "CHD1", "CIRBP", "CLINT1", "CNN2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS7A", "COPS8", "COPZ1", "COTL1", "CPNE1", "CPSF7", "CSE1L", "CTPS2", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5D2", "DCTN1", "DDI2", "DICER1", "DNA2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC8", "DNAJC9", "DPYSL2", "DSC3", "EARS2", "EEA1", "EEF1D", "EEF1E1", "EHD1", "EHD4", "EIF3B", "EIF3E", "EIF3L", "EIF3M", "EIF4B", "EIF4G1", "EIF4G2", "EIF5", "EPRS", "EPS15", "ESF1", "EWSR1", "EZR", "FKBP10", "FKBP4", "FUBP1", "FUS", "FXR2", "G3BP1", "G3BP2", "GAPVD1", "GARS", "GGA2", "GNPDA1", "GRB2", "GSTM2", "HDGF", "HDGFL2", "HECTD1", "HMGB1", "HMGB3", "HNRNPAB", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPK", "HNRNPR", "HNRNPUL2", "HTATSF1", "IDH2", "IFT27", "INTS14", "IPO4", "IPO5", "IPO7", "IQGAP2", "ITCH", "KHDRBS1", "KHSRP", "KPNB1", "LARP1", "LARP4B", "LARP7", "LASP1", "LEMD3", "LMNB2", "LNPEP", "MAPRE1", "MAPRE2", "MARC2", "MCM4", "MCM7", "METTL13", "MFN1", "MIA3", "MPP6", "MSH2", "MSN", "MTAP", "MYCBP2", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO6", "NAA40", "NARS", "NEFM", "NHLRC2", "NISCH", "NLE1", "NPEPPS", "NSF", "NSMCE3", "NUCB1", "NUCB2", "OLA1", "OSBPL9", "P4HA2", "PABPC4", "PALLD", "PDCD6", "PDLIM1", "PDLIM5", "PFAS", "PGM1", "PGM3", "PIN1", "PKN2", "PLEC", "PLOD3", "POLA1", "POLR2B", "PPIL3", "PQBP1", "PRKACA", "PRKAR1A", "PRMT3", "PRPS2", "PRPSAP2", "PSMA2", "PSMA4", "PSMC1", "PSMC3", "PSMC5", "PSMC6", "PSMD3", "PSMD6", "PSMD8", "PSME1", "PTBP2", "PTPN11", "PUM1", "RAD23B", "RANBP3", "RANBP9", "RBBP6", "RBM10", "RBM12", "RBM15", "RBM19", "RBM26", "RBM3", "RBMX", "RDX", "RHOA", "RNF20", "RNF40", "RPS6KA1", "RPS6KA3", "RRBP1", "RREB1", "S100A11", "S100A13", "SCAF11", "SCAF4", "SEC23IP", "SEPHS1", "SEPT11", "SEPT8", "SEPT9", "SETD1A", "SF1", "SLC9A3R1", "SMARCAD1", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMYD3", "SNX2", "SNX5", "SPART", "SRI", "SRSF12", "SRSF6", "SSRP1", "STAT3", "STX12", "STXBP4", "TAF15", "TAGLN2", "TARDBP", "TARS", "TARS2", "TBC1D15", "TBCE", "TCERG1", "TJP2", "TLN1", "TNPO1", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRMT2A", "TSR1", "TXNL1", "UBA3", "UBA6", "UBAP2L", "UBE2L3", "UBE2M", "UBE2S", "UBE3C", "UBQLN4", "UBR5", "UBXN1", "UHRF1", "USP33", "USP48", "USP5", "USP9X", "XPO5", "XPOT", "YARS", "YBX1", "YBX3", "YWHAB", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZFYVE16", "ZYX"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..cf1055ec529245b750ed79c477a9951fd7878bb0 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]"} \ No newline at end of file diff --git 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/dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]", "2": "14-3-3 protein [IPR000308]", "3": "26S proteasome regulatory subunit P45-like [IPR005937]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..0694e35fdb43fa7193d3cd2b7c735c0aba50d95f --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1ad8e13711e063d5a8d8d0c49fd5e5def1e890a221466eac87066dd477efe869 +size 140702 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..8b8dfe46b6faf04df4de6f831f6210b41abfb728 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:68709dc129f05b2c7d81c8360bfb6abfcf48fa21e19459081d793e2ee01a09ea +size 137625 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..6db41fc7d6b9683f97ace605e1773de456dd07bc --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6e6f36487b18e0628f047c8135372c24ff45d046c7f915de7091f0ca9ca6dac6 +size 132865 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..b9248096e87107ca0a8c1621a610075be324843b --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1ae8df43256b807b184764cbed3a308619c1e7a2701566da83683623f2604694 +size 144309 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..63389109f7ec0324654188fb317b07365bc65bb6 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8e486a18b11210eef5f55b7e8634c28a658f6c66bc03a235f52e74aed9921938 +size 330846 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fee04e5c4094c975e0735d8771d9bbcec56b5a65 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome, subunit alpha/beta [IPR001353] 7 14 2.5669443820410778 0.0102599067376196 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 1.0 1.0 5.108383317495765e-06 6.646444556359452e-07 1.8433914116255e-07 +Proteasome B-type subunit [IPR023333] 5 7 2.432740871592172 0.0149850208054629 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 1.0 3.681542547339912e-07 7.924739528757158e-09 7.11341310276029e-07 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b25e6475b86c7ef56f76fb4f93014d9d182e9909 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 1938, + "title": "Average number of proteins per term", + "value": 1.2657378740970073 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a38a9a81a8afd33f6ca0f98a7cbed1fa1bd389cd --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..41dbefef6855cae51ddc3826ac15a6e644739681 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,96 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome, subunit alpha/beta [IPR001353] 0.7438998192188836 2.5669443820410778 0.0102599067376196 0.9999999979106332 0.0658400637665792 14 Q99436,P49721,P28072,P28074,P28070,P25789,P20618 7 +Proteasome B-type subunit [IPR023333] 0.8713450676977229 2.4327408715921717 0.0149850208054629 0.999999999999804 0.0748478616520288 7 Q99436,P49721,P28072,P28074,P28070 5 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.9091041845590876 2.0120858824111933 0.0442108845953002 1.0 0.1333652584869138 4 P55786,Q9UIQ6 2 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.9975470155355683 1.9195633405162775 0.0549130783563431 1.0 0.1529045199060245 2 P48735 1 +Mpv17/PMP22 [IPR007248] 0.9766966475878986 1.8361858500039463 0.0663301746879987 1.0 0.1700368763827269 2 Q567V2 1 +Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237] 0.969746524938676 1.8083075671432831 0.0705586447955683 1.0 0.1759879711889466 2 Q7L2H7 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.9734151329243346 1.7502383530738608 0.0800771933763431 1.0 0.1906166614669791 3 P28072,P28074 2 +Aminopeptidase N-type [IPR034016] 0.9513491414554378 1.7343257747251806 0.0828602967187261 1.0 0.1939390443564653 2 Q9UIQ6 1 +Protein arginine N-methyltransferase [IPR025799] 0.8256955810147263 1.6879669771323116 0.0914175682186106 1.0 0.2069449029726962 4 O60678,Q99873,O14744 3 +TAF15/EWS/TLS family [IPR034870] 0.9501022494887524 1.6641394933250038 0.0960845563121437 1.0 0.2126856411357185 3 Q01844,P35637 2 +Nucleobindin [IPR040250] 0.926001635322977 1.6320157762005356 0.1026761627965751 1.0 0.2225798696865353 2 P80303 1 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666] 0.9227309893704018 1.6187880513711397 0.1054928738743685 1.0 0.2269088573739059 2 Q9H2H8 1 +Prefoldin alpha-like [IPR004127] 0.8851185609157806 1.4663907588623395 0.1425418624605607 1.0 0.2743696224075392 2 Q99471 1 +CTP synthase [IPR004468] 0.8834832379394956 1.4597579801031637 0.1443566007573626 1.0 0.2772676831196916 2 Q9NRF8 1 +Microtubule-associated protein RP/EB [IPR027328] 0.8806214227309916 1.448150301318927 0.1475750203293415 1.0 0.2812196552588633 2 Q15691 1 +ThiF/MoeB/HesA family [IPR045886] 0.6612601058036002 1.436099658132927 0.1509739853744607 1.0 0.2860093681873948 6 Q8TBC4,A0AVT1 2 +Peptidase C2, calpain family [IPR022684] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.3336315835776636 2 P07384 1 +Prefoldin beta-like [IPR002777] 0.8417825020441545 1.2907380666058983 0.1967945200349279 1.0 0.3408291151275159 2 O15212 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.8393295175797235 1.2808149801440254 0.2002586610600834 1.0 0.3439312436130254 2 Q9ULX6 1 +Tumour protein D52 [IPR007327] 0.8364677023712206 1.269242703821635 0.204354514599272 1.0 0.3480132243351398 2 O43399 1 +Actin-related protein 2/3 complex subunit 1 [IPR017383] 0.8360588716271471 1.2675899538503437 0.2049444213966469 1.0 0.3485865965581548 2 Q92747 1 +Importin beta family [IPR040122] 0.7139934533551463 1.243715866778975 0.2136041542511528 1.0 0.357482600119805 4 Q8TEX9,O00410,Q92973 3 +Small GTPase superfamily, ARF type [IPR024156] 0.816026165167624 1.1867675955992851 0.2353193038795529 1.0 0.3806751343226824 2 P40616 1 +Alpha-D-phosphohexomutase superfamily [IPR005841] 0.8029435813573219 1.134206361948465 0.2567079960159011 1.0 0.4048007292748709 2 P36871 1 +Small GTPase [IPR001806] 0.4232145088877573 1.1271817143267264 0.2596656600210625 1.0 0.4062993544385943 21 P20339,P61586,Q9BW83 3 +Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936] 0.7946464491990352 1.086001597640719 0.2774782854134137 1.0 0.4254374344392371 3 Q9H2H8 1 +La domain containing protein [IPR045180] 0.6120004674035243 1.0676299513325618 0.2856874675392959 1.0 0.4308656125223001 5 Q92615,Q6PKG0,Q4G0J3 3 +KH domain-containing BBP-like [IPR045071] 0.7881390593047073 1.0620123935822372 0.2882300588553337 1.0 0.4327459243902383 3 Q15637,Q07666 2 +DNA2/NAM7-like helicase [IPR045055] 0.6572055380990843 1.0176083798812214 0.3088641033679746 1.0 0.4520986648996487 4 P51530 1 +Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081] 0.7714636140637816 1.0087903693315052 0.3130751807720464 1.0 0.4561952634106962 2 Q92688 1 +Dynein family light intermediate chain [IPR022780] 0.7657399836467735 0.98619449431944 0.3240376804989155 1.0 0.4651740924495543 2 Q9Y6G9 1 +Dynein 1 light intermediate chain [IPR008467] 0.7657399836467735 0.98619449431944 0.3240376804989155 1.0 0.4651740924495543 2 Q9Y6G9 1 +Phosphatidylinositol transfer protein [IPR001666] 0.7628781684382697 0.974925101886534 0.3295974135863087 1.0 0.4707146555123553 2 Q00169 1 +DNA mismatch repair MutS family [IPR045076] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.4715075135389728 2 P43246 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.7553473915013826 0.9420826265828453 0.346150338552764 1.0 0.4848853636683126 3 Q01105 1 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.5816257108384669 0.9406806168180392 0.3468685550068333 1.0 0.4848853636683126 5 P40616 1 +CPSF6/7 family [IPR034772] 0.7502044153720394 0.9252681666301894 0.3548264331049418 1.0 0.4918838536175802 2 Q8N684 1 +DNA-directed RNA polymerase, subunit 2 [IPR015712] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.4988097120958618 2 P30876 1 +Clathrin adaptor, mu subunit [IPR001392] 0.7280524123739734 0.8439084222438878 0.3987205814519301 1.0 0.5283326728639013 3 Q9BXS5 1 +Proteasome alpha-type subunit [IPR023332] 0.5045153331071269 0.8237383082755078 0.4100882675955322 1.0 0.5373570402975939 7 P25787,P25789 2 +Ezrin/radixin/moesin [IPR011174] 0.7092024539877205 0.777300069075937 0.4369817543066383 1.0 0.5593597356976652 3 P15311,P35241 2 +26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585] 0.7048242027800538 0.7517378557281029 0.4522087202694558 1.0 0.5698182704045548 2 Q15008 1 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.6932337141505439 0.7218159905643556 0.4704076168572717 1.0 0.5858932914327716 3 Q5TFE4 1 +Melanoma-associated antigen [IPR037445] 0.696238757154543 0.7198565626414362 0.4716133148619692 1.0 0.5866409526331812 2 Q96MG7 1 +Coatomer gamma subunit [IPR017106] 0.6954210956663991 0.7168389450514846 0.4734734783088989 1.0 0.5874466075305033 2 Q9UBF2 1 +Ezrin/radixin/moesin-like [IPR000798] 0.5023473828453893 0.6213355243001575 0.5343788847683593 1.0 0.6349639967388597 5 P15311,P35241,P26038 3 +FAM98 [IPR018797] 0.668029435813579 0.6178479732211609 0.5366755568655959 1.0 0.6351507265316186 2 Q8NCA5 1 +Initiation factor 4G [IPR045208] 0.6586225777635724 0.6052556343085114 0.5450091550119738 1.0 0.6393630402016981 3 Q04637 1 +Adaptor protein complex, sigma subunit [IPR016635] 0.6635322976287877 0.6020232865607431 0.5471586368373664 1.0 0.6407211106893149 2 P53680 1 +Lupus La protein [IPR002344] 0.654129190515133 0.5693704278237927 0.5691047811542815 1.0 0.6525496935917829 2 Q4G0J3 1 +Glycogen/starch/alpha-glucan phosphorylase [IPR011833] 0.6529026982829174 0.5651564787813698 0.5719673357907868 1.0 0.6539661927802625 2 P06737 1 +Glycosyl transferase, family 35 [IPR000811] 0.6529026982829174 0.5651564787813698 0.5719673357907868 1.0 0.6539661927802625 2 P06737 1 +Taxilin family [IPR026183] 0.6512673753066294 0.5595545828081379 0.5757832908969711 1.0 0.6575533398693754 2 Q9NUQ3 1 +Ubiquitin-activating enzyme E1 [IPR018075] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.6626668757432628 2 A0AVT1 1 +THRAP3/BCLAF1 family [IPR029199] 0.6418642681929747 0.527725494868772 0.597689875356942 1.0 0.6692725888057712 2 Q9Y2W1 1 +Septin [IPR016491] 0.4771515070131565 0.5264732940312052 0.5985594026011962 1.0 0.6693641790196874 5 Q92599,Q9NVA2,Q9UHD8 3 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.6402289452166869 0.5222584621559108 0.6014903860859897 1.0 0.6707067711361612 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.6402289452166869 0.5222584621559108 0.6014903860859897 1.0 0.6707067711361612 2 Q93050 1 +Proteasome activator PA28 [IPR009077] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.6738779262567175 3 Q06323 1 +DnaJ homolog subfamily A member 1/2-like [IPR044713] 0.6365494685200395 0.5100344136941491 0.6100273523314712 1.0 0.6763346732370659 2 P31689 1 +Chaperone DnaJ [IPR012724] 0.6365494685200395 0.5100344136941491 0.6100273523314712 1.0 0.6763346732370659 2 P31689 1 +DNA-directed DNA polymerase, family B [IPR006172] 0.6245415860342958 0.4967572534054122 0.6193602427799729 1.0 0.6823502267094532 3 P09884 1 +Ras GTPase-activating protein-binding protein [IPR039539] 0.6234668847097375 0.4674689896736442 0.6401643735766971 1.0 0.69578489760014 2 Q9UN86 1 +Ribose-phosphate pyrophosphokinase [IPR005946] 0.614314928425366 0.465675900456363 0.6414475050726134 1.0 0.6960387821000699 3 P11908,O60256 2 +Ubiquitin/SUMO-activating enzyme E1 [IPR000011] 0.60695296523518 0.4437741352231174 0.6572058901612456 1.0 0.7031664955577821 3 A0AVT1,P22314 2 +Vinculin/alpha-catenin [IPR006077] 0.6144726083401546 0.4390653190804529 0.6606142075748442 1.0 0.7056105732473151 2 P18206 1 +Mini-chromosome maintenance protein [IPR031327] 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.7096167341970988 6 P33993,P33991 2 +Aldo-keto reductase [IPR020471] 0.5977105478332051 0.388155323514135 0.6979010928689742 1.0 0.7322860411370178 2 P15121 1 +Purine 5'-nucleotidase [IPR016695] 0.5973017170891329 0.386948200721842 0.6987945562598026 1.0 0.7328267586750526 2 Q9H857 1 +Filamin family [IPR044801] 0.574642126789371 0.3528320621205486 0.7242143455699297 1.0 0.7590737705324628 3 O75369,P21333 2 +Intracellular chloride channel [IPR002946] 0.5633687653311619 0.2930169588484958 0.7695091890519343 1.0 0.8035069010682375 2 Q9Y696 1 +HnRNP R/Q splicing factor [IPR006535] 0.5449713818479245 0.2476637054230012 0.8043946159763027 1.0 0.8349848772158943 2 O43390 1 +Ran binding protein RanBP1-like [IPR045255] 0.4336991565032408 0.245978617680536 0.8056987846791466 1.0 0.8358909232913202 4 Q9H6Z4 1 +Ribosome biogenesis protein Bms1/Tsr1 [IPR039761] 0.5367947669664859 0.2288548887329712 0.8189817036310161 1.0 0.8483092151987757 2 Q2NL82 1 +26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134] 0.5351594439901981 0.2251951841560075 0.8218274357276838 1.0 0.8508021209616726 2 O00232 1 +14-3-3 protein [IPR000308] 0.3493038493038494 0.2013293122383055 0.8404410839381111 1.0 0.8682168553689016 6 P61981,Q04917,P31946,P27348,P63104 5 +Peroxiredoxin, AhpC-type [IPR024706] 0.5233033524121117 0.199695121018261 0.841719029784536 1.0 0.8690737771563297 2 P30041 1 +26S proteasome regulatory subunit P45-like [IPR005937] 0.3218673218673202 0.1366350906390366 0.8913192382918949 1.0 0.915408947434919 6 P62195,P35998,P62333,P62191,P17980 5 +Aminoacyl-tRNA synthetase, class Ic [IPR002305] 0.455717705440659 0.1096999477255805 0.9126473418759152 1.0 0.9348364421540823 3 P23381 1 +Sister chromatid cohesion protein Pds5 [IPR039776] 0.4607522485691045 0.0957965159722981 0.9236821844862396 1.0 0.9446417274587504 2 Q29RF7 1 +Cell-cycle alteration and expression-elevated protein in tumour [IPR032337] 0.4437627811860993 0.0942079987895118 0.9249439309207012 1.0 0.9454331952132484 3 Q9NQG5,Q5VT52 2 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.4414214683030069 0.0913643467612163 0.9272030903901444 1.0 0.9472427987222456 3 P51116 1 +Cullin [IPR045093] 0.3119115841178891 0.0814795418800377 0.9350605939902472 1.0 0.9547668235790828 5 Q13617,Q13616,Q93034,Q13620 4 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.4206868356500519 0.0550650784793819 0.9560866172506092 1.0 0.9725637000567352 2 Q9UBM7 1 +Glutamyl/glutaminyl-tRNA synthetase [IPR000924] 0.4028629856850715 0.0530487131393637 0.9576930948544152 1.0 0.972922449896284 3 Q5JPH6,P07814 2 +Exportin-1/5 [IPR045065] 0.4178250204415483 0.0528370628372809 0.9578617308576418 1.0 0.972922449896284 2 Q9HAV4 1 +Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492] 0.4047424366312433 0.0436841508458826 0.965156172949012 1.0 0.977769295961937 2 P62424 1 +Formate-tetrahydrofolate ligase, FTHFS [IPR000559] 0.3912510220768675 0.0358916562908675 0.9713687488978712 1.0 0.98200972110802 2 P11586 1 +UDPGP family [IPR002618] 0.3753066230580604 0.0285855598937973 0.977195128914601 1.0 0.9863563332481754 2 Q16222 1 +Isoleucine-tRNA ligase [IPR002301] 0.3536385936222479 0.0214251155668356 0.9829065388369432 1.0 0.9905735165189788 2 P41252 1 +Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661] 0.3479149632052413 0.01998021022868 0.9840591593646424 1.0 0.9912196729982728 2 O43683 1 +Structural maintenance of chromosomes protein [IPR024704] 0.2729132569558107 0.0187997709011399 0.985000836585739 1.0 0.991652790287357 4 Q9NTJ3,Q9UQE7,O95347 3 +cAMP-dependent protein kinase regulatory subunit [IPR012198] 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 0.992885471084396 2 P10644 1 +Tyrosine-tRNA ligase [IPR002307] 0.307031888798046 0.0135838245064929 0.9891620094554952 1.0 0.9939860084955586 2 P54577 1 +GDP-fucose protein O-fucosyltransferase [IPR019378] 0.2955846279640315 0.0126802855222823 0.9898828670776204 1.0 0.9939860084955586 2 Q9Y2G5 1 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2f9e61df76507729b348cd880d9cfed1841942d9 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1-Cys peroxiredoxin [IPR045020]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-keto-steroid reductase [IPR042829]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABT1/Esf2 [IPR039119]", "ADF/Cofilin [IPR017904]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Aconitase, mitochondrial-like [IPR006248]", "Actin family [IPR004000]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Activating signal cointegrator 1-like [IPR039128]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Antifreeze, type III [IPR006013]", "Apolipoprotein CIII [IPR008403]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator BAX [IPR026304]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicaudal-D protein [IPR018477]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK2-associated and cullin domain-containing protein 1 [IPR042652]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carboxymethylenebutenolidase homolog [IPR042946]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Claspin [IPR024146]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoplasmic tRNA 2-thiolation protein 2 [IPR019407]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDB1- and CUL4-associated factor 8-like [IPR045151]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxyribonuclease II [IPR004947]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphosphomevalonate decarboxylase [IPR029765]", "Diphosphomevalonate/phosphomevalonate decarboxylase [IPR005935]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase HECTD3 [IPR042469]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand calcium-binding domain-containing protein 14 [IPR042352]", "EF-hand domain-containing protein D1/2 [IPR040365]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELMO domain-containing protein 2 [IPR030724]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endophilin-A [IPR028501]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM98 [IPR018797]", "FUN14 [IPR007014]", "Family of unknown function DUF5525 [IPR037656]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase 2-like [IPR045130]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-glutamyltranspeptidase [IPR000101]", "Gamma-tubulin complex component protein [IPR007259]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Glomulin/ALF4 [IPR019516]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanidinoacetate N-methyltransferase [IPR016550]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase EHMT2 [IPR038034]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 7 [IPR033060]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF20B [IPR028828]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase phosphoprotein 6 [IPR019324]", "MAX gene-associated protein [IPR037935]", "MCU family [IPR039055]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit Mic13 [IPR026769]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Major facilitator superfamily [IPR011701]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannose-P-dolichol utilization defect 1 protein [IPR016817]", "Mediator complex, subunit Med23 [IPR021629]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Neogenin [IPR033024]", "Neurofilament medium polypeptide [IPR027697]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nuclear RNA export factor [IPR030217]", "Nuclear RNA-splicing-associated protein, SR-25 [IPR019532]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC family [IPR037898]", "OCIA domain-containing protein 1/2 [IPR040187]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PH-interacting protein [IPR028738]", "PHD finger protein 10 [IPR038045]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor Isy1 [IPR009360]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FRG1 [IPR010414]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SMG8 [IPR028802]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kinase Mps1 family [IPR027084]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA methyltransferase [IPR003750]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate homeostasis protein [IPR011078]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab3GAP catalytic subunit [IPR045700]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma protein family [IPR028309]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2 subunit B [IPR040456]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAFB-like transcription modulator [IPR034780]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF60B [IPR030090]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 8 [IPR030646]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 12 [IPR034477]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialidase family [IPR026856]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP19 subunit [IPR002778]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smg8/Smg9 [IPR019354]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 25 member 44 [IPR042164]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of hairless-like [IPR040159]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Syntaxin [IPR045242]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "THO complex subunit 2 [IPR040007]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Telomeric repeat-binding factor 1/2 [IPR017357]", "Telomeric repeat-binding factor 2 [IPR030657]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription factor, T-box [IPR001699]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 161A/B [IPR019395]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-glucuronic acid decarboxylase [IPR044516]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised protein family UPF0449 [IPR028227]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 638 [IPR033096]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA-specific 2-thiouridylase [IPR004506]", "tRNAHis guanylyltransferase Thg1 [IPR007537]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR1A", "ACTR3", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANKLE2", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARL6IP5", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD3A", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "B4GAT1", "BABAM2", "BAIAP2", "BANF1", "BASP1", "BAX", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUD31", "BYSL", "C11orf58", "C15orf39", "C19orf25", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "C5orf15", "CAB39", "CACUL1", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDH2", "CDK5RAP3", "CDKAL1", "CDS2", "CEBPZ", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHERP", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CIAPIN1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COA7", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DCAF1", "DCAF8", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJC2", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPM1", "DPP3", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EFCAB14", "EFHD1", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERCC2", "ERGIC1", "ERGIC3", "ERH", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAM114A2", "FAM120A", "FAM162A", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GCAT", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GEMIN4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GNA13", "GNAI3", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GPS1", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HCFC1", "HDAC1", "HDAC2", "HDHD5", "HEATR1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO4", "IPO5", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LNPEP", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSG1", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "M6PR", "MACF1", "MAGED2", "MAK16", "MANF", "MAP1S", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED23", "MEPCE", "METAP2", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MTX1", "MTX2", "MVD", "MYBBP1A", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA35", "NAA40", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA4", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEFM", "NELFB", "NEO1", "NEU1", "NFS1", "NHP2", "NIP7", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSF", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAK2", "PANK4", "PAPSS1", "PARK7", "PBRM1", "PC", "PCBD1", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PEBP1", "PECR", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIR", "PITHD1", "PITPNA", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLEC", "PLIN3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIE", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PTBP1", "PTBP2", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM5", "RBM8A", "RBPJ", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RFC1", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RNASEH2B", "RNASET2", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCPEP1", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC9A3R1", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG8", "SMPD4", "SMU1", 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0000000000000000000000000000000000000000..0712a1a9e79d92449353a9a92b48e6a394b9c210 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:62d9ae9b02d3f72f6d677083bf8d24fd3a43e282ba9058f78bd84678d01e0887 +size 133056 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..07f1ee66abc813363fe9b973ea668cdbd5140eea --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tetratricopeptide-like helical domain superfamily [IPR011990] 26 72 2.581042040887905 0.0098502585437139 22.856796116504853 85.5631067961165 0.5676132842696584 0.6143258973719493 7.683128498309678 5.891280215778877 0.9202004538980384 0.371378017802006 1.0 0.0137124493656786 0.0409125995904301 0.0128845879482844 4.394643380006354e-05 +Nucleophile aminohydrolases, N-terminal [IPR029055] 8 19 2.3797992546537734 0.0173220717163478 6.097087378640777 17.820388349514563 1.118176330768516 0.343571999079937 2.960138290874742 0.7151426259133536 1.128434210928413 0.3328142150103464 1.0 1.0 3.372095645888767e-05 1.2471773076216153e-05 9.520463524587626e-07 +SH3-like domain superfamily [IPR036028] 6 15 2.376680509740918 0.0174692116397654 7.827669902912621 30.75485436893204 0.1458604778244563 0.6315015103936021 4.313774664050148 5.335410260579265 0.8529860578790123 0.3168420523015797 1.0 0.3418769323526702 0.2883050513485111 0.3686905324840194 0.4802630672329203 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 1 5 2.001831515761753 0.0453028551724252 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 1.0 0.0347606010038453 0.0869978059975285 0.026979757634231 0.1038862441468568 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9e59edbfefa132390ba7ac9b663ecda4bbbe381c --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 876, + "title": "Average number of proteins per term", + "value": 4.313926940639269 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d1a78af8257c17ed93a11dc0038f9bf88af58fa5 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6abe2c20365b763619452002c2a9e04e46557ca1 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,140 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.4482111198526111 2.581042040887905 0.0098502585437139 0.9998286163121513 0.10033519167783 72 O75153,O76094,Q9UJX4,Q9H7B4,O15460,P31948,P30260,Q96EK5,Q9UBV2,Q9Y262,Q13325,P61201,O75718,Q6PD62,Q96TC7,O00231,Q02790,P49321,Q9H3U1,Q9H6T3,Q6DKK2,Q13451,O43242,Q9UJX2,Q15008,Q9BXJ9 26 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.6354117889376193 2.3797992546537734 0.0173220717163478 0.9999997749844286 0.1205240886142968 19 Q99436,Q9UJ14,P49721,P28072,P28074,P28070,P25789,P20618 8 +SH3-like domain superfamily [IPR036028] 0.6941914511848589 2.376680509740918 0.0174692116397654 0.9999998026471716 0.1205240886142968 15 Q9UQB8,P62993,Q14847,Q9UDY2,Q9NZW5,Q5JRA6 6 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.9091041845590876 2.0120858824111933 0.0442108845953002 1.0 0.2127952467334229 4 P55786,Q9UIQ6 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.9091041845590876 2.0120858824111933 0.0442108845953002 1.0 0.2127952467334229 4 P55786,Q9UIQ6 2 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8366507148229541 2.001831515761753 0.0453028551724252 1.0 0.2160016105299071 5 Q8WUJ1 1 +UBA-like superfamily [IPR009060] 0.6114110502326054 1.8719211363980184 0.0612175149351843 1.0 0.2666633023972527 14 Q9UNZ2,Q04323,Q9NRR5,Q14157,P43897 5 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.5066918550159912 1.784388121312986 0.0743606199302959 1.0 0.2961569515232443 24 Q8IZ69,O14744,O60678,Q08J23,Q99873,Q7L2J0,Q14353,Q9BV44,Q8N6R0,Q6FI81 10 +Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151] 0.957890433360589 1.7606598695195967 0.0782959888529253 1.0 0.3065089276968494 2 Q9C0B1 1 +Prefoldin [IPR009053] 0.8424713584288027 1.7538337912704671 0.0794589910972649 1.0 0.3066346969216039 4 P61758,O15212,Q99471 3 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5569019807765634 1.6767569135542597 0.0935900262983131 1.0 0.3404130217788384 16 O95831,Q8NB78,Q9UHG3 3 +AH/BAR domain superfamily [IPR027267] 0.6601045391267207 1.6521420406361191 0.0985055984649672 1.0 0.3437884631685708 8 Q13596,Q9Y5X3,Q9UQB8,O60749 4 +PDZ superfamily [IPR036034] 0.6038906217984176 1.6027098677739675 0.1089987239149994 1.0 0.3715287243172743 10 Q9UDY2,Q96HC4,Q9NZW5,O14745,O00151 5 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.6450868101358734 1.58242297014039 0.1135530443669972 1.0 0.3797335190305949 8 Q01844,P35637 2 +ADF-H/Gelsolin-like domain superfamily [IPR029006] 0.5952310987680047 1.559186117379764 0.1189523356558677 1.0 0.3843524588396177 10 Q15436,Q14019 2 +PIN-like domain superfamily [IPR029060] 0.7822453125017739 1.516074764612812 0.1295004484986024 1.0 0.4037095832198424 4 Q9UQ84 1 +EB1, C-terminal domain superfamily [IPR036133] 0.8806214227309916 1.448150301318927 0.1475750203293415 1.0 0.4294874345797448 2 Q15691 1 +Ubiquitin-activating enzyme [IPR035985] 0.6612601058036002 1.436099658132927 0.1509739853744607 1.0 0.4360791998940623 6 Q8TBC4,A0AVT1 2 +SH2 domain superfamily [IPR036860] 0.6335651956195654 1.4043739164037528 0.1602075338565283 1.0 0.4455794666158211 7 P40763,Q06124 2 +Ubiquitin-conjugating enzyme/RWD-like [IPR016135] 0.5716540912161144 1.3602995030162324 0.1737351655916499 1.0 0.4640000154216016 9 Q16763,P61081,Q9Y3C8 3 +Calpain large subunit, domain III superfamily [IPR036213] 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.4836001103926495 2 P07384 1 +Ubiquitin activating enzyme, alpha domain superfamily [IPR023318] 0.8421913327882281 1.2923922528669556 0.1962213382461262 1.0 0.4862785887412347 2 Q8TBC4 1 +Zinc finger, RING/FYVE/PHD-type [IPR013083] 0.375432404722653 1.2710914862463434 0.2036961037926814 1.0 0.4892819221388068 43 Q8TEY7,Q7Z3T8,Q9Y2K7,Q7Z6E9,Q9UPN9,Q92785,P45974,Q9Y4X5,Q96T88,Q99590,Q12899,P19474,O75592,Q13263,Q5VTR2,Q14258,Q15075,Q14139 18 +MFS transporter superfamily [IPR036259] 0.657910255206527 1.261074263720663 0.2072820920815039 1.0 0.4892819221388068 5 O00400,Q6N075 2 +Papain-like cysteine peptidase superfamily [IPR038765] 0.4860161897054013 1.2597009720410437 0.2077772546068905 1.0 0.4892819221388068 16 Q8TEY7,Q13867,Q96FW1,P45974,Q86UV5,P07384,Q9Y5K5,P17655,Q93008,Q9H4L4 10 +WW domain superfamily [IPR036020] 0.5897459840536423 1.206178670411561 0.2277486063056888 1.0 0.5120172436712453 7 Q13526,Q6ZWJ1,O60828,Q96J02 4 +HAD superfamily [IPR023214] 0.4957490630767371 1.1904960452968272 0.2338514834481686 1.0 0.5186174670901158 13 P34913 1 +HAD-like superfamily [IPR036412] 0.4957490630767371 1.1904960452968272 0.2338514834481686 1.0 0.5186174670901158 13 P34913 1 +Rab-GTPase-TBC domain superfamily [IPR035969] 0.6913180644769201 1.1531666095698945 0.2488420058093616 1.0 0.528607828150575 4 Q8TC07 1 +Translation elongation factor eEF-1beta-like superfamily [IPR036219] 0.8074407195421114 1.1522506877109142 0.2492180742308076 1.0 0.528607828150575 2 P29692 1 +Translation elongation factor EF1B/ribosomal protein S6 [IPR014717] 0.8074407195421114 1.1522506877109142 0.2492180742308076 1.0 0.528607828150575 2 P29692 1 +Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900] 0.803271983640085 1.1178739801179296 0.2636208193748128 1.0 0.5420935158975024 3 O95394,P36871 2 +Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055] 0.803271983640085 1.1178739801179296 0.2636208193748128 1.0 0.5420935158975024 3 O95394,P36871 2 +DUSP-like superfamily [IPR035927] 0.7978410027205249 1.0977964722639746 0.2722933722516059 1.0 0.5572406880357406 3 Q8TEY7 1 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.6734203290978413 1.081900599909238 0.2792966982829592 1.0 0.5631462134531878 4 Q9BXS5 1 +EF-hand domain pair [IPR011992] 0.3479808334021014 1.0144491817425252 0.3103684665306057 1.0 0.5800054815912175 43 O75340,P42566,Q9H4M9,Q9H8M7,P30626,P31949,P80303,P07384,Q9H223,P0DP25,Q02818,P17655,Q96AY3,P35609,Q99584 15 +Armadillo-type fold [IPR016024] 0.2832242440053256 1.0099642672274278 0.3125124100012233 1.0 0.5810629878072355 117 Q8TEX9,Q9BZZ5,Q7Z4Q2,Q92973,Q86Y56,Q7L2H7,P78344,Q99570,Q13200,O95373,Q04637,Q9ULT8,O60763,Q92600,Q9Y376,Q86VP6,Q15021,Q99460,Q96QK1,P55060,P55010,Q14974,Q9BTY7,Q9BTW9,P09960,Q10567,Q9UBB4,Q9H3U1,Q7L1Q6,Q7Z460,Q5T4S7,O43747,Q69YN4,Q5H9R7,Q7Z6Z7,Q9UBF2,Q8N3U4,Q9UI12,Q9Y6E2,Q6NXE6,Q5VYK3,O43592,O00410,P30153,O60684 45 +Arp2/3 complex subunit 2/4 [IPR034666] 0.7686017988552767 0.9974831516561008 0.3185300478655968 1.0 0.5849734212374482 2 O15144 1 +Immunoglobulin-like domain superfamily [IPR036179] 0.4962687365976966 0.9895641308631652 0.3223872094095741 1.0 0.5859153432422964 9 Q8WX93,P35613 2 +von Willebrand factor A-like domain superfamily [IPR036465] 0.4632380110401871 0.9824536975250118 0.32587638325974 1.0 0.5898093217676286 12 O95486,Q99829,P12956,Q96SY0,P10155,Q15436 6 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.591874816833147 2 P43246 1 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.591874816833147 2 P43246 1 +MutS, connector domain superfamily [IPR036678] 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.591874816833147 2 P43246 1 +NAP-like superfamily [IPR037231] 0.7553473915013826 0.9420826265828453 0.346150338552764 1.0 0.6144703581436428 3 Q01105 1 +B30.2/SPRY domain superfamily [IPR043136] 0.4716915676333112 0.93223351978692 0.351215856024655 1.0 0.620136696520955 10 P19474,Q14258,Q1KMD3,Q96S59 4 +MIT domain superfamily [IPR036181] 0.7521330089658471 0.9304312667401476 0.3521478361314871 1.0 0.620136696520955 3 Q8N0X7 1 +RNA polymerase Rpb2, OB-fold [IPR014724] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.626130870640335 2 P30876 1 +RNA polymerase Rpb2, domain 2 superfamily [IPR037034] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.626130870640335 2 P30876 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033] 0.7461161079313201 0.909344184115798 0.3631684745961099 1.0 0.626130870640335 2 P30876 1 +Ubiquitin-like domain superfamily [IPR029071] 0.3678869063903497 0.907410050311248 0.364189996631449 1.0 0.626130870640335 30 P15311,Q9UNZ2,P35241,Q15813,Q86UV5,Q96T88,Q04323,Q9NRR5,P54727,Q9Y490 10 +Zinc-binding ribosomal protein [IPR011332] 0.7447852760736219 0.9038817156741876 0.3660581254662678 1.0 0.6271133937254458 3 P83881,P61927 2 +Ribosomal protein L37ae/L37e [IPR011331] 0.7444807849550339 0.9029884419490068 0.366532029209393 1.0 0.6271133937254458 2 P61927 1 +HECT, E3 ligase catalytic domain [IPR035983] 0.5182345476846468 0.8843648388177529 0.3764992972712981 1.0 0.6391732256001108 7 Q9ULT8,Q15386,Q96J02 3 +Concanavalin A-like lectin/glucanase domain superfamily [IPR013320] 0.3963944790056437 0.8729743111597928 0.3826770798861869 1.0 0.6402385938023488 19 Q96S59,P49257,Q1KMD3,Q12899,P19474,O14786,P17931,Q14258 8 +Acyl-CoA N-acyltransferase [IPR016181] 0.4721520823074081 0.8724301276212045 0.3829737707219529 1.0 0.6402385938023488 9 Q86UY6 1 +Phosphoribosyltransferase-like [IPR029057] 0.5140267366889877 0.8657089231335385 0.3866498054234601 1.0 0.6405473130017644 7 O60256,P07741 2 +START-like domain superfamily [IPR023393] 0.6157861456765318 0.8553725978931785 0.3923449085518908 1.0 0.6412204102452544 4 Q9NQZ5,Q00169 2 +Mitochondrial carrier domain superfamily [IPR023395] 0.4065896659057166 0.8360938878486195 0.4031020866233095 1.0 0.6539211627444798 17 Q70HW3,O43772 2 +Moesin tail domain superfamily [IPR008954] 0.7092024539877205 0.777300069075937 0.4369817543066383 1.0 0.6906751511227012 3 P15311,P35241 2 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.2687283927258866 0.7754155295921106 0.4380941615531548 1.0 0.6906751511227012 119 Q96T37,P98175,Q8WXF0,P98179,Q14011,O43719,Q8IZ69,O14979,P23588,O15047,Q9Y2U8,Q13247,P55884,Q5T8P6,P35637,Q13148,Q9NTZ6,Q8N684,Q01844,Q13310,O95104,Q92804 22 +CAP Gly-rich domain superfamily [IPR036859] 0.6984744451989751 0.7399202992441405 0.4593483564661507 1.0 0.7032019329806809 3 Q14203 1 +Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449] 0.6932755076067685 0.7219599419114954 0.4703191062054408 1.0 0.7050055696571417 3 A0AVT1 1 +MAGE homology domain, winged helix WH2 motif [IPR041899] 0.696238757154543 0.7198565626414362 0.4716133148619692 1.0 0.7050055696571417 2 Q96MG7 1 +MAGE homology domain, winged helix WH1 motif [IPR041898] 0.696238757154543 0.7198565626414362 0.4716133148619692 1.0 0.7050055696571417 2 Q96MG7 1 +Coatomer, gamma subunit, appendage domain superfamily [IPR037067] 0.6954210956663991 0.7168389450514846 0.4734734783088989 1.0 0.7065805229959038 2 Q9UBF2 1 +Cyclin-like superfamily [IPR036915] 0.6913327882256799 0.7018016710817814 0.4828028564997415 1.0 0.7150919881123905 2 P14635 1 +Chaperone J-domain superfamily [IPR036869] 0.4088628213019274 0.697507599113071 0.4854851854020339 1.0 0.7150919881123905 12 O75937,P31689,Q9NVH1,Q96KC8,P25685,Q8WXX5 6 +Nucleoside phosphorylase superfamily [IPR035994] 0.6901062959934651 0.6973073102684049 0.4856104941424719 1.0 0.7150919881123905 2 Q13126 1 +PITH domain superfamily [IPR037047] 0.6815208503679532 0.6660733060570548 0.505364245788231 1.0 0.7317340153892403 2 O43396 1 +SNF2-like, N-terminal domain superfamily [IPR038718] 0.4024974400700597 0.5953648112401837 0.5515996418613907 1.0 0.7682055425605377 10 Q9H4L7 1 +RNA-binding domain superfamily [IPR035979] 0.2573253271862751 0.5872379306574642 0.5570439210093392 1.0 0.7687426317471001 122 Q96T37,P98175,Q8WXF0,P98179,Q14011,O43719,Q8IZ69,O14979,P23588,O15047,Q9Y2U8,Q13247,P55884,Q5T8P6,P35637,Q13148,Q9NTZ6,Q8N684,Q01844,Q13310,O95104,Q92804 22 +PurM-like, C-terminal domain superfamily [IPR036676] 0.6474437627811868 0.5688974935170711 0.5694257064591322 1.0 0.77335956412124 3 O15067,P49903 2 +PurM-like, N-terminal domain superfamily [IPR036921] 0.6474437627811868 0.5688974935170711 0.5694257064591322 1.0 0.77335956412124 3 O15067,P49903 2 +PX domain superfamily [IPR036871] 0.4253054157998572 0.5671493975523416 0.570612684266715 1.0 0.7737719990985176 8 Q9Y2I1,O60749,Q9Y5X3 3 +Isoprenoid synthase domain superfamily [IPR008949] 0.6484055600981258 0.549797852984542 0.5824580314371792 1.0 0.7781577002962488 2 P14324 1 +Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.7781577002962488 2 A0AVT1 1 +Ubiquitin-activating enzyme E1, SCCH domain [IPR042063] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.7781577002962488 2 A0AVT1 1 +Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302] 0.6475878986099819 0.5470212494624124 0.5843641334598741 1.0 0.7781577002962488 2 A0AVT1 1 +HSP40/DnaJ peptide-binding [IPR008971] 0.6368098159509155 0.5349878378474493 0.5926582673419323 1.0 0.7781577002962488 3 P31689,P25685 2 +Proteasome activator superfamily [IPR036252] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.7781577002962488 3 Q06323 1 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.7781577002962488 3 Q06323 1 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.6306560369984908 0.5156872346513398 0.6060728717572026 1.0 0.7781577002962488 3 Q06323 1 +Winged helix DNA-binding domain superfamily [IPR036390] 0.2980434695358144 0.5151010593648927 0.6064824024866793 1.0 0.7781577002962488 39 Q9UNS2,P60228,Q6PKG0,Q7L2H7,O43242,Q4G0J3,Q13098,Q15008,P61201,Q9UNM6,Q93034,O00231,P15927,P39019 14 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.6365494685200395 0.5100344136941491 0.6100273523314712 1.0 0.7781577002962488 2 P31689 1 +K Homology domain, type 1 superfamily [IPR036612] 0.322085945989492 0.4980375650751056 0.6184575653006923 1.0 0.7830363943911602 24 P51116,P61978,Q92945,Q15637,Q96AE4,Q07666 6 +DNA polymerase family B, thumb domain [IPR042087] 0.6245415860342958 0.4967572534054122 0.6193602427799729 1.0 0.7830363943911602 3 P09884 1 +DNA polymerase, palm domain superfamily [IPR023211] 0.6245415860342958 0.4967572534054122 0.6193602427799729 1.0 0.7830363943911602 3 P09884 1 +Longin-like domain superfamily [IPR011012] 0.3615938676890571 0.4675585501576975 0.6401003124148372 1.0 0.7927785083883528 12 Q9BXS5,P53680,Q9Y296,Q9Y2T2 4 +HIT-like superfamily [IPR036265] 0.6149324637063509 0.4675314334962029 0.6401197082399377 1.0 0.7927785083883528 3 Q69YN2 1 +Alpha-catenin/vinculin-like superfamily [IPR036723] 0.6147239263803657 0.4669045202066765 0.6405681911393901 1.0 0.7927785083883528 3 P18206,Q9Y490 2 +Metal-dependent hydrolase [IPR032466] 0.6222403924775216 0.463553239800315 0.642967862533721 1.0 0.7927785083883528 2 Q16555 1 +Metal-dependent hydrolase, composite domain superfamily [IPR011059] 0.6222403924775216 0.463553239800315 0.642967862533721 1.0 0.7927785083883528 2 Q16555 1 +NagB/RpiA transferase-like [IPR037171] 0.4293376294164102 0.4560157599319763 0.6483786453401279 1.0 0.7932677280976984 6 Q9UI10,O95336,P46926 3 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.6169255928045863 0.4467393726376766 0.6550632502615288 1.0 0.7957644821905394 2 Q9BYT8 1 +DNA/RNA polymerase superfamily [IPR043502] 0.500061634572227 0.4377224400864651 0.6615875004907896 1.0 0.7960808219509017 4 P09884 1 +Leucine-rich repeat domain superfamily [IPR032675] 0.3229959837835356 0.4017453995166488 0.6878714090396838 1.0 0.8023639871088721 18 Q9NYL9,Q9Y2K7,Q9Y2I1,Q15813,Q92688,Q9BTT0,Q9UQ13 7 +Cyclophilin-like domain superfamily [IPR029000] 0.3458117426517621 0.3870513024129179 0.6987182282450828 1.0 0.8106982356856854 11 Q9H2H8 1 +CH domain superfamily [IPR036872] 0.3071358523111759 0.3843548142778243 0.700715486166489 1.0 0.8119401665103761 21 P37802,Q15555,Q99439,P12814,Q15691,Q15149,P35609 7 +SPOC-like, C-terminal domain superfamily [IPR016194] 0.4825882136683336 0.3826939169439983 0.7019467253132792 1.0 0.8122923796227642 4 Q96T37 1 +FF domain superfamily [IPR036517] 0.5821749795584713 0.3435098405482151 0.7312149390341249 1.0 0.8428214297288072 2 O14776 1 +Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091] 0.4217431342030484 0.3370926224660164 0.7360470787232043 1.0 0.8461643582172269 5 O75592 1 +C2 domain superfamily [IPR035892] 0.3320988650998849 0.3309735682243574 0.740664450925201 1.0 0.8503565648892215 11 Q96J02 1 +NADP-dependent oxidoreductase domain superfamily [IPR036812] 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.8567985905469312 3 P14550,P15121 2 +PABC (PABP) domain [IPR036053] 0.5599182004090009 0.3144790997251899 0.7531571878677559 1.0 0.8592665136457011 3 Q13310,O95071 2 +FERM superfamily, second domain [IPR035963] 0.3560440641853062 0.250535215466677 0.8021734748303202 1.0 0.9031070172631028 7 P15311,P35241,P26038,Q9Y490 4 +SNARE [IPR010989] 0.5457890433360684 0.2495909671132687 0.8029036847510862 1.0 0.9031070172631028 2 Q86Y82 1 +Pyruvate kinase-like, insert domain superfamily [IPR011037] 0.5307868285210835 0.2449928338295651 0.8064619800853716 1.0 0.9045591479574718 3 Q969Z3 1 +Homeobox-like domain superfamily [IPR009057] 0.2866742745601496 0.2146659447859785 0.8300277757029308 1.0 0.928613450211708 17 Q8NB78 1 +FERM/acyl-CoA-binding protein superfamily [IPR014352] 0.3269458892344432 0.2093452572102629 0.8341787242427277 1.0 0.9320670439242724 8 P35241,Q9Y490 2 +14-3-3 domain superfamily [IPR036815] 0.3493038493038494 0.2013293122383055 0.8404410839381111 1.0 0.9354846118548734 6 P61981,Q04917,P31946,P27348,P63104 5 +Myosin S1 fragment, N-terminal [IPR008989] 0.4984054773592389 0.1786112668974278 0.8582429470529533 1.0 0.9528781009105032 3 P35579 1 +TGS-like [IPR012676] 0.3384777650816603 0.1742371754139535 0.861679070597487 1.0 0.95548210866253 6 P26639,Q9NTK5 2 +Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041] 0.3085729201003362 0.1600420432076617 0.8728479553499044 1.0 0.9612111510701202 8 O43747,Q9UBF2,Q10567 3 +Anticodon-binding domain superfamily [IPR036621] 0.355300859598855 0.1600100648760303 0.8728731457510555 1.0 0.9612111510701202 5 P26639,P07814,P41250,Q9HCD5 4 +PUA-like superfamily [IPR015947] 0.3310086702294173 0.1567260399196068 0.8754607637996796 1.0 0.9612111510701202 6 Q96T88,O43252 2 +PH-like domain superfamily [IPR011993] 0.2509812308517038 0.1406112938534756 0.8881770256829424 1.0 0.9706195971467548 34 Q96SU4,Q9NVZ3,P15311,P43487,O60343,P35241,Q86X55,Q9NQW6,Q9H6Z4,Q08945,Q9Y490 11 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.2706791199356366 0.1400422387807913 0.8886266174791067 1.0 0.9706195971467548 15 P24534,P28161,O43324 3 +Six-hairpin glycosidase superfamily [IPR008928] 0.4860997547015649 0.1316996327683312 0.8952218759966266 1.0 0.9753909992202052 2 Q13724 1 +Rho GTPase activation protein [IPR008936] 0.3723404255319136 0.1180305565729472 0.9060434464575552 1.0 0.9832994153166004 4 Q13576,P46940,Q14C86 3 +Armadillo-like helical [IPR011989] 0.228329886592483 0.1176814805806059 0.9063200411591004 1.0 0.9832994153166004 86 Q8TEX9,Q9BZZ5,Q7Z4Q2,Q92973,Q86Y56,Q99570,Q13200,O95373,Q9ULT8,O60763,Q92600,Q9Y376,Q86VP6,Q15021,Q99460,P55060,Q14974,Q9BTY7,Q9BTW9,Q10567,Q9UBB4,Q9H3U1,Q7Z460,O43747,Q9UBF2,Q9UI12,Q6NXE6,Q5VYK3,O43592,O00410,P30153,O60684 32 +Cullin repeat-like-containing domain superfamily [IPR016159] 0.3120393120393073 0.1167040382893022 0.9070945900547454 1.0 0.9832994153166004 6 Q13620,Q86Y37,Q13616,Q13617,Q93034 5 +Zinc finger C2H2 superfamily [IPR036236] 0.2612498216757433 0.1127581930001525 0.9102222640398288 1.0 0.9832994153166004 15 Q15428,O60678 2 +Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149] 0.4421267893660631 0.0922145015498897 0.9265276165665272 1.0 0.992222728743616 3 Q9NQW7,Q9Y5B9 2 +Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047] 0.2964782964782931 0.0887055078244871 0.9293159551836768 1.0 0.9938459095099316 6 Q8TEQ6,Q15269,Q8N766,Q9HC35,Q9HCU5 5 +Thioredoxin-like superfamily [IPR036249] 0.2366166190793586 0.0825246342379763 0.934229529853378 1.0 0.9938459095099316 37 P28161,Q9H2J4,Q8NBF2 3 +Cullin homology domain superfamily [IPR036317] 0.3119115841178891 0.0814795418800377 0.9350605939902472 1.0 0.9938459095099316 5 Q13617,Q13616,Q93034,Q13620 4 +RuvA domain 2-like [IPR010994] 0.4476696647588025 0.0804380589275756 0.935888858310736 1.0 0.9938459095099316 2 Q7KZ85 1 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.2453408488700796 0.0712446391878605 0.9432030547207032 1.0 0.9966777755552908 14 O60568 1 +Pseudouridine synthase, catalytic domain superfamily [IPR020103] 0.4337694194603526 0.0663512846731511 0.9470981538824156 1.0 0.9987660280233756 2 Q9Y606 1 +CDC48 domain 2-like superfamily [IPR029067] 0.4317252657399945 0.0644653481746378 0.9485996978486856 1.0 0.9987660280233756 2 P46459 1 +Protein-tyrosine phosphatase-like [IPR029021] 0.3198113594531728 0.0505231933075414 0.9597054674169854 1.0 0.999645647392722 4 Q06124 1 +Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035] 0.4026982829108824 0.0424003900396387 0.9661795174237456 1.0 1.0 2 P07814 1 +Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056] 0.4026982829108824 0.0424003900396387 0.9661795174237456 1.0 1.0 2 P07814 1 +SMCs flexible hinge superfamily [IPR036277] 0.2730249693000421 0.0364249348311476 0.9709435322487576 1.0 1.0 5 Q9NTJ3,A6NHR9,Q9UQE7,O95347 4 +Chromo-like domain superfamily [IPR016197] 0.2470294080056059 0.0323880374337778 0.9741626022294848 1.0 1.0 7 O14646 1 +Beta-grasp domain superfamily [IPR012675] 0.2449610109480708 0.030339689372543 0.9757961435889124 1.0 1.0 7 P26639,Q9NTK5 2 +High mobility group box domain superfamily [IPR036910] 0.2164281232815989 0.0242962971231324 0.9806162667283054 1.0 1.0 9 P09429,Q08945,O15347 3 +Cyclic nucleotide-binding-like [IPR018490] 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 +LEM/LEM-like domain superfamily [IPR011015] 0.2283851011503143 0.009089447594104 0.9927477699594348 1.0 1.0 5 Q9Y2U8 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cdb5ae5b0172a080e7b11453efe6fd33123b2ea7 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "Apolipoprotein CIII superfamily [IPR038195]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Beta-trefoil domain superfamily [IPR036358]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CH domain superfamily [IPR036872]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavin prenyltransferase-like [IPR036551]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-glutamyltranspeptidase, large subunit, C-terminal domain [IPR043138]", "Gamma-glutamyltranspeptidase, small subunit [IPR043137]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Helix hairpin bin domain superfamily [IPR029012]", "Helix-loop-helix DNA-binding domain superfamily [IPR036638]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PLP-binding barrel [IPR029066]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Pre-mRNA-splicing factor Isy1 superfamily [IPR037200]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RBP-J/Cbf11, DNA binding domain superfamily [IPR037095]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Sialidase superfamily [IPR036278]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Signal recognition particle, subunit SRP19-like superfamily [IPR036521]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "T-box superfamily [IPR036960]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Telomere repeat-binding factor, dimerisation domain superfamily [IPR036507]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tma16 superfamily [IPR038356]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ufd1-like, Nn domain [IPR042299]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "tRNAHis guanylyltransferase Thg1 superfamily [IPR038469]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOC3", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATXN10", "AURKA", "BAG6", "BAIAP2", "BANF1", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCL2L13", "BDH2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "CAB39", "CACUL1", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDKAL1", "CEBPZ", "CELF1", "CERS2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CIAPIN1", "CIRBP", "CISD2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "COA7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCAKD", "DCPS", "DCTN1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DHCR24", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERH", "ERI1", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FKBP10", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMPDH2", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LACTB", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAN2B1", "MANF", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MEPCE", "METAP2", "METTL13", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPHOSPH8", "MPI", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL9", "MRPS15", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NENF", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B3", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF3", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PUS1", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RREB1", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSF1", "RSL1D1", "RTCB", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC3A2", "SLC4A1AP", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STUB1", "STX12", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCERG1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFRC", "THG1L", "THOC1", "THOC3", "THOP1", "THUMPD3", "TIAL1", "TIGAR", "TIMM44", "TIMM50", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMA16", "TMED7", "TMEM14C", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TPD52L2", "TPI1", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSTA3", "TTC1", "TTC19", "TTC37", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZCCHC3", "ZFR", "ZFYVE16", "ZMYND8", "ZNF281", "ZNF512B", "ZNF638", "ZNF687", "ZPR1"], "leading_proteins": ["ACTN1", "ACTN2", "AIFM1", "AKR1A1", "AKR1B1", "ANAPC5", "ANLN", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2S1", "AP3M1", "API5", "APRT", "ARIH1", "ARMC6", "ARPC2", "ATP6V1H", "ATXN10", "BAIAP2", "BLMH", "BSG", "BZW1", "BZW2", "CAB39", "CACUL1", "CALM3", "CAND1", "CAPN1", "CAPN2", "CARM1", "CCNB1", "CDC23", "CDC27", "CHD1", "CIAPIN1", "CIRBP", "CLASP1", "CLUH", "CNN2", "CNOT9", "COPG2", "COPS2", "COPS3", "COTL1", "CPNE1", "CPSF7", "CRTAP", "CSE1L", "CTR9", "CUL1", "CUL2", "CUL4B", "CUL5", "CWF19L1", "CYB5D2", "DCTN1", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC8", "DNAJC9", "DPF2", "DPYSL2", "EEA1", "EEF1B2", "EEF1D", "EEF1E1", "EHD1", "EHD4", "EIF2B4", "EIF3B", "EIF3E", "EIF3L", "EIF3M", "EIF4B", "EIF4G1", "EIF4G2", "EIF5", "EMC1", "EML4", "EPHX2", "EPRS", "EPS15", "EWSR1", "EXO1", "EZR", "FDPS", "FKBP10", "FKBP4", "FKBP5", "FTO", "FUBP1", "FUS", "FXR2", "GAMT", "GAPVD1", "GARS", "GEMIN5", "GGT7", "GNPDA1", "GPS1", "GRB2", "GSTM2", "HEATR3", "HECTD1", "HGH1", "HMGB1", "HMGB3", "HNRNPDL", "HNRNPK", "HNRNPUL2", "HTATSF1", "HUWE1", "IFIT5", "INTS14", "IPO4", "IPO5", "IPO7", "IQGAP1", "IQGAP2", "ITCH", "KDM1B", "KDM2A", "KHDRBS1", "KHSRP", "KIAA0368", "KIFBP", "KPNA6", "KPNB1", "LARP1", "LARP7", "LASP1", "LEMD3", "LGALS3", "LMAN1", "LNPEP", "LTA4H", "MAPRE1", "MAPRE2", "MARC2", "MEPCE", "METTL13", "MFSD5", "MIA3", "MINDY3", "MOGS", "MPP6", "MSH2", "MSN", "MTAP", "MYCBP2", "MYH9", "NAA15", "NAA40", "NASP", "NCAPD2", "NCOA5", "NECAP2", "NHLRC2", "NISCH", "NLN", "NPEPPS", "NRP1", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NUCB1", "NUCB2", "OLA1", "OSBPL9", "OTUB1", "P4HA2", "PABPC4", "PALLD", "PAPSS1", "PCYOX1", "PDCD6", "PDCL3", "PDLIM1", "PDLIM5", "PFAS", "PFDN5", "PFDN6", "PGLS", "PGM1", "PGM3", "PIK3R4", "PIN1", "PITPNA", "PLEC", "PLOD3", "POLA1", "POLR2B", "PPIL3", "PPP2R1A", "PPP6R3", "PQBP1", "PREB", "PRKAR1A", "PRMT1", "PRMT3", "PRMT5", "PRPSAP2", "PSMA4", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD1", "PSMD11", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSME1", "PTPN11", "PUS1", "PWP2", "RAD23B", "RANBP1", "RANBP3", "RANBP9", "RBBP6", "RBM10", "RBM12", "RBM15", "RBM26", "RBM3", "RDX", "RMDN3", "RNF20", "RPA2", "RPAP3", "RPL36A", "RPL37", "RPS19", "S100A11", "S100A13", "SCAF11", "SCAF4", "SEC23A", "SEC24A", "SEL1L", "SENP3", "SEPHS1", "SET", "SETD1A", "SF1", "SF3A2", "SHOC2", "SLC25A20", "SLC25A26", "SLC33A1", "SLC9A3R1", "SMARCAD1", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMYD3", "SNX1", "SNX2", "SNX5", "SPART", "SRI", "SRP72", "SRSF12", "SRSF6", "SSRP1", "STAG2", "STARD7", "STAT3", "STIP1", "STX12", "STXBP4", "SUPT16H", "SUPT6H", "TAF15", "TAGLN2", "TARDBP", "TARS", "TBC1D15", "TBC1D4", "TBCD", "TBCE", "TCERG1", "THUMPD3", "TJP2", "TLN1", "TMOD3", "TNPO1", "TRAPPC4", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRMT2A", "TROVE2", "TSFM", "TTC19", "TXNL1", "UBA3", "UBA6", "UBAP2L", "UBE2M", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBXN1", "UCHL5", "UFC1", "UHRF1", "UNC45A", "USO1", "USP33", "USP48", "USP5", "USP9X", "VBP1", "VCL", "VIRMA", "VPS35", "XPNPEP1", "XPOT", "XRCC6", "YWHAB", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZFYVE16"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..7f7f2e5e4afcf1d45d297e5ed3c04ffe870d0a62 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9032acf2756555b901bf510606ab0c0c9690593046be21b004b23f6446211a17 +size 53925 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..05976d9669b4a5ba3391ed1dafa978b42944e665 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 1.75 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3b0f0470353259ee179611fca7bac132f6b2af63 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..911c0f98110fcfc0055bf4e7c9370c039a6363c6 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e7e622683a6ed303c7d0e188cfc8b199badddd59 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "EIF5A", "FASN", "SLIT2"], "leading_proteins": []} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e279d960bcf486ef125535a3f6c052485e7bbad1 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tetratricopeptide repeat [IPR019734]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..805473163c248955d897199425842778456692a9 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7268a4d16475804991d278e9a996f236eb73b98d6b5204b78830faa19a4b8618 +size 193717 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6d4a23eed8058735f4520830dac6b18859230c65 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tetratricopeptide repeat [IPR019734]", "1": "HEAT, type 2 [IPR021133]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ea248f07fe7f8d48bc263f6253317b3872701528 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9c8c6a33d67081ca85a2d76083b13d2a94b534233e41dfd87da952182def6314 +size 139552 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..513212d51c66e9fb379ddc8dcf9889367f8d7318 --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f723a887c8c34492b23ee905974f22983536657b04f10fc4d21f1f381bad70cd +size 133557 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5a72430d4320f02684615e8cbf3d7f3f04b8db12 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:928ff32dda65aac865ea7ff6225e3456f8de7f00f71d22dbc3a08a62870735a9 +size 60120 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..00205d7697486c5c4b58005a1a9393fabbe86563 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tetratricopeptide repeat [IPR019734] 12 40 2.618399805193864 0.0088343231171785 12.970873786407768 46.12864077669903 0.1542348580007995 0.737058432417436 6.151732427361949 3.0807033456612354 0.6504874091328093 0.2906149179396126 1.0 0.2585034135137037 0.1771228354254465 0.0227781157722808 0.0007461829218621 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..008d80f980beb3217273151be9a6df5be2f895fe --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 64, + "title": "Average number of proteins per term", + "value": 5.40625 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e732f56b30ceed3307ba1c910fa6750c0fba41c2 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..24aa48e7d4729350b527b765a9f30114c9a3be12 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tetratricopeptide repeat [IPR019734] 0.5355489585578694 2.618399805193864 0.0088343231171785 0.433290773576464 0.0759577294402618 40 P49321,Q6DKK2,Q13451,O76094,Q9UJX4,Q9UJX2,Q9H3U1,Q13325,Q6PD62,Q9BXJ9,O15460,Q02790 12 +Tetratricopeptide repeat 1 [IPR001440] 0.4932449350171833 1.0411328585653794 0.2978138913972139 0.9999999998510836 0.6073838107176788 10 Q9H6T3,Q13451,Q02790 3 +Proteasome/cyclosome repeat [IPR002015] 0.7718724448078523 1.01040716080564 0.3123002585164038 0.9999999999607784 0.6073838107176788 2 Q13200 1 +HEAT repeat [IPR000357] 0.6549184101778502 1.008567131152828 0.3131822774013031 0.999999999963871 0.6073838107176788 4 Q8TEX9,O00410 2 +Mitochondrial substrate/solute carrier [IPR018108] 0.4065896659057166 0.8360938878486195 0.4031020866233095 0.9999999999999954 0.6637687479907822 17 Q70HW3,O43772 2 +Tetratricopeptide repeat 2 [IPR013105] 0.5357028413631867 0.5579834160795433 0.5768557086286774 1.0 0.7855056457922416 4 Q13325 1 +HEAT, type 2 [IPR021133] 0.370554986721188 0.4526358550657207 0.6508109758685956 1.0 0.8557036965551285 10 Q8TEX9,P30153,Q86Y56,Q99570,Q14974 5 +Armadillo [IPR000225] 0.3384668291709756 0.3905956764031212 0.6960961220004456 1.0 0.856733688615933 14 Q6NXE6,O60763,Q14974,O60684 4 +Regulator of chromosome condensation, RCC1 [IPR000408] 0.4656345236136789 0.3322114274901586 0.7397296154361019 1.0 0.8705094760650981 4 O75592 1 +Pumilio RNA-binding repeat [IPR001313] 0.4094069529652379 0.0584690594596601 0.9533750072916578 1.0 0.9533750072916578 3 Q86U38,Q14671 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..83ca442126da158ce81822d4d5a16355d08b17c9 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "P120R repeat [IPR012586]", "PQ-loop repeat [IPR006603]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN2", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ASPH", "BIRC6", "BOP1", "BUB3", "CAST", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF8", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DSP", "DST", "DYNC1I2", "EDC4", "EHMT1", "EHMT2", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "GCN1", "GEMIN5", "GLG1", "GLS", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HUWE1", "IFIT5", "IGF2R", "IPO4", "IPO5", "JUP", "KAT7", "KDELC1", "KDELC2", "KDM2A", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LRBA", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "MACF1", "MAP4", "MKI67", "MPDU1", "MPHOSPH8", "MRPS27", "MTCH2", "MYCBP2", "NAA15", "NASP", "NEK9", "NHLRC2", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NUP214", "NUP37", "NXF1", "OGT", "P4HA1", "P4HA2", "PAK1IP1", "PDCD11", "PHIP", "PIK3R4", "PLEC", "PLRG1", "POLR2A", "PPID", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PREB", "PRKCSH", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RBBP5", "RBBP7", "RCC1", "RCC2", "RPAP3", "RRP9", "SART3", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHOC2", "SIN3A", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SRP72", "STIP1", "STRAP", "STUB1", "SUGT1", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "TMTC3", "TOMM34", "TOMM70", "TTC1", "TTC19", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "XAB2", "XPO1"], "leading_proteins": ["ANAPC5", "ARMC6", "CDC23", "CTR9", "DNAAF5", "FKBP4", "FKBP5", "IFIT5", "IPO4", "IPO5", "KPNA6", "KPNB1", "MYCBP2", "NAA15", "NASP", "NOP9", "P4HA2", "PIK3R4", "PPP2R1A", "PSMD2", "PUM1", "RPAP3", "SLC25A20", "SLC25A26", "SRP72", "TTC19", "UNC45A", "USO1"]} \ No newline at end of file diff --git a/msigdb_gobp/advanced/idx2term.json b/msigdb_gobp/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9fba9577f8f6ecf797a94938d32f964bb67c607e --- /dev/null +++ b/msigdb_gobp/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Protein modification by small protein conjugation", "1": "Cytoplasmic translational initiation", "2": "Translational initiation", "3": "Cell cell adhesion", "4": "Nucleoside triphosphate metabolic process", "5": "Protein modification by small protein conjugation or removal", "6": "Negative regulation of protein modification process", "7": "Actin cytoskeleton reorganization", "8": "Cell projection assembly", "9": "Response to wounding"} \ No newline at end of file diff --git a/msigdb_gobp/advanced/plot_0.png b/msigdb_gobp/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2832fe707663d9448275b9650c6476fc4d1c8f6f --- /dev/null +++ b/msigdb_gobp/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protein modification by small protein conjugation 54 132 3.0689610490655186 0.0021480459567089 49.78155339805825 174.4271844660194 -0.3557300534717427 0.6008323663313005 19.786257109481028 23.686402613562866 1.019209592702377 0.3351969355746119 1.0 0.8622419655398812 0.9616276290959632 0.1761078337177914 0.0811462407459992 +Cytoplasmic translational initiation 7 19 3.014708962555695 0.0025722595173365 6.475728155339806 20.56553398058253 -0.04536393433903 0.617661582577164 3.4825352337421975 1.4953249009913971 0.8036287605396817 0.2991791180258557 1.0 0.0738393547118652 0.0162721684360546 0.018305800105915 1.483823238667728e-05 +Nucleoside phosphate catabolic process 0 13 2.796229279830885 0.005170270660721 4.604368932038835 18.655339805825243 0.0962143819400473 0.5415770686805816 3.4056321626088666 2.256091136153212 0.9847714139711842 0.3121628759754123 0.0060808160061114 0.1674341055486001 0.3758826063580091 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1.6504854368932038 6.385922330097087 1.138869139630967 0.2726341581961526 1.2184562719610088 0.8029653015671253 0.9206381175249092 0.2739573544488438 1.0 0.0347606010038453 0.0035377716455847 0.026979757634231 0.1038862441468568 +Deoxyribose phosphate metabolic process 2 11 2.4778470438457103 0.0132177795294032 3.8932038834951457 14.16019417475728 0.2911792764864474 0.4364643181075437 2.7187326479186407 1.955467307187883 1.1552055506656809 0.3084957081652735 0.0033346410356261 0.0954786960097206 0.0270210643166924 0.0371345609925306 0.2070430667536831 +Cell chemotaxis 3 27 2.467561892519103 0.0136036701685329 9.135922330097088 37.060679611650485 -0.0784030605852576 0.6324652441331359 4.405531703007072 4.1435067372718635 0.8456116765533065 0.3122963338427361 1.0 0.0405583573495901 0.0091996052814417 0.2135299832279186 0.3922514276971347 +Negative regulation of protein modification process 25 100 2.447087046460592 0.0144016052707938 30.0873786407767 126.44174757281552 -0.2500879911319606 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0.2975873822729644 1.0 0.0015386759811371 0.0097945170290759 0.069362000240002 0.2362188176745236 +Positive regulation of alpha beta t cell activation 1 8 2.412407800051439 0.0158475450776576 2.529126213592233 8.099514563106796 -0.0124856573652581 0.4973880647677587 1.950012749172222 1.1048435979818627 0.9641870509867974 0.2901167607361103 1.0 0.0030167482455624 0.0187430821816874 0.1234476226975554 0.374416845310929 +Response to wounding 18 58 2.403692778661123 0.0162304069003451 14.859223300970871 77.98300970873787 0.2907833523091244 0.6653892827271913 6.777288412904535 9.76879332264166 0.7686640367654125 0.3260596058790733 1.0 0.0017600571675614 0.0079035266248946 0.0339732958971468 0.0715990617037621 +Pyrimidine containing compound metabolic process 3 20 2.39933409942566 0.0164249207534878 8.009708737864077 27.08252427184466 -0.2756045187145757 0.5434059058486369 4.712604757932364 3.4001692472000644 0.9602027857856432 0.3148010159956353 0.0068654374262982 0.1869550577833588 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44 2.3682741997626 0.017871285485363 11.9126213592233 59.99029126213592 0.1446120400866948 0.6484734112111603 6.210086996743008 7.840330320006731 0.7798797329713693 0.3108096826634549 1.0 0.0005333042365215 0.0018384065569704 0.0684948099465165 0.1922415957763991 +Alpha beta t cell differentiation 2 10 2.361270335629487 0.0182124488333754 3.0145631067961167 10.315533980582524 0.0059961459623565 0.5316576321586325 2.267281326820642 1.2608563341821548 0.931380131474168 0.2953345406530252 1.0 0.0083336110644892 0.0489096908519388 0.2729088009977652 0.3719462319726577 +Positive regulation of ion transport 15 30 2.3600986667406563 0.0182700750528888 9.75242718446602 39.09708737864078 0.1948252561601866 0.6796495505979099 4.075961847535128 4.674376679502791 0.7078649089176284 0.3044976342479915 1.0 1.0 0.5741658022945153 0.2273743922247463 0.000637761940087 +Regulation of alpha beta t cell differentiation 1 7 2.3594820391154125 0.0183004667297004 2.2742718446601944 7.101941747572815 0.0138698526108014 0.4826884102779213 1.7994115013923857 1.076805828700402 1.001566756006478 0.2889592384465417 1.0 0.0028063848659822 0.0174888863239899 0.1162260941127482 0.3575183676904415 +Deoxyribose phosphate catabolic process 0 5 2.342841894277506 0.0191374909507811 1.7572815533980584 7.25 0.4417369759637933 0.3797188803533401 1.5809301638161015 1.1979452473022214 1.1866734243944994 0.2993182794477304 0.0021577089054228 0.0628328620388111 0.1537553372636865 0.3841846627361182 0.6479094034622277 +Vasculature development 13 73 2.333703851595415 0.0196112342773908 20.354368932038835 95.0 -0.2304125656009934 0.6533759527787552 8.394731087929287 11.260378168820724 0.7092119435529696 0.3032836594411232 1.0 0.005504174816198 0.0782068500917938 0.3613246640562453 0.6623860884153977 +Alpha beta t cell activation 3 15 2.3306249121223352 0.0197731466920014 3.929611650485437 14.87378640776699 -0.0179825552641058 0.6028860595762158 2.6259342941410053 1.495492331508811 0.805796546376565 0.2864536339238681 1.0 0.0141859547681839 0.0796471284080524 0.1523398701543102 0.3228399176837545 +Fatty acid transport 2 12 2.326202682260345 0.0200077406511269 4.405339805825243 16.594660194174757 0.9956425124175664 0.363449355794835 2.458050105556273 1.867782713051167 0.7812672834370499 0.2834143639149277 1.0 0.006090286127694 0.0033472839631717 0.0558165767033948 0.282143858544749 +Blood vessel morphogenesis 11 60 2.267541364470645 0.023357175000674 16.385922330097088 77.21116504854369 -0.0973321885149326 0.6747953299436705 6.598329876492682 9.741890907235984 0.7122561449451958 0.2968219097091266 1.0 0.0024229674177942 0.036759020040163 0.4195597955964204 0.6578718136942708 +Pyrimidine nucleotide metabolic process 3 14 2.266854062296402 0.0233991422709203 5.177184466019417 17.638349514563107 -0.1307475953483338 0.4979756361619598 3.6696292020496286 2.5039357745909663 1.090885713459186 0.3200827849412255 0.0042173401333081 0.119238835409784 0.0416480819787975 0.0138989947683802 0.0135641985708927 +Enzyme linked receptor protein signaling pathway 26 90 2.2618937494597287 0.023703968653034 25.24271844660194 117.68932038834951 0.1053848292396163 0.7149684279491084 9.284046259048107 15.168490031291515 0.7848849412953816 0.3313693252810506 1.0 0.4580044198153323 0.3579104044672239 0.3465643426403448 0.2303074339085464 +Transmembrane receptor protein tyrosine kinase signaling pathway 18 56 2.255562486845029 0.0240980447786423 16.08009708737864 77.06067961165049 -0.0485627927051033 0.6938858681640644 6.537486526767104 10.47367052639186 0.6879809976691484 0.2993517001027577 1.0 0.2610275632532581 0.4705086313832701 0.4527877964401487 0.2175695395083626 +Positive regulation of lymphocyte differentiation 1 9 2.2548126915020195 0.0241450883162586 3.145631067961165 9.684466019417476 -0.2392915071178997 0.5232598002814166 2.14931809908948 1.2627798954605274 0.9021091225516048 0.2930856392494232 1.0 0.0070122547778003 0.0416480819787975 0.2404624847217115 0.5983797773200845 +Cilium organization 14 36 2.252837011969758 0.024269427572211 14.691747572815531 55.82281553398058 0.0221375254996847 0.6654254381304918 6.682438210798127 8.24622089584433 0.82651123367483 0.3176216146301823 1.0 1.0 0.6071503012717537 0.2327531801379596 0.3646830805823424 +Sprouting angiogenesis 2 11 2.2351202298088237 0.0254094566090441 2.866504854368932 13.946601941747574 0.1929244500672679 0.5584907474721589 2.165292064758145 2.09531680918901 0.8400779431440976 0.2782785167230157 1.0 0.0007733296576115 0.0113825058930781 0.1523398701543102 0.5525199832161725 +Regulation of fatty acid biosynthetic process 1 7 2.231042670386933 0.0256783026655953 2.7427184466019416 7.657766990291262 -0.2450042309785353 0.5139038450580659 1.6654164726949836 1.4587742108131951 0.9408062932840516 0.3040451215825719 1.0 0.0018638811559655 0.0117927249980906 0.0820001849767809 0.0790760036833716 +2 oxoglutarate metabolic process 1 9 2.229582191048102 0.0257751932364684 3.453883495145631 9.264563106796116 -0.1064110443111423 0.384612626342152 2.2992842841711263 0.7004898101848963 1.2698803823360194 0.3050485324830972 1.0 0.000858130659064 0.0055463544406177 0.0411314896561581 0.1511303325153284 +Protein polyubiquitination 16 38 2.222365941767744 0.0262585850645895 12.611650485436892 49.88592233009709 0.2698122167105246 0.6118505816632617 6.467218320876326 7.957965776185411 0.9830885011877004 0.3433598945202875 1.0 0.4468710257184605 0.7820403471093433 0.2664204621525829 0.1328655371314713 +Protein monoubiquitination 9 18 2.2222967187198366 0.0262632597611176 8.237864077669903 22.237864077669904 -0.6142653714691618 0.4833440558870355 4.35073069423495 2.9767257866168304 0.8998600215815934 0.310815767494152 1.0 0.1965488752384769 0.1074817124453496 0.2180247724103086 0.0546012419267142 +Regulation of lymphocyte differentiation 3 14 2.210998242226394 0.0270359587827504 3.8907766990291264 16.104368932038835 -0.0423411056042451 0.6030145702328973 2.591099848686814 2.1758338073237655 0.832763456907396 0.2974722093375354 1.0 0.0218839190350043 0.1172690102567073 0.5094367246036823 0.4906218398788587 +Chaperone mediated protein folding 9 35 2.210772908155173 0.0270515668077386 11.118932038834952 38.883495145631066 -0.1029907258602878 0.6564055836771622 6.3893062073213605 1.9941709758805528 0.8301601182731878 0.321599905761079 1.0 0.1599975741724837 0.3614400632355885 0.0392513140235194 6.929874120673825e-05 +Deoxyribonucleoside triphosphate metabolic process 1 7 2.1948430162580848 0.0281748606025593 2.3106796116504853 8.283980582524272 0.37885565145774 0.3611791401950917 1.8009119923381658 1.1145270578724225 1.2279981659947377 0.2841942772074602 0.0012750098077396 0.0376040006472809 0.0939009058561071 0.0314345739169305 0.1191519640939084 +Positive regulation of cell differentiation 24 94 2.190304664755345 0.0285021487644128 29.635922330097088 119.78398058252426 -0.3041540147273125 0.652847591220036 13.280340637584493 12.127335554445104 0.6738509424320481 0.3036272393631926 1.0 0.1473243050216857 0.2582064243392279 0.8709980140662615 0.5345524644901777 +Negative regulation of nf kappab transcription factor activity 1 10 2.1805127420556474 0.0292194753620786 5.206310679611651 15.25 -0.1998835372827872 0.5476859152179907 3.059071973715457 2.7805016310709743 0.9055509237440706 0.3070785336486563 1.0 0.1575044921797797 0.3565529630373468 0.3612348793648026 0.7567455769412013 +Negative regulation of developmental process 26 85 2.175143129823135 0.0296193922957124 22.606796116504853 101.0631067961165 -0.1690080981071963 0.631864255638976 9.924264293838888 11.641526693087815 0.7921494883239464 0.3166468220789081 1.0 0.1445614693566743 0.0065942455337756 0.2758609343004218 0.0674943813654425 +Regulation of t cell differentiation 2 11 2.169915811520324 0.0300132242887884 2.8470873786407767 12.138349514563108 0.0637681114317547 0.5892186086676258 2.085180316790378 1.8255961106972616 0.8389380233464193 0.2943208714491699 1.0 0.0150688830138608 0.0841094921706975 0.4078212296470274 0.5742605811238559 +Smad protein signal transduction 2 8 2.1644693583123287 0.0304283457913732 2.9223300970873787 8.470873786407767 1.0610232243819884 0.2706100861951009 1.609675360071813 0.9712499271368484 0.9663464864325269 0.2495327076802485 1.0 1.0 0.0348404027350338 0.0524422164368256 0.2693961077242547 +Tricarboxylic acid metabolic process 1 8 2.161557095225298 0.0306523315760998 3.766990291262136 9.388349514563108 -0.367579777657415 0.3202342688769181 2.323179456329947 0.6306570731062863 1.3940148783056183 0.2966527591969329 1.0 0.0005423652935217 0.0035377716455847 0.026979757634231 0.1038862441468568 +Pyrimidine nucleoside triphosphate metabolic process 2 11 2.15806694261284 0.0309226274725264 3.2402912621359223 12.305825242718448 0.0506614401496208 0.4888226190049212 2.6980805677588324 1.632100632410349 1.0766912351899522 0.3187660552908488 0.0023538642604679 0.0683518202938552 0.1665167759662334 0.0147099971837948 0.0042576023182052 +Positive regulation of calcium ion transport 8 12 2.155551860475289 0.031118674967983 4.37378640776699 16.37135922330097 0.2186920910089725 0.6109357374098573 2.387486030663084 2.3286845941260026 0.7719286404188885 0.2911799674184548 1.0 1.0 1.0 0.6454885854012022 0.0012695246955451 +Regulation of lipid transport 1 10 2.1485484228980747 0.0316702139679379 4.084951456310679 16.67718446601942 0.3665821344953645 0.5500608719110902 2.096012568417446 3.1783802180721676 0.8243482455883206 0.2999534514421824 1.0 0.1674341055486001 0.0796471284080524 0.3924629703223771 0.5525199832161725 +Cellular response to vascular endothelial growth factor stimulus 1 6 2.148372539232448 0.0316841724899461 2.2354368932038833 6.213592233009709 -0.2739927244592021 0.4779011439627239 1.510611833031637 1.687478071411025 1.0023419766853818 0.297801109567981 1.0 0.0044284907330532 0.0270210643166924 0.1687223204737639 0.4713420365340575 +Positive regulation of calcium ion transmembrane transport 7 10 2.147973514230196 0.0317158595713826 3.4757281553398056 11.400485436893204 -0.0406550291907812 0.6126735926929564 2.272010615463777 1.671375155368205 0.7904470259599198 0.2914620210298779 1.0 1.0 1.0 0.5169377862014988 0.0006518646528224 +Cell migration involved in sprouting angiogenesis 2 7 2.130575107167326 0.0331241621315023 1.5024271844660195 7.502427184466019 0.6299354700552533 0.4033822961376643 1.5192914585292825 1.07599307575227 0.9565887314303816 0.280512597606792 1.0 9.774195781334074e-05 0.0015988336703575 0.029242664933406 0.1714275150577477 +Pyrimidine deoxyribonucleotide metabolic process 1 5 2.1301359131417126 0.033160394129942 2.0388349514563107 6.660194174757281 0.1294505442217243 0.4040744110153614 1.7090412352055069 1.2963982821592612 1.1908221881064291 0.2943892670721009 0.0016673205178158 0.0488968448915506 0.0071140696266867 0.0517895754631345 0.1845383204790011 +Skeletal muscle organ development 5 20 2.12415039071316 0.0336575699958241 6.334951456310679 24.08252427184466 0.124533183769639 0.657573298381775 2.981242613729274 3.0190311306539193 0.742964346268656 0.2922652420181553 1.0 0.2246782895335702 0.0270949959938561 0.0393460941113291 0.1028554260325134 +Isocitrate metabolic process 1 5 2.120591310821853 0.0339562099902175 2.3276699029126213 5.495145631067961 -0.2061858290398174 0.3041702034210444 1.4604532504880654 0.4999764345469411 1.4464876184642763 0.300957520728341 1.0 0.0001246264613063 0.0008280259400391 0.0066820689418734 0.0283352150228686 +Negative regulation of immune system process 7 36 2.1104369270333105 0.0348207385809078 10.262135922330096 46.91019417475728 0.2444799455656694 0.6277319776406994 4.757132947946456 7.065174604728879 0.8023664740567815 0.321929768279026 1.0 0.0139270051007782 0.0098110295604543 0.1759792911258833 0.2803408894549661 +Cell projection organization 69 178 2.09337172372651 0.0363159845490901 54.529126213592235 250.1771844660194 0.0885716979556682 0.8002003294890062 21.77302656141916 31.312086500340524 0.7390344422983982 0.3036099690788064 1.0 0.954275566015401 0.481526356601757 0.3286168168607388 0.0377458909556632 +Protein peptidyl prolyl isomerization 6 20 2.093286787876385 0.0363235613512267 5.805825242718447 24.152912621359224 0.2517409431057898 0.5902438884006979 3.2955051837407017 2.757763315973305 0.91993420852781 0.3179002106692878 1.0 0.1008116847670844 0.0300529169697376 0.0001122871568187 0.0001909916414374 +Positive regulation of g1 s transition of mitotic cell cycle 5 12 2.068543188263854 0.038588973842192 4.560679611650485 13.898058252427184 -0.1199565510685006 0.5791815583374341 3.1133454556919187 1.6921566971970388 0.8330981665370115 0.2874869852682005 1.0 0.0981490009795165 0.2333826765186061 0.1765246828365783 0.0049267053225411 +Proteasomal protein catabolic process 42 123 2.065238648129301 0.0389004253654441 37.56553398058252 157.79126213592232 0.1135553068650112 0.7570101769480738 14.502195229082991 14.765320210929556 0.8241107661556262 0.3132494806399983 1.0 1.0 0.087364599204837 0.0330827395225985 0.0080898409043746 +Negative regulation of cell projection organization 10 21 2.064542254673889 0.0389663318762745 6.281553398058253 29.016990291262136 0.4941593335808462 0.5349350626710885 3.4357274091046452 3.2317001852406393 0.8729841284160588 0.3226134265261706 1.0 0.290899946231896 0.2183049536368841 0.2461738423586802 0.1689478612941238 +Negative regulation of neuron projection development 8 14 2.055221552968068 0.0398576102909586 4.944174757281553 19.932038834951456 0.8070712719008988 0.4165241941447024 2.3357271686464363 2.7475042016888107 0.8484003015222881 0.3001902418041021 1.0 0.2130753572147734 0.1247526789063757 0.1000059069748034 0.0805836881433365 +Regulation of leukocyte migration 3 20 2.0547881610585046 0.0398994702028832 6.080097087378641 26.6504854368932 0.4712165673240142 0.5560717407414059 2.980664549328318 3.842679935245632 0.8934424673809059 0.3310773445531978 1.0 0.0012443436923306 0.0022065587688678 0.0745402546504468 0.2487433265210238 +Positive regulation of ion transmembrane transport 10 22 2.051325093418624 0.0402352983536136 6.211165048543689 25.466019417475728 -0.0740930417236195 0.6723652817235894 3.2270957820230888 2.772316454500605 0.7062105093263619 0.2873519548934867 1.0 1.0 1.0 0.4744266113323533 0.0018548131076163 +N terminal protein amino acid acetylation 3 5 2.0445764713686576 0.0408966311104044 1.7621359223300972 5.29126213592233 0.468170205145664 0.4621753504993651 1.4369342030361782 1.0061082182443093 0.9803510996484076 0.3117526403347991 1.0 1.0 0.1075529228767232 0.0038180158699754 0.0041164055854717 +Regulation of protein modification by small protein conjugation or removal 28 68 2.043856787182856 0.0409676972073733 22.805825242718445 81.57281553398059 -0.2234328371977699 0.6375625380201223 10.920550016756897 7.581085228238563 0.846735683730111 0.3135551431840137 1.0 0.445206311717237 0.4428357109236041 0.0040101851879118 0.0020617256686622 +Peptidyl proline modification 9 29 2.0388120171371065 0.0414687924991277 7.95873786407767 32.38106796116505 0.6521103584457676 0.5266525958057561 3.2591538539789924 3.194797169860135 0.931894104733149 0.3508680261875629 1.0 0.0090330503435811 0.0059462173176796 8.327760182189775e-05 1.0969760236260672e-05 +Regulation of fatty acid metabolic process 1 10 2.0382428829992185 0.0415256488403577 3.349514563106796 13.262135922330096 -0.5146147667309706 0.4460510865045744 2.0131062693582926 2.71890599447054 0.932983317929138 0.274795541951318 1.0 0.0086801325317199 0.0507921856702582 0.281021928639471 0.384684662219739 +Positive regulation of hemopoiesis 1 13 2.021250860566929 0.0432538031451095 4.230582524271845 14.929611650485436 -0.2186211661557186 0.5954847741809357 2.6645345411271455 2.4519453035324323 0.7932086928673039 0.2882455125314783 1.0 0.01737719102016 0.0955860143940641 0.4453622717429686 0.6256415025490862 +Negative regulation of ion transmembrane transporter activity 5 10 2.020109146947743 0.0433720672811008 3.817961165048544 11.861650485436892 0.3764600221454999 0.5118077234396127 2.3889648646862596 1.939068236399221 0.964288359393085 0.3191649145735881 1.0 1.0 1.0 0.0371345609925306 0.0042444886183554 +Non motile cilium assembly 5 9 2.0153612160567578 0.0438668150629164 4.055825242718447 12.298543689320388 -0.1105006006002452 0.5897641537829882 2.2553690091685983 2.2242480600322576 0.8583119880066024 0.3022610415396294 1.0 1.0 1.0 0.2972236324054883 0.0270025533563547 +Cellular aldehyde metabolic process 1 17 2.015068154085666 0.0438975084625838 7.91747572815534 20.08252427184466 -0.7938265262942007 0.3375522872688842 4.247556171950748 1.3156951859098711 1.215650778116283 0.3011725166646586 1.0 0.0055091064912584 0.0332133567806245 0.2002411625806742 0.530755599802523 +Response to peptide hormone 21 69 2.0041078325456363 0.0450585105758818 18.364077669902912 85.73543689320388 0.0904961179655992 0.7779840970790936 7.929205623466332 8.99273744478687 0.5567920512146107 0.2749492076978814 1.0 0.1617118829494288 0.0375385951035372 0.285710077768978 0.0047914972616834 +Positive regulation of neuron differentiation 3 8 1.9988560464814027 0.0456239315977888 2.441747572815534 9.097087378640778 0.1489217986910376 0.4752014853635246 2.2799260877069525 1.0636497261494449 1.0912419199569945 0.312731807854903 1.0 0.0076599100776209 0.0452242078621805 0.256676437574733 0.0556143133804788 +Benzene containing compound metabolic process 1 6 1.9978841790853437 0.0457292182427564 2.9029126213592233 5.949029126213592 -0.7825533109688244 0.3431264098941031 1.6473842938981933 0.926850826973976 1.0963824746417352 0.2910074998255683 1.0 0.0290494193324047 0.0730355121895775 0.0189279309569866 0.0752334358856352 +Regulation of actin cytoskeleton reorganization 6 9 1.9972034424813268 0.0458030872624075 2.0315533980582523 9.473300970873789 0.6475812280454123 0.4923555924523734 1.86210928385332 1.4027593392258937 0.8192701360092652 0.3182141228016814 1.0 1.0 1.0 0.3841846627361182 0.0028470075633386 +Odontogenesis 2 9 1.9940042391100457 0.0461515912547234 3.0436893203883497 10.150485436893204 0.0188457924623822 0.6134096503134358 2.086255059987354 2.106779338665241 0.8165250819809797 0.2933225498978621 1.0 0.1550042582095505 0.0688404632475066 0.1271702102204265 0.4954256597063534 +Regulation of low density lipoprotein particle clearance 0 6 1.9932590862813209 0.0462330840365265 1.9878640776699028 5.526699029126213 0.0065330278648292 0.5256138018417175 1.328313150648338 0.7483092766324649 0.9599736511850174 0.3132913959239118 1.0 0.0233055782746608 0.0588625116436255 0.1615257346208235 0.0497467038287706 +Response to estradiol 5 13 1.991225078426773 0.0464561479504774 4.480582524271845 15.609223300970871 -0.1183336658454337 0.5504992412244947 2.9241398453943264 2.3974526081633196 0.8881612224001193 0.295018926126729 1.0 0.1821167152069834 0.4038072867492568 0.1843921964734194 0.0939735889023938 +Cellular ketone metabolic process 3 28 1.9886705743544255 0.0467375759552604 10.182038834951456 34.932038834951456 -0.814674478203921 0.4218863348568564 4.2275526807356005 4.800408833564661 0.942984380377188 0.3181019733869752 1.0 0.0043279458322232 0.0537314881183775 0.1002408523267721 0.4256332760802266 +Regulation of protein deacetylation 3 8 1.9867155338012368 0.0469539294228487 4.225728155339806 13.699029126213592 -0.2469311880077686 0.5912727561979635 2.4662809948418194 2.9024092819463565 0.8008530210451231 0.3000737333176102 1.0 1.0 0.0452242078621805 0.256676437574733 0.1536224858641393 +Regulation of response to wounding 2 13 1.986463070587191 0.0469819294555629 4.351941747572815 17.910194174757283 0.1916937563108336 0.6528179381928949 2.677653137862285 2.7171145748351506 0.6975187302586715 0.2828152410982211 1.0 0.1917657268376814 0.1026761455133997 0.2066661418338308 0.2400113258870825 +Regulation of cell differentiation 41 169 1.9852908280433004 0.0471121239032572 48.99029126213592 210.2038834951456 -0.255449565969206 0.7221919123182192 20.43720913899191 22.37689482058825 0.5557991659315296 0.2848972964606696 1.0 0.2132623994479704 0.0837850734983968 0.6992321846969971 0.194580128522304 +Viral gene expression 9 32 1.9848706566642331 0.0471588638208309 11.274271844660197 37.4126213592233 -0.3452854653179168 0.6429124986571071 5.316216097564451 3.569644936563862 0.6601620789250164 0.2908969710949914 1.0 0.2246782895335702 0.1374715967699724 0.288294905450336 0.0062003850494023 +Positive regulation of neuron death 9 15 1.973116737401023 0.0484822637752926 4.822815533980583 18.094660194174757 -0.0735226270733227 0.5984906146941348 3.2938842763774296 2.75245179866051 0.8261853806708824 0.2896561610038048 1.0 0.144931405556328 0.3315582327860309 0.3214142091315279 0.0347783194837162 +Stress granule assembly 9 14 1.9718641658373333 0.0486251149730652 6.0 15.864077669902912 0.1878667407984194 0.6213561303853748 3.795116944358793 1.6416812580981384 0.8599969043931267 0.3221919365712039 1.0 1.0 1.0 0.102132682364161 0.000795341825074 +Positive regulation of interleukin 2 production 0 6 1.969521434366263 0.048893243668884 2.674757281553398 6.932038834951456 -0.1053422976550913 0.5902875018224084 1.784791111032267 1.083970908526 0.782836901459608 0.2860498113928255 1.0 0.0544951247278899 0.1342507559944097 0.3420560664367884 0.593993152642652 +Formation of translation preinitiation complex 2 7 1.9689150187278532 0.0489628505968757 2.4757281553398056 8.686893203883495 0.3131237638950663 0.5646847920589718 1.7768449194704792 0.8134327704793648 0.7806664512256812 0.2843946436245467 1.0 1.0 0.0730355121895775 0.0189279309569866 0.0092700037665191 +Myeloid leukocyte migration 2 20 1.9670294890835776 0.0491798111850376 6.196601941747573 24.973300970873787 0.137730749742602 0.6535999513618568 3.1092858273424677 2.579185876047506 0.7446488106428547 0.2967340100846558 1.0 0.1869550577833588 0.0157838838392664 0.1954498191835801 0.4078741634928732 +Blood vessel endothelial cell migration 3 19 1.9661350935045292 0.049283007582918 4.536407766990291 22.449029126213592 0.7681724367497832 0.3963490094539818 2.4704338498615206 2.406468634828595 1.0319905271466427 0.3120666413936225 1.0 4.879209159657937e-05 0.0018907552608246 0.0659571450008311 0.4078741634928732 +Dendritic spine development 8 16 1.9613415569976496 0.0498391926010715 7.543689320388349 23.533980582524272 -0.0662850934161216 0.5788040721884481 4.8861339354869315 2.485161923503321 0.8816903143735362 0.3057996790234123 1.0 1.0 1.0 0.481548884635121 0.257555348026997 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3589b53805bfdc21901570c33e261922d7cf0bd5 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 6210, + "title": "Average number of proteins per term", + "value": 15.779871175523349 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..911d7dce7dfad9fd1d86b6158ce91148daeae935 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9acd0bd3c87d56821aa97602d92c29e37cc730cb --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1978 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protein modification by small protein conjugation 0.4255569663162224 3.0689610490655186 0.0021480459567089 0.999998413075554 0.1643699647490268 132 Q9NT62,Q9UBT2,Q7Z6E9,Q16763,Q9UPN9,P48506,Q15386,P19474,Q9UJX4,Q9BUN8,Q9ULT8,O75340,Q86WB0,P30260,Q13155,Q9Y3C8,Q6DKJ4,Q9Y4X5,Q13526,Q9UBV2,P61081,Q6PD62,Q8TBC4,A0AVT1,Q5VTR2,Q14258,P61927,P31689,Q99816,P63208,P45974,Q9Y314,Q9UBV8,Q9NW82,Q9UIQ6,P60953,O60678,O75592,Q93034,Q5T4S7,Q7Z6Z7,Q13867,Q96T88,Q04323,Q12899,Q9UJX2,Q00535,P46777,Q13263,P55786,Q5TAQ9,Q9NVI1,Q96J02,Q14139 54 +Cytoplasmic translational initiation 0.7463085194660212 3.014708962555695 0.0025722595173365 0.99999988682281 0.1643699647490268 19 Q9Y5A9,Q7L2H7,P56537,Q9NR50,P23588,Q04637,P55010 7 +Translational initiation 0.4874267688394968 2.72188994859884 0.0064909754472364 1.0 0.1717796545215014 61 Q92499,P04792,P60228,Q7L2H7,Q92905,P78344,O75822,Q04637,Q6PKG0,P56537,P23588,Q9Y262,P55010,Q7Z478,P55884,P05198,P60842,O15372,Q9Y5A9,Q9UI10,Q9Y6E2,Q9NR50,Q07666 23 +Cell cell adhesion 0.451950101399808 2.629459759699107 0.0085520652568251 1.0 0.1806405620574296 73 Q9NYL9,Q9UQB8,Q9Y624,P04792,P04083,P61586,Q5JRA6,Q06124,Q13630,Q8WX93,P31949,P35241,Q9UDY2,O00151,P41440,P35613,Q9Y490,Q9Y5K6,Q9NUQ9,Q9Y5A9,P17931,Q96J02 22 +Nucleoside triphosphate metabolic process 0.5266084346834345 2.6164007165746286 0.0088862202852746 1.0 0.1864304999039037 42 Q9H773,Q9BZX2,Q9NRF8,P55263,P61586,O00178 6 +Response to increased oxygen levels 0.8773740735855277 2.6108765891160006 0.0090310477514696 1.0 0.1875679148382164 8 Q15904,Q8N511 2 +Protein modification by small protein conjugation or removal 0.3982474622645972 2.56511289570717 0.0103142239444133 1.0 0.2088513601619205 160 Q9NT62,Q9UBT2,Q15018,Q9UNS2,Q7Z6E9,Q16763,Q9UPN9,P48506,Q15386,Q92905,Q9NXR7,P19474,Q9UJX4,P68036,Q9BUN8,Q9ULT8,Q9H4L4,O75340,O94874,Q8TEY7,Q86WB0,P30260,Q13155,Q9Y3C8,Q6DKJ4,Q86VP6,Q9Y4X5,Q13526,Q96MG7,Q9Y5K5,Q9UBV2,P61081,P61201,Q6PD62,Q8TBC4,A0AVT1,Q5VTR2,P61927,Q14258,Q15020,P31689,Q9H8M7,Q99816,P63208,Q9UBW8,P45974,Q9Y314,Q9UBV8,Q9NW82,Q9UIQ6,P60953,O60678,O75592,Q93034,Q5T4S7,Q99627,Q7Z6Z7,Q13867,Q96FW1,Q86UV5,Q96T88,Q04323,Q12899,Q9UJX2,Q00535,P46777,Q13263,P55786,Q5TAQ9,Q9NVI1,Q96J02,Q14139 72 +Long chain fatty acid transport 0.794908824404741 2.5199604126942963 0.0117368033452569 1.0 0.2132551479353632 10 O43772,P04083 2 +Cellular response to increased oxygen levels 0.9185768459579822 2.5096006506222084 0.012086776497675 1.0 0.2153706133263397 6 Q15904 1 +Deoxyribose phosphate metabolic process 0.7615951996090783 2.4778470438457103 0.0132177795294032 1.0 0.2153706133263397 11 Q9H773,P34896 2 +Cell chemotaxis 0.586422608025218 2.467561892519103 0.0136036701685329 1.0 0.2166122865297165 27 P14174,P04792,P04083 3 +Negative regulation of protein modification process 0.4041253425191912 2.4470870464605916 0.0144016052707938 1.0 0.2249553162478914 100 P04792,P48506,P19474,Q12824,Q9H7B4,Q04637,P23381,Q01105,Q13363,O43768,Q15257,O75718,P61927,P61964,Q99816,O60678,Q96B36,P11413,Q13148,O95684,Q04323,P17931,P0DP25,Q00535,P46777 25 +Actin cytoskeleton reorganization 0.6213711410900526 2.4295491035686556 0.0151176169548468 1.0 0.2284194678579044 21 P35579,P15311,Q9UQB8,Q9Y624,P62993,Q14247,P52565,P04083,O14786,Q00535,Q9Y5K6,P61586,P11233 13 +Cell projection assembly 0.4346244719939611 2.4139989699665914 0.0157785069664928 1.0 0.2312676195885533 69 Q9NT62,Q14203,O14786,O15144,P11233,A6NIH7,Q15555,P35241,Q8NCA5,Q9NQW6,Q9NR77,Q8TC07,P35609,P15311,P18085,P51116,Q9H4M9,Q9H223,Q9UBB4,P50570,O14745,Q9P258,Q9Y5K6,P27695,P20339,O00471,Q15691 27 +Positive regulation of alpha beta t cell differentiation 0.8944410708257469 2.413960959721227 0.0157801530761996 1.0 0.2312676195885533 6 P04083 1 +Positive regulation of alpha beta t cell activation 0.8304561315325624 2.412407800051439 0.0158475450776576 1.0 0.2312676195885533 8 P04083 1 +Response to wounding 0.4654218833866782 2.403692778661123 0.0162304069003451 1.0 0.2312676195885533 58 O43633,Q9Y624,P04792,Q99439,Q13247,Q99707,P11047,P04179,P04083,P38435,Q13310,Q00535,Q9Y490,P61586,Q96AY3,Q92766,Q5JRA6,Q96G23 18 +Pyrimidine containing compound metabolic process 0.6221504758320912 2.39933409942566 0.0164249207534878 1.0 0.2312676195885533 20 Q9H773,P34896,Q9NRF8 3 +Regulation of alpha beta t cell activation 0.7403415804345228 2.376184353436438 0.0174927206591508 1.0 0.2312676195885533 11 P61586,P04083 2 +Negative regulation of cell differentiation 0.4390261808978581 2.3723774676761025 0.0176740243136137 1.0 0.2312676195885533 65 Q96T37,Q8N4Q0,P04179,P04083,Q99873,P61586,Q06124,O60271,Q8WX92,Q6PD62,Q9UPY3,Q13247,Q92688,Q9NYV4,Q9P258,Q96G23,P11413,Q9Y5A9,Q8N0X7,P40763,Q00535,O14744,O15347 23 +Nadp metabolic process 0.7057112741097327 2.372053017196865 0.0176895522229569 1.0 0.2312676195885533 14 P48735 1 +Wound healing 0.4944217616641677 2.3682741997626 0.017871285485363 1.0 0.2326639053754818 44 O43633,P04792,Q99439,Q13247,P04083,P61586,Q96AY3,Q5JRA6 8 +Alpha beta t cell differentiation 0.7604727053462004 2.361270335629487 0.0182124488333754 1.0 0.2356235567817951 10 P61586,P04083 2 +Positive regulation of ion transport 0.5585845418528909 2.3600986667406563 0.0182700750528888 1.0 0.23577987218141 30 P28161,P14174,P11413,P55011,P27695,P30626,P17931,Q07812,Q15042,Q00535,P50570,P54652,P0DP25,O14745,P35609 15 +Regulation of alpha beta t cell differentiation 0.8535489344999161 2.3594820391154125 0.0183004667297004 1.0 0.23577987218141 7 P04083 1 +Vasculature development 0.4256024024245177 2.333703851595415 0.0196112342773908 1.0 0.2468004608971943 73 O75340,Q9H2J4,P04792,Q96T37,Q9BXJ9,P04179,P04083,Q92688,P35613,P40763,P61586,Q96AY3,Q5JRA6 13 +Alpha beta t cell activation 0.6855081873822959 2.3306249121223352 0.0197731466920014 1.0 0.2475629858010668 15 P61586,Q96J02,P04083 3 +Fatty acid transport 0.7195079815323104 2.326202682260345 0.0200077406511269 1.0 0.2489941271412796 12 O43772,P04083 2 +Blood vessel morphogenesis 0.4458282856258971 2.2675413644706452 0.023357175000674 1.0 0.2805773350572483 60 O75340,Q9H2J4,P04792,Q96T37,Q9BXJ9,P04083,P35613,P40763,P61586,Q96AY3,Q5JRA6 11 +Pyrimidine nucleotide metabolic process 0.6854517595452861 2.266854062296402 0.0233991422709203 1.0 0.2805773350572483 14 Q9H773,P34896,Q9NRF8 3 +Enzyme linked receptor protein signaling pathway 0.4045521216701508 2.2618937494597287 0.023703968653034 1.0 0.2819954891481635 90 P04792,Q9UQB8,P16949,P43490,Q9UQ13,Q06124,O75340,P62993,Q9Y5X3,O00400,Q13526,Q9H1E3,Q9Y2U8,P53999,Q99816,O14745,Q9UIQ6,Q6Y7W6,Q93034,Q96B36,P27695,Q15942,P49354,P40763,Q8N0X7,P11802 26 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.4561503169056419 2.2555624868450295 0.0240980447786423 1.0 0.2839636775623694 56 O75340,Q96B36,Q9H1E3,P11802,Q9UQB8,P04792,P62993,Q99816,P27695,P16949,Q9Y5X3,P43490,P40763,O14745,Q9UQ13,Q6Y7W6,Q93034,Q06124 18 +Positive regulation of lymphocyte differentiation 0.7597228100213769 2.2548126915020195 0.0241450883162586 1.0 0.2839791637196325 9 P04083 1 +Cilium organization 0.515026768915128 2.252837011969758 0.024269427572211 1.0 0.2849019758476951 36 Q9NT62,P18085,A6NIH7,Q15555,P27695,Q9H4M9,Q14203,Q9BW83,O00471,Q15691,Q9H223,Q9UBB4,O14745,Q8TC07 14 +Sprouting angiogenesis 0.7112674794458993 2.2351202298088233 0.0254094566090441 1.0 0.2941481408946985 11 P61586,P04083 2 +Regulation of fatty acid biosynthetic process 0.8227150811730843 2.2310426703869335 0.0256783026655953 1.0 0.2958483479653934 7 P02656 1 +2 oxoglutarate metabolic process 0.754188214204875 2.229582191048102 0.0257751932364684 1.0 0.2964147222193876 9 P48735 1 +Protein polyubiquitination 0.5001440791800631 2.2223659417677437 0.0262585850645895 1.0 0.2980685154259689 38 P30260,Q7Z6Z7,P63208,Q16763,Q13867,Q15386,Q9Y4X5,P19474,Q9UJX4,Q9UJX2,Q9UIQ6,Q5VTR2,Q9ULT8,P55786,Q96J02,Q14139 16 +Protein monoubiquitination 0.6242451038523353 2.2222967187198366 0.0262632597611176 1.0 0.2980685154259689 18 O75340,Q99816,P63208,Q96T88,Q9UBV8,P19474,Q5VTR2,Q6PD62,Q14258 9 +Regulation of lymphocyte differentiation 0.6747916077894311 2.210998242226394 0.0270359587827504 1.0 0.3018580388612118 14 Q9BXW9,P61586,P04083 3 +Chaperone mediated protein folding 0.514969519137994 2.210772908155173 0.0270515668077386 1.0 0.3018580388612118 35 Q9H2J4,P04792,Q13451,O00273,O14737,P25685,P54652,O75718,Q02790 9 +Deoxyribonucleoside triphosphate metabolic process 0.8141067198962292 2.1948430162580848 0.0281748606025593 1.0 0.3058844131851287 7 Q9H773 1 +Positive regulation of cell differentiation 0.3937620280598025 2.1903046647553452 0.0285021487644128 1.0 0.3074188785023309 94 Q8WUJ1,Q9UQB8,Q9Y624,P78344,P04083,P04179,O14786,Q99873,Q04637,P61586,O60271,Q86X55,Q9UPY3,Q15014,Q96A49,Q9H3U1,P50570,Q92766,Q99829,P27695,P40763,P17931,O14744,Q15418 24 +Negative regulation of nf kappab transcription factor activity 0.7220219164756739 2.1805127420556474 0.0292194753620786 1.0 0.3123114320112025 10 P19474 1 +Negative regulation of developmental process 0.4030504581266707 2.175143129823135 0.0296193922957124 1.0 0.3157465490565722 85 Q96T37,Q8N4Q0,P04179,P04083,Q99873,P61586,Q06124,P14174,O60271,P26196,Q8WX92,Q6PD62,Q9UPY3,P16989,Q13247,Q92688,Q9NYV4,Q9P258,Q96G23,P11413,Q9Y5A9,Q8N0X7,P40763,Q00535,O14744,O15347 26 +Regulation of t cell differentiation 0.6979861441504798 2.169915811520324 0.0300132242887884 1.0 0.3182059057396648 11 P61586,P04083 2 +Smad protein signal transduction 0.7733758733175714 2.1644693583123287 0.0304283457913732 1.0 0.3182059057396648 8 P53999,O00400 2 +Tricarboxylic acid metabolic process 0.7727149976271511 2.161557095225298 0.0306523315760998 1.0 0.3182059057396648 8 P48735 1 +Pyrimidine nucleoside triphosphate metabolic process 0.6955830585087375 2.15806694261284 0.0309226274725264 1.0 0.3182059057396648 11 Q9H773,Q9NRF8 2 +Positive regulation of calcium ion transport 0.6853608230981922 2.155551860475289 0.031118674967983 1.0 0.3182059057396648 12 P11413,P27695,P30626,P17931,P0DP25,Q00535,P54652,P28161 8 +Regulation of lipid transport 0.7153043328473906 2.1485484228980747 0.0316702139679379 1.0 0.3182059057396648 10 P02656 1 +Cellular response to vascular endothelial growth factor stimulus 0.8288185047945595 2.148372539232448 0.0316841724899461 1.0 0.3182059057396648 6 P04792 1 +Positive regulation of calcium ion transmembrane transport 0.7151837291009426 2.147973514230196 0.0317158595713826 1.0 0.3182059057396648 10 P11413,P27695,P30626,P0DP25,Q00535,P54652,P28161 7 +Cell migration involved in sprouting angiogenesis 0.7989096130927311 2.130575107167326 0.0331241621315023 1.0 0.3258323537135132 7 P61586,P04083 2 +Pyrimidine deoxyribonucleotide metabolic process 0.8687318441470138 2.1301359131417126 0.033160394129942 1.0 0.3258323537135132 5 Q9H773 1 +Skeletal muscle organ development 0.5778814059482296 2.1241503907131594 0.0336575699958241 1.0 0.3286375938271508 20 P16989,Q9Y281,P41440,P80723,P61586 5 +Isocitrate metabolic process 0.8663305581196388 2.120591310821853 0.0339562099902175 1.0 0.3305142069580735 5 P48735 1 +Negative regulation of immune system process 0.4972738208405922 2.1104369270333105 0.0348207385809078 1.0 0.3368462826722175 36 P14174,Q9Y5A9,P04083,P19474,P28070,Q5JRA6,Q96J02 7 +Cell projection organization 0.370566063648552 2.09337172372651 0.0363159845490901 1.0 0.3431594472031088 178 Q9NT62,Q9UQB8,Q15428,Q14203,O60828,P78344,O60749,P00374,P16949,O14786,O15144,Q99873,P61586,P08670,P11233,P33176,Q06124,P35579,Q8TEY7,Q8WX93,A6NIH7,Q15555,Q04917,O60271,Q14247,Q99707,P35241,Q9BUP0,Q9BW83,Q86X55,Q9NQW6,Q8NCA5,Q9Y296,Q9UPY3,Q9NR77,Q8TC07,A0AVT1,P35609,O95372,Q02790,P55145,P15311,P18085,P61964,Q9Y5Y2,P41440,Q9H4M9,P51116,P35613,Q9H223,Q9UBB4,O14745,P50570,Q9P258,O60678,O75592,Q96G23,Q92766,Q9Y5K6,Q99829,P27695,P20339,O95684,P11047,O00471,Q15691,Q8N0X7,Q00535,O75312 69 +Protein peptidyl prolyl isomerization 0.5729960740908273 2.0932867878763854 0.0363235613512267 1.0 0.3431594472031088 20 Q9H2H8,Q13526,Q15257,Q96AY3,Q9Y3C6,Q02790 6 +Positive regulation of g1 s transition of mitotic cell cycle 0.6681968443322149 2.068543188263854 0.038588973842192 1.0 0.3571349143964422 12 P27695,P04083,O43660,Q7L2J0,Q04637 5 +Proteasomal protein catabolic process 0.3543464355069707 2.065238648129301 0.0389004253654441 1.0 0.3594816094038811 123 Q92530,Q16763,P48506,P48556,Q9UJX4,Q13200,Q9BUN8,Q9ULT8,P25789,Q9NXV2,P30260,P25787,P49721,Q9Y4X5,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q9NRR5,P54727,Q14258,Q99436,Q9UNZ2,P63208,P46379,P45974,P51665,O15372,Q9Y5K6,P20618,Q93034,Q04323,Q5VYK3,Q9UJX2,P60900,Q15008,Q5TDH0,Q06323,Q96J02,Q14139 42 +Negative regulation of cell projection organization 0.5636474347375804 2.064542254673889 0.0389663318762745 1.0 0.3595556031971245 21 Q9NR77,Q86X55,Q8N0X7,O14786,Q00535,P50570,P61586,P08670,Q96G23,Q02790 10 +Negative regulation of neuron projection development 0.6454001824476511 2.0552215529680677 0.0398576102909586 1.0 0.3659907089511148 14 Q86X55,Q8N0X7,O14786,Q00535,P61586,Q9NR77,Q96G23,Q02790 8 +Regulation of leukocyte migration 0.5669235430141363 2.0547881610585046 0.0398994702028832 1.0 0.3659907089511148 20 P61586,Q5JRA6,P04083 3 +Positive regulation of ion transmembrane transport 0.5565373576908992 2.051325093418624 0.0402352983536136 1.0 0.3679840983445369 22 P50570,P11413,P27695,P30626,P0DP25,Q00535,O14745,P54652,P28161,P35609 10 +N terminal protein amino acid acetylation 0.8472917003818504 2.0445764713686576 0.0408966311104044 1.0 0.3695266749975889 5 Q5VZE5,P41227,Q86UY6 3 +Regulation of protein modification by small protein conjugation or removal 0.4019540502017832 2.0438567871828557 0.0409676972073733 1.0 0.3695266749975889 68 Q9UBT2,Q16763,P48506,P19474,P68036,Q9BUN8,O75340,O94874,Q13155,Q6DKJ4,Q13526,Q96MG7,Q5VTR2,Q6PD62,P61927,P31689,P63208,Q9UBV8,Q9NW82,O60678,O75592,Q7Z6Z7,Q96FW1,Q04323,Q00535,P46777,Q9NVI1,Q96J02 28 +Peptidyl proline modification 0.5184816458505248 2.0388120171371065 0.0414687924991277 1.0 0.3696146726200064 29 Q9H2H8,Q13451,Q13526,Q15257,O75718,Q96AY3,Q9Y3C6,O15460,Q02790 9 +Regulation of fatty acid metabolic process 0.692302574722208 2.0382428829992185 0.0415256488403577 1.0 0.3696146726200064 10 P02656 1 +Positive regulation of hemopoiesis 0.6492653325339367 2.021250860566929 0.0432538031451095 1.0 0.3788520698605502 13 P04083 1 +Negative regulation of ion transmembrane transporter activity 0.6885471519835341 2.020109146947743 0.0433720672811008 1.0 0.3793458596121603 10 Q9Y376,P30626,P0DP25,O14745,P28161 5 +Non motile cilium assembly 0.7078200221590663 2.0153612160567578 0.0438668150629164 1.0 0.3823331382225048 9 Q15555,P27695,Q14203,O00471,Q15691 5 +Cellular aldehyde metabolic process 0.6028200022064141 2.015068154085666 0.0438975084625838 1.0 0.3823331382225048 17 P48735 1 +Response to peptide hormone 0.3982453800073008 2.0041078325456363 0.0450585105758818 1.0 0.3897121875713457 69 Q9UQB8,P48506,P04083,P43490,Q06124,O60343,P07741,P62993,P56537,Q9Y5X3,P35609,Q9H1E3,Q13247,P09960,P35613,Q96A49,P27695,Q9UI10,Q9NR50,P40763,P11802 21 +Modified amino acid transport 0.9067103109656256 2.002908794066071 0.0451870790062614 1.0 0.3899639951995856 4 O43772,P41440,O14745 3 +Positive regulation of neuron differentiation 0.7361254657011382 1.9988560464814027 0.0456239315977888 1.0 0.3924163645737797 8 Q8WUJ1,Q99829,P61586 3 +Benzene containing compound metabolic process 0.792489530553716 1.9978841790853432 0.0457292182427564 1.0 0.3927779326245055 6 P34913 1 +Regulation of actin cytoskeleton reorganization 0.7039388979540355 1.9972034424813268 0.0458030872624075 1.0 0.3928690219607057 9 Q9Y624,Q9UQB8,P52565,O14786,Q00535,Q9Y5K6 6 +Odontogenesis 0.7032558465505672 1.9940042391100457 0.0461515912547234 1.0 0.3941156813831491 9 P61586,P35613 2 +Response to estradiol 0.6435400683152922 1.991225078426773 0.0464561479504774 1.0 0.3941156813831491 13 P04083,O95831,O15143,P40763,O75592 5 +Cellular ketone metabolic process 0.5150999279207064 1.9886705743544255 0.0467375759552604 1.0 0.3952180085389472 28 P02656,Q06136,P04083 3 +Regulation of protein deacetylation 0.733420530083015 1.9867155338012368 0.0469539294228487 1.0 0.3952180085389472 8 Q13363,P61964,Q9ULX6 3 +Regulation of response to wounding 0.6426336546694043 1.986463070587191 0.0469819294555629 1.0 0.3952180085389472 13 Q13247,P04083 2 +Regulation of cell differentiation 0.362774562990232 1.9852908280433004 0.0471121239032572 1.0 0.3952180085389472 169 Q8WUJ1,Q9UQB8,Q96T37,Q9Y624,Q8N4Q0,P04179,P04083,Q08J23,Q99873,P61586,Q04637,Q06124,O60271,P26196,P56537,Q8WX92,Q6PD62,Q9UPY3,O15047,Q15014,Q13247,Q92688,Q96A49,Q9C0B1,Q9H3U1,Q9NYV4,Q9P258,Q92766,Q96G23,Q99829,P11413,Q9Y5A9,P27695,Q9BXW9,Q8N0X7,P40763,P17931,Q00535,O14744,O15347,Q96J02 41 +Viral gene expression 0.4997462741727806 1.9848706566642331 0.0471588638208309 1.0 0.3952180085389472 32 Q9H1E3,P61009,Q13148,P55884,P56537,P19474,Q99873,Q12824,O14646 9 +Positive regulation of neuron death 0.6195669860944797 1.973116737401023 0.0484822637752926 1.0 0.4046705081244183 15 Q13155,O95831,Q07812,Q00535,P61081,P05198,P78362,P61586,P17655 9 +Stress granule assembly 0.6298673979161392 1.9718641658373333 0.0486251149730652 1.0 0.4053180724600468 14 Q8N543,Q9Y5A9,Q9Y520,Q8WWM7,P26196,P05198,Q14011,Q14157,O75534 9 +Formation of translation preinitiation complex 0.7611483355751617 1.9689150187278537 0.0489628505968757 1.0 0.4057173565545072 7 P23588,P55010 2 +Myeloid leukocyte migration 0.5531669448295221 1.9670294890835776 0.0491798111850376 1.0 0.4066159958916253 20 P14174,P04083 2 +Blood vessel endothelial cell migration 0.567294792891284 1.9661350935045296 0.049283007582918 1.0 0.4066159958916253 19 P61586,P04792,P04083 3 +Dendritic spine development 0.606422020104207 1.9613415569976496 0.0498391926010715 1.0 0.4100129713180167 16 P18085,Q9UQB8,Q96HC4,P78344,Q00535,P60953,A0AVT1,O60678 8 +Small gtpase mediated signal transduction 0.4042719104492304 1.9576967022939915 0.0502656124370215 1.0 0.4128961021612484 64 P02656,Q9Y624,Q9Y2I1,P16949,Q8N6T3,O14786,Q9UQ13,P61586,Q15555,P62993,P35241,Q15392,Q02818,P41440,P52565,P50570,Q92766,Q9Y5K6,Q9NUQ9,P80303,Q13263 21 +Regulation of lipid catabolic process 0.8247733651085765 1.9539042329528116 0.0507125438896236 1.0 0.4160170377206907 5 P02656 1 +Negative regulation of leukocyte cell cell adhesion 0.6456075453469935 1.952804409406533 0.0508427758629737 1.0 0.4165351426240985 12 Q5JRA6,P04083 2 +Positive regulation of vasculature development 0.6151096885577199 1.9484681649152735 0.0513589704548529 1.0 0.4196568506903115 15 O75340,Q9H2J4,P04792 3 +Monocarboxylic acid transport 0.7560516170933282 1.9468846290939377 0.0515485678313796 1.0 0.4206525706082358 7 O95563,P14174,P04083 3 +Positive regulation of cation channel activity 0.7510996483767325 1.9254329849269312 0.0541752123401204 1.0 0.429804123113342 7 P28161,P0DP25,Q00535,P27695 4 +Cellular response to corticosteroid stimulus 0.648426760935791 1.922450646910077 0.0545490779624708 1.0 0.431528374709483 11 Q9H7B4,P04083 2 +Glyoxylate metabolic process 0.9975470155355683 1.9195633405162775 0.0549130783563431 1.0 0.433303960092619 2 P48735 1 +Regulation of tube size 0.6868046873228266 1.916633905620507 0.0552844574127799 1.0 0.4336883348056639 9 Q9HB40,P04179,P61586 3 +Response to zinc ion 0.8837135463432447 1.9143531221754964 0.0555750510350554 1.0 0.4344775944807355 4 P09960,P04179 2 +Positive regulation of histone h3 k4 methylation 0.6464551857793405 1.9124740044877948 0.0558154238076105 1.0 0.4354444495543483 11 Q6PD62,P61964 2 +Dna catabolic process endonucleolytic 0.7711913794972821 1.9085504407828644 0.0563201103351334 1.0 0.4388304707417546 6 O95831,O00273,P27695,Q9UPY3 4 +Fatty acid biosynthetic process 0.5129607044878892 1.9059767286433809 0.0566532249876388 1.0 0.4403210602919111 26 P02656,P14174,P04083 3 +Regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.7139942024960221 1.8990813529158828 0.0575537804407013 1.0 0.4431866843149862 8 P04792 1 +Insulin receptor signaling pathway 0.5540026846723423 1.8833709868359036 0.0596501093729635 1.0 0.4509100136417803 19 Q9H1E3,Q9UQB8,P62993,Q9Y5X3,P43490,Q06124 6 +Developmental pigmentation 0.7649020264615478 1.8820183253203924 0.0598335275526689 1.0 0.4509100136417803 6 Q96AX1,Q9BXS5,P04179,O43747 4 +Regulation of translational initiation 0.4594425153001581 1.8811057744291495 0.0599575316634926 1.0 0.4509100136417803 38 Q92499,Q9Y5A9,P04792,Q07666,P60228,Q6PKG0,Q7Z478,P55884,P78344,Q9Y6E2,P23588,Q13217,P05198,Q04637,O15372,O75534,P55010 17 +Regulation of small gtpase mediated signal transduction 0.5032702324684658 1.8796978098676704 0.0601492742493556 1.0 0.4509100136417803 27 P02656,Q9NUQ9,Q15555,Q9Y624,P41440,P35241,P52565,P16949,Q8N6T3,Q9UQ13,Q9Y5K6 11 +Granulocyte chemotaxis 0.6303919354900113 1.8740819067838703 0.0609191367133461 1.0 0.4509100136417803 12 P04083 1 +Arachidonic acid secretion 0.986099754701554 1.8738368141577009 0.0609529205680332 1.0 0.4509100136417803 2 P04083 1 +Icosanoid transport 0.986099754701554 1.8738368141577009 0.0609529205680332 1.0 0.4509100136417803 2 P04083 1 +Regulation of ras protein signal transduction 0.5342773281431841 1.8735092547987775 0.0609980959650919 1.0 0.4509100136417803 21 P02656,Q15555,Q9Y624,P41440,P35241,P52565,P16949,Q8N6T3,Q9UQ13 9 +Copii coated vesicle cargo loading 0.7390968438143956 1.873248229923255 0.0610341151031388 1.0 0.4509100136417803 7 Q5JRA6 1 +Lipoprotein localization 0.9856909239574818 1.8722014643988505 0.0611787365794742 1.0 0.4509100136417803 2 Q5JRA6 1 +Regulation of muscle organ development 0.8042325319944602 1.8704939631388455 0.0614152545399231 1.0 0.4509100136417803 5 P16989 1 +Cellular response to osmotic stress 0.676830687670334 1.8694334671669095 0.0615625320443089 1.0 0.4509100136417803 9 P35237,P16989 2 +Response to fungus 0.803105956590887 1.8659004944433664 0.0620552884237999 1.0 0.4509100136417803 5 P81605 1 +Defense response to fungus 0.803105956590887 1.8659004944433664 0.0620552884237999 1.0 0.4509100136417803 5 P81605 1 +Endothelial cell migration 0.5009219879901169 1.862608437343308 0.0625173764080864 1.0 0.4509100136417803 27 O75340,P04792,P04083,P61586,Q5JRA6 5 +Positive regulation of calcium ion transmembrane transporter activity 0.7359034449950437 1.8593197423615169 0.0629818302531379 1.0 0.4521585732624125 7 P54652,P28161,P0DP25,P27695 4 +Negative regulation of cell adhesion 0.5116214497784493 1.855927791809823 0.0634638510263576 1.0 0.4548239706446813 25 Q9Y5A9,P35241,P52565,P04083,P17931,P61586,Q9P258,Q5JRA6,Q96J02,Q06124 10 +Regulation of small molecule metabolic process 0.4456790208738229 1.8521396354227735 0.0640057742499158 1.0 0.4568688024045715 40 P02656,P34913,P04083 3 +Rna mediated gene silencing by inhibition of translation 0.797681977879889 1.843758164403693 0.0652183921616489 1.0 0.4598594313445584 5 Q04637,P40763,P56537 3 +Granulocyte migration 0.6061221017001341 1.8431071438727165 0.0653133685098068 1.0 0.4598594313445584 14 P04083 1 +Positive regulation of release of sequestered calcium ion into cytosol 0.7542638075016213 1.8369866869729743 0.0662118607548643 1.0 0.4603252224076358 6 P30626,P0DP25,P27695,P28161 4 +Positive regulation of calcium ion transport into cytosol 0.7542638075016213 1.8369866869729743 0.0662118607548643 1.0 0.4603252224076358 6 P30626,P0DP25,P27695,P28161 4 +Proton transporting two sector atpase complex assembly 0.9742436631234672 1.826351119710803 0.0677973896626329 1.0 0.4657320683683081 2 Q8N511 1 +Homotypic cell cell adhesion 0.5926389072351635 1.8233269972268216 0.0682538797480063 1.0 0.4673084317572092 15 P04792 1 +Cellular response to acid chemical 0.6277645019147344 1.8174158854663056 0.0691534571786192 1.0 0.4673084317572092 11 Q9UQB8,Q99729,P48506,P17655,O00410,Q6IAA8 6 +Secondary alcohol metabolic process 0.4701093315270579 1.8169101074751577 0.0692308787788458 1.0 0.4673084317572092 34 P48735,P34913,O75874,Q15392,P22570,Q9BQE5 6 +Negative regulation of lipase activity 0.8583373931712502 1.815833456762863 0.0693959233956302 1.0 0.4676178884077919 4 P02656 1 +Leukocyte homeostasis 0.7490380065127762 1.8147964492744253 0.0695551962808436 1.0 0.4676178884077919 6 P04083 1 +Rho protein signal transduction 0.5430457018676682 1.81467786135676 0.0695734291832046 1.0 0.4676178884077919 19 P61586,P02656 2 +Nucleobase biosynthetic process 0.5908551778302763 1.8133322392677875 0.069780593724642 1.0 0.4676178884077919 15 P07741,Q05682,P34896,Q9NRF8,P11172,P17812 6 +Negative regulation of immune response 0.5293443763884724 1.813331093270201 0.0697807703716741 1.0 0.4676178884077919 20 P19474,P04083 2 +Regulation of lipase activity 0.6266683221671152 1.8118145279929103 0.0700148595485119 1.0 0.4676178884077919 11 P02656,P04083 2 +Negative regulation of phagocytosis 0.7475635084487726 1.8085271701408177 0.070524492038329 1.0 0.4689048132312881 6 Q99439 1 +Response to ionizing radiation 0.4765700446629513 1.805175591539756 0.0710472091849607 1.0 0.4709200597011882 32 Q9H1E3,P62993,P29692,P04179,P04083,Q9BXW9,Q9NXR7,Q92547,P43246 9 +Regulation of cellular ketone metabolic process 0.6163961519292155 1.8011493444608184 0.0716793440087548 1.0 0.4735411981854975 12 P02656 1 +Positive regulation of viral life cycle 0.7222343791943351 1.7994935908855982 0.0719406368372113 1.0 0.4737554133182208 7 Q99816,P19474,O60684 3 +Ras protein signal transduction 0.427108895143725 1.7976922622070128 0.0722257883087473 1.0 0.4746416299666239 47 P02656,Q15555,Q9Y624,P41440,P62993,Q9Y2I1,P35241,Q15392,P52565,P16949,Q8N6T3,O14786,Q13263,P50570,Q9UQ13,P61586,Q92766 17 +Positive regulation of protein kinase a signaling 0.9652493867538844 1.79024736839182 0.0734141532041383 1.0 0.4770825722462548 2 P14174 1 +Negative regulation of mrna metabolic process 0.4322270085097102 1.7887188672538703 0.0736601028523875 1.0 0.47748354771746 42 Q99729,Q9Y2W1,P67809,P98175,Q8WXF0,Q14011,O00267,Q6PKG0,Q12872,Q5VTR2,Q6PD62,P16989,P61978,P38159,Q13247,P35637,Q13148,O00422,Q92804 19 +Positive regulation of phosphoprotein phosphatase activity 0.7837999594468812 1.7868896537576109 0.0739553250504525 1.0 0.4788973603371328 5 Q15257 1 +Protein kinase a signaling 0.7422650019780419 1.7859697295929624 0.0741041594744764 1.0 0.4793612816005196 6 P14174,P35241,Q02952 3 +Neuron projection regeneration 0.7187100150261678 1.784015058288535 0.0744212183233352 1.0 0.4797544742885926 7 Q99707,P11047,Q96G23 3 +Negative regulation of lymphocyte differentiation 0.7830210498546621 1.783690544277297 0.074473963480548 1.0 0.4797544742885926 5 P04083 1 +Tubulin deacetylation 0.8495333144919875 1.7814664520807586 0.07483628071085 1.0 0.4804701727522755 4 P61964 1 +Response to axon injury 0.6206671860225357 1.781099076947858 0.0748962665189449 1.0 0.4804701727522755 11 Q99707,P11047,P04179,P00374,Q96G23 5 +Leukocyte chemotaxis 0.515767183278119 1.7805901078787405 0.0749794369747602 1.0 0.4804701727522755 22 P14174,P04083 2 +Negative regulation of glial cell proliferation 0.9623875715453803 1.778746100478214 0.0752813974376753 1.0 0.4804701727522755 2 Q9UPY3 1 +Negative regulation of schwann cell proliferation 0.9623875715453803 1.778746100478214 0.0752813974376753 1.0 0.4804701727522755 2 Q9UPY3 1 +Schwann cell proliferation 0.9623875715453803 1.778746100478214 0.0752813974376753 1.0 0.4804701727522755 2 Q9UPY3 1 +Negative regulation of alpha beta t cell activation 0.7804801364026146 1.7732486108124437 0.0761875202932329 1.0 0.483786661318483 5 P04083 1 +Pigmentation 0.6191324339043258 1.77323028095515 0.0761905563235871 1.0 0.483786661318483 11 Q96AX1,Q9BXS5,P04179,O43747 4 +Negative regulation of response to external stimulus 0.4512976140342745 1.7709878037703604 0.0765627298769178 1.0 0.4838698784573571 37 P14174,Q9UMX5,P80303,P19474,P28070,Q96G23 6 +Regulation of hemopoiesis 0.4411557311496865 1.766881842632581 0.0772480184823969 1.0 0.4875103605443952 39 Q96T37,P56537,P04083,Q9BXW9,P40763,Q99873,Q9H3U1,Q6PD62,P61586,O15347 10 +Oxidative rna demethylation 0.957890433360589 1.7606598695195967 0.0782959888529253 1.0 0.4902958101356942 2 Q9C0B1 1 +Oxidative demethylation 0.957890433360589 1.7606598695195967 0.0782959888529253 1.0 0.4902958101356942 2 Q9C0B1 1 +Positive regulation of developmental process 0.3441947196035981 1.7601939923824652 0.0783749202530097 1.0 0.4902958101356942 149 Q8WUJ1,P04792,Q9UQB8,Q9Y624,P80723,P78344,P04083,P04179,O14786,O15144,Q99873,P61586,Q04637,P43246,O75340,O60271,Q86X55,Q9UPY3,Q9Y4C8,O43324,Q15014,P15311,P16989,P41440,Q9H4M9,Q96A49,Q9H3U1,P50570,Q92766,P17655,Q9H2J4,Q99829,P27695,P40763,P17931,Q07812,O14744,Q15418 38 +Apoptotic dna fragmentation 0.7771503886260649 1.7595511889034714 0.0784839337785341 1.0 0.4902958101356942 5 O95831,Q9UPY3 2 +Regulation of response to food 0.9566639411283728 1.755724609032906 0.0791354427253767 1.0 0.4911904541804783 2 Q9UMX5 1 +Negative regulation of response to food 0.9566639411283728 1.755724609032906 0.0791354427253767 1.0 0.4911904541804783 2 Q9UMX5 1 +Regulation of appetite 0.9566639411283728 1.755724609032906 0.0791354427253767 1.0 0.4911904541804783 2 Q9UMX5 1 +Extracellular matrix assembly 0.8428938276710504 1.7554884873186267 0.0791757881859354 1.0 0.4911904541804783 4 Q96AY3,O60568 2 +Glutathione metabolic process 0.5462175530047371 1.754421502322997 0.079358309584415 1.0 0.4914744369661508 18 P11413,O75874,Q9UJ14,P04179,P28161 5 +Negative regulation of amyloid fibril formation 0.8424713584288027 1.7538337912704671 0.0794589910972649 1.0 0.4914744369661508 4 P61758,O15212,Q99471 3 +Regulation of skeletal muscle tissue development 0.8422137884842282 1.752824860392767 0.0796320744671343 1.0 0.4920549079013975 4 P16989 1 +Regulation of vasculature development 0.484256379461932 1.740628852151439 0.081748656858827 1.0 0.4944071378949205 27 O75340,Q9H2J4,P04792,P40763 4 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.6299031792122747 1.7326144158942154 0.0831642252496986 1.0 0.4944071378949205 10 P04792 1 +Protein hydroxylation 0.5944825409595682 1.730338188279704 0.0835698704079417 1.0 0.4944071378949205 13 O75718,Q96AY3,O60568,O15460 4 +Mitochondrion distribution 0.8358570055325567 1.727900838233569 0.0840060040329553 1.0 0.4944071378949205 4 Q9BUK6,O75153 2 +Establishment of tissue polarity 0.7693569172481554 1.7274316081345589 0.0840901780797218 1.0 0.4944071378949205 5 P61586 1 +Regulation of response to extracellular stimulus 0.8349175786290443 1.7242136510440955 0.0846692806541773 1.0 0.4944071378949205 4 Q9UMX5 1 +Muscle cell migration 0.6282046042592209 1.724172947109853 0.0846766263323268 1.0 0.4944071378949205 10 P04083 1 +Demethylation 0.5932359129257714 1.7236291997332864 0.0847748037252142 1.0 0.4944071378949205 13 Q6P6C2,Q9C0B1,Q8NB78 3 +Cd4 positive alpha beta t cell differentiation 0.7682493333020556 1.722860167230178 0.0849138151067943 1.0 0.4944071378949205 5 P04083 1 +I kappab kinase nf kappab signaling 0.4409010605149207 1.722390729547744 0.0849987618921477 1.0 0.4944071378949205 38 Q92734,P04792,P19474,Q13325,P61586,Q99584 6 +Positive regulation of phosphatase activity 0.7268263169902861 1.7199879520678638 0.0854346316056595 1.0 0.4944071378949205 6 Q15257 1 +Monocarboxylic acid biosynthetic process 0.4580406146896811 1.7196272449531642 0.0855002204668389 1.0 0.4944071378949205 34 Q14353,P02656,P14174,P04083 4 +Regulation of wound healing 0.626210669326057 1.7142560011918704 0.0864817199567025 1.0 0.4944071378949205 10 P04083 1 +Regulation of cell migration involved in sprouting angiogenesis 0.8319091167587881 1.7123991134621797 0.086823142338714 1.0 0.4944071378949205 4 P04083 1 +Modification of postsynaptic actin cytoskeleton 0.7655032851033929 1.7115190528406028 0.0869853370527096 1.0 0.4946693618107387 5 P61586 1 +Organic acid transport 0.4605899525887371 1.7088597546778472 0.0874769308865208 1.0 0.4964824577233282 33 P14174,O43772,P41440,P04083,O95563,Q15042,O14745 7 +Protein localization to cell junction 0.572159975706948 1.7080667527745963 0.0876239571118788 1.0 0.4964824577233282 15 Q9UDY2,P04792 2 +Regulation of histone deacetylation 0.7233837419482878 1.7052249766564636 0.0881524734751448 1.0 0.4985672680151636 6 Q13363,P61964 2 +Positive regulation of blood vessel endothelial cell migration 0.6702757450103308 1.6991531611257025 0.0892903290408746 1.0 0.5013498583578947 8 P04792 1 +Dna catabolic process 0.6989564848719587 1.6968723783042887 0.0897207911819442 1.0 0.5019678343481652 7 O95831,O00273,P27695,Q9UPY3 4 +Protein homooligomerization 0.4421238296612708 1.6933387935044557 0.0903909979722288 1.0 0.5042275496771241 37 Q99720,O43633,P14174,Q9NWX6,P35637,P34896,P04179,Q9H223,Q99873,Q9NXV2 10 +Exocytosis 0.4145406409530534 1.6920285020793822 0.0906405393310754 1.0 0.5042275496771241 48 O43633,Q8TAG9,P27695,Q99816,Q8TBQ9,P20339,O00471,P04083,P0DP25,Q15042,Q5JRA6,Q99584 12 +Positive regulation of tumor necrosis factor superfamily cytokine production 0.5953995163975507 1.6908502400825327 0.0908654089875211 1.0 0.5042275496771241 12 Q02952,P14174,P04792,P40763 4 +Peptidyl arginine n methylation 0.8256955810147263 1.6879669771323116 0.0914175682186106 1.0 0.504624976566731 4 O60678,Q99873,O14744 3 +Peptidyl arginine methylation 0.8256955810147263 1.6879669771323116 0.0914175682186106 1.0 0.504624976566731 4 O60678,Q99873,O14744 3 +Taxis 0.4092122690475607 1.6861341355224206 0.0917699664762392 1.0 0.5056712438486652 51 Q8TEY7,Q8WX93,P14174,Q9NUQ9,P04792,P11047,P04083,P35613,P17931,P61586,O75592,O95372 12 +Regulation of modification of postsynaptic structure 0.8249044094408159 1.684853085866922 0.0920169198334535 1.0 0.5061338105985352 4 P61586 1 +Regulation of modification of synaptic structure 0.8249044094408159 1.684853085866922 0.0920169198334535 1.0 0.5061338105985352 4 P61586 1 +Positive regulation of nitric oxide synthase biosynthetic process 0.9539366236877704 1.6783271274619844 0.0932832550487376 1.0 0.5074883578821188 3 P43490 1 +Nitric oxide synthase biosynthetic process 0.9539366236877704 1.6783271274619844 0.0932832550487376 1.0 0.5074883578821188 3 P43490 1 +Regulation of metal ion transport 0.4442533141181338 1.6742866830033394 0.0940742704496067 1.0 0.5082437650565602 36 P28161,P11413,P27695,Q9Y376,P30626,P17931,P0DP25,Q07812,Q00535,P50570,P54652,P61586,O14745,P33176,P35609 15 +In utero embryonic development 0.368790233087643 1.6725438271426047 0.0944171330939926 1.0 0.5082437650565602 73 O43772,Q9UNS2,Q7Z6E9,P67809,Q08J23,Q99873,Q12824,Q9ULT8,Q96AY3,P43246,P35579,P31350,P62993,Q6DKJ4,Q96EK5,Q9BRT9,O60568,Q6PD62,P61201,P49321,P16989,P20290,O95983,Q5TBB1,Q9NVX2,Q13263,P17655,O75312 28 +Regulation of oxidative stress induced cell death 0.5917373493300968 1.671509557275458 0.0946210725390956 1.0 0.5082437650565602 12 P04792 1 +Positive regulation of protein serine threonine kinase activity 0.5075006360158265 1.6706142861726547 0.0947978888345235 1.0 0.5082437650565602 20 Q9Y376,P61586,P14174,P0DP25 4 +Negative regulation of tor signaling 0.93499591169256 1.6683633374410056 0.0952436216228338 1.0 0.5082437650565602 2 Q96B36 1 +Regulation of myeloid cell apoptotic process 0.9511509949022344 1.6680209533662416 0.0953115673510223 1.0 0.5082437650565602 3 P04083 1 +Myeloid cell apoptotic process 0.9511509949022344 1.6680209533662416 0.0953115673510223 1.0 0.5082437650565602 3 P04083 1 +Regulation of neuron differentiation 0.5198295568050042 1.6678186281760317 0.0953517367984195 1.0 0.5082437650565602 19 Q8WUJ1 1 +Dendrite self avoidance 0.9341782502044164 1.6650608608127369 0.0959006142549609 1.0 0.5082437650565602 2 P35613 1 +Cellular protein catabolic process 0.345126578043256 1.6650160065787485 0.0959095624348032 1.0 0.5082437650565602 186 O43633,Q92530,Q9UNS2,Q7Z6E9,Q16763,P48506,P48556,Q15386,Q9UJX4,Q13200,Q9UHG3,Q9BUN8,Q9ULT8,P25789,Q9NXV2,Q8N511,Q8TEY7,P25787,P49721,P35241,Q9Y4X5,Q9Y5X3,P28072,P28074,Q9UBV2,Q9NRR5,P28070,P54727,Q5VTR2,A0AVT1,Q14258,P15311,Q99436,Q9UNZ2,Q99816,P63208,P51665,Q9Y5K6,P20618,Q93034,Q9H2J4,Q15008,Q9UN37,O43242,Q86UV5,Q96T88,Q04323,Q5VYK3,Q9UJX2,P60900,P46777,P17655,Q5TDH0,Q06323,Q96J02 55 +Regulation of chemotaxis 0.5193829285466194 1.6649770366477932 0.0959173372701966 1.0 0.5082437650565602 19 P14174,O75592,P04792 3 +Regulation of calcium ion transmembrane transporter activity 0.5904410336471314 1.664656470597212 0.0959813120912274 1.0 0.5082437650565602 12 P27695,P0DP25,Q00535,P54652,P28161 5 +Interstrand cross link repair 0.8196471403507004 1.6641450663559405 0.0960834428625445 1.0 0.5082437650565602 4 Q9H1E3 1 +Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.7537170108751277 1.6627302602159677 0.0963664420883727 1.0 0.5084414913188443 5 P04792 1 +Mismatch repair 0.691248393725219 1.6626969033500474 0.0963731223960486 1.0 0.5084414913188443 7 Q9UQ84,P15927 2 +Regulation of actin filament length 0.4428233101330308 1.6623215380572876 0.0964483215416422 1.0 0.5084414913188443 36 Q9NYL9,Q9NUQ9,Q9UQB8,Q9Y281,P62993,Q14247,P35241,Q14019,O15143,O15144,P61586,P35609,Q92747 13 +Protein polymerization 0.3852351251865897 1.6578763706606638 0.0973424224401511 1.0 0.5106464856593246 61 Q9NYL9,O43633,Q9UQB8,Q16763,Q14203,Q14019,P16949,O15143,O15144,P61586,P62993,Q14247,P35241,Q13526,Q02790,Q9BTW9,Q9NUQ9,Q96S59,Q15691,Q92747 20 +Deoxyribonucleoside monophosphate biosynthetic process 0.7524307766352933 1.657395268032526 0.097439587484513 1.0 0.5106464856593246 5 P34896 1 +Negative regulation of transporter activity 0.5966386369618542 1.6572978442401023 0.0974592729446808 1.0 0.5106464856593246 11 Q9Y376,P30626,P0DP25,O14745,P28161 5 +Copii coated vesicle budding 0.5535438303820105 1.6572159908322777 0.0974758147087797 1.0 0.5106464856593246 16 Q15436,Q92734,Q5JRA6 3 +Regulation of leukocyte differentiation 0.5012536492356788 1.6548262902766355 0.097959739449148 1.0 0.5116316080565259 21 P61586,Q9BXW9,P04083 3 +Positive regulation of transmembrane transport 0.4775719526193839 1.651301681325636 0.0986769891564818 1.0 0.5140806230383826 26 P11413,P27695,P30626,P0DP25,Q00535,P50570,P54652,P28161,O14745,P35609,Q06124 11 +Positive regulation of locomotion 0.3961164222169364 1.6501830180869153 0.0989055090571864 1.0 0.514408049619035 56 O75340,Q13630,Q15555,P04792,O60271,P31949,O95684,P04179,P04083,P40763,P17931,Q02952,P61586,Q92766,Q5JRA6 15 +Pyrimidine nucleobase biosynthetic process 0.687950390281852 1.6480465232069046 0.0993431247316682 1.0 0.5152976256590772 7 Q05682,Q9NRF8,P11172,P17812 4 +Actin filament based process 0.3285914363578971 1.6474456291514097 0.0994664831077905 1.0 0.5152976256590772 126 Q9NYL9,Q9UQB8,Q9Y624,Q9Y2I1,Q14019,P04083,P16949,O15143,O14786,O15144,P61586,P11233,P35579,Q8WX93,Q99439,Q14247,Q01518,P62993,P30626,P35241,Q96HC4,Q9UM22,Q9NQW6,O00151,P35609,P15311,Q9Y281,Q05682,P52565,O14745,Q9Y490,O75592,Q9Y5K6,Q9NUQ9,Q9H2J4,Q9UN37,Q15942,Q00535,Q92747 39 +Cellular metabolic compound salvage 0.6876416504914835 1.646674199390568 0.0996250301165462 1.0 0.5152976256590772 7 Q9BZX2,Q13126,P55263 3 +Cellular response to mechanical stimulus 0.7088899304565575 1.6428794904841946 0.1004078692438621 1.0 0.5152976256590772 6 Q9Y624,Q99439 2 +Positive regulation of neuron apoptotic process 0.6295040778366882 1.642656409626647 0.1004540424500706 1.0 0.5152976256590772 9 O95831,Q07812,Q00535,P61081,P78362,P61586 6 +Regulation of protein deubiquitination 0.686720178512142 1.6425774809554086 0.1004703831346129 1.0 0.5152976256590772 7 P19474,Q04323 2 +Regulation of multicellular organismal development 0.3308016754469969 1.642496330831656 0.1004871859377041 1.0 0.5152976256590772 132 P04792,Q9UQB8,Q96T37,P80723,P04083,Q99873,P61586,P23381,Q06124,O75340,P56537,Q6PD62,Q9UPY3,Q9H9B1,Q13247,Q9H3U1,Q96G23,Q9H2J4,P11413,Q9Y5A9,P27695,Q9BXW9,Q8N0X7,P40763,P17931,Q00535,O14744,O75312,O15347 29 +Negative regulation of microtubule polymerization 0.8138297872340358 1.641198348044054 0.1007562485359725 1.0 0.5162510754194632 4 Q15691,P16949,Q02790 3 +Regulation of protein kinase a signaling 0.9434501890241818 1.639503242791791 0.1011084958752985 1.0 0.5172024377146657 3 P14174 1 +Vasodilation 0.9272281275551923 1.6369748007409182 0.1016357349783052 1.0 0.5188552320150779 2 P04179 1 +Response to electrical stimulus 0.7473622901290422 1.636352621972996 0.1017658087913631 1.0 0.5188552320150779 5 Q02952 1 +Response to acid chemical 0.5268355470886723 1.6351280601108014 0.1020222049943218 1.0 0.5189907255016105 18 Q9UQB8,Q99729,P48506,O95831,Q15149,P17655,P61586,O00410,Q6IAA8 9 +Viral protein processing 0.706992585169602 1.6346959284023752 0.102112806467058 1.0 0.5189907255016105 6 P61009 1 +Leukocyte migration 0.435170358967334 1.6342138144285083 0.1022139628683345 1.0 0.5189907255016105 37 P61586,P14174,Q5JRA6,P04083 4 +Cellular response to chemical stress 0.3827907849703333 1.6314254511166677 0.1028005781964367 1.0 0.5190502302943345 61 Q99720,P16989,P04792,P04179,P04083,O95831,P35237 7 +Modification dependent macromolecule catabolic process 0.3351465416276516 1.6313470230367624 0.1028171165169877 1.0 0.5190502302943345 146 O43633,Q92530,Q9UNS2,Q7Z6E9,Q16763,P48506,P48556,Q15386,Q9UJX4,Q13200,Q9UHG3,Q9BUN8,Q9ULT8,Q9NXV2,Q8TEY7,P30260,P25787,Q9Y4X5,Q99460,Q9UBV2,Q9NRR5,P54727,Q5VTR2,A0AVT1,Q14258,O00231,Q9UNZ2,Q99816,P63208,P46379,P45974,P51665,O15372,Q9Y5K6,Q93034,Q5T4S7,Q9H2J4,Q9UN37,O43242,Q86UV5,Q96T88,Q04323,Q5VYK3,Q9UJX2,P46777,Q15008,Q96J02,Q14139 48 +Histone deacetylation 0.4892284273552358 1.63039831122596 0.1030173413614075 1.0 0.5190502302943345 23 Q13363,Q9H4L7,Q15014 3 +Regulation of leukocyte apoptotic process 0.6552733751705772 1.6297523700535397 0.1031538440489456 1.0 0.5190502302943345 8 P04083 1 +Dna replication checkpoint signaling 0.8100585308273291 1.6263048276376706 0.1038848253053261 1.0 0.5190502302943345 4 Q92547 1 +T cell differentiation involved in immune response 0.8097584741379841 1.6251192539812378 0.1041371510671775 1.0 0.5190502302943345 4 P04083 1 +Regulation of cell projection organization 0.3613474844572141 1.6233719295062894 0.104509921590054 1.0 0.519442897460481 81 Q9NT62,Q9UQB8,Q15428,O60828,P78344,O14786,O15144,P61586,P08670,P11233,Q15555,Q04917,P35241,Q86X55,Q8NCA5,Q9NQW6,Q9NR77,Q8TC07,Q02790,P15311,P51116,Q9H4M9,P50570,Q9P258,Q92766,Q96G23,P27695,P20339,Q8N0X7,Q00535 30 +Cd4 positive alpha beta t cell activation 0.6821072175180642 1.6220500905792152 0.1047926233323819 1.0 0.5197781077428848 7 P04083 1 +Dendritic spine morphogenesis 0.6069127972198374 1.6178686274755767 0.1056909126148815 1.0 0.5217333603643992 10 Q96HC4,O60678,Q00535,Q9UQB8 4 +Protein demethylation 0.7425415087319953 1.616309754972369 0.1060273587859788 1.0 0.5219387215305619 5 Q8NB78 1 +Histone lysine demethylation 0.7425415087319953 1.616309754972369 0.1060273587859788 1.0 0.5219387215305619 5 Q8NB78 1 +Regulation of actin filament based process 0.3677791400330971 1.6157297564768578 0.1061527544755394 1.0 0.5219387215305619 66 Q9NYL9,Q9UQB8,Q9Y624,Q14019,P16949,O15143,O14786,O15144,P61586,P35579,Q99439,P62993,Q14247,P30626,P35241,P59998,P35609,P15311,Q9Y281,P52565,P60953,O75592,Q9Y5K6,Q9NUQ9,Q00535,Q92747 26 +Regulation of stem cell differentiation 0.5233627262805283 1.6136438434979608 0.1066047011182047 1.0 0.5231991186022645 18 Q9Y5A9,Q8WX92,P40763,Q9NYV4,O15047,Q96J02 6 +Positive regulation of leukocyte proliferation 0.6060339025669096 1.6134619327409374 0.1066441872062695 1.0 0.5231991186022645 10 P04083 1 +Regulation of dendrite development 0.5804615810599391 1.6117811401430513 0.1070095736236953 1.0 0.5236638709244665 12 P61586,O60828,Q86X55,Q9UQB8 4 +Negative regulation of mrna processing 0.4983853208517944 1.6106038515822605 0.1072660938082457 1.0 0.5244046234851594 20 P61978,P38159,Q13247,Q12872,P98175,Q8WXF0,O00422,Q5VTR2,Q6PD62,O00267 10 +Tumor necrosis factor superfamily cytokine production 0.5455021974305134 1.6103116592604094 0.1073298351770752 1.0 0.5244046234851594 16 Q9UPY3,P14174,P04792 3 +Negative regulation of cell size 0.8054911551723758 1.6082492473225574 0.1077806012686217 1.0 0.5257796809726167 4 P61586 1 +Negative regulation of lipid biosynthetic process 0.6777284062512143 1.6025360993527784 0.1090371114169148 1.0 0.529000360858626 7 P02656 1 +Histone h4 acetylation 0.5214127096008425 1.6015666680783112 0.1092514665146875 1.0 0.5295854414067306 18 Q13363,P61964,Q15014 3 +Cellular response to stress 0.2677388021945161 1.6000652678541991 0.1095841050253862 1.0 0.5295854414067306 378 Q9H773,P04792,Q9UQ84,P51530,P04179,P04083,Q9NXR7,Q99873,P61586,Q9BUN8,Q92547,Q04637,P43246,Q06124,O75340,Q8TEY7,P14174,Q15645,Q9H4L7,Q9Y2K7,Q9Y3C8,Q9Y376,Q99707,P62993,P57081,Q9BRT9,Q9NRR5,P54727,P54652,A0AVT1,O15047,Q15014,Q96A26,Q99720,Q9H1E3,P55145,P16989,P41440,Q9NW82,O95831,Q9C0B1,P46063,P25685,Q6Y7W6,P35237,Q96G23,Q9NWX6,P17096,P35637,P11047,Q04323,Q9BXW9,P15927,P55786,P28161,Q969Z3,Q96J02 57 +Regulation of protein polymerization 0.4048717711812329 1.5992674938042273 0.1097611790451082 1.0 0.5297762669957186 48 Q9NYL9,Q9NUQ9,Q9UQB8,Q92747,P62993,Q14247,Q14203,P35241,Q14019,Q9BTW9,P16949,Q15691,O15143,O15144,P61586,Q02790 16 +Lung morphogenesis 0.6485937064024035 1.5987348883504306 0.1098795220435564 1.0 0.5297762669957186 8 Q13247 1 +Protein neddylation 0.7377720978318064 1.596453888348598 0.1103874930094157 1.0 0.531400257045327 5 Q8TBC4,P61081 2 +Negative regulation of oxidative stress induced cell death 0.6196745834805403 1.595024888823665 0.1107066702387213 1.0 0.5314208169556622 9 P04792 1 +Negative regulation of intrinsic apoptotic signaling pathway 0.4619289558038741 1.5945527689825691 0.1108122815849954 1.0 0.5314208169556622 28 P16989,P14174,P04792 3 +Modification of synaptic structure 0.6465242233821473 1.589111164558493 0.1120352976385201 1.0 0.5334576754099922 8 P61586 1 +Pyridine containing compound metabolic process 0.6963746389562525 1.5888094259944745 0.1121034245426795 1.0 0.5334576754099922 6 P43490 1 +T cell differentiation 0.4948874032459451 1.5875105907360034 0.1123970502450637 1.0 0.5344453920534807 20 P61586,Q9BXW9,P04083 3 +Gtp metabolic process 0.6007464206300883 1.5869217466450078 0.1125303689492269 1.0 0.5346699243876814 10 P61586,O00178 2 +Protein autoubiquitination 0.6174048903237206 1.5840033310809023 0.1131929610620559 1.0 0.5349506117892286 9 P19474 1 +Regulation of release of sequestered calcium ion into cytosol 0.6454194940348864 1.583971201494073 0.1132002727790657 1.0 0.5349506117892286 8 P28161,P30626,P0DP25,P27695 4 +Regulation of calcium ion transport into cytosol 0.6454194940348864 1.583971201494073 0.1132002727790657 1.0 0.5349506117892286 8 P28161,P30626,P0DP25,P27695 4 +Serine family amino acid biosynthetic process 0.6732359345041135 1.5824875330754389 0.1135383161257905 1.0 0.5349506117892286 7 P34896,P49903 2 +Filopodium assembly 0.5994446226584884 1.580379905776099 0.1140198905139027 1.0 0.5349506117892286 10 P15311,P51116,P20339,O14786,P11233 5 +Regulation of cell cell adhesion 0.4286602657843228 1.5786654659763109 0.1144128099256689 1.0 0.5349506117892286 37 Q9NUQ9,Q9Y5A9,Q9Y624,P41440,P04083,P17931,P61586,Q5JRA6,Q96J02,Q06124 10 +Protein localization to extracellular region 0.4037533961831613 1.5759476493956344 0.1150378684136121 1.0 0.5349506117892286 47 P15311,O43768,Q8TBQ9,P30626,P20645,P04083,O95563,O75592,Q9UBV2,Q9Y5K6,Q5JRA6,Q06124 12 +Leukocyte cell cell adhesion 0.4473293772646862 1.574900611944152 0.1152793874027111 1.0 0.5349506117892286 32 Q13630,Q9NUQ9,P04083,P17931,P61586,Q5JRA6,Q96J02,Q06124 8 +Deoxyribonucleoside monophosphate metabolic process 0.6712757372382587 1.5737310792905002 0.1155496335086763 1.0 0.5349506117892286 7 P34896 1 +Protein localization to synapse 0.6712521191893734 1.5736255428034656 0.1155740445044317 1.0 0.5349506117892286 7 P04792 1 +Regulation of rho protein signal transduction 0.5732802407934062 1.573607797764737 0.1155781493983623 1.0 0.5349506117892286 12 P02656 1 +Retinoic acid metabolic process 0.9108748977923156 1.5707973866211091 0.1162297193118426 1.0 0.5349506117892286 2 Q9HB40 1 +Regulation of lipid localization 0.538631714564461 1.5701211762351734 0.1163869229066403 1.0 0.5349506117892286 16 O60664,P02656,P14174,Q06124 4 +Toxin metabolic process 0.9104660670482424 1.569141535909479 0.1166149633277031 1.0 0.5349506117892286 2 P40616 1 +Negative regulation of leukocyte migration 0.731002657757589 1.56822793370733 0.116827947541398 1.0 0.5349506117892286 5 Q5JRA6 1 +Protein deneddylation 0.6414351757223771 1.565418439262333 0.1174848276444873 1.0 0.5360622921912316 8 Q99627,Q9UNS2,Q9UBW8,Q92905,P61201 5 +Cop9 signalosome assembly 0.908830744071956 1.5625175421459387 0.1181661166056313 1.0 0.5380690932647967 2 Q9UBW8 1 +Secretion 0.323863206888229 1.5552340562662064 0.1198903361446632 1.0 0.5410776916569024 110 O43633,Q9UNS2,P20645,P04083,P11172,P55327,Q5JRA6,P11233,Q06124,P35579,P14174,O43768,Q8TAG9,P07741,Q8TBQ9,P30626,Q9Y5X3,O95563,Q9UBV2,P61201,P15311,P55011,Q99816,Q96KC8,Q6ZWJ1,Q15042,O14745,O75592,Q9Y5K6,O43747,P27695,P20339,Q9UN37,O00471,P17858,P0DP25,Q00535,Q99584 38 +Neuron death 0.3846481662303707 1.5531444716201726 0.1203886237156059 1.0 0.5425350894585728 57 P04179,P61586,Q04637,P43246,Q01105,Q15392,P61081,Q96A26,Q99720,P51858,O95831,Q9NQ88,Q96B36,P11413,Q9UMX5,Q9NR28,Q00535,P17655,O75312 19 +Response to bacterium 0.3999206311269474 1.5515939363844806 0.1207594149447255 1.0 0.5427946801828 48 Q9NUQ9,P14174,Q9UQB8,P04179,P81605,Q02952,Q6PD62,P61586 8 +Folic acid transport 0.9059689288634524 1.5509233848301782 0.1209200455813332 1.0 0.5427946801828 2 P41440 1 +Folate transmembrane transport 0.9059689288634524 1.5509233848301782 0.1209200455813332 1.0 0.5427946801828 2 P41440 1 +Response to x ray 0.5760861987907968 1.550459790521867 0.1210311973212572 1.0 0.5427946801828 11 P04083 1 +Negative regulation of gliogenesis 0.918501544837854 1.5468760254034015 0.1218931432033589 1.0 0.5427946801828 3 Q9UPY3 1 +Tissue migration 0.4064911229211722 1.5459827443900644 0.1221087352584964 1.0 0.5427946801828 41 O75340,Q13630,Q15555,P04792,P04083,Q9NQW6,P61586,Q5JRA6,Q06124 9 +Positive regulation of actin filament polymerization 0.5920763760448285 1.543298703977681 0.122758317944202 1.0 0.5432836883566533 10 P62993,P61586,O15144,Q9UQB8 4 +Regulation of gliogenesis 0.6089339201330136 1.542795959743781 0.1228802900877619 1.0 0.5432836883566533 9 Q9UPY3,Q96G23 2 +Regulation of endothelial cell migration 0.4803487999861915 1.54045686809784 0.1234490286778209 1.0 0.5433157109066392 22 O75340,P61586,P04792,P04083 4 +Response to oxygen levels 0.395888800484077 1.5397959904850538 0.1236100895902168 1.0 0.5433192136177921 50 Q96A26,Q8N511,Q6P6C2,P04179,Q15904,Q13526,O95831,P55786,P61586 9 +Prostanoid metabolic process 0.5740314428540954 1.539735636129952 0.1236248065768019 1.0 0.5433192136177921 11 Q8N4Q0,P04083 2 +Nucleotide salvage 0.7232284352946067 1.5357524860999117 0.1245990969667125 1.0 0.5445182210860556 5 Q9BZX2,P55263 2 +Interleukin 1 production 0.5904911317476736 1.535309224074982 0.1247078894482585 1.0 0.5446104032866985 10 Q99584,P04792,P04083 3 +Negative regulation of stress activated protein kinase signaling cascade 0.6622989466052788 1.5335659178646213 0.1251364783546882 1.0 0.5447470439368992 7 P15311,P31689,Q96J02,P51452 4 +Regulation of mitochondrial gene expression 0.6622118620941164 1.5331757686615417 0.1252325529402167 1.0 0.5447470439368992 7 Q567V2 1 +Negative regulation of hydrolase activity 0.3919749508783512 1.5321863987099824 0.1254764439338827 1.0 0.5447470439368992 52 P02656,Q15392,P04083,Q15257,P35237 5 +Interleukin 6 mediated signaling pathway 0.9010629599345894 1.5310418851304768 0.1257590411969231 1.0 0.5447470439368992 2 Q6PD62 1 +Negative regulation of phosphatase activity 0.721833304537193 1.529918108204916 0.1260370005118631 1.0 0.5450485885645336 5 Q15257 1 +Positive regulation of cytokine production 0.3898699144548639 1.5280793694760595 0.1264928330067447 1.0 0.5462590354463733 53 Q9NUQ9,P14174,O60684,P04792,P41440,O60828,P04083,P40763,Q02952,Q99584 10 +Negative regulation of cell cell adhesion 0.5310155133945176 1.5254516050625329 0.1271464956187489 1.0 0.5485148267589582 16 Q9Y5A9,P04083,P17931,Q5JRA6,Q96J02 5 +Response to growth factor 0.3551544767246578 1.5243208749140356 0.1274285750063564 1.0 0.5491543725117788 77 P04792,Q9UQB8,P48506,P04083,Q9UQ13,Q06124,O75340,O00400,Q13526,Q9Y2U8,Q9H4M9,O14737,Q9H223,Q96A49,Q96B36,P27695,Q15942,P49354,P40763,Q8N0X7,O75312 21 +Mitochondrion localization 0.570383813688099 1.5206803068207129 0.1283400830043872 1.0 0.5515514985863287 11 Q9BUK6,O75153,Q8IWA4 3 +N terminal peptidyl methionine acetylation 0.8982011447260861 1.5194413781008222 0.1286514332899218 1.0 0.5525071927596226 2 Q5VZE5 1 +Apical junction assembly 0.5291074722487739 1.5142427801285574 0.1299642751339562 1.0 0.5546618083705641 16 Q9Y624,P17612,Q8WUM4,Q9BTW9,Q13177,P18206,P61586 7 +Positive regulation of cytokine production involved in inflammatory response 0.8961569910057234 1.511154142805938 0.1307491828239204 1.0 0.5557364393095878 2 P40763 1 +Regulation of calcium ion transport 0.4758058892317029 1.5093834534955983 0.1312008190670461 1.0 0.5559390514890808 22 P28161,P11413,P27695,P30626,P17931,P0DP25,Q00535,P54652,P61586 9 +Cell death in response to oxidative stress 0.5281431715298928 1.50857535599152 0.1314073359124206 1.0 0.5559390514890808 16 Q99720,P04792 2 +Purine ribonucleoside salvage 0.7167217142511582 1.5085256273695662 0.131420052751364 1.0 0.5559390514890808 5 Q13126,P55263 2 +Nucleoside salvage 0.7167217142511582 1.5085256273695662 0.131420052751364 1.0 0.5559390514890808 5 Q13126,P55263 2 +Purine nucleoside biosynthetic process 0.7167217142511582 1.5085256273695662 0.131420052751364 1.0 0.5559390514890808 5 Q13126,P55263 2 +Regulation of hematopoietic stem cell differentiation 0.6558440530062192 1.5046221927855383 0.1324212372607154 1.0 0.5567609230799205 7 O15047,Q96J02 2 +Vascular process in circulatory system 0.4621028974107842 1.5033923758750236 0.1327378914697541 1.0 0.5571588674266745 25 P41440,Q9UDY2,P04179,O60568,Q02952,P61586,Q9HB40 7 +Regulation of histone h2b ubiquitination 0.7787520692273162 1.5021869484260373 0.1330488345431499 1.0 0.5571588674266745 4 Q9NW82,Q6PD62 2 +Vascular endothelial growth factor receptor signaling pathway 0.6544101589628322 1.4981859108204032 0.1340849551454721 1.0 0.5596641404875686 7 P04792 1 +Ameboidal type cell migration 0.3832678046518926 1.4977324669096002 0.1342027729466619 1.0 0.5597039758218741 55 O75340,Q13630,Q15555,P04792,Q01518,P04083,Q9NQW6,Q02952,P61586,Q9P258,Q5JRA6,Q06124 12 +Protein localization to plasma membrane 0.3812605095341125 1.4968372915917814 0.1344356003146249 1.0 0.5599376423837115 56 Q9Y624,P41440,Q9H4M9,P35241,Q8IWJ2,P35613,Q15904,O00471,Q9H223,P17931,Q00535,O14745,Q9ULT8,Q15436,P35609 15 +Cellular response to hydrogen peroxide 0.5434376557471032 1.4963842101152507 0.1345535618685729 1.0 0.5599376423837115 14 Q99720,P04083 2 +Viral transcription 0.5432257946342147 1.4951983819566137 0.134862675700363 1.0 0.5599376423837115 14 Q13148,O14646,Q9H1E3,P19474 4 +Receptor signaling pathway via stat 0.5815979728439136 1.4904167508118884 0.1361146908018702 1.0 0.5635755133486584 10 Q6IA86,P40763,Q00535,Q6PD62,P30153 5 +Dendrite morphogenesis 0.4918531794867047 1.4887896724361696 0.1365427627119837 1.0 0.5642356516938632 19 Q04917,Q9UQB8,O60828,Q96HC4,O14786,Q00535,O60678 7 +Schwann cell differentiation 0.7118297175603773 1.4880295502795249 0.1367431007728283 1.0 0.5642356516938632 5 Q9UPY3,P11047,Q00535,Q15149 4 +Dna geometric change 0.3999211531357091 1.4857014861551705 0.1373580973728967 1.0 0.5646480000543255 41 P17096,Q9H4L7,P51530,P04083,Q9BRT9,P46063,O15347 7 +Protein modification by small protein removal 0.4177369230406617 1.4850877942691427 0.1375205689433829 1.0 0.5646480000543255 37 Q9UNS2,Q15018,Q92905,Q9NXR7,P19474,Q9H4L4,Q8TEY7,Q9Y5K5,P61201,Q15020,P06493,Q9H8M7,Q9UBW8,P45974,Q99627,Q96FW1,Q86UV5,Q04323,Q96J02 19 +Prostanoid biosynthetic process 0.6720345061328739 1.4830966681455906 0.1380487291289927 1.0 0.5646480000543255 6 P04083 1 +Vesicle cargo loading 0.5966160373838164 1.48268495357901 0.1381581341064839 1.0 0.5646480000543255 9 Q5JRA6 1 +Maintenance of blood brain barrier 0.6508964078793175 1.4824039418094224 0.1382328457675092 1.0 0.5646480000543255 7 Q9UDY2,Q9Y624,P11047,P55011 4 +Purine containing compound salvage 0.6718323771517836 1.482216037570636 0.1382828206066331 1.0 0.5646480000543255 6 P55263,Q13126,P07741,P00491 4 +Regulation of anatomical structure size 0.3525883592022026 1.482185511057582 0.1382909407244714 1.0 0.5646480000543255 74 Q9NYL9,Q9UQB8,P48506,Q14019,P04179,P78344,O15143,O14786,O15144,P61586,P62993,Q14247,P35241,O60568,P35609,P15311,Q9Y281,P55011,P50570,O14745,Q9HB40,Q96B36,Q9NUQ9,P20339,Q8N0X7,Q00535,Q92747 27 +Peripheral nervous system development 0.6234664094725043 1.4814757245672765 0.138479849057967 1.0 0.5646480000543255 8 Q9UPY3,Q9NR77,P11047 3 +Modification of postsynaptic structure 0.650669326382058 1.4813835344923307 0.1385043998533428 1.0 0.5646480000543255 7 P61586 1 +Axonal transport 0.5232225296377128 1.4796292172564611 0.1389722248356335 1.0 0.5646480000543255 16 P27695,Q14203,P04792 3 +Actin filament polymerization 0.4315687973472011 1.4756352682974432 0.1400418319165643 1.0 0.5646480000543255 33 Q9NYL9,Q9NUQ9,Q9UQB8,P62993,Q14247,P35241,Q14019,O15143,O15144,P61586,Q92747 11 +Histone h4 r3 methylation 0.8871627146361407 1.4746814453466217 0.1402982067767832 1.0 0.5646480000543255 2 O14744 1 +Positive regulation of endothelial cell migration 0.522208963740592 1.4736615432284117 0.1405727420740161 1.0 0.565020536103327 16 O75340,P04792,P04083 3 +Histone h3 k4 trimethylation 0.5946955810727705 1.4732944757609174 0.1406716496262454 1.0 0.5650523571662253 9 Q6PD62 1 +Circulatory system development 0.3140980301143645 1.4724313709237706 0.1409044269377115 1.0 0.5653258664316182 119 P04792,Q96T37,Q96PU8,P80723,P78344,P04083,P04179,O14786,Q99873,O95470,P61586,Q96AY3,Q9ULT8,Q5JRA6,P23381,Q06124,P35579,O75340,Q6DKJ4,P30626,Q9HB71,O00151,P35609,P55011,Q05682,Q92688,P35613,P13807,O75592,O95983,Q9H2J4,P11413,P40763,Q07812,Q9BXJ9 35 +Negative regulation of hemopoiesis 0.6483323178163723 1.4708787554987175 0.1413239089352163 1.0 0.5653258664316182 7 P04083 1 +Substrate adhesion dependent cell spreading 0.5003527912508452 1.4705682460352785 0.1414079166992166 1.0 0.5653258664316182 18 P11047,O14786,O15144,P50570,P61586,Q9P258,Q92766 7 +Negative regulation of small molecule metabolic process 0.5386910954594983 1.4697991112391509 0.1416161699504758 1.0 0.5653258664316182 14 P02656,P40763,O60678 3 +Methylation 0.3427462861553771 1.468651520281197 0.141927333109495 1.0 0.5653258664316182 90 Q96T37,O75648,Q9H3P2,Q99873,Q08J23,Q7L2J0,Q9H7B4,Q12824,Q8IZ69,Q99707,Q86X55,P57081,Q8NCA5,Q6PD62,Q5VTR2,Q14353,Q9BV44,O15047,P61964,Q9H9B1,Q8NB78,O60678,O95983,Q69YN4,Q9H993,O14744,Q8N6R0 27 +Negative regulation of peptidyl threonine phosphorylation 0.885527391659853 1.4680489244808643 0.1420909338801053 1.0 0.5653258664316182 2 P0DP25 1 +Regulation of response to external stimulus 0.3322352905752322 1.4674955767964215 0.1422412916369915 1.0 0.5655047510023797 100 Q9NUQ9,P14174,Q9Y5A9,P04792,Q9UMX5,P80303,Q15942,O60828,P04083,Q9BXW9,P19474,P28070,O75592,Q96G23,Q96J02 15 +Muscle organ development 0.4423237282336734 1.4657638860058082 0.1427126227996948 1.0 0.5666530611164357 29 Q9Y5Q8,Q9Y281,P41440,P16989,P30626,P80723,Q9H3U1,Q00535,P61586 9 +Response to epidermal growth factor 0.5375301314326686 1.46329118148096 0.1433877197228361 1.0 0.5670494148710006 14 P51452,Q9UQB8,Q96A49,O75312,Q06124 5 +Cytokine production 0.3492595176119162 1.462055370240031 0.1437260373138029 1.0 0.5670494148710006 79 Q9NUQ9,P14174,O60684,P04792,P41440,O60828,P04083,P19474,P40763,Q02952,Q9UPY3,Q96J02,Q99584 13 +Lipid export from cell 0.8830744071954242 1.4580997605980106 0.1448130473822573 1.0 0.5701802124065973 2 P14174 1 +Negative regulation of calcium ion transport into cytosol 0.7674379126468028 1.4571506021383127 0.1450748128299572 1.0 0.5701802124065973 4 P28161,P0DP25 2 +Negative regulation of ryanodine sensitive calcium release channel activity 0.7674379126468028 1.4571506021383127 0.1450748128299572 1.0 0.5701802124065973 4 P28161,P0DP25 2 +Positive regulation of sequestering of calcium ion 0.7674379126468028 1.4571506021383127 0.1450748128299572 1.0 0.5701802124065973 4 P28161,P0DP25 2 +Negative regulation of lymphocyte activation 0.5439266709767622 1.4556256939519532 0.1454961211927061 1.0 0.5711320560092954 13 O15347,Q96J02,P04083 3 +Somatic diversification of immune receptors via somatic mutation 0.7038345939122168 1.4544880107033766 0.1458110550756419 1.0 0.5716899236591604 5 Q9UQ84 1 +Detoxification of nitrogen compound 0.766421388097698 1.453100472775265 0.1461958598279724 1.0 0.5724314561990599 4 P28161 1 +Negative regulation of peptidyl lysine acetylation 0.6441811433913194 1.452205119259702 0.1464445796975293 1.0 0.5726831485652752 7 Q13363 1 +Cellular component disassembly involved in execution phase of apoptosis 0.6168050040759447 1.4502539298331911 0.1469877210937722 1.0 0.5744454046521873 8 O95831,Q9UPY3 2 +Dicarboxylic acid metabolic process 0.4051717845865973 1.4497176458707586 0.1471372729309228 1.0 0.5746682169188871 39 P34896,P48735,O75874 3 +Regulation of lymphocyte activation 0.3935654057832042 1.4486855009585762 0.1474254313660841 1.0 0.5751343246578251 44 Q9NUQ9,P14174,P04083,Q9BXW9,P61586,P43246,O15347,Q96J02 8 +Negative regulation of cation channel activity 0.6641185936550693 1.44857875964654 0.1474552564382052 1.0 0.5751343246578251 6 P28161,P0DP25 2 +Protein localization to microtubule end 0.8806214227309916 1.448150301318927 0.1475750203293415 1.0 0.5751343246578251 2 Q15691 1 +Vesicle budding from membrane 0.4371969632980668 1.4470843469497383 0.1478733014914883 1.0 0.5751343246578251 30 Q9BVK6,Q15436,Q92734,Q5JRA6 4 +Sulfur compound transport 0.6428332639141086 1.4461380375908222 0.1481384887602019 1.0 0.5751343246578251 7 O00400,Q70HW3 2 +Activation of adenylate cyclase activity 0.8798037612428458 1.4448337815613836 0.1485045797952047 1.0 0.5756187251827231 2 P0DP25 1 +Pyrimidine ribonucleoside monophosphate metabolic process 0.7010946493974276 1.4429815120989176 0.1490256793246274 1.0 0.5761545233816385 5 Q05682,Q9BZX2,P11172 3 +Ump biosynthetic process 0.7010946493974276 1.4429815120989176 0.1490256793246274 1.0 0.5761545233816385 5 Q05682,Q9BZX2,P11172 3 +Positive regulation of cell cycle g1 s phase transition 0.506105092960818 1.4394281389963903 0.1500292565692502 1.0 0.57816873681171 17 P31350,P27695,P35241,P04083,O43660,Q7L2J0,Q04637 7 +Cytoplasmic microtubule organization 0.5477760851768508 1.43730636237882 0.1506309618254728 1.0 0.5789910388571402 12 P61586,Q14203 2 +Dna dealkylation 0.6994428520741314 1.436042011027843 0.1509903873035716 1.0 0.5798703185870004 5 Q9C0B1,P27695 2 +Regulation of mrna catabolic process 0.3521148498917542 1.4356464081114413 0.1511029820805518 1.0 0.5799440783190525 66 Q92945,Q99729,Q9Y2W1,P67809,P98175,Q14011,Q9Y2L1,P08670,Q9Y2V2,O00178,P51116,P16989,Q92900,Q9C0B1,Q6Y7W6,Q9Y5A9,P27695,P35637,Q6P6C2,Q13148,Q8NC51,Q13310,Q92804,Q969T7 24 +Regulation of excretion 0.8765331152902709 1.4315677239269111 0.1522675722060751 1.0 0.582613446333781 2 O14745 1 +Ribonucleoside monophosphate biosynthetic process 0.493703946553145 1.4290231089457583 0.1529975915800432 1.0 0.5843265951488736 18 P22102,P49915,P30085,P30520,Q9BZX2,P07741,Q05682,P27708,P11172,O15067,P55263,P30566,P11908 13 +Pigment cell differentiation 0.7602541670887464 1.428516407306311 0.1531432755222299 1.0 0.5845235039908101 4 Q9BXS5,P04179 2 +Response to mechanical stimulus 0.5310300389104262 1.4268171614817589 0.1536326031926007 1.0 0.5860309986646502 14 P61586 1 +N terminal protein amino acid modification 0.6106217768656691 1.4212299732113929 0.1552499137047354 1.0 0.5876603944386357 8 Q5VZE5,P41227,Q86UY6 3 +Positive regulation of protein deacetylation 0.6957244353405367 1.4204131254742085 0.1554874438273361 1.0 0.5876603944386357 5 Q13363,Q9ULX6 2 +Positive regulation of cellular response to insulin stimulus 0.695218905002726 1.4182875930599632 0.1561068174708675 1.0 0.5876603944386357 5 Q9H1E3,Q06124 2 +Regulation of vascular permeability 0.6570651404838426 1.4177730918088385 0.156257022559751 1.0 0.5876603944386357 6 Q9UDY2 1 +Male meiosis i 0.8728536385936221 1.4166438860446509 0.1565870707092611 1.0 0.5876603944386357 2 Q15645 1 +Cellular iron ion homeostasis 0.5667343714153015 1.4151408336495643 0.1570272078685886 1.0 0.5876603944386357 10 Q15904 1 +Regulation of establishment of protein localization to mitochondrion 0.5501776324654308 1.4147540586222394 0.1571406183386019 1.0 0.5876603944386357 11 P30419,P31689,Q7Z6Z7,P49257,P68036,O14737,Q9BZL1,Q9UII2,P55786 9 +Icosanoid biosynthetic process 0.5666113099446661 1.4145164627111604 0.157210317171113 1.0 0.5876603944386357 10 P14174,P09960,P04083 3 +Mononuclear cell migration 0.4687781853112663 1.4141645426835552 0.1573135960693976 1.0 0.5876603944386357 20 P61586,P04083 2 +Alcohol metabolic process 0.3502344821075341 1.4139727055159836 0.1573699166791686 1.0 0.5876603944386357 66 P48735,P34913,O75874,Q15392,Q9UNW1,P30837 6 +Nuclear body organization 0.7565466448445132 1.4137280801869463 0.157441757291963 1.0 0.5876603944386357 4 Q15637,O75312,Q8NC51 3 +Positive regulation of actin cytoskeleton reorganization 0.7561374795417257 1.412095636314546 0.1579218034575444 1.0 0.5876603944386357 4 O14786,Q00535,Q9UQB8 3 +Cellular response to peptide hormone stimulus 0.3854202237216805 1.4114288244429232 0.1581182087460515 1.0 0.5876603944386357 48 Q9H1E3,O60343,Q9UQB8,P07741,P62993,P27695,P48506,Q9Y5X3,P43490,Q96A49,P40763,P11802,Q06124 13 +Vesicle targeting to from or within golgi 0.5494702554077482 1.4110357901220865 0.1582340611822554 1.0 0.5876603944386357 11 Q92734,Q9BVK6 2 +Bone cell development 0.755271456774934 1.408640225561981 0.1589415780608281 1.0 0.5882964621969957 4 Q15904 1 +Export from cell 0.3303332218861212 1.408593678751411 0.1589553490793074 1.0 0.5882964621969957 98 O43633,P20645,P04083,Q5JRA6,Q06124,P14174,O43768,Q8TAG9,Q8TBQ9,P30626,O95563,Q9UBV2,P15311,P55011,Q99816,Q15042,O75592,Q9Y5K6,O43747,P27695,P20339,Q9UN37,O00471,P0DP25,Q00535,Q99584 26 +Response to hydrogen peroxide 0.4792331553899199 1.4074487523755264 0.1592943634312726 1.0 0.5891709332389538 19 O95831,Q99720,P04083 3 +Tube morphogenesis 0.3450256583800065 1.4052621937647074 0.15994332607811 1.0 0.5907140014025716 78 O75340,Q9H2J4,P04792,Q96T37,Q9BXJ9,P04083,P35613,P40763,P61586,Q96AY3,Q5JRA6 11 +Positive regulation of organic acid transport 0.6916411247237709 1.4032398117035942 0.160545339480076 1.0 0.5921674103913597 5 P14174,Q15042 2 +Cellular response to insulin stimulus 0.3908808584185377 1.40250730858267 0.1607638095788932 1.0 0.5921674103913597 41 Q9H1E3,O60343,Q9UQB8,P62993,P48506,Q9Y5X3,P43490,Q96A49,P11802,Q06124 10 +Actomyosin structure organization 0.4040118593713628 1.4018409879093328 0.1609627357070233 1.0 0.5921674103913597 38 Q9NYL9,Q9Y624,P16949,O14786,Q15149,P61586,P35579,Q99439,P10644,Q8WUM4,Q9NQW6,O00151,P35609,Q9Y281,P60953,P35580,Q7Z460,Q9UN37,Q15942,Q13177 20 +Schwann cell development 0.7534196896295342 1.4012506281073034 0.1611391394779291 1.0 0.5922589752722004 4 Q9UPY3,P11047 2 +Positive regulation of protein polymerization 0.456102470929274 1.4000571712636998 0.1614961989358403 1.0 0.5927254109879246 23 Q15691,P61586,Q14203,Q9UQB8 4 +Macromolecule deacylation 0.4280973715500422 1.3979882991086103 0.1621165809228808 1.0 0.5928965380904019 31 Q13363,P61964,Q9H4L7,Q9ULX6,P49354,Q9UMR5,O95372,Q15014 8 +Multi multicellular organism process 0.45930733135966 1.396131942053206 0.1626747665474561 1.0 0.5935430671326103 22 O60684,P41440,P17655,P35613,P11172,Q13263,Q9UIQ6,Q9BQE5,O75592,Q02790 10 +Cell cycle g1 s phase transition 0.3812091213137132 1.3955278308227437 0.1628567282907345 1.0 0.5935837977749394 50 Q06323,O43660,P04083,Q7L2J0,Q04637,P31350,P35241,Q9UL46,P06730,P49321,Q07864,Q6Y7W6,Q93034,P27695,Q7Z7L1,Q00535,P15927,P11802,O75312,Q8N6R0,Q07666 21 +Response to molecule of bacterial origin 0.4305144627790579 1.3950904296523772 0.1629885717961765 1.0 0.593641660325077 30 Q9NUQ9,P14174,P04179,Q02952,P17655,Q6PD62,P61586 7 +Genitalia development 0.7510810252936079 1.391916013888185 0.163947831947262 1.0 0.5957378796913383 4 Q15392,Q06124 2 +Histone h2b ubiquitination 0.6507639903978562 1.3902184919111211 0.164462539826347 1.0 0.5959777022326241 6 Q9NW82,Q6PD62 2 +Extracellular transport 0.8663123466884721 1.3901159038491988 0.1644936846419835 1.0 0.5959777022326241 2 O14745 1 +Protein trimerization 0.750341272078826 1.3889628940423262 0.1648440336607415 1.0 0.596898804100994 4 P14174 1 +Lipid localization 0.3790790748046547 1.3883858462714394 0.165019583934489 1.0 0.5971862565461403 51 Q99720,P02656,P14174,O43772,P04083,Q9H6V9,Q9C0B1 7 +Lipid homeostasis 0.4869899429237904 1.3869976303516245 0.1654424854094454 1.0 0.5983679874156411 18 P02656 1 +Response to l glutamate 0.7488726040878322 1.383099315757839 0.1666344154746553 1.0 0.5998943145170954 4 O95831 1 +Positive regulation of epithelial cell migration 0.457275101652162 1.3821452283431692 0.1669271136047569 1.0 0.5998943145170954 22 O75340,P04792,P04083 3 +Tricarboxylic acid cycle 0.4636519148238036 1.3799645933135998 0.1675975466937858 1.0 0.6002619565371529 20 P48735 1 +Adipose tissue development 0.5756444828527696 1.379906446399524 0.1676154515225032 1.0 0.6002619565371529 9 P43490,Q8N0X7,Q9C0B1 3 +Peptide catabolic process 0.5750597140599827 1.377034023012223 0.1685017291059312 1.0 0.6002619565371529 9 P55786,Q99829,P09960,Q9UIQ6 4 +Regulation of postsynapse organization 0.5365510323203602 1.377019605392844 0.1685061864730093 1.0 0.6002619565371529 12 P18085,Q9UQB8,Q96HC4,Q14444,Q96QK1,Q00535 6 +Ribonucleoprotein complex localization 0.6853606291197996 1.3768058335240143 0.1685722868032853 1.0 0.6002619565371529 5 Q08J23,Q9ULX6 2 +Organic acid biosynthetic process 0.3443111853133512 1.376399400151709 0.1686980136010274 1.0 0.6002619565371529 69 Q96SU4,P02656,P14174,P49903,Q9UJ14,P34896,Q99707,P09960,P56537,P04083,O60678,Q9NRN7,O60568,P28161,Q14353,Q13126 16 +Anatomical structure formation involved in morphogenesis 0.3088862759661908 1.3761961698012295 0.1687609076104568 1.0 0.6002619565371529 121 O75340,Q96AX1,Q9H2J4,Q06124,P04792,P41440,Q9Y281,Q96T37,Q9BXJ9,P04083,P35613,P40763,Q6PD62,P61586,Q9NR77,Q5JRA6,P23381,Q9UPY3 18 +Regulation of rna binding 0.6006529315932548 1.374358988263255 0.1693302616569352 1.0 0.6002619565371529 8 P60228,Q9H1E3,Q04637 3 +Collagen fibril organization 0.6005906025748933 1.374065663450775 0.1694212980601899 1.0 0.6002619565371529 8 Q96AY3,O60568 2 +Positive regulation of cell cell adhesion 0.4483461845637454 1.373553106884582 0.1695804634138022 1.0 0.6002619565371529 24 P61586,Q9NUQ9,P41440,P04083 4 +Regulation of short term neuronal synaptic plasticity 0.8618152085036808 1.3718820671454388 0.1701001538261275 1.0 0.6002619565371529 2 Q15042 1 +Regulation of filopodium assembly 0.5737040224983302 1.3703736182422437 0.1705703030470857 1.0 0.6008385110407731 9 P20339,O14786,P11233,P51116 4 +Regulation of leukocyte proliferation 0.4943733968160693 1.3681348670040323 0.1712698645721697 1.0 0.6008385110407731 17 P14174,P04083 2 +Establishment of epithelial cell polarity 0.6255068435016099 1.368001693079953 0.1713115461483245 1.0 0.6008385110407731 7 P15311,P60953,P26038,O14745,P61586 5 +Positive regulation of plasma membrane bounded cell projection assembly 0.4731269676805972 1.367995375517025 0.1713135236458582 1.0 0.6008385110407731 19 P50570,Q15555,P27695,Q9UHD8,Q8NCA5,Q9NQW6,O14786,O15144,P60953,P11233 10 +Protein destabilization 0.5989119668149973 1.3661647338596696 0.1718872638268769 1.0 0.6008385110407731 8 P19474 1 +Pyrimidine ribonucleotide biosynthetic process 0.5728455516976907 1.3661552033532665 0.171890254534347 1.0 0.6008385110407731 9 Q9BZX2,Q05682,Q9NRF8,P11172,P17812 5 +Pyrimidine ribonucleotide metabolic process 0.5728455516976907 1.3661552033532665 0.171890254534347 1.0 0.6008385110407731 9 Q9BZX2,Q05682,Q9NRF8,P11172,P17812 5 +Extracellular matrix disassembly 0.6452084049073108 1.365900221722383 0.1719702831527549 1.0 0.6008385110407731 6 P41440 1 +Suppression of viral release by host 0.6823306055322236 1.3640450308594332 0.1725533935311367 1.0 0.6008385110407731 5 P19474,Q14258,Q12899 3 +Microtubule anchoring 0.6246287768000571 1.3640355043075076 0.1725563916605375 1.0 0.6008385110407731 7 O95684,Q14203,Q9P287,Q8IWJ2 4 +Negative regulation of glycolytic process 0.8597710547833206 1.3635955015082517 0.1726949087046367 1.0 0.6008385110407731 2 P40763 1 +Renal system process 0.5723167842211349 1.3635566007935664 0.1727071590171334 1.0 0.6008385110407731 9 P61586,O14745 2 +Regulation of histone h3 k4 methylation 0.5196843176900324 1.3630211943809116 0.172875831094069 1.0 0.6008385110407731 14 Q6PD62,P61964 2 +Protein localization to cell periphery 0.35567854045214 1.3614241027975518 0.173379703442881 1.0 0.6008385110407731 62 Q9Y624,P41440,Q9H4M9,P35241,Q8IWJ2,P35613,Q15904,O00471,Q9H223,P17931,Q00535,O14745,Q9ULT8,Q15436,P35609 15 +Regulation of hematopoietic progenitor cell differentiation 0.5550866084660611 1.3559748791548765 0.175107160967185 1.0 0.6037842696314376 10 O15047,Q96J02 2 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.4324960978009022 1.3553293724350637 0.1753126408097243 1.0 0.6041305777420716 27 Q9UQ84,Q9NUQ9,P40763,P04083 4 +Actin polymerization or depolymerization 0.3945005947443046 1.3547430197691956 0.1754994464165373 1.0 0.6041305777420716 39 Q9NYL9,Q9NUQ9,Q9UQB8,Q9Y281,P62993,Q14247,P35241,Q14019,O15143,O15144,P61586,P35609,Q92747 13 +Regeneration 0.441331611082046 1.3533211493066422 0.1759530555036561 1.0 0.6050213038082528 25 Q99707,P11047,P04083,O14744,Q96G23,Q7Z4V5 6 +Establishment or maintenance of bipolar cell polarity 0.5320591910611514 1.352856474811046 0.1761014866424941 1.0 0.6050753667495875 12 P15311,P18085,P60953,Q8WUM4,O14745,P61586,Q9Y696 7 +Protein kinase c signaling 0.8662815628290887 1.3522614557522226 0.1762916900792235 1.0 0.6050753667495875 3 P41440 1 +Regulation of glial cell proliferation 0.8662280846865029 1.352061968530427 0.1763554923118553 1.0 0.6050753667495875 3 Q9UPY3 1 +Dna conformation change 0.3103083541072212 1.3519761345878487 0.1763829499783704 1.0 0.6050753667495875 110 Q13363,Q8TEX9,P17096,Q9H4L7,P41227,P51530,Q92688,P04083,Q9ULX6,O95831,Q9BRT9,P46063,Q99733,Q9H7B4,Q6PD62,O14646,O15347,Q01105 18 +Hemostasis 0.4813660568214615 1.351747961586118 0.1764559563902581 1.0 0.6050753667495875 18 Q13310,P38435,P04792,Q9Y490 4 +Negative regulation of catabolic process 0.3365720290368484 1.350334349893228 0.1769087587808737 1.0 0.605086860744102 86 P02656,P98175,Q14011,Q04637,Q9H814,Q13526,Q9NRR5,P16989,Q9NQ88,O75592,Q9H2J4,P35637,Q13148,O00273,Q04323,P40763,P46777,Q92804,Q92530 19 +Regulation of voltage gated calcium channel activity 0.6790052001357838 1.350035097856295 0.1770047249195709 1.0 0.605086860744102 5 P0DP25,Q00535 2 +Water soluble vitamin metabolic process 0.5094295697197827 1.3492408704564725 0.1772596111123767 1.0 0.605086860744102 15 P41440,Q9H2D1,Q99707,P48506,P34896,Q9NRN7 6 +Exit from mitosis 0.5951601844072961 1.3484983686184944 0.1774981445230001 1.0 0.6053066872530648 8 Q16763,O43633,Q9UJX2 3 +Negative regulation of phosphoprotein phosphatase activity 0.7398126366130813 1.346912352963161 0.1780084625615008 1.0 0.6062580579232503 4 Q15257 1 +Postsynapse organization 0.4513386720458642 1.34125193090335 0.1798386708519475 1.0 0.6075073143216785 22 P18085,Q9UQB8,Q14247,P12814,Q96HC4,P49354,O14786,Q96QK1,Q00535,P60953,O60678 11 +Regulation of t cell activation 0.4284110683661714 1.3408650793096348 0.1799642618821608 1.0 0.6075073143216785 28 Q9NUQ9,P04083,Q9BXW9,P61586,Q96J02 5 +Ribonucleoside monophosphate metabolic process 0.4475975995421837 1.34053190995391 0.1800724772470379 1.0 0.6075073143216785 23 P22102,P49915,P30085,P30566,Q9BZX2,P30520,P07741,Q05682,P12268,P00491,P11908,Q9UDY2,P11172,O15067,P55263,P00568,P27708 17 +Fat cell differentiation 0.4572887545452649 1.3374583825108208 0.1810730582806674 1.0 0.6075073143216785 20 Q13363,Q8N4Q0,Q9C0B1 3 +3 utr mediated mrna destabilization 0.6385815194447547 1.3368671491722717 0.1812660056177901 1.0 0.6075073143216785 6 Q13148,Q9H2U1,Q92900,Q92945 4 +Peptidyl lysine methylation 0.4143709893423665 1.3361953665165656 0.1814854251610358 1.0 0.6075073143216785 33 Q9H7B4,Q6PD62,O15047 3 +Negative regulation of catalytic activity 0.3052072522778788 1.334126853805778 0.1821622864239305 1.0 0.6075073143216785 119 P02656,P04792,P04083,Q9H7B4,P23381,Q01105,Q15392,P20810,Q15257,P61927,Q99816,Q9P258,P35237,Q96B36,O00273,O95684,Q04323,P17931,P46777,Q92530 20 +Negative regulation of cellular catabolic process 0.3391175797989847 1.3329295005720627 0.1825549403997479 1.0 0.6075449960541787 78 P02656,Q9H2J4,P16989,P35637,Q13148,O00273,Q9H814,Q04323,P40763,P98175,Q9NRR5,Q14011,P46777,Q9NQ88,Q04637,Q92804,Q92530 17 +Morphogenesis of a polarized epithelium 0.5505550274330084 1.332923228706966 0.1825569988143474 1.0 0.6075449960541787 10 P61586,O00471 2 +Regulation of ryanodine sensitive calcium release channel activity 0.6747434094484994 1.3320731777992791 0.1828361432054985 1.0 0.6076364425957442 5 P28161,P0DP25 2 +Release of sequestered calcium ion into cytosol by endoplasmic reticulum 0.6747434094484994 1.3320731777992791 0.1828361432054985 1.0 0.6076364425957442 5 P28161,P0DP25 2 +Histone monoubiquitination 0.5653030164266655 1.3290673468199066 0.1838257519593553 1.0 0.6076364425957442 9 P63208,Q6PD62,Q5VTR2 3 +Folic acid metabolic process 0.6365785969267059 1.328087377726905 0.1841492428023874 1.0 0.6076364425957442 6 P34896,Q9H2D1,P41440 3 +Organic cation transport 0.7350865193869268 1.328027076969217 0.1841691620268117 1.0 0.6076364425957442 4 O43772 1 +Response to corticosteroid 0.4333041839555598 1.3267442786375758 0.1845932884157952 1.0 0.6076364425957442 26 Q99829,P04083,O95831,Q9H7B4,P61586,O75592 6 +Pigment granule organization 0.734334962976402 1.3250235096268868 0.1851633539118791 1.0 0.608346097763096 4 Q9BXS5 1 +T cell selection 0.8588068969310038 1.3243813039279757 0.1853764406028404 1.0 0.6084501565241222 3 P61586 1 +Regulation of response to oxidative stress 0.5042696564435865 1.319460150663876 0.1870153239159786 1.0 0.6116075070646855 15 P04179,P04792 2 +Cellular response to reactive oxygen species 0.4481326055956951 1.3191476384622618 0.1871197595334561 1.0 0.6116075070646855 22 O95831,Q99720,P04083 3 +Negative regulation of transport 0.3675195006737988 1.3185913881917164 0.1873057543081269 1.0 0.6118720327477475 54 Q9NT62,P02656,Q99439,Q9Y376,P04083,P0DP25,O14745,P28161,Q06124 9 +Response to chemokine 0.6713468729496864 1.3177531189776472 0.1875863062631246 1.0 0.6122367776390718 5 P61586,Q96T37 2 +Regulation of glial cell apoptotic process 0.8479149632052365 1.3155601453664123 0.1883217177333418 1.0 0.6132553052564601 2 Q02952 1 +Positive regulation of neurotransmitter secretion 0.8479149632052347 1.3155601453664043 0.1883217177333445 1.0 0.6132553052564601 2 Q15042 1 +Inner cell mass cell proliferation 0.7315875613747899 1.3140428899590808 0.188831771186551 1.0 0.6142720267514311 4 P61201,Q9BRT9,O75312 3 +Nucleoside monophosphate biosynthetic process 0.4472448586619381 1.3130250415574525 0.1891745101806123 1.0 0.6144213955133906 22 P22102,P49915,P30085,Q9BZX2,P30520,P07741,Q05682,P34896,P11172,O15067,P55263,P30566,P11908 13 +Regulation of cell cycle g1 s phase transition 0.417180857830318 1.311742303908777 0.1896070978915389 1.0 0.6149459497777983 31 P31350,P27695,P35241,Q7Z7L1,O43660,P04083,Q8N6R0,Q9UL46,Q7L2J0,Q04637,Q6Y7W6,Q06323,P15927 13 +Unsaturated fatty acid biosynthetic process 0.6130235938102757 1.311570006509178 0.1896652585854736 1.0 0.6149459497777983 7 P04083 1 +Early endosome to golgi transport 0.7307692307692201 1.310772053061736 0.1899347871002494 1.0 0.615281704690949 4 P49257,Q9BVK6,O60749 3 +Negative regulation of cell activation 0.5022071280949302 1.3075504420650843 0.1910258353312968 1.0 0.6167796996192849 15 P17931,O15347,Q96J02,P04083 4 +Dna methylation or demethylation 0.44935932089008 1.3048332860608105 0.1919496221204315 1.0 0.6170294139435747 21 Q9H9B1,P27695,Q8NB78,Q9C0B1,O14744,O95983 6 +Pyrimidine nucleoside monophosphate metabolic process 0.5857623026294471 1.3042057855655125 0.1921634277885464 1.0 0.6170294139435747 8 Q05682,P34896,Q9BZX2,P11172 4 +Pyrimidine nucleoside monophosphate biosynthetic process 0.5857623026294471 1.3042057855655125 0.1921634277885464 1.0 0.6170294139435747 8 Q05682,P34896,Q9BZX2,P11172 4 +Posttranscriptional regulation of gene expression 0.3236868502544562 1.3013291561047322 0.1931458114321789 1.0 0.6172131553212372 190 P04792,Q92945,Q96PU8,P60228,Q9Y2W1,P67809,P78344,P00374,P63173,P98175,Q08J23,P98179,Q14011,Q9Y2L1,P61586,Q04637,Q92600,Q15631,P26196,P34896,Q567V2,Q9H814,P56537,P23588,Q9Y2V2,Q9UPY3,P55010,Q8N543,P51116,P16989,Q7Z478,P55884,Q92900,Q9C0B1,P05198,Q6Y7W6,P43897,Q9Y5A9,P27695,P35637,Q6P6C2,Q13148,Q9UI10,Q8NC51,P04406,P40763,Q13310,P46777,Q15418,Q92804,Q969T7,Q07666 52 +Regulation of dendritic spine morphogenesis 0.5849175071463018 1.3002218813802986 0.1935249331390218 1.0 0.6172131553212372 8 Q96HC4,Q14444,Q00535,Q9UQB8 4 +Interleukin 8 production 0.6095626198327028 1.2959097208415706 0.1950065898035191 1.0 0.6194326970229431 7 P04083 1 +Radial glial cell differentiation 0.8508630796003491 1.2947600852674743 0.1954030052260549 1.0 0.6195607441911267 3 P61586 1 +Viral translational termination reinitiation 0.6287339346290575 1.2936829531692011 0.1957749559314594 1.0 0.6197717151344571 6 P55884,P56537 2 +Establishment of epithelial cell apical basal polarity 0.6287095456959539 1.293575952728555 0.1958119331874082 1.0 0.6197717151344571 6 P15311,O14745,P61586,P60953 4 +Peptidyl glutamic acid modification 0.7260497829465731 1.2919074209673955 0.1963892074764557 1.0 0.62104528709249 4 P41227 1 +Maternal process involved in female pregnancy 0.5827466040011001 1.2899828246444849 0.1970566215261799 1.0 0.62104528709249 8 Q9BQE5,O75592,P35613 3 +Positive regulation of protein modification by small protein conjugation or removal 0.4054625112368723 1.2892590370152823 0.1973080467460279 1.0 0.62104528709249 34 O75340,Q9UBT2,Q7Z6Z7,Q13155,P63208,Q16763,Q9UBV8,Q13526,Q96MG7,P68036,Q5VTR2,Q9BUN8,Q6PD62,O75592,Q9NVI1 15 +Biological adhesion 0.3060459176310415 1.2883187687387712 0.1976350223258625 1.0 0.6214245512119524 127 Q9NYL9,P04792,Q9UQB8,Q9Y624,P04083,P61586,Q5JRA6,Q06124,Q13630,Q8WX93,P31949,P35241,Q9UDY2,Q9UM22,O00151,P35609,P15311,P41440,Q9BTW9,P52565,P35613,Q9Y490,Q9P258,Q92766,Q9Y5K6,Q9NUQ9,Q9Y5A9,Q15942,P11047,P17931,Q00535,Q96J02 32 +Peptidyl proline hydroxylation 0.5821204719115821 1.287029308044539 0.198084073036131 1.0 0.6225213024060596 8 O75718,O15460 2 +Leukocyte apoptotic process 0.5131760863715852 1.2865691515635345 0.1982445016599041 1.0 0.6227103466403666 13 P04083 1 +Ribonucleoside metabolic process 0.6069688689186776 1.2841702759712184 0.1990823830544814 1.0 0.6237646815178254 7 Q13126,P55263 2 +Purine ribonucleoside metabolic process 0.6069688689186776 1.2841702759712184 0.1990823830544814 1.0 0.6237646815178254 7 Q13126,P55263 2 +Rna stabilization 0.4313697169743676 1.2810872389090693 0.2001630255942323 1.0 0.6268342859002436 25 P16989,P35637,Q13148,Q9Y2W1,P67809,Q9H814,P98175,Q08J23,Q14011,Q92804 10 +Negative regulation of rna splicing 0.4798911033774201 1.2799174341067248 0.2005741754436616 1.0 0.6268662221996326 17 P38159,P61978,Q13247,P98175,Q8WXF0,O00422,Q12872,P22626 8 +Histone h3 k4 methylation 0.4456906798450075 1.2799132126373445 0.2005756602736677 1.0 0.6268662221996326 21 Q6PD62,O15047 2 +Platelet morphogenesis 0.6255736100556198 1.279816213190924 0.200609780388133 1.0 0.6268662221996326 6 P35579,Q96AX1,Q06124 3 +Vesicle mediated transport to the plasma membrane 0.4180432264687427 1.278984175722884 0.200902628390291 1.0 0.6268662221996326 29 P42566,Q8TAG9,Q9H4M9,Q8IWJ2,O00471,Q15904,Q9H223,P35609 8 +Production of sirna involved in rna interference 0.8465711855916653 1.278762279490936 0.2009807807406551 1.0 0.6268662221996326 3 Q9UPY3 1 +Regulation of vesicle mediated transport 0.3309239870518637 1.2782853699320724 0.2011488244192159 1.0 0.6270754014273748 86 Q9NT62,P02656,Q7Z3T8,O43633,P04083,Q8N6T3,O14786,O60343,Q99439,P35241,P35609,P15311,P41440,Q9H4M9,Q99816,P61978,Q9H223,Q15042,Q9H3U1,P50570,Q9Y5K6,O43747,P27695,P20339,Q9UN37,P17931,P0DP25,Q00535 28 +Negative regulation of histone acetylation 0.6618200299617375 1.2775700044268377 0.2014010824971472 1.0 0.6272983839067127 5 Q13363 1 +Regulation of inclusion body assembly 0.6614826284863441 1.2761465465586774 0.2019037201214524 1.0 0.6273247210621129 5 P25685 1 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.623664410502093 1.2714377121131373 0.2035729734899849 1.0 0.6290475664075369 6 P35613 1 +Regulation of fat cell differentiation 0.5227419207763395 1.2701929576018136 0.204015905591774 1.0 0.6290475664075369 11 Q8N4Q0,P04179,Q96A49,Q9C0B1,Q92766 5 +Positive regulation of smooth muscle cell apoptotic process 0.8356500408830775 1.26593731568933 0.2055355253160384 1.0 0.6311891301804647 2 P04179 1 +Macromolecule catabolic process 0.2725550270344886 1.265787392721106 0.205589209933918 1.0 0.6311891301804647 338 Q92945,Q99729,Q9Y2W1,P67809,Q99570,Q9UHG3,P06737,Q9NXV2,Q8N511,P28072,P28074,Q9NRR5,P28070,Q9UPY3,O00178,Q99436,P16989,P51665,O95831,Q9C0B1,Q9UIQ6,Q6Y7W6,Q9H2J4,P35637,Q6P6C2,Q04323,Q9UJX2,Q92804,Q969T7,Q96J02,O43633,P62312,Q14011,Q9BUN8,P49721,Q9H814,Q9Y4X5,Q13526,Q9UNZ2,O75592,P20618,Q9Y5A9,O00273,O43242,Q16763,P51530,P48556,Q9UJX4,P25789,Q8TEY7,P25787,Q9Y5X3,P54727,A0AVT1,O95372,Q99816,P07384,Q9Y5K6,Q93034,Q5TBB1,P27695,Q13148,Q13310,Q00535,P46777,P17655,O75312,Q92530,Q9UNS2,Q7Z6E9,P60228,P48506,Q15386,P98175,Q08J23,Q13200,Q9Y2L1,Q9ULT8,P35241,Q9Y2V2,Q9UBV2,Q5VTR2,Q14258,P15311,P51116,P63208,Q92900,O43847,Q9UN37,Q86UV5,Q8NC51,Q96T88,Q5VYK3,P60900,Q07812,Q15008,Q5TDH0,Q8IYB8,Q06323,Q14139 100 +Protein k11 linked ubiquitination 0.6028967615637846 1.265735185506058 0.2056079067553322 1.0 0.6311891301804647 7 Q9UJX2,Q16763,Q9UJX4,P30260 4 +Negative regulation by host of viral transcription 0.7193386920921976 1.2650807320496915 0.2058423891423899 1.0 0.6311891301804647 4 Q9H1E3 1 +Substantia nigra development 0.5021659333732083 1.2642857992349616 0.2061274647352629 1.0 0.6311891301804647 14 P11413,Q04917,P80723,P0DP25,P61586 5 +Regulation of organelle assembly 0.3738816218535554 1.263352552523231 0.2064625077107713 1.0 0.6315922033910788 44 Q9NT62,P15311,O43633,Q15555,P27695,Q99816,P20339,P35241,Q15042,P61586,Q8TC07 11 +Positive regulation of secretion 0.3916756541214935 1.260498480178815 0.2074895958108613 1.0 0.6337975356544264 37 P15311,O43633,P14174,P55011,Q99816,P30626,O43747,P20339,Q9Y5X3,O95563,Q15042,Q00535,Q9Y5K6,Q06124 14 +Negative regulation of molecular function 0.3175542612913682 1.25476609992382 0.2095636822822029 1.0 0.6363767564657603 168 P02656,Q92530,P04792,Q9Y624,P04083,P16949,P19474,Q7L2J0,Q9H7B4,P23381,Q01105,Q8TEY7,O43768,Q9Y376,P30626,Q15392,P20810,P35241,Q13526,Q15257,P61927,P35609,Q9H1E3,Q99816,O14745,Q9P258,P35237,Q96B36,Q99829,O00273,O95684,Q04323,P17931,P0DP25,P46777,P28161,Q96J02 37 +Negative regulation of inclusion body assembly 0.8399157502719756 1.2539658472905104 0.2098544192984233 1.0 0.6366370023660033 3 P25685 1 +Positive regulation of leukocyte cell cell adhesion 0.4752534193832175 1.251639221508637 0.2107013560474442 1.0 0.6388942485618304 17 P61586,Q9NUQ9,P04083 3 +Inclusion body assembly 0.6188863438523837 1.2504656803785337 0.2111294846509985 1.0 0.6392451618734362 6 P25685 1 +Regulation of protein modification process 0.3184024255704146 1.2503391098894632 0.2111756973648435 1.0 0.6392451618734362 238 Q9UBT2,P04792,Q16763,P48506,P19474,Q9H3P2,Q12824,Q9H7B4,Q9BUN8,P61586,Q04637,Q92600,P23381,Q01105,Q06124,Q13363,O75340,P14174,O43768,Q9Y376,Q13526,Q15257,Q6PD62,P54652,O75718,P61927,P61964,P41440,Q99816,Q9NW82,Q9H223,Q96A49,Q15042,O14745,Q9NYV4,O60678,O75592,Q99627,Q96B36,Q9H2J4,P11413,Q13148,O95684,Q9ULX6,Q04323,P49354,P17931,P0DP25,Q00535,P46777,Q9NVI1,Q96J02 52 +Response to peptide 0.3320417517982047 1.2502862276942772 0.2111950075844648 1.0 0.6392451618734362 79 Q9UQB8,P48506,P04083,P43490,Q06124,O60343,P07741,P62993,P56537,Q9Y5X3,P35609,Q9H1E3,Q13247,P09960,P35613,Q96A49,P27695,Q9UI10,Q9NR50,P40763,Q00535,P11802 22 +Protein k29 linked ubiquitination 0.8388548057259698 1.250014543613616 0.2112942346265516 1.0 0.6392451618734362 3 Q16763,Q96J02 2 +Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0.715442666413973 1.2495080152357334 0.2114793237347618 1.0 0.6393800391396647 4 P28161 1 +Response to oxidative stress 0.3325614066508432 1.246172114830871 0.212701214077847 1.0 0.6412012327298204 76 Q99720,Q9NWX6,P04792,O75874,Q15392,P04083,O95831,P28074 8 +Sterol homeostasis 0.5332974264524301 1.245023037249611 0.2131232822360091 1.0 0.6421618547722547 10 P02656 1 +Endothelium development 0.437293694576934 1.2443512272992012 0.2133703249166194 1.0 0.6423670645567259 22 P15311,Q9Y624,P35241,Q9UDY2,O14786,O60568,P18206,O60869,P61586,Q9Y696 10 +Establishment of endothelial barrier 0.5119079629501445 1.2442752696573518 0.2133982695942875 1.0 0.6423670645567259 12 P15311,Q9Y624,P35241,Q9UDY2,P18206 5 +Positive regulation of cytoskeleton organization 0.3928843970687505 1.240091305804975 0.2149416243663342 1.0 0.6456689163544165 36 Q9UHV9,Q9UQB8,Q9Y281,P62993,Q14247,Q14203,Q15691,O14786,O15144,Q00535,P61586,P35609 12 +Vesicle organization 0.3445773744701769 1.2389646515914816 0.2153585890460851 1.0 0.6457638039479425 62 O43633,Q92734,Q5JRA6,Q9BVK6,P04083,Q9BXS5,Q15436,Q15075 8 +Cellular pigmentation 0.5967565297499161 1.2379298770210458 0.2157420630122128 1.0 0.6462895375329677 7 Q96AX1,Q9BXS5 2 +Immune system development 0.3056370299358866 1.2347201772499712 0.2169346638394687 1.0 0.6486106222643719 134 Q9NYL9,Q96T37,Q9UQ84,P04179,P04083,Q15904,P55327,Q99873,P61586,Q9ULT8,P43246,Q6FI81,Q06124,Q99439,P56537,Q9NQW6,Q6PD62,O15047,Q9NPH0,Q9H3U1,P11413,Q9Y5A9,Q6NXE6,Q9BXW9,P40763,P17931,Q13310,Q96AX1,O15347,Q96J02 30 +Negative regulation of dna binding transcription factor activity 0.4626800786457624 1.234425408841208 0.2170444257589237 1.0 0.6486265081630973 18 P19474 1 +Positive regulation of mitotic cell cycle phase transition 0.4097432264326854 1.2330053531264884 0.2175737669809634 1.0 0.6495832177652803 30 Q9NYL9,P31350,P30260,P11802,P27695,P35241,O43660,P04083,Q9UJX4,Q9UJX2,Q7L2J0,P54652,Q04637,Q9P258 14 +Negative regulation of mrna splicing via spliceosome 0.4889246401350794 1.2308041105355203 0.2183961378002408 1.0 0.6505580915662624 15 P38159,P61978,Q13247,P98175,Q8WXF0,O00422,Q12872 7 +Establishment of endothelial intestinal barrier 0.6142927230212458 1.23030016277195 0.2185847233957258 1.0 0.6505580915662624 6 Q9UDY2 1 +Regulation of cell communication by electrical coupling involved in cardiac conduction 0.8266557645134934 1.229610135951899 0.2188431325735784 1.0 0.6505580915662624 2 P0DP25 1 +Regulation of high voltage gated calcium channel activity 0.8266557645134934 1.229610135951899 0.2188431325735784 1.0 0.6505580915662624 2 P0DP25 1 +Regulation of non motile cilium assembly 0.6134316134316268 1.2265198215204791 0.2200031208482544 1.0 0.6527565124069089 6 Q15555,P27695,P27816,Q9UHD8,P50570 5 +Peptidyl lysine hydroxylation 0.7094711551811594 1.2256437476757518 0.2203327673182646 1.0 0.6531104940555722 4 Q96AY3 1 +Response to steroid hormone 0.3495668840344373 1.225098755458918 0.2205380140479742 1.0 0.653346545606455 59 Q99829,O75874,P04083,O95831,Q9H7B4,P61586,O75592,Q02790 8 +T cell lineage commitment 0.6487903365550264 1.2225939302986402 0.2214831067847087 1.0 0.6551666069317303 5 P61586 1 +Regulation of epithelial cell migration 0.4031762522465484 1.2220376968442392 0.2216933718115943 1.0 0.6552669390528324 32 O75340,P61586,P04792,P04083 4 +Regulation of ubiquitin protein ligase activity 0.5280343341764624 1.2181966396027888 0.2231492563523103 1.0 0.6570682228297047 10 Q16763,P61927,P46777 3 +Negative regulation of gtpase activity 0.6106662029934793 1.2143794121057183 0.2246028734938028 1.0 0.6579169077342054 6 Q9P258,Q9Y624 2 +Positive regulation of mirna mediated gene silencing by inhibition of translation 0.8274028629856802 1.2073966683313824 0.2272794180075248 1.0 0.6641906756831666 3 Q04637,P40763 2 +Cellular response to molecule of bacterial origin 0.4346539753212094 1.204904754355096 0.2282400730187448 1.0 0.6663708760913989 21 Q9NUQ9,P14174,P17655,Q6PD62,P61586 5 +Positive regulation of ryanodine sensitive calcium release channel activity 0.8264560428294914 1.2038762108285277 0.2286374277767153 1.0 0.6665262492729174 3 P28161 1 +Pyrimidine ribonucleoside triphosphate metabolic process 0.5891857207612681 1.2036412206586524 0.2287282800492323 1.0 0.6665262492729174 7 Q9BZX2,P17812,Q9NRF8 3 +Pyrimidine ribonucleoside triphosphate biosynthetic process 0.5891857207612681 1.2036412206586524 0.2287282800492323 1.0 0.6665262492729174 7 Q9BZX2,P17812,Q9NRF8 3 +Protein k63 linked ubiquitination 0.4979797296045777 1.2027941710173462 0.2290559810305548 1.0 0.6668640439049124 13 Q16763,P19474,Q96J02 3 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.8253578732106296 1.1997936761502523 0.2302194807922206 1.0 0.6682728236368348 3 O60678,Q99873 2 +Histone arginine methylation 0.8253578732106287 1.199793676150249 0.230219480792222 1.0 0.6682728236368348 3 Q99873,O14744 2 +Gmp metabolic process 0.503225630318431 1.1974499434432513 0.2311312270608927 1.0 0.668707800780569 12 Q9UDY2 1 +Phospholipase c activating g protein coupled receptor signaling pathway 0.818479149632055 1.1966445745518228 0.23144511875764 1.0 0.668707800780569 2 O14745 1 +Regulation of endocytic recycling 0.8184791496320538 1.1966445745518184 0.2314451187576418 1.0 0.668707800780569 2 Q9H4M9 1 +Positive regulation of endocytic recycling 0.8184791496320538 1.1966445745518184 0.2314451187576418 1.0 0.668707800780569 2 Q9H4M9 1 +Negative regulation of fat cell differentiation 0.7021330425178027 1.1963301593707938 0.2315677438884447 1.0 0.668707800780569 4 Q8N4Q0 1 +Regulation of protein kinase activity 0.3286143206299352 1.1960528285889085 0.2316759440171343 1.0 0.668707800780569 75 Q99627,Q96B36,P14174,P04792,Q9Y376,Q99816,Q9NYV4,O95684,Q96A49,P0DP25,O14745,Q9H7B4,P61586,P23381 14 +Hematopoietic stem cell differentiation 0.5083823065415929 1.1943740197155668 0.2323316948901135 1.0 0.6699711345944294 11 O15047,Q96J02 2 +Neuron differentiation 0.3115185486721837 1.192707211110461 0.2329840605014621 1.0 0.6710718996818552 159 Q8WUJ1,Q9UQB8,Q15428,O60828,P78344,P04179,P00374,P16949,O14786,Q99873,P61586,P08670,Q04637,P33176,Q06124,Q8TEY7,Q8WX93,Q15555,Q04917,O60271,Q14247,P26196,Q99707,Q9BUP0,Q9BW83,Q96HC4,Q13526,Q86X55,Q9Y296,P61201,Q9UPY3,Q9NR77,A0AVT1,O95372,Q02790,P55145,P18085,P61964,P41440,Q9H4M9,Q9BTW9,P35613,Q9UBB4,O14745,P50570,Q6Y7W6,O60678,O75592,Q96G23,Q99829,P11047,Q8N0X7,P40763,Q00535,O75312 55 +Positive regulation of muscle cell differentiation 0.6416309910948457 1.1923914083361622 0.2331078075570354 1.0 0.6711170537455678 5 Q15014 1 +Regulation of phosphatase activity 0.4957946681380478 1.1907474647168614 0.2337527384148083 1.0 0.6721097167166077 13 P0DP25,Q15257 2 +Positive regulation of fibroblast proliferation 0.641144279219735 1.190338549625301 0.2339133549666447 1.0 0.6721097167166077 5 P11802,P14174,Q5TBB1 3 +Regulation of p38mapk cascade 0.8168438266557663 1.1900592258937874 0.2340231146621365 1.0 0.6721097167166077 2 Q99873 1 +Type b pancreatic cell apoptotic process 0.6410308449535258 1.1898601144057468 0.2341013773959803 1.0 0.6721097167166077 5 Q13247,P20810 2 +Cell activation 0.3075967480808662 1.1898585726887432 0.2341019834553981 1.0 0.6721097167166077 104 P04792,Q9Y624,Q9UQ84,P48506,P04083,P55327,P61586,P43246,P17812,Q06124,P14174,Q02952,Q9Y490,Q9NUQ9,Q9BXW9,P40763,P17931,O14744,O15347,Q96J02,Q99584 21 +Smooth muscle cell proliferation 0.4741633800122029 1.189453964321533 0.2342610761848487 1.0 0.6722556761127128 16 P61586,Q5VZE5,P04179 3 +Positive regulation of transport 0.2990917021996335 1.1869684906021527 0.2352400494606716 1.0 0.6744416930520643 126 O43633,P04083,Q06124,P14174,P30626,P35241,Q9Y5X3,O95563,P54652,P35609,P15311,P55011,P41440,Q9H4M9,Q99816,P61978,Q92688,O14737,Q15042,O14745,P50570,Q9Y5K6,O43747,P11413,P27695,P20339,Q13148,Q9UN37,P17931,P0DP25,Q00535,Q07812,Q13263,P55786,P28161,O75312 36 +Negative regulation of innate immune response 0.5068383396558953 1.1862217116765963 0.235534754173456 1.0 0.6746636639378054 11 P19474 1 +Tubulin complex assembly 0.6398148008746485 1.1847313941125943 0.2361236656409933 1.0 0.6757271721799855 5 P61758,Q15813 2 +Iron ion homeostasis 0.4808745755953587 1.1842804430606493 0.2363020677990008 1.0 0.675926228020173 15 Q15904,Q8N511 2 +Regulation of cell projection assembly 0.378965273786389 1.182126323860614 0.2371555808185954 1.0 0.6768066255360429 38 Q9NT62,Q15555,P51116,P27695,P20339,P35241,Q9P258,Q8NCA5,Q9NQW6,O14786,O15144,P50570,Q8TC07,P11233 14 +Lamellipodium morphogenesis 0.6977679950982304 1.1789021913172302 0.2384371250696864 1.0 0.678120845528349 4 Q92766,O60749 2 +Negative regulation of rna catabolic process 0.4049789718496033 1.1782241092124974 0.2387072734822819 1.0 0.678120845528349 29 P16989,P35637,Q13148,Q99729,Q9Y2W1,P67809,Q9H814,P98175,Q08J23,Q14011,Q92804 11 +Cell cycle dna replication initiation 0.6380303650880738 1.1772062688942342 0.2391131871343379 1.0 0.6789633708752805 5 P09884,P33993,P33991 3 +Regulation of insulin receptor signaling pathway 0.534306006553682 1.176388580349872 0.239439632982779 1.0 0.6790889237625914 9 Q9H1E3,Q06124,Q9Y5X3 3 +Establishment of golgi localization 0.6959901800327234 1.171806472353676 0.2412747635471159 1.0 0.6803757349297211 4 O14745,P63104,P60953 3 +Synaptic vesicle transport 0.5332203048201472 1.1710400268346293 0.2415826884895386 1.0 0.6803757349297211 9 Q9Y2T2,Q00535,P50570 3 +Positive regulation of protein binding 0.4322622973360702 1.1699777230387542 0.242009933811454 1.0 0.681270031264338 20 Q15691,Q9BUN8,P19474,P41440 4 +Regulation of phosphoprotein phosphatase activity 0.5034248731773997 1.1682003621919086 0.2427259544372915 1.0 0.682976065725229 11 P0DP25,Q15257 2 +Regulation of cytoskeleton organization 0.3116830732216664 1.1669599137165767 0.2432265583766482 1.0 0.6837650192480694 99 O43633,Q9NYL9,Q9UHV9,Q9UQB8,Q9Y624,Q14203,Q14019,P16949,O15143,P61586,Q15555,P62993,P35241,P35609,Q02790,P15311,Q9Y281,P52565,Q9Y5K6,O75592,Q9NUQ9,Q15691,Q00535,P17655,Q92747 25 +Regulation of mitotic centrosome separation 0.8159509202453964 1.164855030757083 0.2440776788966439 1.0 0.6841755172605354 3 P52732,Q9UNZ2 2 +Positive regulation of organelle assembly 0.4515974968019891 1.164801765317177 0.2440992441582874 1.0 0.6841755172605354 18 A5YKK6,Q15555,Q14204,P27695,P26038,Q8WUM4,Q9UHD8,Q9UN86,Q15042,Q16181,P61586,Q13283 12 +Tight junction organization 0.4971505644753824 1.1646917449972167 0.2441437916665614 1.0 0.6841755172605354 12 Q9Y624,P17612,Q8WUM4,Q9BTW9,Q13177,Q15149 6 +Transport of virus 0.5989204582049236 1.1628242647651033 0.2449008101604346 1.0 0.6844437583691715 6 O60684 1 +Regulation of protein targeting 0.4767694528334705 1.16056341643016 0.245819490129461 1.0 0.6852315263446039 15 Q9Y4C2,P31150,Q7Z6Z7,P49257,P68036,O14737,Q9BZL1,Q00535,Q9UII2,P55786 10 +Establishment of protein localization 0.2514904195403887 1.1585299278693293 0.2466478457571737 1.0 0.6861496872845071 377 Q9NT62,Q9NVZ3,O43633,P61009,O60684,Q8TEX9,P04792,Q7Z4Q2,Q9NPA0,Q92973,O76094,P20645,P04083,Q15904,Q8N6T3,Q9H7B4,Q9BUN8,O60830,Q5JRA6,O75340,A6NIH7,Q8TAG9,Q8TBQ9,P40616,Q9H814,Q9BW83,O95563,P35606,P20290,Q92688,O95831,Q15042,Q9BXS5,P83436,O75592,Q96AX1,P20339,Q9BVK6,O00471,Q8NFH4,P40763,P0DP25,O43592,P55786,Q9UHB9,Q15436,Q99584 47 +Organophosphate catabolic process 0.4180174844492014 1.157302580831374 0.2471487594828112 1.0 0.6868935036913267 24 Q9H773 1 +Endocytic recycling 0.4896973796090183 1.1571396860104302 0.2472152948067818 1.0 0.6868935036913267 13 Q15904,P42566,Q9H223,Q9H4M9 4 +Negative regulation of intracellular signal transduction 0.3245071203058938 1.1542679046400623 0.2483903506295366 1.0 0.6880729554950767 78 O75340,Q96B36,Q9NUQ9,P14174,P04792,P16989,P04179,Q13526,O14745,P61586,Q96J02 11 +Regulation of clathrin dependent endocytosis 0.8078495502861831 1.1538923682364868 0.2485442984292556 1.0 0.6880729554950767 2 Q9H3U1 1 +Response to hormone 0.3043067763749383 1.1532171634567323 0.2488212604470778 1.0 0.6880729554950767 144 Q9UQB8,O75874,P48506,P04083,P43490,O15143,Q9H7B4,P61586,Q92600,Q06124,O60343,P07741,Q9Y376,P62993,Q15392,P35241,Q86X55,P56537,Q9Y5X3,Q14258,Q02790,Q9H1E3,Q13247,P09960,P35613,O95831,Q96A49,O75592,Q99829,P27695,Q9UI10,Q9NR50,P40763,P0DP25,P11802 35 +Positive regulation by host of viral transcription 0.5963935617815872 1.1517376506096348 0.249428895673657 1.0 0.6880729554950767 6 Q9H1E3,O14646 2 +Organelle membrane fusion 0.4394960296672143 1.1501614003906204 0.250077401055135 1.0 0.6880729554950767 19 Q8IWA4,Q15075,P04083 3 +Positive regulation of histone ubiquitination 0.6893181892640675 1.1451917315213862 0.2521297427587867 1.0 0.6902813648065771 4 Q6PD62 1 +Type i interferon production 0.4160506298763838 1.1432767295604267 0.2529237135177411 1.0 0.6907790264989724 24 P19474,O60828,Q96J02,P41440 4 +Protein complex oligomerization 0.3543848017659151 1.1429175252993988 0.2530728354526759 1.0 0.6907790264989724 51 Q99720,O43633,P14174,Q9NWX6,P35637,P34896,P04179,Q9NXV2 8 +Negative regulation of dephosphorylation 0.5130381323179185 1.1417758796974296 0.25354719078191 1.0 0.6907790264989724 10 P17931,Q15257 2 +Regulation of mrna metabolic process 0.2979583130228087 1.14131781238336 0.2537376923062688 1.0 0.6907790264989724 130 Q96T37,Q92945,Q96PU8,Q99729,Q9Y2W1,P67809,Q15637,P98175,Q8WXF0,P98179,Q14011,Q9Y2L1,P08670,O00267,Q96EP5,Q12872,Q9Y2V2,Q6PD62,Q5VTR2,O00178,P51116,P16989,P61978,Q13247,Q92900,Q9C0B1,Q6Y7W6,Q69YN4,Q9Y5A9,P27695,P35637,Q6P6C2,Q13148,Q8NC51,Q8N684,Q13310,Q92804,Q969T7,Q07666 39 +Protein k48 linked ubiquitination 0.5753652652260384 1.141067521002296 0.2538418258406851 1.0 0.6907790264989724 7 Q15386,Q96J02 2 +Maintenance of cell polarity 0.5931357151172187 1.137447864119585 0.2553511077825288 1.0 0.6933670220067791 6 O00151,O14745 2 +Cellular modified amino acid metabolic process 0.3570761896465535 1.1363876532284936 0.255794360815383 1.0 0.6936606902460822 48 P11413,O75874,Q9UJ14,P41440,P34896,P48506,Q9H2D1,P04179,Q9NRN7,O60568,Q9UHG3,P28161,Q14353 13 +Negative regulation of chemotaxis 0.6280163728463373 1.1350002322679311 0.2563752210590415 1.0 0.6946291984191308 5 O14786,P51452,P14174 3 +Receptor mediated endocytosis 0.360843495545797 1.1345077451887355 0.2565816267422034 1.0 0.694885260387738 43 P42566,P09497,P02656,P15311,Q01518,P62993,P61978,P41440,P20339,P20645,Q9H3U1,P50570,Q9UBF8,Q9Y5K6 14 +Mature ribosome assembly 0.6272722742307891 1.1318660918977097 0.257690736198326 1.0 0.6955376349461347 5 Q7Z2Z2,P56537 2 +Negative regulation of stem cell differentiation 0.5733291513381247 1.131854436899074 0.2576956369567509 1.0 0.6955376349461347 7 Q8WX92,P40763,Q9Y5A9 3 +Golgi localization 0.6272105844193617 1.1316062693888045 0.2578000031511687 1.0 0.6955376349461347 5 O14745,P63104,P60953 3 +Negative regulation of nucleotide metabolic process 0.8063308093506663 1.1291950763262442 0.2588155503158698 1.0 0.6955376349461347 3 P40763 1 +Endothelial cell development 0.463889818247984 1.1286054707397568 0.2590643018524969 1.0 0.6955376349461347 16 P15311,Q9Y624,P35241,Q9UDY2,P18206,O60568,Q9Y696 7 +Methionine metabolic process 0.8058306868883439 1.12734344756988 0.2595972994292661 1.0 0.6955376349461347 3 Q99707 1 +Sulfur amino acid biosynthetic process 0.8058306868883439 1.12734344756988 0.2595972994292661 1.0 0.6955376349461347 3 Q99707 1 +Methionine biosynthetic process 0.8058306868883439 1.12734344756988 0.2595972994292661 1.0 0.6955376349461347 3 Q99707 1 +Regulation of organic acid transport 0.5722111219792605 1.126796445911714 0.2598285535399354 1.0 0.6955376349461347 7 P14174,Q15042 2 +Dna unwinding involved in dna replication 0.4839998665041686 1.1257536634516287 0.2602698022884522 1.0 0.6962427299875125 13 P27694,P17096,P33991,Q9BRT9,P46063,P33993,P25205 7 +Lipoprotein metabolic process 0.4897818736909514 1.1249808259924363 0.2605971594100669 1.0 0.6962427299875125 12 P02656,Q9BQE5,Q15042 3 +Smooth muscle cell apoptotic process 0.8051237088468868 1.124726370890114 0.2607050033567741 1.0 0.6962427299875125 3 P04179 1 +Inner cell mass cell differentiation 0.8004905968928917 1.1243754274254822 0.2608537919449933 1.0 0.6962427299875125 2 Q6PD62 1 +Mitochondrial fragmentation involved in apoptotic process 0.625411193584046 1.1240287010542132 0.2610008502912748 1.0 0.6962427299875125 5 Q9NT62,Q07812 2 +Regulation of calcium ion transmembrane transport 0.4629777499124805 1.1232075420815637 0.2613493601562742 1.0 0.6968568169044493 16 P11413,P27695,P30626,P0DP25,Q00535,P54652,P28161 7 +Abscission 0.8000817661488163 1.1227377560356284 0.2615488876887357 1.0 0.6969864942025314 2 Q8N0X7 1 +Negative regulation of smooth muscle cell proliferation 0.6250634624990443 1.122564577423495 0.2616224666644284 1.0 0.6969864942025314 5 P61586,P04179 2 +Positive regulation of glial cell differentiation 0.58930014042637 1.1206307297460578 0.2624450789179962 1.0 0.6979802741245209 6 Q9UPY3 1 +Proteasome mediated ubiquitin dependent protein catabolic process 0.3102401180281799 1.1199827774519162 0.2627211013434962 1.0 0.6983593142978892 97 Q92530,Q16763,P48506,P48556,Q9UJX4,Q13200,Q9BUN8,Q9ULT8,Q9NXV2,P30260,P25787,Q9Y4X5,Q99460,Q9UBV2,Q9NRR5,P54727,Q14258,Q9UNZ2,P63208,P46379,P45974,P51665,O15372,Q9Y5K6,Q93034,Q04323,Q5VYK3,Q9UJX2,Q15008,Q96J02,Q14139 31 +Negative regulation of type b pancreatic cell apoptotic process 0.6822478548102122 1.1170189177217982 0.2639862366119014 1.0 0.699980584696801 4 Q13247 1 +Response to lipid 0.2901492579030597 1.116678258025834 0.264131917318299 1.0 0.7000503186806811 113 P14174,Q99829,O75874,P04179,P04083,O95831,P40763,Q02952,Q9H7B4,P61586,Q6PD62,O75592,Q13126,Q02790 14 +Cellular response to steroid hormone stimulus 0.3589104025202268 1.1164302882747563 0.2642379946839801 1.0 0.7000503186806811 43 Q9H7B4,P61586,P04083 3 +Negative regulation of protein dephosphorylation 0.5456719598140956 1.1150516163029087 0.2648283034345104 1.0 0.7013150380930959 8 P17931,Q15257 2 +Response to reactive oxygen species 0.4080132913438607 1.111591726942588 0.2663137312267136 1.0 0.702837321809345 25 O95831,Q99720,P04083 3 +Ovulation cycle 0.586686858687922 1.1091776878989104 0.2673535359204979 1.0 0.703800533304914 6 P04083 1 +Mrna splice site selection 0.4230304412184746 1.1082247751166312 0.2677647536484768 1.0 0.7043060991179251 20 Q15428,Q15637,Q8WXF0,Q13247 4 +Positive regulation of muscle cell apoptotic process 0.6215546853361267 1.107795466101443 0.2679501586092976 1.0 0.7043060991179251 5 Q9NQ88,P04179,P17655 3 +Regulation of vesicle fusion 0.8005160430389373 1.107681839443131 0.2679992451232942 1.0 0.7043060991179251 3 P04083 1 +Regulation of pigmentation 0.7959934587080977 1.106374401239514 0.2685645006935551 1.0 0.7046792773870797 2 Q96AX1 1 +Mammary gland involution 0.7959934587080969 1.10637440123951 0.2685645006935568 1.0 0.7046792773870797 2 P07384 1 +Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c 0.7959934587080969 1.10637440123951 0.2685645006935568 1.0 0.7046792773870797 2 Q9NR28 1 +Regulation of lipid biosynthetic process 0.4141986236018114 1.1063035752073571 0.2685951448591333 1.0 0.7046792773870797 23 P02656,O75874 2 +Organism emergence from protective structure 0.7994380285089986 1.1036972154918856 0.2697245039276408 1.0 0.7060371179790366 3 Q6PD62 1 +Regulation of genetic imprinting 0.7951757972199565 1.103104731213291 0.269981686475365 1.0 0.7060371179790366 2 Q6PD62 1 +Genomic imprinting 0.7951757972199565 1.103104731213291 0.269981686475365 1.0 0.7060371179790366 2 Q6PD62 1 +Embryonic placenta morphogenesis 0.7951757972199529 1.1031047312132776 0.2699816864753708 1.0 0.7060371179790366 2 P62993 1 +Bleb assembly 0.7992504722377032 1.1030040841426882 0.2700253915483146 1.0 0.7060371179790366 3 Q9NR77 1 +Regulation of t cell receptor signaling pathway 0.6783960720130868 1.101686986550782 0.2705977764235594 1.0 0.7062656334902255 4 P51452,P17931,P15311 3 +Regulation of antigen receptor mediated signaling pathway 0.6783960720130868 1.101686986550782 0.2705977764235594 1.0 0.7062656334902255 4 P51452,P17931,P15311 3 +Regulation of hepatic stellate cell activation 0.794358135731809 1.0998360927919002 0.2714035434150601 1.0 0.7062656334902255 2 P48506 1 +Regulation of lipid metabolic process 0.3576333617552366 1.0995873292847889 0.2715119651308066 1.0 0.7062656334902255 42 P02656,P34913,O75874 3 +Regulation of cilium assembly 0.4792319675152831 1.0995093870891446 0.2715459417569517 1.0 0.7062656334902255 13 Q9NT62,Q8TC07,Q15555,P27695 4 +Regulation of cellular amide metabolic process 0.3061363048293494 1.097903464660711 0.2722466449250689 1.0 0.7064988152882063 161 P04792,Q92945,Q96PU8,P60228,P67809,P78344,P00374,P63173,P98179,Q14011,Q9Y2L1,P61586,Q04637,Q92600,P26196,P34896,Q567V2,P56537,Q13526,P23588,P55010,Q8N543,P51116,P16989,Q7Z478,P55884,Q92900,Q9C0B1,P05198,Q9NQ88,Q6Y7W6,P43897,Q9Y5A9,P27695,Q13148,Q9UI10,P04406,P40763,P18669,P46777,Q15418,Q969T7,Q07666 43 +Negative regulation of protein acetylation 0.5179658500894567 1.0959530658464258 0.2730993144288496 1.0 0.7075288871936404 9 Q13363 1 +Dendrite development 0.3846015552742518 1.0941297673072892 0.2738980686950332 1.0 0.7085690654265766 33 P18085,Q9UQB8,Q04917,O60828,P78344,Q86X55,Q96HC4,O14786,Q00535,Q9Y296,P60953,P61586,A0AVT1,O60678 14 +Regulation of cellular component size 0.3223718747018051 1.092956401392433 0.2744129426730333 1.0 0.7085690654265766 66 Q9NYL9,Q9UQB8,Q14019,P78344,O15143,O14786,O15144,P61586,P62993,Q14247,P35241,P35609,P15311,Q9Y281,P55011,P50570,O14745,Q96B36,Q9NUQ9,P20339,Q8N0X7,Q00535,Q92747 23 +Gmp salvage 0.796374037825668 1.0923787432106369 0.2746666622808507 1.0 0.7085690654265766 3 P55263 1 +Regulation of apoptotic dna fragmentation 0.7963190184049008 1.0921755946419018 0.2747559274633167 1.0 0.7085690654265766 3 O95831,O00273 2 +Regulation of dna catabolic process 0.7963190184049008 1.0921755946419018 0.2747559274633167 1.0 0.7085690654265766 3 O95831,O00273 2 +Purine nucleobase biosynthetic process 0.5398084548406836 1.0874303604742648 0.2768466596636787 1.0 0.7114394722115674 8 P34896 1 +Organic cyclic compound catabolic process 0.2993202138269896 1.0863520586732287 0.2773232632462434 1.0 0.7114394722115674 142 Q9H773,P34913,Q92945,Q99729,P60228,P51530,Q9Y2W1,P67809,P62312,P98175,Q08J23,Q14011,Q9Y2L1,P08670,Q04917,Q9H814,Q9Y2V2,Q9UPY3,O00178,P51116,P16989,Q92900,O95831,Q9C0B1,Q6Y7W6,Q13126,Q5TBB1,Q9Y5A9,P27695,P35637,Q6P6C2,O00273,Q13148,Q8NC51,Q8IYB8,Q9NRN7,Q13310,Q07812,O75312,Q92804,Q969T7 41 +Hepatic stellate cell activation 0.7946830265848629 1.086136582348394 0.2774185695855315 1.0 0.7114394722115674 3 P48506,Q02952 2 +Fibroblast activation 0.7946830265848629 1.086136582348394 0.2774185695855315 1.0 0.7114394722115674 3 P48506,Q02952 2 +Oligosaccharide lipid intermediate biosynthetic process 0.7945550372895925 1.0856642591004435 0.2776275587457619 1.0 0.7114394722115674 3 O75340 1 +Membrane fusion 0.3925292824304792 1.0822960914782829 0.2791209821690943 1.0 0.7126426802518064 29 Q8IWA4,Q9UNZ2,Q15075,P04083 4 +Glycine biosynthetic process 0.7932603026654369 1.0808873315359375 0.2797472345593039 1.0 0.7129620275575481 3 P34896 1 +Negative regulation of response to wounding 0.6730769230769091 1.0805358963956018 0.2799036108188879 1.0 0.7129620275575481 4 Q7Z460,Q96G23,P55011 3 +Keratinocyte proliferation 0.6730769230769087 1.0805358963955989 0.2799036108188892 1.0 0.7129620275575481 4 Q13247,Q15648,Q6ZWJ1 3 +Regulation of keratinocyte proliferation 0.6730769230769087 1.0805358963955989 0.2799036108188892 1.0 0.7129620275575481 4 Q13247,Q15648,Q6ZWJ1 3 +Nucleobase metabolic process 0.4186870506556698 1.0792078175085975 0.2804950954954293 1.0 0.7138830094371376 20 P30085,P07741,Q05682,P34896,Q9NRF8,P11172,P17812 7 +Positive regulation of metaphase anaphase transition of cell cycle 0.5796057712468088 1.078168536413269 0.2809585503883072 1.0 0.7147696017662383 6 Q9UJX4,Q9UJX2,P30260 3 +Endosomal transport 0.3489114248828521 1.077247175948152 0.2813698545055927 1.0 0.7151399317240948 50 O43633,Q7Z3T8,Q14203,O60749,Q9P2R3,Q15904,Q15075,P42566,O60271,P40616,Q8IWJ2,Q9Y5X3,P35609,Q9H4M9,P49257,Q9H223,Q6IAA8,Q96D71,Q9UN37,Q9BVK6 20 +Vesicle targeting 0.4465659931920253 1.076836461289567 0.2815533330655113 1.0 0.7151399317240948 17 Q92734,Q9BVK6 2 +Dna modification 0.4065332465789643 1.0754755708683157 0.2821618637028331 1.0 0.7153562456194827 24 Q9H9B1,P27695,Q8NB78,Q9C0B1,O14744,O95983 6 +Positive regulation of i kappab kinase nf kappab signaling 0.3952890204842842 1.0754612562766768 0.2821682692983276 1.0 0.7153562456194827 27 P61586,P19474,Q92734,Q99584 4 +Pyrimidine containing compound biosynthetic process 0.4685848273140767 1.0749726006429694 0.2823869955472808 1.0 0.7153562456194827 14 Q9BZX2,Q05682,P34896,Q9NRF8,P11172,P17812 6 +Sulfur amino acid metabolic process 0.5603900628379629 1.073369181904846 0.2831055061427336 1.0 0.7155543532434278 7 Q13867,Q99707,P48506,Q13126 4 +Vacuolar localization 0.4852100997111861 1.072153995243306 0.2836508698465543 1.0 0.7155543532434278 11 P35579,O60271,Q8NCA5,Q96AX1,P33176,Q99584 6 +Positive regulation of mitotic cell cycle 0.3664135590979706 1.0720751431404965 0.283686282450633 1.0 0.7155543532434278 38 P51452,Q9NYL9,P31350,P30260,P11802,P27695,P35241,P06730,O43660,P04083,Q9UJX4,Q9UJX2,Q7L2J0,P54652,Q04637,Q9P258,Q06124 17 +Head morphogenesis 0.6709300559602445 1.0720069161095838 0.283716925733944 1.0 0.7155543532434278 4 Q15042,Q06124 2 +Regulation of mrna export from nucleus 0.6707807341096897 1.071413874866166 0.2839833769068387 1.0 0.7155543532434278 4 Q9ULX6 1 +Epiboly 0.5780176472717912 1.0712196259785691 0.2840706890124731 1.0 0.7155543532434278 6 P61586 1 +Morphogenesis of an epithelial sheet 0.5780176472717912 1.0712196259785691 0.2840706890124731 1.0 0.7155543532434278 6 P61586 1 +Amp salvage 0.6706887065601022 1.0710483933449757 0.2841476707082597 1.0 0.7155543532434278 4 P55263 1 +Purine ribonucleotide salvage 0.6706887065601022 1.0710483933449757 0.2841476707082597 1.0 0.7155543532434278 4 P55263 1 +Purine nucleotide salvage 0.6706887065601022 1.0710483933449757 0.2841476707082597 1.0 0.7155543532434278 4 P55263 1 +Cortical cytoskeleton organization 0.4455583780794285 1.070711588815693 0.2842991303806492 1.0 0.7155662725392423 17 P15311,Q9NQW6,Q00535,Q9Y490,P61586 5 +Regulation of dendrite morphogenesis 0.5359516908468078 1.069278908713564 0.2849440114492245 1.0 0.7166878538273327 8 Q04917,Q14444,O60828,Q9UQB8 4 +Regulation of cell activation 0.3469302758679326 1.0690043468432266 0.2850677107177495 1.0 0.7167086977964472 51 Q9NUQ9,P14174,Q9Y624,P04083,Q9BXW9,P17931,P61586,P43246,O15347,Q96J02,Q06124 11 +Adaptive immune response 0.3837353967889165 1.0662109624927367 0.286328287689459 1.0 0.7184237036571882 32 Q9UQ84,Q9NUQ9,P40763,P04083 4 +Cellular response to lipid 0.3176331357147631 1.0620313625881088 0.2882214476027336 1.0 0.7208597144512028 73 P14174,P04083,Q9H7B4,P61586,Q6PD62 5 +Negative regulation of bmp signaling pathway 0.7873210633946766 1.0590006368130778 0.289599489701591 1.0 0.7208597144512028 3 Q8N0X7,Q9Y2U8 2 +Escrt complex disassembly 0.6674756346525437 1.058293656897831 0.2899215838909055 1.0 0.7208597144512028 4 O43633 1 +Regulation of secretion 0.3171515690638917 1.056573141245866 0.2907064438358056 1.0 0.7208597144512028 70 O43633,P04083,Q06124,P14174,O43768,P30626,Q9Y5X3,O95563,P15311,P55011,Q99816,Q15042,O14745,Q9Y5K6,O75592,O43747,P27695,P20339,Q9UN37,P0DP25,Q00535 21 +Branchiomotor neuron axon guidance 0.7833197056418677 1.0558174314178477 0.2910516327642414 1.0 0.7208597144512028 2 O75592 1 +Hypothalamus cell differentiation 0.7833197056418666 1.0558174314178426 0.2910516327642436 1.0 0.7208597144512028 2 P27695 1 +Endocytosis 0.3116623197121106 1.055439364333672 0.2912244275432896 1.0 0.7208597144512028 89 Q9NVZ3,P02656,P20645,O60749,Q8N6T3,Q15075,Q5JRA6,Q8TEY7,P42566,P09497,Q01518,P62993,Q9Y5X3,Q9Y2T2,P15311,P41440,Q9H4M9,Q99816,P61978,Q9H223,Q9H3U1,P50570,Q9UBF8,Q9Y5K6,P20339,P17931,P0DP25,Q00535 28 +Actomyosin contractile ring organization 0.6090347434708521 1.0551798035394688 0.2913430991935946 1.0 0.7208597144512028 5 Q9NQW6,Q9UN37,Q15149 3 +Mitotic cell cycle phase transition 0.3024937003029569 1.0547044654800817 0.291560508862678 1.0 0.7208597144512028 100 O43633,Q9NYL9,Q07666,Q16763,P04083,O43660,Q9NXR7,Q9Y6G9,Q9UJX4,Q7L2J0,Q04637,Q92547,P31350,P30260,Q15645,O43768,P35241,Q9NQW6,Q9UL46,P54652,P06730,P49321,P14635,P50570,Q6Y7W6,Q9P258,Q93034,Q5TBB1,P27695,Q9UN37,Q7Z7L1,Q9UJX2,P0DP25,Q00535,P11802,O75312,Q06323,P15927 38 +Golgi ribbon formation 0.7859337183841985 1.0538946147456332 0.2919311687300261 1.0 0.7208597144512028 3 O14744 1 +Regulation of systemic arterial blood pressure mediated by a chemical signal 0.7859072909027898 1.0537973751107337 0.2919756955343278 1.0 0.7208597144512028 3 P61586 1 +Regulation of anatomical structure morphogenesis 0.2953509695165758 1.050006405615781 0.2937151676883598 1.0 0.721137226908911 106 P04792,Q9UQB8,Q9Y624,O60828,P78344,P04083,O14786,O15144,P61586,P11233,P23381,P35579,O75340,Q04917,O60271,P35241,Q96HC4,P15311,P55011,P60953,O14745,P35580,Q9P258,Q92766,P50570,Q9NUQ9,Q9H2J4,Q7Z6Z7,Q8N0X7,P40763,Q00535 31 +Leydig cell differentiation 0.7816843826655794 1.04931445348364 0.2940334159963198 1.0 0.721137226908911 2 Q15637 1 +Mrna 5 splice site recognition 0.6075267275653813 1.048852789947028 0.2942458766422522 1.0 0.721137226908911 5 Q8WXF0 1 +Fibroblast proliferation 0.4756165816022149 1.0487830939245917 0.294277960157641 1.0 0.721137226908911 12 P14174,P04179,Q07812,P11802,Q5TBB1 5 +Positive regulation of establishment of protein localization to mitochondrion 0.5311485064840749 1.046695592866533 0.295239997014654 1.0 0.7214881673567989 8 P30419,Q7Z6Z7,O14737,Q9BZL1,P68036,P55786 6 +Protein catabolic process 0.309368776760936 1.0454212127291156 0.295828336851839 1.0 0.7214881673567989 212 O43633,Q92530,Q9UNS2,Q7Z6E9,Q16763,P48506,P48556,Q15386,Q9UJX4,Q13200,Q9UHG3,Q9BUN8,Q9ULT8,P25789,Q9NXV2,Q8N511,Q8TEY7,P25787,P49721,P35241,Q9Y4X5,Q9Y5X3,Q13526,P28072,P28074,Q9UBV2,Q9NRR5,P28070,P54727,Q5VTR2,A0AVT1,Q14258,O95372,P15311,Q99436,Q9UNZ2,Q99816,P63208,P51665,Q9UIQ6,O75592,P20618,Q9Y5K6,Q93034,O43847,Q9H2J4,Q15008,Q9UN37,O43242,Q86UV5,Q96T88,Q04323,Q5VYK3,Q9UJX2,P60900,P46777,P17655,Q5TDH0,Q06323,Q96J02 60 +Positive regulation of translation 0.3406835122449063 1.0452237677897187 0.2959195609275951 1.0 0.7214881673567989 54 P51116,P16989,Q9Y5A9,P60228,Q7Z478,Q567V2,P67809,P78344,P56537,P98179,Q14011,P61586,P46777,Q04637,P08670,Q07666 16 +Organic acid transmembrane transport 0.410903748884712 1.0437125838836605 0.2966183859862665 1.0 0.7214881673567989 21 O95563,O43772,P41440 3 +Response to mineralocorticoid 0.5714347057374285 1.0424423553230449 0.2972066380181539 1.0 0.7214881673567989 6 O95831 1 +Negative regulation of mrna catabolic process 0.4050599884857315 1.0423599271733015 0.2972448380205912 1.0 0.7214881673567989 23 P16989,P35637,Q13148,Q99729,Q9Y2W1,P67809,P98175,Q14011,Q92804 9 +Macrophage migration 0.5712121027208421 1.0414700697081094 0.2976574371607277 1.0 0.7214881673567989 6 P14174 1 +Macrophage chemotaxis 0.5712121027208421 1.0414700697081094 0.2976574371607277 1.0 0.7214881673567989 6 P14174 1 +Positive regulation of epithelial cell proliferation 0.440495849139784 1.0399670843244515 0.2983551933493884 1.0 0.7219929681278251 17 O75340,Q9H2J4,Q13247,P11047,P40763,Q6ZWJ1,O14786,Q92766 8 +Regulation of synaptic transmission gabaergic 0.7792313982011472 1.0395695182456504 0.298539944676663 1.0 0.7219929681278251 2 P27695 1 +Positive regulation of synaptic transmission gabaergic 0.7792313982011472 1.0395695182456504 0.298539944676663 1.0 0.7219929681278251 2 P27695 1 +Negative regulation of myeloid cell differentiation 0.4928667966717494 1.0392146360561565 0.29870492505977 1.0 0.7219929681278251 10 Q6PD62,O15347,Q96T37 3 +Cysteine metabolic process 0.7788225674570753 1.0379464984271003 0.2992949639938398 1.0 0.7221762865650365 2 P48506 1 +Sulfur amino acid catabolic process 0.7788225674570752 1.0379464984270992 0.2992949639938405 1.0 0.7221762865650365 2 Q13867 1 +Phosphatidylinositol phosphate biosynthetic process 0.7815950920245376 1.0379434720613196 0.2992963730304823 1.0 0.7221762865650365 3 Q9UBF8,Q99570 2 +Epithelial cell apoptotic process 0.5290940063937913 1.0370444638678986 0.2997151355296716 1.0 0.7221762865650365 8 Q13247,P20810,O00471 3 +Cellular response to biotic stimulus 0.3884572820140184 1.0367930996069417 0.2998322921287546 1.0 0.7221762865650365 28 Q9NUQ9,P14174,Q9NQ88,P17655,Q6PD62,P61586 6 +Anaphase promoting complex dependent catabolic process 0.5289356257021802 1.0363006925070604 0.3000618831889787 1.0 0.7221762865650365 8 Q16763,Q9UJX2 2 +Regulation of glial cell differentiation 0.5057340458794433 1.035892905287305 0.3002521078647628 1.0 0.7221762865650365 9 Q9UPY3 1 +Regulation of intrinsic apoptotic signaling pathway 0.3496342094612595 1.0350540024861814 0.3006436921818314 1.0 0.7221762865650365 44 P14174,P04179,P04792,P16989 4 +Regulation of plasma membrane organization 0.7780049059689313 1.0347014495568274 0.3008083588864489 1.0 0.7221762865650365 2 P50570 1 +Killing of cells of another organism 0.6041086627310481 1.0345217872000447 0.3008922967949281 1.0 0.7221762865650365 5 P04406,P81605,P05204 3 +Regulation of focal adhesion disassembly 0.7775960752248596 1.033079424310947 0.3015667314217896 1.0 0.7225036273647042 2 Q15555 1 +Cilium movement 0.6604861039670084 1.030589620753482 0.3027333054098866 1.0 0.72442412254904 4 Q86Y56,O14745 2 +Negative regulation of histone modification 0.4472530735540631 1.0303279692876313 0.3028560737687522 1.0 0.72442412254904 16 Q13363,P61964 2 +T cell activation involved in immune response 0.5503364159486699 1.0280322831894946 0.3039346421043098 1.0 0.7244566113802453 7 P40763,P04083 2 +Regulation of neurotransmitter transport 0.4713764799162129 1.0260294398322862 0.3048777074632172 1.0 0.7244566113802453 12 P20339,P0DP25,Q15042,P41440 4 +Negative regulation of phosphorus metabolic process 0.3141528831118463 1.0259314535701771 0.3049238953695048 1.0 0.7244566113802453 67 P04792,Q96KB5,O95373,Q15149,Q9H7B4,Q04637,P23381,P51452,O43768,O60271,Q15257,P31689,Q99816,Q86XL3,Q9NQ88,Q96B36,Q13148,O95684,Q13177,P40763,Q07812,P17931,P0DP25,O00410,P30153 25 +Cellular anion homeostasis 0.7782160218334665 1.0255387186739562 0.3051090659087418 1.0 0.7244566113802453 3 O14745 1 +Negative regulation of protein modification by small protein conjugation or removal 0.3830849180527605 1.0250548102866823 0.3053373264100951 1.0 0.7244566113802453 30 Q04323,P19474,Q00535,P46777,O60678,P61927 6 +Negative regulation of t cell receptor signaling pathway 0.7779141104294429 1.0244312076368554 0.3056316479719316 1.0 0.7244566113802453 3 P15311,P17931 2 +Negative regulation of antigen receptor mediated signaling pathway 0.7779141104294429 1.0244312076368554 0.3056316479719316 1.0 0.7244566113802453 3 P15311,P17931 2 +Cell junction disassembly 0.7779141104294425 1.0244312076368534 0.3056316479719325 1.0 0.7244566113802453 3 Q15555,Q00535 2 +Neuron apoptotic process 0.3495223069500017 1.024405180414896 0.305643936121128 1.0 0.7244566113802453 42 Q96A26,Q99720,Q96B36,P11413,P51858,P04179,Q9NR28,O95831,O75312,Q00535,P61081,P61586,P43246,Q01105 14 +Positive regulation of cellular amide metabolic process 0.3370717409280216 1.0230158718425442 0.3063003414667058 1.0 0.7244566113802453 55 P51116,P16989,Q9Y5A9,P60228,Q7Z478,Q567V2,P67809,P78344,P56537,P98179,Q14011,P61586,P46777,Q04637,P08670,Q07666 16 +Positive regulation of anion transport 0.5669693911351851 1.0229502043632774 0.3063313904267182 1.0 0.7244566113802453 6 P14174,Q15042 2 +Regulation of neuron projection development 0.3487242240268055 1.0213696278861273 0.3070793493966111 1.0 0.7244566113802453 43 Q9NR77,Q9UQB8,Q04917,Q15428,Q9H4M9,O60828,P78344,Q86X55,Q8N0X7,O14786,Q00535,P61586,P08670,Q96G23,Q02790 15 +Regulation of cell shape 0.3988580422801053 1.0209278268905924 0.3072886341603082 1.0 0.7244732035442347 24 Q9UQB8,Q9Y624,P35241,P04083,O14745,P61586 6 +Cellular response to ether 0.7739165985282119 1.0184965184531554 0.3084420545312323 1.0 0.7249535345940278 2 P11802 1 +Synaptic vesicle localization 0.4887706003460514 1.0184500121606814 0.3084641451356078 1.0 0.7249535345940278 10 Q9Y2T2,Q00535,P50570 3 +Dendritic cell migration 0.6571669859613045 1.017455917151769 0.30893659295903 1.0 0.7249535345940278 4 P60953 1 +Pyrimidine ribonucleoside diphosphate metabolic process 0.6571279594902515 1.0173015807113472 0.3090099848744592 1.0 0.7249535345940278 4 Q05682,P11172 2 +Double strand break repair 0.3137181470772675 1.0162399307912713 0.3095151456618199 1.0 0.7253166243622271 74 Q9H1E3,Q15645,Q9Y2K7,Q9H4L7,P35637,P51530,Q9NW82,Q9BXW9,Q9NXR7,Q9NRR5,P46063,P43246,P15927,Q15014 14 +Regulation of cell morphogenesis 0.3426201838405197 1.01553903834019 0.3098489474534909 1.0 0.7255512683582874 50 P35579,P15311,O14745,Q9UQB8,Q9Y624,O60271,P60953,P35241,P04083,O14786,O15144,P50570,P61586,Q9P258,Q92766 15 +Positive regulation of histone deacetylation 0.6564701584512753 1.0147005268365894 0.310248602927976 1.0 0.7255546231617903 4 Q13363 1 +Substrate dependent cell migration cell extension 0.7750511247443757 1.0139357521283998 0.3106134102376092 1.0 0.7259726298741261 3 O14786,Q9Y5K6 2 +Cell substrate adhesion 0.3482201790404546 1.0088302429978184 0.3130560542560512 1.0 0.7289381690776446 41 Q13630,P51452,P50570,Q14247,Q9BTW9,Q15942,P11047,Q9UM22,O14786,O15144,Q00535,P60953,P61586,Q9P258,Q92766,P35609 16 +Protein folding 0.3071867534102233 1.006053943712411 0.3143896218000179 1.0 0.7303744260007637 90 Q9UHV9,P04792,Q99471,P61758,P54652,O75718,O15212,Q9Y3C6,Q02790,Q9BTW9,O75352,P26885,O14737,Q9H3U1,P25685,Q9H2H8,Q9H2J4,Q13451,O00273,Q15813 20 +Plasma membrane organization 0.4348145065571769 1.0055312335870328 0.3146411176123482 1.0 0.7304378842514702 17 O43633,Q9UQB8,P41440 3 +Basement membrane assembly 0.7726049709248527 1.0049785634945652 0.3149071721157108 1.0 0.7307823388783873 3 O60568 1 +Mrna alternative polyadenylation 0.6534601119806814 1.002806344741655 0.3159543069772113 1.0 0.7326061691065996 4 Q8N684,Q69YN4 2 +Response to interleukin 6 0.6534240198015809 1.0026638086446995 0.3160230974397846 1.0 0.7326061691065996 4 Q6PD62 1 +Odontogenesis of dentin containing tooth 0.5445787671273955 1.0021255626925 0.3162829532004498 1.0 0.7326061691065996 7 Q12948,Q13547,Q07812,P35613 4 +Response to food 0.5957818518813691 0.9996733230289782 0.3174686262122312 1.0 0.7337105205723693 5 Q9UMX5,P80303 2 +Neural nucleus development 0.448785602380624 0.999386630051316 0.3176074340395489 1.0 0.73375824605119 15 P61586,P80723,P0DP25 3 +Regulation of endocytosis 0.370005284443661 0.9971189826446988 0.3187067599939313 1.0 0.7347500422897534 34 P02656,P41440,Q99816,P20339,Q8N6T3,Q9H223,P0DP25,Q9H3U1,Q9Y5K6 9 +Regulation of t cell proliferation 0.4605152203579651 0.9967930881114184 0.3188649539405612 1.0 0.7347500422897534 13 P04083 1 +Mitotic cytokinetic process 0.4974854934839694 0.9955107597475238 0.319487913782674 1.0 0.7359124423554918 9 P61586 1 +Centromeric sister chromatid cohesion 0.5605730604169589 0.995075052404626 0.3196997631411618 1.0 0.735959908115507 6 P41227,O43683,P30153 3 +Clathrin coat assembly 0.5429466468998585 0.9947907396016112 0.3198380510716925 1.0 0.735959908115507 7 P42566,P09497,Q13492,P09496,P53680 5 +Myelin assembly 0.6512374488229878 0.9940322930751544 0.3202071459790239 1.0 0.735959908115507 4 Q9UPY3 1 +Protein k48 linked deubiquitination 0.4968446005414937 0.99237818247922 0.3210130777300102 1.0 0.7369362403994135 9 Q9H8M7,Q8TEY7,P45974,Q04323 4 +Regulation of lipid kinase activity 0.5939418747441678 0.9919863642253748 0.3212041771678635 1.0 0.7369362403994135 5 A4D1P6,P06400,P60953,Q99570 4 +Response to osmotic stress 0.4474826247027011 0.9919175524968264 0.3212377460162983 1.0 0.7369362403994135 15 P16989,P55011,Q9Y376,Q07812,P35237 5 +Positive regulation of chromosome condensation 0.593123209169055 0.9885678906009489 0.3228746026708726 1.0 0.7387808705180984 5 Q9NTJ3,O95347,Q15021,Q9BPX3 4 +Neuron development 0.2883680247253933 0.9858412637754222 0.3242110133882319 1.0 0.7407470173439735 131 Q9UQB8,Q15428,O60828,P78344,P04179,P00374,P16949,O14786,Q99873,P61586,P08670,P33176,Q06124,Q8TEY7,Q8WX93,Q15555,Q04917,O60271,Q14247,Q99707,Q9BUP0,Q9BW83,Q86X55,Q9Y296,Q9UPY3,Q9NR77,A0AVT1,O95372,Q02790,P55145,P18085,P61964,P41440,Q9H4M9,Q9BTW9,P35613,Q9UBB4,O14745,P50570,O60678,O75592,Q96G23,Q99829,P11047,Q8N0X7,Q00535,O75312 47 +Positive regulation of cell activation 0.3711669833344929 0.9853178937757864 0.3244679459806541 1.0 0.7409118198095216 33 Q9NUQ9,P14174,P04083,P61586,P43246 5 +Long chain fatty acid biosynthetic process 0.7668711656441725 0.9840216451298164 0.3251048704542483 1.0 0.7415815268595437 3 Q96PU8,P28161 2 +Regulation of mrna polyadenylation 0.4683717086377877 0.9837356978685036 0.3252454828895417 1.0 0.7415815268595437 11 Q69YN4,Q8N684,Q5VTR2,Q6PD62,O00267 5 +Nucleoside monophosphate metabolic process 0.3794539510034789 0.981920056117813 0.3261392342271505 1.0 0.742895723337056 29 P30085,Q9BZX2,P30520,P07741,Q05682,P34896,P00491,Q9UDY2,P11172,O15067,P55263,P00568 12 +Positive regulation of interleukin 1 production 0.5172883843419047 0.9817084795286514 0.3262434867515937 1.0 0.742895723337056 8 P04792,Q99584 2 +Peptidyl lysine modification 0.3107414930107916 0.9809235615820896 0.3266304374404565 1.0 0.7429945115403791 74 Q13363,Q96AY3,P61964,Q9H7B4,Q6PD62,Q86UY6,O15047,Q01105,Q15014 9 +Body morphogenesis 0.5568373351359494 0.9788233928414766 0.3276672491272476 1.0 0.7445348031760731 6 Q06124,Q15042,O95470 3 +Membrane disassembly 0.6472905082533036 0.978471059443068 0.3278413981407964 1.0 0.7446580404002727 4 Q9ULX6 1 +Negative regulation of kinase activity 0.3617792329414249 0.9762130322792644 0.3289589063530109 1.0 0.7467182431735622 36 Q96B36,P04792,O95684,Q9H7B4,P23381 5 +Peptidyl arginine modification 0.5555592353329702 0.9732685308332882 0.3304198584555422 1.0 0.7494183057008463 6 O60678,Q99873,O14744 3 +Carboxylic acid transport 0.391993177069081 0.972286936805934 0.3309078207777429 1.0 0.7498961509330533 24 P14174,P41440,P04083,O95563,Q15042,O14745 6 +Negative regulation of jnk cascade 0.7635991820040927 0.972088326475664 0.3310066090620094 1.0 0.7498961509330533 3 P51452,Q96J02 2 +Positive regulation of leukocyte migration 0.4609780994531423 0.97038005311104 0.3318570875565387 1.0 0.75079925061153 12 P61586 1 +Peptidyl lysine dimethylation 0.5887429152462589 0.970295988277346 0.3318989763796978 1.0 0.75079925061153 5 O15047,Q9H9B1 2 +Negative regulation of establishment of protein localization to mitochondrion 0.7616516762060537 0.9701014371719554 0.3319959327180775 1.0 0.75079925061153 2 P31689 1 +Positive regulation of small molecule metabolic process 0.4791393835972231 0.9697494641621766 0.3321713882186945 1.0 0.7509225776622108 10 P04083 1 +Regulation of actin filament organization 0.3377387102601453 0.9678273157395748 0.3331306192699177 1.0 0.7519285258677152 50 Q9NYL9,Q9NUQ9,Q9UQB8,Q9Y624,P62993,Q14247,Q9Y281,P35241,Q14019,P60953,P16949,O15143,O14786,O15144,P59998,P61586,P35609,Q92747 18 +Arf protein signal transduction 0.7622570458076505 0.967199051607547 0.3334445362123772 1.0 0.7519285258677152 3 Q8N6T3 1 +Negative regulation of multicellular organismal process 0.3082679057566823 0.9628287197524242 0.3356334854718068 1.0 0.7547586584839747 80 P02656,P16989,Q13247,P04083,Q9UIQ6,P61586,Q96G23,Q9UPY3 8 +Cell differentiation involved in kidney development 0.553073051355368 0.9624713054583576 0.3358129103689569 1.0 0.7547586584839747 6 P80723 1 +Epithelial cell differentiation involved in kidney development 0.553073051355368 0.9624713054583576 0.3358129103689569 1.0 0.7547586584839747 6 P80723 1 +Regulation of protein monoubiquitination 0.7587898609975523 0.9588608151721846 0.3376288672613228 1.0 0.7563763584750414 2 O75340 1 +Positive regulation of protein monoubiquitination 0.7587898609975523 0.9588608151721846 0.3376288672613228 1.0 0.7563763584750414 2 O75340 1 +Small molecule biosynthetic process 0.2796918678709419 0.9560411951229616 0.3390514222571923 1.0 0.7581956543814059 117 P02656,P14174,P61964,P34896,Q15392,Q99707,P09960,O60678,P04083,P22570,O60568,P56937,P55263,P28161,Q14353,P36871 16 +Embryo implantation 0.5116332404468902 0.9552893425037716 0.339431395528631 1.0 0.7587721260737216 8 Q02790,Q13263,P35613 3 +Negative regulation of neuron death 0.3673762187196148 0.9547451258450144 0.3397066035147118 1.0 0.759099731548558 33 P51858,Q9UMX5,P04179,O75312,Q00535,P61586,Q9NQ88,Q04637,P43246,Q01105 10 +Integrin mediated signaling pathway 0.446875708269211 0.9533414541050492 0.3404170943824856 1.0 0.7595471075433191 14 P35579,Q15942,O14786,Q9Y490,Q9P258,Q06124 6 +Regulation of intracellular signal transduction 0.3039694134558406 0.9533040133638492 0.3404360586391348 1.0 0.7595471075433191 209 P02656,Q92734,Q9H7B2,P04792,Q9UNS2,Q9Y624,P04179,P16949,Q8N6T3,Q9Y6G9,P19474,Q99873,Q9UQ13,P61586,Q06124,O75340,P14174,Q15555,O60271,P62993,P29692,P35241,P56537,Q13526,Q13325,O43324,P61927,Q14258,P15311,Q9Y2U8,P16989,P41440,P52565,P15927,Q02952,O14745,Q9Y5K6,Q5TBB1,Q96B36,Q9NUQ9,Q99829,Q9UMX5,P0DP25,P46777,O14744,Q96J02,Q99584 47 +Regulation of synaptic vesicle recycling 0.5845322028784974 0.9527632267947804 0.3407100500599092 1.0 0.7595471075433191 5 P0DP25 1 +Negative regulation of dna templated transcription elongation 0.5505553044929061 0.9515485663681544 0.3413259768125232 1.0 0.7599979619956145 6 Q8WX92,O00267,Q9H3P2,O14776 4 +Gliogenesis 0.3410476266078824 0.9500598310244454 0.3420818522537239 1.0 0.7606853214510779 43 Q9UI10,P11047,P04083,Q9NR50,P40763,O14744,P61586,Q9UPY3,Q96G23,Q06124 10 +Endosome to lysosome transport 0.4751400655003209 0.9495866457599572 0.3423223266313258 1.0 0.7606853214510779 10 Q96AX1,P20645 2 +Establishment or maintenance of monopolar cell polarity 0.4878337478555303 0.9484250550059382 0.342913109334978 1.0 0.7610759145711985 9 P15311,P60953,P26038,O14745,P61586 5 +Positive regulation of gliogenesis 0.532134403803122 0.9463166988966476 0.3439870786101582 1.0 0.7626418272649349 7 Q9UPY3 1 +Salivary gland development 0.7555192150449747 0.9460401881072787 0.3441280887307394 1.0 0.762682166673052 2 O14786 1 +Adherens junction assembly 0.6388977289403452 0.9454719099354292 0.3444180050803682 1.0 0.7627544823795275 4 Q13177,Q9BTW9 2 +Positive regulation of cilium assembly 0.5826684333777258 0.945013418768378 0.3446520253714902 1.0 0.7627544823795275 5 Q15555 1 +Deoxyribonucleotide biosynthetic process 0.531630288534772 0.9440620976626914 0.3451379164648536 1.0 0.7635576990547704 7 P34896 1 +Negative regulation of vascular associated smooth muscle cell proliferation 0.6382851836251218 0.943068645997258 0.3456457919184319 1.0 0.764098379004432 4 P61586 1 +Polarized epithelial cell differentiation 0.5088264567161723 0.9422019027778769 0.3460892799322761 1.0 0.764098379004432 8 P15311,P60953,P26038,O14745,P61586 5 +Cytokinetic process 0.4384177960133708 0.9400891888753043 0.3471718138223931 1.0 0.7656026149989565 15 P35579,O43633,Q9UN37,Q9NQW6,Q15149,P61586,P50995 7 +De novo pyrimidine nucleobase biosynthetic process 0.5813554385336016 0.9395579162841796 0.3474443713588551 1.0 0.7658832880504025 5 Q05682,P11172 2 +Smooth muscle cell migration 0.5082165469612194 0.9393603759656336 0.3475457497143372 1.0 0.7658832880504025 8 P61586,P31949,O14786,P27695 4 +Positive regulation of cysteine type endopeptidase activity 0.3927672848025659 0.9379838796101092 0.348252694547349 1.0 0.7668968911840557 22 O75340,Q96A26,Q92688,O95831,O14737,P61586 6 +Dna methylation dependent heterochromatin assembly 0.4855303963956928 0.9372197636663264 0.3486455255862541 1.0 0.7674897957783192 9 O95983,Q13263,Q99549 3 +Cell cycle phase transition 0.2828070437078501 0.9355177576736324 0.3495215362241706 1.0 0.7687896602933119 126 Q06323,O43633,Q9NYL9,Q07666,Q16763,P51530,P04083,O43660,Q9NXR7,Q9Y6G9,Q9UJX4,Q08J23,Q7L2J0,Q04637,Q92547,P43246,Q06124,P31350,P30260,Q15645,O43768,P35241,Q9NQW6,Q9UL46,P54652,P06730,P49321,P14635,Q07864,Q92900,P50570,Q6Y7W6,Q9P258,Q93034,Q5TBB1,P27695,Q9UN37,Q9ULX6,Q7Z7L1,Q9BXW9,Q9UJX2,P0DP25,Q00535,P11802,O75312,Q8N6R0,P15927 47 +Platelet derived growth factor receptor signaling pathway 0.546608741771293 0.9344521554196898 0.3500707048921034 1.0 0.7688766720650329 6 O14786,Q06124,O14745 3 +Regulation of protein folding 0.6358324412942813 0.9334530436812736 0.3505861039836504 1.0 0.7688766720650329 4 Q9H2J4 1 +Muscle structure development 0.3062400823429243 0.9309794063850128 0.351864216925402 1.0 0.7706071504047771 77 Q9NYL9,Q96PU8,P80723,P67809,P04179,Q9H7B4,P61586,P35579,O60271,P30626,Q96HC4,O00151,P35609,Q15014,P16989,P41440,Q9Y281,Q9H4M9,Q9H3U1,Q14331,Q7Z4V5,Q9Y5Q8,P11413,Q00535,P17655 25 +Urogenital system development 0.3562824399228024 0.9299361247903012 0.3524041575712382 1.0 0.7706071504047771 36 P80723,Q9BW83,P04083,P61586,Q02790 5 +Response to platelet derived growth factor 0.578512435601465 0.92775730430983 0.3535334758719914 1.0 0.7716846696538021 5 Q96A49,P35241 2 +Basement membrane organization 0.6339167320457345 0.9259513718000294 0.3544712522424034 1.0 0.7729165998684427 4 O60568 1 +Negative regulation of potassium ion transport 0.7498056648327658 0.9220089141633112 0.3565239259579398 1.0 0.774708177579455 3 Q9Y376 1 +Negative regulation of potassium ion transmembrane transport 0.7498056648327658 0.9220089141633112 0.3565239259579398 1.0 0.774708177579455 3 Q9Y376 1 +Cellular response to hormone stimulus 0.2954151692467807 0.9205641192521504 0.3572780424627606 1.0 0.774708177579455 97 Q9UQB8,P48506,P04083,P43490,Q9H7B4,P61586,Q92600,Q06124,O60343,P07741,P62993,P35241,Q86X55,Q9Y5X3,Q02790,Q9H1E3,O95831,Q96A49,P27695,P40763,P11802 21 +Regulation of cell communication by electrical coupling 0.7493842822342021 0.9204852472509218 0.357319238913351 1.0 0.774708177579455 3 P0DP25 1 +Negative regulation of cell substrate adhesion 0.5431715516838609 0.9195889152790788 0.3577876214628182 1.0 0.774708177579455 6 P61586,Q9P258 2 +Cellular response to oxygen levels 0.3711773030045425 0.918733423604582 0.3582350229515034 1.0 0.7754058879500998 29 Q15904,Q8N511,P55786,O95831 4 +Negative regulation of cell population proliferation 0.3052130772936896 0.9174561221499352 0.3589036754718222 1.0 0.7765825173101101 70 Q13363,Q99627,P17096,Q99816,Q15392,P04179,Q15637,P40763,Q96G23,O14745,P61586,Q9NR77,O43324,P23381,Q96J02,Q9UPY3 16 +Response to interleukin 1 0.4457067756262894 0.9160830213115652 0.3596233522974077 1.0 0.7770197085599233 13 P04083 1 +Hyperosmotic response 0.525001832710653 0.9144687815027468 0.3604705745501086 1.0 0.7770197085599233 7 P16989,P55011 2 +Metanephros development 0.5419810154116247 0.9144468567132136 0.3604820902352881 1.0 0.7770197085599233 6 P80723 1 +Cell cycle 0.245109848122895 0.9132787576797076 0.3610959515136098 1.0 0.7775332381759769 395 Q9UQ84,P78344,P04083,Q99570,P19474,O95373,P61586,P11233,P50995,Q13363,P35579,P51452,P31350,P30260,Q9H4L7,Q15392,Q9BY42,Q9UL46,Q15257,Q15014,P06730,P14635,P61964,P52701,P46379,P39748,Q07864,Q86XL3,Q6ZWJ1,P33993,P78362,P60953,P35580,Q6Y7W6,Q8N3U4,Q96CT7,Q15691,Q8NFH4,Q9UJX2,P08243,O00410,P30153,O43633,Q15018,P41227,Q9P287,Q92905,Q96KB5,Q9NXR7,Q9Y3A5,Q15149,Q7L2J0,P68036,Q92547,O43264,O43683,P27694,P33991,P52758,Q8WUM4,Q15021,Q13526,Q9Y5K5,Q9GZZ1,Q8TBC4,Q9UNM6,Q14974,P06493,P17612,Q9UNZ2,P23921,O75935,Q13112,P68371,O14745,Q6P1J9,Q7Z460,Q6DKK2,Q9Y5A9,Q9ULX6,Q9BXW9,P40763,P0DP25,O14744,P15927,Q16763,Q14203,P51530,O43660,Q9Y6G9,Q9UJX4,Q04637,P43246,Q06124,Q8TEY7,Q86WB0,Q15645,Q15555,Q9NQW6,P54652,P49321,P52732,Q99816,Q9BUF5,Q9NYV4,Q9P258,Q9Y5K6,Q93034,Q5TBB1,P27695,Q13148,O15355,Q15813,Q00535,P11802,O75312,Q9NVI1,Q8N6R0,Q9NYL9,P16949,Q08J23,Q12824,O43768,P35241,Q9NUQ3,Q5VTR2,P15311,P43487,Q9BTW9,Q92900,Q9NTJ3,Q9Y266,P50570,P09884,Q92733,Q9NVX2,Q9UN37,Q96T88,Q7Z7L1,Q07812,Q15418,Q06323,Q07666 143 +Ventral spinal cord development 0.7470702868727378 0.9121251641783648 0.3617028328842848 1.0 0.7783002745015277 3 Q6Y7W6 1 +Response to insulin 0.3316021230481453 0.9081210809444014 0.363814253782871 1.0 0.7799618231125711 50 Q9H1E3,O60343,Q9UQB8,P62993,Q13247,P48506,P56537,Q9Y5X3,P43490,Q96A49,P11802,Q06124 12 +Histone methylation 0.3359665629164362 0.9074054560202304 0.3641924252647746 1.0 0.7799618231125711 44 P61964,Q9H9B1,Q86X55,Q9H3P2,Q99873,Q12824,O14744,Q9H7B4,Q6PD62,O15047 10 +Negative regulation of execution phase of apoptosis 0.7452984464431771 0.9061653049002144 0.3648483639356215 1.0 0.7799618231125711 2 O00273 1 +Myeloid leukocyte activation 0.4382828345988165 0.9055518225480148 0.3651731186829234 1.0 0.7799618231125711 14 P14174,P04083 2 +Retrograde axonal transport 0.5730659025787972 0.9051990209182644 0.3653599604816862 1.0 0.7799618231125711 5 P33176,Q03001,Q14204,P27695 4 +Microtubule polymerization 0.3878906429802577 0.9047702512093768 0.3655871148938185 1.0 0.7799618231125711 22 Q14203,Q9BTW9,P16949,Q13526,Q15691,Q02790 6 +Glycosyl compound biosynthetic process 0.5393768190611918 0.9032105215172772 0.3664141748000789 1.0 0.7803264833705383 6 Q13126,P55263 2 +Nucleobase containing small molecule biosynthetic process 0.5393768190611918 0.9032105215172772 0.3664141748000789 1.0 0.7803264833705383 6 Q13126,P55263 2 +Positive regulation of endothelial cell proliferation 0.5214885547527535 0.8988254227338179 0.3687456564266163 1.0 0.7823944213795642 7 O75340,Q9H2J4 2 +Cellular component morphogenesis 0.2900877824183697 0.8983048092847545 0.3690230692787026 1.0 0.7823944213795642 101 Q9NYL9,Q9UQB8,Q16555,O60828,P78344,O60749,P16949,O14786,Q13596,Q15149,P61586,P33176,Q06124,Q8TEY7,Q8WX93,P31150,Q04917,O60271,Q14247,Q96HC4,Q9UPY3,Q9NR77,P35609,O95372,Q9Y281,P41440,P35613,P60953,P50570,O60678,O75592,Q92766,Q99829,P11047,Q13177,Q8N0X7,P18206,Q07812,Q00535,Q8IYB8 40 +Vesicle mediated transport 0.2970235109167595 0.8980174261867286 0.369176259145572 1.0 0.7824520714314002 249 Q9NT62,Q9NVZ3,P02656,O43633,Q92734,O60664,Q14203,P20645,P04083,Q15904,Q8N6T3,O60749,Q5JRA6,Q15075,O75340,Q8TEY7,P42566,P09497,Q8TAG9,O60343,Q99439,Q01518,Q8TBQ9,P40616,P62993,O60271,P35241,Q8IWJ2,Q9Y5X3,Q9Y296,Q9Y2T2,P54652,P35609,P15311,P35606,P18085,P41440,Q9H4M9,Q99816,Q9H223,Q15042,Q9H3U1,Q9BXS5,Q9UBF8,P83436,Q9Y5K6,Q99829,P27695,P20339,Q9BVK6,O00471,P17931,P0DP25,Q00535,Q96AX1,Q15436,Q99584 57 +Cell killing 0.4168622820300667 0.8973701061691445 0.3695214586021076 1.0 0.7829164987782627 17 Q9NUQ9,P05204,P04406,P81605,O43747 5 +Superoxide metabolic process 0.5704680240866489 0.8944633541498578 0.3710740284081504 1.0 0.7838597371488134 5 P04179 1 +Ribonucleoside triphosphate metabolic process 0.3573982120034225 0.8941957132734816 0.3712171854264154 1.0 0.7838597371488134 34 P61586,Q9BZX2,O00178,Q9NRF8 4 +Regulation of receptor mediated endocytosis 0.4156422305915607 0.890065085532409 0.3734309390972796 1.0 0.7860555251607215 17 P02656 1 +Glial cell proliferation 0.6245160175559188 0.8892564632051708 0.3738652638202722 1.0 0.7860555251607215 4 Q9UPY3 1 +Sarcomere organization 0.5191977337100071 0.8886422253897851 0.3741953901340764 1.0 0.7862543412207622 7 Q15149,P35609,Q9Y281 3 +Positive regulation of atp dependent activity 0.3987687566382354 0.8880705519960835 0.374502801850846 1.0 0.7864938787601468 19 Q96T88,P25685,P50570,P54652,P43246,Q8WXX5,Q8NFQ8 7 +Antigen receptor mediated signaling pathway 0.4149188753109634 0.8857372749582686 0.3757591171319361 1.0 0.7883324720909876 17 P15311,Q9UI10,Q9NR50,P17931,Q07812,Q07666 6 +Calcium ion transport into cytosol 0.4494816643907905 0.8853323275921335 0.3759774192142422 1.0 0.7885240706924836 11 P28161,P30626,P0DP25,P27695 4 +Regulation of mitotic cell cycle phase transition 0.3025490638191666 0.8843686732640076 0.3764972280312784 1.0 0.788959734490212 74 Q9NYL9,O43660,P04083,Q9Y6G9,Q9NXR7,Q9UJX4,Q7L2J0,Q04637,Q92547,P31350,P30260,Q15645,P35241,Q9NQW6,Q9UL46,P54652,Q6Y7W6,Q9P258,Q5TBB1,P27695,Q9UN37,Q7Z7L1,Q9UJX2,P11802,Q06323,P15927 26 +Face development 0.5182065868288073 0.8842407059859666 0.3765662887325263 1.0 0.788959734490212 7 Q15042,Q06124 2 +Positive regulation of dendritic spine development 0.5346966448204097 0.883058725186621 0.3772045432782698 1.0 0.7894978812800996 6 Q14444,Q9UQB8,P78344 3 +Regulation of microtubule polymerization 0.4279882163627155 0.8808105584808871 0.3784203639891546 1.0 0.790976257277903 15 Q15691,Q02790,Q14203,P16949 4 +Establishment or maintenance of cell polarity 0.3329373636762337 0.8793100432127872 0.3792331918873541 1.0 0.7914031676047518 44 P35579,P15311,Q9NUQ9,P18085,O14745,Q01518,Q9UNZ2,P26038,Q14203,Q8WUM4,Q13112,P60953,P61586,O43264,O00151,Q7Z460,Q9Y696,P61026 18 +Regulation of cellular component movement 0.2797611293063801 0.8792572529815311 0.3792618078569632 1.0 0.7914031676047518 109 P04792,P04179,P04083,P16949,P61586,Q5JRA6,O75340,Q13630,P14174,Q15555,Q99439,O60271,P30626,P31949,P35241,Q13526,Q02952,O14745,Q9P258,Q92766,O75592,Q96G23,Q9NUQ9,P27695,O95684,P40763,P17931,Q00535 28 +Protein acetylation 0.3339599725015548 0.8784896851493592 0.3796780329532194 1.0 0.7918853310611063 41 Q13363,Q5VZE5,P61964,P41227,Q86UY6,Q15014 6 +Negative regulation of cytokine production 0.3883071760287375 0.8777148288998565 0.3800984950691188 1.0 0.7922505608455956 20 Q9UPY3,P04083 2 +Negative regulation of response to biotic stimulus 0.3967040865231681 0.8749411753283912 0.3816059136206231 1.0 0.7939114451691744 19 P19474,Q96J02 2 +Positive regulation of potassium ion transport 0.5326508238245029 0.8742677159342511 0.3819724764282168 1.0 0.7939114451691744 6 P35609,P50570 2 +Mrna catabolic process 0.2974427971740622 0.8742208918616015 0.381997970719081 1.0 0.7939114451691744 89 Q92945,Q99729,P60228,Q9Y2W1,P67809,P62312,P98175,Q14011,Q9Y2L1,P08670,Q9Y2V2,O00178,P51116,P16989,Q92900,Q9C0B1,Q6Y7W6,Q9Y5A9,P27695,P35637,Q6P6C2,Q13148,Q8NC51,Q8IYB8,Q13310,Q92804,Q969T7 27 +Anion transport 0.3297480048917466 0.8733652601368879 0.3824640200671851 1.0 0.7946141065965941 48 P14174,P41440,P04083,O00400,O95563,Q6N075,Q15042,Q9UHG3,O14745 9 +Regulation of lymphocyte migration 0.5651625241038385 0.872590747212573 0.3828861856827443 1.0 0.795225154879546 5 P61586 1 +Regulation of cell population proliferation 0.2938772823788296 0.8706940970491762 0.3839212024362548 1.0 0.7958095820004821 169 P04179,P04083,Q15637,P43490,P98175,Q99873,Q12824,P61586,P23381,Q13363,O75340,P14174,Q99439,P31949,Q15392,Q86X55,Q9UPY3,Q9NR77,O43324,Q99816,Q13247,P07384,O14737,Q9C0B1,O14745,Q92766,Q96G23,Q5TBB1,Q99627,Q9H2J4,P17096,O95684,P11047,P40763,P17931,P11802,Q96J02,Q99584 38 +Negative regulation of phosphorylation 0.3206914276016996 0.8706390075201486 0.3839512907902671 1.0 0.7958095820004821 56 P04792,Q96KB5,O95373,Q15149,Q9H7B4,Q04637,P23381,P51452,O60271,P10644,Q13610,P31689,Q99816,Q86XL3,Q9NQ88,Q96B36,Q13148,O95684,Q13177,P40763,Q07812,P0DP25,O00410,P30153 24 +Pigment accumulation 0.7353466161059217 0.8699632726826901 0.3843204755978859 1.0 0.7958095820004821 3 Q9BXS5 1 +Pigment granule maturation 0.7353466161059217 0.8699632726826901 0.3843204755978859 1.0 0.7958095820004821 3 Q9BXS5 1 +Negative regulation of ion transmembrane transport 0.4370561398521889 0.8692707839328391 0.3846990390677678 1.0 0.7958095820004821 13 Q9Y376,P30626,P0DP25,O14745,P28161 5 +Proteolysis 0.274773910107121 0.8684979479807908 0.3851217951707975 1.0 0.7964057102932575 307 P81605,P19474,Q9UHG3,P61586,Q9NXV2,Q15392,P28072,P28074,Q9NRR5,P28070,Q99436,Q9UBW8,P51665,O95831,Q9UIQ6,P35237,Q9HB40,Q9H2J4,Q04323,Q9UJX2,P55786,Q96J02,O43633,P61009,Q9NXR7,Q9BUN8,O75340,P49721,Q9Y4X5,Q8TBC4,Q96A26,Q9UNZ2,Q9H8M7,P09960,Q92688,Q86TI2,P20618,Q99627,Q99829,O43242,P40763,Q9UJ14,Q16763,P48556,Q9UJX4,P25789,Q8TEY7,P25787,P20810,P54727,A0AVT1,Q99816,P07384,O14737,Q9Y5K6,Q93034,Q13867,Q9NR28,Q00535,P46777,P17655,Q92530,Q9UNS2,Q7Z6E9,P48506,Q15386,Q13200,Q9ULT8,Q9H4L4,Q9UBV2,Q5VTR2,Q14258,P63208,O43847,Q9NVX2,Q9UN37,Q86UV5,Q96T88,P04406,Q5VYK3,P60900,Q07812,Q15008,Q15418,Q5TDH0,Q06323 86 +Regulation of mrna binding 0.5311825611822171 0.8679655307636781 0.3854132027469279 1.0 0.7967430056785694 6 P60228,Q04637 2 +Negative regulation of erk1 and erk2 cascade 0.4415491218732805 0.8672090321324213 0.3858274883174526 1.0 0.7970219282642163 12 P15311,Q96S59,P56537,Q13526,O14745 5 +Neurogenesis 0.2979232843729528 0.8670531584787785 0.3859128840599104 1.0 0.7970219282642163 194 Q8WUJ1,Q9UQB8,Q15428,O60828,P04179,P04083,P00374,P16949,Q99873,P61586,Q04637,Q06124,Q8TEY7,Q8WX93,Q15555,O60271,P26196,Q99707,Q9BW83,Q86X55,Q13526,Q9Y296,Q9UPY3,Q9NR77,A0AVT1,O95372,Q02790,P55145,P18085,P61964,P41440,Q9H4M9,Q9BTW9,P35613,Q9UBB4,O14745,Q6Y7W6,O60678,O75592,Q96G23,Q99829,Q9Y5A9,P27695,P11047,Q9UI10,Q9NR50,Q8N0X7,P40763,Q00535,O14744,O75312 51 +Positive regulation of protein modification process 0.2855606827683498 0.8667819253362603 0.3860615072816042 1.0 0.7970219282642163 143 Q9UBT2,Q16763,Q9H3P2,Q12824,Q9H7B4,Q9BUN8,P61586,Q04637,Q92600,Q06124,Q13363,O75340,P14174,Q9Y376,Q13526,Q15257,Q6PD62,P54652,Q5VTR2,P61964,P51116,P41440,Q9H223,Q96A49,Q15042,O75592,Q99627,Q9ULX6,P49354,P0DP25,Q00535,Q9NVI1 32 +Negative regulation of mrna 3 end processing 0.5636814227729385 0.8664978956236735 0.3862171798893672 1.0 0.7970783273888237 5 Q5VTR2,Q6PD62 2 +Positive regulation of non motile cilium assembly 0.6185587982358665 0.8661126977721598 0.3864283625215761 1.0 0.797249213042853 4 Q15555 1 +Axoneme assembly 0.7346688470973058 0.8650303605908434 0.3870221251581327 1.0 0.7979440229853931 2 Q15555 1 +Cellular response to x ray 0.5630544701688538 0.8639205841725772 0.3876315182693277 1.0 0.7981435605258063 5 Q9H1E3,P50570 2 +Regulation of homotypic cell cell adhesion 0.73347080795683 0.8632492362864367 0.3880004481703398 1.0 0.7984380760755109 3 Q9Y624 1 +Lymphocyte activation involved in immune response 0.3732491097895914 0.8613947712508242 0.3890206548720329 1.0 0.7991223186663423 25 Q9UQ84 1 +Circadian regulation of gene expression 0.4182692494382807 0.8608408331892508 0.3893257121597906 1.0 0.7991223186663423 16 P43490,O75592,Q9Y2K7 3 +Positive regulation of chromosome separation 0.5128983251713275 0.8607147069643489 0.3893951910280759 1.0 0.7991223186663423 7 Q9UJX2,Q9UJX4 2 +Positive regulation of exosomal secretion 0.5290565434384007 0.8588508277550899 0.3904228211701777 1.0 0.8001735047745225 6 Q99816,O43633,Q9UN37 3 +Double strand break repair via break induced replication 0.5120187468073485 0.856824461476347 0.3915419046945341 1.0 0.8014721805412006 7 Q9BRT9,P33993,P33991 3 +Endosomal vesicle fusion 0.7322158626328739 0.855590586165681 0.39222427885038 1.0 0.802276934012141 2 Q9UN37 1 +Glomerular epithelium development 0.560690382798231 0.8542120360503783 0.392987515457992 1.0 0.8033089107946447 5 P80723 1 +Glomerulus development 0.560690382798231 0.8542120360503783 0.392987515457992 1.0 0.8033089107946447 5 P80723 1 +Organic anion transport 0.356832303262555 0.8525788644989714 0.3938928874138852 1.0 0.8041284642288448 32 P14174,P41440,P04083,O00400,O95563,Q15042,O14745 7 +Regulation of cell size 0.3624524354137536 0.8525544939769673 0.3939064071149993 1.0 0.8041284642288448 29 P15311,P54105,Q96B36,P31150,P55011,Q16555,Q14247,P35241,P78344,Q8N0X7,O14786,Q00535,P50570,P61586,O14745 15 +Negative regulation of protein kinase b signaling 0.614947230403792 0.8521271285426326 0.3941435364433023 1.0 0.8043481305661871 4 O75340 1 +5 phosphoribose 1 diphosphate metabolic process 0.6145662847790437 0.8506540297126178 0.3949615665751729 1.0 0.8054637737659978 4 P06737,P11908,O60256 3 +Neurotrophin signaling pathway 0.5596006385746988 0.8497421739453438 0.3954684454448514 1.0 0.8054637737659978 5 Q96B36,Q06124 2 +Neurotrophin trk receptor signaling pathway 0.5596006385746988 0.8497421739453438 0.3954684454448514 1.0 0.8054637737659978 5 Q96B36,Q06124 2 +Response to fibroblast growth factor 0.5102598710550947 0.8490523714950564 0.3958521512133619 1.0 0.8058549200316009 7 P48506,Q06124 2 +Vesicle targeting rough er to cis golgi 0.4886357361995312 0.8486631123577996 0.3960687776103779 1.0 0.805893548152178 8 Q92734 1 +Regulation of cell morphogenesis involved in differentiation 0.3818100396299219 0.848334943341312 0.3962514623834094 1.0 0.806001173075982 21 Q9UQB8,O14786,O15144,P50570,Q9P258,Q92766 6 +Lymphocyte chemotaxis 0.7297628781684422 0.8461717968729942 0.397456912834955 1.0 0.8069633572063706 2 P55011 1 +T cell chemotaxis 0.7297628781684422 0.8461717968729942 0.397456912834955 1.0 0.8069633572063706 2 P55011 1 +Regulation of mononuclear cell migration 0.4327325836077429 0.8459894121283776 0.397558650835792 1.0 0.8069633572063706 13 P61586 1 +Positive regulation of transporter activity 0.4003239727410316 0.8455190863064438 0.3978210807918549 1.0 0.8070790302899116 18 P27695,P0DP25,Q00535,P54652,P28161,P35609 6 +Cellular nitrogen compound catabolic process 0.2813254877252292 0.8449750262473464 0.398124782803031 1.0 0.8071677770835202 136 Q9H773,Q92945,Q99729,P60228,P51530,Q9Y2W1,P67809,P62312,P98175,Q08J23,Q14011,Q9Y2L1,P08670,P25325,Q9H814,Q9Y2V2,Q9UPY3,O00178,P51116,P16989,Q92900,O95831,Q9C0B1,Q6Y7W6,Q13126,Q5TBB1,Q9Y5A9,P27695,P35637,Q6P6C2,O00273,Q13148,Q8NC51,Q8IYB8,Q9NRN7,Q13310,Q07812,O75312,Q92804,Q969T7 40 +Primary mirna processing 0.6121905510958028 0.8414764373412297 0.4000810798021343 1.0 0.8089325155352028 4 P40763 1 +Cellular response to external stimulus 0.333234418061152 0.8402698720227706 0.4007570897696981 1.0 0.8089325155352028 40 Q9H773,Q99439 2 +Amp biosynthetic process 0.4406582472666285 0.8397834505479564 0.4010298141607951 1.0 0.8089325155352028 11 P22102,P30520,P07741,O15067,P55263,P30566 6 +Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.5240334238396652 0.8373686604546986 0.4023853760411615 1.0 0.8110396576486897 6 Q99816,O43633 2 +Positive regulation of histone modification 0.3547658462057102 0.8363567842647185 0.4029542167962829 1.0 0.8118351396174863 32 Q13363,P61964,Q9ULX6,Q9H3P2,Q12824,Q6PD62 6 +Cellular response to abiotic stimulus 0.315488483322096 0.8321927849956396 0.4053001357306982 1.0 0.8139243608865341 57 Q9H1E3,Q15555,Q9Y624,Q99439,P62993,P29692,Q9Y376,P48506,P16989,Q9NXR7,Q07812,P05198,P50570,P09884,P35237 15 +Transcription elongation from rna polymerase ii promoter 0.3813315426798637 0.8320382001404324 0.4053873827781813 1.0 0.8139243608865341 20 Q6IA86,Q15061,Q4G0J3,Q8WX92,Q9H3P2,Q6PD62,Q9NYV4,O00267,O14776 9 +Protein localization to cell cell junction 0.4847870937078609 0.8309776812459155 0.4059862377763481 1.0 0.8139243608865341 8 Q9UDY2,P18206,Q13177,Q9Y624 4 +Dna recombination 0.2962050195685159 0.8309596097307773 0.4059964469955135 1.0 0.8139243608865341 84 Q9H1E3,Q15645,Q15631,Q9H4L7,P35637,Q7Z4V5,Q9UQ84,Q9BXW9,Q9BRT9,Q9NRR5,P46063,P43246,O15347,P15927,Q15014 15 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.4343621342823607 0.8294042829683362 0.4068756787528551 1.0 0.8139243608865341 12 Q96A26,O95831,Q92688,O75340 4 +Neural crest formation 0.5546100633366029 0.829317249492617 0.4069249126242691 1.0 0.8139243608865341 5 O75340,Q9UBV8 2 +Epithelial cell morphogenesis 0.5220492429821817 0.8289045989874292 0.407158392802355 1.0 0.8139243608865341 6 Q8WX93 1 +Vitamin metabolic process 0.3787107868806132 0.8277764593368067 0.4077971087586576 1.0 0.8139243608865341 21 P41440,Q9H2D1,Q99707,P34896,P48506,Q9NRN7,P38435,O60678 8 +Vascular endothelial cell proliferation 0.7248569092395799 0.8273994111388485 0.4080107142415081 1.0 0.8139243608865341 2 P40763 1 +Positive regulation of vascular endothelial cell proliferation 0.7248569092395799 0.8273994111388485 0.4080107142415081 1.0 0.8139243608865341 2 P40763 1 +Positive regulation of dendritic cell differentiation 0.7248569092395789 0.8273994111388442 0.4080107142415106 1.0 0.8139243608865341 2 P17931 1 +Regulation of dendritic spine development 0.4838376476618017 0.8266230128032909 0.408450769617954 1.0 0.8141469562551217 8 Q14444,Q9UQB8,P78344 3 +Apical protein localization 0.7231579387104483 0.8265086621276022 0.4085156063914588 1.0 0.8141469562551217 3 P35241 1 +Negative regulation of cell development 0.4121264439050854 0.8253769472015471 0.4091576185660497 1.0 0.8145709373457815 16 Q8N0X7,O14786,Q00535,Q9UPY3,Q9P258,Q96G23 6 +Regulation of dendritic cell differentiation 0.7225367238802045 0.8243052614523881 0.4097661297930708 1.0 0.8145709373457815 3 P17931 1 +Cellular response to nitrogen compound 0.2759248624260448 0.8240484613213169 0.4099120227205559 1.0 0.8145709373457815 109 Q9UQB8,Q99729,P48506,O60828,P43490,P08670,Q06124,O60343,P07741,P62993,P34896,Q6PKG0,Q99707,Q9Y5X3,P35609,P15311,Q9H1E3,P41440,O95831,Q96A49,O14745,P50570,P17655,P27695,P40763,Q00535,O14744,P11802,P28161,Q5TDH0 30 +Protein localization to microtubule organizing center 0.5045085553389854 0.8237085070077195 0.4101052045765478 1.0 0.8145709373457815 7 Q15691 1 +Regulation of transcription elongation from rna polymerase ii promoter 0.4328927505308143 0.8217041393748302 0.411245302734418 1.0 0.8158061166469339 12 Q15061,Q4G0J3,Q8WX92,Q9H3P2,Q9NYV4,O14776 6 +Regulation of protein phosphorylation 0.2771388048357843 0.8213495113769168 0.4114472132950286 1.0 0.8158061166469339 130 P04792,Q9H7B4,Q04637,P61586,P23381,Q06124,P14174,Q9Y376,Q13526,P54652,P41440,Q99816,Q9H223,Q96A49,O14745,Q9NYV4,Q99627,Q96B36,Q9H2J4,Q13148,O95684,Q9ULX6,P0DP25 23 +Cellular transition metal ion homeostasis 0.4222535053920247 0.8172034492214958 0.4138121717184475 1.0 0.8179568000476406 14 Q15904 1 +Negative regulation of atp metabolic process 0.4816338733516246 0.816528449438705 0.414197958956418 1.0 0.8179568000476406 8 P61586,P40763 2 +Extracellular exosome assembly 0.7215862632870036 0.8149346081854841 0.4151097418555896 1.0 0.8179568000476406 2 Q99816 1 +Purine nucleoside monophosphate metabolic process 0.3950461787015402 0.8132504706453105 0.4160744678740062 1.0 0.8179568000476406 18 P22102,P30520,P07741,P00491,Q9UDY2,P00568,O15067,P55263,P30566,P11908 10 +Regulation of notch signaling pathway 0.7190839847212811 0.8120798733817929 0.4167458011278766 1.0 0.8179568000476406 3 Q9Y5A9 1 +Regulation of anion transport 0.5016636643649535 0.811214136634887 0.4172427087218902 1.0 0.8179568000476406 7 P14174,Q15042 2 +Hematopoietic progenitor cell differentiation 0.3659268343000565 0.8094879125825782 0.4182345527711786 1.0 0.8179568000476406 25 Q9Y5A9,Q9NQW6,Q6NXE6,O15047,Q96J02 5 +Positive regulation of neurotransmitter transport 0.6037120116044843 0.8088601320772386 0.4185956033059539 1.0 0.8179568000476406 4 Q15042 1 +Spinal cord development 0.4587716846921497 0.8082435594038524 0.4189503864689863 1.0 0.8179568000476406 9 Q14203,O75312,Q6Y7W6,P25325 4 +Positive regulation of ubiquitin protein transferase activity 0.4797871358853046 0.8080838616008406 0.4190423072981191 1.0 0.8179568000476406 8 P63208,Q16763,Q13526,P68036 4 +Positive regulation of gene expression 0.2942791715851322 0.8059984488694708 0.4202437434799926 1.0 0.8179568000476406 195 O60684,P34913,P04792,Q96PU8,Q99729,P60228,Q9Y2W1,P67809,P78344,P04083,O60828,Q96AE4,P98175,P98179,Q14011,P61586,P08670,Q04637,P43246,P23381,Q06124,P35579,P14174,Q96EP5,Q99439,P35241,Q567V2,P56537,Q8NCA5,P15311,P51116,P16989,P41440,Q7Z478,O14737,Q02952,Q9NUQ9,Q9H2J4,Q9Y5A9,P35637,Q13148,P04406,P40763,Q9ULK4,P46777,O75312,Q92804,Q07666,Q99584 49 +Negative regulation of ubiquitin protein ligase activity 0.5164055429135054 0.8049014596162796 0.4208765460507973 1.0 0.8179568000476406 6 P61927 1 +Pteridine containing compound metabolic process 0.4143486759737672 0.8040346864696118 0.4213769429016794 1.0 0.8179568000476406 15 P41440,Q9H2D1,Q99707,P34896,Q9NRN7 5 +Establishment of cell polarity 0.3525768582768118 0.8039493668690175 0.4214262176265808 1.0 0.8179568000476406 31 P35579,P15311,Q9NUQ9,O14745,Q9UNZ2,P26038,Q14203,Q13112,P60953,P61586,O43264,P61026,Q7Z460 13 +Regulation of potassium ion transport 0.4456733178289704 0.802577254171642 0.4222191195946321 1.0 0.8179568000476406 10 Q9Y376,P35609,P50570 3 +Purine nucleoside monophosphate biosynthetic process 0.4242567649499801 0.800608495142992 0.4233583311794016 1.0 0.8179568000476406 13 P22102,P49915,P30520,P07741,O15067,P55263,P30566,P11908 8 +Positive regulation of cell growth 0.3674616243736242 0.8003490290555734 0.4235086038626119 1.0 0.8179568000476406 24 O95684,P78344,O14786,Q15418,Q04637,Q8IYB8,P61586,Q7Z4V5 8 +Bone development 0.3764362263777029 0.8001744018084568 0.4236097587545897 1.0 0.8179568000476406 20 Q15904 1 +Protein localization to endoplasmic reticulum 0.3568788746342881 0.799624648690872 0.4239283020234898 1.0 0.8179568000476406 28 P61009,P20290,O76094,Q15042,Q5JRA6 5 +Regulation of dopamine receptor signaling pathway 0.717089125102213 0.7978638865101502 0.4249494823801107 1.0 0.8179568000476406 2 O14744 1 +Positive regulation of dopamine receptor signaling pathway 0.717089125102213 0.7978638865101502 0.4249494823801107 1.0 0.8179568000476406 2 O14744 1 +Dendritic spine maintenance 0.717089125102212 0.7978638865101456 0.4249494823801134 1.0 0.8179568000476406 2 Q14247 1 +Regulation of supramolecular fiber organization 0.2950886038038207 0.797571406446405 0.4251192496384659 1.0 0.8179568000476406 75 Q9NYL9,Q9UHV9,Q9UQB8,Q9Y624,Q14203,Q14019,P16949,O15143,O14786,O15144,Q99471,P61586,P61758,P62993,Q14247,P35241,O15212,P35609,Q02790,Q9Y281,Q9BTW9,Q9NUQ9,Q15691,Q92747 24 +T cell activation 0.3240460723426571 0.793858291735289 0.4272779329228577 1.0 0.8179568000476406 43 Q9NUQ9,P04083,Q9BXW9,P40763,P61586,Q96J02,P17812 7 +Peptidyl lysine trimethylation 0.4175622181603408 0.7915904161311785 0.4285995369264719 1.0 0.8179568000476406 14 Q6PD62 1 +Positive regulation of filopodium assembly 0.5453381360533559 0.7915826022301199 0.4286040945821292 1.0 0.8179568000476406 5 O14786,P11233 2 +Regulation of blood pressure 0.4222828066423671 0.7900940221057191 0.4294728607461198 1.0 0.8185541048869549 13 P61586,Q9HB40,Q9UIQ6 3 +Multicellular organismal movement 0.4967987012269596 0.7899171760087926 0.4295761397466322 1.0 0.8185541048869549 7 Q6Y7W6 1 +Glomerular epithelial cell differentiation 0.5982100193053305 0.7878170513467062 0.4308037257257131 1.0 0.8193152826927476 4 P80723 1 +Retina vasculature morphogenesis in camera type eye 0.7138184791496365 0.7855004348857054 0.4321602154422708 1.0 0.8204570277885973 2 O14786 1 +Retina vasculature development in camera type eye 0.7138184791496365 0.7855004348857054 0.4321602154422708 1.0 0.8204570277885973 2 O14786 1 +Regulation of mitochondrial atp synthesis coupled electron transport 0.7112474437627825 0.7844714284874534 0.4327635405052306 1.0 0.8211003930759186 3 P14635,Q9H3K2 2 +Organophosphate ester transport 0.3720059455019186 0.7835352630273881 0.4333128545149129 1.0 0.821319589080483 21 O00400,P02656 2 +Cellular modified amino acid catabolic process 0.5423327174913437 0.7794156221255254 0.435734924252761 1.0 0.821883877011591 5 Q9UJ14,Q9UHG3 2 +Serine phosphorylation of stat protein 0.7121831561733487 0.7793355259359905 0.4357820926343319 1.0 0.821883877011591 2 Q00535 1 +Metaphase anaphase transition of cell cycle 0.3729357122817069 0.777498535690376 0.4368646980429083 1.0 0.821883877011591 20 P14635,Q15645,P30260,P12270,Q9Y6G9,Q9UJX4,Q9UJX2,P06400,O43264,O43683,O43684 11 +Positive regulation of protein localization to early endosome 0.7092024539877205 0.777300069075937 0.4369817543066383 1.0 0.821883877011591 3 P15311,P35241 2 +Regulation of protein localization to endosome 0.7092024539877205 0.777300069075937 0.4369817543066383 1.0 0.821883877011591 3 P15311,P35241 2 +Endocrine process 0.709008368601655 0.7766201901654207 0.4373828860168438 1.0 0.821883877011591 3 P61586 1 +Supramolecular fiber organization 0.2763620937938147 0.7763817496237732 0.4375236172250529 1.0 0.821883877011591 135 Q9NYL9,Q9UHV9,Q9UQB8,Q9Y624,Q14203,Q14019,P16949,O15143,O14786,O15144,Q99471,P61586,P61758,P08670,Q96AY3,Q14247,P62993,P35241,Q13526,O60568,P59998,O75718,O00151,O15212,P35609,Q02790,P15311,Q9Y281,Q05682,Q9BTW9,Q9Y5K6,Q9NUQ9,Q96S59,Q15942,Q15691,Q07812,P07197,Q92747 38 +Respiratory burst 0.7086353389754565 0.7753138343173244 0.4381542365838078 1.0 0.821883877011591 3 P18669 1 +Cellular component assembly involved in morphogenesis 0.4143149691892708 0.7739371167713759 0.4389679788235063 1.0 0.8223201051263874 14 Q9UPY3,Q9NYL9,Q9NR77,Q9Y281 4 +Positive regulation of dna methylation dependent heterochromatin assembly 0.5405253394707721 0.7721149194595467 0.4400463665354501 1.0 0.8233467719750364 5 Q13263 1 +Vascular associated smooth muscle cell proliferation 0.4919681531537107 0.7688633027580666 0.4419744645887951 1.0 0.824791170202193 7 P61586 1 +Regulation of chromatin organization 0.4022457482635867 0.7688015647367222 0.4420111198496839 1.0 0.824791170202193 16 Q6PD62 1 +Mitotic dna replication 0.4708772497465699 0.7675418771945041 0.4427594046919338 1.0 0.824791170202193 8 Q9BY42,P09884,P33993,P33991 4 +Meiotic chromosome condensation 0.5928805237315836 0.7675334429372341 0.4427644172845841 1.0 0.824791170202193 4 Q9NTJ3,O95347,Q15021 3 +Immunological synapse formation 0.7089125102207732 0.7670402549436474 0.4430575819695943 1.0 0.824791170202193 2 P17931 1 +Vesicle localization 0.3190870425934757 0.7663389088123173 0.4434746726739327 1.0 0.824791170202193 47 O75340,O43633,P50570,Q92734,P27695,Q99816,Q9UN37,Q92905,Q9BVK6,Q9UBV8,Q00535,Q9Y2T2,Q96AX1,O60763,P33176 15 +Spliceosomal complex assembly 0.327953369398809 0.7655160532064915 0.4439643109563356 1.0 0.8252075339834911 39 Q15428,Q13247,Q99590,Q15637,Q8WXF0,Q16637 6 +Microtubule polymerization or depolymerization 0.350602254291451 0.7636234454750237 0.4450916733785455 1.0 0.8265607929667368 29 Q15555,Q14203,Q9BTW9,P16949,Q13526,Q15691,Q02790 7 +Mononuclear cell differentiation 0.3273196186337292 0.7600484035273564 0.4472256524500393 1.0 0.828276203711449 39 P04083,P55327,Q9BXW9,P40763,P17931,P61586,P43246,O15347 8 +Pyrimidine nucleobase metabolic process 0.4244827186615267 0.7572126438812846 0.4489224763736574 1.0 0.8299519435190273 11 P30085,Q05682,Q9NRF8,P11172,P17812 5 +Negative regulation of cellular response to growth factor stimulus 0.5049837079011296 0.7566812517014226 0.4492408496815812 1.0 0.8302933561079224 6 O75340,Q8N0X7,Q9Y2U8 3 +Negative regulation of microtubule polymerization or depolymerization 0.468064355878221 0.7548167152689925 0.4503589630614546 1.0 0.8310294447018429 8 Q15691,Q02790,P16949 3 +Negative regulation of translational initiation 0.4885337547678053 0.7539544221227868 0.4508765901778551 1.0 0.8315840882104187 7 P60228,P05198 2 +Muscle cell apoptotic process 0.4673949529796339 0.7517940125300394 0.4521749432575503 1.0 0.8328152968508624 8 Q9NQ88,P04179,P17655 3 +Midbrain development 0.3921664960767402 0.7511196705259474 0.4525806385446582 1.0 0.8329951883113005 17 P61586,P80723,P0DP25 3 +Cellular response to cold 0.7044153720359818 0.750211793533358 0.4531271569635673 1.0 0.8332601849996307 2 P17612 1 +Negative regulation of cellular amide metabolic process 0.2907186727273384 0.7470656713300476 0.4550239207015965 1.0 0.8338678754568283 75 Q92945,P60228,P67809,P00374,Q14011,Q9Y2L1,Q04637,Q92600,P26196,P34896,Q6PKG0,P56537,Q13526,P51116,Q92900,Q9C0B1,P05198,Q6Y7W6,Q9Y5A9,P27695,Q13148,P04406,P40763,Q969T7 24 +Regulation of extracellular matrix organization 0.5873082405707556 0.7464379083520781 0.4554029267614017 1.0 0.8339876659358021 4 Q7Z460,P06400 2 +Positive regulation of extracellular matrix organization 0.5873082405707556 0.7464379083520781 0.4554029267614017 1.0 0.8339876659358021 4 Q7Z460,P06400 2 +Negative regulation of single stranded viral rna replication via double stranded dna intermediate 0.5872337484680379 0.7461567065816594 0.4555727573268466 1.0 0.834052719044728 4 Q13263 1 +Regulation of syncytium formation by plasma membrane fusion 0.5331263808565954 0.7423615913844314 0.4578682840005106 1.0 0.8367751747036994 5 Q9H4M9,P41440 2 +Positive regulation of syncytium formation by plasma membrane fusion 0.5331263808565954 0.7423615913844314 0.4578682840005106 1.0 0.8367751747036994 5 Q9H4M9,P41440 2 +Regulation of myoblast fusion 0.5331263808565954 0.7423615913844314 0.4578682840005106 1.0 0.8367751747036994 5 Q9H4M9,P41440 2 +Positive regulation of myoblast fusion 0.5331263808565954 0.7423615913844314 0.4578682840005106 1.0 0.8367751747036994 5 Q9H4M9,P41440 2 +Regulation of rna export from nucleus 0.4651558895267691 0.7416995468662433 0.4582693944233531 1.0 0.8370155704026538 8 Q08J23,Q9ULX6,Q07666 3 +Regulation of nucleobase containing compound transport 0.4651558895267691 0.7416995468662433 0.4582693944233531 1.0 0.8370155704026538 8 Q08J23,Q9ULX6,Q07666 3 +Response to interferon gamma 0.363119742696758 0.738374053911515 0.4602871769031602 1.0 0.8399253293122553 22 P19474 1 +Protein methylation 0.3116143831125428 0.7339181100898393 0.4629986488372575 1.0 0.8422552570992782 52 P61964,Q5VTR2,Q9H9B1,Q86X55,Q8NCA5,Q9H3P2,Q99873,Q12824,O14744,Q9H7B4,Q6PD62,O60678,O15047 13 +Negative regulation of protein metabolic process 0.2902621430325111 0.7305459674492092 0.4650565258787469 1.0 0.8422552570992782 229 Q9UHV9,P04792,P60228,P48506,P00374,P19474,Q14011,Q99471,Q9H7B4,Q04637,P61758,Q12824,Q9Y2L1,P23381,Q01105,Q92600,Q13363,P14174,O43768,O60271,P34896,Q15392,P20810,P56537,Q13526,Q15257,O75718,P61927,O15212,P61964,Q99816,Q9C0B1,Q6Y7W6,P35237,O60678,O75592,Q96B36,Q9H2J4,P11413,Q9Y5A9,P27695,Q13148,O95684,Q04323,P40763,P0DP25,P17931,P46777,Q00535,Q969T7,Q92530 51 +Response to abiotic stimulus 0.2860533990508317 0.7299805485815237 0.4654020744595097 1.0 0.8422552570992782 174 Q9UNS2,Q9Y624,P04179,P04083,Q15904,Q9NXR7,Q14011,P61586,Q92547,P43246,O75340,Q8N511,Q15555,Q99439,Q9Y376,P62993,P29692,Q13526,P54652,Q96A26,Q9H1E3,P16989,O95831,Q02952,P25685,Q9NQ88,P35237,O75592,Q6P6C2,Q9UI10,Q9NR50,Q9BXW9,Q00535,P17655,P55786 35 +Tube development 0.2736894047579145 0.7294862427139529 0.4657042801013653 1.0 0.8422552570992782 105 O75340,Q9H2J4,P04792,Q96T37,Q13247,P80723,Q9BXJ9,P09960,P04083,P35613,O60568,P40763,P61586,Q96AY3,Q5JRA6 15 +Rna modification 0.32063490656275 0.7292960756302479 0.4658205723012967 1.0 0.8422552570992782 40 Q69YN4,Q9NWX6,Q96T37,Q8IZ69,Q6P6C2,P57081,O75648,Q9C0B1,Q7L2J0,Q9BV44 10 +Response to nitric oxide 0.5298576576542355 0.7292895246918751 0.4658245786607244 1.0 0.8422552570992782 5 O95831 1 +Cellular response to reactive nitrogen species 0.5298576576542355 0.7292895246918751 0.4658245786607244 1.0 0.8422552570992782 5 O95831 1 +Negative regulation of defense response 0.3544600834225251 0.729107213148314 0.4659360826666181 1.0 0.8422552570992782 25 Q96J02,P19474,P28070 3 +Heterochromatin organization 0.3570922999703195 0.728995460957527 0.466004439023161 1.0 0.8422552570992782 24 Q13363 1 +Myeloid cell development 0.4188310022856676 0.7287057737904968 0.4661816602180217 1.0 0.8422552570992782 11 Q15904,Q13310,P11413,Q06124 4 +Cell cell adhesion via plasma membrane adhesion molecules 0.4825958684615657 0.728303745989663 0.4664276697527243 1.0 0.8422552570992782 7 P35613 1 +Pentose metabolic process 0.5293300999547925 0.7271841108463277 0.4671131784294582 1.0 0.8423404129069838 5 Q8NBZ7 1 +Bergmann glial cell differentiation 0.5293137882000908 0.7271190323925107 0.4671530405880277 1.0 0.8423404129069838 5 P08670,Q06124 2 +Negative regulation of viral process 0.3730091526365938 0.7262370009597842 0.4676934926037037 1.0 0.8430701274510886 19 Q99549,Q12899,P19474,P78362,Q13325,Q13263,Q14258 7 +Regulation of hydrolase activity 0.2721045560693699 0.7258460868210836 0.467933130357606 1.0 0.843178622164071 133 P02656,Q9Y624,P04083,P16949,P61586,O75340,Q15555,O60343,P40616,Q15392,P20810,P35241,Q13526,Q15257,Q8TC07,Q96A26,P18085,Q92688,O95831,O14737,Q15042,P05198,Q9P258,P35237,O43847,O00273,Q9NVX2,Q04323,Q9NR28,P04406,P49354,P40763,P0DP25,P17931,Q07812,Q15418,Q92530 37 +Bone mineralization 0.4975758806257725 0.7256958683600135 0.4680252352012162 1.0 0.843178622164071 6 Q9NUQ3,Q9UNW1 2 +Positive regulation of rna binding 0.5286266877274343 0.7243788057997926 0.4688332078808974 1.0 0.8441266365550605 5 Q04637 1 +External encapsulating structure organization 0.3642475595103543 0.7216651033166087 0.4705004020246361 1.0 0.8451858537960633 20 Q96AY3,O60568,P11047,P41440 4 +Cell substrate junction organization 0.3605421731652372 0.7213491178042333 0.470694743881229 1.0 0.8452904452002407 22 P51452,Q15555,Q14247,P11047,P12814,O14786,P18206,Q15149,Q9Y490,P61586,Q9P258,P35609 12 +Renal absorption 0.6962387571545443 0.719856562641443 0.471613314861965 1.0 0.845631292686711 2 O14745 1 +Renal sodium ion transport 0.6962387571545443 0.719856562641443 0.471613314861965 1.0 0.845631292686711 2 O14745 1 +Negative regulation of protein tyrosine kinase activity 0.5273950472105676 0.719472196098773 0.4718500274911723 1.0 0.845631292686711 5 O95684 1 +Regulation of translational termination 0.5272945402107514 0.7190720989838976 0.472096497357001 1.0 0.845631292686711 5 Q8N543 1 +Toxin transport 0.408707088453826 0.7184295090682301 0.4724924972865849 1.0 0.845631292686711 13 P17987,P35606,P78371,Q15650,O14786,P61923 6 +Regulation of substrate adhesion dependent cell spreading 0.3988521097718187 0.7181662496060499 0.4726547853326206 1.0 0.845631292686711 15 O14786,O15144,P50570,Q9P258,Q92766 5 +Mitotic dna integrity checkpoint signaling 0.3578501537741908 0.7178559213721523 0.4728461286413137 1.0 0.8456384294209122 23 Q92547,Q9BXW9,Q9NXR7,Q6Y7W6,P15927 5 +Cell part morphogenesis 0.28424585409524 0.716087271895865 0.4739374625270214 1.0 0.8460537987103172 90 Q9UQB8,Q16555,O60828,P78344,O60749,P16949,O14786,Q13596,Q15149,P61586,P33176,Q06124,Q8TEY7,Q8WX93,Q04917,O60271,Q14247,Q96HC4,Q9UPY3,O95372,P41440,P35613,P60953,P50570,O60678,O75592,Q92766,Q99829,P11047,Q13177,Q8N0X7,P18206,Q07812,Q00535,Q8IYB8 35 +Rna catabolic process 0.2682513125140955 0.7151866913324001 0.4744936915448514 1.0 0.8460537987103172 109 Q92945,Q99729,P60228,P51530,Q9Y2W1,P67809,P62312,P98175,Q08J23,Q14011,Q9Y2L1,P08670,Q9H814,Q9Y2V2,Q9UPY3,O00178,P51116,P16989,Q92900,Q9C0B1,Q6Y7W6,Q5TBB1,Q9Y5A9,P27695,P35637,Q6P6C2,Q13148,Q8NC51,Q8IYB8,Q13310,O75312,Q92804,Q969T7 33 +Dna double strand break processing 0.4792351319950656 0.713861099564598 0.4753130737671358 1.0 0.8460692671961049 7 Q9NW82,Q9H4L7 2 +Leukotriene metabolic process 0.5259686216285075 0.7137982204012383 0.4753519602652511 1.0 0.8460692671961049 5 Q9UJ14,P09960 2 +Aspartate family amino acid biosynthetic process 0.4274298705545819 0.7135033058665358 0.4755343681931783 1.0 0.8461514115987498 10 Q99707,O60568,Q13126 3 +Positive regulation of small gtpase mediated signal transduction 0.5784693968771453 0.7132296658721355 0.4757036519138244 1.0 0.8462101628143368 4 Q15555,Q9Y624 2 +Regulation of exocytosis 0.3422148087216671 0.7123742990345567 0.4762330262047689 1.0 0.84654198353755 30 O43633,P27695,Q99816,P20339,Q9UN37,P04083,P0DP25,Q15042,Q00535,O43747 10 +Rna methylation 0.3566280463055205 0.709678747393641 0.4779033742469858 1.0 0.8479371297353663 23 Q69YN4,Q96T37,Q8IZ69,P57081,O75648,Q7L2J0,Q9BV44 7 +Regulation of cell adhesion 0.2871010603500997 0.7077820144959996 0.4790806370375258 1.0 0.8494886596031267 72 Q9Y624,P04083,O14786,O15144,P61586,Q5JRA6,Q06124,Q13630,P35241,P41440,Q9BTW9,P52565,P50570,Q9P258,Q92766,Q9NUQ9,Q9Y5A9,P17931,Q96J02 19 +Transition metal ion homeostasis 0.3699674007993641 0.7074732521500121 0.4792724291591859 1.0 0.8494886596031267 19 Q15904,Q8N511 2 +Epithelial cell development 0.3413454186445927 0.7058883871351288 0.4802575499097965 1.0 0.8496866209910956 30 P15311,Q8WX93,Q9Y624,P35241,P11047,Q9UDY2,O60568,P18206,Q15149,Q9NQ88,P08670,Q9Y696 12 +Humoral immune response 0.4062071150167 0.7053696350890516 0.4805802355202107 1.0 0.8496866209910956 13 Q9UQ84,Q9Y5A9 2 +Intermediate filament organization 0.5237759012873265 0.7050945123558706 0.4807514213700434 1.0 0.8496866209910956 5 P07197,P08670,Q15149 3 +Biological process involved in interaction with symbiont 0.3580345515243299 0.7048511738053008 0.480902858261075 1.0 0.8496866209910956 22 Q13148,P81605,O14646,Q9H1E3 4 +Regulation of cysteine type endopeptidase activity 0.3264570011680877 0.7043208655520511 0.4812329750043083 1.0 0.8499592647260393 37 O75340,Q96A26,Q9NVX2,P20810,Q15392,Q92688,Q9NR28,O95831,O14737,Q07812,P61586 11 +Establishment of sister chromatid cohesion 0.6913327882256797 0.701801671081781 0.4828028564997417 1.0 0.850981211594447 2 Q9GZZ1 1 +Dna replication synthesis of rna primer 0.687116564417175 0.700822821143189 0.4834135941835695 1.0 0.8515919876035049 3 P49642,P09884 2 +Embryonic pattern specification 0.522020202496532 0.6981419336030191 0.4850884358070928 1.0 0.853370874323526 5 P80723 1 +Pyridine containing compound catabolic process 0.6901062959934651 0.6973073102684049 0.4856104941424719 1.0 0.8536293594963494 2 Q13126 1 +Blastoderm segmentation 0.5740873689787682 0.6968899156228587 0.4858716892253198 1.0 0.8537813214740341 4 P80723 1 +Cellular response to thyroid hormone stimulus 0.6854805725971237 0.6952346854364154 0.486908238623108 1.0 0.8546070494737517 3 P35241,P48506 2 +Vasculogenesis 0.5211336083735488 0.6946366768757596 0.4872830211421468 1.0 0.8546070494737517 5 Q96PU8 1 +Sex differentiation 0.3398074286428602 0.6944383409692388 0.4874073561453786 1.0 0.8546070494737517 30 P49321,Q02790,P16989,O75874,P80723,Q15392,Q15637,P43246,Q06124 9 +Blastocyst growth 0.4897226600003137 0.6931279556444776 0.4882292552105816 1.0 0.8555032942600767 6 P61201,Q9BRT9,Q6PD62,O75312 4 +Cell cell junction organization 0.3339469314835563 0.689927115684265 0.4902400227734402 1.0 0.8558779511837933 33 Q9Y624,P17612,P60953,Q8WUM4,P35241,Q9BTW9,Q9UDY2,Q13177,P18206,Q15149,Q9Y490,P61586 12 +Cell morphogenesis involved in differentiation 0.2777879166910775 0.6899117574553824 0.4902496815370258 1.0 0.8558779511837933 97 Q9UQB8,O60828,P78344,P16949,O14786,O15144,P61586,P33176,Q06124,P35579,Q8TEY7,Q8WX93,Q04917,Q14247,O60568,O95372,P41440,Q9BTW9,P35613,O14745,P50570,Q9P258,O60678,O75592,Q92766,Q9Y5A9,P11047,Q8N0X7,Q00535,Q96AX1 30 +Centrosome separation 0.5717803657707908 0.6883224502489421 0.4912497471419148 1.0 0.8560976473818418 4 P52732,Q9UNZ2 2 +Positive regulation of mrna splicing via spliceosome 0.3878546635133166 0.6876651451933077 0.4916636739357813 1.0 0.8560976473818418 16 Q96EP5,P38159,Q9Y2W1,P98179,Q14011 5 +Lymphocyte activation 0.2852685760672885 0.6870950580031706 0.49202282829012 1.0 0.8560976473818418 79 Q9NUQ9,P14174,Q9UQ84,P04083,Q9BXW9,P40763,P61586,P43246,O15347,Q96J02,P17812 11 +Homologous recombination 0.4529251643009584 0.6870303792938932 0.4920635847004726 1.0 0.8560976473818418 8 Q9BXW9,Q9H1E3 2 +Execution phase of apoptosis 0.4104071966909014 0.6866079707140791 0.4923298042647981 1.0 0.8560976473818418 11 O95831,Q9UPY3 2 +Regulation of dna primase activity 0.6868356500408883 0.6853612836769779 0.4931159687979427 1.0 0.8560976473818418 2 Q9BRT9 1 +Inner ear receptor cell development 0.5186646128523538 0.6848956420067354 0.4934097762205645 1.0 0.8560976473818418 5 Q9BW83 1 +Post chaperonin tubulin folding pathway 0.6823901326237782 0.6847098632706529 0.493527023782832 1.0 0.8560976473818418 3 Q15813 1 +Negative regulation of transferase activity 0.3095911052061982 0.6843615751405681 0.4937468734906134 1.0 0.8560976473818418 48 Q96B36,P04792,Q99816,O95684,P61927,Q9H7B4,P23381 7 +Cell matrix adhesion 0.3450683949801004 0.6832176182604935 0.4944693413914072 1.0 0.8560976473818418 26 Q13630,P51452,Q15942,Q9UM22,O14786,Q00535,P61586,Q9P258,P35609 9 +Cellular carbohydrate metabolic process 0.3100438762223435 0.6829532723815925 0.4946363698445495 1.0 0.8560976473818418 47 P48735,O75874 2 +Regulation of synaptic vesicle exocytosis 0.4519953761021081 0.6829094598256391 0.4946640559717268 1.0 0.8560976473818418 8 P20339,P0DP25,Q15042 3 +Nucleotide transport 0.4203655915932164 0.6795542503848084 0.4967867460108834 1.0 0.8560976473818418 10 O00400,P41440 2 +Megakaryocyte development 0.6852003270646009 0.6794098939921813 0.4968781826162294 1.0 0.8560976473818418 2 Q06124 1 +G0 to g1 transition 0.6852003270646005 0.6794098939921802 0.49687818261623 1.0 0.8560976473818418 2 P23921 1 +Regulation of g0 to g1 transition 0.6852003270646005 0.6794098939921802 0.49687818261623 1.0 0.8560976473818418 2 P23921 1 +Positive regulation of g0 to g1 transition 0.6852003270646005 0.6794098939921802 0.49687818261623 1.0 0.8560976473818418 2 P23921 1 +Enucleate erythrocyte differentiation 0.6852003270646007 0.6794098939921792 0.4968781826162307 1.0 0.8560976473818418 2 P06400 1 +Mrna 3 splice site recognition 0.5172242496096287 0.6792270704851543 0.4969939975005317 1.0 0.8560976473818418 5 Q15428 1 +Organelle fusion 0.337734553572945 0.6790560105290613 0.4971023734445963 1.0 0.8560976473818418 30 Q9NWX6,Q15075,P04083 3 +Regulation of double strand break repair via homologous recombination 0.357536313797564 0.6790350740589491 0.4971156387212434 1.0 0.8560976473818418 20 P35637,Q9NRR5,P15927,Q15014 4 +Response to endogenous stimulus 0.2874608295964092 0.6786066481204849 0.497387129356603 1.0 0.8563277164692278 224 Q9UQB8,O75874,P48506,P04083,P43490,O15143,Q9H7B4,P61586,Q9UQ13,Q5JRA6,Q92600,Q06124,O60343,P07741,Q9Y376,P62993,P34896,Q15392,P35241,Q86X55,P56537,Q9Y5X3,O00400,Q13526,Q14258,P35609,Q02790,Q9H1E3,Q9Y2U8,Q9H4M9,Q13247,P09960,P35613,O95831,O14737,Q96A49,O14745,Q9NQ88,O75592,P17655,Q99829,P27695,Q15942,Q9UI10,Q9NR50,P49354,P40763,P0DP25,Q8N0X7,Q00535,O14744,P11802,P28161,O75312 54 +Regulation of potassium ion transmembrane transporter activity 0.4509360733652349 0.6782209657691056 0.4976316011906414 1.0 0.8565111539340032 8 Q9Y376,P35609 2 +Trna thio modification 0.6847914963205287 0.67792433412767 0.4978196701104886 1.0 0.8565974373472248 2 O75648 1 +Negative regulation of supramolecular fiber organization 0.3279695325635889 0.6765754885920725 0.498675335356455 1.0 0.8573557129349377 35 Q9NYL9,Q9NUQ9,Q9UHV9,Q9Y624,P35241,P16949,Q15691,Q99471,P61758,O15212,Q02790 11 +Inner ear receptor cell stereocilium organization 0.5683265262183119 0.6755426759917458 0.4993310473914136 1.0 0.8573657729958971 4 Q9BW83 1 +Purine nucleotide transport 0.4304445110637511 0.6751904433735539 0.4995547775002271 1.0 0.8573657729958971 9 O00400 1 +Striated muscle cell development 0.4302549721394935 0.6743163225192647 0.5001102289518431 1.0 0.8573657729958971 9 Q9NYL9,Q15149,P35609,Q9Y281 4 +Viral budding 0.4696167021711233 0.6728540316998882 0.5010401592570144 1.0 0.8573657729958971 7 Q99816,O43633,Q9UN37 3 +Multivesicular body organization 0.4696167021711233 0.6728540316998882 0.5010401592570144 1.0 0.8573657729958971 7 Q99816,O43633,Q9UN37 3 +Positive regulation of histone methylation 0.3642718667613079 0.6725857701453277 0.5012108571126601 1.0 0.8573657729958971 19 Q6PD62,P61964 2 +Positive regulation of insulin secretion involved in cellular response to glucose stimulus 0.5151273763592494 0.6709938840462999 0.5022244256839716 1.0 0.8578355195460249 5 O95563 1 +Positive regulation of cytoplasmic transport 0.567020767406714 0.6707260980028428 0.5023950340031815 1.0 0.8578355195460249 4 P15311,P35241 2 +Positive regulation of early endosome to late endosome transport 0.567020767406714 0.6707260980028428 0.5023950340031815 1.0 0.8578355195460249 4 P15311,P35241 2 +Regulation of protein serine threonine kinase activity 0.3168646223867594 0.6707009991105924 0.5024110262499359 1.0 0.8578355195460249 39 P14635,P14174,P31689,Q9Y376,Q99816,Q9NYV4,Q9P287,P54619,Q96A49,P0DP25,O95373,P61586,O00410 13 +T cell receptor signaling pathway 0.3845377836862502 0.6692158124218915 0.5033578208967096 1.0 0.8585147123780736 16 P15311,Q9UI10,Q9NR50,P17931,Q07666 5 +Negative regulation of protein polymerization 0.3542250174615363 0.6681356955225782 0.5040469781939714 1.0 0.8594540731972988 21 Q9NUQ9,Q9NYL9,P35241,P16949,Q15691,Q02790 6 +Glucosamine containing compound metabolic process 0.6773006134969324 0.6674689141897037 0.5044726594467552 1.0 0.8594895738401302 3 O60502,O95394 2 +Skeletal muscle cell differentiation 0.4682490530861133 0.6670652724213093 0.5047304413082978 1.0 0.8596752716743086 7 P61201,Q9Y5Q8,P06400 3 +Regulation of behavior 0.5650477295641452 0.6634640386157876 0.5070334037809021 1.0 0.8619429065095544 4 P40763 1 +Regulation of fertilization 0.6802943581357372 0.6616447194223474 0.5081989406106773 1.0 0.8625692718315989 2 P35579 1 +Maintenance of apical basal cell polarity 0.6753247835970705 0.6608074647128316 0.5087357950500488 1.0 0.8625692718315989 3 O14745 1 +Motor neuron axon guidance 0.5124443979198173 0.660493220056486 0.5089373679395446 1.0 0.8625692718315989 5 O75592,Q00535 2 +Peptidyl methionine modification 0.6748956788975337 0.6593631495933703 0.509662599704273 1.0 0.8625692718315989 3 Q5VZE5 1 +Negative regulation of ion transport 0.3928827571306201 0.6592880391045971 0.5097108216267412 1.0 0.8625692718315989 14 Q9Y376,P30626,P0DP25,O14745,P28161 5 +Base excision repair 0.3928809413484416 0.6592784836026876 0.509716956555972 1.0 0.8625692718315989 14 P27694,P27695,Q7Z6Z7,P51530,P39748,Q07864,P23396,P15927 8 +Regulation of mrna 3 end processing 0.3928445229902556 0.6590868393550708 0.5098400062797728 1.0 0.8625692718315989 14 Q69YN4,Q8N684,Q5VTR2,Q6PD62,O00267 5 +Dephosphorylation 0.290538280497581 0.6556788829857035 0.5120307587224509 1.0 0.8643312177183159 62 Q9NPH0,P34913,O15355,Q5TFE4,Q9UNW1,Q13526,P0DP25,Q15257,Q9NQ88,Q969T7,Q06124 11 +Folic acid containing compound metabolic process 0.3964718916942084 0.6549818243572578 0.5124794563484936 1.0 0.8643312177183159 13 P34896,Q9NRN7,P41440,Q9H2D1 4 +Positive regulation of cell adhesion 0.3078959995000395 0.6547765780627339 0.5126116127335949 1.0 0.8643312177183159 45 Q13630,Q9NUQ9,P41440,P04083,P61586,Q92766,Q06124 7 +Regulation of microtubule polymerization or depolymerization 0.3535574998902032 0.6539949924247046 0.5131150318116109 1.0 0.8647067428901232 20 Q15555,Q14203,P16949,Q15691,Q02790 5 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.6778413736713058 0.6528134972196997 0.5138765210945906 1.0 0.8655202592886924 2 Q13177 1 +Positive regulation of activated t cell proliferation 0.6778413736713056 0.6528134972196994 0.5138765210945908 1.0 0.8655202592886924 2 P09429 1 +Negative regulation of wound healing 0.6728016359918219 0.652327287434913 0.5141900604130469 1.0 0.8655898183535109 3 Q7Z460,P55011 2 +Negative regulation of nervous system development 0.3999225885967875 0.6523171595566921 0.5141965925774721 1.0 0.8655898183535109 12 Q8N0X7,O14786,Q00535,Q9UPY3,Q96G23 5 +Regulation of dna damage response signal transduction by p53 class mediator 0.4250641532668315 0.6504751322170005 0.5153853598641256 1.0 0.8666512550111616 9 P14174,O43324 2 +N acetylglucosamine metabolic process 0.6770237121831619 0.649877543732089 0.5157713247392657 1.0 0.8670168036843575 2 O60502 1 +Regulation of dna templated transcription initiation 0.4248574587311575 0.6495298100777525 0.5159959847140976 1.0 0.8670168036843575 9 P09429,Q15648,P53999,Q9H2U1,Q86VP6,P11802 6 +Negative regulation of smooth muscle cell migration 0.5610950884470728 0.6489748594024425 0.5163546263206233 1.0 0.8670168036843575 4 P61586 1 +Mitochondrial depolarization 0.5609656301145528 0.6485016658042522 0.5166605337624546 1.0 0.867151868828336 4 P48506,P63244,Q9UII2 3 +Actin crosslink formation 0.6713343654637407 0.6474097822218324 0.5173667665068948 1.0 0.8674318854977074 3 Q9UQB8 1 +Lymphocyte migration 0.4243871230145832 0.6473798964963301 0.517386103684945 1.0 0.8674318854977074 9 P61586 1 +Muscle cell proliferation 0.3490790247262609 0.6465080155897966 0.517950407749239 1.0 0.8679093448793238 22 P61586,Q5VZE5,P04179 3 +Positive regulation of amine transport 0.5601472590886167 0.6455124030527927 0.5185951832470779 1.0 0.8684749394852941 4 Q15042 1 +Nuclear migration 0.4630862164277688 0.6453140432529973 0.5187236939361619 1.0 0.8684749394852941 7 Q14203,Q9Y266,O14745 3 +Secondary metabolic process 0.4623600576611735 0.6422679398060236 0.520699226898049 1.0 0.8700071430519404 7 P40616 1 +Establishment of mitotic spindle localization 0.4422367324680309 0.6399902032124793 0.5221789685375546 1.0 0.8700888690712156 8 Q14203,O43264,Q14974,Q9UNZ2 4 +Regulation of dna templated transcription elongation 0.3498030886727617 0.6399679557200508 0.5221934323717263 1.0 0.8700888690712156 21 Q15061,Q5BKZ1,Q8WX92,Q9H3P2,Q9NYV4,P43897 6 +Regulation of mitotic cell cycle 0.2636437096226316 0.6358422192062166 0.5248792664652437 1.0 0.8705379022120379 108 Q9NYL9,P04083,O43660,Q9NXR7,Q9Y6G9,Q9UJX4,Q7L2J0,Q04637,Q92547,P43246,Q06124,P51452,P31350,P30260,Q15645,P35241,Q13526,Q9NQW6,Q9UL46,P54652,Q5VTR2,P06730,O14745,Q6Y7W6,Q9P258,Q5TBB1,P27695,Q9NVX2,Q9UN37,Q7Z7L1,Q9BXW9,Q9UJX2,O14744,P11802,Q06323,P15927 36 +Cellular response to alcohol 0.3999153147363752 0.634921024440584 0.5254799241579622 1.0 0.8705379022120379 11 O95831,P04179 2 +Intermediate filament bundle assembly 0.6725265739983706 0.6338009248433922 0.5262107495573116 1.0 0.8705379022120379 2 P07197 1 +Negative regulation of keratinocyte proliferation 0.6725265739983703 0.6338009248433916 0.5262107495573121 1.0 0.8705379022120379 2 Q15648 1 +Insulin secretion involved in cellular response to glucose stimulus 0.4602920033331612 0.6336113091910658 0.5263345184509876 1.0 0.8705379022120379 7 P30626,O95563 2 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.4602920033331612 0.6336113091910658 0.5263345184509876 1.0 0.8705379022120379 7 P30626,O95563 2 +Male meiotic nuclear division 0.5564255814550682 0.6319631790707808 0.527410937800862 1.0 0.8705379022120379 4 Q15645 1 +Positive regulation of cellular component biogenesis 0.2794314154047959 0.6305066616305689 0.52836314569032 1.0 0.8705379022120379 84 O43633,Q9UQB8,Q14203,O14786,O15144,Q04637,P61586,P11233,P23381,Q15555,P62993,Q8NCA5,Q9NQW6,P41440,Q99816,Q15042,P50570,P27695,Q9UN37,Q15691,P17931,Q07812,Q13263 23 +Response to monosaccharide 0.3373564551666547 0.6295829858352149 0.5289674582368282 1.0 0.8705379022120379 26 P30626,P48506,Q9UI10,P04179,Q9NR50,O95563,Q12824,P61586 8 +Gmp biosynthetic process 0.3985676032689181 0.6283480420065449 0.5297759662299006 1.0 0.8709075043626163 11 P22102,P49915,P07741,O15067,P55263,P30566 6 +Megakaryocyte differentiation 0.4395627313487423 0.6283420371504324 0.5297798990958014 1.0 0.8709075043626163 8 Q99873,Q96T37,Q06124 3 +Negative regulation of epithelial cell apoptotic process 0.4732544282231792 0.6259094091382361 0.531374362603604 1.0 0.8709075043626163 6 Q13247 1 +Intrinsic apoptotic signaling pathway 0.2842366369396565 0.6258199587902434 0.5314330390883588 1.0 0.8709075043626163 64 O95831,P16989,P14174,P04792 4 +Response to topologically incorrect protein 0.3054199507795534 0.6244792729951858 0.5323128782588717 1.0 0.8709075043626163 41 Q9BUN8,P55145,P04792 3 +Positive regulation of peptidyl tyrosine phosphorylation 0.3937671494803795 0.6215956438297858 0.5342077861400025 1.0 0.872778308847518 12 Q9H223,P14174 2 +Serine family amino acid metabolic process 0.3893253086920003 0.6185184734075858 0.5362336242717891 1.0 0.8733187337574538 13 P34896,P48506,P00374,P49903 4 +Regulation of microtubule cytoskeleton organization 0.3183110853621015 0.6181775792212265 0.5364582877496709 1.0 0.8733187337574538 36 O43633,Q14203,Q15691,P61586,Q02790 5 +Antigen processing and presentation of exogenous antigen 0.4564764884288356 0.6177137805434257 0.5367640264400733 1.0 0.8733187337574538 7 Q9UIQ6,P50570 2 +Positive regulation of erythrocyte differentiation 0.4175863073379319 0.6164823877501499 0.537576192434174 1.0 0.8733187337574538 9 P40763,Q99873 2 +Sequestering of calcium ion 0.3846382119787115 0.6162234128633461 0.5377470780281663 1.0 0.8733187337574538 14 P28161,P30626,P0DP25,P27695 4 +Dna methylation 0.3682226419710006 0.6138592389710742 0.5393083474801224 1.0 0.8733187337574538 17 O95983,Q9H9B1,Q8NB78,O14744 4 +Positive regulation of growth 0.32203483061735 0.6134222948417414 0.5395971480797865 1.0 0.8733187337574538 34 P15311,P16989,P80723,O95684,P78344,Q15418,Q04637,O75312,Q8IYB8,P61586,Q7Z4V5 11 +Histone h2a acetylation 0.4553976223992937 0.6132364787742218 0.5397199876845697 1.0 0.8733187337574538 7 Q15014 1 +Nucleus localization 0.4360120765541427 0.6129550305686235 0.5399060746051356 1.0 0.8733187337574538 8 Q14203,Q9Y266,O14745 3 +Translational elongation 0.345137964425784 0.6105226995207655 0.5415156112672721 1.0 0.8733187337574538 21 P05387,P29692,P24534,O00178,P43897 5 +Circulatory system process 0.2955781680178536 0.6103018885291939 0.5416618461559604 1.0 0.8733187337574538 55 P28161,P41440,Q9UDY2,P04179,O60568,Q9UIQ6,O14745,Q02952,P61586,Q9HB40 10 +Regulation of ion transport 0.2942473206777447 0.6084052033638996 0.5429187612663089 1.0 0.874358274757204 56 P61586,P33176,P14174,Q9Y376,P30626,P54652,P35609,P55011,P07384,Q15042,P50570,O14745,P11413,P27695,P17931,Q07812,Q00535,P0DP25,P28161 19 +Positive regulation of gtpase activity 0.330063687944049 0.605165889045772 0.5450687781581443 1.0 0.8753237942493085 28 Q15555,O60343,Q9P258,Q13526,Q15042,Q8TC07 6 +Negative regulation of gene expression epigenetic 0.3385990489006735 0.6046967685005572 0.5453804956948693 1.0 0.8755979519816801 24 Q13363 1 +Neural crest cell differentiation 0.3899855027277384 0.6028957286694693 0.546578057653101 1.0 0.8759354162647115 12 O75340,O14786,Q9UBV8 3 +Mesenchymal cell development 0.3899855027277384 0.6028957286694693 0.546578057653101 1.0 0.8759354162647115 12 O75340,O14786,Q9UBV8 3 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.6576687116564386 0.6021263061757642 0.547090065061191 1.0 0.8762408330422339 3 P14635,Q9Y6G9 2 +Positive regulation of smooth muscle cell migration 0.6572237245806024 0.6006681236958666 0.5480610542635973 1.0 0.8765024844133245 3 P31949 1 +Response to nitrogen compound 0.2806412237496559 0.5999963912615033 0.5485086405436559 1.0 0.8767686852653065 190 Q9UQB8,P48506,O60828,P00374,P04083,P43490,Q9BUN8,P61586,Q5JRA6,Q06124,O60343,P07741,P62993,P34896,Q99707,P49721,Q86X55,P56537,Q9Y5X3,Q9UBV2,Q14258,P35609,P15311,Q9H1E3,P41440,Q13247,P09960,P35613,O95831,Q96A49,Q9Y266,O14745,P17655,P27695,Q9UI10,Q04323,Q9NR50,P40763,P0DP25,Q00535,O14744,P11802,P28161,Q969Z3 44 +Biomineralization 0.4521952668235238 0.599994534506403 0.5485098779799864 1.0 0.8767686852653065 7 Q9NUQ3,Q9UNW1 2 +Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway 0.6561804590683894 0.5972536469359638 0.5503380468424153 1.0 0.8771646873614851 3 Q9UN37 1 +Nitrogen compound transport 0.2363244980536553 0.5969840752598343 0.5505180127612075 1.0 0.8771646873614851 419 Q9NT62,Q9NVZ3,O43633,P61009,O60684,O43772,P04792,Q7Z4Q2,Q8TEX9,Q92973,O76094,P20645,P04083,Q15904,Q8N6T3,Q9BUN8,O60830,Q5JRA6,O75340,A6NIH7,Q8TAG9,Q8TBQ9,P40616,Q9H814,Q9BW83,O00400,O95563,P35606,P41440,P20290,Q92688,O95831,Q15042,O14745,Q9BXS5,P83436,O75592,Q96AX1,Q9H2D1,Q6P6C2,P20339,Q9BVK6,O00471,Q9ULX6,Q8NFH4,P40763,O43592,P55786,Q9UHB9,Q15436,Q99584 51 +Androgen receptor signaling pathway 0.3917111813026968 0.5951640206612673 0.5517338378392427 1.0 0.8776010965527631 11 P61586 1 +Scf dependent proteasomal ubiquitin dependent protein catabolic process 0.4954805554153247 0.59505446294382 0.5518070661900838 1.0 0.8776010965527631 5 P63208,Q93034 2 +Cellular response to ketone 0.3846393174694002 0.5948787583339588 0.5519245170748963 1.0 0.8776010965527631 13 Q9H7B4 1 +Cortical actin cytoskeleton organization 0.3804659240291201 0.5946912606011532 0.552049864689721 1.0 0.8776010965527631 14 P15311,Q8WUM4,Q9UN37,Q9NQW6,Q9Y2A7,Q00535,Q15149,Q9Y490 8 +Positive regulation of exocytosis 0.3879681401645388 0.5929773978968212 0.5531962785380571 1.0 0.8779307603017696 12 O43633,P20339,Q99816,Q00535,O43747 5 +Regulation of protein localization to cell surface 0.4947288428684534 0.5921957681118709 0.5537195029245503 1.0 0.8779307603017696 5 P35609,Q92538 2 +Meiotic cell cycle checkpoint signaling 0.6542408294669463 0.5909213132163975 0.5545731447375228 1.0 0.8779307603017696 3 Q15645 1 +Peptidyl amino acid modification 0.2809462505268841 0.5903409843762593 0.5549620675777942 1.0 0.8779307603017696 197 P41227,Q9H3P2,Q99873,Q9H7B4,Q04637,Q96AY3,Q01105,O15460,Q13363,Q06124,Q5VZE5,P14174,Q9Y376,Q13526,O60568,P38435,Q15257,Q6PD62,O75718,O15047,Q9Y3C6,Q15014,Q02790,Q8N543,P61964,Q9H9B1,Q9H223,O60678,Q86UY6,Q9H2H8,Q9H2J4,Q13451,O95684,P0DP25,O14744,Q9BXJ9 36 +Pyrimidine nucleoside triphosphate biosynthetic process 0.4115135292370614 0.5892097346593596 0.5557205877323206 1.0 0.8779307603017696 9 Q9BZX2,P17812,Q9NRF8 3 +Regulation of ruffle assembly 0.430164634290321 0.5878237669166173 0.556650589528856 1.0 0.8783352410231043 8 Q9P258,P35241 2 +Ruffle assembly 0.430164634290321 0.5878237669166173 0.556650589528856 1.0 0.8783352410231043 8 Q9P258,P35241 2 +Positive regulation of lipase activity 0.463694566324483 0.587656465903208 0.5567629019081473 1.0 0.8783352410231043 6 P61586 1 +Regulation of catabolic process 0.2803210749194776 0.5872967216936895 0.5570044424947607 1.0 0.8783352410231043 244 Q06323,P02656,Q92530,P04792,Q92945,O75874,Q99729,P48506,Q9Y2W1,P67809,P78344,Q99570,P19474,P98175,Q08J23,Q14011,Q13200,Q9Y2L1,Q04637,P08670,O00267,Q9ULT8,Q8TEY7,Q14247,Q6PKG0,P35241,Q9H814,Q9Y4X5,P56537,Q99460,Q13526,Q9Y5X3,Q9Y2V2,Q9UL46,Q9NRR5,P54727,P54619,O00178,P06730,P15311,P51116,P16989,P46379,P07384,Q92900,O95831,Q9C0B1,Q15042,Q9NQ88,Q6Y7W6,O75592,O43847,P21281,Q9H2J4,Q9Y5A9,P27695,P35637,Q6P6C2,O00273,Q13148,O43242,Q8NC51,Q8IYB8,Q04323,P04406,P40763,Q13310,Q00535,P46777,Q07812,P11802,P18669,Q92804,Q969T7,Q96J02 75 +Multicellular organismal response to stress 0.4931252555740865 0.5861099296146894 0.5578016439604212 1.0 0.8783352410231043 5 Q04637,P17655 2 +Regulation of epithelial cell apoptotic process 0.4487430435243684 0.5858020314839081 0.558008558410509 1.0 0.8783352410231043 7 Q13247,P20810 2 +Cellular response to oxygen radical 0.5433582863670035 0.5850084908583463 0.5585420075362704 1.0 0.8783352410231043 4 P04179 1 +Response to oxygen radical 0.5433582863670035 0.5850084908583463 0.5585420075362704 1.0 0.8783352410231043 4 P04179 1 +Amide transport 0.3246384901997632 0.583370591005465 0.5596438510598656 1.0 0.8789696141603953 30 P41440,Q9H2D1,P04083,O00400,O95563,O14745 6 +Signal transduction in response to dna damage 0.2996092476381229 0.5813790213539403 0.5609850332120017 1.0 0.8793932931636681 45 P14174,Q6Y7W6,P62993,Q9BXW9,Q9NXR7,P15927,Q92547,P43246,O43324,Q5TBB1,Q06124 11 +Positive regulation of potassium ion transmembrane transporter activity 0.5422530894200456 0.5810839264364596 0.5611838911500404 1.0 0.8793932931636681 4 P35609 1 +Mitotic cell cycle checkpoint signaling 0.3157860065547077 0.5810697641130553 0.5611934356842285 1.0 0.8793932931636681 35 Q92547,Q9BXW9,Q9NXR7,Q9Y6G9,Q6Y7W6,P43246,P15927 7 +Regulation of myelination 0.4474973299251839 0.5807024632509804 0.5614410012861062 1.0 0.8793932931636681 7 Q9UPY3 1 +Cellular response to peptide 0.2901657097409039 0.5806437481949114 0.5614805809007961 1.0 0.8793932931636681 57 Q9H1E3,O60343,Q9UQB8,P07741,P62993,P27695,P48506,Q9Y5X3,P43490,Q96A49,P40763,Q00535,P11802,Q06124 14 +Positive regulation of intracellular signal transduction 0.2634875274824795 0.5803547924276949 0.5616753846359677 1.0 0.8794765856251535 104 P14174,Q92734,Q99829,Q06124,Q15555,P29692,Q9UMX5,Q9Y6G9,P19474,Q99873,Q02952,Q13325,P61586,O14745,P61927,Q99584 16 +Gland morphogenesis 0.3852508354529578 0.5796834178073816 0.562128127726905 1.0 0.8796618007774984 12 P15311,P26038,P07384,O14786,Q07812,P60953,Q15418,O14745 8 +Dopamine receptor signaling pathway 0.4471711354667907 0.5793690623261986 0.5623401746879271 1.0 0.8796618007774984 7 O14745 1 +Negative regulation of viral life cycle 0.6506764567534153 0.5793392571098801 0.5623602816564683 1.0 0.8796618007774984 3 Q14258 1 +Negative regulation of viral entry into host cell 0.6506764567534153 0.5793392571098801 0.5623602816564683 1.0 0.8796618007774984 3 Q14258 1 +Negative regulation of axonogenesis 0.4910601518871401 0.5782979460779011 0.5630629808682128 1.0 0.8803175003000003 5 Q8N0X7,O14786,Q00535 3 +Golgi to plasma membrane transport 0.3673498376800906 0.5754425077660642 0.564992062684649 1.0 0.8812313285357326 16 Q8TAG9 1 +Endoplasmic reticulum organization 0.3246141965658911 0.5743865330187382 0.5657062639549792 1.0 0.8817333870793738 29 Q5JRA6,Q15042,Q8NFQ8 3 +Positive regulation of cell morphogenesis involved in differentiation 0.3544652541427768 0.5729803720422666 0.5666579838832906 1.0 0.8821624667624053 18 Q9UQB8,O14786,O15144,P50570,Q92766 5 +Regulation of cell cycle phase transition 0.268456021006024 0.5725178000053784 0.5669712303091521 1.0 0.8822531605513768 97 Q9NYL9,P51530,P04083,O43660,Q9NXR7,Q9Y6G9,Q9UJX4,Q08J23,Q7L2J0,Q04637,Q92547,P43246,Q06124,Q15645,Q9NQW6,P54652,Q9P258,Q6Y7W6,Q5TBB1,P27695,Q9BXW9,Q9UJX2,P11802,Q8N6R0,P15927 25 +Lung epithelium development 0.4597496111073011 0.5720552863656013 0.5672845201419723 1.0 0.8822531605513768 6 Q13247,P09960,Q13155 3 +Positive regulation of ubiquitin protein ligase activity 0.6480160615481313 0.5707416449793622 0.5681747847579088 1.0 0.8832466314253986 3 Q16763 1 +Positive regulation of oligodendrocyte differentiation 0.539316380342762 0.5706929824114008 0.5682077765772089 1.0 0.8832466314253986 4 O14744 1 +Negative regulation of cellular component organization 0.2608911085654465 0.56928688798177 0.5691614636108466 1.0 0.8838826018270776 132 P02656,Q9NYL9,Q9H3K2,Q9UHV9,Q9Y624,P41227,P48506,P16949,Q9Y6G9,Q99471,P61586,P61758,Q15645,O60343,P35241,Q9NRR5,P54652,Q9NR77,O15212,Q02790,P25685,Q9NQ88,Q9P258,Q96G23,Q9NUQ9,Q15691,Q8N0X7,P17931,Q00535,O95104 30 +Regulation of phospholipase activity 0.4438286619952236 0.5657531087911675 0.5715616267527728 1.0 0.8861470949762987 7 P04083 1 +Microtubule bundle formation 0.3855138805218198 0.5655631265405149 0.5716908000307908 1.0 0.8861470949762987 11 Q15691 1 +Protein acylation 0.2976532483062545 0.5642984417103312 0.5725510417602986 1.0 0.8866940658989674 45 Q13363,Q5VZE5,P61964,P41227,Q86UY6,Q15014 6 +Regulation of map kinase activity 0.3850051573038109 0.5631508592496074 0.5733321616685063 1.0 0.8872147331077558 11 Q99816,P14174 2 +Histone modification 0.2518510413661093 0.5621112335801456 0.5740402350705451 1.0 0.8877644865633806 115 Q13363,P61964,Q9H4L7,Q9Y2K7,Q8NB78,Q9ULX6,Q9NW82,Q9H3P2,O14744,Q9H7B4,Q6PD62,Q86UY6,O15047,Q01105,Q15014 15 +Histone h4 k16 acetylation 0.4240876807249348 0.5619995983569515 0.5741162927598287 1.0 0.8877644865633806 8 P61964 1 +Microtubule based transport 0.3087524770683547 0.5610107303925723 0.5747902221972585 1.0 0.8881767628362913 37 Q13409,Q9BW83,P04792,O14745 4 +Regulation of body fluid levels 0.3109979889853765 0.5606493958957168 0.5750365707901555 1.0 0.8881767628362913 36 P35579,Q9UNS2,Q9Y624,P04792,P07741,P17612,P49257,P12814,P16949,P11172,P18206,P38435,Q13310,Q15149,Q9Y490,P61201,O75592,P53621 18 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.6448116414817812 0.5604406060293753 0.5751789411199439 1.0 0.8881767628362913 3 O95861 1 +Synaptonemal complex organization 0.4567705066741934 0.5603495247279695 0.5752410531606382 1.0 0.8881767628362913 6 P54652,Q15645 2 +Extracellular vesicle biogenesis 0.423469128610991 0.5593886669572885 0.5758964941762537 1.0 0.888674366113264 8 Q99816,O43633,Q9UN37,Q92905 4 +Hemidesmosome assembly 0.6444393483530619 0.5592477564857578 0.5759926447030415 1.0 0.888674366113264 3 P11047 1 +Dna strand elongation involved in dna replication 0.4046583434390469 0.5588144459680153 0.5762883624251931 1.0 0.8887856128154905 9 P33991,P51530,Q07864,P33993,P09884 5 +Renal water homeostasis 0.6508585445625574 0.5581571157391082 0.57673710167111 1.0 0.8891374112096524 2 P17612 1 +G protein coupled receptor signaling pathway 0.3197417244700429 0.5579691069202073 0.5768654798331223 1.0 0.8891374112096524 31 Q99720,P02656,P04083,P0DP25,Q02952,O14745,O14744 7 +Localization within membrane 0.2541590758839683 0.5570915728338469 0.5774648649860838 1.0 0.8893990108044596 120 Q9NT62,Q9NPA0,Q9Y624,O76094,Q15904,Q9ULT8,P42566,Q8TAG9,P35241,Q8IWJ2,P35609,P15311,P41440,Q9H4M9,P35613,O14737,Q9H223,Q15042,O14745,P50570,Q9UN37,O00471,P49354,P17931,P0DP25,Q00535,Q9UHB9,Q15436 28 +Cellular response to extracellular stimulus 0.3078583079829188 0.5539407566201623 0.5796193910845058 1.0 0.8916116964663813 37 Q9H773 1 +Glial cell differentiation 0.3141230282561101 0.5531943570018927 0.5801303306159244 1.0 0.8917201524130517 34 Q06124,Q9UI10,P11047,Q9NR50,P40763,O14744,P61586,Q9UPY3 8 +Interferon beta production 0.3932077505392399 0.5527089621838162 0.5804627154675708 1.0 0.8917201524130517 10 P41440 1 +Positive regulation of interferon beta production 0.3932077505392399 0.5527089621838162 0.5804627154675708 1.0 0.8917201524130517 10 P41440 1 +Lymphocyte costimulation 0.6492232215862699 0.5525793847826921 0.5805514615468548 1.0 0.8917201524130517 2 Q06124 1 +Keratinocyte differentiation 0.3500080644603482 0.5477361754472532 0.5838730687433555 1.0 0.893905884664827 18 Q13247,P04083 2 +Regulation of receptor signaling pathway via stat 0.4825215361191849 0.5463136859499512 0.5848503302054928 1.0 0.8950025999448277 5 Q6IA86,Q00535,P30153 3 +Golgi organization 0.3163545015192925 0.5442206121702388 0.5862896693498327 1.0 0.8959216874756313 32 Q14789,P50570,Q7Z460,P06493,Q7Z6Z7,Q92538,Q9UNZ2,P40616,P49257,P83436,Q9BVK6,Q8IWJ2,P63104,P60953,O43264,O14744,O60763 17 +Keratinocyte development 0.6396584265373477 0.5440037570974218 0.5864388874319821 1.0 0.8959216874756313 3 Q8WX93 1 +Regulation of transferase activity 0.2562130386375219 0.5433885680736202 0.5868622950936011 1.0 0.8963145234951458 126 P04792,Q16763,Q9H7B4,P61586,P23381,P14174,Q9Y376,Q13526,Q9BRT9,P61927,Q99816,Q96A49,O14745,Q9NQ88,Q9NYV4,Q99627,Q96B36,O95684,P0DP25,Q00535 20 +Response to ether 0.6392638036809752 0.5427517483971891 0.587300739301629 1.0 0.8963659941505103 3 P11802,Q6PKG0 2 +Regulation of hormone secretion 0.3326513657062195 0.5422915043163106 0.5876177072764457 1.0 0.8963659941505103 22 O43768,P30626,P04083,O95563,Q06124 5 +Negative regulation of mapk cascade 0.3323369632007187 0.5403381543620949 0.5889638503037766 1.0 0.8967328373738734 22 P51452,P15311,P31689,Q96S59,P56537,Q13526,O14745,Q96J02,P30153 9 +Regulation of adaptive immune response 0.3420469282525957 0.5401751258700981 0.589076265037412 1.0 0.8967328373738734 19 Q9NUQ9,P04083 2 +Myoblast fusion 0.4374519892502848 0.5400248629008824 0.589179886194916 1.0 0.8967328373738734 7 P17655,P41440,Q9H4M9 3 +Syncytium formation 0.4374519892502848 0.5400248629008824 0.589179886194916 1.0 0.8967328373738734 7 P17655,P41440,Q9H4M9 3 +Positive regulation of lipid kinase activity 0.6382871444678107 0.5396572886510201 0.5894334003825608 1.0 0.8967328373738734 3 Q99570 1 +Positive regulation of mitotic nuclear division 0.4187636751464899 0.5396381392023217 0.5894466090435027 1.0 0.8967328373738734 8 Q9UJX2,Q9UJX4 2 +Positive regulation of nuclear division 0.4187636751464899 0.5396381392023217 0.5894466090435027 1.0 0.8967328373738734 8 Q9UJX2,Q9UJX4 2 +Positive regulation of cell cycle 0.2720769101171011 0.5385333224587361 0.5902089063579086 1.0 0.8976191293287175 75 Q9NYL9,O43660,P04083,Q9Y6G9,P19474,Q9UJX4,Q7L2J0,Q04637,P61586,Q06124,P51452,P31350,P30260,P35241,P54652,P06730,P14635,P43487,Q9UNZ2,P39748,Q6ZWJ1,P78362,Q9P258,P27695,Q9UJX2,P11802 26 +Regulation of lymphocyte apoptotic process 0.4511118389045593 0.5383027293316996 0.5903680673888885 1.0 0.8976191293287175 6 P17931,P14174 2 +Embryo development ending in birth or egg hatching 0.2626201016776943 0.5365244343854563 0.5915961534191947 1.0 0.8989019116058721 101 O43772,Q9UNS2,Q7Z6E9,P67809,Q08J23,Q99873,Q12824,Q9ULT8,Q96AY3,P43246,P11233,P35579,O75340,P31350,P62993,Q6DKJ4,Q96EK5,Q9BRT9,O60568,Q6PD62,P61201,P49321,P14635,P16989,P20290,O95983,Q5TBB1,Q9NVX2,Q13263,P17655,O75312 31 +Cytoplasmic translation 0.2590882107680748 0.5353507929023001 0.5924073096025051 1.0 0.8996006330491481 105 Q9Y5A9,P16989,Q7L2H7,P56537,Q9NR50,P23588,P84098,Q04637,P61927,P55010,P05387 11 +Regulation of peptidyl tyrosine phosphorylation 0.3341332061252665 0.5347610227242003 0.5928151186961377 1.0 0.8998733529951148 20 Q9H2J4,P14174,O95684,Q9H223,Q06124 5 +Intracellular mrna localization 0.6434995911692625 0.5332131878013124 0.5938860135299107 1.0 0.9006183501882161 2 Q99729 1 +Negative regulation of locomotion 0.3073962757164963 0.5327418107191747 0.5942123191757638 1.0 0.9008931889847396 36 P14174,Q99439,Q13526,O14745,P61586,Q5JRA6,Q96G23 7 +Cellular response to exogenous dsrna 0.4354811096734049 0.5321415298299619 0.594627975703538 1.0 0.9011990822969608 7 P41440 1 +Microtubule organizing center organization 0.3228523790082206 0.5312033665470663 0.5952778603202658 1.0 0.9016281738021584 26 P52732,Q8TEY7,O43633,Q9UNZ2,Q14203,Q8IWJ2 6 +Regulation of cation channel activity 0.3677941314139283 0.5305110030694846 0.5957576822388044 1.0 0.9017343515169158 14 P27695,P30626,P07384,P0DP25,Q00535,P28161 6 +Negative regulation of apoptotic signaling pathway 0.287061372026169 0.530234966762418 0.5959490301504307 1.0 0.9017343515169158 55 P16989,P14174,P04792 3 +Chromatin disassembly 0.3714881348723481 0.5298162423784071 0.5962393426652659 1.0 0.9017343515169158 13 Q01105,P17096,Q12824 3 +Protein localization to endosome 0.4163116691510694 0.5294265042863864 0.5965096161081305 1.0 0.9017343515169158 8 O14786,P15311,P35241,Q96QK1 4 +Multicellular organism reproduction 0.2641839461655533 0.5283994997630057 0.5972220846420344 1.0 0.9025045892008678 98 Q15645,Q06124,Q9Y5A9,P16989,Q6P6C2,Q9BQE5,Q9BW83,Q8NB78,P04083,P35613,Q9BXW9,P43246,P54727,P54652,Q14353,O75592,O60684 17 +Positive regulation of lamellipodium organization 0.3876896546378476 0.5277861247626654 0.5976477885793519 1.0 0.9025045892008678 10 Q92766,O15144,P60953,P50570 4 +Post translational protein modification 0.4152356720476897 0.5249633179165821 0.5996086913395207 1.0 0.9025045892008678 8 Q8TBC4,P61081 2 +Cell cell junction assembly 0.3280493742611662 0.5240156622524883 0.6002676463220444 1.0 0.9025045892008678 23 P17612,Q9Y624,Q8WUM4,Q9BTW9,Q13177,P18206,Q9Y490,P61586 8 +Immune response regulating cell surface receptor signaling pathway 0.3322652347248385 0.5235987215553776 0.6005576708949292 1.0 0.9025045892008678 20 P51452,P15311,P46379,Q9UI10,Q9NR50,P17931,Q07812,Q07666 8 +Negative regulation of peptidyl tyrosine phosphorylation 0.446917608127495 0.5221275309939738 0.6015815389195742 1.0 0.9025045892008678 6 Q99816,O95684 2 +Leukotriene biosynthetic process 0.525215975682697 0.5215997369371564 0.6019490465113726 1.0 0.9025045892008678 4 P09960 1 +Dna templated transcription termination 0.4323681533755886 0.5197587959942117 0.6032317012159116 1.0 0.9031363559598234 7 Q16637,O14744 2 +Transport along microtubule 0.3056641249046093 0.5194291985465789 0.6034614741865432 1.0 0.9031363559598234 36 P04792 1 +Protein localization to golgi apparatus 0.4321161929950419 0.5187603019319933 0.6039279044241335 1.0 0.903273672079448 7 P40616,P83436 2 +Regulation of chromosome separation 0.3287291840467753 0.5180473317789532 0.6044252459334705 1.0 0.9034726477266538 22 P14635,Q15645,P30260,P12270,Q9Y6G9,Q9UJX4,Q9UJX2,P06400,O43264,O43683,O43684 11 +Secretory granule localization 0.6313552135574283 0.5178677463723623 0.604550547020557 1.0 0.9034726477266538 3 P33176 1 +Rna phosphodiester bond hydrolysis endonucleolytic 0.3173970699844528 0.517100300784546 0.6050861436676229 1.0 0.9037000846983978 28 Q9UQ84 1 +Regulation of phosphorus metabolic process 0.2726031245095343 0.5160549273793569 0.6058160467959393 1.0 0.9044609468042458 177 P04792,O75874,Q9H7B4,Q04637,P61586,P23381,Q06124,P14174,Q9Y376,P56537,Q13526,Q15257,P54652,P41440,Q99816,Q9H223,Q96A49,O14745,Q9NQ88,Q9NYV4,Q99627,Q96B36,Q9H2J4,Q13148,O95684,Q9ULX6,P40763,P0DP25,P17931,Q00535 30 +Positive regulation of response to external stimulus 0.2917184456776142 0.5159535062936017 0.6058868822392371 1.0 0.9044609468042458 46 P04792 1 +Phagocytosis 0.318005300460176 0.5157273335063907 0.6060448612575511 1.0 0.9044793531385226 27 Q9NT62,Q99439,P04083 3 +Skeletal system development 0.302445807417611 0.5115529302326698 0.6089639352495193 1.0 0.9066240847383944 37 Q15904,P61586 2 +Regulation of tor signaling 0.4117949586022157 0.5107666327530528 0.6095144763759797 1.0 0.9066240847383944 8 Q96B36 1 +Regulation of systemic arterial blood pressure 0.4728520337911263 0.5107503861577258 0.6095258540713038 1.0 0.9066240847383944 5 P61586 1 +Hypothalamus development 0.472106424939155 0.508038895476922 0.6114260661890034 1.0 0.9085537226690572 5 Q07812,Q15042,P27695 3 +Positive regulation of protein dephosphorylation 0.3702272609257448 0.507668686675513 0.611685711907636 1.0 0.9085537226690572 12 Q13526,Q15257 2 +Axon development 0.2785850238893928 0.5065408785322226 0.6124770001545106 1.0 0.9092713772315348 60 Q9UQB8,P00374,P78344,P16949,O14786,P33176,Q06124,Q8TEY7,Q8WX93,Q99707,O95372,P41440,P35613,P50570,O75592,Q96G23,P11047,Q8N0X7,Q00535,O75312 20 +Positive regulation of organ growth 0.4426906095053173 0.5059759321834291 0.6128735455875451 1.0 0.9096426190484358 6 P16989 1 +Protein transmembrane import into intracellular organelle 0.3826519544907965 0.5053255388753014 0.6133302080712719 1.0 0.9099713998658524 10 O60830 1 +Positive chemotaxis 0.4424376839865711 0.5050144025659666 0.6135487201743208 1.0 0.9099713998658524 6 O14786,P17931,P14174 3 +Protein containing complex organization 0.235588728077296 0.5019698694510039 0.6156887157348703 1.0 0.9116428943642204 448 P02656,Q8WXF0,Q9H7B4,P61586,Q9NXV2,Q8N511,P14174,P34896,Q99590,Q9NRR5,Q9UPY3,P55010,Q5TC12,Q99720,Q13247,Q9UBW8,O95831,Q9NWX6,P17096,P35637,Q15691,O43633,Q92734,Q9H7B2,Q9UQB8,Q15428,Q14019,P04179,Q16637,Q01105,O75340,Q13526,P23588,Q02790,Q9Y281,Q92688,Q9H223,O14745,Q6DKK2,Q99627,Q9NUQ9,P11047,Q9NZW5,O14744,Q96AX1,Q9Y312,Q16763,Q14203,Q15637,Q99873,Q99733,Q04637,P61758,P23381,Q06124,P62993,P56537,Q9NQW6,Q12872,O15212,P49321,Q8N543,Q9H4M9,Q99816,Q7Z478,Q9Y490,Q9Y5K6,Q15813,Q8N684,P17931,P46777,O95104,Q92747,Q9NYL9,P16949,O15143,Q12824,Q8WXX5,P42566 79 +Nephron epithelium development 0.4088707266344005 0.4987935479904335 0.6179248333594745 1.0 0.9124141172789412 8 P80723 1 +Negative regulation of response to stimulus 0.2726186947457982 0.497507647451912 0.6188311113996883 1.0 0.9127613315733224 183 Q9H3K2,P04792,Q9UJ14,P04179,P04083,P19474,Q99471,P61586,O75340,Q86WB0,P14174,P56537,Q9Y5X3,Q13526,Q9NRR5,P28070,Q9Y2U8,P16989,O14745,Q96G23,Q96B36,Q9NUQ9,Q99829,Q9Y5A9,Q9UMX5,P80303,Q04323,Q96J02 28 +Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 0.6324611610793203 0.4965795418796115 0.6194855828360026 1.0 0.9127613315733224 2 Q07812 1 +Positive regulation of signal transduction by p53 class mediator 0.3901400815598922 0.4959729138009643 0.6199135213264702 1.0 0.9128913842630731 9 P61927 1 +Mitotic g1 s transition checkpoint signaling 0.4399496634076604 0.495586114780211 0.6201864512880206 1.0 0.9130767810570432 6 Q6Y7W6 1 +Mitotic intra s dna damage checkpoint signaling 0.4682052780225642 0.4939269924838035 0.6213577407690849 1.0 0.9133522734926912 5 Q9BXW9 1 +Synaptic vesicle recycling 0.3603574675969997 0.4937968747574649 0.6214496405338763 1.0 0.9133522734926912 14 P20339,P0DP25,Q00535 3 +Mitochondrial ribosome assembly 0.6234458806534874 0.493391864836954 0.6217357294056831 1.0 0.9133522734926912 3 Q567V2 1 +Leukocyte proliferation 0.3118386032485741 0.4928781522908262 0.6220986853389499 1.0 0.9133522734926912 30 P14174,P04083 2 +Regulation of apoptotic process involved in development 0.6304170073589603 0.4899035240993002 0.6242021691825861 1.0 0.9150839165778704 2 Q07812 1 +Lamellipodium organization 0.3330248676744057 0.4885019595602567 0.6251943380710974 1.0 0.9158897946264484 19 P50570,Q14247,O60749,P18206,O15144,P60953,Q92766 7 +Regulation of phosphatidylinositol 3 kinase activity 0.6216768916155335 0.4879761032803023 0.6255667676261774 1.0 0.9160032131475032 3 Q99570,P60953 2 +Membrane invagination 0.3785305711415599 0.4871702077184503 0.6261377161153558 1.0 0.9162304472094026 10 P61586 1 +Positive regulation of actin filament depolymerization 0.5150620930776717 0.4871323024770832 0.6261645761604999 1.0 0.9162304472094026 4 Q9Y281 1 +Positive regulation of protein depolymerization 0.5150620930776717 0.4871323024770832 0.6261645761604999 1.0 0.9162304472094026 4 Q9Y281 1 +Ribonucleoprotein complex disassembly 0.5149984644349501 0.4869188131582079 0.6263158661570045 1.0 0.9162359314098936 4 P33176 1 +Regulation of phagocytosis 0.3654807425603886 0.4854922228529292 0.6273272280939097 1.0 0.9170673461542324 12 Q99439 1 +Synaptic transmission dopaminergic 0.4657394819908267 0.4850737012698118 0.6276240663286676 1.0 0.9171685613844252 5 P41440 1 +Negative regulation of protein localization to cell surface 0.6287816843826728 0.4845878200265799 0.627968755288663 1.0 0.9171685613844252 2 P35609 1 +Signal release 0.2888757609776774 0.4845617752850243 0.6279872339785146 1.0 0.9171685613844252 41 P14174,O43768,P20339,P04083,O95563,P0DP25,Q15042,Q00535,Q06124 9 +Regulation of histone ubiquitination 0.3769520018934681 0.4802709427650318 0.6310347476294202 1.0 0.9192363683395568 10 Q6PD62 1 +Stem cell differentiation 0.2910621555965874 0.4800072826232651 0.631222214622569 1.0 0.9192363683395568 40 O75340,Q9Y5A9,Q9UBV8,Q8WX92,O14786,Q08J23,O15047,P40763,Q9NYV4,O00231,Q96J02 11 +Astral microtubule organization 0.5126499088225644 0.47906136178096 0.6318949761504375 1.0 0.9192363683395568 4 P15311,Q14974 2 +Cytoskeleton organization 0.2742942356717739 0.4789133324972899 0.632000285723167 1.0 0.9192363683395568 240 Q9Y2I1,P04083,O14786,O15144,P61586,P08670,P11233,P35579,Q99439,Q14247,Q96HC4,Q15257,P59998,O43237,P14635,P60953,P35580,Q9H2J4,Q8N3U4,Q15942,Q15691,Q13177,P30153,O43633,P29966,Q15018,Q9UQB8,Q16555,Q86Y56,Q14019,Q9P287,Q9Y3A5,Q15149,O43264,Q8WX93,P10644,Q8WUM4,Q13526,Q9Y696,Q14974,Q02790,P06493,Q9Y281,Q9UNZ2,P26038,P12814,Q16204,P68371,O14745,O75592,Q7Z460,Q8NI77,Q9NUQ9,O95684,Q14203,Q9Y6G9,Q8TEY7,Q15555,Q01518,P62993,Q9NQW6,P52732,P52565,Q9BUF5,Q9Y490,Q9Y5K6,Q15813,Q00535,P17655,P07197,O75312,Q92747,Q9NYL9,Q9UHV9,Q9Y624,P16949,O15143,P35241,Q8IWJ2,O00151,P35609,P15311,P43487,Q05682,Q9BTW9,Q9Y266,Q96S59,Q9UN37,P04406 89 +Endoplasmic reticulum to golgi vesicle mediated transport 0.286972914925539 0.4786462752675861 0.6321902918985511 1.0 0.9192363683395568 47 O75340,Q92734,Q9BVK6,Q15436,Q5JRA6 5 +Cytoskeleton dependent intracellular transport 0.2880649369049523 0.4780632158144248 0.6326052120785046 1.0 0.9192363683395568 42 P04792 1 +Stress fiber assembly 0.3244721803152943 0.4777007511129565 0.6328632096423366 1.0 0.9192363683395568 20 Q9Y624,Q15942,P16949,O14786,P60953,P61586,O00151 7 +Response to radiation 0.2644447337620194 0.4771207749174146 0.6332761219245806 1.0 0.9192363683395568 67 Q9H1E3,Q9UNS2,Q15555,P62993,P29692,P04179,P04083,P09884,Q9NXR7,Q9BXW9,Q07812,Q00535,Q14011,P50570,Q9NQ88,P05198,Q92547,P43246 18 +Positive regulation of peptidyl serine phosphorylation 0.3603243134908295 0.4762735883869124 0.6338794791398141 1.0 0.9192363683395568 13 Q9H7B4 1 +Chromatin assembly or disassembly 0.2660175862822151 0.4749097729168038 0.6348512853452317 1.0 0.9192363683395568 66 Q13363,P49321,Q8TEX9,P17096,Q92688,Q08945,Q12824,Q99733,Q9H7B4,Q6PD62,O95983,Q8WXX5,Q01105 13 +Vitamin transmembrane transport 0.4625834186291971 0.4738192513535639 0.6356288051553121 1.0 0.9192363683395568 5 P38435,P41440 2 +Vitamin transport 0.4625834186291971 0.4738192513535639 0.6356288051553121 1.0 0.9192363683395568 5 P38435,P41440 2 +Regulation of muscle contraction 0.3478498653037201 0.4736125549472593 0.6357762208348279 1.0 0.9192363683395568 16 P28161,P61586 2 +Nucleotide transmembrane transport 0.4201776625874803 0.4721285835361102 0.6368350112812684 1.0 0.9192750089398676 7 O43808,P41440,Q9H2D1 3 +Negative regulation of histone methylation 0.4022660282724501 0.4720786069707144 0.6368706817074936 1.0 0.9192750089398676 8 P61964 1 +Myotube differentiation 0.3517957492433042 0.4714641146405455 0.637309340105801 1.0 0.9192750089398676 15 Q9H7B4 1 +Positive regulation of myeloid leukocyte differentiation 0.6246933769419531 0.4713978840202052 0.637356626752865 1.0 0.9192750089398676 2 P06400 1 +Negative regulation of peptidyl serine phosphorylation 0.616199197493198 0.4713463660344278 0.6373934100475098 1.0 0.9192750089398676 3 Q07812 1 +Regulation of cell division 0.3195351969909916 0.4713046174350025 0.6374232187592705 1.0 0.9192750089398676 23 Q13526,P61586,P61964 3 +Cell junction organization 0.26367477914573 0.4674852833816183 0.6401527187520137 1.0 0.921831572277565 89 Q9UQB8,Q9Y624,Q14203,O14786,Q15149,O95793,P61586,Q04637,P51452,Q15555,Q14247,Q8WUM4,P20810,P35241,Q9UDY2,Q96HC4,Q13526,Q96QK1,P35609,P18085,P17612,P41440,Q9BTW9,P12814,Q13112,P63104,P60953,Q9Y490,Q9P258,O60678,P11047,Q13177,P49354,P18206,Q00535 35 +Regulation of stress granule assembly 0.6234668847097375 0.4674689896736442 0.6401643735766971 1.0 0.921831572277565 2 Q9UN86 1 +Cellular response to interleukin 1 0.3833236557952725 0.4672673755540774 0.6403085947011504 1.0 0.921831572277565 9 Q02952,Q92900 2 +Positive regulation of dephosphorylation 0.3581608168595438 0.4660972722251347 0.6411458757089186 1.0 0.921831572277565 13 Q13526,Q15257 2 +Positive regulation of cell death 0.2643738493730336 0.4650886143970338 0.6418679991264846 1.0 0.921831572277565 86 P04179,P04083,P98175,Q04637,P61586,P61081,Q15257,O43324,Q96A26,O95831,O14737,Q02952,O14745,Q9NQ88,P05198,P50570,O00273,Q7Z7L1,Q9NR28,Q00535,P17655 21 +Negative regulation of cell cycle g1 s phase transition 0.3733100104503614 0.4644727030476007 0.6423091121556288 1.0 0.921831572277565 10 Q6Y7W6,Q8N6R0,P15927 3 +Adherens junction organization 0.3607991976133698 0.4639180514175476 0.6427064592477754 1.0 0.921831572277565 12 Q9BTW9,P35241,Q13177,P18206,P60953 5 +Positive regulation of substrate adhesion dependent cell spreading 0.3607233863438772 0.4635712192466982 0.6429549784476114 1.0 0.921831572277565 12 Q92766,O14786,O15144,P50570 4 +Response to toxic substance 0.2861784639889989 0.4632073946704506 0.6432157163340542 1.0 0.921831572277565 43 O95831,P34913,P28161 3 +Cell fate commitment 0.3283231889195411 0.4621421291233015 0.6439794002871759 1.0 0.921831572277565 19 P61586 1 +Peptide transport 0.3161754766054109 0.4611181701999386 0.6447138261877357 1.0 0.9222585485892963 24 O43768,P30626,P04083,O95563,O14745,Q06124 6 +Cellular response to oxygen containing compound 0.2637798065615418 0.4609444990227327 0.6448384247946417 1.0 0.9222585485892963 159 Q9UQB8,P48506,P04179,P04083,P00374,P43490,Q12824,Q9H7B4,P61586,Q06124,P14174,O60343,P07741,P62993,P30626,P34896,Q99707,Q9Y5X3,O95563,Q6PD62,P35609,Q99720,Q9H1E3,P15311,Q92900,O95831,Q96A49,O14745,P17655,P27695,P40763,Q00535,O14744,P11802 34 +Male gamete generation 0.2723451454014768 0.4601094717233898 0.6454376458019271 1.0 0.9226042575718754 61 Q96PU8,Q08J23,O95470,Q15645,Q96EP5,O95394,Q9BW83,P54727,P54652,O75718,P54619,Q14353,P16989,P52701,P50570,Q9Y5A9,Q6P6C2,Q07812,Q07666 19 +Dsrna processing 0.3533630528926543 0.4599865909672379 0.6455258452737196 1.0 0.9226042575718754 14 Q9UPY3,P40763 2 +Nucleoside monophosphate catabolic process 0.5059810758875474 0.4569945089870369 0.6476749922755345 1.0 0.923758864267792 4 P00491,O43598 2 +Glial cell apoptotic process 0.5057634163951871 0.4562805309834263 0.6481882621987016 1.0 0.9238579546141696 4 Q02952 1 +Positive regulation of cell cycle phase transition 0.285314234632842 0.4554510820101802 0.6487847527496238 1.0 0.9242404602869234 41 Q9NYL9,P11802,P27695,O43660,P04083,Q9UJX4,Q9UJX2,Q7L2J0,P54652,Q04637,Q9P258 11 +Positive regulation of lipid localization 0.380005864579073 0.4534971841864928 0.6501907704939209 1.0 0.9247247852097604 9 O60664,P14174 2 +Positive regulation of protein kinase activity 0.2948506790393453 0.4533655632317285 0.6502855293093437 1.0 0.9247247852097604 37 Q99627,P14174,Q9Y376,Q96A49,P0DP25,P61586 6 +Regulation of myeloid cell differentiation 0.3128503748073594 0.4521989927035426 0.651125633783129 1.0 0.9251502794124128 25 Q96T37,P56537,P40763,Q99873,Q6PD62,O15347 6 +Rhythmic process 0.2828487025877698 0.4514921074870681 0.6516349121363554 1.0 0.9253339195399194 49 P43490,O75592,Q9Y2K7,P04083 4 +Deoxyribonucleoside monophosphate catabolic process 0.6181520850368021 0.4505969834505173 0.6522800411556848 1.0 0.9258649269889836 2 P00491 1 +Regulation of histone modification 0.2831191182317315 0.4496075306773283 0.6529934571053073 1.0 0.9264543305571508 48 Q13363,P61964,Q9ULX6,Q9NW82,Q6PD62,Q01105 6 +Chromosome separation 0.3080346316473467 0.4496072546440945 0.6529936561753058 1.0 0.9264543305571508 27 Q9UJX2,Q9Y6G9,Q9UJX4,Q9H4L7 4 +Potassium ion transport 0.3468729585769789 0.4473467468942547 0.6546247194587445 1.0 0.928321252466488 15 Q9Y376,P35609,P55011,P50570 4 +Nik nf kappab signaling 0.3418763582289618 0.4435943955491554 0.6573358584295748 1.0 0.9300150819001076 16 Q99627,P61586,Q9UPY3 3 +Regulation of muscle cell differentiation 0.3460996087706864 0.4435942090474231 0.657335993292814 1.0 0.9300150819001076 15 P04179,Q15014 2 +Mitochondrial dna replication 0.4530679855864264 0.4404355990984692 0.6596216463067204 1.0 0.9308488086134934 5 P51530 1 +Erk1 and erk2 cascade 0.3051388507998253 0.440428818307876 0.6596265564940018 1.0 0.9308488086134934 29 P15311,P14174,Q96S59,P56537,Q13526,O14786,Q02952,O14745,O14744,Q06124 10 +Regulation of ubiquitin protein transferase activity 0.3303333260612148 0.4400765662914315 0.6598816536054528 1.0 0.9308488086134934 18 Q13526,Q16763,P61927,P46777 4 +Regulation of fibroblast migration 0.4245819894913175 0.4386404915208219 0.6609220524640302 1.0 0.9315310816617404 6 Q02952 1 +Protein k63 linked deubiquitination 0.3937633583916047 0.4383976471966114 0.6610980517178218 1.0 0.9315677107255896 8 Q9NXR7 1 +Synaptic vesicle cytoskeletal transport 0.5001399292641538 0.4379753511605969 0.6614041516157703 1.0 0.9316012239962768 4 Q9Y2T2 1 +Non lytic viral release 0.4522544726108434 0.4376211699755064 0.6616609223466869 1.0 0.9316012239962768 5 O43633 1 +Dna templated transcription elongation 0.3025142586094431 0.436767448158916 0.6622800085900364 1.0 0.9316012239962768 31 Q15061,Q5BKZ1,Q8WX92,Q9H3P2,Q6PD62,Q9NYV4,P43897 7 +Inositol lipid mediated signaling 0.3933364825655627 0.4367288950342132 0.6623079712855051 1.0 0.9316012239962768 8 Q9UBF8,O14745 2 +Neutrophil chemotaxis 0.3754888621945329 0.4349731334783059 0.6635819287736382 1.0 0.9319129005628316 9 P35613 1 +Regulation of cell development 0.2709956683228263 0.4349565260669485 0.6635939835445614 1.0 0.9319129005628316 60 Q9UQB8,Q9Y624,P78344,O14786,O15144,O94874,Q04917,Q9UPY3,P60953,P50570,Q9P258,Q92766,Q96G23,Q9Y5A9,P27695,Q8N0X7,P18206,Q00535,O14744,P39019 20 +Protein dna complex disassembly 0.3512548468549576 0.4340842968289785 0.6642272282352366 1.0 0.9319129005628316 13 Q01105,P17096,Q12824 3 +Establishment of spindle orientation 0.3926401705188279 0.4340115528483235 0.6642800517268739 1.0 0.9319129005628316 8 Q9UNZ2 1 +Negative regulation of metaphase anaphase transition of cell cycle 0.3512078808197615 0.4338691208463034 0.6643834844357746 1.0 0.9319129005628316 13 P14635,Q15645,P12270,Q9Y6G9,O43264,O43683,O43684 7 +Negative regulation of nuclear division 0.3512078808197615 0.4338691208463034 0.6643834844357746 1.0 0.9319129005628316 13 P14635,Q15645,P12270,Q9Y6G9,O43264,O43683,O43684 7 +Ribonucleoside diphosphate metabolic process 0.2961313864028048 0.4337792004773644 0.6644487870085616 1.0 0.9319129005628316 35 P30085,P31350,Q05682,P00338,P56537,Q9UDY2,P04406,P11172,P17858,P40763,P18669,Q9NQ88,P54619,P36871 14 +Fibroblast growth factor receptor signaling pathway 0.4227647993357649 0.4320627069369738 0.6656958383554497 1.0 0.9319141470214928 6 Q06124 1 +Regulation of b cell activation 0.350588264337476 0.4310336337425035 0.6664439150942887 1.0 0.9325409447353612 13 P14174,O15347 2 +Negative regulation of calcium ion transmembrane transport 0.4088598001260255 0.4292494494054767 0.6677417001695565 1.0 0.9335471724502338 7 P28161,P0DP25 2 +Regulation of cytoplasmic transport 0.3739237392373997 0.4286166200002131 0.6682022484729135 1.0 0.9335471724502338 9 P27361,P15311,O60493,Q02750,P26038,P35241,Q93009,P28482 8 +Negative regulation of blood pressure 0.4970851486377322 0.4281481887527356 0.6685432347516946 1.0 0.9336548103980646 4 Q9HB40,P04179 2 +Regulation of early endosome to late endosome transport 0.3910949620201727 0.4280023824410093 0.6686493858495413 1.0 0.9336548103980646 8 P15311,P35241,P26038 3 +Regulation of mitotic nuclear division 0.3044224916530255 0.4262313174159826 0.6699392994160762 1.0 0.9344840632016695 27 Q13526,Q9Y6G9,Q9UJX2,Q9UJX4,O14744 5 +Regulation of gene expression epigenetic 0.2949518832369565 0.4252681114491017 0.6706412369909724 1.0 0.9350003116099096 35 Q13363,Q6PD62 2 +Skin development 0.2965997282990169 0.4249276442550902 0.6708894217127925 1.0 0.9350003116099096 34 Q13247,Q15392,P04083 3 +Regulation of nuclear division 0.3034994362430683 0.4243781461989273 0.6712900559292878 1.0 0.9353177579809012 28 Q13526,Q9Y6G9,Q9UJX2,Q9UJX4,O14744 5 +Embryonic body morphogenesis 0.6095666394112912 0.4238847328648669 0.6716498788878145 1.0 0.9353993603707844 2 Q7Z460 1 +Epidermal cell differentiation 0.3060180319823437 0.4222000659949375 0.6728789933434924 1.0 0.9354761138775892 26 Q13247,Q8WX93,P04083 3 +Protein localization to cell surface 0.3722837228372354 0.421991045873361 0.6730315531723527 1.0 0.9354761138775892 9 P21333,Q92538,O00203,Q13492,P08238,P18206,P35222,P35609 8 +Negative regulation of mitotic cell cycle 0.2806920414837916 0.4209809650356132 0.673768981595398 1.0 0.9356503472724244 45 Q6Y7W6,Q9BXW9,Q9NXR7,Q9Y6G9,O14745,Q92547,P43246,P15927 8 +Nuclear envelope organization 0.3124350863222636 0.420534681613348 0.6740948990992595 1.0 0.9357709682495902 22 O43633,Q9Y2U8,Q9UNZ2,Q14203,Q9ULX6 5 +Regulation of sodium ion transmembrane transport 0.3714534246985524 0.4186505664728988 0.6754715281989656 1.0 0.9366477186820537 9 O14745,P50570 2 +Regulation of peptidyl serine phosphorylation 0.3367900384398402 0.4185276315116664 0.6755613884479996 1.0 0.9366477186820537 16 Q9H7B4 1 +L ascorbic acid metabolic process 0.5979550102249594 0.4175736983830664 0.6762588302066166 1.0 0.9371711107087036 3 P48506,P78417 2 +Positive regulation of hydrolase activity 0.2601092513657478 0.416107786090699 0.6773311327487843 1.0 0.9373443947884592 73 O75340,Q96A26,Q15555,O60343,P40616,Q9P258,Q92688,Q9NR28,Q13526,O95831,O14737,P49354,P40763,Q15042,P0DP25,Q15257,P61586,Q8TC07 18 +Positive regulation of helicase activity 0.4931161707898385 0.4155064163502102 0.6777712190365972 1.0 0.9373443947884592 4 P43246 1 +Vesicle transport along microtubule 0.3703899259583508 0.4143856499241701 0.6785916965777776 1.0 0.9381243178423864 9 Q92572,P33176,P27695,Q9Y2T2 4 +Dna packaging 0.259162936527556 0.4139484590242558 0.6789118535481284 1.0 0.9381492235277876 70 Q13363,Q8TEX9,P41227,Q92688,Q9ULX6,O95831,Q99733,Q9H7B4,Q6PD62,Q01105 10 +Regulation of endothelial cell development 0.4925559292889759 0.4137336729223885 0.6790691636596393 1.0 0.9381578434541402 4 Q9Y624 1 +Retrograde transport endosome to golgi 0.3096264859560456 0.4118884542991118 0.6804211837104839 1.0 0.9386535341571972 23 O60271,P49257,P40616,Q14203,Q9BVK6,O60749,Q8IWJ2,Q9P2R3,Q9Y5X3,Q13596 10 +Autophagosome maturation 0.348976791805758 0.4108685653450488 0.681168913376786 1.0 0.9388983565227016 12 Q96AX1,O43633,Q9NRR5 3 +Positive regulation of amino acid transport 0.5955683501440846 0.4107330686988262 0.6812682760855544 1.0 0.9388983565227016 3 Q15042 1 +Proteasome assembly 0.4162855427097524 0.4088969244541771 0.6826153061523714 1.0 0.9399622655904544 6 Q5VYK3,O00231,O95456 3 +T cell proliferation 0.3121473205305696 0.4075737131306193 0.6835866664237331 1.0 0.94089842433074 20 P04083 1 +Regulation of exit from mitosis 0.490518095180562 0.4073102614774824 0.6837801270538857 1.0 0.94089842433074 4 Q9UJX2 1 +Regulation of cyclase activity 0.443211092410838 0.4067782834991073 0.6841708380756986 1.0 0.9412001793949905 5 P0DP25 1 +Protein localization to early endosome 0.4428960441764096 0.4057188652286116 0.684949179200053 1.0 0.9415342358411278 5 O14786,P15311,P35241 3 +Er associated misfolded protein catabolic process 0.41530833038102 0.4054430311075778 0.6851518859526662 1.0 0.9415342358411278 6 Q9BUN8,P46379 2 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.2835768958884143 0.401833313067171 0.6878067036012028 1.0 0.942273856049786 39 Q9Y2U8,P53999,Q15942,O00400,Q13526,P49354,P40763,Q9UIQ6 8 +Mrna modification 0.3670562965826078 0.4011188734353101 0.6883326059814037 1.0 0.942273856049786 9 Q69YN4,Q08J23 2 +Lymphocyte apoptotic process 0.3487563384995435 0.3995138996660341 0.6895145840518291 1.0 0.942731300520004 11 P17931,O00273,P14174 3 +Regulation of alternative mrna splicing via spliceosome 0.3001294455165731 0.398887511063647 0.6899760918637867 1.0 0.942739610665372 27 P51116,Q96T37,P38159,Q13247,Q9Y2W1,P98175,Q8WXF0,Q07666 8 +Regulation of dna methylation 0.3576282797356754 0.398498825695871 0.6902625237358269 1.0 0.9429235091067938 10 Q8NB78,O14744 2 +Positive regulation of mrna processing 0.3102766660580164 0.3972215584805599 0.691204085841435 1.0 0.943805021682002 20 Q96EP5,Q15427,P38159,Q9Y2W1,P98179,Q14011 6 +Negative regulation of developmental growth 0.3830533349265848 0.3972111051924811 0.6912117936569637 1.0 0.943805021682002 8 Q8N0X7,P11413,Q00535,O60271 4 +Receptor catabolic process 0.3992464492879051 0.3939523766119241 0.693616199760339 1.0 0.9466717803322428 7 Q96J02,Q00535,P07384 3 +Establishment of protein localization to endoplasmic reticulum 0.321055646971033 0.3917952256067082 0.6952095230330322 1.0 0.9480231181581398 18 Q15042,P61009,O76094 3 +Regulation of cardiac muscle contraction by calcium ion signaling 0.4112833095276782 0.391330952752855 0.6955526224463229 1.0 0.9482726202835708 6 P28161 1 +Regulation of exosomal secretion 0.397678999723787 0.3883017549452777 0.6977927386983551 1.0 0.94996394043729 7 Q99816,O43633,Q9UN37 3 +Muscle contraction 0.2927866802459228 0.387986541007398 0.6980259936993995 1.0 0.94996394043729 33 P28161,Q9NYL9,P30626,P0DP25,P61586,Q14353,P35609 7 +Response to organic cyclic compound 0.2516554752924784 0.3877828464963621 0.698176740672221 1.0 0.94996394043729 141 O75874,P48506,O60828,P04179,P04083,P00374,O15143,Q9H7B4,P61586,Q92600,P49721,Q86X55,Q14258,Q02790,P49321,P15311,P41440,P35613,O95831,O14745,P50570,O75592,Q13126,Q99829,P11413,P27695,P40763,P0DP25,Q00535,O14744,P11802,P28161 32 +3 utr mediated mrna stabilization 0.3805331197459571 0.3877337637632775 0.6982130668161433 1.0 0.94996394043729 8 Q13148,P16989 2 +Negative regulation of response to dna damage stimulus 0.3040013894258343 0.3875722731488931 0.6983325909419726 1.0 0.94996394043729 24 P14174 1 +Imp catabolic process 0.5973017170891329 0.386948200721842 0.6987945562598026 1.0 0.94996394043729 2 P00491 1 +Allantoin metabolic process 0.5973017170891329 0.386948200721842 0.6987945562598026 1.0 0.94996394043729 2 P00491 1 +Regulation of dna metabolic process 0.2401215222780327 0.3819783842518359 0.702477398016145 1.0 0.95201068630528 118 Q9H1E3,Q9H4L7,P49750,P53999,P35637,O00273,Q8NB78,Q9NW82,O95831,Q9NXR7,Q9BRT9,Q9NRR5,O14744,Q9NQ88,P43246,P15927,Q15014 17 +Positive regulation of double strand break repair via homologous recombination 0.3445990383714191 0.3819602807390003 0.7024908263153442 1.0 0.95201068630528 11 Q15014 1 +Cellular macromolecule localization 0.2267793244328786 0.3812187394433352 0.7030409450866626 1.0 0.95201068630528 410 Q9NT62,Q8TEX9,P61009,Q9NPA0,Q9H7B2,P04792,Q7Z4Q2,Q92973,O76094,P20645,O60749,Q15904,O43660,Q7L2J0,Q9BUN8,O60830,Q5JRA6,P43246,Q8NFQ8,O75340,Q06124,Q8TAG9,Q15555,P40616,Q9BW83,Q9Y5X3,Q13526,P35606,P41440,Q9UNZ2,Q9H4M9,P51858,P20290,Q99816,Q92688,P35613,O95831,Q9H223,O14737,Q9H6Z4,Q15042,O14745,Q9BXS5,P83436,Q9P258,Q9Y5K6,Q96AX1,P27695,P20339,Q13148,Q9BVK6,O00471,Q15691,P49354,P40763,P0DP25,P17931,O43592,Q00535,P55786,Q9UHB9,Q15436,P15927,O60684 64 +Trna methylation 0.3619769348388287 0.3812107660071206 0.7030468610943661 1.0 0.95201068630528 9 O75648,Q9BV44,P57081 3 +Endomembrane system organization 0.2457573055154957 0.3801558117835111 0.7038297582803097 1.0 0.952389403661124 106 O43633,Q9NPA0,Q9UQB8,P41440,Q9UNZ2,P40616,Q9BVK6,Q9ULX6,Q15075,Q15042,O14745,P83436,O14744,Q5JRA6,Q8NFQ8 15 +Regulation of dna demethylation 0.5846358466300654 0.3800073031013583 0.7039399940103959 1.0 0.952389403661124 3 Q13263 1 +Nucleotide excision repair dna gap filling 0.5948487326247014 0.3797412844268036 0.70413747116736 1.0 0.9524061075938792 2 Q07864 1 +Nuclear membrane organization 0.3286816762541623 0.3795774890987219 0.7042590734413998 1.0 0.9524061075938792 16 O43633,Q14203,Q9ULX6,Q9UNZ2 4 +Insulin secretion 0.3062259057471501 0.3793112114646024 0.7044567751038517 1.0 0.9524660512507988 21 O43768,P30626,P04083,O95563,Q06124 5 +Developmental growth 0.2570361625319614 0.3785990658191709 0.7049856159768342 1.0 0.9527661970002482 80 Q16555,Q7Z6E9,P80723,P78344,P04083,O14786,Q9Y3A5,Q15149,O95470,Q06124,P31150,O60271,Q14247,P10644,Q96HC4,Q9BRT9,P61201,Q6PD62,Q14353,Q9Y696,P15311,P16989,Q9C0B1,P50570,Q6Y7W6,Q7Z4V5,Q99829,P11413,P11047,Q8N0X7,P18206,P40763,O00763,Q00535,Q13263,P11802,O75312 37 +Regulation of translation in response to endoplasmic reticulum stress 0.5838256425222501 0.3777710517693094 0.7056006802528545 1.0 0.9527728715544416 3 Q04637 1 +Positive regulation of translation in response to stress 0.5838256425222501 0.3777710517693094 0.7056006802528545 1.0 0.9527728715544416 3 Q04637 1 +Positive regulation of translation in response to endoplasmic reticulum stress 0.5838256425222501 0.3777710517693094 0.7056006802528545 1.0 0.9527728715544416 3 Q04637 1 +Regulation of atp dependent activity 0.3003155121758444 0.3755285551761879 0.7072674137579797 1.0 0.9543960537672868 25 P52701,Q96T88,P25685,P50570,P54652,P43246,Q8WXX5,Q8NFQ8 8 +Regulation of rna splicing 0.2566899194487853 0.3751008149757082 0.7075854909474288 1.0 0.9546178359295096 79 Q15427,Q96T37,Q96PU8,Q5BKZ1,Q9Y2W1,O60828,Q15637,P98175,Q8WXF0,P98179,Q14011,Q96EP5,Q12872,P51116,P38159,P61978,Q13247,P78362,Q9NYV4,P35637,Q9NTZ6,O00422,O75312,P22626,Q07666 25 +Neural crest cell migration 0.4797453135145666 0.3740200131929934 0.7083894266464965 1.0 0.955064922192362 4 O14786 1 +Positive regulation of nitric oxide metabolic process 0.4332595224536247 0.37382830338411 0.7085320606344947 1.0 0.955064922192362 5 P04179 1 +Oocyte maturation 0.4793374821261708 0.3727823920066447 0.7093104089129381 1.0 0.955164474185091 4 Q9Y5A9 1 +Negative regulation of neuron apoptotic process 0.3026749190974056 0.371603204358306 0.7101883029544507 1.0 0.9560523219915756 23 P51858,P48506,P04179,O75312,Q07812,P61586,P43246,Q01105 8 +Positive regulation of protein metabolic process 0.2654010902953383 0.3708792760852128 0.7107274513861435 1.0 0.9561180547578076 257 Q9UBT2,Q9C0C2,Q07666,Q16763,P60228,P48506,P67809,P78344,O14786,Q9H3P2,P98179,Q14011,Q99873,Q9H7B4,P61586,P08670,Q9BUN8,Q04637,Q12824,Q9ULT8,Q06124,Q13363,P35579,O75340,P14174,Q92600,Q13155,Q9Y376,Q6PKG0,P35241,Q567V2,Q9Y4X5,P56537,Q13526,Q9UL46,Q15257,Q6PD62,P54619,P54652,Q5VTR2,Q96A26,P14635,P15311,P61964,P16989,P41440,P51116,P63208,P46379,P45974,Q7Z478,Q92688,Q9UBV8,O95831,Q9H223,O14737,Q96A49,Q15042,O75592,O43847,Q99627,Q96S59,Q9Y5A9,Q96T88,Q9ULX6,Q9NR28,P49354,P40763,P0DP25,Q00535,P46777,Q07812,Q9NVI1,Q06323,Q96J02 75 +Sarcoplasmic reticulum calcium ion transport 0.3925685319152718 0.3700916105670245 0.7113142328302757 1.0 0.9561180547578076 7 P28161,P0DP25 2 +Regulation of dna methylation dependent heterochromatin assembly 0.4047522476709939 0.3688353882301627 0.7122504255037656 1.0 0.9563465952013488 6 Q13263 1 +Regulation of peptidyl lysine acetylation 0.3301839614355504 0.3687381890863456 0.7123228807227782 1.0 0.9563465952013488 15 Q13363 1 +Regulation of extracellular matrix disassembly 0.59035159443991 0.3666901186717162 0.7138501780727107 1.0 0.9572570310262984 2 Q7Z460 1 +Positive regulation of extracellular matrix disassembly 0.59035159443991 0.3666901186717162 0.7138501780727107 1.0 0.9572570310262984 2 Q7Z460 1 +Regulation of rrna processing 0.4041184976852575 0.3666798212609009 0.7138578600133314 1.0 0.9572570310262984 6 Q9Y5A9 1 +Regulation of arp2 3 complex mediated actin nucleation 0.5899427636958381 0.3655141428086794 0.714727651625847 1.0 0.957292785093059 2 Q9Y2A7 1 +Positive regulation of arp2 3 complex mediated actin nucleation 0.5899427636958381 0.3655141428086794 0.714727651625847 1.0 0.957292785093059 2 Q9Y2A7 1 +Prostate gland development 0.4760728525887036 0.3629368745184997 0.7166520402750658 1.0 0.9584485967541216 4 P04083 1 +Actin filament bundle organization 0.2874136295475434 0.361164011244721 0.7179768438198215 1.0 0.9584485967541216 34 P15311,Q9UQB8,Q9Y624,Q05682,P35241,Q15942,P16949,Q13177,O14786,P60953,P61586,O00151 12 +Ectodermal placode development 0.4753082572727066 0.360646934182117 0.7183633988266211 1.0 0.9584485967541216 4 O14786 1 +Amyloid precursor protein catabolic process 0.3372690699379611 0.3605704621929082 0.7184205736614016 1.0 0.9584485967541216 12 Q13526,Q15392,P27695 3 +Cellular component disassembly 0.2430576008321137 0.3597577091360463 0.7190283317118424 1.0 0.9588073738309087 127 Q9NT62,O43633,Q9NYL9,Q14203,Q99570,P16949,Q12824,P33176,Q01105,P51452,Q15555,Q9Y3C8,P35241,Q9NRR5,P54652,Q9UPY3,P35609,Q8N543,Q9Y281,P41440,Q99816,Q92900,O95831,Q08945,Q9NQ88,P17096,O00273,Q9UN37,P11047,Q9ULX6,Q07812,Q00535,Q96AX1,O95104 34 +Positive regulation of protein containing complex assembly 0.2729791464279956 0.3592140465408644 0.7194349693290607 1.0 0.9589377891250196 45 Q9UQB8,Q14203,Q15691,Q04637,P23381,P61586 6 +Tetrahydrofolate metabolic process 0.3474980693144285 0.3578328523912837 0.7204684035972548 1.0 0.9594511371185932 10 P34896,Q9NRN7 2 +Neutrophil migration 0.3382087359656445 0.3555477182667818 0.7221793029988235 1.0 0.959894812289034 11 P35613 1 +Synaptic vesicle exocytosis 0.3333893483255971 0.3549380212439755 0.7226360236947575 1.0 0.959894812289034 13 P20339,P0DP25,Q15042 3 +Neuron projection guidance 0.3082679179755478 0.3548103390684428 0.722731682234915 1.0 0.959894812289034 19 Q8TEY7,Q8WX93,P11047,P35613,O75592,O95372 6 +Telomerase holoenzyme complex assembly 0.5750319891868405 0.3538752739315153 0.7234323581031441 1.0 0.959894812289034 3 Q15185 1 +Regulation of tau protein kinase activity 0.5750319891868405 0.3538752739315153 0.7234323581031441 1.0 0.959894812289034 3 P06400 1 +Positive regulation of microtubule polymerization or depolymerization 0.3354807616829128 0.3531006960774699 0.7240129510620235 1.0 0.959894812289034 12 Q15691 1 +Vitamin biosynthetic process 0.5854456255110467 0.3526956340589757 0.724316632809999 1.0 0.959894812289034 2 P14550 1 +L serine biosynthetic process 0.5854456255110467 0.3526956340589757 0.724316632809999 1.0 0.959894812289034 2 O43175 1 +Water soluble vitamin biosynthetic process 0.5854456255110467 0.3526956340589757 0.724316632809999 1.0 0.959894812289034 2 P14550 1 +Membrane biogenesis 0.307596136470746 0.3513743119038651 0.7253075514375085 1.0 0.9604107880152956 19 O43633,P41440 2 +Regulation of muscle system process 0.2989270642614057 0.3504085276036839 0.7260321274957637 1.0 0.960486513903902 23 P61586,P11413,P0DP25,P28161 4 +Ribonucleoside diphosphate biosynthetic process 0.3992522028674136 0.3502941277456111 0.7261179718188158 1.0 0.960486513903902 6 Q05682,P30085,P11172 3 +Imp metabolic process 0.3365752837972334 0.3489113079838406 0.7271558955105555 1.0 0.9609785297128216 11 P30520,P07741,O15067,P00491,P30566 5 +Regulation of megakaryocyte differentiation 0.3982733042490494 0.3470340520559035 0.7285657367797982 1.0 0.9620227993626508 6 Q99873,Q96T37 2 +Regulation of cellular response to insulin stimulus 0.3359056855986509 0.3462047459446929 0.7291888482694067 1.0 0.962159100895806 11 Q9H1E3,Q06124 2 +Regulation of protein acetylation 0.3116936281991412 0.3449643744928562 0.7301211536461325 1.0 0.962930428809516 18 Q13363 1 +Regulation of organ growth 0.3524390681911751 0.3448814769042514 0.7301834765320467 1.0 0.962930428809516 9 P80723,P16989 2 +Regulation of signal transduction by p53 class mediator 0.2893174167062748 0.3434102848691985 0.7312898232637097 1.0 0.9637754249719096 30 P14174,Q9UNS2,Q9H7B2,P46777,O14744,O43324,P61927 7 +Histone ubiquitination 0.3112930871555296 0.3430062516653647 0.7315937570124689 1.0 0.9639191025216284 18 Q7Z6Z7,P63208,Q96T88,Q9NW82,Q5VTR2,Q6PD62 6 +Organelle assembly 0.2584407869345852 0.3419513045197229 0.732387538878386 1.0 0.9646079780349474 170 Q9NT62,Q7Z2Z2,O43633,Q9NYL9,Q8WWM7,Q9H7B2,Q14203,Q14011,P61586,A6NIH7,Q15555,P26196,P35241,Q567V2,P56537,Q9NQW6,Q8TC07,P35609,P52732,Q8N543,P15311,P18085,Q9Y281,Q9UNZ2,Q9H4M9,Q99816,Q7Z478,Q7L2E3,Q9H223,Q9UBB4,Q15042,P05198,P50570,Q9Y5A9,P27695,Q9Y520,P20339,Q9NVX2,Q9UN37,O00471,Q15691,P46777,Q14157 43 +Regulation of synaptic transmission glutamatergic 0.4685015394858695 0.3405335489310591 0.7334547623891758 1.0 0.964751000296972 4 Q15042 1 +Regulation of neurogenesis 0.2773461399794215 0.3398345290746419 0.7339811433379815 1.0 0.964751000296972 38 Q9Y5A9,P27695,Q9UQB8,Q8N0X7,O14744,Q9UPY3,Q96G23 7 +Protein localization to microtubule 0.3960120696555255 0.3395504210323021 0.7341951201709844 1.0 0.964751000296972 6 Q15691 1 +Amp metabolic process 0.3290613598361358 0.3366437674786619 0.736385458348529 1.0 0.966219066815812 13 P22102,P30520,P07741,P00568,O15067,P55263,P30566 7 +Regulation of cellular response to stress 0.2416776297293077 0.3358958932282274 0.7369493740510613 1.0 0.966219066815812 128 P04792,P04179,Q9NXR7,Q99873,Q04637,P14174,Q9NRR5,O43324,Q15014,P55145,P16989,P25685,Q9NQ88,Q96G23,Q5TBB1,P35637,Q04323,Q96J02,P15927 19 +Regulation of integrin mediated signaling pathway 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 0.966219066815812 2 P35221 1 +Cell migration 0.2524088911133441 0.3353254368788198 0.7373796075274068 1.0 0.966219066815812 153 P04792,Q9Y624,P04179,P04083,P61586,Q5JRA6,Q06124,O75340,Q13630,Q8WX93,P14174,Q8TEY7,Q15555,Q99439,Q01518,O60271,P31949,P35241,Q9NQW6,Q5VTR2,O00151,P18085,P35613,Q02952,O14745,Q9P258,Q92766,Q9Y5K6,Q96G23,Q9NUQ9,O43776,P27695,O95684,P11047,Q15691,P40763,P17931,Q00535 38 +Regulation of lipid storage 0.3822078027487365 0.3342198260851064 0.7382136843074036 1.0 0.9667454617353388 7 O60664,Q9C0B1 2 +Response to purine containing compound 0.3308127274434164 0.3338837634121246 0.7384672723350083 1.0 0.9668736582754378 12 P28161,Q86X55,P27695,P35613 4 +Spindle localization 0.3280275487199913 0.3323284483638288 0.7396412607429508 1.0 0.9674614925324156 13 P35579,Q9UNZ2,Q14203,O43264,Q14974 5 +Regulation of long chain fatty acid import into cell 0.5780866721177519 0.332192542688167 0.7397438744183173 1.0 0.9674614925324156 2 P07814 1 +Vascular endothelial growth factor production 0.5772690106296081 0.3299513459989638 0.7414367254428251 1.0 0.967779263970969 2 P49591 1 +Negative regulation of centriole replication 0.5772690106296079 0.3299513459989632 0.7414367254428256 1.0 0.967779263970969 2 Q96PK6 1 +Positive regulation of binding 0.2685117167211297 0.327926571249915 0.7429671826746669 1.0 0.968477372881965 47 Q8TEY7,Q04637,P41440,P60228,Q13526,Q15691,P19474,P0DP25,O60869,Q00535,Q9BUN8 11 +Pentose phosphate shunt 0.363704212821623 0.326729941645733 0.7438721518848723 1.0 0.9690467932043332 8 Q9NQ88,P11413 2 +Recombinational repair 0.2684747259177585 0.3257037679984026 0.7446484931112793 1.0 0.9694302817054046 46 Q9H1E3,P46063,Q9NRR5,Q15014 4 +Ncrna export from nucleus 0.3916061854607341 0.325161145243158 0.7450591137759246 1.0 0.969576088966574 6 Q9H814 1 +Response to ethanol 0.3282300077487786 0.3234310771118203 0.7463687970623627 1.0 0.971076938981201 12 P61586 1 +Dicarboxylic acid transport 0.3277480557375355 0.3214950236985213 0.7478352827882984 1.0 0.9717173852417712 12 Q15042,P41440 2 +Negative regulation of reactive oxygen species metabolic process 0.337781834603909 0.3204332171864647 0.7486399482496469 1.0 0.9717173852417712 10 Q9NQ88,P61586 2 +Regulation of nervous system development 0.267972849965923 0.3202428186009142 0.7487842663822057 1.0 0.9717173852417712 41 Q9Y5A9,P27695,Q9UQB8,Q8N0X7,Q00535,O14744,Q9UPY3,Q96G23 8 +Polyketide metabolic process 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.9717173852417712 3 P14550,P15121 2 +Aminoglycoside antibiotic metabolic process 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.9717173852417712 3 P14550,P15121 2 +Tertiary alcohol metabolic process 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.9717173852417712 3 P14550,P15121 2 +Amine transport 0.4160729564437685 0.319590455011183 0.7492788109943389 1.0 0.9717173852417712 5 Q15042 1 +Centrosome duplication 0.3271918304101149 0.3192663271885311 0.7495245645794217 1.0 0.9717173852417712 12 O43633 1 +Regulation of actin filament bundle assembly 0.3063679739623349 0.3192501405768926 0.7495368379288176 1.0 0.9717173852417712 18 Q9Y624,P35241,P16949,O14786,P60953,P61586 6 +Regulation of gastrulation 0.5731807031888886 0.3188581351479827 0.7498340918000914 1.0 0.9717173852417712 2 Q7Z460 1 +Regulation of endothelial cell differentiation 0.4156576265782227 0.3183242031831459 0.750239026935307 1.0 0.9719823420083542 5 Q9Y624 1 +Positive regulation of ruffle assembly 0.5611451942740328 0.3175956777299368 0.7507916531940169 1.0 0.9723117088321812 3 Q7L576,Q8NCA5 2 +Regulation of smad protein signal transduction 0.5607361963190245 0.3165551792842538 0.7515811496502898 1.0 0.9725607291786412 3 Q8N1F7,Q01082 2 +Detection of stimulus 0.3260993946697266 0.3149070791775108 0.7528322064657684 1.0 0.9729631638194428 12 P0DP25,P04179 2 +Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.559918200409003 0.3144790997251945 0.7531571878677523 1.0 0.9731806360088936 3 A5YKK6,Q9H2U1 2 +Regulation of double strand break repair 0.2862309320996229 0.313998631813831 0.7535220779087757 1.0 0.9731907360071346 27 Q9NRR5,Q15014 2 +Clathrin dependent endocytosis 0.3232521216736781 0.3126762979308817 0.7545266047909991 1.0 0.973574785007233 13 P09497,Q9H3U1,P50570 3 +Multi organism reproductive process 0.2377620100835113 0.3121584809825591 0.7549200839576882 1.0 0.973574785007233 124 Q9BQE5,P43246,Q15645,Q9BW83,P54727,P54652,Q14353,Q02790,P16989,P41440,Q8NB78,P35613,Q9UIQ6,O75592,Q9Y5A9,Q6P6C2,Q9BXW9,P40763,Q14157,O60684 20 +Positive regulation of protein phosphorylation 0.2502467921561696 0.3120446432603326 0.7550065955914593 1.0 0.973574785007233 78 Q99627,P54652,P14174,Q04637,P41440,Q9Y376,Q13526,Q9H223,Q96A49,P0DP25,Q9H7B4,P61586,Q06124 13 +Regulation of cytoplasmic translation 0.3172968289337127 0.3118075925296555 0.7551867535233239 1.0 0.973574785007233 15 P16989 1 +Autophagosome organization 0.3156254328760925 0.3046901387223347 0.7606021608834315 1.0 0.9774880133607644 15 Q9NT62,Q15042,Q9UNZ2 3 +Excretion 0.5559063440381691 0.3043926131643916 0.760828794808202 1.0 0.9774880133607644 3 O14745 1 +Negative regulation of transmembrane transport 0.3120760331201427 0.3041209732802971 0.7610357287829905 1.0 0.9774880133607644 16 Q9Y376,P30626,P0DP25,O14745,P28161 5 +Meiotic cell cycle 0.2657693085080147 0.3030887061916899 0.7618222607584375 1.0 0.9774880133607644 44 P35579,Q15645,P27694,Q9Y5A9,P52701,Q9UQ84,P46379,Q15021,Q9NTJ3,Q9BXW9,Q08J23,P54652,O43264,O43683,P30153 15 +Protein localization to cytoskeleton 0.3205323031226939 0.3016953644027743 0.7628843023960097 1.0 0.9774880133607644 13 Q15691,Q9UNZ2 2 +Endoderm development 0.3563020278139018 0.3012459129758328 0.7632269813979513 1.0 0.9774880133607644 8 Q6PD62 1 +Antigen processing and presentation of exogenous peptide antigen 0.4546732984030681 0.3012447160414679 0.7632278940485839 1.0 0.9774880133607644 4 Q9UIQ6 1 +Multicellular organism growth 0.2908605698851043 0.3011418646110044 0.7633063184775 1.0 0.9774880133607644 22 Q7Z6E9,P40763,Q9C0B1,P11802,Q6Y7W6,Q14353,Q06124 7 +Organelle inheritance 0.3561475409836135 0.3007233631636543 0.7636254517411742 1.0 0.9774880133607644 8 P27361,P06493,Q92538,Q02750,P28482,P63104,Q08379 7 +Microvillus organization 0.3832369699537927 0.2985515108511908 0.7652822675540651 1.0 0.9781869100809109 6 Q06124,O14745 2 +Mechanoreceptor differentiation 0.3712750519853399 0.2979909374478502 0.7657100804616717 1.0 0.9781869100809109 7 Q9BW83 1 +Mrna methylation 0.3825002546726859 0.2962558975870454 0.7670346635479248 1.0 0.9784672547931405 6 Q69YN4 1 +Positive regulation of amyloid precursor protein catabolic process 0.5525562372188175 0.2960929786808392 0.7671590759121838 1.0 0.9784672547931405 3 Q96S59,Q13492 2 +Muscle tissue development 0.2667773398200271 0.2945991752994129 0.7683000922418257 1.0 0.9784672547931405 40 Q9Y5Q8,P11413,P16989,Q9Y281,P41440,Q99873,P61586 7 +Erbb signaling pathway 0.3010337934081739 0.2942156547930459 0.7685931189824378 1.0 0.9784672547931405 18 P27695,Q99816,P62993,Q9Y5X3,Q93034,Q06124 6 +Dna integrity checkpoint signaling 0.2742335774479461 0.2933628513782318 0.7692448172107003 1.0 0.9786670873965309 36 Q6Y7W6,P51530,Q9BXW9,Q9NXR7,Q92547,P43246,P15927,Q06124 8 +Activation of gtpase activity 0.3204440916917756 0.2927281280029489 0.7697299681594256 1.0 0.9786670873965309 12 Q8TC07,O60343 2 +Transcription initiation from rna polymerase ii promoter 0.3179278844817528 0.2913284931229018 0.7708000977012246 1.0 0.9786670873965309 13 P53999 1 +Positive regulation of type i interferon production 0.3002835863562658 0.2907548079107675 0.7712388508048773 1.0 0.9786670873965309 18 O60828,P41440 2 +Release of cytochrome c from mitochondria 0.3173600444104538 0.2890877583722533 0.7725142212563421 1.0 0.9786670873965309 13 Q96A26,Q9H3K2,P04179 3 +Regulation of striated muscle cell differentiation 0.3521527023306803 0.2873466265554214 0.7738469244123407 1.0 0.9786670873965309 8 P11413,Q15014 2 +Epithelial cell proliferation 0.2747747169199456 0.2869163587938168 0.7741763643682784 1.0 0.9786670873965309 35 Q15648,O14786,P22392,O75340,P58107,P09429,P52758,Q02750,Q9UII2,Q13247,Q6ZWJ1,P60953,Q6P1J9,Q92766,Q9H2J4,P11047,Q96T88,P40763,P06400,Q07812,Q15418 21 +Synapse maturation 0.5609157808667303 0.2867329878197363 0.7743167770384787 1.0 0.9786670873965309 2 P63104 1 +Regulation of histone methylation 0.2832186870011455 0.2863833391832429 0.7745845339725776 1.0 0.9786670873965309 26 Q6PD62,Q9H3P2,P61964,Q12824 4 +Muscle cell development 0.2870410923165618 0.2858606611726861 0.774984844815767 1.0 0.9786670873965309 23 Q9NYL9,P06493,P11413,Q9Y281,P10644,Q96HC4,Q15149,Q9H7B4,P35609 9 +Positive regulation of intracellular steroid hormone receptor signaling pathway 0.5605069501226583 0.2856926237013732 0.7751135547756087 1.0 0.9786670873965309 2 Q15648 1 +Myofibroblast differentiation 0.5605069501226584 0.2856926237013729 0.775113554775609 1.0 0.9786670873965309 2 P06400 1 +Positive regulation of smad protein signal transduction 0.5605069501226584 0.2856926237013729 0.775113554775609 1.0 0.9786670873965309 2 Q8N1F7 1 +Positive regulation of mitochondrial depolarization 0.5605069501226579 0.2856926237013721 0.7751135547756096 1.0 0.9786670873965309 2 P63244 1 +Positive regulation of supramolecular fiber organization 0.2745027367314443 0.2851555715959875 0.7755249565535409 1.0 0.9786670873965309 35 Q9Y281,Q9UQB8,Q14203,Q15691,P61586 5 +Positive regulation of translational initiation 0.3201082478461549 0.2848175694899455 0.775783910982601 1.0 0.9786670873965309 11 Q7Z478,Q6PKG0,Q9Y5A9,Q07666 4 +Relaxation of muscle 0.4485815690743723 0.2846386447592937 0.7759210011433313 1.0 0.9786670873965309 4 P28161 1 +Regulation of protein targeting to membrane 0.3780366343073645 0.2825135563954251 0.7775497532720481 1.0 0.9786670873965309 6 Q00535,P31150 2 +Late endosome to vacuole transport 0.4476220387390536 0.2820634783043832 0.7778948367453726 1.0 0.9786723938794092 4 O43633 1 +Cellular response to endogenous stimulus 0.2559801046174854 0.2814827178364066 0.7783401816245705 1.0 0.9790082007228522 178 Q9UQB8,P48506,P04083,P43490,Q9H7B4,P61586,Q9UQ13,Q92600,Q06124,O60343,P07741,P62993,P34896,P35241,Q86X55,Q9Y5X3,O00400,Q13526,P35609,Q02790,Q9H1E3,Q9Y2U8,Q9H4M9,O95831,O14737,Q96A49,O14745,Q9NQ88,P17655,P27695,Q15942,P49354,P40763,Q8N0X7,Q00535,O14744,P11802,P28161,O75312 39 +Transcytosis 0.377416857663261 0.2806282646741556 0.7789955347497428 1.0 0.9790654261882014 6 P20339,O60763 2 +Cell morphogenesis involved in neuron differentiation 0.2450882346430522 0.2802436910548767 0.7792905484246906 1.0 0.9791932059736256 70 Q9UQB8,O60828,P78344,P16949,O14786,P33176,Q06124,Q8TEY7,Q8WX93,Q04917,Q14247,Q96HC4,O95372,P41440,Q9BTW9,P35613,P60953,P50570,O14745,O60678,O75592,P11047,Q13177,Q8N0X7,P18206,Q00535 26 +Protein localization to nuclear body 0.318834632745171 0.2800846473518148 0.7794125631445461 1.0 0.9791932059736256 11 P17987,P78371,O60832,Q4G0J3,Q7L2J0,P50991,P49368,P40227,P50990,Q99832 10 +Regulation of protein containing complex assembly 0.2461025939459685 0.2747746319929645 0.7834893889148322 1.0 0.980171981963062 86 Q9NYL9,Q9UQB8,Q14203,Q14019,P16949,O15143,O15144,Q04637,P61586,P23381,Q06124,Q14247,P62993,P35241,Q02790,Q9BTW9,Q9NUQ9,Q15691,P17931,Q07812,Q92747 21 +Lipid droplet organization 0.348259629153672 0.2745666078773844 0.783649223699231 1.0 0.980171981963062 8 Q15042 1 +Oocyte differentiation 0.3638225050376407 0.2743150783785977 0.783842497923346 1.0 0.980171981963062 7 Q9Y5A9 1 +Regulation of dna recombination 0.2618038911559473 0.2738391144375368 0.7842082631273868 1.0 0.980171981963062 43 Q9NRR5,Q9H4L7,Q15014 3 +Regulation of keratinocyte migration 0.5429593227772207 0.2729514370739026 0.7848905460922635 1.0 0.980171981963062 3 Q15555 1 +Keratinocyte migration 0.5429593227772207 0.2729514370739026 0.7848905460922635 1.0 0.980171981963062 3 Q15555 1 +Chromatin organization 0.2399433542363133 0.2729043091890025 0.7849267739617243 1.0 0.980171981963062 135 Q8TEX9,Q96T37,Q9NXR7,Q99733,Q12824,Q9H7B4,Q8WXX5,Q01105,Q13363,Q9H4L7,Q9Y2K7,Q86X55,Q6PD62,Q5VTR2,O14646,O15047,P49321,Q9H1E3,P61964,Q9H9B1,Q8NB78,Q92688,P05204,Q92900,Q08945,O95983,P17096,Q96T88,Q8WXI9,O14744 30 +Facultative heterochromatin assembly 0.3150797910584818 0.272310685615616 0.7853831406437317 1.0 0.980354369182541 12 O43159,Q13547,Q99549,Q13263,O95983 5 +Negative regulation of cilium assembly 0.542331288343564 0.2714703511660514 0.7860293001325005 1.0 0.9807459240901012 3 P27816,P50570 2 +Actin filament organization 0.2456330483149005 0.2669982992552788 0.7894704705709858 1.0 0.9832396737011532 82 Q9NYL9,P29966,Q9UQB8,Q9Y624,Q14019,P16949,O15143,O14786,O15144,P61586,Q14247,P62993,P35241,P59998,O00151,P35609,P15311,Q9Y281,Q05682,P60953,Q9Y5K6,Q9NUQ9,Q15942,Q13177,Q92747 25 +Regulation of dna helicase activity 0.5402862985685151 0.2666764578490142 0.7897182815928645 1.0 0.9832396737011532 3 P49736,P33993 2 +Positive regulation of mrna metabolic process 0.2555636477973704 0.2662362562581011 0.790057261870595 1.0 0.9832396737011532 56 Q96EP5,Q9Y5A9,Q92945,Q13148,Q9Y2W1,P67809,Q92900,Q9C0B1,P98179,Q14011,Q9Y2L1,Q6Y7W6,O00178,Q969T7 14 +Regulation of erythrocyte differentiation 0.322818477507468 0.2662142430224558 0.7900742143584347 1.0 0.9832396737011532 10 P40763,Q99873 2 +Positive regulation of nf kappab transcription factor activity 0.284007845647222 0.2660056035283377 0.7902348934657983 1.0 0.9832396737011532 22 P19474 1 +Replication fork processing 0.3450381472944352 0.2641868126473723 0.7916359721779742 1.0 0.9843931492241128 8 Q9H1E3 1 +Microvillus assembly 0.440570542782489 0.2634845864362259 0.7921771021966715 1.0 0.984868829758024 4 O14745 1 +Regulation of mrna processing 0.2444255988576782 0.2600759767425467 0.7948051682432897 1.0 0.9859080770560664 76 Q96T37,Q96PU8,Q9Y2W1,Q15637,P98175,Q8WXF0,P98179,Q14011,O00267,Q96EP5,Q12872,Q5VTR2,Q6PD62,P51116,P61978,P38159,Q13247,P78362,Q69YN4,Q16630,Q8N684,O00422,P22626,Q07666 24 +Regulation of amino acid transport 0.4389496401238599 0.2593011943857251 0.7954028579315411 1.0 0.9859382672485568 4 Q15042 1 +Regulation of protein binding 0.2637732696131237 0.2591782490973169 0.7954977125584795 1.0 0.9859382672485568 39 Q15691,Q9BUN8,P19474,P41440 4 +Regulation of dna repair 0.2616692127388867 0.2587250994318218 0.795847352229532 1.0 0.9859382672485568 40 P35637,Q9NXR7,Q9NRR5,Q9NQ88,P15927,Q15014 6 +Connective tissue development 0.2830755447907593 0.2586067477562712 0.7959386763653791 1.0 0.9859382672485568 21 P43490 1 +Alternative mrna splicing via spliceosome 0.2672357293101023 0.2580990284332261 0.7963304813826544 1.0 0.9859382672485568 37 P51116,Q96T37,Q13247,O60828,Q12872,P98175,Q8WXF0,Q07666 8 +Regulation of cell substrate adhesion 0.2744824178068506 0.2577819991576288 0.7965751576822395 1.0 0.9859382672485568 31 Q13630,P51452,P50570,Q9BTW9,O14786,O15144,P60953,P61586,Q9P258,Q92766 10 +Negative regulation of smoothened signaling pathway 0.4379833863027379 0.2568231217751973 0.7973153200030996 1.0 0.9859382672485568 4 P17612 1 +Regulation of cell cycle 0.2603254046926431 0.2567609553058138 0.7973633129158335 1.0 0.9859382672485568 224 Q06323,O43633,Q9NYL9,Q14203,P41227,P51530,P78344,P04083,Q99570,O43660,Q9NXR7,P19474,Q9Y6G9,Q9UJX4,O95373,Q7L2J0,Q08J23,P61586,Q92547,Q04637,P43246,Q06124,Q13363,P51452,P31350,P30260,Q15645,Q15392,P35241,Q9NUQ3,Q13526,Q9NQW6,Q9UL46,P54652,Q8TBC4,Q5VTR2,Q15014,P06730,P14635,P52732,P43487,P61964,Q9UNZ2,Q99816,P39748,Q6ZWJ1,P78362,O14745,Q9NYV4,Q6Y7W6,Q9P258,Q5TBB1,Q92733,Q9Y5A9,P27695,Q13148,Q9NVX2,O15355,Q9UN37,Q7Z7L1,Q9BXW9,Q9UJX2,P40763,P0DP25,Q00535,O14744,P11802,Q07812,Q8N6R0,P15927 70 +Receptor clustering 0.3426665295880126 0.2566606835429694 0.7974407249735502 1.0 0.9859382672485568 8 P49354 1 +Vesicle mediated transport between endosomal compartments 0.3007774143710328 0.256495767129636 0.7975680484889942 1.0 0.9859382672485568 16 P20339,P15311,P35241,Q15075 4 +Blastocyst development 0.2791327023111065 0.2561798435101634 0.7978119719720533 1.0 0.9859382672485568 25 P49321,P31350,Q9NVX2,Q9BRT9,Q12824,P17655,Q6PD62,O75312 8 +Purine deoxyribonucleotide catabolic process 0.5482420278005001 0.2554228504148894 0.7983965238848558 1.0 0.9859382672485568 2 P00491 1 +Response to cocaine 0.3689170878704857 0.255349647321977 0.7984530574905322 1.0 0.9859382672485568 6 Q00535 1 +Positive regulation of rig i signaling pathway 0.4373977086742999 0.2553268279867265 0.7984706807229165 1.0 0.9859382672485568 4 Q9Y4E8,Q14671,Q9NUD5 3 +Regulation of cation transmembrane transport 0.270689680107003 0.2527847251000777 0.8004345720447936 1.0 0.9862599883797256 34 P11413,P27695,Q9Y376,P30626,P07384,P0DP25,Q07812,Q00535,P50570,P54652,P28161,O14745,P35609 13 +Amyloid precursor protein metabolic process 0.3078701708026766 0.2527097222213251 0.8004925344470719 1.0 0.9862599883797256 13 Q13526,Q15392,P27695 3 +Positive regulation of intracellular transport 0.2574524054148664 0.2520187706757316 0.8010265550772173 1.0 0.9862599883797256 50 P68036,P35241,P35609,P15311,P06493,P17612,Q9H4M9,P26038,Q92688,O14737,P60953,Q16630,Q7Z6Z7,Q13148,Q00535,Q13263,P55786,O75312,O00410,Q07666 20 +Mitotic cytokinesis 0.2767962234026451 0.2511302184796566 0.8017134333882214 1.0 0.9862599883797256 26 Q9NQW6,P61586,O43633,Q6DKK2 4 +Dna replication independent chromatin organization 0.3919679612036346 0.2498702193307487 0.8026877143560069 1.0 0.986804881193577 5 Q8TEX9 1 +Regulation of system process 0.2582191596817129 0.2485027727967183 0.8037454249721598 1.0 0.986804881193577 45 P28161,Q06124,Q9UQB8,Q9C0B1,P0DP25,O14745,P61586,Q9UPY3 8 +Positive regulation of cell population proliferation 0.2408054724080409 0.2480766479422267 0.8040751032090612 1.0 0.9868155707039468 95 O75340,P14174,Q9H2J4,Q13247,O95684,P11047,P07384,P04083,P43490,P40763,Q99873,Q92766,Q5TBB1,Q99584 14 +Receptor metabolic process 0.2744044007952552 0.2480562801514065 0.8040908619459377 1.0 0.9868155707039468 28 P15311,P41440,P62993,P20339,P07384,P49354,Q00535,P50570,Q96J02 9 +Spliceosomal snrnp assembly 0.2785528453135271 0.2471142339124611 0.804819818214676 1.0 0.9870643063790712 24 Q8WXF0,Q16637,O14744 3 +Regulation of golgi organization 0.4339379140987996 0.2465767980790289 0.805235762638552 1.0 0.9871762852124624 4 P50570 1 +Positive regulation of stem cell differentiation 0.3905034793286954 0.2458929362997779 0.8057651120062095 1.0 0.9871762852124624 5 Q13610,Q12948,O43809,Q9H2U1 4 +Positive regulation of double strand break repair 0.3010234529590102 0.2453342740493496 0.8061976156282484 1.0 0.9871762852124624 15 Q15014 1 +Fibroblast migration 0.3090460848747921 0.2448588731133309 0.8065657069252747 1.0 0.9871762852124624 11 Q9P258,O00151,Q02952,O95470 4 +Calcium ion transport 0.2574454654581888 0.2444964139266489 0.8068463789868299 1.0 0.9871762852124624 41 P28161,P11413,P27695,P17931,P0DP25,Q00535,P54652,P61586,Q93034 9 +Regulation of transcription involved in g1 s transition of mitotic cell cycle 0.4327541896951076 0.2436183117633506 0.8075264447914154 1.0 0.9871762852124624 4 Q00535 1 +Regulation of protein glycosylation 0.5429272281275644 0.2428822547540332 0.8080966126749647 1.0 0.9871762852124624 2 Q9UHD1 1 +Positive regulation of protein glycosylation 0.5429272281275644 0.2428822547540332 0.8080966126749647 1.0 0.9871762852124624 2 Q9UHD1 1 +Response to inorganic substance 0.2430296579841124 0.242788158797349 0.8081695090750001 1.0 0.9871762852124624 82 O75340,Q99720,Q99829,P11413,P27695,Q99707,P48506,P09960,O60888,P04179,P35613,P04083,O95831,P0DP25,P17655,Q9NQ88,O75592 17 +Mapk cascade 0.2399772965464703 0.2421959094450899 0.8086283645033983 1.0 0.9871762852124624 68 Q92905,Q96KB5,O14786,Q99873,Q06124,P51452,P09429,P14174,O60271,P62993,P56537,Q13526,P15311,P06493,P31689,Q13098,Q02952,P60953,O14745,Q6IAA8,Q96S59,Q9UMX5,Q13177,P30046,O14744,Q96J02,P30153 27 +Ear development 0.2931238410166353 0.2406463991364584 0.809829185416759 1.0 0.9871762852124624 17 Q9BW83,Q92688,O14745 3 +Ovarian follicle development 0.3636976074081468 0.2403734301311069 0.8100407741366966 1.0 0.9871762852124624 6 Q9UI10 1 +Response to carbohydrate 0.2726368066179611 0.2402755475087272 0.8101166500849606 1.0 0.9871762852124624 29 P48506,Q9UI10,P04179,Q9NR50,O95563,Q12824,P61586 7 +Synapse organization 0.256710908778325 0.2398097833239618 0.810477722257757 1.0 0.9871762852124624 47 Q9UQB8,Q04637,Q14203,P11047,Q13526,P49354,P61586,O60678 8 +Positive regulation of neurogenesis 0.2729034358028939 0.2397550146442093 0.8105201829746889 1.0 0.9871762852124624 28 O94874,P31150,Q9UQB8,P27695,Q13547,P78344,O14786,Q14444,P55209,O14744,Q9UPY3 11 +Positive regulation of nervous system development 0.2729034358028939 0.2397550146442093 0.8105201829746889 1.0 0.9871762852124624 28 O94874,P31150,Q9UQB8,P27695,Q13547,P78344,O14786,Q14444,P55209,O14744,Q9UPY3 11 +Antimicrobial humoral immune response mediated by antimicrobial peptide 0.388187200552068 0.2396655457267565 0.8105895470725493 1.0 0.9871762852124624 5 P04406,P05204 2 +Negative regulation of calcium ion transport 0.337070206194272 0.2392973875893082 0.81087499097551 1.0 0.9871762852124624 8 P28161,P0DP25 2 +Negative regulation of cell cycle 0.2410932403607494 0.2390406176545747 0.8110740871958646 1.0 0.9871762852124624 72 O43633,P51530,P41227,Q9Y6G9,Q9NXR7,Q08J23,Q92547,P43246,Q06124,Q15645,O14745,Q6Y7W6,Q5TBB1,Q9NVX2,Q9UN37,Q9BXW9,Q00535,Q8N6R0,P15927 19 +Positive regulation of dna repair 0.274518753250009 0.238986602868104 0.8111159711470481 1.0 0.9871762852124624 26 Q9NQ88,Q9NXR7,P35637,Q15014 4 +Kidney epithelium development 0.3145135404681433 0.2380342349715075 0.8118545415338243 1.0 0.9873320553501128 10 P80723 1 +Negative regulation of reproductive process 0.3872204266836532 0.2370894183615869 0.8125874212911626 1.0 0.9873320553501128 5 Q15645 1 +Negative regulation of striated muscle cell differentiation 0.4298894714322211 0.236533546990307 0.8130186789452971 1.0 0.9873320553501128 4 P11413,P67809 2 +Regulation of mrna splicing via spliceosome 0.2499470456832364 0.2361856042770233 0.8132886496811296 1.0 0.9873320553501128 58 Q96EP5,Q96T37,P51116,Q96PU8,P61978,P38159,Q13247,Q9Y2W1,Q15637,P98175,Q8WXF0,P98179,Q14011,Q12872,P78362,O00422,P22626,Q07666 18 +Response to interleukin 4 0.351167592174807 0.2361308874354596 0.8133311068102558 1.0 0.9873320553501128 7 P11802 1 +Ires dependent viral translational initiation 0.3129801474740924 0.232988510661126 0.8157703274551058 1.0 0.987572940029946 10 P56537 1 +Response to bmp 0.302043793649269 0.2314135382400573 0.8169935485894362 1.0 0.987572940029946 13 O00400,Q8N0X7,Q9Y2U8 3 +Protein heterooligomerization 0.3342519744663468 0.2307683079839091 0.8174948032933433 1.0 0.987572940029946 8 Q8N684,P31350,Q16630 3 +Regulation of receptor localization to synapse 0.5372035977105576 0.2297751618769354 0.8182664863077753 1.0 0.987977819056823 2 O15400 1 +Ovulation cycle process 0.5236256734405782 0.229295516503675 0.8186392379753895 1.0 0.987977819056823 3 O75592 1 +Nucleosome assembly 0.2706538166871532 0.2292727861076245 0.8186569036964426 1.0 0.987977819056823 29 Q9H7B4,Q01105,Q92688,Q99733 4 +Positive regulation of release of cytochrome c from mitochondria 0.3595985113701935 0.2289124086019199 0.8189369959545472 1.0 0.9880704769531256 6 Q96A26,O14737 2 +Regulation of peptidase activity 0.2394236054800425 0.2286219414888835 0.8191627693442003 1.0 0.988150893090032 66 O75340,Q96A26,O43847,Q9NVX2,P20810,Q15392,Q92688,Q9NR28,P04406,O95831,O14737,P40763,Q04323,Q07812,Q15418,P61586,P35237,Q92530 18 +Cytokinesis 0.2550122682216056 0.226603367124905 0.820732173812764 1.0 0.9895680478456238 46 P35579,O43633,Q6DKK2,Q9NVA2,Q8WUM4,Q9UN37,P16949,Q99570,Q9NQW6,Q13526,O75935,P35580,P0DP25,Q15149,P60953,P61586,P50995 17 +Metal ion transport 0.2375865198849063 0.2257411585874764 0.8214027443082643 1.0 0.9897954989258791 67 P61586,P33176,Q04917,Q9Y376,P30626,P54652,P35609,Q02790,P55011,P50570,O14745,Q93034,P11413,P27695,P17931,Q07812,Q00535,P0DP25,P28161 19 +Protein localization to condensed chromosome 0.3468282580879412 0.223649323392724 0.8230301811100444 1.0 0.9905072528475536 7 O43264,P06493,Q9P258 3 +Negative regulation of fibroblast proliferation 0.3813620760366211 0.2217733244780453 0.8244903463584254 1.0 0.9914959432389276 5 Q07812,P04179 2 +Regulation of lamellipodium organization 0.2989382681703677 0.2203983994312133 0.8255608918368542 1.0 0.9920055313736692 13 Q92766,O15144,P50570 3 +Positive regulation of lamellipodium assembly 0.3306961153869691 0.2202164451917356 0.8257025895757943 1.0 0.9920055313736692 8 P50570,Q16658,Q9Y2A7,O15144,P60953 5 +Peptide metabolic process 0.2277846186296527 0.2198038282447059 0.8260239380372394 1.0 0.9921657998624872 337 Q7Z2Z2,P61009,P04792,O75874,Q9UJ14,P60228,Q92945,Q7L2H7,P48506,Q96PU8,P04179,P00374,P67809,P78344,O75822,P84098,P98179,Q14011,Q9Y2L1,P61586,Q04637,Q92600,P23381,P26196,P29692,P34896,Q567V2,O95182,P56537,Q13526,P23588,Q9Y262,O00178,P61927,P55010,O43324,P05387,Q8N543,P51116,P16989,Q7Z478,P09960,P55884,Q92900,Q9C0B1,P05198,Q9UIQ6,P24534,Q6Y7W6,O75592,P43897,P26639,O43776,Q99829,P11413,Q9Y5A9,P27695,Q13148,Q15418,Q9UI10,Q9NR50,P04406,P40763,Q13310,P46777,P55786,P28161,P83881,Q969T7,Q07666 70 +Maintenance of dna repeat elements 0.5190777619062346 0.2196217421401682 0.8261657570191501 1.0 0.9921657998624872 3 P43246 1 +Regulation of type i interferon mediated signaling pathway 0.3013945826148686 0.2187992356328414 0.8268064423260875 1.0 0.99274323411543 11 Q9Y5A9 1 +Establishment of protein localization to mitochondrial membrane 0.2998255315826708 0.2177640425219194 0.8276129621171819 1.0 0.9929312109144078 12 O14737,Q07812,P0DP25 3 +Stress granule disassembly 0.517401999268551 0.2161157318416437 0.8288975372342269 1.0 0.9929312109144078 3 P33176 1 +Endothelial cell proliferation 0.2989238193018753 0.214710041514091 0.8299933931667154 1.0 0.9929312109144078 12 O75340,Q9H2J4 2 +Chromosome organization involved in meiotic cell cycle 0.2927930272136351 0.2142543044339359 0.8303487503388831 1.0 0.9929312109144078 15 Q15645,P46379,Q9NTJ3,Q9BXW9,O43683,P30153 6 +Locomotion 0.2498668476570709 0.2141818973475174 0.8304052123545556 1.0 0.9929312109144078 175 P04792,Q9Y624,Q9Y2I1,P04179,P04083,O14786,O15144,O95470,P61586,P11233,Q5JRA6,P33176,Q06124,P35579,P51452,O75340,P14174,Q13630,Q8WX93,Q8TEY7,Q99439,Q15555,Q01518,O60271,P31949,P35241,Q13526,Q9NQW6,Q5VTR2,O00151,O95372,P18085,Q9Y281,P55011,P35613,Q02952,O14745,Q9P258,Q92766,O75592,Q96G23,Q9Y5K6,Q9NUQ9,O43776,P27695,O95684,P11047,Q15691,P40763,P17931,Q00535,Q07812 52 +Regulation of defense response 0.2377260951893595 0.2130786480706891 0.8312656185903355 1.0 0.9929312109144078 71 Q9Y5A9,Q15942,O60828,P04083,Q9BXW9,P19474,P28070,Q96J02 8 +Negative regulation of cell cycle process 0.241498646989387 0.212613290628599 0.8316286040358167 1.0 0.9929312109144078 63 O43633,Q15645,Q6Y7W6,P51530,P41227,Q9BXW9,Q9Y6G9,Q9NXR7,P15927,Q92547,P43246,Q8N6R0,Q5TBB1,Q06124 14 +Striated muscle cell apoptotic process 0.4197288346021561 0.2122759731783131 0.8318917389172715 1.0 0.9929312109144078 4 Q9NQ88 1 +Positive regulation of b cell activation 0.3063956645864835 0.2118966722040954 0.8321876468460898 1.0 0.9929312109144078 10 P14174 1 +Nephron development 0.296423033294027 0.2116521606381172 0.8323784127525364 1.0 0.9929312109144078 13 P80723 1 +Membrane to membrane docking 0.5143247254089134 0.2097600735762481 0.8338549364270371 1.0 0.9929312109144078 3 P15311 1 +Fructose 1 6 bisphosphate metabolic process 0.3520769974497811 0.2085878049374971 0.8347700314242641 1.0 0.9929312109144078 6 Q9NQ88 1 +Cellular response to dsrna 0.3117313017897091 0.2076917658438894 0.8354696473965642 1.0 0.9929312109144078 9 P41440 1 +Striated muscle cell differentiation 0.259105654350651 0.2066811272051928 0.8362588974699041 1.0 0.9929312109144078 37 P35579,Q9NYL9,P11413,Q9Y281,O60271,P41440,Q9H4M9,P67809,P17655,Q9H7B4,P35609,Q15014 12 +Negative regulation of retinoic acid receptor signaling pathway 0.5265739983646873 0.2065471964735601 0.8363635019811124 1.0 0.9929312109144078 2 A5YKK6 1 +Trophoblast cell migration 0.5265739983646869 0.2065471964735592 0.8363635019811131 1.0 0.9929312109144078 2 Q07021 1 +Regulation of dendritic cell chemotaxis 0.5265739983646869 0.2065471964735592 0.8363635019811131 1.0 0.9929312109144078 2 Q07021 1 +Import across plasma membrane 0.2975805479310398 0.2063134256452513 0.8365460919766623 1.0 0.9929312109144078 11 P41440 1 +Protein heterotetramerization 0.3403605101046121 0.2056477761741084 0.837066055071755 1.0 0.9929312109144078 7 Q8N684,P31350,Q16630 3 +Microtubule cytoskeleton organization 0.2254959945406485 0.2054292831193924 0.83723674349867 1.0 0.9929312109144078 118 O43633,Q15018,Q96PK6,Q86Y56,Q14203,Q9P287,Q9HC35,Q9NVM9,P16949,Q9Y6G9,Q9Y3A5,P61586,O43264,P35579,Q8TEY7,Q15555,Q8WUM4,Q8IWJ2,Q13526,Q15257,Q14974,O43237,Q02790,P14635,P52732,P15311,P06493,P43487,Q9UNZ2,Q9BTW9,Q9Y266,Q9BUF5,P68371,Q7Z460,Q8NI77,Q96S59,Q8N3U4,O95684,Q15813,Q15691,O14530,P04406,Q00535,O75312,P30153 45 +Sensory organ development 0.2519417216336539 0.2047879261561211 0.8377378206320043 1.0 0.9929312109144078 44 P11047,Q9BW83,Q92688,P40763,Q15042,Q99471,O14745,Q06124 8 +Regulation of response to stress 0.2537297732595007 0.2022060262488418 0.8397556621759894 1.0 0.9929312109144078 197 P04792,Q9UJ14,O60828,P04179,P04083,Q9NXR7,P19474,Q99873,Q04637,Q06124,P14174,Q9NRR5,P28070,O43324,Q15014,P55145,P16989,Q13247,P25685,Q9NQ88,Q92766,Q96G23,Q5TBB1,Q9Y5A9,P35637,Q15942,Q04323,Q9BXW9,P15927,Q96J02 30 +Cellular response to ionizing radiation 0.270378446786521 0.1992133882850487 0.8420958269812939 1.0 0.9929312109144078 20 P62993,Q9NXR7,Q9H1E3 3 +Positive regulation of rna splicing 0.2701491971927919 0.1984674703892634 0.842679333370695 1.0 0.9929312109144078 21 Q96EP5,P38159,Q9Y2W1,P98179,Q14011,O75312 6 +Regulation of actomyosin structure organization 0.2857314255765933 0.1983196903539989 0.8427949469665013 1.0 0.9929312109144078 16 Q9Y624,P16949,O14786,P60953,P61586 5 +Regulation of brown fat cell differentiation 0.4135010557615911 0.1980933440637032 0.8429720323162073 1.0 0.9929312109144078 4 Q9C0B1 1 +Regulation of autophagy 0.2356789753078382 0.1980440223267754 0.8430106209565229 1.0 0.9929312109144078 66 P21281,Q8TEY7,P04792,P07384,Q9Y5X3,P19474,P40763,Q9NRR5,Q15042,Q9NQ88,Q04637 11 +Regulation of gtpase activity 0.2525218134676804 0.1977515123834682 0.8432394844073423 1.0 0.9929312109144078 40 Q15555,O60343,Q9Y624,P35241,Q9P258,P16949,Q13526,Q15042,Q8TC07 9 +Microtubule based movement 0.2464933199646976 0.197556656713907 0.8433919492768587 1.0 0.9929312109144078 56 P52732,Q13409,P04792,Q14203,Q9BW83,Q9Y6G9,O14745 7 +Regulation of cytokinesis 0.2785151941221918 0.1973255369486889 0.8435727966064062 1.0 0.9929312109144078 18 Q13526,P61586 2 +Regulation of cardiac muscle contraction 0.3015404764443478 0.1969547410934171 0.8438629553545127 1.0 0.9929312109144078 10 P28161,P0DP25 2 +Negative regulation of cysteine type endopeptidase activity 0.2850219666323323 0.195733688837797 0.8448186145246026 1.0 0.9929312109144078 16 Q9NVX2,P61201,Q15392,P20810,Q15418 5 +Regulation of cytosolic calcium ion concentration 0.2817396479811649 0.1956132005616419 0.8449129273374041 1.0 0.9929312109144078 17 P27695,P30626,P0DP25,Q00535,P28161 5 +Response to thyroid hormone 0.346284528366558 0.1935729796477723 0.8465102571024385 1.0 0.9929312109144078 6 Q9Y376,P48506 2 +Limbic system development 0.2842232327634327 0.1928397684490856 0.8470844572725054 1.0 0.9929312109144078 16 P27695,Q07812,Q00535,Q15042,A0AVT1 5 +Focal adhesion assembly 0.2806421525794683 0.1914755270272902 0.8481530524109715 1.0 0.9929312109144078 17 P51452,Q14247,P12814,P18206,O14786,P61586,Q9P258,P35609 8 +Response to heat 0.2619894886593769 0.1910142463523269 0.8485144316868811 1.0 0.9929312109144078 32 O75340,P48506,Q9UI10,Q9NR50,P25685,P54652 6 +Presynaptic endocytosis 0.2992905590154562 0.1902100649164689 0.8491445244393314 1.0 0.9929312109144078 10 P0DP25,Q00535 2 +Acidic amino acid transport 0.3200032194257679 0.1899320074601265 0.8493624106407556 1.0 0.9929312109144078 8 Q15042,O14745 2 +Signal transduction in absence of ligand 0.299042535950598 0.1894735846668184 0.8497216564829364 1.0 0.9929312109144078 10 Q86WB0,Q07812 2 +Imp biosynthetic process 0.3196721311475475 0.1890296603786185 0.8500695702234438 1.0 0.9929312109144078 8 P22102,P07741,P00492,P22234,Q06203,O15067,P30566 7 +Cell cycle checkpoint signaling 0.2489384861278347 0.1890197879861506 0.8500773077780568 1.0 0.9929312109144078 49 Q15645,Q6Y7W6,P51530,Q9BXW9,Q9Y6G9,Q9NXR7,P15927,Q92547,P43246,Q5TBB1,Q06124 11 +Regulation of developmental growth 0.2523925670379959 0.1853730228756613 0.8529364663303975 1.0 0.9940539022219136 39 P15311,P50570,P11413,P16989,O60271,P80723,P78344,Q8N0X7,O14786,Q9C0B1,P40763,Q00535,O95470,P11802,Q14353 15 +Pyrimidine nucleoside diphosphate biosynthetic process 0.3654355796299262 0.1827640440227996 0.8549831620763506 1.0 0.9940539022219136 5 Q05682,P11172 2 +Pyrimidine nucleoside diphosphate metabolic process 0.3654355796299262 0.1827640440227996 0.8549831620763506 1.0 0.9940539022219136 5 Q05682,P11172 2 +Intra golgi vesicle mediated transport 0.2888456187139706 0.1819341884618375 0.8556343737117962 1.0 0.9940539022219136 12 P35606,Q9UBF2,Q9Y678,P53618,P83436,P61923,P53621 7 +Negative regulation of nucleobase containing compound metabolic process 0.2547778421800121 0.1801867128266479 0.8570059893366744 1.0 0.9949536724211532 234 Q96T37,P80723,P48506,Q15637,P98175,Q8WXF0,Q9H3P2,Q14011,Q7L2J0,Q99471,P43246,Q01105,Q13363,Q9Y2K7,Q9H814,Q8WX92,Q12872,Q9NRR5,Q6PD62,Q9UPY3,Q9H9B1,P16989,P41440,P53999,Q13247,P51858,Q99816,Q8NB78,P25685,Q9NQ88,Q92766,P17096,P27695,P35637,Q13148,O00273,Q8WXI9,P40763,Q00535,O14744,O95104,Q92804,Q8N6R0 43 +Positive regulation of nucleocytoplasmic transport 0.2656150545395278 0.1794912591478034 0.8575519800709064 1.0 0.995029483602453 22 Q16630,P06493,Q13148,Q92688,Q13263,O75312,O00410,Q07666 8 +Membrane organization 0.2434582832371679 0.177641628786623 0.8590044294180499 1.0 0.9958334866516888 164 O43633,Q9NPA0,Q92734,Q9H3K2,Q9UQB8,Q14203,P04083,P61586,Q15075,Q5JRA6,Q8NFQ8,O75340,O60343,Q15392,Q00169,Q8IWA4,Q9Y2U8,P41440,Q9UNZ2,O14745,Q9BVK6,Q9ULX6,P49354,P0DP25,Q15436 25 +Nucleotide excision repair 0.2844732936315178 0.1776367920052571 0.8590082281993139 1.0 0.9958334866516888 14 P09884,Q07864,P15927,P54727 4 +Mitotic g2 dna damage checkpoint signaling 0.2873103082344294 0.1771642676540497 0.8593793619259835 1.0 0.9958334866516888 12 Q9NXR7 1 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.4970974516602529 0.1761822145092882 0.8601507929919558 1.0 0.9958334866516888 3 O95373 1 +Negative regulation of transcription by rna polymerase ii 0.223300959492819 0.1757505325757534 0.8604899338764835 1.0 0.9958334866516888 111 Q9UPN9,P67809,Q9UHI6,P98175,Q7L2J0,O00267,Q13363,P09429,Q92785,Q4G0J3,Q96MG7,P61201,Q9UPY3,Q6PD62,Q9Y3F4,P15311,Q9H9B1,P16989,P41440,Q99816,P51858,Q8NB78,P49591,P63104,P25685,Q6P1J9,Q92766,O14776,O95983,Q9UNF1,Q13547,Q96T88,Q8WXI9,P40763,Q13263,O95104,P22626,Q8N6R0,Q07666 39 +Negative regulation of carbohydrate metabolic process 0.3132121830951216 0.1718580336093256 0.8635491399521307 1.0 0.997886147953616 8 P40763 1 +Synaptic vesicle priming 0.4944785276073717 0.1713787682353107 0.8639259482864095 1.0 0.9980807925701224 3 O95721,P54920 2 +Response to vitamin 0.2988519444683539 0.1711533542673985 0.8641031841100157 1.0 0.9980807925701224 9 P50747,Q96C86,Q14258,P04179 4 +Negative regulation of biosynthetic process 0.2523316610891246 0.170228657099336 0.8648303155079118 1.0 0.9984376760186154 257 P02656,Q8WXF1,Q92945,Q96T37,P60228,Q9UPN9,P80723,P48506,P00374,Q15637,P98175,Q9H3P2,Q14011,Q7L2J0,Q99471,P61586,Q04637,Q9Y2L1,Q92600,Q01105,Q13363,Q9Y2K7,P26196,P34896,P31949,P56537,Q8WX92,Q6PD62,Q9UPY3,P15311,Q9H9B1,P16989,P41440,Q99816,P51116,P51858,P61978,Q8NB78,Q92900,Q9C0B1,P25685,P05198,Q6Y7W6,O60678,Q92766,O95983,P17096,Q9Y5A9,P27695,Q13148,Q96T88,Q7Z7L1,Q8WXI9,P04406,Q8N6R0,P40763,Q00535,Q13263,O14744,O95104,Q969T7,Q07666 62 +Response to dopamine 0.2848383011295894 0.1696106745718379 0.8653163270971982 1.0 0.9986025358686406 12 O14744,O14745 2 +Midbody abscission 0.3261099079500882 0.168615925321698 0.8660987533314812 1.0 0.9986025358686406 7 O43633,Q9UN37 2 +Mitochondrial fusion 0.2850622729020063 0.1677852140524284 0.8667522550667055 1.0 0.9987186751312874 11 Q9NWX6 1 +Dna damage response signal transduction by p53 class mediator 0.2827565560607838 0.1669635124600961 0.8673987587102909 1.0 0.9987186751312874 13 P14174,O43324 2 +Response to type i interferon 0.2827206422010342 0.1668525411031822 0.8674860762734564 1.0 0.9987186751312874 13 Q9Y5A9 1 +Tail anchored membrane protein insertion into er membrane 0.3108337385437126 0.1657458977250946 0.8683569244146261 1.0 0.9991543133342422 8 P46379,Q9NPA0 2 +Negative regulation of organelle assembly 0.3106557377049224 0.1652930609383023 0.8687133202664872 1.0 0.9991543133342422 8 P50395,Q96PK6,P27816,P38398,Q8WVM8,P50570,O75396 7 +Hormone transport 0.2597207692009733 0.1650028497926396 0.8689417389935707 1.0 0.9991543133342422 26 O43768,P30626,P04083,O95563,Q06124 5 +Muscle system process 0.245768273252615 0.1649406047611646 0.8689907320963353 1.0 0.9991543133342422 43 P28161,Q9NYL9,P11413,P30626,P0DP25,P61586,Q14353,P35609 8 +Tor signaling 0.2825318925915157 0.1627049071615513 0.8707507831237273 1.0 0.999697238528073 12 O75340,Q96B36 2 +Hematopoietic stem cell homeostasis 0.3957180329906909 0.1605510501726626 0.8724470109173388 1.0 1.0 4 Q14157 1 +Regulation of protein containing complex disassembly 0.2562841393220116 0.1605368461043196 0.8724581990081741 1.0 1.0 32 Q8N543,Q9NYL9,Q9Y281,P35241,Q9NRR5,O95104,P35609 7 +Positive regulation of transcription elongation from rna polymerase ii promoter 0.3222185826084386 0.1591510160955912 0.8735498953600898 1.0 1.0 7 Q9NYV4,Q6P1J9,O14776 3 +Protein insertion into er membrane 0.288351107465144 0.1590756885851499 0.8736092420015216 1.0 1.0 10 Q9NPA0,O43765,Q96A33,Q15006,P61619,P46379,Q8N766,O43681,O43402 9 +Mitotic g2 m transition checkpoint 0.279867768603238 0.1581480378737944 0.8743401481211137 1.0 1.0 13 Q9NXR7 1 +Regulation of protein dephosphorylation 0.2602673497131846 0.1566548049650288 0.875516907604136 1.0 1.0 22 Q13526,P17931,P0DP25,Q15257 4 +Chromosome organization 0.2465183524348742 0.1565092541271008 0.8756316253935954 1.0 1.0 282 O43633,Q8TEX9,Q96T37,Q9UQ84,P41227,P51530,P04083,Q9NXR7,Q9Y6G9,Q9UJX4,Q99733,Q9H7B4,P43246,Q01105,Q13363,Q15645,Q9H4L7,Q9Y2K7,Q9BRT9,Q6PD62,P54652,O14646,O15047,P49321,Q9H1E3,Q9H9B1,P61964,P41440,Q8NB78,Q92688,O95831,P46063,P17096,P49750,Q9ULX6,Q9BXW9,Q9UJX2,O14744,O15347,P15927 40 +Actin nucleation 0.2872644255569049 0.1561356866998729 0.8759260693842994 1.0 1.0 10 Q9Y2A7,O15143,O15144,P59998,Q92747 5 +Arp2 3 complex mediated actin nucleation 0.2872644255569049 0.1561356866998729 0.8759260693842994 1.0 1.0 10 Q9Y2A7,O15143,O15144,P59998,Q92747 5 +Positive regulation of peptidase activity 0.2547326961542064 0.15604199769503 0.8759999172879338 1.0 1.0 33 O75340,Q96A26,Q92688,O95831,O14737,P40763,P61586 7 +Process utilizing autophagic mechanism 0.2230419940489166 0.1560171228412993 0.8760195244211249 1.0 1.0 109 Q9NT62,O43633,P04792,P19474,Q04637,Q8TEY7,Q9Y3C8,Q9Y5X3,Q9NRR5,Q9UNZ2,Q99816,P07384,Q15042,Q9NQ88,P21281,P27695,P20339,P40763,Q96AX1 19 +Mitotic cell cycle process 0.250778012832625 0.1557914104958739 0.8761974413866809 1.0 1.0 202 O43633,Q9NYL9,Q15018,Q07666,Q16763,Q14203,P41227,Q9P287,P51530,P04083,O43660,P16949,Q9NXR7,Q9Y3A5,Q9Y6G9,Q9UJX4,Q7L2J0,P61586,Q92547,O43683,O43264,Q04637,P43246,P31350,P30260,Q15645,P33991,O43768,Q8WUM4,P35241,Q15021,Q13526,Q9BY42,Q9NQW6,Q9UL46,Q15257,Q9GZZ1,P54652,Q14974,P06730,P49321,P14635,P52732,P06493,P43487,Q9UNZ2,Q07864,Q9NTJ3,Q86XL3,P15927,P33993,Q9Y266,P60953,P50570,P35580,Q6Y7W6,Q9P258,P09884,Q93034,Q5TBB1,Q6DKK2,P27695,Q8N3U4,Q9UN37,Q15813,Q9ULX6,Q7Z7L1,Q9BXW9,Q9UJX2,P0DP25,Q00535,O14744,P11802,O75312,Q06323,P30153 76 +Virion assembly 0.2871250892105478 0.1557607356035926 0.8762216212461627 1.0 1.0 10 P26196,O43633,Q99816 3 +Nucleoside diphosphate metabolic process 0.2486217044788858 0.1532087367770193 0.8782336680640348 1.0 1.0 38 P30085,P31350,Q05682,P00338,P56537,Q9UDY2,P04406,P11172,P17858,P40763,P18669,Q9NQ88,P54619,P36871 14 +Positive regulation of mrna 3 end processing 0.3520261972984048 0.1530103183309059 0.8783901382594059 1.0 1.0 5 Q9H2U1,Q8N7H5,O43809,Q6P1J9 4 +Xmp metabolic process 0.3195411716509584 0.1528031072545906 0.8785535472789836 1.0 1.0 7 P22102,P12268,P22234,Q06203,O15067,P30566 6 +De novo amp biosynthetic process 0.3195411716509561 0.1528031072545853 0.8785535472789878 1.0 1.0 7 P22102,P30520,P22234,Q06203,O15067,P30566 6 +Negative regulation of cell death 0.2438153332894203 0.1527285541887413 0.878612341943585 1.0 1.0 172 O43633,Q9H3K2,Q9BZZ5,P04792,P04179,P04083,Q9NXR7,P61586,Q04637,P43246,Q01105,Q5VZE5,P14174,Q86WB0,Q15392,P16989,Q13247,P51858,O00273,Q9UMX5,Q9BXJ9,Q96J02 22 +Positive regulation of cell cycle process 0.2323063722401122 0.1519446221099571 0.8792306135087009 1.0 1.0 64 Q9NYL9,O43660,P04083,Q9Y6G9,Q9UJX4,Q7L2J0,Q04637,P61586,P31350,P30260,P35241,P54652,P14635,P43487,Q9UNZ2,P39748,Q6ZWJ1,Q9P258,P27695,Q9UJX2,P11802 21 +Epidermis development 0.2466320830420388 0.1506650003602319 0.8802399836703176 1.0 1.0 39 Q13247,Q8WX93,O60568,P04083 4 +Regulation of protein export from nucleus 0.2781564745657535 0.1499843041306624 0.8807769986661607 1.0 1.0 12 Q92688,Q06124 2 +Regulation of attachment of spindle microtubules to kinetochore 0.3501305784036531 0.1490377252393988 0.8815238649439605 1.0 1.0 5 P14635,Q9P258 2 +Regulation of release of cytochrome c from mitochondria 0.284318694351416 0.1483069429434258 0.8821005362781726 1.0 1.0 10 Q96A26,O14737,Q9H3K2 3 +Animal organ morphogenesis 0.2294884015653976 0.1469379353104289 0.8831810088377385 1.0 1.0 71 Q96T37,Q13247,P80723,P11047,P35613,Q9BXW9,O60568,P40763,O14745,P61586,Q14353,O75592 12 +Vesicle fusion to plasma membrane 0.4942763695830038 0.1450698443521729 0.8846557271083939 1.0 1.0 2 O95721 1 +Dna dependent dna replication maintenance of fidelity 0.276780161500019 0.1444301869671491 0.88516078095183 1.0 1.0 11 Q9H1E3,P51530,Q7Z7L1 3 +Positive regulation of cell development 0.242452846518053 0.144304398732482 0.8852601049787647 1.0 1.0 43 O94874,P31150,Q9UQB8,Q9Y624,P60953,P27695,O14744,Q13547,P78344,O14786,O15144,Q14444,P55209,P50570,Q9UPY3,Q92766 16 +Positive regulation of response to dna damage stimulus 0.2516532624902989 0.1441226252736236 0.8854036388519897 1.0 1.0 34 P51116,Q7Z4V5,P35637,Q9NXR7,Q9NQ88,O43324,Q15014 7 +Regulation of transporter activity 0.2530373660012494 0.1438898300221202 0.8855874665815517 1.0 1.0 32 P27695,Q9Y376,P30626,P07384,P0DP25,Q00535,O14745,P54652,P28161,P35609 10 +Telomere maintenance 0.23942371451666 0.1435662663199269 0.8858429802173551 1.0 1.0 55 Q9UQ84,P41440 2 +Ribonucleoprotein complex subunit organization 0.2174476732884522 0.1434555737608703 0.8859303952770055 1.0 1.0 114 Q9Y312,Q9H7B2,Q15428,Q13247,Q7Z478,P56537,Q99590,Q15637,P23588,Q8N684,Q12872,Q8WXF0,O14744,Q9UPY3,Q16637,P55010 16 +Trna modification 0.2603553615033647 0.1425046759916646 0.8866813861593139 1.0 1.0 19 O75648,Q9NWX6,Q9BV44,P57081 4 +Regulation of blood circulation 0.2565155355258048 0.1415224019715661 0.8874572639314442 1.0 1.0 21 P61586,P28161 2 +Regulation of cell substrate junction organization 0.2704224289333199 0.1392641574375222 0.8892414120542151 1.0 1.0 15 P51452,Q15555,O14786,P61586,Q9P258 5 +Antimicrobial humoral response 0.3227184753191652 0.1384428608308576 0.8898904250821527 1.0 1.0 6 P04406,P05204 2 +Regulation of immune system process 0.2359523879544987 0.1383758912630325 0.8899433496882387 1.0 1.0 153 Q96T37,O60828,P04083,P19474,Q99873,P61586,P43246,Q5JRA6,Q06124,P14174,P28070,Q6PD62,P41440,Q9NUQ9,Q9Y5A9,Q9NR50,Q9BXW9,P40763,O15347,Q96J02 20 +Cytosolic transport 0.2415009773115096 0.1380516610917695 0.8901995887356688 1.0 1.0 47 Q14203,O60749,Q99570,Q9P2R3,Q13596,Q15075,P33176,P42566,O60271,P40616,P35241,Q8IWJ2,Q9Y5X3,Q96QK1,P15311,P49257,O43747,P20339,Q9BVK6 19 +Positive regulation of myeloid cell differentiation 0.2729221678376559 0.1378797845574599 0.8903354273838666 1.0 1.0 13 P40763,Q99873 2 +Protein quality control for misfolded or incompletely synthesized proteins 0.2741075092326586 0.1372654383115126 0.8908209880363989 1.0 1.0 11 P36776,Q96TA2,P46379,P55072,Q92890,Q9NYU2,Q13618,Q9BUN8,Q16740,Q9UNE7 10 +Activation of phospholipase d activity 0.4744142842731018 0.1372484748869081 0.8908343959948335 1.0 1.0 3 P40616 1 +Purine nucleoside monophosphate catabolic process 0.474028629856857 0.1366388504360152 0.8913162662810454 1.0 1.0 3 P49902,P00491 2 +Ribonucleoside monophosphate catabolic process 0.474028629856857 0.1366388504360152 0.8913162662810454 1.0 1.0 3 P49902,P00491 2 +Muscle cell differentiation 0.2392396672303469 0.1350662347287941 0.8925595062847573 1.0 1.0 53 P35579,Q9NYL9,P11413,Q9Y281,O60271,Q96PU8,P41440,Q9H4M9,Q7Z4V5,P67809,P04179,P17655,Q9H7B4,P35609,Q15014 15 +Response to calcium ion 0.2580635345592335 0.1342420553553323 0.8932111714909656 1.0 1.0 19 O75340,Q99829,P31150,Q9UBV8,P0DP25,P50995 6 +Regulation of multicellular organism growth 0.2722806065044343 0.133694212019867 0.8936443822134106 1.0 1.0 12 P15311,P40763,Q9C0B1,P11802,Q14353 5 +Negative regulation of protein containing complex disassembly 0.2576678472605345 0.1328347703929283 0.8943240552215932 1.0 1.0 19 Q9NYL9,Q9NRR5,O95104 3 +Regulation of bicellular tight junction assembly 0.3410407184777918 0.1308022202409162 0.89593176659023 1.0 1.0 5 Q9Y624 1 +Intrinsic apoptotic signaling pathway in response to dna damage 0.2535654553468512 0.1301335059053474 0.8964608016282938 1.0 1.0 21 P14174 1 +Reproduction 0.2448290701066565 0.13009012794631 0.8964951205055687 1.0 1.0 183 Q96T37,O75874,Q9UQ84,P80723,P04083,Q15637,Q9BQE5,P43246,Q06124,Q15645,P62993,Q15392,Q9BW83,P54727,P54652,O75718,Q14353,Q02790,P16989,P41440,Q8NB78,P35613,Q9UIQ6,O75592,Q9Y5A9,Q6P6C2,Q9BXW9,P40763,Q14157,O60684 30 +Regulation of response to dna damage stimulus 0.2289542465747175 0.1278965735527403 0.8982308226866911 1.0 1.0 64 Q9H993,P14174,Q9UNS2,P51116,P61978,Q7Z4V5,P35637,Q9NXR7,Q9NRR5,P15927,Q9NQ88,O43324,Q5TBB1,Q15014 14 +Central nervous system neuron differentiation 0.2695458790671436 0.1264256541263871 0.8993949960195369 1.0 1.0 12 Q6Y7W6,O75592 2 +Trachea development 0.3772504091652988 0.1263106770604369 0.8994860048802391 1.0 1.0 4 P27361,Q02750,P35222 3 +Trachea formation 0.3772504091652988 0.1263106770604369 0.8994860048802391 1.0 1.0 4 P27361,Q02750,P35222 3 +Trachea morphogenesis 0.3772504091652988 0.1263106770604369 0.8994860048802391 1.0 1.0 4 P27361,Q02750,P35222 3 +Positive regulation of tyrosine phosphorylation of stat protein 0.4824202780049175 0.1259707813567591 0.8997550533955077 1.0 1.0 2 P22059 1 +Positive regulation of dna demethylation 0.4820114472608455 0.1253452167535248 0.900250256639423 1.0 1.0 2 Q93008 1 +Transforming growth factor beta receptor signaling pathway 0.2517726391726873 0.123379496592744 0.9018065923630658 1.0 1.0 21 Q13526,P49354,P40763,Q15942 4 +Regulation of dephosphorylation 0.2504249887838294 0.123214647850721 0.9019371266465144 1.0 1.0 26 Q13526,P17931,P0DP25,Q15257 4 +Dna replication dependent chromatin organization 0.3146251116365627 0.1217794318960408 0.9030737036641284 1.0 1.0 6 Q8TEX9 1 +Establishment of protein localization to membrane 0.2320671544801363 0.1203727544926147 0.904187873212855 1.0 1.0 60 Q9NT62,O76094,Q15904,P0DP25,Q15042,Q9UHB9 6 +Sodium ion homeostasis 0.3343776166923842 0.1182948991838014 0.9058339988846223 1.0 1.0 5 Q9Y5X3 1 +Positive regulation of protein targeting to membrane 0.3340155546459283 0.1176361566595648 0.9063559549654624 1.0 1.0 5 Q9Y4C2,Q00535,Q9UHD1,Q12955 4 +Response to ischemia 0.2768838977399432 0.1172758173805676 0.9066414877106984 1.0 1.0 9 O95831 1 +Oligodendrocyte differentiation 0.256125939248664 0.1168783256003773 0.9069564740830902 1.0 1.0 18 Q9NR50,Q9UI10,O14744 3 +Regulation of cell cycle process 0.2353926452504861 0.1158832225647992 0.9077450925586787 1.0 1.0 157 O43633,Q9NYL9,Q14203,P41227,P51530,P04083,O43660,Q9NXR7,Q9Y6G9,Q9UJX4,Q08J23,Q7L2J0,P61586,Q92547,Q04637,P43246,Q06124,Q15645,P35241,Q13526,Q9NQW6,P54652,P52732,Q9UNZ2,Q6Y7W6,Q9P258,Q5TBB1,Q9Y5A9,P27695,Q9BXW9,Q9UJX2,P0DP25,O14744,P11802,Q8N6R0,P15927 36 +Protein localization to cell cortex 0.3327875562832594 0.1154179480591838 0.9081138535357648 1.0 1.0 5 P53350,P15311,Q14980,P11171 4 +V d j recombination 0.3707037643207864 0.1153473842641149 0.908169781765817 1.0 1.0 4 P09429,P78527,P49916 3 +Cell division 0.232983750186781 0.1153159373857022 0.9081947064257958 1.0 1.0 151 O43633,Q15018,Q16763,Q14203,P67809,Q9HC35,Q99570,Q9NVM9,P16949,Q9NXR7,Q9Y6G9,Q9UJX4,P23396,Q15149,Q08J23,P61586,O43264,O43683,P11233,O43684,P50995,P35579,Q86WB0,P30260,Q15555,O43768,Q8WUM4,Q15021,Q29RF7,Q13526,Q9NQW6,Q8WWK9,Q92599,Q93008,P14635,P52732,P06493,P61964,P12270,Q99816,O75935,P11171,Q86XL3,O95347,Q9NTJ3,Q9Y266,P60953,P35580,Q9P258,Q7Z460,Q9Y5K6,Q6DKK2,Q9NVA2,Q9Y5A9,Q8N3U4,Q96CT7,Q9UN37,Q9UHD8,Q15691,Q8NFH4,Q9UJX2,P06400,P0DP25,Q8N0X7,Q00535,P11802,P61026 67 +Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.4596132014351995 0.1151033034285664 0.9083632415522138 1.0 1.0 3 Q9UII2 1 +Positive regulation of kinase activity 0.2376652169399006 0.1147548989027674 0.908639398271578 1.0 1.0 47 Q99627,P14174,Q9Y376,Q96A49,P0DP25,Q9NQ88,P61586 7 +Centromere complex assembly 0.3703055919413865 0.1147004190642368 0.9086825817564432 1.0 1.0 4 P49321 1 +Regulation of cell matrix adhesion 0.255404885281952 0.1145721067160698 0.9087842897014264 1.0 1.0 18 P61586 1 +10 formyltetrahydrofolate metabolic process 0.457627295468233 0.1123267069387857 0.9105643667265044 1.0 1.0 3 Q9NRN7 1 +Modulation by host of symbiont process 0.2568828125657262 0.1112496468015062 0.9114183834829684 1.0 1.0 17 Q13148,Q9H1E3,O14646 3 +Viral process 0.2153743292147188 0.1110824482866365 0.9115509668349752 1.0 1.0 116 O43633,P61009,Q9Y624,P19474,Q99873,Q12824,Q15075,Q13363,P42566,O43719,P26196,P56537,Q9Y262,Q13325,O14646,Q9H1E3,Q99816,P55884,P35613,P20339,Q13148,Q96J02,O60684 23 +Positive regulation of posttranscriptional gene silencing 0.2635007707983799 0.1110702454551263 0.911560643406776 1.0 1.0 12 Q04637,P40763 2 +Meiotic sister chromatid cohesion centromeric 0.4566768403094899 0.1110140182148661 0.911605230517111 1.0 1.0 3 P30153 1 +Meiosis ii cell cycle process 0.4566768403094899 0.1110140182148661 0.911605230517111 1.0 1.0 3 P30153 1 +Fear response 0.4565662697827276 0.1108619871388408 0.9117257896031914 1.0 1.0 3 Q04637 1 +Response to transforming growth factor beta 0.2473640091780165 0.1102952432730971 0.9121752295678978 1.0 1.0 26 Q9Y2U8,Q15942,Q13526,P49354,P40763 5 +Physiological cardiac muscle hypertrophy 0.454806913616358 0.1084619581457256 0.9136292554490336 1.0 1.0 3 P11413 1 +Cell communication by electrical coupling 0.2979854782418696 0.1066611985400665 0.9150577660250808 1.0 1.0 7 P0DP25 1 +Negative regulation of canonical wnt signaling pathway 0.2611232924475208 0.1053007533119727 0.916137165243643 1.0 1.0 12 O14745 1 +Golgi vesicle transport 0.2259322254596328 0.1048547190490653 0.9164910897903672 1.0 1.0 92 O75340,P35606,Q92734,Q8TAG9,P40616,Q9BVK6,O00471,Q15436,Q5JRA6 9 +Positive regulation of striated muscle cell apoptotic process 0.4519254030295607 0.104608304814631 0.9166866245768692 1.0 1.0 3 Q9NQ88 1 +Positive regulation of intracellular protein transport 0.2410243886858446 0.1046003637541141 0.9166929260563664 1.0 1.0 37 Q9Y4C2,P06493,P30419,P17612,P12270,P60953,Q7Z6Z7,Q13148,Q9Y282,Q92688,O14737,Q00535,Q13263,P68036,P55786,O75312,O00410,O95071 18 +Positive regulation of multicellular organismal process 0.2360411362791472 0.1033919175372276 0.9176519266401836 1.0 1.0 162 P04792,Q9UQB8,P80723,O60828,P04083,P61586,P43246,Q06124,O75340,P14174,Q9UPY3,P16989,P41440,Q02952,Q9NUQ9,Q9H2J4,P40763,O14744,Q99584,Q96J02,O60684 21 +Regulation of translation in response to stress 0.2655058655521721 0.1032340739114411 0.917777197302069 1.0 1.0 10 Q04637,P05198 2 +Scarna localization to cajal body 0.3629296235679201 0.1031255529114199 0.917863324849979 1.0 1.0 4 P17987,O60832,P78371 3 +Regulation of helicase activity 0.2957683848902863 0.1024207028947645 0.9184227515485645 1.0 1.0 7 P43246,P52701 2 +Viral translation 0.2594589255717717 0.1023918261232348 0.9184456713824548 1.0 1.0 13 P55884,P56537 2 +Mesoderm development 0.2697826978269855 0.1021985909699026 0.9185990461441456 1.0 1.0 9 P06744,P17612,P10644,Q12948,Q16881,P63173,Q8WUM0,Q9Y2G5 8 +Regulation of protein secretion 0.2443505556087335 0.1019480681396116 0.9187978958351466 1.0 1.0 32 P15311,O43768,P55011,P30626,Q96KC8,O95563,P17858,Q6ZWJ1,Q9Y5K6,O75592,Q06124 11 +Vesicle uncoating 0.3619745084443047 0.1016834320762623 0.9190079532625616 1.0 1.0 4 Q9UN37 1 +Protein exit from endoplasmic reticulum 0.2554058951808469 0.1013738770087935 0.9192536727547888 1.0 1.0 16 Q9BUN8,Q9BVK6,Q8IWJ2 3 +Viral release from host cell 0.2590874157106366 0.1004814803551122 0.9199620849558052 1.0 1.0 12 Q99816,O43633,Q14258 3 +Positive regulation of membrane depolarization 0.4486707566462211 0.1003703433752006 0.9200503134045128 1.0 1.0 3 P09874,P63244 2 +Detection of abiotic stimulus 0.3018018018017988 0.0977936928291618 0.922096115771029 1.0 1.0 6 P30419,Q15555,P14923,P19022,P35222 5 +Regulation of response to interferon gamma 0.4466257668711695 0.0977694360071304 0.92211537761088 1.0 1.0 3 P08238,Q15648 2 +Specification of symmetry 0.3592471358428793 0.0976366412774008 0.9222208279639597 1.0 1.0 4 Q9Y673,Q10567,P35222 3 +Nucleotide sugar biosynthetic process 0.2801925154115538 0.0974144918891888 0.9223972366005588 1.0 1.0 8 Q8NBZ7,Q13630 2 +Cell communication by electrical coupling involved in cardiac conduction 0.3221156755151664 0.0971818711087403 0.9225819646523016 1.0 1.0 5 P0DP25 1 +Positive regulation of transcription by rna polymerase i 0.2552404438964269 0.0967746759440036 0.9229053351891054 1.0 1.0 15 Q15061,Q13610,P56192,Q9H6R0,P19338,Q9H8H0,P42345,P17480,Q9UPP1,Q9H583,Q12824,Q8TED0,Q9NX58,Q8IWA0 14 +Steroid hormone biosynthetic process 0.301176698048627 0.0967001800361895 0.922964496853862 1.0 1.0 6 Q9UBM7,Q15648,P56937 3 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.3216837499249905 0.0964830058331008 0.9231369703343224 1.0 1.0 5 Q9NPA0 1 +Exonucleolytic catabolism of deadenylated mrna 0.2665612213325752 0.0957376848916985 0.923728910136749 1.0 1.0 9 Q969T7 1 +Positive regulation of sodium ion transmembrane transport 0.3005733005732967 0.0956512983898245 0.9237975217194472 1.0 1.0 6 O43707,Q12955,P54709,Q9UHD1,P50570 5 +Positive regulation of sodium ion transport 0.3005733005732967 0.0956512983898245 0.9237975217194472 1.0 1.0 6 O43707,Q12955,P54709,Q9UHD1,P50570 5 +Negative regulation of cell cycle phase transition 0.2312773181204482 0.0956137160076255 0.9238273713135284 1.0 1.0 56 Q15645,Q6Y7W6,P51530,Q9BXW9,Q9Y6G9,Q9NXR7,P15927,Q92547,P43246,Q8N6R0,Q5TBB1,Q06124 12 +Negative regulation of proteolysis 0.231274367420033 0.0955956978350058 0.9238416821830644 1.0 1.0 56 Q9H2J4,Q15392,P35237,P19474 4 +Cellular component maintenance 0.300046925205254 0.0947416434240667 0.9245200400554804 1.0 1.0 6 Q14247,Q14203 2 +Spermatid differentiation 0.2553671214818332 0.0942743921776466 0.9248911913827004 1.0 1.0 14 P54652,Q08J23,Q15645,Q07812 4 +Tetrahydrofolate biosynthetic process 0.3192795742939021 0.0926484703831701 0.9261828355197346 1.0 1.0 5 P22102,Q6UB35,P11586,P00374 4 +Folic acid containing compound biosynthetic process 0.3192795742939021 0.0926484703831701 0.9261828355197346 1.0 1.0 5 P22102,Q6UB35,P11586,P00374 4 +Golgi disassembly 0.3555646481178385 0.0923394778711257 0.9264283235328244 1.0 1.0 4 P06493,Q92538,Q08379 3 +Regulation of proteolysis 0.2203613767513023 0.0906207463899562 0.9277939465230672 1.0 1.0 129 Q92530,P48506,P19474,P61586,Q9ULT8,P35579,O75340,Q15392,P20810,Q9Y4X5,Q9UL46,Q9NRR5,P54727,P61201,Q96A26,P46379,P45974,Q92688,O95831,Q96KC8,O14737,P35237,O43847,Q9H2J4,Q9NVX2,Q04323,Q9NR28,P04406,P40763,Q07812,Q00535,P46777,Q15418,Q06323,Q96J02 35 +Nucleotide excision repair dna incision 0.4558462796402376 0.0897913769739254 0.9284530006884792 1.0 1.0 2 Q16658 1 +Negative regulation of mitotic cell cycle phase transition 0.2387335752631801 0.0880001936530645 0.9298765222279316 1.0 1.0 36 Q92547,Q9NXR7,Q9Y6G9,Q6Y7W6,P15927 5 +Positive regulation of phosphorus metabolic process 0.2191257541020551 0.0879333457244912 0.9299296531921066 1.0 1.0 104 Q99627,P54652,P14174,Q9NQ88,Q04637,P41440,Q9Y376,Q13526,Q9H223,Q96A49,P0DP25,Q00535,Q15257,Q9H7B4,P61586,Q06124 16 +Protein targeting to mitochondrion 0.2410314031696594 0.0869534250975029 0.9307085332076696 1.0 1.0 32 O95831,O60830 2 +Cytokine mediated signaling pathway 0.238281877242333 0.0858217681147425 0.9316081018661202 1.0 1.0 36 Q99829,Q9Y5A9,Q96T37,P40763,Q6PD62 5 +Cell cycle dna replication 0.2476641545602975 0.0851222675837294 0.9321641875818982 1.0 1.0 17 P33991,P51530,P39748,Q92900,Q9BY42,P33993,P09884,O75312 8 +Positive regulation of mapk cascade 0.2406044845839528 0.085067066845514 0.93220807222409 1.0 1.0 32 Q9UMX5,P14174,Q99873,Q02952 4 +Dna repair 0.2239995708401634 0.0826322801314658 0.9341439332054816 1.0 1.0 138 Q9UQ84,P51530,Q9NXR7,Q92547,P43246,Q15645,Q9H4L7,Q9Y2K7,Q9BRT9,Q9NRR5,P54727,Q15014,Q9H1E3,P41440,Q9NW82,Q9C0B1,P46063,Q9NQ88,Q7Z4V5,P35637,Q9BXW9,P15927 22 +Nucleobase containing small molecule metabolic process 0.2328509724767039 0.0818500042210546 0.9347659918202278 1.0 1.0 159 Q9H773,Q13630,Q9BZX2,P34896,Q9NRF8,Q9UDY2,P43490,O95563,Q9UMR5,P55263,P61586,O00178,Q969T7,P36871 14 +Nadph regeneration 0.2587534247004212 0.0810551507951208 0.93539809275466 1.0 1.0 9 Q9NQ88,P11413 2 +Regulation of nucleocytoplasmic transport 0.2351636477549961 0.0808924831996133 0.9355274579134752 1.0 1.0 38 Q16630,P06493,Q13148,Q92688,Q9ULX6,Q08J23,Q00535,Q13263,O75312,O00410,Q07666,Q06124 12 +Vitamin d receptor signaling pathway 0.4480784955028744 0.0808865728911604 0.9355321582547194 1.0 1.0 2 Q15648 1 +Regulation of vitamin d receptor signaling pathway 0.4480784955028744 0.0808865728911604 0.9355321582547194 1.0 1.0 2 Q15648 1 +Negative regulation of ubiquitin protein transferase activity 0.2582721966708204 0.0801951908829792 0.9360820149639372 1.0 1.0 9 P61927 1 +Negative regulation of g protein coupled receptor signaling pathway 0.3461808392617894 0.0796986790320853 0.936476910092766 1.0 1.0 4 P16949 1 +Roof of mouth development 0.3461668839306971 0.0796807880683032 0.9364911397623088 1.0 1.0 4 Q92688 1 +Regulation of sodium ion transport 0.2534686152513207 0.0788991450993963 0.9371128432352416 1.0 1.0 10 O14745,P50570 2 +Collagen metabolic process 0.2899254577046183 0.078213221257934 0.9376584451926788 1.0 1.0 6 O60568 1 +Response to gamma radiation 0.2476236081037943 0.078097405259445 0.9377505711951516 1.0 1.0 15 Q9NQ88,Q9BXW9,P04179 3 +Telomere organization 0.2283014763001796 0.0778038265697368 0.9379841025163234 1.0 1.0 56 Q9UQ84,P41440 2 +Response to vitamin d 0.3437195788618641 0.0765845705667903 0.9389540338041438 1.0 1.0 4 Q14258 1 +Cell surface receptor signaling pathway involved in cell cell signaling 0.22999177535752 0.0765461582494884 0.9389845926956522 1.0 1.0 52 Q9UQB8,P20339,Q13526,Q15042,O14745,Q6PD62,P61586 7 +Neuroblast division 0.4282208588957082 0.0764719156789556 0.93904365657407 1.0 1.0 3 P61026,Q92974 2 +Asymmetric neuroblast division 0.4282208588957082 0.0764719156789556 0.93904365657407 1.0 1.0 3 P61026,Q92974 2 +Dephosphorylation of rna polymerase ii c terminal domain 0.4435813573180792 0.0760619807376212 0.939369787457639 1.0 1.0 2 Q9NQG5 1 +Homologous chromosome pairing at meiosis 0.2802649984345944 0.0753980221793977 0.9398980328044376 1.0 1.0 7 Q9BXW9 1 +Branching involved in blood vessel morphogenesis 0.3427562797091491 0.0753882817668318 0.9399057824728604 1.0 1.0 4 Q96T37 1 +Receptor internalization 0.2424804560596604 0.071685579610075 0.9428521324395736 1.0 1.0 17 P20339,P15311,P62993,P41440 4 +Regulation of striated muscle contraction 0.2446179557200258 0.0704871193460446 0.9438059523226764 1.0 1.0 11 P28161,P0DP25 2 +Translational termination 0.2646215947410205 0.0701705165880162 0.9440579408174192 1.0 1.0 8 Q8N543 1 +Cellular response to organic cyclic compound 0.2213850914219355 0.069531318600302 0.9445667043323536 1.0 1.0 92 P28161,P41440,P04083,O95831,O14745,Q9H7B4,P61586,O14744,Q02790 9 +Base excision repair gap filling 0.2759126710195962 0.068630635928796 0.9452836324080212 1.0 1.0 7 P39748,P27695 2 +Actin filament depolymerization 0.2393697439316508 0.0680347582768614 0.9457579652710364 1.0 1.0 18 Q9NYL9,P35241,Q9Y281 3 +Cellular response to leucine starvation 0.4192229038854835 0.0674026460068163 0.9462611627726212 1.0 1.0 3 Q92616,Q9P2J5 2 +Actin filament severing 0.2825296654399382 0.0672807926684348 0.9463581674667412 1.0 1.0 6 Q9Y281 1 +Positive regulation of protein polyubiquitination 0.4188139059304723 0.0670106781580773 0.9465732023689828 1.0 1.0 3 O75150,P61088 2 +Ruffle organization 0.2468419301360604 0.0669897984152335 0.946589824642571 1.0 1.0 10 Q9P258,P35241 2 +Regulation of cell cycle checkpoint 0.2426866747521131 0.066897833797165 0.9466630375566032 1.0 1.0 11 Q9Y6G9,P15927 2 +Mrna pseudouridine synthesis 0.4337694194603526 0.0663512846731511 0.9470981538824156 1.0 1.0 2 Q9Y606 1 +Negative regulation of axon extension 0.4178163538862119 0.0660619506564613 0.9473285036249328 1.0 1.0 3 Q00535 1 +Maintenance of protein localization in endoplasmic reticulum 0.4333605887162794 0.0659703810265418 0.9474014065852084 1.0 1.0 2 O15258 1 +Protein retention in er lumen 0.4333605887162794 0.0659703810265418 0.9474014065852084 1.0 1.0 2 O15258 1 +Positive regulation of sodium ion transmembrane transporter activity 0.3004502660663132 0.0658255608785321 0.9475167057275996 1.0 1.0 5 O43707,Q9UHD1,Q12955,P50570 4 +Cellular response to vitamin 0.3342880523731589 0.0654102362807282 0.9478473741617368 1.0 1.0 4 Q96C86,Q15648,Q13573 3 +Srp dependent cotranslational protein targeting to membrane signal sequence recognition 0.4321340964840687 0.0648388273655895 0.948302326709751 1.0 1.0 2 P09132 1 +Regulation of protein localization to chromatin 0.4317252657399967 0.06446534817464 0.9485996978486836 1.0 1.0 2 P06400 1 +Response to arsenite ion 0.4317252657399945 0.0644653481746378 0.9485996978486856 1.0 1.0 2 Q9H2U1 1 +Thymocyte apoptotic process 0.4155717259991336 0.0639647844709603 0.9489982672822356 1.0 1.0 3 O00273 1 +Tongue development 0.4155419222903852 0.0639372872623032 0.949020162062755 1.0 1.0 3 Q92769,Q13547 2 +Hair follicle placode formation 0.4155419222903852 0.0639372872623032 0.949020162062755 1.0 1.0 3 Q92769,Q13547 2 +Fungiform papilla development 0.4155419222903852 0.0639372872623032 0.949020162062755 1.0 1.0 3 Q92769,Q13547 2 +Fungiform papilla morphogenesis 0.4155419222903852 0.0639372872623032 0.949020162062755 1.0 1.0 3 Q92769,Q13547 2 +Tongue morphogenesis 0.4155419222903852 0.0639372872623032 0.949020162062755 1.0 1.0 3 Q92769,Q13547 2 +Synaptic vesicle budding 0.4151329243353797 0.0635608605826884 0.9493198974237932 1.0 1.0 3 O00203,Q13492 2 +Aldehyde biosynthetic process 0.4292722812755646 0.0622630874751413 0.9503533233456852 1.0 1.0 2 P60174 1 +Glutamine metabolic process 0.2408608333521119 0.0617054058967113 0.9507974348925484 1.0 1.0 13 Q05682,Q9NRF8,O15067,P17812 4 +Regulation of mitochondrial membrane potential 0.2383632335185217 0.0616562222990352 0.9508366031466048 1.0 1.0 17 Q8IWA4,Q8N0X7,P48506,P04179 4 +Response to isoquinoline alkaloid 0.4114519427402887 0.060249627571198 0.951956820388436 1.0 1.0 3 P63151,P06744 2 +Minus end directed organelle transport along microtubule 0.4264104660670573 0.0597765465139885 0.9523336053363944 1.0 1.0 2 Q14204 1 +Epithelial cell cell adhesion 0.3289689034369891 0.059628217511156 0.9524517440245795 1.0 1.0 4 P35221,P18206,P14923 3 +Negative regulation of ubiquitin dependent protein catabolic process 0.2325923210697344 0.0592405459841225 0.9527605153079348 1.0 1.0 21 Q9H2J4 1 +Regulation of amyloid precursor protein catabolic process 0.241829610503223 0.0586708452097357 0.953214281473998 1.0 1.0 10 Q13526,P27695 2 +Homologous chromosome segregation 0.2552402799142386 0.0561388847338495 0.955231167228716 1.0 1.0 8 Q9BXW9 1 +S adenosylmethionine metabolic process 0.4044989775051119 0.0543646408465881 0.9566446496914728 1.0 1.0 3 P31153,P23526 2 +Positive regulation of protein k63 linked ubiquitination 0.4186426819296922 0.0534650961283929 0.9573613401098836 1.0 1.0 2 P61088 1 +Regulation of response to biotic stimulus 0.2233455569170453 0.0530477586202607 0.9576938553796144 1.0 1.0 57 P14174,Q9Y5A9,O60828,P19474,Q96J02 5 +Hindlimb morphogenesis 0.4153720359771165 0.0509934788455574 0.9593307169167808 1.0 1.0 2 Q15648 1 +Embryonic hindlimb morphogenesis 0.4153720359771165 0.0509934788455574 0.9593307169167808 1.0 1.0 2 Q15648 1 +Regulation of core promoter binding 0.4153720359771132 0.0509934788455549 0.9593307169167828 1.0 1.0 2 Q12948 1 +Ectoderm development 0.4153720359771128 0.0509934788455546 0.9593307169167832 1.0 1.0 2 P13693 1 +Positive regulation of hematopoietic progenitor cell differentiation 0.4000000000000021 0.0508075841966415 0.959478847369591 1.0 1.0 3 Q12948,Q9H2U1 2 +Regulation of deoxyribonuclease activity 0.2871197364475037 0.0501667039128319 0.9599895445584632 1.0 1.0 5 O00273,P09429 2 +Positive regulation of cell projection organization 0.2251934244353781 0.0498811195256506 0.9602171230076026 1.0 1.0 42 Q15555,Q9UQB8,Q9H4M9,Q15428,P27695,P78344,Q8NCA5,Q9NQW6,O14786,O15144,P50570,Q92766 12 +Positive regulation of organelle organization 0.2110592923113541 0.0497855542333226 0.9602932784593824 1.0 1.0 120 Q9UHV9,Q9UQB8,Q14203,P04083,Q99549,O14786,O15144,Q9UJX4,P61586,P11233,P30260,Q15555,Q14247,P62993,Q8WUM4,Q15021,Q96QK1,P35609,Q96A26,Q9Y281,P49257,P39748,O14737,Q9NTJ3,Q15042,P60953,P27695,Q9BVK6,Q15691,Q9UJX2,Q07812,Q00535,Q13263,P12235,P22626 35 +Negative regulation of guanyl nucleotide exchange factor activity 0.3972874927963429 0.048755751877066 0.9611139450950724 1.0 1.0 3 P16949 1 +Cardiac cell development 0.2348491327971925 0.0480529336895139 0.9616740563151563 1.0 1.0 10 Q15149,P11413,P35609,Q96HC4 4 +Erbb2 signaling pathway 0.3957450582624072 0.0476195971749009 0.9620194134591536 1.0 1.0 3 Q93034 1 +Exocrine system development 0.2840312107236468 0.0469150888805519 0.9625809021486008 1.0 1.0 5 O14786 1 +Neuroepithelial cell differentiation 0.3946830265848666 0.0468500619289885 0.96263272916071 1.0 1.0 3 P07437,Q9P287 2 +Protein insertion into membrane 0.2269357495881388 0.0464829600766714 0.9629253152940932 1.0 1.0 20 Q9NPA0,P07900,P30419,Q9Y512,Q8N766,O43402,Q15006,Q8WWC4,P34932,Q96A33,P61619,P46379,Q5J8M3,O14737,Q9NS69,O43681,O43765,Q53H12,Q07812 19 +Substrate dependent cell migration 0.2822803518504862 0.0451327858152051 0.9640014687382148 1.0 1.0 5 O14786,Q9Y5K6 2 +Response to virus 0.2156698762156576 0.0430118742989328 0.9656920682926128 1.0 1.0 74 P04792 1 +Regulation of microtubule based process 0.2244691130095912 0.0427196053387705 0.9659250510347503 1.0 1.0 48 O43633,Q15555,P27695,Q14203,Q15691,P61586,Q02790 7 +Cellular response to muramyl dipeptide 0.3877300613496974 0.0420638605422634 0.9664477897670942 1.0 1.0 3 P08670,Q92974 2 +Intermediate filament based process 0.2441163096450571 0.0417303015290526 0.9667136978672328 1.0 1.0 8 P07197,P58107,P08670,Q15149 4 +Establishment or maintenance of cytoskeleton polarity 0.3097381342062204 0.0416980033477512 0.9667394456761846 1.0 1.0 4 Q14008,O00151,P02545 3 +Negative regulation of actin filament polymerization 0.2289143113087401 0.0403641271638489 0.9678028293048636 1.0 1.0 16 Q9NYL9,Q9NUQ9 2 +Positive regulation of transcription of nucleolar large rrna by rna polymerase i 0.2544039328144201 0.0402623024597736 0.9678840076735832 1.0 1.0 7 Q13610,P56192,P19338,Q9H8H0,P42345,Q12824 6 +Voluntary musculoskeletal movement 0.3848670756646168 0.0402170424222637 0.9679200907334928 1.0 1.0 3 Q96QK1,P42345 2 +Regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.2542847717582077 0.0401278320768381 0.9679912128782504 1.0 1.0 7 P35221,Q86WB0,P30153 3 +Regulation of apoptotic signaling pathway 0.2164992158865553 0.0400420130823387 0.9680596315392906 1.0 1.0 78 Q86WB0,P14174,Q9H3K2,P16989,P04792,P04179,O14745 7 +Protein targeting to membrane 0.2265838757947243 0.0394430866018946 0.96853712847891 1.0 1.0 22 Q9NT62,Q9UHB9,O76094 3 +Regulation of protein polyubiquitination 0.2596232596232546 0.0393090019415615 0.9686440296533336 1.0 1.0 6 P61088,Q96FW1,O00571,O75150,O95071 5 +Histone h2a ubiquitination 0.2596232596232541 0.0393090019415609 0.968644029653334 1.0 1.0 6 Q13620,P63208,Q96FW1,Q16531,O95071 5 +Histone h3 k9 demethylation 0.3832310838445818 0.0391933351259958 0.9687362473544554 1.0 1.0 3 Q9UPP1,Q7LBC6 2 +Positive regulation of neural precursor cell proliferation 0.3832310838445777 0.0391933351259933 0.9687362473544574 1.0 1.0 3 P55209,P35222 2 +Fatty acid derivative catabolic process 0.3054588578727795 0.0383091862543337 0.9694411665923316 1.0 1.0 4 O95372 1 +Rescue of stalled ribosome 0.3815950920245329 0.0381922842281692 0.9695343727033308 1.0 1.0 3 Q15650,P63244 2 +Intracellular protein transport 0.2433901154926695 0.03813705661981 0.9695784058795982 1.0 1.0 242 Q9NT62,Q8TEX9,P61009,P04792,Q7Z4Q2,Q92973,O76094,P20645,O60749,Q15904,Q9BUN8,O60830,Q06124,O75340,Q8TAG9,P40616,Q9BW83,Q9Y5X3,P35606,Q9H4M9,Q92688,O95831,O14737,Q9H6Z4,Q9BXS5,P83436,Q96AX1,P27695,P20339,Q13148,Q9BVK6,P40763,Q00535,O43592,P55786,Q9UHB9,Q15436,O60684 38 +Positive regulation of rrna processing 0.2746623004502675 0.0378796920200984 0.9697836048471348 1.0 1.0 5 Q8TED0,Q15061,Q9UNQ2,Q8IWA0 4 +Nls bearing protein import into nucleus 0.2273044853051526 0.0378061470297137 0.9698422432567988 1.0 1.0 10 O00410,Q14974,O60684 3 +Telomere maintenance via semi conservative replication 0.257601636675649 0.0372480860606342 0.9702871980604392 1.0 1.0 6 P51530,Q92900 2 +Regulation of transport 0.2433066967172189 0.0371483373985149 0.9703667309337378 1.0 1.0 232 Q9NT62,P02656,Q7Z3T8,O43633,P48506,P04083,Q8N6T3,O14786,Q08J23,P61586,P11233,P33176,Q06124,P14174,O43768,Q04917,Q99439,Q9Y376,O60343,P30626,P35241,Q8IWJ2,Q9Y5X3,O95563,P54652,P53680,P35609,P15311,P31689,P55011,P41440,P49257,Q9H4M9,Q99816,P61978,Q92688,P07384,Q96KC8,Q9H223,O14737,Q6ZWJ1,Q15042,Q9H3U1,P60953,O14745,P35580,P50570,O75592,Q9Y5K6,Q6IAA8,O43747,Q16630,P11413,P27695,P20339,Q13148,Q9UN37,Q9ULX6,P17858,P17931,P0DP25,Q00535,Q13263,Q07812,P55786,P28161,O75312,Q07666 68 +Regulation of lamellipodium assembly 0.2240459581452545 0.0370270016680747 0.9704634762804036 1.0 1.0 11 O94813,P60953,Q16658,Q7L576,P42345,Q9Y2A7,O15144,P50570,P47756,Q12792 10 +Cytoplasmic sequestering of transcription factor 0.3022877664400682 0.0359312411128469 0.971337185138956 1.0 1.0 4 P30626 1 +Embryonic viscerocranium morphogenesis 0.3912510220768675 0.0358916562908675 0.9713687488978712 1.0 1.0 2 P11586 1 +Embryonic neurocranium morphogenesis 0.3912510220768675 0.0358916562908675 0.9713687488978712 1.0 1.0 2 P11586 1 +Positive regulation of telomere capping 0.3770961145194287 0.0355539780121911 0.9716380053251346 1.0 1.0 3 P27361,Q14103 2 +Thyroid gland development 0.3770961145194259 0.0355539780121897 0.9716380053251356 1.0 1.0 3 P27361,Q02750 2 +Histone h4 k20 methylation 0.3011456628477908 0.0351020211464864 0.971998389765116 1.0 1.0 4 Q13610,P38398,Q14166 3 +Protein targeting 0.2162581366293266 0.0342285263302469 0.9726949191419224 1.0 1.0 81 Q9NT62,P61009,P20645,O95831,P55786,O60830 6 +Positive regulation of dna ligation 0.3847097301717194 0.0326607288823049 0.973945140983052 1.0 1.0 2 P09429 1 +Regulation of dna ligation 0.3847097301717194 0.0326607288823049 0.973945140983052 1.0 1.0 2 P09429 1 +Replication born double strand break repair via sister chromatid exchange 0.3847097301717149 0.0326607288823026 0.9739451409830536 1.0 1.0 2 O60216 1 +Lamellipodium assembly 0.2243221035332783 0.0323016514394058 0.974231492235234 1.0 1.0 14 O94813,P60953,Q16658,Q7L576,P42345,Q9Y2A7,P18206,O15144,Q9BW27,P50570,P47756,Q12792,P05556 13 +Ribosome associated ubiquitin dependent protein catabolic process 0.3814390842191433 0.0311696690067621 0.9751342287821676 1.0 1.0 2 Q15650 1 +Negative regulation of wnt signaling pathway 0.2228175781859092 0.0299814614385595 0.9760818381531012 1.0 1.0 14 O14745 1 +Trna transport 0.2646035896646671 0.0295016585072897 0.9764644962210038 1.0 1.0 5 O43592 1 +Udp glucose metabolic process 0.375306623058061 0.0285855598937975 0.9771951289146008 1.0 1.0 2 Q9NYU2 1 +Response to amino acid starvation 0.2174805088223164 0.0284807568253123 0.9772787156322132 1.0 1.0 11 P27361,Q6PKG0,Q9P2J5,P49327,P42345,P28482,P05198,P19525,Q92616,Q9BY44 10 +Cytoskeleton dependent cytokinesis 0.2260954600378823 0.0279307266690642 0.977717401660244 1.0 1.0 34 O43633,Q9NVA2,Q8WUM4,Q9UN37,P16949,Q9NQW6,O75935,P35580,Q15149,P61586,Q6DKK2 11 +Vesicle cytoskeletal trafficking 0.2214461791290069 0.0279188121356232 0.9777269043767284 1.0 1.0 14 O43795,Q9Y2T2,O43707,Q14204,P27695,O14617,O00203,Q12756,Q9UM54,Q92572,O94832,P33176,O00159 13 +Liver morphogenesis 0.3620208138292445 0.0278716025941771 0.9777645574883722 1.0 1.0 3 Q15418 1 +Rab protein signal transduction 0.3728536385936318 0.0276259741032828 0.9779604652299212 1.0 1.0 2 P31150 1 +Regulation of binding 0.2142801468539719 0.0263258571635956 0.9789974310216653 1.0 1.0 78 P60228,P16949,P19474,Q7L2J0,Q04637,Q9BUN8,Q8TEY7,P30626,Q86X55,Q13526,Q9H1E3,P41440,P05198,Q99829,Q15691,P0DP25,O60869,Q00535,Q07812 19 +Homocysteine metabolic process 0.3583764337960964 0.0262649038141474 0.9790460479471912 1.0 1.0 3 Q13867 1 +Regulation of protein k63 linked ubiquitination 0.259516987310685 0.0257563204407801 0.9794517015182436 1.0 1.0 5 Q96FW1,P61088,O95071,O00571 4 +Regulation of biomineralization 0.2864157119476285 0.0256368560670058 0.9795469888325888 1.0 1.0 4 Q9NUQ3,Q13464,P20020 3 +Regulation of mitotic sister chromatid segregation 0.2201743379922441 0.025185001256328 0.9799074004262625 1.0 1.0 15 P14635,Q15645,P12270,Q9Y6G9,O43264,O43683,O43684 7 +Regulation of nadp metabolic process 0.2844046217042233 0.0245128580987013 0.980443527517728 1.0 1.0 4 Q9NQ88 1 +Viral genome replication 0.2205393297028202 0.0243821135874755 0.9805478153745528 1.0 1.0 45 Q13363,Q9H1E3,P20339,Q13325,Q15075 5 +Positive regulation of attachment of spindle microtubules to kinetochore 0.3471630288192185 0.0218776500023921 0.9825455532224248 1.0 1.0 3 Q9P258 1 +Positive regulation of nucleobase containing compound transport 0.3453376908093595 0.0212385404729802 0.9830553703570326 1.0 1.0 3 Q07666 1 +Positive regulation of rna export from nucleus 0.3453376908093595 0.0212385404729802 0.9830553703570326 1.0 1.0 3 Q07666 1 +Pteridine containing compound biosynthetic process 0.2391482391482347 0.0212344631539386 0.9830586228534426 1.0 1.0 6 P22102,P31939,P00374,Q6UB35,P11586 5 +Negative regulation of extrinsic apoptotic signaling pathway 0.2181590263403871 0.0204051393446685 0.9837201841007388 1.0 1.0 18 P17931,O14786,Q86WB0,P48506 4 +Vesicle fusion with golgi apparatus 0.3475061324611694 0.0198832908359852 0.984136474492489 1.0 1.0 2 O60763 1 +Ventricular cardiac muscle cell differentiation 0.3466884709730249 0.0196918848241116 0.984289164498267 1.0 1.0 2 P06493 1 +Ventricular cardiac muscle cell development 0.3466884709730249 0.0196918848241116 0.984289164498267 1.0 1.0 2 P06493 1 +Regulation of cd8 positive alpha beta t cell activation 0.3462796402289524 0.0195973886002376 0.9843645470294164 1.0 1.0 2 Q13951 1 +Positive regulation of cd8 positive alpha beta t cell activation 0.3462796402289524 0.0195973886002376 0.9843645470294164 1.0 1.0 2 Q13951 1 +Cd8 positive alpha beta t cell activation 0.3462796402289524 0.0195973886002376 0.9843645470294164 1.0 1.0 2 Q13951 1 +Calcium ion transmembrane transport 0.2235138657259949 0.0181620514330133 0.98550957620894 1.0 1.0 31 P11413,P27695,P30626,P0DP25,Q00535,P54652,P28161,Q93034 8 +Negative regulation of proteolysis involved in cellular protein catabolic process 0.2194137339810778 0.0178133835552896 0.9857877279212716 1.0 1.0 23 Q9H2J4,P46379,Q96KB5,Q04323,P46777,O15372,Q92530 7 +Cellular response to vitamin d 0.3341513292433515 0.0177417107736998 0.9858449054911724 1.0 1.0 3 Q15648,Q13573 2 +Cellular extravasation 0.2692307692307732 0.0172095574836884 0.986269437549719 1.0 1.0 4 Q9Y624,Q13464,P46109 3 +Protein localization to cytoplasmic stress granule 0.2453066607793867 0.0169014784638375 0.9865152132926556 1.0 1.0 5 Q92499,P67809 2 +Regulation of camp dependent protein kinase activity 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 +Negative regulation of camp dependent protein kinase activity 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 +Axis elongation 0.3272279482141706 0.0159117977172199 0.9873047579771964 1.0 1.0 3 Q13263 1 +Epithelial cell differentiation 0.2136477261284289 0.0151985835233565 0.987873751716815 1.0 1.0 84 Q8WX93,Q13247,P80723,P09960,P11047,Q9UDY2,P04083,O60568,O14745,P61586 10 +Cytoplasmic sequestering of protein 0.2265464973371564 0.0149914917327961 0.9880389682346736 1.0 1.0 7 P21333,P31946,P30626,Q16643,Q9UNN5,Q9UN86 6 +Histone h3 k9 methylation 0.2054963084495533 0.0148331217544288 0.9881653151460776 1.0 1.0 10 Q9H9B1,O60341,P26358,P38398,P02545,Q12824,Q96KQ7,Q15047,Q5UIP0 9 +Synaptic vesicle uncoating 0.3037612428454704 0.0132964336340426 0.9893912934852171 1.0 1.0 2 Q99961 1 +Response to hydroxyurea 0.2270520172951694 0.0132444573964949 0.9894327608712185 1.0 1.0 6 Q9BY42,Q5TDH0 2 +Protein o linked fucosylation 0.2955846279640315 0.0126802855222823 0.9898828670776204 1.0 1.0 2 Q9Y2G5 1 +Fucosylation 0.2955846279640315 0.0126802855222823 0.9898828670776204 1.0 1.0 2 Q9Y2G5 1 +Apoptotic process involved in development 0.2259400242388609 0.0125999729324532 0.9899469421341336 1.0 1.0 6 O75312 1 +Growth 0.210507167401225 0.0122215324130479 0.9902488707265076 1.0 1.0 127 Q16555,Q7Z6E9,P30153,P80723,P78344,P04083,O14786,Q9Y3A5,Q15149,O95470,P61586,Q04637,Q06124,P31150,O60271,Q14247,P10644,Q96HC4,Q9BRT9,Q96MG7,P61201,Q6PD62,Q14353,Q9Y696,Q15014,P15311,P16989,Q99816,Q9C0B1,P60953,P50570,Q6Y7W6,Q6IAA8,Q7Z4V5,Q99829,P11413,Q15418,O95684,P11047,Q13177,Q8N0X7,P18206,P40763,O00763,Q00535,Q13263,P11802,O75312,Q8IYB8,Q96J02 50 +Regulation of translation at synapse modulating synaptic transmission 0.2553191489361712 0.0121442739387437 0.9903105094958516 1.0 1.0 4 Q7L576,P35268,P06730 3 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.2553191489361703 0.0121442739387434 0.9903105094958518 1.0 1.0 4 Q99729,Q9Y5S9,P11940 3 +Sensory system development 0.2193704763377119 0.0120184604830449 0.9904108867838552 1.0 1.0 27 Q15555,P11047,O14786,P40763,Q15042,Q07812,Q99471 7 +Cardiac conduction system development 0.2812755519215135 0.0118946967863197 0.990509628868272 1.0 1.0 2 P60953 1 +Positive regulation of protein import 0.2112061499538359 0.0115429863690615 0.9907902339100478 1.0 1.0 16 Q13148,O14737,Q13263,O75312,O00410 5 +Endothelin receptor signaling pathway 0.2718724448078589 0.0115368021195023 0.9907951678987528 1.0 1.0 2 P60953 1 +Positive regulation of transferase activity 0.2098766428679645 0.0113563746377456 0.9909391187697496 1.0 1.0 73 Q99627,P14174,Q9Y376,Q16763,Q13526,Q9BRT9,Q96A49,P0DP25,Q9NQ88,P61586 10 +Protein export from nucleus 0.2137779303000234 0.0109352478646042 0.9912751084472 1.0 1.0 21 Q9H6Z4,Q92688,Q06124 3 +Lens development in camera type eye 0.2471358428805247 0.009787812720828 0.9921905800382892 1.0 1.0 4 P08670,Q15648,P35222 3 +Embryonic appendage morphogenesis 0.2205496330876017 0.0096763559601591 0.992279505455461 1.0 1.0 6 Q13547,Q07812 2 +Spindle assembly 0.2167788711548823 0.0094276732717249 0.9924779164807752 1.0 1.0 43 Q15691,P61586 2 +Regulation of bone mineralization 0.2862985685071505 0.0091238242897168 0.9927203424620714 1.0 1.0 3 Q9NUQ3,P20020 2 +Kinetochore organization 0.2778449235225837 0.0083619864523975 0.99332817786418 1.0 1.0 3 Q9NTJ3 1 +Negative regulation of muscle cell differentiation 0.2053278688524635 0.0082679679893103 0.9934031911510692 1.0 1.0 8 O75179,P11413,P26358,O94826,Q13547,P67809,P26599 7 +Rna destabilization 0.220102556288729 0.0082675562082121 0.9934035196936208 1.0 1.0 36 Q9Y5A9,Q92945,Q13148,Q92900,Q9C0B1,Q9Y2L1,Q6Y7W6,Q969T7 8 +Negative regulation of protein k63 linked ubiquitination 0.2593047034764745 0.0071899544078932 0.99426329581202 1.0 1.0 3 Q96FW1,O95071 2 +Negative regulation of protein polyubiquitination 0.2593047034764745 0.0071899544078932 0.99426329581202 1.0 1.0 3 Q96FW1,O95071 2 +Histone h2a k63 linked ubiquitination 0.2593047034764745 0.0071899544078932 0.99426329581202 1.0 1.0 3 Q96FW1,O95071 2 +Histone mrna catabolic process 0.2230863692181756 0.0071707126985124 0.9942786480790932 1.0 1.0 5 Q8IV48,Q9NVV4,Q92900,P05455 4 +Postsynaptic modulation of chemical synaptic transmission 0.2552147239263716 0.0070052326411892 0.994410678745192 1.0 1.0 3 Q7L576,P06730 2 +Cell morphogenesis 0.2145291756413382 0.0065878118936722 0.9947437246203414 1.0 1.0 136 Q9UQB8,Q9Y624,O60828,P78344,P04083,O60749,P16949,O14786,O15144,P61586,P33176,Q06124,P35579,Q8TEY7,Q8WX93,Q04917,Q01518,Q14247,O60271,P35241,O60568,Q9UPY3,O95372,P15311,P41440,Q9BTW9,P35613,O14745,P50570,Q9P258,O60678,O75592,Q92766,Q99829,Q9Y5A9,P11047,Q8N0X7,Q00535,Q96AX1 39 +Regulation of wound healing spreading of epidermal cells 0.2314134195372453 0.0063391291092953 0.9949421406294204 1.0 1.0 4 Q92766 1 +Wound healing spreading of epidermal cells 0.2314134195372453 0.0063391291092953 0.9949421406294204 1.0 1.0 4 Q92766 1 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.2087816721584682 0.0046751927068144 0.9962697495094056 1.0 1.0 20 P35606,P18085,P48739,Q9UBF2,Q9Y282,P83436,P61923,P53621 8 +Cell cell signaling by wnt 0.2162688070325673 0.0046016086128451 0.9963284604903117 1.0 1.0 46 P20339,Q13526,O14745,Q6PD62,P61586 5 +Dna strand elongation 0.2079437190277717 0.0045932692048638 0.9963351143048668 1.0 1.0 17 Q9H1E3,P33991,P51530,Q07864,Q9Y5K5,P33993,P09884 7 +Positive regulation of protein secretion 0.2087547789759619 0.0041555674037758 0.9966843464700144 1.0 1.0 18 P15311,P30626,O95563,Q96QK1,P35580,Q9Y5K6 6 +Neuron projection extension 0.216604183678679 0.0040364105079443 0.9967794191199292 1.0 1.0 27 Q99829,O60271,Q14247,Q16555,P11047,P78344,O14786,P18206,Q00535,P50570 10 +Protein containing complex disassembly 0.210120700907137 0.0039450019781942 0.9968523519937598 1.0 1.0 77 O43633,Q8N543,Q9NYL9,P17096,Q9Y281,Q99816,Q9UN37,P35241,Q92900,Q99570,P16949,Q08945,Q9NRR5,Q12824,Q96AX1,O95104,P35609,Q01105 18 +Barbed end actin filament capping 0.1836818368183712 0.0025751525849928 0.9979453277816188 1.0 1.0 9 P35241,P52907,P47755,P35611,Q9UEY8,P47756,Q12792,Q9BPX3 8 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..1e499fbd9187bf696f0d80f933d2ad2a39f895bb --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in blood vessel morphogenesis", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Arterial endothelial cell differentiation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in cardiac muscle cell fate commitment", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac cell fate commitment", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell fate commitment", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell myoblast differentiation", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cocaine", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal aorta development", "Dorsal aorta morphogenesis", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Endocannabinoid signaling pathway", "Endocardial cushion development", "Endocardial cushion formation", "Endocardial cushion morphogenesis", "Endocardium development", "Endocardium morphogenesis", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial to mesenchymal transition involved in endocardial cushion formation", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled opioid receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart field specification", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 demethylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid catabolic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell fate commitment", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary transport", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learning", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene d4 metabolic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell fate commitment", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid dendritic cell differentiation", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of sterol transport", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of triglyceride catabolic process", "Negative regulation of triglyceride metabolic process", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron fate specification", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nitrogen utilization", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling involved in heart development", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid efflux", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic dna fragmentation", "Positive regulation of apoptotic process involved in development", "Positive regulation of apoptotic process involved in morphogenesis", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell proliferation involved in heart morphogenesis", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental pigmentation", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna catabolic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic animal organ morphogenesis", "Post embryonic camera type eye development", "Post embryonic development", "Post embryonic eye morphogenesis", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of development heterochronic", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high density lipoprotein particle clearance", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snare complex assembly", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription from rna polymerase ii promoter involved in heart development", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of very low density lipoprotein particle remodeling", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wnt signaling pathway involved in heart development", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Resolution of recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell programmed cell death", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Sebaceous gland development", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary heart field specification", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Triglyceride rich lipoprotein particle clearance", "Triglyceride rich lipoprotein particle remodeling", "Tripartite regional subdivision", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Urogenital system development", "Uronic acid metabolic process", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Vagina development", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C19orf70", "C1QBP", "C2orf49", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAM162A", "FAM208A", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GHITM", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL24", "MRPL28", "MRPL37", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NEK9", "NELFA", "NELFB", "NENF", "NEO1", "NEU1", "NFS1", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2B", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG2", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF2", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC37", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAR2", "AASDHPPT", "ABRAXAS2", "ACACB", "ACP6", "ACTN1", "ACTN2", "ACTN4", "ADD1", "ADD3", "ADK", "ADSL", "ADSS", "AGK", "AHCY", "AIFM1", "AIMP2", "AK1", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALDH1B1", "ALG5", "ALKBH5", "ANAPC5", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANXA1", "ANXA11", "AP1B1", "AP1G1", "AP1M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOC3", "APOL2", "APRT", "ARF4", "ARFGAP1", "ARHGDIA", "ARHGEF2", "ARIH1", "ARL1", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC4", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1B3", "ATP2B1", "ATP6AP1", "ATP6V1B2", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BAX", "BCCIP", "BLMH", "BPNT1", "BRCA1", "BSG", "BTF3", "BUB1", "BUB3", "BZW2", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CAST", "CBFB", "CCDC124", "CCDC47", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CERS2", "CFL2", "CHAF1B", "CHD1", "CHMP2A", "CHORDC1", "CIAPIN1", "CIRBP", "CKAP2", "CKAP5", "CLASP1", "CLIC4", "CLNS1A", "CLPP", "CLTA", "CLTB", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "COG7", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS5", "COPS7A", "COPS8", "COPZ1", "COTL1", "CPNE1", "CPSF6", "CPSF7", "CRKL", "CRTAP", "CSDE1", "CTBP1", "CTNNA1", "CTNNB1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL3", "CUL4B", "CUL5", "CUTA", "CYB5D2", "CYFIP1", "DAZAP1", "DBN1", "DCAF8", "DCD", "DCPS", "DCTN1", "DCTN3", "DCTPP1", "DDB1", "DDI2", "DDT", "DDX1", "DDX20", "DDX3X", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX29", "DHX30", "DHX33", "DHX36", "DIABLO", "DICER1", "DIMT1", "DIS3", "DKC1", "DNA2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC3", "DNAJC9", "DNM2", "DNMT1", "DNPH1", "DPF2", "DPP9", "DPYSL2", "DST", "DUSP3", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "EDF1", "EEA1", "EEF1B2", "EEF1D", "EEF1E1", "EFHD1", "EFL1", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3H", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EML4", "ENSA", "EPB41", "EPDR1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERGIC3", "ERI1", "EXO1", "EXOC5", "EXOC6", "EZR", "F11R", "FAF1", "FAM162A", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FASN", "FDXR", "FEN1", "FGFR1OP", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLNA", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FUBP1", "FUS", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAMT", "GAPDH", "GART", "GATAD2B", "GBF1", "GCC2", "GCLC", "GCN1", "GDI1", "GDI2", "GGCX", "GGT7", "GHITM", "GIGYF2", "GINS4", "GMPS", "GOLGA2", "GOLGB1", "GPI", "GPS1", "GRB2", "GSTM2", "GSTO1", "GTF3C5", "GTPBP1", "GYS1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HEATR1", "HEATR3", "HECTD1", "HLCS", "HMGA1", "HMGB1", "HMGB3", "HMGN2", "HNRNPA2B1", "HNRNPAB", "HNRNPD", "HNRNPK", "HPRT1", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA2", "HSPA4", "HSPB1", "HTATSF1", "HUWE1", "IDH1", "IDH2", "IFIT5", "IFT27", "IMPDH2", "INTS13", "IPO4", "IPO5", "IPO7", "ITCH", "ITGB1", "JUP", "KCTD5", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF18A", "KIF1A", "KIF5B", "KIFBP", "KPNA6", "KPNB1", "LAMC1", "LAMTOR1", "LARP1", "LARP7", "LARS", "LDAH", "LDHA", "LEMD3", "LGALS3", "LIG3", "LMAN1", "LMNA", "LNPEP", "LONP1", "LSM6", "LTA4H", "LYAR", "LYPLA2", "M6PR", "MAGED2", "MAIP1", "MANF", "MAP2K1", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARCKS", "MARS", "MAT2A", "MBD3", "MCM2", "MCM3", "MCM4", "MCM7", "MED1", "MED23", "MEPCE", "METTL13", "MFN1", "MFSD5", "MGEA5", "MIA3", "MIF", "MINDY3", "MINPP1", "MORF4L2", "MPC2", "MPDU1", "MPHOSPH8", "MPP6", "MPST", "MPV17L2", "MSH2", "MSH6", "MSN", "MSTO1", "MTAP", "MTHFD1", "MTHFD1L", "MTOR", "MTPAP", "MTR", "MYCBP2", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NCAPD2", "NCAPG", "NCKAP1", "NCL", "NDUFA7", "NECAP2", "NEFM", "NELFA", "NELFB", "NENF", "NISCH", "NLE1", "NME2", "NMT1", "NOL11", "NOSIP", "NPEPPS", "NRDC", "NRP1", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDT21", "NUMA1", "NUP133", "NUP37", "NUP85", "NUP93", "NXN", "OGFOD1", "OSBP", "OSBPL9", "OTUB1", "P4HA2", "PABPC1", "PABPC4", "PAF1", "PAICS", "PAK2", "PALLD", "PARP1", "PBK", "PCYOX1", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDLIM1", "PDLIM5", "PDS5A", "PEF1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PGAM1", "PGM1", "PGM3", "PHAX", "PHF8", "PHGDH", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PITPNA", "PITPNB", "PLEC", "PLIN3", "PLK1", "PLOD3", "PLRG1", "PNP", "POFUT2", "POLA1", "POLE", "PPAT", "PPIL1", "PPIL3", "PPM1G", "PPP2R1A", "PPP2R2A", "PPT2", "PQBP1", "PRCC", "PRIM1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPS2", "PRPSAP2", "PRRC2C", "PSMA2", "PSMA4", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD1", "PSMD11", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSMF1", "PSMG1", "PSPC1", "PTBP1", "PTGES3", "PTPA", "PTPN11", "PUM1", "PUS1", "PWP1", "PXMP2", "PYGL", "QKI", "RAB10", "RAB3GAP1", "RAB5A", "RACK1", "RAD21", "RAD23B", "RALA", "RANBP1", "RANBP3", "RANBP9", "RB1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM19", "RBM3", "RBM8A", "RBMX", "RCC2", "RDX", "RECQL", "REPS1", "RER1", "RHOA", "RIDA", "RIF1", "RNASEH2B", "RNF20", "RNF40", "ROCK1", "RPA1", "RPA2", "RPF2", "RPL19", "RPL22", "RPL36A", "RPL37", "RPL38", "RPL5", "RPLP2", "RPRD1B", "RPS19", "RPS3", "RPS6KA1", "RREB1", "RRM1", "RRM2", "RRP8", "RTFDC1", "S100A11", "S100A13", "SAMM50", "SAP18", "SARS", "SART3", "SBDS", "SCAF11", "SCAF4", "SCFD1", "SCPEP1", "SEC22B", "SEC23A", "SEC61A1", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SET", "SETD1A", "SETDB1", "SF1", "SF3A2", "SF3B4", "SFSWAP", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHOC2", "SIGMAR1", "SKP1", "SLC12A2", "SLC19A1", "SLC25A17", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A4", "SLC33A1", "SLC9A3R1", "SLFN11", "SLIT2", "SMARCAD1", "SMARCB1", "SMC2", "SMC4", "SMN1*", "SMYD3", "SNAP29", "SNW1", "SNX1", "SNX2", "SNX3", "SNX5", "SOD2", "SPAG9", "SPART", "SPCS3", "SPTBN1", "SRI", "SRP19", "SRP68", "SRP72", "SRPK2", "SRSF12", "SRSF6", "SSB", "SSRP1", "STAG2", "STAT3", "STAU1", "STMN1", "STRAP", "STUB1", "STX7", "STXBP4", "SUB1", "SUPT5H", "SUPV3L1", "SYAP1", "TAF15", "TARDBP", "TARS", "TBC1D15", "TBC1D4", "TBCD", "TBCE", "TCAF1", "TCERG1", "TCP1", "TFG", "THG1L", "THRAP3", "THUMPD3", "TIGAR", 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59.86893203883495 0.5096924099132711 0.6119855012565802 7.368712981381447 4.1374803346545495 1.0677911950970993 0.3642445397432887 1.0 0.2383836022925792 0.000634954959964 0.000169470417534 3.04520280498427e-08 +Intracellular protein containing complex 86 185 2.908157648320002 0.0036356500824041 65.0 234.75242718446603 -0.2941332188079113 0.6477973480500141 24.241202988508988 28.5911397255829 0.9105455330930315 0.3287777591778181 1.0 0.8681852806628976 0.0108714948182556 0.0546795434709234 0.0007580501674929 +Ubiquitin ligase complex 19 43 2.5111287362389025 0.012034580035602 15.37135922330097 61.429611650485434 -0.0248059945812641 0.7068340308999228 6.472905073787162 10.703297597508683 0.7731724737631867 0.3083588235187657 1.0 1.0 0.860988286733906 0.3274655233684744 0.2117897278125177 +Proteasome core complex 8 15 2.491461575464709 0.0127218726897477 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 1.0 1.0 6.641989928071465e-06 1.008572153882116e-06 1.580071287310929e-08 +Proteasome core complex beta subunit complex 5 7 2.432740871592172 0.0149850208054629 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 1.0 3.681542547339912e-07 7.924739528757158e-09 7.11341310276029e-07 +Translation preinitiation complex 7 15 2.3930427341225764 0.0167092947862934 5.929611650485437 14.939320388349516 -0.1339312390325661 0.6217842683135042 3.532429077701416 0.466038379468594 0.7741138416498823 0.2925161037128708 1.0 0.0516999782711156 0.1276511429081359 0.0574475369379932 5.772220110410818e-07 +Proton transporting v type atpase complex 1 9 2.345568521943613 0.0189980861622927 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 1.0 0.0488968448915506 0.0071140696266867 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b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7ea9ba92d4a835e790993d81d513dd6c931f926e --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 867, + "title": "Average number of proteins per term", + "value": 23.635524798154556 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5b44911de3f209b4a201e7cd7a8cc72cfc49a596 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2f7b938af1cfc1a3ce9b6b03ada1fec9236f8a61 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,287 @@ +Term es nes pval sidak 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0.0036356500824041 0.9574830529981762 0.1107379800630698 185 Q9C0C2,P04792,Q9NXV2,Q5VZE5,P30260,Q99460,P28072,P28074,Q9UL46,P28070,Q15257,Q6PD62,P54619,P30876,O00231,Q15014,P06730,Q99436,P61964,P49642,Q07864,Q9UBV8,P51665,Q6IAA8,Q6IA86,Q9H9Y6,Q9UJX2,P30153,Q9NT62,Q92499,P41227,Q9NXR7,P68036,P63151,Q9BUN8,O94880,O95163,O75340,P10644,Q86VP6,P49721,Q9Y4X5,Q3B726,Q9Y5K5,Q9GZZ1,Q9UNM6,P12956,P17612,P35998,P62191,P20618,O43242,Q9NR50,P49354,Q9BXJ9,Q9BVC5,Q16763,P48556,Q9UJX4,P25789,Q8TEY7,P25787,P54727,O43396,Q93034,Q5TBB1,Q92530,Q5BKZ1,Q15386,Q13200,Q92600,Q8NCA5,Q9HB71,Q9UBV2,Q9Y296,Q5VTR2,O95602,P63208,P09884,Q96S59,Q5VYK3,P60900,Q15008,Q5TAQ9,Q06323,Q14139 86 +Ubiquitin ligase complex 0.512550694565653 2.5111287362389025 0.012034580035602 0.999972388369868 0.1901700624484712 43 Q9NT62,Q16763,Q9NXR7,Q9UJX4,Q9BUN8,Q9NXV2,O75340,Q8TEY7,P30260,Q9Y4X5,Q9HB71,Q9UBV2,Q5VTR2,P63208,Q93034,Q96S59,Q9UJX2,Q5TAQ9,Q14139 19 +Proteasome core complex 0.7160323217858933 2.491461575464709 0.0127218726897477 0.999984897113372 0.1901700624484712 15 Q99436,P25787,P49721,P28072,P28074,P28070,P25789,P20618 8 +Proteasome core complex beta subunit complex 0.8713450676977229 2.4327408715921717 0.0149850208054629 0.9999979349153691 0.1968486823990358 7 Q99436,P49721,P28072,P28074,P28070 5 +Translation preinitiation complex 0.6972873188315203 2.3930427341225764 0.0167092947862934 0.9999995478977164 0.2130435085252416 15 P60228,Q7Z478,Q7L2H7,P55884,P56537,O75822,Q9Y262 7 +Proton transporting v type atpase complex 0.779765313149327 2.345568521943613 0.0189980861622927 0.9999999400534798 0.2244218149863217 9 Q15904 1 +Cytoplasmic stress granule 0.4844794128978827 2.2547535213063012 0.024148804150391 0.9999999993754316 0.2578402827651376 42 Q92499,Q8WWM7,O60828,P67809,Q14011,O95793,Q04637,O75534,P26196,Q6PKG0,Q9UN86,Q7Z417,Q14258,Q14974,P06730,Q8N543,P61978,P05198,Q6Y7W6,Q9Y5A9,Q9Y520,Q13148,Q13310,Q14157 24 +I band 0.5696591271710865 2.213308556709963 0.0268763800989062 0.9999999999448344 0.2741390770088437 24 Q8WX93,P04792,Q9Y281,Q9Y376,P30626,O00151,Q16637,P35609 8 +Cell cortex 0.4135930999740775 2.202252639977693 0.0276474675621654 0.9999999999722546 0.2787250508883419 74 Q13363,P15311,P09497,Q8TAG9,Q01518,P41440,Q14847,Q14203,P35241,Q14019,O00471,Q9NQW6,Q15691,Q02952,P17655,P61586,P35609,Q96J02 18 +Endoplasmic reticulum exit site 0.6822855227760439 2.1926055969919047 0.0283358075260988 0.9999999999849843 0.2823809784497439 13 Q15436,Q92734,Q5JRA6 3 +Eukaryotic translation initiation factor 3 complex 0.664826316748255 2.158471834187428 0.0308911659714568 0.9999999999984688 0.295689345757389 14 P60228,Q7L2H7,P55884,P56537,O75822 5 +Contractile fiber 0.472063329814284 2.1457114777421835 0.0318960048903735 0.9999999999993772 0.295689345757389 42 Q8WX93,Q9NYL9,P04792,Q9Y281,Q9Y376,P30626,P49257,Q05682,Q96HC4,P18206,Q9UJW0,Q14331,P60900,P0DP25,O00151,Q16637,P35609 17 +Apical junction complex 0.5684085308621941 2.128870725063614 0.0332649574434182 0.9999999999998174 0.3035865063520384 22 P61586,Q9NR77,Q9UDY2 3 +Actin cytoskeleton 0.3620424046195672 2.013591297767196 0.044052460835988 1.0 0.3637474623314439 106 Q9NYL9,Q9C0C2,Q9UQB8,Q14847,Q14019,P04083,O15143,O15144,Q92547,P35579,O75340,Q8WX93,Q99439,Q14247,Q01518,P35241,Q96HC4,Q9NQW6,Q9UJW0,Q13325,O00151,P35609,P15311,Q9Y281,P41440,P61978,Q05682,O14745,Q9Y5K6,P27695,P20339,Q15942,P17655,Q92747 34 +Microbody 0.4548651581421731 1.983063871437228 0.0473602955320342 1.0 0.3724811722768371 41 P48735,P34913,Q8N4Q0,O75874 4 +Adherens junction 0.4759159310506411 1.977139686123402 0.0480258429241766 1.0 0.3724811722768371 37 P35579,P15311,Q9NYL9,Q9C0C2,Q9UQB8,P41440,P31949,P35241,Q9BTW9,Q15942,P78344,P04083,Q9UDY2,Q9Y490,O00151 15 +Eukaryotic translation initiation factor 3 complex eif3m 0.7258215548731093 1.9525279029340217 0.050875561493543 1.0 0.3835574940426242 8 Q7L2H7,P56537 2 +Actin filament 0.5405939819470591 1.9462470948909576 0.0516250652727687 1.0 0.3858528585473322 22 P15311,Q8WX93,Q14247,Q14019,P04083,O00151,Q9Y5K6,P35609 8 +Triglyceride rich plasma lipoprotein particle 0.9914145543744892 1.895082334318336 0.0580814946557581 1.0 0.4094037062320515 2 P02656 1 +Protein lipid complex 0.9797024995989436 1.7733883986120185 0.0761643700579255 1.0 0.478510933624793 3 P02656 1 +Prefoldin complex 0.8424713584288027 1.7538337912704671 0.0794589910972649 1.0 0.4846111392265987 4 P61758,O15212,Q99471 3 +Exocyst 0.955437448896158 1.7507882350848805 0.0799823938884967 1.0 0.4846111392265987 2 Q8TAG9 1 +Cop9 signalosome 0.6507019697929896 1.7447813409220323 0.0810229379794365 1.0 0.4846111392265987 9 Q99627,Q9UNS2,P62993,Q9UBW8,Q92905,P61201 6 +Collagen containing extracellular matrix 0.5009769647789131 1.744637441732873 0.0810479990632719 1.0 0.4846111392265987 24 P02656,P51858,P04083,O60568,P35237 5 +N terminal protein acetyltransferase complex 0.8307922921891422 1.7080107185768607 0.087634353647783 1.0 0.5118082712346488 4 Q5VZE5,P41227 2 +Proteasome accessory complex 0.5043633034810269 1.6755778585856014 0.0938209087518078 1.0 0.5207879834035628 21 O00231,P35998,P48556,O43242,Q99460,P51665,Q9UL46,Q13200,Q15008,Q9UNM6,Q06323 11 +Nuclear ubiquitin ligase complex 0.6358062081133705 1.6731057768965154 0.0943064745032979 1.0 0.5207879834035628 9 Q16763,Q9NXR7,Q9UJX2 3 +Cullin ring ubiquitin ligase complex 0.4830851923403627 1.6538322456862198 0.0981616022212752 1.0 0.5342856192906614 25 O75340,P30260,P63208,Q16763,Q9HB71,Q9UJX4,Q9UJX2,Q5TAQ9,Q93034,Q9NXV2 10 +Early endosome membrane 0.4598583374560706 1.6224634445214132 0.1047041541404287 1.0 0.5603611212330355 30 Q9H4M9,Q99816,P20339,O60749,Q9Y5X3,P04083,Q9H223,Q9P258,Q15075,Q96J02 10 +Ciliary basal body 0.678324723292185 1.6051951677923275 0.1084508605754699 1.0 0.5612831879713596 7 Q15691,P28070 2 +Tight junction 0.5219422624064538 1.6048473381845492 0.1085274052668325 1.0 0.5612831879713596 18 Q9Y624,P16989,Q9UDY2,P11802,Q9NR77 5 +Podosome 0.6478630842577302 1.59533801374425 0.1106366692798146 1.0 0.5612831879713596 8 Q14247,Q8WX93,P18206,P61978 4 +Postsynaptic cytosol 0.7323795138864737 1.5739729315184734 0.115493707446787 1.0 0.5630365829283352 5 Q9UQB8 1 +Phagocytic cup 0.7922566618513069 1.5558260026831 0.1197494731215991 1.0 0.5672172009828447 4 P04083,Q9Y5X3 2 +Protein acetyltransferase complex 0.5355846320726398 1.5522640089610515 0.120599065905345 1.0 0.5672172009828447 16 Q5VZE5,P41227,P61964,Q15014 4 +Cul3 ring ubiquitin ligase complex 0.7271033818235559 1.551947156650625 0.1206748681989451 1.0 0.5672172009828447 5 Q9NXV2 1 +Vesicle tethering complex 0.6087843614572802 1.5420674291182808 0.1230572088356565 1.0 0.570393199146745 9 Q8TAG9,O00471,Q9Y296,P60953,Q96AX1,P83436 6 +Extrinsic component of plasma membrane 0.4622393564815572 1.5394934443879449 0.1236838770929504 1.0 0.570393199146745 26 P61586,Q15075,Q9Y5X3,P04083 4 +Cell cell junction 0.3492956695732044 1.50374544295651 0.1326469235428633 1.0 0.5885180457623644 85 Q9NYL9,Q9C0C2,Q9UQB8,Q9Y624,P78344,P04083,P61586,P35579,Q04917,Q99439,P62993,P31949,P35241,Q9UDY2,Q9NR77,O00151,P15311,P16989,P41440,Q9BTW9,Q9Y490,Q9Y5K6,Q15942,Q9NZW5,P11802 25 +9plus0 non motile cilium 0.7143077056575372 1.498414301572691 0.1340256429445587 1.0 0.5885180457623644 5 P35613 1 +Proton transporting two sector atpase complex 0.492338512599494 1.4919116146779288 0.1357223174269499 1.0 0.5885180457623644 19 Q15904 1 +Cilium 0.3664463857852135 1.4538375356569562 0.1459913541359112 1.0 0.6062820608078003 61 Q9NUQ9,A6NIH7,Q15555,Q9Y5Y2,Q92973,Q14203,Q9BW83,P04083,Q13526,P35613,Q15691,P28070,O14745 13 +Endoplasmic reticulum golgi intermediate compartment membrane 0.5069833481185534 1.4447571714131886 0.148526104927881 1.0 0.6082089213904326 17 Q15904,Q8N511 2 +Proteasome regulatory particle 0.4957721024452812 1.4419541938000329 0.1493152962301256 1.0 0.6082089213904326 18 O43242,P48556,P35998,Q99460,P51665,Q13200,Q15008,Q9UNM6,O00231 9 +Eukaryotic translation initiation factor 4f complex 0.6398250434330987 1.432591001935925 0.1519747547113827 1.0 0.6109433795302838 7 P23588,P06730,P78344,Q04637 4 +Excitatory synapse 0.8876849958107331 1.432095472088408 0.15211650013723 1.0 0.6109433795302838 3 Q9UQB8 1 +Microtubule plus end 0.6120477439218555 1.4279269265785293 0.1533128923814861 1.0 0.6109433795302838 8 Q15691,Q14203 2 +Ciliary transition zone 0.758883141603883 1.423048510406483 0.1547220930828856 1.0 0.6109433795302838 4 A6NIH7 1 +Calcium channel complex 0.6949514090401134 1.417162821024432 0.1564353290146747 1.0 0.6109433795302838 5 P0DP25,Q15257 2 +Cytoplasmic region 0.3818493865173039 1.365804129814908 0.1720004498226084 1.0 0.6422276862109203 47 Q13363,P09497,Q15555,Q9UQB8,P04792,P27695,Q99729,Q14203,O60828,Q99570,Q9Y2T2 11 +Sarcolemma 0.4573139271327215 1.3588212483746571 0.1742032384161094 1.0 0.6422276862109203 21 P41440,P04083 2 +Supramolecular polymer 0.3224916401871748 1.353096588567091 0.176024775367694 1.0 0.6422276862109203 163 O43633,Q9NYL9,P04792,Q9UQB8,Q14203,Q14019,P04083,P16949,Q9Y6G9,O14786,P08670,Q16637,P33176,P35579,Q8WX93,Q15555,Q14247,Q9Y376,P30626,Q96HC4,P56537,Q9UJW0,Q96TC7,O00151,P35609,O43237,Q02790,P52732,P15311,Q9Y281,P49257,Q05682,Q9BTW9,Q86TI2,Q9BUF5,Q9Y266,Q14331,P50570,P35580,Q9P258,Q9Y5K6,Q13409,Q15813,Q03252,Q15691,P60900,P0DP25,Q00535,P07197 49 +Set1c compass complex 0.6398520864489032 1.3424355733600668 0.1794548069156514 1.0 0.6422276862109203 6 O15047 1 +Scf ubiquitin ligase complex 0.6384736535381627 1.336394373409119 0.1814204044325409 1.0 0.6422276862109203 6 P63208,Q13617,Q9HB71,Q93034 4 +Gemini of coiled bodies 0.6755536614236056 1.3354886550706606 0.1817164659264523 1.0 0.6422276862109203 5 Q9UHI6,O75312,Q16637 3 +Retromer complex 0.6174693320644978 1.3316777741169077 0.182966095801055 1.0 0.6422276862109203 7 Q13596,O60749,Q9Y5X3 3 +Smn complex 0.6736342890431397 1.3273974797679982 0.1843772329429676 1.0 0.6422276862109203 5 Q9UHI6,Q9Y3F4,Q16637 3 +Cytosolic region 0.636373784440107 1.3271894733035343 0.1844460136868733 1.0 0.6422276862109203 6 Q9UQB8 1 +Photoreceptor outer segment 0.8558283900152095 1.3132735414757826 0.1890907907886165 1.0 0.6479909708052591 3 P35613 1 +External encapsulating structure 0.4254829592683689 1.3026112154188734 0.1927075268563323 1.0 0.6536030226049997 27 P02656,P51858,P04083,O60568,P35237 5 +Cyclin dependent protein kinase holoenzyme complex 0.5839133842362332 1.295486193190616 0.1951525612248139 1.0 0.6536030226049997 8 P14635,Q9P287,Q00535,P11802,Q9NYV4 5 +Transcription elongation factor complex 0.5065460754499546 1.2889905078032533 0.1974013865849757 1.0 0.6536030226049997 14 Q8WX92,Q08945,Q9H3P2,Q6PD62,Q9NYV4,O00267 6 +Actomyosin 0.4457290847598105 1.280174138183265 0.2004838992300917 1.0 0.6609108008839905 21 P35579,Q8WX93,Q9NVA2,Q99439,Q8WUM4,Q15942,P12814,Q96HC4,Q9UJW0,P35580,O00151 11 +Microtubule end 0.5527905077686364 1.2674648226221 0.2049891341522141 1.0 0.6656388738201109 9 Q15691,Q14203 2 +Extrinsic component of endosome membrane 0.8416962675447024 1.2605980603483655 0.2074536978418413 1.0 0.6681656943697045 3 P04083 1 +Ribonucleoprotein granule 0.3258951453091405 1.2588644896257632 0.208079281983645 1.0 0.6681656943697045 91 P51991,Q92499,Q8WWM7,Q99729,P67809,O60828,P62312,P19474,Q08J23,Q14011,O95793,Q04637,P25789,Q16637,O75534,Q92600,P26196,Q6PKG0,P25787,Q9Y2V2,Q9UN86,Q7Z417,Q14258,Q14974,P06730,Q8N543,P51116,P61978,P35998,Q7L2E3,Q92900,P05198,P60953,Q6Y7W6,Q92615,Q9Y5A9,Q9Y520,Q13148,P60900,Q13310,Q14157 41 +Membrane coat 0.3954770403399577 1.2333539822582755 0.2174437257838493 1.0 0.6804873862792806 35 O75340,Q9NVZ3,O43633,P42566,P09497,P35606,O95486,Q9UBF2,Q9Y678,Q15436,Q9UBV8,Q9Y2T2,P53680,P61923,P53621,O43747 16 +Cell cortex region 0.5309470813825602 1.2330435246631148 0.2175595259950751 1.0 0.6804873862792806 10 Q13363,Q14203 2 +Neuron projection cytoplasm 0.4187998286181232 1.2196050232825717 0.2226146412417398 1.0 0.6804873862792806 26 Q9UQB8,P04792,P27695,Q99729,O60828,Q9Y2T2 6 +Tertiary granule lumen 0.4988432641879663 1.2075552397877882 0.2272183849967035 1.0 0.6852837467456738 13 P36871,Q99439,O75874 3 +Site of polarized growth 0.3947333278906845 1.2007162711563508 0.229861280243917 1.0 0.6895838407317512 34 Q99720,Q8WX93,Q8TAG9,P51116,P27695,P80723,Q96A49,P0DP25,Q00535,O75312,Q02790 11 +Mediator complex 0.6426524764633654 1.1967000368193554 0.2314234926933123 1.0 0.6918764419486269 5 P11802,Q15648,Q9Y2W1,Q9ULK4 4 +Male germ cell nucleus 0.6051789657127605 1.1902913829093933 0.233931886471713 1.0 0.696972321549743 6 Q92547,Q15645 2 +Anaphase promoting complex 0.5839068625209688 1.1797349465884508 0.2381056500928706 1.0 0.7029284181089143 7 Q16763,Q9UJX2 2 +Cortical cytoskeleton 0.3915867778702205 1.174750405066577 0.2400945870738551 1.0 0.7056339220102793 34 P35579,P15311,Q01518,P41440,Q14847,Q05682,P35241,Q14019,Q9NQW6,Q15691,P17655,P35609 12 +Eukaryotic translation initiation factor 2b complex 0.5981862873349286 1.159602894013048 0.2462105221763864 1.0 0.71873576675733 6 Q9NR50,Q9UI10 2 +Trans golgi network membrane 0.4733737868433708 1.1409527864293934 0.2538895710131235 1.0 0.7243702363483855 15 Q9BXS5,P40616,P20645 3 +Alpha dna polymerase primase complex 0.6873977086743013 1.1375358359961718 0.2553143524994661 1.0 0.7243702363483855 4 P25205,P49642,P09884 3 +Clathrin coat 0.4641774064964972 1.1303076903650593 0.2583465951901456 1.0 0.7243954727289006 16 P42566,P09497,Q9NVZ3,Q9Y2T2,O43747 5 +Centrosome 0.2898468980896939 1.1196961736167792 0.2628432561711844 1.0 0.7302069889756013 116 P29966,Q15018,Q7Z6E9,Q14203,Q9P287,Q9Y6G9,Q3YEC7,P33176,Q8TEY7,P30260,O60271,P10644,Q92785,Q9H814,Q9BW83,Q15650,P28074,Q9UJW0,Q9Y696,O43237,P14635,P06493,Q9Y5Y2,P17612,P41440,P43487,P63208,Q9BTW9,O75935,Q9NTK5,P60953,P50570,Q86UY6,Q9Y5K6,Q5T4S7,Q6DKK2,Q13409,Q9Y5A9,P11413,P27695,O95684,Q9UN37,Q15691,Q5VYK3,P0DP25 45 +Protein phosphatase type 2a complex 0.6170185336059696 1.088715731113872 0.2762792624709511 1.0 0.7485441267572333 5 P63151,P30153,Q15257 3 +Endoplasmic reticulum golgi intermediate compartment 0.3692317671586183 1.0667729922066005 0.2860743571404764 1.0 0.7633238917031171 37 Q15904,Q8N511,P80303,Q9BVK6 4 +Neurofilament 0.7833197056418667 1.0558174314178437 0.2910516327642432 1.0 0.7707976162905723 2 P07197 1 +Early endosome 0.3167853636661125 1.0546070111520296 0.2916050958977021 1.0 0.7707976162905723 68 P02656,P41440,Q99816,Q9H4M9,P20339,O60749,P04083,Q9Y5X3,Q9H223,Q9UIQ6,Q96AX1,Q9BUN8,Q9P258,Q15075,Q96J02 15 +Supramolecular complex 0.2965893795437505 1.0429858423609033 0.2969548498429715 1.0 0.7720146839040404 277 Q8WWM7,P04792,Q99729,P67809,P04083,O14786,P19474,P08670,P33176,P35579,Q14247,Q6PKG0,Q96HC4,Q9UJW0,O43237,P06730,P14635,P49257,P60953,P35580,P00568,Q6Y7W6,Q15691,Q8NFH4,P18206,Q14157,P51991,O43633,Q92499,Q15018,Q9UQB8,Q16555,Q14019,P62312,Q14011,Q15149,O95793,O43264,O43683,O75534,Q16637,Q8WX93,Q9Y376,Q9UN86,Q96TC7,Q14974,Q02790,P06493,Q9Y281,P35998,P12814,O75935,Q86TI2,P68371,Q7Z460,Q8NI77,Q92598,Q92615,Q13409,Q9Y5A9,Q03252,P0DP25,Q14203,O60828,Q9Y6G9,Q04637,P25789,Q15555,P25787,P56537,P52732,Q8N543,Q9BUF5,Q9P258,Q9Y5K6,Q13148,Q15813,Q13310,Q00535,P07197,Q9NYL9,P16949,Q08J23,Q92600,P26196,P30626,Q9Y2V2,Q7Z417,O00151,Q14258,P35609,P15311,P51116,P61978,Q05682,Q9BTW9,Q7L2E3,Q92900,Q9Y266,Q14331,P05198,P50570,Q9Y520,P60900 104 +Postsynaptic density intracellular component 0.6628844087154657 1.040088818648 0.2982986379560017 1.0 0.7720146839040404 4 Q9UQB8 1 +Postsynaptic specialization intracellular component 0.6628844087154657 1.040088818648 0.2982986379560017 1.0 0.7720146839040404 4 Q9UQB8 1 +Distal axon 0.3493592738729443 1.027283695200115 0.3042868976620627 1.0 0.7765985829026719 43 Q99720,Q8WX93,Q8TAG9,P51116,P27695,P20339,Q05682,P80723,Q96A49,P0DP25,Q00535,O75312,Q02790 13 +Tubular endosome 0.6593835634456839 1.0262252159279015 0.3047854381482033 1.0 0.7765985829026719 4 Q9Y5X3 1 +P body 0.3882848411829918 1.0229321538867642 0.306339925435656 1.0 0.7765985829026719 27 Q9Y5A9,P26196,P25787,Q92900,P62312,P19474,Q9Y2V2,P25789,Q92600 9 +Cortical actin cytoskeleton 0.387776610886985 1.0191260417285235 0.3081431323539285 1.0 0.7770481422459303 27 P35579,Q01518,P41440,Q14847,Q05682,P35241,Q14019,Q9NQW6,P17655,P35609 10 +Neuron projection 0.2990754302572691 1.017861753626573 0.3087436597229471 1.0 0.7770481422459303 154 P04792,Q9UQB8,Q99729,P80723,Q14203,O60828,P78344,P16949,O14786,O15144,P98179,P61586,P08670,Q15075,Q16637,P33176,P25325,Q8WX93,Q8TAG9,Q15555,Q9Y296,Q9Y2T2,P35609,Q02790,Q99720,P18085,P51116,P55011,Q05682,P35613,Q9UBB4,Q96A49,P25685,O14745,P50570,Q6Y7W6,O75592,Q9Y5K6,O75251,P27695,P20339,P0DP25,Q00535,P17655,P07197,O75312 46 +Axon 0.3073604593613281 1.0168724882168745 0.3092140926427524 1.0 0.7770481422459303 91 P04792,P80723,Q14203,P61586,Q15075,Q16637,Q8WX93,Q8TAG9,Q02790,Q99720,P35613,Q96A49,O75592,Q9Y5K6,P27695,P20339,P0DP25,Q00535,P07197 19 +Microtubule organizing center 0.2971484469283702 1.0131290864220532 0.3109985067581751 1.0 0.7770481422459303 149 P29966,Q15018,Q7Z6E9,Q14203,Q9P287,Q9Y6G9,Q3YEC7,P08670,Q92547,O60763,P33176,Q8TEY7,P30260,Q15555,O60271,P10644,Q8WUM4,Q92785,Q9H814,Q9BW83,Q13526,Q15650,P28074,Q9UJW0,P28070,Q9Y696,O43237,P14635,P15311,P06493,Q9Y5Y2,P17612,P41440,Q9UNZ2,Q99816,P43487,P63208,Q9BTW9,O75935,Q9NTK5,P60953,P50570,Q86UY6,Q7Z460,Q5T4S7,Q6DKK2,Q9Y5K6,Q13409,Q9Y5A9,P11413,P27695,Q96CT7,O95684,Q9UN37,Q15691,Q5VYK3,P0DP25 57 +Motile cilium 0.3986643576842875 0.997730438391934 0.3184100891645314 1.0 0.7820440433587783 23 P04083 1 +Condensin complex 0.593123209169055 0.9885678906009489 0.3228746026708726 1.0 0.7866662847010725 5 Q9NTJ3,O95347,Q15021,Q9BPX3 4 +Chromatoid body 0.7653311529027013 0.9845833850289278 0.324828754236429 1.0 0.7866662847010725 2 Q08J23 1 +Mismatch repair complex 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.7936833007580535 2 P43246 1 +Nata complex 0.7639339879832967 0.97330851251583 0.3303999929510115 1.0 0.7936833007580535 3 P41227 1 +Immunological synapse 0.4656671685894682 0.9695864193500942 0.3322526849469129 1.0 0.7936833007580535 11 P35579,P15311,P51452,P10644,P52565,P17931 6 +Vesicle coat 0.3811367085402627 0.9694847429902284 0.3323033888987006 1.0 0.7936833007580535 27 O75340,Q9NVZ3,P09497,P35606,O95486,Q9UBF2,Q9Y678,Q15436,Q9UBV8,P53680,P61923,P53621,O43747 13 +Cytoplasmic ubiquitin ligase complex 0.5355179181286956 0.9614624432126212 0.3363197005105682 1.0 0.7965416113542769 7 Q9NT62,Q8TEY7,Q9BUN8 3 +Golgi transport complex 0.7555192150449757 0.9460401881072832 0.3441280887307372 1.0 0.8004003381591213 2 P83436 1 +Myosin filament 0.7547015535568308 0.9428394549579492 0.3457630272581382 1.0 0.8004003381591213 2 P35579 1 +Coated vesicle membrane 0.3384644097668771 0.9419975038448876 0.3461939178888933 1.0 0.8004003381591213 46 O75340,Q9NVZ3,P35606,Q8N511,P20645,Q15436 6 +Guanyl nucleotide exchange factor complex 0.7522485690924 0.9332481564387052 0.3506918559875736 1.0 0.808643189205389 2 Q9NR50 1 +Terminal bouton 0.545903536585949 0.9314005965433836 0.3516463824142715 1.0 0.8086934046503272 6 P20339 1 +H4 histone acetyltransferase complex 0.4679847953736195 0.9136176984083691 0.3609177633547391 1.0 0.819151049289421 10 Q15014 1 +Autophagosome 0.401345572109411 0.9044870920036544 0.3657371758271552 1.0 0.8279220142092523 19 O43633,P19474,Q9NRR5 3 +Ciliary membrane 0.5723268911176276 0.9021434309380232 0.366980680371983 1.0 0.828573567402368 5 Q9H4M9 1 +Non motile cilium 0.4990142530608784 0.8965995207593314 0.3699326538935072 1.0 0.8291118400262345 8 P35613 1 +Actin filament bundle 0.3819729690247969 0.8819962477180068 0.3777788364105299 1.0 0.8365675041155286 23 P35579,Q8WX93,P29966,Q9NVA2,Q99439,Q15942,P12814,Q96HC4,Q9UJW0,P35580,O00151 11 +Perinuclear region of cytoplasm 0.2865258366803209 0.8757975087753196 0.3811401246220576 1.0 0.8384294297630839 144 Q9UNS2,P20645,P55327,Q01105,O75340,Q8TEY7,Q8TAG9,O60271,Q9Y5X3,Q9NRR5,Q9UPY3,Q02790,P55145,P15311,P16989,Q9H4M9,O95831,Q9H223,Q96A49,Q9UBB4,Q9H3U1,Q9UIQ6,O14745,Q9UBF8,P50570,O75592,Q9Y5K6,O43747,Q99627,Q9H2J4,P27695,O95684,Q9UN37,Q8NC51,O75312,P17655,Q96AX1,Q15436,Q92530,Q99584 40 +Cell trailing edge 0.5316193285746456 0.8698396316731977 0.3843880498254264 1.0 0.8384294297630839 6 P35579,P15311,P41440 3 +Extrinsic component of membrane 0.3320799773331567 0.8673065961302066 0.3857740435284711 1.0 0.8384294297630839 43 P61586,Q15436,P04083 3 +Nuclear cyclin dependent protein kinase holoenzyme complex 0.7338511856091615 0.8618814715095726 0.388752745980115 1.0 0.8384294297630839 2 Q9NYV4 1 +Dna replication preinitiation complex 0.5120187468073485 0.856824461476347 0.3915419046945341 1.0 0.8402644340845571 7 Q9BRT9,P33993,P33991 3 +Clathrin vesicle coat 0.4413681774172998 0.8434364709692277 0.3989843818619865 1.0 0.8407595002249069 11 Q9NVZ3,P09497,O43747 3 +Ficolin 1 rich granule lumen 0.3059178938303805 0.837307086617605 0.4024199768946097 1.0 0.8407595002249069 63 P14174,Q99436,O75874,Q9Y376,Q14019,P09960,P51665,P20618,P36871 9 +Centriolar satellite 0.4194609263164869 0.8326973445294952 0.4050154425362615 1.0 0.8407595002249069 15 P11413,Q9Y5A9,P41440,Q86UY6,Q9Y5K6 5 +Elongator holoenzyme complex 0.7256745707277229 0.8305219657880558 0.406243733890383 1.0 0.8407595002249069 2 Q6IA86 1 +Polymeric cytoskeletal fiber 0.2776243368711485 0.8286749941511982 0.4072883392092974 1.0 0.8407595002249069 130 O43633,Q9UQB8,Q14203,Q14019,P04083,P16949,Q9Y6G9,O14786,P08670,P33176,Q8WX93,Q15555,Q14247,Q96HC4,P56537,Q96TC7,O00151,P35609,Q02790,P52732,P15311,Q9BTW9,Q86TI2,Q9BUF5,Q9Y266,P50570,Q9P258,Q9Y5K6,Q13409,Q15813,Q03252,Q15691,P0DP25,Q00535,P07197 35 +Proteasome core complex alpha subunit complex 0.5045153331071269 0.8237383082755078 0.4100882675955322 1.0 0.8424015140549299 7 P25787,P25789 2 +Protein kinase complex 0.3962231147688049 0.8204312783795876 0.4119702906104847 1.0 0.8424015140549299 18 P14635,P06493,Q9Y376,P10644,Q9NYV4,Q9P287,Q00535,P11802,P54619 9 +External side of plasma membrane 0.3946161543417553 0.8106290185142107 0.4175787471364645 1.0 0.847870664560456 18 P04083 1 +Cell substrate junction 0.2860975966247857 0.791313437378221 0.4287611090081227 1.0 0.8526052328211982 159 P04792,Q14847,P04083,P63173,O15143,O14786,O15144,P84098,P61586,P08670,P11233,P35579,Q8TEY7,Q8WX93,Q15555,Q99439,Q14247,Q01518,P35241,O00151,P35609,P05387,P15311,P41440,P61978,P07384,P35613,Q02952,Q9Y490,P50570,P17096,Q15942,Q15691,P46777,P17655,Q9UHB9 36 +Cell cell contact zone 0.3728020770125739 0.7766347879913591 0.4373742710060038 1.0 0.8574417125841929 20 Q9UDY2 1 +Proteasome regulatory particle lid subcomplex 0.4934653062425236 0.7753783521628956 0.438116123038982 1.0 0.8574417125841929 7 Q9UNM6,O43242,P48556,O00231 4 +Extrinsic component of cytoplasmic side of plasma membrane 0.4200326677521873 0.7347501656411172 0.4624916622602035 1.0 0.8716886891611978 11 P61586,Q9Y5X3 2 +Basolateral plasma membrane 0.3465095091009657 0.7332277096201462 0.463419557497557 1.0 0.8716886891611978 29 P41440,P04083 2 +Messenger ribonucleoprotein complex 0.5833321826991722 0.7314596024398212 0.464498471040915 1.0 0.8716886891611978 4 Q99729,P67809 2 +Specific granule membrane 0.4390164583467488 0.7149694327482434 0.4746279314592652 1.0 0.8828576009540713 9 Q9BXS5,Q5T4S7 2 +Dynactin complex 0.576867562668958 0.7072468387937149 0.4794130956630718 1.0 0.8828576009540713 4 O75935,Q9UJW0 2 +Histone pre mrna 3 end processing complex 0.6877470798267862 0.7029795207313422 0.4820685121443939 1.0 0.8834005994670491 3 P67809 1 +Arp2 3 protein complex 0.491758039379807 0.7015394601167843 0.4829664177017085 1.0 0.8834005994670491 6 O15143,O15144,Q92747 3 +Rpap3 r2tp prefoldin like complex 0.4898499849747714 0.6936535217954284 0.4878995201954565 1.0 0.8870077867622307 6 O15212,Q9H6T3 2 +Flemming body 0.40482080398858 0.6769972636690822 0.4984076905043542 1.0 0.8928088174943699 12 Q99816,Q9UN37,Q8TAG9 3 +Caspase complex 0.6827473426001691 0.6705104234062227 0.5025324640442146 1.0 0.8951235148873389 2 P17655 1 +Integrator complex 0.6769126706541867 0.6661595535880511 0.5053091223761528 1.0 0.8959161740288843 3 Q96SY0 1 +Aminoacyl trna synthetase multienzyme complex 0.4041854739433662 0.6558499821319095 0.5119206532945761 1.0 0.8984518348307642 11 P54136,P56192,Q13155,P41252,Q15046,Q9P2J5,P14868,Q12904,O43324,P07814 10 +Myelin sheath 0.42554129449403 0.652658548611433 0.5139764311156318 1.0 0.8985782709246596 9 Q9NR77 1 +Mrna editing complex 0.6728591834994149 0.652520365939147 0.5140655390756992 1.0 0.8985782709246596 3 Q96T37 1 +Presynaptic active zone 0.3980801776217122 0.6430863743446136 0.5201680553244443 1.0 0.9025329518273802 12 Q13363 1 +Sperm midpiece 0.5067013474208515 0.6381488424662516 0.5233767948052506 1.0 0.9043482092558164 5 Q9BW83 1 +Brisc complex 0.6642951928874409 0.6239650628697223 0.532650529647785 1.0 0.9091203347171116 3 Q9NXR7 1 +Dynein complex 0.4189355578351523 0.6225834255468384 0.5335583057345246 1.0 0.9091203347171116 9 Q14203,Q9Y6G9,Q13409,Q9UJW0 4 +Rnai effector complex 0.4676495311199955 0.6034075089183666 0.5462376281603776 1.0 0.9142625938514428 6 P26196,Q9UPY3 2 +Copi coated vesicle membrane 0.3921688259521093 0.5973651498799002 0.550263616001686 1.0 0.9143549644029624 11 Q8N511 1 +Germ cell nucleus 0.4322894910790784 0.5969250303525688 0.5505574349794711 1.0 0.9143549644029624 8 Q92547,Q15645 2 +Copii vesicle coat 0.4322844499776737 0.5969033956213832 0.5505718800801995 1.0 0.9143549644029624 8 Q15436 1 +Ruffle 0.3010214191338947 0.5937717573526374 0.552664781295584 1.0 0.9143549644029624 45 P35579,P15311,Q8WX93,P18085,P50570,P21281,Q9UQB8,P20339,P31949,Q9Y5X3,Q13325,P61586,O14745,Q9Y5K6,Q9Y490 15 +Mcrd mediated mrna stability complex 0.5454173486088356 0.5923403538231827 0.5536226987219783 1.0 0.9143549644029624 4 Q14103,O75534,P11940 3 +Anchoring junction 0.281870112666858 0.5900350147819466 0.5551671749152416 1.0 0.915075932797556 208 Q9NYL9,Q9C0C2,P04792,Q9UQB8,Q9Y624,Q14847,P78344,P04083,P63173,O15143,O14786,O15144,P84098,P61586,P08670,P11233,P35579,Q8TEY7,Q8WX93,Q15555,Q04917,Q99439,Q14247,Q01518,P62993,P31949,P35241,Q9UDY2,Q96HC4,Q9NR77,O00151,P35609,P05387,P15311,P16989,P41440,P61978,Q9BTW9,P07384,P35613,Q02952,Q9Y490,P50570,Q9Y5K6,P17096,Q15942,Q9NZW5,Q15691,P46777,P17655,P11802,Q9UHB9 52 +Cell division site 0.3413899322907583 0.5786644596088772 0.5628156013093524 1.0 0.9215119532593754 20 P35579,Q9NVA2,P35241,Q9NQW6,O75935,P35580,P61586,P11233 8 +Ccr4 not complex 0.646357040268426 0.5654009544543224 0.5718010755229974 1.0 0.9283736563266644 3 Q92600 1 +Keratin filament 0.6496320523303418 0.5539719896019616 0.5795980154978337 1.0 0.9327358099469916 2 P58107 1 +Nuclear inner membrane 0.3670061911937121 0.5482946927446947 0.5834895709873122 1.0 0.9333680037749073 15 Q99720,Q03252 2 +Coated vesicle 0.270980242825762 0.5447225451653969 0.5859443565663871 1.0 0.9347713338205828 67 O75340,Q9NVZ3,P35606,Q8N511,P20339,Q9BVK6,P20645,Q9BXS5,Q15436 9 +Derlin 1 retrotranslocation complex 0.5316641676795805 0.5438812537194953 0.5865231898482088 1.0 0.9347713338205828 4 Q9BUN8 1 +Costamere 0.4492219492219626 0.5309963558413093 0.5954213044508316 1.0 0.9389101203357492 6 Q09666,P51114,Q14315,P18206,Q15149 5 +Trans golgi network 0.3047085403377076 0.5291860317311508 0.5966764055267757 1.0 0.9389101203357492 37 P40616,P20645,O60568,Q9BXS5,P83436 5 +Vacuolar proton transporting v type atpase v0 domain 0.6347510856465302 0.5285037378466957 0.5971497534371171 1.0 0.9389101203357492 3 Q93050 1 +Proton transporting v type atpase v0 domain 0.6347510856465302 0.5285037378466957 0.5971497534371171 1.0 0.9389101203357492 3 Q93050 1 +Septin cytoskeleton 0.4771515070131565 0.5264732940312052 0.5985594026011962 1.0 0.9389101203357492 5 Q92599,Q9NVA2,Q9UHD8 3 +Neuron spine 0.3260487265916805 0.5231873474746375 0.6008438853808742 1.0 0.9389101203357492 24 P18085,Q9UQB8,P27695,P25685,P61586,Q15075,P35609 7 +Schaffer collateral ca1 synapse 0.3859948056362124 0.5201975827585468 0.6029258699450644 1.0 0.9389101203357492 10 Q02952,Q9UQB8 2 +Clathrin coated vesicle 0.307424821091098 0.5172450024881373 0.6049851407627296 1.0 0.9389101203357492 35 Q9NVZ3,P20339,Q9BVK6,P20645,Q9BXS5 5 +Trna splicing ligase complex 0.4436454833276386 0.5096110650398008 0.6103239703299546 1.0 0.9389101203357492 6 Q9BVC5,Q92499,Q8NCA5 3 +Neuronal ribonucleoprotein granule 0.6285045083081361 0.5089975806966746 0.6107539199040837 1.0 0.9389101203357492 3 O60828 1 +Dna repair complex 0.3630840872695871 0.5071699403437521 0.6120355845023495 1.0 0.9389101203357492 14 Q9BXW9,P43246,P54727 3 +Clathrin coated vesicle membrane 0.3272821098128474 0.4941210658050202 0.6212206813143906 1.0 0.9389101203357492 20 Q9NVZ3,P20645 2 +Er ubiquitin ligase complex 0.6232332634290008 0.4927397860646816 0.6221964616460847 1.0 0.9389101203357492 3 Q9BUN8 1 +Hrd1p ubiquitin ligase erad l complex 0.6232332634290008 0.4927397860646816 0.6221964616460847 1.0 0.9389101203357492 3 Q9BUN8 1 +Synaptic vesicle membrane 0.3685241296021469 0.4865977117015186 0.6265434455092607 1.0 0.9389101203357492 11 P20339,P0DP25 2 +Eukaryotic translation initiation factor 2 complex 0.6205722638505486 0.4846053902303563 0.6279562893974382 1.0 0.9389101203357492 3 P05198 1 +Signal recognition particle 0.4336285827668648 0.471886860472813 0.6370075472458341 1.0 0.9389101203357492 6 O76094 1 +Myosin ii complex 0.6159509202453908 0.4705977257489104 0.637928032020006 1.0 0.9389101203357492 3 P35579,P35580 2 +Brush border membrane 0.4321991221732496 0.4665797280426206 0.6408005934625363 1.0 0.9389101203357492 6 P41440 1 +Clathrin adaptor complex 0.400822455620482 0.4663023791832862 0.6409990760052757 1.0 0.9389101203357492 8 O43747,Q9Y2T2 2 +Ribose phosphate diphosphokinase complex 0.614314928425366 0.465675900456363 0.6414475050726134 1.0 0.9389101203357492 3 P11908,O60256 2 +Endoplasmic reticulum lumen 0.2839792477240496 0.461153591674052 0.6446884146389684 1.0 0.9389101203357492 49 P55145,Q9UNW1,O60568,Q02818,Q96AY3,Q5JRA6,O15460 7 +Ccr4 not core complex 0.6210139002453057 0.4596507365093174 0.6457669351867579 1.0 0.9389101203357492 2 Q92600 1 +Escrt complex 0.6119539166020278 0.4586076178024622 0.6465159652138897 1.0 0.9389101203357492 3 O43633 1 +Spindle microtubule 0.3153544695636153 0.4560490099565963 0.6483547357082113 1.0 0.9397801192910868 24 Q15691,O43633,Q96TC7,P0DP25 4 +Polysome 0.284707819411 0.4511213540785071 0.6519020879540258 1.0 0.9397801192910868 43 P51116,Q6PKG0,P20290,P63173,Q7Z417,P35580,P08670,P84098,P60900,P05198,Q04637,P61758,P83881 13 +Somatodendritic compartment 0.2563286858030428 0.4502436656868648 0.6525347541098434 1.0 0.9397801192910868 100 Q9UQB8,Q14203,P98179,P61586,Q16637,Q9H814,Q9Y296,P35609,Q02790,P18085,P51116,P55011,Q05682,Q9UBB4,Q96A49,Q02952,P25685,Q6Y7W6,Q9Y5K6,O75592,P27695,P20339,Q00535,P17655,O75312 25 +Photoreceptor inner segment 0.5002904486715686 0.4384617181257381 0.6610516150644297 1.0 0.9450403113648878 4 P35613 1 +Mcm complex 0.4218699757836487 0.4288364390737137 0.6680422586443124 1.0 0.9504225594059088 6 P33993,P33991 2 +Presynaptic endocytic zone 0.5995910020449997 0.4222895219311045 0.6728137052630174 1.0 0.9515978506737948 3 P09497,Q13492 2 +Perikaryon 0.3405311724991685 0.4168775956625687 0.6767679418070358 1.0 0.9556316051249186 15 Q96A49,Q00535,Q6Y7W6,O75592,Q16637 5 +Kinetochore microtubule 0.4148361815210784 0.4037780922220216 0.6863759079001066 1.0 0.9644860812794044 6 O43633,Q7Z460,O43264 3 +Proteasome regulatory particle base subcomplex 0.3640732756265633 0.3893815258528628 0.6969939360871249 1.0 0.9730978141506236 9 P35998,Q13200,Q99460 3 +Copi coated vesicle 0.3414714448802515 0.3783513543650232 0.7051696004704593 1.0 0.9766486319614828 12 Q8N511 1 +Golgi associated vesicle membrane 0.3263317749962791 0.3685349209005986 0.7124744114478625 1.0 0.9838691186779934 16 Q8N511,P09497,P35606,Q9UBF2,Q9Y678,P61923,O43747 7 +Cleavage furrow 0.3334917902917653 0.3682959089231819 0.712652602687174 1.0 0.9838691186779934 14 P35579,P61586,P35241,P11233 4 +Centriole 0.327212438535445 0.3553001966433141 0.7223647081609812 1.0 0.9938998201527688 15 O95684,Q14203,Q9Y5Y2 3 +Endosome 0.2496873373440204 0.3456123438314804 0.7296340679939668 1.0 0.9938998201527688 144 Q9UBF8,P02656,O43633,Q9BUN8,P41440,P20645,P04083,Q15904,P35613,Q9UIQ6,P61586,Q6Y7W6,Q15075,Q96J02 14 +Dendritic growth cone 0.5710246825854967 0.3432193001022143 0.7314334861939518 1.0 0.9938998201527688 3 Q7L576 1 +Dendrite terminus 0.5710246825854967 0.3432193001022143 0.7314334861939518 1.0 0.9938998201527688 3 Q7L576 1 +Golgi apparatus subcompartment 0.2642779863438994 0.3232910422551047 0.7464748373217265 1.0 1.0 54 P09497,Q9UNZ2,P40616,Q8NBZ7,Q8IWJ2,P20645,Q5VYK3,O60568,Q9Y296,P50570,Q9BXS5,P83436,O75592,O95372,O43747 15 +Ciliary tip 0.5614417437073269 0.3183511278959415 0.7502186055271749 1.0 1.0 3 Q9BW83 1 +Clathrin complex 0.5719542109566726 0.3155671404114561 0.7523310822416249 1.0 1.0 2 P09496 1 +Basal part of cell 0.2774297269932231 0.3147695646129861 0.7529366218368811 1.0 1.0 36 P41440,P04083 2 +Cytoplasmic side of membrane 0.2861528118846768 0.3135385428742686 0.7538715427970422 1.0 1.0 27 P35579,P15311,P11413,P20339,Q9Y5X3,Q9NR28,Q96A49,P61586 8 +Filamentous actin 0.3740616453544537 0.3070598576487731 0.7587978115807126 1.0 1.0 7 O00151,Q9Y5K6,Q96HC4 3 +Trans golgi network transport vesicle membrane 0.4115299801872965 0.3058591873220193 0.7597118614750098 1.0 1.0 5 P09497 1 +Nuclear replication fork 0.3157940147165841 0.2829448150779418 0.7772191401601525 1.0 1.0 13 P27694,Q9H4L7,P49642,O75717,P25205,P09884,P15927 7 +Cytoplasmic dynein complex 0.3658405744912015 0.2806416941729639 0.778985233303034 1.0 1.0 7 Q9Y6G9,Q13409,Q9UJW0 3 +Clathrin coat of coated pit 0.3224936199938021 0.2650854242050059 0.7909436555977656 1.0 1.0 10 P42566,P09497 2 +Intermediate filament 0.3019694810872702 0.2490199931380368 0.8033453161762538 1.0 1.0 15 P58107,Q03252,P56537,O14786,Q15149,P07197,P08670 7 +Pseudopodium 0.3203949580336455 0.2342314982457769 0.8148052630186395 1.0 1.0 9 P26038,P35609,P17655 3 +Ap type membrane coat adaptor complex 0.312694670785245 0.2320546531541077 0.8164955650617525 1.0 1.0 10 O43747,Q9Y2T2 2 +Cytoplasmic exosome rnase complex 0.3037755971391747 0.2267655160939544 0.8206060793660808 1.0 1.0 11 O00178,Q9Y2L1 2 +Cul4 ring e3 ubiquitin ligase complex 0.3579033579033537 0.2242513850351649 0.8225617019639664 1.0 1.0 6 Q9Y4B6,Q9NV06,Q92990,Q5TAQ9,Q16531 5 +Cell body 0.2397650675738604 0.2226501347130853 0.8238078138346414 1.0 1.0 74 Q9UQB8,Q14203,Q16637,Q8TEY7,Q9H814,Q02790,P51116,P55011,Q05682,Q9UBB4,Q96A49,P25685,Q02952,Q6Y7W6,O75592,P20339,Q00535,P17655,O75312 19 +Golgi membrane 0.2383635016819397 0.2168146226966923 0.8283528157493636 1.0 1.0 93 P35606,Q8TBQ9,P40616,Q15392,Q9BW83,Q9BVK6,P35613,O00400,Q8N6T3,Q9BXS5,Q9UBF8,Q15436 12 +Midbody 0.2382850753200917 0.2077697261431116 0.8354087718032079 1.0 1.0 65 O43633,Q15018,P61586,P11233,P50995,Q8TAG9,P31150,Q8WUM4,P35241,Q9NQW6,Q13526,Q9Y696,P06493,Q99816,Q9Y266,P60953,P50570,P35580,Q9P258,Q6DKK2,Q96CT7,Q9UN37,O00471,Q8N0X7 24 +Beta catenin destruction complex 0.4157119476268283 0.2030677528669977 0.839082076070663 1.0 1.0 4 Q9HB71,P48729,P49841 3 +Microvillus membrane 0.3685751306373434 0.1901431924210682 0.8491969247659608 1.0 1.0 5 P15311,O14745 2 +Side of membrane 0.2472400518443179 0.1852999340700324 0.8529937897385347 1.0 1.0 52 P11413,P41440,P20339,Q9Y5X3,P04083,Q9NR28,Q96A49,P61586 8 +Cell projection membrane 0.2489332945238342 0.1847653672586535 0.8534130730345129 1.0 1.0 45 P15311,P09497,P18085,P55011,P41440,Q9H4M9,Q15691,Q13325,P61586,O14745,Q9Y490 11 +Replisome 0.3030388262893648 0.1826399547837931 0.8550805322182797 1.0 1.0 9 P27694,P49642,P25205,P09884,P15927 5 +Zona pellucida receptor complex 0.3630781825624246 0.1773253393795882 0.85925284823238 1.0 1.0 5 P50990,P17987,P49368,P78371 4 +Cytoplasmic microtubule 0.2858659370526953 0.1767016708469268 0.8597427283830588 1.0 1.0 13 Q15691 1 +Rna cap binding complex 0.3520261972984047 0.1530103183309059 0.8783901382594059 1.0 1.0 5 O43148,Q7L576,Q06787,P06730 4 +Fascia adherens 0.3292383292383254 0.1527192430375095 0.8786196850288621 1.0 1.0 6 P14923,P19022,P12814,P18206,P35222 5 +Rna polymerase ii transcription regulator complex 0.2564818882630238 0.141390588933282 0.8875613885272366 1.0 1.0 21 P17096,Q9ULK4 2 +Intercalated disc 0.2702258726899377 0.1303685933445844 0.8962748133775031 1.0 1.0 13 P14923,Q04917,Q12955,P19022,P15924,P12814,P35221,P05026,Q6PI78,P18206,P35222,Q14126 12 +Multivesicular body 0.29432691209105 0.1265115759241488 0.8993269864076836 1.0 1.0 8 Q99816,O43633 2 +Transferase complex 0.2405340344380474 0.1263221228418326 0.8994769450357445 1.0 1.0 169 Q9NT62,Q96T37,Q16763,P41227,Q99570,Q9NXR7,Q9UJX4,Q99873,Q9BUN8,Q9H4L4,Q15075,Q9NXV2,O75340,Q8TEY7,Q5VZE5,P30260,Q9Y376,Q9Y4X5,P57081,Q9HB71,Q9UBV2,Q6PD62,P54619,P30876,Q5VTR2,O15047,O60256,Q15014,O95602,P14635,P61964,P63208,P49642,Q07864,Q8WWY3,Q9NYV4,P09884,A1L0T0,Q93034,Q69YN4,Q9NWX6,Q96S59,P49354,Q9UJX2,P17858,Q00535,O14744,P11802,Q5TAQ9,Q9BXJ9,Q14139 51 +Lipid droplet 0.2494557860228867 0.1223107682418074 0.9026529042063888 1.0 1.0 28 O60664,Q99720,Q9H4M9,Q9H6V9,Q15042,Q01105 6 +Nuclear lamina 0.3343163459392883 0.1181832706644775 0.9059224451302148 1.0 1.0 5 P56537 1 +Er to golgi transport vesicle membrane 0.2607324403939194 0.1163310503765385 0.907390178023229 1.0 1.0 16 Q15436 1 +Transcription repressor complex 0.2620561955984938 0.1112705161541068 0.911401834892262 1.0 1.0 14 Q13363 1 +Cul4a ring e3 ubiquitin ligase complex 0.4664758789861116 0.1031829799737147 0.917817747817923 1.0 1.0 2 Q92990 1 +Lamellipodium 0.2352178595281571 0.1008689864828772 0.9196544627110688 1.0 1.0 44 P61586,Q9UQB8,P41440 3 +Spectrin associated cytoskeleton 0.4486707566462266 0.1003703433752076 0.9200503134045072 1.0 1.0 3 P11171,Q01082 2 +Cuticular plate 0.4640228945216801 0.0999667729801393 0.9203707045901196 1.0 1.0 2 Q01082 1 +Nucleotide activated protein kinase complex 0.4456136144528375 0.0964997405490025 0.92312367997761 1.0 1.0 3 P54619 1 +Emc complex 0.3216837499249905 0.0964830058331008 0.9231369703343224 1.0 1.0 5 Q9NPA0 1 +Gamma tubulin complex 0.4441717791411086 0.094711092342481 0.924544307171744 1.0 1.0 3 Q9BSJ2,P38398 2 +Transport vesicle 0.2213485780819871 0.0943064342579557 0.9248657388983564 1.0 1.0 69 O75340,P35606,P20339,Q9BVK6,P20645,P0DP25,Q15436,O75592 8 +Sarcoplasm 0.2545265181678499 0.0922309663228866 0.9265145353249972 1.0 1.0 14 P28161 1 +Ciliary plasm 0.2553427614092765 0.0921623088828755 0.9265690837063704 1.0 1.0 11 Q15555,P17612,P27816,P10644,Q9UHD8,Q99570 6 +Organelle subcompartment 0.2455478871469641 0.0877085239608334 0.9301083445953352 1.0 1.0 263 P61009,P20645,Q15904,Q06136,Q9Y320,P61586,Q9BUN8,Q9BQE5,Q5JRA6,Q8NFQ8,O75340,Q8N511,P40616,Q15392,O00400,O60568,P38435,Q9NRR5,P56937,Q99720,P35606,Q9UNZ2,O75352,P35613,Q15042,Q9BXS5,Q9UBF8,P83436,Q96G23,Q9BVK6,Q04323,Q15436 32 +9plus2 motile cilium 0.2401471608468375 0.0851060816604262 0.9321770553857812 1.0 1.0 20 Q9BW83 1 +Transport vesicle membrane 0.2390244731976177 0.0797926769588957 0.936402148694394 1.0 1.0 33 O75340,P20339,Q15436,O75592 4 +Hemidesmosome 0.344926350245497 0.0781010780875832 0.9377476496259296 1.0 1.0 4 P58107,Q03001,Q15149 3 +Apicolateral plasma membrane 0.3449263502454966 0.0781010780875827 0.93774764962593 1.0 1.0 4 P19022,P58107,P35222 3 +Cd95 death inducing signaling complex 0.4411283728536468 0.0735305609713493 0.941383925752212 1.0 1.0 2 P49327 1 +Death inducing signaling complex 0.4411283728536468 0.0735305609713493 0.941383925752212 1.0 1.0 2 P49327 1 +Heterochromatin 0.2364168960067708 0.0695065297181902 0.9445864352624004 1.0 1.0 27 Q9H4L7 1 +Hippocampal mossy fiber to ca3 synapse 0.4171779141104326 0.0654601680449308 0.947807619579064 1.0 1.0 3 P47756,P63104 2 +T tubule 0.2802005303410693 0.0640348620510912 0.9489424678566928 1.0 1.0 6 P30626 1 +Nonhomologous end joining complex 0.4134969325153406 0.0620722319700892 0.9505053100219084 1.0 1.0 3 P12956,P13010 2 +Myosin complex 0.2703809913969656 0.0605378262133947 0.9517272901187144 1.0 1.0 7 P35579,O43795,P60660,Q9UM54,P35580,O00159 6 +Chaperone complex 0.2318780889621063 0.0601131058341236 0.9520655518944694 1.0 1.0 20 P48643,P50991,P40227,Q99832,Q8WXX5,Q9UNE7,P53041,P31948,P78371,P11142,P08238,Q9Y230,P50990,P49368,O95456,Q16543,P17987,Q969U7,Q15185 19 +Ubiquitin conjugating enzyme complex 0.3276260041875471 0.0582264772694041 0.9535682306845594 1.0 1.0 4 Q5VTR2,P61088 2 +Sperm annulus 0.4202780049059758 0.0547416463399283 0.9563442901053634 1.0 1.0 2 Q16181 1 +Microtubule 0.2181534671063512 0.0525438889923571 0.9580953252536816 1.0 1.0 96 O43633,Q9UQB8,Q14203,P16949,Q9Y6G9,Q15555,P56537,Q96TC7,Q02790,P52732,Q9BTW9,Q86TI2,Q9BUF5,Q9Y266,Q9P258,Q13409,Q15813,Q15691,P0DP25,Q00535 20 +Camp dependent protein kinase complex 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Ap 3 adaptor complex 0.4149632052330436 0.0506920735829095 0.9595708928947884 1.0 1.0 2 Q92572 1 +Nurd complex 0.2333118744780467 0.0425372035855459 0.9660704544051628 1.0 1.0 9 Q8WXI9 1 +U2af complex 0.3875421045216649 0.0419404338159709 0.966546183216145 1.0 1.0 3 Q15637 1 +Nuclear speck 0.2243994670496312 0.0394276410143495 0.9685494426958066 1.0 1.0 149 Q8WWM7,Q8WXF1,Q9BZZ5,Q15428,Q96T37,P80723,Q7Z6E9,Q7L014,O60828,O43660,P43490,P98175,Q8WXF0,Q66PJ3,Q13526,Q6PD62,Q9Y4C8,O15047,Q13247,Q8WWY3,Q9NTJ3,Q9C0B1,Q9H3U1,Q9NYV4,Q92766,Q69YN4,Q92733,P49750,P27695,Q6P6C2,Q9NVH1,Q9ULX6,Q8WXI9 33 +Transcription regulator complex 0.2170021625531716 0.034417640566588 0.9725441166671508 1.0 1.0 61 Q13363,Q9Y5Q8,P17096,P27695,P53999,P51858,Q8WXI9,P40763,Q12789,Q9ULK4,Q9BXJ9 11 +Paraspeckles 0.2493637176608921 0.0294915218262201 0.9764725806046576 1.0 1.0 6 Q8WXF1 1 +Endolysosome membrane 0.2412945514133536 0.0268761101608103 0.9785585479631916 1.0 1.0 7 O94973,P63010,Q96CW1,P09496,Q00610,P53680 6 +Mitotic cohesin complex 0.3708094848732699 0.0268573847744578 0.9785734832685676 1.0 1.0 2 O60216 1 +Microtubule minus end 0.351185609157817 0.0207853969569498 0.9834168467639728 1.0 1.0 2 Q15018 1 +Outer kinetochore 0.3427402862985607 0.0203633335012282 0.9837535334084452 1.0 1.0 3 P14635,O60566 2 +H3 histone acetyltransferase complex 0.3470973017170974 0.0197871839704626 0.9842131415933402 1.0 1.0 2 O94880 1 +Cohesin complex 0.2729132569558114 0.0187997709011402 0.9850008365857388 1.0 1.0 4 Q8N3U4,O60216,Q9UQE7 3 +Meiotic cohesin complex 0.2729132569558114 0.0187997709011402 0.9850008365857388 1.0 1.0 4 Q8N3U4,O60216,Q9UQE7 3 +Nuclear pore central transport channel 0.3274734260016433 0.0160381571887234 0.9872039505696806 1.0 1.0 2 Q7Z3B4 1 +Rna polymerase i complex 0.2269561655059374 0.0152796297885285 0.9878090936613592 1.0 1.0 7 O95602,O15446,Q9H9Y6,Q3B726,P19388,Q9GZS1 6 +Clathrin coat of endocytic vesicle 0.2410970118706523 0.0146994431184059 0.9882719636381724 1.0 1.0 5 O94973,P63010,Q96CW1,P53680 4 +Polysomal ribosome 0.2189645854909793 0.0125264011998374 0.9900056392513126 1.0 1.0 25 Q6PKG0,P20290,P63173,P84098,Q7Z417,P83881 6 +Exon exon junction complex 0.2553191489361726 0.012144273938744 0.9903105094958512 1.0 1.0 4 Q9BZI7,Q9Y5S9,Q92900 3 +Cell leading edge 0.2127615092043616 0.0106638737144828 0.9914916210647616 1.0 1.0 83 Q9UQB8,O60749,O15144,P61586,P08670,P35579,Q8WX93,P31949,P35241,Q9Y5X3,Q13325,P15311,P18085,P41440,Q86TI2,O14745,Q9Y490,P50570,Q9Y5K6,P21281,P20339,Q00535 22 +Nuclear outer membrane endoplasmic reticulum membrane network 0.240466310515568 0.009523828697461 0.992401198995476 1.0 1.0 225 P61009,Q15904,Q06136,Q9Y320,Q9BUN8,P61586,Q9BQE5,Q5JRA6,Q8NFQ8,O75340,Q8N511,Q15392,O00400,O60568,P38435,Q9NRR5,P56937,Q99720,P35606,O75352,P35613,Q9UBF8,Q96G23,Q9BVK6,Q04323,Q15436 26 +Vesicle membrane 0.2305548615981065 0.0039738970750372 0.996829297222825 1.0 1.0 176 O60664,Q9NVZ3,O43633,P20645,P04083,Q15904,O60749,Q9Y6G9,P61586,Q15075,O75340,Q8N511,P62993,Q9Y5X3,P35606,Q9H4M9,P35613,Q9H223,Q9UIQ6,Q9BXS5,P35237,O75592,Q99829,P20339,P0DP25,Q96AX1,Q15436,Q96J02 28 +Microvillus 0.2062074816629197 0.0002383116373087 0.9998098548257316 1.0 1.0 18 P21281,P35241,O14745 3 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..84150792570ece1b5592728c143fe7cc3dfcd553 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Chylomicron", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spherical high density lipoprotein particle", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATG3", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CAST", "CBFB", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP4", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GNA13", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT2", "GPATCH4", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSR", "GSTK1", "GSTM2", "GSTM3", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ISY1", "ITCH", "ITGB1", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC59", "LRWD1", "LSG1", "LSM2", "LSM6", "LSS", "LTA4H", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METTL13", "MFN1", "MGA", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NEK9", "NELFA", "NELFB", "NENF", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAK1IP1", "PAK2", "PALLD", "PARK7", "PARP1", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PECR", "PEF1", "PELP1", "PES1", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF5A", "PHF6", "PHF8", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIN1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPCDC", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2B", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAMM41", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF2", "TMA16", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TPD52", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM27", "TRIM28", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC37", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UCHL5", "UFD1", "UFL1", "UFSP2", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WTAP", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYND8", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABRAXAS2", "ACTN1", "ACTN2", "AHNAK", "AIFM1", "AIMP1", "AIMP2", "AK1", "AKAP12", "AKAP8L", "ALKBH5", "ANAPC5", "ANK3", "ANLN", "ANXA1", "ANXA11", "AP1G1", "AP1M1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "API5", "APOC3", "APOL2", "ARF4", "ARFGAP1", "ARHGDIA", "ARIH1", "ARL1", "ARL6IP4", "ARPC1A", "ARPC1B", "ARPC2", "ATG3", "ATP1B1", "ATP6AP1", "ATP6V0A1", "ATP6V1B2", "ATXN10", "ATXN2L", "BABAM2", "BAIAP2", "BASP1", "BCCIP", "BRCA1", "BSG", "BTF3", "BUB1", "BUB1B", "C2orf49", "CAB39", "CACYBP", "CALD1", "CALM3", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARHSP1", "CCDC124", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CERS2", "CFL2", "CHMP2A", "CIRBP", "CLASP1", "CLIC4", "CLTA", "CLTB", "CLTC", "CNN2", "CNOT9", "COG7", "COPA", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS5", "COPS7A", "COPS8", "COPZ1", "COTL1", "CPNE1", "CSDE1", "CSNK1A1", "CTBP1", "CTNNA1", "CTNNB1", "CTR9", "CTTN", "CUL2", "CUL5", "CYFIP1", "DARS", "DCAF1", "DCAF13", "DCAF8", "DCTN1", "DCTN3", "DCTN4", "DDB1", "DDX1", "DDX20", "DDX46", "DDX6", "DERL1", "DHCR24", "DHX29", "DHX30", "DIABLO", "DICER1", "DIS3", "DNAJB1", "DNAJC11", "DNAJC9", "DNM2", "DPF2", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DUSP3", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "EEA1", "EEF1E1", "EHD1", "EHD4", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3J", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF6", "ELP1", "ELP2", "EMC7", "EPB41", "EPHX2", "EPPK1", "EPRS", "EPS15", "EXOC5", "EXOC6", "EZR", "F11R", "FAM49B", "FAM98A", "FANCD2", "FASN", "FGFR1OP", "FKBP10", "FKBP4", "FLNC", "FMR1", "FNTA", "FRG1", "FTO", "FXR1", "FXR2", "G3BP2", "G6PD", "GATAD2B", "GCC2", "GDI1", "GGCX", "GIGYF2", "GINS4", "GLMN", "GRB2", "GSK3B", "GSTM2", "GTF3C1", "GTF3C5", "GTPBP1", "HDGF", "HMGA1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPK", "HSD17B7", "HSP90AB1", "HSPA8", "HSPB1", "HSPH1", "IARS", "IDH1", "IDH2", "IFIT5", "IFT27", "ILVBL", "INTS14", "ITCH", "JUP", "KARS", "KCTD5", "KDSR", "KIAA0368", "KIF11", "KIF18A", "KIF5B", "KPNB1", "LAMTOR1", "LARP1", "LARP4B", "LARS", "LASP1", "LDAH", "LGALS3", "LMAN1", "LMNB2", "LNPEP", "LSM6", "LTA4H", "LYPLA2", "M6PR", "MANF", "MAP4", "MAPRE1", "MAPRE2", "MARCKS", "MARS", "MCM3", "MCM4", "MCM7", "MED1", "MED23", "MIA3", "MIF", "MINPP1", "MORF4L2", "MPDU1", "MPP6", "MPST", "MSH2", "MSN", "MYCBP2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NAMPT", "NCAPD2", "NCAPG", "NDUFS7", "NECAP2", "NEFM", "NELFA", "NELFB", "NRP1", "NSFL1C", "NSUN2", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUFIP2", "NUP37", "NUP54", "OGFOD1", "OLA1", "P4HA2", "PABPC1", "PABPC4", "PALLD", "PDCD6", "PDCD6IP", "PDCL3", "PDLIM1", "PDLIM5", "PEF1", "PFDN5", "PFDN6", "PFKL", "PGM1", "PHAX", "PHF14", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PLEC", "PLIN3", "PLOD3", "PLRG1", "POLA1", "POLE", "POLR1A", "POLR1B", "POLR1E", "POLR2B", "POLR2E", "PPP2R1A", "PPP2R2A", "PPP5C", "PQBP1", "PRCC", "PRIM1", "PRKACA", "PRKAG1", "PRKAR1A", "PRMT1", "PRMT5", "PRPF31", "PRPS2", "PRPSAP2", "PRRC2C", "PSMA2", 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0000000000000000000000000000000000000000..f48ec4dda5572e8a8932802841dda91221b61e8f --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2679c3c0a752ea5b7193c968cebc7d9b6fa34f20d2089f9eb4d34c7c065e008f +size 149397 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..04568654022c1bbf739617cc97d283ef6f24406f --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,28 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Translation factor activity rna binding 21 52 3.110770451214068 0.0018659993312317 20.436893203883496 53.987864077669904 -0.3875060502954274 0.548917367166947 8.785104232007459 2.1344034206559086 1.1881193244272017 0.366265044062608 1.0 0.2060332174005789 0.0210183660887051 0.0069475041210434 7.073333044362515e-08 +Translation regulator activity nucleic acid binding 24 60 3.002646470954364 0.0026764314477902 20.885922330097088 62.970873786407765 -0.2153316283409681 0.5810585562874645 10.014266322329854 2.613283136412972 1.123797243693277 0.357239690044585 1.0 0.2406449336351452 0.0052847993880653 0.0040986150258472 3.66567605636962e-08 +Translation regulator activity 26 75 2.980215669167867 0.0028804550581575 25.199029126213592 78.43203883495146 -0.1449572932869035 0.5916688790638589 11.530424045500434 2.964636672584618 1.1118561159381193 0.3577333285619786 1.0 0.297212996865002 0.0124119304108533 0.0044081287311265 1.0307425179870492e-07 +Magnesium ion binding 7 58 2.9250938408456246 0.0034435236468259 21.71359223300971 72.79368932038835 -0.6147406093040623 0.4604947617504717 10.953144235755325 6.885940296543083 1.1504366681720746 0.3542485598642225 0.0176539819531368 0.0017981686843609 0.0470125964214753 0.0430757822148646 0.0198379320615783 +Translation initiation factor activity 16 34 2.869586811444547 0.0041100849176904 12.41504854368932 36.407766990291265 -0.0620726684038362 0.6020098880208691 6.262080887091644 1.941808251479095 1.008453552811725 0.334422762452143 1.0 0.1296041755358818 0.0489096908519388 0.0187855036977768 1.2618481056321197e-07 +Ubiquitin like protein transferase activity 26 45 2.5746085225596604 0.0100353599159228 20.140776699029125 63.69174757281554 -0.4203822608145132 0.5356722361377586 9.237407454698385 13.5494287435333 1.0516346378201498 0.3513436211625634 1.0 0.6186765974040395 0.9162878175872092 0.4028963842752502 0.421811459881465 +Threonine type peptidase activity 7 10 2.524523643156051 0.0115855211460038 3.8106796116504857 8.762135922330097 1.392634148189787 0.2146040118876429 1.6274593113109357 0.6695334565847216 1.0340073360925757 0.2572219198248905 1.0 1.0 2.8420326103882524e-06 2.5852675588111057e-07 4.6707016096661264e-08 +Threonine type endopeptidase activity 6 8 2.4909064492114563 0.012741766435405 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 1.0 6.100773603616506e-07 1.9452211361664793e-08 4.636449106765799e-08 +Nad binding 3 23 2.41018126820982 0.0159445963483304 8.563106796116505 29.28640776699029 -0.1611005483208177 0.4805202036040635 4.8695006879309135 2.252401029309141 1.131878946797942 0.3253122423834694 1.0 0.0002620337797657 0.0002967946504761 0.0138989947683802 0.0471865845485458 +Transferase activity transferring one carbon groups 21 52 2.3405968350103734 0.0192529449294001 15.330097087378642 60.89320388349515 -0.0477714165453824 0.6328340990686153 8.505438978887788 9.11113968909267 0.8654901708448212 0.3212092574275675 1.0 0.4213855951974318 0.0026130503804248 0.0022804235006738 0.0001178829140451 +Demethylase activity 3 8 2.3014965242387637 0.0213635816243105 2.1480582524271843 9.817961165048544 0.6057169859432091 0.4825187541655972 1.8354442113334128 1.8284079016462729 0.8653710828279827 0.3154015669224607 1.0 1.0 1.0 0.0067475693658363 0.0766534943106167 +Protein folding chaperone 5 24 2.27405242602008 0.0229628345965819 8.91504854368932 24.975728155339805 -0.3309401926740491 0.6382472915459364 5.225039299111076 1.2769020474264423 0.7349722495602489 0.2979961417581698 1.0 0.092800748795188 0.2216321691284184 0.0343943008431652 0.0036346316177125 +Pyrimidine nucleotide binding 0 5 2.264508546278122 0.0235428547191198 1.172330097087379 5.012135922330097 0.2915756451416036 0.3812019786090051 1.420006634664861 0.3375357600197503 1.227384965028187 0.3091745000997537 0.0005884660651103 0.0175288975408609 0.0444756670141454 0.1237601579731293 0.0283352150228686 +Signaling receptor binding 42 143 2.251836107843972 0.0243326309549529 37.12135922330097 173.84466019417476 0.0502519457009315 0.7989055459267156 13.136506240654874 17.387785737284005 0.6384544024115351 0.2942228802179928 1.0 0.2515637833224519 0.2889038070877047 0.0946674583717542 0.0011867852229755 +Cytokine activity 1 5 2.2362097308116327 0.0253380361072699 1.4368932038834952 5.75 0.9689346120623524 0.3423153019744804 1.105326054892273 0.6058973927039436 0.8855586242183912 0.2854448354224685 1.0 0.0683518202938552 0.0139536818673555 0.0952782699863604 0.3059455552422405 +Guanyl nucleotide exchange factor activity 11 23 2.1150655034217154 0.0344243648564537 6.533980582524272 32.932038834951456 0.2223318397638966 0.6556253667092978 4.677596955828533 6.172696120541664 0.7217460866024521 0.3041391835827391 1.0 1.0 1.0 0.2905918114299504 0.0809455404683001 +Endodeoxyribonuclease activity 3 11 2.1132933236742715 0.0345756698112929 2.8859223300970873 10.885922330097088 -0.0339232460428964 0.4846025979325279 2.2520962993487204 1.652916185502908 1.0066656755822607 0.2908047055763344 1.0 0.092800748795188 0.0255547766225395 0.160981864030255 0.0643145504824357 +Cis trans isomerase activity 6 20 2.093286787876385 0.0363235613512267 5.888349514563107 25.25728155339806 0.2561980004465105 0.5812219045702732 3.257874730761561 2.895731775037304 0.9309473322387666 0.3210818323454172 1.0 0.1061142727526517 0.0332133567806245 0.0001534741544288 0.0002845130862753 +S adenosylmethionine dependent methyltransferase activity 13 36 2.0901548726455683 0.0366038898154659 11.604368932038836 44.76699029126213 -0.0344811954285482 0.6338204342811783 6.857161258427814 7.630996936352693 0.8219252079821918 0.314473491654849 1.0 0.3379327385914417 0.0208041212790428 0.0109573800819302 0.0049996989443942 +Sh3 domain binding 7 8 2.060887258208451 0.0393137971683046 6.225728155339806 19.053398058252423 0.1092791230072861 0.6042540048985604 3.326857201432283 4.291792020177848 0.8356987682256717 0.3022221655556643 1.0 1.0 1.0 0.8633093780135226 0.4044705299631833 +Growth factor activity 2 5 2.04139278808432 0.0412118007272548 1.5048543689320388 5.609223300970874 0.2855357944033511 0.4112481245541766 1.5971685286433237 0.8786642436387735 1.1447785466231724 0.3004578148722612 1.0 1.0 1.0 0.0164525276609661 0.1068596312398967 +Nucleoside triphosphatase regulator activity 23 56 2.037640785164778 0.0415858700845257 17.00242718446602 76.74029126213593 0.0900034248583551 0.7173912664944249 10.002790578208364 11.746845389899176 0.7392790884701599 0.3088797993838402 1.0 1.0 0.9378638329081632 0.3841650337218441 0.1629294023157173 +Phosphatase regulator activity 10 17 1.9881835653608315 0.046791391919742 5.890776699029126 21.42718446601942 0.2207502835350587 0.5696921397829399 3.3115291951500065 3.3518635354302604 0.8778999195679603 0.2968997706719961 1.0 1.0 0.4518366860428483 0.5162548312130217 0.1585218843392109 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 3 6 1.984401446588876 0.0472111048996328 1.7839805825242718 5.402912621359223 0.124333058746836 0.3914974509468271 1.6038290588801534 0.6951924104236209 1.2069109191912994 0.2922321894579511 1.0 0.0347606010038453 0.0035377716455847 0.026979757634231 0.0016674553550596 +Lipoprotein particle receptor binding 0 9 1.9673341704706555 0.0491446981271521 3.79126213592233 9.766990291262136 -0.3051327745784666 0.5757747561792527 2.388305114434559 1.4511721642834725 0.8004886806424774 0.305710968477508 1.0 0.0572823062404515 0.1408010843614748 0.3564083857128934 0.6128233808005645 +2 oxoglutarate dependent dioxygenase activity 5 14 1.9658901832795972 0.0493112972755938 4.37378640776699 15.529126213592232 0.2154299112036777 0.6018350545707306 2.7299298033241417 2.7103946285223035 0.8539773022259993 0.3143886060204283 1.0 0.144931405556328 0.3315582327860309 0.0057421329596895 0.0347783194837162 +Molecular function regulator 80 223 1.9658448504084505 0.0493165351905102 62.91990291262136 291.44417475728153 -0.1413238113529792 0.758264160472997 26.642106464838285 29.856359847578553 0.769902774931518 0.3223250089449205 1.0 0.154870499787103 0.2005665274281348 0.0801471249014522 0.0198299220114886 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b6d3a357582d8c7eed5e9beddcd29bfeafb69793 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 1296, + "title": "Average number of proteins per term", + "value": 14.286265432098766 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9a6b46e252b464d1cc245773935674b013b5bf91 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fbf1fb3d3488e39f7a5e9eea6e87f8694229c3c7 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,364 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Translation factor activity rna binding 0.5600938271632088 3.110770451214068 0.0018659993312317 0.9111312085076178 0.1489285189467068 52 Q7Z2Z2,P60228,Q7L2H7,P78344,O75822,Q04637,P29692,P56537,P23588,Q9Y262,O00178,P55010,P06730,Q7Z478,P55884,P05198,P60842,P24534,P43897,Q9UI10,Q9NR50 21 +Translation regulator activity nucleic acid binding 0.5199514837576598 3.002646470954364 0.0026764314477902 0.9689856495599836 0.1489285189467068 60 Q7Z2Z2,P60228,Q7L2H7,P00374,P78344,O75822,Q04637,P29692,P34896,Q6PKG0,P56537,P23588,Q9Y262,O00178,P55010,P06730,Q7Z478,P55884,P05198,P24534,P60842,P43897,Q9UI10,Q9NR50 24 +Translation regulator activity 0.482366740537903 2.980215669167867 0.0028804550581575 0.9762092058133492 0.1489285189467068 75 Q7Z2Z2,P60228,Q7L2H7,P00374,P78344,O75822,Q14011,Q04637,P29692,P34896,Q6PKG0,P56537,P23588,Q9Y262,O00178,P55010,P06730,P51116,Q7Z478,P55884,P05198,P24534,P60842,P43897,Q9UI10,Q9NR50 26 +Magnesium ion binding 0.5192676580209595 2.9250938408456246 0.0034435236468259 0.9885585004474228 0.1489285189467068 58 Q9H773,Q9NWX6,P48735,P34913,O75874,Q969T7,P36871 7 +Translation initiation factor activity 0.6078773574120704 2.869586811444547 0.0041100849176904 0.9951928297487388 0.1489285189467068 34 P60228,Q7Z478,Q7L2H7,P55884,Q9UI10,P78344,P56537,Q9NR50,P23588,O75822,Q9Y262,P05198,P60842,Q04637,P55010,P06730 16 +Ubiquitin like protein transferase activity 0.5162826150595226 2.5746085225596604 0.0100353599159228 0.9999978956952644 0.1610106501757341 45 Q9NT62,Q7Z6E9,Q16763,Q9UPN9,Q15386,P19474,P68036,Q9ULT8,Q9Y3C8,Q9Y4X5,P61081,Q5VTR2,Q8TBC4,Q14258,Q9Y314,P60953,O75592,Q93034,Q5T4S7,Q7Z6Z7,Q96T88,Q12899,Q9UJX2,Q13263,Q96J02,Q14139 26 +Threonine type peptidase activity 0.7959088099227154 2.524523643156051 0.0115855211460038 0.999999723896607 0.1610106501757341 10 Q99436,Q9UJ14,P49721,P28072,P28074,P28070,P20618 7 +Threonine type endopeptidase activity 0.8488782851045498 2.4909064492114563 0.012741766435405 0.9999999394281808 0.1610106501757341 8 Q99436,P49721,P28072,P28074,P28070,P20618 6 +Nad binding 0.6060270283363066 2.4101812682098194 0.0159445963483304 0.9999999991018736 0.1714296505927423 23 P48735,P30837,O75874 3 +Transferase activity transferring one carbon groups 0.4751513764435996 2.3405968350103734 0.0192529449294001 0.999999999988574 0.1890289138522919 52 O75648,Q08J23,Q99873,Q7L2J0,Q9H7B4,Q6FI81,Q8IZ69,P34896,Q99707,Q86X55,P57081,Q8NCA5,Q14353,Q9BV44,O15047,P61964,Q9H9B1,Q05682,O60678,O14744,Q8N6R0 21 +Demethylase activity 0.8047190768052832 2.3014965242387633 0.0213635816243105 0.9999999999992996 0.2006318969935248 8 Q6P6C2,Q9C0B1,Q8NB78 3 +Protein folding chaperone 0.5787928648698595 2.27405242602008 0.0229628345965819 0.999999999999916 0.2133674106012542 24 Q9H2J4,P04792,O00273,P25685,P54652 5 +Signaling receptor binding 0.3739062580774154 2.251836107843972 0.0243326309549529 0.9999999999999865 0.2159937651891715 143 P02656,Q9Y624,O60749,P04083,P43490,Q9NXR7,Q9BUN8,Q9BQE5,Q92600,Q06124,Q8TEY7,P14174,O43768,P62993,P30626,P56537,Q9Y5X3,Q15257,Q14258,P35609,P55145,P41440,P51858,O14745,Q9Y490,Q9Y5K6,Q9NUQ9,Q9H2J4,O43776,P17096,P27695,Q9UMX5,P11047,P49354,P40763,P0DP25,P17931,Q00535,P28161,O75312,Q96J02,Q99584 42 +Cytokine activity 0.8955849977471387 2.2362097308116327 0.0253380361072699 0.9999999999999964 0.2210754152208256 5 P43490 1 +Guanyl nucleotide exchange factor activity 0.5607884499225383 2.1150655034217154 0.0344243648564537 1.0 0.2575291268703195 23 Q9NWX6,P18085,P29692,P80303,Q9UI10,Q9NR50,Q15042,Q02818,Q9Y2L1,Q9P258,O75592 11 +Endodeoxyribonuclease activity 0.6865307527627516 2.1132933236742715 0.0345756698112929 1.0 0.2575291268703195 11 Q9UPY3,Q9UQ84,P51530 3 +Cis trans isomerase activity 0.5729960740908273 2.0932867878763854 0.0363235613512267 1.0 0.265304622202706 20 Q9H2H8,Q13526,Q15257,Q96AY3,Q9Y3C6,Q02790 6 +S adenosylmethionine dependent methyltransferase activity 0.4947645538750318 2.0901548726455683 0.0366038898154659 1.0 0.265304622202706 36 P61964,Q9H9B1,O14744,O60678,P57081,O75648,Q08J23,Q99873,Q7L2J0,Q9H7B4,Q14353,Q9BV44,O15047 13 +Lipase inhibitor activity 0.9257325531305663 2.0756121860404897 0.0379298334660895 1.0 0.2674984228322589 4 P02656 1 +Sh3 domain binding 0.7500000000000023 2.060887258208451 0.0393137971683046 1.0 0.2674984228322589 8 P42566,Q96PU8,P62993,Q16204,P50570,Q9Y5K6,Q07666 7 +Growth factor activity 0.8464975626743961 2.04139278808432 0.0412118007272548 1.0 0.2674984228322589 5 P55145,Q9UMX5 2 +Nucleoside triphosphatase regulator activity 0.4342301052916341 2.037640785164778 0.0415858700845257 1.0 0.2674984228322589 56 Q8N6T3,O14786,Q9Y2L1,O60343,P29692,Q02818,Q8TC07,P55010,P18085,P43487,Q9BTW9,P52565,Q9H6Z4,Q15042,Q9H3U1,P24534,Q9P258,O75592,Q9NWX6,P80303,Q9UI10,Q9NR50,Q15436 23 +Phosphatase regulator activity 0.5981974800871649 1.9881835653608315 0.046791391919742 1.0 0.2866882236118067 17 Q5H9R7,O43768,Q9BTT0,P17931,Q86XL3,P0DP25,Q15257,Q9UQ13,Q01105,P30153 10 +Endodeoxyribonuclease activity producing 5 phosphomonoesters 0.7892627580670202 1.984401446588876 0.0472111048996328 1.0 0.2866882236118067 6 Q9UPY3,Q9UQ84,P51530 3 +2 oxoglutarate dependent dioxygenase activity 0.6287591783663217 1.9658901832795976 0.0493112972755938 1.0 0.2907079420357231 14 Q9Y2K7,Q6P6C2,O60568,Q9C0B1,O15460 5 +Molecular function regulator 0.3609552786594892 1.9658448504084505 0.0493165351905102 1.0 0.2907079420357231 223 P02656,P04792,P04083,P43490,O14786,O95373,P61586,P11233,Q8NFQ8,P14174,Q04917,Q99460,Q9BTT0,Q9UL46,Q15257,P61201,P54619,P55010,P14635,P31689,P41440,Q96KC8,Q86XL3,P60953,P35237,Q6IAA8,Q69YN2,Q9NWX6,Q9UMX5,P80303,Q15436,Q8N6T3,Q01105,Q9Y376,P40616,Q02818,Q8TC07,P61927,P55145,P51858,Q15042,P25685,O14745,O75592,P20339,O00273,O95684,O43242,Q9NR50,P49354,P0DP25,P23381,O60343,P29692,P20810,P52565,O14737,Q9H6Z4,Q9H3U1,Q9P258,Q9UI10,P17931,Q00535,P46777,P11802,Q92530,Q13200,Q9Y2L1,Q9UQ13,O43768,P30626,O60256,P18085,P43487,Q9BTW9,P24534,P04406,Q15008,Q15418,Q06323 80 +Enzyme inhibitor activity 0.4067608984905257 1.951459720281436 0.0510023832855641 1.0 0.2990908992673808 63 P02656,P04792,O00273,O95684,P20810,P04083,P17931,P46777,P61927,P35237,P23381,Q01105 12 +N methyltransferase activity 0.549153007301516 1.9412830061015385 0.0522239596477507 1.0 0.3048750076733555 20 Q9H9B1,P61964,O75648,Q99873,O14744,Q9H7B4,O60678,O15047 8 +Trna methyltransferase activity 0.8176532570721478 1.9250658775873657 0.0542211171664324 1.0 0.3137078921772161 5 O75648,Q9BV44,P57081 3 +Identical protein binding 0.2801351029757014 1.9095595069335756 0.0561899530126399 1.0 0.3146878361756759 386 Q9H773,P34913,Q92734,P04792,O75874,Q9UQB8,P04179,O60749,Q15637,P43490,P19474,O75822,Q99873,Q9Y320,Q9BUN8,Q92547,Q04637,Q15075,Q9NXV2,Q16637,P43246,Q13363,O75340,Q13630,P14174,Q9BZX2,P23381,P17812,Q15645,Q15631,Q15555,P34896,Q9UM22,O95563,Q9NRR5,Q15257,Q8IWA4,Q8TBC4,P53999,Q9NRF8,P51665,Q86TI2,Q16204,O14745,O75592,Q9NWX6,Q99829,P35637,O95684,Q03252,Q15691,P40763,Q01844,O14744,P28161,Q99584 56 +Cadherin binding 0.3587439327785099 1.9049000828300704 0.0567930604935886 1.0 0.3146878361756759 176 O60664,Q9NYL9,Q9C0C2,Q8WWM7,Q9UQB8,O75874,Q9Y624,Q14847,P60228,P00338,P78344,P04083,O60749,P33176,Q06124,P35579,P42566,Q99439,Q14247,P29692,Q6PKG0,P20810,P26196,P31949,Q9UDY2,Q9Y5X3,Q9NQW6,P35241,P28072,O00151,Q14258,P55010,O95372,P15311,P43487,Q9H4M9,P61978,Q05682,Q7Z478,P35613,Q9NTK5,Q9H223,Q9Y266,Q9H3U1,P25685,Q9Y490,P05198,Q6Y7W6,Q9Y5K6,Q8NC51,Q15691 51 +Cytokine receptor binding 0.5959712463338854 1.9018756345400376 0.0571874152681175 1.0 0.3146878361756759 16 P14174,Q9H2J4,P62993,Q9NXR7,Q9Y5K6,Q96J02 6 +Hydrolase activity acting on ether bonds 0.7689569920280621 1.8991323157191613 0.0575470811524962 1.0 0.3146878361756759 6 P34913 1 +Protein phosphatase regulator activity 0.5909512923292571 1.8731940760750176 0.0610415900644298 1.0 0.3231697463990033 16 Q5H9R7,O43768,P17931,Q86XL3,P0DP25,Q15257,Q9UQ13,Q01105,P30153 9 +Fad binding 0.7385375734978354 1.8708102268366589 0.061371389599391 1.0 0.3233224427675235 7 Q15392,Q8NB78 2 +Isocitrate dehydrogenase activity 0.8683526959294796 1.85481373616322 0.0636228298182564 1.0 0.3261539947663545 4 P48735 1 +Ubiquitin binding 0.5179494032843076 1.8273496722308995 0.0676472112041279 1.0 0.3303670855610207 23 Q8TEY7,Q9H4L7,Q9UNZ2,P04792,Q04323,P54727 6 +Epoxide hydrolase activity 0.7934713531896311 1.8265388756543028 0.0677691309751282 1.0 0.3303670855610207 5 P34913 1 +Ether hydrolase activity 0.7934713531896311 1.8265388756543028 0.0677691309751282 1.0 0.3303670855610207 5 P34913 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.5169056441355834 1.8202455261039163 0.0687216229223244 1.0 0.3303670855610207 23 Q9Y2K7,Q6P6C2,Q8NB78,O60568,Q9C0B1,O15460 6 +Dioxygenase activity 0.5816379976929942 1.8197856675043145 0.0687916512143007 1.0 0.3303670855610207 16 Q9Y2K7,Q6P6C2,O60568,Q9C0B1,O15460 5 +Oxidoreductase activity acting on ch oh group of donors 0.4276391164426107 1.8168728139231936 0.0692365902794935 1.0 0.3311093025912313 48 P48735,Q8N4Q0,Q06136,O75874 4 +Kinase inhibitor activity 0.6050500988815551 1.7870593221587194 0.0739279011286728 1.0 0.345313303946525 13 O95684,P04792 2 +Fk506 binding 0.7832243735465442 1.78452571134121 0.0743382807107102 1.0 0.345313303946525 5 Q96AY3,Q13451,Q02790 3 +Macrolide binding 0.7832243735465442 1.78452571134121 0.0743382807107102 1.0 0.345313303946525 5 Q96AY3,Q13451,Q02790 3 +Cell cell adhesion mediator activity 0.5838743190331548 1.7741333477070782 0.0760410959042594 1.0 0.3519616438997152 15 Q8WX93,Q9NYL9,Q9UQB8,P31949,P35613,P04083 6 +Oxidative rna demethylase activity 0.957890433360589 1.7606598695195967 0.0782959888529253 1.0 0.3570411571309346 2 Q9C0B1 1 +Proline rich region binding 0.8420053141459335 1.7520081871517597 0.07977240013687 1.0 0.3604770253730507 4 Q6Y7W6 1 +Ubiquitin like protein ligase activity 0.4712384017267466 1.7355922836434905 0.0826359513080012 1.0 0.3698716696781319 31 Q7Z6E9,Q15386,Q9Y4X5,Q9Y314,Q96T88,Q12899,P19474,O75592,P60953,Q5VTR2,Q9ULT8,Q96J02,Q14258,Q5T4S7,Q14139 15 +Signaling receptor regulator activity 0.5706239144370924 1.6993778018935313 0.0892480217428259 1.0 0.3817341128009982 15 P55145,P14174,Q9UMX5,P51858,P43490,P49354,P17931 7 +Tetrapyrrole binding 0.5963399167361351 1.6958119462675971 0.0899214993705916 1.0 0.3833495499483119 12 Q8WUJ1 1 +Protein arginine n methyltransferase activity 0.8256955810147263 1.6879669771323116 0.0914175682186106 1.0 0.3859191153463174 4 O60678,Q99873,O14744 3 +Cell adhesion mediator activity 0.5455114905182132 1.677012869484581 0.0935399652881385 1.0 0.3916774625934039 17 Q8WX93,Q9NYL9,Q9UQB8,P31949,P35613,P04083 6 +Gtpase binding 0.369461206761986 1.6749312315597489 0.0939477250343172 1.0 0.3916774625934039 71 Q8TEX9,Q92973,P67809,Q9P2R3,Q15904,O95373,Q8TEY7,P31150,Q8IWJ2,P55060,Q9Y2T2,Q14974,P43487,P16989,Q9H4M9,Q15042,Q9P258,O75592,O43747,Q6IAA8,Q9NUQ9,Q96S59,O00471,Q13177,O43592,O00410 26 +Endoribonuclease activity producing 5 phosphomonoesters 0.6176609199541185 1.6716419735415196 0.0945949427405365 1.0 0.3916774625934039 10 Q9UQ84 1 +Calcium dependent protein binding 0.5320398093246692 1.667263614628708 0.0954619982631568 1.0 0.3940087571625836 18 O75340,Q99816,P31949,P50995,P04083,P0DP25,Q99584 7 +Histone lysine n methyltransferase activity 0.5886755790001077 1.655317461755036 0.0978601186950411 1.0 0.3975759054193523 12 Q9H7B4,O15047 2 +Lysine n methyltransferase activity 0.5886755790001077 1.655317461755036 0.0978601186950411 1.0 0.3975759054193523 12 Q9H7B4,O15047 2 +Toxic substance binding 0.9300899427636978 1.6485428215656472 0.0992413310254671 1.0 0.3995799962193693 2 P34913 1 +Peptide alpha n acetyltransferase activity 0.8156450293409574 1.648362222783463 0.0992783632582074 1.0 0.3995799962193693 4 P41227,Q86UY6 2 +Trna guanine methyltransferase activity 0.8149413167191749 1.6455853959594204 0.0998491478879883 1.0 0.4006331135072227 4 Q9BV44,P57081 2 +Cell adhesion molecule binding 0.3442224705351053 1.6426927367442004 0.1004465223212127 1.0 0.401786089284851 194 O60664,Q9NYL9,Q9C0C2,Q8WWM7,Q9UQB8,O75874,Q9Y624,Q14847,P60228,Q9Y2I1,P00338,P78344,P04083,O60749,P33176,Q06124,P35579,P42566,Q8WX93,Q99439,Q14247,P29692,Q6PKG0,P20810,P26196,P31949,Q9UDY2,Q9Y5X3,Q9NQW6,P35241,P28072,O00151,Q14258,P35609,P55010,O95372,P15311,P43487,Q9H4M9,P61978,Q05682,Q7Z478,P35613,Q9NTK5,Q9H223,Q9Y266,Q9H3U1,P25685,Q9Y490,P05198,Q6Y7W6,Q9Y5K6,P11047,Q8NC51,Q15691 55 +K48 linked polyubiquitin modification dependent protein binding 0.7459151277056584 1.6303387929988211 0.1030299129631946 1.0 0.4057524605209862 5 Q9NRR5 1 +Protein demethylase activity 0.7425415087319953 1.616309754972369 0.1060273587859788 1.0 0.4077491305241202 5 Q8NB78 1 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.5755319687647393 1.5855878383429616 0.112832836835703 1.0 0.4250911527298578 12 Q9UPY3,Q9UQ84,P51530 3 +Nucleotidase activity 0.7347687614386573 1.5839373258577156 0.1132079822468599 1.0 0.4252682463534215 5 Q969T7,Q5TFE4,Q9H857 3 +Flap endonuclease activity 0.7987427881325717 1.5815371412350918 0.1137552736404807 1.0 0.4260891174510493 4 Q9UQ84 1 +Intramolecular transferase activity phosphotransferases 0.7962356792143961 1.571603094424101 0.1160426283849691 1.0 0.4307626398215901 4 Q96G03,O95394,P36871 3 +Epidermal growth factor receptor binding 0.7310683585755224 1.5685021195043904 0.1167639957083337 1.0 0.431128599538463 5 P62993,P18085,Q92600,O60749 4 +Modified amino acid transmembrane transporter activity 0.9059689288634524 1.5509233848301782 0.1209200455813332 1.0 0.4402033120039549 2 P41440 1 +Folic acid transmembrane transporter activity 0.9059689288634524 1.5509233848301782 0.1209200455813332 1.0 0.4402033120039549 2 P41440 1 +Cadherin binding involved in cell cell adhesion 0.5921142246868994 1.5434894083732853 0.1227120753833161 1.0 0.4442314237340161 10 Q9NYL9,Q9UQB8,P31949,P04083,O00151 5 +Ubiquitin like protein binding 0.4616350266219224 1.535071189402728 0.1247663423019744 1.0 0.447914624995454 26 Q8TEY7,Q9H4L7,Q9UNZ2,P04792,Q99816,Q04323,P54727 7 +G protein coupled glutamate receptor binding 0.900654129190515 1.5293847940194354 0.1261690798249655 1.0 0.4492173831130639 2 O14745 1 +Nucleoside kinase activity 0.7805006832647158 1.5091398533637856 0.131263046836739 1.0 0.4585361420496329 4 P55263 1 +Pentosyltransferase activity 0.5601669332386874 1.503658193121446 0.1326693990184237 1.0 0.4603282686901228 12 P43490,Q13126,P07741 3 +Amide transmembrane transporter activity 0.9063394683026532 1.5016139558679829 0.1331968370052438 1.0 0.4603282686901228 3 O00400,P41440 2 +Myosin binding 0.5966311754201161 1.4827589551841256 0.1381384647240739 1.0 0.4698883209511808 9 Q05682,P61586,P27695,O14745 4 +Protein arginine omega n monomethyltransferase activity 0.8871627146361412 1.4746814453466248 0.1402982067767824 1.0 0.4702859744387419 2 O60678 1 +L ascorbic acid binding 0.621334918595013 1.471491045732707 0.1411583673276779 1.0 0.4702859744387419 8 O60568,O75592,O15460 3 +Gdp dissociation inhibitor activity 0.707532929547825 1.4700099996567189 0.1415590457350175 1.0 0.4704115981348275 5 P43487,P52565,P55010 3 +Aminopeptidase activity 0.5512120191144366 1.4557279330299169 0.1454678448607693 1.0 0.4727627107824884 12 P55786,Q86TI2,P09960,Q9UIQ6 4 +Protein phosphorylated amino acid binding 0.5734656082119526 1.4492657529891697 0.1472633811887893 1.0 0.4747595572653507 10 P62993,Q13526,Q06124 3 +Gtp dependent protein binding 0.6996579797703442 1.4369459147023993 0.1507333621302136 1.0 0.4807794639882415 5 Q15075,O43747 2 +Ubiquitin like modifier activating enzyme activity 0.6612601058036002 1.436099658132927 0.1509739853744607 1.0 0.4807794639882415 6 Q8TBC4,A0AVT1 2 +Nedd8 transferase activity 0.8736713000817674 1.41996021887513 0.1556192627898753 1.0 0.4904996528281437 2 Q8TBC4 1 +Calcium ion binding 0.3467198063988477 1.4051620413127437 0.1599730987715184 1.0 0.4994131200161814 67 P04083,P55327,Q96AY3,O75340,P42566,P30626,P31949,Q9UM22,Q02818,P35609,Q9H4M9,P07384,Q9H223,O75592,Q99829,P80303,P0DP25,P17655,Q99584 19 +Adenylate cyclase binding 0.8801635991820056 1.404045013251715 0.1603054459311199 1.0 0.4994131200161814 3 P0DP25,Q02952 2 +Glutamate receptor binding 0.629167015041946 1.3845285090004311 0.166196684875286 1.0 0.5050353715779914 7 O14745,P41440 2 +Protein domain specific binding 0.319225502539655 1.3838751568188807 0.1663966849257734 1.0 0.5050353715779914 145 O43633,Q9C0C2,Q9UQB8,Q9Y624,Q96PU8,P80723,O76094,P20645,Q8WXF0,P61586,P08670,Q92600,P23381,Q13363,P35579,P42566,P62993,P40616,P26196,Q9UDY2,Q9HB71,Q6PD62,Q9UPY3,P54652,P35609,Q9Y3C6,P15311,Q9H9B1,P41440,P61978,P63208,Q16204,O14745,Q9Y490,P50570,Q9P258,Q9Y5K6,O00273,Q9UN37,P04406,P0DP25,Q07812,Q13263,Q9UHB9,Q07666 45 +Calmodulin binding 0.4312520503477396 1.3807267551825444 0.1673629915913648 1.0 0.5052579511815009 29 P35579,P29966,Q15417,Q99439,Q05682,Q13813,Q13576,Q01844,O60869,Q02952,Q9UII2,P35580,Q15075,Q5T4S7 14 +Kinase regulator activity 0.419727324375603 1.379692721346765 0.1676812749352598 1.0 0.5052579511815009 33 Q9Y376,O95684,P0DP25,P04792 4 +Protein methyltransferase activity 0.4508417979651745 1.363250933721594 0.1728034399444162 1.0 0.5069877110805765 23 Q9H9B1,P61964,Q86X55,Q8NCA5,Q99873,O14744,Q9H7B4,O60678,O15047 9 +Vascular endothelial growth factor receptor binding 0.8581357318070348 1.3569670656137218 0.1747916753844052 1.0 0.5069877110805765 2 Q9H2J4 1 +Transcription coregulator binding 0.4601742104917042 1.356740065970531 0.1748638170162173 1.0 0.5069877110805765 20 Q13363,P51858,P17096,Q9UQB8 4 +Translation elongation factor activity 0.5249479621701101 1.351395884654175 0.1765686513873086 1.0 0.509650272155795 13 P24534,P29692,O00178,P43897 4 +Kinesin binding 0.6772056729140279 1.3424516353529548 0.1794496020857436 1.0 0.5145280626175306 5 Q96EK5,O60271 2 +Organic cation transmembrane transporter activity 0.7350865193869268 1.328027076969217 0.1841691620268117 1.0 0.5245785362346111 4 O43772 1 +Translation initiation factor binding 0.477287234472363 1.3261601547694954 0.1847866542637424 1.0 0.5251831226443205 18 Q7L2H7,Q9UI10,P55884,Q04637,P55010 5 +Sulfur compound transmembrane transporter activity 0.6721781821967074 1.3212583429732878 0.1864152387167246 1.0 0.527416107171388 5 O00400 1 +Neurotransmitter receptor regulator activity 0.8479149632052343 1.315560145366403 0.1883217177333449 1.0 0.5291142982731869 2 P49354 1 +Enzyme regulator activity 0.3232566585820861 1.3154346036990876 0.1883638822778623 1.0 0.5291142982731869 179 P02656,P04792,P04083,Q8N6T3,O14786,Q13200,O95373,Q9Y2L1,Q9UQ13,P23381,Q01105,O43768,O60343,Q9Y376,P40616,P29692,P20810,Q99460,Q9BTT0,Q9UL46,Q02818,Q15257,P61201,P54619,Q8TC07,P61927,P55010,O60256,P14635,P18085,P43487,P41440,Q9BTW9,P52565,O14737,Q9H6Z4,Q86XL3,Q15042,Q9H3U1,P24534,Q9P258,P35237,O75592,Q6IAA8,Q69YN2,Q9NWX6,Q15418,O00273,O95684,P80303,O43242,Q9UI10,Q9NR50,P04406,P17931,P0DP25,P46777,Q15008,P11802,Q15436,Q06323,Q92530 62 +G protein alpha subunit binding 0.8560589014286507 1.3141331364553557 0.1888014046944073 1.0 0.5291142982731869 3 P80303 1 +Microtubule plus end binding 0.561968459941625 1.312658311637794 0.1892981110626104 1.0 0.5291142982731869 9 Q15691,Q14203 2 +Calcium dependent cysteine type endopeptidase activity 0.8470973017170894 1.312249445989112 0.1894359833323755 1.0 0.5291142982731869 2 P07384 1 +Calcium dependent phospholipid binding 0.5601968968024285 1.3039379838726015 0.1922547280511599 1.0 0.5312625320987278 9 P04083 1 +Beta catenin binding 0.513047562304653 1.2858608968566678 0.198491612727327 1.0 0.5415686949360334 13 Q86X55,Q13526,O14745,Q9Y5K6,O15047 5 +Polyubiquitin modification dependent protein binding 0.5054977016479192 1.2830782643501528 0.1994646579013497 1.0 0.5430802450423302 14 P42566,P46379,Q04323,Q9NXR7,Q9NRR5,P54727 6 +Metalloaminopeptidase activity 0.5545496519154671 1.2761298248730777 0.2019096301503959 1.0 0.5451800586046499 9 P55786,Q9UIQ6 2 +Transcription coregulator activity 0.2988240158378062 1.2585290582128534 0.2082004850494589 1.0 0.5495475124727064 116 P80723,O60828,Q15637,P19474,Q12824,Q99471,Q92600,Q13363,Q15645,Q9Y2K7,Q86X55,Q5VTR2,O00151,Q14258,Q9H1E3,P53999,Q99816,P51858,P25685,Q7Z4V5,P17096,P27695,P35637,Q96CT7,Q01844,O60869,Q9ULK4,O14744,Q92804 29 +Ribosome binding 0.3945170009779417 1.253975329689325 0.2098509725722241 1.0 0.5527781716536637 36 Q7Z2Z2,Q8IV48,P46379,P41227,Q8NC51,O76094,P56537,O60678,Q9NTK5,Q9Y3A5,Q8WWC4,P09132,P05198,Q9UHB9,Q9BXJ9,P08865,Q9BY44 17 +Cyclin dependent protein kinase activity 0.7115384615384546 1.233904660351252 0.2172384327446561 1.0 0.562469462727735 4 P11802,Q9NYV4,Q00535 3 +G protein coupled receptor binding 0.4357037665618611 1.2333743994690842 0.217436111748916 1.0 0.562469462727735 22 Q8TEY7,O43776,P31689,Q8WUM4,Q9Y5X3,P0DP25,Q96QK1,P50570,O14745,P11233,Q96J02 11 +Zinc ion binding 0.3086147112980436 1.2226283708808914 0.2214700924005401 1.0 0.5683668113883169 105 Q15428,Q7Z6E9,Q8N4Q0,Q15637,P19474,Q15075,Q8TEY7,Q86WB0,Q9Y2K7,P34896,Q99707,Q9Y4X5,O95602,Q9H9B1,Q05682,P09960,Q8NB78,Q92900,Q9UIQ6,P09884,O75592,P26639,Q99829,Q96T88,Q12899,Q8WXI9,O75312,P55786,Q15436,Q99584 30 +Protein arginine omega n asymmetric methyltransferase activity 0.8253578732106296 1.1997936761502523 0.2302194807922206 1.0 0.5801796400578411 3 O60678,Q99873 2 +Histone arginine n methyltransferase activity 0.8253578732106287 1.199793676150249 0.230219480792222 1.0 0.5801796400578411 3 Q99873,O14744 2 +Peptidyl proline dioxygenase activity 0.6427250815088187 1.197006294785607 0.2313041012334964 1.0 0.5801796400578411 5 Q8N543,O15460 2 +Titin binding 0.8184791496320545 1.1966445745518206 0.2314451187576409 1.0 0.5801796400578411 2 P0DP25 1 +Lim domain binding 0.8184791496320538 1.1966445745518184 0.2314451187576418 1.0 0.5801796400578411 2 Q9Y490 1 +Phosphatase activator activity 0.8211461668005451 1.1841433481993502 0.2363563232162875 1.0 0.588390808551521 3 Q15257 1 +Protein phosphatase activator activity 0.8211461668005451 1.1841433481993502 0.2363563232162875 1.0 0.588390808551521 3 Q15257 1 +Phosphatase inhibitor activity 0.6021304823380497 1.1769110743534723 0.2392310014383074 1.0 0.5914042132804721 6 P17931,O43768,Q01105 3 +Tropomyosin binding 0.8135731807031903 1.176897020048281 0.2392366116353781 1.0 0.5914042132804721 2 Q9NYL9 1 +Tau protein binding 0.4859547335849435 1.1728277012980557 0.2408649070808806 1.0 0.5923357107719569 14 Q13526,Q14203,P54652,Q02790 4 +Histone methyltransferase activity 0.4522528968036379 1.1689179423147442 0.2424366938349789 1.0 0.5939418137009834 18 P61964,Q99873,O14744,Q9H7B4,O15047 5 +Molecular function activator activity 0.5033464852818179 1.1677865584391496 0.2428928713437663 1.0 0.5939418137009834 11 Q96KC8,P31689,P25685,Q8NFQ8 4 +Atpase activator activity 0.5033464852818179 1.1677865584391496 0.2428928713437663 1.0 0.5939418137009834 11 Q96KC8,P31689,P25685,Q8NFQ8 4 +R smad binding 0.6922690994109204 1.1569598795825289 0.247288752337037 1.0 0.5971636650774677 4 Q9H6Z4 1 +Chemokine receptor binding 0.6919148749474004 1.15554696895852 0.2478665101735142 1.0 0.5971636650774677 4 Q96J02 1 +Nitric oxide synthase binding 0.807849550286184 1.1538923682364883 0.2485442984292549 1.0 0.5971636650774677 2 P0DP25 1 +Protein kinase a regulatory subunit binding 0.6320119864968088 1.15183497418855 0.2493888930883492 1.0 0.5971636650774677 5 P15311,Q9ULX6 2 +Protein membrane adaptor activity 0.5957112903421353 1.1487446432357284 0.2506612915139987 1.0 0.5971636650774677 6 O75340,O14745 2 +Iron ion binding 0.4741502076431058 1.145436031213155 0.2520285798251573 1.0 0.5989206646137413 15 O60568,Q9C0B1,O15460 3 +Histone methyltransferase activity h3 k4 specific 0.5870232356606915 1.1106516565050926 0.2667183186156547 1.0 0.6171871367845849 6 O15047 1 +Rna methyltransferase activity 0.4681003776979558 1.110517147676485 0.2667762430686844 1.0 0.6171871367845849 15 Q8IZ69,P57081,O75648,Q7L2J0,Q9BV44 5 +Ribosomal large subunit binding 0.5662113947064058 1.0996665798468623 0.2714774211460344 1.0 0.6197884444389367 7 Q9NTK5,P98179 2 +Copper ion binding 0.5394689864978524 1.0858321119354624 0.2775532765200488 1.0 0.6244948721701098 8 O60888,Q99584 2 +Signal sequence binding 0.4067445556783817 1.0769792894012489 0.2814895182582251 1.0 0.631103089577098 24 Q9UHB9,Q8TEX9,O60684,Q9NXR7 4 +Deoxyribonuclease activity 0.4455202659593052 1.0704799553604425 0.284403326739209 1.0 0.6333105007800942 17 Q9UQ84 1 +Phosphoprotein binding 0.4247491543204699 1.054777908722282 0.2915269103414664 1.0 0.640993185327617 19 Q06124,P62993,Q9Y2W1,Q13526,O95104,Q02790 6 +Cullin family protein binding 0.7846710318045304 1.0492496228717207 0.2940632452669554 1.0 0.6437600774763077 3 Q9NXV2 1 +Glucocorticoid receptor binding 0.7755519215045013 1.024974366575094 0.3053752828391876 1.0 0.6564354037755428 2 Q02790 1 +Alpha actinin binding 0.7725971370143168 1.0049498932032437 0.3149209779812132 1.0 0.6604168081936121 3 Q8WX93,O00151 2 +Actinin binding 0.7725971370143168 1.0049498932032437 0.3149209779812132 1.0 0.6604168081936121 3 Q8WX93,O00151 2 +Muscle alpha actinin binding 0.7725971370143168 1.0049498932032437 0.3149209779812132 1.0 0.6604168081936121 3 Q8WX93,O00151 2 +Rna cap binding 0.4841540020062422 0.9950826876943192 0.3196960499244126 1.0 0.6671917563639914 10 P60842,Q6PKG0,P06730,Q13325 4 +Dynein heavy chain binding 0.7660531697341414 0.9810365123726558 0.3265747363361331 1.0 0.6748155576743381 3 Q9Y6G9,Q13409 2 +Phosphatase activity 0.3676004150732435 0.9774187608210124 0.3283618788035121 1.0 0.6748155576743381 34 Q9NPH0,P34913,Q5TFE4,Q9UNW1,Q15257,Q9NQ88,Q969T7,Q06124 8 +Phospholipid transfer activity 0.7628781684382697 0.974925101886534 0.3295974135863087 1.0 0.6748155576743381 2 Q00169 1 +Phosphatidylcholine transfer activity 0.7628781684382697 0.974925101886534 0.3295974135863087 1.0 0.6748155576743381 2 Q00169 1 +Phosphatidylinositol transfer activity 0.7628781684382697 0.974925101886534 0.3295974135863087 1.0 0.6748155576743381 2 Q00169 1 +Peptide binding 0.3215155447571995 0.964909320634368 0.3345902325636738 1.0 0.678256113316256 61 Q8TEX9,Q9UHB9,Q92973,Q15392,Q9NXR7,Q9UIQ6,Q99471,P55786,P28161,P61758,Q9Y3C6,O60684 12 +Protein serine threonine kinase activator activity 0.5358415470096186 0.9629122938197768 0.3355915395122011 1.0 0.678256113316256 7 Q9Y376,P0DP25 2 +Gdp binding 0.4101476166205532 0.9607889162179892 0.3366583126889679 1.0 0.678256113316256 19 P20339,P61586 2 +Ubiquitin ligase substrate adaptor activity 0.759100204498979 0.9557124041656734 0.3392175539127122 1.0 0.6784351078254245 3 O75340,P63208 2 +Vitamin transmembrane transporter activity 0.6398593549268876 0.9492462370227442 0.3424953903635721 1.0 0.6818341411846229 4 P38435,P41440 2 +14 3 3 protein binding 0.7559280457890494 0.9476412259507684 0.3433121311867522 1.0 0.6824118435859369 2 Q9UBF8 1 +Nucleoside binding 0.6376262165526327 0.9404840786459364 0.3469693126180195 1.0 0.6864916466982114 4 P30876,Q9H9Y6 2 +Transcription elongation regulator activity 0.7534750613246148 0.9380417449760096 0.3482229574997029 1.0 0.6864916466982114 2 Q15061 1 +Transition metal ion binding 0.2893526178685077 0.9370489809561676 0.3487333632410643 1.0 0.6864916466982114 141 Q15428,Q8N4Q0,O60888,P04179,Q15637,P19474,Q15075,O15460,Q8TEY7,Q9Y2K7,P34896,Q99707,Q9Y4X5,O60568,P09960,Q8NB78,Q9C0B1,Q9UIQ6,O75592,Q99829,P55786,Q15436,Q969Z3,Q99584 24 +Phosphoserine residue binding 0.6360240378519497 0.9342037298437452 0.350198812116306 1.0 0.6864916466982114 4 Q13526 1 +Phosphotyrosine residue binding 0.5463440631734373 0.9333067167509164 0.3506616281745494 1.0 0.6864916466982114 6 Q06124 1 +Intramolecular transferase activity 0.5049094158621106 0.9239680688587572 0.3555029409571983 1.0 0.6904177507900451 8 Q96G03,O95394,P36871 3 +Gtpase activator activity 0.3699387425296727 0.9232247002850476 0.3558901193253305 1.0 0.6904177507900451 30 P43487,O60343,Q9BTW9,P52565,Q8N6T3,Q9H6Z4,Q15042,Q9H3U1,Q8TC07,Q15436 10 +Alpha tubulin binding 0.5764229325985561 0.9190952363918716 0.358045760669325 1.0 0.690516824147984 5 P49354,Q15813,Q92598 3 +Rna polymerase binding 0.386199174582615 0.9111747383064938 0.3622033120617995 1.0 0.6954303591586551 23 Q15061,Q92688,O95104,Q9H7B4,Q6PD62 5 +Kinase binding 0.2894887373869264 0.9045641421656176 0.3656963390933323 1.0 0.7000627111742374 147 P04792,Q7Z6E9,Q14203,Q9Y2I1,O14786,P19474,Q99873,P61586,P43246,Q92600,P23381,Q06124,P51452,Q86WB0,Q15555,O60271,Q9Y376,P62993,Q9UDY2,Q96HC4,Q13526,P56537,P54619,P14635,P52732,P15311,P55011,P50570,Q9NYV4,Q9P258,P13807,O75592,P09884,O95684,Q15691,P49354,P40763,P0DP25,Q00535,P17858,P18669,O75312,Q07666 43 +Chemoattractant activity 0.7428941133948044 0.8970683113808278 0.3696824667174934 1.0 0.7014765400671618 3 P14174 1 +G protein activity 0.4981157386280387 0.8924364767136337 0.3721590269435917 1.0 0.7051434194720685 8 P20339,P61586,P11233 3 +Rna polymerase core enzyme binding 0.4147072034847225 0.884471316252219 0.3764418398566229 1.0 0.706608485025939 17 Q9H7B4,Q15061,Q6PD62,O95104 4 +Nuclear import signal receptor activity 0.4443312573954746 0.8819021087315545 0.3778297466331293 1.0 0.706608485025939 12 Q8TEX9,O60684 2 +Protein kinase a binding 0.4345957578566133 0.8560119879765413 0.3919911485508967 1.0 0.719575819436207 13 P15311,P17612,P10644,P35241,Q9ULX6,P23396,Q02952 7 +Phosphatidylinositol 3 kinase binding 0.7307814784481469 0.8536397176056563 0.3933046447335608 1.0 0.7209657985497805 3 P0DP25 1 +Transferrin receptor binding 0.7301717089125148 0.8477401142335262 0.3965827208606312 1.0 0.724924127271337 2 O60749 1 +Catalytic activity acting on dna 0.2986339443808115 0.8434368489430334 0.3989841705489025 1.0 0.7281248088561081 69 Q9H4L7,P41440,Q9UQ84,Q9C0B1,Q9UPY3 5 +Transcription coactivator activity 0.2984799079828983 0.8399197901223908 0.4009533607214435 1.0 0.7281248088561081 70 Q9H1E3,P17096,P27695,P35637,Q99816,P53999,Q96CT7,O60828,Q86X55,P19474,O60869,Q12824,Q9ULK4,Q5VTR2,Q14258,O00151,Q92600 17 +Cargo adaptor activity 0.5060823577555209 0.8306326460109974 0.4061811865018565 1.0 0.7327851097284831 7 Q9BXS5,O43747 2 +Long chain fatty acid binding 0.7228127555192192 0.8196040967763939 0.412441837430697 1.0 0.7393148289214155 2 Q00169 1 +Amp binding 0.5028889622464341 0.8165919296582107 0.4141616686113702 1.0 0.7404444628063165 7 P06737,P17858,P07741 3 +Molybdopterin cofactor binding 0.7183618301021423 0.8095275054171961 0.4182117881998173 1.0 0.7414534576018649 3 Q969Z3 1 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.4245143667135576 0.8019822330324917 0.4225632357225284 1.0 0.7471240838968578 13 Q8N4Q0 1 +D1 dopamine receptor binding 0.717089125102212 0.7978638865101456 0.4249494823801134 1.0 0.7472653041582455 2 Q9Y5X3 1 +Protein macromolecule adaptor activity 0.2932244641237901 0.7870820696620022 0.4312338248973315 1.0 0.7532062494163635 67 O75340,P35579,Q02790,Q9UQB8,O60271,P62993,P63208,O43747,Q9UDY2,P40763,P59998,Q9BXS5,O14745,P53680,Q93034,Q07666,Q06124 17 +Clathrin binding 0.4100278746454935 0.7799297047151672 0.43543225281759 1.0 0.7564613936348481 15 P09497,Q10567,Q9H3U1,Q9BXS5,P53680,O43747 6 +Camp dependent protein kinase activity 0.710139002452989 0.771645518810811 0.4403244067535823 1.0 0.7613564911277823 2 P54619 1 +Cyclic nucleotide dependent protein kinase activity 0.710139002452989 0.771645518810811 0.4403244067535823 1.0 0.7613564911277823 2 P54619 1 +Oxidoreductase activity acting on ch or ch2 groups 0.7093213409648451 0.7685746077722679 0.4421458842909844 1.0 0.7613564911277823 2 P31350 1 +Endopeptidase activity 0.3184358499559381 0.7665163806484261 0.4433691089376346 1.0 0.7613564911277823 48 Q8TEY7,Q99436,Q99829,Q13867,P49721,Q86UV5,P07384,P28072,P28074,P60900,P28070,P17655,P25789,P20618,O43847 15 +Transcription corepressor binding 0.4260686661575697 0.7652467607242264 0.4441246198245396 1.0 0.7613564911277823 11 Q13363,P51858 2 +Translation activator activity 0.7028896241697518 0.7552537862123392 0.4500967217665939 1.0 0.7672329568354412 3 Q7Z478 1 +Nucleobase containing compound kinase activity 0.4191823466433946 0.7504064742099088 0.453009932872801 1.0 0.7688030101885583 12 Q9UDY2,P55263 2 +Dystroglycan binding 0.701431492842534 0.7501818476953795 0.4531451899265821 1.0 0.7688030101885583 3 P18206,Q15149 2 +Annealing activity 0.4462763003273092 0.7490085636030247 0.4538520439337596 1.0 0.7688030101885583 9 P46063 1 +Proteasome binding 0.445248267751946 0.7441703993296453 0.4567733933990663 1.0 0.7688030101885583 9 P46379,Q5VYK3,Q9Y5K5,P54727,Q92530,O95456 6 +Nedd8 specific protease activity 0.6970846495884888 0.7351088322239064 0.4622732157502449 1.0 0.7723686580680906 3 Q96FW1 1 +Signal recognition particle binding 0.5289836379272821 0.7258020970581097 0.4679601011707937 1.0 0.7778211246465578 5 Q9BUN8,O76094 2 +Cyclin dependent protein serine threonine kinase regulator activity 0.6899900660912099 0.7106651605633566 0.477291753847247 1.0 0.7879874050777479 3 P11802 1 +Rna polymerase ii specific dna binding transcription factor binding 0.28670927257091 0.7089484835027835 0.4783564465386185 1.0 0.7887404003995542 69 Q13363,Q99829,P17096,P04792,O15047,Q02790 6 +Signaling adaptor activity 0.4102651852399231 0.704652463812287 0.4810265407271417 1.0 0.7896508230630455 12 O60271,Q13112,P40763,Q9UN86,Q07666,Q06124 6 +Endoribonuclease activity 0.3832511834773991 0.699375303067289 0.4843175178811507 1.0 0.7915201805472527 17 Q9UQ84 1 +Ubiquitin protein transferase inhibitor activity 0.4719681621244634 0.6828321632845055 0.4947129033927435 1.0 0.7955174959525543 7 P61927 1 +Nucleotide transmembrane transporter activity 0.4203655915932164 0.6795542503848084 0.4967867460108834 1.0 0.7958413137578553 10 O00400,P41440 2 +Organophosphate ester transmembrane transporter activity 0.4203655915932164 0.6795542503848084 0.4967867460108834 1.0 0.7958413137578553 10 O00400,P41440 2 +Purine nucleotide transmembrane transporter activity 0.4304445110637511 0.6751904433735539 0.4995547775002271 1.0 0.7983020858696602 9 O00400 1 +Ubiquitin like protein conjugating enzyme activity 0.4694644216339236 0.6722089434039787 0.5014506882427865 1.0 0.8003449408407035 7 Q9Y3C8 1 +Channel regulator activity 0.4147598586858596 0.6528666478860294 0.5138422521613057 1.0 0.8153939079030363 10 P30626,O43768,O14745 3 +Phosphatase binding 0.3145920174759246 0.6515186275974018 0.5147117565035642 1.0 0.8153939079030363 39 O43768,P30260,P62993,Q9UJX4,Q9Y2V2,Q86XL3,P40763,Q15257,Q9UQ13,P17931,O14745,P15927 12 +Nuclear receptor coactivator activity 0.3811774281415038 0.6506326478194585 0.5152836501331688 1.0 0.8153939079030363 16 Q15648,P17096,Q99816,Q9Y2W1,Q86X55,P12814,Q92600,P35609 8 +Translation repressor activity 0.4422834611100782 0.6401942046701377 0.5220463500129677 1.0 0.8201445243620991 8 P34896 1 +Guanyl nucleotide binding 0.2774804673547503 0.6394822388547373 0.5225092643677245 1.0 0.8201445243620991 91 Q3YEC7,Q9NWX6,P41440,P20339,P40616,Q9H4M9,Q9BW83,Q9NTK5,Q9H223,Q9Y6G9,Q9BUF5,Q8IWA4,P61586,O00178,P55010,Q02790 16 +Keratin filament binding 0.6725265739983703 0.6338009248433916 0.5262107495573121 1.0 0.8236342166984015 2 P08670 1 +Intermediate filament binding 0.6725265739983703 0.6338009248433916 0.5262107495573121 1.0 0.8236342166984015 2 P08670 1 +Insulin like growth factor receptor binding 0.6713000817661546 0.6294376632029481 0.5290625672121918 1.0 0.8248455894537494 2 Q04917 1 +Four way junction dna binding 0.5005806384402529 0.614545553971678 0.5388548802304609 1.0 0.8305079272497079 5 P43246,O15347,P52701 3 +Molecular adaptor activity 0.2771780130768616 0.611061992241545 0.5411585406750383 1.0 0.832947112487945 86 Q9UQB8,Q04637,Q06124,P35579,O75340,Q13155,P62993,O60271,Q9UDY2,P59998,P53680,O95456,Q02790,P63208,P55884,Q9UBV8,O14745,Q9BXS5,Q93034,O43747,Q5VYK3,P40763,Q07666 23 +Phosphoric ester hydrolase activity 0.3027381015837744 0.6038005184946497 0.5459762747068422 1.0 0.8354543296984008 43 Q9NPH0,P34913,P27695,Q5TFE4,Q9UNW1,Q15257,Q9NQ88,Q969T7,Q06124 9 +Isopeptidase activity 0.4328679442016214 0.5994088867151013 0.5489002523248958 1.0 0.8354543296984008 8 P51665,O15372,Q9H4L4 3 +Co smad binding 0.662714636140644 0.5991602149771438 0.5490660505213034 1.0 0.8354543296984008 2 Q9UPN9 1 +Protein disaggregase activity 0.5470540098199574 0.5981865385410906 0.5497154725386721 1.0 0.8354543296984008 4 P46459,Q9UN37,P11142 3 +Protein tyrosine kinase binding 0.3586718169922881 0.5970563870825508 0.5504697345807683 1.0 0.8354543296984008 18 P56537,Q9UDY2,P49354,O75312,Q07666,Q06124 6 +Protein homodimerization activity 0.2631938317098206 0.5956835152161741 0.5513866728162591 1.0 0.8354543296984008 133 P34913,P04792,O75874,P34896,P51665,P19474,Q15257,P28161,Q15075,Q99584 10 +Carbohydrate derivative transmembrane transporter activity 0.4007857780892503 0.5874429870436291 0.5569062303961725 1.0 0.8363170514072537 10 O00400 1 +1 4 alpha oligoglucan phosphorylase activity 0.6531697341513246 0.5874334111958845 0.5569126599869716 1.0 0.8363170514072537 3 P06737,Q13126 2 +Prenyltransferase activity 0.6486707566462222 0.5728536413446157 0.5667437956418047 1.0 0.84425282661124 3 P49354,P14324 2 +Dna apurinic or apyrimidinic site endonuclease activity 0.6453987730061441 0.5623234869450682 0.5738956388539687 1.0 0.8519687834533143 3 P23396,P27695 2 +Hsp90 protein binding 0.368018589970757 0.5535217637985528 0.5799061819549094 1.0 0.8557208386656839 15 P31948,P55011,Q15185,Q00535,Q9H3U1,Q14974 6 +Transcription regulator activity 0.2623866814042858 0.5528228277597854 0.5803847354839013 1.0 0.8557208386656839 138 Q15061,P80723,O60828,Q15637,P19474,Q12824,Q99471,Q92600,Q13363,Q15645,Q9Y2K7,Q86X55,Q5VTR2,O00151,Q14258,Q9H1E3,P53999,Q99816,P51858,P25685,Q92766,Q7Z4V5,P17096,P27695,P35637,Q96CT7,P40763,Q01844,O60869,Q9ULK4,O14744,Q92804 32 +Dna secondary structure binding 0.3920577543630832 0.5474883219852871 0.58404329130219 1.0 0.8577333183106668 10 O15347,P17096 2 +Nucleocytoplasmic carrier activity 0.3484900827511762 0.5392046355220987 0.5897456621618575 1.0 0.85998360057259 18 Q8TEX9,Q92973,P55060,O00410,Q14974,O60684 6 +Insulin receptor binding 0.4506184425884476 0.5363924394830375 0.591687355537456 1.0 0.8606361535090269 6 O60749 1 +Atpase binding 0.3304908754912382 0.5289032028417257 0.5968726000485671 1.0 0.8648364423224877 22 Q9BUN8,Q04323,Q8NFQ8 3 +Nuclear localization sequence binding 0.3669779537612798 0.5264451872442688 0.59857892651487 1.0 0.8648364423224877 14 Q8TEX9,O60684 2 +Histone h3 di monomethyl lysine 9 demethylase activity 0.6406377759607591 0.5236232704070736 0.6005405929221967 1.0 0.8650236895691885 2 Q7LBC6 1 +7s rna binding 0.4332803502870881 0.5233784818359225 0.6007108955341587 1.0 0.8650236895691885 7 O76094 1 +Nucleobase containing compound transmembrane transporter activity 0.3713419325811161 0.5129190081928005 0.6080079764109227 1.0 0.8700843728797335 12 O00400,P41440 2 +Cyclin binding 0.3937937706038274 0.5115780488984351 0.6089463515862432 1.0 0.8700843728797335 9 P11802,Q9NYV4,P06493 3 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides 0.6224948875255598 0.4904776884144927 0.6237959142641687 1.0 0.8838943340253358 3 Q05682,Q16555 2 +Monocarboxylic acid transmembrane transporter activity 0.5138092189526494 0.4829345134177981 0.6291422349620448 1.0 0.8901401053611463 4 O95563 1 +Dopamine receptor binding 0.4647015719275432 0.4813628731504866 0.6302586187684402 1.0 0.890747186394655 5 O14745,Q9Y5X3,P50570 3 +Rna 7 methylguanosine cap binding 0.4347602831049387 0.4761023972739222 0.6340014292095388 1.0 0.8931150567995242 6 Q6PKG0,P06730 2 +Diphosphotransferase activity 0.614314928425366 0.465675900456363 0.6414475050726134 1.0 0.8942559373658917 3 P11908,O60256 2 +Ribose phosphate diphosphokinase activity 0.614314928425366 0.465675900456363 0.6414475050726134 1.0 0.8942559373658917 3 P11908,O60256 2 +Amyloid beta binding 0.3954516129973591 0.445018659371056 0.6563062696304649 1.0 0.8996532761003705 8 P61758,O15212,Q99471 3 +Cytoskeletal protein binding 0.2710392726243034 0.4442876459639274 0.6568346319273746 1.0 0.8996532761003705 195 Q9NYL9,Q14847,Q14203,Q14019,P16949,O15143,O15144,P61586,P61758,P11233,P33176,P35579,P51452,Q8WX93,Q15555,Q04917,Q99439,Q14247,Q01518,O60271,P35241,Q96HC4,Q9Y5X3,Q13526,Q9NQW6,Q96EK5,Q9HB71,P38435,P54652,Q96TC7,O00151,P35609,Q02790,P52732,P15311,Q9Y281,Q05682,Q9BTW9,O14737,Q14331,O14745,Q9Y490,P50570,Q9P258,O43747,P27695,Q15813,Q15691,P04406,P49354,P0DP25,Q00535,P17655,P07197,Q92747 55 +O methyltransferase activity 0.4243854230952091 0.4379273043863418 0.6614389817509188 1.0 0.9021025072253448 6 Q7L2J0 1 +Protease binding 0.3164974484221859 0.4373904529571132 0.6618282066715779 1.0 0.9021025072253448 21 P35237,P14174,P41440 3 +5s rrna binding 0.4237562713395459 0.435647307277877 0.6630926418474301 1.0 0.9021025072253448 6 Q9H7B2 1 +Dna helicase activity 0.3043652563351958 0.4352904551670059 0.6633516121803655 1.0 0.9021025072253448 29 P12956,Q9H4L7,P33991,P51530,Q92900,P33993,P46063,O14646,Q8IYB8 9 +Methyl cpg binding 0.3650345883990014 0.4292256457339154 0.6677590212805686 1.0 0.9059123906266596 10 O95983,Q99873,O14744 3 +Amidine lyase activity 0.6008179959100127 0.4258405267184258 0.6702240539301594 1.0 0.9059123906266596 3 P30566,O75592 2 +Clathrin heavy chain binding 0.5995910020449997 0.4222895219311045 0.6728137052630174 1.0 0.9059123906266596 3 P09497,Q13492 2 +Protein phosphatase binding 0.2968481182781298 0.4159198716218064 0.6774686379577599 1.0 0.9079178134228064 33 Q5H9R7,O43768,P30260,P62993,Q9UJX4,Q86XL3,P40763,P17931,Q15257,Q9UQ13,P15927 11 +Integrin binding 0.3360289232048127 0.41481750522805 0.6782755038283199 1.0 0.9079178134228064 16 P35579,P09429,Q9Y624,Q9Y2I1,P11047,Q9Y490,P35609 7 +Map kinase scaffold activity 0.596728016359925 0.4140510800716238 0.6788366984619594 1.0 0.9079178134228064 3 Q02750,O60271 2 +Growth factor receptor binding 0.3449063400980045 0.4053247834715038 0.685238791479222 1.0 0.9110496978043412 13 Q9H2J4,P62993,O60749,O14745,Q92600,Q9Y5K6 6 +Signaling receptor complex adaptor activity 0.4897493963326143 0.4048974478084864 0.6855528944716416 1.0 0.9110496978043412 4 O60271,Q06124 2 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters 0.6030253475061405 0.4040009263262769 0.6862120379960168 1.0 0.9110496978043412 2 P52758 1 +Ubiquitin like protein specific protease activity 0.3019485477033045 0.3852874379939271 0.7000244675387473 1.0 0.9182507185528506 25 Q8TEY7,Q9H8M7,Q96FW1,P45974,Q86UV5,Q92905,P51665,O15372,Q9H4L4 9 +Folic acid binding 0.5848812203320138 0.3806856938864463 0.703436485606699 1.0 0.920862308430588 3 P41440 1 +Basal transcription machinery binding 0.302274587035206 0.3774398557098184 0.705846752757997 1.0 0.9221546286031898 24 Q15061,O95104,O60869,Q9H7B4,Q6PD62 5 +Disordered domain specific binding 0.3271135037926582 0.372195712522554 0.7097471380743319 1.0 0.923526396530456 16 P54652,P15311,P0DP25,Q9Y3C6 4 +Dna binding transcription factor binding 0.2545989450324167 0.3680985106848305 0.7127997813520368 1.0 0.9256397962246892 89 Q13363,Q9H1E3,Q99829,P17096,P04792,O15047,Q02790 7 +Pdz domain binding 0.390988186349798 0.3645278304718095 0.7154638955834878 1.0 0.9281693780542544 7 Q9UQB8,O14745 2 +Protein phosphatase 2a binding 0.3900668900304636 0.3612993093123453 0.7178757099843427 1.0 0.9285669184044298 7 O43768,Q15257 2 +Ankyrin binding 0.574642126789367 0.3528320621205373 0.7242143455699381 1.0 0.9348163247748374 3 Q01082,Q15149 2 +Glucose binding 0.3983802785871278 0.3473897182167711 0.7282985566333606 1.0 0.9363838585286064 6 P13807,P11413 2 +Transcription factor binding 0.2388666840030049 0.3455179294278079 0.7297050335517707 1.0 0.9372470352365576 121 Q13363,Q9H1E3,Q99829,P17096,P04792,Q9UQB8,P51858,Q8NB78,P40763,O15047,Q02790 11 +Mrna 3 utr binding 0.269425803066416 0.3330504282904037 0.7390962176654468 1.0 0.9448929093048992 46 Q96EP5,P51116,Q92945,P16989,P35637,Q13148,Q8NC51,Q9Y2V2,Q13310,Q14011,P46777,Q5VTR2,Q92804 13 +Peptidase activity 0.2485001476253424 0.3278428903781457 0.743030456065001 1.0 0.9456120877315736 95 Q99436,P61009,Q99829,Q9H8M7,Q9UJ14,P49721,P09960,P51665,P81605,P28074,P28072,Q86TI2,P28070,Q9UIQ6,P55786,P25789,P20618,Q9HB40 18 +Endonuclease activity 0.2874559739571414 0.3272192043306007 0.7435020967580814 1.0 0.9456120877315736 29 Q9UQ84 1 +Alditol nadpplus 1 oxidoreductase activity 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.947293468743956 3 P14550,P15121 2 +D threo aldose 1 dehydrogenase activity 0.561963190184052 0.3196815776396701 0.7492097264371567 1.0 0.947293468743956 3 P14550,P15121 2 +Heat shock protein binding 0.2667974128801629 0.3107816179543248 0.7559666449295186 1.0 0.9530474434130896 42 P31948,O75937,P31689,P55011,Q13451,Q07812,Q9H3U1,P25685,Q00535,P54652,Q8WXX5,Q02790 12 +Transcription corepressor activity 0.2657032606239509 0.3034655327377866 0.7615351106433701 1.0 0.9550303880243584 41 Q13363,Q99816,P80723,P51858,Q15637,P25685,Q99471,O14744 8 +Cysteine type endopeptidase activity 0.3154700438320802 0.2916803023345797 0.7705310711032167 1.0 0.9574051916170953 14 Q8TEY7,Q13867,Q86UV5,P07384,P17655 5 +Misfolded protein binding 0.3362258140913369 0.2865608145141167 0.7744486220376077 1.0 0.957715089848034 9 P54652,Q9BUN8,P46379 3 +Nuclear export signal receptor activity 0.3787878787878792 0.2848062803897769 0.7757925603605453 1.0 0.9584624959268512 6 Q9UIA9,P62826,Q9HAV4,O14980,P55060 5 +C3hc4 type ring finger domain binding 0.5468302658486768 0.2821712378184728 0.7778122114752066 1.0 0.9600425010208264 3 P11142,P31689 2 +Vitamin d receptor binding 0.542522010569512 0.2719196910308433 0.7856837702652579 1.0 0.9637705086743192 3 Q9Y2W1 1 +Ubiquitin protein transferase regulator activity 0.3302662029728292 0.266299613122314 0.7900084710303488 1.0 0.9668092336688688 9 P61927 1 +Kinase activator activity 0.3192796341545559 0.2540326572016461 0.7994703286510172 1.0 0.970987436813216 10 Q9Y376,P14635,P0DP25 3 +Mutlalpha complex binding 0.5335826514081967 0.2512736857412764 0.8016025183703497 1.0 0.970987436813216 3 P43246 1 +Dna insertion or deletion binding 0.5335826514081967 0.2512736857412764 0.8016025183703497 1.0 0.970987436813216 3 P43246 1 +Mismatch repair complex binding 0.5335826514081967 0.2512736857412764 0.8016025183703497 1.0 0.970987436813216 3 P43246 1 +Mismatched dna binding 0.5335826514081967 0.2512736857412764 0.8016025183703497 1.0 0.970987436813216 3 P43246 1 +Protein kinase a catalytic subunit binding 0.3924529488292058 0.2511941459788535 0.801664010331899 1.0 0.970987436813216 5 P10644,P15311 2 +Sulfurtransferase activity 0.4323002322718862 0.2424885299477975 0.8084016434719938 1.0 0.9767950461364806 4 O75648,P25325 2 +Ephrin receptor binding 0.523879696879108 0.2298426485591862 0.8182140429934497 1.0 0.9791370265184772 3 P62993 1 +Structural constituent of cytoskeleton 0.2732489741150092 0.2256958446388932 0.8214379902053279 1.0 0.9811830740148432 25 P26038,O15143,O15144,Q16204,Q15149,P59998,Q9BUF5,P07197,P08670,Q9Y5K6,Q9Y490 11 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.3810463703994461 0.2209624346656782 0.8251216828141363 1.0 0.9846755993804058 5 Q9NYV4 1 +Unfolded protein binding 0.251437636019143 0.2188935347491238 0.8267329828730166 1.0 0.9856908425054548 53 Q7Z4Q2,Q8WXF0,Q99733,Q99471,P54652,P25685,P61758 7 +Mhc protein complex binding 0.3290797997097993 0.2154983903536927 0.8293787668963954 1.0 0.9876793536062566 8 Q9NUQ9 1 +Oxidoreductase activity acting on a sulfur group of donors 0.2736554144797747 0.2136095285191286 0.8308515682183639 1.0 0.9876793536062566 20 Q9UHG3 1 +Complement component c1q complex binding 0.5265739983646869 0.2065471964735592 0.8363635019811131 1.0 0.990792594668668 2 Q07021 1 +Ribonucleoprotein complex binding 0.2388138757168514 0.2051392132201039 0.8374633601340085 1.0 0.9909320437126246 84 Q9UHB9,P16989,P41227,O76094,O60828,P56537,P23588,Q9NTK5,P98179,O14744,Q9BUN8,Q9BXJ9,O60678,Q96J02 14 +Structural constituent of muscle 0.414830441522906 0.2010763854851998 0.8406388465309056 1.0 0.9909320437126246 4 P35609,Q15149 2 +Organic acid binding 0.2618843322737375 0.2003880392893036 0.8411771130472006 1.0 0.9909320437126246 34 Q8N543,P41440,P34896,P48506,O60568,Q00169,O75592,O15460 8 +Monosaccharide binding 0.2651581677204626 0.1996225964601926 0.8417757540484219 1.0 0.9909320437126246 29 P13674,Q8N543,P11413,P13807,P35613,P17858,O60568,P06737,O75592,O15460 10 +Amino acid binding 0.2895869499690209 0.1886911510726547 0.8503348874257683 1.0 0.9909320437126246 13 P34896,P48506 2 +Modification dependent protein binding 0.2484984387113499 0.1830743294082489 0.8547396975130703 1.0 0.9909320437126246 47 P42566,Q15018,P52701,P61964,P46379,Q92785,Q86X55,Q96T88,Q04323,Q9NXR7,Q9NRR5,P54727,O14646,Q7Z4V5 14 +Phosphoprotein phosphatase activity 0.2644477005353186 0.1741218592598408 0.86176969440161 1.0 0.9909320437126246 20 Q9UNW1,Q15257,Q06124 3 +Protein c terminus binding 0.2464689131552324 0.1693887013710955 0.8654909100897261 1.0 0.9909320437126246 43 Q13363,P15311,Q9UQB8,Q9Y520,O95104,Q15691,Q92547,P43246,Q9Y5K6 9 +Endopeptidase activator activity 0.3576770225267193 0.1651975261085387 0.8687885123936907 1.0 0.9909320437126246 5 Q16186,Q06323,Q9UL46 3 +S100 protein binding 0.3070661236900205 0.1562982071025176 0.8757979694971869 1.0 0.9909320437126246 8 Q9HB71,P15311,P31949 3 +Centromeric dna binding 0.4858888406131963 0.1561878807405601 0.8758849292675865 1.0 0.9909320437126246 3 P43246 1 +Peptidase activator activity involved in apoptotic process 0.499182338511867 0.1535172342049779 0.8779904004701431 1.0 0.9910656984172104 2 P63244 1 +Damaged dna binding 0.2568598190901188 0.1426826530550778 0.8865408173866396 1.0 0.9931823338454816 22 P09429,P27694,P52701,P27695,P39748,P54727,P43246,P15927 8 +Glutathione disulfide oxidoreductase activity 0.4918233851185721 0.1409659008344019 0.8878968804919989 1.0 0.993708425835605 2 P78417 1 +Ubiquitin specific protease binding 0.322744357731987 0.1384980358214045 0.8898468218449436 1.0 0.9941736906129716 6 Q9BUN8,P46379 2 +Proteasome activating activity 0.3218673218673202 0.1366350906390366 0.8913192382918949 1.0 0.9944417342820888 6 P62195,P35998,P62333,P62191,P17980 5 +Transferase activity transferring alkyl or aryl other than methyl groups 0.2682177141288954 0.1326622407095374 0.8944605063971718 1.0 0.995894172071078 15 P28161 1 +Nad retinol dehydrogenase activity 0.4832379394930611 0.1272284869579351 0.8987595592551387 1.0 0.9998217929567894 2 P14550 1 +Eukaryotic initiation factor 4e binding 0.3720924878282948 0.1176216147584354 0.9063674777297868 1.0 1.0 4 Q04637 1 +Protein deacetylase activity 0.4593047034764867 0.1146689709640842 0.908707509239462 1.0 1.0 3 Q92769,Q13547 2 +Receptor tyrosine kinase binding 0.2629462368847274 0.1136303992982833 0.9095307882647432 1.0 1.0 14 P49354,P56537,Q06124 3 +Mhc class ii protein complex binding 0.3006964358869291 0.111974730950879 0.9108434423250024 1.0 1.0 7 P14618,P07900,P11142,P08238,P62258,P50995 6 +Wd40 repeat domain binding 0.3608837970540071 0.1000524175194173 0.9203027110192972 1.0 1.0 4 Q16531,Q96K76,Q99459 3 +Arp2 3 complex binding 0.46402289452168 0.0999667729801393 0.9203707045901196 1.0 1.0 2 Q13576 1 +Camp dependent protein kinase regulator activity 0.4456136144528375 0.0964997405490025 0.92312367997761 1.0 1.0 3 P54619 1 +Membrane insertase activity 0.3216837499249905 0.0964830058331008 0.9231369703343224 1.0 1.0 5 Q9NPA0 1 +N6 methyladenosine containing rna binding 0.4410437156337686 0.0909113227426855 0.927563053204094 1.0 1.0 3 Q9Y5A9 1 +Protein carrier chaperone 0.2968938621837345 0.0893966870640406 0.9287666562713164 1.0 1.0 6 Q9NPA0 1 +Molecular carrier activity 0.2416530889865548 0.0873393684799355 0.9304017620438156 1.0 1.0 26 Q8TEX9,Q9NPA0,O60684 3 +Single stranded dna binding 0.2322168037364644 0.0846705731391203 0.93252329116585 1.0 1.0 49 Q9H1E3,Q15631,P53999,Q96AE4,P46063,P43246,P15927 7 +Adp binding 0.2470187538111065 0.0834000532771855 0.9335334461517408 1.0 1.0 17 P35579,P52701,P48506,P54619,P43246 5 +Actin binding 0.2231906487641029 0.0807042153844333 0.9356771843626804 1.0 1.0 90 Q9NYL9,P29966,Q14847,Q14019,O15143,O15144,Q15149,P35579,Q8WX93,Q04917,Q99439,Q14247,Q01518,P35241,Q96HC4,Q9NQW6,P38435,P59998,O00151,P35609,P15311,Q9Y281,P26038,Q05682,P12814,Q14331,Q9Y490,P35580,Q8NI77,P18206,Q92747 31 +Alpha catenin binding 0.3449263502454996 0.0781010780875863 0.9377476496259272 1.0 1.0 4 P19022,P18206,P35222 3 +Smad binding 0.2457402405447757 0.0716521579898543 0.9428787306367056 1.0 1.0 12 Q9UPN9,Q93008,Q9H6Z4,O95373 4 +Phosphatidylcholine transporter activity 0.4201668412841119 0.0683139347032958 0.945535731753874 1.0 1.0 3 Q00169 1 +Coa transferase activity 0.435404742436643 0.0678936034452416 0.9458703307165676 1.0 1.0 2 P55809 1 +Acyl coa oxidase activity 0.4354047424366389 0.0678936034452377 0.9458703307165706 1.0 1.0 2 Q15067 1 +Transcription coactivator binding 0.3359247135842862 0.0672640187757771 0.9463715208466336 1.0 1.0 4 Q00059,Q15648,P42224 3 +Pseudouridine synthase activity 0.4337694194603526 0.0663512846731511 0.9470981538824156 1.0 1.0 2 Q9Y606 1 +Ubiquitin like protein conjugating enzyme binding 0.2614961788820224 0.0653002229792601 0.9479349648132842 1.0 1.0 8 Q9UBT2,Q9Y4X5 2 +Dna polymerase binding 0.2457335209998372 0.0650994607946626 0.9480948097472146 1.0 1.0 10 Q9BXW9,P09429,Q9NVI1 3 +Oxidized dna binding 0.2976302334908086 0.0622884662342722 0.9503331132537458 1.0 1.0 5 P43246,P52701 2 +Microfilament motor activity 0.2703809913969655 0.0605378262133942 0.9517272901187148 1.0 1.0 7 P35579,O43795,P60660,Q9UM54,P35580,O00159 6 +Dna n glycosylase activity 0.3977900480374581 0.0491307028822737 0.9608151355831742 1.0 1.0 3 P27695 1 +Atp dependent activity acting on dna 0.2250849368485999 0.0480227637587364 0.9616981006783064 1.0 1.0 43 Q9H4L7,P41440,P51530,P46063,P43246 5 +Gamma catenin binding 0.3946830265848676 0.0468500619289891 0.9626327291607096 1.0 1.0 3 P35221,Q14574 2 +Transferase activity transferring sulphur containing groups 0.2443787408552556 0.0420432286261409 0.9664642371044329 1.0 1.0 8 O75648,Q7LGA3,Q2VPK5,P25325 4 +Adenylyltransferase activity 0.3081014729950908 0.0403771774178205 0.9677924251904192 1.0 1.0 4 O43252,Q9NQX3,Q15046 3 +Histone h3 methyl lysine 9 demethylase activity 0.3832310838445818 0.0391933351259958 0.9687362473544554 1.0 1.0 3 Q9UPP1,Q7LBC6 2 +Double stranded telomeric dna binding 0.2561854720505992 0.0358419091596371 0.9714084158433156 1.0 1.0 6 P12956,P27695 2 +Phospholipid transporter activity 0.2933031675240728 0.0297855130745281 0.9762381125333526 1.0 1.0 4 Q00169 1 +Udp glucosyltransferase activity 0.2648383135489164 0.0296822500266754 0.9763204681114152 1.0 1.0 5 Q9NYU2,P13807,Q9Y673,Q6UW63 4 +Uridylyltransferase activity 0.3753066230580604 0.0285855598937973 0.977195128914601 1.0 1.0 2 Q16222 1 +G rich strand telomeric dna binding 0.244501882509276 0.0253801741490097 0.9797517247513684 1.0 1.0 6 P22626,P15927 2 +G quadruplex rna binding 0.3638593622240467 0.0244462518415553 0.9804966557010676 1.0 1.0 2 Q9H2U1 1 +Poly pyrimidine tract binding 0.2157296397050427 0.0215805229032247 0.9827825703857638 1.0 1.0 13 Q13310,Q07666,Q13325 3 +Protein phosphatase 1 binding 0.2703897545620669 0.0176980923009689 0.9858797025336514 1.0 1.0 4 Q9UQ13 1 +Kinetochore binding 0.334832379394938 0.0172583819444802 0.9862304870510352 1.0 1.0 2 Q7Z460 1 +Single stranded telomeric dna binding 0.2290927412873744 0.0168197744440718 0.9865803944030388 1.0 1.0 7 P22626,P15927 2 +Camp dependent protein kinase inhibitor activity 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 +Camp binding 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P10644 1 +Fucosyltransferase activity 0.2955846279640315 0.0126802855222823 0.9898828670776204 1.0 1.0 2 Q9Y2G5 1 +Thyroid hormone receptor binding 0.3019506947554056 0.0110294751279797 0.9911999305024016 1.0 1.0 3 Q9Y2W1 1 +Hsp70 protein binding 0.2055538511041925 0.0097840194450955 0.9921936064895148 1.0 1.0 13 O75937,P06493,P31689,P46379,Q07812,P25685 6 +Extracellular matrix binding 0.241407528641573 0.0083788199898154 0.9933147471150828 1.0 1.0 4 P08865,P17931,P05556 3 +Laminin binding 0.241407528641573 0.0083788199898154 0.9933147471150828 1.0 1.0 4 P08865,P17931,P05556 3 +Chromo shadow domain binding 0.2654396728016288 0.007512440825068 0.9940059958321557 1.0 1.0 3 Q14739,Q13263 2 +Sequence specific single stranded dna binding 0.196877532661673 0.0038786731726214 0.9969052743187304 1.0 1.0 8 P22626,P15927 2 +Single stranded dna helicase activity 0.1912187115305666 0.0033876571125823 0.9972970458625272 1.0 1.0 11 P33991,P51530,P33992,Q14566,P35250,Q08211,P33993,P40937,P25205,P49736 10 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8ad32311d2f49aab082ce39a141dfd6a5740ac82 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5alpha androstane 3beta 17beta diol dehydrogenase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Basal transcription machinery binding", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium cation antiporter activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co receptor binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "D loop dna binding", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix constituent conferring elasticity", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Fatz binding", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione hydrolase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di methyl lysine 27 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "Hypoglycin a gamma glutamyl transpeptidase activity", "I smad binding", "Identical protein binding", "Ige binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Intermediate filament binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurotransmitter binding", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BCAP31", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf35", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC5", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFM", "NEK9", "NELFA", "NELFB", "NENF", "NEO1", "NEU1", "NFS1", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POFUT2", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RMDN1", "RMDN3", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC4A1AP", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM43", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSR1", "TSTA3", "TTC1", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "URB1", "UROD", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABRAXAS2", "ACOX1", "ACP6", "ACTN1", "ACTN2", "ADK", "ADRM1", "ADSL", "AIMP2", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "ALDH1B1", "ALG5", "ALKBH5", "ANAPC5", "ANKFY1", "ANKLE2", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "AP1B1", "AP1G1", "AP1M1", "AP2S1", "AP3M1", "APEX1", "APOC3", "APOL2", "APRT", "ARF4", "ARFGAP1", "ARHGDIA", "ARIH1", "ARL1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC4", "ATG3", "ATP6AP1", "ATPIF1", "ATXN2L", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BAX", "BLMH", "BSG", "C1QBP", "CAB39", "CACYBP", "CALD1", "CALM3", "CAP1", "CAPN1", "CAPN2", "CARHSP1", "CARM1", "CAST", "CCDC124", "CCDC6", "CCNB1", "CD2AP", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CFL2", "CHAF1B", "CHD1", "CHMP2A", "CIAPIN1", "CIRBP", "CLASP1", "CLTB", "CNN2", "CNN3", "CNOT9", "COPS2", "COPS5", "COTL1", "CPNE1", "CSE1L", "CTBP1", "CTNNA1", "CTNNB1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CTU2", "CUL5", "CUTA", "CWF19L1", "CYB5D2", "DAZAP1", "DCD", "DCTN1", "DCTPP1", "DDB1", "DDX6", "DERL1", "DFFA", "DHCR24", "DHFR", "DHX29", "DHX36", "DHX9", "DICER1", "DIS3", "DNA2", "DNAJA1", "DNAJB1", "DNAJC1", "DNAJC8", "DNAJC9", "DNM2", "DPF2", "DPP9", "DPYSL2", "DSC3", "DUSP3", "DYNC1I2", "DYNC1LI1", "EDF1", "EEA1", "EEF1B2", "EEF1D", "EFL1", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3H", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "EMC7", "ENSA", "EPDR1", "EPHX2", "EPS15", "ERI1", "EWSR1", "EXO1", "EXOC5", "EZR", "F11R", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FDPS", "FEN1", "FGFR1OP", "FKBP10", "FKBP4", "FKBP5", "FNTA", "FRG1", "FTO", "FUBP1", "FUS", "FXR2", "G3BP2", "G6PD", "GAMT", "GAPDH", "GATAD2B", "GCC2", "GCLC", "GDI1", "GGCX", "GGT7", "GIGYF2", "GPHN", "GRB2", "GSTM2", "GSTO1", "GTPBP1", "GYS1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HEATR3", "HECTD1", "HMGA1", "HMGB1", "HMGB3", "HNRNPA2B1", "HNRNPK", "HS2ST1", "HSP90AA1", 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erythrocyte sedimentation rate 2 7 2.271602673866405 0.0231105192513849 2.0194174757281553 7.453883495145631 0.5571011197666136 0.4379868786045082 1.3382395516344137 1.3439217593165471 0.953191146063846 0.2915576772081248 1.0 0.0738393547118652 0.000950200979251 0.018305800105915 0.0301952715566326 +Abnormality of the parathyroid gland 1 15 2.246143831742582 0.0246947965850019 4.699029126213592 20.546116504854368 0.6237618755864083 0.5009535063764416 2.3712884190123216 2.9764952130680324 0.9346790271256726 0.3344585569453652 1.0 0.0120821297793307 0.0688404632475066 0.353332903426898 0.1228138811636675 +Malignant neoplasm of the central nervous system 5 18 2.223001779148649 0.026215680003967 6.453883495145631 23.82766990291262 -0.1035875416121286 0.5489059085312997 4.178110952578651 3.916843315852553 0.9853841716312314 0.3143838966418644 1.0 0.0198262459954122 0.0182961528204827 0.2180247724103086 0.0546012419267142 +Toxemia of pregnancy 1 5 2.215310617836147 0.0267387515588697 1.4878640776699028 5.800970873786408 1.2181595126321945 0.2438445067902855 1.0938256996143263 0.5566883958063523 0.8280220660434614 0.2316195823412623 1.0 0.0347606010038453 0.0869978059975285 0.026979757634231 0.1038862441468568 +Glioma 1 9 2.18181366568894 0.0291232875910143 4.390776699029126 13.74757281553398 -0.1545508609455253 0.4389667761549956 2.91634369747243 2.676646382387555 1.1838681266493505 0.3197424323829116 1.0 0.007332807406421 0.0434222212102392 0.2485650807277314 0.3334875669704562 +Neoplasm of the adrenal cortex 1 5 2.1808400948680684 0.0291952458264517 1.9029126213592231 5.502427184466019 0.279284275131131 0.3518731642920829 1.1804603603119783 0.9766665776615882 1.363400785954724 0.3120205744103949 1.0 0.0011074252764693 0.0071140696266867 0.0517895754631345 0.1845383204790011 +Astrocytoma 1 5 2.1584153173584824 0.0308955558772356 3.063106796116505 8.995145631067961 -0.0406188385045949 0.4101166468994238 2.099675901539857 2.070358471881757 1.2750952497401025 0.3317381378473951 1.0 0.0022188527894044 0.0139536818673555 0.0952782699863604 0.3059455552422405 +Abnormal motor nerve conduction velocity 2 13 2.151940066748884 0.0314020750430852 4.25 20.558252427184467 0.4097033673292805 0.5168820746224434 2.874076466272354 3.062298910278382 0.8700343666746154 0.2942167990911473 1.0 0.1244363327921815 0.0046795081699748 0.074170908396053 0.3463350727570705 +Distal lower limb muscle weakness 1 10 2.1401080155724874 0.032346038463034 4.344660194174757 17.815533980582526 0.1186580396731779 0.5383160781021461 2.7593874427650213 2.6059959720089503 0.9262387077523402 0.2986056584700273 1.0 0.1347425270434581 0.0527005247491891 0.2891280480643491 0.6695295372070315 +Abnormal pleura morphology 4 14 2.132384429195207 0.0329752563728709 5.830097087378641 21.546116504854368 0.7290082089123371 0.4905463652617658 2.6668163977506785 3.2642978200941286 0.7757959562897808 0.3157493889189873 1.0 0.2107347128254066 0.0224584654256734 0.2527960351648975 0.3117590162626833 +Early onset of sexual maturation 3 34 2.129737620275793 0.0331932812447652 9.75485436893204 42.38106796116505 0.0255629521708843 0.6824039617296911 4.685300368375371 5.347436626189173 0.732246597870455 0.2980522101053944 1.0 0.0073906055496792 0.0198409114730037 0.3488303480570883 0.1841346262788261 +External ear malformation 4 10 2.12320937807091 0.0337363104635461 4.601941747572815 16.150485436893202 0.4544567406276061 0.5535523589124485 2.277325146273446 3.3684248799873826 0.7806015398926209 0.3022731759787185 1.0 1.0 1.0 0.8093128750519787 0.2664411201801646 +Premature ventricular contraction 1 7 2.07900558062954 0.0376168375344034 1.480582524271845 6.645631067961165 0.3887689762072841 0.3497972460308874 1.4234893714961696 0.5447501786076202 1.2366408357670695 0.2803988641190083 1.0 0.0204213541725399 0.051696017715171 0.0092212502645231 0.0384691498257934 +Neoplasm of the endocrine system 3 30 2.008700454851187 0.044568910463461 9.281553398058252 39.21601941747573 -0.1320464774870864 0.6293850541497769 5.5540896778915325 4.9545934046547355 0.7512360229380008 0.2880697421946374 1.0 0.0412351214457157 0.0503177214068148 0.2181184363652549 0.4006103106545656 +Clubbing 6 14 2.002376214831388 0.0452442846103213 6.716019417475728 18.652912621359224 -0.657540732591027 0.4705998370031453 3.4696234763420835 3.142013494272457 0.9762632484516656 0.3312049785139436 1.0 1.0 0.4683377286532528 0.5428948892539307 0.0891247406113362 +Supernumerary spleens 1 6 1.9966324894357 0.0458651207884179 2.4635922330097086 8.893203883495145 0.2587721830181201 0.5939990004505965 1.7752709922324543 1.6155351474977115 0.77389712276353 0.2958192888392422 1.0 0.1347425270434581 0.0527005247491891 0.2891280480643491 0.6695295372070315 +Breast carcinoma 1 16 1.9913889514886047 0.046438142960298 5.269417475728155 21.303398058252423 0.0458449363367184 0.5512715013731206 3.6487445174839737 3.8323720894298465 0.9809579775350368 0.3254016536425757 1.0 0.013753289442188 0.0774450438131048 0.147183744828707 0.3122349419967216 +Skin ulcer 2 23 1.99066855374311 0.046517338061893 6.660194174757281 29.611650485436893 0.3066149117240137 0.5927331806895341 3.4684525467551492 3.2041629769245414 0.8556736681910342 0.3230060576991134 1.0 0.0011955720259404 0.0170138500609331 0.2066661418338308 0.1155132693254731 +Neoplasm of the breast 1 22 1.990044501824688 0.0465860334941712 6.725728155339806 28.038834951456312 0.0356761006774126 0.6192223775535868 4.16469421060515 4.780974288522818 0.8421728870494568 0.3094296183049012 1.0 0.0229448160094258 0.1222451629768949 0.2527960351648975 0.3117590162626833 +Abnormality of the female genitalia 20 104 1.986586036642309 0.0469682898587775 25.783980582524272 131.41747572815535 0.0451404802101303 0.809599465116913 10.342176616393258 15.403331043001208 0.5489445274939192 0.2710985717624184 1.0 0.3521243767155744 0.0970945037205271 0.3078836505079551 0.3040455804133569 +Skin rash 3 15 1.9848438953776368 0.0471618420704671 4.308252427184466 19.490291262135923 0.4406644545054502 0.5522135269042797 2.5293672900029422 2.9233580426050203 0.8255562489362827 0.3065503861718416 1.0 0.174806977121525 0.0014363946692659 0.05287755096896 0.1816536732441257 +Abnormality of the ovary 9 48 1.977781076911717 0.047953409138588 13.131067961165048 60.98543689320388 0.0189933286617668 0.7395958825430006 5.819477324913906 8.053810625152751 0.6409320709274551 0.2867048678337134 1.0 0.1089271140903044 0.05706412310981 0.2408681266276427 0.1795355391447917 +Arterial stenosis 0 12 1.9762634516007815 0.0481249467423601 3.703883495145631 14.097087378640778 -0.1012288199392378 0.6674696362750959 2.243585130734692 2.232872515836187 0.6964074865780938 0.2833589826178254 1.0 0.1698987766424285 0.3806247653579538 0.7512107682628815 0.9499852724289056 +Accessory spleen 1 5 1.9725906242683744 0.0485422220637694 1.966019417475728 6.861650485436893 0.274531928254225 0.5475741379706007 1.4172346516633685 1.1732393105335834 0.8284916786232522 0.288909257936624 1.0 0.0683518202938552 0.0139536818673555 0.0952782699863604 0.3059455552422405 +Upper limb amyotrophy 3 11 1.9712018317551785 0.0487007944945552 3.6140776699029127 15.228155339805824 0.1985726352692081 0.575425256148584 2.1798048976974154 1.8476916838027435 0.8457497344245837 0.2995252599352756 1.0 0.1166289149301877 0.0399023057865369 0.062866738527989 0.1281015195962867 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f44cbd86aeb660b6f26b4ca547b196d085f4e14c --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 4420, + "title": "Average number of proteins per term", + "value": 18.945927601809956 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c204cdcc236268c97fb4f1b8cb9918ebb8328001 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..562677c5e969e2df3bb2056b9f4b76dec18e2137 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1007 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Micromelia 0.711916095583448 2.7216378491127156 0.0064959286436068 0.999999999999691 0.2310018633362672 18 P48735,O75874 2 +Abnormal cartilage morphology 0.7966481118083588 2.6428441395901348 0.0082212870340774 1.0 0.2506075082111879 11 P48735 1 +Recurrent fractures 0.6159240299524985 2.6139310999624894 0.0089507084663034 1.0 0.2579586147128404 26 Q9Y2U8,P48735,O75874,Q9UNW1,P40763,O75718,Q96AY3,Q13126 8 +Abnormal thyroid morphology 0.5779285341913404 2.5329342038234155 0.011311218243293 1.0 0.2683793602898085 31 Q9UPY3,P48735,Q9UNW1,O75874 4 +Neoplasm of the pituitary gland 0.7657379803965112 2.497520275879291 0.0125065312739702 1.0 0.2683793602898085 11 P48735 1 +Goiter 0.9113911462072868 2.4812414069617184 0.0130925669705885 1.0 0.2683793602898085 6 Q9UPY3,P48735,O75874 3 +Pituitary adenoma 0.803783786891925 2.453064258151653 0.0141645033226618 1.0 0.2769259582890905 9 P48735 1 +Abnormal astrocyte morphology 0.7739788328233155 2.423869195198963 0.0153561354728106 1.0 0.2876021982619626 10 P48735,O75874 2 +Venous thrombosis 0.736489345916171 2.409842344878456 0.0159594152593567 1.0 0.2937793288685573 12 P48735,O75874 2 +Lower limb amyotrophy 0.7236998070047111 2.403041923329904 0.0162593232975567 1.0 0.2937793288685573 13 O00400,Q9NR77,P04792 3 +Enchondroma 0.7849518823901627 2.3688978552649655 0.0178411800126307 1.0 0.2938888378985884 9 P48735 1 +Ovarian neoplasm 0.6448799578831425 2.342383884386349 0.0191609952157387 1.0 0.3072374751323968 18 Q9UPY3,P48735,Q01844,O75874 4 +Distal lower limb amyotrophy 0.7754524121809285 2.326120015818426 0.0200121490390685 1.0 0.3109968687633396 9 Q9NR77,P04792 2 +Gonadal neoplasm 0.6045006700957039 2.3243393036130744 0.0201073158658595 1.0 0.3109968687633396 21 Q9UPY3,P48735,Q01844,O75874 4 +Cerebral palsy 0.7727383573420139 2.313858523927097 0.0206754838676199 1.0 0.3109968687633396 9 P48735 1 +Serositis 0.6390110388731647 2.3083893167534364 0.0209774926551029 1.0 0.3109968687633396 18 P14174,P52565,Q9NQW6,Q8NFH4,O15460 5 +Multiple enchondromatosis 0.8665816388923471 2.302199678325476 0.0213239141149925 1.0 0.3109968687633396 6 P48735 1 +Ectrodactyly 0.7118081641637343 2.288009615624546 0.0221369611562671 1.0 0.313642302371484 12 Q13363,Q9NR77,P04792 3 +Abnormal erythrocyte sedimentation rate 0.8324026424085035 2.2716026738664055 0.0231105192513849 1.0 0.3162723981323345 7 P14174,O15460 2 +Abnormality of the parathyroid gland 0.6696964407453454 2.246143831742582 0.0246947965850019 1.0 0.3165937311954486 15 P48735 1 +Malignant neoplasm of the central nervous system 0.6243654724996613 2.223001779148649 0.026215680003967 1.0 0.3165937311954486 18 P48735,O75874,Q9UPY3,P43246,Q06124 5 +Toxemia of pregnancy 0.8902697387506454 2.215310617836147 0.0267387515588697 1.0 0.317518432335418 5 O43772 1 +Pericarditis 0.9620651465657282 2.213046492168687 0.026894440506116 1.0 0.317518432335418 4 O15460 1 +Glioma 0.7437531297139868 2.18181366568894 0.0291232875910143 1.0 0.3272382374937446 9 P48735 1 +Neoplasm of the adrenal cortex 0.8815293890683611 2.1808400948680684 0.0291952458264517 1.0 0.3272382374937446 5 P48735 1 +Astrocytoma 0.8758608739098006 2.1584153173584824 0.0308955558772356 1.0 0.3272382374937446 5 P48735 1 +Neoplasm of the parathyroid gland 0.9464567844384224 2.1542384819412113 0.0312214744628871 1.0 0.3272382374937446 4 P48735 1 +Abnormality of the parathyroid morphology 0.9464567844384224 2.1542384819412113 0.0312214744628871 1.0 0.3272382374937446 4 P48735 1 +Parathyroid adenoma 0.9464567844384224 2.1542384819412113 0.0312214744628871 1.0 0.3272382374937446 4 P48735 1 +Abnormal motor nerve conduction velocity 0.6743943053820438 2.151940066748884 0.0314020750430852 1.0 0.3272382374937446 13 Q9NR77,P04792 2 +Distal lower limb muscle weakness 0.7135344829780539 2.1401080155724874 0.032346038463034 1.0 0.3272382374937446 10 P04792 1 +Abnormal pleura morphology 0.659898004515354 2.132384429195207 0.0329752563728709 1.0 0.3272382374937446 14 Q9UPY3,P14174,O15460,Q06124 4 +Early onset of sexual maturation 0.5095759065905745 2.129737620275793 0.0331932812447652 1.0 0.3274872837095146 34 P48735,Q5JRA6,O75874 3 +External ear malformation 0.709995992946387 2.12320937807091 0.0337363104635461 1.0 0.3291710645670511 10 Q9BXW9,Q15813,P41227,Q15555 4 +Premature ventricular contraction 0.7867928698111674 2.07900558062954 0.0376168375344034 1.0 0.3474900833041289 7 O43772 1 +Exostoses 0.92323122332676 2.0660809659136317 0.0388208351722747 1.0 0.355991890998868 4 P48735 1 +Limb fasciculations 0.9221741124011906 2.062050234618738 0.0392029535899898 1.0 0.3580104439416425 4 Q92734,P04792 2 +Neoplasm of the endocrine system 0.5107383257711924 2.008700454851187 0.044568910463461 1.0 0.3900882856405894 30 Q9UPY3,P48735,O75874 3 +Clubbing 0.6355378668758925 2.002376214831388 0.0452442846103213 1.0 0.3924023150381551 14 Q9H4L7,Q9BXW9,Q86TI2,Q96AX1,P09884,Q9NVI1 6 +Supernumerary spleens 0.7921897798796096 1.9966324894357 0.0458651207884179 1.0 0.3924023150381551 6 Q15904 1 +Breast carcinoma 0.6117253027752168 1.9913889514886052 0.046438142960298 1.0 0.3924023150381551 16 P48735 1 +Skin ulcer 0.5421249608473802 1.99066855374311 0.046517338061893 1.0 0.3924023150381551 23 P48735,O75874 2 +Neoplasm of the breast 0.5472199269886868 1.9900445018246875 0.0465860334941712 1.0 0.3924023150381551 22 P48735 1 +Abnormality of the female genitalia 0.363541985323415 1.986586036642309 0.0469682898587775 1.0 0.3924023150381551 104 P48735,O75874,P43246,Q06124,Q13363,Q8WX93,Q15645,Q15392,Q9BW83,Q9UPY3,Q9UNW1,P22570,Q15042,Q92766,Q9UI10,Q03252,Q9NR50,Q9BXW9,Q01844,O75312 20 +Skin rash 0.621691419488628 1.9848438953776368 0.0471618420704671 1.0 0.3924023150381551 15 P14174,Q06136,Q9H4L7 3 +Abnormality of the ovary 0.4446907663836661 1.977781076911717 0.047953409138588 1.0 0.3924023150381551 48 Q8WX93,P48735,O75874,Q9BW83,Q03252,Q9NR50,Q01844,Q9UPY3,P43246 9 +Accessory spleen 0.8293975847842052 1.9725906242683744 0.0485422220637694 1.0 0.3936818743520385 5 Q15904 1 +Upper limb amyotrophy 0.6580891437475171 1.9712018317551785 0.0487007944945552 1.0 0.3942445268606851 11 Q9NR77,O60568,P04792 3 +Abnormal protein glycosylation 0.6742548063857111 1.9507819706372076 0.0510829874557725 1.0 0.4112692250537608 10 Q15904,Q8N511,P36871 3 +Hyporeflexia of lower limbs 0.753751430555188 1.936926080796186 0.0527543798345035 1.0 0.419954473413463 7 P04792 1 +Lymphangioma 0.9975470155355683 1.9195633405162775 0.0549130783563431 1.0 0.4273165604490086 2 P48735 1 +Visceral angiomatosis 0.9975470155355683 1.9195633405162775 0.0549130783563431 1.0 0.4273165604490086 2 P48735 1 +Hemangiomatosis 0.9975470155355683 1.9195633405162775 0.0549130783563431 1.0 0.4273165604490086 2 P48735 1 +Decreased circulating iga level 0.7727556787090983 1.9151389397215903 0.0554747869886369 1.0 0.427920695444634 6 Q15904 1 +Ectopia pupillae 0.8141485106016679 1.9108415512629084 0.0560249461585091 1.0 0.4299136493413377 5 P61586 1 +Abnormal glial cell morphology 0.4415886422340682 1.9065270744186849 0.056581856438246 1.0 0.4299555348171611 45 P48735,Q92734,Q9H9B1,O75874,P35637,Q13148,Q9NR50,O95831,Q04637,Q6Y7W6,P43246 11 +Abnormal vitamin b12 level 0.8129640778501076 1.9060301111323947 0.0566462990953062 1.0 0.4299555348171611 5 P41440 1 +Pleural effusion 0.7464999698571207 1.9054663725766312 0.0567194746265129 1.0 0.4299555348171611 7 P14174,Q06124 2 +Somatic mutation 0.4567721072106183 1.9024928784798856 0.0571067489976229 1.0 0.4299555348171611 39 O75874,Q9UNW1,Q01844,P61586,Q9UPY3 5 +Prenatal maternal abnormality 0.6616922440692803 1.889441883445066 0.0588326431848558 1.0 0.4385164972631749 10 O43772 1 +Neoplasm of the adrenal gland 0.6409847397328448 1.8847411827289688 0.0594647893512449 1.0 0.4413493901005961 11 P48735 1 +Neoplasm of the skeletal system 0.4540883995540098 1.8792885890091564 0.060205098944027 1.0 0.4449942095862868 39 Q5TBB1,P48735,O75874,P43246,Q92804,Q13126,Q06124 7 +Skin nodule 0.5775830053226343 1.867442661406739 0.0618397969532269 1.0 0.4527612343509461 17 P48735,P34913,O75874 3 +Platyspondyly 0.4923886788659214 1.8453051929600848 0.0649931555088467 1.0 0.4603681848543313 29 Q96AY3,P48735,Q5JRA6,O75874 4 +Increased susceptibility to fractures 0.4360411538782313 1.843693284582424 0.0652278522623619 1.0 0.4605820629290393 44 P48735,Q9Y2U8,O75874,Q9UNW1,O60568,P40763,O14745,O75718,Q96AY3,Q13126 10 +Somatic mosaicism 0.9771054783319708 1.837824468875067 0.0660882748012676 1.0 0.4651435901617883 2 P61586 1 +Ulnar claw 0.9766966475878992 1.8361858500039496 0.0663301746879982 1.0 0.466103930239988 2 P04792 1 +Abnormality of coagulation 0.4434096725801994 1.832098629376804 0.0669367275477257 1.0 0.4662211941437431 40 O75340,P48735,O75874,O75352,P40763,P38435,Q96AX1,P36871 8 +Decreased circulating igg level 0.6637740287463378 1.8073212913734047 0.0707121981718714 1.0 0.4766809146103151 9 Q15904,Q96AX1 2 +Abnormal metabolism 0.460170231222223 1.8068093589891636 0.0707920089597404 1.0 0.4766809146103151 36 O75340,Q8N511,P41440,Q9UDY2,Q15904,P36871 6 +Foot dorsiflexor weakness 0.5195893936360355 1.8062479452836229 0.0708796188477474 1.0 0.4766809146103151 22 Q99720,Q9NR77,P04792 3 +Talipes equinovarus 0.4176149358096737 1.8053590762719096 0.071018510679766 1.0 0.4766809146103151 53 Q13363,Q9NR77,Q9H9B1,P04792,Q15392,P11047,O60568,Q9H3P2,Q96AY3 9 +Nodular goiter 0.9689288634505316 1.8050251168357276 0.071070751748461 1.0 0.4766809146103151 2 Q9UPY3 1 +Impaired pain sensation 0.5873975133469884 1.7939331973872077 0.0728238319705916 1.0 0.4832473494030734 15 Q9NR77,P04792 2 +Asthma 0.5750804334378146 1.782030904914144 0.0747441920953897 1.0 0.4898961369906749 16 Q5JRA6,Q92766,Q08J23,Q9H3U1 4 +Neonatal onset 0.5492579310873674 1.7730346947044875 0.0762229580175122 1.0 0.4919241148594478 18 Q9H4L7,P11047,Q9UDY2,Q15904,P40763 5 +Type i diabetes mellitus 0.6380421900475188 1.7729788331895846 0.0762322143492997 1.0 0.4919241148594478 10 Q5JRA6,Q96J02 2 +Vasculitis 0.7155070564967638 1.7699295561104833 0.0767388764493479 1.0 0.4919241148594478 7 O15143,O15460 2 +Abnormal glycosylation 0.601804274745191 1.7696664465394096 0.076782722591481 1.0 0.4919241148594478 13 Q15904,Q8N511,P36871 3 +Abnormal pupil morphology 0.6103572549169378 1.769531786849295 0.076805170981868 1.0 0.4919241148594478 12 Q13363,P61586,Q9NR77 3 +Slowly progressive 0.4265967354688435 1.767739315676357 0.0771044940740812 1.0 0.4919241148594478 45 O75340,Q99720,Q92734,Q9NR77,P04792,Q9Y281,P41440,Q14203,P51530,O95831,P23381,Q16637 12 +Fatiguable weakness of proximal limb muscles 0.8458284402575611 1.766976898730959 0.0772320972088445 1.0 0.4919241148594478 4 Q92734 1 +Generalized hirsutism 0.5480268035762904 1.765501137152229 0.0774795792864162 1.0 0.4919241148594478 18 Q15042,Q06136,Q9BW83,Q03252 4 +Abnormal circulating iga level 0.6545497842557493 1.763226133172531 0.0778623578523614 1.0 0.4919241148594478 9 Q15904 1 +Oromandibular dystonia 0.958299264104661 1.7623047067769593 0.078017829076125 1.0 0.4919241148594478 2 Q99720 1 +Axial dystonia 0.958299264104661 1.7623047067769593 0.078017829076125 1.0 0.4919241148594478 2 Q99720 1 +Retrocollis 0.958299264104661 1.7623047067769593 0.078017829076125 1.0 0.4919241148594478 2 Q99720 1 +Limb undergrowth 0.4345466070251353 1.7535405394792816 0.0795092672524819 1.0 0.4957771233062406 40 P48735,O75874 2 +Cerebral white matter hypoplasia 0.7702684939226936 1.7311928090220197 0.0834173814941872 1.0 0.5080402049151549 5 Q9Y320,P22570 2 +Vertebral wedging 0.9501226492232226 1.7293847216394969 0.0837402626071246 1.0 0.5089395109134106 2 Q96AY3 1 +Abnormal circulating igg level 0.6069911841959968 1.710792235268818 0.0871194734783529 1.0 0.5196600172392981 11 Q15904,Q96AX1,P17812 3 +Ventricular tachycardia 0.6049068440969718 1.7000403003460591 0.089123345356022 1.0 0.5232532641112412 11 P41227,O43772 2 +Genital neoplasm 0.4593621214697194 1.6990601817637911 0.0893078448606747 1.0 0.5232532641112412 33 Q9UPY3,P48735,Q01844,O75874 4 +Abnormal protein o linked glycosylation 0.9593275508998704 1.6982571355052138 0.0894592410843848 1.0 0.5232532641112412 3 Q15904 1 +Abnormal head movements 0.6223287221877911 1.6949256151901129 0.0900895325766186 1.0 0.5232532641112412 10 Q99720,Q14353,P35637 3 +Complete duplication of phalanx of hand 0.8271109915883524 1.6935361051909883 0.0903534684419744 1.0 0.5240975466056785 4 Q9BXW9,P41227 2 +Premature loss of teeth 0.6203894967769001 1.6852577451986062 0.0919388543239212 1.0 0.528439188701862 10 Q5JRA6 1 +Degeneration of the lateral corticospinal tracts 0.7167205046417158 1.6766005896203082 0.093620611405131 1.0 0.5332514206323183 6 O00400,Q14203,P35637 3 +Abnormal epidermal morphology 0.5451768021215034 1.675010314416745 0.0939322079562492 1.0 0.53380923826855 17 P52732,Q9H4L7,P20810,O75352,Q06136 5 +Mediastinal lymphadenopathy 0.9523891463810316 1.6726024702026543 0.094405580298766 1.0 0.5349649550263407 3 O15460 1 +Chondrosarcoma 0.9501022494887488 1.6641394933249904 0.0960845563121464 1.0 0.539606083652811 3 P48735,O75874 2 +Hamartoma 0.5734589756376951 1.663555627188703 0.0962012655924016 1.0 0.539606083652811 14 P48735 1 +Abnormal preputium morphology 0.7513183059155486 1.652779354206628 0.0983757773720568 1.0 0.5438623721071325 5 Q9BXW9,O60828 2 +Vascular neoplasm 0.4656728801626301 1.6439562472728222 0.1001852403098904 1.0 0.5473655898265953 29 Q13363,P48735,O75874 3 +Abnormal circulating lipid concentration 0.3909891501575593 1.619199163763937 0.1054044178837656 1.0 0.5584738586644042 57 Q8N511,P02656,P34913,O43772,Q15392,Q15904 6 +Abnormal circulating cholesterol concentration 0.4830240193920774 1.6189889850915156 0.1054496331070944 1.0 0.5584738586644042 24 Q15904,Q8N511,P02656,P34913 4 +Abnormal morphology of the musculature of the neck 0.6241607745922225 1.6167844893841758 0.1059248086430755 1.0 0.5584738586644042 9 Q99720,P35637 2 +Sarcoma 0.3947700546889258 1.6154403553834669 0.1062153669611472 1.0 0.5584738586644042 55 P48735,O75874,Q15392,Q01844,Q9UPY3,P43246,Q92804,Q13126,Q06124 9 +Rhabdomyolysis 0.5881935046541585 1.613495593283191 0.1066368798753014 1.0 0.5584738586644042 11 O43772,P43897 2 +Proximal amyotrophy 0.6223559450395288 1.6080345071515916 0.1078276214684001 1.0 0.5584738586644042 9 Q92734,Q16637,P35637 3 +Metatarsus adductus 0.6047290276304816 1.6069168307814945 0.1080726137867225 1.0 0.5584738586644042 10 Q13363,Q15392,Q03252 3 +Megaloblastic anemia 0.6769269107194827 1.5989613202891575 0.1098291973728164 1.0 0.5584738586644042 7 Q99707,P00374,P41440 3 +Cutaneous syndactyly 0.6762987656893543 1.5961590789667637 0.1104532812062151 1.0 0.5590505722279906 7 P21281,Q9Y2U8,Q9H4L7 3 +Hydroureter 0.619755223908667 1.5954163203528555 0.1106191688315503 1.0 0.5590505722279906 9 Q9BXW9,P41227,Q9NVI1 3 +Areflexia of lower limbs 0.560467126435941 1.5914353266046912 0.1115116393573076 1.0 0.5607297451186576 14 Q9NR77,P04792 2 +Congenital malformation of the right heart 0.7345976534325878 1.583223924034841 0.1133704354061329 1.0 0.56314574808161 5 P21281,Q8N3U4,O15460 3 +Abnormal circulating sulfur amino acid concentration 0.6722092093636762 1.5779016679466953 0.1145882017679809 1.0 0.56314574808161 7 P55263,P41440 2 +Aplasia hypoplasia of the cerebral white matter 0.6910913398764255 1.565922715222236 0.117366711296069 1.0 0.5681937173369388 6 Q9Y320,P22570 2 +Abnormality of the metaphysis 0.4346887887884663 1.5606164989028728 0.118614263547526 1.0 0.5713003222471306 35 P48735,O75874,O95831,Q96AX1,Q13126,Q06124 6 +Titubation 0.6402261541225567 1.5597841400673262 0.1188109006304021 1.0 0.5714300117370809 8 Q99720,Q9NWX6 2 +Abnormal muscle glycogen content 0.7929556389745809 1.5585984411696472 0.1190914522282517 1.0 0.5715355253516535 4 O75648,Q9BUK6 2 +Neck flexor weakness 0.9198364008179932 1.5518400205231313 0.1207005073888947 1.0 0.5743380812309924 3 Q99720,P35637 2 +Abnormality of lipoprotein cholesterol concentration 0.5763492901487831 1.5518323843548398 0.1207023349946734 1.0 0.5743380812309924 11 P02656,P34913 2 +Epidermal acanthosis 0.6107642904507481 1.5517093206911885 0.1207317914791259 1.0 0.5743380812309924 9 Q06136 1 +Tachycardia 0.4826218080820386 1.5298850324857798 0.126045188831402 1.0 0.5767187027090296 21 P41227,P0DP25,O43772,P36871 4 +Torsade de pointes 0.9006541291905161 1.5293847940194398 0.1261690798249644 1.0 0.5767187027090296 2 P41227 1 +Abnormality of exocrine pancreas physiology 0.5207536452296894 1.5281334571024046 0.1264794061157883 1.0 0.5767187027090296 17 Q15904,Q8WX93,P14174 3 +Lymphocytosis 0.785016986151593 1.5270876470568002 0.1267392182310263 1.0 0.5769179655830445 4 Q03252,Q5TBB1 2 +Abnormal circulating ceruloplasmin concentration 0.9119823365906384 1.5226216232646794 0.1278533967735882 1.0 0.5784155718927941 3 Q8N511 1 +Abnormality of pain sensation 0.4814405069088492 1.5219313048637872 0.1280262942503083 1.0 0.5786055425218434 21 Q9NR77,P04792 2 +Abnormal cd4 cd8 ratio 0.7834620139477895 1.5209098627710071 0.1282824585751099 1.0 0.5788183780617215 4 P17812 1 +Contractures of the joints of the upper limbs 0.3916989108024158 1.513516063171672 0.1301486240593643 1.0 0.5816551247142471 51 Q99720,Q9NR77,Q9H4L7,P35637,Q15392,P41227,P57081,O60568,Q15042,Q96AY3 10 +Abnormal dentin morphology 0.7796433158768081 1.505731023228125 0.1321362366038556 1.0 0.5832561517108706 4 Q96AY3 1 +Immunologic hypersensitivity 0.4659596452085566 1.4985944294248046 0.1339788787484086 1.0 0.587392204360291 24 O14646,P40763,Q08J23,Q9H3U1,Q92766,Q5JRA6 6 +Profound sensorineural hearing impairment 0.7771500627394761 1.4958151403579012 0.1347018347794264 1.0 0.5886138873844409 4 Q9NR77,P35241 2 +Narrow foot 0.890433360588718 1.48794563425974 0.1367652316025098 1.0 0.5914895535059624 2 P55263 1 +Abnormal ldl cholesterol concentration 0.5804245363376495 1.4844845682612209 0.1376804141032654 1.0 0.5942845999379233 10 P02656,P34913 2 +Abnormal circulating methionine concentration 0.7091997032932397 1.4770018431709515 0.139675143203013 1.0 0.5999651437874804 5 P55263 1 +Joint stiffness 0.3939275445178544 1.4610690483857436 0.1439964933002286 1.0 0.6107501940291062 45 Q96AY3,P48735,O75874 3 +Tremor by anatomical site 0.4756822395271343 1.4601506310784829 0.1442486800807803 1.0 0.6107501940291062 20 Q99720,Q9NR77,Q92734,P35637 4 +Acute phase response 0.4867933159596778 1.4562129071924268 0.1453337725425529 1.0 0.6126373352798626 19 P28070,P14174,O15460 3 +Steppage gait 0.5361422409402734 1.4555084808559136 0.1455285440772604 1.0 0.6126373352798626 14 P04792 1 +Osteolysis 0.4547482908147761 1.4503630750774077 0.1469572983407627 1.0 0.616818144863613 25 P48735 1 +Distal muscle weakness 0.388127216628075 1.450110753301734 0.1470276369079637 1.0 0.616818144863613 49 O75340,Q99720,P04792,P41440,P35637,P11047,O95831,Q9NR77 8 +Diffuse mesangial sclerosis 0.5177433787554259 1.447348863507543 0.1477992400862924 1.0 0.6180005722746077 16 P11047,P52565,Q9NQW6,Q9P2R3,Q8NFH4,O95470,Q9NPF4,Q9Y5K6 8 +Abnormal duodenum morphology 0.5492091314138478 1.4449915332864292 0.1484602638392678 1.0 0.6180005722746077 12 Q15645,Q8N3U4,Q7LBC6,Q9BXW9,P98175,O60216,O43683,Q9NVI1,O43684 9 +Aplasia hypoplasia of the earlobes 0.6625372932024316 1.4416762920697908 0.1493937147887356 1.0 0.6189923421341906 6 Q92766 1 +Distal sensory impairment 0.430052947700866 1.437343685770747 0.1506203615785601 1.0 0.6221887833432113 32 O95831,Q9NR77,P04792 3 +Fibrous tissue neoplasm 0.5403519087870864 1.4360277526909535 0.15099444433827 1.0 0.6228379886215909 13 P21281,P52701,P10644,Q15392,Q12824,P43246,Q13126 7 +Tetany 0.6968629260978985 1.4251993423187514 0.1540995864092811 1.0 0.6268980428646119 5 Q92766 1 +Abnormality of the thoracic cavity 0.5848586591827859 1.4251237243184292 0.1541214398920636 1.0 0.6268980428646119 9 Q01844,Q12824,O15460 3 +Coxa vara 0.5507181666314523 1.4175949264289232 0.1563090622599903 1.0 0.6294039827644038 11 O95831,Q96AY3 2 +Neutropenia in presence of anti neutropil antibodies 0.6362934294700172 1.416676089122619 0.1565776509651457 1.0 0.6294039827644038 7 P40763,Q96J02 2 +Abnormality of the peritoneum 0.4916248747326315 1.4160167264203918 0.1567706072882271 1.0 0.6294039827644038 18 Q8WX93,P52565,Q9NQW6,Q8NFH4,Q01844 5 +Alopecia 0.4168770979546801 1.4123862363522897 0.1578362668621444 1.0 0.6324898454493912 35 P61586,Q06136 2 +Neoplasm of the nervous system 0.4130694343586595 1.4115446321568463 0.158084085036654 1.0 0.6329091085706621 36 Q9UPY3,P48735,O75874 3 +Panniculitis 0.633366299492158 1.403476802540281 0.1604747046859911 1.0 0.6361418786655433 7 P52732,P28070 2 +Dicarboxylic aciduria 0.4602285033445812 1.4024695567330063 0.1607750752057388 1.0 0.6366792683226258 22 P48735 1 +Abnormal glomerular mesangium morphology 0.4997769851628629 1.4009958506750309 0.161215313907268 1.0 0.637362868935711 17 P11047,P52565,Q9NQW6,Q9P2R3,Q8NFH4,O95470,Q9NPF4,Q9Y5K6,Q14C86 9 +Abnormal form of the vertebral bodies 0.3454028355006955 1.3896426432426898 0.1646374198337303 1.0 0.6401688058203885 70 Q13363,P48735,O75874,O95831,Q96AY3,Q15436,Q5JRA6 7 +Abnormal circulating igm level 0.5615937245440847 1.3890450150622031 0.1648190621234944 1.0 0.6401688058203885 10 Q15904,Q96AX1 2 +Subcutaneous nodule 0.5228176159268929 1.3806542521218106 0.1673852937682551 1.0 0.6450911326894521 14 P52732,Q9Y2U8,P48735,O75874,P35637,Q06124 6 +Profound hearing impairment 0.6857280104792193 1.378352718384218 0.1680944138896425 1.0 0.6450911326894521 5 Q9NR77,P35241 2 +Gangrene 0.5752913878314593 1.3781720565288698 0.1681501725156935 1.0 0.6450911326894521 9 P40763,O15460 2 +Scaling skin 0.5738742929871807 1.3712102310563892 0.1703094297602265 1.0 0.6484677833567088 9 P52732,P20810,O75352 3 +Spinal cord lesion 0.7455295554927394 1.36974955598533 0.1707650935076174 1.0 0.6489954542593889 4 O00400 1 +Abnormal cranial nerve physiology 0.3755766127850813 1.368209638258398 0.1712464655437187 1.0 0.6502657884048425 52 O75340,P48735,Q92734,Q9Y281,O75874,Q14203,P51530,P11047,Q9BXW9,Q9NR77 10 +Cough 0.4551434130911143 1.367466894022055 0.1714790072662422 1.0 0.650390616240905 22 Q92734,P41440,Q86TI2,Q9NR77,O15460 5 +Abnormality of the lymph nodes 0.4311446431431104 1.3616513125262035 0.1733079533111794 1.0 0.6513502064664343 28 Q8WX93,P14174,Q9UNW1,P40763,Q01844,P28070,O15460 7 +Gingival fibromatosis 0.8565004088307479 1.350339427904585 0.1769071306648864 1.0 0.6565319206875042 2 Q15392 1 +Ectodermal dysplasia 0.856500408830748 1.3503394279045844 0.1769071306648866 1.0 0.6565319206875042 2 Q9H4L7 1 +Abnormal placental membrane morphology 0.856500408830748 1.3503394279045844 0.1769071306648866 1.0 0.6565319206875042 2 Q9H4L7 1 +Severe hearing impairment 0.8565004088307444 1.350339427904571 0.1769071306648908 1.0 0.6565319206875042 2 Q06124 1 +Large fleshy ears 0.8556827473426003 1.34702592948125 0.1779718817988334 1.0 0.6569955219730684 2 P21281 1 +Glomerulonephritis 0.4906862587835437 1.3456925705540808 0.178401683369721 1.0 0.6569955219730684 17 Q03252,P52565,Q9NQW6,Q8NFH4,Q9Y5K6 5 +Abnormal shape of the palpebral fissure 0.5528498694076498 1.3445988458296043 0.178754816288998 1.0 0.6569955219730684 10 Q9BXW9,O14646,Q9H9B1 3 +Elevated creatine kinase after exercise 0.6776608806816484 1.344370074279296 0.1788287458917437 1.0 0.6569955219730684 5 P51530,O43772 2 +Small earlobe 0.677560205382839 1.3439457931847307 0.1789659163773209 1.0 0.6569955219730684 5 Q92766 1 +Hyperlipoproteinemia 0.5935077484216867 1.340714258907726 0.1800132432470462 1.0 0.6576851909151181 8 P02656,P34913 2 +Abnormal internal genitalia 0.3248517033030502 1.333342925996156 0.1824192928851666 1.0 0.6619813419970744 98 Q13363,Q8WX93,P48735,Q15645,O75874,Q9UI10,Q9BW83,Q9UNW1,Q03252,Q9NR50,Q9BXW9,Q92766,O75312,Q01844,Q9UPY3,P43246,Q06124 17 +Impaired temperature sensation 0.6741268886494234 1.3294741774900891 0.1836915795878022 1.0 0.6641264178867876 5 P04792 1 +Childhood onset 0.4266954483885426 1.3278137149904798 0.1842396549633447 1.0 0.6647491367505828 28 Q15813,Q15904,Q8N0X7,P40763,Q14331,Q9NR77,O15047 7 +Preaxial hand polydactyly 0.5902161583167429 1.325203399985471 0.1851036979935836 1.0 0.6651693862858858 8 Q13363,Q9BXW9 2 +Abnormal blistering of the skin 0.4969055913597108 1.3242075522446417 0.1854341233405048 1.0 0.6658154550487662 16 Q06136 1 +Cardiac arrest 0.4447657481836302 1.3206894255316894 0.1866049413931771 1.0 0.6667991262298112 23 O43772,O15460,P36871 3 +Positional foot deformity 0.3386673567931509 1.309992801985181 0.1901982706437417 1.0 0.6752195545417257 69 Q13363,Q96AY3,Q15392,P04792 4 +Hyperhomocystinemia 0.8544485301775747 1.308128141449582 0.1908298498683085 1.0 0.6752195545417257 3 P41440 1 +Increased circulating prolactin concentration 0.6685590111320723 1.3059965388536912 0.1915537345998896 1.0 0.6752195545417257 5 Q9BUK6 1 +Partial agenesis of the corpus callosum 0.5591791286134576 1.298927379321025 0.1939688525217469 1.0 0.6772056304471732 9 Q15392 1 +Prominent occiput 0.5845057455475662 1.2982799679497028 0.1941911474075097 1.0 0.6774466231580056 8 Q96J02 1 +Abnormal circulating monocarboxylic acid cocentration 0.6077392621530449 1.2876573728864895 0.1978652582530351 1.0 0.6832534699050119 7 Q7Z2Z2,Q9H3U1,Q9UDY2 3 +Axial muscle weakness 0.7201147936168824 1.268183027343134 0.2047325967264892 1.0 0.6945396140140311 4 Q9Y281 1 +Head titubation 0.6224782953807815 1.266232006974354 0.2054300315584225 1.0 0.6945396140140311 6 Q99720 1 +Alveolar ridge overgrowth 0.8356500408830787 1.2659373156893357 0.2055355253160364 1.0 0.6945396140140311 2 Q15392 1 +Muscle fibrillation 0.4988109561725037 1.2453588015773651 0.2129998900304541 1.0 0.7068014368878435 14 O95831,Q92734,P04792 3 +Spinal cord compression 0.8358944644653634 1.2389917513921531 0.2153485528162626 1.0 0.710859300558537 3 Q9UNW1 1 +Abnormality of the pituitary gland 0.3685690709040889 1.237874754949109 0.2157625043209399 1.0 0.711337193484782 47 P48735 1 +Membranoproliferative glomerulonephritis 0.8282910874897813 1.2362103923294734 0.2163803687495158 1.0 0.711337193484782 2 Q03252 1 +Recurrent staphylococcus aureus infections 0.8282910874897812 1.2362103923294734 0.2163803687495158 1.0 0.711337193484782 2 P40763 1 +Recurrent staphylococcal infections 0.8282910874897812 1.2362103923294734 0.2163803687495158 1.0 0.711337193484782 2 P40763 1 +Delayed eruption of permanent teeth 0.8347648261758561 1.2347865798374993 0.216909943244044 1.0 0.711337193484782 3 P21281,Q5JRA6 2 +Axonal degeneration 0.7107853336002243 1.2308950686132476 0.2183621122402197 1.0 0.7117775583196212 4 Q92734,Q6DKK2 2 +Abnormality of the hallux 0.3720857905465148 1.228968135097735 0.219083753409814 1.0 0.7127791494597918 41 Q13363,P61586,Q96J02,P04792 4 +Bone pain 0.4408510248522433 1.2274740900956689 0.219644454322585 1.0 0.7127791494597918 20 P48735,O75874 2 +Abnormal thrombosis 0.4313862452308448 1.2268482787713375 0.219879621180568 1.0 0.7127791494597918 23 P48735,O75874 2 +Diastema 0.6483339754280524 1.2206684753885757 0.2222115683468719 1.0 0.7161023839827314 5 Q8WXI9,O15347 2 +Skin appendage neoplasm 0.8295958113009894 1.2155524421397377 0.224155460082188 1.0 0.7169090114984088 3 Q9UPY3 1 +Hypercholesterolemia 0.5122700933209686 1.2149032778489517 0.2244029834787366 1.0 0.7169090114984088 11 Q15904,P02656 2 +Onion bulb formation 0.7067597741872381 1.2148107004009776 0.2244382987493298 1.0 0.7169090114984088 4 Q9NR77,P50570 2 +Nephritis 0.4385227828396015 1.2118866429184092 0.2255557758063344 1.0 0.7169718385078152 20 P35579,O95394,P52565,Q03252,Q9P2R3,Q9NQW6,Q8NFH4,Q96AX1,Q9Y5K6,Q14C86 10 +Amaurosis fugax 0.5411895313666347 1.2103050928033483 0.2261618441911776 1.0 0.7172027294838846 9 O15460 1 +Aplasia cutis congenita of scalp 0.6082745691058424 1.2038801622784323 0.228635900280584 1.0 0.7181030475937424 6 Q13363 1 +Abnormal conus terminalis morphology 0.5871149146524071 1.1942627235950911 0.2323752142051054 1.0 0.7227770326083006 7 Q13363 1 +Neoplasm of the respiratory system 0.5073491167323605 1.188918617277149 0.2344716932974622 1.0 0.7264886869292703 11 Q15645,Q01844,Q13263,Q9UPY3,P43246 5 +Papillary thyroid carcinoma 0.5605840208694179 1.1853896520014038 0.2358634212341404 1.0 0.7295425625296714 8 Q9UPY3 1 +Recurrent bacterial infections 0.4877933197897656 1.1831984689481894 0.236730499635438 1.0 0.7316917348961784 14 Q7Z2Z2,O95394,Q86Y56,Q15813,Q15904,P40763 6 +Nocturnal hypoventilation 0.8143908421913357 1.180186480988468 0.2379260546883723 1.0 0.733356458662905 2 Q9Y281 1 +Poikilocytosis 0.5197832464669494 1.1761413754437926 0.2395383864556231 1.0 0.733659998759494 10 Q05682,P11413,P41440,Q8NBF2 4 +Increased muscle glycogen content 0.8170854544374322 1.1690655147961562 0.2423772366025463 1.0 0.733659998759494 3 Q9BUK6 1 +Impaired mastication 0.5803767429827225 1.1637513173113196 0.2445248062040121 1.0 0.733659998759494 7 O15460 1 +Hypoventilation 0.5025318192301129 1.1634861381447656 0.2446323190216575 1.0 0.733659998759494 11 Q14203,P11047,Q9Y281 3 +Retinopathy 0.4279742218311145 1.1595100916890149 0.2462483254121192 1.0 0.733659998759494 21 Q13363,P52732,Q15555,P40763,Q9H3P2,Q5JRA6 6 +Wormian bones 0.4830909296189389 1.1566771847032316 0.2474042744818199 1.0 0.733659998759494 14 Q96AY3 1 +Portal fibrosis 0.6915301638615821 1.1540125372706558 0.2484950289461407 1.0 0.733659998759494 4 Q9H3U1,P55263 2 +Segmental peripheral demyelination remyelination 0.8078495502861865 1.1538923682364992 0.2485442984292505 1.0 0.733659998759494 2 Q9NR77 1 +Abnormality of the foot musculature 0.8078495502861833 1.1538923682364857 0.248544298429256 1.0 0.733659998759494 2 O14979 1 +Heterotaxy 0.6322380764424793 1.1527878045447222 0.2489974912435755 1.0 0.733659998759494 5 Q13363 1 +Abnormal cell proliferation 0.690671031096555 1.150586175672315 0.2499025229824074 1.0 0.733659998759494 4 Q96MG7,O95394,P17812 3 +Aplasia hypoplasia of the uvula 0.6311736386666122 1.1483020695497568 0.250843885069111 1.0 0.7337723176740376 5 Q9BXW9,Q9NVI1 2 +Abnormality of vitamin k metabolism 0.6891516430673834 1.1445277091673 0.2524048531880809 1.0 0.7363890766279324 4 Q7Z2Z2,Q9UDY2 2 +Abnormality of the alveolar ridges 0.6296113425673451 1.1417193062672035 0.2535707132089624 1.0 0.7378423649661711 5 P21281,Q15392 2 +Cystic hygroma 0.5931401703678594 1.1374674027161238 0.2553429440985715 1.0 0.7397596453850267 6 Q96S52,Q06124,P61978 3 +Hypoplasia of the iris 0.5921440371566999 1.1330990850966938 0.2571726455384828 1.0 0.7413261158155177 6 Q13363 1 +Hammertoe 0.4909819166574662 1.1314455955884222 0.2578675897286135 1.0 0.7415580654524867 12 Q9NR77 1 +Atrophy degeneration involving the corticospinal tracts 0.496349958891263 1.130864251312552 0.2581122317634108 1.0 0.741778975548944 11 O00400,Q14203,P35637 3 +Metaphyseal chondrodysplasia 0.6842855259794929 1.1251346310409325 0.2605319882472523 1.0 0.7477606415927632 4 O95831,Q7Z2Z2 2 +Abnormality of the columella 0.4943506181631277 1.1203188161336723 0.262577926577715 1.0 0.7492539932043258 11 Q9BTW9,P41227,O60828,Q96J02 4 +Demyelinating peripheral neuropathy 0.4940294644268567 1.1186251898886554 0.2633000724164058 1.0 0.7508298839229122 11 Q9NR77 1 +Amyotrophic lateral sclerosis 0.4749645219713938 1.1108790908446844 0.2666203967012048 1.0 0.7550985951917549 14 Q99720,Q14203,Q92804,P35637 4 +Minimal change glomerulonephritis 0.48027647820135 1.1052568059747068 0.2690483285405247 1.0 0.7588140438835231 13 Q9NQW6,Q8NFH4,P52565 3 +Abnormality of peripheral nerves 0.3878175067700024 1.0988831739567266 0.2718190267835612 1.0 0.762335087806688 32 O95831,Q99720,Q9NR77,P04792 4 +Distal upper limb amyotrophy 0.5177481597887965 1.0948827305928344 0.2735680157250859 1.0 0.76434082456318 9 Q9NR77,O60568 2 +Chronic neutropenia 0.6184831232269888 1.0948741824292836 0.2735717611898078 1.0 0.76434082456318 5 Q7Z2Z2,Q9Y3A5,Q9Y3C6 3 +Multiple cafe au lait spots 0.4893661250047279 1.0940429796926645 0.2739361285508637 1.0 0.7648753557768904 11 Q15645,P52701,Q9BXW9,Q9NVI1,P43246,O43683,O43684 7 +Proptosis 0.3648740130777828 1.0904519444874614 0.2755141108589674 1.0 0.7661914646414446 39 Q13363,Q13409,P41227,P57081,Q9BXW9,O60568,Q9H3P2,Q12824,O75718,Q9NVI1,Q96J02,Q06124 12 +Impaired antigen specific response 0.6171170480736112 1.089129916956183 0.2760965987343029 1.0 0.7661914646414446 5 Q96MG7,O95394,P17812 3 +Aplasia hypoplasia of the pubic bone 0.6745780468079743 1.0865022553518895 0.2772568436398381 1.0 0.7661914646414446 4 Q13363 1 +Hypoplastic pubic rami 0.6745780468079743 1.0865022553518895 0.2772568436398381 1.0 0.7661914646414446 4 Q13363 1 +Rib segmentation abnormalities 0.6745780468079743 1.0865022553518895 0.2772568436398381 1.0 0.7661914646414446 4 Q13363 1 +Abnormality of abdominal situs 0.6745780468079743 1.0865022553518895 0.2772568436398381 1.0 0.7661914646414446 4 Q13363 1 +Colon cancer 0.4704313873329507 1.0853601180981076 0.2777621889389021 1.0 0.7661914646414446 14 Q8WX93,Q15645,P52701,Q9UNW1,P43246,O43683,P39019 7 +Abnormal nerve conduction velocity 0.3927465137539318 1.0839677809829231 0.2783790844822487 1.0 0.7661914646414446 29 Q99720,Q9NR77,P04792 3 +Ragged red muscle fibers 0.482088903695148 1.0835691894943682 0.2785558578736784 1.0 0.7661914646414446 12 O75340,O95831,Q70HW3,Q9H2D1 4 +Cellulitis 0.6713587267147858 1.0737095397757062 0.2829528843537112 1.0 0.7705802519059788 4 P40763 1 +Peritonitis 0.4674109514554698 1.068371716654877 0.2853528699192107 1.0 0.7737363767227449 14 Q9NQW6,Q8NFH4,P52565 3 +Long fingers 0.3247335129894154 1.0675433953538622 0.2857265287277779 1.0 0.7737363767227449 64 Q13363,O43776,Q15555,Q9H4L7,Q9H9B1,P26196,O60828,Q03252,Q8WXI9,Q9H3P2,Q06136,Q92766 12 +Thick hair 0.611908213970598 1.0672425322222492 0.2858623310380639 1.0 0.7737363767227449 5 Q96AX1 1 +Large forehead 0.6692749484283937 1.0654348847339532 0.2866791774558588 1.0 0.7748335439196209 4 Q96AX1 1 +Dolichocephaly 0.4152789858670376 1.056462990389426 0.2907567407780127 1.0 0.7785880375747941 20 Q13363,P21281,Q9BXW9,Q9H3P2,Q9NVI1,Q96J02 6 +Limb joint contracture 0.3169606990598616 1.0560407652153632 0.2909495909146344 1.0 0.7785880375747941 75 O75340,Q99720,Q9NR77,Q9H4L7,P35637,Q15392,P41227,P57081,O60568,P40763,Q15042,Q96AY3 12 +Abnormality of the pulmonary veins 0.5745176735425296 1.0559138681381104 0.2910075675994232 1.0 0.7785880375747941 6 O75718,Q15392,P60953 3 +Intestinal malrotation 0.40985230985188 1.055080426946864 0.2913885429512746 1.0 0.7785880375747941 22 Q13363,Q9Y2U8,Q15392,O75312,Q92766 5 +Absent epiphyses 0.6665876840779261 1.0547708569585297 0.2915301362412408 1.0 0.7785880375747941 4 O60568 1 +Joint contracture of the hand 0.3795925681008213 1.053491645779728 0.2921157211593745 1.0 0.7787403422945932 33 Q9H4L7,Q15392,P41227,P57081,Q15042,Q9NR77 6 +Abnormality of the hypothalamus pituitary axis 0.343647110473479 1.0484372862482032 0.2944371822053417 1.0 0.7799857324437826 52 P48735 1 +Abnormal phalangeal joint morphology of the hand 0.4024686762090216 1.046570236339235 0.2952978352642355 1.0 0.7800982020530278 24 P41227,Q9H4L7,P57081 3 +Punctate cataract 0.7804578904333654 1.0444405365124312 0.2962816171688289 1.0 0.7800982020530278 2 Q15436 1 +Polar cataract 0.780457890433363 1.0444405365124203 0.2962816171688338 1.0 0.7800982020530278 2 Q7LGA3 1 +Cutis laxa 0.407549848961391 1.0392479510815888 0.2986894347242286 1.0 0.781548598451925 22 Q15904,P41227 2 +Cone shaped epiphysis 0.5528247583473535 1.0392425644214658 0.2986919392986893 1.0 0.781548598451925 7 Q5JRA6 1 +Neoplasm of the genitourinary tract 0.3303048385990108 1.039236880724402 0.29869458199826 1.0 0.781548598451925 60 P48735,O75874,Q9UNW1,Q01844,Q9UPY3 5 +Aplasia hypoplasia involving the pelvis 0.4788435326482354 1.0386662603198709 0.2989599778956087 1.0 0.781548598451925 11 Q13363,O95831 2 +Upper limb spasticity 0.5704613144593913 1.0381912033801228 0.2991810471901939 1.0 0.781548598451925 6 Q99720,Q8N0X7,P35637 3 +Fatigable weakness of respiratory muscles 0.4668545489630754 1.031514026580961 0.3022998339747387 1.0 0.7859795683343206 13 Q14203,Q92804,Q9Y281,P35637 4 +Difficulty standing 0.7782652155814247 1.0257191906297602 0.3050239659400815 1.0 0.790736615516223 3 Q92734 1 +Hand muscle weakness 0.5253290541703239 1.0193733803439042 0.3080257388032854 1.0 0.792805768827569 8 Q9NR77,P11047 2 +Abnormal circulating ige level 0.656965316291761 1.016658405334521 0.3093159594248009 1.0 0.792805768827569 4 P40763,O95394 2 +Moderate albuminuria 0.7757663086626831 1.0165563660399188 0.3093645204539244 1.0 0.792805768827569 3 Q5JRA6 1 +Abnormal muscle fiber type distribution 0.4741362336393876 1.013947680891226 0.3106077178927042 1.0 0.792805768827569 11 O75340,P11047,P35609,Q9Y281 4 +Persistence of primary teeth 0.546814675029001 1.0121804568134982 0.311451778687525 1.0 0.792805768827569 7 P61586,P40763 2 +Hand polydactyly 0.3974365826312809 1.0108430914111484 0.312091535071882 1.0 0.792805768827569 24 Q13363,Q9BW83,Q9BXW9,Q9H3P2,Q92766 5 +Thick upper lip vermilion 0.5464351568463103 1.0104732378053656 0.3122686149557294 1.0 0.792805768827569 7 P41227,Q9UNW1 2 +Preaxial polydactyly 0.4682568078641242 1.009309372972654 0.3128262863683029 1.0 0.792805768827569 12 Q13363,Q9BXW9 2 +Abnormal uvula morphology 0.3681806319364729 1.0051572628179384 0.3148211303756447 1.0 0.792805768827569 35 P21281,P61978,Q15392,Q15813,Q9BXW9,Q9C0B1,P46777,Q15436,Q9NVI1,P36871 10 +Duodenal stenosis 0.7721707839345385 1.0033896911704718 0.3156728760458955 1.0 0.792805768827569 3 Q9BXW9 1 +Pyridoxine responsive sideroblastic anemia 0.7721707839345385 1.0033896911704718 0.3156728760458955 1.0 0.792805768827569 3 Q9BXW9 1 +Clubbing of toes 0.7721707839345385 1.0033896911704718 0.3156728760458955 1.0 0.792805768827569 3 Q9BXW9 1 +Joint hypermobility 0.312339755299777 1.0002969322067663 0.317166831394758 1.0 0.7942648128979208 70 P21281,O95394,Q9Y281,P55011,P26196,Q15436,Q03252,Q15904,O75648,Q8N0X7,P40763,Q08J23,Q15042,Q9Y296,Q92766,O15047,Q01105,Q06124 18 +Hyperthyroidism 0.520888957425137 0.9985610939329448 0.3180073551383104 1.0 0.7954683133623838 8 Q9BUK6,Q92766 2 +Epistaxis 0.4597939817693814 0.9928483883641092 0.3207838447808471 1.0 0.7984002610548931 13 P35579,P49257,Q6UN15,P10644,P40763,Q9Y3A5,P38435,O15460 8 +Organic aciduria 0.3693526529039146 0.9917701112151336 0.3213096809175142 1.0 0.7984002610548931 34 P48735 1 +Tapered finger 0.3760434233545721 0.9866977005982984 0.3237908576474821 1.0 0.8000676939459884 31 Q15555,Q9H9B1,Q9H4L7,P26196,Q03252,Q06136 6 +Multiple lipomas 0.7672801635991732 0.9855146548814622 0.3243713365500478 1.0 0.8000676939459884 3 Q9BUK6,Q9Y2U8 2 +Conical tooth 0.5401367797528891 0.9821731895639522 0.3260145333773638 1.0 0.802329753634715 7 P61586 1 +Tetraplegia 0.4675939044143906 0.9796647182738636 0.3272516472692153 1.0 0.8031384125096789 11 O95831,Q8NBF2 2 +Focal impaired awareness seizure 0.4296911428487622 0.9745508893892576 0.329783084416845 1.0 0.8066636597246569 17 P21281,Q14353,Q01105 3 +Limitation of joint mobility 0.3098750087336 0.9715027228873588 0.3312979978643353 1.0 0.8089426806030333 75 P48735,Q96J02,O75874,P11047,O14979,O60568,Q15042,Q96AX1,Q96AY3,O15460,Q06124 11 +Joint hemorrhage 0.7616516762060555 0.9701014371719608 0.3319959327180748 1.0 0.8089426806030333 2 P38435 1 +Menorrhagia 0.7616516762060537 0.9701014371719554 0.3319959327180775 1.0 0.8089426806030333 2 P35579 1 +Cessation of head growth 0.5874256349663864 0.9648075613460716 0.3346412079475636 1.0 0.811578752493525 5 Q9NR50 1 +Myositis 0.5128807277239337 0.9611116239150884 0.3364960457278254 1.0 0.8138389337830425 8 P28070 1 +Abnormality of the thyroid gland 0.3043352003097008 0.9544240963544992 0.3398690137980504 1.0 0.8144069491283559 88 Q9BUK6,Q5TBB1,P21281,P48735,Q15645,O75874,Q9UNW1,P57081,Q92766,P40763,Q9UPY3,P43246,Q9NVI1,Q96J02 14 +Oligodontia 0.4889580385089467 0.953899202928018 0.3401346669889016 1.0 0.8144069491283559 9 P21281,P61586,P61978 3 +Eversion of lateral third of lower eyelids 0.7555192150449745 0.9460401881072787 0.3441280887307394 1.0 0.8180780096185915 2 P61978 1 +Abnormal urine ph 0.3581838255167685 0.9459234940451384 0.3441876093909117 1.0 0.8180780096185915 36 P48735 1 +Abnormal peripheral nervous system physiology 0.3516659339295429 0.943430347518438 0.3454608266286312 1.0 0.8200651257883057 38 O95831,Q99720,Q9NR77,P04792 4 +Abnormal palmar dermatoglyphics 0.3397907389157811 0.9429891816445812 0.345686436494957 1.0 0.8200651257883057 44 Q13363,P21281,Q96AX1,Q9H9B1,Q9H4L7,P41227,P98175,O60568,Q9UQ13,Q96J02 10 +Aplasia of the uterus 0.5087714403607109 0.9419455502040318 0.346220517730667 1.0 0.8200651257883057 8 Q13363 1 +Anarthria 0.5267465088562522 0.9222483582509904 0.3563990441227944 1.0 0.8345238291781165 7 Q99720,P35637 2 +Abnormal upper motor neuron morphology 0.4823310910454744 0.9216785904543012 0.3566962512295442 1.0 0.8345238291781165 9 Q99720,P35637 2 +Abnormal atrioventricular conduction 0.4563487044428425 0.920981120015002 0.3570602841939472 1.0 0.8345238291781165 11 P0DP25,O43772 2 +Deep palmar crease 0.451201823502432 0.9183110994178014 0.3584560180025864 1.0 0.8356411390144683 12 P21281,Q96AX1,P98175,Q9UQ13 4 +Slender long bone 0.5237966089727367 0.9090989035137644 0.3632979213472729 1.0 0.8415482234258739 7 Q32P28,Q15813,Q4G0J3,P37268,Q96J02 5 +Abnormal circulating aspartate family amino acid concentration 0.5232227682105937 0.9065434065893248 0.3646483008558947 1.0 0.8438458061691385 7 P55263 1 +Multiple lentigines 0.5727610800486728 0.9039385151602956 0.3660280048706597 1.0 0.846239837252564 5 P10644,Q9UQ13,Q06124 3 +Eeg with multifocal slow activity 0.5726565697912409 0.9035063935358372 0.3662571965303518 1.0 0.846239837252564 5 Q05639,P61981,P38606,P49588 4 +Endocardial fibrosis 0.7440719542109602 0.901400772499724 0.3673752708309004 1.0 0.8470442315107843 2 P35609 1 +Melanocytic nevus 0.4999304430660444 0.9008468111459148 0.3676697745191273 1.0 0.8470442315107843 8 Q96AY3 1 +Neoplasm of the skin 0.3682854425867413 0.8967433298955052 0.3698558937299538 1.0 0.8489249536417326 29 Q06136,Q9H4L7 2 +Abnormality of dna repair 0.742457062697484 0.8954949284786018 0.370522575638271 1.0 0.8494345354362853 3 Q9BXW9 1 +Schistocytosis 0.7423151162762418 0.8949840195545149 0.3707956306084401 1.0 0.8496198482578047 3 P41440 1 +Recurrent bronchopulmonary infections 0.7412545160124728 0.8911681278067409 0.3728389803125709 1.0 0.8516528645899553 3 Q96AX1 1 +Diminished movement 0.4220026687717903 0.8824892792787755 0.3775122747234558 1.0 0.8572297509719975 16 O95831,Q6Y7W6,Q14203,Q9Y281 4 +Duodenal atresia 0.5166410805080963 0.877294060854459 0.3803269372957958 1.0 0.8573396809673764 7 Q15645,Q8N3U4,Q7LBC6,O43683,O43684 5 +Rib fusion 0.4940330386717437 0.8735502008738099 0.382363256195424 1.0 0.8573396809673764 8 Q13363 1 +Basal cell carcinoma 0.4722751076636332 0.8730233813431507 0.3826503335702651 1.0 0.8573396809673764 9 Q9UPY3 1 +Palpebral edema 0.5644699140401157 0.8697407968617719 0.3844420718066752 1.0 0.859501242987104 5 A6NHR9,Q01082,Q14331,Q12756 4 +Female infertility 0.7346688470973058 0.8650303605908434 0.3870221251581327 1.0 0.8617822635762965 2 Q15645 1 +Chronic sinusitis 0.7346688470973056 0.8650303605908426 0.3870221251581331 1.0 0.8617822635762965 2 O95394 1 +Anisocytosis 0.5626188595567554 0.86213049174602 0.3886157138185062 1.0 0.8637230309921011 5 P11413,Q8NBF2 2 +Albuminuria 0.6172591892396476 0.8610759669801981 0.3891962046799651 1.0 0.8637230309921011 4 Q5JRA6 1 +Regional abnormality of skin 0.2881342668717829 0.8588209143772626 0.3904393270211088 1.0 0.863959561795031 100 P41227,P00338,O75648,P98175,Q06136,Q9UQ13,Q96AY3,Q06124,Q13363,Q9H4L7,P26196,P20810,O60568,Q9Y296,P35609,Q9Y2U8,Q9H9B1,P55011,Q15042,P21281,P40763,Q96AX1,Q96J02 23 +Subvalvular aortic stenosis 0.5615965513734161 0.8579315148580826 0.3909302809603205 1.0 0.863959561795031 5 Q15645,O43683,Q06124 3 +Abnormal left ventricular outflow tract morphology 0.5615965513734161 0.8579315148580826 0.3909302809603205 1.0 0.863959561795031 5 Q15645,O43683,Q06124 3 +Aplasia hypoplasia of the radius 0.4295822215427048 0.8574501858908783 0.3911961337696477 1.0 0.863959561795031 14 Q15427,Q9BXW9,P98175,Q96AY3,Q9NVI1,P39019 6 +Aplasia hypoplasia involving forearm bones 0.4295822215427048 0.8574501858908783 0.3911961337696477 1.0 0.863959561795031 14 Q15427,Q9BXW9,P98175,Q96AY3,Q9NVI1,P39019 6 +Impaired vibration sensation in the lower limbs 0.456358296035068 0.8555149125282887 0.3922661523534754 1.0 0.8651778410191423 10 O00400 1 +Distal amyotrophy 0.3306115915237595 0.8538276281573444 0.3932005039037878 1.0 0.8652893879919594 43 Q9BUK6,Q99720,Q92734,P04792,P35637,Q14203,Q15813,O60568,Q9NR77 9 +Periorbital edema 0.3746196359402413 0.8501322522591814 0.3952515621198442 1.0 0.8663353272603973 24 P52565,Q9NQW6,Q8NFH4,P28070,Q9Y5K6 5 +Sclerocornea 0.5104595754919831 0.8499343348610819 0.3953615950965563 1.0 0.8663353272603973 7 Q13363 1 +Urethral stricture 0.7297628781684422 0.8461717968729942 0.397456912834955 1.0 0.8679642068826586 2 P09884 1 +Abnormal mitochondrial morphology 0.4661800438704399 0.8436963231805167 0.3988391226864052 1.0 0.8696935975697637 9 P22570,P51530,P35637 3 +Malignant hyperthermia 0.7259713701431484 0.8365019065913005 0.4028726046060837 1.0 0.8741761965433924 3 P36871,P50570 2 +Everted upper lip vermilion 0.6097986901551486 0.8322530397667808 0.4052661312290366 1.0 0.8766173829718908 4 O15047 1 +Abnormality of long bone morphology 0.2787122045125432 0.8315510199044377 0.4056624186842694 1.0 0.8766173829718908 132 P48735,O75874,O75648,P98175,Q08J23,Q96AY3,Q5JRA6,Q06124,Q13363,P26196,O60568,P38435,Q9Y296,O75718,Q9NR77,O95602,Q9Y2U8,Q9Y281,P55011,O95831,Q9H3U1,Q13126,P21281,Q15813,Q8WXI9,Q9BXW9,Q8N0X7,Q96AX1,O75312,Q9NVI1,Q96J02 31 +Aqueductal stenosis 0.5549299153705427 0.8306240180222443 0.4061860621271393 1.0 0.8766173829718908 5 Q15427,P57081 2 +Overgrowth 0.6091896506966028 0.8299071935377332 0.4065912574266097 1.0 0.8766173829718908 4 Q9UPY3,Q9H9B1 2 +Cerebral venous thrombosis 0.7224039247751495 0.8180469535047062 0.4133303769978527 1.0 0.8808916933733588 2 P36871 1 +Hyperphosphatemia 0.7224039247751473 0.8180469535046969 0.413330376997858 1.0 0.8808916933733588 2 Q15813 1 +Reduced natural killer cell count 0.7207650131675418 0.8180274962547105 0.413341486890576 1.0 0.8808916933733588 3 O95394 1 +Abnormal natural killer cell morphology 0.7207650131675418 0.8180274962547105 0.413341486890576 1.0 0.8808916933733588 3 O95394 1 +Abnormality of upper limb epiphysis morphology 0.4272700929674874 0.8167003226938958 0.4140997068749517 1.0 0.881948253158148 13 Q5JRA6 1 +Diaphragmatic eventration 0.7190184049079797 0.8118480226612471 0.4168788424321947 1.0 0.8840613373172566 3 P08243,O60568 2 +Reduced antigen specific t cell proliferation 0.7186094069529577 0.8104023531950859 0.4177089658400983 1.0 0.8840613373172566 3 O95394,P17812 2 +Abnormal t cell proliferation 0.7186094069529577 0.8104023531950859 0.4177089658400983 1.0 0.8840613373172566 3 O95394,P17812 2 +Chylothorax 0.7181988011044594 0.8089515237680992 0.4185430305050608 1.0 0.8840613373172566 3 Q06124 1 +Microdontia 0.3710122270243576 0.8068401720813956 0.4197585713097433 1.0 0.8840613373172566 23 P61586,Q15436,Q15555,P57081 4 +Morphological abnormality of the pyramidal tract 0.401496223220496 0.8059284048025098 0.4202841319640633 1.0 0.8840613373172566 17 P35637,Q13148,Q14203,O00400,O95831 5 +Abnormal odontoid tissue morphology 0.3525856175608386 0.8040168001869853 0.421387272506581 1.0 0.8840613373172566 31 P61586,Q96AY3 2 +Deep plantar creases 0.5483739475095624 0.8039055609831944 0.4214515182023102 1.0 0.8840613373172566 5 P21281 1 +Bifid uvula 0.3541310763896348 0.8021499092902991 0.4224662475790257 1.0 0.8840613373172566 30 P21281,P61978,Q15392,Q15813,Q9C0B1,P46777,Q15436,P36871 8 +Aplasia hypoplasia of the capital femoral epiphysis 0.7159638764721105 0.8010639623782686 0.4230946177300883 1.0 0.8840613373172566 3 O60568 1 +Abnormal parietal bone morphology 0.7154070354897903 0.7991012130310093 0.4242317263412654 1.0 0.8840613373172566 3 Q06124 1 +Abnormality of the sense of smell 0.4239578787405436 0.7990150531633209 0.4242816835190621 1.0 0.8840613373172566 13 Q9BW83,Q12824,Q04637,Q6Y7W6,Q06124 5 +Abnormality of adrenal morphology 0.3742246987295902 0.7981377618396664 0.4247905499745443 1.0 0.8840613373172566 21 P48735 1 +Xerostomia 0.4176793330057874 0.7922282889007365 0.4282275765728029 1.0 0.8840613373172566 14 P55011,P35637,Q13148,Q14203,Q92804 5 +Erythema 0.4225933647260594 0.791746785096046 0.4285083366950639 1.0 0.8840613373172566 13 Q06136 1 +Arrhinencephaly 0.4547622416092876 0.7891546779737826 0.4300216075972858 1.0 0.8840613373172566 9 Q92766,Q5TBB1 2 +Aplasia hypoplasia of the nipples 0.4266001443918837 0.7888515243946795 0.4301987909766565 1.0 0.8840613373172566 12 Q13363 1 +Large for gestational age 0.4958765055217653 0.7858904725465548 0.4319316566959752 1.0 0.8840613373172566 7 Q9UQ13,Q9H9B1 2 +Bloodstream infectious agent 0.7110258711668553 0.7836937366716218 0.4332198385539376 1.0 0.8840613373172566 3 P17812 1 +Chronic lung disease 0.4950463767115496 0.7822686834020655 0.4340566872636564 1.0 0.8840613373172566 7 Q9UNW1 1 +Abnormality of limb epiphysis morphology 0.3646149701276087 0.78066322229021 0.4350005968451333 1.0 0.8840613373172566 24 Q13363,O95831,Q5JRA6 3 +Abnormal synaptic transmission at the neuromuscular junction 0.3615191305982823 0.7784466183657268 0.4363057650055042 1.0 0.8840613373172566 25 O75340,Q92734,Q9Y281,P35637,P11047,Q9UNW1,Q92804 7 +Abnormal pericardium morphology 0.4732751439385032 0.7784186931306235 0.436322222166668 1.0 0.8840613373172566 8 O15460 1 +Dry skin 0.3637499029543528 0.7746947614127181 0.4385200472353108 1.0 0.8840613373172566 24 P52732,Q9H4L7,O75352,Q06136,P11802,Q5TBB1 6 +Low set posteriorly rotated ears 0.313544103771887 0.773524919604849 0.4392117867172982 1.0 0.8840613373172566 54 Q13363,Q15645,Q15555,P41227,Q15392,Q9BW83,Q15813,P98175,Q08J23,Q9H3P2,Q15042,Q96J02,Q06124 13 +Ventricular arrhythmia 0.3533175164160287 0.7733167052007021 0.4393349716948331 1.0 0.8840613373172566 28 P41227,P0DP25,O43772,P36871 4 +Adrenocortical abnormality 0.710139002452989 0.771645518810811 0.4403244067535823 1.0 0.8840613373172566 2 P10644 1 +Primary hypercortisolism 0.710139002452989 0.771645518810811 0.4403244067535823 1.0 0.8840613373172566 2 P10644 1 +Neoplasm by histology 0.2900767037984891 0.7704056810614996 0.4410592845236909 1.0 0.8840613373172566 87 P21281,Q8WX93,P48735,Q15645,Q15555,O75874,Q15392,Q01844,P46777,Q9UPY3,P43246,Q92804,Q13126,Q06124 14 +Thickened nuchal skin fold 0.5076767819388727 0.7680044372809045 0.4424845486990509 1.0 0.8840613373172566 6 P21281,Q06124 2 +Hypoplasia of teeth 0.4072794576331234 0.7646588563836502 0.4444747120042094 1.0 0.8841486170380763 15 P61586 1 +Abnormal dermatoglyphics 0.3125103087372169 0.763371344674317 0.4452419643944338 1.0 0.8848783644889379 54 Q13363,P21281,Q96AX1,Q9H9B1,Q9H4L7,P41227,P98175,O60568,Q15042,Q9UQ13,Q96J02,Q06124 12 +Abnormal facial expression 0.3562454461815458 0.7622518161497893 0.4459097257031041 1.0 0.8853226405358182 26 Q9BUK6,Q6Y7W6,Q14203,P51530,Q8WXI9,Q14331,Q04637,Q9NR77 8 +Biliary cirrhosis 0.4904147229701939 0.7621134274002387 0.445992309559895 1.0 0.8853226405358182 7 P14174,P48506 2 +Hypotelorism 0.3503283406879436 0.7615835154830677 0.4463086164439651 1.0 0.8853226405358182 29 Q9BUK6,O43776,P57081,Q15904,Q9BXW9,Q15042 6 +Primitive neuroectodermal tumor 0.4168603970578777 0.7613280444081146 0.4464611539317631 1.0 0.8853226405358182 13 Q9UPY3,P43246,Q06124 3 +Abnormal skin morphology of the palm 0.2907931872550169 0.7570547235983272 0.4490170778712619 1.0 0.8865785802114828 68 Q13363,P21281,Q96AX1,Q9Y2U8,Q9H9B1,Q9H4L7,P41227,P20810,P98175,O60568,Q06136,Q9UQ13,P35609,Q96J02 14 +Profound global developmental delay 0.4667296623728742 0.7487920529491311 0.4539825503727583 1.0 0.8902408485570507 8 P83436,P55011,P57081 3 +Arm dystonia 0.7004673774242898 0.7468325857676588 0.4551646232044781 1.0 0.8905549170041571 3 Q99720 1 +Ambiguous genitalia 0.3840654689612994 0.7467224407097247 0.4552311209819444 1.0 0.8905549170041571 18 Q15392,P22570,Q15645,Q9UNW1 4 +Abnormality of the breast 0.2905674617400927 0.7462188208011303 0.4555352406519648 1.0 0.8905549170041571 77 Q13363,Q8WX93,P48735,O75874,Q9H3P2,P83436,P43246,Q06124 8 +Finger syndactyly 0.3567551030785822 0.7450940578196257 0.4562148610951471 1.0 0.8906668224560734 25 Q9Y2U8,P41227,Q9BW83,Q9BXW9,P98175,Q9NVI1 6 +Polysplenia 0.702780049059694 0.7441152891662755 0.4568067304198029 1.0 0.8906998191797961 2 Q86Y56 1 +Broad distal phalanx of finger 0.5332267105008843 0.7427635471865995 0.4576248487008501 1.0 0.8906998191797961 5 Q8WXI9 1 +Abnormal urine phosphate concentration 0.7019623875715515 0.7410717255864541 0.4586499521387353 1.0 0.8906998191797961 2 O14745 1 +Hyperphosphaturia 0.7019623875715515 0.7410717255864541 0.4586499521387353 1.0 0.8906998191797961 2 O14745 1 +Hyperparathyroidism 0.7019623875715504 0.7410717255864518 0.4586499521387366 1.0 0.8906998191797961 2 P53680 1 +Elevated circulating parathyroid hormone level 0.7019623875715503 0.7410717255864518 0.4586499521387366 1.0 0.8906998191797961 2 P10644 1 +Primary hyperparathyroidism 0.7019623875715504 0.7410717255864518 0.4586499521387366 1.0 0.8906998191797961 2 P53680 1 +Supraventricular arrhythmia 0.4320958065534054 0.7361045556445907 0.461667070555134 1.0 0.8918568408451452 10 P41227,P35609,P07741 3 +Severe lactic acidosis 0.6968789558203219 0.7343973495218524 0.4627066017089918 1.0 0.891915909094524 3 Q70HW3 1 +Leukocytosis 0.3656735965958299 0.7307821427487162 0.464912232585136 1.0 0.8943765704672493 20 P11413,Q03252,O15143,P40763,O75312,Q5TBB1 6 +Fatigable weakness of swallowing muscles 0.4153401308891891 0.7306261743415232 0.4650075200083969 1.0 0.8943765704672493 12 Q14203,Q92804,P35637 3 +Aganglionic megacolon 0.406176867077191 0.729996274757177 0.4653924616775224 1.0 0.8943765704672493 14 Q9BXW9,Q92766,P41227,Q9NVI1 4 +Sagittal craniosynostosis 0.5824993793328528 0.7283304756307449 0.4664113110694592 1.0 0.8943765704672493 4 P21281,P61978 2 +Absent septum pellucidum 0.350968512624364 0.724764696531593 0.4685963972527771 1.0 0.8969889099589061 26 Q13363,P15311,Q13409,Q9H9B1,P55011,Q15392,Q08J23,Q9ULK4,Q9NVI1 9 +Focal dystonia 0.3999971217322586 0.7244519409924477 0.4687883217206048 1.0 0.8969889099589061 15 Q99720,P35637 2 +Abnormal prolactin level 0.6936859676020778 0.723374079493617 0.4694500915889374 1.0 0.8978664668209015 3 Q12824 1 +Kyphoscoliosis 0.3197157549526835 0.7212854550943127 0.4707339039793385 1.0 0.8995433876302102 40 Q9NR77,P51530,P41227,Q15042,Q96AY3,O15347 6 +Multiple joint contractures 0.393747783699091 0.7206876647360012 0.4711017034788907 1.0 0.8997482297175909 16 P51530,Q5TBB1,P41440 3 +Shuffling gait 0.4288638599122564 0.7204349663303402 0.4712572276322322 1.0 0.8997482297175909 10 Q14203,P41227,Q6Y7W6 3 +Fatigable weakness of bulbar muscles 0.4084387125187358 0.7170253035754119 0.4733584837081113 1.0 0.9008519424302972 13 Q14203,Q92804,P35637 3 +Abnormality of globe size 0.3136332962012426 0.7158754811932371 0.4740682393875275 1.0 0.9008519424302972 47 Q9BUK6,P52732,Q15645,Q15555,P41227,O60828,Q9BXW9,Q15042,P61586,Q92766,O15347 11 +Lower limb muscle weakness 0.3455138524528578 0.707790987187232 0.4790750641493728 1.0 0.901134191120362 27 O00400,Q9NR77,P04792 3 +Supraventricular tachycardia 0.6865742653607785 0.6989692073555591 0.4845712747495594 1.0 0.9037152043852544 3 P41227 1 +Decreased proportion of cd3 positive t cells 0.6901062959934641 0.6973073102684003 0.4856104941424748 1.0 0.9041694404932848 2 O95394 1 +Protrusio acetabuli 0.6832631135394849 0.6876786915106411 0.4916551414815258 1.0 0.9100149603636282 3 Q96AY3 1 +Abnormal circulating protein concentration 0.2622159739703207 0.6872900260559903 0.4918999827782289 1.0 0.910087033855074 118 Q92734,O43772,P51530,P00338,O75648,Q08J23,P36871,O75340,Q8N511,Q9BUK6,P14174,O14979,P57081,O00400,Q9NQW6,P35609,Q9Y281,P41440,Q9BTW9,P52565,O95831,Q14331,P83436,Q9Y5K6,P43897,P11047,Q8NFH4,Q96AX1 28 +Abnormality of the periorbital region 0.297990488000551 0.6840553225661907 0.4939402324225139 1.0 0.9119531442387268 59 P52732,Q15436,P52565,P57081,Q9NQW6,Q8WXI9,Q8NFH4,P98175,P28070,Q96AX1,O14646,Q9Y5K6 12 +Thoracolumbar scoliosis 0.4873105159805402 0.6831872297508562 0.49448854101042 1.0 0.912584280278103 6 P21281,Q93008 2 +Downturned corners of mouth 0.3329351336740881 0.6821052196566743 0.4951724203348644 1.0 0.9128116690629292 33 Q13363,P21281,Q9Y2U8,Q9H9B1,P57081,O60568,Q9H3P2,P40763 8 +Metaphyseal dysplasia 0.4517652725836468 0.6818904303332187 0.4953082369810766 1.0 0.9128116690629292 8 O95831,Q7Z2Z2,Q07864 3 +Abnormality of cranial sutures 0.2893928457591216 0.680078249757356 0.4964549155889344 1.0 0.9131806062162788 64 P21281,Q9Y2U8,P61978,P26196,P41227,Q15813,Q15436,O95831,P09884,P98175,Q08J23,P40763,O75718,Q96AY3,Q92766,O15047 16 +Localized skin lesion 0.2812641497956801 0.6786411502588683 0.4973652626605034 1.0 0.9136967834411576 168 Q13363,P48735,P34913,Q9H4L7,O75874,Q06136,P61586,Q96AY3,O15460 9 +Abnormality of the nasal septum 0.5168795672742705 0.6778721406765612 0.4978527654564297 1.0 0.9138783539458812 5 P21281,P22314 2 +Motor neuron atrophy 0.3572986517543896 0.6775342832749928 0.4980670257799198 1.0 0.9138783539458812 20 Q99720,Q92734,P35637,Q14203,Q92804,Q16637 6 +Bifid tongue 0.6797546012269876 0.6757673717127906 0.4991883536126924 1.0 0.9149189678362708 3 Q6DKJ4,P61978 2 +Abnormal vertebral morphology 0.2817805455708136 0.6746573169446013 0.4998935084444782 1.0 0.9149189678362708 88 Q13363,P48735,O75874,O95831,Q96AY3,Q15436,Q5JRA6 7 +Muscle spasm 0.3091225111862881 0.6697896622202223 0.5029918845622015 1.0 0.9181082573616036 46 O75340,Q92734,Q6Y7W6,P04792,P35637,Q14203,P51530,Q9NR77,Q92804,Q16637 10 +Hypoplasia of the frontal lobes 0.4830839280693831 0.6658444452130378 0.5055105330426763 1.0 0.919111676400774 6 P22570 1 +Recurrent viral infections 0.4173191217485928 0.6650216489267782 0.5060366464042412 1.0 0.9194779283141956 10 Q7Z2Z2,O95394,P33991,Q9Y3A5,P17812 5 +Abnormality of vitamin b12 metabolism 0.4165921953003041 0.66156411878061 0.5082506094591053 1.0 0.920332298336768 10 P41440 1 +Broad alveolar ridges 0.6794766966475934 0.6586971118573478 0.5100902879831843 1.0 0.920332298336768 2 P21281 1 +Abnormal blood phosphate concentration 0.4811349063638739 0.6578806604361355 0.5106148186616861 1.0 0.920332298336768 6 P10644,P53680,Q15813,O14745 4 +Decreased lacrimation 0.5112449180141574 0.6558112480957301 0.5119455782730151 1.0 0.920332298336768 5 O95163,P55011 2 +Morphological abnormality of the corticospinal tract 0.3962822568144621 0.6540082217018667 0.5131065086961648 1.0 0.920332298336768 13 O00400,Q14203,P35637 3 +Lymphoproliferative disorder 0.6732106339468353 0.6536998649043507 0.5133051903145942 1.0 0.920332298336768 3 P33991,P17812 2 +Hyposmia 0.3995048198822467 0.6502214918586372 0.5155491604149232 1.0 0.920332298336768 12 Q04637,Q6Y7W6,Q9BW83,Q06124 4 +Abnormally lax or hyperextensible skin 0.3285225382778278 0.6481733236689166 0.5168728536522393 1.0 0.920332298336768 33 Q15555,P41227,Q15904,P38435,Q06124 5 +Facial asymmetry 0.3357772776621361 0.6458002664445138 0.5184087154363892 1.0 0.920332298336768 28 Q13363,P61586,Q01105 3 +Abnormality of the 1st metacarpal 0.4435602018352254 0.6457738720505418 0.5184258113560036 1.0 0.920332298336768 8 Q9BXW9,O60828 2 +Abnormality of the palm 0.2813226981169134 0.6431296937830657 0.5201399483952964 1.0 0.920332298336768 80 Q13363,P21281,Q9Y2U8,Q15555,Q9H4L7,Q9H9B1,Q9UQ13,P41227,P20810,Q15813,O95831,O60568,P98175,Q06136,Q96AX1,P35609,Q96J02 17 +Capillary hemangioma 0.4774818164048836 0.6430133766307475 0.5202154201653204 1.0 0.920332298336768 6 P21281,Q15436 2 +Minicore myopathy 0.6699386503067479 0.6427417369768329 0.5203916941040796 1.0 0.920332298336768 3 Q15650,Q9Y281 2 +Paralysis 0.3189317065773416 0.6426955201336243 0.5204216884631447 1.0 0.920332298336768 37 Q9NR77,P04792,P35637 3 +Abnormal circulating dicarboxylic acid concentration 0.3230851503208928 0.6379690635096894 0.5234938185791609 1.0 0.920332298336768 35 P48735,P41440 2 +Abnormal elasticity of skin 0.3023032067919435 0.6373623140189317 0.5238888699772777 1.0 0.920332298336768 51 Q15555,Q9H4L7,Q9H9B1,P41227,Q15904,P38435,Q13126,Q06124 8 +Abnormal b cell subset distribution 0.6729354047424427 0.635257393950982 0.5252605563560795 1.0 0.920332298336768 2 P17812 1 +Decreased specific antibody response to vaccination 0.6729354047424427 0.635257393950982 0.5252605563560795 1.0 0.920332298336768 2 P17812 1 +Recurrent sinusitis 0.6729354047424423 0.6352573939509814 0.5252605563560799 1.0 0.920332298336768 2 Q86Y56 1 +Preauricular skin tag 0.383551442632203 0.6352513389213411 0.5252645048091109 1.0 0.920332298336768 15 Q13363 1 +Duplication of hand bones 0.3052394897503017 0.6348266783198688 0.5255414616366418 1.0 0.920332298336768 46 Q13363,Q9Y2U8,P41227,Q9BW83,Q9BXW9,Q9H3P2,P46777,Q92766 8 +Gaze evoked nystagmus 0.4215797048455235 0.634581703034385 0.5257012645510335 1.0 0.920332298336768 9 P41440 1 +Protruding tongue 0.4207447623271338 0.6307870835224414 0.5281797499868819 1.0 0.922384233481635 9 P83436,Q9C0B1 2 +Autoimmune antibody positivity 0.4397628831128172 0.6292121520431989 0.529210174217581 1.0 0.9227289507215872 8 Q96J02 1 +Oral ulcer 0.5039171320097661 0.6273843042815876 0.5304073537725931 1.0 0.9227289507215872 5 Q7Z2Z2 1 +Brachydactyly 0.2983386509926153 0.62640743769711 0.5310477323272154 1.0 0.9227289507215872 54 P21281,Q9H9B1,O95831,Q8N0X7,Q08J23,Q06136,Q9C0B1,Q9UQ13,P61586,Q06124 10 +Juvenile myelomonocytic leukemia 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Amegakaryocytic thrombocytopenia 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Reduced factor xii activity 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Reduced factor xiii activity 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Myeloid leukemia 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Pectus excavatum of inferior sternum 0.670073589533939 0.6250836922692159 0.5319161304617939 1.0 0.9227289507215872 2 Q06124 1 +Keratosis pilaris 0.6700735895339389 0.6250836922692141 0.531916130461795 1.0 0.9227289507215872 2 Q9UQ13 1 +Fetal ultrasound soft marker 0.4385820204961608 0.6240828031654255 0.5325732069899987 1.0 0.9227289507215872 8 P21281,P26196,Q06124 3 +Atrioventricular canal defect 0.4726721862009899 0.6235624061290553 0.5329150061698373 1.0 0.9227289507215872 6 Q9UBM7,P17612,Q06124 3 +Calvarial skull defect 0.4382963380154724 0.6228433981407775 0.5333874364465283 1.0 0.9227289507215872 8 Q13363 1 +Autoimmune thrombocytopenia 0.4713801550839008 0.6183620021662068 0.53633673946199 1.0 0.923134107640964 6 P40763,P00491 2 +Acute kidney injury 0.552094008507245 0.61628910499269 0.5377037282372386 1.0 0.924427255949674 4 P00338 1 +Skin tags 0.3745235954248917 0.6141809551981858 0.5390957568951869 1.0 0.9260797689377092 16 Q13363 1 +Convex nasal ridge 0.367824447426104 0.6116268679944507 0.5407846574808937 1.0 0.927530673796088 17 Q13363,Q15813,P51530,Q96J02 4 +Adult onset 0.3010809502053604 0.6068147513217047 0.5439738574347341 1.0 0.9277800541970366 48 Q92734,P17096,P04792,P41440,Q16637 5 +Neoplasm of fatty tissue 0.4680954787331196 0.6051902553016657 0.5450525898766201 1.0 0.9277800541970366 6 Q9BUK6,P53680,Q9Y2U8 3 +Head tremor 0.3935616728816545 0.6040767392230827 0.5457926235634061 1.0 0.9277800541970366 11 Q99720 1 +Periorbital fullness 0.3596009335136809 0.6024054233097714 0.5469043008684873 1.0 0.9277800541970366 18 Q7LGA3,P38159,P57081,Q8WXI9,Q96AX1,O14646 6 +Decreased facial expression 0.3451189240852021 0.6015365778929842 0.5474826567016948 1.0 0.9277800541970366 20 Q04637,Q14203,P51530,Q6Y7W6 4 +Thyroid carcinoma 0.3817836436920752 0.6014716533839478 0.5475258865090411 1.0 0.9277800541970366 14 Q9UPY3 1 +Wide nose 0.3256011844555432 0.6006446614905955 0.5480766844713536 1.0 0.9277800541970366 31 P21281,P52732,Q9Y2U8,Q15645,P40763,Q96AX1,P83436,Q15436,O15047 9 +Decreased circulating antibody level 0.3220739970589092 0.5991628586019738 0.549064287793688 1.0 0.9277800541970366 33 P14174,Q15904,P40763,Q96AX1,Q96J02 5 +Pulmonary cyst 0.5464208436282709 0.595922942717553 0.5512267056529607 1.0 0.9277800541970366 4 P10644,Q86TI2 2 +J shaped sella turcica 0.5455884733128935 0.5929508569605456 0.5532140411132263 1.0 0.9277800541970366 4 O60568 1 +Deformed sella turcica 0.5455884733128935 0.5929508569605456 0.5532140411132263 1.0 0.9277800541970366 4 O60568 1 +Megalocornea 0.4015504453433301 0.5909786241410805 0.5545347435272079 1.0 0.9277800541970366 10 Q13363,Q9H3P2 2 +Anisocoria 0.5445810652741614 0.5893594004691125 0.5556202054852579 1.0 0.9277800541970366 4 Q9NR77 1 +Low hanging columella 0.4298921775564033 0.5866593933712938 0.5574324847675107 1.0 0.9277800541970366 8 Q9BTW9,O60828,Q96J02 3 +Postaxial polydactyly 0.3823229069939229 0.5832772654398971 0.559706664516584 1.0 0.9277800541970366 13 Q2VPK5,P17612,P61978,Q9BW83,Q9UBM7,P98175,P30153 7 +Akinesia 0.4091379146338998 0.5786278428493108 0.5628403135578275 1.0 0.9281449676333277 9 Q14203,Q6Y7W6 2 +Chronic constipation 0.3322405485177818 0.5776897070794651 0.5634736295662006 1.0 0.9281449676333277 25 P55011,Q9BTW9,Q03252,Q8WXI9,Q04637,Q6Y7W6,O15047 7 +Cupped ear 0.3982609605619001 0.5758080392201363 0.5647449390518544 1.0 0.9281449676333277 10 Q15392 1 +Plantar hyperkeratosis 0.3315101934928772 0.5728350342333698 0.5667563953941972 1.0 0.9281449676333277 25 Q06136 1 +Decreased pulmonary function 0.653720359771061 0.5679645923639396 0.5700590107048125 1.0 0.9318272290367126 2 Q12824 1 +Abnormality of skull ossification 0.3855346897201729 0.5656618581609691 0.5716236684110685 1.0 0.9320002964183244 11 O75718,Q15436 2 +Decreased number of peripheral myelinated nerve fibers 0.3957609055613669 0.5643479819994859 0.5725173327703983 1.0 0.9320002964183244 10 Q9NR77 1 +Holoprosencephaly 0.3951982137029264 0.5617771830990673 0.574267839717681 1.0 0.9320002964183244 10 Q15645,Q8N3U4,Q9UBM7,P06400,O43683,O43684 6 +Generalized osteosclerosis 0.6449034343062656 0.5607348426727985 0.5749783108623312 1.0 0.9320002964183244 3 Q15392 1 +Oculomotor nerve palsy 0.644664297955351 0.5599684097118135 0.5755009853581403 1.0 0.9320002964183244 3 Q12824 1 +Cardiac diverticulum 0.5357523088131879 0.5581568246175639 0.5767373004473766 1.0 0.9320002964183244 4 P43246 1 +Synovitis 0.6436446864447739 0.5567043835179525 0.5777294214561093 1.0 0.9320002964183244 3 Q06124 1 +Delayed cns myelination 0.326303706268519 0.5542817591704833 0.5793860318705595 1.0 0.9320002964183244 26 O43776,O95831,Q15042,Q96AX1,O15047,Q9Y3C6 6 +Abnormal shape of the occiput 0.3619803718742921 0.5468667920520833 0.5844702516169575 1.0 0.9359994609228088 16 P52732,Q9Y2U8,Q9H9B1,Q96J02 4 +Abnormality of corneal size 0.3215243823593839 0.5454618584552173 0.5854359061781873 1.0 0.9365279425651784 28 Q13363,Q15555,P41227,Q9H3P2,Q15042,O15347 6 +Short chin 0.4000456221181558 0.5386128747427039 0.5901540020056564 1.0 0.939654426824568 9 Q96J02 1 +Decreased circulating acth level 0.6373023347651672 0.5365430377741267 0.5915832998931627 1.0 0.9409133449182364 3 Q12824 1 +Fatigable weakness of skeletal muscles 0.4347710877870277 0.5293097139393544 0.5965906181020919 1.0 0.941700315211874 7 Q92734,Q9UNW1 2 +Anal atresia 0.3397626270374811 0.5269636867032824 0.5982188059630369 1.0 0.942989510151137 19 Q9H9B1,P41227,O60828,Q9BXW9,Q92766 5 +Abnormality of the spinal cord 0.2859891311991724 0.5203233701237071 0.6028382099123228 1.0 0.946552358015086 55 Q13363,P21281,Q9Y2U8,Q99707,P51530,P48506,Q9UNW1,O00400,Q9BXW9,Q08J23,Q9H3P2,Q92766,Q9NVI1,Q06124 14 +Pain 0.2609046346650912 0.5199104020366264 0.6031260249874255 1.0 0.9466679795612292 140 P48735,O75874,Q14203,P51530,P43246,O15460,Q06124,Q9BUK6,Q8WX93,P14174,Q15645,Q9NQW6,P28070,Q9NR77,Q9Y2U8,Q9UNW1,P52565,Q9H3U1,Q92766,Q9Y5K6,Q70HW3,P11413,P35637,Q03252,Q8NFH4,P40763,Q01844,Q92804 28 +Abnormality of primary teeth 0.369048425638343 0.5179739671224926 0.6044764328227636 1.0 0.9481142062017798 13 P61586,P40763,Q9H9B1 3 +Abnormality of female external genitalia 0.3228242281034806 0.5158232568570498 0.6059778576801889 1.0 0.94965072765059 25 P22570,Q15392,Q9UNW1 3 +Abnormality of the clitoris 0.3719198980173305 0.5156475242609009 0.6061006114711118 1.0 0.94965072765059 12 P22570,Q9UNW1 2 +Abnormal circulating albumin concentration 0.3200382834574943 0.5125558116409694 0.6082620700788395 1.0 0.9509041211036794 26 P52565,P57081,Q9NQW6,Q8NFH4,Q96AX1 5 +Abnormality of lower limb epiphysis morphology 0.3712094245995478 0.5122940443768128 0.6084452327728274 1.0 0.9509041211036794 12 O95831,Q7LGA3,O60568,Q9H3U1 4 +Abnormal metatarsal morphology 0.3436231106599022 0.5120887654555942 0.6085888868652849 1.0 0.9509041211036794 18 Q13363 1 +Increased circulating igm level 0.4438142596655473 0.5102544112774722 0.6098732369508859 1.0 0.9519219655843124 6 Q96AX1,O95394 2 +Abnormal sputum 0.5213636600235603 0.5084313247719118 0.611150889455135 1.0 0.9529871733352812 4 Q86Y56,P49327 2 +Hypotension 0.3429362142205567 0.508292027545361 0.6112485602727427 1.0 0.9529871733352812 18 Q14203,Q6Y7W6,O43772 3 +Muscle hypertrophy of the lower extremities 0.4283489851187416 0.5038999703498773 0.6143316714084526 1.0 0.9557146828033424 7 Q9NR77,Q14331 2 +Abnormality of vitamin metabolism 0.3261168125107739 0.5020540724067997 0.6156294855872415 1.0 0.9561076339759688 22 Q9UDY2,P41440 2 +Erythroderma 0.4404897814967977 0.4976281777152592 0.6187461393306797 1.0 0.9586789275798384 6 P26639,O75352 2 +Coloboma 0.3082156136383484 0.4965990821969904 0.6194718004959827 1.0 0.9586789275798384 33 O75340,Q13363,P41227,O60828,Q15042,O15347 6 +Patchy changes of bone mineral density 0.5168019257774706 0.4929821909553257 0.6220251709486058 1.0 0.9603043156104916 4 Q13126 1 +Limb muscle weakness 0.2807802701578331 0.4920062606671449 0.6227149176935367 1.0 0.9608014472755172 57 Q99720,Q92734,P04792,Q9Y281,Q14203,Q15813,P07384,O00400,Q9NR77,Q16637,Q13126 11 +Pancreatic hypoplasia 0.4668968443519098 0.4892226347879642 0.624684086415235 1.0 0.9608014472755172 5 Q7Z2Z2,P40763 2 +Single transverse palmar crease 0.3104662790370758 0.4833865237405771 0.6288213150441473 1.0 0.9608014472755172 30 Q13363,Q9H4L7 2 +Abnormal eosinophil morphology 0.4366687187312681 0.4832386686985817 0.6289262819860582 1.0 0.9608014472755172 6 P40763 1 +Ectopic kidney 0.3648230634999321 0.4824431209347574 0.6294911950503366 1.0 0.9608014472755172 12 P51530,Q9BXW9,Q9Y2U8 3 +Centrally nucleated skeletal muscle fibers 0.4364381847639101 0.4823748133900805 0.6295397098871904 1.0 0.9608014472755172 6 Q15650,P22626,P50570 3 +Butterfly vertebrae 0.6275551921504567 0.480615848048925 0.6307895497500762 1.0 0.9608014472755172 2 Q8N3U4 1 +Sparse lateral eyebrow 0.4352485857750563 0.4779250606218233 0.6327035438403206 1.0 0.9608014472755172 6 Q08J23,O60828 2 +Hypoamylasemia 0.5121769972135631 0.4774845070473532 0.633017150577249 1.0 0.9608014472755172 4 Q7Z2Z2,Q9Y3A5 2 +Abnormality of refraction 0.2484013322028514 0.4750547298169039 0.6347479643051619 1.0 0.9608014472755172 111 Q7LGA3,O60828,Q15904,O75648,P98175,Q08J23,Q12824,Q9UQ13,P61586,O15460,Q06124,Q15555,P26196,O60568,Q9Y296,P52732,Q9H9B1,P55011,P61978,P21281,P26639,Q9NWX6,Q15813,P11047,Q8WXI9,Q9BXW9,Q9NVI1 27 +Arthrogryposis multiplex congenita 0.3111774719588016 0.4750436417596499 0.6347558672969009 1.0 0.9608014472755172 28 Q96AY3,Q15392,Q9Y281 3 +Craniosynostosis 0.311076039199499 0.4743649739784086 0.6352396656885877 1.0 0.9608014472755172 28 P21281,P26639,Q9Y2U8,P61978,Q92785,P40763,Q08J23,P09884,Q92766,O15047 10 +Areflexia 0.2737675895141325 0.4736362378137951 0.6357593295048938 1.0 0.9608014472755172 61 O75340,Q92734,P04792,Q9Y281,P41440,O95831,Q9NR77,Q16637 8 +Complete atrioventricular canal defect 0.6251022076860253 0.4727104188150388 0.6364197923503008 1.0 0.9608014472755172 2 P17612 1 +Abnormality of neutrophil physiology 0.5097220053968691 0.4693278791133388 0.6388352905879771 1.0 0.9615408829938292 4 Q7Z2Z2,Q9Y3A5 2 +Absent forearm bone 0.5095924875089728 0.4688989301672169 0.6391418810488394 1.0 0.9615408829938292 4 Q9BXW9 1 +Fused cervical vertebrae 0.4325722968508829 0.4679633046761722 0.6398108315332158 1.0 0.9622197602507024 6 Q9Y2W2,Q9NVI1,O75369,Q9UHX1 4 +Aplasia cutis congenita 0.3738767371757788 0.4669199221850581 0.6405571712573037 1.0 0.9626654365481212 10 Q13363,Q9H3P2 2 +Abnormality of the intrinsic pathway 0.3735524500788609 0.4655190889707903 0.6415597701107931 1.0 0.9631281058716276 10 P38435,P36871 2 +Emg decremental response of compound muscle action potential to repetitive nerve stimulation 0.6141822328568491 0.4652775502993532 0.6417327093713736 1.0 0.9631281058716276 3 O75340 1 +Response to drugs acting on neuromuscular transmission 0.6141822328568491 0.4652775502993532 0.6417327093713736 1.0 0.9631281058716276 3 O75340 1 +Acanthocytosis 0.6222403924775217 0.4635532398003159 0.6429678625337203 1.0 0.9632071275248484 2 Q05682 1 +Anisopoikilocytosis 0.6222403924775217 0.4635532398003159 0.6429678625337203 1.0 0.9632071275248484 2 Q05682 1 +Abnormality of the calf musculature 0.3730597598892726 0.4633934039866237 0.6430824057298252 1.0 0.9632071275248484 10 Q9NR77,Q14331 2 +Chronic otitis media 0.321709462024329 0.4617057448001649 0.6442923508117231 1.0 0.9643657943067444 20 Q13363,Q92766,Q9H3P2,P40763 4 +Schwannoma 0.611556800902676 0.4574228218010662 0.6473671638517939 1.0 0.9665642078617938 3 Q12824 1 +Syndactyly 0.2655161995861166 0.4529380587326262 0.6505933446845034 1.0 0.9678400194534532 65 P21281,O43776,Q9Y2U8,Q9H4L7,P26196,P41227,Q9BW83,Q96EK5,Q9BXW9,P98175,Q08J23,P61586,Q9NVI1 13 +Selective tooth agenesis 0.4562941356762788 0.451659393173219 0.6515143757867832 1.0 0.9678400194534532 5 P41227 1 +Duplicated collecting system 0.4277160479709996 0.4500653298004795 0.6526633349592419 1.0 0.9678400194534532 6 Q9BXW9 1 +Abnormal lung lobation 0.3576621105653547 0.449635512984786 0.6529732769174326 1.0 0.9678400194534532 12 Q15645,Q9UBM7,Q92766,O43683,O43684 5 +Abnormal size of the clitoris 0.3695400665946245 0.4483006797653632 0.6539362101205404 1.0 0.9683075540143344 10 Q9UNW1 1 +Disturbance of facial expression 0.4254244395480847 0.4417016290953877 0.6587051306694616 1.0 0.971130795145866 6 Q8WXI9,Q9NR77 2 +Abnormality of humoral immunity 0.2835191022170226 0.4414063638994016 0.6589188358919575 1.0 0.971130795145866 43 P14174,Q03252,Q15904,P40763,P28070,Q96AX1,Q96J02 7 +Abnormality of the endometrium 0.4528782437270163 0.4397785943735215 0.6600974725320383 1.0 0.9716069462507544 5 P43246,P52701 2 +Decreased proportion of cd4 positive helper t cells 0.6043020303405059 0.4359888016252722 0.6628448544570265 1.0 0.97431801020953 3 O95394 1 +Abnormality of dental eruption 0.2815015707848302 0.4325611873393902 0.6653335914260707 1.0 0.976352747046226 47 P21281,Q9H9B1,P41227,P40763,Q08J23,P61586,Q15436,Q5JRA6 8 +Aplasia hypoplasia of the ulna 0.3914113793349094 0.4292305312819152 0.6677554662213154 1.0 0.9774436638901376 8 Q9BXW9,Q9NVI1,Q15427 3 +Difficulty walking 0.2813265308909446 0.4283298616988044 0.6684109810069769 1.0 0.9774436638901376 46 Q9BUK6,O75340,Q99720,P04792,P35637,P51530,P07384,Q8N0X7,Q12824,Q9NR77,P23381,Q5TBB1 12 +Reduction of neutrophil motility 0.601629079588478 0.4281944638103958 0.6685095465927344 1.0 0.9774436638901376 3 Q7Z2Z2 1 +Abnormality of vitamin e metabolism 0.601629079588478 0.4281944638103958 0.6685095465927344 1.0 0.9774436638901376 3 Q7Z2Z2 1 +Deformed rib cage 0.601629079588478 0.4281944638103958 0.6685095465927344 1.0 0.9774436638901376 3 Q7Z2Z2 1 +Proximal femoral epiphysiolysis 0.601629079588478 0.4281944638103958 0.6685095465927344 1.0 0.9774436638901376 3 Q7Z2Z2 1 +Full cheeks 0.3039376810149274 0.4272299753717932 0.6692118303883796 1.0 0.9778235670468224 28 P52732,Q15813,Q00535,Q96AX1,O15047 5 +Hypoplasia of the radius 0.4079438650717052 0.4258402963036795 0.67022422183872 1.0 0.978332582736837 7 P98175,Q9NVI1,Q15427,P39019 4 +Abnormality of the extrinsic pathway 0.448448382499372 0.4245399019687125 0.6711721115066818 1.0 0.9787465301417134 5 P36871 1 +Autoimmunity 0.3040089788163215 0.4235763636010092 0.6718747961990048 1.0 0.9791764795640888 27 P14174,Q03252,P40763,Q96J02,Q92766,Q5TBB1 6 +Muscle fiber inclusion bodies 0.4064022135299975 0.4201236852269137 0.6743951008504725 1.0 0.9803827142758864 7 O75340 1 +Low posterior hairline 0.3074309169347298 0.4185657099199069 0.6755335542502894 1.0 0.9803827142758864 25 Q13363,Q96AX1,Q9H3P2,Q15042 4 +Abnormal neuron morphology 0.3083851586590073 0.4136413728866831 0.6791367688318495 1.0 0.9816169124384484 24 Q92804,Q99720,Q92734,P35637 4 +Prolonged neonatal jaundice 0.3494513953869956 0.4129563059579803 0.6796386268289791 1.0 0.9820211607009114 12 Q15904,Q9H3U1,Q5TBB1 3 +Abnormality of the nasolabial region 0.5959100204499015 0.4117095013210979 0.6805523600506116 1.0 0.9820379838440648 3 Q9Y487,Q93008 2 +Prominent nasolabial fold 0.5959100204499013 0.4117095013210964 0.6805523600506127 1.0 0.9820379838440648 3 Q9Y487,Q93008 2 +Pierre robin sequence 0.4170745908076949 0.4116935372547841 0.6805640625204636 1.0 0.9820379838440648 6 P36871 1 +Brain neoplasm 0.5950920245398754 0.4093734192071057 0.6822656432492598 1.0 0.9835738350634728 3 P06400,Q07864 2 +Abnormality of the common coagulation pathway 0.350842350521457 0.4084274679161863 0.682959870882244 1.0 0.9840182598452866 11 Q6UN15,Q02750,P49257,P10644,P40763,P38435,Q06124 7 +Sudden death 0.3173248788903436 0.4021866102453887 0.6875466956516469 1.0 0.9875410134089542 19 O15460,P36871 2 +Neoplasm of the male external genitalia 0.3671622021882391 0.401537933745593 0.6880241154206517 1.0 0.9875410134089542 9 Q9UPY3 1 +Abnormality of the musculature of the upper limbs 0.2717036951661987 0.4006729234992318 0.6886609482527377 1.0 0.9875410134089542 56 O75340,P04792,Q14203,P11047,O60568,Q9NR77,Q06124 7 +Astigmatism 0.2851834737033011 0.3970193171676799 0.6913532157696598 1.0 0.9887466357728376 38 P26639,P52732,P55011,P26196,Q15813,O75648,Q8WXI9,Q9BXW9,Q9Y296,Q9UQ13,P61586,Q9NVI1 12 +Lumbar hyperlordosis 0.3427378500256253 0.3956565107901623 0.692358442177536 1.0 0.9887466357728376 13 O75340,P41227,Q96J02 3 +Abnormal t cell subset distribution 0.3825886000145542 0.3954571089476322 0.6925055694702493 1.0 0.9887466357728376 8 Q96MG7,O95394,P17812 3 +Erythrocyte inclusion bodies 0.5901494653148209 0.3953765622667975 0.6925650035807669 1.0 0.9887466357728376 3 P11413 1 +Abnormal uvea morphology 0.2580385823610149 0.3953301787993599 0.6925992300601 1.0 0.9887466357728376 73 O75340,Q13363,P14174,Q15645,P41227,P11047,Q9BXW9,Q9H3P2,Q96AX1,P61586,Q9NR77 11 +Facial edema 0.3013547369392331 0.3932006295862486 0.6941713047469305 1.0 0.9887466357728376 26 Q9NQW6,Q8NFH4,P52565,P28070 4 +Optic nerve hypoplasia 0.3437575206366242 0.3881547183697575 0.697901540667565 1.0 0.9915430456793688 12 P61978,Q8N3U4,Q8WXI9,O75312,Q9NVI1 5 +Arachnodactyly 0.2978081101678736 0.3843109673665352 0.7007479802179313 1.0 0.9915430456793688 27 Q13363,Q92766,Q9H3P2,O60828 4 +Productive cough 0.409020131387178 0.3834782863709838 0.701365166991639 1.0 0.9915430456793688 6 Q6UN15,Q86Y56,P40763 3 +Slanting of the palpebral fissure 0.2533576157543339 0.3830666169024782 0.7016703710271075 1.0 0.9915430456793688 146 P41227,O60828,O75648,Q9H3P2,Q9UQ13,Q06124,Q13363,O75340,Q15645,Q15555,P26196,Q15392,Q9BW83,Q96EK5,Q9Y296,O14646,O15047,O95602,P52732,P35606,Q9H9B1,P55011,P61978,Q9BTW9,Q9UNW1,P83436,Q92766,P21281,O43776,Q13409,Q8WXI9,Q9BXW9,Q8N0X7,Q9NVI1 34 +Osteomalacia 0.5856850715746464 0.3829117979141036 0.7017851633832517 1.0 0.9915430456793688 3 O43175,P53680 2 +Abnormal circulating apolipoprotein concentration 0.5956663941128453 0.3821367427057285 0.702359939429837 1.0 0.9915430456793688 2 Q9Y487 1 +Abnormal subcutaneous fat tissue distribution 0.5956663941128453 0.3821367427057285 0.702359939429837 1.0 0.9915430456793688 2 Q9Y487 1 +Abnormal cutaneous elastic fiber morphology 0.5956663941128453 0.3821367427057285 0.702359939429837 1.0 0.9915430456793688 2 Q9Y487 1 +Thick cerebral cortex 0.5956663941128453 0.3821367427057285 0.702359939429837 1.0 0.9915430456793688 2 Q9Y487 1 +Prominent veins on trunk 0.5956663941128453 0.3821367427057285 0.702359939429837 1.0 0.9915430456793688 2 Q9Y487 1 +Adenomatous colonic polyposis 0.5948487326247014 0.3797412844268036 0.70413747116736 1.0 0.9930719918824924 2 Q07864 1 +Hyporeflexia 0.2562588519535468 0.3775326734433317 0.7057777878067568 1.0 0.9946603486276704 86 Q9BUK6,Q99720,P21281,P23381,O43776,P04792,P41440,P35637,Q9Y281,P83436,P11047,O14979,O95831,Q96AX1,Q9NR77,Q16637 16 +Reticulocytosis 0.3523797154955093 0.3772251880811617 0.7060062632416688 1.0 0.9946603486276704 10 P11413,Q8NBF2 2 +Abnormal circulating progesterone level 0.4063774106605573 0.3743854018945756 0.7081176021751132 1.0 0.996186621201614 6 Q9NR50 1 +Decreased circulating progesterone 0.4063774106605573 0.3743854018945756 0.7081176021751132 1.0 0.996186621201614 6 Q9NR50 1 +Abnormality of the vestibulocochlear nerve 0.5919869174161979 0.3714115950300683 0.7103309906539401 1.0 0.9964020878103508 2 P10644 1 +Neoplasm of the ear 0.5919869174161979 0.3714115950300683 0.7103309906539401 1.0 0.9964020878103508 2 P10644 1 +Neoplasm of the inner ear 0.5919869174161979 0.3714115950300683 0.7103309906539401 1.0 0.9964020878103508 2 P10644 1 +Abnormal clavicle morphology 0.3337325938147257 0.369364471670917 0.7118560760674071 1.0 0.9974199972293466 14 Q96AY3 1 +Alacrima 0.4779389037730028 0.3685511108829968 0.7124623418544282 1.0 0.9974199972293466 4 P55011 1 +Aplasia hypoplasia of the hallux 0.321320086068092 0.3672341405118017 0.7134443752319866 1.0 0.9974199972293466 17 Q13363,P55011,P26196,O75648,Q9H3P2,Q9Y296 6 +Increased blood urea nitrogen 0.5903515944399101 0.3666901186717165 0.7138501780727105 1.0 0.9974199972293466 2 O95163 1 +Abnormality of the distal phalanx of the thumb 0.5795501022494903 0.3660660737523605 0.714315772315194 1.0 0.9974199972293466 3 Q69YN2,O75369 2 +Tibial bowing 0.5795501022494882 0.3660660737523546 0.7143157723151985 1.0 0.9974199972293466 3 Q32P28,O75369 2 +Radial bowing 0.5795501022494882 0.3660660737523546 0.7143157723151985 1.0 0.9974199972293466 3 Q32P28,O75369 2 +Angular cheilitis 0.5793264460557451 0.365458261229804 0.7147693579741228 1.0 0.9975625393892082 3 P20810 1 +Abnormality of skin physiology 0.2551614474504564 0.3619284307372371 0.7174055135184325 1.0 0.9992929102419364 76 P14174,Q9H4L7,Q9UDY2,Q06136,Q5JRA6 5 +Abnormality of the septum pellucidum 0.2897032066292857 0.3587958538806346 0.719747814560451 1.0 0.9992929102419364 32 Q13363,P15311,Q13409,Q9H9B1,Q15392,Q08J23,Q9ULK4,Q9NVI1 8 +Impaired proprioception 0.2956722058133742 0.3586636889559134 0.7198466954208063 1.0 0.9992929102419364 26 O00400,Q9NR77 2 +Thyroid adenoma 0.576687116564415 0.3583196328784123 0.7201041273075628 1.0 0.9992929102419364 3 P10644,Q6P1J9 2 +Decreased circulating level of specific antibody 0.5766871165644144 0.3583196328784108 0.7201041273075639 1.0 0.9992929102419364 3 P50851,P17812 2 +Skeletal muscle atrophy 0.2433571613321791 0.3572638372363163 0.7208942996438059 1.0 0.9995073601959292 128 Q92734,P04792,Q14203,P51530,Q16637,Q9BUK6,Q9BW83,O14979,O00400,O60568,Q9NR77,Q99720,Q9Y2U8,Q9UNW1,P07384,O95831,P83436,Q13126,Q6DKK2,P35637,Q13148,Q15813,P11047,Q03252,P55263,Q92804 26 +Pes cavus 0.2534542436754309 0.3552128174383621 0.7224301631279453 1.0 1.0 71 P04792,O60828,O75648,Q08J23,P23381,Q9BUK6,P26196,O00400,Q9Y296,Q9NR77,Q99720,P55011,P07384,O95831,P50570,P21281,O43776,Q8N0X7,Q5TAQ9 19 +Low frustration tolerance 0.3708723108276848 0.3522124442302242 0.7246789450243196 1.0 1.0 8 Q04637,Q6Y7W6 2 +Abnormal thyroid hormone level 0.584627964022903 0.3503882987267255 0.7260473067593598 1.0 1.0 2 Q93008 1 +Abnormal thyroid stimulating hormone level 0.584627964022903 0.3503882987267255 0.7260473067593598 1.0 1.0 2 P10644 1 +Abnormal bone structure 0.2450732151820409 0.348529819165685 0.7274423235021674 1.0 1.0 133 Q13363,P35606,P48735,O75874,Q15392,Q9UDY2,O95831,Q9BXW9,O60568,P38435,Q15042,O14745,Q96AY3,Q15436,Q5JRA6,Q13126 16 +Abnormal morphology of the radius 0.3450674671043343 0.3483243092998097 0.7275966394296509 1.0 1.0 10 Q15427,P10644,P98175,Q9NVI1,P39019 5 +Alternating esotropia 0.5838103025347591 0.34808820299846 0.7277739436435695 1.0 1.0 2 Q14738 1 +Hand tremor 0.3526675965496512 0.3457351845357895 0.7295417395834602 1.0 1.0 9 Q92734 1 +Abnormality of the peripheral nervous system 0.2533514618730516 0.3441554184884085 0.7307294075471387 1.0 1.0 76 Q99720,Q92734,Q6Y7W6,P04792,P41440,O95831,Q9NR77 7 +Hepatitis 0.3328363642334655 0.3421638459359404 0.7322275916685081 1.0 1.0 12 Q96J02 1 +Abnormality of earlobe 0.2996998270841784 0.3402972234080544 0.733632707923604 1.0 1.0 20 Q15392,Q92766,P98175,Q9H9B1 4 +Pancreatic adenocarcinoma 0.3669197006164207 0.3380656241851189 0.7353137349189232 1.0 1.0 8 Q8WX93,P43246,P52701 3 +Poor appetite 0.3503550758997011 0.3371355151749088 0.7360147457498891 1.0 1.0 9 Q70HW3 1 +Radial deviation of the hand or of fingers of the hand 0.3502161182994774 0.3366215517706109 0.7364022074980499 1.0 1.0 9 P41227 1 +Shoulder dislocation 0.5793131643499677 0.3355683106097192 0.7371964240929316 1.0 1.0 2 Q6ZXV5 1 +Spondylolysis 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 1.0 2 O75369 1 +Broad face 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 1.0 2 O75369 1 +Ureteral stenosis 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 1.0 2 Q9UBM7 1 +Ureteral obstruction 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 1.0 2 Q9UBM7 1 +Capitate hamate fusion 0.5793131643499676 0.3355683106097189 0.7371964240929318 1.0 1.0 2 O75369 1 +Abnormality of the plantar skin of foot 0.2871525136469925 0.3354092862604417 0.7373163638521341 1.0 1.0 31 Q06136 1 +Visual hallucinations 0.4666889715757145 0.3352616969194777 0.7374276847936603 1.0 1.0 4 Q6Y7W6 1 +Lewy bodies 0.4666889715757145 0.3352616969194777 0.7374276847936603 1.0 1.0 4 Q6Y7W6 1 +Peripheral axonal degeneration 0.2683919034692072 0.3325558747608257 0.7394695559973543 1.0 1.0 49 Q92734,P04792,P41440,P07384,O95831,P40763,P23381,Q6DKK2 8 +Difficulty climbing stairs 0.3399433351829863 0.3286104424927532 0.7424501540798487 1.0 1.0 10 Q92734 1 +Abnormal delayed hypersensitivity skin test 0.5764513491414642 0.3277176324737412 0.7431251702278465 1.0 1.0 2 Q96MG7 1 +Reduced delayed hypersensitivity 0.5764513491414642 0.3277176324737412 0.7431251702278465 1.0 1.0 2 Q96MG7 1 +Fibroadenoma of the breast 0.5764513491414641 0.3277176324737409 0.7431251702278467 1.0 1.0 2 P10644 1 +Zonular cataract 0.4181440777857182 0.3259371875636731 0.7444718790871225 1.0 1.0 5 Q15436 1 +Keratitis 0.3464534645346522 0.3228265550274732 0.7468266008680451 1.0 1.0 9 P50747,P26639,Q14739,P01889,P49327,Q9NSE4,P18074,Q15149 8 +Monotonic speech 0.4156246514870474 0.3182237624660204 0.7503152090833054 1.0 1.0 5 Q6Y7W6 1 +Abnormal speech prosody 0.4156246514870474 0.3182237624660204 0.7503152090833054 1.0 1.0 5 Q6Y7W6 1 +Hemolytic anemia 0.2868908338956322 0.3178931688419945 0.7505659745103628 1.0 1.0 27 P11413,Q8NBF2,P41440,P48506,P40763 5 +Abnormality of taste sensation 0.5723630417007446 0.316662229950329 0.751499911062927 1.0 1.0 2 O95163 1 +Decreased corneal reflex 0.5723630417007446 0.316662229950329 0.751499911062927 1.0 1.0 2 O95163 1 +Gastrostomy tube feeding in infancy 0.2862709669181495 0.3166223866732923 0.7515301469990816 1.0 1.0 28 Q99720,Q96J02,P35637 3 +Abnormality of t cell physiology 0.3259625963975711 0.3143628843701372 0.7532454422494694 1.0 1.0 12 O95394,P11172,Q96MG7,Q92766,P17812 5 +Aplasia hypoplasia of the skin 0.2691737240207444 0.3118465357014465 0.7551571559007915 1.0 1.0 40 Q13363,Q9Y2U8,Q9H4L7,Q15392,Q9H3P2,Q13126 6 +Dyscalculia 0.3750450540540831 0.3102877735723777 0.7563421279271101 1.0 1.0 7 P35637 1 +Neoplasm of the oral cavity 0.3740887350060274 0.3071485855589002 0.7587302778867606 1.0 1.0 7 P43246,Q12824 2 +Limited elbow movement 0.2863209931782348 0.3039229478616826 0.761186594382186 1.0 1.0 26 Q96AY3,O60568,Q96J02 3 +Spastic hyperactive bladder 0.4103956481924182 0.3024720363891307 0.7622922474464691 1.0 1.0 5 Q6Y7W6 1 +Unilateral renal agenesis 0.3072650806408446 0.3016375019226026 0.7629284163651329 1.0 1.0 17 Q7LGA3,P35606,Q2VPK5,Q15427,P10644,Q86XL3,P60953,P30153,Q06124 9 +Eclabion 0.2840823257202013 0.3014187655022852 0.7630951865093825 1.0 1.0 27 Q9H9B1,P41227,Q96EK5,Q15042,O15047 5 +Soft tissue sarcoma 0.2836902438877821 0.3012850180410168 0.7631971643529503 1.0 1.0 28 P21281,Q15645,Q15392,Q9UPY3,P43246,Q13126,Q06124 7 +Diffuse cerebellar atrophy 0.4099752534505269 0.3012209761244152 0.7632459955688753 1.0 1.0 5 P26639 1 +Heat intolerance 0.4545854432929855 0.3010020994956036 0.763412893560762 1.0 1.0 4 P00338,P61978 2 +Abnormality of skeletal muscle fiber size 0.3143097376069808 0.2991324479526814 0.7648389892218574 1.0 1.0 15 Q9BUK6,O95831,Q9Y281 3 +Abnormal renal pelvis morphology 0.2765596000123256 0.2985463901333305 0.76528617520944 1.0 1.0 35 P21281,P26196,P41227,Q8N0X7,P98175,Q08J23,Q15042,O75718,P83436,Q5JRA6 10 +Sloping forehead 0.2779302403571064 0.2983757085358334 0.765416426939759 1.0 1.0 34 P52732,P35606,Q15645,Q13409,Q8N3U4,Q15021,Q96EK5,Q9BXW9,P98175,Q08J23,Q86XL3,P08243,O43683,Q9NVI1 14 +Allergy 0.3825426554961222 0.2963878099762015 0.7669339335841938 1.0 1.0 6 O14646 1 +Failure of eruption of permanent teeth 0.5641864268193058 0.2951274648235994 0.7678965097438897 1.0 1.0 2 O75369 1 +Type i transferrin isoform profile 0.4077820421263678 0.2947317140970617 0.7681988343952988 1.0 1.0 5 P36871 1 +Prolonged partial thromboplastin time 0.4077283997822021 0.2945737910346857 0.7683194859275009 1.0 1.0 5 Q7Z2Z2,P38435 2 +Elevated circulating growth hormone concentration 0.5637775960752338 0.294071224690392 0.7687034785837636 1.0 1.0 2 P10644 1 +Pituitary prolactin cell adenoma 0.5637775960752338 0.294071224690392 0.7687034785837636 1.0 1.0 2 P10644 1 +Generalized hypopigmentation 0.3686222608801157 0.2894657292631127 0.7722250019317269 1.0 1.0 7 Q9Y2U8 1 +Insidious onset 0.4503076532572039 0.2892990242306918 0.772352558959863 1.0 1.0 4 Q9NR77 1 +Widened subarachnoid space 0.2885802295078032 0.2892871678580965 0.7723616312877986 1.0 1.0 22 O95831,Q01105 2 +Papule 0.3161334053806841 0.2842715216402364 0.7762023086950958 1.0 1.0 13 Q9Y2U8,P38435,P40763 3 +Clinodactyly 0.238278981986211 0.2840960326950272 0.7763367872155729 1.0 1.0 105 Q7LGA3,Q15427,P41227,O60828,O75648,P98175,Q08J23,Q12824,P61586,O43683,Q5JRA6,P11233,Q06124,Q15645,P26196,Q6DKJ4,Q92785,P57081,Q96EK5,Q9Y296,Q9Y2U8,P55011,Q07864,P60953,P09884,P21281,O43776,Q7Z6Z7,Q8N3U4,Q03252,Q9BXW9,Q8NFH4,Q8N0X7,Q96J02,Q9NVI1,P30153 36 +Omphalocele 0.3495901639344309 0.2789056137548231 0.7803172602759574 1.0 1.0 8 P36776,Q8TD19,P21333,Q6DKJ4,Q14739,O75369,Q69YQ0 7 +Delayed eruption of teeth 0.270244878883433 0.2779098351689874 0.781081573824034 1.0 1.0 37 P21281,P41227,P40763,Q08J23,Q15436,Q5JRA6 6 +Abnormality of pancreas physiology 0.2718441168391232 0.2776345970747645 0.7812928711908405 1.0 1.0 36 Q15904,Q8WX93,P14174 3 +Insulin resistance 0.3140822935090941 0.2762926261739307 0.7823233190390972 1.0 1.0 13 Q03252,P17096 2 +Puberty and gonadal disorders 0.2342783125475547 0.2760173525594374 0.7825347383506802 1.0 1.0 123 Q13363,P48735,Q5JRA6,O75874 4 +Downslanted palpebral fissures 0.2358908967331134 0.2752437166596274 0.7831290024770592 1.0 1.0 107 Q7LGA3,Q15427,P41227,O75648,P11172,Q9H3P2,Q9UQ13,O43683,Q06124,Q13363,O75340,Q15645,Q15555,P26196,Q6DKJ4,Q15392,Q92785,Q9BW83,Q96EK5,Q9Y296,O14646,O15047,O95602,P52732,P55011,P61978,P60953,Q92766,P21281,Q7Z6Z7,Q9H9Y6,Q8N0X7,P30153,P39019 34 +Abnormal soft palate morphology 0.2545980556527168 0.2729624347672461 0.7848820920774222 1.0 1.0 58 P21281,P61978,Q15392,Q15813,Q9BXW9,O75312,Q9C0B1,Q9BUF5,P46777,Q15436,Q9NVI1,P36871 12 +Simplified gyral pattern 0.2844481287245622 0.2723573432771242 0.7853472684342275 1.0 1.0 23 P52732,P35606,Q13409,Q92785,Q03252,Q86XL3,Q12824,P08243,Q9Y3C6 9 +Abnormal enchondral ossification 0.2913911813782832 0.2720794190591364 0.785560954018061 1.0 1.0 19 Q13363 1 +Abnormal serum interferon level 0.3997181263891436 0.2714249534388408 0.7860642120684722 1.0 1.0 5 Q5TBB1 1 +Neoplasm of the thyroid gland 0.2859846849564724 0.2709892604347609 0.7863992922559742 1.0 1.0 20 Q9UPY3 1 +Abnormal muscle fiber morphology 0.2582944394870055 0.2703167736116649 0.7869165620684921 1.0 1.0 53 Q9BUK6,O75340,Q99720,Q70HW3,Q9Y281,P61978,P35637,Q9H2D1,P11047,O14979,O75648,O95831,P50570,P35609 14 +Keratoconjunctivitis 0.3463114754098415 0.2682681293326072 0.7884929364580384 1.0 1.0 8 P50747,P26639,Q14739,P01889,P49327,Q9NSE4,P18074 7 +Microcornea 0.2952426401381415 0.2678972774050935 0.7887783894431271 1.0 1.0 18 Q15042,P41227,O15347,Q15555 4 +Abnormal libido 0.5531479967293635 0.2673103360621249 0.7892302292120157 1.0 1.0 2 O00170 1 +Anosmia 0.5531479967293635 0.2673103360621249 0.7892302292120157 1.0 1.0 2 A6NHR9 1 +Posterior pituitary dysgenesis 0.5531479967293633 0.2673103360621243 0.7892302292120161 1.0 1.0 2 Q9UHX1 1 +Breast hypoplasia 0.5531479967293633 0.2673103360621243 0.7892302292120161 1.0 1.0 2 Q93008 1 +Dystrophic fingernails 0.3613560252707219 0.2666696910171294 0.7897234921375507 1.0 1.0 7 P40763 1 +Abnormal tendon morphology 0.2486820258246589 0.2650322125559024 0.7909846468178354 1.0 1.0 158 P34913,Q92734,P41227,P51530,O60828,Q96AY3,O75340,Q9H4L7,Q9Y3C8,Q15392,P57081,O60568,P28070,Q9NR77,Q99720,Q9Y281,P41440,O75352,O95831,Q15042,P35637,P40763,Q96AX1,Q96J02 24 +Respiratory failure requiring assisted ventilation 0.396911033335612 0.2635204372418129 0.792149473419014 1.0 1.0 5 O75648,Q9BTW9,Q92734 3 +Dyspareunia 0.537948860498145 0.2612512419133573 0.7938987644329678 1.0 1.0 3 O00170 1 +Furrowed tongue 0.5378506121420734 0.2610244798855607 0.7940736292648192 1.0 1.0 3 Q15042 1 +X linked recessive inheritance 0.265379108760746 0.257300732816224 0.7969466267887597 1.0 1.0 38 Q15904,O95831 2 +Abnormality of periauricular region 0.2881400604264625 0.2570589513097021 0.7971332650594551 1.0 1.0 19 Q13363 1 +Broad toe 0.2823217315053759 0.2549458820013694 0.7987648981247948 1.0 1.0 21 Q7LGA3,P55011,Q7Z6Z7,P26196,P41227,O75648,Q9Y296,P61586,P30153 9 +Redundant neck skin 0.4365793780687333 0.2532434372376951 0.8000801021431534 1.0 1.0 4 Q9Y487,P82650,P38606 3 +Severe viral infection 0.4361257570592165 0.2520922303423301 0.8009697753605336 1.0 1.0 4 P17812 1 +Dysuria 0.3562453051588508 0.2511381042360264 0.801707336779893 1.0 1.0 7 Q8N0X7 1 +Abnormality of immune serum protein physiology 0.3672325912373638 0.2504700676600923 0.8022238496528018 1.0 1.0 6 Q5TBB1 1 +Pulmonary hemorrhage 0.3671210220622499 0.2501484267727787 0.8024725669627444 1.0 1.0 6 Q6UN15,P40763,P10644 3 +Delayed closure of the anterior fontanelle 0.323061907541546 0.2427072428800699 0.8082321961935779 1.0 1.0 9 Q15436 1 +Abnormal forearm bone morphology 0.3049158142884592 0.2418096519760991 0.8089276596305126 1.0 1.0 13 Q15427,P10644,Q9BXW9,P98175,Q9NVI1,P39019 6 +Abnormal bronchoalveolar lavage fluid morphology 0.5408830744072052 0.2381534589109593 0.8117620730495778 1.0 1.0 2 P53621 1 +Equinovarus deformity 0.3872796798433144 0.2372469153570522 0.812465241866489 1.0 1.0 5 Q9NR77 1 +Syncope 0.3512822185877259 0.2364649212138564 0.813071924318759 1.0 1.0 7 P0DP25 1 +Abnormal sharpey fiber morphology 0.4291248931225901 0.2346607200887031 0.8144720772984846 1.0 1.0 4 P53680 1 +Sleep apnea 0.2822173818371065 0.2305191868719154 0.8176883559392929 1.0 1.0 19 Q14203,P11047 2 +Inflammatory abnormality of the eye 0.2707574440500531 0.2298438502495211 0.8182131091777036 1.0 1.0 29 P14174 1 +Spina bifida 0.270783387595978 0.2272021437794218 0.8202665607891795 1.0 1.0 27 P21281,Q9BXW9,Q08J23,Q92766,Q9NVI1,Q06124 6 +Inverted nipples 0.4256711401629759 0.2262964084241839 0.820970891607951 1.0 1.0 4 P83436 1 +Abnormality iris morphology 0.2486540544719438 0.2262195474167981 0.8210306680120407 1.0 1.0 58 O75340,Q13363,P41227,P11047,Q9BXW9,Q9H3P2,P61586,Q9NR77 8 +Gastrointestinal obstruction 0.3035433049837319 0.2259825766972693 0.8212149716100796 1.0 1.0 11 Q8WX93,Q01844 2 +Abnormal oral physiology 0.2546310745228125 0.2250632865934295 0.8219300413408632 1.0 1.0 47 P35637,Q13148,Q14203,P11047,Q03252,P40763,Q9NR77,Q92804,O15460 9 +Intestinal polyp 0.2928277646384684 0.224977562310402 0.8219967295182098 1.0 1.0 16 Q9UPY3,P43246 2 +Carcinoma 0.3825743046528527 0.2249007883356554 0.8220564560023855 1.0 1.0 5 P43246 1 +Abnormal serum insulin like growth factor 1 level 0.533932951757982 0.2224729151575065 0.8239457555468732 1.0 1.0 2 O00170 1 +Adrenocorticotropin deficient adrenal insufficiency 0.533932951757982 0.2224729151575065 0.8239457555468732 1.0 1.0 2 O00170 1 +Impaired smooth pursuit 0.2992351007101431 0.2214409744290986 0.8247490912382838 1.0 1.0 13 P41440 1 +Abnormal subarachnoid space morphology 0.2720546826207485 0.2196640175885654 0.8261328299973705 1.0 1.0 25 O95831,Q01105 2 +Abnormality of the cheek 0.2537808868950437 0.219107498253764 0.8265663099255507 1.0 1.0 47 Q13363,P52732,P41227,Q15813,Q00535,Q96AX1,O15047 7 +Exaggerated cupid s bow 0.4225346934116173 0.2188373515440424 0.8267767496702725 1.0 1.0 4 P11233,P61978 2 +Blue sclerae 0.290946403101596 0.2177715235239894 0.827607133009145 1.0 1.0 16 O75718,Q96AY3,Q9H3U1 3 +Abnormal macroscopic urine appearance 0.2834261490515467 0.2171667047006755 0.8280784312835743 1.0 1.0 18 Q9NQW6,Q8NFH4,P52565 3 +Abnormality of the palpebral fissures 0.2477178048092028 0.2165654401839259 0.8285470212676604 1.0 1.0 167 P41227,O60828,O75648,P98175,Q9H3P2,Q08J23,Q9UQ13,P61586,Q06124,Q13363,O75340,Q15645,Q15555,O95394,P26196,Q15392,Q9BW83,Q96EK5,Q9Y296,O14646,O15047,O95602,P52732,P35606,Q9H9B1,P55011,P61978,Q9UNW1,P83436,Q92766,P21281,O43776,Q13409,Q8WXI9,Q9BXW9,Q8N0X7,Q9NVI1 37 +Long penis 0.5298446443172626 0.2135386814084313 0.83090682139767 1.0 1.0 2 O00170 1 +Flexion contracture of digit 0.2529289265803263 0.2131820173506353 0.8311849939594989 1.0 1.0 47 Q9H4L7,P41227,P57081,Q15042,Q96J02 5 +Abnormality of the achilles tendon 0.3132861895026554 0.2123411843463389 0.8318408674641469 1.0 1.0 9 Q92734 1 +Bradykinesia 0.2891096377134501 0.2108321080991689 0.8330182829958739 1.0 1.0 16 Q6Y7W6,Q14203,Q6DKK2 3 +Dental malocclusion 0.2720394350193681 0.2069020367975908 0.8360863658023125 1.0 1.0 21 P21281,P61586,Q06124 3 +Retrognathia 0.2450823789157969 0.2062403448205604 0.836603174590647 1.0 1.0 59 Q13363,Q15392,Q5JRA6,Q9C0B1 4 +Hemoptysis 0.5124744376278195 0.2059902889986495 0.836798496900186 1.0 1.0 3 P31153,P49327 2 +Abnormality of toe 0.2307493287658866 0.204964413046582 0.8375999289971117 1.0 1.0 128 Q13363,Q99720,P04792,Q9H4L7,P61586,Q9NR77,Q5JRA6,Q96J02 8 +Dilation of lateral ventricles 0.283827412936718 0.2035850961233317 0.8386777407998047 1.0 1.0 17 O75340,Q01105 2 +Abnormality of the nasal skeleton 0.4157119476268384 0.2030677528670207 0.839082076070645 1.0 1.0 4 P10644,Q6NUK1,P22314 3 +Abnormality of the phalanges of the toes 0.296500301178646 0.2028393817240182 0.8392605755520124 1.0 1.0 11 P21281,Q7LGA3,Q9NVI1,Q9BXW9 4 +Recurrent lower respiratory tract infections 0.2710963364880502 0.2026778814723119 0.839386812390887 1.0 1.0 21 O95394,Q9BTW9,P11047,P40763,Q96AX1 5 +Abnormal hypothalamus physiology 0.4155330834960754 0.2026628313191525 0.8393985765692049 1.0 1.0 4 Q12824 1 +Abnormality of vitamin d metabolism 0.3245901639344314 0.2026535801626437 0.8394058078924789 1.0 1.0 8 Q7Z2Z2,Q10471,P61011,Q9Y3A5,P46783,P41252,P62913 7 +Cns hypomyelination 0.2638492608595998 0.2012760387965794 0.8404827374294843 1.0 1.0 32 O75340,Q99720,O00400,P35637 4 +Rectal prolapse 0.3240787382672401 0.2012149334445546 0.8405305150925892 1.0 1.0 8 P41227 1 +Neoplasm 0.2505876444491075 0.2009874280069017 0.8407084044808231 1.0 1.0 182 P48735,O75874,O76094,Q9H3P2,Q06136,Q08J23,Q12824,P43246,P17812,Q06124,Q13363,Q9BUK6,Q8WX93,Q15645,Q15555,Q9H4L7,Q15392,Q9UDY2,Q9UPY3,P52732,Q9Y2U8,Q9UNW1,Q9NVI1,Q13126,Q5TBB1,P21281,Q9BXW9,P40763,Q01844,P46777,P11802,Q15436,Q92804 33 +Bilateral microphthalmos 0.4128477905073549 0.1966363495915288 0.8441121230544582 1.0 1.0 4 P26639,P18074,Q9UHX1 3 +Neurogenic bladder 0.5077150823966631 0.1964731141033281 0.8442398743839592 1.0 1.0 3 P83436 1 +Red eye 0.2850990626221122 0.1960139995188955 0.8445992085177112 1.0 1.0 16 P28070 1 +Lissencephaly 0.2537935121745687 0.1940929680612549 0.8461030876046634 1.0 1.0 39 P35606,Q15392,P57081,Q9C0B1,Q9Y320 5 +Abnormal neural tube morphology 0.2607323755492538 0.1937969620554579 0.8463348658471224 1.0 1.0 34 P21281,Q99707,Q9BXW9,Q08J23,Q92766,Q9NVI1,Q06124 7 +Congenital sensorineural hearing impairment 0.5055214723926448 0.192174118374371 0.8476058185785365 1.0 1.0 3 Q8WWQ0,Q15046 2 +Bone marrow hypercellularity 0.3205057203879672 0.1913056341610164 0.8482861471913747 1.0 1.0 8 Q6UN15,P40763 2 +Generalized amyotrophy 0.2681312994130727 0.1906117559950006 0.8488297791157331 1.0 1.0 22 Q9Y2U8,P51530,Q03252,P35637 4 +Nevus 0.2669485431200539 0.1902669968370154 0.8490999139295972 1.0 1.0 24 Q96AY3,Q9Y2U8,Q06124 3 +Abnormal renal collecting system morphology 0.3345312474973591 0.1900555526157145 0.8492655990670657 1.0 1.0 7 Q9BXW9 1 +Abnormality of the musculature of the lower limbs 0.2763707923477332 0.1889006038567514 0.8501707202876643 1.0 1.0 18 Q14331,Q9NR77,O14979 3 +Impaired tactile sensation 0.3340246174506966 0.1887291926136942 0.850305070338403 1.0 1.0 7 O43776,Q9NR77 2 +Rod cone dystrophy 0.2644977343363265 0.1879194037139483 0.8509398317486947 1.0 1.0 26 P22570,P38435,Q9BW83 3 +Abnormal pancreas size 0.3333527539515432 0.1869774102397517 0.8516783446016745 1.0 1.0 7 Q7Z2Z2,P40763 2 +Bruxism 0.3653110988629926 0.1824746609929726 0.8552102381081719 1.0 1.0 5 P61978 1 +Brittle hair 0.2875401954268528 0.1820513271956498 0.8555424455928122 1.0 1.0 13 Q15436,O60828 2 +Absent testis 0.4054996332434899 0.1806538872981235 0.856639255741884 1.0 1.0 4 Q9BXW9 1 +Rhizomelia 0.2958459450591832 0.1801075006804103 0.8570681742118449 1.0 1.0 10 Q15392 1 +Impaired adp induced platelet aggregation 0.513082583810313 0.1791878122866714 0.8577902332336633 1.0 1.0 2 P27797 1 +Diffuse alveolar hemorrhage 0.3637697548878428 0.1789117392281854 0.858007004942885 1.0 1.0 5 Q6UN15,P40763 2 +Addictive behavior 0.3637697548878428 0.1789117392281854 0.858007004942885 1.0 1.0 5 Q6UN15,P40763 2 +Metrorrhagia 0.3637697548878428 0.1789117392281854 0.858007004942885 1.0 1.0 5 Q6UN15,P40763 2 +Neoplasm of striated muscle 0.3136215412898311 0.1729214839391054 0.8627131442966876 1.0 1.0 8 Q9UPY3 1 +Rhabdomyosarcoma 0.3136215412898311 0.1729214839391054 0.8627131442966876 1.0 1.0 8 Q9UPY3 1 +Finger clinodactyly 0.2374011433392472 0.1722069805741818 0.8632748101614693 1.0 1.0 62 P21281,Q15645,Q9Y2U8,P41227,O60828,Q03252,P57081,Q9BXW9,Q8NFH4,Q9NVI1,Q5JRA6,Q06124 12 +Delayed cranial suture closure 0.263502192350406 0.171820720648542 0.8635784750594835 1.0 1.0 23 Q15813,P41227,Q08J23,O75718,Q15436 5 +Abnormal platelet volume 0.3125496519924319 0.1701440106907351 0.8648968825528391 1.0 1.0 8 P35579,O15143,P60953 3 +Prominent digit pad 0.2793406995417641 0.1674377625057727 0.8670256143697359 1.0 1.0 15 Q7LGA3,Q7Z6Z7,P55011,P26196,P41227,O75648,Q9Y296 7 +Elbow flexion contracture 0.2669577559552006 0.1673581536025892 0.8670882493269723 1.0 1.0 19 Q96AY3 1 +Pelvic girdle muscle weakness 0.3254445078828684 0.1669774998565067 0.8673877528736023 1.0 1.0 7 O14979 1 +Abnormally folded helix 0.2787896605948382 0.1656295197521726 0.8684485147465766 1.0 1.0 15 Q92766,O43776,P41227 3 +Limb girdle muscle atrophy 0.3106360465957682 0.1652430058257481 0.8687527167489728 1.0 1.0 8 O14979 1 +Low levels of vitamin d 0.3244571896763579 0.1645615589502917 0.8692890901396226 1.0 1.0 7 Q7Z2Z2,Q10471,P61011,Q9Y3A5,P46783,P62913 6 +Abnormal leukocyte physiology 0.2452750083144876 0.1645227279109092 0.8693196562380332 1.0 1.0 49 P14174,P48506,Q15904,P40763,P28070,Q96AX1,Q96J02,Q92766,P17812 9 +Severe varicella zoster infection 0.4895742105364127 0.1625994431169787 0.8708338254860444 1.0 1.0 3 P17812 1 +Hypomimic face 0.3335240099536906 0.1625140604161654 0.8709010568464903 1.0 1.0 6 Q6Y7W6 1 +Flat face 0.2725521816389918 0.1621252661662324 0.8712072098804406 1.0 1.0 17 O60568,Q15555 2 +Abnormality of the intervertebral disk 0.3228150046822309 0.1605833795382532 0.8724215462040643 1.0 1.0 7 P57081 1 +Systemic lupus erythematosus 0.3952536824877263 0.1596303706223106 0.8731722534554474 1.0 1.0 4 Q9UJV9,P49327,P00491 3 +Hypoplasia of the pons 0.2769115004973146 0.1595325469766221 0.8732493178873375 1.0 1.0 15 Q9UNW1 1 +Sensory axonal neuropathy 0.2870198419283134 0.1554778223889949 0.8764446364956597 1.0 1.0 10 O95831 1 +Hodgkin lymphoma 0.3206514228386289 0.1554190840181337 0.8764909400963639 1.0 1.0 7 P40763,O95394 2 +Atrial arrhythmia 0.2928728122138289 0.1554174228773819 0.8764922495838083 1.0 1.0 9 P35609,P07741 2 +Abnormal renal medulla morphology 0.3203605079885265 0.15473138923021 0.8770330829752697 1.0 1.0 7 P36776,Q8TD19,O60231,Q16658,Q9NQH7,P53680 6 +Hypophosphatemia 0.3907796173776851 0.1509168076864602 0.8800413417292341 1.0 1.0 4 P53680,O14745 2 +Personality changes 0.2787105334289849 0.1497185541272397 0.8809866691029073 1.0 1.0 11 Q9NR50,Q14203 2 +Abnormality of the antihelix 0.2902864028604556 0.1488566825923618 0.8816667225873638 1.0 1.0 9 P98175,Q15042 2 +Abnormal 5th finger morphology 0.2307512023520361 0.1486666024647744 0.8818167156944292 1.0 1.0 74 P21281,Q15645,Q9Y2U8,P41227,O60828,Q9BW83,P57081,Q03252,Q9BXW9,Q8NFH4,Q08J23,Q9NVI1,Q5JRA6,Q06124 14 +Intestinal pseudo obstruction 0.3173333661127012 0.1476700729747699 0.882603150959518 1.0 1.0 7 Q8WX93 1 +Prenatal movement abnormality 0.2429984559522635 0.1468783739479727 0.8832280218644402 1.0 1.0 46 Q13363,Q70HW3,P51530,Q16637,P43897 5 +Eczema 0.2535062510296614 0.1462619770043122 0.883714580961789 1.0 1.0 32 P50747,P26639,Q7Z2Z2,O95394,Q07864,Q96MG7,Q9Y3A5,Q08J23,P40763,Q9UQ13,Q92766 11 +Spina bifida occulta 0.2726532861406371 0.1460918098042183 0.8838489118790891 1.0 1.0 15 P21281,Q08J23,Q06124 3 +Ecchymosis 0.2828082801233337 0.1443729697306747 0.8852059602026716 1.0 1.0 10 Q6UN15,Q9Y3A5,P38435,P40763 4 +Fine hair 0.2764210295780639 0.143456808092175 0.8859294205051427 1.0 1.0 11 Q8WXI9,P41227 2 +Aplasia hypoplasia of the breasts 0.3471142038477295 0.1428368764456926 0.8864190124834055 1.0 1.0 5 Q8WWQ0,Q93008,P82650,P57740 4 +Myotonia 0.3471142038477294 0.1428368764456926 0.8864190124834055 1.0 1.0 5 P50402,Q9BTV4,Q00577,P08237 4 +Type 1 muscle fiber atrophy 0.3471142038477294 0.1428368764456926 0.8864190124834055 1.0 1.0 5 P50402,P06753,Q9BTV4,P61978 4 +Abnormal breath sound 0.3012623552304848 0.1423122671694344 0.8868333573473102 1.0 1.0 8 Q86TI2 1 +Abscess 0.3240810696913476 0.1413638662468649 0.8875824981242169 1.0 1.0 6 Q8WX93 1 +Aplasia hypoplasia of the phalanges of the thumb 0.3004453292162848 0.1403990686188008 0.8883446936992496 1.0 1.0 8 Q9BXW9 1 +Scleroderma 0.3458862054850605 0.140354934120113 0.8883795626774038 1.0 1.0 5 P28340,Q14739,Q9Y2U8,P02545 4 +High anterior hairline 0.270265560220814 0.1387896239833378 0.8896163934897952 1.0 1.0 15 Q13363,Q9H3P2 2 +Onycholysis 0.3450675399099479 0.1387139901902783 0.8896761624099854 1.0 1.0 5 P10321,O15446,P06132,P20810 4 +Spinal canal stenosis 0.3226863226863196 0.1383743359561332 0.8899445788195888 1.0 1.0 6 Q8IWS0,P10644,Q15813,O00170,Q9NSE4 5 +Neoplasm of the rectum 0.2743518583325738 0.1379128771367933 0.8903092731779365 1.0 1.0 11 Q9UPY3,P43246,P52701 3 +Abnormality of the musculature of the hand 0.2526901260661511 0.1372355776746838 0.8908445900236817 1.0 1.0 29 Q14203,O60568,Q9NR77,P11047 4 +Gout 0.4740286298568538 0.1366388504360101 0.8913162662810494 1.0 1.0 3 P61619,P08237 2 +Aplasia hypoplasia affecting the eye 0.2299086907785675 0.1361073539297341 0.8917364140367663 1.0 1.0 77 Q13363,P52732,Q15645,Q15555,P41227,P11047,O60828,Q15813,Q8WXI9,Q9BXW9,O75312,Q15042,P61586,Q92766,O15347 15 +Abnormality of circulating fibrinogen 0.3208141009891547 0.1344161140278683 0.8930735401132155 1.0 1.0 6 Q6UN15,P40763,P10644 3 +Anodontia 0.4873262469337808 0.1336488449387506 0.8936802579557055 1.0 1.0 2 P21333 1 +Multicystic kidney dysplasia 0.2714089399791798 0.1336395683329385 0.8936875938108377 1.0 1.0 13 Q9BW83 1 +Abnormal connection of the cardiac segments 0.2404549066814952 0.1314835247053186 0.8953928188052303 1.0 1.0 44 P21281,Q9H9B1,O60828,Q9BXW9,P98175,P46777,Q92766,Q9NVI1,O15460 9 +Abnormality of the incisor 0.2536953489553258 0.1301197613296791 0.8964716757566911 1.0 1.0 22 P21281,Q7LGA3,P55011,Q7Z6Z7,P26196,P41227,O75648,Q8WXI9,Q9Y296 9 +Irregular hyperpigmentation 0.2365342923575096 0.1288239823598131 0.8974969284694247 1.0 1.0 56 Q15645,Q15555,Q9H4L7,P55011,P26196,Q15436,O75648,Q9BXW9,Q06136,Q9Y296,Q9UQ13,P43246,Q9NVI1,Q06124 14 +Neuronal loss in the cerebral cortex 0.3392203755318912 0.1273128930009742 0.8986927562055633 1.0 1.0 5 P35637 1 +Adrenal hyperplasia 0.3777189569566807 0.1271189228059949 0.8988462747261956 1.0 1.0 4 P10644,P21281 2 +Bilateral ptosis 0.2700954648874777 0.1268546988962887 0.89905540193177 1.0 1.0 11 P40763,P11047 2 +Dilated third ventricle 0.4820114472608438 0.1253452167535222 0.900250256639425 1.0 1.0 2 P26358 1 +Nail dystrophy 0.2524517298172425 0.1252927720651067 0.9002917741501031 1.0 1.0 22 P40763,O60828,Q9H4L7 3 +Self mutilation 0.2802976371372421 0.1249329697738744 0.9005766167413798 1.0 1.0 9 Q8WXI9,P30566,P41227,Q4G0J3 4 +Thin ribs 0.2749595345460337 0.1248128252101027 0.9006717337441892 1.0 1.0 10 O95831,Q15813 2 +Knee flexion contracture 0.2520577287985826 0.1237765534202414 0.901492196692653 1.0 1.0 22 Q96AY3 1 +Underdeveloped supraorbital ridges 0.29265505657812 0.1228522793727132 0.9022240748186484 1.0 1.0 8 P52732,P98175 2 +Iris coloboma 0.2500191395927148 0.1214773048479856 0.9033129896742296 1.0 1.0 26 O75340,Q13363,P41227 3 +Abnormality of vitamin a metabolism 0.3741189598420728 0.1209898749842148 0.9036990548702613 1.0 1.0 4 Q7Z2Z2 1 +Impaired t cell function 0.2782147515429505 0.1202294092368959 0.9043014215435464 1.0 1.0 9 Q92766,P17812 2 +Hypermetropia 0.2396360332859472 0.119784314770371 0.9046540074714748 1.0 1.0 40 P52732,Q9H9B1,P26196,O60828,Q15904,Q8WXI9,Q9UQ13 7 +Muscle fiber atrophy 0.256687535297016 0.1186871443880869 0.9055232218435684 1.0 1.0 18 Q99720,P11047,P35609,P35637 4 +Thick corpus callosum 0.4775143090760542 0.1186082804249211 0.9055857048354724 1.0 1.0 2 Q7LBC6 1 +Anterior pituitary dysgenesis 0.4775143090760542 0.1186082804249211 0.9055857048354724 1.0 1.0 2 Q9NW13 1 +Recurrent pneumonia 0.2600125751196773 0.1142569948748136 0.9090340722980372 1.0 1.0 16 Q96AX1,Q9BTW9,P40763,O95394 4 +Aplasia hypoplasia of the extremities 0.2285350400606677 0.1139105413467837 0.9093087091758354 1.0 1.0 141 Q13363,P48735,O75874,Q15392,Q96AY3,Q5JRA6 6 +Cutis marmorata 0.2610158905550765 0.1121154421727987 0.9107318735391066 1.0 1.0 15 Q08J23,Q9C0B1,Q5TBB1 3 +Short digit 0.2142689911398378 0.1115967723014747 0.9111431313671357 1.0 1.0 114 O75648,Q9H3P2,Q06136,Q08J23,Q12824,Q9UQ13,P61586,Q5JRA6,Q06124,Q13363,O95394,P26196,P38435,Q9Y296,Q9H9B1,O95831,Q9C0B1,P21281,Q03252,Q9BXW9,Q8N0X7,P46777,Q9NVI1 23 +Absent toe 0.2479010151068754 0.1110199334344355 0.911600539849686 1.0 1.0 20 Q13363,Q7LGA3,P55011,Q7Z6Z7,P26196,O75648,Q9H3P2,Q9Y296 8 +Gliosis 0.2450639083321913 0.1107193198974054 0.911838925112506 1.0 1.0 34 Q92734,Q9H9B1,P35637,Q13148,Q9NR50,Q04637,Q6Y7W6 7 +Natal tooth 0.2868852459016452 0.1106717479798993 0.9118766501694996 1.0 1.0 8 P14923,Q9H9B1,P21333,P15924,Q69YQ0,O14802,P02545 7 +Antiphospholipid antibody positivity 0.4717906786590469 0.1104142638814571 0.9120808413534348 1.0 1.0 2 P49327 1 +Abnormal fingertip morphology 0.2481541407510075 0.1101370799645161 0.9123006614630332 1.0 1.0 21 Q7LGA3,P55011,Q7Z6Z7,P26196,P41227,O75648,Q86TI2,Q9Y296,O14646 9 +Craniofacial hyperostosis 0.4560327198364059 0.1101303617125026 0.9123059894417188 1.0 1.0 3 P21333,P51812 2 +Mildly elevated creatine kinase 0.2533820933532871 0.1081998207563857 0.9138371871378967 1.0 1.0 18 Q9BUK6,Q92734,O75648,O75340 4 +Truncus arteriosus 0.2726527265272681 0.1081537616000425 0.91387372262786 1.0 1.0 9 P21964,Q8TD19,P53992,O00232,Q92890,P28482,Q9UHX1,Q92766 8 +Thoracic hypoplasia 0.2471874396881366 0.1056978895317424 0.9158220548819248 1.0 1.0 24 Q15436,P41227,Q9Y281 3 +Delayed ability to walk 0.2326977662085811 0.1043694199317763 0.9168761894791292 1.0 1.0 56 Q99720,O43776,Q13409,P55011,P61978,Q7Z6Z7,P35637,Q8N3U4,Q92785,Q7L2E3,Q03252,P57081,O75648,Q15042,Q9UQ13,P11233,P35609,Q01105 18 +Abnormal growth hormone level 0.2460043167305683 0.1025182983319369 0.918345289401681 1.0 1.0 21 Q7Z2Z2,Q8N3U4,Q15813,Q07864,P57081,Q9Y3A5,Q12824,Q9NVI1 8 +Increased sensitivity to ionizing radiation 0.4496459631937403 0.1016274580039619 0.9190523839469846 1.0 1.0 3 Q12824 1 +Cleft soft palate 0.234887054044657 0.1013311563164755 0.9192875843121512 1.0 1.0 50 P21281,P61978,Q15392,Q15813,O75312,Q9C0B1,P46777,Q15436,P36871 9 +Scapular winging 0.2446984262310695 0.1000278872930321 0.9203221856127932 1.0 1.0 20 O75340,P11047 2 +Excessive daytime somnolence 0.2633648923776011 0.0986489616995658 0.9214169937689892 1.0 1.0 10 P41227 1 +Skin dimple 0.2441170940492625 0.0980760745360509 0.9218718856726428 1.0 1.0 20 Q13363,Q08J23,Q9H3P2,P61978 4 +Patent foramen ovale 0.2451159518910704 0.0975371700581036 0.9222998175004256 1.0 1.0 23 Q96AX1,Q9NVI1,O15047,P43897 4 +Large basal ganglia 0.2560298116938419 0.094163164360855 0.9249795453020396 1.0 1.0 13 P15311,Q9ULK4,Q08J23,P55011 4 +Thin skin 0.250365758535335 0.0924834700773262 0.9263139238986984 1.0 1.0 17 Q9H4L7 1 +Angiofibromas 0.4418954475179159 0.0919350386106118 0.9267496525485204 1.0 1.0 3 P43246 1 +Adenoma sebaceum 0.4418954475179159 0.0919350386106118 0.9267496525485204 1.0 1.0 3 P43246 1 +Abnormal tricuspid valve morphology 0.2642912906725658 0.0913268513776528 0.9272328828238414 1.0 1.0 9 Q92766 1 +Aplasia hypoplasia of the optic nerve 0.2529641685889207 0.0910077028429113 0.9274864704750748 1.0 1.0 15 P61978,Q8N3U4,Q8WXI9,O75312,Q9NVI1 5 +Cor pulmonale 0.4562551103843095 0.0902804297750149 0.9280643714141724 1.0 1.0 2 P21333 1 +Severe infection 0.3173070683363166 0.0895724996853358 0.928626938610758 1.0 1.0 5 P17812 1 +Peripheral axonal neuropathy 0.2353811668228761 0.0885069980219615 0.9294737225516752 1.0 1.0 39 P04792 1 +Vertebral segmentation defect 0.2425228268403283 0.0881971234813614 0.929720003538729 1.0 1.0 23 Q13363,P21281,P61978,Q6DKJ4,Q9NVI1 5 +Supernumerary tooth 0.2959288506153225 0.0877963922132754 0.9300385052902488 1.0 1.0 6 P21281,Q6DKJ4,Q9UBM7 3 +Abnormal sclera morphology 0.2416569649206059 0.087683957950916 0.9301278702086851 1.0 1.0 21 Q9UN37,Q96EK5,Q9H3U1,O75718,Q96AY3 5 +Branchial cyst 0.4538021259198809 0.0873768941611799 0.9303719349115642 1.0 1.0 2 Q9UHX1 1 +Cleft upper lip 0.2420398609137792 0.0871468555411955 0.930554781691782 1.0 1.0 25 Q13363,Q8N3U4,P41227,Q9H9Y6,Q9H3P2,P46777,P39019 7 +Abnormality of dental structure 0.2297702433580085 0.0865033177157066 0.9310663188040804 1.0 1.0 56 P61586,Q96AY3,Q5JRA6 3 +Stage 5 chronic kidney disease 0.242062690725477 0.0864737367432823 0.931089832894782 1.0 1.0 24 P07741,P11047,P52565,Q9P2R3,Q9NQW6,Q8NFH4,O95470,Q9NPF4,Q9Y5K6 9 +Entropion 0.2867677181482981 0.0861743691130315 0.9313278053834926 1.0 1.0 7 P01889,P18074,P38606,O14802,P30153,P02545 6 +Short thumb 0.238334394484502 0.0860744336992632 0.9314072471340484 1.0 1.0 36 Q13363,P21281,Q03252,Q9BXW9,Q9H3P2,P46777 6 +Central hypothyroidism 0.2733606557377127 0.0848446722472308 0.9323848782387528 1.0 1.0 8 Q8N3U4,O00170,Q9NW13,Q12824,P35222,P27635,O14654 7 +Lower limb metaphyseal irregularity 0.4323108384458061 0.0808812558113972 0.9355363868158608 1.0 1.0 3 Q9Y3A5,P26373 2 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.3469721767594098 0.0807175663008719 0.935666566512618 1.0 1.0 4 P50402,Q9BTV4,Q15149 3 +Limitation of knee mobility 0.4319018404908007 0.0804321290039295 0.935893574424391 1.0 1.0 3 Q14315,P21333 2 +Abnormal peripheral nervous system morphology 0.213408149830394 0.079624454908907 0.9365359447612084 1.0 1.0 111 Q92734,P04792,Q14203,P51530,P23381,Q16637,O75340,Q9NR77,Q99720,Q9Y281,P41440,P07384,O95831,Q9BUF5,Q6DKK2,P35637,Q13148,P11047,P40763 19 +Chondrocalcinosis 0.4308384054888113 0.0792729010116631 0.9368155603130308 1.0 1.0 3 P53680 1 +Prominent nasal bridge 0.2347474679041352 0.0788301023800614 0.9371677603072948 1.0 1.0 38 Q9Y2U8,Q15436,Q9BW83,Q96EK5,Q08J23,Q92766,Q5JRA6 7 +Motor axonal neuropathy 0.2472252618066254 0.0754839316452321 0.9398296817496332 1.0 1.0 11 O95831,P23381 2 +Prematurely aged appearance 0.2386413512455261 0.07537380737006 0.939917298604978 1.0 1.0 30 Q03252,P41227,Q15042,Q13126 4 +Thickened helices 0.2880549879916319 0.0753577641352339 0.9399300629520696 1.0 1.0 6 Q96S52,P06400,Q06124 3 +Abnormality of the diaphragm 0.2383507070728174 0.0750123215129257 0.94020490836506 1.0 1.0 22 Q13363,O60568 2 +Polydactyly 0.235810659361601 0.0741153986282892 0.9409185626265552 1.0 1.0 36 Q13363,Q9BW83,Q9BXW9,P98175,Q9H3P2,Q92766 6 +Lymphopenia 0.2391273726308136 0.0733921052991539 0.941494099713283 1.0 1.0 19 P50851,O95394,P26038,P00491,Q96MG7,P28070,O95470,P17812 8 +Delayed menarche 0.2866502866502821 0.0732537945310986 0.9416041594869122 1.0 1.0 6 Q06124,O00429,P02545,Q9UJS0,Q9UNE7 5 +Aplasia hypoplasia affecting the anterior segment of the eye 0.2377430671833323 0.0730322771150444 0.9417804326593112 1.0 1.0 22 Q13363,Q15645,P11047,Q9BXW9,Q13263,Q9NVI1 6 +Myopathic facies 0.305061840199897 0.071875441088247 0.9427010346607632 1.0 1.0 5 Q9BUK6,Q00577 2 +Abnormality of the forearm 0.2358810410135441 0.0708529831853477 0.9435147632605744 1.0 1.0 35 Q96AY3 1 +Aplasia hypoplasia of the 4th metacarpal 0.4208588957055204 0.0689879699004668 0.9449991953131872 1.0 1.0 3 Q96S52,P21333 2 +Abnormality of the 4th metacarpal 0.4208588957055204 0.0689879699004668 0.9449991953131872 1.0 1.0 3 Q96S52,P21333 2 +Abnormal rib ossification 0.4208588957055181 0.0689879699004645 0.9449991953131888 1.0 1.0 3 Q9Y3A5,P61011 2 +Multiple prenatal fractures 0.2825132489457613 0.0672575865209867 0.946376641447473 1.0 1.0 6 Q15650,O75718 2 +Abnormality of the nasal bone 0.4155419222903849 0.0639372872623026 0.9490201620627554 1.0 1.0 3 P10644,Q6NUK1 2 +Abnormal ureter morphology 0.2412753572347954 0.0638781476625194 0.9490672523750528 1.0 1.0 15 Q9BXW9,P41227,Q9NVI1 3 +Absent toenail 0.272429332240883 0.0634687101065441 0.949393274709903 1.0 1.0 7 P21281,P14923,Q14739,P15924,O14497,P28482 6 +Ankyloglossia 0.2724293322408797 0.0634687101065391 0.949393274709907 1.0 1.0 7 Q01082,Q6DKJ4,Q9Y4R8,O75844,P28482,P02545 6 +Exertional dyspnea 0.2400269951233124 0.0632608568700989 0.9495587849943083 1.0 1.0 16 P40763,P11047,Q86TI2 3 +Spastic paraparetic gait 0.4296811120196331 0.0626255550178146 0.9500646793938208 1.0 1.0 2 Q12756 1 +Secundum atrial septal defect 0.4130879345603225 0.061704328136401 0.9507982931853332 1.0 1.0 3 Q15650,P34897 2 +Generalized limb muscle atrophy 0.2780507780507729 0.0611216414609783 0.9512623339776504 1.0 1.0 6 Q9Y2Z4,Q9Y2U8,P06753,P49589,Q9Y606 5 +Increased hepatic glycogen content 0.4110195709024181 0.0598696722124638 0.9522594346194552 1.0 1.0 3 P36871 1 +Deviation of the hand or of fingers of the hand 0.2201361203184278 0.0586605350343158 0.9532224936598296 1.0 1.0 82 P21281,Q15645,Q9Y2U8,P41227,Q03252,O60828,P57081,Q9BXW9,Q8NFH4,Q15042,Q9NVI1,P83436,Q5JRA6,Q06124 14 +Neoplasm of the pancreas 0.2309347465624024 0.0574360374737316 0.9541978566189996 1.0 1.0 20 Q8WX93,P43246,Q01844 3 +Mild short stature 0.420686835650054 0.0550650784793836 0.956086617250608 1.0 1.0 2 P10644 1 +Diaphyseal thickening 0.4206868356500509 0.0550650784793811 0.95608661725061 1.0 1.0 2 P08236 1 +Severe short limb dwarfism 0.4206868356500483 0.0550650784793788 0.9560866172506116 1.0 1.0 2 O75369 1 +Absent or minimally ossified vertebral bodies 0.4206868356500483 0.0550650784793788 0.9560866172506116 1.0 1.0 2 O75369 1 +Abnormally ossified vertebrae 0.4206868356500483 0.0550650784793788 0.9560866172506116 1.0 1.0 2 O75369 1 +Relative macrocephaly 0.2326273343965617 0.0537031283261722 0.9571716903568772 1.0 1.0 28 Q7LGA3,P55011,P26196,Q6DKJ4,Q15392,Q07864,O75648,Q9Y296,Q9UQ13,Q96J02 10 +Fractures of the long bones 0.3220057743122875 0.0526090350277573 0.9580434180306124 1.0 1.0 4 Q13126 1 +Macule 0.2255788636826306 0.0523311763690797 0.9582648121924277 1.0 1.0 52 Q15645,Q9H4L7,P26196,O75648,Q9BXW9,Q06136,Q9Y296,Q9UQ13,P43246,Q9NVI1,Q06124 11 +Renal hypoplasia 0.2317672016333257 0.0508967998068823 0.9594077555908016 1.0 1.0 25 Q9Y2U8,P41227,O60828,O75312,Q92766 5 +Vitreous hemorrhage 0.3995910020449867 0.0504937783879916 0.9597289072093628 1.0 1.0 3 P06400,P35222 2 +Corneal ulceration 0.2865329512893996 0.0495382823817039 0.960490329707372 1.0 1.0 5 O95163,P06132,Q96EK5,P02545 4 +Bird like facies 0.2865329512893995 0.0495382823817036 0.960490329707372 1.0 1.0 5 P26639,P18074,Q92878,P02545 4 +Absence of subcutaneous fat 0.2865329512893995 0.0495382823817036 0.960490329707372 1.0 1.0 5 P26639,P18074,O14802,P02545 4 +Wide nasal bridge 0.2152543723452253 0.0480955686430015 0.9616400778311244 1.0 1.0 128 P41227,O60828,O75648,P98175,Q9H3P2,Q08J23,P61586,Q01105,Q06124,Q13363,O75340,Q15555,P26196,Q96EK5,Q9Y296,O95602,P52732,P55011,P61978,Q9UNW1,Q15042,Q92766,P21281,Q8WXI9,P40763,P46777,Q96AX1,Q15436 28 +Aplasia hypoplasia of the lungs 0.2304230934955894 0.0476618190735085 0.9619857634664404 1.0 1.0 27 Q13363,P41227 2 +Metaphyseal irregularity 0.2487704918032837 0.0474713802983282 0.9621375398243636 1.0 1.0 8 Q7Z2Z2,Q9NR45,Q14807,P26373,P61011,Q9NSE4,Q9Y3A5 7 +Scarring 0.2283847196830808 0.0471859626211369 0.962365015266025 1.0 1.0 21 Q8WWY3,P61586,Q9Y2U8,Q15555 4 +Abnormal hair whorl 0.2316707403460272 0.0456867754349239 0.9635599044776004 1.0 1.0 16 Q7LGA3,Q7Z6Z7,P55011,P26196,O75648,Q9Y296,P09884 7 +Happy demeanor 0.4071954210956767 0.0452754598578703 0.9638877475714568 1.0 1.0 2 P30566 1 +Proximal muscle weakness in lower limbs 0.2269323777611662 0.0411003881923398 0.96721586513384 1.0 1.0 11 Q16637,P50570 2 +Intestinal atresia 0.2302742084658491 0.0388484339264768 0.9690112292677052 1.0 1.0 9 Q15645,Q8N3U4,Q7LBC6,O43683,O43684 5 +Peters anomaly 0.3945216680294419 0.0376369460274432 0.969977150109374 1.0 1.0 2 Q12948 1 +Tics 0.2722063037249298 0.0357110685721283 0.9715127447383134 1.0 1.0 5 Q8WXI9,Q01082,P28482,Q9UHX1 4 +Pelvic kidney 0.2387166773559293 0.0355722910154467 0.971623402899606 1.0 1.0 8 Q9BXW9 1 +Velopharyngeal insufficiency 0.3752241146894149 0.0345046972352867 0.9724746967281372 1.0 1.0 3 Q9BUF5 1 +Stomatitis 0.2214158389486473 0.0334848749043908 0.973287927146685 1.0 1.0 11 Q6UN15,P40763 2 +Phocomelia 0.3863450531480072 0.0334368503905021 0.973326223719868 1.0 1.0 2 Q15427 1 +Glossoptosis 0.2528136410415223 0.0326164178687374 0.9739804772301984 1.0 1.0 6 P98175 1 +Abnormality of the pancreas 0.2157050567171084 0.0321212885143261 0.9743753263893078 1.0 1.0 62 Q8WX93,P14174,Q15904,Q9BXW9,P40763,Q01844 6 +Retinal telangiectasia 0.2966448445171867 0.0319714881986463 0.9744947883905228 1.0 1.0 4 O75306,Q14331,P35222 3 +Abnormality of the fontanelles or cranial sutures 0.2144401070842684 0.0310506088299247 0.9752291790995042 1.0 1.0 76 P21281,Q9Y2U8,P61978,P26196,P41227,Q15813,Q15436,O95831,P09884,P98175,Q08J23,P40763,O75718,Q96AY3,Q92766,O15047 16 +Aplasia hypoplasia of the spleen 0.3686067615733709 0.0310162342474174 0.9752565928442684 1.0 1.0 3 Q86Y56 1 +Dimple chin 0.3744889615699172 0.0282611159683302 0.9774538931653032 1.0 1.0 2 Q2VPK5 1 +Laryngeal cleft 0.3744889615699176 0.0282611159683302 0.9774538931653032 1.0 1.0 2 Q01082 1 +Abnormal circulating amylase level 0.262382316823579 0.0278268259674918 0.9778002702157846 1.0 1.0 5 A5YKK6,Q7Z2Z2,Q9Y3A5,P61011 4 +Abnormal pancreas morphology 0.220808908291362 0.0269771571635821 0.9784779533424026 1.0 1.0 14 Q9BXW9 1 +Abnormality of muscle size 0.2254885167091093 0.0264554313428949 0.9788940817804844 1.0 1.0 155 Q92734,P04792,Q14203,P51530,O60828,Q16637,Q9BUK6,Q9BW83,O14979,O00400,O60568,Q9NR77,Q99720,Q9Y2U8,Q9H9B1,Q9UNW1,P07384,O95831,Q9C0B1,P83436,Q13126,Q6DKK2,P21281,P35637,Q13148,Q15813,P11047,Q03252,P55263,Q96AX1,Q92804 31 +Microvesicular hepatic steatosis 0.2295054678249025 0.0262623444058458 0.9790480893553792 1.0 1.0 8 O75648,Q9H3U1 2 +Transposition of the great arteries 0.2864157119476285 0.0256368560670058 0.9795469888325888 1.0 1.0 4 O43175,Q86Y56,P02545 3 +Short lingual frenulum 0.2864157119476265 0.0256368560670047 0.9795469888325896 1.0 1.0 4 P21281,Q69YQ0,P02545 3 +Progressive external ophthalmoplegia 0.2444227671886795 0.0253160385472496 0.9798028811205002 1.0 1.0 6 P51530 1 +Abnormal ileum morphology 0.2145002245543252 0.0249217301991569 0.9801173944235516 1.0 1.0 11 Q9BXW9 1 +Branchial anomaly 0.2270491803278725 0.0240236335939228 0.980833757263579 1.0 1.0 8 P61978,Q9H9Y6,P28482,P46109,Q9UHX1,P27635,Q13428 7 +Aplasia hypoplasia of the thumb 0.2192898899557484 0.0235481632222306 0.9812130204258604 1.0 1.0 41 Q13363,P21281,Q03252,Q9BXW9,Q9H3P2,P46777,Q9NVI1 7 +Mesomelia 0.255423659435122 0.0229696384667113 0.9816744915505052 1.0 1.0 5 Q6DKJ4,Q14739,P21333,Q9UBM7 4 +Generalized osteoporosis 0.3468302658486679 0.021759636577081 0.9826396919022168 1.0 1.0 3 Q6P1J9,P42224 2 +Congenital contracture 0.2245223296027049 0.0213045137475876 0.9830027432074644 1.0 1.0 33 Q96AY3,Q15392,Q9Y281 3 +Contractures of the joints of the lower limbs 0.2194494866330035 0.0212946438284909 0.9830106164773842 1.0 1.0 43 O75340,Q99720,Q96AY3,P35637 4 +Gastrointestinal atresia 0.2151428053960555 0.0208347029730953 0.983377514772382 1.0 1.0 13 Q15645,Q8N3U4,Q9BXW9,Q15149,O43683,O43684 6 +Short philtrum 0.2188327121992698 0.0197434849524457 0.9842480015551268 1.0 1.0 53 Q13363,Q7Z6Z7,Q6DKJ4,Q92785,O60828,P57081,Q96EK5,Q8WXI9,Q9H3P2,Q08J23,Q15042,P60953,Q92766,P11233,Q96J02 15 +Severe photosensitivity 0.3454619787408085 0.0194107857902942 0.984513406213846 1.0 1.0 2 Q9UBM7 1 +Bone spicule pigmentation of the retina 0.2364534301262202 0.0192934175669972 0.9846070349732834 1.0 1.0 6 Q15555 1 +Sleep wake cycle disturbance 0.2729132569558122 0.0187997709011407 0.9850008365857384 1.0 1.0 4 Q8N3U4,Q9UBM7,Q9Y4R8 3 +Semilobar holoprosencephaly 0.2729132569558103 0.0187997709011399 0.985000836585739 1.0 1.0 4 A5YKK6,O94979,Q8N3U4 3 +Upslanted palpebral fissure 0.2084665184890322 0.0178681699206052 0.9857440216825046 1.0 1.0 68 Q7LGA3,O60828,Q15555,Q6DKJ4,P52732,P35606,Q9H9B1,Q9BTW9,Q9UNW1,Q86XL3,P60953,P09884,P83436,Q92766,O43776,Q13409,Q8WXI9,Q9BXW9,Q9NVI1 19 +Long ear 0.3352412101390108 0.0173322948073313 0.9861715219386742 1.0 1.0 2 Q7LBC6 1 +Upper limb muscle weakness 0.2144447921432712 0.0168479622073703 0.986557907008355 1.0 1.0 15 Q8N0X7,Q92734,Q12824 3 +Narrow palpebral fissure 0.2115388370427847 0.0164332401044593 0.9868887615573478 1.0 1.0 13 O95394,P38159,P26196,O75648,Q8WXI9 5 +Abnormal dermoepidermal junction morphology 0.3288343558282161 0.0163151355527429 0.9869829827238132 1.0 1.0 3 P14923,Q15149 2 +Premature skin wrinkling 0.2140419574380193 0.0162947778356959 0.9869992236729532 1.0 1.0 15 P41227 1 +Mild postnatal growth retardation 0.3229762878168518 0.0153884745625205 0.9877222583062456 1.0 1.0 2 P10644 1 +Abnormal lung development 0.2195993898173148 0.0148339453250658 0.9881646581040712 1.0 1.0 39 Q13363,Q15645,P41227,Q9H3P2,Q92766 5 +Neoplasm of the larynx 0.2630916318936396 0.0147979553849856 0.988193370770038 1.0 1.0 4 P43246 1 +Horizontal eyebrow 0.3222903885480538 0.0147484000729903 0.988232905873941 1.0 1.0 3 Q16531,P11233 2 +Macrocytic anemia 0.2224623604737222 0.0140364632047119 0.9888008904676088 1.0 1.0 32 P18077,Q7Z2Z2,P62244,P41440,Q99707,P00374,P42766,P11172,Q9Y3A5,P11586,P46777,P39019 12 +Abnormal blood chloride concentration 0.3115290269828372 0.014021575080169 0.9888127683034048 1.0 1.0 2 Q9UNF1 1 +Abnormal thoracic spine morphology 0.2177379604015412 0.0136063519395276 0.9891440368254678 1.0 1.0 23 Q96AX1,O95831,Q96J02 3 +Lower eyelid coloboma 0.2592901155330478 0.0134466146141308 0.9892714771119132 1.0 1.0 4 Q9H9Y6 1 +Recurrent pancreatitis 0.3045789043336142 0.0133659493357428 0.9893358329085726 1.0 1.0 2 Q6P1J9 1 +Broad philtrum 0.2025420254202572 0.0131209456774975 0.9895313004021716 1.0 1.0 9 P51532,Q01082,Q92785,O14497,Q96CW1,Q12824,Q9UM00,Q8TAQ2 8 +Synostosis involving bones of the upper limbs 0.2180426542292468 0.0119392966641275 0.9904740458411064 1.0 1.0 24 Q13363,O60828 2 +Cyclopia 0.2726901062960029 0.0115638218098785 0.9907736107429794 1.0 1.0 2 Q8N3U4 1 +Median cleft lip 0.2726901062960029 0.0115638218098785 0.9907736107429794 1.0 1.0 2 Q8N3U4 1 +Panhypopituitarism 0.2726901062960029 0.0115638218098785 0.9907736107429794 1.0 1.0 2 Q8N3U4 1 +Abnormal dura mater morphology 0.2726901062960029 0.0115638218098785 0.9907736107429794 1.0 1.0 2 Q8N3U4 1 +Congenital hypothyroidism 0.3049443013773235 0.0114798053269198 0.9908406417481614 1.0 1.0 3 P21281 1 +Food allergy 0.2504091653027833 0.0106796936601869 0.9914789992930796 1.0 1.0 4 Q01082,O95394,Q9Y5S9 3 +Hypopigmented macule 0.2957055214723862 0.0101834773172854 0.9918749011066345 1.0 1.0 3 Q15149,Q15233 2 +Abnormal cell morphology 0.2789366053169659 0.0084512675234451 0.9932569443931712 1.0 1.0 3 P15924,P35609 2 +Single naris 0.2728016359918123 0.0079815592232784 0.9936317047403644 1.0 1.0 3 Q8N3U4,A6NHR9 2 +Abnormal morphology of the olfactory bulb 0.2728016359918123 0.0079815592232784 0.9936317047403644 1.0 1.0 3 Q8N3U4,A6NHR9 2 +Solitary median maxillary central incisor 0.272801635991812 0.0079815592232784 0.9936317047403644 1.0 1.0 3 A5YKK6,Q8N3U4 2 +Agenesis of corpus callosum 0.2101678596889384 0.0077870948605374 0.9937868600302732 1.0 1.0 63 Q7LGA3,Q9H3P2,Q12824,Q13363,Q92785,Q15392,P57081,Q9Y3C6,P35606,Q9H9B1,P55011,P61978,Q86XL3,Q15042,P26639,Q69YN2,Q13409,Q8N3U4,Q9BXW9,Q00535,Q9NVI1 21 +Cavernous hemangioma 0.2476966113998898 0.006720620406413 0.9946377611045438 1.0 1.0 3 P50570 1 +Cytochrome c oxidase negative muscle fibers 0.2179798798972332 0.0055312446135224 0.9955867278246232 1.0 1.0 5 O75648 1 +Abnormality of dental morphology 0.2158133478782747 0.0042795020026995 0.9965854618465112 1.0 1.0 52 P21281,Q15555,P26196,P41227,O60828,P57081,O75648,Q9Y296,P61586,Q15436 10 +Slender build 0.1921503244053167 0.0040539419423932 0.9967654311734996 1.0 1.0 11 P10644,P51530,P17612 3 +Abnormal nasal base 0.1877940445333735 0.0024926557023903 0.9980111505592296 1.0 1.0 10 P21281,Q12824 2 +Hypoplastic fifth fingernail 0.2022932022931974 0.0020024423934893 0.9984022831980854 1.0 1.0 6 P51532,Q92785,O14497,Q12824,Q8TAQ2 5 +Abnormal corneal epithelium morphology 0.2000671252791309 0.0018359550029409 0.998535120671777 1.0 1.0 14 P50747,P26639,Q15149,Q96EK5 4 +Hypoplastic fifth toenail 0.202376075378943 0.0016937680212281 0.9986485692924558 1.0 1.0 7 P51532,Q92785,O14497,Q14738,Q12824,Q8TAQ2 6 +Prominent eyelashes 0.2023760753789417 0.0016937680212278 0.998648569292456 1.0 1.0 7 P51532,Q92785,O14497,Q12824,P20700,Q8TAQ2 6 +Abnormality of malar bones 0.2150183154521401 0.0007073367133046 0.9994356270042268 1.0 1.0 52 Q9H9B1,O60828,O95831,O60568,Q15042,P61586,Q15436 7 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a7dfdeae9ea54b2c5565d9e5a86bfe38fd0e8759 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal coronary sinus morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the eustachian tube", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hypertrichosis", "Facial hypotonia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked horizontal nystagmus", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic ilia", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Left atrial enlargement", "Left bundle branch block", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lenticonus", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited wrist extension", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular degeneration", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Malar rash", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ANAPC1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOC3", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARPC1B", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATXN10", "AURKA", "B4GAT1", "BANF1", "BAX", "BAZ1B", "BCAP31", "BCAT2", "BICD2", "BLM", "BLVRA", "BMS1", "BPTF", "BRCA1", "BRD4", "BUB1", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CAD", "CALD1", "CALM3", "CALR", "CAPN1", "CARS", "CAST", "CBFB", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDH2", "CDK4", "CDK5", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHORDC1", "CISD2", "CLASP1", "CLCC1", "CLCN7", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNOT1", "CNP", "COA7", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTU2", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "DARS", "DARS2", "DBT", "DCAF8", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "ERAL1", "ERCC2", "ERGIC1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FDXR", "FH", "FIP1L1", "FKBP10", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FRG1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GAMT", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GCDH", "GCLC", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLS", "GLUD1", "GNAI3", "GNPAT", "GNS", "GOT2", "GPD2", "GPHN", "GPI", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2BP2", "IGF2R", "IRS4", "ITCH", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "L2HGDH", "LAMC1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD3", "LETM1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPAP1", "LRPPRC", "LSS", "MACF1", "MAGED2", "MAN2B1", "MAP2K1", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED23", "MIA3", "MIF", "MINPP1", "MIPEP", "MMAB", "MOGS", "MPDU1", "MPI", "MRE11", "MRPL12", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH6", "MSN", "MSTO1", "MTAP", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVD", "MYH9", "MYO6", "NAA10", "NAA15", 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6.290791570409542 1.0118856061679289 1.2857516091435552 0.3675316845524202 1.0 1.0 0.0002023807035819 1.7937387891180026e-05 1.0241041174398885e-08 +Glutathione metabolism 2 20 2.452335512598072 0.0141932253700836 6.274271844660194 21.08009708737864 -0.1122831947242248 0.4562342423885884 3.327586694235611 1.6118167974780178 1.1803082775568734 0.3251823709550127 1.0 0.0036908164949181 0.0227243730256059 0.029242664933406 0.0026127393686239 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b737f9f55637fdc89bbb26336636b50f1f446ec7 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 178, + "title": "Average number of proteins per term", + "value": 13.438202247191011 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d6ade3f9125594e10244b9d4f408ed736d211fba --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..703dcdbbdc81d486ff2fea4f44f4b3a87dabdb80 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,70 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome 0.5988593644201523 2.850015205197769 0.0043717139108014 0.5415348538874974 0.0794675273440188 35 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Glutathione metabolism 0.6308309588215815 2.4523355125980717 0.0141932253700836 0.921487264242146 0.1662025450217616 20 P48735,O75874 2 +Vibrio cholerae infection 0.5665838263276642 1.8024727417503876 0.0714710595558965 0.9999981482212176 0.4747209782907395 17 Q15904 1 +Jak stat signaling pathway 0.85441516458168 1.8005343805842482 0.0717762999348012 0.9999982534853892 0.4747209782907395 4 P40763,Q06124 2 +Tight junction 0.4869771268380908 1.7817348146092429 0.0747924867017211 0.9999990214819184 0.4747209782907395 28 P35579,Q9Y624,P16989,Q14247,Q9UDY2,P35580,P63151,P60953,P11802,P61586,P35609,P30153 12 +Mismatch repair 0.5735697076879154 1.664168718721785 0.0960787174129365 0.99999998446723 0.5173955785264195 14 Q9UQ84,P15927,P41440 3 +Endocytosis 0.4309527062262818 1.6364995219840452 0.1017350856653072 0.9999999949185256 0.5173955785264195 38 P42566,O43633,P09497,Q9H4M9,Q99816,P20339,Q9UN37,Q8N6T3,Q9H223,Q9H3U1,P50570,P54652,P53680,Q15075,Q96J02 15 +Tgf beta signaling pathway 0.5974375632638815 1.4867005101994146 0.1370939278997824 0.9999999999960052 0.5969373466020499 9 P63208,P61586,Q7Z3T8 3 +Peroxisome 0.4555844895577444 1.4563990010367596 0.1452823515646875 0.999999999999268 0.5969373466020499 25 P48735,P34913,O75874 3 +Wnt signaling pathway 0.4697774365179624 1.3463318209607524 0.1781955279197025 0.9999999999999992 0.6724519750824505 19 P61586 1 +Chemokine signaling pathway 0.5110796781491371 1.3145505130591997 0.1886610110282924 1.0 0.6724519750824505 14 P61586,P40763 2 +Arachidonic acid metabolism 0.6704252625340176 1.3138668854279352 0.1888910042366434 1.0 0.6724519750824505 5 P09960,P34913 2 +Pathways in cancer 0.3793339263728578 1.2194262202541928 0.2226824630820791 1.0 0.7130876608057554 39 Q13363,Q92734,P11047,P40763,Q16204,P61586,P43246 7 +Apoptosis 0.5027340598748953 1.1645536919524595 0.2441996977724541 1.0 0.7130876608057554 11 P10644,O00273,P07384,O95831,Q07812,P17655 6 +Fc gamma r mediated phagocytosis 0.4697418008355651 1.1632571924919848 0.2447251682041895 1.0 0.7130876608057554 16 P50570,Q9Y281,P60953,O15143,O15144,P59998,Q92747 7 +Prion diseases 0.5801310843308414 1.162639160217772 0.2449759354251419 1.0 0.7130876608057554 7 P31948,P11047,Q07812,P17612 4 +Ubiquitin mediated proteolysis 0.3898748302691029 1.160626147344315 0.2457939673108788 1.0 0.7130876608057554 34 Q9UBT2,P63208,Q16763,Q15386,Q9UJX4,Q9UJX2,P61081,Q8TBC4,A0AVT1,Q93034,Q96J02,Q14139 12 +Inositol phosphate metabolism 0.5971270281419179 1.1549554486110856 0.2481086709950113 1.0 0.7130876608057554 6 Q9UNW1 1 +Epithelial cell signaling in helicobacter pylori infection 0.4704553767972551 1.1241057497322446 0.260968166394993 1.0 0.7130876608057554 15 P21281,Q15904,Q06124 3 +Citrate cycle tca cycle 0.4153204002067634 1.1141630589986975 0.2652092400652308 1.0 0.7130876608057554 23 P48735 1 +Mapk signaling pathway 0.4043912016169873 1.1131688023683084 0.2656359387498339 1.0 0.7130876608057554 26 P51452,P04792,P62993,Q15418,P16949,P60953,P54652 7 +T cell receptor signaling pathway 0.482081281583027 1.055689318030347 0.2911101789981285 1.0 0.7130876608057554 11 P62993,P61586,P11802,P60953 4 +Leukocyte transendothelial migration 0.4306879325135543 1.033737860251784 0.3012587285294528 1.0 0.7130876608057554 18 P15311,Q9Y624,P26038,P18206,P60953,P61586,P35609,Q06124 8 +Chronic myeloid leukemia 0.4668724973879989 1.0316124469068302 0.3022537071511157 1.0 0.7130876608057554 13 Q13363,P62993,Q06124 3 +Colorectal cancer 0.4899673620978524 1.0245138274593857 0.3055926431096711 1.0 0.7130876608057554 10 P61586,P43246,Q07812 3 +Vasopressin regulated water reabsorption 0.4618633235795656 1.0041695404808764 0.3152969010660529 1.0 0.7130876608057554 13 Q13409,P20339,Q14203,P52565,Q9Y6G9,Q9UJW0 6 +Glycine serine and threonine metabolism 0.5175391328363681 0.9828813547706516 0.3256658354061144 1.0 0.7130876608057554 8 P34896 1 +Axon guidance 0.4310419120741212 0.9827113134809158 0.3257495409841513 1.0 0.7130876608057554 17 Q9Y281,Q13177,O14786,Q00535,P60953,P61586 6 +Dna replication 0.3905901234172559 0.9623669755116472 0.3358652964951014 1.0 0.7130876608057554 24 P27694,P33991,P41440,P49642,P51530,P39748,Q07864,P33993,P15927,P25205,P09884,Q5TBB1 12 +Selenoamino acid metabolism 0.5354319515053931 0.9610773482957696 0.3365132781330531 1.0 0.7130876608057554 7 Q9UJ14,O43252,P49903 3 +Focal adhesion 0.3778237021863069 0.9447840211160224 0.3447691512009587 1.0 0.7195205753478092 27 P62993,Q15942,P11047,Q13177,P60953,P61586,P35609,Q9Y490,P17655 9 +Viral myocarditis 0.5081798316095067 0.9391893492326892 0.3476335364039977 1.0 0.7195205753478092 8 P35579,Q04637,P78344 3 +Sulfur metabolism 0.7424366312346726 0.895055230515555 0.3707575644622203 1.0 0.7217446623653699 2 O95861 1 +Pathogenic escherichia coli infection 0.3857934170668805 0.8748478105369479 0.3816567190267772 1.0 0.7217446623653699 21 P15311,P60953,Q14247,O15143,O15144,Q9BUF5,P68371,P59998,P61586,Q92747 10 +Acute myeloid leukemia 0.5150623954594168 0.8702959470886978 0.3841386932411894 1.0 0.7217446623653699 7 P40763 1 +Drug metabolism other enzymes 0.4913069540203344 0.8609682168955328 0.3892555482419972 1.0 0.7217446623653699 8 P08236,P49915,Q9BZX2,P11172 4 +Thyroid cancer 0.4600994229562089 0.8145806630797878 0.4153123827613825 1.0 0.7344695307097335 9 Q92734 1 +Adherens junction 0.3782673547822633 0.8120733131818203 0.4167495651779949 1.0 0.7344695307097335 20 P61586 1 +Olfactory transduction 0.71013900245299 0.7716455188108163 0.4403244067535792 1.0 0.75448412938097 2 P0DP25 1 +Natural killer cell mediated cytotoxicity 0.437113109089484 0.7605524727886962 0.4469244164693233 1.0 0.75448412938097 10 Q06124 1 +Phosphatidylinositol signaling system 0.5361458356276518 0.7544769659023731 0.4505628714683181 1.0 0.75448412938097 5 Q9UBF8 1 +Mtor signaling pathway 0.4434096626392577 0.7355319940149868 0.4620155623737401 1.0 0.75448412938097 9 Q9Y376,P23588,Q15418 3 +Pentose phosphate pathway 0.3997907319272841 0.6958500755127809 0.4865227254457438 1.0 0.7555052638159867 14 Q96G03,P11413,P36871 3 +Arginine and proline metabolism 0.3507560718281684 0.6573605018162862 0.510949142476864 1.0 0.7723519977616122 22 O15460,P30837 2 +Regulation of actin cytoskeleton 0.3178901004005514 0.655713272064698 0.5120086277296081 1.0 0.7723519977616122 38 P35579,P15311,Q9UQB8,Q9Y281,P60953,P35241,P35580,Q13177,O15143,O15144,P59998,P61586,P35609,Q92747 14 +Neurotrophin signaling pathway 0.3320324723683388 0.5763057138364462 0.564408561444437 1.0 0.8317118000365833 25 Q04917,P62993,P52565,Q07812,P0DP25,Q15418,P61586,Q06124 8 +Glioma 0.4029581870705317 0.5513442628909972 0.5813977012170524 1.0 0.8482687771855354 9 P62993,P0DP25 2 +Pancreatic cancer 0.3877448016989929 0.5280335762860024 0.5974760318798047 1.0 0.8485976276801147 10 P40763,P06400,P60953,P11802,P11233 5 +One carbon pool by folate 0.383768106587729 0.5102769209147751 0.6098574692016807 1.0 0.8485976276801147 10 P34896 1 +Progesterone mediated oocyte maturation 0.3367636954537543 0.5097487317245798 0.610227507545251 1.0 0.8485976276801147 19 P14635,P06493,P30260,Q9UJX4,Q9UJX2,Q15418,O43683 7 +Cysteine and methionine metabolism 0.3687875846786035 0.5009110809505708 0.6164337036125349 1.0 0.850582939868459 12 Q99707,P00338,Q13126 3 +Vascular smooth muscle contraction 0.3569542769213515 0.4464328474931773 0.6552846099342307 1.0 0.8836413679416141 12 P61586 1 +Amyotrophic lateral sclerosis als 0.3920443939023456 0.4316911949844331 0.665965867752129 1.0 0.8912926651118718 8 P20339,P07197,Q9BUN8 3 +Oocyte meiosis 0.2899537978841306 0.3785236483435591 0.7050416295095294 1.0 0.9069360831158744 34 P14635,P30260,P61981,Q04917,P06493,Q02750,P17612,P63208,Q9UJX4,Q9UJX2,P0DP25,P63104,Q15418,O43683,P30153 15 +Melanogenesis 0.3778688524590232 0.3778077440457982 0.7055734204684947 1.0 0.9069360831158744 8 P27361,P08754,P17612,Q02750,P0DP25,P35222,P49841 7 +Regulation of autophagy 0.5797408147519022 0.3665847122905082 0.7139288133427313 1.0 0.9069360831158744 3 Q9NT62 1 +Nucleotide excision repair 0.3261352876382829 0.350473767410538 0.7259831738441291 1.0 0.9069360831158744 15 P15927,P41440 2 +P53 signaling pathway 0.3507169701159344 0.2826037147478735 0.7774806324130745 1.0 0.9118626230822322 8 P11802,P14635,P31350,Q07812 4 +Cell cycle 0.2637789618046439 0.2733910246893972 0.7845526513514969 1.0 0.9118626230822322 40 P14635,P30260,P06493,Q04917,P33991,P63208,Q8N3U4,P11802,Q13547,Q9UJX4,P06400,P33993,P63104,Q9UJX2,P25205,O43683,O43684 17 +Gnrh signaling pathway 0.3408156842565848 0.2508561310744832 0.8019253423824566 1.0 0.9209207157682404 8 P62993,P0DP25,P17612,P60953 4 +Protein export 0.2918288813456822 0.2024689905679308 0.839550098310824 1.0 0.9356625980933304 14 P61009,O76094 2 +Hedgehog signaling pathway 0.5080469224522756 0.1971282688432925 0.8437271621060591 1.0 0.9356625980933304 3 P17612 1 +Starch and sucrose metabolism 0.2916681279821728 0.1955544353086437 0.8449589269455151 1.0 0.9356625980933304 13 Q8NBZ7,Q96G03,P13807,P36871 4 +Rig i like receptor signaling pathway 0.3703551692173115 0.194395495601963 0.8458662166376536 1.0 0.9356625980933304 5 Q13526 1 +Non small cell lung cancer 0.3099805549711443 0.1312416505024534 0.8955841485493232 1.0 0.9515101817941886 7 P62993,P06400,P11802 3 +Small cell lung cancer 0.3411213471117262 0.1309580304088418 0.8958085082799636 1.0 0.9515101817941886 5 P11047 1 +Non homologous end joining 0.3177723177723143 0.1281193115277364 0.8980545536035038 1.0 0.9515101817941886 6 P12956,P39748,P13010,Q92878,P78527 5 +Erbb signaling pathway 0.2755716487374614 0.0888065332941187 0.9292356653915664 1.0 0.9618519605718728 8 P62993,Q13177 2 +Adipocytokine signaling pathway 0.2453111262503542 0.0643866945150287 0.948662324282208 1.0 0.9618519605718728 10 P54619,P40763,Q06124 3 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d447b340534d0449d72982c0a05d1dec324d919b --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Taurine and hypotaurine metabolism", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADH5", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AIFM1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ANAPC1", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "APOC3", "APP", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "AURKA", "B4GAT1", "BAIAP2", "BAX", "BCAS2", "BCAT2", "BDH2", "BIRC6", "BLM", "BLVRA", "BPNT1", "BRCA1", "BUB1", "BUB1B", "BUB3", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CANX", "CAPN1", "CAPN2", "CARS", "CBR1", "CCDC6", "CCNB1", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDK1", "CDK4", "CDK5", "CDS2", "CFL1", "CFL2", "CHEK2", "CHERP", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT9", "COMT", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBT", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX8", "DIAPH1", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNA2", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPM1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERCC2", "ERO1A", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLC", "GFPT1", "GGA2", "GGCT", "GGH", "GGT7", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPD2", "GPI", "GRB2", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HDAC1", "HDAC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "IMPDH2", "IQGAP1", "IQGAP2", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LGMN", "LIG3", "LIPA", "LMNA", "LNPEP", "LPCAT1", "LSM2", "LSM6", "LSS", "LTA4H", "LYPLA1", "LYPLA2", "M6PR", "MAN2B1", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MGST2", "MGST3", "MIF", "MINPP1", "MMAB", "MOGS", "MPHOSPH6", "MPI", "MPST", "MRE11", "MSH2", "MSH6", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MUT", "MVD", "MYH10", "MYH9", "MYL6", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFM", "NEO1", "NEU1", "NLN", "NME1", "NME2", "NNT", "NPC2", "NRP1", "NSD2", "NSDHL", "NSF", "NT5C2", "NUDT5", "OAT", "OGDH", "ORC5", "OXCT1", "P4HA1", "P4HA2", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARP1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PECR", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PI4KB", "PIGS", "PIK3R4", "PIN1", "PKM", "PLA2G15", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PMPCA", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPCDC", "PPID", "PPIE", "PPIH", "PPIL1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PPT2", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PTGES2", "PTPN1", "PTPN11", "PUF60", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "RAB3B", "RAB5A", "RAB5C", "RABEP1", "RAD21", "RAD23B", "RAD50", "RALA", "RARS", "RB1", "RBM17", "RBM22", "RBM25", "RBM8A", "RBMX", "RBPJ", "RCOR1", "RDH11", "RDX", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RNASEH2B", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RUVBL1", "SAE1", "SARS", "SARS2", "SART1", "SCARB2", "SCD", "SCP2", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC61A1", "SEC61B", "SEC63", "SEPHS1", "SETD1A", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SGPL1", "SH3GL1", "SHMT1", "SHMT2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC19A1", "SLC25A10", "SLC25A17", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLIT2", "SLK", "SLTM", "SMC1A", "SMC3", "SMNDC1", "SMPD4", "SNAP23", "SNAP29", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SOD2", "SORT1", "SPCS2", "SPCS3", "SPTAN1", "SPTLC1", "SPTLC2", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "STAG2", "STAT1", "STAT3", "STIP1", "STMN1", "STT3A", "STUB1", "STX12", "STX7", "STX8", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SYMPK", "TAB1", "TALDO1", "TARS", "TARS2", "TCERG1", "TECR", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TOLLIP", "TOMM40", "TP53", "TPI1", "TPM3", "TPP1", "TPR", "TRA2A", "TRA2B", "TRIM21", "TRIM25", "TRIP12", "TROVE2", "TSG101", "TSTA3", "TTC37", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TXNDC12", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", 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3.2521255837555954 1.3165243686049508 0.3716278052198193 1.0 1.0 0.0048926573587283 0.0036316944643089 1.6413345646756964e-05 +Scf skp2 mediated degradation of p27 p21 20 39 2.979312308025016 0.0028889615924765 12.78883495145631 40.70873786407767 0.5921499036968256 0.5162943652980111 7.12520288261254 1.2647657441579598 1.3047123749289669 0.3686628673319737 1.0 1.0 0.0007143113819537 0.0001565700752818 1.2585437724050869e-08 +Dna replication 42 73 2.966808338023442 0.0030090847279216 24.50242718446602 88.36650485436893 0.2923135263536031 0.6312906600612657 12.317305449092803 5.805851117746023 1.1877285197942282 0.3655243748981305 1.0 1.0 0.0037086091079598 0.0030109656592304 6.64895764369694e-08 +Cyclin a cdk2 associated events at s phase entry 20 40 2.960868035682516 0.003067733521433 13.196601941747574 42.85679611650485 0.6136168472607347 0.5150313285959647 7.221373891468615 2.098630488986879 1.3159566032429193 0.3694066609952225 1.0 1.0 0.002944020969503 0.0016192927445586 2.6922006823916417e-06 +C type lectin receptors clrs 27 44 2.9488357687040807 0.0031897343256048 15.640776699029129 51.34708737864078 0.3190386727488686 0.5456940089786598 8.889127611188893 4.137023959900662 1.350649221433646 0.371203640545422 1.0 1.0 0.0068221584628203 0.0014857052523796 1.2730612716270958e-05 +Transcriptional regulation by runx2 31 51 2.93967791605108 0.0032855358187904 16.021844660194176 51.64320388349515 0.5147340657969439 0.5490234274922848 8.286848189022676 3.0091087328640205 1.321202711135219 0.3758826947187164 1.0 1.0 0.0068221584628203 0.0060973280512552 1.2730612716270958e-05 +Regulation of mrna stability by proteins that bind au rich elements 24 58 2.914147289954216 0.0035666158617242 17.303398058252426 62.189320388349515 0.3637537395774206 0.6066390862029128 8.19973289328142 2.9201480419101515 1.0954480785949263 0.3602041660944462 1.0 0.208387339116985 0.0003140274019637 5.126810603865749e-05 1.382189871878614e-08 +Beta catenin independent wnt signaling 21 49 2.9060900554180344 0.0036597610250681 14.62864077669903 53.63106796116505 0.2467758551278147 0.5921017130101743 7.928102596073744 3.656329241145158 1.1545689159912884 0.3649233327912332 1.0 0.2930103630572701 0.0018691294723692 0.0039769389037481 0.0003130231161726 +Pcp ce pathway 21 47 2.900154255722486 0.0037297905870905 13.383495145631068 48.61407766990291 0.2861400551198787 0.573085795011315 7.677259284018882 2.3137612538026593 1.2152839684208736 0.370148963517148 1.0 0.2060332174005789 0.0002958822012125 0.0002816173407087 2.276141094981061e-06 +Switching of origins to a post replicative state 24 51 2.898195811193004 0.0037531618625357 16.810679611650485 58.20873786407767 0.6859740885709421 0.5709255515574044 8.560355820358037 3.2791073494099976 1.198149892515979 0.3860301174542495 1.0 1.0 0.0038347152886552 0.0005074703728798 2.666242936949891e-07 +Defective cftr causes cystic fibrosis 20 40 2.887108918134126 0.0038879961349869 11.91019417475728 41.73300970873787 0.7347522269055131 0.5083451081080875 6.270921717387096 1.5205957155019303 1.1156147917216153 0.3576346657028889 1.0 1.0 0.0007143113819537 1.955503799635051e-05 1.2585437724050869e-08 +Abc transporter disorders 20 40 2.887108918134126 0.0038879961349869 11.927184466019416 42.31310679611651 0.7277639006737601 0.5118740464528959 6.253118743036628 1.9845331695932795 1.1074811893524887 0.3608608076542074 1.0 1.0 0.0011326416285587 4.855969833914876e-05 7.601961261052206e-08 +Downstream signaling events of b cell receptor bcr 19 38 2.881054051020786 0.0039634766489831 13.109223300970871 42.81310679611651 0.5337893000107979 0.5120527765027618 7.35013455914348 2.784583610128895 1.330630298725885 0.3688632335833426 1.0 1.0 0.0019922851358828 0.0008601455034058 3.63144995815947e-06 +Fceri mediated nf kb activation 19 40 2.8748160017131728 0.0040426300890965 13.599514563106796 43.58252427184466 0.43538002101356 0.532490131621357 7.591659945968655 2.4879291964009105 1.318650463428372 0.3690692407606546 1.0 1.0 0.0016985627648569 0.0006624964647278 2.112303365904471e-06 +Fc epsilon receptor fceri signaling 20 44 2.873574095327491 0.0040585586441101 16.155339805825243 52.529126213592235 0.3577248991718689 0.5588293080975716 8.909749521452186 4.003836293074435 1.3201566724870089 0.369825714615891 1.0 1.0 0.0089121206039033 0.0091856872969618 0.0001271831210662 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 22 45 2.8656675867325343 0.0041613094994616 14.026699029126211 48.65533980582524 0.5636343266746052 0.5641920682636952 7.183906351200202 2.917580729254371 1.1799230201059223 0.3753446211108022 1.0 1.0 0.0016985627648569 0.0001069654242725 5.4698988277933727e-08 +Regulation of runx2 expression and activity 19 42 2.860127381149132 0.0042347087508718 13.184466019417476 42.609223300970875 0.5014097272359687 0.5334388394290158 7.623733474716015 1.80350585730159 1.3084091861848088 0.3700608446837968 1.0 1.0 0.0011326416285587 0.0003390595067652 5.199505862297707e-07 +Hedgehog ligand biogenesis 19 39 2.8541335060613293 0.0043154391818907 11.735436893203884 40.279126213592235 0.705289766689403 0.5138056150617029 6.1754608769009325 1.552402214168598 1.168348102852658 0.3656259469969254 1.0 1.0 0.0006651795478926 0.0001388088667413 7.810060057762894e-08 +Negative regulation of notch4 signaling 19 39 2.8498540575193605 0.0043739293843123 12.218446601941748 39.786407766990294 0.5856668642754154 0.5088435203982538 7.300807876201572 1.1247479582770583 1.3003786017754655 0.3684988575140048 1.0 1.0 0.0004923990677019 8.327760182189775e-05 2.602260870544301e-08 +Apc c mediated degradation of cell cycle proteins 24 51 2.840247432676465 0.0045078553674924 16.58009708737864 56.25970873786408 0.4894986081915347 0.5846445085026403 8.225929403640711 3.549651687085986 1.2134956516570392 0.3755323963670207 1.0 1.0 0.0032231886146148 0.0003653506502519 1.273349840018733e-07 +Degradation of beta catenin by the destruction complex 20 47 2.836500516684355 0.0045610904563313 14.8252427184466 48.63834951456311 0.4830095996380346 0.5534777326316677 8.029589918636947 2.025992551710678 1.2813542829769398 0.3757731368449524 1.0 1.0 0.0002785441454369 0.0002574812904619 1.9186102640521447e-06 +Hedgehog on state 19 40 2.823298546387844 0.0047532287178728 12.5752427184466 41.80339805825243 0.5567751925024539 0.5304257926517765 6.636298293339077 1.8972867972618663 1.2545866277969462 0.3643204702561447 1.0 1.0 0.0018907552608246 0.0001316054825003 3.042136513340998e-06 +Tcr signaling 19 41 2.819522609519849 0.0048095142635944 14.79368932038835 47.728155339805824 0.3776708616120087 0.5474588628929388 8.50292119881085 3.2417009042427978 1.3249802424411328 0.3685330173213761 1.0 1.0 0.0038347152886552 0.002470852217699 3.1616095372840495e-05 +Dna replication pre initiation 33 54 2.770891092189698 0.0055903121250207 16.987864077669904 61.73300970873787 0.4288945668380205 0.5957541730468855 9.845276246498855 3.587542857888571 1.230696609236802 0.3684137615844171 1.0 1.0 0.0050861892859451 0.0038597939309186 4.1983378137467705e-06 +Mapk family signaling cascades 36 76 2.764096438517391 0.0057080666244018 23.104368932038835 88.2864077669903 0.366998662581797 0.5880023171217027 11.41393630950696 5.588694353030067 1.1675181672079205 0.3704838978698669 1.0 0.4680777453812632 0.0218744528643562 0.0422434929484168 0.0008165393724328 +Cross presentation of soluble exogenous antigens endosomes 18 36 2.756399117137711 0.0058441637465809 11.097087378640778 36.91019417475728 0.6471378136535638 0.507052502601231 6.457500437861876 1.2421375880066114 1.2717860238430438 0.3672755762882163 1.0 1.0 0.0002463467072552 2.5266486363512325e-05 2.0402258007764e-08 +Degradation of axin 18 36 2.756399117137711 0.0058441637465809 11.135922330097088 36.5 0.6371703324335989 0.5044883973483546 6.515923056292238 1.1005294401076644 1.2875505119575097 0.3689236351245595 1.0 1.0 0.0004547900330889 7.271039054902884e-05 1.6584825840013934e-07 +Metabolism of polyamines 18 37 2.7400997724742604 0.0061420536177427 11.783980582524272 38.49271844660194 0.5956280690899458 0.5058612771265996 6.813709458301494 1.1915745430318114 1.300721756016792 0.3709861514268986 1.0 1.0 0.0004547900330889 7.271039054902884e-05 1.6584825840013934e-07 +Regulation of runx3 expression and activity 18 37 2.734221279137797 0.0062528007921913 11.46359223300971 36.730582524271846 0.6696914114866416 0.4949350431730664 6.642474003130895 1.4202887203012589 1.288769965462232 0.3632605735082652 1.0 1.0 0.0006184927523534 0.0001227172693247 4.605268823045207e-07 +Orc1 removal from chromatin 26 45 2.7340377249903645 0.0062562875987626 14.364077669902912 49.74757281553398 0.6917566411101944 0.5422658696614091 8.355189705990739 2.308567607855075 1.2721915859610031 0.3803308697876651 1.0 1.0 0.0014363946692659 0.0005027068786363 1.18791833766034e-06 +Regulation of ras by gaps 18 37 2.707554078901456 0.0067781026783226 11.558252427184469 38.29611650485437 0.5949031665539309 0.5179046122727133 6.637200606991292 1.5039380235434 1.2829290056167597 0.3733028763215757 1.0 1.0 0.0008770840410322 0.0002211704177902 1.435858050122039e-06 +Degradation of dvl 18 37 2.707554078901456 0.0067781026783226 11.50728155339806 37.79611650485437 0.5954952616194853 0.5106657090472662 6.536116642578212 1.2295647923796569 1.2774118860610646 0.3695881914917919 1.0 1.0 0.0005321726510817 9.506416166079168e-05 2.8018462395262217e-07 +Uch proteinases 19 44 2.665339612458974 0.0076910608896361 12.934466019417476 45.69174757281554 0.4676332859413379 0.5268776688735902 7.345038379241775 2.489712786954197 1.2496925486564852 0.3629400025319104 1.0 1.0 0.002944020969503 0.0003075721840556 1.3357693241842658e-05 +Cdt1 association with the cdc6 orc origin complex 18 37 2.658723389299096 0.007843733199532 11.8373786407767 39.713592233009706 0.7088745358379469 0.5132999135100862 6.7665841522618235 1.8864642297262784 1.2345641700762902 0.3668156388656303 1.0 1.0 0.0007143113819537 0.0001565700752818 7.382105144119943e-07 +Asymmetric localization of pcp proteins 18 37 2.618005251910392 0.0088445443851228 11.28883495145631 37.80825242718446 0.5764639774033125 0.5188050170985335 6.482730726459962 1.1863421199640956 1.2423982841678427 0.3682278814782295 1.0 1.0 0.0007143113819537 0.0001565700752818 7.382105144119943e-07 +Abc family proteins mediated transport 21 46 2.5720440081735947 0.0101100039476302 13.317961165048544 51.41990291262136 0.8313343047168666 0.503384351224866 6.603791770344115 3.017890343683211 1.0258838915302482 0.3681223740303289 1.0 1.0 0.0024362429880278 0.0002142744178315 2.357318713462034e-07 +Cellular response to hypoxia 18 38 2.566295864531735 0.0102791109244586 12.067961165048544 40.00485436893204 0.522970313217548 0.5163863933875538 6.981963081004602 1.736242938617286 1.3015320227429066 0.3618367398400983 1.0 1.0 0.0009991222727999 0.0002750708350024 2.1805041031338616e-06 +Runx1 regulates transcription of genes involved in differentiation of hscs 19 41 2.565526048128965 0.0103019485933215 11.74514563106796 40.9247572815534 0.4838158037368226 0.5501011058260618 6.5789160679611225 1.5190277579548277 1.1933646193238052 0.3604187581137549 1.0 1.0 0.0016985627648569 0.0001069654242725 2.112303365904471e-06 +Stabilization of p53 18 38 2.532497076017179 0.0113253314365127 11.759708737864075 38.849514563106794 0.5626554032387434 0.5211156380328503 6.862945949053685 1.536505541452464 1.2546862993954295 0.3691198814060923 1.0 1.0 0.000574180538616 0.0001081741563921 3.603892415751964e-07 +G1 s dna damage checkpoints 18 38 2.532497076017179 0.0113253314365127 12.276699029126211 40.3252427184466 0.5620621733571898 0.5261130346169095 7.080750657966309 1.8659034848764728 1.2552712987328345 0.3710523646543767 1.0 1.0 0.0011326416285587 0.0003390595067652 3.249747265786882e-06 +Regulation of pten stability and activity 18 40 2.522477061059881 0.0116531550219625 12.611650485436892 41.82281553398058 0.6486618107800725 0.5229501310802542 7.056269001912706 2.1755846965350556 1.2659780846667748 0.3745012259374719 1.0 1.0 0.0012782100795705 0.0004144635669718 4.759722479200683e-06 +Adaptive immune system 69 149 2.49961693644398 0.0124327659896685 46.463592233009706 186.4004854368932 0.1339433536175087 0.6962113214501324 20.006579857169463 16.487632898609263 1.0633527271457623 0.3569087738025599 1.0 0.7819571104966314 0.3321653695705919 0.1360314522115679 0.0005667220027405 +Antigen processing cross presentation 19 47 2.495215018918042 0.012588082512758 13.364077669902912 51.03883495145631 0.6606344305939695 0.5456453275819227 6.483621701094183 2.525298521609755 1.0422529083240153 0.3659829171921698 1.0 1.0 0.0026818836851232 0.0002574812904619 9.817855850191216e-06 +Hedgehog off state 27 48 2.466093851297267 0.0136595539117156 15.740291262135925 51.0752427184466 0.6256619133963464 0.5308625548821857 8.054006294440956 2.7424510136822824 1.3127807939810612 0.3772173866259285 1.0 1.0 0.0059116882291254 0.001140094128738 7.432005868447484e-06 +Regulation of hmox1 expression and activity 19 43 2.463675084225537 0.0137520711863388 12.524271844660197 45.58009708737864 0.7171016159839839 0.514573723238038 7.335701580194855 2.006274620945924 1.1938232298543638 0.3651188593292154 1.0 1.0 0.000936703527992 0.0002469387579182 2.662236363252087e-07 +Signaling by hedgehog 30 53 2.450184425299153 0.0142783061033675 16.28640776699029 57.470873786407765 0.6189752673658386 0.5630638540633491 8.199307909979849 3.6419383260123857 1.1996921179618314 0.3729858641615031 1.0 1.0 0.0134992936568226 0.005121340106681 4.391561840539977e-05 +Hsf1 dependent transactivation 4 13 2.427209431319508 0.0152154696233755 5.618932038834951 14.279126213592232 -0.3527812083435748 0.559467497755984 3.734895902585274 1.5176154051836428 0.8414177838280088 0.310660480416511 1.0 0.084720842262428 0.2036723289623047 0.0038435359651512 0.0113677172651175 +Signaling by notch4 19 42 2.4246478850099176 0.0153232409286265 12.74271844660194 42.689320388349515 0.5846962923720355 0.527528574888472 7.095179574371064 1.5202779907622044 1.22282479858509 0.3678962187540617 1.0 1.0 0.0019922851358828 0.0008601455034058 3.63144995815947e-06 +Signaling by interleukins 44 99 2.3850141778145653 0.0170784631506843 26.51456310679612 106.8131067961165 0.2659215907627361 0.6379218100870152 12.507367985924851 6.646155400677433 1.0797762015608217 0.3618033258723105 1.0 0.5227832512980728 0.0026150594624027 0.0197880087993402 0.0004992826997862 +Cell cycle checkpoints 49 115 2.372207018501356 0.0176821803683724 35.737864077669904 139.23300970873785 0.0395895335097635 0.683101356311267 14.89377348564558 13.286392691301824 0.9326100500655764 0.3317969957493373 1.0 0.5355853970281734 0.0445957292831474 0.0040838981245699 0.0001448983078432 +The role of gtse1 in g2 m progression after g2 checkpoint 21 47 2.325296978860916 0.0200560857350389 14.79611650485437 48.84466019417476 0.6226477470486884 0.5168095546238419 7.820323564061835 1.8499922936255029 1.3076695437390702 0.3722860732713196 1.0 1.0 0.0016077607071251 9.61580846895438e-05 2.882910377985604e-07 +Transcriptional regulation by runx3 18 42 2.309901239070354 0.020893622462248 12.155339805825244 41.550970873786405 0.5220991170779611 0.5409180415581131 7.051829317928235 1.9320556056256075 1.205315041796802 0.3587760476843317 1.0 1.0 0.0039990552173452 0.0026411234565286 0.0001496196702518 +Attenuation phase 3 11 2.2803082003609108 0.0225894157907209 5.5 11.118932038834952 -0.4337073514143714 0.4842081320796569 3.2144244075486763 0.9179603949209442 0.9436906363931746 0.3126089504565827 1.0 0.0628328620388111 0.1537553372636865 0.0115542255002619 0.0170771654017561 +Hsf1 activation 3 13 2.2565409068470026 0.0240367764401367 6.262135922330097 13.847087378640778 -0.4333250288126234 0.4743355436386303 3.5057820895194016 1.0536189424360778 0.9971080545369552 0.3169703406464311 1.0 0.0710995046607905 0.1728260768139309 0.0164525276609661 0.0264892743716575 +Retrograde transport at the trans golgi network 4 10 2.227280071856615 0.0259285615389703 4.779126213592233 17.143203883495147 0.3613851487031342 0.4884664603565215 2.6268315318443034 3.9886218545053063 1.007707670827069 0.3163228122840523 1.0 0.1347425270434581 0.0527005247491891 0.0215809279802187 0.0246917840308845 +Signaling by vegf 2 18 2.2209835631171684 0.0263520746984282 6.883495145631068 27.983009708737864 0.1011969204766448 0.6075816398278557 4.577914416556544 4.622885522409548 0.8310376757580115 0.3053476903879352 1.0 0.0268217106000978 0.1400494269642578 0.2942552420296088 0.7740470891656014 +G2 m checkpoints 35 74 2.18081282989363 0.0291972632263612 20.961165048543688 83.21601941747574 0.2497590522742128 0.6198120617040068 11.249096904504546 6.6438113169442845 1.0983784482763044 0.3587806160447286 1.0 0.3279720258259928 0.0033728455987964 0.0006775876581263 4.3392561189554815e-05 +Transcriptional regulation by runx1 25 63 2.1547468706025903 0.031181647841131 17.660194174757283 67.73058252427184 0.0956433719082077 0.6467498474297692 8.588831535590984 5.0191610185934845 0.9164516867594036 0.3343217460909707 1.0 1.0 0.0008894026195973 0.0015293445375086 1.6662591113462524e-05 +Extra nuclear estrogen signaling 0 7 2.123812336198253 0.0336858390415977 4.060679611650485 12.66019417475728 -0.2558236013439511 0.5713535791547126 2.8597826525247334 2.1724372159953886 0.8182359659242324 0.2894913790372623 1.0 0.1296041755358818 0.3002970578344975 0.6454885854012022 0.6470150159337004 +Interleukin 1 family signaling 21 47 2.103003043612165 0.0354655034362183 14.592233009708735 49.06310679611651 0.4308069558259447 0.5378127516815151 8.12336542865419 3.453701835311694 1.3196847762251946 0.3781683305809454 1.0 1.0 0.00569749052339 0.0046096879647335 6.463825837729106e-06 +Programmed cell death 37 89 2.066680747353269 0.0387642464848947 24.810679611650485 99.90533980582524 0.0752454735319569 0.6272894434318409 12.51748611988162 5.728761589606555 1.018486798771118 0.3435170341557741 1.0 1.0 0.0022762903764289 0.005750025234511 0.0002273137234222 +Metabolism of vitamins and cofactors 4 36 2.062972159849996 0.0391152733404327 9.468446601941748 45.929611650485434 -1.0750842825536984 0.3149569447417751 3.9574771941597184 5.663492082419755 1.591669835914462 0.3340430450319153 1.0 0.0069532409493471 0.0033728455987964 0.0723459446055529 0.1683474307531424 +Sting mediated induction of host immune responses 0 6 2.0596005898034218 0.0394367398055601 2.262135922330097 6.036407766990291 -0.0301785213505694 0.5056398973526773 1.7788463865556277 0.5583737732194141 0.9710900078272215 0.3001381754391826 1.0 0.0290494193324047 0.0730355121895775 0.1976706468543551 0.3776164066261946 +Apoptosis 34 79 2.045987853305591 0.0407575657626648 22.723300970873787 88.14805825242719 0.0393529046833614 0.6051308661069602 11.01526481781096 5.029516867347871 1.0330743537895812 0.3410297528233371 1.0 1.0 0.0069422334625708 0.0228825931114847 0.0003937923805426 +Transcriptional activation of mitochondrial biogenesis 1 10 2.042667248123053 0.0410853891040368 3.75 12.432038834951456 -0.1281260555520316 0.4644247929939951 2.038018502731447 1.8754268688059847 1.067682850482272 0.2998511345858375 1.0 0.1398515498272073 0.3212941459452473 0.305305310334077 0.4224939325951405 +Separation of sister chromatids 40 87 2.02715571291501 0.0426464906983174 27.25728155339806 104.59466019417476 0.1913519656937572 0.6759734454858931 10.904342253831215 7.99139528936842 0.9289444053822858 0.343574417926859 1.0 1.0 0.0462237377677715 0.005750025234511 2.616259416202713e-05 +Interconversion of nucleotide di and triphosphates 1 15 2.025118029887145 0.0428552459548612 5.497572815533981 17.694174757281555 -0.1681971791529782 0.4897251001051131 3.6513721229998217 1.854845412275771 1.091743890900105 0.3245015655397826 0.002550019615475 0.0738393547118652 0.1790882331510777 0.1091182558828044 0.1168593303284982 +Intracellular signaling by second messengers 32 72 2.0013231073896285 0.0453575811123894 23.20145631067961 86.0631067961165 0.1421070399989671 0.655790329270176 10.291654542344736 8.129468035609259 0.948765500839012 0.3384114915870303 1.0 1.0 0.0993056471106511 0.1364061688271062 0.0229999062573182 +Signaling by insulin receptor 3 13 1.96165192704808 0.0498030222692111 3.91504854368932 15.699029126213592 0.5754214954087689 0.534682491573688 2.331728544953775 1.4948776711085254 0.7798073838753424 0.3154925742571588 1.0 0.1244363327921815 0.289559371799862 0.6294576819736278 0.1536224858641393 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..adc432b4e0cd83b1f2390880d0004f0433ca6092 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 1321, + "title": "Average number of proteins per term", + "value": 17.064345193035578 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..37fc68622e34fd9a49d644850a80cee7c7dccc7b --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..191416e92cf9876eeab79ca86f872f9398c5360e --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,500 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Antigen processing ubiquitination proteasome degradation 0.5460045878238674 3.675543814086308 0.000237343301777 0.2691651109504041 0.1069992725310486 77 Q92530,Q7Z6E9,Q16763,P48556,Q15386,P19474,Q9UJX4,Q13200,Q9ULT8,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P61081,Q8TBC4,A0AVT1,Q99436,P63208,P51665,Q9UIQ6,P20618,Q93034,Q13867,O43242,Q9UJX2,P60900,Q15008,P55786,Q06323,Q96J02,Q14139 36 +Class i mhc mediated antigen processing presentation 0.4859766053803556 3.3063804076538843 0.0009450968446573 0.7132266990998092 0.1069992725310486 93 Q92530,Q7Z6E9,Q16763,P48556,Q15386,P19474,Q9UJX4,Q13200,Q9ULT8,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P61081,Q8TBC4,A0AVT1,Q99436,P63208,P51665,Q9UIQ6,P20618,Q93034,Q13867,O43242,Q9UJX2,P60900,Q15008,P55786,Q15436,Q06323,Q96J02,Q14139 37 +Auf1 hnrnp d0 binds and destabilizes mrna 0.6126992220544354 3.2978612694983847 0.0009742425636185 0.7240682555720971 0.1069992725310486 41 P04792,P48556,Q13200,Q04637,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Neddylation 0.529186404152087 3.1697301032686864 0.0015258059282923 0.86696312007428 0.1069992725310486 62 Q9UNS2,P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P61081,P28070,P61201,Q8TBC4,Q99436,P61964,P63208,Q9UBW8,P51665,P20618,Q93034,Q99627,O43242,P60900,Q15008,Q5TAQ9,Q06323,Q92530 28 +Synthesis of dna 0.5057944099310957 3.1688400074756253 0.0015304861905878 0.867784351071267 0.1069992725310486 68 Q16763,P51530,P48556,Q9UJX4,Q13200,P25789,P30260,P25787,P49721,Q99460,Q9BRT9,P28072,P28074,Q9UL46,P28070,O00231,Q99436,P41440,P63208,P49642,P39748,Q07864,P51665,P15927,P09884,P20618,O43242,P60900,Q9UJX2,Q15008,Q06323,Q92530 32 +Mapk6 mapk4 signaling 0.583732357883407 3.163223600927884 0.0015603243815527 0.8729021788919521 0.1069992725310486 46 P04792,P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P06493,P17612,P35998,P51665,P25685,P60953,P20618,O43242,Q13177,P60900,Q15008,Q06323,Q92530 27 +Mitotic g1 phase and g1 s transition 0.5112696268565432 3.1234097242383236 0.0017876869662294 0.9059235795654204 0.1069992725310486 65 P30153,P48556,P00374,Q13200,P63151,P25789,P31350,P27694,P33991,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P14635,Q99436,P06493,P63208,P49642,P35998,Q07864,P51665,P15927,P33993,P62191,P09884,P20618,P11802,O43242,Q13547,O14818,P60900,P06400,Q15008,P25205,Q06323,Q92530 41 +Dectin 1 mediated noncanonical nf kb signaling 0.5965367037052889 3.106527024740306 0.0018929900487676 0.9181616802766828 0.1069992725310486 40 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P61081,P28070,Q8TBC4,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +Tnfr2 non canonical nf kb pathway 0.5965367037052889 3.106527024740306 0.0018929900487676 0.9181616802766828 0.1069992725310486 40 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P61081,P28070,Q8TBC4,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +Clec7a dectin 1 signaling 0.5819038596173964 3.0715219219303846 0.002129705249952 0.9401755410191032 0.1069992725310486 42 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P61081,P28070,Q8TBC4,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +S phase 0.4847101928782604 3.026841908544693 0.0024712316687305 0.9619379423926 0.1069992725310486 77 Q92530,Q16763,P51530,P48556,Q9UJX4,Q13200,P25789,P27694,P30260,P33991,P25787,P49721,Q99460,Q9BRT9,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P41440,P63208,P49642,P35998,P39748,Q07864,P51665,P33993,P62191,P09884,P20618,P11802,Q8N3U4,O43242,O14818,Q9UJX2,P06400,P60900,Q15008,P25205,Q06323,P15927 43 +Degradation of gli1 by the proteasome 0.5820919308016109 2.9932028836405467 0.0027606616321873 0.9740576143728096 0.1069992725310486 40 Q92530,P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q96J02 20 +Signaling by the b cell receptor bcr 0.588875028004418 2.986082329014394 0.0028257655584389 0.976201204752451 0.1069992725310486 39 P48556,Q13200,P25789,P62993,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Scf skp2 mediated degradation of p27 p21 0.5880028715071904 2.979312308025016 0.0028889615924765 0.9781125420440222 0.1069992725310486 39 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,P11802,Q06323,Q92530 20 +Dna replication 0.4828550021209398 2.966808338023442 0.0030090847279216 0.9813329157634588 0.1069992725310486 73 Q16763,P51530,P48556,Q9UJX4,Q13200,P25789,P27694,P30260,P33991,P25787,P49721,Q99460,Q9BRT9,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q14974,Q99436,P41440,P63208,P49642,P35998,P39748,Q07864,P51665,P15927,P33993,P62191,P09884,P20618,O43242,O14818,P60900,Q9UJX2,Q15008,P25205,Q06323,Q92530,O60684 42 +Cyclin a cdk2 associated events at s phase entry 0.5780027458698334 2.960868035682516 0.003067733521433 0.9827286234418644 0.1069992725310486 40 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,P11802,Q06323,Q92530 20 +C type lectin receptors clrs 0.5625476027859863 2.9488357687040807 0.0031897343256048 0.9853068453447972 0.1069992725310486 44 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P61081,P28070,Q8TBC4,Q9UNM6,O00231,Q99436,P17612,P63208,P35998,P51665,P62191,P20618,O43242,Q13177,P60900,Q15008,Q06323,Q92530 27 +Transcriptional regulation by runx2 0.5436115806075675 2.93967791605108 0.0032855358187904 0.9870587889129178 0.1069992725310486 51 Q96PK6,P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P14635,Q99436,P06493,P63208,P35998,P51665,P62191,P20618,O43242,O14818,P17931,P06400,Q07812,P60900,Q15008,P11802,Q06323,Q92530 31 +Regulation of mrna stability by proteins that bind au rich elements 0.5181091992692181 2.914147289954216 0.0035666158617242 0.9910841228253104 0.1069992725310486 58 P04792,Q92945,Q92973,P48556,Q13200,Q9Y2L1,Q04637,P25789,Q01105,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 24 +Beta catenin independent wnt signaling 0.5453348849900416 2.9060900554180344 0.0036597610250681 0.9921198835424924 0.1069992725310486 49 P48556,Q13200,P61586,P25789,P09497,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P53680,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +Pcp ce pathway 0.5497671231289515 2.900154255722486 0.0037297905870905 0.9928186271939462 0.1069992725310486 47 P48556,Q13200,P61586,P25789,P09497,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P53680,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +Switching of origins to a post replicative state 0.5389059890114333 2.8981958111930037 0.0037531618625357 0.993037760690796 0.1069992725310486 51 Q16763,P48556,Q9UJX4,Q13200,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,O00231,Q99436,P63208,P51665,P20618,O43242,P60900,Q9UJX2,Q15008,Q06323,Q92530 24 +Defective cftr causes cystic fibrosis 0.5687279834127064 2.887108918134126 0.0038879961349869 0.9941776615777322 0.1069992725310486 40 P48556,Q13200,Q9BUN8,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Abc transporter disorders 0.5687279834127065 2.887108918134126 0.0038879961349869 0.9941776615777322 0.1069992725310486 40 P48556,Q13200,Q9BUN8,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Downstream signaling events of b cell receptor bcr 0.5826509932481174 2.881054051020786 0.0039634766489831 0.9947322715481632 0.1069992725310486 38 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Fceri mediated nf kb activation 0.5671893495005882 2.8748160017131728 0.0040426300890965 0.9952572492562926 0.1069992725310486 40 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Fc epsilon receptor fceri signaling 0.5534842966339014 2.873574095327491 0.0040585586441101 0.9953563992259498 0.1069992725310486 44 P48556,Q13200,P25789,P62993,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.5503689652453168 2.8656675867325343 0.0041613094994616 0.9959480588823024 0.1069992725310486 45 Q16763,P48556,Q9UJX4,Q13200,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q9UJX2,Q15008,Q06323,Q92530 22 +Regulation of runx2 expression and activity 0.5558893231859745 2.8601273811491317 0.0042347087508718 0.9963239938158168 0.1069992725310486 42 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Hedgehog ligand biogenesis 0.5719910059480247 2.8541335060613293 0.0043154391818907 0.9966973535054946 0.1069992725310486 39 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Negative regulation of notch4 signaling 0.5714474206679243 2.8498540575193605 0.0043739293843123 0.9969439556049496 0.1069992725310486 39 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Apc c mediated degradation of cell cycle proteins 0.5323655992618357 2.8402474326764655 0.0045078553674924 0.9974415131646452 0.107592865943102 51 Q16763,P48556,Q9UJX4,Q13200,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,O00231,Q99436,P63208,P51665,P20618,O43242,P60900,Q9UJX2,Q15008,Q06323,Q92530 24 +Degradation of beta catenin by the destruction complex 0.542323575570229 2.836500516684355 0.0045610904563313 0.9976160181911962 0.107592865943102 47 P48556,Q13200,P25789,Q13363,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 20 +Hedgehog on state 0.5607631595820051 2.823298546387844 0.0047532287178728 0.9981526172858636 0.1076842091899704 40 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q96J02,Q06323,Q92530 19 +Tcr signaling 0.5527755213835246 2.819522609519849 0.0048095142635944 0.9982856063451804 0.1076842091899704 41 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Dna replication pre initiation 0.5159556832360246 2.770891092189698 0.0055903121250207 0.9993921128155148 0.1187713893728215 54 P48556,Q13200,P25789,P27694,P33991,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q14974,Q99436,P49642,P35998,Q07864,P51665,P15927,P33993,P62191,P09884,P20618,O43242,O14818,P60900,Q15008,P25205,Q06323,Q92530,O60684 33 +Mapk family signaling cascades 0.4617979087468344 2.764096438517391 0.0057080666244018 0.999480143987426 0.1187713893728215 76 Q92530,P04792,P48556,Q13200,Q9UQ13,P25789,Q06124,P62993,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P35609,Q99436,P06493,P17612,P35998,P51665,P25685,P60953,Q9Y490,P20618,Q96S59,O43242,Q13177,P49354,P18206,P60900,Q15008,Q06323,P30153 36 +Cross presentation of soluble exogenous antigens endosomes 0.5798863695275867 2.756399117137711 0.0058441637465809 0.9995661394852936 0.1187713893728215 36 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Degradation of axin 0.5798863695275867 2.756399117137711 0.0058441637465809 0.9995661394852936 0.1187713893728215 36 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Metabolism of polyamines 0.5712281207396004 2.7400997724742604 0.0061420536177427 0.9997079754183246 0.1197761727241366 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Regulation of runx3 expression and activity 0.5704649185672785 2.734221279137797 0.0062528007921913 0.9997479497062935 0.1197761727241366 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Orc1 removal from chromatin 0.5348273945257686 2.7340377249903645 0.0062562875987626 0.9997491152716308 0.1197761727241366 45 P48556,Q13200,P25789,P33991,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P63208,P35998,P51665,P33993,P62191,P20618,O43242,O14818,P60900,Q15008,Q06323,Q92530 26 +Regulation of ras by gaps 0.5670087511271786 2.707554078901456 0.0067781026783226 0.9998746444675124 0.1226558032611543 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Degradation of dvl 0.5670087511271786 2.707554078901456 0.0067781026783226 0.9998746444675124 0.1226558032611543 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Uch proteinases 0.5287759368411822 2.665339612458974 0.0076910608896361 0.9999627985603484 0.1336827820422277 44 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,Q8NB78,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Cdt1 association with the cdc6 orc origin complex 0.5607055418624439 2.658723389299096 0.007843733199532 0.9999696411356296 0.1345658643711922 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Asymmetric localization of pcp proteins 0.5554744458222283 2.618005251910392 0.0088445443851228 0.9999919963916396 0.1410598424235998 37 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Abc family proteins mediated transport 0.5139983586003862 2.5720440081735947 0.0101100039476302 0.9999985197282368 0.1512097121308643 46 P48556,Q13200,Q9BUN8,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P51665,P05198,P20618,O43242,P60900,Q15008,Q06323,Q92530 21 +Cellular response to hypoxia 0.5425216638173526 2.566295864531735 0.0102791109244586 0.9999988187956466 0.1512097121308643 38 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.5221755962030189 2.565526048128965 0.0103019485933215 0.9999988542581656 0.1512097121308643 41 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,P20618,O43242,P60900,Q15008,Q96J02,Q06323,Q92530 19 +Stabilization of p53 0.5382912756228022 2.532497076017179 0.0113253314365127 0.9999997078871824 0.1558121211564691 38 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +G1 s dna damage checkpoints 0.5382912756228022 2.532497076017179 0.0113253314365127 0.9999997078871824 0.1558121211564691 38 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Regulation of pten stability and activity 0.5239291705388752 2.522477061059881 0.0116531550219625 0.9999998115087048 0.1558121211564691 40 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Adaptive immune system 0.391731335989218 2.4996169364439793 0.0124327659896685 0.9999999335378998 0.1558121211564691 149 Q92530,Q7Z6E9,Q16763,P30153,Q14203,P48556,Q15386,Q9Y6G9,P19474,Q9UJX4,Q13200,P68036,Q9ULT8,P25789,P33176,Q06124,O94874,P09429,P30260,P62993,P25787,P49721,Q99460,P28072,P28074,Q9UJW0,Q9UL46,P28070,P61081,Q8TBC4,Q9UNM6,P53680,A0AVT1,O00231,O43237,P52732,Q99436,O95486,P17612,P63208,P35998,Q10567,P51665,O75935,Q9BUF5,P68371,P63104,P60953,Q9BXS5,Q9UIQ6,P62191,P50570,P20618,Q5T4S7,Q93034,O43747,Q13409,Q7Z6Z7,Q13867,O43242,Q13177,Q9UJX2,P60900,Q15008,P55786,Q15436,Q06323,Q96J02,Q14139 69 +Antigen processing cross presentation 0.5032263126897192 2.495215018918042 0.012588082512758 0.9999999460067298 0.1558121211564691 47 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,Q9UIQ6,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Hedgehog off state 0.4978667077010149 2.466093851297267 0.0136595539117156 0.9999999871335532 0.1592501604143031 48 Q92530,P48556,Q13200,P25789,P10644,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P17612,P63208,P35998,P51665,Q9BUF5,P68371,P20618,O43242,P60900,Q15008,Q06323,Q96J02 27 +Regulation of hmox1 expression and activity 0.5070369836919443 2.463675084225537 0.0137520711863388 0.999999988633059 0.1592501604143031 43 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Signaling by hedgehog 0.4843023386205164 2.450184425299153 0.0142783061033675 0.999999994383708 0.1592501604143031 53 Q92530,P48556,Q13200,P25789,P10644,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P17612,P63208,P35998,P51665,Q9BUF5,P68371,P62191,Q6P1J9,P20618,O43242,P60900,Q15008,Q06323,Q96J02 30 +Hsf1 dependent transactivation 0.7285203452711866 2.427209431319508 0.0152154696233755 0.9999999984013672 0.1592501604143031 13 Q96B36,P25685,P04792,Q02790 4 +Signaling by notch4 0.5040826554561891 2.4246478850099176 0.0153232409286265 0.999999998616557 0.1592501604143031 42 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Signaling by interleukins 0.4011276389465289 2.3850141778145653 0.0170784631506843 0.9999999998689604 0.1592501604143031 99 Q92530,P48556,P04179,P04083,Q13200,P08670,P11233,P25789,Q06124,P51452,P09429,P14174,Q99439,P62993,P25787,P49721,O14979,Q99460,P28072,P28074,Q9UL46,P28070,Q00169,Q9UNM6,O00231,Q99436,P17612,P63208,P26038,P35998,P51665,P63104,P60953,P20618,Q13126,O43242,Q13177,P40763,P60900,Q15008,Q15418,P22626,Q06323,P30153 44 +Cell cycle checkpoints 0.3710591537165766 2.372207018501356 0.0176821803683724 0.9999999999418002 0.1592501604143031 115 Q92530,Q16763,Q9UQ84,P51530,P48556,Q9NXR7,Q9Y6G9,Q9UJX4,Q13200,Q92547,O43683,O43264,P25789,P27694,P30260,Q04917,P33991,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,O43237,P14635,Q99436,P06493,P35998,P51665,Q9Y266,P33993,P63104,P62191,Q9P258,Q7Z460,P20618,Q15008,Q13409,O43242,Q15691,Q8NFH4,Q9UJX2,P60900,P15927,Q06323,P30153 49 +The role of gtse1 in g2 m progression after g2 checkpoint 0.4842461617633138 2.325296978860916 0.0200560857350389 0.9999999999976188 0.1687521608661555 47 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,O00231,Q99436,P51665,Q9BUF5,P20618,O43242,Q15691,P60900,Q15008,Q06323,Q92530 21 +Transcriptional regulation by runx3 0.4908073673153081 2.309901239070354 0.020893622462248 0.9999999999992304 0.1735878947964127 42 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323,Q92530 18 +Attenuation phase 0.7205294464128315 2.2803082003609108 0.0225894157907209 0.999999999999922 0.1842013472811256 11 P25685,P04792,Q02790 3 +Hsf1 activation 0.6947640617147505 2.2565409068470026 0.0240367764401367 0.999999999999989 0.1936133029111018 13 P25685,P04792,Q02790 3 +Retrograde transport at the trans golgi network 0.7318939898382348 2.227280071856615 0.0259285615389703 0.9999999999999992 0.2025191635374131 10 P40616,Q5VZE5,P20645,P83436 4 +Signaling by vegf 0.6240209448248912 2.2209835631171684 0.0263520746984282 0.9999999999999996 0.2035736296878581 18 P61586,P04792 2 +G2 m checkpoints 0.4117364853712477 2.18081282989363 0.0291972632263612 1.0 0.2203976269829901 74 Q9UQ84,P51530,P48556,Q9NXR7,Q13200,Q92547,P25789,P27694,Q04917,P33991,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P14635,Q99436,P06493,P35998,P51665,P15927,P33993,P63104,P62191,P20618,O43242,O14818,P60900,Q15008,Q06323,Q92530 35 +Transcriptional regulation by runx1 0.4256132781414956 2.1547468706025903 0.031181647841131 1.0 0.2290129887961947 63 Q92530,P48556,Q99873,Q12824,Q13200,P25789,Q06124,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,O15047,Q99436,P61964,P51665,P20618,O43242,P17931,P60900,Q15008,Q06323,Q96J02 25 +Interleukin 1 family signaling 0.4598634327953416 2.103003043612165 0.0354655034362183 1.0 0.2488072265807574 47 P48556,Q13200,P25789,Q06124,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P40763,P60900,Q15008,Q06323,Q92530 21 +Programmed cell death 0.3901966333118645 2.066680747353269 0.0387642464848947 1.0 0.2582289918821276 89 O43633,P48556,Q13200,Q15149,P08670,P25789,P09429,Q04917,Q8WUM4,P49721,P25787,Q9UDY2,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q14974,Q99436,P41440,P35998,P51665,P63104,P20618,O00273,O43242,Q9NR28,Q13177,P49354,P40763,Q07812,P60900,Q15008,Q06323,Q92530 37 +Metabolism of vitamins and cofactors 0.4914088424133336 2.0629721598499957 0.0391152733404327 1.0 0.2582289918821276 36 P43490,P02656,P34896,O75874 4 +Apoptosis 0.397304445165636 2.045987853305591 0.0407575657626648 1.0 0.2582289918821276 79 P48556,Q13200,Q15149,P08670,P25789,P09429,Q04917,P25787,P49721,Q9UDY2,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q14974,Q99436,P35998,P51665,P63104,P20618,O00273,O43242,Q9NR28,Q13177,P49354,P40763,P60900,Q07812,Q15008,Q06323,Q92530 34 +Transcriptional activation of mitochondrial biogenesis 0.6932199333666103 2.042667248123053 0.0410853891040368 1.0 0.2584466619353934 10 P48735 1 +Separation of sister chromatids 0.3891311089789017 2.02715571291501 0.0426464906983174 1.0 0.2620279730812903 87 Q92530,Q16763,P48556,Q9Y6G9,Q9UJX4,Q13200,O43264,O43683,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,O43237,Q99436,P35998,P51665,Q9Y266,Q9BUF5,P68371,P62191,Q9P258,Q7Z460,P20618,Q13409,Q8N3U4,O43242,Q15691,Q8NFH4,Q9UJX2,P60900,Q15008,Q06323,P30153 40 +Interconversion of nucleotide di and triphosphates 0.6290060883844516 2.025118029887145 0.0428552459548612 1.0 0.2620915736406097 15 Q9H773 1 +Intracellular signaling by second messengers 0.3971095357604286 2.0013231073896285 0.0453575811123894 1.0 0.2748502965571853 72 Q92530,P48556,Q13200,P25789,Q06124,P62993,P10644,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P17612,P35998,P51665,P62191,O95983,P20618,Q6IAA8,Q96B36,O43242,Q13547,Q8WXI9,P60900,Q15008,Q06323,P30153 32 +Signaling by insulin receptor 0.6379180192365965 1.9616519270480797 0.0498030222692111 1.0 0.2950214906620088 13 P62993,Q15904,Q06124 3 +Signaling by receptor tyrosine kinases 0.3789145130416785 1.9509380325999996 0.0510644176966674 1.0 0.2993435749762398 91 P04792,Q9UQB8,Q99570,Q15904,P16949,O14786,P61586,P11233,Q06124,P51452,P42566,P62993,Q8WX92,P61201,P30876,P53680,P60953,P50570,Q93034,P21281,Q96S59,Q13685,P11047,Q13177,P40763,Q07812,Q00535,Q15418,Q96J02 29 +Signaling by notch 0.428331533612783 1.9323296203480165 0.0533188346969997 1.0 0.3089218448891957 54 Q92530,P48556,P67809,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q96J02 22 +Signaling by wnt 0.3885020121793474 1.9147335412232604 0.0555264937623705 1.0 0.3175346245025603 75 P48556,Q13200,P61586,P25789,Q13363,P09497,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P53680,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 23 +Interleukin 1 signaling 0.4412806852097786 1.9036904625191509 0.0569505092991584 1.0 0.3228825012196923 45 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P60900,Q15008,Q06323,Q92530 19 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.5205396851003984 1.8801750078564436 0.0600842305269415 1.0 0.3348998671986911 24 P14174,Q99439,O14979,P04179,Q13177,Q9UL46,Q00169,P60953,P11233,Q13126 10 +Disorders of transmembrane transporters 0.3855481085025893 1.8604551011886792 0.0628211651336119 1.0 0.3443433989273914 70 P48556,Q13200,Q9BUN8,P25789,P25787,P49721,Q99460,O00400,P28072,P28074,Q9UBV2,Q9UL46,P28070,Q99436,P35613,P51665,P20618,O43242,Q8NFH4,P60900,Q15008,Q06323,Q92530 23 +Pten regulation 0.4086934472307805 1.853280267458166 0.0638421979574799 1.0 0.3484939814125247 59 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P51665,O95983,P20618,O43242,Q8WXI9,P60900,Q15008,Q06323,Q92530 20 +Mitotic g2 g2 m phases 0.3829689419176442 1.8444043927108753 0.0651242276227215 1.0 0.3497118076813623 74 Q92530,Q14203,P48556,Q13200,P63151,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P14635,Q99436,P06493,P17612,P63208,P35998,P51665,O75935,Q9BUF5,P68371,P62191,P20618,Q13409,O95684,O43242,Q15691,P60900,Q15008,Q06323,P30153 35 +Signaling by scf kit 0.85441516458168 1.8005343805842482 0.0717762999348012 1.0 0.3694023721574697 4 P40763,Q06124 2 +Peptide hormone metabolism 0.6889846116625604 1.7851508544027856 0.0742368510706219 1.0 0.3728778717273444 8 Q8TAG9,O00471 2 +Cytokine signaling in immune system 0.347060750213591 1.771711471010373 0.0764424645212675 1.0 0.3810584740852621 157 P48556,P04179,P04083,P19474,Q04637,P25789,Q06124,P14174,Q99439,P62993,P25787,P49721,Q9Y4X5,O14979,Q13526,P28072,P28074,Q00169,P28070,Q13325,Q8TBC4,Q99436,P51665,P20618,Q13126,O43242,Q8NFH4,P40763 28 +Dna damage reversal 0.957890433360589 1.7606598695195967 0.0782959888529253 1.0 0.3888308318598284 2 Q9C0B1 1 +Signaling by ntrks 0.4731548122013886 1.7245122422318224 0.0846154108424619 1.0 0.4139887323070082 30 P51452,P62993,Q8WX92,P40763,Q07812,Q00535,P50570,Q15418,P61586,P11233,Q06124 11 +Tcf dependent signaling in response to wnt 0.3992556745278657 1.70500473933111 0.0881935405223299 1.0 0.4194831936265693 57 Q92530,P48556,Q13200,P25789,Q13363,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,Q99436,P35998,P51665,P63104,P62191,Q6P1J9,P20618,O43242,Q13547,P60900,Q15008,Q06323,P30153 27 +Diseases of signal transduction by growth factor receptors and second messengers 0.3304645149723259 1.7045476335869256 0.088278825002412 1.0 0.4194831936265693 122 Q14789,Q92530,Q92734,Q96PU8,Q14203,P48556,Q13200,Q9UQ13,P25789,P33176,Q06124,Q13363,P35579,Q86WB0,P62993,P25787,P49721,Q8IWJ2,Q99460,P28072,P28074,Q9UBV2,Q9UL46,P28070,P30876,O00231,Q99436,P63208,P51665,Q9Y490,P20618,Q96B36,Q15008,Q16630,Q9NRY5,O95684,O43242,P18206,P40763,P60900,O43252,Q06323,P30153 43 +Nucleotide salvage 0.7225773530532675 1.7017643259513096 0.0887995564283463 1.0 0.4204452116195181 6 Q9BZX2,P55263 2 +Interleukin 12 family signaling 0.4703237097382974 1.679221110253748 0.0931089592300213 1.0 0.4330877997987966 29 P14174,Q99439,O14979,P04179,Q13177,P40763,Q9UL46,Q00169,P60953,P11233,Q13126 11 +Signaling by erbb2 0.6899913716452714 1.6571149099197544 0.0974962452580379 1.0 0.444112206847821 7 P62993,P61586 2 +Degradation of the extracellular matrix 0.6842305320426232 1.6315025945801849 0.1027843128303107 1.0 0.4634064069926297 7 P20810,P11047,P07384,P35613 4 +Hiv infection 0.3205535633510226 1.6035848207759364 0.1088055988147798 1.0 0.4839467879943573 115 O43633,P48556,Q9H3P2,Q13200,O00267,P25789,P25787,P49721,Q99460,Q8WX92,P28072,P28074,Q9UL46,P28070,P30876,P53680,O00231,Q99436,P43487,Q99816,P63208,P51665,Q08945,Q9BXS5,P20618,Q93034,O43747,P17096,Q9UN37,O43242,Q8NFH4,P60900,Q15008,Q92804,Q06323,Q92530 36 +Insulin processing 0.8017711373831136 1.5935292802193457 0.1110415051392523 1.0 0.4873283331858883 4 Q8TAG9 1 +Signaling by cytosolic fgfr1 fusion mutants 0.7305427149461127 1.5663083499191977 0.1172764471555931 1.0 0.493983829424471 5 O95684,P40763 2 +Interferon gamma signaling 0.6132191568383588 1.5636557152039503 0.1178984429605902 1.0 0.4944248988918722 9 P19474,Q14258,Q06124 3 +Interleukin 12 signaling 0.4629466307289315 1.544667623149306 0.1224266801034654 1.0 0.5006985895253185 26 P14174,Q99439,O14979,P04179,Q13177,Q9UL46,Q00169,P60953,P11233,Q13126 10 +Smooth muscle contraction 0.6087461959642404 1.5418815118760998 0.123102389429536 1.0 0.5019081988778304 9 Q13177,Q05682,Q9Y490,P04083 4 +Diseases associated with n glycosylation of proteins 0.9155237026727114 1.5357993329063644 0.1245876033976571 1.0 0.5032726556503722 3 O75340 1 +Organelle biogenesis and maintenance 0.3577164363607621 1.5349043141661884 0.1248073336654052 1.0 0.5032726556503722 70 P48735,A6NIH7,Q8TAG9,Q13409,Q92973,O95684,Q9BW83,P04179,O00471,Q15691 10 +Mitotic metaphase and anaphase 0.3154671536842102 1.5168844005054836 0.1292958727834754 1.0 0.5111526859513883 116 O43633,Q92530,Q92973,Q16763,P48556,Q9Y6G9,Q9UJX4,Q13200,P63151,O43264,O43683,P25789,P30260,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,O43237,Q14974,P14635,Q99436,P06493,Q9Y2U8,P35998,P51665,Q86XL3,Q9BUF5,P68371,Q9Y266,P62191,Q9P258,Q7Z460,P20618,Q13409,Q8N3U4,Q9UN37,O43242,Q15691,Q8NFH4,Q9UJX2,P60900,Q15008,Q06323,P30153 49 +Cilium assembly 0.4024103092578602 1.5153505087726669 0.1296836636178588 1.0 0.5111526859513883 42 Q13409,A6NIH7,Q8TAG9,Q92973,O95684,Q9BW83,O00471,Q15691 8 +Hdr through single strand annealing ssa 0.5538929625913751 1.510162327422675 0.1310020088308841 1.0 0.5111526859513883 13 Q9UQ84,P15927,Q92547 3 +Homologous dna pairing and strand exchange 0.5538929625913751 1.510162327422675 0.1310020088308841 1.0 0.5111526859513883 13 Q9UQ84,P15927,Q92547 3 +Hdr through homologous recombination hrr 0.4948267991179667 1.5079097459439752 0.1315776279547953 1.0 0.5112177839067196 19 Q9UQ84,P15927,P41440,Q92547 4 +Cytoprotection by hmox1 0.3780037559530411 1.5056670826965717 0.1321526581996519 1.0 0.5119462213540769 58 P48556,Q13200,P25789,P25787,P49721,Q86X55,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P40763,P60900,Q15008,Q06323,Q92530 21 +Ephb mediated forward signaling 0.5803913625036327 1.4843168332384626 0.1377248866209082 1.0 0.5165111173425555 10 O15143,O15144,P59998,P61586,Q92747 5 +Signaling by pdgf 0.7103152578119685 1.4816801100360355 0.1384254318813564 1.0 0.5165111173425555 5 P40763,Q06124 2 +Downstream signal transduction 0.7103152578119685 1.4816801100360355 0.1384254318813564 1.0 0.5165111173425555 5 P40763,Q06124 2 +Signaling by egfr 0.6505530520278527 1.4808610252580587 0.1386436107066322 1.0 0.5165111173425555 7 P42566,Q13685,P62993,Q99961,P60953,Q06124 6 +Cargo trafficking to the periciliary membrane 0.5322122052504481 1.4803720904937083 0.1387739739896432 1.0 0.5165111173425555 15 A6NIH7,Q8TAG9 2 +Signaling by leptin 0.8830744071954213 1.4580997605979993 0.1448130473822604 1.0 0.5165111173425555 2 P40763 1 +Interleukin 37 signaling 0.8830744071954213 1.4580997605979993 0.1448130473822604 1.0 0.5165111173425555 2 P40763 1 +Deubiquitination 0.349199386643403 1.456335476213084 0.1452999030158568 1.0 0.5165111173425555 78 P48556,Q9NXR7,Q13200,P61586,P25789,Q8TEY7,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P54727,Q14258,O00231,Q99436,Q8NB78,P51665,P20618,O43242,Q86UV5,P60900,Q15008,Q06323,Q92530 26 +Cellular response to chemical stress 0.3505231977294063 1.449522916476804 0.147191605293254 1.0 0.5165111173425555 67 P48556,P04179,Q13200,P25789,P25787,P49721,Q86X55,Q99460,P28072,P28074,Q9UL46,P28070,Q99436,P63208,P51665,P20618,O43242,P40763,P60900,Q15008,Q06323,Q92530 22 +Interleukin 15 signaling 0.8793949304987738 1.4431755193766571 0.1489710338436884 1.0 0.5165111173425555 2 P40763 1 +Downstream signaling of activated fgfr1 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Tie2 signaling 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Signal regulatory protein family interactions 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Stat5 activation downstream of flt3 itd mutants 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Pi 3k cascade fgfr1 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Activated ntrk2 signals through frs2 and frs3 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Downstream signaling of activated fgfr4 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Pi 3k cascade fgfr3 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Frs mediated fgfr3 signaling 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Frs mediated fgfr2 signaling 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Frs mediated fgfr4 signaling 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Downstream signaling of activated fgfr3 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Pi 3k cascade fgfr4 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Signaling by flt3 itd and tkd mutants 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Downstream signaling of activated fgfr2 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Stat5 activation 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Pi 3k cascade fgfr2 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Frs mediated fgfr1 signaling 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.5165111173425555 2 Q06124 1 +Rhoa gtpase cycle 0.4110525945269816 1.4276285037705738 0.1533988148489764 1.0 0.5275017245819358 37 Q15904,P61586,Q9UDY2 3 +Glutathione synthesis and recycling 0.6947525548293108 1.4163266442188422 0.156679890301326 1.0 0.5311396451642934 5 Q9UJ14 1 +Diseases of mitotic cell cycle 0.6052167350667489 1.395827831740294 0.1627663471270199 1.0 0.536560222411212 8 Q9UJX2,Q16763,Q9UJX4,P11802 4 +Mismatch repair 0.5992741753403399 1.3678697465655942 0.1713528510520596 1.0 0.556091361523901 8 Q9UQ84,P15927 2 +Fanconi anemia pathway 0.6832257093569016 1.3678152039581843 0.17136992739945 1.0 0.556091361523901 5 Q9BXW9,Q9NVI1,P15927 3 +Mtor signalling 0.557010555483063 1.3657566939370482 0.1720153430927111 1.0 0.556091361523901 10 Q96B36,Q04637,Q9Y376,P23588,P54619,P06730 6 +Grb2 sos provides linkage to mapk signaling for integrins 0.8601798855273918 1.365252727351581 0.1721736312363933 1.0 0.556091361523901 2 P62993 1 +Clathrin mediated endocytosis 0.3853190214083308 1.356982168037741 0.1747868765461713 1.0 0.5584016159517399 42 Q9NVZ3,Q9UNS2,Q92905,P20645,Q8N6T3,O15144,P42566,P09497,P62993,Q14247,Q99961,P59998,P61201,P53680,Q14C86,Q9UBW8,P50570,Q99627,P20339,Q96D71,Q92747 21 +Apc c cdc20 mediated degradation of cyclin b 0.595778124428319 1.3514088143619654 0.1765645118166143 1.0 0.5610815716487048 8 P14635,P30260,Q16763,Q9UJX2,Q9UJX4 5 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.6384143600536978 1.336134487754362 0.1815053192902298 1.0 0.5669390530338179 6 Q9UJX2,Q16763,Q9UJX4 3 +Insulin receptor signalling cascade 0.6755035216466495 1.3352773067183477 0.1817856030981628 1.0 0.5669390530338179 5 P62993,Q06124 2 +Eph ephrin signaling 0.4467578386553409 1.334648801794662 0.1819913176102914 1.0 0.5669390530338179 23 P35579,P09497,P60953,P35580,O15143,O15144,P59998,P61586,P53680,Q92747 10 +Semaphorin interactions 0.4972755932446082 1.3263980815826455 0.1847078739123389 1.0 0.5669390530338179 16 P35579,Q13177,P35580,O14786,Q00535,Q9Y490,P61586 7 +Vxpx cargo targeting to cilium 0.6728955831002656 1.3242830891522108 0.1854090446828542 1.0 0.5669390530338179 5 Q8TAG9 1 +Costimulation by the cd28 family 0.5639922543551878 1.322618027165475 0.1859624361649114 1.0 0.5669390530338179 9 P62993,Q13177,Q14738,P60953,P30153,Q06124 6 +Diseases of dna repair 0.5637149625230772 1.3212535343263736 0.1864168415386151 1.0 0.5669390530338179 9 Q9UQ84,P51530 2 +Protein ubiquitination 0.4516094426018969 1.3201119800403962 0.1867976335167016 1.0 0.5669390530338179 21 P61088,Q5VTR2,P68036,Q16763,P45974,P61086,Q14527,Q6PD62,Q9BUN8,A0AVT1,Q93008,Q6P1J9,P22314 13 +Cellular response to heat stress 0.372109201031506 1.3191172938626516 0.1871299024134445 1.0 0.5669390530338179 51 Q96B36,P04792,Q8NFH4,P25685,P15927,Q02790 6 +Negative regulators of ddx58 ifih1 signaling 0.6342100191787551 1.3177022450422482 0.18760334273147 1.0 0.5669390530338179 6 Q13526,Q96J02 2 +Signaling by csf3 g csf 0.6331364910294661 1.3129944757174214 0.1891848096706261 1.0 0.5669390530338179 6 P62993,P40763,Q06124 3 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.7296440331487415 1.306274562101715 0.1914592044955982 1.0 0.5669390530338179 4 P62993,Q06124 2 +Metabolism of folate and pterines 0.5857650431598457 1.3042187088681758 0.192159022719454 1.0 0.5669390530338179 8 P34896,Q9H2D1,P41440 3 +Rho gtpases activate wasps and waves 0.5163467859807856 1.3040390926060248 0.1922202538207593 1.0 0.5669390530338179 13 Q9UQB8,P62993,O15143,O15144,P59998,Q92747 6 +Striated muscle contraction 0.7275899449733443 1.298063945516653 0.1942653623634995 1.0 0.5669390530338179 4 Q9NYL9,P35609 2 +Senescence associated secretory phenotype sasp 0.492136286861199 1.2959630530268111 0.1949882142147299 1.0 0.5669390530338179 16 P11802,Q9H9B1,Q16763,P40763,Q9UJX4,Q9UJX2,Q15418 7 +Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.5831354897034322 1.2918171506339269 0.196420474483022 1.0 0.5669390530338179 8 Q16763,P45974,P68036,A0AVT1,Q93008,P22314 6 +Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.3718662251615527 1.2911870949213595 0.1966388089283275 1.0 0.5669390530338179 49 P60228,Q7L2H7,P55884,P56537,P23588,P62861,O75822,Q9Y262,P05198,P60842,Q04637,O15372,P06730 13 +Parasite infection 0.4992328589703019 1.2903713320813306 0.1969217608095932 1.0 0.5669390530338179 15 P35579,Q9UQB8,P62993,O15143,O15144,P59998,Q92747 7 +Cyclin d associated events in g1 0.6081118517070411 1.2893437805776862 0.1972785968797414 1.0 0.5669390530338179 7 P63208,P63151,P11802,P30153 4 +Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.8409648405560143 1.2874299794392066 0.1979444606097471 1.0 0.5669390530338179 2 P61586 1 +Signaling by ntrk2 trkb 0.8482617586912029 1.28506319860381 0.1987702003750118 1.0 0.5669390530338179 3 P62993,Q06124 2 +Metabolic disorders of biological oxidation enzymes 0.7231695636424782 1.280394059244642 0.200406582247242 1.0 0.5669390530338179 4 P22570 1 +Small interfering rna sirna biogenesis 0.8465711855916653 1.278762279490936 0.2009807807406551 1.0 0.5669390530338179 3 Q9UPY3 1 +Interleukin 20 family signaling 0.8464091682282575 1.2781584701648192 0.2011935560354523 1.0 0.5669390530338179 3 P40763 1 +Interleukin 6 family signaling 0.8464091682282575 1.2781584701648192 0.2011935560354523 1.0 0.5669390530338179 3 P40763 1 +Interleukin 6 signaling 0.8464091682282575 1.2781584701648192 0.2011935560354523 1.0 0.5669390530338179 3 P40763 1 +Cargo concentration in the er 0.5535892010010125 1.271399070287062 0.2035867132188253 1.0 0.5669390530338179 9 Q5JRA6 1 +Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.8427281866331657 1.264442373981353 0.2060712918661185 1.0 0.5669390530338179 3 P40763 1 +Interleukin 2 family signaling 0.8427281866331657 1.264442373981353 0.2060712918661185 1.0 0.5669390530338179 3 P40763 1 +Signaling by kit in disease 0.8427281866331657 1.264442373981353 0.2060712918661185 1.0 0.5669390530338179 3 P40763 1 +Processing of dna double strand break ends 0.4398206093189046 1.2617953188516415 0.207022447060893 1.0 0.5669390530338179 22 Q9UQ84,Q92547,P15927,Q9NXR7 4 +Biosynthesis of specialized proresolving mediators spms 0.8414978288012439 1.2598588406492397 0.2077202889238212 1.0 0.5669390530338179 3 P34913 1 +Egfr downregulation 0.7172667757774088 1.256798928022595 0.2088264543312417 1.0 0.5687829817970521 4 P62993,P42566,P60953 3 +Synthesis of leukotrienes lt and eoxins ex 0.8303352412101415 1.2444637683897528 0.2133289261105462 1.0 0.5780374285204999 2 P09960 1 +Inhibition of replication initiation of damaged dna by rb1 e2f1 0.617276270624559 1.243397857775358 0.2137212593146471 1.0 0.5780374285204999 6 P49642,P09884,P06400,P30153 4 +Phosphorylation of the apc c 0.5475252283170537 1.2415244637909022 0.2144120665973088 1.0 0.5780374285204999 9 P14635,P30260,Q16763,Q9UJX2,Q9UJX4 5 +Gpvi mediated activation cascade 0.712833614914942 1.2390805164693357 0.2153156816234895 1.0 0.57929127377725 4 P61586 1 +Signaling by pdgfr in disease 0.7053722174050043 1.209267655071668 0.2265600330313324 1.0 0.597376853561657 4 P62993,P40763 2 +Glycogen synthesis 0.7031395854605677 1.2003499727086169 0.2300034493438176 1.0 0.6029541042310504 4 P13807,P36871 2 +Recycling of eif2 gdp 0.5884356292077368 1.2002440718817422 0.230044563612755 1.0 0.6029541042310504 7 Q9NR50,Q9UI10 2 +Activation of the pre replicative complex 0.496055152053482 1.1921835149837614 0.2331892958342356 1.0 0.6087807505870065 13 P27694,P33991,P49642,Q07864,P33993,P25205,P09884,P15927 8 +Intra golgi and retrograde golgi to er traffic 0.328024471303758 1.1848559246516157 0.2360744165150987 1.0 0.6138864256229241 69 O60664,P52732,Q5VZE5,P35606,Q13409,P40616,Q14203,Q9BVK6,P20645,Q8N6T3,Q9Y6G9,Q15042,P83436 13 +Flt3 signaling in disease 0.6975346944035957 1.1779709427829317 0.2388081905285042 1.0 0.6197637089814686 4 P62993,Q06124 2 +Interleukin 4 and interleukin 13 signaling 0.5046281236776536 1.174552503256534 0.240173795020278 1.0 0.6197637089814686 11 P04083 1 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.5804858558423871 1.1642453042153422 0.2443246152614331 1.0 0.6254899549619247 7 Q16763,Q9UJX2 2 +Pkmts methylate histone lysines 0.4899813343159449 1.158704458082498 0.2465766730359671 1.0 0.6274028740842285 13 Q9H7B4,O15047 2 +Mastl facilitates mitotic progression 0.6334122096750086 1.157736440327446 0.2469716082693405 1.0 0.6274028740842285 5 P14635,O43768,P30153 3 +Homology directed repair 0.3938086750948204 1.1468941589805923 0.2514253670452899 1.0 0.6314313875795209 32 P41440,Q9UQ84,Q9NXR7,Q92547,P15927 5 +Dna replication initiation 0.6873977086743006 1.1375358359961696 0.255314352499467 1.0 0.6320050681171466 4 P49642,P09884,Q07864 3 +Esr mediated signaling 0.3856414464823914 1.1257135917531074 0.2602867687892694 1.0 0.6320050681171466 34 Q13451,Q99873,P04792,Q02790 4 +Negative regulation of fgfr2 signaling 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Signaling by fgfr3 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Signaling by fgfr1 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Negative regulation of fgfr4 signaling 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Spry regulation of fgf signaling 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Negative regulation of fgfr3 signaling 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Signaling by fgfr4 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Negative regulation of fgfr1 signaling 0.6255911565362676 1.1247864667733158 0.2606795305498863 1.0 0.6320050681171466 5 P62993,Q06124 2 +Pi3k akt signaling in cancer 0.5717134531574616 1.1245452029755871 0.2607818053141792 1.0 0.6320050681171466 7 Q96B36,Q06124 2 +Nephrin family interactions 0.5691250803837082 1.112838884846808 0.265777631723413 1.0 0.6406792910704903 7 Q01082,P12814,Q13813,Q9Y5K6,P35609 5 +Release of apoptotic factors from the mitochondria 0.7959934587080969 1.10637440123951 0.2685645006935568 1.0 0.6428843731429466 2 Q9NR28 1 +Host interactions of hiv factors 0.3161503855710951 1.1050582681703724 0.2691343418107148 1.0 0.6428843731429466 88 P48556,Q13200,P25789,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P53680,Q99436,P43487,P63208,P51665,Q9BXS5,Q93034,P20618,O43747,P17096,O43242,Q8NFH4,P60900,Q15008,Q06323,Q92530 26 +Signaling by robo receptors 0.2947079394122751 1.1046495809232164 0.2693114583160452 1.0 0.6428843731429466 128 P48556,P63173,P62861,O14786,P84098,P23396,Q13200,Q13617,P61586,Q04637,P08865,P25789,P46776,P18077,Q8TEY7,Q01518,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,P61927,P05387,Q99436,P17612,P18124,P35998,P42766,P51665,P60953,P62191,Q7Z460,P20618,O43242,Q13177,O14818,P61513,P60900,P46777,Q15008,P83881,Q06323,Q92530,P39019 48 +Energy dependent regulation of mtor by lkb1 ampk 0.679132293566194 1.1046165347880297 0.2693257833147502 1.0 0.6428843731429466 4 Q9Y376,P54619 2 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.5430792031970455 1.1028345149291074 0.2700990364075211 1.0 0.6428843731429466 8 Q16763,Q9UJX2 2 +Apc cdc20 mediated degradation of nek2a 0.5430792031970455 1.1028345149291074 0.2700990364075211 1.0 0.6428843731429466 8 Q16763,Q9UJX2 2 +Crmps in sema3a signaling 0.6770215521732645 1.0962188213227142 0.2729830248936937 1.0 0.6485801724542616 4 O14786,Q00535 2 +Regulation of hsf1 mediated heat shock response 0.3552679118236659 1.0943849275206403 0.2737861916213402 1.0 0.6493205729475592 45 P04792,Q8NFH4,P25685,P15927,Q02790 5 +Signaling by ntrk3 trkc 0.7963190184048949 1.0921755946418803 0.274755927463326 1.0 0.6499580217614204 3 P62993,Q8WX92 2 +Fgfr1 mutant receptor activation 0.5797798189189116 1.0789302285974651 0.2806188320755343 1.0 0.6579423839696507 6 O95684,P40763 2 +Signaling by fgfr1 in disease 0.5797798189189116 1.0789302285974651 0.2806188320755343 1.0 0.6579423839696507 6 O95684,P40763 2 +Gastrin creb signalling pathway via pkc and mapk 0.6137562674659104 1.0750050643140594 0.2823724609794018 1.0 0.6584354252510318 5 P62993 1 +Purine salvage 0.6706887065601022 1.0710483933449757 0.2841476707082597 1.0 0.6608434383901605 4 P55263 1 +Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0.7833197056418666 1.0558174314178426 0.2910516327642436 1.0 0.6660950455963945 2 Q9Y490 1 +Irs mediated signalling 0.7852760736196234 1.051475096185056 0.2930404414016205 1.0 0.6662761154759738 3 P62993,Q06124 2 +Transcriptional regulation of white adipocyte differentiation 0.5732007059339634 1.0501578906213835 0.2936455263010624 1.0 0.6665047083225145 6 P11802,Q86X55,Q9ULK4 3 +Apoptotic factor mediated response 0.603292679185827 1.031102702856788 0.3024926604573628 1.0 0.6818989837272632 5 Q9NR28 1 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.5650817417772648 1.014717846844951 0.3102403443396646 1.0 0.693363216731988 6 Q9NR77 1 +Cd28 co stimulation 0.6562162517499568 1.0136967034144784 0.3107274975816327 1.0 0.693363216731988 4 P62993,P60953 2 +Metabolism of nucleotides 0.3552517335911198 1.0049121105174508 0.3149391724282195 1.0 0.6993149824016188 39 Q9H773,Q9NRF8,P55263 3 +Prolactin receptor signaling 0.772079238258524 1.0030547265270493 0.3158344569920144 1.0 0.6993149824016188 3 Q06124 1 +Transcriptional regulation by ventx 0.4718823454358058 1.0021268100774725 0.3162823508226533 1.0 0.6993149824016188 11 Q9UJX2,Q16763,Q9UJX4 3 +Dna double strand break repair 0.3464347807897338 1.00006586589008 0.3172786336783719 1.0 0.6997079717681625 43 P41440,Q9UQ84,Q04323,Q9NXR7,Q92547,P15927 6 +Muscle contraction 0.4059978075867929 0.9946617200492508 0.3199008182609417 1.0 0.7024006893682277 20 Q9NYL9,P30626,Q05682,P04083,Q13177,Q9Y490,P08670,P35609 8 +Mapk3 erk1 activation 0.6469377486415785 0.9770815281540036 0.3285287918210029 1.0 0.7126215664951475 4 P06493,Q06124 2 +Diseases of mismatch repair mmr 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.7154966381370071 2 P43246 1 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.5864119465607752 0.960586171848804 0.3367602842834465 1.0 0.7218613109574238 5 P35609 1 +Trna modification in the nucleus and cytosol 0.4754253139251259 0.9510234371888172 0.3415924784547739 1.0 0.7289881486894287 10 O75648,Q9NWX6,P57081 3 +E2f mediated regulation of dna replication 0.4834635674585289 0.9271766635222332 0.35383481715172 1.0 0.743109369566649 9 P14635,P06493,P49642,P06400,P09884,P30153 6 +Mtorc1 mediated signalling 0.501377052616897 0.9075577585384582 0.3641119205293512 1.0 0.7517019536462051 8 Q96B36,P23588,Q04637,P06730 4 +Cd28 dependent vav1 pathway 0.7456032719836443 0.9068313518030436 0.3644959878158766 1.0 0.7517019536462051 3 P62993,P60953 2 +Hdms demethylate histones 0.5401550965895551 0.9065668759010808 0.3646358849147852 1.0 0.7517019536462051 6 Q8NB78 1 +Flt3 signaling 0.7451696128637653 0.9052674139767404 0.3653237352315395 1.0 0.7517019536462051 3 Q06124 1 +Gab1 signalosome 0.7451696128637653 0.9052674139767404 0.3653237352315395 1.0 0.7517019536462051 3 Q06124 1 +Signaling by ptk6 0.5226834213436645 0.9041422698653432 0.3659199670912283 1.0 0.7517578173056183 7 P11802,P61586,P40763 3 +Ub specific processing proteases 0.3095097735697912 0.8981533734491692 0.3691037873841121 1.0 0.7559474467200187 64 P48556,Q13200,P25789,Q8TEY7,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,O00231,Q99436,P51665,P20618,Q86UV5,O43242,P60900,Q15008,Q06323,Q92530 21 +Sema3a pak dependent axon repulsion 0.5696207652778992 0.8909656253540051 0.3729476117186907 1.0 0.7602836343833186 5 O14786 1 +E3 ubiquitin ligases ubiquitinate target proteins 0.4352913530535989 0.8889776729454462 0.3740150792110763 1.0 0.7603422686035899 14 Q6PD62 1 +The role of nef in hiv 1 replication and disease pathogenesis 0.4490377198279709 0.8830333207756872 0.3772182686534939 1.0 0.7603422686035899 11 Q10567,Q13177,Q9BXS5,P53680,O43747 5 +Deadenylation of mrna 0.4488983898093517 0.8823119368654366 0.3776081430482203 1.0 0.7603422686035899 11 Q9C0C2,P23588,Q04637,Q92600,P06730 5 +Ngf stimulated transcription 0.7385076025058864 0.8812979018680347 0.378156601417531 1.0 0.7603422686035899 3 Q00535 1 +Dna strand elongation 0.3841872322346638 0.8796287630251278 0.3790604518454408 1.0 0.7610013022611357 22 P27694,P33991,P41440,P49642,P51530,P39748,Q9BRT9,P33993,P25205,P09884,P15927 11 +Regulation of tp53 activity 0.33325659223627 0.8781231245524264 0.3798769049574273 1.0 0.7614831433213376 43 Q9H9B1,Q9UQ84,P51530,Q13526,Q8WXI9,O14744,Q92547,Q92804,P15927 9 +Signaling by erbb4 0.564835067605683 0.8712431690681803 0.3836213935938739 1.0 0.7666624219932034 5 P62993,Q96J02,P16949 3 +Unwinding of dna 0.5120187468073485 0.856824461476347 0.3915419046945341 1.0 0.7746453246045926 7 Q9BRT9,P33993,P33991 3 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.362814673097151 0.8552916313392487 0.3923897193118879 1.0 0.7746453246045926 29 P31948,Q13409,Q13451,Q14203,Q9Y6G9,Q9UJW0,Q9BUF5,P25685,P54652,O43237,Q02790 11 +Cargo recognition for clathrin mediated endocytosis 0.3653695324698103 0.852462791031252 0.3939572824209048 1.0 0.7746453246045926 27 Q99627,Q9NVZ3,P42566,Q9UNS2,P62993,Q9UBW8,P20645 7 +Translesion synthesis by polk 0.4889911141503258 0.8502987873445578 0.395158990608432 1.0 0.7746453246045926 8 P41440 1 +Regulation of expression of slits and robos 0.2731626111166759 0.8493910987700274 0.3956637045237237 1.0 0.7746453246045926 118 P48556,P63173,P62861,P84098,Q13200,Q04637,P25789,Q8TEY7,P25787,P49721,Q99460,P28072,P28074,Q9UL46,P28070,P61927,P05387,Q99436,P51665,P20618,O43242,P60900,P46777,Q15008,P83881,Q06323,Q92530 27 +Regulation of tp53 activity through phosphorylation 0.364798706505107 0.8482553528408419 0.3962957764015264 1.0 0.7746453246045926 27 Q9UQ84,Q13526,Q92547,Q92804,P15927 5 +Endosomal sorting complex required for transport escrt 0.5240334238396652 0.8373686604546986 0.4023853760411615 1.0 0.7776784747050048 6 Q99816,O43633 2 +Sphingolipid de novo biosynthesis 0.4521408180225646 0.8345616342454732 0.403964571192114 1.0 0.7790324066347192 10 Q06136 1 +Extracellular matrix organization 0.3686705866208207 0.8288914525109228 0.4071658324720739 1.0 0.7793032103922602 25 Q9Y624,P20810,P11047,P07384,P35613,O60568,P17655,O75718,O15460 9 +Ros and rns production in phagocytes 0.5041146645735677 0.8219768787973456 0.4110900561720139 1.0 0.7813166021210639 7 P21281,Q9Y487,Q93050,Q9UI12 4 +Collagen biosynthesis and modifying enzymes 0.4369979127689841 0.8209845375585334 0.4116550757579564 1.0 0.7813166021210639 11 O60568,O15460 2 +Nef mediated downregulation of mhc class i complex cell surface expression 0.6033822949750338 0.8075962668683699 0.4193230364841362 1.0 0.7889106101673016 4 Q9BXS5,O43747 2 +Dna damage recognition in gg ner 0.4203333143454531 0.806704748267886 0.4198366078331665 1.0 0.7889106101673016 14 Q99627,Q9UNS2,Q9UBW8,Q92905,P54727,P61201 6 +Ret signaling 0.7104294478527456 0.7816011866352627 0.4344489893083867 1.0 0.794221008196557 3 P62993,Q06124 2 +Recruitment of mitotic centrosome proteins and complexes 0.3669208779985218 0.7790137927277709 0.4359715899249701 1.0 0.794221008196557 23 P06493,P61981,P17612,Q13409,Q14203,O95684,Q15691,O75935,P68371,Q7Z460,P30153 11 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.5957446808510591 0.7784215843903906 0.4363205182457736 1.0 0.794221008196557 4 Q14738,P30153,P17612 3 +Ctla4 inhibitory signaling 0.59574468085105 0.7784215843903551 0.4363205182457945 1.0 0.794221008196557 4 Q14738,P30153,Q06124 3 +G2 m dna damage checkpoint 0.3509949185617957 0.7783762353929687 0.4363472444438208 1.0 0.794221008196557 30 Q9UQ84,Q92547,P15927,Q9NXR7 4 +Formation of incision complex in gg ner 0.4728237591581379 0.7763692248441668 0.4375310102593766 1.0 0.794221008196557 8 P27694,P15927,P54727 3 +G2 m dna replication checkpoint 0.7109566639411329 0.7747193510132151 0.4385055138746008 1.0 0.794221008196557 2 P14635 1 +Chromatin modifying enzymes 0.3083091417473454 0.7738663734420886 0.4390098168201866 1.0 0.794221008196557 58 P11802,Q9H9B1,Q9Y2K7,P61964,Q8NB78,Q8WXI9,Q99873,Q12824,O14744,Q9H7B4,O60678,O15047,Q15014 13 +Dna repair 0.2910596690068223 0.772714472182334 0.4396913798349642 1.0 0.794221008196557 85 Q99627,P27695,P41440,Q6P6C2,Q9UQ84,Q9UBW8,P51530,Q04323,Q9BXW9,Q9NXR7,Q9C0B1,P54727,Q92547,P43246,Q9NVI1,P15927 16 +Cd209 dc sign signaling 0.710139002452989 0.771645518810811 0.4403244067535823 1.0 0.794221008196557 2 Q13177 1 +Response of eif2ak1 hri to heme deficiency 0.707438739610428 0.7711265627671104 0.4406319173714217 1.0 0.794221008196557 3 P05198 1 +Interleukin 3 interleukin 5 and gm csf signaling 0.5398001017858347 0.7691889078562573 0.4417811742582207 1.0 0.794221008196557 5 P62993,P17612,Q06124 3 +Lipophagy 0.7041701305026373 0.7597142587151854 0.4474254037904535 1.0 0.8008793474352155 3 O60664 1 +P75ntr regulates axonogenesis 0.7007340820347225 0.747758751967323 0.454605686116452 1.0 0.8060860555165547 3 P61586 1 +Rhoc gtpase cycle 0.3569868957575023 0.7467117074594585 0.4552376012500101 1.0 0.8061244922939188 25 P61586,Q9UDY2 2 +Mitochondrial biogenesis 0.348706074165767 0.739439521636109 0.4596401511063512 1.0 0.8117441706035963 28 P48735 1 +Er to golgi anterograde transport 0.2995239100689196 0.7316454427322334 0.4643850040731156 1.0 0.816847656964828 61 Q14789,Q92734,Q14203,Q8N6T3,Q9Y6G9,Q5JRA6,O60763,Q9UJW0,Q9Y296,O43237,P35606,P18085,O95486,P49257,O75935,Q9BUF5,P68371,P83436,P61923,Q5H9R7,Q13409,Q9UBF2,Q9Y678,Q9BVK6,Q15436,P53621 26 +Signaling by tgfb family members 0.3794378894609422 0.7189702523393011 0.4721592487714758 1.0 0.8238732245721708 18 Q7Z3T8,Q9Y624,Q9UPN9,Q9Y5K5,P61081,P61586,Q9Y3F4 7 +Signaling by met 0.4087170083949236 0.7184814225515597 0.4724604984972129 1.0 0.8238732245721708 13 P42566,P62993,P11047,P40763,Q06124 5 +Cholesterol biosynthesis 0.4081502493932363 0.7155165830951496 0.4742898976280048 1.0 0.8238732245721708 13 Q15392 1 +Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.6946034341782552 0.713824681665023 0.4753355955554785 1.0 0.8238732245721708 2 P06493 1 +Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.4264856235427641 0.708946169048679 0.4783578828515178 1.0 0.8238732245721708 10 Q9BXS5,O43747,P53680,Q10567 4 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.6913327882256797 0.701801671081781 0.4828028564997417 1.0 0.8293661553136006 2 P11802 1 +Pentose phosphate pathway 0.4757821268318845 0.6990819814922747 0.4845007983930722 1.0 0.8301239360275596 7 Q96G03,P11413,O95336 3 +Collagen formation 0.4039042736568709 0.6933813938708883 0.4880702355677413 1.0 0.8331869663652167 13 O60568,O15460 2 +Integrin cell surface interactions 0.6848731889836521 0.6931629183207475 0.488207316241863 1.0 0.8331869663652167 3 P35613 1 +Nervous system development 0.2858232970858424 0.6806588265983713 0.4960873947106434 1.0 0.8404644150149394 190 P48556,P63173,P62861,O14786,O15144,P84098,O15143,Q13200,P61586,Q04637,P25789,Q06124,P35579,Q8TEY7,P09497,Q01518,P62993,P25787,P49721,P35241,Q99460,P28072,P28074,Q9UL46,P28070,P59998,Q00169,Q9NR77,P53680,P61927,O95372,P05387,P15311,Q99436,P51665,Q9BUF5,Q9Y490,P50570,P20618,Q96S59,O43242,P11047,P60900,Q00535,P46777,Q15008,Q15418,P83881,Q06323,Q92530,Q92747 51 +Membrane trafficking 0.28484891559141 0.680300607985506 0.4963141396503558 1.0 0.8404644150149394 184 Q14789,Q9NVZ3,O43633,O60664,Q92734,Q9UNS2,Q14203,P20645,O60749,Q8N6T3,P55327,Q9Y6G9,O15144,P11233,Q5JRA6,P33176,P35579,P42566,Q5VZE5,P09497,Q8TAG9,Q04917,O60343,Q14247,P40616,P62993,Q8IWJ2,Q9Y5X3,Q9UJW0,Q9Y296,P59998,P61201,P54619,Q8TC07,P53680,O43237,P52732,P35606,P18085,Q99816,Q9UBW8,Q9BUF5,Q15042,Q9UIQ6,Q9BXS5,P50570,P83436,O43747,Q99627,Q13409,P20339,Q9UN37,Q9BVK6,O00471,Q15436,Q92747 56 +Rora activates gene expression 0.6852003270646007 0.6794098939921792 0.4968781826162307 1.0 0.8404644150149394 2 Q86X55 1 +Fceri mediated mapk activation 0.5685392407686909 0.6763281057928521 0.4988323520393782 1.0 0.8404644150149394 4 P62993 1 +Raf independent mapk1 3 activation 0.516383671835548 0.6759238744276056 0.4990889788335426 1.0 0.8404644150149394 5 P06493,Q06124 2 +Budding and maturation of hiv virion 0.4696167021711233 0.6728540316998882 0.5010401592570144 1.0 0.8404644150149394 7 Q99816,O43633,Q9UN37 3 +Eukaryotic translation initiation 0.2742859199756823 0.6646465543969137 0.506276585356779 1.0 0.8404644150149394 99 P60228,Q7L2H7,P63173,P62861,O75822,P84098,Q04637,P56537,P23588,Q9Y262,P61927,P55010,P05387,P06730,P55884,P05198,P60842,O15372,Q9UI10,Q9NR50,P61513,P46777,P83881 23 +Regulation of runx1 expression and activity 0.6763782100671858 0.6643568110141135 0.50646196818832 1.0 0.8404644150149394 3 Q06124 1 +Er quality control compartment erqc 0.6798855273916655 0.6601704350690502 0.5091444626053903 1.0 0.8428318735610533 2 Q9UBV2 1 +Caspase mediated cleavage of cytoskeletal proteins 0.5638669366245173 0.6591272628994334 0.509814050093029 1.0 0.8428840552852207 4 P08670,Q15149 2 +Runx1 regulates transcription of genes involved in differentiation of myeloid cells 0.6786590351594497 0.6557533622065941 0.5119828284641268 1.0 0.8454116455013894 2 P17931 1 +Fcgamma receptor fcgr dependent phagocytosis 0.3584189323504041 0.637101316149896 0.5240588513221982 1.0 0.8578460255224584 19 P35579,Q9UQB8,P62993,O15143,O15144,P59998,Q92747 7 +Cell surface interactions at the vascular wall 0.3993390952891673 0.6321087702154817 0.5273158047711577 1.0 0.8618389332743024 11 P62993,P14174,Q06124,P35613 4 +Translocation of slc2a4 glut4 to the plasma membrane 0.3426232779196144 0.6313633866045762 0.5278029500521655 1.0 0.8618389332743024 24 P35579,Q8TAG9,O60343,Q04917,O00471,Q9BUF5,Q9UIQ6,P11233 8 +Uptake and function of anthrax toxins 0.6700735895339387 0.6250836922692149 0.5319161304617945 1.0 0.8653463156896929 2 Q8WUM4 1 +Map2k and mapk activation 0.4185233891881182 0.6207181261151794 0.5347851010174638 1.0 0.8657489196618501 9 Q02750,P18206,Q9Y490,P41240,P30086 5 +Nucleotide biosynthesis 0.392561477260663 0.6156187989376701 0.538146141047859 1.0 0.866812362810021 12 P22102,P49915,P30520,Q05682,P11172,O15067,P30566,P27708 8 +Translesion synthesis by polh 0.3918319282468271 0.5957445784482053 0.551345872862322 1.0 0.8743432149473317 11 P41440 1 +Erks are inactivated 0.4503759241250951 0.5925041002343578 0.553513075902816 1.0 0.8754145017890027 7 P51452,Q14738,P30153,Q8IV63 4 +Downregulation of smad2 3 smad4 transcriptional activity 0.4895096294711563 0.5724516605792029 0.5670160256571919 1.0 0.8871826194868945 5 Q9UPN9,Q13547 2 +Signaling by tgf beta receptor complex 0.3606493706710346 0.5717352157759962 0.5675013727982028 1.0 0.8871826194868945 17 Q9Y624,Q9UPN9,Q9Y5K5,P61081,P61586,Q9Y3F4 6 +Signaling by flt3 fusion proteins 0.6475847367081176 0.5693515847804522 0.5691175660756933 1.0 0.8879852155404889 3 P62993 1 +Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.3828624257908776 0.568062733520937 0.569992371324 1.0 0.8879852155404889 12 O15047,P61964 2 +Cytosolic sulfonation of small molecules 0.6448116414817812 0.5604406060293753 0.5751789411199439 1.0 0.8937089934704197 3 O95861 1 +Pd 1 signaling 0.6492232215862699 0.5525793847826921 0.5805514615468548 1.0 0.8954857097891481 2 Q06124 1 +Regulated necrosis 0.3690973386569208 0.5370208988332836 0.591253178244497 1.0 0.8981972001823538 14 P41440 1 +Cyclin a b1 b2 associated events during g2 m transition 0.4350390563783298 0.5303779515420739 0.5958499098404091 1.0 0.9020820130052888 7 P14635,P63151,P30153 3 +Anchoring of the basal body to the plasma membrane 0.3263591392313681 0.5134397087341037 0.6076437749379129 1.0 0.9100877853661936 23 P06493,P61981,P17612,Q13409,Q14203,O95684,Q15691,O75935,P68371,Q7Z460,P30153 11 +Late endosomal microautophagy 0.4297851954562314 0.5095499890335108 0.610366768338996 1.0 0.9118516098904078 7 O60664,O43633,Q99816 3 +Biological oxidations 0.2972591676768883 0.5088002281612961 0.6108922594648076 1.0 0.9118516098904078 39 Q99707,P22570,P30837,P28161,Q969Z3 5 +Rhou gtpase cycle 0.367594683559335 0.495332215423407 0.6203656341229322 1.0 0.9170436220408344 12 Q01082,P62993,Q13813,O43396,Q13177,P60953,Q93008,P46940 8 +Rhof gtpase cycle 0.356145441352842 0.4930921826722996 0.6219474541932397 1.0 0.9170436220408344 15 Q02952 1 +Rho gtpases activate paks 0.4057989854963943 0.4863111856099653 0.6267465497363949 1.0 0.9170436220408344 8 P35579,P35580,Q14247,P60953 4 +Non integrin membrane ecm interactions 0.5147457128982507 0.4860710873276158 0.6269167653730632 1.0 0.9170436220408344 4 P11047,Q9Y296 2 +Ncam signaling for neurite out growth 0.4634678084562124 0.4769641016252804 0.6333876846059809 1.0 0.9193346602356356 5 P62993,Q13813 2 +M phase 0.2654964850863905 0.476104535812839 0.6339999057340377 1.0 0.9193346602356356 161 O43633,Q92530,Q92973,Q16763,Q14203,P48556,Q9Y6G9,Q9UJX4,Q13200,P63151,O43264,O43683,O60763,P25789,Q01105,P30260,O43768,P25787,P49721,Q15021,Q99460,P28072,P28074,Q9UL46,P28070,Q9UNM6,O00231,O43237,Q14974,P14635,Q99436,P06493,Q9Y2U8,P17612,P35998,P51665,O75935,Q9NTJ3,Q86XL3,Q9BUF5,P68371,Q9Y266,P62191,Q9P258,Q7Z460,P20618,Q13409,Q8N3U4,O95684,O43242,Q9UN37,Q15691,Q8NFH4,Q9UJX2,P60900,Q15008,Q06323,P30153 58 +Global genome nucleotide excision repair gg ner 0.3100960339073345 0.4737137818953765 0.635704024068614 1.0 0.9197864357005904 29 Q99627,P41440,Q9UBW8,P54727,P15927 5 +Lagging strand synthesis 0.3517987478082187 0.4714789236381959 0.6372987671341968 1.0 0.9203059719887116 15 P41440,P49642,P51530,P39748,P09884,P15927 6 +Processive synthesis on the lagging strand 0.3713979127686349 0.4562468282103531 0.6482124948389667 1.0 0.9291925305723644 10 P27694,P49642,P51530,P39748,P09884,P15927 6 +Negative regulation of mapk pathway 0.3780237802378096 0.4453364542281375 0.6560766272602838 1.0 0.932914127675818 9 P27361,P53041,Q02750,P31946,P30086,Q14738,P30153,P30154 8 +Rmts methylate histone arginines 0.3184184237500535 0.4428536982701691 0.6578715598007874 1.0 0.9344605704267098 20 P61964,Q99873,Q12824,O14744,P11802,O60678 6 +Map3k8 tpl2 dependent mapk1 3 activation 0.6045946228624838 0.4368454122890178 0.6622234624145944 1.0 0.93761757111434 3 P63208 1 +Runx2 regulates bone development 0.4496357161661193 0.4286052869205956 0.6682104973808616 1.0 0.9410512441792304 5 Q96PK6,P06400 2 +Maturation of sars cov 2 nucleoprotein 0.4466773838723228 0.4185024033192279 0.675579829759795 1.0 0.949405271396478 5 Q99873,P78362 2 +Tp53 regulates transcription of dna repair genes 0.3124838846268775 0.4144036248648328 0.6785785346843622 1.0 0.9520408376796112 21 Q8WX92,Q9BXW9,Q9H3P2,Q08945,O00267,Q9NYV4,P43246,Q9NVI1 8 +Metabolism of water soluble vitamins and cofactors 0.3000855320133503 0.4131087673060879 0.6795269262580557 1.0 0.9520408376796112 30 Q99707,P43490,P34896,P41440 4 +Inactivation of csf3 g csf signaling 0.492157352209889 0.4124742594569825 0.6799918437133312 1.0 0.9520408376796112 4 P40763 1 +Pp2a mediated dephosphorylation of key metabolic factors 0.5955010224948872 0.4105407715852204 0.6814093013350262 1.0 0.9520408376796112 3 Q14738,P30153 2 +Rhob gtpase cycle 0.3299099725094927 0.4094930695128547 0.6821778517895773 1.0 0.9520408376796112 17 Q9UDY2 1 +Signaling by ctnnb1 phospho site mutants 0.4160524160524287 0.4080719831721747 0.6832208282515302 1.0 0.9520408376796112 6 P49841,Q14738,P48729,P30153,P30154 5 +Beta catenin phosphorylation cascade 0.4160524160524287 0.4080719831721747 0.6832208282515302 1.0 0.9520408376796112 6 P49841,Q14738,P48729,P30153,P30154 5 +Disassembly of the destruction complex and recruitment of axin to the membrane 0.4160524160524287 0.4080719831721747 0.6832208282515302 1.0 0.9520408376796112 6 P49841,Q14738,P48729,P30153,P30154 5 +Mitotic spindle checkpoint 0.2779106910485063 0.3963111602982683 0.691875495125958 1.0 0.9589461004414792 41 P30260,Q13409,Q16763,P30153,Q9P258,Q15691,Q9Y6G9,Q9UJX4,Q9Y266,Q8NFH4,Q9UJX2,O43264,O43683,Q7Z460,O43237 15 +Vesicle mediated transport 0.2668371377971625 0.3924718217568704 0.6947096276476121 1.0 0.9589461004414792 191 Q14789,Q9NVZ3,O43633,O60664,Q92734,Q9UNS2,Q14203,P20645,O60749,Q8N6T3,P55327,Q9Y6G9,O15144,P11233,Q5JRA6,P33176,P35579,P42566,Q5VZE5,P09497,Q8TAG9,Q04917,O60343,Q14247,P40616,P62993,Q8IWJ2,Q9Y5X3,Q9UJW0,Q9Y296,P59998,P61201,P54619,Q8TC07,P53680,O43237,P52732,P35606,P18085,Q99816,Q9UBW8,Q9BUF5,Q15042,Q9UIQ6,Q9BXS5,P50570,P83436,O43747,Q99627,Q13409,P20339,Q9UN37,Q9BVK6,O00471,Q15436,Q92747 56 +Pcna dependent long patch base excision repair 0.3409567865883837 0.3877768646481001 0.6981811678027288 1.0 0.9607263777785464 13 P27695,P41440,P39748,Q07864,P15927 5 +Condensation of prometaphase chromosomes 0.3616000007308699 0.3797485351556435 0.7041320883735089 1.0 0.9635491168671044 9 P14635,P06493,Q15021,Q9NTJ3,O95347,Q9BPX3 6 +Metabolism of steroids 0.2866743464390202 0.3789020506793399 0.7047606013317804 1.0 0.9635491168671044 36 Q15436,P22570,Q15392,P38435 4 +Runx3 regulates p14 arf 0.5944399018806295 0.3785461356443321 0.7050249277336327 1.0 0.9635491168671044 2 Q13951 1 +Phase i functionalization of compounds 0.3322598871537896 0.3782313610598235 0.7052587301535369 1.0 0.9635491168671044 15 P30837 1 +Assembly of collagen fibrils and other multimeric structures 0.5936222403924857 0.376161016842525 0.706797194734462 1.0 0.9635491168671044 2 Q15149 1 +Type i hemidesmosome assembly 0.5936222403924857 0.376161016842525 0.706797194734462 1.0 0.9635491168671044 2 Q15149 1 +Interferon signaling 0.2672580410209626 0.3706069914653209 0.7109302739089869 1.0 0.9654205255415452 57 Q9Y4X5,Q13526,Q8NFH4,P19474,Q13325,Q04637 6 +Gap junction degradation 0.4052079015454164 0.3703882317718844 0.711093240993129 1.0 0.9654205255415452 6 P09497 1 +Formation of rna pol ii elongation complex 0.3049453192560094 0.3681767636529627 0.7127414352386852 1.0 0.965449382592097 20 Q8WX92 1 +Apoptotic cleavage of cellular proteins 0.3245821864505098 0.3603881554879395 0.7185568829440565 1.0 0.965449382592097 16 Q9UDY2 1 +Signaling by alk in cancer 0.2904516912553926 0.3565574169796381 0.7214231610239215 1.0 0.965449382592097 31 P35579,Q86WB0,Q92734,Q9P2E9,P62993,P10644,Q14203,P63208,P26038,Q9HC35,Q8IWJ2,P18206,Q07866,P40763,P33176 15 +Serine biosynthesis 0.5854456255110467 0.3526956340589757 0.724316632809999 1.0 0.965449382592097 2 O43175 1 +Transcriptional regulation by tp53 0.2507634334473429 0.3523241956923915 0.7245951444819252 1.0 0.965449382592097 95 Q9C0C2,Q9UQ84,P51530,Q9H3P2,Q99873,Q92547,P43246,O00267,Q92600,Q04917,Q86X55,Q13526,Q8WX92,P54619,P30876,Q9H9B1,Q08945,Q9NQ88,Q9NYV4,O95983,P11413,Q8WXI9,Q9BXW9,Q07812,Q00535,O14744,Q9NVI1,Q92804,P15927 29 +Platelet aggregation plug formation 0.472103649732524 0.3511160101370408 0.7255013173131417 1.0 0.965449382592097 4 P62993 1 +Integrin signaling 0.472103649732524 0.3511160101370408 0.7255013173131417 1.0 0.965449382592097 4 P62993 1 +N glycan trimming in the er and calnexin calreticulin cycle 0.3293321595360099 0.3500162540134872 0.7263264993601404 1.0 0.965449382592097 14 Q9BUN8,Q9UBV2,P54727,Q04323 4 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.321986251782076 0.348420888029929 0.7275241177573748 1.0 0.965449382592097 16 P61758,Q9BUF5,O15212,Q99471 4 +Glutathione conjugation 0.3318387747025641 0.348341895343704 0.7275834337594347 1.0 0.965449382592097 13 Q9UJ14,P28161 2 +Transcriptional regulation by mecp2 0.3357674535222597 0.3456470154244916 0.7296080080501426 1.0 0.965449382592097 11 Q14353 1 +Tbc rabgaps 0.3442398899889778 0.3451096514691304 0.7300119378749137 1.0 0.965449382592097 10 Q8TC07 1 +Rhobtb1 gtpase cycle 0.305272055317323 0.3395740755919232 0.7341773038797026 1.0 0.9688793390860012 19 Q5VTR2,Q7Z6E9,O43396,Q8N684,P61201,P08670 6 +Gp1b ix v activation signalling 0.5793131643499678 0.3355683106097192 0.7371964240929316 1.0 0.9718926908450726 2 P63104 1 +Constitutive signaling by aberrant pi3k in cancer 0.465798929576745 0.3326862080114417 0.7393711614976879 1.0 0.9733264604997132 4 Q06124 1 +Cell cell communication 0.2943755539027148 0.3197213890811369 0.7491795440522466 1.0 0.9769998337092732 22 Q01082,Q03001,Q9Y624,P21333,P62993,P12814,Q13813,P35221,Q14315,Q15149,Q9Y5K6,P46940,P35609,Q06124 14 +Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.3777140516181808 0.3191195202166916 0.7496358819362452 1.0 0.9769998337092732 7 P27361,Q13573,Q9UPN9,Q13547,P09874,Q93008 6 +Aryl hydrocarbon receptor signalling 0.5578498081762395 0.3092588914336527 0.7571245990658719 1.0 0.9801833480711803 3 Q15185 1 +Pi metabolism 0.3584806832533857 0.3086562306996918 0.757583041923297 1.0 0.9801833480711803 8 P20339,Q9UBF8,Q99570 3 +Cytosolic trna aminoacylation 0.2895434003326381 0.2990949103681252 0.7648676295797041 1.0 0.9828697847031024 23 P26639,O43776,Q13155,P26640,P41252,Q15046,Q15181,P07814,P49588,P49591,P54577,O43324,P23381 13 +Deadenylation dependent mrna decay 0.2809738649306214 0.2919924401362024 0.7702924041277797 1.0 0.986960490642868 30 Q9C0C2,P26196,P62312,P23588,Q9Y2L1,Q04637,Q92600,Q969T7,P06730 9 +G1 s specific transcription 0.3522055814791662 0.2875219699671391 0.7737126821880662 1.0 0.9894234783837712 8 P09884,P31350,P06493,P00374 4 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.3344408698804079 0.2804233603662169 0.7791527167481695 1.0 0.9946608993086428 9 P14635,P06493,P63104,Q04917 4 +Glycogen metabolism 0.3497913317560623 0.279564259231827 0.7798118310733861 1.0 0.9946608993086428 8 P13807,Q96G03,P36871 3 +Hats acetylate histones 0.3017048538115741 0.2770218966575958 0.7817632927632572 1.0 0.9949029958962068 17 Q15014 1 +Transport to the golgi and subsequent modification 0.250357012883792 0.2746765758953517 0.7835647289227812 1.0 0.9950080521251338 62 Q14789,Q92734,Q14203,Q8N6T3,Q9Y6G9,Q5JRA6,O60763,Q9UJW0,Q9Y296,O43237,P35606,P18085,O95486,P49257,O75935,Q9BUF5,P68371,P83436,P61923,Q5H9R7,Q13409,Q9UBF2,Q9Y678,Q9BVK6,Q15436,P53621 26 +Regulation of tp53 activity through acetylation 0.3231980135686477 0.2675357454965995 0.7890566959034206 1.0 0.9952410428005212 10 Q8WXI9,Q13526 2 +Developmental biology 0.2608735395871083 0.264102854264971 0.7917006645714819 1.0 0.9952410428005212 226 Q9Y2W1,P48556,P63173,P62861,O14786,O15144,P84098,O15143,Q13200,P61586,Q04637,P25789,Q92600,Q06124,P35579,Q8TEY7,P09497,Q01518,P62993,O60271,P25787,P49721,P35241,Q86X55,Q99460,P28072,P28074,Q9UL46,P28070,P59998,Q00169,Q9NR77,P30876,P53680,P61927,O95372,P05387,P15311,Q99436,P61964,P07384,P51665,Q9BUF5,Q9Y490,P50570,P20618,Q15008,Q96S59,Q15418,O43242,P11047,P40763,P60900,Q00535,Q9ULK4,P46777,P11802,P83881,Q06323,Q92530,Q92747 61 +Interferon alpha beta signaling 0.3213681636431802 0.2611911386404553 0.7939451113460558 1.0 0.9952410428005212 10 Q13325 1 +Regulation of plk1 activity at g2 m transition 0.2769248727923466 0.2606676586149833 0.7943488086845383 1.0 0.9952410428005212 27 P14635,P06493,Q13409,P17612,P63208,Q14203,O95684,Q15691,O75935,P68371,P30153 11 +Met activates ptpn11 0.5350424401718429 0.2545867550999088 0.7990422900825043 1.0 0.9952410428005212 3 Q06124 1 +Slc transporter disorders 0.2741145819610662 0.251615889735917 0.8013379754687677 1.0 0.9967678583749926 30 O00400,P35613 2 +Condensation of prophase chromosomes 0.3161388449050847 0.2434366381169711 0.8076671641801012 1.0 0.998057507798323 10 P14635,P06493,Q9NTJ3,P06400,O95347,Q01105 6 +Transcription of the hiv genome 0.2937225118127985 0.2431183359297107 0.8079137272645676 1.0 0.998057507798323 17 Q8WX92,Q08945,Q9H3P2,O00267,Q92804 5 +Signaling by nuclear receptors 0.2566276645562705 0.2392148019806231 0.810939025497498 1.0 0.998682843366989 47 Q13451,P04792,Q8NB78,Q99873,Q02790 5 +Phase ii conjugation of compounds 0.2767738404541437 0.233702396580762 0.8152160270706199 1.0 1.0 23 Q9UJ14,Q99707,P48506,O95861,P28161 5 +Purine ribonucleoside monophosphate biosynthesis 0.3198031980319882 0.2323701031112152 0.8162505677093421 1.0 1.0 9 P22102,P49915,P30520,P12268,P22234,Q06203,O15067,P30566 8 +Termination of translesion dna synthesis 0.3011059641918353 0.2280621427808903 0.8195979302495178 1.0 1.0 13 Q14258,Q07864,P15927,P41440 4 +Met promotes cell motility 0.3590923280098258 0.2275157483374009 0.8200227248982055 1.0 1.0 6 P11047 1 +Signaling by braf and raf1 fusions 0.2799505969534754 0.2206519014994636 0.825363485356384 1.0 1.0 19 P27361,Q9NRY5,Q96PU8,Q02750,P51114,O00203,P31946,Q7Z2W4,O43252,Q7KZF4,P18206,Q6WCQ1,P28482,Q9Y490,P41240,P46940,P30086,P02545 18 +Suppression of phagosomal maturation 0.3806370417701715 0.2199132997007179 0.8259386781923228 1.0 1.0 5 P20339,Q14974 2 +Cell cell junction organization 0.3453502662843072 0.2194715767299765 0.8262827186219537 1.0 1.0 7 Q9Y624,P55196,P19022,P35221,O60716,P35222 6 +Vegfr2 mediated vascular permeability 0.3453502662843063 0.2194715767299736 0.8262827186219559 1.0 1.0 7 P07900,P42345,P35221,Q13177,O60716,P35222 6 +Nuclear events kinase and transcription factor activation 0.297222794734614 0.2144160210217501 0.8302226492080687 1.0 1.0 13 Q15418,P51452,Q00535,P50570 4 +Foxo mediated transcription 0.3266690527709532 0.2085533570728701 0.8347969254673244 1.0 1.0 8 Q13547,P63104,P04179 3 +L1cam interactions 0.2631571184131783 0.2077432789805962 0.8354294230591996 1.0 1.0 34 P15311,Q96S59,Q16555,Q02750,P26038,P35241,P11047,O14786,Q9BUF5,P68371,P50570,Q15418,P53680,O95372 14 +Recognition of dna damage by pcna containing replication complex 0.2941970375214656 0.2040443775162578 0.8383188200921103 1.0 1.0 13 P41440 1 +Mrna decay by 5 to 3 exoribonuclease 0.3736623113708263 0.2024264758696416 0.8395833320620651 1.0 1.0 5 P62312 1 +Activation of bad and translocation to mitochondria 0.3493038493038494 0.2013293122383055 0.8404410839381111 1.0 1.0 6 P61981,Q04917,P31946,P27348,P63104 5 +Sulfur amino acid metabolism 0.3377009414612401 0.1984586593762505 0.8426862264456028 1.0 1.0 7 Q99707 1 +Gap filling dna repair synthesis and ligation in gg ner 0.2923835503326942 0.1979395869958891 0.843092330949399 1.0 1.0 13 P41440 1 +Translation of replicase and assembly of the replication transcription complex 0.5061287114653507 0.1933586269899202 0.8466781148247429 1.0 1.0 3 O43633 1 +Sensory processing of sound by outer hair cells of the cochlea 0.3055826287621399 0.1898043663110525 0.8494624342735824 1.0 1.0 9 P35579,P15311,P26038,P35241,Q13813 5 +Abortive elongation of hiv 1 transcript in the absence of tat 0.2976617354692255 0.1853990841695358 0.8529160266961096 1.0 1.0 10 Q8WX92,O00267,Q9H3P2 3 +Formation of the early elongation complex 0.2904816611782929 0.1839958917146824 0.8540166778388407 1.0 1.0 11 Q8WX92,O00267,Q9H3P2 3 +Regulation of tp53 activity through methylation 0.3652238419644201 0.1822719587572502 0.8553693037115093 1.0 1.0 5 O14744 1 +Dual incision in gg ner 0.2834243591864455 0.1811107274461427 0.8562806645570955 1.0 1.0 15 P41440 1 +Negative regulation of the pi3k akt network 0.3010876604018324 0.1772394652376295 0.8593202975779877 1.0 1.0 9 Q06124 1 +Tp53 regulates transcription of cell cycle genes 0.2863366700170771 0.1741704831276988 0.8617314820149438 1.0 1.0 12 Q9C0C2,Q86X55,Q07812,Q99873,Q92600 5 +Dag and ip3 signaling 0.3986191603116018 0.1663724634109921 0.8678638429414556 1.0 1.0 4 P10644 1 +Met activates ras signaling 0.3978373726544437 0.1647919836086014 0.8691077139313876 1.0 1.0 4 P62993 1 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.2779742339791392 0.1629698396541598 0.8705421816331682 1.0 1.0 15 P27695,P41440,P39748,Q07864,P15927 5 +Regulation of localization of foxo transcription factors 0.3956628477905048 0.1604414726540846 0.8725333222885292 1.0 1.0 4 P27348,P61981,P63104 3 +G protein mediated events 0.3316953316953291 0.1582950533549446 0.8742243058524495 1.0 1.0 6 P08754,P17612,P10644,P28482,P52292 5 +Inlb mediated entry of listeria monocytogenes into host cell 0.3935652318175399 0.1563084833227707 0.8757898698071633 1.0 1.0 4 P62993,P42566 2 +Rhobtb gtpase cycle 0.2562336709659285 0.1537732309298246 0.8777885413827575 1.0 1.0 28 Q9NYL9,Q5VTR2,P38159,Q7Z6E9,P12814,O43396,Q8N684,P61201,P08670 9 +Cell cycle mitotic 0.2503596911997849 0.1525409447200646 0.8787602990589223 1.0 1.0 201 P31350,P30260,Q99460,P28072,P28074,Q9UL46,P28070,O00231,O43237,P14635,Q99436,P41440,P49642,P39748,Q07864,P51665,Q86XL3,P33993,Q8N3U4,Q15691,Q8NFH4,Q9UJX2,P30153,O43633,P63151,O43264,O43683,O60763,Q01105,P27694,P33991,P49721,Q15021,Q9UNM6,Q14974,P06493,P17612,P35998,O75935,P68371,P62191,Q7Z460,P20618,Q8NI77,Q13409,O95684,O43242,Q13547,O14818,P06400,P25205,P15927,P49643,Q92973,Q16763,Q14203,P51530,P48556,Q9Y6G9,Q9UJX4,P25789,P25787,Q9BRT9,Q9Y2U8,Q9BUF5,Q9P258,P11802,Q92530,P00374,Q13200,O43768,P63208,Q9NTJ3,Q9Y266,P09884,Q9UN37,P60900,Q15008,Q06323 79 +Rap1 signalling 0.4836082984238836 0.1523003166233955 0.8789500752042183 1.0 1.0 3 P17612 1 +Aurka activation by tpx2 0.2586739275523161 0.1509786982534979 0.8799925195934146 1.0 1.0 23 Q15691,O95684,Q13409 3 +Uptake and actions of bacterial toxins 0.3284193284193261 0.1508843733848727 0.8800669275854427 1.0 1.0 6 P07900,Q02750,Q8WUM4,P13639,P08238 5 +Recycling pathway of l1 0.2579070650727979 0.1479374704705873 0.882392116387883 1.0 1.0 20 P15311,Q16555,P26038,P35241,Q9BUF5,P50570,Q15418,P53680 8 +Copi mediated anterograde transport 0.242814813293636 0.1456026659405127 0.8842350633002005 1.0 1.0 45 P46459,Q14789,Q01082,Q14204,Q92538,Q14203,Q8N6T3,Q9Y6G9,O60763,Q13813,Q9UJW0,O43237,P35606,P18085,P61163,O75935,Q9BUF5,P68371,P53618,P83436,P61923,Q13409,Q9UBF2,Q9Y678,Q9BVK6,P53621 26 +Apoptotic execution phase 0.255247102130586 0.1444195989021962 0.8851691413561655 1.0 1.0 26 O00273,Q9UDY2 2 +Darpp 32 events 0.2996065990908427 0.1384494025802586 0.8898852553048955 1.0 1.0 8 P10644,P30153,Q00535,P17612 4 +Listeria monocytogenes entry into host cells 0.3189663780229821 0.1305713214752646 0.8961144306085023 1.0 1.0 6 P62993,P42566 2 +Interleukin 17 signaling 0.2672460698769888 0.1297989023928325 0.8967255313326294 1.0 1.0 15 P51452,P61088,P63208,Q02750,Q14738,Q15418,P30153 7 +Runx2 regulates osteoblast differentiation 0.3772504091652985 0.1263106770604363 0.8994860048802396 1.0 1.0 4 P27361,Q13951,P06400 3 +Copi independent golgi to er retrograde traffic 0.2520747159291795 0.1238417944102398 0.9014405393553426 1.0 1.0 22 Q14203,Q9Y6G9,Q13409,Q15042 4 +Recruitment of numa to mitotic centrosomes 0.2482833718292483 0.1178872684678212 0.9061569811917876 1.0 1.0 27 P06493,Q13409,P17612,Q14203,O95684,Q15691,O75935,Q9BUF5,P68371,P30153 10 +Scavenging by class f receptors 0.3702945990180029 0.1146825895733607 0.9086967143743698 1.0 1.0 4 Q92598,P07900,P27797 3 +Ca dependent events 0.3315595579205906 0.1132245027391377 0.909852570199208 1.0 1.0 5 P10644,P28482,P17612,P52292 4 +Rho gtpases activate nadph oxidases 0.3283620157434607 0.1076291871880071 0.9142898434437876 1.0 1.0 5 Q13526 1 +Sars cov 1 infection 0.2613222404106093 0.1055414803464137 0.915946157208986 1.0 1.0 11 O43633,Q99570 2 +Nuclear events stimulated by alk signaling in cancer 0.2607406480519789 0.1043864291053931 0.9168626918493948 1.0 1.0 12 P63208,Q86WB0,P40763 3 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.2825131497200211 0.1019053249324819 0.9188318232846552 1.0 1.0 8 P14635,Q99873,Q07812,Q86X55 4 +Interaction between l1 and ankyrins 0.4486707566462258 0.1003703433752065 0.9200503134045082 1.0 1.0 3 Q01082,Q13813 2 +Adora2b mediated anti inflammatory cytokines production 0.3233729021694649 0.0992334004641509 0.920952955992127 1.0 1.0 5 P10644,P08754,P13861,P17612 4 +Phosphorylation of emi1 0.4475122390854619 0.0988910393244934 0.9212247836146435 1.0 1.0 3 P14635 1 +Resolution of abasic sites ap sites 0.2519243483240352 0.0968418867170302 0.9228519594524438 1.0 1.0 17 P27695,P41440,P39748,Q07864,P15927 5 +Irf3 mediated induction of type i ifn 0.3176422431436771 0.090090733788921 0.9282151126420088 1.0 1.0 5 Q9UJV9,P78527,P12956,P13010 4 +Telomere c strand lagging strand synthesis 0.2472354041484851 0.0897225409284894 0.9285077031120632 1.0 1.0 18 P41440,P49642,P51530,P39748,P09884,P15927 6 +Hiv elongation arrest and recovery 0.2530684040569593 0.087322249219825 0.9304153692492554 1.0 1.0 13 Q8WX92,O00267,Q08945,Q9H3P2 4 +Cytosolic iron sulfur cluster assembly 0.2919400304499198 0.0813577542468742 0.9351574449175828 1.0 1.0 6 Q9Y5Y2 1 +Rna polymerase ii transcription 0.2465005492053108 0.081295250455781 0.9352071510771112 1.0 1.0 250 Q92530,Q9C0C2,Q16763,Q9UQ84,Q9UPN9,P51530,P48556,P04179,Q9UJX4,Q9H3P2,Q99873,Q13200,Q12824,Q92547,O00267,P43246,P25789,Q92600,Q06124,P31350,P30260,Q04917,P25787,P49721,Q9H814,Q86X55,Q99460,Q13526,Q8WX92,P28072,P28074,Q9UL46,P28070,Q6PD62,P54619,P30876,Q14353,O15047,O00231,Q99436,P61964,Q9H9B1,P63208,Q13247,P51665,P15927,Q08945,Q9NQ88,Q9NYV4,Q9NVI1,O95983,P20618,Q15008,P11413,Q13451,O43242,Q8WXI9,Q9BXW9,Q8N684,Q9UJX2,P17931,Q00535,Q9ULK4,O14744,P11802,P60900,Q07812,Q13263,Q92804,Q06323,Q96J02 71 +Amino acids regulate mtorc1 0.2702001046254585 0.0793567557709025 0.9367488640135264 1.0 1.0 8 P21281,Q6IAA8 2 +Telomere c strand synthesis initiation 0.3092085250879887 0.0776005791357822 0.9381457816884696 1.0 1.0 5 P49642,P09884,P49643 3 +Rab regulation of trafficking 0.2387587818128839 0.0763508019260156 0.9391400096683926 1.0 1.0 22 Q8TC07,Q15042 2 +Activation of nima kinases nek9 nek6 nek7 0.3428805237315883 0.0755418668139985 0.9397835877789478 1.0 1.0 4 P14635,P06493,Q8TD19 3 +Rhov gtpase cycle 0.2470757419979587 0.0743216544723114 0.9407544469030328 1.0 1.0 12 Q01082,Q03001,Q13813,O43396,Q13177,P60953,Q93008,P46940 8 +Pyroptosis 0.3055802878058625 0.0725763922646779 0.942143213410171 1.0 1.0 5 O43633,Q07812 2 +Polb dependent long patch base excision repair 0.335140637010478 0.0663715026195197 0.9470820577765002 1.0 1.0 4 P27695 1 +Copii mediated vesicle transport 0.2351196186265067 0.0631262928944639 0.9496659373464872 1.0 1.0 23 Q15436 1 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.3314238952536787 0.0622509904436571 0.9503629566931032 1.0 1.0 4 P10644,P46940,P17612 3 +Signal transduction by l1 0.2695616550593979 0.0593869971766852 0.952643869530282 1.0 1.0 7 P27361,P67870,P19784,Q02750,O14786,P28482 6 +Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.2361989740186156 0.0549395347758862 0.9561866352289076 1.0 1.0 16 Q14258,Q07864,P15927,P41440 4 +Establishment of sister chromatid cohesion 0.2731367731367689 0.0547573239339003 0.956331799928908 1.0 1.0 6 Q9UQE7,Q9NTI5,Q8N3U4,Q29RF7,O60216 5 +Cohesin loading onto chromatin 0.2731367731367689 0.0547573239339003 0.956331799928908 1.0 1.0 6 Q9UQE7,Q9NTI5,Q8N3U4,Q29RF7,O60216 5 +Pka activation in glucagon signalling 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Fcgr3a mediated il10 synthesis 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Creb1 phosphorylation through the activation of adenylate cyclase 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Vasopressin regulates renal water homeostasis via aquaporins 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Pka mediated phosphorylation of creb 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Glucagon signaling in metabolic regulation 0.4002877235354208 0.0510292888783102 0.959302181795184 1.0 1.0 3 P10644 1 +Wnt ligand biogenesis and trafficking 0.3983640081799596 0.0495618111317083 0.9604715795129486 1.0 1.0 3 O75436,Q96QK1 2 +Hiv transcription elongation 0.2329019035243606 0.0469726636897169 0.9625350146868809 1.0 1.0 15 Q8WX92,O00267,Q08945,Q9H3P2 4 +Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0.4088307440719637 0.0463676224066513 0.9630172423213188 1.0 1.0 2 P61088 1 +Activation of atr in response to replication stress 0.23219545907369 0.0460039010981785 0.9633071405766932 1.0 1.0 13 P27694,P33993,P33991,P15927 4 +Wnt5a dependent internalization of fzd4 0.2463850970072825 0.0444780641070089 0.9645233369764497 1.0 1.0 8 P09497 1 +Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.2463850970072825 0.0444780641070089 0.9645233369764497 1.0 1.0 8 P09497 1 +Keratinization 0.2816209578387241 0.0444728772190207 0.964527471423164 1.0 1.0 5 Q14574,P15924,P14923,P07384 4 +Formation of the cornified envelope 0.2816209578387241 0.0444728772190207 0.964527471423164 1.0 1.0 5 Q14574,P15924,P14923,P07384 4 +Opioid signalling 0.2264552731157403 0.0404135148446221 0.967763455764164 1.0 1.0 11 P10644,P30153,Q00535,P17612 4 +Role of abl in robo slit signaling 0.3848876181856681 0.04023004190939 0.9679097270306988 1.0 1.0 3 Q01518 1 +Signaling by fgfr in disease 0.2286875819120703 0.0402183421230361 0.9679190545606372 1.0 1.0 13 O95684,P40763 2 +Retrograde neurotrophin signalling 0.241393442622958 0.038558528896996 0.9692423668318196 1.0 1.0 8 O94973,P63010,Q96CW1,P09496,P50570,Q00610,P53680 7 +Syndecan interactions 0.3813459598126525 0.0380418127443041 0.9696543443913744 1.0 1.0 3 Q9Y296 1 +Negative feedback regulation of mapk pathway 0.3770961145194259 0.0355539780121897 0.9716380053251356 1.0 1.0 3 P27361,Q02750 2 +Smad2 smad3 smad4 heterotrimer regulates transcription 0.3770961145194235 0.0355539780121883 0.9716380053251368 1.0 1.0 3 P27361,Q13547 2 +Rna polymerase i transcription termination 0.2271422714227193 0.0352370188325495 0.9718907437897256 1.0 1.0 9 O95602,O15446,Q9H9Y6,P17480,Q3B726,P18074,P19388,Q9GZS1 8 +Trafficking of ampa receptors 0.2412945514133542 0.0268761101608109 0.9785585479631912 1.0 1.0 7 P46459,O94973,P63010,Q96CW1,Q9UM54,P53680 6 +Vldlr internalisation and degradation 0.2412945514133535 0.0268761101608103 0.9785585479631916 1.0 1.0 7 O94973,P63010,Q96CW1,P09496,Q00610,P53680 6 +Trafficking of glur2 containing ampa receptors 0.2411957411957374 0.0227738542641396 0.9818306638892088 1.0 1.0 6 P46459,O94973,P63010,Q96CW1,P53680 5 +Nef mediated cd4 down regulation 0.241195741195737 0.0227738542641393 0.9818306638892088 1.0 1.0 6 O94973,P63010,Q9UI12,Q96CW1,P53680 5 +Nef mediated cd8 down regulation 0.241195741195737 0.0227738542641393 0.9818306638892088 1.0 1.0 6 O94973,P63010,Q9UI12,Q96CW1,P53680 5 +Dna damage bypass 0.2193762599684106 0.0227201665600079 0.9818734893984756 1.0 1.0 18 P41440 1 +Neurexins and neuroligins 0.3432672051482518 0.0205376776670197 0.983614455976214 1.0 1.0 3 Q96HC4 1 +Nuclear signaling by erbb4 0.3378331982876555 0.0188157892141056 0.9849880580814204 1.0 1.0 3 P16949 1 +Signaling by moderate kinase activity braf mutants 0.2086326345375085 0.0175704524026608 0.9859815286042516 1.0 1.0 10 Q02750,P18206,P30086,Q9Y490 4 +Robo receptors bind akap5 0.3311529026982905 0.0166227522045453 0.9867375734306228 1.0 1.0 2 P17612 1 +Rab gefs exchange gtp for gdp on rabs 0.2128625019263519 0.0138592567181059 0.9889422670345956 1.0 1.0 16 P31150,P20339,Q15042,Q9Y296,Q14C86 5 +E2f enabled inhibition of pre replication complex formation 0.2930045877727885 0.0098541945057953 0.9921376175911863 1.0 1.0 3 P14635 1 +Perk regulates gene expression 0.2025757074568981 0.0095268673203595 0.9923987746351656 1.0 1.0 12 Q92945,P05198,Q9Y2L1 3 +Chl1 interactions 0.2691206543967199 0.0077349827235274 0.993828438247595 1.0 1.0 3 P11142,O14786 2 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e8339ca992d15c3e08f03f69208197f48d8cda13 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Chylomicron remodeling", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdl remodeling", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O glycosylation of tsr domain containing proteins", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD6", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APOC3", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BSG", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDKAL1", "CDS2", "CERS1", "CERS2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHTOP", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLCN7", "CLINT1", "CLNS1A", "CLSPN", "CLTA", "CLTB", "CLTC", "CMAS", "CMBL", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT9", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPM1", "DPYSL2", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFTUD2", "EHD1", "EHMT1", "EHMT2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERI1", "ERLIN2", "ERO1A", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF2", "FAHD1", "FAM114A2", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP4", "FKBP5", "FKBP8", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNTA", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLS", "GLUD1", "GMPS", "GNA13", "GNAI3", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GUSB", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRPPRC", "LRRC1", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYPLA1", "LYPLA2", "M6PR", "MAGED2", "MAIP1", "MAN2B1", "MANF", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MARC1", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME2", "MECP2", "MED1", "MED23", "METAP2", "MFN1", "MGA", "MGST2", "MGST3", "MIA3", "MIF", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYDGF", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA35", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFA", "NELFB", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIP7", "NISCH", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD11", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF5A", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIN1", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PNO1", "PNP", "POFUT1", "POFUT2", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPIB", "PPID", "PPIE", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PTBP1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUS1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RARS", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", 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0000000000000000000000000000000000000000..409483379925050e625ff2546bcb1c2f162ab2d8 --- /dev/null +++ b/msigdb_wp/df_merge.tsv @@ -0,0 +1,13 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Vegfavegfr2 signaling pathway 51 153 3.0515889640739964 0.0022763358072621 49.310679611650485 172.9902912621359 -0.5768340549469878 0.5576026347888529 17.103783222112053 11.649613640521252 1.0023132128227763 0.3475484700489779 1.0 0.0034575190363444 0.0174411567838328 0.0007445248700006 1.835204448538113e-05 +Translation factors 15 36 2.927789990619869 0.0034138054418539 11.012135922330096 36.407766990291265 0.237804702796095 0.5855996076835563 7.095899834901985 1.2400038615965827 1.0529950625688889 0.3465203977253575 1.0 0.1321770275182459 0.0507921856702582 0.0201532937471319 1.6584825840013934e-07 +Proteasome degradation 17 41 2.650832804599124 0.0080293578232124 12.050970873786408 41.16504854368932 0.6913339882315582 0.5158259179783452 5.889337413827548 1.124286935861288 1.1356581007954978 0.3607938079641982 1.0 1.0 0.000574180538616 0.0001081741563921 2.568859600709239e-06 +Wnt signaling pathway 1 7 2.320445385807307 0.0203167961025834 3.9563106796116503 12.050970873786408 -0.1668721405390101 0.6077108119526166 2.6112218582109348 2.3264673893512393 0.8231911322186768 0.2957072479206077 1.0 0.1218413011779254 0.0434222212102392 0.2485650807277314 0.6109936921014887 +Fas ligand pathway and stress induction of heat shock proteins 2 12 2.307946518406069 0.021002111287812 5.053398058252427 14.822815533980584 -0.4554743114979069 0.5253434329066327 2.5660333762738876 2.3627702670603266 0.8576942488227776 0.3061103839111958 1.0 0.1087542187866123 0.2563609064437679 0.5769052494947983 0.2693961077242547 +Cytosine methylation 1 5 2.29783697487683 0.0215710694682478 2.0533980582524274 4.839805825242719 -0.0649747594084269 0.3077365108683944 1.3517565367896365 0.4045469252427314 1.4549970578233429 0.2999126289601936 1.0 0.0002974646885289 0.0019582426196627 0.0153606094450382 0.0067175441106752 +Wnt signaling pathway and pluripotency 2 12 2.186446433091026 0.0287829596577515 5.058252427184466 15.563106796116504 -0.2536415632085242 0.5941084533998887 3.611807074588496 2.6224197782675756 0.8366764417562451 0.2997964441235839 1.0 0.1965488752384769 0.0182961528204827 0.2180247724103086 0.6726087198574483 +Glutathione metabolism 3 6 2.1455342958030044 0.0319101523768701 2.3519417475728157 6.143203883495145 -0.0475883211244437 0.4626181588106582 1.726414185053583 0.9302768286101702 1.0838595673401377 0.3130544273100991 1.0 0.0290494193324047 0.0730355121895775 0.0189279309569866 0.0007618049132778 +Metapathway biotransformation phase i and ii 2 19 2.108874486912236 0.0349554169460959 5.674757281553398 21.74757281553398 1.0367643596879972 0.3247805075973627 2.26648088910968 1.8784337960788755 0.9302956939670612 0.2816826074355951 1.0 0.1624835239406421 0.3662905234510716 0.1420865307168483 0.5301357026562379 +Wnt signaling 1 8 2.091925094542513 0.0364452168656566 4.325242718446602 13.79611650485437 -0.144557810634112 0.6275043151948031 2.980689255228292 2.7122849726447233 0.7658223182118875 0.2969195277776951 1.0 0.2013046550150269 0.1123469419649493 0.4956145616542792 0.8731307295920969 +Oxysterols derived from cholesterol 0 7 2.033861005806477 0.0419656115172579 2.254854368932039 7.33252427184466 0.1962044165430426 0.4767358733288924 1.826344624524478 1.1378784708655931 1.058988657917013 0.30869858242651 1.0 0.0488968448915506 0.1210018791987308 0.3123886245550609 0.5535471472564869 +Intracellular trafficking proteins involved in cmt neuropathy 1 5 2.014074096568379 0.0440017546650923 2.5825242718446604 9.4126213592233 0.5651067696606721 0.3956590939588119 1.7010805922853014 1.920668351091252 1.0307289556591432 0.2847016918534578 1.0 0.0628328620388111 0.0117927249980906 0.0820001849767809 0.0790760036833716 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..02d112d94ba74da6968a1dc3bf08d99884015041 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 586, + "title": "Average number of proteins per term", + "value": 8.764505119453926 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..292e9921b1c4626eb863deca942f2f3205f1bec0 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c9c190978ff24b9c0de74345957ae5fb9b2f6170 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,214 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vegfavegfr2 signaling pathway 0.4294737370652592 3.0515889640739964 0.0022763358072621 0.7369610951322889 0.2097223203837764 153 Q9NYL9,P48735,P04792,Q96PU8,P00338,P78344,P04083,P04179,P61586,Q04637,Q15075,O15460,Q01105,P35579,Q06124,P31948,P42566,Q9NZB2,P62993,O60568,P53680,O00231,P06730,P05387,P15311,P18085,P31689,P51116,P49257,Q6ZRI6,Q7Z478,P35613,Q8WU90,P05198,P60953,Q6Y7W6,O15372,Q96B36,Q9Y520,P20339,Q96CT7,O15355,Q13177,P04406,P18206,Q01844,P40763,P46777,P17655,Q14157,Q96J02 51 +Translation factors 0.6027643864602907 2.927789990619869 0.0034138054418539 0.8651931710560224 0.2097223203837764 36 O75153,P60228,P29692,P55884,P60842,P56537,Q9UI10,Q9NR50,P23588,O75822,P05198,P24534,Q04637,P55010,P06730 15 +Proteasome degradation 0.532362534906445 2.6508328045991236 0.0080293578232124 0.9911221449094872 0.2105374079771204 41 Q99436,Q15008,P25787,P49721,P48556,O43242,Q99460,P51665,P28072,P28074,P60900,Q13200,Q9UL46,P28070,P20618,P25789,Q06323 17 +Wnt signaling pathway 0.8441288238435083 2.320445385807307 0.0203167961025834 0.9999940269223936 0.2768754073514856 7 P61586 1 +Fas ligand pathway and stress induction of heat shock proteins 0.7158232803824333 2.307946518406069 0.021002111287812 0.9999960362290096 0.2797099366967694 12 O00273,P04792 2 +Cytosine methylation 0.91133050192461 2.29783697487683 0.0215710694682478 0.9999971805697434 0.2809032601865161 5 P48735 1 +Wnt signaling pathway and pluripotency 0.6914945070037739 2.186446433091026 0.0287829596577515 0.9999999630726556 0.3526308921450782 12 Q13363,P61586 2 +Glutathione metabolism 0.8281278517740036 2.1455342958030044 0.0319101523768701 0.9999999944206952 0.3641538427224786 6 P28161,P11413,O75874 3 +Metapathway biotransformation phase i and ii 0.5904693610060162 2.108874486912236 0.0349554169460959 0.9999999991194316 0.3793310061187449 19 P34913,Q86UY6 2 +Wnt signaling 0.7569767439782804 2.091925094542513 0.0364452168656566 0.9999999996438956 0.3835084128357227 8 P61586 1 +Intracellular trafficking proteins involved in cmt neuropathy 0.8396937198837404 2.014074096568379 0.0440017546650923 0.9999999999964694 0.4046905359437045 5 P04792 1 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.6355982520288999 1.949424082077044 0.0512448009171837 0.999999999999959 0.4467569367923216 13 P60228,P55884,P56537,O75822,P05198,P55010 6 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.6415756673594002 1.9320030670983 0.0533591273158684 0.9999999999999888 0.4531659218420132 12 Q96AY3,Q5JRA6 2 +Pdgf pathway 0.6665998834432673 1.9134490325504832 0.0556905923960002 0.9999999999999972 0.4662098163436594 10 P61586,P40763,Q06124 3 +Male infertility 0.5660107725133795 1.875073920365736 0.0607825548219098 1.0 0.4929922241333861 18 P17096,P41440,Q99707,P34896,P04179 5 +Spinal cord injury 0.601038215432458 1.8702719645998516 0.0614460606557927 1.0 0.4929922241333861 15 P61586,P04083 2 +Acute viral myocarditis 0.6153346854828028 1.7955982487992932 0.0725584346082 1.0 0.5061814604810143 12 O00273,P40763,Q07812,Q04637 4 +Cellular proteostasis 0.8424713584288027 1.7538337912704671 0.0794589910972649 1.0 0.5352065377356008 4 P61758,O15212,Q99471 3 +1q211 copy number variation syndrome 0.7000663540813951 1.701785522507216 0.0887955814137813 1.0 0.5781578967608426 7 Q9UDY2,Q9NPH0,Q9Y624 3 +Ras signaling 0.5568984323633323 1.676736280267612 0.0935940627850766 1.0 0.6027046240885156 16 P20339,P62993,P0DP25,P60953,Q9UQ13,P61586,P11233,Q06124 8 +Alpha 6 beta 4 signaling pathway 0.6554923084078935 1.630767813630826 0.1029393213505023 1.0 0.6402582653439286 8 P61586,P11047,Q06124 3 +Adipogenesis 0.5668154798160254 1.6267220891121954 0.1037961351666778 1.0 0.6402582653439286 14 P43490,P14174,P17096 3 +Mbdnf and probdnf regulation of gaba neurotransmission 0.6981187494467502 1.596356961163706 0.1104091193822238 1.0 0.6521663552335992 6 P61586 1 +Ras and bradykinin pathways in covid19 0.7987137838878249 1.581422246998117 0.1137815240519373 1.0 0.6521663552335992 4 P61586 1 +Microtubule cytoskeleton regulation 0.5662042810211244 1.5772973963936427 0.1147271112088264 1.0 0.6521663552335992 13 P06493,P17612,Q9Y281,Q16555,P16949,Q15691,P40763,P60953 8 +Autophagy 0.7282413904931764 1.556700361441833 0.1195416428141289 1.0 0.6521663552335992 5 Q9NT62,Q96B36,Q99570 3 +Dna mismatch repair 0.5532916669782233 1.5514517779428314 0.1207934550461145 1.0 0.6521663552335992 14 Q9UQ84,P15927,P41440 3 +G protein signaling pathways 0.6376145225212448 1.5476062973097902 0.121717114334019 1.0 0.6521663552335992 8 P61586 1 +Vitamin dsensitive calcium signaling in depression 0.6834463590351466 1.532745121353992 0.1253386669667513 1.0 0.6521663552335992 6 P11413,Q8NB78 2 +Cell migration and invasion through p75ntr 0.9010629599345896 1.5310418851304788 0.1257590411969227 1.0 0.6521663552335992 2 P61586 1 +Methionine metabolism leading to sulfur amino acids and related disorders 0.7840312549389673 1.5231716206208357 0.1277157741848116 1.0 0.6545040648035857 4 P55263 1 +Atm signaling in development and disease 0.4737723783384034 1.4954574025251768 0.1347951091278023 1.0 0.6655438543725335 22 P04792 1 +Il6 signaling pathway 0.5935333660212717 1.4676092847173294 0.1422103845149918 1.0 0.6655438543725335 9 P40763,Q06124 2 +Integrinmediated cell adhesion 0.5433451128021671 1.4524386485418177 0.1463796765125882 1.0 0.6655438543725335 13 P62993,Q15942,P07384,Q13177,P60953,Q9Y490,P17655 7 +Pilocytic astrocytoma 0.8793949304987733 1.443175519376654 0.1489710338436893 1.0 0.6655438543725335 2 Q06124 1 +Embryonic stem cell pluripotency pathways 0.6119278427350041 1.4273638975144007 0.1534750314152515 1.0 0.6655438543725335 8 P40763,Q06124 2 +Cysteine and methionine catabolism 0.6583461746613786 1.4233711294127949 0.1546285971781191 1.0 0.6655438543725335 6 Q99707,P48506 2 +Methionine de novo and salvage pathway 0.656494882827655 1.4152806681584755 0.1569862207614329 1.0 0.6655438543725335 6 Q99707 1 +Dna irdamage and cellular response via atr 0.4271895567085408 1.4144634635803706 0.1572258676779603 1.0 0.6655438543725335 32 Q9UQ84,P39748,Q92900,Q9BXW9,P46063,Q13263,Q9NVI1,Q92547,P43246,O43324,P15927 11 +Complement system 0.582575035045255 1.413925182020783 0.1573838712493225 1.0 0.6655438543725335 9 Q99829,P17612,P11047,P26885,P39019 5 +Histone modifications 0.608717311368881 1.412282671051177 0.157866746738847 1.0 0.6655438543725335 8 Q9H7B4,O15047,Q01105 3 +Nanomaterial induced apoptosis 0.756183366746076 1.4122787159068129 0.1578679108494576 1.0 0.6655438543725335 4 O95831,Q9NR28 2 +Neural crest cell migration during development 0.745908346972165 1.3712623659466971 0.1702931829181111 1.0 0.6802203424425697 4 P61586,P40763,Q99570 3 +Initiation of transcription and translation elongation at the hiv1 ltr 0.6789904370931819 1.349972889947424 0.1770246790348086 1.0 0.6802203424425697 5 Q8WX92,Q9H3P2 2 +Pdgfrbeta pathway 0.640784419812665 1.3465210857843757 0.1781345248754378 1.0 0.6802203424425697 6 P40763 1 +Insulin signaling 0.428899472350546 1.3445797779910014 0.1787609773654535 1.0 0.6802203424425697 28 O60343,Q01518,P62993,P41440,Q9H4M9,P06730,Q99570,P17858,Q15418,P13807,P33176,Q06124 12 +Pancreatic adenocarcinoma pathway 0.5067770878657559 1.3339346788973727 0.1822252650590874 1.0 0.6889290666104854 15 Q13177,P40763,P06400,Q07812,P60953,P11802,P61586,P11233,P30086 9 +Interleukin11 signaling pathway 0.5466260061146637 1.3129246474799416 0.1892083406004547 1.0 0.6981163346272403 10 P40763,Q06124,Q15257 3 +Target of rapamycin tor signaling 0.6700524935097739 1.312294925440336 0.189420643695787 1.0 0.6981163346272403 5 Q96B36,P54619 2 +Pyrimidine metabolism 0.3984294463942923 1.2872419245781177 0.1980099786452691 1.0 0.7073817779733347 36 Q9H773,O95602,P30085,P31350,Q9BZX2,P49642,Q05682,Q9NRF8,P11172,P09884,P30876,P17812 12 +Epo receptor signaling 0.6199279066339622 1.255037693530668 0.2094650768729704 1.0 0.7192622667750737 6 P40763 1 +Il9 signaling pathway 0.6199279066339622 1.255037693530668 0.2094650768729704 1.0 0.7192622667750737 6 P40763 1 +Extracellular vesicles in the crosstalk of cardiac cells 0.8401777291926082 1.254941611050674 0.2094999569610096 1.0 0.7192622667750737 3 P04792 1 +Dna repair pathways full network 0.3941091152646397 1.25050666541813 0.2111145219885881 1.0 0.7192622667750737 36 P27695,P41440,Q9UQ84,Q9BXW9,P54727,P43246,P15927 7 +Nuclear receptors metapathway 0.373478731633559 1.2418418779590177 0.2142949081175209 1.0 0.7258775500396952 41 P02656,P11413,Q13451,P48506,P40763,P25685,Q15257,P11802,P28161 9 +Glycogen synthesis and degradation 0.4888466724614137 1.2303534828824745 0.2185647645953017 1.0 0.7297339316994796 15 P06737,P0DP25,Q15257,P13807,P30153,P36871 6 +Apoptosis 0.5948052232182255 1.2290924755110073 0.2190371360045662 1.0 0.7297339316994796 7 O00273,Q99590,Q9NR28 3 +Regulation of actin cytoskeleton 0.4192018256971525 1.1657497578954068 0.2437156360294081 1.0 0.7559773370422795 24 P15311,Q9UQB8,Q9Y281,Q02750,P26038,P35241,P12814,Q99570,P35580,Q13177,Q9Y2A7,P18206,P60953,P61586,P41240 15 +Physicochemical features and toxicityassociated pathways 0.5155034591181735 1.1543340815500047 0.2483632289100008 1.0 0.7559773370422795 10 P62993,P61586 2 +Tnfalpha signaling pathway 0.473587434599245 1.1031243052215347 0.2699731872042947 1.0 0.7559773370422795 14 P63208,P62993,Q9NR28,Q07812,Q13200 5 +Onecarbon metabolism and related pathways 0.504222315320074 1.0969015437783272 0.2726844338320178 1.0 0.7559773370422795 10 P34896,P04179 2 +Chromosomal and microsatellite instability in colorectal cancer 0.483676742710384 1.0921115439388058 0.2747840759857736 1.0 0.7559773370422795 12 P61586,P43246,Q07812,P11233 4 +Acquired partial lipodystrophy barraquersimons syndrome 0.6171969716460608 1.0894659470026424 0.2759484637023475 1.0 0.7559773370422795 5 Q03252 1 +Physiological and pathological hypertrophy of the heart 0.6155109370200477 1.0823783887509824 0.2790844271073309 1.0 0.7559773370422795 5 P61586 1 +Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence 0.4823728821308208 1.057223229729337 0.2904097204795768 1.0 0.7559773370422795 11 P43490 1 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.4588381637685064 1.0571423422566342 0.2904466292752881 1.0 0.7559773370422795 15 P04792 1 +Hepatitis b infection 0.4236530909926596 1.047703119895644 0.2947754096950565 1.0 0.7559773370422795 19 Q15904,P40763 2 +Micrornas in cardiomyocyte hypertrophy 0.4692343865656226 1.0445690271543842 0.2962222008091335 1.0 0.7559773370422795 13 P61586 1 +Folate metabolism 0.4742127425032513 1.0412462751478413 0.2977612639180571 1.0 0.7559773370422795 12 P34896,P04179,P41440 3 +Influence of laminopathies on wnt signaling 0.4928147832660651 1.0389507991338018 0.2988276190528678 1.0 0.7559773370422795 10 Q9UPY3 1 +Apoptosis modulation and signaling 0.5053973570470467 1.034242435504814 0.3010228403616692 1.0 0.7559773370422795 9 O95831,O00273,Q9NR28 3 +Il3 signaling pathway 0.4888243796278649 1.0187224508664474 0.3083347509629119 1.0 0.7572304224028086 10 P40763,Q06124 2 +Nitric oxide metabolism in cystic fibrosis 0.598954828959087 1.0129411543442035 0.311088269427459 1.0 0.7572304224028086 5 O60678,Q99873,O14744 3 +Vasopressinregulated water reabsorption 0.4618633235795656 1.0041695404808764 0.3152969010660529 1.0 0.7572304224028086 13 Q13409,P20339,Q14203,P52565,Q9Y6G9,Q9UJW0 6 +Striated muscle contraction pathway 0.6497699079081318 0.988243382053408 0.3230334665409931 1.0 0.7572304224028086 4 P35609 1 +Kallmann syndrome 0.7565180949421957 0.9463314499873235 0.3439795571443174 1.0 0.7903168602930943 3 Q06124 1 +Rala downstream regulated genes 0.755828220858885 0.943827358618781 0.3452578775341846 1.0 0.7903168602930943 3 P11233,P16989 2 +Transsulfuration pathway 0.545412535301284 0.929276564344798 0.3527457773253541 1.0 0.8011977733048742 6 Q99707 1 +Intraflagellar transport proteins binding to dynein 0.5438184404937371 0.9223842417292332 0.3563281864887664 1.0 0.8035859288260905 6 Q13409,Q9BW83 2 +Netrinunc5b signaling pathway 0.4565374041117526 0.9219628988359176 0.356547928366612 1.0 0.8035859288260905 11 P61586 1 +G13 signaling pathway 0.4513979190725974 0.91935266603941 0.3579111389481393 1.0 0.8035859288260905 12 P61586 1 +Ethanol effects on histone modifications 0.4678889597325566 0.9131369384424765 0.3611705251935968 1.0 0.8050021822327142 10 Q99707,P41440 2 +Focal adhesion 0.3753011842478811 0.8996592321816463 0.368301625081745 1.0 0.8058366561602184 26 P62993,Q15942,P11047,Q9Y490,P61586 5 +Regulatory circuits of the stat3 signaling pathway 0.4985111541921049 0.894268252812612 0.3711783817494969 1.0 0.8058366561602184 8 Q96B36,P40763,P16949 3 +Il4 signaling pathway 0.4982728850581813 0.8931644092042953 0.3717691346078968 1.0 0.8058366561602184 8 P40763,Q06124 2 +Orexin receptor pathway 0.4411692112096187 0.8914923854576275 0.3726650747771658 1.0 0.8058366561602184 13 P55145,P20290,P17096,P00338 4 +Cancer immunotherapy by pd1 blockade 0.7397042692742053 0.8855954813957782 0.3758355473693093 1.0 0.8092504760829686 3 P40763 1 +Pathogenic escherichia coli infection 0.3857934170668805 0.8748478105369479 0.3816567190267772 1.0 0.8103291208322154 21 P15311,P60953,Q14247,O15143,O15144,Q9BUF5,P68371,P59998,P61586,Q92747 10 +Leptin signaling pathway 0.3763205197020313 0.8431361964133675 0.3991522770608238 1.0 0.8323958518065578 23 Q06124,Q9Y281,P62993,P40763,Q07812,P60953,Q15418,P61586,Q07666,P06730 10 +Serine metabolism 0.5219166006736253 0.8283392306404977 0.407478411352886 1.0 0.837868652097221 6 P34896 1 +Progeriaassociated lipodystrophy 0.4508509507101519 0.8281679780473733 0.4075753759806506 1.0 0.837868652097221 10 P46063,Q03252 2 +Atr signaling 0.7244480784955092 0.8258390775059554 0.4088953835144759 1.0 0.837868652097221 2 Q92547 1 +16p112 distal deletion syndrome 0.549345148676149 0.8078546232206025 0.4191742758857959 1.0 0.837868652097221 5 P20339,P62993,Q99873 3 +Tcell antigen receptor tcr pathway during staphylococcus aureus infection 0.498048165067939 0.7953782187747708 0.4263935261222835 1.0 0.837868652097221 7 P62993 1 +Dna damage response only atm dependent 0.4232697757318679 0.7953484755987729 0.4264108226703484 1.0 0.837868652097221 13 P62993,P04179,Q99570,Q07812,P60953,P61586 6 +G1 to s cell cycle control 0.3915800790141979 0.7921562871671566 0.4282695532656857 1.0 0.837868652097221 18 P14635,P27694,P06493,P11802,P33991,P49642,Q07864,P06400,P33993,P25205,P15927 11 +Sarscov2 innate immunity evasion and cellspecific immune response 0.4553195749002511 0.7918037311172202 0.4284751264491613 1.0 0.837868652097221 9 O43747,Q14258,P35613 3 +Neural crest cell migration in cancer 0.5449830193207945 0.7901432494010817 0.4294441143280245 1.0 0.837868652097221 5 P61586,P40763,Q99570 3 +Sulfation biotransformation reaction 0.7127940152499332 0.7899042616134491 0.429583682383083 1.0 0.837868652097221 3 P11413 1 +Melanoma 0.4419168335580375 0.7840895039892185 0.4329875937359191 1.0 0.837868652097221 10 P62993,P18206,P0DP25,Q07812,P06400,P11802 6 +Thermogenesis 0.3638121957715383 0.7751243237604815 0.4382661998759014 1.0 0.8414007475160935 24 O43772 1 +Hostpathogen interaction of human coronaviruses autophagy 0.7055855416211432 0.7646515059350839 0.4444790901321189 1.0 0.842927983227902 3 Q9NT62 1 +Nonsmall cell lung cancer 0.4361964318043679 0.7560750864822646 0.4496041781370863 1.0 0.8471641427277574 10 P62993,Q9HC35,P40763,Q07812,P06400,P11802 6 +Network map of sarscov2 signaling pathway 0.377142720406981 0.7518711023561003 0.4521285778402664 1.0 0.8479033504242509 19 Q96B36,P31350,Q99829,Q6PKG0,Q96AX1,Q96J02,P06730 7 +Transsulfuration and onecarbon metabolism 0.3961100271155395 0.7340064738082999 0.4629447925159011 1.0 0.8518076827745645 16 Q99707,P48506,P34896 3 +Ebola virus infection in host 0.3409693663322948 0.7291062287957858 0.4659366847490918 1.0 0.8532465539467743 32 P42566,P09497,P41440,Q99816,P20339,P05198,Q96AX1,P61586 8 +Egfegfr signaling pathway 0.3440250752381522 0.7148693007273809 0.4746898081360817 1.0 0.866567687126928 29 P42566,P62993,P20339,P16949,P40763,Q15418,P53680,P11233,Q96J02,Q06124 10 +Prostaglandin and leukotriene metabolism in senescence 0.691332788225681 0.7018016710817867 0.4828028564997382 1.0 0.8680423241983185 2 P09960 1 +Rac1pak1p38mmp2 pathway 0.4078895411929912 0.6925574640505148 0.4885873119861124 1.0 0.8680423241983185 12 P62993,P16949,P40763,P43246,Q06124 5 +Il5 signaling pathway 0.4223396071203633 0.6890065153020738 0.4908191675142928 1.0 0.8680423241983185 10 P62993,P40763,Q06124 3 +Steroid biosynthesis 0.6782076673118524 0.6705330376083126 0.5025180531124085 1.0 0.8742630320658981 3 P56937 1 +Hif1a and pparg regulation of glycolysis 0.6723926380368018 0.6509555077276168 0.5150752081618915 1.0 0.8825557660317789 3 P04406,P00338 2 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.3769423904286281 0.627376674527182 0.5304123538888568 1.0 0.8913707229880542 16 Q9UPY3,P49354,Q9Y2U8 3 +Gastrin signaling pathway 0.3565656480909467 0.6259495045129646 0.531348062423451 1.0 0.8913707229880542 19 P61586,P40763,Q06124 3 +Il2 signaling pathway 0.418296733243108 0.6196929595992609 0.5354599517271981 1.0 0.8913707229880542 9 P40763,Q06124 2 +Agerage pathway 0.3847142276468889 0.6166174067845109 0.5374871104137853 1.0 0.8913707229880542 14 P61586,P17931,P40763 3 +Cohesin complex cornelia de lange syndrome 0.391855129076602 0.6121236612201295 0.5404559438773144 1.0 0.8913707229880542 12 P06493,Q8N3U4,Q29RF7,Q14738,Q15257,P30153 6 +Glucuronidation 0.4995316390299747 0.6105231397078107 0.5415153197674869 1.0 0.8913707229880542 5 O95394,P36871 2 +Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells 0.4641419938727227 0.5894329412212986 0.5555708842645783 1.0 0.9049986982327826 6 P20339 1 +Androgen receptor signaling pathway 0.3379543553969274 0.5754864821892697 0.5649623302915279 1.0 0.912032852757122 22 P61586,Q02790 2 +Hepatocyte growth factor receptor signaling 0.4051891616583714 0.5611524578420646 0.5746936096895103 1.0 0.9212007670562758 9 P40763,Q06124 2 +Mecp2 and associated rett syndrome 0.3616898943469847 0.5453317895191628 0.5855253440653618 1.0 0.9276902361707684 16 Q14353,Q13451,P35637 3 +Myometrial relaxation and contraction pathways 0.370691824603849 0.5450153187914469 0.585742981882567 1.0 0.9276902361707684 14 Q04917,P17612,P10644,Q05682,Q99439,P0DP25,P63104 7 +Clear cell renal cell carcinoma pathways 0.315655340817391 0.539129376845458 0.5897975865880025 1.0 0.9279383557599682 32 Q96B36,Q96G03,P34896,P00338,P04406,P40763,P36871 7 +Bdnftrkb signaling 0.4768085186708444 0.5252136188168471 0.5994346986140269 1.0 0.9282799929968282 5 P62993,Q15418 2 +Interferon type i signaling pathways 0.3704594434298202 0.5087610083557709 0.6109197532957666 1.0 0.9371700927521446 12 P23588,P40763,Q99873 3 +Mirna regulation of dna damage response 0.3273095662167029 0.5010111959076844 0.6163632435040338 1.0 0.94190272810791 21 P14635,P41440,Q9BXW9,Q07812,Q00535,P11802,P15927 7 +Photodynamic therapyinduced unfolded protein response 0.3895678203933049 0.4935422589457149 0.6216294880956716 1.0 0.94319758815599 9 O43776,Q13217,P05198,P08243,P23381 5 +Met in type 1 papillary renal cell carcinoma 0.3635874889614851 0.491749131912503 0.6228967007105259 1.0 0.94319758815599 13 Q92733,P62993,P40763,P60953,Q06124 5 +Ciliopathies 0.3664970497870372 0.4774132645258052 0.6330678705504031 1.0 0.9536703654049776 11 Q9UBB4,Q9BW83,Q15555,Q99570 4 +Small cell lung cancer 0.4186298320180164 0.4661848082840458 0.6410832224484417 1.0 0.9555053987910126 7 P63208,P11047,P11802 3 +Glycosylation and related congenital defects 0.4589606889656468 0.4610104509328706 0.6447911070974583 1.0 0.9555053987910126 5 O75340 1 +Envelope proteins and their potential roles in edmd physiopathology 0.3478460455482078 0.4520826560646666 0.651209437807672 1.0 0.9555053987910126 15 P62993,P61586 2 +Onecarbon metabolism 0.3544074205680508 0.4486073618485289 0.6537149221713068 1.0 0.9555053987910126 13 P34896 1 +Retinoblastoma gene in cancer 0.2895405651101397 0.4477326814119362 0.6543461324426127 1.0 0.9555053987910126 39 P00374,P16949,P09429,P31350,P27694,P33991,Q9NQW6,P14635,P06493,P52701,P23921,P49642,Q07864,Q16204,P33993,P09884,Q13547,P06400,P11802,P15927 20 +Aryl hydrocarbon receptor pathway wp2873 0.4549625008669987 0.4470145987150443 0.65486451929479 1.0 0.9555053987910126 5 P07900,Q07812,Q15185 3 +Il18 signaling pathway 0.2835623131480571 0.44175865077227 0.6586638630821615 1.0 0.9555053987910126 43 P04792,P51858,P35613,Q8N6T3,O60568,Q9UMR5,Q7L2J0 7 +Dna damage response 0.3180445171928413 0.440726146338594 0.6594112655383719 1.0 0.9555053987910126 20 P41440,Q9BXW9,Q07812,Q00535,P11802,P15927 6 +Genes controlling nephrogenesis 0.4172290389432563 0.4122417542732459 0.6801622357027766 1.0 0.9567443577525524 6 P11047 1 +Purine metabolism 0.4041168115701016 0.4116994688142892 0.6805597143776865 1.0 0.9567443577525524 7 P30520,P07741,P00491 3 +Genes related to primary cilium development based on crispr 0.4445641659224835 0.4113400539765999 0.6808232033836423 1.0 0.9567443577525524 5 Q9BW83 1 +Ectoderm differentiation 0.3318775805684794 0.3947758455548646 0.6930083225330006 1.0 0.9634196948632852 16 Q13363,P35237 2 +Neurodegeneration with brain iron accumulation nbia subtypes pathway 0.3819175039570376 0.3929293118439478 0.6943716914918758 1.0 0.9634196948632852 8 Q96B36 1 +Amyotrophic lateral sclerosis als 0.3985634204415647 0.3914863638767794 0.6954377660873201 1.0 0.9634196948632852 7 P20339,P07197,Q9BUN8 3 +Parkinubiquitin proteasomal system pathway 0.2896974977022031 0.3670871123511475 0.7135540401285583 1.0 0.9715228085847868 33 Q15008,P35998,P48556,O43242,Q99460,P51665,Q9BUF5,Q13200,P68371,P68036,P54652,Q9UNM6,O00231 13 +Vitamin b12 metabolism 0.4036736278984379 0.3651696336451682 0.7149847842463741 1.0 0.9715228085847868 6 P04179 1 +Pentose phosphate metabolism 0.4297994269340985 0.3626287856895862 0.7168822040452842 1.0 0.9715228085847868 5 P37837,P52209,P11413,O95336 4 +Nucleotide excision repair 0.3261352876382829 0.350473767410538 0.7259831738441291 1.0 0.9715228085847868 15 P15927,P41440 2 +Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement 0.4251969070943123 0.3479458660099688 0.7278808387588778 1.0 0.9715228085847868 5 P18206 1 +4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression 0.3971839687956278 0.3434206179575861 0.7312820507566415 1.0 0.9715228085847868 6 Q96KB5,P06730 2 +Cell cycle 0.2757081402549862 0.34321845296767 0.7314341234481165 1.0 0.9715228085847868 39 P14635,P30260,P06493,Q04917,P33991,P63208,Q8N3U4,P11802,Q13547,Q9UJX4,P06400,P33993,P63104,Q9UJX2,P25205,O43683,O43684 17 +Alzheimers disease 0.2524512027733792 0.3386024226863258 0.734909257271751 1.0 0.9715228085847868 74 P48556,Q99570,Q13200,P25789,P33176,P25787,P49721,P28072,P28074,P28070,Q99436,P07384,P51665,Q9BUF5,P05198,P20618,Q15008,O43242,P04406,P60900,P0DP25,Q00535,P17655 23 +Glucocorticoid receptor pathway 0.4664484451718443 0.3345648321292848 0.7379533773697169 1.0 0.9715228085847868 4 Q13616,P07900,Q15185 3 +Angiopoietinlike protein 8 regulatory pathway 0.297106232805319 0.3267815053781138 0.7438331487290897 1.0 0.9715228085847868 20 Q01518,P41440,P13807,Q99570,Q15418,P54619 6 +Alzheimers disease and mirna effects 0.250774993195653 0.3207689852280803 0.7483854645769961 1.0 0.9715228085847868 75 P48556,Q99570,Q13200,P25789,P33176,P25787,P49721,P28072,P28074,P28070,Q99436,P07384,P51665,Q9BUF5,P05198,P20618,Q15008,O43242,P04406,P60900,P0DP25,Q00535,P17655 23 +Aryl hydrocarbon receptor pathway wp2586 0.377714051618181 0.3191195202166919 0.749635881936245 1.0 0.9715228085847868 7 P07900,Q02750,Q16543,O00170,P48506,P06400 6 +Malignant pleural mesothelioma 0.2671363048303319 0.3172899471766399 0.751023604588581 1.0 0.9715228085847868 47 Q13363,Q96B36,P61964,P62993,P11047,Q96T88,P23588,Q07812,P11802,Q04637 10 +Chemokine signaling pathway 0.3250298792500111 0.3106625082651446 0.7560572019192171 1.0 0.9733318080273898 12 Q02750,P62993,P40763,P60953 4 +Dna replication 0.291794319127016 0.3022455910243218 0.7624648517859476 1.0 0.9776901600581298 21 P27694,P33991,P41440,P49642,Q07864,P33993,P25205,P09884,P15927 9 +Purine metabolism and related disorders 0.3201970443349685 0.2917743588689959 0.7704591512563639 1.0 0.982812899120062 12 P22102,P30520,P07741,P00492,P31153,P00491,P22234,Q06203,O15067,Q9BY32,P30566 11 +Dopamine metabolism 0.5556009811937951 0.2733648596889144 0.7845727622836609 1.0 0.9844960143430947 2 P17612 1 +Brainderived neurotrophic factor bdnf signaling pathway 0.2693430262717264 0.2523407630953896 0.8007776829225031 1.0 0.9910219659598026 35 P29966,Q06124,Q96S59,P62993,Q15418,P67809,P40763,O00763,P05198,P60953,Q00535,P06730 12 +Measles virus infection 0.2905176557564477 0.2471199047552572 0.8048154296028147 1.0 0.9910219659598026 18 P11802,P40763,Q07812,P05198,P54652,O15372 6 +Disruption of postsynaptic signaling by cnv 0.3644553644553653 0.2425212677134353 0.8083762794006581 1.0 0.9910219659598026 6 P27361,Q07157,P61981,Q7L576,P28482 5 +Pyrimidine metabolism and related diseases 0.3612267401311206 0.233432881359539 0.8154252826958341 1.0 0.9930200505762492 6 Q05682,P31350,P11172 3 +Synaptic signaling pathways associated with autism spectrum disorder 0.3774048301268943 0.2117176357206178 0.8323273286650337 1.0 0.9959275871255728 5 P27361,P54619,P49841,P42345 4 +Focal adhesion pi3kaktmtorsignaling pathway 0.2663499151940521 0.208164886050251 0.8351002248740853 1.0 0.9959275871255728 30 Q9Y376,P23588,P11047,Q96B36 4 +Cori cycle 0.2971772177605283 0.2050130870655044 0.8375619001940158 1.0 0.9959275871255728 11 P04406,P11413,P00338 3 +Nrf2 pathway 0.2841892676602762 0.204980141528542 0.8375876403598383 1.0 0.9959275871255728 17 P28161,P48506,P11413,P25685 4 +Exerciseinduced circadian regulation 0.2917584527367916 0.2022243454848709 0.8397413413503887 1.0 0.9959275871255728 14 P31689,Q96PU8,P78344,Q9Y2A7,P25789 5 +Disorders of folate metabolism and transport 0.3362221987793212 0.1945159609149518 0.8457718993985581 1.0 0.9959275871255728 7 Q99707 1 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.2761891546340979 0.188193754285775 0.850724768373363 1.0 0.9959275871255728 18 Q15392 1 +Notch signaling pathway 0.2898962611678519 0.1822099712606092 0.8554179480514856 1.0 0.9959275871255728 11 P40763,Q96J02 2 +Ampactivated protein kinase ampk signaling 0.2886219929773848 0.1783515246174259 0.8584469166092723 1.0 0.9959275871255728 11 Q9Y376,P14635,P13807,P54619 4 +Nucleotide metabolism 0.2838947939264533 0.1667690442418923 0.8675517766573502 1.0 0.9959275871255728 12 P31350,P30520,P23921,P00374,P09884,P30566,P22392 7 +Tcell receptor tcr signaling pathway 0.2885827978242019 0.1597061330056788 0.8731125694792099 1.0 0.9959275871255728 10 P62993,P08670,Q06124 3 +Ciliary landscape 0.2330946037383449 0.1562021110067921 0.8758737128189396 1.0 0.9959275871255728 82 Q9Y312,Q9C0C2,Q9UNS2,P48556,Q9Y6G9,P43246,Q92600,Q8TAG9,Q15555,O60343,Q9BW83,Q9UBW8,P52565,P51665,Q9NTJ3,Q9Y266,Q99627,Q13409,Q96S59,Q9UN37,O00471,P07197 22 +Modulators of tcr signaling and t cell activation 0.302528540912519 0.1453044697051358 0.8844704858658943 1.0 0.9959275871255728 8 P62993,Q93034 2 +Familial partial lipodystrophy fpld 0.3133000426289412 0.1385310272414008 0.889820749816379 1.0 0.9959275871255728 7 Q03252 1 +Bmp signaling in eyelid development 0.4901880621422844 0.1382742152914975 0.8900237029546623 1.0 0.9959275871255728 2 Q12948 1 +Complement system in neuronal development and plasticity 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action rbe2f1 signaling and cdkbetacatenin activity 0.3070235375474683 0.0745499917876045 0.9405727641069204 1.0 0.9959275871255728 5 P11802,P06400 2 +Nanoparticlemediated activation of receptor signaling 0.2829777457868445 0.0679159955078647 0.945852505579332 1.0 0.9959275871255728 6 P62993 1 +Biomarkers for pyrimidine metabolism disorders 0.2821117690062011 0.0666915110180941 0.9468272924932584 1.0 0.9959275871255728 6 P11172,P31350 2 +Preimplantation embryo 0.2743014195136385 0.0662149949881568 0.9472066587002956 1.0 0.9959275871255728 7 P17096,Q92945 2 +Regulation of wnt bcatenin signaling by small molecule compounds 0.4155419222903885 0.063937287262306 0.9490201620627527 1.0 0.9959275871255728 3 P48729,P49841 2 +Nonhomologous end joining 0.4134969325153406 0.0620722319700892 0.9505053100219084 1.0 0.9959275871255728 3 P12956,P13010 2 +Mammary gland development pathway involution stage 4 of 4 0.4107083035296003 0.0595973009470352 0.9524763680818468 1.0 0.9959275871255728 3 P40763 1 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0.98623537504697 1.0 0.9959275871255728 9 P62993 1 +Nucleotide excision repair in xeroderma pigmentosum 0.2190887498948091 0.0169881650106239 0.9864460573643464 1.0 0.9959275871255728 23 P15927,P41440 2 +Oxidative damage response 0.2964022894521756 0.012735802475814 0.9898385745341832 1.0 0.9959275871255728 2 P60953 1 +Hedgehog signaling pathway wp4249 0.311656441717787 0.0126045756604124 0.9899432699801698 1.0 0.9959275871255728 3 P48729,P17612 2 +Nicotine effect on dopaminergic neurons 0.2999970535705629 0.0107516161313977 0.991421616758315 1.0 0.9959275871255728 3 Q00535 1 +Integrated cancer pathway 0.2072356202158305 0.0093642522986681 0.9925285168623456 1.0 0.9959275871255728 14 P06493,P52701,Q07812,P11802,P43246 5 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d23351c45a2370ab1d1416f763dc16fc95d2db54 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical and noncanonical tgfb signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Lipid metabolism pathway", "Lipid particles composition", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirna targets in ecm and membrane receptors", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR3", "ADAR", "ADH5", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCY", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APLP2", "APMAP", "APOC3", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AURKA", "BAIAP2", "BANF1", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCL2L13", "BCLAF1", "BLM", "BLVRA", "BPTF", "BRCA1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "C15orf39", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK4", "CDK5", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CKB", "CLASP1", "CLCN7", "CLIC1", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DARS", "DCAF1", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMD", "EML4", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERCC2", "ERI1", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FEN1", "FGFR1OP", "FH", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXC1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GAMT", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GCLC", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GNA13", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "IMPDH2", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIF20B", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC1", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMC1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG3", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSS", "LTA4H", "LUC7L", "MACF1", "MANF", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME2", "MECP2", "MED1", "MEPCE", "MGA", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPDU1", "MPI", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NEFM", "NEK9", "NELFA", "NELFB", "NEO1", "NEU1", "NKRF", "NME1", "NME2", "NONO", "NOP2", "NPC2", "NRP1", "NSDHL", "NSF", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP88", "NUP98", "NXF1", "OAT", "OGDH", "OGT", "OPA1", "ORC5", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAICS", "PAK2", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDLIM5", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PIK3R4", "PIN1", "PKM", "PKN2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PNP", "PNPT1", "PODXL", "POLA1", "POLD1", "POLDIP2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB14", "RAB21", "RAB2A", "RAB3B", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RARS", "RB1", "RBBP7", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RBPJ", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RIF1", "RNASEH2B", "RNASET2", "RNF20", "RNF40", "RNMT", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC24A", "SEC24C", "SEC31A", "SEL1L", "SEPT11", "SEPT8", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SKP1", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC3A2", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SOD2", "SORT1", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "STAG2", "STAT1", "STAT3", "STIP1", "STMN1", "STRAP", "STUB1", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT5H", "SUZ12", "TAB1", "TALDO1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCP1", "TECR", "TELO2", "TERF2", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMEM43", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRIP4", "TRMT2A", "TRRAP", "TSG101", "TTC19", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWISTNB", "TXNDC5", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UCHL5", "UCK2", "UFD1", "UGGT1", "UGP2", "UHRF1", "UMPS", "UPF1", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS33A", "VPS4A", "WARS", "WDHD1", "WDR1", "WDR26", "WDR5", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", 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"DPYSL2", "DYNC1I2", "DYNC1LI1", "EEA1", "EEF1B2", "EEF1D", "EEF1E1", "EHD1", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3H", "EIF3J", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "EML4", "EPHX2", "EPS15", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EZR", "F11R", "FAM120A", "FANCD2", "FANCI", "FEN1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FNTA", "FOXC1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GAMT", "GAPDH", "GART", "GCLC", "GIGYF2", "GRB2", "GSK3B", "GSTM2", "GYS1", "HDAC1", "HDGF", "HMGA1", "HMGB1", "HPRT1", "HSD17B7", "HSP90AA1", "HSPA2", "HSPB1", "IDH1", "IDH2", "IFT27", "ITCH", "ITPA", "KDM1B", "KHDRBS1", "KHSRP", "KIF5B", "LAMC1", "LARP1", "LDHA", "LEMD3", "LGALS3", "LMAN1", "LMNB2", "LTA4H", "MANF", "MAP2K1", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MAT2A", "MCM3", "MCM4", "MCM7", "MEPCE", "MIA3", "MIF", "MSH2", "MSH6", "MSN", "MTOR", "MTR", "MYH10", "MYH9", "NAA40", "NAMPT", "NARS", "NCKAP1", "NEFM", "NELFA", "NELFB", "NME2", "NUDC", "P4HA2", 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27.921792815732285 1.1069658442061727 0.352537539057648 1.0 0.5350487292387283 0.0052224585565179 1.6589208763628783e-05 7.406678388065592e-11 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9e5bb6135276a69d1663ac1b69fbb1c1f6357d30 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 77.76470588235294 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..69cf0d8a36b44c7f63ce81b915a29542a0602080 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2d269502d82601b38268e83c55af9a9c244c50e6 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,12 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +cytoplasmic 0.4285481536959881 4.61212724142381 3.9856887610323355e-06 6.77545485233943e-05 6.775670893756671e-05 330 Q8WWM7,P04792,Q7L2H7,P62861,O15144,O95373,O95861,P61586,P33176,P50995,P35579,P31948,P14174,P30260,Q04917,Q99439,Q14247,Q9UDY2,Q99460,P28072,P28074,Q9UL46,P28070,P30876,P53680,O00231,P55010,O43237,P14635,Q99436,P31689,P46379,P51665,Q02952,P78362,P60953,Q9UBF8,P60842,P61923,Q96B36,Q9H2J4,Q13685,Q15691,Q13177,Q9UJX2,P18206,O00410,Q9NT62,Q9NVZ3,O43633,P54105,Q9UQB8,Q7Z4Q2,Q15427,O76094,Q96KB5,Q8N6T3,Q9Y3A5,P84098,P98179,Q13596,O43683,Q15075,Q16637,O75340,Q9NZB2,P31150,Q9Y3C8,P40616,Q5JTV8,P49721,Q8WUM4,Q99961,Q9UN86,Q9UNM6,Q14974,P06493,P17612,P26038,P20290,P35998,P42766,P49591,P68371,P25685,P63104,Q7Z460,P20618,Q92598,Q9NVA2,Q13409,Q9UBF2,Q9UI12,P20339,Q9Y678,O43242,Q15185,O95757,P0DP25,O60869,O43592,P09132,Q96AX1,Q9UHB9,P61221,O60684,Q8TEX9,Q92973,O60749,Q9Y6G9,P25789,P17812,P62993,P25787,Q9Y5X3,P61081,O15212,P52732,Q99816,P55884,Q96A49,P11413,Q13310,Q00535,P46777,P11802,Q92530,P60228,P00338,Q13200,Q8WXX5,P42566,P09497,P30626,Q96EK5,Q7Z417,O95456,P43487,P51116,Q05682,Q92900,Q9UBB4,P50570,P13807,Q96S59,Q9UN37,P04406,Q5VYK3,P60900,Q15008,Q15418,Q06323 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sha256:6afe62cf3604c359d23d139453d4212898db73ea6e069228b428d51f99265fd2 +size 135551 diff --git a/panther_protein_class/consensus.joblib b/panther_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..3e25755834e8db62979eac86aa6bf1cf42bef0f5 --- /dev/null +++ b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a5c01c237e59f80c399324633ded83832dcbeeaa35c03bf54aeae9dcad67edfa +size 61287 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b636e2f9ad4147d8488dbf5b6d6087d0b1a507a8 --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +ubiquitin-protein ligase 27 49 2.5881129839455057 0.0096503321714527 19.58495145631068 59.20631067961165 -0.4503192177737564 0.5340766328058972 8.123146046740304 8.77461359094909 1.127183081820805 0.3533429799231634 1.0 0.4775983043258186 0.8118448998006106 0.1979363004503066 0.012450996601949 +translation initiation factor 15 41 2.524289522526673 0.0115932405013376 12.444174757281552 44.851941747572816 0.1145008827355917 0.6467304989659429 6.887394567659453 2.159854614961781 0.9002593912782545 0.3253626339773532 1.0 0.1723563940014431 0.0841094921706975 0.0125938669716006 5.725061480520839e-06 +transmembrane signal receptor 2 5 2.317684807130324 0.02046645731848 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 1.0 0.2383836022925792 0.1530920120382657 0.3241466145304874 0.805551418352152 +calmodulin-related 7 11 2.311609038841518 0.0207992380763268 5.053398058252427 12.385922330097088 1.3935892727836532 0.1814075830019033 2.0222219603900085 1.786979844553702 1.206053991839631 0.2252292235861566 1.0 1.0 1.0 0.0164525276609661 0.0001011654339153 +transporter 11 52 2.1763188879801407 0.0295314241639892 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 1.0 0.046091594340716 0.0002451856844065 0.0138832761544047 0.0078312438453126 +protease 14 40 2.072431902868846 0.0382251807323481 10.902912621359222 40.48300970873787 0.4803723668923849 0.5637578889383219 6.152613404953344 2.1366434682897735 1.0933280509795595 0.3608053434874421 1.0 1.0 0.0015203947642566 0.0005521145275289 2.335233007283631e-07 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..189ff3029825183e8aee71a00c8847fc844de6c6 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 154, + "title": "Average number of proteins per term", + "value": 11.376623376623376 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..11a93fd10cd5fe91db86a5cc25d1ff4bfb8e656b --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b03ea4a73b8aa65eda8026cd947c730bbd0f28d7 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,53 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +ubiquitin-protein ligase 0.5092371462479851 2.5881129839455057 0.0096503321714527 0.775385246648673 0.2911893330685764 49 Q9NT62,Q9UBT2,Q7Z6E9,Q16763,Q15386,P19474,P68036,Q9ULT8,O94874,P30260,Q9Y4X5,Q9HB71,P61081,Q8TBC4,A0AVT1,Q99816,P63208,O75592,Q93034,Q5T4S7,Q7Z6Z7,Q96T88,Q12899,Q9UJX2,Q5TAQ9,Q96J02,Q14139 27 +translation initiation factor 0.5172832640014274 2.524289522526673 0.0115932405013376 0.8340035329271942 0.2911893330685764 41 O75153,P60228,P55884,Q9UI10,P78344,P56537,P51665,P23588,Q9NR50,O75822,Q9Y262,P05198,Q04637,P55010,P06730 15 +transmembrane signal receptor 0.9164247227861634 2.317684807130324 0.02046645731848 0.9586025010930784 0.2911893330685764 5 Q99720,Q8WUJ1 2 +calmodulin-related 0.7269732770641215 2.311609038841518 0.0207992380763268 0.9607130440107776 0.2911893330685764 11 Q14257,P30626,P31949,P80303,P0DP25,Q02818,Q99584 7 +transporter 0.4578256746763593 2.1763188879801407 0.0295314241639892 0.9901111108763596 0.3626073595052854 52 Q8TEX9,O43772,Q92973,P41440,Q9H2D1,Q567V2,Q8NFH4,Q6N075,Q9NR77,O60830,O60684 11 +protease 0.470867829099981 2.072431902868846 0.0382251807323481 0.9975265452553688 0.3924451888521076 40 P61009,Q99436,Q9UNS2,Q9UJ14,P25787,P49721,P48556,O43242,P28072,P28074,Q13200,P28070,P25789,P20618 14 +membrane traffic protein 0.4358929029884231 1.8802740193323375 0.0600707422315793 0.9999281120782016 0.4405187763649155 47 P42566,O43633,P50570,Q92734,A6NIH7,Q8TAG9,Q9H4M9,Q9NUQ3,P20645,Q9H223,Q9Y296,Q9Y2T2,Q9BXS5,Q5JRA6 14 +actin or actin-binding cytoskeletal protein 0.5593998796525176 1.759842919129438 0.078434443746048 0.999996556182604 0.4645732437265921 17 O75340,P15311,Q9NYL9,Q01518,P35241,Q15942,Q96HC4,O15143,O00151,Q92747 10 +apolipoprotein 0.9370400654129212 1.67661782376399 0.0936172391154464 0.9999997333190058 0.4712491451783722 2 P02656 1 +GTPase-activating protein 0.595588118156108 1.6518569639226672 0.0985637129990846 0.9999998851857972 0.4712491451783722 11 Q8N6T3,Q8TC07,Q15042 3 +translation elongation factor 0.5682412256454159 1.5883776997436454 0.1122009570385975 0.999999989023609 0.4712491451783722 13 P29692,O43324,P24534,O00178,P43897 5 +DNA helicase 0.597144212615918 1.485266736400695 0.1374731796957213 0.9999999998714768 0.4766393214369231 9 Q9H4L7 1 +chaperone 0.3766363629973527 1.4115569638579222 0.1580804517266134 0.9999999999968978 0.5144846978790513 54 Q9UHV9,Q14203,Q99471,P61758,Q8WXX5,Q13526,Q9Y3C6,Q02790,Q5TC12,P49321,O95456,P31689,P46379,Q9BTW9,P25685,Q9H2H8,O75937,Q13451,Q9NVH1,Q15813 20 +protein modifying enzyme 0.463297576738147 1.399376718364113 0.1617000446711536 0.9999999999984024 0.5144846978790513 21 Q86X55,O60568,Q99873,Q9UMR5,O14744,Q15418,O75718,O60678,O15460 9 +RNA methyltransferase 0.5707405874508117 1.3558091046671406 0.1751599136937041 0.999999999999868 0.527672487632673 9 Q8IZ69,Q9BV44,O75648 3 +histone modifying enzyme 0.5220678118768975 1.299048608345346 0.1939272481495231 0.9999999999999962 0.5332999324111886 12 Q9H7B4 1 +protein-binding activity modulator 0.6935351882160281 1.1620105628379578 0.2452311743501596 1.0 0.6400949296597387 4 O14737,P14314,Q9UNZ2 3 +G-protein 0.6430289940392215 0.9616993485903592 0.3362006496800811 1.0 0.7537217598266569 4 P40616,Q9NTK5 2 +transcription cofactor 0.4735357624840418 0.9415097173626664 0.3464437118664563 1.0 0.7563429770258286 10 Q13363,P51858 2 +small GTPase 0.5003393433734924 0.9027431534726028 0.3666622277206137 1.0 0.7735066173832126 8 Q3YEC7,P61586,P11233 3 +methyltransferase 0.4470090165294836 0.8725368298433818 0.3829155851789769 1.0 0.7862533349008327 11 P34896 1 +nucleic acid metabolism protein 0.6061361828159287 0.8181631142574883 0.4132640540634773 1.0 0.8089749977843936 4 P49750 1 +primary active transporter 0.3896903599416549 0.7806909570378625 0.4349842805168249 1.0 0.8134959837299457 18 O60888 1 +nucleotide phosphatase 0.5421424167292694 0.7786463421905991 0.4361880723193809 1.0 0.8134959837299457 5 Q5TFE4 1 +phosphatase 0.4389790507604141 0.7696806042283258 0.4414893782029503 1.0 0.8134959837299457 10 Q9H773 1 +general transcription factor 0.3974205935196627 0.7414147839068156 0.4584419832850246 1.0 0.8134959837299457 16 P53999,Q9Y5Q8,Q6PD62,Q9ULK4 4 +basic leucine zipper transcription factor 0.7015535568274782 0.7395511264792843 0.4595724063928914 1.0 0.8134959837299457 2 Q9Y6E2 1 +non-motor actin binding protein 0.3426332290422828 0.6871480397932618 0.4919894438840395 1.0 0.8176531795105467 27 Q14019,Q9Y281,Q99439 3 +primase 0.6868356500408885 0.6853612836769779 0.4931159687979427 1.0 0.8176531795105467 2 P49642 1 +decarboxylase 0.5119347821400325 0.6585030589678799 0.5102149320684672 1.0 0.8184697868598328 5 P14174 1 +G-protein modulator 0.6718477086216963 0.6491290579960707 0.5162549612007552 1.0 0.8196212786073845 3 P52565 1 +scaffold/adaptor protein 0.2906729325010882 0.5742540539837432 0.5657958958433407 1.0 0.8542408623517104 56 O60664,Q9UQB8,Q5BKZ1,Q9Y2I1,O60828,O60749,Q9UQ13,Q8WX93,Q04917,O60271,Q9Y5X3,P43487,P35613,Q9H6Z4,Q02952,Q99627,Q96S59,Q9ULX6,Q9NZW5,Q5VYK3 20 +oxidoreductase 0.3044219450898613 0.5459024711219621 0.585132979644813 1.0 0.8748590181097206 38 Q8N4Q0,P04179,O95831,P22570,Q9Y320 5 +cytoskeletal protein 0.4771515070131565 0.5264732940312052 0.5985594026011962 1.0 0.8763121722249556 5 Q92599,Q9NVA2,Q9UHD8 3 +acetyltransferase 0.3437963241762382 0.3786039850047367 0.7049819624897713 1.0 0.9180385192120006 11 Q5VZE5,P41227 2 +phosphatase modulator 0.4792691066776813 0.3725750629711816 0.7094647354924857 1.0 0.9180385192120006 4 Q5H9R7 1 +vesicle coat protein 0.3038884557681889 0.3664507975442137 0.7140287208059908 1.0 0.9180385192120006 21 P35606,P09497,O95486,Q9UBF2,Q9Y678,Q15436,Q9BVK6,Q92572,P53680,P61923,P53621 11 +guanyl-nucleotide exchange factor 0.4753873987087685 0.3608836775205514 0.7181864059588845 1.0 0.9180385192120006 4 Q14C86 1 +mutase 0.401940554115866 0.3593097288336768 0.7193633970848368 1.0 0.9180385192120006 6 Q96G03,O95394,P36871 3 +nucleotide kinase 0.3338967276468951 0.3465336081870207 0.7289417312995441 1.0 0.9180385192120006 12 P30085,Q9BZX2,Q13126,O60256 4 +translational protein 0.5727718724448166 0.3177592292603681 0.7506675793039663 1.0 0.9248224577024864 2 P54577 1 +transferase 0.2902029165486587 0.3026155055528782 0.7621828964997008 1.0 0.925582442784234 23 Q7LGA3,P07741,P49903,Q9NRN7,P11172,P43490,P28161 7 +microtubule or microtubule-binding cytoskeletal protein 0.3173781107038432 0.2475930662954831 0.8044492760180102 1.0 0.9477084824248138 10 Q13409,Q8IWJ2,Q9Y6G9,Q9Y266,O43237 5 +translation factor 0.3644553644553668 0.2425212677134396 0.8083762794006548 1.0 0.9477084824248138 6 Q9Y450,Q05639,P51116,P51114,P15170 5 +kinase modulator 0.3766090630258961 0.2097241567115984 0.8338829704736639 1.0 0.9477084824248138 5 P54619,Q99570 2 +chromatin/chromatin-binding, or -regulatory protein 0.2622518213588033 0.2025038932831622 0.8395228150626395 1.0 0.9477084824248138 34 Q13610,Q15645,Q8N3U4,Q9UPN9,Q15021,Q92688,Q9BTT0,P05204,Q13112,P16383,O75717,O00422,Q99733,P06400,Q01105,Q15014 16 +extracellular matrix protein 0.4068423557464895 0.1835183394166264 0.8543913303569659 1.0 0.9502452396004591 4 P11047 1 +non-motor microtubule binding protein 0.2835083158477479 0.1744881431303718 0.8614818482445508 1.0 0.9502452396004591 14 Q15691,Q15555 2 +RNA splicing factor 0.2254839667312064 0.1090699787901247 0.9131469862558764 1.0 0.9729948131333732 74 Q9Y312,O43719,Q15428,Q13247,Q8WWY3,Q9NTZ6,P62312,Q15637,Q8NCA5,Q12872,Q8WXF0,Q14331,Q9Y4C8,Q16637,Q07666 15 +kinase inhibitor 0.4437627811860993 0.0942079987895118 0.9249439309207012 1.0 0.9756257901492328 3 Q9NQG5,Q5VT52 2 +deaminase 0.3295175797220028 0.0163568169405076 0.9869497302252908 1.0 1.0 2 P52758 1 +DNA-binding transcription factor 0.2067458474635354 0.0069991656255187 0.9944155194046536 1.0 1.0 15 P20290,P40763 2 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b255c5ee1f11f4e5808b6381758c43c90ccb672d --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCY", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "ANAPC1", "ANAPC7", "ANGEL1", "ANKFY1", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOC3", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARIH1", "ARL1", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD5", "ATG3", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BDH2", "BLM", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDKN2AIP", "CDS2", "CEBPZ", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSTB", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBT", "DCAF13", "DCAF8", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENO1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FH", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GGT7", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPI", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAP1S", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MECP2", "MED1", "MED23", "METAP2", "METTL13", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MPHOSPH10", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH2", "MTOR", "MTPAP", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCOA5", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NENF", "NEU1", "NFS1", "NHP2", "NIP7", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B3", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PES1", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHF10", "PHF14", "PHF3", "PHF6", "PHGDH", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP1", "RABGAP1", "RABL6", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RNMT", "ROCK1", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC4A1AP", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPTLC1", "SPTLC2", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG2", "STAT1", "STAT3", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TERF2IP", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TJP1", "TJP2", "TK1", "TKT", "TM9SF2", "TM9SF3", "TMED10", "TMED7", "TMED9", "TMOD3", "TMPO", "TMX2", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAP1", "TRAPPC4", "TRIM21", "TRIM26", "TRIM27", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSTA3", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", 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0000000000000000000000000000000000000000..1340c1be4596e1b0929dbc65cbad77c5c256766b --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Translation factor 14 25 2.9551258752307854 0.0031254150563702 6.951456310679611 26.34223300970874 0.3217105737724597 0.5885494153132408 5.03989644056169 1.243180568658069 0.9262525781273792 0.3373319193546022 1.0 0.1113866273120098 0.0364979353001365 0.0016540991371799 1.4539343153104505e-08 +Translation initiation factor 11 20 2.6912532536910394 0.0071184134331012 5.283980582524272 20.803398058252423 0.4565236500219777 0.559881468182603 3.9896024669487 1.082826267249171 0.8934418568512774 0.3359596376002439 1.0 0.0792956380768977 0.0187430821816874 0.0029707405717312 2.541141225832729e-07 +Signaling 6 15 2.554549797061787 0.0106325219753311 5.66747572815534 18.009708737864077 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"results/proteins/hek293t_core/pharos_dto/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2d628fed2074f3ed78e5279fa04bd4b2b3856b81 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,62 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Translation factor 0.67712772657916 2.9551258752307854 0.0031254150563702 0.994340396163836 0.068194539636195 25 O75153,P60228,P29692,P55884,P78344,P56537,P23588,O75822,Q9Y262,P05198,P24534,Q04637,P55010,P43897 14 +Translation initiation factor 0.6706173900854413 2.6912532536910394 0.0071184134331012 0.9999925613224246 0.068194539636195 20 O75153,P60228,P55884,P78344,P56537,P23588,O75822,Q9Y262,P05198,Q04637,P55010 11 +Signaling 0.7281614999445319 2.554549797061787 0.0106325219753311 0.9999999788084372 0.0714792660690754 15 Q99627,Q8WUJ1,P51858,P43490,Q5JRA6,Q7Z4V5 6 +Intracellular calcium-sensing protein 0.7132896353324468 2.295371103228238 0.0217118659292028 0.9999999999999998 0.0937068260599798 12 P31949,P80303,P0DP25,Q02818,Q99584 5 +Calmodulin 0.7132896353324468 2.295371103228238 0.0217118659292028 0.9999999999999998 0.0937068260599798 12 P31949,P80303,P0DP25,Q02818,Q99584 5 +Writer 0.7195559833957091 2.070056917275033 0.0384470147353943 1.0 0.1274744430791864 9 Q9H9B1,Q99873,O14744,Q9H7B4,O60678 5 +Calcium-binding protein 0.6219307784937924 2.0489624611009036 0.04046578577822 1.0 0.1307542703477672 16 Q14257,Q9Y376,P31949,P80303,P0DP25,Q02818,Q99584 7 +Protein methyltransferase 0.7266404133667335 1.9562176649255831 0.0504395184372075 1.0 0.1486212548604349 8 Q9H9B1,Q99873,O14744,Q9H7B4,O60678 5 +SLC superfamily of solute carriers 0.4853070899787264 1.904626247955018 0.0568286721345028 1.0 0.1592166017598867 33 Q70HW3,O43772,P41440,Q5T1Q4,O00400,O95563,Q6N075 7 +Receptor 0.565199942357879 1.870156168400828 0.0614621344468748 1.0 0.1658739423122285 18 A6NIH7,Q9UQB8,Q567V2,P20645,Q9NR77 5 +Ubiquitin-protein ligase 0.6028877348821889 1.7303043791557962 0.0835759075665922 1.0 0.1970769974430485 12 Q99816,Q9Y4X5,Q9HB71,Q93034,Q96J02 5 +Phosphatase modulator 0.7016532093637203 1.7088067554149282 0.0874867509845711 1.0 0.2033974674788974 7 Q92688,Q9BTT0,Q99733,Q15257,Q01105 5 +Protein arginine methyltransferase 0.8256955810147263 1.6879669771323116 0.0914175682186106 1.0 0.2089373445555906 4 O60678,Q99873,O14744 3 +DNA helicase 0.599121014438986 1.670145596301961 0.0948905607423684 1.0 0.21311697949339 11 Q9H4L7 1 +Nucleoside kinase 0.9324359076077812 1.598651850665072 0.1098979817983925 1.0 0.2350082327461096 3 P55263 1 +G-protein modulator 0.4951707983881201 1.510120379310827 0.1310127102741409 1.0 0.2599808044215546 19 P42566,P43487,Q9H4M9,Q96D71,P52565,O14530,Q9H223,Q9H6Z4,Q15436,O00410,Q14C86 11 +Growth factor 0.7771323475818201 1.4957446704962976 0.1347202047079503 1.0 0.2638536710690069 4 P51858,Q5JRA6 2 +Enzyme modulator 0.3466951832307517 1.488719115674625 0.1365613491344433 1.0 0.2655716589638056 87 Q9UNS2,Q9Y2I1,P48556,Q13200,O95373,Q99733,P61586,P11233,Q01105,P42566,O60271,Q99460,Q9BTT0,P55060,Q15257,P14635,P43487,Q9H4M9,P46379,P52565,Q92688,Q9NTK5,Q9H223,O14737,Q9H6Z4,P60953,P50570,P35237,Q5H9R7,O43242,Q15942,P11047,Q5TAQ9,Q15436,Q92530,Q14139 36 +mRNA splicing factor 0.3736267515002338 1.459447024971323 0.1444421111184035 1.0 0.2733181207209647 58 P35637,Q15428,Q13247,P62312,Q8WXF0,P98179,Q01844,Q92804 8 +Epigenetic regulator 0.4474415994763475 1.430922181922593 0.1524525189454992 1.0 0.2836556325099287 26 Q8NB78,Q99873,O14744,Q9H7B4,O60678,Q16637 6 +Phosphatase inhibitor 0.6911689947945647 1.4012534734513862 0.1611382889185086 1.0 0.2923837448762841 5 Q01105,Q92688,Q99733 3 +Nucleotide phosphatase 0.6263767286407237 1.3719303875886169 0.1700851095134528 1.0 0.3010178651239159 7 Q8IWA4,Q5TFE4 2 +CDK family 0.7115384615384546 1.233904660351252 0.2172384327446561 1.0 0.3544868009150213 4 P11802,Q9NYV4,Q00535 3 +Non-motor actin binding protein 0.4328552677386253 1.2137075231594077 0.2248594305173736 1.0 0.3608666394613773 22 Q9NYL9,P37802,Q99439,Q14247,Q14019,Q96HC4,O00151 7 +Translation elongation factor 0.8077709611451925 1.134528323631243 0.2565729998259738 1.0 0.3919733537082576 3 P29692,P43897 2 +Transporter 0.2954680748847814 1.0144716795943645 0.3103577363166596 1.0 0.447272308745805 144 O60664,Q8TEX9,O43772,Q92973,Q5T1Q4,Q9BQE5,Q15075,Q8TAG9,O00400,O95563,Q6N075,P35606,P41440,Q9UNZ2,Q70HW3,Q9H2D1,Q9BVK6,O00471,Q8NFH4,Q96AX1,O60684 21 +Chromatin/chromatin-binding protein 0.4346757751723262 1.0046913626455896 0.3150454885122067 1.0 0.4524502106956365 17 P09429,Q8N3U4,P05204,Q8WXI9,O00422,O15347,Q15014 7 +Actin family cytoskeletal protein 0.3535626372867704 0.9899372014750286 0.322204814682923 1.0 0.4591418609231654 39 P15311,Q9NYL9,Q01518,Q99439,Q14247,P35241,Q14019,Q96HC4,O15143,O00151,Q92747 11 +mRNA processing factor 0.3076303708406895 0.9439720650154172 0.345183923617395 1.0 0.4790839846679714 72 P35637,Q15428,Q13247,P62312,Q8WXF0,P98179,Q14011,Q01844,Q92804 9 +Extracellular matrix glycoprotein 0.6339914193039783 0.926243693450478 0.354319350319956 1.0 0.4868814728826363 4 Q9BXS5 1 +Nuclease 0.3552478136512234 0.8401371168077645 0.4008315112515619 1.0 0.5221233160747296 32 Q9UPY3,Q9UQ84 2 +SLC25 family of mitochondrial transporters 0.4065896659057166 0.8360938878486195 0.4031020866233095 1.0 0.5234310677048944 17 Q70HW3,O43772 2 +V-type ATPase 0.5041146645735677 0.8219768787973456 0.4110900561720139 1.0 0.5304698382922239 7 P21281,Q9Y487,Q93050,Q9UI12 4 +Non-protein kinase 0.4027048051722053 0.6663113598032998 0.5052121061142696 1.0 0.6013637030153076 12 Q9UBF8,P55263 2 +STE group 0.666541242934365 0.6314189178274293 0.527766649727317 1.0 0.6184632983517079 3 Q13177 1 +Helicase 0.3549176222048592 0.6160686499373795 0.537849211970999 1.0 0.6239283528159907 19 Q9H4L7 1 +Membrane trafficking regulatory protein 0.3805932911722129 0.5953458112902559 0.5516123395632078 1.0 0.631013977368846 14 Q96AX1,Q15075,O00471,Q9UNZ2 4 +Non-motor microtubule binding protein 0.381995753401225 0.5816433998594741 0.5608069033562855 1.0 0.6355266018046061 13 Q15691,Q9BTW9,Q15555 3 +Antibacterial response protein 0.6512673753066294 0.5595545828081379 0.5757832908969711 1.0 0.6461437745096356 2 Q9NUQ3 1 +Transcription cofactor 0.377678377272974 0.4834418006698355 0.6287820741410088 1.0 0.6780018059720077 10 Q13363 1 +Acyltransferase 0.4226035752856605 0.4814928440157781 0.6301662644407389 1.0 0.6783051333981018 7 P49354 1 +Kinase modulator 0.3741290322997944 0.4680107070157283 0.6397769329129421 1.0 0.6816223004666863 10 P14635,Q15942,O60271 3 +Kinase activator 0.5921957953369588 0.401146756614123 0.6883120782140075 1.0 0.7128946524359363 3 P14635 1 +Reductase 0.3434113481274331 0.3986506233950043 0.6901506549702174 1.0 0.7143513041113146 13 P31350,P23921,Q15392,P00374,Q9UBM7 5 +Mitochondrial nucleotide transporter subfamily 0.3959464653992635 0.3820913594774558 0.7023936006247877 1.0 0.7256603886454839 7 Q70HW3,O43808,Q9H2D1 3 +Esterase 0.3583406155104771 0.3671939337240434 0.7134743639547723 1.0 0.7366477973874069 9 Q9UMR5 1 +Extracellular structure 0.3820054342889041 0.3335336927023685 0.7387314608835318 1.0 0.7608243643865907 7 Q9BXS5,O75718 2 +Intracellular chloride channel (clic) family 0.5633687653311619 0.2930169588484958 0.7695091890519343 1.0 0.7900612978278555 2 Q9Y696 1 +AGC group 0.3937781416291458 0.2548288016699926 0.7988553289467819 1.0 0.819682097299212 5 Q16513,Q15418,P17612,P51812 4 +G-protein 0.2696605213851207 0.2077352671356445 0.8354356791274338 1.0 0.8535075263273473 25 P50570,Q5TAQ9,Q9NTK5,P55060,O95373,P61586,P11233 7 +Cell adhesion 0.3599191312301749 0.170175437350062 0.8648721681042106 1.0 0.8803163139632144 5 Q9UNF1,Q96MG7 2 +Cellular structure 0.234446575689884 0.167535781163238 0.8669484960717444 1.0 0.881886685542519 85 Q9NYL9,Q14019,Q9Y6G9,O15143,Q15149,O43264,P33176,Q15555,Q99439,Q14247,Q01518,P35241,Q96HC4,P59998,O00151,O43237,P52732,P37802,P15311,P26038,Q9BTW9,Q9Y266,Q9BUF5,P68371,Q7Z460,Q8NI77,Q13409,Q9UN37,Q15691,Q92747 30 +Small GTPase 0.2605393372285189 0.1576009308038496 0.874771270064924 1.0 0.888750405296447 21 P50570,Q9NVA2,P60953,Q9UHD8,Q92599,P55060,O95373,P61586,P11233 9 +Vesicle coat protein 0.2542677061077401 0.1340637841867741 0.8933521370999966 1.0 0.904847477099445 20 P35606,P09497,O95486,Q9UBF2,Q9Y678,Q9BVK6,Q92572,P53680,P61923,P53621 10 +Guanyl-nucleotide exchange factor 0.4280457890433484 0.0611865904434356 0.9512106089990108 1.0 0.9610948268186827 2 Q14C86 1 +CMGC group 0.2323325984621471 0.0462366856545699 0.9631216028055204 1.0 0.972535130994212 13 P11802,Q9NYV4,Q00535,P78362 4 +Chaperone 0.2300137962564384 0.0453383064537732 0.963837654682467 1.0 0.9726640068315738 35 Q5TC12,Q14203,Q15813,Q99471,P61758 5 +Zinc finger transcription factor 0.2579852579852527 0.0376343032855122 0.9699792572195324 1.0 0.9782646200023716 6 O95785,Q8WU90,Q7Z3K3,Q9Y2X9,O94880 5 +Immune response 0.2590211522489771 0.0254081492054738 0.9797294110815238 1.0 0.9856692030566958 5 Q9NUQ3,P40222 2 +DNA binding protein 0.2207104214471812 0.0246895592232756 0.9803025830763508 1.0 0.9856692030566958 49 Q9Y5Q8,P17096,P05204,Q8WXI9,P54727,P43246,O15347,Q15014 8 +BUB family 0.3479149632052413 0.01998021022868 0.9840591593646424 1.0 0.9882441011116364 2 O43683 1 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ff1f331191915532b3dc85620a7d9e83bfa07bed --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase inhibitor, mitochondrial", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Activating signal cointegrator 1", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Annexin", "Antibacterial response protein", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis regulator BAX", "Apoptosis-inducing factor 1, mitochondrial", "Arginase-2, mitochondrial", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMKL family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-regulated heat-stable protein 1", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Caprin-1", "Carbohydrate kinase", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell surface glycoprotein MUC18", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centromere/kinetochore protein zw10 homolog", "Chaperone", "Chaperonin", "Charged multivesicular body protein 5", "Charged multivesicular body protein 6", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "ClC-7/CLCN7 subfamily", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 2 tau variant", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 4", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DDB1- and CUL4-associated factor 8", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh6", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyribonuclease-2-alpha", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmocollin-3", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase listerin", "EF-hand domain-containing protein D1", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongin-B", "Endodeoxyribonuclease", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Epidermal growth factor receptor substrate 15", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Esterase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 5", "Exocyst complex component 6", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Flap endonuclease 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-protein", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GC-rich sequence DNA-binding factor 2", "GDP-L-fucose synthase", "GDP-fucose protein O-fucosyltransferase 2", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General vesicular transport factor p115", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutathione hydrolase 7", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HEAT repeat-containing protein 1", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase EHMT2", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF20B", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit gamma-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "M-phase phosphoprotein 8", "MAGUK p55 subfamily member 6", "MAPK family", "MAX gene-associated protein", "MCU family", "MMS19 nucleotide excision repair protein homolog", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Mannose-6-phosphate isomerase", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methyltransferase", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitogen-activated protein kinase 3", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PEK family", "PH-interacting protein", "PHD finger protein 10", "PHD finger protein 14", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PKA family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Peptidyl-prolyl cis-trans isomerase-like 3", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FRG1", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SET", "Protein Wiz", "Protein angel homolog 1", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1G", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein unc-119 homolog B", "Protein/nucleic acid deglycase DJ-1", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rac GTPase-activating protein 1", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Recombining binding protein suppressor of hairless", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-related GTP-binding protein RhoG", "Ribonuclease P protein subunit p30", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC61 Molybdate transporter family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-7", "Septin-8", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 12", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase vrk2", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sialic acid synthase", "Sialidase-1", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 19 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 25 member 44", "Solute carrier family 35 member F1", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 15", "TBC1 domain family member 4", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "TK group", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UDP-glucuronic acid decarboxylase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 33", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "YEATS domain-containing protein 2", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD6", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ANAPC1", "ANGEL1", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "ARCN1", "ARG2", "ARHGDIA", "ARIH1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD3A", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BAX", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRIX1", "BUB1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDK1", "CDK12", "CDK4", "CDK5", "CDKN2AIP", "CEBPZ", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBT", "DCAF13", "DCAF8", "DCPS", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX40", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENO1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FNTA", "FOXC1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GGT7", "GLB1", "GLDC", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNPDA1", "GNS", "GOLGA2", "GPATCH4", "GPD2", "GPI", "GRPEL1", "GRSF1", "GSK3B", "GSPT1", "GSR", "GSS", "GTF3C3", "GTF3C5", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HEATR1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LTN1", "M6PR", "MACF1", "MAGED2", "MAP1S", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MAT2A", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "ME2", "MECP2", "MFN1", "MFSD5", "MGA", "MGST2", "MGST3", "MIA3", "MIPEP", "MMS19", "MORF4L1", "MORF4L2", "MPC2", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL38", "MRPL39", "MRPL44", "MRPL47", "MRPL49", "MRPL9", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NEK9", "NEU1", "NFS1", "NHP2", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OLA1", "OPA1", "ORC5", "OSGEP", "OTUB1", "OXCT1", "P3H1", "PACSIN2", "PAICS", "PAK2", "PANK4", "PAPSS1", "PARK7", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD11", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDHX", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PES1", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHF10", "PHF14", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIK3R4", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPT1", "POFUT2", "POGZ", "POLDIP3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPIL3", "PPM1G", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKAG1", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSPC1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RABGAP1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBMX", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "ROCK1", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "S100A13", "SAE1", "SAP18", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCPEP1", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMN1*", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX2", "SOD2", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SPTLC2", "SREK1", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG2", "STAT1", "STAT3", "STOML2", "STRBP", "STT3A", "STX12", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUPT16H", "SUPT6H", "SURF6", "SUZ12", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TCERG1", "TCP1", "TDRKH", "TECR", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TM9SF2", "TM9SF3", "TMED10", "TMED7", "TMED9", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRIP4", "TRMT6", "TROVE2", "TSFM", "TSG101", "TSTA3", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UCK2", "UGGT1", "UNC119B", "UPF1", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP3", "UTP6", "UXS1", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR82", "WIZ", "XAB2", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM4", "ZNF281", "ZW10", "ZYX"], "leading_proteins": ["ADK", "ANP32B", "ANP32E", "AP1M1", "AP2S1", "AP3S1", "APOL2", "ARHGDIA", "ARIH1", "ARPC1A", "ARPC1B", "ARPC4", "ATP6V0A1", "ATP6V0A2", "ATP6V1B2", "ATP6V1H", "ATPAF1", "BAG6", "BAIAP2", "BUB1", "CAB39", "CACYBP", "CALM3", "CAP1", "CCNB1", "CDC42", "CDK12", "CDK4", "CDK5", "CIRBP", "CLASP1", "CLIC4", "CLTB", "CLUH", "CNN2", "COPA", "COPB2", "COPG1", "COPG2", "COPS3", "COPS8", "COPZ1", "COTL1", "CRTAP", "CSE1L", "CTBP1", "CTTN", "CUL5", "CYB5D2", "DCAF8", "DCTN1", "DHCR24", "DHCR7", "DHFR", "DICER1", "DNM2", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "EEA1", "EEF1B2", "EEF1D", "EHD1", "EHD4", "EHMT1", "EIF2S1", "EIF3B", "EIF3E", "EIF3J", "EIF3L", "EIF4B", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "EPS15", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EZR", "FNTA", "FUS", "GAPVD1", "GATAD2B", "GTF3C5", "HDGF", "HDGFL2", "HMGA1", "HMGB1", "HMGB3", "HMGN2", "IPO4", "IPO5", "IPO7", "ITCH", "KDM1B", "KIF11", "KIF18A", "KIF5B", "KPNA6", "LAMC1", "LSM6", "M6PR", "MAGED2", "MAPRE1", "MAPRE2", "MFN1", "MFSD5", "MIA3", "MORF4L2", "MPC2", "MPV17L2", "MSH2", "MSN", "NAMPT", "NAP1L4", "NISCH", "NSFL1C", "NSMCE3", "NT5DC1", "NUCB1", "NUCB2", "NUDC", "NUP37", "OLA1", "PAK2", "PDCD5", "PDLIM1", "PDLIM5", "PFDN5", "PHF14", "PI4KB", "PKN2", "PLEC", "PLIN3", "POGZ", "PPP6R3", "PPT2", "PRKACA", "PRMT1", "PRMT3", "PRMT5", "PSMD1", "PSMD2", "PSMD3", "PSMD8", "PSMF1", "PTPA", "PXMP2", "RAD23B", "RALA", "RANBP1", "RANBP3", "RBM3", "RCN2", "RDX", "REPS1", "RHOA", "RPS6KA1", "RPS6KA3", "RRM1", "RRM2", "S100A11", "S100A13", "SAP18", "SEC23A", "SEC24A", "SEPT11", "SEPT8", "SEPT9", "SERPINB6", "SET", "SF3A2", "SLC19A1", "SLC25A17", "SLC25A20", "SLC25A26", "SLC25A32", "SLC33A1", "SLC35F1", "SMARCAD1", "SMN1*", "SMYD3", "SPAG9", "SRPK2", "SRSF12", "SRSF6", "STAG2", "TAF15", "TAGLN2", "TBCD", "TBCE", "TMED9", "TMOD3", "TNPO1", "TSFM", "TSG101", "TUBB4B", "TUBB6", "TXLNA", "TXLNG", "TXNDC9", "UBE4A", "UNC119B", "VBP1", "VPS33A", "VPS4A", "WIZ", "ZC3H15", "ZNF281", "ZW10", "ZYX"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6e0847ffc649d08286e63465c7dfff7898d31ecd --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6aab8afbdb58bf75c830601aea749f0e74c5ce75 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8cb28379d7099e85395d3a2e917e1a3b4e9384c97649f54f259051d440119023 +size 219252 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..d9752f64bcde7c3d52fb03a0871b9304fad457d3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio", "1": "Tdark"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..cf5f2f0af7349bab66c8cc16adaaf9a554c26908 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a98d55d49c79eabf7b0ea1e9d13d65c821ff44eec40d9353ab4a7356e2e2454a +size 127181 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..48e1f28d5c7aee9fb43304f64ea298e53995c384 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:487d206b2f93f6d7d915476e2978545dbcdb16f06e3a168ce37b64d20e90fc33 +size 137137 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..85134182fe04ecc6b5553bf9003d1b2eb3b80dd7 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:491819ffb69f8f2306a30dbe68c74e3248dfb05816260916605ef472f52bc0b0 +size 60890 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..63cce4ef8ec62da401ce233fab711dbcf44235f2 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tbio 361 1896 2.6809270422851528 0.0073418520780514 467.6796116504854 2434.25 -0.5416405556668178 0.3215141878443288 119.73666199244032 234.70955636597876 4.704421961664106 0.4116627836259234 1.0 0.7937522987645925 0.715638979831357 0.2182477992081831 0.0001411354963229 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..831832d0725fc6e60e4c0cc7147e01dff1e499df --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 611.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d172c5ae386e1484c8dfd8f08aa101b197584a20 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..95d84568d35bb10f5bdd9963bc894388ca0cc012 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tbio 0.1808402738662169 2.6809270422851528 0.0073418520780514 0.029045571640379 0.0293674083122059 1896 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361 +Tdark 0.298765983414245 0.8661463750169979 0.3864098963435811 0.8582531600236438 0.5152131951247748 218 Q8WUJ1,Q9NVZ3,P61009,Q7Z4Q2,Q5T1Q4,P62312,Q9Y320,O60830,Q96EY4,Q8IZ69,Q8TBQ9,Q99590,Q6N075,Q9NR77,Q9BV44,Q5TC12,Q8NBF2,Q9BTY7,Q96EL3,Q6ZRI6,Q9Y3C1,Q9NW82,Q9UFG5,Q5T8P6,O00193,Q9Y5Q8,P49750,Q96CT7,Q9BVK6,Q6NXE6,Q8NFH4,Q969T7 32 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..93d1d76babd06981af67c6afcc2756ee99edfa69 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", 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"CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM208B", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NEK9", "NELFA", "NELFB", "NENF", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2B", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", 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conjugation pathway 45 92 2.8335241921203997 0.0046037823120952 39.72330097087379 126.52184466019418 -0.3906356571472509 0.5381051627839192 16.022015823401837 22.367886318219735 1.2547606520431642 0.3543570936569808 1.0 0.8050224281557943 0.9850965708946018 0.6341837034120485 0.2921875393892256 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f25f8157fb3aee4239cc6f312af466f42d7276f2 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 155, + "title": "Average number of proteins per term", + "value": 26.219354838709677 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..24ab99b8b89cb60f3a67a94fa49332cb96864c7a --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a9e023c2e39404c4b1d75772fa1cc1f2147ad079 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,44 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Ubl conjugation pathway 0.4480635352698169 2.8335241921203993 0.0046037823120952 0.5109223042850027 0.1427172516749524 92 Q9NT62,Q9UBT2,Q15018,Q7Z6E9,Q16763,Q9UPN9,Q15386,Q9NXR7,P19474,Q9UJX4,P68036,Q9ULT8,Q9H4L4,O94874,Q8TEY7,Q86WB0,P30260,Q9Y2K7,Q9Y3C8,Q86VP6,Q9Y4X5,Q96MG7,Q9HB71,P61081,P54727,Q5VTR2,Q8TBC4,A0AVT1,Q14258,Q9H8M7,P63208,P45974,Q9Y314,O75592,Q93034,Q5T4S7,Q7Z6Z7,Q96FW1,Q86UV5,Q96T88,Q9UJX2,Q13263,Q5TAQ9,Q96J02,Q14139 45 +Angiogenesis 0.6707902638142968 1.9339026760059697 0.053125095057332 0.999788478742155 0.434934204143756 10 O75340,Q9BXJ9,Q9H2J4,P35613 4 +Glyoxylate bypass 0.9975470155355683 1.9195633405162775 0.0549130783563431 0.9998421946343332 0.434934204143756 2 P48735 1 +Exocytosis 0.6815197373343755 1.6194336068127355 0.1053540008762246 0.9999999679417556 0.4796406124264212 7 Q5JRA6,Q8TAG9 2 +Stress response 0.4634246535580282 1.586579745783654 0.1126078577132176 0.9999999909235772 0.4796406124264212 27 P55145,Q14011,P98179,P04792 4 +Protein biosynthesis 0.3540376221172795 1.5552030592347796 0.1198977159532808 0.9999999974728097 0.4796406124264212 84 Q7Z2Z2,P60228,Q7L2H7,P78344,O75822,Q04637,P23381,Q13155,P29692,Q6PKG0,P56537,P23588,Q9Y262,O43324,P55010,P06730,Q7Z478,P55884,P05198,P60842,P24534,P43897,P26639,O43776,Q9UI10,Q9NR50 26 +Purine salvage 0.7167217142511582 1.5085256273695662 0.131420052751364 0.999999999672268 0.4796406124264212 5 Q13126,P55263 2 +Pyrimidine biosynthesis 0.7151614976013444 1.5019911036962246 0.1330994063922055 0.999999999757204 0.4796406124264212 5 P11172,Q9NRF8,P17812 3 +Transport 0.2603140464754282 1.4657623176283034 0.1427130502229874 0.9999999999568916 0.4796406124264212 362 Q9NT62,Q9NVZ3,P02656,O43633,Q92734,O43772,O60684,O60664,Q5T1Q4,Q14847,Q8TEX9,Q92973,Q14203,P20645,O60749,Q15904,Q8N6T3,Q9BUN8,O60830,Q5JRA6,Q9BQE5,A6NIH7,Q8TAG9,Q9H814,Q9BW83,O00400,O95563,Q6N075,Q99720,P35606,P41440,P20290,O75352,P22570,Q9BXS5,P83436,Q6DKK2,Q70HW3,Q13409,Q9H2D1,P20339,Q9BVK6,O00471,Q8NFH4,O43592,Q96AX1,Q15436,Q99584 48 +Oogenesis 0.8814390842191338 1.4514668090654044 0.146649918003686 0.9999999999788788 0.4796406124264212 2 Q9Y5A9 1 +Inflammatory response 0.5848685299881928 1.4251721170411884 0.1541074542002212 0.9999999999945818 0.4796406124264212 9 P04083 1 +Tricarboxylic acid cycle 0.4924566006789841 1.4212207129779908 0.1552526049315732 0.999999999995608 0.4796406124264212 18 P48735 1 +Differentiation 0.349957003144235 1.380300417600591 0.1674941664525668 0.9999999999995428 0.4992614576951512 65 Q96PU8,P16949,O14786,Q08J23,Q13363,Q15645,Q96EP5,Q13155,Q6DKJ4,Q9BW83,Q96EK5,P54652,Q96TC7,P46379,Q96A49,Q9H3U1,P78362,P60953,Q99829,Q9Y5A9,Q13685,Q7Z6Z7,Q6P6C2,Q9Y6E2,P17931,O60869,Q9BXJ9,O75312 28 +Phagocytosis 0.8078495502861842 1.1538923682364894 0.2485442984292545 1.0 0.5926825577928376 2 P20339 1 +Lipid transport 0.4727581582240447 1.1373983394394105 0.2553718011683954 1.0 0.599736805774262 15 Q99720,P02656 2 +Glutathione biosynthesis 0.7973008680098167 1.0958013933967332 0.2731656985876505 1.0 0.6169783830106377 3 Q9UJ14 1 +Cilium biogenesis/degradation 0.4674569027978804 1.068630069011151 0.2852363938375934 1.0 0.6253235818907703 14 O95684,A6NIH7,Q9Y5Y2 3 +DNA condensation 0.593123209169055 0.9885678906009489 0.3228746026708726 1.0 0.6482532120230039 5 Q9NTJ3,O95347,Q15021,Q9BPX3 4 +Immunity 0.3193289135721667 0.983847719698514 0.3251903922760655 1.0 0.6482532120230039 63 P14174,Q9Y5A9,Q9UQ84,O60828,P04083,Q13325,O15347,Q96J02 8 +Protein transport 0.2995371671115264 0.943074624400169 0.3456427341968628 1.0 0.6744894858634279 174 Q9NT62,Q9NVZ3,O43633,O60684,Q8TEX9,Q92973,O60749,Q8N6T3,Q9BUN8,O60830,Q5JRA6,A6NIH7,Q8TAG9,Q9H814,Q9BW83,Q9Y5X3,P49321,P35606,Q9H4M9,Q99816,P20290,Q9BXS5,P83436,P20339,Q9BVK6,O00471,Q8NFH4,Q96AX1,Q15436,Q99584 30 +Myogenesis 0.5994271685760931 0.7924634254613228 0.4280905096735925 1.0 0.7806356352871394 4 P51114,Q9H3U1,Q14331 3 +Spermatogenesis 0.3795931042167635 0.7671359680053389 0.4430006787833536 1.0 0.7984314559467419 19 Q15645,Q96EP5,Q9Y5A9,Q6P6C2,Q9BW83,Q08J23,P54652 7 +Host-virus interaction 0.2909969324041665 0.7347686216398883 0.4624804201966435 1.0 0.8145961946645425 216 O43633,P04792,Q96T37,Q92973,Q7L2H7,Q9Y6G9,Q9BUN8,P61586,Q04637,P25789,Q9NXV2,Q01105,Q13363,P49721,P28072,P28074,P28070,Q9UPY3,Q99436,Q9UBW8,Q92688,P35613,Q9BXS5,Q9UBF8,P20618,Q13409,Q9Y5A9,Q15942,Q9ULX6,Q04323,P40763,Q96J02,O60684 33 +Unfolded protein response 0.5259169865385599 0.7135930039446219 0.4754788848692788 1.0 0.8196545985288628 5 Q9BUN8 1 +ER-Golgi transport 0.3038173745094871 0.561980206403401 0.5741295050905189 1.0 0.8599023597788736 39 Q8N6T3,Q15436,Q92734,Q5JRA6 4 +Innate immunity 0.2809753353066899 0.4585639165933284 0.6465473534747492 1.0 0.9279151832276492 53 P14174,Q9Y5A9,P04083,Q13325,O15347,Q96J02 6 +DNA repair 0.2594963210947924 0.414571377411479 0.6784557050069786 1.0 0.9592171156107372 87 Q9H1E3,Q9H4L7,Q9UQ84,P51530,Q9BXW9,Q9NXR7,Q9NRR5,Q92547,P43246,P15927,Q15014 11 +GMP biosynthesis 0.6034341782502122 0.4052314599815683 0.6853073820664597 1.0 0.9592171156107372 2 P49915 1 +Serine biosynthesis 0.5854456255110467 0.3526956340589757 0.724316632809999 1.0 0.9683797749656724 2 O43175 1 +Cell division 0.2368875664812505 0.3416934663289384 0.7325815896033918 1.0 0.970514071696801 112 Q16763,Q14203,Q9NXR7,Q9Y6G9,Q9UJX4,Q08J23,P61586,Q86WB0,O43768,Q15555,Q9NQW6,P52732,Q99816,Q9NTJ3,Q9P258,Q9Y5K6,Q6DKK2,Q9Y5A9,Q96CT7,Q15691,Q8NFH4,Q9UJX2,Q00535,P11802 24 +DNA replication 0.2696894227789528 0.3330855791356524 0.7390696846409477 1.0 0.9708118738927703 41 P49321,P31350,P27694,P33991,Q7Z6E9,P23921,P49642,P51530,P39748,Q07864,Q9BRT9,Q13112,Q08945,P33993,P25205,P09884,P15927 17 +Growth regulation 0.339618531823427 0.2983860663634504 0.7654085224130562 1.0 0.971216702923741 9 Q15014 1 +Steroid biosynthesis 0.2959867512520845 0.2525581309240491 0.8006096879143891 1.0 0.971216702923741 17 Q15392 1 +Cell shape 0.3915911312710459 0.2488438692590625 0.8034815554489874 1.0 0.971216702923741 5 P35579,P15311 2 +Wnt signaling pathway 0.2950526343144829 0.2336258964445555 0.8152754215749118 1.0 0.971216702923741 16 Q6PD62 1 +Purine biosynthesis 0.3198031980319882 0.2323701031112152 0.8162505677093421 1.0 0.971216702923741 9 P22102,P49915,P30520,P12268,P22234,Q06203,O15067,P30566 8 +DNA damage 0.2366318020854018 0.2254172464406793 0.8216546961542934 1.0 0.971216702923741 99 Q9H1E3,Q9H4L7,P27695,Q9UQ84,P51530,P57081,Q9BXW9,Q9NXR7,Q9NRR5,P54727,Q92547,P43246,Q9NVI1,P15927,Q15014 15 +Biological rhythms 0.2579199838998948 0.2091806745388442 0.8343071981924146 1.0 0.971216702923741 38 Q9Y2K7,Q13148,P43490,O14744,O75592 5 +Isoprene biosynthesis 0.4779231398201261 0.1192098250632747 0.9051091228835904 1.0 1.0 2 P14324 1 +Cell cycle 0.2331768095856434 0.0467095998980559 0.9627446790864848 1.0 1.0 170 Q16763,Q14203,Q9NXR7,P19474,Q9Y6G9,Q9UJX4,Q08J23,Q12824,P61586,Q86WB0,O43768,Q15555,Q9NUQ3,Q13526,Q9NQW6,Q8TBC4,P49321,P52732,Q99816,Q9NTJ3,Q9Y266,Q9P258,Q9Y5K6,Q6DKK2,Q92733,Q9Y5A9,Q15418,Q96CT7,Q9UN37,Q96T88,Q15691,Q9BXW9,Q8NFH4,Q9UJX2,Q00535,P11802,Q9NVI1 37 +Prostaglandin metabolism 0.3237430809210416 0.0150789977151112 0.9879691564536508 1.0 1.0 3 Q14914 1 +Fucose metabolism 0.2955846279640315 0.0126802855222823 0.9898828670776204 1.0 1.0 2 Q9Y2G5 1 +Translation regulation 0.2147341645948965 0.0036657054075022 0.9970751968011936 1.0 1.0 41 Q96PU8,Q9Y6M1,P78344,P23396,Q04637,Q92600,A5YKK6,Q6PKG0,Q92616,Q9BY44,P06730,P82979,O00425,Q13217,P05198,Q92615,Q9BX40,Q9H2U1,P04406,P07814,P61221 21 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9195b2b22349d4719ef641f3246ee823bdb2fca7 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Biological rhythms", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Complement pathway", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF3", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADK", "ADNP", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCY", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8L", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGEF2", "ARID1A", "ARIH1", "ARL2", "ARL3", "ARL6IP4", "ARMT1", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "AUP1", "AURKA", "BABAM2", "BAG6", "BANF1", "BAX", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BICD2", "BIRC6", "BLM", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "CACUL1", "CACYBP", "CAD", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC86", "CCNB1", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLSPN", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNOT1", "CNOT9", "COG7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DCAF1", "DCAF13", "DCAF8", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DPF2", "DPYSL2", "DSC3", "DSG2", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERO1A", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAM162A", "FAM208A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FRG1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCC2", "GCFC2", "GCLC", "GCN1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGT7", "GHITM", "GINS4", "GMPS", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOT1", "GOT2", "GPHN", "GPI", "GRB2", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSS", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GTPBP4", "GYS1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HIBADH", "HIBCH", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KAT7", "KCTD5", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIF11", "KIF18A", "KIF20A", "KIF20B", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LPCAT1", "LRPPRC", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MANF", "MAP1S", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED23", "MFSD5", "MGA", "MGEA5", "MGST2", "MIA3", "MIF", "MINDY3", "MKI67", "MLEC", "MMS19", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MRE11", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH6", "MSN", "MTA1", "MTAP", "MTCH2", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYH10", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEK9", "NELFA", "NEO1", "NEU1", "NFS1", "NHP2", "NIP7", "NISCH", "NKRF", "NLE1", "NME1", "NME2", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC2", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "NXN", "OGDH", "OGT", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PANK4", "PARK7", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCNA", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDS5A", "PDS5B", "PECR", "PELP1", "PES1", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4KB", "PICALM", "PIGS", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLIN3", "PLK1", "PLRG1", "PNN", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "PPAT", "PPCDC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAG1", "PRKDC", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RARS", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM14", "RBM15", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCOR1", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RMDN3", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "ROCK1", "RPA1", "RPA2", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC22B", "SEC23A", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG8", "SMN1*", "SMNDC1", "SMU1", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SON", "SORT1", "SPATA5", "SPECC1L", "SPEN", "SPOUT1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG2", "STAT1", "STAT3", "STAU1", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBCB", "TCAF1", "TCERG1", "TDRKH", "TECR", "TERF2", "TERF2IP", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THRAP3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TK1", "TLN1", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM214", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOLLIP", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC4", "TTLL12", "TUBB2B", "TUFM", "TWISTNB", "TXLNA", "TXLNG", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UFC1", "UFD1", "UFL1", "UFSP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "WARS", "WBP11", "WDR12", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR5", "WDR6", "WDR61", "WDR75", "WTAP", "XAB2", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YTHDF2", "YWHAB", "YWHAE", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "ABCE1", "ABRAXAS2", "ADK", "ADSL", "ADSS", "AIMP2", "AKAP8L", "ALKBH5", "ANAPC5", "ANLN", "ANP32B", "ANXA1", "AP1M1", "APEX1", "APOC3", "APOL2", "ARFGAP1", "ARIH1", "ATG3", "ATP6AP1", "BABAM2", "BAG6", "BSG", "BTF3", "BZW2", "CACYBP", "CAND1", "CCDC124", "CD2AP", "CDC23", "CDC27", "CDC42", "CDK4", "CDK5", "CHAF1B", "CHMP2A", "CIRBP", "CNOT1", "CNOT9", "COG7", "COPB2", "COPS7A", "CPNE1", "CTBP1", "CTPS1", "CTPS2", "CTR9", "CUL5", "DAZAP1", "DCAF8", "DCTN1", "DERL1", "DHCR24", "DHX29", "DHX36", "DICER1", "DNA2", "DNAJC3", "DYNC1I2", "DYNC1LI1", "EDF1", "EEF1B2", "EEF1D", "EEF1E1", "EFL1", "EHD1", "EIF2A", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "ENSA", "EPRS", "EXO1", "EXOC5", "EXOC6", "EZR", "FANCD2", "FANCI", "FDPS", "FDXR", "FEN1", "FGFR1OP", "FRG1", "FXR1", "GAPDH", "GART", "GCN1", "GGT7", "GINS4", "GMPS", "HECTD1", "HMGB3", "HSPA2", "HSPB1", "HUWE1", "IDH2", "IFIT5", "IFT27", "IGF2BP2", "IGF2BP3", "IMPDH2", "IPO4", "ITCH", "KCTD5", "KDM2A", "KIF11", "KIFBP", "KPNA6", "LARP1", "LARP4B", "LASP1", "LGALS3", "LSM14B", "M6PR", "MANF", "MAPRE1", "MAPRE2", "MCM3", "MCM4", "MCM7", "MFSD5", "MIA3", "MIF", "MINDY3", "MORF4L2", "MPC2", "MPDU1", "MSH2", "MTAP", "MYCBP2", "MYH9", "NAA15", "NAMPT", "NARS", "NASP", "NCAPD2", "NCAPG", "NECAP2", "NOSIP", "NRP1", "NSMCE3", "NSUN2", "NUBP2", "NUCKS1", "NUDC", "NUP37", "NXN", "OTUB1", "PAICS", "PDCD6", "PDCL3", "PFAS", "PHAX", "PHGDH", "PI4KB", "PIN1", "PLIN3", "POFUT2", "POLA1", "POLE", "PPAT", "PQBP1", "PRCC", "PRIM1", "PRMT5", "PSMA4", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PTGR1", "QKI", "RAB5A", "RAD23B", "RBBP6", "RBM15", "RBM3", "RCC2", "RHOA", "RMDN3", "RNF20", "RPA1", "RPA2", "RPS3", "RPS6KA1", "RRM1", "RRM2", "S100A13", "SARNP", "SEC23A", "SENP3", "SET", "SIGMAR1", "SKP1", "SLC19A1", "SLC25A20", "SLC25A26", "SLC25A32", "SLC33A1", "SLC35F1", "SMARCAD1", "SMARCB1", "SMC2", "SMC4", "SNX2", "SNX5", "SRPK2", "SSRP1", "STAT3", "STMN1", "SYAP1", "TARDBP", "TARS", "TFG", "TIMM17B", "TMED9", "TNPO1", "TOPBP1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSFM", "TSG101", "TTC19", "TXLNG", "UBA2", "UBA3", "UBA6", 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file mode 100644 index 0000000000000000000000000000000000000000..186f2cfb1da774c571aa3cbdaf34d126fd1cecec --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +FDA approved drug targets 14 96 2.1412107516102994 0.0322570463980522 24.04854368932039 119.4247572815534 0.6623112070438231 0.5745671660823485 8.39802177443113 10.190737689187452 0.8635117376862006 0.3683507047501689 1.0 0.0017095662884662 0.0019277415570695 0.0148535815906084 0.040936806936637 +Ectodermal dysplasia 1 6 2.0796815487311187 0.0375547515811001 2.9514563106796117 6.507281553398058 -0.4235540324570562 0.5441437566939271 1.7102128453051049 1.137381334192038 0.8300523137977316 0.306451667339201 1.0 0.0738393547118652 0.0162721684360546 0.1091182558828044 0.3404572117496941 +Palmoplantar keratoderma 1 6 1.961948106700094 0.0497685262060119 2.1771844660194173 6.66747572815534 -0.1081341805887323 0.4396415732659258 1.523334307555052 1.0537084013340434 1.0756885176480049 0.2789379081020651 1.0 0.0516999782711156 0.0079643961350226 0.0574475369379932 0.0479408885811084 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8e612ecd8c63dd367f9e0431e9b29643f4638fa0 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 105, + "title": "Average number of proteins per term", + "value": 18.485714285714284 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..db3f1959c60691e057ef1437cbf3460118c18ea8 --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ee91556169878c57a1b71abf800f4f0daf5f1d5b --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,25 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +FDA approved drug targets 0.3872243165508531 2.1412107516102994 0.0322570463980522 0.968025639466222 0.211686866987218 96 Q99720,P02656,P48735,O75874,Q99707,P49721,P20645,P04083,P49354,P28074,P38435,P20618,Q14353,Q16637 14 +Ectodermal dysplasia 0.8121633842298439 2.0796815487311187 0.0375547515811001 0.9820326744122884 0.2319558185891477 6 P61586 1 +Palmoplantar keratoderma 0.7838989388214268 1.961948106700094 0.0497685262060119 0.9953001048610852 0.2741509054214293 6 Q06136 1 +Congenital disorder of glycosylation 0.6455314777211768 1.907796454482969 0.0564175292076354 0.9977515369829206 0.2820876460381771 11 Q15904,Q8N511,O75352,P36871 4 +Proto-oncogene 0.4552520044573611 1.730276107848188 0.0835809561309079 0.9998953158128472 0.3646160289669612 35 Q92734,P35637,Q16204,Q06136,Q01844,P61586,Q92804,Q01105 8 +Charcot-Marie-Tooth disease 0.550443604281567 1.6391514775039382 0.1011817163958079 0.9999863368980532 0.3646160289669612 16 P04792 1 +Cancer-related genes 0.2972128302034366 1.6261456942418724 0.1039186654282489 0.999990080717503 0.3646160289669612 325 P02656,P48735,Q92734,P04792,O75874,Q96T37,Q14847,Q14203,P60228,P00338,P04179,P04083,P00374,P43490,Q96AE4,P16949,P55327,Q06136,P98175,Q12824,Q9H7B4,P61586,Q04637,Q9BQE5,P43246,Q01105,Q06124,P14174,P62993,P20810,Q9UDY2,Q13526,P54727,P54652,Q9UPY3,P41440,Q99816,P09960,Q9H6Z4,Q16204,Q02952,P25685,Q9NYV4,Q93034,P11413,P17096,Q13451,P35637,P27695,Q13867,O95684,P80303,P11047,Q9BXW9,P40763,Q01844,P17931,Q9ULK4,P46777,P11802,Q92804,P15927 62 +Amyotrophic lateral sclerosis 0.5609268540789107 1.5077198348652696 0.1316262468324203 0.9999996333917172 0.4080836926487283 12 Q99720,Q14203,Q9NRR5,P35637 4 +Neuropathy 0.4049104928381783 1.3423147407818612 0.1794939658675596 0.99999999904811 0.4959701688445726 36 Q92734,P04792,Q14203,O95831,P22570 5 +Primary microcephaly 0.6038018360458834 1.269833022745661 0.2041441150364258 0.9999999999613084 0.5054137142514489 7 P35606,Q86XL3,Q15021,Q8NFH4 4 +Microphthalmia 0.6312135347418217 1.1484701888216946 0.2507745128160064 0.9999999999999316 0.5602409328868228 5 P41227 1 +Fanconi anemia 0.7721707839345385 1.0033896911704718 0.3156728760458955 1.0 0.6463672662750284 3 Q9BXW9 1 +Hereditary nonpolyposis colorectal cancer 0.762469337694198 0.9733168030301992 0.3303958737801471 1.0 0.6463672662750284 2 P43246 1 +Hereditary spastic paraplegia 0.4875312271647807 0.9469526087979364 0.3436629284225674 1.0 0.6463672662750284 9 O00400,Q92734,P07384 3 +Obesity 0.7561059062162139 0.9448351793434072 0.3447430286389772 1.0 0.6463672662750284 3 Q9BW83 1 +Progressive external ophthalmoplegia 0.7412101390024572 0.8903015338194971 0.373303997767531 1.0 0.6562796674869424 2 P51530 1 +Osteogenesis imperfecta 0.4835196106144162 0.732283240903967 0.4639957062632818 1.0 0.7296157762151758 7 Q96AY3 1 +Systemic lupus erythematosus 0.6500568035588574 0.5773330886705671 0.5637144653398252 1.0 0.7892002514757552 3 P12956 1 +Holoprosencephaly 0.6210139002453057 0.4596507365093174 0.6457669351867579 1.0 0.8169340746338504 2 Q8N3U4 1 +Parkinsonism 0.4239638606296168 0.4363991379075659 0.6625471643380445 1.0 0.8281839554225556 6 Q14203,Q6Y7W6 2 +Cushing syndrome 0.5958228094177935 0.4114601765663246 0.6807351365128038 1.0 0.8409081098099341 3 P10644 1 +Limb-girdle muscular dystrophy 0.4145122101237214 0.3148433788603722 0.7528805738150024 1.0 0.8766403432064365 5 O14979,Q15149 2 +Diabetes mellitus 0.341064891856039 0.2075727757034031 0.8355625631962642 1.0 0.913896553495914 7 P40763,O60343 2 +Epidermolysis bullosa 0.3288343558282142 0.0163151355527426 0.9869829827238136 1.0 1.0 3 Q03001,Q15149 2 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..18542c30117a6a4e173d2e23211e53b5d0febdae --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "Maple syrup urine disease", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peters anomaly", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKR1B1", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOC3", "APOL2", "APP", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL2", "ARL3", "ARPC1B", "ASAH1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATXN10", "AURKA", "B4GAT1", "BANF1", "BAX", "BAZ1B", "BCAP31", "BCAT2", "BCLAF1", "BICD2", "BIRC6", "BLM", "BLMH", "BMS1", "BPTF", "BRCA1", "BRD4", "BRI3BP", "BUB1B", "C19orf70", "C1QBP", "CAD", "CALM3", "CALR", "CANX", "CAPN1", "CARM1", "CARS", "CAST", "CBFB", "CCAR1", "CCAR2", "CCDC47", "CCDC6", "CCNB1", "CCT5", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDKAL1", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHEK2", "CISD2", "CKB", "CKMT1A*", "CLCC1", "CLCN7", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNOT1", "COA7", "COG7", "COLGALT1", "COMT", "COPA", "COPB2", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBN1", "DBT", "DCAF8", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSC3", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHMT1", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERGIC1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FABP5", "FAF1", "FAM120A", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FDPS", 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pval_50 pval_100 pval_250 pval_500 +Initiation factor 16 33 2.938453033572668 0.0032985463142478 12.29126213592233 35.407766990291265 -0.0821190079233033 0.5969551913028055 6.190159851695042 1.941808251479095 1.0044409846809916 0.334601111447651 1.0 0.1218413011779254 0.0434222212102392 0.0150344454800679 5.290660756454005e-08 +Rotamase 6 18 2.0518174834771137 0.040187403526354 5.225728155339806 21.04368932038835 0.2903016415772153 0.5738010430803833 3.1033990453756255 2.0966996675039535 0.9519067598216118 0.3277712839255824 1.0 0.0820121143628169 0.0200341360556442 3.11011006293786e-05 3.605392845365783e-05 +Dioxygenase 5 14 2.0354732807275333 0.0418032743826568 4.485436893203883 16.929611650485437 0.3291673001296444 0.5856007381165738 2.3948329397108954 3.0857324105273336 0.8401407542250483 0.3144845391083291 1.0 0.1674341055486001 0.3758826063580091 0.0110668373474651 0.0661517851593171 diff --git a/protein_atlas_molecular_function/metrics.json 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0000000000000000000000000000000000000000..3304eb1ac9d50997df9508a5275a4f02bee4f724 --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,33 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Initiation factor 0.6237200897856623 2.938453033572668 0.0032985463142478 0.2669752849767197 0.0442947647913284 33 P60228,Q7Z478,Q7L2H7,P55884,Q9UI10,P78344,P56537,Q9NR50,P23588,O75822,Q9Y262,P05198,P60842,Q04637,P55010,P06730 16 +Cytokine 0.9452967519642466 2.149853683538559 0.0315667902470218 0.9509601252608554 0.1817644952002753 4 P43490 1 +Rotamase 0.5954009435041874 2.0518174834771137 0.040187403526354 0.9788395034288654 0.2068161995773549 18 Q9H2H8,Q13526,Q15257,Q96AY3,Q9Y3C6,Q02790 6 +Dioxygenase 0.6417084242603901 2.0354732807275333 0.0418032743826568 0.9819390683434476 0.2068161995773549 14 Q9Y2K7,Q6P6C2,O60568,Q9C0B1,O15460 5 +Methyltransferase 0.4777697751692279 1.913768149535627 0.0556497868705909 0.9954026266811576 0.2490990459921691 35 Q9H9B1,Q8IZ69,O14744,Q99707,O60678,Q8N6R0,Q08J23,Q99873,Q7L2J0,Q9H7B4,Q14353,Q9BV44,O15047 13 +Threonine protease 0.9734151329243346 1.7502383530738608 0.0800771933763431 0.999608591474236 0.2895098529760097 3 P28072,P28074 2 +GTPase activation 0.5452617358448505 1.608906799056785 0.107636722581812 0.999977565373288 0.3613518543817974 16 P43487,O60343,P52565,Q8N6T3,Q15042,Q8TC07 6 +Oxidoreductase 0.3197952435134183 1.426726208448576 0.1536588281933175 0.9999998453770222 0.4376948439446015 139 Q13363,Q13630,P48735,Q9Y2K7,O75874,Q6P6C2,Q15392,Q8N4Q0,Q8NB78,P04179,O95831,P22570,O60568,Q9C0B1,Q06136,Q9UHG3,P30837,O15460 18 +Calmodulin-binding 0.4446638895423273 1.3774541818583468 0.1683718711975879 0.999999970259928 0.4540119218037958 25 P35579,P29966,Q15417,Q99439,Q05682,Q13813,Q13576,Q01844,O60869,Q02952,P35580,Q5T4S7 12 +Guanine-nucleotide releasing factor 0.5684908132556771 1.344747404806062 0.1787068202844728 0.9999999908202188 0.4540119218037958 9 P80303,O75592,Q02818 3 +Growth factor 0.8369665675076412 1.2429832762234037 0.2138739962341973 0.9999999998499406 0.5097872393971462 3 P55145 1 +Aminopeptidase 0.5312780936525184 1.2347307163523618 0.2169307401689983 0.999999999895956 0.5097872393971462 10 P55786,Q9UIQ6 2 +Nucleotidyltransferase 0.4370888301686825 1.1345724647579674 0.2565544956159407 0.9999999999992104 0.5741933949499625 19 O95602,Q9NWX6,P49642,Q07864,Q9H9Y6,P09884,P30876 7 +tRNA-binding 0.4543432914446917 0.9950582746271074 0.3197079226588384 0.9999999999999998 0.6500341293577989 14 P26639,Q9HAV4,Q7Z7L1,O75648,Q08J23,O43592,Q13325,P54577 8 +Chaperone 0.3082054496728956 0.9842002464046626 0.3250170646788994 1.0 0.6500341293577989 85 Q9UHV9,P04792,Q14019,Q99733,Q99471,P61758,Q8WXX5,Q01105,P54652,O15212,Q02790,O95456,P20290,Q92688,Q9H3U1,P25685,Q9H2J4,O75937,Q13451,Q15813 20 +Multifunctional enzyme 0.3692979679086803 0.8814805405383467 0.3780577819239012 1.0 0.685000297822684 27 Q13630,O60568,P34913 3 +Elongation factor 0.4438519699346257 0.8562340115786649 0.3918683532137927 1.0 0.685000297822684 11 P24534,P29692,P43897 3 +Thiol protease 0.391666428214323 0.8430052838909426 0.399225488658242 1.0 0.685000297822684 19 Q8TEY7,Q9H8M7,Q13867,Q96FW1,P45974,Q86UV5,P07384,P17655,Q9H4L4 9 +Repressor 0.2893515819868816 0.8401968102022352 0.4007980465983789 1.0 0.685000297822684 97 Q8WXF1,Q9UPN9,P67809,P78344,Q15637,Q9H3P2,Q14011,O00267,Q92600,Q13363,Q9Y2K7,O14979,Q12872,P16989,P61978,Q13247,P51858,Q8NB78,Q92766,Q99829,P49750,P27695,Q13148,Q96T88,Q8WXI9,Q01844,Q13263,O14744 28 +Endonuclease 0.3959913021396981 0.7735140849847537 0.4392181962669337 1.0 0.737259115162353 17 Q15631,P27695,Q9UQ84,P51530,Q9UPY3 5 +Actin-binding 0.2958648795901021 0.7492559279885578 0.4537029656473683 1.0 0.7482119082605723 64 Q9NYL9,P29966,Q14847,Q14019,O15143,O15144,P35579,Q8WX93,Q99439,Q01518,P35241,Q9NQW6,P59998,P35609,Q9Y281,Q05682,Q14331,P35580,P18206,Q92747 20 +Tumor antigen 0.696238757154543 0.7198565626414362 0.4716133148619692 1.0 0.7643388206383639 2 Q96MG7 1 +DNA-directed DNA polymerase 0.518099972149291 0.4973620211915938 0.6189337825759862 1.0 0.9383834768087532 4 P09884 1 +Chromatin regulator 0.262989048175455 0.449809924621426 0.6528475010343424 1.0 0.9403694707130036 71 P61964,Q9H4L7,Q8NB78,Q9NXR7,Q9H7B4,O15047,Q15014 7 +Muscle protein 0.4959870837955263 0.4246362641167461 0.6711018527749109 1.0 0.9403694707130036 4 Q05682,P60660 2 +Actin capping 0.4140940927229114 0.4011663512537789 0.6882976526573872 1.0 0.9403694707130036 6 Q01082,P35241,Q13813 3 +Protease 0.2570550639998737 0.3996100706461242 0.6894437378463967 1.0 0.9403694707130036 68 Q99436,P61009,Q9H8M7,P09960,P81605,P28074,P28072,Q9UIQ6,P55786,Q9HB40 10 +Glycosyltransferase 0.2860285143510829 0.3128069098014713 0.754427365392597 1.0 0.9939076540966928 27 P07741,P11172,P43490,O60568,P13807,Q13126 6 +DNA-binding 0.2588372626019058 0.2797005662679578 0.7797072438430497 1.0 1.0 192 Q9UQ84,P51530,Q96AE4,P19474,Q92547,P43246,Q01105,Q15631,Q9H4L7,Q9Y2K7,P29692,O14979,Q12789,Q02818,O14646,Q9Y2U8,P16989,P53999,P51858,P05204,O95831,P46063,Q92766,Q9Y5Q8,P17096,P27695,P35637,P80303,P40763,O15347,O60869,Q92804,P15927 33 +Metalloprotease 0.2376305690412161 0.0713636811472502 0.943108314129664 1.0 1.0 23 P55786,Q9UIQ6 2 +Myosin 0.2703809913969656 0.0605378262133947 0.9517272901187144 1.0 1.0 7 P35579,O43795,P60660,Q9UM54,P35580,O00159 6 +Chloride channel 0.3386503067484614 0.0190641138428865 0.9847899592289292 1.0 1.0 3 O00299,Q9Y696 2 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b8cc9028e18361842ea79fb5d384dbfd1ef9403d --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD6", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APLP2", "APP", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BANF1", "BAZ1B", "BCAT2", "BCLAF1", "BDH2", "BIRC6", "BLM", "BLMH", "BLVRA", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BSG", "BTF3", "BUB1", "BUB1B", "BZW1", "BZW2", "CAD", "CALD1", "CALR", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDK1", "CDK12", "CDK4", "CDK5", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHORDC1", "CHRAC1", "CHTOP", "CIRBP", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSTB", "CSTF2", "CSTF2T", "CTBP1", "CTBP2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CUL5", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCD", "DCPS", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIAPH1", "DICER1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "EMD", "EMG1", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERCC2", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "F11R", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGT7", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP4", "IMPDH2", "IQGAP1", "IQGAP2", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LACTB", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRPPRC", "LRWD1", "LSG1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAPK1", "MAPK14", "MAPK3", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MGA", "MGEA5", "MGST2", "MGST3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH6", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "NDUFAF2", "NDUFAF4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NEK9", "NELFA", "NEU1", "NFS1", "NHP2", "NIFK", "NIP7", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUCB1", "NUCB2", "NUDT1", "NUDT21", "NUDT5", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PEBP1", "PECR", "PELP1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHF5A", "PHF6", "PHF8", "PHGDH", "PI4KB", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "RFC1", "RHOA", "RHOT1", "RHOT2", "RIDA", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SOD2", "SON", "SORT1", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SRCAP", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAT1", "STAT3", "STAU1", "STMN1", "STRBP", "STT3A", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "TAF15", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TCERG1", "TCP1", "TDRKH", "TECR", "TERF2", "TERF2IP", "TFAM", "TFCP2", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM50", "TJP1", "TK1", "TKT", "TMCO1", "TMEM109", "TMOD3", "TMTC3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSN", "TSNAX", "TSTA3", "TTK", "TUFM", "TWF1", "TXNDC12", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UCK2", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF3B", "UROD", "USP10", "USP14", "USP15", "USP33", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP3", "UTRN", "UXS1", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS4A", "VPS4B", "VRK1", "VRK2", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDF2", "ZADH2", "ZC3H14", "ZC3HAV1", "ZCCHC3", "ZFR", "ZMPSTE24", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687"], "leading_proteins": ["ACTN2", "AIFM1", "AKAP12", "ALDH1B1", "ALKBH5", "ANLN", "ANP32B", "APEX1", "APRT", "ARFGAP1", "ARHGDIA", "ARPC1A", "ARPC1B", "ARPC2", "ARPC4", "BABAM2", "BLMH", "BTF3", "CALD1", "CAP1", "CAPN1", "CAPN2", "CFL2", "CHD1", "CIRBP", "CLIC1", "CLIC4", "CNN2", "CNN3", "CNOT9", "COTL1", "CPNE1", "CTBP1", "DCD", "DHCR24", "DHX29", "DICER1", "DNA2", "DNAJB1", "DNAJC8", "DNAJC9", "EDF1", "EEF1B2", "EEF1D", "EHMT1", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "EPHX2", "EWSR1", "EXO1", "FDXR", "FKBP10", "FKBP4", "FKBP5", "FRG1", "FTO", "FUBP1", "FUS", "GAMT", "GATAD2B", "GTF3C1", "GTF3C5", "GYS1", "HDGF", "HMGA1", "HMGB3", "HMGN2", "HNRNPDL", "HNRNPK", "HSPA2", "HSPB1", "IDH1", "IDH2", "IFIT5", "IQGAP2", "KDM1B", "KDM2A", "KDSR", "LASP1", "LEMD3", "LNPEP", "LTA4H", "MANF", "MARCKS", "MEPCE", "METTL13", "MINDY3", "MORF4L2", "MSH2", "MTAP", "MTR", "MYCBP2", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAMPT", "NAP1L4", "NELFA", "NPEPPS", "NSMCE3", "NSUN2", "NUCB1", "NUCB2", "OTUB1", "P4HA2", "PALLD", "PCYOX1", "PDCL3", "PFDN2", "PFDN5", "PFDN6", "PIN1", "PLOD3", "POLA1", "POLE", "POLR1A", "POLR1B", "POLR2B", "PPIL1", "PPIL3", "PRIM1", "PRMT1", "PRMT3", "PRMT5", "PSMB5", "PSMB6", "PSMB7", "PSMG1", "PSPC1", "PTPA", "RAB3GAP1", "RANBP1", "RDX", "RECQL", "RPA2", "RREB1", "SCPEP1", "SENP3", "SET", "SETD1A", "SF1", "SFSWAP", "SLFN11", "SMARCAD1", "SMYD3", "SOD2", "SPCS3", "SPTAN1", "SPTBN1", "SRSF6", "STAT3", "SUB1", "SUPT5H", "TAF15", "TARDBP", "TARS", "TBC1D15", "TBC1D4", "TBCE", "THG1L", "THUMPD3", "TMOD3", "TOPBP1", "TRIM21", "TRIM28", "TRIM33", "TRMT2A", "TRMU", "TSFM", "TSN", "TSTA3", "UBR4", "UHRF1", "UMPS", "UNC45A", "USP33", "USP48", "USP5", "VBP1", "VCL", "WDR5", "XPO5", "XPOT", "YARS", "YBX1", "YBX3", "YLPM1", "ZADH2"]} \ No newline at end of file diff --git a/protein_atlas_protein_class/advanced/idx2term.json 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0000000000000000000000000000000000000000..f13790ec525160385049d7b60fde8e34bd03119b --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted intracellular proteins 734 2294 inf 0.0 1052.9126213592233 2930.233009708738 -5.248196350890207 0.108353777008802 367.4824441165934 294.4528727150831 7.24167812525605 0.3049463326237019 0.8975088269741103 0.8118380193875592 0.9082195794746156 0.3147457240611458 0.000129891685152 +Predicted secreted proteins 15 42 2.989898090235948 0.0027907053730129 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 1.0 0.0001111036826985 0.0041010444044074 0.0002593033065587 0.0440033056799577 +FDA approved drug targets 14 96 2.1412107516102994 0.0322570463980522 24.04854368932039 119.4247572815534 0.6623112070438231 0.5745671660823485 8.39802177443113 10.190737689187452 0.8635117376862006 0.3683507047501689 1.0 0.0017095662884662 0.0019277415570695 0.0148535815906084 0.040936806936637 +RAS pathway related proteins 9 15 2.047257496269601 0.0406328087827514 7.766990291262136 26.781553398058257 -0.2983378099034785 0.610349556628825 4.193624109843778 4.642129733294932 0.7602821796183953 0.2972845099899509 1.0 0.3034717003587399 0.6056006036801387 0.932923694534662 0.4994311465744407 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8eaa009dcc1609895b695a24a0a805439d3c239d --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2448, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 403.6 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0d91408eb2645dcac688d70960f24d1def4a54fc --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C331/C331_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..21a6a562197650e07b3f0ff1a08dc77f12f65e15 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted intracellular proteins 0.2488614725909128 inf 0.0 2e-17 2e-17 2294 Q9H773,Q8WUJ1,P48735,P34913,O43772,P04792,O75874,O75153,Q9UQ84,Q7L2H7,Q8N4Q0,O60888,P20645,P04083,Q15904,P43490,P19474,Q8WXF0,Q06136,Q9UHG3,P30837,Q9H7B4,P61586,Q96AY3,O60830,Q9NXV2,O15460,Q13363,Q8N511,Q5VZE5,P14174,A6NIH7,Q8TAG9,Q9H4L7,Q99439,Q8IZ69,P34896,Q15392,Q9BW83,Q9UDY2,Q99590,P28072,P28074,Q9NRR5,P28070,Q15257,Q6PD62,Q9UPY3,Q9NR77,Q14353,O00178,O15047,P55010,Q15014,Q5TC12,Q99720,Q9H1E3,Q99436,Q8NBF2,P61964,P16989,P53999,Q13247,Q6ZRI6,Q9UBW8,Q9NRF8,Q9UNW1,Q8NB78,P35613,P51665,O95831,P22570,Q9UFG5,Q9C0B1,P46063,Q02952,Q9BXS5,Q9UBF8,Q6Y7W6,P35237,Q86UY6,Q9HB40,P43897,Q9H2H8,Q96B36,Q9NWX6,Q9H2J4,Q70HW3,P17096,P49750,P35637,Q6P6C2,Q96CT7,P80303,Q15942,O00471,Q04323,Q15691,Q6NXE6,Q8NFH4,Q9UJX2,Q01844,Q9UMR5,Q9ULK4,P55263,P55786,P28161,Q14157,Q15436,Q92804,Q969T7,Q96J02,Q99584,Q9NT62,Q9NVZ3,O43633,P61009,Q92734,Q9H7B2,Q9UQB8,Q7Z4Q2,Q15428,Q14847,P80723,P41227,Q14019,O76094,P04179,P62312,Q8N6T3,Q9H6V9,Q9NXR7,O75822,P84098,P98179,Q14011,Q7L2J0,Q9Y320,Q92547,Q9BQE5,Q15075,Q16637,Q01105,P36871,O75340,Q13630,Q8WX93,Q96EY4,Q9BZX2,Q9NZB2,Q9Y2K7,Q9Y3C8,Q9Y376,P40616,Q99707,P49721,Q9H814,Q9Y4X5,Q9UM22,P57081,Q13526,P23588,O95563,O60568,P56937,Q13325,Q8IWA4,Q8TBC4,Q8TC07,Q96TC7,Q9BV44,P61927,Q9Y3C6,Q02790,P35606,O43399,Q9BTY7,Q9Y5Y2,Q9Y281,Q9UNZ2,Q9H8M7,Q96EL3,P51858,P20290,P09960,O75352,Q92688,Q9Y3C1,Q9NW82,Q9NTK5,Q9H223,Q86TI2,Q16204,Q15042,P25685,O14745,Q5T8P6,O00193,P83436,O60678,O75592,P20618,Q13126,Q6DKK2,Q99627,Q9Y5Q8,Q9NUQ9,Q99829,Q13409,Q9Y5A9,Q13451,Q9H2D1,P20339,O00273,O95684,O43242,P11047,Q03252,Q9ULX6,Q9NZW5,Q9NR50,Q9BXW9,P49354,P40763,P0DP25,O60869,O43592,O14744,Q96AX1,Q9UHB9,Q9BXJ9,Q9BVC5,O15347,Q969Z3,P15927,O60684,O60664,Q9Y312,Q8TEX9,Q9BZZ5,Q96T37,Q92973,Q9UJ14,Q16763,Q14203,P51530,P48556,O60828,O60749,O43660,Q15637,Q96AE4,Q9Y6G9,Q9UJX4,Q9H3P2,Q99873,Q99733,Q99471,Q3YEC7,Q04637,P61758,P43246,P25789,P23381,P17812,Q06124,Q9BUK6,Q8TEY7,Q86WB0,Q15645,Q15631,Q15555,O60343,Q01518,P62993,P29692,P25787,P20810,O95182,O14979,P56537,Q9Y5X3,Q9NQW6,Q9BRT9,Q8NHQ9,Q12872,Q12789,Q00169,P61081,P54727,P54652,A0AVT1,O14646,O43324,O15212,O95372,P05387,P49321,P52732,Q8N543,Q9NPH0,Q9H9B1,Q9H910,Q9H4M9,Q99816,Q8NBZ7,Q7Z478,Q5TFE4,P55884,P52565,P07384,P05204,O43396,O14737,Q9H6Z4,Q96A49,Q9BUF5,Q9H3U1,Q9H6T3,Q9Y490,Q9NQ88,Q9NYV4,Q9P258,Q92766,Q9Y5K6,Q93034,Q5TBB1,Q7Z4V5,P21281,Q69YN4,O43776,O75937,P11413,O43818,P27695,P49903,Q13148,Q13867,O15355,Q15813,Q9UI10,Q9NTZ6,Q9NRN7,Q9NR28,Q8WXI9,Q8N684,Q8N0X7,P17931,Q13310,Q00535,P46777,P17655,P11802,P07197,O95104,O75312,Q9NVI1,Q8N6R0,Q92530,Q92747,Q96SU4,Q15061,Q9NYL9,Q9UBT2,Q9UHV9,Q9UNS2,Q7L014,Q7Z6E9,P60228,Q5BKZ1,P48506,Q15386,P00338,P00374,P16949,O75648,P55327,O15143,P98175,Q08J23,Q13200,Q12824,Q9Y2L1,Q9UQ13,Q9ULT8,Q9NQZ5,Q9H4L4,Q92600,Q8WXX5,Q6FI81,Q66PJ3,Q14914,P42566,P09497,O43719,O43768,O95394,P07741,O60271,P26196,P30626,P31949,P35241,Q9NUQ3,Q86X55,Q8IWJ2,Q8NCA5,Q96EK5,Q9BVQ7,Q9HB71,Q9Y2V2,Q9UBV2,Q9Y262,Q9Y296,Q9Y2T2,Q5VTR2,Q9Y4C8,Q7Z417,O00151,Q14258,P35609,O60256,O95456,O95602,P15311,Q14257,P18085,P43487,P51116,P61978,P63208,Q05682,Q9BTW9,Q1KMD3,Q7L2E3,Q8WWY3,Q92900,P26885,Q9NQ50,Q9NTJ3,Q9UBB4,Q9Y266,Q08945,Q14331,P05198,P50570,P24534,P13807,P09884,A1L0T0,O95983,O75251,O43847,O43747,P26639,Q9H993,Q92733,Q96G03,Q96S59,Q9H857,Q9Y520,Q9NRY5,Q9NVH1,Q9NVX2,Q9UN37,Q86UV5,Q8NC51,Q96T88,Q7Z7L1,Q12899,P04406,Q5VYK3,P17858,P60900,Q07812,P18669,Q13263,Q15008,Q15418,Q5TAQ9,Q5TDH0,P83881,Q8IYB8,Q06323,Q07666,Q14139,Q14789,Q7LGA3,Q7Z2Z2,Q7Z3T8,Q9C0C2,Q8WWM7,Q8WXF1,Q92945,Q96PU8,Q99729,Q9UPN9,Q9Y2I1,Q9Y2W1,P67809,P78344,Q99570,P63173,P11172,O14786,O15144,O43808,O95373,O95470,O95861,P06737,P08670,O00267,P11233,P33176,P25325,P50995,P35579,P51452,P31948,P30260,Q96EP5,Q04917,Q13155,Q14247,Q6DKJ4,Q6PKG0,Q92785,Q96CN7,Q9BUP0,Q96HC4,Q99460,Q9BTT0,Q9BY42,Q9NQZ2,Q9UJW0,Q9UL46,P55060,P59998,P61201,P54619,P30876,P53680,O00154,O00231,O43237,P06730,P13674,P14635,P30085,P14314,P31689,P48739,P52701,P38159,P49642,P46379,P45974,P39748,Q07864,Q9Y314,Q9UBV8,Q96SY0,Q8WU90,Q86XL3,Q6ZWJ1,P33993,P78362,P60953,P60842,P35580,P00568,O15372,O14776,P61923,Q5T4S7,Q6IAA8,Q6IA86,Q69YN2,Q8IV48,Q5H9R7,Q16630,Q13685,Q7Z6Z7,P78316,Q8N3U4,Q96D71,Q96FW1,Q96NB2,Q9BTT6,Q9H501,Q9H9Y6,Q9Y6E2,Q13177,P30046,P61513,P18206,O00422,O00763,O15067,O43252,O60502,P08243,P55039,P22626,O00410,P30153,P39019,P50747,P51991,P54105,P29966,Q92499,Q15018,Q15427,Q16555,Q6UN15,Q86Y56,Q8N766,Q9P287,Q92905,Q96KB5,Q99549,Q9P2R3,Q9UHI6,Q9UKA9,Q9Y3A5,Q01081,Q13596,Q15149,P68036,O95793,P63151,O43264,O43683,O60763,O75534,O94880,O94903,O95163,O94874,P09429,P27694,P30520,P31150,P33991,P52758,P10644,Q5JTV8,Q8WUM4,Q86VP6,Q5VTL8,Q5VT66,Q15021,Q4G0J3,Q3B726,Q15650,Q96MG7,Q8WWC4,Q9Y5K5,Q96QK1,Q99961,Q9GZZ1,Q9NPF4,Q9UN86,Q9UNM6,Q9Y2G5,Q9Y3F4,Q9Y696,Q14974,Q14C86,Q15020,Q13610,P37802,O95486,P06493,P12956,P17612,P18124,P23921,P26038,P33240,P35998,P36915,P12814,P42766,Q10567,P49591,O75935,Q13112,Q13098,Q13217,P68371,P63104,P62191,P54577,Q9BTE6,Q6P1J9,Q7L1Q6,Q7Z460,Q8NI77,Q92598,Q92615,Q96C86,Q9NVA2,Q9NP92,Q15417,Q9P2E9,Q9UBF2,Q9UI12,Q9UNF1,Q9Y282,Q9Y678,Q9UHD8,Q13547,Q15185,P16383,Q13243,O14530,O14818,O75717,O95757,P06400,P09132,P10155,P00491,P25205,P55209,P30566,P61026,P57678,P61221,P53621,P49643 734 +Predicted secreted proteins 0.5717894465330761 2.989898090235948 0.0027907053730129 0.0543588661604651 0.0079734439228941 42 Q8WUJ1,P02656,P14174,P55145,Q9UMX5,P80303,O60888,Q9UM22,P04083,P43490,P81605,O60568,Q02818,Q9HB40,Q99584 15 +FDA approved drug targets 0.3872243165508531 2.1412107516102994 0.0322570463980522 0.4809605646471264 0.0645140927961045 96 Q99720,P02656,P48735,O75874,Q99707,P49721,P20645,P04083,P49354,P28074,P38435,P20618,Q14353,Q16637 14 +RAS pathway related proteins 0.6330397094052794 2.047257496269601 0.0406328087827514 0.5637883657521587 0.0738778341504571 15 P20339,P62993,Q13177,P0DP25,P60953,Q9UQ13,P61586,P11233,Q06124 9 +Cancer-related genes 0.2972128302034366 1.6261456942418724 0.1039186654282489 0.8885837285318471 0.1598748698896137 325 P02656,P48735,Q92734,P04792,O75874,Q96T37,Q14847,Q14203,P60228,P00338,P04179,P04083,P00374,P43490,Q96AE4,P16949,P55327,Q06136,P98175,Q12824,Q9H7B4,P61586,Q04637,Q9BQE5,P43246,Q01105,Q06124,P14174,P62993,P20810,Q9UDY2,Q13526,P54727,P54652,Q9UPY3,P41440,Q99816,P09960,Q9H6Z4,Q16204,Q02952,P25685,Q9NYV4,Q93034,P11413,P17096,Q13451,P35637,P27695,Q13867,O95684,P80303,P11047,Q9BXW9,P40763,Q01844,P17931,Q9ULK4,P46777,P11802,Q92804,P15927 62 +Citric acid cycle related proteins 0.4153204002067634 1.1141630589986975 0.2652092400652308 0.997894895171207 0.3536123200869744 23 P48735 1 +Transporters 0.2750161264185968 0.6074833300930437 0.5435302021481396 0.9999998457443934 0.6039224468312663 274 Q9NT62,Q8TEX9,Q9NPA0,O43772,Q5T1Q4,P80723,O76094,P20645,P04083,Q15904,P81605,Q9Y320,Q9BUN8,Q5JRA6,O75340,Q8N511,Q8TAG9,Q9H814,O00400,O95563,Q6N075,Q9NRR5,Q8IWA4,Q9NR77,Q99720,P41440,P35613,O14745,Q9BXS5,Q70HW3,Q9H2D1,O00471,Q8NFH4,O43592,Q9UHB9,O60684 36 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..82018fa275a2db2e52a5afd6a1e7fb76347e44fd --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOC3", "APOL2", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAX", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C15orf39", "C19orf25", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "C5orf15", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP5", "CHMP6", "CHORDC1", "CHRAC1", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN3", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSPN", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT9", "CNP", "CNPY2", "COA7", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF2T", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CTU2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNASE2", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERI1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC5", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM208B", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGT7", "GHDC", "GHITM", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT1", "GOT2", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS4", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HECTD3", "HELLS", "HEXA", "HEXB", "HGH1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MFSD5", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPC2", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL49", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NEK9", "NELFA", "NENF", "NEO1", "NEU1", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPSNAP1", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP85", "NUP88", "NUP93", "NUP98", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIK3R4", "PIN1", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POFUT2", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPCDC", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB24", "RAB2A", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2B", "RNASET2", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC33A1", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC4A1AP", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPCS2", "SPCS3", "SPECC1L", "SPEN", "SPOUT1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF12", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF2", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM161A", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC37", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXS1", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WDR91", "WIZ", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AAR2", "AARSD1", "AASDHPPT", "ABCE1", "ABRAXAS2", "ACACB", "ACOT7", "ACP6", "ACTN1", "ACTN2", "ADK", "ADSL", "ADSS", "AIFM1", "AIMP2", "AK1", "AKAP12", "AKAP8L", "AKT1S1", "ALDH1B1", "ALKBH5", "ANAPC5", "ANKFY1", "ANKLE2", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "AP1B1", "AP1G1", "AP1M1", "AP2S1", "AP3M1", "APEX1", "API5", "APOC3", "APOL2", "APRT", "ARF4", "ARFGAP1", "ARHGDIA", "ARIH1", "ARL1", "ARL6IP4", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC4", "ASNS", "ATG3", "ATP6AP1", "ATP6V1B2", "ATP6V1H", "ATPAF1", "ATXN10", "ATXN2L", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BAX", "BCCIP", "BLMH", "BPNT1", "BSG", "BTF3", "BUB1", "BZW1", "BZW2", "C11orf58", "C15orf39", "C19orf25", "C2orf49", "CAB39", "CACYBP", "CALD1", "CALM3", "CAND1", "CAP1", "CAPN1", "CAPN2", "CARHSP1", "CARM1", "CAST", "CCDC124", "CCDC6", "CCNB1", "CD2AP", "CDC23", "CDC27", "CDC42", "CDC73", "CDK1", "CDK12", "CDK4", "CDK5", "CFL2", "CHAF1B", "CHD1", "CHMP2A", "CIAPIN1", "CIRBP", "CLASP1", "CLIC4", "CLNS1A", "CLTB", "CLUH", "CMPK1", "CNN2", "CNN3", "CNOT9", "COG7", "COPA", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS5", "COPS7A", "COPS8", "COPZ1", "COTL1", "CPNE1", "CPSF6", "CPSF7", "CSDE1", "CSE1L", "CSTF2", "CTBP1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL5", "CUTA", "CWF19L1", "CYB5D2", "DAZAP1", "DCAF8", "DCD", "DCPS", "DCTN1", "DCTN3", "DCTN4", "DCTPP1", "DDI2", "DDT", "DDX1", "DDX20", "DDX46", "DDX55", "DDX6", "DERL1", "DFFA", "DHCR24", "DHFR", "DHX29", "DHX30", "DIABLO", "DICER1", "DIS3", "DNA2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC11", "DNAJC3", "DNAJC8", "DNAJC9", "DNM2", "DPF2", "DPP9", "DPYSL2", "DRG2", "DUSP3", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "EDF1", "EEA1", "EEF1B2", "EEF1D", "EEF1E1", "EFHD1", "EFL1", "EHD1", "EHD4", "EHMT1", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3H", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "ELP1", "ELP2", "EMC1", "EMC7", "ENSA", "EPDR1", "EPHX2", "EPS15", "ERGIC3", "ERI1", "ESF1", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EZR", "FAM114A2", "FAM120A", "FAM49B", "FAM98A", "FANCD2", "FANCI", "FDXR", "FEN1", "FGFR1OP", "FIP1L1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FNTA", "FRG1", "FTO", "FUBP1", "FUS", "FXR2", "G3BP2", "G6PD", "GAMT", "GAPDH", "GAPVD1", "GATAD2B", "GCC2", "GCFC2", "GCLC", "GDI1", "GEMIN4", "GGCX", "GGT7", "GIGYF2", "GINS4", "GNL1", "GOLGB1", "GPS1", "GRB2", "GSTM2", "GTF3C1", "GTF3C5", "GTPBP1", "GYS1", "HDAC1", "HDGF", "HDGFL2", "HEATR3", "HECTD1", "HGH1", "HLCS", "HMGA1", "HMGB1", "HMGB3", "HMGN2", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPDL", "HNRNPK", "HNRNPUL2", "HS2ST1", "HSD17B7", "HSPA2", "HSPA4L", "HSPB1", "HSPH1", "HTATSF1", "HUWE1", "IDH1", "IDH2", "IFIT5", "IFT27", "ILVBL", "INTS14", "IPO4", "IPO5", "IPO7", "ISOC1", "ITCH", "JPT2", "KCTD5", "KDM1B", "KDM2A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF18A", "KIF5B", "KIFBP", "KPNA6", "KPNB1", "LAMC1", "LAMTOR1", "LARP1", "LARP4B", "LARP7", "LASP1", "LDAH", "LDHA", "LGALS3", "LMNB2", "LRRC1", "LSM6", "LTA4H", "LYPLA2", "M6PR", "MAGED2", "MAIP1", "MANF", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MBD3", "MCM3", "MCM4", "MCM7", "MED23", "MEPCE", "METTL13", "MFN1", "MFSD5", "MGEA5", "MIA3", "MIF", "MINDY3", "MINPP1", "MORF4L2", "MPC2", "MPDU1", "MPHOSPH8", "MPP6", "MPST", "MRPL40", "MRPL53", "MRPS30", "MSH2", "MSH6", "MSN", "MSTO1", "MTAP", "MTR", "MYCBP2", "MYH10", "MYH9", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NAMPT", "NAP1L1", "NAP1L4", "NARS", "NASP", "NCAPD2", "NDUFA7", "NDUFS7", "NECAP2", "NEFM", "NELFA", "NENF", "NHLRC2", "NISCH", "NLE1", "NOP14", "NOP16", "NOSIP", "NPEPPS", "NRDC", "NRP1", "NSFL1C", "NSMCE3", "NSUN2", "NT5C3B", "NT5DC1", "NT5DC2", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUFIP2", "NUP37", "NXN", "OGFOD1", "OLA1", "OSBPL9", "OSGEP", "OTUB1", "P4HA1", "P4HA2", "PABPC4", "PAK2", "PALLD", "PAPSS1", "PBK", "PCYOX1", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDLIM1", "PDLIM5", "PEF1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PGAM1", "PGM1", "PGM2", "PGM3", "PHAX", "PHF14", "PI4KB", "PIK3R4", "PIN1", "PITPNA", "PITPNB", "PLEC", "PLIN3", "PLOD3", "PLPBP", "PLRG1", "PNP", "POFUT2", "POLA1", "POLE", "POLR1A", "POLR1B", "POLR2B", "PPIL1", "PPIL3", "PPM1G", "PPP2R1A", "PPP2R2A", "PPP6R3", "PPT2", "PQBP1", "PRCC", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRPF31", "PRPF38B", "PRPSAP2", "PRRC2C", "PSMA2", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMD1", "PSMD11", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSMF1", "PSMG1", "PSPC1", "PTBP2", "PTGES3", "PTGR1", "PTPA", "PTPN11", "PWP1", "PXMP2", "PYGL", "QKI", "RAB10", "RAB3GAP1", "RAB5A", "RABL6", "RAD23B", "RALA", "RANBP1", "RANBP3", "RANBP9", "RB1", "RBBP6", "RBM10", "RBM12", "RBM15", "RBM19", "RBM26", "RBM3", "RBMX", "RCC2", "RCN2", "RDX", "RECQL", "REPS1", "RHOA", "RIDA", "RMDN3", "RNASEH2B", "RNF20", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL19", "RPL35", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL5", "RPL7", "RPLP2", "RPS19", "RPS6KA1", "RRBP1", "RREB1", "RRM1", "RRP9", "RTFDC1", "S100A11", "S100A13", "SAP18", "SARS", "SART3", "SBDS", "SCAF11", "SCAF4", "SCPEP1", "SEC23A", "SEC24A", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT9", "SERBP1", "SERPINB6", "SET", "SETD1A", "SF1", "SF3A2", "SF3B4", "SFSWAP", "SFXN2", "SGPL1", "SH3GL1", "SHMT1", "SHOC2", "SIGMAR1", "SKP1", "SLC19A1", "SLC25A17", "SLC25A20", "SLC25A26", "SLC25A32", "SLC33A1", "SLC35F1", "SLC9A3R1", "SLFN11", "SMARCAD1", "SMARCB1", "SMC4", "SMN1*", "SMYD3", "SNX1", "SNX2", "SNX5", "SOD2", "SPAG9", "SPART", "SPATA5L1", "SPCS3", "SRI", "SRP19", "SRP68", "SRP72", "SRPK2", "SRSF12", "SRSF5", "SRSF6", "SSRP1", "STAG2", "STARD7", "STAT3", "STAU1", "STIP1", "STMN1", "STRAP", "STXBP4", "SUB1", "SUPT5H", "SUPV3L1", "SYAP1", "TAF15", "TAGLN2", 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200 +Cell Junctions 0.4377887687924828 1.6955716238406595 0.0899670354426438 0.9554461641298996 0.2828880406841199 38 P43490,P02656 2 +Plasma membrane 0.3457858553118145 1.6731589273050391 0.0942960135613732 0.9619331258400948 0.2828880406841199 209 Q9NT62,Q8WUJ1,O43633,Q9C0C2,P04792,Q9UQB8,Q14847,P80723,Q16763,Q15386,P67809,O60888,P04083,P06737,P61586,P11233,Q8WXX5,P35579,Q5VZE5,P31948,Q8WX93,P09497,Q14247,P20810,P35241,Q9UDY2,Q12872,Q13325,Q8TBC4,O00151,P15311,Q9Y281,P41440,Q9UNZ2,Q9H910,Q99816,Q9H4M9,P55011,Q05682,P26885,Q9H223,Q9UBB4,Q02952,O14745,Q9Y490,Q9Y5K6,Q96CT7,O00273,Q15942,P11047,P04406,Q8N0X7,P17931,Q00535,P55263,P83881,Q99584 57 +Centriolar satellite 0.5112210605292931 1.4704524949952462 0.1414392427470683 0.9934770488917232 0.359038077742558 17 P11413,Q5T1Q4,Q86UY6,Q15691,Q9Y490,O14745,Q9Y5K6 7 +Actin filaments 0.3740476673850868 1.2470999595781205 0.2123608477803837 0.99962085898385 0.4671938651168443 41 Q9NYL9,P62312,P17812,Q06124,P35579,Q8WX93,Q99439,Q99460,O75718,O00151,P35609,P37802,Q05682,P12814,P35580,P26639,Q15417,Q9UI12,Q9UI10,Q15942,Q9Y6E2 21 +Focal adhesion sites 0.4399777597895633 1.153281662440731 0.2487947943114512 0.9999205610616346 0.5131392632673681 19 Q15942,O60888 2 +Microtubules 0.2995257609847938 0.5738324649028862 0.5660811774848509 0.9999999999989174 0.8491217662272763 41 P54105,Q9Y624,Q14203,Q9Y2I1,Q9HC35,Q99570,O60830,O43768,Q13813,Q8WWK9,Q02818,P31689,Q9BUF5,P68371,P60953,P13807,Q8NI77,Q8IV48,Q13409,Q13685,P55209 21 +Intermediate filaments 0.2875020424141239 0.2942096825588997 0.7685976822967684 1.0 0.9047700058872846 24 O95602,P58107,Q96G03,P07197,Q9UFG5,Q15149,Q99471,O75718,P08670,Q96K76,Q86YN1 11 +Cytoplasmic bodies 0.3131606955211578 0.2651577347447715 0.7908879526082089 1.0 0.9047700058872846 12 P26196,Q92600,Q9Y5A9,Q92973 4 +Centrosome 0.2451204194982633 0.1635083780211486 0.8701181772154967 1.0 0.9047700058872846 49 O95684,Q92688,Q9Y6G9,P28074,Q3YEC7,Q8TBC4,P35237 7 +Lipid droplets 0.2924465829415176 0.1543259554396667 0.8773527329816093 1.0 0.9047700058872846 9 Q01105 1 +Nuclear speckles 0.2184013739409598 0.0817704789546714 0.9348292318179668 1.0 0.9348292318179668 104 Q9BZZ5,Q7L014,Q7Z6E9,P48556,O60828,O43660,P43490,P98175,Q9Y3C8,O15047,P05387,Q13247,Q9H3U1,Q5T8P6,Q9NYV4,Q92766,P49750,Q9ULX6,Q14157 19 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f49ebd0debb7229bc39071d6aecf9f0db13f40fc --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD6", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ADAR", "ADD1", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP1", "AKAP12", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANGEL1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOC3", "APP", "APRT", "AQR", "ARCN1", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARL1", "ARL2", "ARL3", "ARL6IP4", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD5", "ATG3", "ATIC", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "AURKA", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C15orf39", "C19orf25", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "C5orf15", "CAB39", "CACUL1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK4", "CDK5", "CDK5RAP3", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CERS1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", 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"DBN1", "DBT", "DCAF1", "DCAF13", "DCAF8", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOLPP1", "DPF2", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSC3", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFCAB14", "EFHD1", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELP1", "ELP2", "EMC8", "EMD", "EMG1", "EML4", "ENO1", "ENSA", "EPB41", "EPB41L2", "EPHX2", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERCC2", "ERCC6L", "ERGIC1", "ERH", "ERI1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC6", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FABP5", "FAF1", "FAF2", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM208A", "FAM208B", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FOXC1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGT7", "GHITM", "GIGYF2", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLS", "GLUD1", "GLYR1", "GMPS", "GNA13", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGB1", "GOLIM4", "GOT1", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRPEL1", "GRSF1", "GRWD1", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HECTD1", "HELLS", "HEXA", "HGH1", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS14", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ISOC1", "ISY1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC1", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIF11", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LACTB", "LAMC1", "LAMP2", "LAMTOR1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSG1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "MACF1", "MAGED2", "MAIP1", "MAK16", "MAN2B1", "MANF", "MAP1S", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAM", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED1", "MED23", "MEPCE", "METAP2", "METTL13", "MFN1", "MGA", "MGEA5", "MGST2", "MGST3", "MIA3", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPHOSPH10", "MPHOSPH6", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL53", "MRPL58", "MRPL9", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH6", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP2", "NEFM", "NELFA", "NEO1", "NEU1", "NFS1", "NHLRC2", "NIFK", "NIP7", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT21", "NUDT5", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP50", "NUP54", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPSS1", "PARK7", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCK2", "PCNA", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PES1", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHF10", "PHF14", "PHF3", "PHF5A", "PHF6", "PHF8", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIK3R4", "PIN1", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPCDC", "PPIB", "PPID", "PPIE", "PPIF", "PPIL1", "PPIL3", "PPIL4", "PPM1G", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP4C", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PUM3", "PUS1", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB14", "RAB1A", "RAB24", "RAB3B", "RAB3GAP1", "RAB5A", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL6", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDH14", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETSAT", "RFC1", "RFC2", "RFC4", "RFC5", "RHOA", "RHOT2", "RIF1", "RINT1", "RMDN1", "RMDN3", "RNASEH2B", "RNF114", "RNF20", "RNF40", "RNMT", "RNPEP", "RPA1", "RPA2", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT8", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A44", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F1", "SLC35F2", "SLC3A2", "SLC4A1AP", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCD2", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPCS2", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG2", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TAB1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TARDBP", "TARS", "TARS2", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCERG1", "TCOF1", "TDRKH", "TECR", "TELO2", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOP1", "THRAP3", "THUMPD3", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM44", "TIMM50", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMEM109", "TMEM161A", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM97", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRIM21", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC37", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWISTNB", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP15", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VKORC1L1", "VPS26A", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK2", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR33", "WDR36", "WDR4", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR77", "WDR82", "WIZ", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM4", "ZMYND8", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AAR2", "AARSD1", "ABCE1", "ABRAXAS2", "ACOT7", "ACTN1", "ACTN2", "ADK", "ADSL", "ADSS", "AIMP2", "AK1", "AKAP12", "AKAP8L", "AKT1S1", "ALDH1B1", "ALKBH5", "ANAPC5", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "AP1B1", "AP1G1", "APEX1", "API5", "APOC3", "APRT", "ARFGAP1", "ARHGDIA", "ARIH1", "ARL6IP4", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ASNS", "ATG3", "ATP6V1H", "ATXN10", "ATXN2L", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BCCIP", "BLMH", "BTF3", "BUB1", "BZW2", "C11orf58", "C15orf39", "C19orf25", "C2orf49", "CAB39", "CACYBP", "CALD1", "CAND1", "CAP1", "CAPN1", "CAPN2", "CARM1", "CAST", "CCDC124", "CCDC6", "CCNB1", "CD2AP", "CDC42", "CDC73", "CDK1", "CDK12", "CDK4", "CDK5", "CFL2", "CHD1", "CHMP2A", "CIAPIN1", "CIRBP", "CKAP2", "CLNS1A", "CLTB", "CLUH", "CNN2", "CNN3", "CNOT9", "COPG1", "COPS3", "COPS7A", "COPS8", "COTL1", "CPNE1", "CPSF7", "CRTAP", "CSDE1", "CSE1L", "CTBP1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL5", "CUTA", "CYB5D2", "DAZAP1", "DCAF8", "DCPS", "DCTN1", "DCTN3", "DCTPP1", "DDI2", "DDX1", "DDX20", "DDX46", "DDX55", "DDX6", "DFFA", "DHX29", "DHX30", "DICER1", "DIS3", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC8", "DNAJC9", "DNM2", "DOLPP1", "DPP9", "DPYSL2", "DRG2", "DUSP3", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "EDF1", "EEF1B2", "EEF1D", "EEF1E1", "EFL1", "EHD1", "EHD4", "EHMT1", "EIF2B3", "EIF2B4", "EIF2S1", "EIF3B", "EIF3E", "EIF3H", "EIF3J", "EIF3L", "EIF3M", "EIF4A1", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF5", "EIF6", "ELP1", "ELP2", "EML4", "ENSA", "EPHX2", "EPPK1", "EPS15", "ERI1", "EWSR1", "EXO1", "EXOC6", "EZR", "F11R", "FAM120A", "FAM49B", "FANCD2", "FANCI", "FGFR1OP", "FKBP2", "FKBP4", "FKBP5", "FNTA", "FTO", "FUBP1", "FUS", "FXR2", "G3BP2", "G6PD", "GAPDH", "GAPVD1", "GATAD2B", "GCC2", "GCLC", "GDI1", "GEMIN4", "GGT7", "GIGYF2", "GINS4", "GPS1", "GRB2", "GSTM2", "GTF3C1", "GTF3C5", "GTPBP1", "GYS1", "HDGF", "HDGFL2", "HEATR3", "HECTD1", "HGH1", "HLCS", "HMGA1", "HMGB3", "HMGN2", "HNRNPDL", "HSPA2", "HSPA4L", "HSPB1", "HSPH1", "HTATSF1", "HUWE1", "IDH1", "IFIT5", "IPO4", "IPO5", "IPO7", "ITCH", "JPT2", "KDM1B", "KDM2A", "KIF11", "KIF18A", "KIF5B", "KPNA6", "KPNB1", "LAMC1", "LARP1", "LARP4B", "LARP7", "LASP1", "LDHA", "LGALS3", "LRRC1", "LSM6", "LTA4H", "LYPLA2", "MAGED2", "MAPRE1", "MAPRE2", "MARCKS", "MED23", "MEPCE", "METTL13", "MGEA5", "MIF", "MINDY3", "MORF4L2", "MPHOSPH8", "MPST", "MSH2", "MSTO1", "MTAP", "MTR", "MYCBP2", "MYH10", "MYH9", "NAA10", "NAA15", "NAA35", "NAA40", "NAMPT", "NAP1L1", "NAP1L4", "NARS", "NASP", "NCAPD2", "NEFM", "NELFA", "NHLRC2", "NISCH", "NPEPPS", "NSFL1C", "NSUN2", "NT5DC1", "NUBP2", "NUCB1", "NUCKS1", "NUDC", "NUFIP2", "NUP37", "NXN", "OGFOD1", "OLA1", "OTUB1", "PABPC4", "PALLD", "PBK", "PDCD5", "PDCD6", "PDCL3", "PDLIM1", "PEF1", "PFDN2", "PFDN5", "PFDN6", "PGM1", "PGM2", "PGM3", "PHAX", "PHF14", "PIK3R4", "PIN1", "PITPNA", "PITPNB", "PLEC", "PLPBP", "PLRG1", "PNP", "POLA1", "POLR1A", "POLR1B", "PPIL3", "PPM1G", "PPP2R1A", "PPP2R2A", "PPP6R3", "PQBP1", "PRKACA", "PRKAG1", "PRKAR1A", "PRMT1", "PRMT5", "PRPSAP2", "PRRC2C", "PSMA4", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMD1", "PSMD13", "PSMD3", "PSMD7", "PSMD8", "PSME1", "PSMF1", "PSMG1", "PTGES3", "PTPA", "PTPN11", "PYGL", "RAB3GAP1", "RAB5A", "RABL6", "RAD23B", "RALA", "RANBP1", "RANBP3", "RANBP9", "RBBP6", "RBM10", "RBM12", "RBM15", "RBM26", "RBM3", "RDX", "RECQL", "REPS1", "RHOA", "RNASEH2B", "RNF20", "RPA2", "RPAP3", "RPF2", "RPL19", "RPL35", "RPL36A", "RPL37A", "RPL38", "RPL5", "RPL7", "RPLP2", "RPS6KA1", "RREB1", "RRM1", "RRM2", "RRP9", "S100A11", "S100A13", "SAP18", "SARS", "SBDS", "SCAF11", "SCAF4", "SEC23A", "SENP3", "SEPHS1", "SEPT11", "SERBP1", "SERPINB6", "SET", "SETD1A", "SF1", "SF3A2", "SFSWAP", "SH3GL1", "SHMT1", "SHOC2", "SKP1", "SLC12A2", "SLC19A1", "SLC25A20", "SLC25A32", "SLC33A1", "SLC35F1", "SLC9A3R1", "SLFN11", "SMARCAD1", "SMARCB1", "SMC4", "SMN1*", "SMYD3", "SNX5", "SPAG9", "SPART", "SPATA5L1", "SPTAN1", "SRI", "SRP19", "SRP68", "SRPK2", "SRSF5", "SRSF6", "SSRP1", "STAT3", "STAU1", "STIP1", "STMN1", "STRAP", "STXBP4", "SUB1", "SYAP1", "TAF15", "TAGLN2", "TARDBP", "TARS", "TBC1D15", "TBC1D4", "TFG", "THUMPD3", "TIGAR", "TIMM17B", "TJP2", "TLN1", "TMA16", "TMOD3", "TMX2", "TNKS1BP1", "TNPO1", "TOPBP1", "TPD52", "TPD52L2", "TRAPPC4", "TRIM21", "TRIM25", "TRIM26", "TRIP13", "TRMT2A", "TROVE2", "TSFM", "TSG101", "TSN", "TSTA3", "TUBB4B", "TUBB6", "TXLNG", "TXNDC9", "TXNL1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2L3", "UBE2M", "UBE2S", "UBE3C", "UBQLN4", "UBR4", "UBXN1", "UCHL5", "UCK2", "UFC1", "UMPS", "UNC45A", "UPF1", "USP33", "USP47", "USP48", "USP5", "VBP1", "VIM", "VIRMA", "VPS33A", "WARS", "WDR4", "WDR5", "WDR70", "XPOT", "YARS", "YBX1", "YBX3", "YLPM1", "YTHDF2", "ZADH2", "ZC3H15", "ZC3HC1", "ZFYVE16", "ZNF326", "ZW10", "ZYX"]} \ No newline at end of file